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lead poisoning is an example of which factor Risk factors for elevated lead exposure include alcohol consumption and smoking (possibly because of contamination of tobacco leaves with lead-containing pesticides). mention a few signs related to it? insomnia, delirium, cognitive deficits, tremor, hallucinations, and convulsions. The main symptoms in adults are headache, abdominal pain, memory loss, kidney failure, male reproductive problems, and weakness, pain, or tingling in the extremities. how is it diagnosed? Laboratory analysis of the blood lead level (BLL) how is it classified? Acute and Chronic any attention-worthy cases? Yes - 15,000 people are being relocated from Jiyuan to other locations after 1000 children living around China's largest smelter plant were found to have excess lead in their blood. At least 400 children have died from the Zamfara State lead poisoning epidemic which occurred in Nigeria where is the first place located? Northwestern Henan province, People's Republic of China any drugs used to treat the aforementioned poisoning? The chelating agents used for treatment of lead poisoning are edetate disodium calcium (CaNaEDTA), dimercaprol (BAL), which are injected, and succimer and d-penicillamine, which are administered orally. in what way is soil associated with the poisoning? Lead content in soil may be caused by broken-down lead paint, residues from lead-containing gasoline, used engine oil, tire weights, or pesticides used in the past, contaminated landfills, or from nearby industries such as foundries or smelters. what are the medical uses of the second treatment drug aforementioned? Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson's disease. describe in few words about its mechanism? Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme's activity. Dimercaprol competes with the thiol groups for binding the metal ion, which is then excreted in the urine.
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Dimercaprol [SEP] Mechanism of action
Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme's activity. Dimercaprol competes with the thiol groups for binding the metal ion, which is then excreted in the urine. Dimercaprol is itself toxic, with a narrow therapeutic range and a tendency to concentrate arsenic in some organs. Other drawbacks include the need to administer it by painful intramuscular injection. Serious side effects include nephrotoxicity and hypertension. Dimercaprol has been found to form stable chelates "in vivo" with many other metals including inorganic mercury, antimony, bismuth, cadmium, chromium, cobalt, gold, and nickel.