He graduated from the Architecture School of Paris-Villemin, and has worked in various architecture agencies in Paris, including l’Atelier Jean Nouvel. During those years, he conducted many projects in Lebanon, including the Campus of Innovation and Sports at Saint Joseph University (USJ). In 2008, he founded his own agency in Beirut, Youssef Tohme Architects and Associates (YTAA). Among his many projects, he participated to the planning of the Brazza district in Bordeaux and the construction of MARe (Muzeul de Artă Recentă/ Museum of Recent Art) in Bucharest. His Beirut-based agency has been selected to conceive the famous eleven-story wood tower in Nantes. Tohme has been awarded the Young Arab Architects Competition award (CA'ASI, Institute of the Arab World, Paris, 2012).