odd interstate routes run primarily north and south
Yes, in U.S.  generally, most north-to-south highways are odd-numbered, with the lowest numbers in the east, and the highest in the west.
United States Numbered Highway System
 Generally, most north-to-south highways are odd-numbered, with the lowest numbers in the east, and the highest in the west.
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United States Numbered Highway System [SEP] Introduction
Department of Agriculture in November 1925. They received complaints from across the country about the assignment of routes, so the board made several modifications; the U.S. Highway System was approved on November 11, 1926. As a result of compromises made to get the U.S. Highway System approved, many routes were divided, with alignments to serve different towns. In subsequent years, AASHTO called for such splits to be eliminated.