were there any notable persons guided by him?
Yes, José Rizal and Ida Henrietta Hyde
Wilhelm Kühne
José Rizal (1861–1896), martyr and national hero of the Philippines, learned physiology under Professor Kühne at the Heidelberg University in 1886.

Ida Henrietta Hyde (1857–1945) wanted to study physiology under Kühne at the University of Heidelberg on the recommendation of Professor Alexander Goette at Strasbourg. The University accepted her, but Willhelm Kühne refused to allow her in lectures and laboratories. He is reported to have said that he would never allow "skirts" in his classes. However, when a colleague asked him whether, if at the end of the course she could pass the examination, he would grant her the degree, he jokingly replied that he would. And so for six semesters, she had to study physiology independent of the classroom and of hands-on laboratory projects, using only his assistants' notes and lab sketches. Finally, a four-hour oral examination by Kühne's academic committee, proved her worthiness. The "summa cum laude" degree, the highest honors, could not go to a wo
what is an enzyme? Enzymes are Proteins that act as biological catalysts who discovered it? Anselme Payen was he the same person who gave the name? No, German physiologist Wilhelm Kühne first used the term "enzyme" name some factors that affect it's activity? Temperature, pH, substrate concentration what functions do they perform? Enzymes are known to catalyze more than 5,000 biochemical reaction types what did the physiologist start his career as? He was put in charge of the chemical department of the pathological laboratory at Berlin, under Rudolf Virchow
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Wilhelm Kühne [SEP] Some notable students
José Rizal (1861–1896), martyr and national hero of the Philippines, learned physiology under Professor Kühne at the Heidelberg University in 1886. Ida Henrietta Hyde (1857–1945) wanted to study physiology under Kühne at the University of Heidelberg on the recommendation of Professor Alexander Goette at Strasbourg. The University accepted her, but Willhelm Kühne refused to allow her in lectures and laboratories. He is reported to have said that he would never allow "skirts" in his classes. However, when a colleague asked him whether, if at the end of the course she could pass the examination, he would grant her the degree, he jokingly replied that he would.