She first got her break in 1989 as a member of the legendary political rap group X-Clan under the alias of Isis at the age of 20, and she went on to release a few singles and one album as Isis, 1990's "Rebel Soul", before departing from X-Clan in 1992 and thus retiring the Isis alias. Instead, Que would go on to release a few singles under her real name, although she would resurrect the Isis alias once more in 1996 when she became a member of the all-female rap supergroup Deadly Venoms. After recording a few singles and one album with the group, 1998's "Antidote", she would then depart from the group in 1999 after numerous disputes with the other members of Deadly Venoms.