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Michael Douglas: American actors today are too 'sensitive' and 'asexual'
By Bedhead
Michael Douglas gave an interview to The Independent to promote his role in Ant-Man. Yep, Douglas is a Marvel man now. If the studio is listening, he wants them to know he's also open to an Avengers film. Just like every other actor in the universe.
Douglas piggybacks here on a recent Guardian interview with Dustin Hoffman, in which the actor said television is king now, and "film is the worst it ever has been." Douglas sort of agrees, but he mainly uses this interview to lament the current state of the American actor. Dude is 70 years old, and he's been acting for 50 of them. He's seen a thing or two, and Douglas believes American actors are too busy "getting caught up in their image" to be masculine:
On manly actors: "There's something going on with young American actors – both men and women – because the Brits and Australians are taking many of the best American roles from them. Clearly, it breaks down on two fronts. In Britain they take their training seriously while in the States we're going through a sort of social media image conscious thing rather than formal training. Many actors are getting caught up in this image thing which is going on to affect their range. With the Aussies, particularly with the males it's the masculinity. In the US we have this relatively asexual or unisex area with sensitive young men and we don't have many Channing Tatums or Chris Pratts, while the Aussies do. It's a phenomena."
The problem with the internet age: "There's a crisis in young American actors right now. Everyone's much more image conscious than they are about actually playing the part."
On Dustin Hoffman's statement: "I understand what he's saying, but I think you have to look at the delivery system. There's a lot of good stuff being made in the cable area, good writing there. Kramer vs Kramer, those great mainline films he was in aren't being made anymore [for cinema] but are in a different delivery system. Most of the great screen writers have gone into the cable area because that's where they can also produce. The problem in making a film for cinema is the cost of distribution. People can scrape together money for a movie but not the advertising."
[From The Independent]
I don't think Douglas realizes how far a little bit of Chris Pratt goes, and there's only room for one of them in Hollywood. But I see what he's saying. Douglas has appeared in so many films, but he sticks out most (in my memory) as the virile adventurer in those Romancing the Stone movies. Back then, there was no such thing as social media. Images were crafted by studios and monthly magazines, not by the immediacy of selfies on the Internet.
Photos courtesy of WENN
125 Responses to "Michael Douglas: American actors today are too 'sensitive' and 'asexual'"
Lilacflowers says:
Is it just me or should Michael Douglas steer clear about talking about other actors's sexuality?
American actors tend to come from two backgrounds. Either they start as children: Joseph Gordon Levitt, Natalie Portman, Ben Affleck, Scarlett Johannsson, Ryan Gosling, Ryan Reynolds, Leo DiCaprio and on and on and on or they were born into the business like Douglas himself.
It's not just you. And my other thought was that having been born into the business, it's kind of rich of him to complain about lack of "formal training" among younger actors. As if that's all it took for him.
kori says:
Even wi th his an backround he did spend time studying acting in nyc. He took bit parts until his breakthrough with Streets an of san Francisco. Then he acted intermittently as he focused om produing. It was Romancing the Stone which brought him back full time.
JenniferJustice says:
So he did some formal training, but his path was still paved for him. His father was a mega-star in his generation and rich beyond our comprehension. Michael's college was paid for by Daddy and Daddy had connections. I can't hear how Michael made his own way because he did not.
As for any talk on sexuality, Michael was a known cheater. I guess his thought process is that if you're not boning every female willing to let you, you must be immasculine. Speak for yourself Michael. You're only explaining your own subconscious motives. Freud would have a hay-day with you.
Emma - The JP Lover says:
@Esmom, who wrote: "It's not just you. And my other thought was that having been born into the business, it's kind of rich of him to complain about lack of "formal training" among younger actors. As if that's all it took for him."
Michael Douglas studied theater in college once he left his hippie life behind and got serious. Then he moved to New York and struggled just like hundreds of other actors and paid his dues. He and Danny DeVito were roommates in New York City while looking for acting jobs and waiting for their big breaks … and they have remained close friends through the years. Danny DeVito met Rhea Perlman during this time.
Young actors today snub struggling for acting jobs in NYC in between acting lessons with noted experts. But that was sort of a rite of passage for young actors in the 1950's and 1960's.
Kiddo says:
It's just YOU. I long for more manly-man actors who blame oral cancer on their wives' vaginas.
That, to me, says Hetero-rrahhr-mucho-macho, not too much sensitivity.
To be fair, he didn't blame his wife. He said the doctors told him that his particular type of cancer is caused from a strain of HPV and that the throat cancers are due to oral sex.
I think most people are aware that Michael Douglas was a bit of a womanizer throughout most of his adult life and he could have picked up the virus from any number of women.
It also takes a number of years, apparently, to become cancerous, if it does so it's even more likely that it was someone in his past. I, for one, didn't think for one minute that he contracted it from CZJ.
KAI, I was aware of the nuances on his statement, and I understand the pathology and transmission, and no one knows what brought on his cancer specifically, …still it was incredibly tactless.
Cleo says:
OMG +1,000,000 LOL
To Kai, he knew exactly how it played – why he felt he had to 'splain the possible origins, one can only surmise…I think he was passively aggressively attacking his wife… theyve been close to splitting, amd were separated around that time – but he knew how it would be received because the public DID think he was blaming CZJ.
@Cleo You are making assumptions about someone I am quite sure you don't know. What I remember is what he actually said and then how the tabloids ran with it. He NEVER blamed his wife.
Denisemich says:
Hmm. I thought he hit a point regardless of whether it came from a privileged view.
Now actors can't seem to separate the character they are playing for the media from the character they are playing on screen. Isn't George Clooney basically the same character in everything he plays and seemingly in real life. Isn't Jennifer Aniston the same character in everything she plays and seemingly in real life.
If you ever saw some of JLos early work, she was a good actor. I mean G. Clooney and her hate each other but those love scenes were HOT. Now, all her movies are crafted to match her image. It seems like she can't act anymore.
Longwinded but the point is. Branding has created product endorsement money and power for actors and in some cases overshot their actual careers.
Michael Douglas seems to believe that if they had better training in acting they would be able to separate the character they have to play for the brand from the character they need to play on the screen.
Horseradish. He just longs for a time when men were mens' men. You can't tell me that during his father's career, he didn't play EXACTLY the same role, over and over, and that branding as a masculine man didn't play into it, with studios directly controlling the image and presentation to the masses.
GoodNamesAllTaken says:
I agree. He hears men today saying they are feminists and he's pissed because he can't call us broads anymore.
@Denisemich & Kiddo I agree with both points, he seems to have falsely equated the two though. I'm not one for the celebration of hyper-masculinity and I certainly don't pine for that lost time when "men were men" (Sean Connery casually slapping women about in the early Bond films comes to mind) , but I do think that a number of actors spend too much time crafting their brand image rather than crafting actual talent.
But there has always been such branding. Clark Gable. Cary Grant. Gene Kelly. Kirk Douglas. None of them lost themselves in the roles. Rock Hudson played the same role on and off screen.
While Douglas may have some valid points about training, (and he did study acting) is he doing anything about it? He's a powerful man. Is he going to endow acting scholarships or is he just going to whine that people should stop hiring the foreign guys?
That has always been the case with actors, except that the studios used to do this for them. Now they have the autonomy to do it themselves, for their own direct benefit, rather than the studios receiving sponsorship. And maybe some of them are closer to the chosen personae in real life than what studios previously crafted for them. There have always been actors versus movie stars. The movie stars need more in the way of buzz, than do the real thespians.
But Celebrity was never 24/7 before. With the advent of social media things have changed.
In the past, Actors were the brand for a movie and weren't so scared to have an opinion. Now everything you say and post has longevity.
True Lilacflowers, but as Kiddo pointed out that was when studios had much more control over their stars. Back in the 30's – 50's studios simply would not have made you a star if you weren't willing to follow their branding to the letter. Actors still have to promote themselves today (especially if they want the big bucks) but there does seem to be more freedom as to what level of exposure and branding they can opt into, and plenty seem to revel in that aspect more than in honing their craft.
And yes, although all the actors you mentioned had a "brand" so to say, they also spent a significant amount of time in their early careers on stage (with the exception of Rock Hudson), many working their way across America in local theatres before landing in LA.
ETA: I think another important distinction is that roles are much more diverse now than they were then. There does seem to be a greater opportunity now for actors (men mainly) to play different parts and yet many would rather turn down controversial roles for fear it will damage their image than seizing the opportunity to diversify.
