His research focuses on improving the interpretation of clinical patient data by using mathematical models. The models are based on fundamental physical and physiological principles, and can be used to predict how (pathologic) tissue or organ properties are manifested in patient data. When used in an inverse mode, the models provide a tool to transform these patient data back into an estimate of the underlying pathology. This model assisted diagnosis may be complemented by model assisted treatment selection and long-term prognosis. Application areas include Cardiac Electromechanics and Perioperative Monitoring, both in collaboration with the Catharina Hospital in Eindhoven. Application in Perinatal Monitoring is pursued in collaboration with the Máxima Medical Center in Veldhoven.