His research interest in bioengineering began with his PhD, designing software to characterise the geometry and architecture of the heart for individual-specific models of cardiac electromechanics. As a postdoctoral fellow at the McGill University Bioinstrumentation Laboratory (now at MIT), this interest widened to biomedical instrumentation design and construction. His research interests focus on computational, instrumentation, and experimental aspects of model-based measurement and analysis of biological systems. He directs groups developing models of skin, breast, and childbirth. He is also the leader of the CellML project, an open international effort to encode mathematical models of biological systems using a high-level XML-based description language. © NZCSRSC 2009