Dr. Siegal studies how complex biological traits evolve, by studying the gene networks that underlie the development of these traits. His work integrates experimental and computational approaches, and ranges from investigations of sexual development in fruit flies to analyses of microscopic differences in the shapes of yeast cells. His work is supported by a National Science Foundation CAREER Award (2007–2012), and by research grants from the National Institutes of Health (2010–2014) and United States-Israel Binational Science Foundation (2010–2013).