Her specialization is in extractive metallurgy, and in particular, mineral processing, hydrometallurgy, biohydrometallurgy and the treatment of industrial and mining effluents. She holds a Diploma of Imperial College (DIC) in Hydrometallurgy and a PhD in Minerals Engineering from Imperial College, London in the United Kingdom. She has over 12 years of experience in the Metallurgical Engineering field. Sehliselo currently holds a DST/NRF SARChI Professorial Chair in Hydrometallurgy and Sustainable Development at the University of Witwatersrand.