He trained in Pediatrics at Washington University, and received degrees in Biostatistics and Epidemiology in 1989 from Johns Hopkins University, where he is currently in the Oncology Center's Division of Biostatistics. As statistician for the Hopkins Oncology Center, General Clinical Research Center and Pediatric Clinical Research Unit, he has participated in the design and analysis of a wide range of clinical and epidemiologic studies. He has served as Statistical Editor at the Annals of Internal Medicine since 1987, and been on a variety of NIH committees. His research interests include meta-analysis, statistical inference, the ethics of clinical trials, and the use of likelihood and Bayesian methodology in clinical research.