text:
York Research Database Home
Overview of the epidemiology of immunodeficiency-associated cancers.
V. Beral*, R. Newton
Cancer Research Unit
Immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. A common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. People with acquired immunodeficiency syndrome (AIDS) are at an increased risk of Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, squamous cell carcinoma of the conjunctiva, and childhood leiomyosarcoma. It is striking that most of these cancers have been associated with specific human herpesvirus (HHV) infections: HHV-8 with Kaposi's sarcoma and the closely related Epstein-Barr virus with non-Hodgkin's lymphoma, Hodgkin's disease, and possibly also with childhood leiomyosarcoma. Moreover, similar associations between these viruses and cancer have been found, albeit inconsistently, in people who are not immunosuppressed. Further research is needed to establish whether the risk of other cancers is also increased in people with AIDS, although, if so, the cancers are likely to be rare or to have comparatively small associated relative risks. Existing evidence suggests that there may be no marked increase in the risk of two common cancers that are known to be caused by infectious agents--hepatocellular carcinoma and invasive carcinoma of the uterine cervix. The apparent lack of an increase in invasive cervical cancer is unexpected and needs further investigation, especially since the prevalence of cervical infection with human papillomaviruses and of low-grade preneoplastic changes in the cervical epithelium is increased in women with AIDS. With the prospect of improved survival in people with AIDS, the effect of immunosuppression on cancer is likely to become an increasingly important issue.
Journal of the National Cancer Institute. Monographs
https://doi.org/10.1093/oxfordjournals.jncimonographs.a024164
Acquired Immunodeficiency Syndrome/complications
Neoplasms/complications
10.1093/oxfordjournals.jncimonographs.a024164
Beral, V., & Newton, R. (1998). Overview of the epidemiology of immunodeficiency-associated cancers. Journal of the National Cancer Institute. Monographs, (23), 1-6. https://doi.org/10.1093/oxfordjournals.jncimonographs.a024164
Beral, V. ; Newton, R. / Overview of the epidemiology of immunodeficiency-associated cancers. In: Journal of the National Cancer Institute. Monographs. 1998 ; No. 23. pp. 1-6.
@article{29f2690afe104ad7a45366b8c4676964,
title = "Overview of the epidemiology of immunodeficiency-associated cancers.",
abstract = "Immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. A common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. People with acquired immunodeficiency syndrome (AIDS) are at an increased risk of Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, squamous cell carcinoma of the conjunctiva, and childhood leiomyosarcoma. It is striking that most of these cancers have been associated with specific human herpesvirus (HHV) infections: HHV-8 with Kaposi's sarcoma and the closely related Epstein-Barr virus with non-Hodgkin's lymphoma, Hodgkin's disease, and possibly also with childhood leiomyosarcoma. Moreover, similar associations between these viruses and cancer have been found, albeit inconsistently, in people who are not immunosuppressed. Further research is needed to establish whether the risk of other cancers is also increased in people with AIDS, although, if so, the cancers are likely to be rare or to have comparatively small associated relative risks. Existing evidence suggests that there may be no marked increase in the risk of two common cancers that are known to be caused by infectious agents--hepatocellular carcinoma and invasive carcinoma of the uterine cervix. The apparent lack of an increase in invasive cervical cancer is unexpected and needs further investigation, especially since the prevalence of cervical infection with human papillomaviruses and of low-grade preneoplastic changes in the cervical epithelium is increased in women with AIDS. With the prospect of improved survival in people with AIDS, the effect of immunosuppression on cancer is likely to become an increasingly important issue.",
keywords = "Acquired Immunodeficiency Syndrome/complications, Adult, Child, Female, Humans, Neoplasms/complications",
author = "V. Beral and R. Newton",
doi = "10.1093/oxfordjournals.jncimonographs.a024164",
journal = "Journal of the National Cancer Institute. Monographs",
Beral, V & Newton, R 1998, 'Overview of the epidemiology of immunodeficiency-associated cancers.', Journal of the National Cancer Institute. Monographs, no. 23, pp. 1-6. https://doi.org/10.1093/oxfordjournals.jncimonographs.a024164
Overview of the epidemiology of immunodeficiency-associated cancers. / Beral, V.; Newton, R.
