For many years she worked at the department of culture of the Abovyan Region of Armenia and for the weekly newspaper "Voice of Motherland" of the Committee for cultural connections with Armenian Diaspora, first heading the cultural department, then as head of Diaspora department. During the first years of independence of Armenia, she worked at the Office of the President of the Republic of Armenia, as a chief specialist. In 1999-2002, she worked at the Board for the publishing and information at the Government of the Republic of Armenia, as a head of publishing and printing art department. Till 2010 she worked at the Publishing Issues Agency of the Ministry of Culture of Armenia as a head of publishing and printing art department. Now Seyranuhi Geghamyan is Head of the Contemporary Art Department of the Ministry of Culture of Armenia. She is the author of 12 books and numerous articles in the sphere of oration and cultural studies.