Her research and teaching focuses on the development, testing and dissemination of prevention and treatment interven­tions targeting the co-occurrence of HIV/STI risk behaviors, substance abuse, interpersonal violence, trauma and related issues among vulnerable populations. Witte’s current work focuses on dissemination and implementation of evidence-based interventions using multimedia and Internet-based technology to community based agencies; and developing structural HIV/STI risk reduction for street-based sex workers by infusing savings-led microfinance components for economic independence. Witte is an investigator on several NIH-funded research studies. Her work has been presented and published in peer-reviewed venues nationally and globally.