Wylie seeks to develop new modes of studying and intervening in large-scale environmental health issues through a fusion of social scientific, scientific and art/design practices, and is engaged in developing open-source research projects on low cost thermal imaging, low cost imaging of water pollution, community-based methods for detection of hydrogen sulfide among other civic science projects. Her book, Fractivism: Corporate Bodies and Chemical Bonds published by Duke University Press is an ethnographic study of the role science based NGOs played in the emergence of public concerns about the human and environmental health impacts of chemicals used in natural gas extraction, particularly hydraulic fracturing.