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Milt's File
A file of links relating to Extension 720 with Milt Rosenberg, a talk show on Chicago's WGN Radio.
Tonight on Extension 720 after a Cubs game, we play some recently recorded interviews. More information on this and other programs is available here. You can listen to the program from 9:40 (approximately) to 11 p.m. central time here.
posted by Milton @ 2:32 PM
THE RICE ROUNDUP: The Christian Science Monitor has put together a link-heavy review of press and public reaction to Rice's testimony yesterday. This "great confrontation" will rapidly recede from memory--but while you are thinking about it, this review should more than fill your requirements.
YEAH--BUT DID HE LIKE THE BOOK? Robert Sam Anson's review, in the NY Observer, of the Clarke book reveals that it has been misclassified. It belongs in the fiction section, next to Ludlum (OK) or Proust(??). Anyway, That's Entertainment!!
HANSON ON THIS WARTIME THAT TRIES MEN'S SOULS: We don't know any commentator on the proper and principled use of American military power who sees things with greater clarity than does Victor Davis Hanson. That's why we have him on our radio program rather frequently---and that's why we commend this article from the National Review to your attention.
WHAT (AND HOW) DO THEY (ISLAM) REALLY THINK ABOUT US? A strong thesis reflecting civilization incompatibility is advanced in this op-ed that appeared a few days ago in the Wall Street Journal.
THE KERRY/GORE DIFFERENCE ON FREE TRADE AND THE WAR AGAINST POVERTY: Once again, Krauthammer cuts through the disingenuous of present political rhetoric--and gets to the compelling truths that the campaigning Democrats once knew and now obscure.
THE "RACIALLY VICTIMIZED" COLLEGE PROFESSOR: Michelle Malkin provides the follow-up to the story of Kerri Dunn whom she ranks with Tawana Brawley. Interesting comparison--but, there is no Sharpton-like demagogue/mountebank to capitalize on the fraud.
MEMORIES AND (SEVERE) JUDGEMENT OF ALFRED KAZIN....from Hilton Kramer, the Editor of New Criterion. The resonating sound of friendships crashing is still heard in the reminiscences of the New York Intellectuals...as in this inevitably fascinating piece occasioned by the recent publication of Kazin's America.
WHAT BLOGS ARE DOING (AND WILL DO) TO JOURNALISM: The former editor of Digital Media gets off some strong predictions in this interview from Editor and Publisher.
WHAT PRICE RADIO DECENCY? The Reuters correspondent seems to think that dumping or curbing the likes of Stern will be bad for business. Hmmmm. Might one suggest that some things are, perhaps, more important than a few percentage points of profit? Naahh!
NEW FRONTIERS OF CARTOGRAPHY: Great new maps are being drawn--not of mere geography but of intellectual territory. Here, from the National Science Foundation, is an introduction to new material that should be of interest and utility to any working scientist and/or to any student of the sciences.
A GREAT ADVANCE IN SEARCH-ENGINE TECHNOLOGY....particularly for long-lost or recently-misplaced esprits. But, do always remember to consider the source of the good tidings that seem to brighten you life.
GOSPEL TOUCHED BY NASHVILLE: This fine collection features, among others, Patsy Cline, Red Foley, Kat Starr and Tennessee Ernie Ford. Not to be missed: Hank Williams' I Saw the Light.
Tonight on Extension 720, we explore the world of branding (in the marketing sense) and examine some branding successes and failures. More information on this and other programs is available here. You can listen to the program from 9 to 11 p.m. central time here.
THE IRAQI UPRISING...SO FAR: This report from the NY Times this morning can only serve as an "update" since the game is still afoot. But the call for an end to violence from Grand Ayatollah Ali al-Sistani does make clear that al-Sadr is leading a breakaway Shiite movement.
GETTING TO KNOW MOQTADA: This useful primer on the stirrer-up of the week was provided by the Washington Post yesterday. For a more general account of Shiite history and credo, see the next item.
MORE THAN ALL YOU WANT TO KNOW ABOUT THE SHIA: This semi-official site can be explored for a year. A good and informative beginning is the section on Fundamentals of Islam.
AND MORE ON MOQTADA: The iraqo-cognoscenti have had their eyes on al-Sadr for a few years. This informative article from the Christian Science Monitor last October places him in the context of religious and political competition.
HE MAY BE RIGHT...UNFORTUNATELY: In this Newsweek piece Richard Wolffe argues that Iraq may tip the November presidential election. The adversarial tone of this morning's hearings at the 9/11 Commission and, more particularly, the Rice-Kerrey confrontation, suggest that it may well play out as he worriedly predicts.
IF DEMOGRAPHY IS THE ULTIMATE TRUTH....the decline and ultimate disappearance of European Christendom is probably predictable. And what will rise in it's place? Islamo-Europe! So says this challenging article by Niall Ferguson from last Sunday's NY Times Magazine.
OF THE FAKING OF "HATE CRIMES" THERE IS NO END! The latest one to be reported--or so the cops are saying--was done by a Professor of Psychology at a prestigious college in California. Go know!!
THE UNEXPECTED CONSEQUENCES OF "AFFIRMATIVE ACTION".....in India, Malaysia, Sri Lanka, Nigeria and the United States are examined in a new book by Tom Sowell. This cogent review from the current issue of Commentary raises the question (as, obviously, does the book) of whether the refusal to perceive "on-average" differences between social groups works against the real interests of their members.
THE STRANGE STATE OF HIGHER EDUCATION....in the strange state of California. This is election material put out for a candidate seeking to be returned to the state senate--but, if the facts are as he says, they are crazier (or even more politically beholden to the hispanic sector of the electorate) than we ever suspected.
THE LANGUAGES OF THE PASSION OF THE CHRIST....Apparently, Gibson and his advisors got their Aramaic wrong and, furthermore, the Roman soldiers did not speak Latin! This note by a scholar in ancient middle-eastern languages is from an e-mail bulletin issued by the Martin Marty Center at the University of Chicago Divinity School.
THE PAGLIA IS HEARD IN THE LAND ONCE AGAIN....and here she notes and complains that the contemporary young "have become unmoored from the mother ship of culture." The further explication of this aggrieved judgment leads her, in this surprising but well-aimed article from Arion, to--of all things--Byzantine icons and Aztec skulls.
DOCTOR DALRYMPLE'S ENCOUNTERS WITH BURGLARS AND PROSTITUTES......in literature and in "real life." T.D. is one of our favorite modern essayists and has been a welcome guest on our program. This latest piece has just appeared in the New Criterion.
MORE GREAT CHAMBER MUSIC FROM THE ARGERICH FESTIVAL IN LUGANO: All beautifully performed, but the outstanding item is the Beethoven Trio for Clarinet, Cello and Piano.
Tonight on Extension 720 after a Cubs game, we talk to military and foreign policy experts to discuss the latest developments in Iraq. More information on this and other programs is available here. You can listen to the program from 9:25 (approximately) to 11 p.m. central time here.
THE LATEST WAR REPORT AS WE GO TO PRESS...is from Channel News Asia (based in Singapore) and suggests that "Vigilant Resolve" will, indeed, require a lot of resolve.
THE "SHIA REVOLT" IN HISTORICAL PERSPECTIVE: This article from BBC adds a bit of clarity to the nature of the Sadr/Sistani split..and thus to the motivation for the current uprising.
AN IRAQI GAME PLAN THAT "CONFRONTS THE QUAKING QUAGMIRISTS:" This realistic--and heartening--appraisal of the situation comes from the almost-always level-headed Bill Safire of the NY Times.
A MESSAGE TO GEORGE AND JOHN: TUNE IN TO CALVIN! The Executive Editor of the Pittsburgh Post-Gazette directs the candidates' attention to the wisdom of the taciturn president of the twenties.
THERE ARE (AND WILL BE) MORE JOBS....but can American education and parental responsibility rise to produce young people capable of filling those jobs? The data are reviewed and the questions strongly stated in this op-ed from today's Seattle Times.
ALGER HISS WAS GUILTY--UTTERLY AND COMPLETELY....but the myth of his innocence still persists. Why? And how was it fabricated and maintained? These questions are persuasively answered in this fine review, from Commentary, of the newest in the long line of studies of the case.
WHAT IS A "LAST-GO-TRADE?" And how is it connected to an "Alaskan trade?" This is one of the many oddities of American speech as clarified in the latest volume of the Dictionary of American Regional English. Something of the story and achievement of the DARE is recounted here in this illuminating article from the magazine of the National Endowment for the Humanities.
CHESS, PLATO, ARTIFICIAL INTELLIGENCE AND THE COSMOS: Yes, this is an essay that makes the big try--but, at the same time, is unforced, entertaining and provocative of serious thought...in fact, a good example of what, at its best, is sometimes to be found at Jim Glassman's Tech Station.
GOOGLE IS NOT THE ONLY GAME IN TOWN....and may not be the best. Some wisdom in search of the best searcher and based on empirical investigation is summarized here in an article from First Monday magazine.
