Her central research focus is to develop and apply innovative statistical methods to solve challenging data analysis problems in three biomedical research areas: 1) high-throughput metagenomics/microbiome/genetics data analysis, 2) complex survey methodology, and 3) biomedical collaborative research. She is the director of Metagenomic/Microbiomic Data Analysis Group in Department of Population health. With NIH’s support, her research group has been focused on developing novel statistical methods in analyzing metagenomics and microbiome data, including microbiome association test, longitudinal microbiome data analysis, and microbiome causal/mediation modeling.