I think he just yearns for a time when HE was a 'man's man,' and a hot leading man, because HE NEVER WAS.
Ipso facto and as a result, American movie stars like Clooney, Pitt and DiCaprio he enjoys passive aggressively slamming. Not that he luuuvs fat Russell Crowe or Foppish Colin Firth, he just likes using them as tools to poke the American movie stars whose careers he NEVER had, even in his heyday.
He was a TV actor, and he costarred in a couple good movies where he was not the lynchpin (China syndrome w/Jane Fonda) He was good at playing morally bankrupt types in films like Fatal Attraction and that other one – but most if the time, it centered around the women (Glenn close, Sharon stone) and they were the ones who stole the show.
Face it, Douglas was never a Pitt or a Clooney or a Russell Crowe or a Jack Nicholson or a DiCaprio or even a Damon. He was barely an Affleck.
When he makes these remarks I always inevitably feel he's just lashing out at much younger American actors he envies.
I haven't forgotten the comment he made when Brad Pitt blew the world up getting with Angelina.
Something about 'why's he divorcing Jennifer to go adopt orphans with Angelina.' Nevermind that he didn't even know them well, if at all, and it wasn't his business. He managed to show himself as a douche (no surprise to anyone) and insult their children making it seem like adopting, and adopting orphans at that, was so not worth it.
That was a POS move on his part that he TRIED to backpedal.
I always thought his remarks stemmed from Brangelina totally eclipsing his may Dec relaysh with CZJ that no one cared about – perhaps he was miffed that no ine gave an ish, what his kids looked like and still don't.
He's the type that would be bothered by that. Like..waaah..my wife is hot…my kids are cute…what about meeeee. Lol
Maybe he can address why his other kid turned out to be a drug dealer and is doing time, instead of passive aggressively slamming American actors he's jealous of. He has issues, and I feel bad for his eldest Cameron.
@Clea, Michael Douglas has a Best Actor Oscar
BlueNailsBetty says:
He has always pinged on my gaydar.
Maybe bi? There were rumors from the Liberace HBO film, IRIC.
What rumors, exactly?
Considering that he's a guy who once claimed to have a "sex addiction," I think the answer would be *Hell to the Yes.* Alternate answer: *Hell to the F**king Yes.*
who are those sensitive men though? maybe Gosling. the rest is mostly beefcake and i can't even tell most of them apart. just a week ago i learned Captain America and that Pratt guy are diffferent human beings.
the looks of the leading men havent changed drastically. its more muscle nowadays but they were, apart from a small period with Hofman, always tall and handsome. i guess back in the day it was focused more on talent, nowdays its mostly only about their sex appeal.
jinni says:
Ha, at you thinking Evans and Pratt were the same person. I use to think Patrick Wilson and Pratt were the same person. Pratt has a very generic face which is why I don't get the hype around his looks.
But, yeah, I agree with you.
Also, I don't find the new batch of Brits that have come over here all that traditional masculine looking or acting. Most of them look frail. Besides every couple of years an influx of Brits and Aussie come over and the film industry is charmed by them but most don't last, especially the Brits (at last it did seem to work out so well for the last batch they sent over in the mid-late 2000's). Americans seem to like the Aussies better, probably because they have a stereotype of being a little rough around the edges which Americans seem to like more.
ah good point i forgot about Eddie Redmayne or Andrew Garfield but yes they are certainly the sensitive fragile kind of guy.
their roles called for it though, Spiderman in "real life" is not a beefcake.
Timbuktu says:
Which Brits didn't do well from mid-late 2000-s?
we also have Hugh Grant and that dude who was in "About time". But I feel like Brits have never banked on pure looks, it's always about being quirky and deprecatingly funny. And it works, on me, at least.
Timbuktu: Clive Owen for one. He was supposed to be big in the states and did bunch of movies, but never really took off.
I don't know, I feel like he was a big deal for a while, not sure many Americans keep their sex symbol status for much longer.
Kitten says:
Hardy is pretty damn masculine-looking.
Yum…Hardy….
Camille (the Original) says:
And Fassbender…
Paul Ó Duḃṫaiġ says:
Fassbender ain't a Brit though.
BangersandMash says:
I'm just here to send a shout out to that super hot guy fresh out of an oven in Sydney.
Joel Edgerton, you get every damn role you can get. Straight up snatch them you masculine, sexy, thunder from down-under!!!
Ok. That's all!!!
Palar says:
Love that you think he's fresh out of the oven, he's been very well known to us Aussies for over 15 years! Glad that he's now getting success in the US as he's a hugely talented guy.
Oh, I love this. hehe.
maybeiamcrazy says:
I always thought it was the opposite of what he is saying. American actors want to be buff and manly. They are better looking than their British counterparts but Brits are more intriguing. I don't think American actors are more sensitive than British actors. It is just American actors tend to be very similar. I agree with you, there are shit loads of Chrises and i can't tell them apart. That is the biggest problem of American actors, they are more of a movie star than character actor. I would rather watch James Mcavoy or Eddie Redmayne. I don't know what the reason is, there are many great American actors, maybe they should weigh on this issue rather than Michael Douglas.
I like, okay love, Cillian Murphy and Daniel Day Lewis. But it's not because they're 'manly,'- they can play that, for sure…but it's their sensitivity more than being walking testes.
That's about it. Can't think of any others.
No one can tell me Pitt and Norton in Fight club could have been replaced by Cumby and Firth or the hemsworth lugs. Just stop.
I'll give him Russell Crowe, about 75lbs ago..no one could touch him – Gladiator – who else could have played that…..and if he didn't have a personality from hell, he'd be working more today, fat or not.
me too. but perhaps I'm not paying close enough attention.
Aussie girl says:
There is no disputing that America is where the movie scene is at. Is it so terrible that a Brit, Aussie or any nationality takes a role..? I realise that it's ideal because who wouldn't want jobs to go to people in their own country. But America is the place where actors go to get that big break and the stories ( movies) told are not all American. Idk I just don't see the big deal & think that it should be viewed as been super proud that actors strive towards their big break in America .
But I understand where Michael is going. Previous batman was a Brit and fought against another Brit in the dark knight.
"Masculinity" whatever you want to call it or define it in modern day cinema terms is geniunely being taken over by the Tom Hardys, Idris Elbas and Chris Hemsworths or Joel Edgertons (I love you Joel!!! Get all those roles) while the Leo Dicaprios and the James Francos are going for the less physical stuff.
I suppose it's a redefinition of masculinity. The kinda (for lack of better word) "man's-man" manliness is open to men from other countries to pursue. It's a wonderful thing.
MildredFierce says:
The problem is the Aussies and the Brits don't return the favor. They don't hire Americans – I can't think of one BBC show or any show that has state funding to hire Americans.
So in essences the Aussies and Brits take advantage for both industries. Americans only have Hollywood and yes it thrives because of good ol' Merican Capitalism.
skedaddle says:
@MildredFierce
what? Just off the top of my head, I can think of two Americans starring in British TV:
Gillian Anderson is the star of the one of the highest regarded BBC shows, the Fall, and she's American.
I've been watching Humans on Channel 4, and William Hurt stars on that, also America.
boberta says:
What about Maggie Gyllenhaal in The Honourable Woman? Andy Samberg and Taylor Lautner's stints on Cuckoo? Robert Vaughan in Hustle? Jeremy Piven in Mr Selfridge? The various TV productions David Soul has done, like Holby City and Inspector Lewis? What about Paul Giamatti, Elizabeth McGovern and Shirley Maclaine in Downton Abbey? I'm fairly certain Richard Gere was in The Second Best Exotic Marigold hotel, too, and these are just the ones I can think of as I sit here. Plenty of American actors, incl. big names like Kim Cattrall and Jake Gyllenhaal, can be found working in the West End as well…
Maybe the numbers don't equal those of Brits getting roles in the US, but our industry is smaller and structured differently, and Hollywood has been an international "Mecca" for the film industry for close to a century. Hollywood is where you go if you want to be a movie star and I can't help but feel that for a lot of American actors their desire to be an actor has as much to do with being A-List as it does with actually acting. Working outside of the US industry is less likely to see them get to where they want to be whereas in Hollywood it can perhaps seem a more achievable dream. Even over here you're not seen as having truly "made it" until you're jetting off to LA; after all, isn't the US meant to be the land of opportunity? Our film industry might be out of it's "dark/crappy" period and Australia's is certainly making huge leaps and bounds in terms of output quality, but Hollywood is still where the studios and money is. It only seems logical that an actor from the UK or Australia is going to try their luck there as much as an actor from Chicago or Nebraska or California would. Whether they succeed or not is down to their talent, attitude and training. I'd say ten times as many Brits fail to make it in Hollywood compared to those who do manage to get a role in something.
