His work at Henderson involves researching the molecular mechanisms by which diabetes mellitus promotes the progression and development of cardiovascular disease. His laboratory employs a broad range of molecular and cellular techniques to examine cell and tissue-specific responses to hyperglycemia. This includes identifying changes in atherosclerotic gene expression induced by hyperglycemia and determining the mechanisms of accelerated atherosclerosis in diabetic mouse models and human blood samples. His laboratory is especially interested in identifying and testing potential new targets for therapeutic intervention in the treatment and prevention of atherothrombotic cardiovascular disease.