His group is interested in the complex gene regulatory behaviors that are encoded by the epigenome and chromatin systems. These include the properties of gene expression memory, genetic imprinting, and dynamic signal processing. To study these properties, his group develops synthetic biology and molecular approaches to interface with and perturb the epigenome of cells. In addition, they are applying these tools to understand disease mechanisms, particularly in neural systems. Ongoing projects in the group are related to: cerebral organoid engineering; Autism, Angelman Syndrome, and Addiction; basic chromatin mechanisms in yeast; and exploiting DNA as a potential extreme-density storage medium for digital information.