Sixer says:
Isn't it mostly because film and TV are global industries now? You can't have the bulk of the global market share in an industry AND be parochial any more (ask anyone working in finance in London – they'll say the same). It's as simple as that. I mean perhaps the US industry needs to think about stopping producing so many cookie cutter actors who promote themselves as products rather than actors with diverse portfolios in this environment, but it's the environment that counts.
I really don't think calling all male American actors sissy boys (in so many words) is going to help matters, Michael, you ridiculous old homophobe.
Also Brit and Aussie guys who have had success in this age group would of been paid far less them American actors with similar resumes so someone like Marvel can offer them a contract for many films on a much lower pay scale.
That's a very large part of it now. They market everywhere and the industry is going to pull actors from everywhere as a result but as I said above, many of the American actors getting steady work today started as children or, like Douglas himself, are from families with strong ties to the industry.
Lilac – that's kinda your version of our "only the poshies can afford RADA" problem, isn't it? You've got the intra-industry preferential stuff, ours is extra-industry, as it were.
I do think other factors are at play, of course. Even so, the main thing for actors of all nationalities now is to learn how to compete in a globally-selling environment. I guess aiming at being the actor who will be acceptable to US advertisers in breaks on US network TV shows isn't the best tactic any more?
Yes, Sixer, exactly. We are a huge and wealthy country but few kids have access to arts education. Art and music tend to be the first items cut in school budgets and teaching to the test in English class doesn't allow for much exploration of the dramatic arts. Football teams get saved while the school drama clubs get eliminated. Regional theaters are few and far between in large sections of the country so that training ground doesn't really exist here. Many actors like Julianne Moore and Kevin Bacon trained in soap operas but those are now gone. While commercials were the training ground for Travolta and even Brad Pitt.
LAK says:
Sixer: the product thing is what he is talking about. social media image thing is about positioning yourself to sell product. The emphasis on brand vs acting.
The American actors want to be brands irrespective of acting chops. That's why being a superhero is important to them vs a Brit or Aussie doing shakespeare (yes I know also a brand, but emphasis on acting). And the superhero genre had to prove itself before american actors finally jumped on the bandwagon. Most superhero/action films were populated with foreign actors going back to the dawn of cinema.
To be fair, his comments are nothing new. There is also the ongoing decades long refusal of american actors to take baddie roles because it affects their brand/american audiences. They always want to play the hero/anti-hero. Ditto roles the require being ugly if no chance for an oscar. It left those roles open to foreign actors, particularly the Brits.
The american actors who genuinely want to act seem to be in theatre and in indies (or studio indies) and refuse to play the branding game – Joaquin Phoenix. I'm impressed Bradley Cooper is treading the boards. It shows he wants to be an actor with range, not just a product.
As for him making these comments, people forget that MD started out as a producer before he became as actor. He continues to produce even if he isn't in front of the camera, so his comments are borne from experience.
Not a big fan of Bradley copper but it shouldn't be surprising as he is every bit as educated and trained as his British counterparts. Cooper has an academic degree (Georgetown university) And trained at the actors studio, the new school, After that.
Yes, he has been a producer for much of his career but acting in Streets of San Francisco came before producing One Flew Over the Cuckoo's Nest.
LAK – fair enough. See what I said to Lilac above.
Funnily enough, the actual *product* of this industry that I'm interested in is really the parochial one. I don't care much for all the international blockbuster stuff. So I enjoy Nordic noir, for example, because it's telling stories from a parochial (in this case Scandinavian) point of view. The TV show I've enjoyed most of late was Netflix's Bloodline, which I'd see as a piece of quintessential American storytelling (and yes, I know one of the leads was an Aussie).
So in that sense, I do agree. I think if American actors stopped aiming at being global box office/TV advertiser acceptable products and thought more about establishing varied portfolios, they would be in a better position to get more of the plum roles. Counter-intuitively, this would probably include the blockbuster roles, because the industry is changing and the American acting profession doesn't seem to have caught up quickly enough to the changes.
Anne tommy says:
I saw Bradley in The Elephant Man in London last Saturday, from the front row, great performance.
He's just repeating a Theory that came from THR (I think?) a few years ago. Which broke down to that casting directors where finding it hard to cast roles for action films/comic book style beefcake roles because young 20-30 male American actors tended to be a slighter more delicate looking.
The two possible causes I've seen mentioned is in other English speaking countries boys are encouraged at school to be both sporty and do Drama and in America you tend to do one or the other at high school. I'm not American so don't know if that's true or that young actors that have had success before like child actors or teens tend to be more cute looking.
Good point about American students choosing either sports or fine arts but generally not both. That's very true. There are exceptions (one of my sons is one of them), of course, but most jocks steer clear of the drama kids and vice versa.
American schools also tend to fund sports programs but not arts programs.
but the typical english actors are not very sporty or build. And Liam and older Hemsworth are not drama students thats for sure lol.
hes right about English actors, most British actors are classically trained, they spent years in a conservatory and many have been doing theatre before they arrived in Hollywood. There are American actors who take their craft seriously, but I think at the time Hoffman and Douglas were big American actors really defined the medium with inventive original performances. Not so anymore. I am sure there are American actors who are as masculine as the helmsworth brothers and Russell Crowe however there seems to be a preference for more effeminate pretty boys in cinema right now. Nothing wrong with that but you don't have the variriety of leading men that where present in cinema in the golden age of Hollywood ( the 70s). In those old movies you see leading men like Hoffman, pachino, Hackman. These actors would not be considered pretty enough to be leading men in this day and age.
Hoffman and Pacino also wouldn't fit Douglas's view of being manly men.
I read the interview over at another site he didn't just talk about manly men. He talked about the importance of acting training too. It was a little more nuanced that what come across in this post.
he personally also never came across as a manly man to me.
Neelyo says:
Personally, I think what Douglas is trying to say applies to the new crop of Brit actors. I know I better duck but I find Hiddleston, Redmayne and Cumberbatch very 'sensitve' and 'asexual'.
jen2 says:
I'll get under the table with you. I would add, and I love them to pieces–Fassbender and McAvoy (both of whom I would call "sexy"). All of these guys would most likely get blown away in a strong wind. Good actors, and good looking, but old school "masculine", (I am thinking Gregory Peck masculine–tall, deep voice, gorgeous), probably not.
serena says:
All that^. Golden.
Redmayne, Hiddleston and Cumberbatch are some of the most disturbingly sterile, asexual and gender-neutral celebrities and men I have seen in a long time. They are not effeminate, because even with effeminate men, you can pinpoint and actualize some sense of sexual identity.
I personally find the likes of Tom Cruise and Mariah Carey extremely asexual. Meaning no matter how hard they train at the gym in Tom's case to perfect his body or how consistently they wear slutty outfits in Mariah's case (topped with the over-the-top feminine drag queen persona), these two will always come off as asexual to me.
p'enny says:
do you guys know what asexual means? it mean someone has no interest by genetics, not choice, in sex at all.
Considering two of them are married, i think they are not.
True but isn't he saying about the Brits that they are better trained. I don't see him pinpointing Brits as masculine ( although there are British actors such as Elba, hardy and Craig that are more traditionally masculine) I feel like he's saying British actors beat American actors at the art of pure acting whereas the current crop of Australian actors have that more typical masculine quality that we used to associate with American actors.
Britain is small. It's a lot easier here to establish a varied portfolio – you can be based in London and only need to travel a couple of hours to appear in high quality regional theatre, for example.
I dont buy that it's about size. In the golden era of American actors they were classically trained too. If you look at the great actors of modern American cinema the majority came through the actors studio or Julliard or some kind of conservatoire. And you'd find that a vast majority worked in the theatre before they made it in Hollywood. The training and pursuit of the craft most definetly plays a part. It's like any profession you become good by taking it seriously as an art form.