In: Journal of the National Cancer Institute. Monographs, No. 23, 1998, p. 1-6.
T1 - Overview of the epidemiology of immunodeficiency-associated cancers.
AU - Beral, V.
AU - Newton, R.
N2 - Immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. A common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. People with acquired immunodeficiency syndrome (AIDS) are at an increased risk of Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, squamous cell carcinoma of the conjunctiva, and childhood leiomyosarcoma. It is striking that most of these cancers have been associated with specific human herpesvirus (HHV) infections: HHV-8 with Kaposi's sarcoma and the closely related Epstein-Barr virus with non-Hodgkin's lymphoma, Hodgkin's disease, and possibly also with childhood leiomyosarcoma. Moreover, similar associations between these viruses and cancer have been found, albeit inconsistently, in people who are not immunosuppressed. Further research is needed to establish whether the risk of other cancers is also increased in people with AIDS, although, if so, the cancers are likely to be rare or to have comparatively small associated relative risks. Existing evidence suggests that there may be no marked increase in the risk of two common cancers that are known to be caused by infectious agents--hepatocellular carcinoma and invasive carcinoma of the uterine cervix. The apparent lack of an increase in invasive cervical cancer is unexpected and needs further investigation, especially since the prevalence of cervical infection with human papillomaviruses and of low-grade preneoplastic changes in the cervical epithelium is increased in women with AIDS. With the prospect of improved survival in people with AIDS, the effect of immunosuppression on cancer is likely to become an increasingly important issue.
AB - Immunodeficiency, be it congenital, therapeutic, or infectious in origin, increases the risk of certain, but not all, types of cancer. A common feature of these cancers is that specific infectious agents appear to be important in their etiology, not only in immunodeficient subjects but also in the general population. People with acquired immunodeficiency syndrome (AIDS) are at an increased risk of Kaposi's sarcoma, non-Hodgkin's lymphoma, Hodgkin's disease, squamous cell carcinoma of the conjunctiva, and childhood leiomyosarcoma. It is striking that most of these cancers have been associated with specific human herpesvirus (HHV) infections: HHV-8 with Kaposi's sarcoma and the closely related Epstein-Barr virus with non-Hodgkin's lymphoma, Hodgkin's disease, and possibly also with childhood leiomyosarcoma. Moreover, similar associations between these viruses and cancer have been found, albeit inconsistently, in people who are not immunosuppressed. Further research is needed to establish whether the risk of other cancers is also increased in people with AIDS, although, if so, the cancers are likely to be rare or to have comparatively small associated relative risks. Existing evidence suggests that there may be no marked increase in the risk of two common cancers that are known to be caused by infectious agents--hepatocellular carcinoma and invasive carcinoma of the uterine cervix. The apparent lack of an increase in invasive cervical cancer is unexpected and needs further investigation, especially since the prevalence of cervical infection with human papillomaviruses and of low-grade preneoplastic changes in the cervical epithelium is increased in women with AIDS. With the prospect of improved survival in people with AIDS, the effect of immunosuppression on cancer is likely to become an increasingly important issue.
KW - Acquired Immunodeficiency Syndrome/complications
KW - Adult
KW - Child
KW - Female
KW - Neoplasms/complications
U2 - 10.1093/oxfordjournals.jncimonographs.a024164
DO - 10.1093/oxfordjournals.jncimonographs.a024164
JO - Journal of the National Cancer Institute. Monographs
JF - Journal of the National Cancer Institute. Monographs
Beral V, Newton R. Overview of the epidemiology of immunodeficiency-associated cancers. Journal of the National Cancer Institute. Monographs. 1998;(23):1-6. doi: 10.1093/oxfordjournals.jncimonographs.a024164
York Research Database data protection policy


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TILT Announces Expansion of Jupiter…
TILT Announces Expansion of Jupiter Distribution in California
Jupiter's proprietary inhalation technology continues rapid growth with the integration of Baker and Blackbird software and services
CAMBRIDGE, Mass., April 22, 2019–(BUSINESS WIRE)– TILT Holdings Inc. ("TILT" or the "Company") ("TILT") (CSE: TILT) (OTCQB: SVVTF), a leading provider of products and services to businesses operating in the cannabis industry, today announced that Jupiter Research, LLC ("Jupiter"), a leader in inhalation and vaporization technology and wholly owned subsidiary of TILT, has further expanded distribution of its proprietary, high-performance technologies in California through its integration with TILT's software and supply chain services. The expansion allows Jupiter to establish a physical presence with increased geographic reach throughout California, enabling TILT to develop stronger customer relationships and deliver Jupiter products to B2B customers more quickly than ever before.
