In 1992 Luzietti was hired at Interplay, where he began mostly on sound effects and miscellaneous audio work. He didn't start composing full soundtracks until around 1994. Luzietti stayed with Interplay when it went public in 1998, but left shortly after when they started having financial difficulties. In 1999, he started working at Visual Concepts Entertainment as their audio director, where he continues to work to this day. Brian is probably best known for composing the soundtrack to Wolfenstein 3D for the Macintosh and the 3DO version's title music which was remixed by Todd Dennis.