Naddie says:
I think it's a social tendency, the concept of gender is changing. Nowadays we don't have the "masculine" or "feminine" type like decades ago, at least not so defined. But I agree with him and Julie, talent is not the main focus, unfortunately. Anyway, he knows better than me, I'm sure.
Mia4S says:
Come on Michael, America still has three out of four Chrises! (Pratt, Evans, and Pine…then one Aussie Hemsworth).
Seriously though I think what casting directors like is the training. It's not like the bottom reality-show level tier is being brought over.
No new actor coming to Hollywood – white, black or Latino – should go by the name 'Chris' anymore. Not one. Especially if they are tall, all-American looking and white.
– Use your middle name.
– Come up with a stage name.
– Use your father's name.
– Use Christian or Christopher – if you MUST. (I'd say use 'Topher' but that is a very silly name imo.)
But NO MORE CHRIS.
These 'Chrises' are everywhere: they all look the same and none of them are anything that special in the talents or looks department.
In the Aughts it seemed like there was a new Jessica every year. Simpson, Alba, Biel… each more untalented than the last.
I know I'll get hated on for saying this. but I agree w/ Michael.
Today male celebs are all 'Ellen'-ized. They all go to Ellen, show off their well-sculpted torsos, and talk about their children and wives. Being a father or a doting boyfriend/fiance/husband – as a concept – has overtaken the male moviestar persona.
The days of old when Hollywood stars were perceived as drunk, over-sexed, scandalous and mysterious type of creatures, things were different. people did not ahve smart phones to record everything. The likes of Liz Taylor or Jack Nicholson could not have sustained themselves today. People online would hate on them for being sexually promiscuous, lascivious and materialistic. And studios would drop them.
All American actors – male and female – are too sterile and asexual now, because they are afraid of being judged and perceived as a 'menace to society' by coming off as misogynistic, racist, sexist or too self-involved. Studios do not approve that. That is why they never talk about anything substantial in their mag interviews nowadays.
It is all about their kids, wives or how hard they trained to perfect their muscles.
Anname says:
I agree Serena – we know too much about their real lives, so the mystery is completely gone. Even those who attempt to not sell their personal lives get papped and twittered about and sneaky fanpics pop up online all the time.
Keaton says:
I agree with this. Asexual. Safe. Bland. Kinda boring.
That's how I'd describe the current crop of young American male actors.
And like MIchael Douglas points out – at least the Brits have training. Many of them maybe asexual too but they can act! Most of the young American male actors really can't.
Jayna says:
Bland, that's the word.
No hate at all, but I see a very negative effect on the old days. The celebrities were somewhat "untouchable" and this creates an illusion about the human being they actually are. It just might backfire, I take Rita Hayworth as an example. Also, it's good that these famous people are watching their back more, since they're overpayed and not above criticism. Anyone should be called out for being sexist, racist or misogynistic.
However, I can also see a negative side on nowadays too, with the over exposure and the consequent lack of authenticity in their interviews.
I agree wholeheartedly about the benefits of this newly-utilized transparency we get to enjoy, because I too do not wish to support the careers of performers who are simply terrible people.
Bye Cosby! Bye Mel! Bye Sean Penn! Bye Cruise!
But why do they all have to be so monotonous and sterile ALL THE TIME??? So eager to become a part of the norm?
We love seeing famous women naked in mags for instance. We think it is either sexy or empowering. But men? No no no… They will never do a naked/half-nude shoot just for a fashion magazine! It is unthinkable. Their wholesome/manly image would be shattered. Or they would be laughed at, because self-possessed men don't do nudity! They are not vain like that! They are vain in other ways – like romancing 22 year old girls when you are 52. That is acceptable sort of vanity that make men still look manly and somehow bland and run-of-the-mill simultaneously.
It is a bore and imbecilic imo.
I guess in the end of it all, it's a choice between bad and evil. It's not good like it is now, I agree, but old Hollywood wasn't as well. We get rid of one trap to fall into another one.
Christin says:
I also think we are in an information overload sort of society, with social media and daily access to new information.
These newer actors are familiar to me by name only, because no one has the time to read every word or see every photo of all these current celebrities.
At least with weekly or monthly publications of years past, it was easier to digest the who's who of entertainment.
And let's face it – few of these names will actually get to do some acting work that deserves so substantial widespread attention. Male or female btw. I am not excluding the current female talent from these crappy and irrelevant careers we see today. It is highly ubiquitous.
Absolutely says:
It's all just image though, isn't it? Image has never not been a part of Hollywood. You're lamenting the 'asexual' image of modern movie stars, but back then the studios had a much more micro-managing view toward their stars. It was just that the images were very stereotypical masculine/feminine roles. All the men were beefcake hyper sexual hetero men, when in reality a lot of them were hiding homosexuality. All the women were either extremely made up siren types or sweet girl next door types.
We've moved into an era where we have dispensed with a lot of these stereotypes and Hollywood is a reflection of that. It may make more of a more "sterile" image, as you say, with some people, but if you notice, I think most of those with that image tend to be more serious actors. I think it counteracts the 'real-ness' of all the reality tv stars and such.
Yes but look at the way we are looking at Ben Affleck or Jon Hamm now. They are still angels compared to someone like Jack Nicholson.
I am not saying one is better than the other. I am just observing the situation. This wholesome 'Ellen Show' friendly image has overtaken the land. It is either the Brad Pitts or Ben Afflecks or Channing Tatums or Chris Pratts who will go on these shows and interminably talk about their children and wives etc. When in reality, not everything is all that nice and dandy – look at Ben Affleck's life now.
Or it is the Jake Gyllenhaal types who will talk about how much they WANT to be parents and husbands and they are just looking for the 'right gal'! Or the Henry Cavill who only talks about how much he pumps and lifts @ the gym for that dumbass Superman role.
No one presents an element of danger, decadence or disturbance. It is scarily bland, robotic and one-size-fits-all.
This 'Stars… they are just like us' thing has gone overboard. They do not have the talent to counteract and buffer this level of blandness. We are fetish-izing the concept of wholesomeness, having a family, reproducing and being so safe so that you will not have to apologize for anything.
It is the Colin Farrell before-and-after situation.
Those days of Hollywood, that played out like some Jackie Collins novel, are gone. Now they all talk about loving to play PalyStation with their pals and hanging out with Jimmy Kimmel or Jimmy Fallon in family picnics!
They come off sexless and one-note and that does negatively affect the way we perceive them as performers.
But back then studios were in control of their images. Of course we know now that everyone was screwing everything in sight and taking as many drugs as possible, but you don't think Rock Hudson was talking about that in interviews in Harpers Bazarr do you? Everyone in Hollywood has always had an image. It's just that now with social media it's easier to out them.
Esmerelda says:
@serena, I understand what you're saying, but I think it's all part of a generational trend: I've been reading that young ppl drink less, for one. And have you noticed how there are no more tormented, self destructive rock stars around? I think the public simply wants and likes more wholesome role models.
We oldies of course miss the glory days.
@Serena, long before there was Ellen, there was Merv Griffin and Mike Douglas and Steve Allen where actors would go on afternoon talk shows and chat about their lives. Ellen is nothing new
bns says:
I'm late, but I agree.
Mispronounced Name Dropper says:
Loved him in The Game.
He's not really making much sense, is he? The rational part of his argument (brits have better training, US actors are just image obsessed) I can understand, but the other part (aussies have the looks, US actors look asexual) sounds a bit random…. I mean, can you tell the nationality of Thor from his looks?
And Douglas himself never really looked beefy or masculine… just handsome and slightly dangerous, but he was no beefcake.
It's like he began talking one way and then went off on another tangent. I agree. Douglas did have gravitas on the screen and a masculinity, not a beefcake, and turned in some strong roles in some great films. I got what he was saying about many actors not as dedicated to their craft here and more so their persona and popularity and thus not working on range in their acting, but then he lost me with Chris Pratt and going off in another direction.
He lost me as well. It's a bit rich to be talking about the lack of proper training for American actors and then in the same breath lamenting that we don't have more actors like…Channing Tatum?
I've said for a while there's a dearth of actors who come across as men, not boys playing parts. And the part about being trained for your acting profession and caring about the roles and not the publicity, etc., is true. There's a reason 60-year-old Liam Neeson became the face of box office hits and the go-to guy for action thrillers. He has the physical presence of a man who can do that role, but the man can also act and thus brings gravitas to his roles. The Grey shows that. Several of these parts were written for much younger men, but they rewrote the roles for him. And he is a man doing the job, not a boy.
