Pethidine is also relatively contraindicated for use when a patient is suffering from liver, or kidney disease, has a history of seizures or epilepsy, has an enlarged prostate or urinary retention problems, or suffers from hypothyroidism, asthma, or Addison's disease.
Pethidine might be contraindicated when a patient has liver or kidney disease, has had seizures or epilepsy,  has an enlarged prostate, or has urinary retention problems. It might also be harmful if the patient has hypothyroidism, asthma, or Addison's disease.