TILT acquired Jupiter in early 2019 to further expand its technology ecosystem and B2B reach across the supply chain. Through this acquisition, Jupiter has accelerated its growth with additional distribution opportunities leveraging TILT's software, logistics and supply chain services provided by Blackbird Logistics ("Blackbird") and Baker Technologies, Inc. ("Baker"). The integration of TILT's operations and software solutions, combined with its robust distribution services allows Jupiter to provide support to its more than 640 customers in California with just-in-time inventory fulfillment and services.
At TILT our vision is to help cannabis businesses better serve their customers and patients by providing them the tools to communicate, operate, and scale with a greater degree of efficiency.
Alex Coleman, Chief Executive Officer of TILT Holdings
Through Jupiter's expansion with Blackbird and Baker, Jupiter customers benefit from partnered solutions and shared expertise pivotal for success in the global cannabis economy. The continued integration of our businesses is driving cross-selling opportunities that deliver more value to our customers and increased revenue opportunities for TILT.
As more and more consumers prefer inhalation devices, Jupiter is an industry leader in vaporization technologies. Jupiter produces power supplies and cartridges specifically designed for cannabis oil in the market today, featuring Jupiter's proprietary ceramic CCELL technology. Jupiter's team has decades of combined experience in vaporization partners with more than 800 brands and cannabis retailers across the United States ("U.S."), Canada, Israel and the E.U.
About TILT
TILT is a leading provider of products and services to businesses operating in the cannabis industry. The Company offers the contract manufacturing of marijuana in a variety of form factors, vaporizer and inhalation devices, business and consumer delivery services and a broad suite of software products for over 1,500 retailers and brands throughout the U.S., Canada and Europe. The majority of TILT's products are customized to client specifications and branding, all enabling them to operate their businesses more efficiently and connect with their customers more effectively. The Company is organized in two main business units, Software & Services and Consumer Devices & Packaged Goods, designed to augment competencies across the organization in research, manufacturing, packaging and technology to deliver end-to-end services and customer solutions. All of TILT's products are supported by an extensive research process led by scientists and engineers, using data analytics and discovery to produce new products helping shape the industry. Headquartered in Cambridge, MA, with offices throughout the U.S., Toronto and London, TILT has over 500 employees and has sales in 40 U.S. states, Canada and Europe. For more information, please visit www.tiltholdings.com.
Jupiter, Jupiter Research, svvtf, TILT, Tilt holdings, tiltf
TILT Holdings Announces Tim Conder as Chief Operating Officer
TILT Holdings Begins Sale of up to $125 Million 8% Convertible Notes
TILT Releases July Update Letter From CEO
Global Cannabis Stock Index Declines 2.2% in June

redpajama_set_name: RedPajamaCommonCrawl


text:
Coronavirus Pandemic Leaves Renting Cheaper than Buying
13 June 2021 | General
Research from Hamptons shows that pandemic-led forces mean it is now cheaper to rent than buy a home for the first time since December 2014.
For a first-time buyer with a typical 10 per cent deposit*, it was £71 per month (or 7 per cent) cheaper for them to rent a home in Great Britain in May 2021 than it was to buy it. This means they would have spent a monthly average of £1,054 on rent compared to £1,125 on mortgage repayments.
This is in contrast to March 2020 – the eve of the pandemic – when a purchaser with a 10 per cent deposit would have been £102 per month better off buying than renting.
Despite rents in Great Britain rising 7.1 per cent over the last 12 months, strong house price growth coupled with increases in higher loan-to-value (LTV) mortgage rates have added to the cost of buying and owning a home.
