Her research interests are pain, evidence-based medicine and clinical epidemiology. She has published a number of research manuscripts and mentored multiple young researchers in diploma, MSc and PhD theses. She is reviewer for numerous peer-reviewed journals and funding agencies. Prof. Puljak was founder and inaugural director of Cochrane Croatia, an organization established at the University of Split School of Medicine in Croatia with the purpose of promoting evidence-based medicine. In Cochrane Croatia she currently serves as a Knowledge Translation Coordinator.