Spiros has many years of clinical, scientific research, and academic experience, and has held faculty appointments at the NYU Langone Medical Center and The Icahn School of Medicine at Mount Sinai Medical Center. He has also worked collaboratively on a number of initiatives with senior management members from biopharmaceutical companies, including Gilead and Pharmasset. Spiros is the inventor of SBI1997, and has been the leader of the effort to develop its clinical use in humans.