In early 2020 it was cheaper to buy than rent in every region of the country. However, since the onset of the pandemic, this trend has reversed. In May 2021 it was cheaper to rent than buy in seven of Great Britain's 11 regions. The three northern regions (North East, North West, Yorkshire & Humber) and Scotland bucked the trend and were the only places where it was cheaper to buy.
London has seen the largest shift since the start of the pandemic. A buyer putting down a 10 per cent deposit on a property in the capital will have gone from being £123 per month better off buying in March 2020, to spending £251 per month less on rent in May 2021.
Falling rents in the capital have made renting cheaper relative to buying by a bigger margin than anywhere else. And with rents still falling, the differential looks set to continue growing.
For buyers with just a 5 per cent deposit, renting becomes even cheaper than buying on a monthly basis. This is in part due to the increase in interest rates on 95 per cent LTV mortgages over the course of the pandemic. A buyer putting down a 5 per cent deposit will on average spend £195 per month (or 19 per cent) more than if they had carried on renting.
Rental growth accelerated in May to reach a new record high. Last month the average cost of a newly let rental home in Great Britain rose to £1,054 pcm, up 7.1 per cent on the same time last year. This marked the fastest rate of growth since our records began in 2013, surpassing the previous peak of 7.0 per cent in December 2014.
While rents bottomed out in May last year in the middle of the pandemic, the average rental home cost £43 or 4.1 per cent more than it did in May 2019.
Four out of the eight regions recorded record rental growth last month – the South East, South West, Midlands and Scotland. Rents in the South East and South West hit double digits for the second consecutive month, rising 13.0 per cent and 11.5 per cent respectively. Meanwhile London continued to be the only region where rents fell (-0.5 per cent year-on-year).
Rents rose faster on larger properties. In May the average rent on a four-bed property in Great Britain increased to £1,805 pcm, up 9.5 per cent on the same month last year. Meanwhile rents on one-bedroom homes remained flat at 0.4 per cent.
Aneisha Beveridge, Head of Research at Hamptons, said: "The pandemic has reversed a six-year trend which now makes it cheaper to rent than buy a home. A year ago, lenders were either increasing their rates or withdrawing higher loan-to-value mortgages altogether. For first-time buyers in particular this pushed up the cost of paying a mortgage, if they could get one at all, to well above the cost of renting. It is likely the balance will swing back somewhat towards buying, particularly as mortgage rates come down. However this is likely to be partly offset by rising house prices. And while interest rates are falling, they're still considerably above where they were pre-pandemic on higher loan-to-value loans. Despite this, we expect the gap between renting and buying to close over the remainder of this year, moving back towards longer-term levels in 2022."
This post has originally been featured in Property Wire.
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CE Log In
ADL Log In
Our Mission / Core Values / Leadership
UNC Health Sciences at MAHEC
MAHEC in the News
Read Our Stories
Center for Psychiatry and Mental Wellness
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Log In to MyCE Area
Conference Mgmt Services
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AHEC Scholars
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Safer Pain Management & Substance Use
From Patient to Physician
CHPE Student Profile: AHEC Scholar Devan Woody
Devan Woody didn't want to let a back injury keep him from playing football, but eventually it did. He spent the majority of his time at Mountain Heritage High School in Burnsville, NC, injuring his back, working to get better, playing football, reinjuring it, and starting all over. It wasn't until his senior year when, after signing to play college football at Mars Hill University, he injured it for the final time.
His football career was over, but, more importantly, he needed to find a new college to attend because not playing football meant his scholarship would be revoked.
"It was so late in the year that I basically called every local university and said, 'Hey, can I come there?'" Devan said. "Western Carolina University picked up the phone, and said, 'Sure.'"
During all of this turmoil, Devan was dealt another hard blow. He found out that he had inherited polycystic kidney disease (PKD), a chronic condition that his father, aunt, and grandfather also have.
"My kidneys will likely fail by age 60 to 65, and I will have to be put on dialysis and then eventually need a transplant," Devan explained. "It's a genetic disease, and my sister and I both had a 50/50 shot of getting it. We both drew the short stick."
