Dr Macaluso’s research focuses on understanding the molecular mechanisms underlying epigenetic and genetic alterations in human cells leading to cancer formation and progression. Her interest is to investigate the complex network of signals by which pRb family proteins regulate cellular proliferation, survival and differentiation, and to disclose the mechanisms responsible for the regulatory disruption of these functions in the neoplastic process. Dr. Macaluso’s research has been supported by the Department of Defense Breast Cancer Research Program, by National Institute of Health (NIH), several private foundations and organizations. She can be reached at macaluso[at]temple.edu