The proposed research project aims to develop point-of-care devices for highly sensitive and real-time diagnosis of cardiovascular disease such as acute myocardial infarction. The transformative amplifying nanowire field-effect transistor sensor concept will maximize the intrinsic detection sensitivity with minimal noise contribution. Funds are requested to purchase surface immobilization chemicals and cardiac biomarker antibody solutions, and support professional travels specific to the project. Dr. Chui received his Ph.D. degree in Electrical Engineering from Stanford University, CA. After which he joined Intel Corporation as a Senior Device Engineer and Research-in-Residence at UC Berkeley and Stanford.