However, all of the time he spent as a patient did lead to something positive: he decided to become a physician. Now a pre-med biology major in his senior year at Western Carolina University, he's working towards getting into medical school. His ultimate goal is to become a nephrologist who specializes in diseases of the kidneys including PKD.
"I will be a patient the rest of my life," said Devan. "My experience as a patient is what's driven me to want to practice medicine. I've been on that end a lot. I know what it's like, and I think sometimes you can get frustrated on the patient side. I want to be a physician who makes it a little less frustrating."
In order to be that physician, Devan believes his focus should be on treating the whole person. As a second-year AHEC Scholar at MAHEC, he's been inspired by the didactics where students learn about various medical specialties and how to work with other healthcare professionals to reach a common goal.
"If we truly believe in patient outcomes, I think you have to treat the person as a whole and not just treat the symptoms. And if you treat a person as a whole, sometimes you have to use information that you're not a specialist in, so that's what our (AHEC Scholars) didactics are all about," said Devan. "They teach you an interdisciplinary approach, and you learn things that you wouldn't learn in your normal studies."
As he's applying for medical school, Devan's keeping his ultimate career goals in mind. UNC Chapel Hill is his first choice because "they value reaching underserved communities and rural medicine. I come from a rural area that's underserved, and that's my goal – to practice in a rural area like Burnsville or other rural communities in this area," explained Devan.
As an AHEC Scholar, he's well on his way to achieving his goal.
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June 04, 2014 Opinion » Editorial
The State Legislature: Our Absentee Parent
For decades, Oregon resisted hosting an annual legislative session. It was one of the final states to finally concede that leadership requires at least a meeting of its lawmakers every year, and in 2012, installed an annual session. But even now, its new concession barely seems to qualify as an annual legislature; during even-numbered years, it only meets for a month-long session.
This half-hearted attempt to become a full-time legislature fully fails to provide the leadership and consistency necessary to manage a state as politically and socially diverse as Oregon—a reality that is becoming especially clear after its recent month-long session in February, and current long-term absence until next January.
Exhibit A: The civil wars breaking out in towns and counties throughout Oregon over the conflicting laws about medical marijuana dispensaries.
In the regular 2013 session, the state legislature voted to allow medical marijuana dispensaries to operate within Oregon—a reasonable consideration given that 15 years ago voters in the state approved the use of marijuana for predetermined ailments, like cancer and chronic pain. SInce 1998, under the voter approved law, patients with pre-approved aliments have been allowed to possess and grow limited amounts of marijuana, strictly for medicinal purposes. That law, however, was incomplete, essentially approving the demand-side for medical marijuana, but leaving the legality of the supply-side vaguely defined. The Oregon state legislature's action in 2013 allowing medical dispensaries took a step toward logic and clarity: As long as medical marijuana is legal, approved both by the majority of voters and the legislature, there should be public and regulated businesses that can provide safe and monitored transactions.
But then, in February, in its single-month "annual" session, those very same people, the state legislators, hurriedly ratcheted back their own allowances by voting for a senate bill permitting local municipalities to ban such dispensaries until 2015. It was a patch-up job, something meant to hold the matter in place until law makers reconvene in January.
In practice, however, that decision has been like lighting a fuse on a bomb and then walking out of the room. It has made a mess, and one that there is no higher authority to clean up.
The battles are hottest in southern Oregon, where cities like Medford have issued permanent bans against dispensaries, with one city councilor there boldly declaring, "We have the authority to have a moratorium regardless of the state action"—a statement bordering on anarchy. It is even worse in Phoenix, a small town of 5,000, midpoint between Medford and Ashland, where it wouldn't be completely surprising if townfolks show up to this week's city council meeting with pitchforks and torches. At the heart of the debate in Phoenix is a dispensary called the Greenery. Over the past few years, city council there has routinely fined the Greenery for operating without a license; and, just as fast, a circuit court has dismissed the charges (32 times!). With the legal ambiguity created by the state legislature, the Phoenix city council has taken the opportunity to up its prosecution of the Greenery, so much so that at the last city council meeting, 24 people came out to speak on behalf of the dispensary—and medical marijuana in general. Yet, in response, the city council eliminated future public testimony on the topic and, this week, votes on whether to increase the fine for operating a dispensary from $100 a day, to $500. It also apparently has earmarked $50,000 for legal fees to prosecute the owner of the Greenery—a ginormous sum for a small town.
