Her research focusing on the advancement of physiologic computational modeling so that clinically relevant questions can be asked and answered, improving disease diagnosis and treatment. Her recent research has led to patent filings in the fields of virtual surgery and cancer diagnostics. Through this work and her experience teaching the biomedical engineering capstone design class, Dr. Vigmostad has had the opportunity to become involved with several entrepreneurial activities, including serving as an instructor and mentor to entrepreneurial teams in Venture School, as well as forming a start-up company with her colleague, Michael Henry, that focuses on developing tools to enable faster and more accurate cancer diagnoses.