In 1979 he received his University degree in Medicine and Surgery at Second Medical school of Naples, Italy. He was Board Certified in General surgery in 1984 and in Cardiovascular Surgery in 1990. From 1982 to 1983 he spent a Research Fellowship in pediatric cardiac surgery at the Academich Medich Zentrum, Amsterdam, The Nederland. From 1985 to date he was appointed at the Department of Cardiac Surgery of the University School of Medicine and Surgery Federico II, Naples – Italy. Dr. Vito Antonio Mannacio's research interests focus on Cardiac Surgery, Arterial conduits for Coronary Artery Bypass Graft, Off-pump CABG, Patient prosthesis mismatch after Aortic Valve Replacement, Myocardial metabolism and structure, Statin use in coronary surgery.