In Central Oregon, the climate is also primed for such civil wars: There are already faultlines showing, as Bend allows dispensaries, but Deschutes County does not.
Without a full-time legislature, Oregon will remain ruled by a wild west mentality, where various cities and small towns like Phoenix don't pay heed to the prevailing laws and sentiments.
Cliff Bentz should not waste his chance to lead
Yes, Cliff Bentz Failed Oregonians
Letters to the Editor 1/21/21
2020's Local Wins and Losses: The Boot and Slipper Return!
Under New Guidance, Districts Can Decide When to Re-Open. So When Will They?
Drop Dud, Gorgeous & Fate Club
More Editorial »
A call for wearing masks from an essential worker, ideas for the meat industry and more in this week's letters
GUEST OPINION: To our elected officials and government leaders
Give a Pint - Get a Pint - Blood Drive - Trampoline Zone
Latest in Editorial
Rep. Cliff Bentz (R-Ontario), voted against certifying Pennsylvania's electoral votes, and then doubled down and voted against impeaching the current president More »
Bentz may now face the wrath of a corporate America, where more companies are vowing to withhold campaign contributions More »
After Oregon's Devastating Fires, Protect Public Lands
There's a massive effort underway to not only rebuild homes and sometimes entire towns, but also to clean up the mess the fires made More »


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Pascal F. Egea
pegea@mednet.ucla.edu
Boyer Hall room 356
611 Charles E Young Drive East
Cell Biology and Cell Signaling
Position Titles
Assistant Professor, Biological Chemistry
Pascal Egea received is B.S. in Molecular and Cellular Biology from the Ecole Normale Supérieure de Lyon (Lyon, France) in 1991. He then went to graduate school at the Université Louis Pasteur (Strasbourg, France) where he studied the structure and function of the retinoic acid receptors in the laboratory of Dr Dino Moras. After completing is Ph.D. in 1999, Pascal went to the University of California in San Francisco for post-doctoral training under the co-mentorship of Professors Robert Stroud and Peter Walter; during this period he studied the signal recognition particle and protein translocation pathways. Pascal joined the Department of Biological Chemistry as an assistant professor in the fall of 2009.
Research Description
Structure and Function of Eukaryotic Membrane Protein Complexes Linked To Diseases
Most biological functions come about through the orchestrated interactions between macromolecules assembled into complexes. Membrane proteins account for ~25% of any given proteome and are the targets for ~50% of the therapeutic drugs in use today; yet very few three-dimensional structures of these valuable targets are known. Research in the Egea lab focuses on two specific eukaryotic membrane protein complexes studied at the level of their molecular structure to elucidate their mechanism of action and cellular functions. Because of their extreme complexity (in terms of molecular size and conformational flexibility) we apply a hybrid methods strategy to tackle these challenging assemblies. Our computational and structural approach combines X-ray crystallography to cryo-electron microscopy and solution scattering to close the resolution gap existing between the crystal structures of individual subunits and the experimental reconstructions of larger complexes and further validate our models.
Targeting a protein export complex for drug design in Plasmodium falciparum, the parasite causing malaria. Malaria is the world's most important disease caused by a parasite. Nearly 10% of the world's population is infected with malaria, which kills more than one million persons each year, with vast social and economic consequences. Modern research on malaria seeks to identify biological processes that are unique to the parasite. Such processes once characterized can be targeted for drug design. Pathogenesis in malaria almost entirely occurs at the red blood cell stage. The ability of the parasite to infect, remodel, and replicate in human erythrocytes is central to the pathogenesis of the disease. These processes are mediated in part by a large number of secreted essential parasite proteins that are transported across the vacuolar membrane via a parasite-derived translocon and delivered into the erythrocyte cytoplasm. The Plasmodium Translocon of Exported Proteins (PTEX) is a newly discovered membrane protein complex solely responsible for this export and thus represents an Achilles heel in the parasitic life cycle. This pathway is specific to the Plasmodium. Because vacuolar protein export is essential in Plasmodium, this process represents an ideal target for the design of novel therapies to treat and ultimately contribute to the eradication of the disease. The challenges posed by malaria reside in the rapid and recurrent emergence of resistance to existing anti-malarial therapies and the overall poor chemical diversity of the drugs at hand. PTEX is a large (2.5 MDa) membrane-bound complex composed of at least five subunits. We seek to characterize the structure of some of its key components to understand the mechanisms of export and guide the rational-design of novel classes of anti-malarial drugs: specific inhibitors of parasitic protein export.
