U kam miqdorda xavfsiz deb hisoblanadi, ammo yuqori miqdorda yetarlicha tadqiqotlar o'tkazilmagan. Qo'shimcha ma'lumot olish uchun AQSh FDA tomonidan berilgan bayonotlarga qarang: [https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.530&SearchTerm=disodium%20guanylate]https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=172.530&SearchTerm=disodium%20guanylate] Shunga qaramay toksik ta'sirga ishora qiluvchi tadqiqotlar mavjud, masalan: [https://www.ncbi.nlm.nih.gov/pmcarticles/PMC
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