He graduated from Duke University School of Medicine, and completed both his internal medicine and psychiatry residencies at Duke Hospital. He has published articles about race and medicine in a variety of publications, including the New York Times, Washington Post, Raleigh News & Observer, JAMA, and Annals of Internal Medicine. His memoir, Black Man in a White Coat: A Doctor’s Reflections on Race and Medicine, was published in 2015 and lauded as a New York Times Bestseller and one of TIME magazine’s top ten non-fiction books of the year. In his book, Dr. Tweedy examines his early life in a segregated, working-class background and the complex interplay between race and medicine.