Wiley conducts research on how individuals and families remain resilient in the face of stress and challenge, with a recent focus on immigrant families. She has a special focus on the needs of Spanish-speaking families in the U.S. who face health disparities and are at heightened risk of poor outcomes. She is interested in identifying how resources such as quality childcare can improve family outcomes. Some of her published work is in Family Relations and in Child Development. Wiley is also interested in promoting wellness through her outreach work. She has created and tested curricula and materials to help people achieve healthy lifestyles.