does it have a business loop?
It was a business loop through downtown Farmington along Grand River Avenue
U.S. Route 16 in Michigan
Business US Highway 16 (Bus. US 16) was a business loop through downtown Farmington along Grand River Avenue. 
from where does the u.s. route 16 in michigan begins? Detroit
wiki:17803417
U.S. Route 16 in Michigan [SEP] Farmington business loop
US 16. The original plans for I-96 called for it to replace US 16 and to run parallel to Grand River Avenue all the way from Farmington into downtown Detroit. In 1959, the Farmington bypass freeway was given the I-96 designation in addition to the US 16 moniker, and the business route was redesignated as Business Loop I-96 two years later.