In 2000, he founded the architecture practice Gramazio & Kohler in conjunction with his partner Matthias Kohler, where numerous award-wining designs have been realised. Current projects include the design of the Empa NEST research platform, a future living and working laboratory for sustainable building construction. As professors, Gramazio and Kohler developed the first architectural robotic laboratory at ETH Zurich (Gramazio Kohler Research, ETH Zurich, Switzerland). The ensuing research has been highly influential in the field of digital architecture, setting precedence and initiating a new research field focusing on the integration of industrial robots in architectural design and construction.