what is the role of this metal in biochemistry?
The reverse transcriptases of many retroviruses contain manganese.
Manganese
The classes of enzymes that have manganese cofactors is large and includes oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, lectins, and integrins. The reverse transcriptases of many retroviruses (though not lentiviruses such as HIV) contain manganese. The best-known manganese-containing polypeptides may be arginase, the diphtheria toxin, and Mn-containing superoxide dismutase (Mn-SOD).
what is the oxidation number of manganese in the mn ion It is oxidation state +7. is it a metal? Yes, it is a transition metal with a multifaceted array of industrial alloy uses, particularly in stainless steels. where are these widely found? It is not found as a free element in nature; it is often found in minerals in combination with iron. what are some of its uses? Steel production, additive in unleaded gasoline, dry cell battery.. is it toxic to humans? Yes, exposure or intake may led to manganism, neurodegenerative disorder,  Parkinson's disease. what does the last type of disease mean? It  is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. how is it diagnosed? Diagnosis is based on symptoms, with tests such as neuroimaging. how can it be prevented? Exercise, Caffeine helps decrease in risk, Antioxidants, such as vitamins C and E helps reduction in the incidence of the development of Parkinson's disease. can surgery cure it? No, Surgical therapies helps in 30–60% improvement. are there any notable cases in relation to this disease? Actor Michael J. Fox has written two autobiographies in which his fight against and Boxer Muhammad Ali  the disease, Olympic medalist Davis Phinney started the Davis Phinney Foundation in 2004 to support it, Boxer Muhammad Ali has been called the "World's most famous Parkinson's patient". what is the profession of this world's most  famous parkinson's patient? He is a boxer. where was he born? Louisville, Kentucky. has he won any tournaments? Yes, He has won heavyweight boxing, "Fighter of the Year" by "The Ring",  "Sportsman of the Year", Arthur Ashe Courage Award. what were his contribution in terms of charity? He contributed by donating millions to charity organizations, single black donor to the United Negro College Fund , feed more than 22million people afflicted by hunger across the world.
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Manganese [SEP] Biochemistry
The classes of enzymes that have manganese cofactors is large and includes oxidoreductases, transferases, hydrolases, lyases, isomerases, ligases, lectins, and integrins. The reverse transcriptases of many retroviruses (though not lentiviruses such as HIV) contain manganese. The best-known manganese-containing polypeptides may be arginase, the diphtheria toxin, and Mn-containing superoxide dismutase (Mn-SOD).