She received her MD from Guangxi Medical University in Guangxi, China and her PhD in Neuroscience and Cell Biology from Tokai University School of Medicine, Japan. Dr. Guo’s research focuses on studying the molecular mechanisms of neurodegeneration induced by genetic mutations and environmental toxicants in Parkinson’s disease; with a particular emphasis on defining the signaling pathway mediating neurodegenerative processes include apoptosis, inflammation and blood-brain barrier dysfunction. Her research goal is to utilize activated protein C and its variants as a new therapeutic approach for treatment of Parkinson’s disease and other neuro-degenerative disorders. Dr Guo's experimental approach is to use both genetic and toxicant induced cell culture and mouse models of Parkinson’s disease.