He has been leading the computational and algorithmic developments of the E-Cell Project, a scientific project developing necessary theoretical supports, technologies and software platforms to allow precise whole cell-scale simulation. He founded the project in 1996, and the E-Cell Consortium in 2002, with Prof. Masaru Tomita and colleagues. He is an initial member of the SBML (Systems Biology Markup Language) Forum. He earned his Ph.D. from Keio University in 2004.