WHAT DOES TV DO TO KIDS' BRAINS? Perhaps nothing...but there is increasing research-based evidence that some "rewiring" may be the main effect of sustained TV watching during the early years. Here's some reliable--rather than sensational--coverage from today's Boston Globe.
SIR ISAIAH BERLIN LOOKS AT THE "GREATS" OF SOVIET CULTURE: A new collection of his essays on people like Akhmatova, Pasternak and Shcherbakov has recently appeared and is here reviewed for the Moscow Times by the redoubtable Walter Laqueur.
POLITICIANS HAVE ALWAYS BEEN PECULIAR PERSONS....as Aristophanes established at a high level of risibility a long time ago. Sometimes scholarly articles are more fun (and closer to truth) than feverish journalism...as witness this fine essay on the treatment in classic Greek comedy of men of public prominence. The author is a Canadian professor and his article was published a few years ago in Classics Ireland.
DINNER AT THE RITZ.....even for vegetarians? This wonderfully artless (but not clueless) profile of the restaurant of the Ritz Hotel in London should be kept on file for whenever they are all booked up at Simpsons on the Strand.
MOZART'S FOURTEENTH PIANO CONCERTO....is performed here not with full orchestra but with a chamber group. The result is a shimmering reading that discloses the "deep structure" of the composition.
Tonight on Extension 720, we welcome representatives from Chicago's own AFTRA/SAG Radio Players, who will perform excerpts from old time radio programs. More information on this and other programs is available here. You can listen to the program from 9 to 11 p.m. central time here.
THE NEW OPPOSITION IN IRAQ. Considering the source, this BBC report is not grossly anti-American and it does provide some useful information about the "militia" now shooting at our guys on the streets of Baghdad and Fallujah. Do also check out the linked profile of Moqtada al Sadr.
WHAT, REALLY, HAS GONE WRONG IN IRAQ? There are many views out there in the op-ed-osphere today. This one by John O'Sullivan, in today's Chicago Sun-Times, seems to us to be as accurate a diagnosis as is now available.
A TOUR OF THE IRAQI HORIZON. This is the sort of thing The Economist of London does quite well--a quick but sophisticated review of the problems, the players, the strategies and the possible outcomes and, always, tempered by the sense that human society is and will remain radically imperfectible.
THE WISE DENTIST OF BAGHDAD. Here's the latest blog from Zayed who excels in giving better "on the ground" reports than most of the conventional journalists. Who exactly is Moqtada al Sadir and who (and how many) are his followers? Read on...
ANOTHER BAGHDADI BLOGS...and gives a differently nuanced picture of the current "uprising" in Baghdad. We know less about this unofficial reporter than about Zayed...but she, too, is young, sharp-eyed and obviously has some experience of the West.
ARE PURGE-TRIAL CONFESSIONS COMING BACK? This report from Moscow--and published in the Moscow Times--carries the scary implication (or reasoned inference) that the Putin bunch have not forgotten their KGB methods--and that some may still secretly enetertain some reverence for Stalin--or at least for his way of handling "opposition."
THE EXECUTIONERS' TALES. A Romanian newspaper has recently published an account of the execution of the Ceaucescus. What stands out is the haplessness of the three soldiers who did the shooting. One does wonder why, so many years after the fact, this is still given coverage in a national newspaper. Is someone still working off some guilt or remorse?
ON THE DECONSTRUCTION OF AMERICAN SOCIAL SOLIDARITY. Samuel Huntington of Harvard is worried about how our national identity may be growing more ambiguous and less unifying. And if that is happening (or might begin to happen) says he in this strongly-stated essay from the new issue of The National Interest, here's how and why.
THE UNRULY AMERICAN SCHOLAR. When Anne Fadiman replaced our friend Joe Epstein as editor we were "shocked, do you hear?" Now she has been rather unceremoniously dumped as well. What's going on? The Chronicle of Higher Education gathers the pieces together in this story.
THE CHAIRMAN OF THE NATIONAL ENDOWMENT FOR THE HUMANITIES...likes Italian cooking! Actually, he and the "Italian" chef in this dialogue do have some quite interesting ideas about the connections between cuisine and culture.
WE ONCE FROLICKED THERE...that is, on Times Square where a high school student could see a French classic film at the Apollo for just two dollars--and get a good hot dog for fifty cents in the seedy place next door. A new book recounts how everything has changed and this nostalgic review in the New Yorker adds some evocative further detail.
WHAT TO DO WHEN THE STAR DIES BEFORE THE RELEASE (OR COMPLETION!) OF THE FILM. This truly informative article from USA Today Magazine tells the story behind many srories of post-mortem crisis.
BECHET AT HIS BEST. The jazzmaster of the soprano saxophone is heard here in some perfect and distinctively punctuated performances in which he is backed by the band of Noble Sissle.
WHEN THE SOUND OF WAR BLASTS IN OUR EARS. As we "go to press" this is the latest story from Baghdad as reported in the Financial Times of London.
posted by Milton @ 12:17 PM
AND HOW ABOUT BEEFING UP THE TROOP LEVELS? Both Senators Lugar and Biden agree that the "handover" in Iraq will have to be delayed. Right! But what do we do to defuse the rebellion that is now killing Americans in ever- escalating numbers? We will be asking that of some true "experts" Wednesday night on Extension 720.
THE RWANDAN GENOCIDE BEGAN TEN YEARS AGO. Has anything been learned about how to prevent the recurrent (through all history) lapses into sytematic state murder? Two ranking people at the Brookings Institution have some useful (if not particularly optimistic) things to say in this article from Yale Global Online.
THE WAR-FOSTERED EMERGENCE OF THE BLOGOSPHERE. There are now hundreds of blogs up in the sphere that originate from Iraq, Iran and from members of our military. How and why this has happened and what consequences will follow in the reshaping of journalism are examined in this well-informed account from the new issue of The National Interest.
INSOURCING EXCEEDS OUTSOURCING...by a considerable degree of magnitude. Has anyone yet conveyed this news to the Kerry campaign or--for that matter--to Ms. Garafalo? This interesting bulletin of some corrective value came from Bloomberg News over the weekend but has not yet been noted at campaign central.
WE STILL LOVE YOU, CHAIRMAN MAO! From Xinhua, the official Chinese news agency comes this charming collection of panegyrics for the man who presided over the "state killing" of some 70-80 million Chinese. Is China ready for democracy? For press freedom? For serious political education? Or should their government and press perhaps be turned over to Taiwan?
THIS IS HOW THE WORLD BEGINS...according to the latest quantum theoretic thinking. This great article from American Scientist creates the sense--or at least the illusion--that one understands how EVERYTHING followed from a random quantum fluctuation.
IF WE REALLY TOOK COLLEGE TEACHING SERIOUSLY...here's how we would go about it. As a veteran academic, the proprietor welcomes--and strongly endorses--these wise, and quite practical, comments by the former provost of the Graduate Center of the City University of New York.
FRAUD, SCAM AND MURDER IN THE RARE BOOK TRADE. It isn't all bemused bookmen in somewhat crumpled tweeds trading notes on errata in the first edition of Johnson's Rasselas. This startling examination of the underside of the antiquarian books world appeared recently in Maisonneuve magazine.
AN AUSTRALIAN DECODES AMERICAN FOOD VOCABULARY...and gets it all wrong which is, of course, the point of the gag. Actually, we too have wondered why they are called "Clark Bars."
ANOTHER GREAT CONCERT FROM LUGANO. From the Argerich Festival in June of 2002 wonderful performances of concertos for two, two and four pianos by, respectively, Mendelssohn, Mozart and Bach.
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A Tale of Two S&P 500s
As a new trading day gets underway, the S&P 500 rests a mere seven points below its all-time high: Last Friday, the index closed at a record 2,439.
But is that a reflection of a healthy market overall? Or a mere handful of stocks propping up everything else?
That's a crucial question — because as we said a few weeks ago, most late-stage bull markets share a common trait: The major stock averages look strong only because a few stocks are going bonkers while the vast majority are going nowhere or going down.
That's how it went during the late stages of the dot-com bubble: Microsoft, Intel, Dell and Cisco soaring higher, the rest of the market just plodding along. The S&P 500 peaked above 1,500 in early 2000. By late 2002, it was below 800 — a brutal drop of nearly 50%.
Which brings us to the concept of "the S&P 495."
Last Friday we mentioned how Facebook has rocketed from a $100 million company at the time it went public five years ago… to No. 5 on the list of the most valuable publicly traded companies in the world. The only companies ahead of it on the list are Amazon, Microsoft, Alphabet (Google) and Apple.
"Since 2014," writes Owen Williams of the research firm Williams Market Analytics, "the craze for these five tech/internet companies has increased crescendo to the point that the Big 5 have eclipsed the entire S&P 500."
