He treats patients primarily at UCSF Medical Center at Mount Zion and the UCSF Helen Diller Family Comprehensive Cancer Center. His research focuses on the molecular biology, genetics and treatment of thyroid cancer as well as the use of minimally invasive surgery. Shen also has an interest in medical history and has studied the development of hormonal therapies for benign and malignant conditions and the impact of the 1942 Coconut Grove Fire in Boston on the evolution of surface treatment for burns.