In the early 1980s, she worked for the Star newspaper and Style magazine. By the mid-80s, she had joined Afrapix, a photographic collective that documented the anti-apartheid struggle. In 1994, she was among the photographers commissioned by the Independent Electoral Commission (IEC) to document the first democratic elections in South Africa. In post-apartheid South Africa, Wulfsohn has worked on assignment for numerous local and international publications and non-government organizations. She is primarily concerned with gender issues, education, and health. She has been documenting the manifestations of HIV/AIDS in South Africa since the late 1980s.