Mr. Williams illustrated the phenomenon last month with a chart showing the performance of the Big 5 relative to the other 495 stocks in the S&P 500… going back more than four years.
"This is just nuts," Williams writes. "Since mid-2013, the S&P 495 has eked out a meager +6.1% gain per annum. The Big 5's stocks have appreciated at a whopping +57.3% per annum over the same period."
And so it goes this year: The S&P 495 is up about 4%. The Big 5 are up nearly 25%.
Mr. Williams' inescapable conclusion: "This market has become a one-trick pony. It has sure been a good trick… as long as it lasts. But the lack of broad market participation concerns us. A market rally built on the performance of just five stocks is undeniably fragile."
No, this doesn't mean we're in for an imminent rerun of the dot-com crash. But we know a pivot point is approaching… and it pays to adopt a new strategy.
Which is why we can't stop thinking about our newest contributor's prescient call about Facebook 10 years ago. As we mentioned on Friday, James Altucher was nearly laughed off CNBC one day in July 2007 when he ventured that Facebook would one day be a publicly traded $100 billion company.
At that time, it was barely three years after Mark Zuckerberg launched "Thefacebook" from his Harvard dorm room. It was already privately valued around $1 billion. But to grow 100-fold from there? Impossible, scoffed the other CNBC talking heads.
The rest is history: When FB went public in May 2012, it was a $100 billion company.
With his hedge fund and private-equity background, James knew exactly what to do when he made that prognostication in 2007: He invested via the back door.
Facebook? Uh-uh.
"I invested in every marketing company I could find that was working on products related to Facebook marketing," he says. "I made a killing.
"There are 8,000-plus public companies out there in the public markets," James explains. Newspapers like The Wall Street Journal maybe focus on 10 of those companies. We're talking the giants like Apple, Google, Tesla, etc.
"But those aren't where the big money is being made.
"It's all about the other 8,000 companies. The backdoor plays."
Now recall the context in which James made that Facebook forecast, and his subsequent "backdoor" investments.
It was July 25, 2007. The earliest tremors of the housing/credit earthquake were already reverberating through the markets. Only nine days later, Jim Cramer had a meltdown on CNBC, tearfully begging Federal Reserve Chairman Ben Bernanke to "stop acting like an academic and do something!" The S&P 500 reached its peak in October… and took a sickening 57% plunge over the next 17 months.
But there was James, plowing his money into "backdoor" plays on Facebook… and making a "killing."
That's right… Backdoor investing can help you survive and even thrive during a vicious market downturn — like the one the "S&P 495" phenomenon is foreshadowing.
In less than 24 hours, James will host an exclusive event for Agora Financial readers, revealing the secrets of "the 1,000% backdoor play." Play it right, and he says you could make 10 times your money before the end of this year.
This online briefing is tomorrow at 1:00 p.m. EDT. If you have a lunch appointment, we urge you to reschedule. If you have work obligations, get them out of the way early. This is an event for which James ordinarily charges $525… but because he's joining forces with us, we're making it available FREE. All we ask is that you sign up in advance at this link.
As noted before, stocks are little moved today… and so it goes with most other asset classes. With one notable exception.
Crude is down more than 4%. The Energy Department delivered its weekly oil inventory report this morning. It showed a surprise 3.3 million barrel increase in U.S. crude stockpiles.
At last check, a barrel of West Texas Intermediate is a few pennies over $46.
That's a 10% drop in barely two weeks. Jim Rickards' forecast in this space last week of a drop toward $40 is unfolding even faster than we were anticipating…
Which isn't necessarily a bad thing for U.S. oil producers.
As Jim explained last week, many deep-pocketed investors were able to buy drilling rights and equipment at fire-sale prices during the worst of the shakeout in the U.S. shale patch last year.
Between that and the fact that U.S. producers are becoming ever more efficient at squeezing oil out of shale rock… these U.S. shale plays can be profitable even if crude tumbles below $40.
And all this at a time when OPEC just extended their production cuts for another nine months: "With OPEC pumping less crude oil," says our income specialist Zach Scheidt, "the door is open for U.S. drillers to increase production and take market share away from OPEC. And that's exactly what is happening."
But at this time, Zach says the real beneficiaries of this trend will be the companies moving this oil from place to place. "The more crude oil is produced in the U.S., the more profit pipeline companies who transport this oil will generate."
Zach suggested a way to play it this week in his premium advisory Income on Demand. If you haven't tried his "perpetual income strategy" yet, you need to see how easy it can be.
We're now one day out from former FBI chief James Comey's testimony to Congress… and one week out from another Federal Reserve interest rate increase. Neither bodes well for the stock market, says Jim Rickards.
"Much of the stock rally this year, " he says, "is in anticipation of Trump policies on tax cuts, fiscal stimulus, infrastructure spending, health care reform and deregulation. Unfortunately, almost none of the Trump agenda has come to pass, and much of it may never see the light of day.
"There is no consensus in the Congress on health care or taxes. There is no money to pay for tax cuts or infrastructure spending. Meanwhile, Congress wastes time on debt ceiling debates and irreconcilable fights over spending priorities such as Planned Parenthood, the Wall and sanctuary cities that will probably lead to a government shutdown by October. Throw in the Russia investigations and a fight over a new FBI director and you can see why nothing will get done."
Meanwhile, "Janet Yellen and the Fed are throwing a double dose of cold water on Trump's plans," Jim goes on.
"The Fed will definitely raise interest rates next Wednesday and indicate plans for at least one more rate hike, maybe two, later this year that markets will have to factor in. In addition, next Wednesday the Fed will provide more explicit guidance about plans to reduce the money supply in order to normalize its balance sheet. This quantitative tightening, 'QT,' is the opposite of QE and will have the same effect as raising interest rates even further.
"With this Fed double dose of tightening into weakness, and Trump's policies dead on arrival, we're set up for a recession and stock market crash by this summer."
"Gentlemen, your silence is deafening!" says an email from a reader. (We'll spare you the ALL CAPS in which it was written.)
"Has no one read Ted Butler's article on silver manipulation? Where are Jim Rickards and the rest of the gold and silver bugs who should be interested in such happenings? Let's hear from you!!!"
The 5: We addressed this question with Jim Rickards' help less than three weeks ago.
Manipulation of the precious metals market is real… but we feel genuinely sorry for the crowd of everyday investors who find meaning in their lives by identifying every anomaly in the weekly Commitments of Traders reports, convinced this time they've found the smoking gun that will send precious metals prices skyrocketing and send a bunch of banksters to jail.
Sorry, that's not how we're going to get to $10,000-an-ounce gold.
A search of The 5's voluminous archives reveals it's been six months since we ran the following quotation from the inimitable Marc Faber (who tipped us off to the "S&P 495" research spotlighted here today). We turned it into a meme. It's as valid now as when Faber said it seven years ago…
Oh, but we're not done with the reader accusations we're suppressing the truth!
James Altucher's remarks this week about Bitcoin ("I think Bitcoin has about a 1 in 100 chance of being a survivor") prompted the following outburst: "Why do you folks continue shooting yourself in the foot with TOTALLY bogus info?
"Please come clean about why you so vociferously keep bashing Bitcoin, all the while it is rising like gangbusters.
"Your information is promoted as being Very Accurate, and now is becoming nothing more than another mouthpiece of the Mainstream Media Propaganda Fake News."
The 5: *Sigh*
We're guessing the reader took exception to the Bitcoin remarks of our Ray Blanco and Matt Insley in a couple of other Agora Financial publications last month… and now he's spoiling for a fight, misinterpreting James' remarks.
Note that James said it's unlikely Bitcoin will be "a survivor" among the many cryptocurrencies out there. That doesn't mean its price can't leap another four or five times higher in the meantime.
But is that because of Bitcoin's unique advantages? Or is it, as DoubleLine Capital's Jeffrey Gundlach recently averred, a function of hot money from China looking for anything it perceives as safe? He says it's no coincidence Bitcoin has doubled at the same time the Shanghai Composite Index has corrected 10%.
Gee, guess all the good condos in Vancouver are taken now. Bitcoin's all that's left…
Now for the final installment of James Altucher's "ultimate cheat sheet" for investing all your money.
We pick it up with the letter "P" and the concept of investing in yourself. One last time, James' obligatory disclaimer: "Don't follow any of my advice. This is advice that I do and follow and it works for me."
The Ultimate Cheat Sheet for Investing All of Your Money — Part 5
P) What does that mean, "invest in myself?"
It costs almost nothing to start a business. Find something people want and start posting information about it on a blog and then upsell your services on the blog.Or write 1000 small books about different topics and publish them on Amazon. You can do this on the side while you learn and have a full time job and then when you are ready, you can jump to your other passive streams of income. I have a podcast coming up soon with a guy who makes $25,000 a month doing this. Note: It takes a lot of work to find "passive" income but when it happens, it's worth it. These are some ideas. There are many others.