That may be due also to the four quadrants thing? Like, we love to see a man doing a man's job, but to a teenager it may look like 'old man on screen'?
I guess the audience for Liam Neeson action movies (or the expendables, or possibly even Bond movies) is limited, that's what I'm trying to say.
Liam won me over with his portrayal of a backwoods Kentuckian in Next of Kin years ago. He nailed that role and had a completely believable accent. I haven't followed many of his roles, but that one convinced me he was a very good actor.
In comparison, his onetime GF Julia R did that dreadful Mary Reilly (her attempt at an English accent was dreadful).
funcakes says:
Julia hovered between a British and Irish accent. But managed to turn in a good performance.
Leo DiCaprio also attempted an accent and should never do it again.
'Michaed Douglas says, "American actors are too sensitive and asexual,"' says the man who played Liberace.
He is talking about their persona, not the roles they play. Not everyone is going to have the chance to play some oversexed macho man.
And Liberace was an extremely sexualized role. That whole movie was about a man's sexuality. Nothing like that can be deemed 'sterile' – straight or gay.
OK, I was going for a mild joke, but apparently I missed the mark, widely.
I don't think he's just talking about beefy, built up guys when he refers to "masculinity"
I think he's talking about a certain attitude, danger, assertiveness, etc that seems to be missing from the images of lots of young American actors nowadays.
They're not just asexual but they're quite safe and bland IMO. At least the Brits can act.
Yes, that's how I interpreted it too. Like, Chirs Hemsworth is bulky, but there's no assertiveness on his persona (yeah, I know he's not american, but you got my point).
manta says:
I totally thought that was what he meant (masculinity not the same as beefy )but he lost me with citing Tatum who, at least to me is the asexual hunk.
I took it that at one point Hollywood had room for the likes of Mitchum, Bogart, John Wayne or Bronson,Bogart, the masculine types but not GQ material or first pick for a Dior campaign or a Armani endorsement. I'm not sure they'd be given a shot today.
The Brits employ Brendan Gleeson, Ray Winstone, Stephen Graham, Eddie Marsan etc… Sure they won't get a call from Tom Ford or Men's health anytime soon but I'm sure they don't lose sleep over it. I'm under the impression these things matter more for US actors (at least the ones getting their break now)
I think what it all boils do to is there two categories:
Movie Stars and Actors
Movie Stars burn bright and burn out barely seen again. Remember the Brat Pack.
Then there are actors who get very little press but manage to get all the work. A great example is British actor James Frain. He's in everything and have been acting for over twenty years. No role is to small. What keeps him working is the fact that barely anyone could pick him out of a line up.
FingerBinger says:
Michael Shannon,Sean Penn,Daniel Day Lewis J.K. Simmons and John Hawkes are also in that category of actors not movie stars. Denzel Washington is in the rare category of actor and movie star.
JK Simmons is in a category all his own. I've been watching him for years and he never disappoints. Ditto for Shannon.
There are plenty of actors in America that have great training. Those just aren't the people hired for film/television. Everyone has to look just 'so'. If you aren't young and slim and perfect and botoxed to within an inch of your life, you aren't getting that role. The advantage that Brits have, in addition to their training, (and I hope this continues) is that british television and film tend to hire actors that are best for the part. There are normal looking people on british tv. There's a seemingly normal mix that's reflected in society of good-looking, average, and not so great looking people getting parts.
It's quite a relief to watch Brit film. You aren't so distracted by everyone looking so perfect that you're sat wondering, how do all these people look so strangely alien perfect?
Nah. I definitely don't think we have a deficit of "normal-looking people" on American television.
Look at The Sopranos, Nurse Jackie, Better Call Saul, The Wire, Orange Is The New Black, Fargo, etc–and that's just a small sample. Many of the stars of these shows are relatably average-looking.
To add, American television is probably the best it's ever been. We have a lot of really well-made shows with increasingly diverse casts and hopefully we'll continue with that trend.
I think what you're saying might have applied 20 years ago, when we relied on network television for our programming, but ever since HBO's Sopranos changed the landscape we really have a lot to choose from. So many good shows that I actually can't keep up!
It's gotten massively better in the last 10 years. But there's still a lot of uglying up of pretty people, especially women. I still think it's easier to get jobs in Britain if you aren't at least an '8' than it is in the U.S.
Yeah a great example of the "uglying up" is Rachel McAdams on the new TD. It's hilarious, like "let's give her really bad hair and no makeup and maybe that will distract from her flawless skin and perfect face!". It's not working, guys.
That might be true. I guess I don't watch enough British television to give a fair assessment. Either way, it's changing for the better here I think.
It is. I agree.
i agree with Absolutely with british series (i dont watch many british movies) its a lot more regular looking people. tv is generally better for ugly but talented people, in movies you have to be super good looking to get parts. like ugyling up women or Logan Lerman as an awkward guy who couldnt get dates LOL!
it also seems if the subject matter is more intellectual and challenging the looks of the actors matter less. Bryan Cranston is an attractive man (and crazy good as an actor) but he wouldnt be allowed to lead a big network tv show for example, or Phiillip Seymour Hofman wouldnt have been allowed to lead a summer blockbuster.
its really a shame its so much about looks in Hollywood but the audience plays a big part in it and good looking people are easier to market as the interest is way higher.
I agree with you, particularly with your second paragraph.
Again, I think the inception of HBO and The Sopranos really forged a path for great, well-written, well-acted shows with a lot of character actors, who might not be gorgeous, but have loads of talent.
Pre-HBO we really only had sit-coms and legal/doctor dramas to choose from.
Another thing that's worked in our favor is mainstream film actors crossing over to TV, whereas in the past, TV was considered a failure–a last resort–if you were a film actor.
EN says:
> It's quite a relief to watch Brit film. You aren't so distracted by everyone looking so perfect that you're sat wondering, how do all these people look so strangely alien perfect?
Exactly! Watching US movies is like being transported to Elysium. Everyone is so perfect, it is disturbing.
Yes. If you are talking about blockbuster films, but there are tons of indie films that feature regular-looking people. I swear. I'm not making it up..lol
renee28 says:
The US may not have as many institutes churning out trained actors but there certainly are trained actors making a name for themselves. Chadwick Boseman, Dane DeHaan, Adam Driver and Oscar Isaac just to name a few. For better or worse in the US there's more opportunity for actors to get their start without formal training. And besides training doesn't necessarily mean talent.
I love Oscar Isaac, speaking of which it seems most really well trained US actors are coming out of Julliard.
I just don't understand why so many mediocre actors are hired ahead of them.
I think it might the issue of the looks vs. talent? In the US people expect to see only perfect people on the TV or in the movies. Often a pretty face wins over a talent and training.
I know few Deniros and Pacinos will ever come along again (although their later work has been a cash grab). At least, Al is back doing some great roles again. I didn't realize he had lost millions, so probably why he took a lot of crap later on, and at a certain age not being offered great roles.
But The New Yorker last year ran a long feature on Pacino's career interviewing him. Reading this interview and the author of the article delving into Al and his climb to becoming one of the acting legends of any generation made you realize how there are few out there like him, that have this innate brilliance for the art of acting early on and truly revered their craft. Al had something internal in him the way he inhabited roles, very intense. It was a fascinating read.
http://www.newyorker.com/magazine/2014/09/15/caught-act.
I agree about lack of training in American actors but lack of manliness? I believe things are changing and that being men (or women for that matter) no longer means being one dimensional. Strange because even in Wall Street I never looked at Michael Douglas as a threatening dangerous kind of male. Maybe because I still remember him from "The Streets of San Francisco" TV show were he did play a sensitive type of cop. His FATHER on the other hand had the "menace and danger" thing down pact if you watch a number of his movies.
bettyrose says:
Susan Faludi dug up crap on him I tend to believe in Backlash. For example, he's largely the reason Fatal Attraction was changed from the original story to make the mistress crazier and the wife more passive, all in the name of making his character more manly by comparison.
I'm tellin ya says:
I agree with Lilac that Michael Douglas should steer clear of talking about 'anyone's sexuality! As a trained actor in a family of actors–he knew exactly what he was saying. He passive aggressively cast shade on his own wife! He was born on 2nd base,don't forget. And now that we're on the subject, for many years there has been speculation that his father has a bit of thee Bill Cosby behavior…
I know what you're talking about. That story has been around for years.
