is it located on the banks of any river?
Yes Colorado river
Interstate 70 in Colorado
70 enters Colorado from Utah, concurrent with US 6 and US 50, on a plateau between the north rim of Ruby Canyon of the Colorado River and the south rim of the Book Cliffs. The plateau ends just past the state line and the highway descends into the Grand Valley, formed by the Colorado River and its tributaries. The Grand Valley is home to several towns and small cities that form the Grand Junction Metropolitan Statistical Area, the largest conurbation in the area regionally known as the Western Slope. The highway directly serves the communities of Fruita, Grand Junction and Palisade. Grand Junction is the largest city between Denver and Salt Lake City and serves as the economic hub of the area. The freeway passes to the north of downtown, while US 6 and 50 retain their original routes through downtown. US 6 rejoins I-70 east of Grand Junction; US 50 departs on a 
directions to i-70 east from my current location Transcontinental Interstate Highway in the United States, when was it opened for public? October 14, 1992.
wiki:21493860
Interstate 70 in Colorado [SEP] Colorado River
I-70 enters Colorado from Utah, concurrent with US 6 and US 50, on a plateau between the north rim of Ruby Canyon of the Colorado River and the south rim of the Book Cliffs. The plateau ends just past the state line and the highway descends into the Grand Valley, formed by the Colorado River and its tributaries. The Grand Valley is home to several towns and small cities that form the Grand Junction Metropolitan Statistical Area, the largest conurbation in the area regionally known as the Western Slope. The highway directly serves the communities of Fruita, Grand Junction and Palisade.