what is its biological significance?
A biological role for Z-DNA in the regulation of type I interferon responses
Z-DNA
A biological role for Z-DNA in the regulation of type I interferon responses has been confirmed in studies of three well-characterized rare Mendelian Diseases: Dyschromatosis Symmetrica Hereditaria (OMIM: 127400), Aicardi-Goutières syndrome (OMIM: 615010) and Bilateral Striatal Necrosis/Dystonia. Families with haploid ADAR transcriptome enabled mapping of Zα variants directly to disease, showing that genetic information is encoded in DNA by both shape and sequence. 
the structure found in the cell that contains strands of dna is called a(n) nuclei what is its full form? Deoxyribonucleic acid what is base pairing? In a DNA double helix, each type of nucleobase on one strand bonds with just one type of nucleobase on the other strand, his is called complementary base pairing. are there any alternative structures? Yes, DNA exists in many possible conformations that include A-DNA, B-DNA, and Z-DNA forms how is it replicated? The two strands are separated and then each strand's complementary DNA sequence is recreated by an enzyme called DNA polymerase. what is the biological function of the first alternative structure mentioned above? A-form DNA is believed to be one of the adaptations of hyperthermophilic archaeal viruses to harsh environmental conditions in which these viruses thrive. what differentiates the third structure form the other two? It is a left-handed double helical structure in which the helix winds to the left in a zigzag pattern, instead of to the right, like the more common B-DNA form.
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Z-DNA [SEP] Biological significance
A biological role for Z-DNA in the regulation of type I interferon responses has been confirmed in studies of three well-characterized rare Mendelian Diseases: Dyschromatosis Symmetrica Hereditaria (OMIM: 127400), Aicardi-Goutières syndrome (OMIM: 615010) and Bilateral Striatal Necrosis/Dystonia. Families with haploid ADAR transcriptome enabled mapping of Zα variants directly to disease, showing that genetic information is encoded in DNA by both shape and sequence. . A role in regulating type I interferon responses in cancer is also supported by findings that 40% of a panel of tumors were dependent on the ADAR enzyme for survival. In previous studies, Z-DNA was linked to both Alzheimer's disease and systemic lupus erythematosus.