His research focuses on Aquatic Toxicology and Molecular Endocrinology using fish models. Recent studies are mainly on transgenic fish over-expressing somatolactin hormone for functional study and use of biomarkers of exposures to study the risk of environmental contaminants including pesticides, trace organics, nanoparticles, and metal ions in waters. Dr. Chan also studies the regulation of eukaryotic gene expression and transcription, focusing on understanding how metal-regulatory-element-binding transcription factors (MTFs) control metallothionein genes and how Pit-1s control pituitary polypeptide hormone genes.