He leads the Venom Evolution Laboratory, working on venoms from a wide diversity of reptiles, centipedes, cnidarians, insects, scorpions, spiders and even venomous mammals. He has published extensively on venom systems evolution and how they can be harnessed for therapeutic use. His discoveries include antifreeze venom in Antarctic octopuses, komodo dragon venom and new species of sea snakes. Fry's publications have appeared in prestigious scientific journals, including Nature. He has led field expeditions to over forty countries and he is a member of the Explorers Club. His work has been featured in over seventy natural history documentaries appearing on Animal Planet, BBC, Discovery Channel, National Geographic TV and others.