Russo made her television series debut in 1987, with a supporting role in the ABC series Sable.Two years later, she made her debut in film as the girlfriend of the Tom Berenger character in Major League (1989) . Her breakthrough role is generally considered to be her part as internal affairs detective Lorna Cole in Lethal Weapon 3 (1992) and Lethal Weapon 4 (1998). Rene Russo with Mel Gibson in Lethal Weapon 3 Rene Russo in a scene from Major League