After he obtained his Ph.D in Animal Genetics and Breeding, he left China in 2003 and studied in USA. He did his postdoctoral training at Michigan University and Institute of Genetic medicine at Johns Hopokins University from 2005.6 to 2010.12. His major research interest combines biochemical, anatomical, molecular biology and transgenic animal model approaches to answer fundamental questions of mitophagy dysfunction in mtROS / NLRP3 inflammasome activation in the pathogenesis of type 2 diabetes.