She is also the Medical Liaison of The University of Arizona HealthCare Partnership and an Internist in clinical practice at the Southern Arizona Veterans Affairs Health Care System. Dr. Gilles has served as the Principal Investigator for clinical trials, studying the efficacy of medications for the treatment of Tobacco Use Disorder. She is the former Medical Director of the Arizona Program for Nicotine and Tobacco Research, as well as the Southern Arizona Veterans Affairs Smoking Cessation Program. Dr. Gilles has designed and implemented physician and allied health professional educational curricula addressing tobacco dependence treatment.