Mesereau was the second lawyer for actor Robert Blake's case (not trial) over the murder of his wife Bonnie Lee Bakley. Blake's first attorney Harland Braun resigned over Blake's decision to appear in a televised interview with Diane Sawyer against Braun's advice and counsel. Mesereau and his co-counsel and law partner, Susan Yu, later withdrew from the case due to differences with Blake. After Mesereau and Yu withdrew, Blake hired another lawyer and was eventually acquitted. In 2004, Mesereau and Susan Yu were hired to replace attorneys Mark Geragos and Ben Brafman as lead trial counsel. The trial lasted from January 2005 through June 2005. Jackson was found not guilty. Barbara Walters named him one of the year’s "Ten Most Fascinating People". GQ Magazine named him one of its "Men of the Year".