JavaScript uchun "eng yaxshi" ramka yo'q, chunki u loyihaning aniq ehtiyojlari va maqsadlariga bog'liq. Hozirgi kunda ba'zi mashhur variantlar React, Angular va Vue.js. React o'zining moslashuvchanligi va ishlashi bilan mashhur, Angular esa keng qamrovli xususiyatlari va kuchli jamoaviy qo'llab-quvvatlashi bilan, Vue.js esa uning soddaligi va foydalanish osonligi bilan tanilgan.
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