After receiving his PhD in 2006 at Georgia Tech, he worked as an NRSA Postdoctoral Fellow at Emory University where he helped produce some of the first published genome-wide maps of insertion/deletion (indel) variation in human populations and develop technologies to derive their genotypes using microarrays. As a Research Associate at Harvard Medical School, he expanded the scope of his work into the mapping of larger structural and copy number variation as part of the 1000 Genomes and other projects. His current research is focused on developing methods for the identification, resolution and analysis of complex genomic rearrangements consisting of multiple breakpoints that are the result of overlapping or co-occurring structural changes to the genome.