The structure and functions of an inter-organelle tethering complex. How and why organelles communicate within the eukaryotic cell? Eukaryotic cells are characterized by a complex and interconnected network of membrane-bound organelles. Although cellular compartmentalization enables the efficient segregation of metabolic processes, the membranes that delineate these organelles impose a physical barrier impeding the exchange of matter and information. To overcome this problem, eukaryotic cells exploit membrane contact sites (MCSs), or regions of proximity between two organelles, to allow the transfer of metabolites. These MCSs serve as nexuses for the exchange of lipids and small molecules crucial to cellular life and homeostasis. Various protein complexes, such as the endoplasmic reticulum-mitochondrial encounter structure (ERMES), function as dynamic molecular tethers between organelles. ERMES is composed of five subunits; the absence of structural data has precluded answering questions such as how the subunits are organized to function as a tether, and whether they do indeed bind and exchange lipids at MCSs. Ultimately, the lack of structural insight undermines the understanding of function. We thus seek to reconstitute the entire ERMES. Although we use yeast as a model organism, MCSs are present in all eukaryotic cells. In humans, dysfunctional MCSs are associated with cancer and neurodegenerative diseases such as Parkinson and Alzheimer. Thus, answering a basic science question by studying a model system from yeast will have profound implications in human health sciences.
2014-2015 Stein-Oppenheimer Award, UCLA
2013-2018 Alexander and Renée Kolin Endowed Professorship of Molecular Biology and Biophysics
2012-2014 Scholar in Translational Medicine Program Award, UCLA


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Women Group Condemns Slave Trade in Libya
Nov 30, 2017News0Like
Modern Women of Wisdom International (MWOW) an Advocacy women group Africa has joined numerous organisations and individuals in the world in condemning the slave trade of some African countries in Libya.
A statement issued by the Women Organisation expressed sadness over the matter and stressed the need for African communities to take swift initiative to curtail such scandalous abuses of human rights.
Pictures of slave markets and gross abuse of black Africans are awash on social media after CNN uncovered the fledging human trade in the North African country.
The horrible images show some migrants being sold for $400 while others are tortured to death by individuals in Libyan military wears.
Some Africans have condemned the apparent silence of the continent's leaders over the development as the AU, ECOWAS and other known regional blocks are yet to comment on the issue.
MWOW indicated that, ''as a matter of urgency, we seek the emancipation of all the captives and clearly, the AU has a role to play in areas such as ensuring the release of the victims and punishing the perpetrators".
"As a humanitarian organization aimed at saving lives and preserving human dignity, we found this heinous crime morally undignified and humanely unjustifiable'', it said.
Read the full statement
We the members of Modern Women of Wisdom International are not only raising the awareness of the presence of slave trade activities in Libya; we vehemently condemn the preposterous exhibition of racism and atrocious display of slave trade in Libya.
As a humanitarian organization aimed at saving lives and preserving human dignity, we found this heinous crime morally undignified and humanely unjustifiable.
Just when we thought the horror which once existed at the idea of a slave master armed with a dagger, whips, cutlass and guns inflicting pains on slaves was over because slave trade was abolished in 1883, we recently woke up to find human beings bundled and being shipped into foreign countries at a cost of 300 pounds/400 dollars per head in Libya.
As a compassionate NGO, we found the animosity exercised by the captors towards the captives very horrible and we feel the moral imperative to speak out against this barbarism.
