Her work focuses on Byzantium and the medieval Mediterranean, more specifically aesthetics, phenomenology, and acoustics. Bissera has three published books: Icons of Power: The Mother of God in Byzantium (Penn Sate Press, 2006), The Sensual Icon: Space Ritual and the Senses in Byzantium (Penn State Press, 2010), and Hagia Sophia: Sound, Space, and Spirit in Byzantium (Penn State Press, 2017).