Thagubothu Ramesh rose to popularity through the films like Mahatma, Ala Modalaindi, Pilla Zamindar , Ishq and etc. Ramesh is a native of Godavari Khani in Karimnagar District, while his father was an employee of Singareni Calories, while his mother is a housewife. Thagubothu Ramesh was popular in his town as a mimicri artiste and he did several shows there, before entering film industry.