During his 17-year tenure at Johns Hopkins, Segev has made numerous, significant contributions, including development of a mathematical model to facilitate a nationwide paired kidney exchange program. Segev’s research focuses on medical data modeling, simulation, and analysis of large health care data sets. He is also principal investigator of a large multicenter cohort study investigating the relationship between frailty, outcomes on dialysis and outcomes following kidney transplantation. His clinical focus is on minimally invasive (laparoscopic) donor surgery and incompatible organ transplantation, including kidney exchange.