He is co-chair holder of the International Life Cycle Chair (a research unit of CIRAIG) and also teaches Life Cycle Assessment and sustainable manufacturing classes. His research activities aim to develop life cycle based tools to support sustainable production and consumption with a focus on the assessment of life cycle impacts, risks and benefits related to existing and new products, processes, and services. In parallel with his research activities, Manuele gained considerable experience working together with industry co-founding two spin-off: Ecointesys and Quantis International, where he still retains a key advisory role.