why is this city significant?
It is both the state's capital and the largest city.
Mississippi
Jackson is both the state's capital and largest city. 
where is the mississippi highway 335 situated? In central Mississippi. what route does it take? It started at MS 8 and traveled northward over eastern Grenada County. It then crossed Grenada Lake and ended at MS 330. what are some major cities in the state mentioned above? Jackson.
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Mississippi [SEP] Introduction
Mississippi () is a state in the Deep South region of the United States. Mississippi is the 32nd largest and 34th-most populous of the 50 U.S. states. Mississippi is bordered to the north by Tennessee, to the east by Alabama, to the south by the Gulf of Mexico, to the southwest by Louisiana, and to the northwest by Arkansas. Mississippi's western boundary is largely defined by the Mississippi River. Jackson is both the state's capital and largest city. Greater Jackson, with an estimated population of 580,166 in 2018, is the most-populous metropolitan area in Mississippi and the 95th-most populous in the United States.