He received his MD from UHS/The Chicago Medical School and completed his medicine residency and gastroenterology fellowship at Loyola University Medical Center. Losurdo's clinical practice focuses on interventional endoscopy, hepatobiliary system, pancreas, advanced therapeutics procedures, Barrett's esophagus, and colorectal cancer. His research focuses on endoscopic procedures, pancreas, and Barrett's. Losurdo is the director of endoscopy at Rush. ​