Meh! I love sensitive , educated, metrosexual men and can't stand macho types.
But I think the issue in the US is the lack of formal and deep acting training and also lack of appreciation for arts and theater. There aren't that many good jobs for actors outside of Hollywood.
I will forever adore this man!
familard says:
Life experience matters. Its basically green fresh-out-of-school American actors vs Brits/Aussies who have put in years working in low budget theater and TV before they come to the Los Angeles. There's a great podcast called "Another Aussie in LA", all about Aussies coming to the US.


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Someone spent a year and a half making Terminator 2 in GTA 5, and it's amazing
News May 13, 2017 Gaetano Prestia 1
grand theft auto 520
This is easily some of the most impressive GTA machinima I've ever seen. Kramer's Media on YouTube has spent a year and a half...
This is easily some of the most impressive GTA machinima I've ever seen. Kramer's Media on YouTube has spent a year and a half making James Cameron's Terminator 2: Judgement Day in GTA V, thanks to the wonders of the game's modding and in-game filming capabilities.
It almost goes scene to scene, and while at just over an hour it's about half the length of the actual film, this magical piece of machinima has all of the important scenes from the film. It's truly mindblowing.
I've seen Terminator 2 more than 20 times over the years, and I know the film back to front. This effort is just spectacular: everything from the pacing to the camera angles is spot on.
Many of the animations and assets they've used to create this are external, adding into the game manually to replicate particular scenes and movements from the movie.
You'll notice the occasional GTA character, like Jonathan "Johnny" Klebitz from The Lost And Damned.
The only downside is that the English voice over from the film is dubbed over in Russian … but I don't think that will bother diehard Terminator 2 fans. Just seeing the way some of the best scenes were recreated is mighty impressive.
Check it out below.

redpajama_set_name: RedPajamaCommonCrawl


text:
Elsmore, Bronwyn
Bronwyn Elsmore is a writer of fiction and non-fiction, and a playwright. She has a strong history of involvement in New Zealand's literary and theatrical communities. Elsmore has published over 30 short stories, numerous plays for adults and children, and poetry. She is the author of several books, including Like Them That Dream – the Maori and the Old Testament (Reed, 2000). She has received awards for her writing, and was the winner of the Franklin Writers Short Story Competition 2011.
Elsmore, Bronwyn is a writer of fiction and non-fiction, and a playwright. She was born in Wairoa, Hawkes Bay and she has a PhD from Victoria University of Wellington. For over 16 years, until 2005, she was a Senior Lecturer at Massey University, Palmerston North, and prior to this she was an education writer for the Bay of Plenty Times, and a production writer for Radio New Zealand. She has also worked as a freelance and contract writer, and a creative writing tutor.
She has a strong history of involvement in New Zealand's literary and theatrical communities. She has been a judge for New Zealand Book Awards, and has sat on a number of other judging panels for awards and competitions. She has been a client/writer with Playmarket since 1978, a member of the NZSA since 1984, and a member of The Playwrights' Association of New Zealand since 1979, as well as a number of other similar groups.
She is the author of over 30 short stories published in literary journals and magazines including the NZ Listener, and she has had over 160 articles published, as well as eight children's stories and plays broadcast on radio or television. Many of her plays have been staged in New Zealand theatres, and her staged productions include Abandon Hope, Side Show, Rushton Roulette, Celestial Pursuits, Gumboot, The Pied Piper, and Goldi-snow-errella-hood, Fallout, the Sinking of the Rainbow Warrior.
Her full list of published books includes The Cats of Dipping Dell (Golden Press, Sydney, 1979); Which Shoes to Choose? (Nelson-Price Milburn, 1989); Creedism – Religious Prejudice in NZ (Nagare, 1995); Te Kohititanga Marama – New Moon, New World: The Religion of Matenga Tamati (Reed, 1998); Mana From Heaven – a century of Maori prophets in New Zealand (Reed, 1999); Like Them That Dream – the Maori and the Old Testament (Reed, 2000); Religionz – A Guide to Religions in New Zealand (Reed, 2006); Every Five Minutes (Flaxroots, 2012); Seventeen Seas (Flaxroots, 2012); Backwards into the Future (Flaxroots, 2015) and These Islands Here – Short Stories of the South Pacific (Flaxroots, 2018).
She is editor of Will Wandafar – Writings of Bernard Teague (Nagare, 2003) and Southern Edge – New writers from Manukau Counties, Writer in Manukau Libraries (Manukau City, 2006).
She is the winner of the Keith Henderson Award for Short Story, 1976; The Phillips Cup for children's poetry, 1987; PANZ Playwriting competition for, Drought, 1992; PANZ/Minolta Playwriting competition for Celestial Pursuits, 1997; Doug Wren Award, Playwrights Association of New Zealand, 1997; PANZ/Minolta Playwriting competition for Rushton Roulette, 1999; International Writers Workshop short story competition 2003; the NZSA Short Story competition 2010; and the Franklin Writers short story competition 2011.
Bronwyn Elsmore won the adult category of the Christine Cole Catley Short Story Award 2013 for her story 'Dear Sir or Madam'.
MEDIA LINKS AND CLIPS
Bronwyn Elsmore's website
Bronwyn Elsmore's profile on the Playmarket website
Bronwyn Elsmore's NZSA profile
Read Positive Pitfalls – a New Zealand memoir
Read 'Party time on the Panama Canal', a travel article
Read 'Russia: Encounter of the best kind', a travel article


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STEREO DIVE FOUNDATION serves preview of speedy song "Chronos"
Anime, Music Video
STEREO DIVE FOUNDATION (SDF) has revealed more details of its single Chronos and at last, also dropped the preview of the title-track in the form of a short version music video. As previously described by SDF, the song "provides a rock sound with an overflowing feeling of speed!" which we definitely agree with! It really increases one's pulse with its lively drums and the distinct powerful guitar sound SDF is known for. Have a listen yourself and let us know if you agree.
https://www.youtube.com/watch?v=rXl3xqJ0YRA
Video can't be loaded because JavaScript is disabled: STEREO DIVE FOUNDATION "Chronos" MUSIC VIDEO SHORT SIZE, (https://www.youtube.com/watch?v=rXl3xqJ0YRA)
The music video takes you around landmarks in Tokyo such as Sumida, Ameya-Yokocho, Tokyo Station, Akihabara, and more, while steadily counting up using the roman numerals to bring back everything to the theme of time, which Chronos (personification of time) refers to.
The additional details which now been revealed are the artwork and the two remaining songs from the single, track Yellow, and Sprinkle.
Yellow is described as a song that will have you playing it over and over again due to its nostalgic vibes. As for Sprinkle, this is a song that takes inspiration from the anime Shokugeki no Souma: Shin no Sara where Chronos is served as the opening theme song. The anime is scheduled to start airing on October 12, but the single Chronos won't hit stores until October 23.
https://www.youtube.com/watch?v=yyHV__3tD9k
Video can't be loaded because JavaScript is disabled: 『食戟のソーマ 神ノ皿』番宣CM (https://www.youtube.com/watch?v=yyHV__3tD9k)
Don't forget that SDF has an upcoming concert planned for February 16, 2020, at Shibuya WWW. To be one of the early birds to get tickets to the show, make sure to buy the first press edition of Chronos to receive the application flyer.
Chronos (Instrumental)
Yellow (Instrumental)
Buy at CDJapan
Official Website (VERYGOO)
Official Website (Lantis)
Just a normal guy who enjoys doujin music.
Top 25 anime opening and ending songs 2019
STEREO DIVE FOUNDATION's first album is coming!
