He is also a member of the IU Simon Cancer Center, the IU Center for Computational Biology and Bioinformatics, and the Indiana Institute for Personalized Medicine. His research focuses on the use of next-generation sequencing in translational oncology. In particular, his laboratory concentrates on the use of next-generation sequencing for drug development and pharmacogenomics, and for understanding mutational causes of cancer. In addition, a major focus of his work is the integration of next-generation sequencing into cancer clinical trials, with a special focus on using genomics for precision medicine.