which actor played the first character?
Dr. Meredith Grey, played by Ellen Pompeo.
Grey's Anatomy
 Dr. Meredith Grey, played by Ellen Pompeo.
when does lexie come in grey's anatomy The character is introduced in season three what features does this character have? Her character has been called "reliable, trustworthy, timid, and apprehensive" .The character has also been described as an "innocent young intern" she knows how to make good relationships was it a series where she appeared? Yes, a  television series "Grey's Anatomy". who directed it? Directors vary by episode, with Rob Corn directing most frequently, followed by Tom Verica. Horton, Edward Ornelas, and Jessica Yu have also directed a substantial number of episodes who all are the main characters in it? Grey, Yang, Stevens, Karev, and O'Malley.
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Grey's Anatomy [SEP] Introduction
Although the series is set in Seattle, it is filmed primarily in Los Angeles, California. The series revolves around the title character, Dr. Meredith Grey, played by Ellen Pompeo. Grey is first featured as an intern and later becomes the chief of general surgery, all the while exploring the ups-and-downs of a surgeon's life. The original cast consisted of 9 star-billed actors: Ellen Pompeo, Sandra Oh, Katherine Heigl, Justin Chambers, T. R. Knight, Chandra Wilson, James Pickens Jr., Isaiah Washington and Patrick Dempsey. The cast has undergone major changes throughout the series' run. At the start of the sixteenth season, the show had a large ensemble of 14 actors—including 4 characters from the original cast (Meredith Grey, Alex Karev, Miranda Bailey and Richard Webber).