Truth be told, no state in the 21st Century prospers by thriving on slave trade. Slave trade belongs to the Stone age. There are now better and more efficient strategies like free trade and free labour that boosts the economy of nations
As a matter of urgency, we seek the emancipation of all the captives and clearly, the AU has a role to play in areas such as ensuring the release of the victims and punishing the perpetrators.
The AU's commitment to the respect of fundamental human rights must be enshrined and enforced in its treaty.
Again, we humbly call upon the International Community to step up their discussions and rescue strategies as a matter of urgency before the worst happens.
We can't afford to look unconcerned as Africans because the by- standing effect will either make others feel threatened or encourage others to embark on similar activities.
It is our fervent hope and desire that the International community responds rapidly by rushing to the rescue of all the black captives in Libya.
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Multi-Games
» Beginner's Guide to Ping Pong
Reviews of the Best Folding Pool Tables – 2021
Reviews of the Best Mini Tabletop Pool Tables – 2021
Reviews of the Best Air Hockey Tables for Kids – 2021
Reviews of the Best Air Hockey Pucks and Paddles – 2021
Reviews of the Best Pool Table Covers – 2021
Beginner's Guide to Ping Pong
/ By	Alberto Restrepo
This page may contain affiliate links. If you make a purchase through one of our affiliate links, we'll earn a commission, at no extra cost to you.
Ping pong (or table tennis) is a favorite option in many gamerooms. It's a fun and exciting game that can be played by 2 or 4 people, and you can even practice by yourself if you want to. All you need to play is a ping pong table, a net, a few paddles, and a ball.
Ping Pong vs. Table Tennis
Before we get into the details of the article, you may be wondering, "what is the difference between ping pong and table tennis?" The answer is, nothing except the name. You may have heard that there are differences in the rules or differences in the tables, but that is not correct. It is the same game, just two different names. For recreational players it is often called ping pong, but serious tournament players will usually call it table tennis. Since our audience is mostly people who will be playing for fun at home, we'll go with ping pong.
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Basic Rules of Ping Pong
The first player, or team if you're playing doubles, to reach 11 points wins the game. However, you must win by two points, so if the score is 11-10 the game will continue until one player achieves a two-point lead.
Matches are made up of multiple games. It could be best of 3, best of 5, or best of 7. For example, if the match is best of 5, the first player to win 3 games will be the winner of the match.
There is no set rule to determine who serves first. You could flip a coin or decide some other way.
One player will serve the ball two times, and then the other player will serve the ball two times. You'll go back-and-forth like this throughout the game, switching every two serves.
After each game, the players switch sides of the table.
Ping Pong Table Height and Dimensions
An official ping pong table is:
9 feet long (2.74 meters)
5 feet wide (1.525 meters)
2 feet 6 inches high (76 cm)
The net is 6 inches (15.25 cm) high
The size of ping pong tables can vary, but for tournaments and competitions us the standard size and regulations listed above.
How to Serve in Ping Pong
You must have the ball in front of you in view of the opponent, not hidden behind your arm or anything else.
You must throw the ball at least six inches straight up in the air, not towards your opponent or towards yourself.
After you throw the ball in the air you hit it, and it must bounce once on your side of the table, go over the net, and then bounce once on the other side of the table.
The center line on the table is not relevant if you are playing singles. If you are playing doubles you must serve diagonally (meaning, you serve from the right side and the ball must go over the net and land on the left side (from your perspective) of the opponent's side of the table.
If the serve touches the net but goes over the net and hits the other side of the table, it is called a "let" and the serve is re-done.
For a more detailed explanation, see my article Ping Pong Serving Rules.
Letting the Ball Bounce
Unlike in tennis, you must let the ball bounce on your side of the table before hitting it. You cannot hit it out of the air.
That basically covers the rules of the game. It's pretty simple, especially once you start playing. Ping pong is a great game that will bring hours of entertainment in your home. If you don't already have a ping pong table, it is one of our top recommendations for your game room.
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About the Author	Alberto Restrepo
I live in Pennsylvania with my wife and four children. Time with family is very important to me, so I started Gameroom Vault to help others find fun ways to spend time with their families at home.
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