Her laboratory research focuses on the identification of molecular determinants of the leukemic niche, using chronic lymphocytic leukemia (CLL) and Richter’s syndrome as experimental models. Dr. Deaglio has contributed to the molecular and functional characterization of recurrently mutated genes in chronic lymphoproliferative syndromes of the B series. More recently, she was a visiting associate professor at Weill Cornell Medicine, where set up patient-derived xenograft models of CLL and Richter syndrome. These models can be useful in the development and testing of targeted therapies.