Dr. Kalajzic is principal investigator of an NIAMS research grant that focuses on understanding the biological processes involved in mending broken bones (fractures). He is studying the role of the Notch signaling pathway in an effort to identify components that could be manipulated to accelerate fracture healing. His lab has been using mouse models in which Notch signaling is altered to gain insights into the cells, molecules, and mechanisms involved in the process. Using the STAR funding, Dr. Kalajzic’s lab will further explore the role of Notch receptors in fracture repair. Ultimately, he hopes to use new knowledge about the Notch receptors to identify and evaluate candidate treatments for broken bones.