Ngeze was a founding member and leadership figure in the Coalition for the Defence of the Republic, a Rwandan Hutu fascist political party that is known for helping to incite the genocide. Ngeze is best known for publishing the "Hutu Ten Commandments" in the December edition of Kangura in 1990, which were essential in creating and spreading the anti-Tutsi feeling among Rwandan Hutus that led to the Rwandan Genocide.