who were the early settlers in the city where the route starts?
Paleo-Indian people
Detroit
Paleo-Indian people inhabited areas near Detroit as early as 11,000 years ago
from where does the u.s. route 16 in michigan begins? Detroit does it have a business loop? It was a business loop through downtown Farmington along Grand River Avenue
wiki:1571367
Detroit [SEP] Early settlement
Paleo-Indian people inhabited areas near Detroit as early as 11,000 years ago including the culture referred to as the Mound-builders. In the 17th century, the region was inhabited by Huron, Odawa, Potawatomi and Iroquois peoples. The first Europeans did not penetrate into the region and reach the straits of Detroit until French missionaries and traders worked their way around the League of the Iroquois, with whom they were at war, and other Iroquoian tribes in the 1630s. The Huron and Neutral peoples held the north side of Lake Erie until the 1650s, when the Iroquois pushed both and the Erie people away from the lake and its beaver-rich feeder streams in the Beaver Wars of 1649–1655.