His major research interest is in neurogenetics, with the long-term goal of understanding the genetic architecture of neuropsychiatric disorders. His group is resequencing neurodegeneration-related genes, and the whole genome, from a large series of patients with neurodegenerative conditions, including Alzheimer's disease and frontotemporal dementia. They are also collecting peripheral blood samples from patients with neurodegenerative dementia and studying global gene expression and methylation profiles using microarrays. In a related project, they are also using peripheral gene expression data in Friedreich's ataxia patients and animal models to characterize the effect of compounds with therapeutic potential.