Invest in experiences rather than possessions. Figure out interesting and unique experiences you can have or places you can go to (but they don't always have to be places). Experiences pay much higher dividends than an extra TV or a nicer car.
Books. Reading is the best return on investment. You have to live your entire life in order to know one life.But with reading you can know 1000s of people's lives for almost no cost. What a great return!
Q) Should I save money with each paycheck?
No. Just try to make more money. That is easier than saving money. I find that whenever I try to save money I end up spending more. I don't know why that is. I'm a horrible spender, which is probably why I've gone broke so many times.
Better to just make more with many streams of income so you don't have to worry about going broke. And then saving will come naturally as you make more money.
Don't forget that a salary will never make you money. After taxes and the daily grind, and your exhaustion and the feelings of "I hate my job," and then inflation and then new expenses (kids), you will never be able to save. Avoiding Starbucks every day won't make you a millionaire, that's a fact.
I say it glibly, "try to make more money." I know it's not that easy. But in the long run, if you have a constant focus on alternative ways to make more money, then you will.
R) What else should I do with my money?
Forget about it.
Money is just a side effect of health.
I talk a lot about the daily practice I started doing when I was at my lowest point.
I know now after years of doing it that it has worked. I've done very well with it, and I started doing it when I was dead broke, lonely, angry, depressed, and suicidal.
I didn't start it from a position of privilege.
Here's the whole thing: stay physically healthy in whatever way you know how (sleep well, eat well, exercise). Be around good people who love you and respect you and who you love and respect, and be grateful every day.
Think of new things each day (or all day) to be grateful for. "Gratitude" is another word for "Abundance" because the things you are most grateful for, become abundant in your life.
And finally, write down 10-20 bad ideas a day. Or good ideas. It doesn't matter. After exercising my idea muscle for six months, I felt like an idea machine. It was like a super power that just wouldn't stop. More on this in another post.
Money and abundance in your life is a natural side effect of the above. I know this for myself but now since writing about it for almost four years I can tell you from the letters I get that it works for others.
S) What's in it for you?
I don't know. I used to write about money stuff because I wanted investors in my hedge fund, or I wanted to sell books, or get speaking engagements. Now I want none of that.
I hate writing about finance now. Because it's almost all bull**** and I don't want to be like the other BS.
But I get worried that in a world of increasing economic uncertainty that more and more people are getting "stuck" and getting lied to and are scared about what is happening.
Most people will think I am giving bad advice. That's fine. I just am trying to avoid the BS and I hope you do also.
Too many people I know are nervous and depressed.
There's nothing else to know about investing your money. If your bank tries to give you any advice just say, "thanks but I'm OK."
If they want you to put your money in a savings account, even "so you can get the interest" I would politely decline. There's a reason they are asking you to do this and I have no idea what it is but it's not good for you.
You won't get rich investing your money but you can do very well. And if you combine that with investing in yourself, you will get wealthy.
But only if you remember that financial wealth is a side effect of real inner wealth.
This is the most powerful investment you can do with your time and your life.
You can always make money back when you've lost it.
But one single split moment of stress and anxiety you will never make back again.
Investing in the future will never bring back the past.
To be able to sit and not have a million stressful thoughts racing through your head. To be able to appreciate everything around you for the abundance it is.
Most people think they need to say "thank you" to the world.
But the world is constantly saying "thank you" to you for being alive, for creating new things, new energies, new experiences.
Every day give the world at least one more reason to whisper "thank you" to you.
If you can hear that whisper, everything else, every gift in life, becomes expected. You earned it.
Just take it.
For The 5 Min. Forecast
Ed. note: Much as James dislikes writing about finance, he is eager to tell everyday readers like you how to invest via "the 1,000% back door."
Using this strategy — he's used it in his own portfolio — James says it's entirely possible to make 10 times your money between now and the time the calendar flips to 2018. That's less than seven months.
Tomorrow at 1:00 p.m. EDT James takes the wraps off this strategy during a live online event exclusively for Agora Financial readers like you. The cost of entry is FREE… but we do ask that you RSVP so we know how many people to expect and our servers won't crash. Here's the signup page.

redpajama_set_name: RedPajamaCommonCrawl


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E3 2009: New Super Mario Bros. Wii details and screens
Marc Normandin
We promised more details, and now we have them for you, along with some artwork and screenshots. The new Super Mario Bros. Wii is a four-player side-scrolling platformer with a balance of co-op and competitive elements to it. You can choose to save your friend from danger by picking him up, or toss him into a pit of spikes or an incoming fireball. Why? Because it's hilarious, that's why.
Mario and Luigi are both playable characters, as are two Toad characters. Nintendo promises that many of our other favorites from the Mushroom Kingdom will make appearances in the game, which makes me wonder if any of them are secret playable characters, or if Nintendo is just keeping a lid on who is playable besides the Bros. and Toads for now.
The game will have some motion control, and it can be used for both co-op and competitive purposes. For example, you have seesaws in the game that can be used to get to hard to reach areas on the screen; if you're the first character on it, you can either help your friend out, or be a jerk and mess with the incline to stall your friend. This is also important, because the game tallies your score at the end of each level to see which one of you is the highest scorer.
The game has sold me on the concept of competitive multiplayer, as well as Penguin Mario. He turns into a freakin' penguin! That's the most adorable thing I've seen since… well, Bee Mario.
e3E3 2009New Super Mario Bros. Wiinintendovideo gamesWii
Marc Normandin was gaming editor of Blast from 2008 to mid-2010. You can reach him via e-mail at marcnormandin@gmail.com, or follow him on Twitter @Marc_Normandin


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Walt Disney Pictures Launched New Trailer of "TANGLED"
Walt Disney Pictures has just released the latest trailer of the 3D animated feature Tangled, which is billed as one of the most hilarious, hair-raising tales ever told! In the film, when the kingdom's most wanted—and most charming—bandit Flynn Rider (voice of Zachary Levi) hides out in a mysterious tower, he's taken hostage by Rapunzel (voice of Mandy Moore), a beautiful and feisty tower-bound teen with 70 feet of magical, golden hair.
Flynn's curious captor, who's looking for her ticket out of the tower where she's been locked away for years, strikes a deal with the handsome thief and the unlikely duo sets off on an action-packed escapade, complete with a super-cop horse, an over-protective chameleon and a gruff gang of pub thugs.
In Philippine theaters soon in Disney Digital 3D™ and regular format, Tangled is a story of adventure, heart, humor and hair—lots of hair.
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Join the movement,
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We envision a world where excellence and the best service are synonymous with government and advanced by leaders, community members, and residents. Help transform local government by bringing the best public innovation tools and research to cities around the world.
Join our movement,
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The Bloomberg Center for Public Innovation (BCPI) at Johns Hopkins University seeks a seasoned Executive Assistant to provide expert administrative support to the Executive Director and members of her executive team, and to manage the Executive Director's schedule and...
Research Data Analyst
Johns Hopkins University (Bloomberg Center for Public Innovation) seeks a Research Data Analyst to join the Communications Practice. The first of its kind in the world, the Center aims to advance the field of public sector innovation by marrying cutting-edge practice...
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As part of its expanding team, the Bloomberg Center for Public Innovation at Johns Hopkins University (the Center) is seeking an experienced Program Administrator of Student Engagement who will support the management of the Center's growing student engagement...
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Johns Hopkins University seeks a Communications Associate for the News & Content Unit of the Bloomberg Center for Public Innovation (the Center). The Center is quickly becoming a globally recognized organization focused on advancing the art and science of public sector innovation, especially among local governments. The Center works to increase awareness of the impact of local government innovation with a special emphasis on the ways in which residents contribute to the design, development, and delivery of new services and policy approaches.
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Heather Booth
American Civil Rights Activist, Feminist & Political Strategist
Heather Booth is an American civil rights activist, feminist, and political strategist who has been frequently cited for her effective activism in progressive causes. During her student years, she was committed to both the civil rights movement and feminist causes. Since then she has devoted her career to feminism, community organization, and progressive politics.
She has been an organizer starting in the civil rights, anti-Vietnam war and women's movements of the 1960s and continuing through today. She created JANE, an underground abortion service started before Roe.
Booth was the founding Director and is now President of the Midwest Academy, training social change leaders and organizers. She has been involved in and managed political campaigns and was the Training Director of the Democratic National Committee. In 2000, she was the Director of the NAACP National Voter Fund, which helped to increase African American election turnout by nearly 2 million voters. She was the lead consultant, directing the founding of the Campaign for Comprehensive Immigration Reform in 2005.
In 2008, Booth was the director of the Health Care Campaign for the AFL-CIO. In 2009, she directed the campaign passing President Obama's first budget. In 2010 she was the founding director of Americans for Financial Reform, fighting to regulate the financial industry. She was the national coordinator for the coalition around marriage equality and the 2013 Supreme Court decision. She was strategic advisor to the Alliance for Citizenship (the largest coalition of the immigration reform campaign). She was Field Director for Americans for Tax Fairness to stop the tax cuts for millionaires that may lead to cuts in Medicare, Medicaid, education. She is a member of the consulting group Democracy Partners.
