Khandelwal is board certified in internal medicine and rheumatology and serves as an attending physician at Rush University Medical Center and the John H. Stroger, Jr. Hospital of Cook County. She is director of the Rush Connective Tissue Disease Clinic and co-director of the Rush Osteoporosis Treatment Center. Dr. Khandelwal received her medical degree from Michigan State University College of Human Medicine. She completed her residency in internal medicine at Rush University Medical Center, where she served as a chief resident, followed by a fellowship in rheumatology at Rush.