Chessler’s focus is on the pancreatic islets and the insulin-producing beta cells. Gaining an understanding of these cells is important for diabetes and also has direct relevance to insulinoma and other neuroendocrine cancers: indeed, much of his work utilizes insulinoma-derived cells. Chessler is interested in pancreatic islet/beta cell imaging; such technology could aid in the localization of insulinoma and other neuroendocrine tumors. His work toward gaining a better understanding of pancreatic islet, beta cell and insulimona cell development and function could yield new targets for the treatment of glucagonoma, insulinoma and other neuroendocrine cancers; Chessler has been appointed as a full member in the Systems, Pathways & Targets Program.