Booth was the subject of the film Heather Booth: Changing the World, directed, written, and produced by Lilly Rivlin and released in 2016, which explores Booth's life as an organizer. Booth is also the subject of the HBO Documentary, The Janes which details her work as founder of the Jane Collective, an underground network of young women who provided safe abortions in pre–Roe v. Wade Chicago.
During the Biden/Harris presidential campaign of 2020, Booth served as director of senior and progressive engagement and on December 15 of that year was quoted as saying "President-elect Joe Biden's team has always focused on older voters and their concerns will be top-of-mind in his upcoming term."
The Janes with Heather Booth | Embrace Ambition Summit
Heather Booth: Changing the World - Trailer
If We Organize, We Can Change the World | Heather Booth | TEDx
Activists, Social Activism, Feminism Social Justice, Law, Civil Rights, Women's Rights, Political, Reproductive Rights, Influential Women, Women's Health, Women Empowerment, Pro-Choice, Women, Women in Society, Women's History Month,
The abortion underground and what lessons can be learned from the Jane Collective
In the likelihood that Roe v. Wade is overturned, Heather Booth, the founder of the Jane Collective, has two pieces of advice: "We need to come together. We need to organize."
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You are here: Home / Palo Alto / Palo Alto's Stanford Theatre
Palo Alto's Stanford Theatre
December 20, 2019 /in Palo Alto /by The Dawn Thomas Team
Photo by Charles Russo
Located on University Avenue in Palo Alto's charming downtown is the Stanford Theatre, a mainstay for almost a century. This independent movie house immortalizes the golden age of Hollywood by screening black and white classic films made between the 1920s and 1960s.
The theatre opened on June 9, 1925 and premiered I'll Show You The Town, a comedy starring Reginald Denny and Marian Nixon. The Stanford as its lovingly called, served as Palo Alto's leading film house for decades, with most classic movies debuting on its screen.
In 1988, the theatre was lackluster and showing its 63 years. Attendance was down and a For Sale sign appeared in its window. David Wooley Packard, son of David (Hewlett Packard co-founder) and Lucile Packard, decided to rent the venue and held a Fred Astaire Film Festival in honor of the actor's recent passing. The theatre held 1,175 people and was sold out nightly. Upon the conclusion of the festival, Packard convinced his parents to purchase the theatre through the David and Lucile Packard Foundation. The venue was restored to its original splendor and today, it is operated by the Stanford Theatre Foundation, led by President David Wooley Packard and managed by Cyndi Mortensen.
In a 2018 feature article about the movie house, Mortensen explains that she'd read an article about the venue being purchased by the Foundation. Her lifelong passion for classical films had her contacting David in 1988 and volunteering for him in 1990. "He invited me to come and work full time for him and I have worked for him since then. I have always been incredibly interested in and passionate about classic films and the importance of film preservation, because film doesn't last forever. I am very lucky—I get to work with the UCLA Film Archive, the Library of Congress, the George Eastman Museum, the Academe Film Archive. It's particularly important now because everyone is going digital. We are committed to the 35mm experience as some of these films become increasingly rare. Sometimes you can't get them from the studios or the studio vaults. I am very fortunate to be able to get these films from the archives. We are very blessed—very lucky—that we are able to do that."
The Stanford's refurbished Persian and Moorish grand neoclassical architecture dates back to an age when movie-going was truly an experience. Originally costing $300,000 to build, (which translates to well over $4 million today) the perfectly preserved theatre welcomes visitors in its palatial lobby and is adorned in reds and golds, including the quintessential red velvet curtain and plush seating. A Wurlitzer organ plays during intermissions before and after the 7:30pm show as well as provides a musical complement to all silent films.
Its illustrious legacy as a cinematic treasure restored, The Stanford attracts 25% of all classic film attendance in the United States. More people watched the 1992 50th anniversary showing of Casablanca at The Stanford than at any other film house in the US.
Since the theatre reopened its doors, David Wooley Packard has been intimately involved in all of the theatre's programming, having his finger firmly on the pulse of what the viewing public will appreciate. The films he chooses often feature a specific genre, director, timeframe or theme. During the holiday season, classics like It's a Wonderful Life (showing on December 24th) and Miracle on 34th Street may grace the screen. Currently, The Stanford is featuring the Films of 1939, which include Mr. Smith Goes to Washington, The Wizard of Oz and Gone with the Wind.
If you are a classic film aficionado, a visit to the Stanford Theatre provides the glitz and glamour of old time Hollywood. Enjoy popcorn and a soda as you sink into your seat, waiting for the velvet curtain to part and transport you back in time.
The Dawn Thomas Team guides nice people through Silicon Valley and Santa Cruz County real estate matters. Our mission is to help everyone find their place in this world. Contact us today and we can assist you in selling or buying your home.
Stanford Theatre
221 University Avenue, Palo Alto
Tickets are available at the box office on the day of the show.
$7 for adults, $5 for senior and under 18.
Cash and checks only-no debit or credit cards (neither are very Golden Age)
Tags: David and Lucille Packard Foundation, David Wooley Packard, Golden Age of Cinema, movie house, Palo Alto, Stanford Theatre
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Fort Lee, New Jersey Civil Procedure
Fort Lee, New Jersey Civil Procedures
Find the right Litigation attorney in Fort Lee, NJ
Litigation Lawyers in Fort Lee
In Fort Lee, New Jersey, "civil procedure" is a broad term that refers to all of the rules that govern the process of civil litigation. Procedural law (such as civil procedure) is distinguished from substantive law, which governs the rights and obligations that the civil justice system is designed to safeguard.
Like all laws, the rules of civil procedure in Fort Lee, New Jersey reflect certain values that society, through its elected representatives, wants to promote. So, the rules of civil procedure have the stated goal of ensuring that the justice system is fair, cost effective, efficient, and accessible to everyone who has a legitimate legal grievance.
Fort Lee, New Jersey's civil procedure rules can get pretty perplexing, however. They govern every aspect of a civil action, from the filing of the complaint, to discovery, and all the way through trial and appeals.
Major Fort Lee, New Jersey Civil Procedure Issues
Complaint: The initial, and perhaps most significant, part of filing a lawsuit in Fort Lee, New Jersey is the complaint. The complaint is filed with the court in Fort Lee, New Jersey that's responsible for handling civil trials. It lists everything that the plaintiff (the person who is suing) alleges against the defendant (the person the plaintiff is suing). Usually, but not always, the end of the complaint will contain a "prayer for relief." The prayer for relief is just a statement of what the plaintiff is asking the court to do to remedy the harm that the defendant allegedly caused.
Answer: Once the complaint is filed, the ball is in the defendant's court, so to speak. In the answer, the defendant has an chance to respond to all of the factual allegations made by the plaintiff, usually by denying them. The defendant might also raise affirmative defenses, which could keep the defendant from being held liable. For instance, if the defendant is accused of battery, and he did, in fact, batter the plaintiff, he might admit to that fact, but claim that the plaintiff was the aggressor, and he acted purely in self-defense. If he can prove that he acted in self-defense, he likely will not be held liable.
Discovery: Once the complaint and answer have been filed in a Fort Lee, New Jersey court, the next major civil procedure issue comes up. Discovery is the procedure in which both sides of the lawsuit are obligated to disclose obligated evidence to one another. The lawyers for each side can submit written questions, which the other party is required to answer under oath, unless the information is privileged. Each side can also request any relevant documents, physical evidence, and can conduct depositions of witnesses and parties to the lawsuit.
Trial: it's actually very uncommon for lawsuits to go trial in Fort Lee, New Jersey, because the rules of civil procedure in Fort Lee, and nearly everywhere else, encourage speedy resolution of legal disputes, before they ever see the inside of a courtroom. This is largely done by judges dismissing cases that clearly have no merit, or the parties settling out of court. Nonetheless, when neither of these things is possible, both sides of the lawsuit will have to hash it out in a trial, which can be the most stressful and expensive step in the process. It involves both sides of the case presenting their evidence and arguments to a jury and judge, and letting them determine the issues.
How Can a Fort Lee, New Jersey Lawyer Help?
If you're facing a lawsuit in Fort Lee, New Jersey whether as the plaintiff or defendant, you will have to interact with your jurisdiction's civil procedure rules.
In Fort Lee, New Jersey, procedural pitfalls can derail an otherwise-valid case. They can also be some of the most obtuse and convoluted issues in the whole case. Therefore, you should not go into something like this without the counsel of an attorney.
Fort Lee Civil Depositions Attorneys
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Convicted Sex Offender Owen Labrie Released Early from Jail for Good Behavior, Attorneys Say
Owen Labrie, the former New Hampshire prep school student convicted of sexually assaulting a 15-year-old girl, is out of Merrimack County's jail, his legal team said Monday.
