His research focuses on chemical and genetic approaches to studying diseases of the blood and the circulatory system. His group uses high-throughput chemical screens in intact zebrafish to identify small molecules that perturb normal development or that suppress disease phenotypes in zebrafish disease models. With these small molecules, his laboratory can investigate different biological processes, including arterial-venous fate specification, cardiac chamber patterning and hematopoietic differentiation. In addition, some of the disease-suppressing compounds with therapeutic potential can be further studied using zebrafish and mammalian models of disease.