Dr. Kubinak's broad research interest is understanding the genetic pathways regulating B lymphocyte development and serum/mucosal antibody responses. More specifically, his lab is currently focused on 1) understanding how mucosal IgA responses regulate the microbiome and host health, 2) contrasting the role of different immune signaling pathways on B cell development and mucosal IgA responses in the gut, and 3) understanding the influence of genetic variation at MHCII gene loci on susceptibility to infection. His lab is also interested in identifying genes that underlie enhanced levels of bacteremia during steady-state conditions. Dr. Kubinak's work has practical implications for the identification of biomarkers that can predict risk of septicemia and susceptibility to diseases linked to common variable immunodeficiency (CVID) syndrome in humans.