"Owen is happy to be home with his family," his attorneys told ABC News. "He will be settling in and working on rebuilding his life. He'd like to thank the friends and family that have stood by him and supported him all these years."
Labrie served almost six months of the remaining 10 months of a year-long sentence, and was let go early based on good behavior, his attorneys said.
Prosecutors said that Labrie, now 23, sexually assaulted 15-year-old female student at St. Paul's School when he was 18. This was part of a ritual among seniors–the "Senior Salute"–to collect as many sexual encounters as possible with freshmen.
Labrie was convicted in 2015 of misdemeanor statutory rape, misdemeanor endangering the welfare of a child, and felony solicitation of a sex from a minor over a computer. Labrie had to register as a sex offender. His defense tried to argue the encounter was consensual, but prosecutors won out.
The defendant appealed his conviction, and was allowed to be out on bond until a judge determined that he violated his court-ordered curfew; he spent two months in jail. Labrie's defense continued to attempt to shorten his sentence, arguing that he had been punished enough. The judge didn't see it this way, and ordered him to begin serving the rest of the sentence.
Statement from victim's parents: "Today, the perpetrator who sexually assaulted our then 15 year old daughter will finally be held accountable for his crime and sent to jail to serve his sentence. To date, he has shown no remorse nor accepted any responsibility for his actions."
— Kim Lucey (@KimLucey) December 26, 2018
Owen Labrie


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Correlation and prediction of gene expression level from amino acid and dipeptide composition of its protein
Gajendra PS Raghava, Joon H Han
BMC Bioinformatics , 2005, DOI: 10.1186/1471-2105-6-59
Abstract: We compute the correlation between expression of a gene and amino acid composition of its protein. It was observed that some residues (like Ala, Gly, Arg and Val) have significant positive correlation (r > 0.20) and some other residues (Like Asp, Leu, Asn and Ser) have negative correlation (r < -0.15) with the expression of genes. A significant negative correlation (r = -0.18) was also found between length and gene expression. These observations indicate the relationship between percent composition and gene expression level. Thus, attempts have been made to develop a Support Vector Machine (SVM) based method for predicting the expression level of genes from its protein sequence. In this method the SVM is trained with proteins whose gene expression data is known in a given condition. Then trained SVM is used to predict the gene expression of other proteins of the same organism in the same condition. A correlation coefficient r = 0.70 was obtained between predicted and experimentally determined expression of genes, which improves from r = 0.70 to 0.72 when dipeptide composition was used instead of residue composition. The method was evaluated using 5-fold cross validation test. We also demonstrate that amino acid composition information along with gene expression data can be used for improving the function classification of proteins.There is a correlation between gene expression and amino acid composition that can be used to predict the expression level of genes up to a certain extent. A web server based on the above strategy has been developed for calculating the correlation between amino acid composition and gene expression and prediction of expression level http://kiwi.postech.ac.kr/raghava/lgepred/ webcite. This server will allow users to study the evolution from expression data.The use of microarray technologies to monitor gene expression in model organisms, cell lines and tissues has become an important part of biological research over the last several years. Ev
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The Feasibility of Enzyme Targeted Activation for Amino Acid/Dipeptide Monoester Prodrugs of Floxuridine; Cathepsin D as a Potential Targeted Enzyme [PDF]
Yasuhiro Tsume,Gordon L. Amidon
Molecules , 2012, DOI: 10.3390/molecules17043672
Abstract: The improvement of therapeutic efficacy for cancer agents has been a big challenge which includes the increase of tumor selectivity and the reduction of adverse effects at non-tumor sites. In order to achieve those goals, prodrug approaches have been extensively investigated. In this report, the potential activation enzymes for 5¢-amino acid/dipeptide monoester floxuridine prodrugs in pancreatic cancer cells were selected and the feasibility of enzyme specific activation of prodrugs was evaluated. All prodrugs exhibited the range of 3.0–105.7 min of half life in Capan-2 cell homogenate with the presence and the absence of selective enzyme inhibitors. 5¢-O-L-Phenylalanyl-L-tyrosyl-floxuridine exhibited longer half life only with the presence of pepstatin A. Human cathepsin B and D selectively hydrolized 5¢-O-L-phenylalanyl-L-tyrosylfloxuridine and 5¢-O-L-phenylalanyl-L-glycylfloxuridine compared to the other tested prodrugs. The wide range of growth inhibitory effect by floxuridine prodrugs in Capan-2 cells was observed due to the different affinities of prodrug promoieties to enyzmes. In conclusion, it is feasible to design prodrugs which are activated by specific enzymes. Cathepsin D might be a good candidate as a target enzyme for prodrug activation and 5¢-O-L-phenylalanyl-L-tyrosylfloxuridine may be the best candidate among the tested floxuridine prodrugs.
Amino Acid Properties Conserved in Molecular Evolution [PDF]
Witold R. Rudnicki, Teresa Mroczek, Pawe? Cudek
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0098983
Abstract: That amino acid properties are responsible for the way protein molecules evolve is natural and is also reasonably well supported both by the structure of the genetic code and, to a large extent, by the experimental measures of the amino acid similarity. Nevertheless, there remains a significant gap between observed similarity matrices and their reconstructions from amino acid properties. Therefore, we introduce a simple theoretical model of amino acid similarity matrices, which allows splitting the matrix into two parts – one that depends only on mutabilities of amino acids and another that depends on pairwise similarities between them. Then the new synthetic amino acid properties are derived from the pairwise similarities and used to reconstruct similarity matrices covering a wide range of information entropies. Our model allows us to explain up to 94% of the variability in the BLOSUM family of the amino acids similarity matrices in terms of amino acid properties. The new properties derived from amino acid similarity matrices correlate highly with properties known to be important for molecular evolution such as hydrophobicity, size, shape and charge of amino acids. This result closes the gap in our understanding of the influence of amino acids on evolution at the molecular level. The methods were applied to the single family of similarity matrices used often in general sequence homology searches, but it is general and can be used also for more specific matrices. The new synthetic properties can be used in analyzes of protein sequences in various biological applications.
Investigation of Chiral Molecular Micelles by NMR Spectroscopy and Molecular Dynamics Simulation [PDF]
Kevin F. Morris, Eugene J. Billiot, Fereshteh H. Billiot, Kenny B. Lipkowitz, William M. Southerland, Yayin Fang
Open Journal of Physical Chemistry (OJPC) , 2012, DOI: 10.4236/ojpc.2012.24032
Abstract: NMR spectroscopy and Molecular Dynamics (MD) simulation analyses of the chiral molecular micelles poly-(Sodium Undecyl-(L,L)-Leucine-Valine) (poly-SULV) and poly-(Sodium Undecyl-(L,L)-Valine-Leucine) (poly-(SUVL)) are reported. Both molecular micelles are used as chiral selectors in electrokinetic chromatography and each consists of covalently linked surfactant chains with chiral dipeptide headgroups. To provide experimental support for the structures from MD simulations, NOESY spectra were used to identify protons in close spatial proximity. Results from the NOESY analyses were then compared to radial distribution functions from MD simulations. In addition, the hydrodynamic radii of both molecular micelles were calculated from NMR-derived diffusion coefficients. Corresponding radii from the MD simulations were found to be in agreement with these experimental results. NMR diffusion experiments were also used to measure association constants for polar and non-polar binaphthyl analytes binding to both molecular micelles. Poly (SUVL) was found to bind the non-polar analyte enantiomers more strongly, while the more polar analyte enantiomers interacted more strongly with poly(SULV). MD simulations in turn showed that poly(SULV) had a more open structure that gave greater access for water molecules to the dipeptide headgroup region.
Molecular Evolution of Plant AAP and LHT Amino Acid Transporters [PDF]
Mechthild Tegeder,John M. Ward
Frontiers in Plant Science , 2012, DOI: 10.3389/fpls.2012.00021
Abstract: Nitrogen is an essential mineral nutrient and it is often transported within living organisms in its reduced form, as amino acids. Transport of amino acids across cellular membranes requires proteins, and here we report the phylogenetic analysis across taxa of two amino acid transporter families, the amino acid permeases (AAPs) and the lysine–histidine-like transporters (LHTs). We found that the two transporter families form two distinct groups in plants supporting the concept that both are essential. AAP transporters seem to be restricted to land plants. They were found in Selaginella moellendorffii and Physcomitrella patens but not in Chlorophyte, Charophyte, or Rhodophyte algae. AAPs were strongly represented in vascular plants, consistent with their major function in phloem (vascular tissue) loading of amino acids for sink nitrogen supply. LHTs on the other hand appeared prior to land plants. LHTs were not found in chlorophyte algae Chlamydomonas reinhardtii and Volvox carterii. However, the characean alga Klebsormidium flaccidum encodes KfLHT13 and phylogenetic analysis indicates that it is basal to land plant LHTs. This is consistent with the hypothesis that characean algae are ancestral to land plants. LHTs were also found in both S. moellendorffii and P. patens as well as in monocots and eudicots. To date, AAPs and LHTs have mainly been characterized in Arabidopsis (eudicots) and these studies provide clues to the functions of the newly identified homologs.