STEREO DIVE FOUNDATION's first release in 3 years "Chronos" featured in anime "Shokugeki no Souma"
Impressive line-up unveiled for anisong event "Lantis Matsuri 2019 '~ARIGATO ANISONG~'"


text:
Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease
Hiroki Tsukamoto, Petya Chernogorova, Korcan Ayata, Ulrike V. Gerlach, Ankur Rughani, Jerry W. Ritchey, Jayanthi Ganesan, Marie Follo, Robert Zeiser, Linda F. Thompson, Marco Idzko
PHA - Pharmacy
Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A2A receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5′- nucleotidase in GVHD. In allogeneic transplants, both donor and recipient CD73 were protective, with recipient CD73 playing the dominant role. CD73 deficiency led to enhanced T-cell expansion and IFN-γ and IL-6 production, and the migratory capacity of Cd73-/- T cells in vitro was increased. However, the number of regulatory T cells and expression of costimulatory molecules on antigen-presenting cells were unchanged. A2A receptor deficiency led to increased numbers of allogeneic T cells, suggesting that signaling through theA2A receptor via CD73-generated adenosine is a significant part of the mechanism by which CD73 limits the severity of GVHD. Pharmacologic blockade of CD73 also enhanced graft-versus-tumor activity. These data have clinical implications, as both the severity of GVHD and the strength of an alloimmune antitumor response could be manipulated by enhancing or blocking CD73 activity or adenosine receptor signaling depending on the clinical indication.
10.1182/blood-2011-09-375899
Dive into the research topics of 'Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease'. Together they form a unique fingerprint.
5'-Nucleotidase Medicine & Life Sciences 100%
Graft vs Host Disease Medicine & Life Sciences 79%
Adenosine Medicine & Life Sciences 74%
Adenosine Triphosphate Medicine & Life Sciences 29%
Purinergic P1 Receptors Medicine & Life Sciences 23%
Protective Chemical Compounds 20%
Allogeneic Cells Medicine & Life Sciences 20%
Tsukamoto, H., Chernogorova, P., Ayata, K., Gerlach, U. V., Rughani, A., Ritchey, J. W., Ganesan, J., Follo, M., Zeiser, R., Thompson, L. F., & Idzko, M. (2012). Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. Blood, 119(19), 4554-4564. https://doi.org/10.1182/blood-2011-09-375899
Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. / Tsukamoto, Hiroki; Chernogorova, Petya; Ayata, Korcan; Gerlach, Ulrike V.; Rughani, Ankur; Ritchey, Jerry W.; Ganesan, Jayanthi; Follo, Marie; Zeiser, Robert; Thompson, Linda F.; Idzko, Marco.
In: Blood, Vol. 119, No. 19, 10.05.2012, p. 4554-4564.
Tsukamoto, H, Chernogorova, P, Ayata, K, Gerlach, UV, Rughani, A, Ritchey, JW, Ganesan, J, Follo, M, Zeiser, R, Thompson, LF & Idzko, M 2012, 'Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease', Blood, vol. 119, no. 19, pp. 4554-4564. https://doi.org/10.1182/blood-2011-09-375899
Tsukamoto H, Chernogorova P, Ayata K, Gerlach UV, Rughani A, Ritchey JW et al. Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. Blood. 2012 May 10;119(19):4554-4564. https://doi.org/10.1182/blood-2011-09-375899
Tsukamoto, Hiroki ; Chernogorova, Petya ; Ayata, Korcan ; Gerlach, Ulrike V. ; Rughani, Ankur ; Ritchey, Jerry W. ; Ganesan, Jayanthi ; Follo, Marie ; Zeiser, Robert ; Thompson, Linda F. ; Idzko, Marco. / Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease. In: Blood. 2012 ; Vol. 119, No. 19. pp. 4554-4564.
@article{dfdee525969145bfb72fac459263a09a,
title = "Deficiency of CD73/ecto-5′-nucleotidase in mice enhances acute graft-versus-host disease",
abstract = "Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A2A receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5′- nucleotidase in GVHD. In allogeneic transplants, both donor and recipient CD73 were protective, with recipient CD73 playing the dominant role. CD73 deficiency led to enhanced T-cell expansion and IFN-γ and IL-6 production, and the migratory capacity of Cd73-/- T cells in vitro was increased. However, the number of regulatory T cells and expression of costimulatory molecules on antigen-presenting cells were unchanged. A2A receptor deficiency led to increased numbers of allogeneic T cells, suggesting that signaling through theA2A receptor via CD73-generated adenosine is a significant part of the mechanism by which CD73 limits the severity of GVHD. Pharmacologic blockade of CD73 also enhanced graft-versus-tumor activity. These data have clinical implications, as both the severity of GVHD and the strength of an alloimmune antitumor response could be manipulated by enhancing or blocking CD73 activity or adenosine receptor signaling depending on the clinical indication.",
author = "Hiroki Tsukamoto and Petya Chernogorova and Korcan Ayata and Gerlach, {Ulrike V.} and Ankur Rughani and Ritchey, {Jerry W.} and Jayanthi Ganesan and Marie Follo and Robert Zeiser and Thompson, {Linda F.} and Marco Idzko",
doi = "10.1182/blood-2011-09-375899",
journal = "Blood",
publisher = "American Society of Hematology",
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AU - Tsukamoto, Hiroki
AU - Chernogorova, Petya
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AU - Gerlach, Ulrike V.
AU - Rughani, Ankur
AU - Ritchey, Jerry W.
AU - Ganesan, Jayanthi
AU - Follo, Marie
AU - Zeiser, Robert
AU - Thompson, Linda F.
AU - Idzko, Marco
N2 - Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A2A receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5′- nucleotidase in GVHD. In allogeneic transplants, both donor and recipient CD73 were protective, with recipient CD73 playing the dominant role. CD73 deficiency led to enhanced T-cell expansion and IFN-γ and IL-6 production, and the migratory capacity of Cd73-/- T cells in vitro was increased. However, the number of regulatory T cells and expression of costimulatory molecules on antigen-presenting cells were unchanged. A2A receptor deficiency led to increased numbers of allogeneic T cells, suggesting that signaling through theA2A receptor via CD73-generated adenosine is a significant part of the mechanism by which CD73 limits the severity of GVHD. Pharmacologic blockade of CD73 also enhanced graft-versus-tumor activity. These data have clinical implications, as both the severity of GVHD and the strength of an alloimmune antitumor response could be manipulated by enhancing or blocking CD73 activity or adenosine receptor signaling depending on the clinical indication.
AB - Extracellular ATP and adenosine have immunoregulatory roles during inflammation. Elevated extracellular ATP is known to exacerbate GVHD, and the pharmacologic activation of the adenosine A2A receptor is protective. However, the role of endogenous adenosine is unknown. We used gene-targeted mice and a pharmacologic inhibitor to test the role of adenosine generated by CD73/ecto-5′- nucleotidase in GVHD. In allogeneic transplants, both donor and recipient CD73 were protective, with recipient CD73 playing the dominant role. CD73 deficiency led to enhanced T-cell expansion and IFN-γ and IL-6 production, and the migratory capacity of Cd73-/- T cells in vitro was increased. However, the number of regulatory T cells and expression of costimulatory molecules on antigen-presenting cells were unchanged. A2A receptor deficiency led to increased numbers of allogeneic T cells, suggesting that signaling through theA2A receptor via CD73-generated adenosine is a significant part of the mechanism by which CD73 limits the severity of GVHD. Pharmacologic blockade of CD73 also enhanced graft-versus-tumor activity. These data have clinical implications, as both the severity of GVHD and the strength of an alloimmune antitumor response could be manipulated by enhancing or blocking CD73 activity or adenosine receptor signaling depending on the clinical indication.
U2 - 10.1182/blood-2011-09-375899
DO - 10.1182/blood-2011-09-375899
JO - Blood
JF - Blood


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High flying North Korean general promoted to senior party role
North Korea has promoted a general long seen as a rising star in the country's powerful military and a crucial player in its missile programme, to one of the country's most powerful decision-making bodies, according to state media.
Pak Jong Chon will take up a position in the presidium of the ruling Workers' Party of Korea and will also serve as secretary of the party's Central Committee, the KCNA news agency reported on Tuesday.
In recent years, Pak has been promoted to a full four-star Army general, led the military as chief of the general staff of the army, and made prominent appearances alongside leader Kim Jong Un, including on a famous horse ride up North Korea's sacred Mt Paektu.
Analysts have attributed his rise in part to his role in developing North Korea's short-range missile programme, which has surged forward since Kim suspended long-range ballistic missile tests in 2018 amid talks with the United States.
In July, Kim accused officials of causing a "great crisis" with unspecified coronavirus lapses. North Korea has not reported any confirmed cases of the virus, nor has it elaborated on what the crises or lapses were.
Pak appears to have replaced Ri Pyong Chol, another powerful general, on the presidium, South Korea's Yonhap news agency reported.
Analysts say the reshuffle is the most significant personnel change among the core elite in years, and a probable warning from Kim that he will hold them accountable and maintain checks on their power.
