His research interests are in geriatric psychiatry and cross-cultural psychiatry. Dr. Chen directed a participating site in a multi-site, randomized trial comparing the provision of psychiatric care that was closely integrated into primary care with psychiatric care provided via an enhanced referral model. Dr. Chen then went on to direct the statistical analyses conducted by the coordinating center for these multiple sites. In his other area of interest, Dr. Chen has investigated the ways in which culture influences the clinical presentation of depression in Asian immigrants. His findings pointed to the importance of self-attention and culturally shaped valuation of the self in shaping depressive symptomatology. Dr. Chen’s work has been supported by HRSA and SAMHSA.