SCMCRYS: Predicting Protein Crystallization Using an Ensemble Scoring Card Method with Estimating Propensity Scores of P-Collocated Amino Acid Pairs [PDF]
Phasit Charoenkwan, Watshara Shoombuatong, Hua-Chin Lee, Jeerayut Chaijaruwanich, Hui-Ling Huang, Shinn-Ying Ho
Abstract: Existing methods for predicting protein crystallization obtain high accuracy using various types of complemented features and complex ensemble classifiers, such as support vector machine (SVM) and Random Forest classifiers. It is desirable to develop a simple and easily interpretable prediction method with informative sequence features to provide insights into protein crystallization. This study proposes an ensemble method, SCMCRYS, to predict protein crystallization, for which each classifier is built by using a scoring card method (SCM) with estimating propensity scores of p-collocated amino acid (AA) pairs (p = 0 for a dipeptide). The SCM classifier determines the crystallization of a sequence according to a weighted-sum score. The weights are the composition of the p-collocated AA pairs, and the propensity scores of these AA pairs are estimated using a statistic with optimization approach. SCMCRYS predicts the crystallization using a simple voting method from a number of SCM classifiers. The experimental results show that the single SCM classifier utilizing dipeptide composition with accuracy of 73.90% is comparable to the best previously-developed SVM-based classifier, SVM_POLY (74.6%), and our proposed SVM-based classifier utilizing the same dipeptide composition (77.55%). The SCMCRYS method with accuracy of 76.1% is comparable to the state-of-the-art ensemble methods PPCpred (76.8%) and RFCRYS (80.0%), which used the SVM and Random Forest classifiers, respectively. This study also investigates mutagenesis analysis based on SCM and the result reveals the hypothesis that the mutagenesis of surface residues Ala and Cys has large and small probabilities of enhancing protein crystallizability considering the estimated scores of crystallizability and solubility, melting point, molecular weight and conformational entropy of amino acids in a generalized condition. The propensity scores of amino acids and dipeptides for estimating the protein crystallizability can aid biologists in designing mutation of surface residues to enhance protein crystallizability. The source code of SCMCRYS is available at http://iclab.life.nctu.edu.tw/SCMCRYS/.
Extreme genetic code optimality from a molecular dynamics calculation of amino acid polar requirement [PDF]
Thomas Butler,Nigel Goldenfeld,Damien Mathew,Zaida Luthey-Schulten
Quantitative Biology , 2007,
Abstract: A molecular dynamics calculation of the amino acid polar requirement is presented and used to score the canonical genetic code. Monte Carlo simulation shows that this computational polar requirement has been optimized by the canonical genetic code more than any previously-known measure. These results strongly support the idea that the genetic code evolved from a communal state of life prior to the root of the modern ribosomal tree of life.
Middle Molecular Weight Heparinyl Amino Acid Derivatives (MHADs) Function as Indirect Radical Scavengers in Vitro [PDF]
Seiichi Takeda, Takao Toda, Kazuki Nakamura
Pharmacology & Pharmacy (PP) , 2016, DOI: 10.4236/pp.2016.73015
Abstract: We conducted the novel synthesis of middle molecular weight heparinyl amino acid derivatives (MHADs) to reduce the adverse effect of heparin (HE) based on its anticoagulant activity. Subsequently, we investigated the radical scavenging effects of 12 kinds of MHAD on cultured human umbilical vein endothelial cells (HUV-ECs) damaged by oxygen free radicals using xanthine and xanthine oxidase in vitro. As a result, middle molecular weight heparinyl phenylalanine, middle molecular weight heparinyl leucine, and middle molecular weight heparinyl tyrosine showed significant protective effects on HUV-ECs. In conclusion, these three HE derivatives might be candidates for therapeutic agents to treat diseases attributed to peroxidation.
Amino Acid Composition, Molecular Weight Distribution and Antioxidant Stability of Shrimp Processing Byproduct Hydrolysate [PDF]
J. Zhao,G.R. Huang,M.N. Zhang,W.W. Chen
American Journal of Food Technology , 2011,
Abstract: Protein hydrolysate have many practical applications in a various of industries due to the bioactive peptides related to their amino acid composition, sequence and molecular weight. The amino acid composition, molecular weight distribution and antioxidant stability of alcalase hydrolysate were investigated in this study. The hydrolysate was separated into five fractions by ultra filtration system with different molecular weight cutoff with 10, 5, 3 and 1 kDa, respectively. The protein content, 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and molecular weight of each fraction were determined. In addition, the antioxidant stability of the hydrolysate under several operating conditions was studied. The results showed that the hydrolysate was composed with high amounts of hydrophobic amino acids (40.4%) which might contribute to the high antioxidant activity. The fraction with molecular weight lower than 1 kDa exhibited the highest antioxidative activity among the five fractions. The antioxidant stability experiments showed that the hydrolysate was stable when it was heated up to 100C and the relative antioxidative activity could be maintained nearly 70% at very low pH of 2.0. Glucose and sucrose had negative effects on the antioxidative activity, in which the relative activity of about 80% was retained. Sodium chloride and sodium benzoate had little or no effects on the antioxidative activity of the hydrolysate. The effects of Zn2+ and Cu2+ on the antioxidative activity were significant and dependent on metal concentration. The shrimp processing byproduct hydrolysate may be a potential natural food antioxidant in the future.
Single amino acid substitution in important hemoglobinopathies does not disturb molecular function and biological process [cached]
International Journal of Nanomedicine , 2008,
Abstract: Viroj WiwanitkitDepartment of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, ThailandAbstract: Hemoglobin is an important protein found in the red cells of many animals. In humans, the hemoglobin is mainly distributed in the red blood cell. Single amino acid substitution is the main pathogenesis of most hemoglobin disorders. Here, the author used a new gene ontology technology to predict the molecular function and biological process of four important hemoglobin disorders with single substitution. The four studied important abnormal hemoglobins (Hb) with single substitution included Hb S, Hb E, Hb C, and Hb J-Baltimore. Using the GoFigure server, the molecular function and biological process in normal and abnormal hemoglobins was predicted. Compared with normal hemoglobin, all studied abnormal hemoglobins had the same function and biological process. This indicated that the overall function of oxygen transportation is not disturbed in the studied hemoglobin disorders. Clinical findings of oxygen depletion in abnormal hemoglobin should therefore be due to the other processes rather than genomics, proteomics, and expression levels.Keywords: hemoglobin, amino acid, substitution, function
Copyright © 2008-2017 Open Access Library. All rights reserved.


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Peyronie's Disease
peyronie's disease from injury
Post By Schneider
Sexual intercourse. adequate postinjury
Prospective cohort study comprised 68 men
Bundles (nvbs) occurs
Prostatectomy erectile dysfunction
This problem may be caused by a urinary tract infection, a neurologic disorder (multiple sclerosis, spinal cord injury, cerebrovascular accident), or the origin may be unknown. There are several.
The PD plaques are actually hardened scar tissue. It's widely believed that the disease is triggered by an injury to the erect penis-often one that goes unnoticed.
Penis Trauma: How it Happens. Penile Injury – or trauma – is one of the leading causes of penis curvature which can lead to Peyronie's Disease. In the case of.
In Peyronie disease, the tunica albuginea may initially undergo microvascular trauma during sexual intercourse. adequate postinjury fibrinolysis.
peyronie's disease review peyronie's disease without bend announced Friday an additional $8 million in Centers for Disease Control funding to support. start getting back to some variation of normal without widespread testing and robust contact tracing.A health overhaul promises to give greater health care options, increase prevention support and listen to Mori.
Some studies show the plaque begins to build up after some kind of trauma to the penis (most often during sex). Often the patient doesn't know right away that the.
This plaque may result from injury to the penis and/or genetic factors; however, the exact cause of Peyronie's disease is unknown. In a small percentage of men,
mild peyronie's disease pictures peyronie's disease patient information The patients in this prospective cohort study comprised 68 men with end-stage liver disease who were scheduled. and associated information was presented to each participant before LDLT.Peyronie's disease is the name for a sharp curve in the penis. In some men, Peyronie's disease is a mild problem without symptoms.mild case of peyronie's disease Symptoms can vary, but sometimes resemble toxic shock syndrome or Kawasaki disease. In some cases the affected children only had very mild COVID-19 before developing the inflammatory syndrome.
Nonetheless, whether it is one specific injury during sexual activity or repeated minor injuries, the inflamed tissue results in the formation of plaque (scar tissue).
However, it appears that injury to the neurovascular bundles (nvbs) occurs secondary to one or more factors such as excessive traction, use of thermal energy or direct damage during its dissection.
