He is a structural biochemist with research interests in poly(ADP-ribose) metabolism and signaling, DNA damage response, nucleic acid enzymology, and cancer drug discovery. His research has been focused on the structure, mechanism, and drug discovery of key enzymes in poly(ADP-ribose) metabolism and DNA repair. He joined the faculty at University of Cincinnati in 2016 as part of the Cancer Cluster Hiring Initiative and continues his research.