Stedman Nutrition and Metabolism Center and the Duke Molecular Physiology Institute. Dr. Koves' research interests are focused on understanding mitochondrial alterations that occur in skeletal muscle as a result of aging and chronic disease. Using metabolic profiling tools, he hopes to elucidate specific metabolite patterns of lipid-induced stress that could predict mitochondrial functional decline and seeks to understand how adaptations in response to exercise confer protection against age- and lipid-induced mitochondrial and muscle dysfunction.