When scar tissue develops under the skin of the penis due to trauma or minor injury, Peyronie's disease may occur. As the scar tissue forms in the penis may.
Atherosclerosis is a disease with higher levels of mortality. and related diseases (e.g., aortic stenosis and ischemic injury). Using 2DE analysis was the first separation technique applied.
peyronie's disease in tamil peyronie's disease surgery before and after pictures Peyronie's disease is a disorder in which the penis bends or curves because of fibrotic scar, or plaque, that has formed within the penis. Depending on where the plaque is located, the penis will bend up,15 2020. How To Treat Peyronie's Disease with ESWT (Bent or Curved Penis)?. Explained in Tamil I Patient.
Some type of minor injury to the penis is likely what causes Peyronie's Disease. Such an injury could occur during vigorous sex, athletic activities,
Risk factors for vascular diseases include hypertension, hyperlipidemia, and coronary artery disease. Medications are also a very common cause of ED. Drugs that can cause erectile dysfunction include.
With younger and healthier men being diagnosed and treated for localized prostate cancer, postradical prostatectomy erectile dysfunction has become an ever more important matter of debate. However.
peyronie's disease percentage One of the most commonly used tests to distinguish psychogenic from organic erectile dysfunction (ED) is to monitor nocturnal penile tumescence using the RigiScan device and its new software.
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The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers
P. Widsten (Corresponding Author), S. Tuominen, Pia Qvintus-Leino, J.E. Laine
Helsinki University of Technology
Orion Oyj
This study was carried out to elucidate the effect of defibration temperature in the range 171–202°C on the properties of 12-mm thick MDF boards made without synthetic resins from softwood fibers activated by laccase treatment for the generation of phenoxy radicals on the fiber surfaces. Laccase treatment generated radicals in the fibers. An increase in defibration temperature improved the reactivity of fibers during laccase-catalyzed oxidation. The number of radicals detected in the fibers after laccase treatment in water suspension and the fiber oxygen consumption during the treatments increased with an increase in defibration temperature, while a concurrent improvement was observed in the mechanical strength and thickness swell of dry-process MDF boards made from fibers refined at different temperatures and treated with laccase in the refiner blowline. The different fiber reactivities or board properties were not due to a presence of different amounts of lignin remaining on the fiber surfaces after acetone extraction. The probable reason for them was the fact that the amount of low-molecular weight lignin, a reactive substrate for laccase, increases with increasing defibration temperature. The adhesion occurring during pressing is thus likely to involve coupling or other reactions of radicals located on adjacent fibers, whereby interfiber covalent bonds are formed.
Wood Science and Technology
fiberboards
defibration
Dive into the research topics of 'The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers'. Together they form a unique fingerprint.
Fiber Engineering 100%
Fibers Physics 100%
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Softwood Engineering 25%
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Widsten, P., Tuominen, S., Qvintus-Leino, P., & Laine, J. E. (2004). The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers. Wood Science and Technology, 38(7), 521 - 528. https://doi.org/10.1007/s00226-003-0206-4
Widsten, P. ; Tuominen, S. ; Qvintus-Leino, Pia et al. / The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers. In: Wood Science and Technology. 2004 ; Vol. 38, No. 7. pp. 521 - 528.
@article{4ebb3e2e91e542ce9223b33be96be06d,
title = "The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers",
abstract = "This study was carried out to elucidate the effect of defibration temperature in the range 171–202°C on the properties of 12-mm thick MDF boards made without synthetic resins from softwood fibers activated by laccase treatment for the generation of phenoxy radicals on the fiber surfaces. Laccase treatment generated radicals in the fibers. An increase in defibration temperature improved the reactivity of fibers during laccase-catalyzed oxidation. The number of radicals detected in the fibers after laccase treatment in water suspension and the fiber oxygen consumption during the treatments increased with an increase in defibration temperature, while a concurrent improvement was observed in the mechanical strength and thickness swell of dry-process MDF boards made from fibers refined at different temperatures and treated with laccase in the refiner blowline. The different fiber reactivities or board properties were not due to a presence of different amounts of lignin remaining on the fiber surfaces after acetone extraction. The probable reason for them was the fact that the amount of low-molecular weight lignin, a reactive substrate for laccase, increases with increasing defibration temperature. The adhesion occurring during pressing is thus likely to involve coupling or other reactions of radicals located on adjacent fibers, whereby interfiber covalent bonds are formed.",
keywords = "boards, fiberboards, MDF, defibration, laccase, heat treatment",
author = "P. Widsten and S. Tuominen and Pia Qvintus-Leino and J.E. Laine",
pages = "521 -- 528",
journal = "Wood Science and Technology",
Widsten, P, Tuominen, S, Qvintus-Leino, P & Laine, JE 2004, 'The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers', Wood Science and Technology, vol. 38, no. 7, pp. 521 - 528. https://doi.org/10.1007/s00226-003-0206-4
The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers. / Widsten, P. (Corresponding Author); Tuominen, S.; Qvintus-Leino, Pia et al.
In: Wood Science and Technology, Vol. 38, No. 7, 2004, p. 521 - 528.
T1 - The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers
AU - Widsten, P.
AU - Tuominen, S.
AU - Qvintus-Leino, Pia
AU - Laine, J.E.
N2 - This study was carried out to elucidate the effect of defibration temperature in the range 171–202°C on the properties of 12-mm thick MDF boards made without synthetic resins from softwood fibers activated by laccase treatment for the generation of phenoxy radicals on the fiber surfaces. Laccase treatment generated radicals in the fibers. An increase in defibration temperature improved the reactivity of fibers during laccase-catalyzed oxidation. The number of radicals detected in the fibers after laccase treatment in water suspension and the fiber oxygen consumption during the treatments increased with an increase in defibration temperature, while a concurrent improvement was observed in the mechanical strength and thickness swell of dry-process MDF boards made from fibers refined at different temperatures and treated with laccase in the refiner blowline. The different fiber reactivities or board properties were not due to a presence of different amounts of lignin remaining on the fiber surfaces after acetone extraction. The probable reason for them was the fact that the amount of low-molecular weight lignin, a reactive substrate for laccase, increases with increasing defibration temperature. The adhesion occurring during pressing is thus likely to involve coupling or other reactions of radicals located on adjacent fibers, whereby interfiber covalent bonds are formed.
AB - This study was carried out to elucidate the effect of defibration temperature in the range 171–202°C on the properties of 12-mm thick MDF boards made without synthetic resins from softwood fibers activated by laccase treatment for the generation of phenoxy radicals on the fiber surfaces. Laccase treatment generated radicals in the fibers. An increase in defibration temperature improved the reactivity of fibers during laccase-catalyzed oxidation. The number of radicals detected in the fibers after laccase treatment in water suspension and the fiber oxygen consumption during the treatments increased with an increase in defibration temperature, while a concurrent improvement was observed in the mechanical strength and thickness swell of dry-process MDF boards made from fibers refined at different temperatures and treated with laccase in the refiner blowline. The different fiber reactivities or board properties were not due to a presence of different amounts of lignin remaining on the fiber surfaces after acetone extraction. The probable reason for them was the fact that the amount of low-molecular weight lignin, a reactive substrate for laccase, increases with increasing defibration temperature. The adhesion occurring during pressing is thus likely to involve coupling or other reactions of radicals located on adjacent fibers, whereby interfiber covalent bonds are formed.
KW - boards
KW - fiberboards
KW - MDF
KW - defibration
KW - laccase
KW - heat treatment
JO - Wood Science and Technology
JF - Wood Science and Technology
Widsten P, Tuominen S, Qvintus-Leino P, Laine JE. The influence of high defibration temperature on the properties of medium-density fiberboard (MDF) made from laccase-treated softwood fibers. Wood Science and Technology. 2004;38(7):521 - 528. doi: 10.1007/s00226-003-0206-4


text:
Paradise Warriors
Mark Huxley and Ryan Huxley
Their synced vocal harmonies, elegant songwriting style,
and diverse musical palette, create a unique world of music.
Rock, Top 40, and the Californian Sound are comparable genres to the varied textures of PARADISE WARRIORS
PARADISE WARRIORS have come a long way in the past 20 years.
Brothers, Mark and Ryan Huxley, have performed to crowds of 3, all the way to 20,000 people.
With performances broadcasted on Commercial Television across the entire state of Western Australia,
the Warriors have also performed alongside Australian Idol runner up, Anthony Callea.
Mark and Ryan have had recordings broadcast on Nova 93.7FM on 'Nathan and Nat's Breakfast Show'.
Countless Corporate engagements have developed their stage presence and chemistry.
From their roots in Rock 'n' Roll, Disney, and Pop, PARADISE WARRIORS delved into Classical Music, and the musical stage and film.
Singing The Beach Boys, and The Everly Brothers' harmonies, would shape their vocal blend.
Their debut album, There's a Place, is a long time in the making, and arrival.
'There's A Place' is now available.
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