Rim Kwang Il, who served as head of North Korea's military intelligence agency, was named as chief of the general staff of the army, while army general Jang Jong Nam was elected as the Minister of Social Security, KCNA said on Tuesday.
The country's Supreme People's Assembly (SPA), the isolated state's rubber-stamp parliament, will meet later this month to discuss economic policy and other issues, according to state media, as the country faces mounting economic crises.
On the agenda for the September 28 meeting are "modification and supplementation" of the national economic plan, as well as laws related to city and country development, education and recycling.
North Korea's economy suffered its biggest contraction in 23 years in 2020 as it was battered by continued UN sanctions, Covid-19 lockdown measures and bad weather.
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Home News Africa Media freedom groups seek answers over missing Tanzanian reporter
Media freedom groups seek answers over missing Tanzanian reporter
Press freedom groups have demanded answers from the Tanzanian government following contradicting statements by the country's foreign minister about the fate of a journalist who vanished two years ago.
In an interview with the BBC earlier this week, Palamagamba Kabudi, the minister, said reporter Azory Gwanda had "disappeared and died" somewhere in Rufiji, eastern Tanzania, without offering additional details.
The announcement was blasted by media watchdogs and activists who have long been calling for transparency in the case, prompting apparent backtracking by Kabudi on Thursday.
"The reference I made on Azory Gwanda contextually did not mean that Azory Gwanda is confirmed dead. To date, the government of Tanzania has no confirmation on whether Azory is dead or alive," a government statement quoted Kabudi as saying.
In a statement on Thursday, Reporters Without Borders (RSF) criticised Kabudi's "casual reference" and accused the government "of displaying a lack of consideration in its handling of the case".
"After a year and a half of silence and then downplaying the journalist's disappearance, the minister announces his death without explanation," RSF's Africa representative Arnaud Froger told AFP news agency.
"The flippancy with which the Tanzanian authorities have handled this case illustrates the low regard they have for the safe exercise of free and independent journalism."
The United States-based Committee to Protect Journalists, meanwhile, called the minister's remarks "wholly inadequate and distressing" and urged the government to immediately make public all the information it has about Gwanda's fate.
Gwanda, a reporter for the Mwananchi and The Citizen newspapers, disappeared while reportedly investigating a series of murders of police and local officials in Kibiti, in the Rufiji district of the Pwani region.
According to his wife, Gwanda disappeared on November 21, 2017, after leaving in a white Toyota Land Cruiser with unknown people on an "emergency trip".
He promised to return the following evening but was never seen again.
The government of President John Magufuli has been roundly criticized by press-freedom groups and local rights organisations for attempting to stifle media freedom in Tanzania.
The government denies the allegations.
Last year, 65 civil-society organisations wrote a letter decrying attacks against the media in the country, citing closure of media outlets, persecution and harassment of independent journalists, as well as the targeting of opposition members amongst their concerns.
Magufuli, who came to power in 2015, banned the popular Mawio newspaper in his first year, as well as two radio stations – Radio Five and Magic FM.
Tanzania ranks 118th out of 180 countries in RSF's World Press Freedom Index this year, 25 positions below its 2018 ranking.
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The Election of 1828
Posted on September 16, 2018 August 21, 2018 by Frank DeMarco
In viewing political movement, we tend to mistake cause for effect. Thermometers don't cause fevers, they reflect them. Elections usually don't determine political realignments; they reflect realignments that have already taken place. The 1828 fever-chart showed a nation in the midst of several profound transitions.
Before 1828, politics was still more or less in the hands of the class that had shaped the revolution and had guided the republic through its first half century. For all the bitter differences between New England federalists and the Virginia dynasty, they were all statesmen shaped by the confrontation with England; they were all classically educated; they were all aristocrats or their lawyers.
Before 1828, presidential nominations came by way of congressional caucus. The assumption was that elected officials were the best judges of which candidates were best qualified to become chief magistrate. Various geographical regions had their own candidates, and political insiders judged among them. The people in general acquiesced, leaving politics to their betters.
Jackson's election shook up the whole system. Partly it was his doing; partly it was Jackson being elevated by the rising tide.
As soon as Adams was inaugurated as president in 1825, Jackson resigned from his senate seat and set out with characteristic single-mindedness to replace him. Working with brilliant New York politician Martin Van Buren, he assembled a coalition that reshaped American politics. His charismatic personality and controversial policies energized a large part of the American electorate that until then had been content to leave the decision to the professionals and to the upper and middle classes who had heretofore dominated political life. Now, the common people were emotionally engaged to an unprecedented degree.
With this new engagement came partisan press attacks even more bitter than those that had harassed Washington and his successors to date. With it came a new degree of personal party loyalty. Politics assumed an importance in voters' lives that it never had before. Within a few years, selection of presidential candidates by Congressional caucus had to be replaced by selection by political conventions.
Jackson's single-minded campaign to replace Adams succeeded. He swept every region of the country except New England, New Jersey and Delaware, winning 178 electoral votes to Adams' 83. The full results of Jackson and Van Buren's alliance took a while to become obvious, but in retrospect it could be seen that it had carried the republic's politics from its 1824 state of flux into what historians call the Second Party System of Democrats and Whigs.
The Democracy held to low tariffs (for revenue purposes only, rather than protection), to silver and gold, and to the older pattern of small family farms, and expansion to provide more land to continue the old pattern. As might be imagined, the Democracy's strength centered on the frontier and in more isolated areas.
But Jackson's and Van Buren's party brought forth an opposition party, which called itself the Whig Party (in opposition to "King Andrew") led by Henry Clay. The Whigs had a program for modernizing the economy – Clay's American System – and their numbers included bankers, businessmen, and commercial farmers. Whigs flourished in the cities and, outside the cities, in market towns and commercial areas. They argued for high tariffs to foster the growth of American industry, for banks and paper money to facilitate commerce, and for public works programs to build roads, canals and railroads, to provide the infrastructure needed for rapid economic development.
(Minor parties sprang up and went away – the Anti-Masonic Party, the Liberty Party, later the Free Soil Party – but the pattern was fixed as Democrats versus Whigs until the Whigs split up and the Republican Party was born in the 1850s.)
This Second Party System endured for a quarter century, until the mounting uproar over the expansion of slavery destroyed the Whigs and brought forth the Republicans. Most Whig policies became Republican policies, just as many prominent Republicans, such as William Seward and Abraham Lincoln, were former Whigs. The changing times favored their vision of the nation's future.
The Democracy had a brief period of dominance, peaking in the presidency of James Polk, but in retrospect it can be seen that they were trying to hold back the tide. We were not going to be a nation of small towns and small farms. The Democracy went into a decline that lasted, with brief and almost accidental interruptions (the presidencies of Cleveland and Wilson) until the Great Depression reshaped politics once again. The Democrats had hitched their wagon to the wrong star.
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The vocal cords are situated in the larynx (voice box), and they vibrate together in order to create sound or speech. Lesions that occur on the vocal cord can be either benign or malignant (cancerous).
The most common benign vocal cord lesions are vocal cord cysts, polyps, nodules, and contact ulcers. A vocal cyst is a firm fluid collection that occurs inside the vocal cord. It is usually the response to injury or vocal abuse. After repetitive misuse, fluid within the vocal cord walls itself off and forms a cyst. The size of the cyst will affect the degree of disruption to normal vocal cord vibration and associated hoarseness.
Diagnosis Causes Symptoms Treatment
An endoscopy of the larynx is a minimally invasive diagnostic procedure performed using a local, topical anesthetic during your office visit. During the procedure, a thin, flexible camera, known as an endoscope, is passed through the nostril to provide a detailed view of the nasal passages, sinuses and larynx. This allows for a complete evaluation of these structures, the results of which can be digitally recorded and reviewed with the patient immediately after the procedure.
If a mass or lesion is found in your throat or on your vocal cords, we can schedule to take a biopsy and remove the lesion for you in an expeditious and personalized manner for rapid diagnosis and resolution of the problem.
The cause of benign vocal cord lesions is thought to be due to voice overuse. This may mean excessive:
Shouting
Singing with improper technique
Violently coughing during a prolonged respiratory infection
Symptoms of vocal cord lesions:
Breathiness
Loss of vocal range
Vocal fatigue
Treatment for vocal cord lesions:
Singing voice therapy
Voice rest
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