Over the past two decades, Brush’s research has spanned a gamut of nurse workforce issues, including workforce diversity, nurse shortage, and nurse migration, as well as direct care provision to vulnerable populations. Her research with homeless families in Detroit uses a community-based participatory approach to engage academic and community partners in designing and implementing best practice models to inform health policy decisions for this emerging and underserved cohort. Brush’s health workforce and clinical research has been supported by the National Institutes of Health, the National Library of Medicine, and private foundations and has been disseminated in over 50 peer reviewed articles, two books, and numerous book chapters.