The proposed research project seeks to define signaling pathways regulating cell survival under metabolic stress, how these pathways function in cancer progression and means to target these pathways as cancer treatment. Funds are requested to purchase chemicals, antibodies and real-time qPCR reagents that are required for this research. Dr. Kong received B.S. in Biology from East China Normal University, her M.S. in Cell Biology from Shanghai Institute of Cell Biology and Ph.D. in Experimental Medicine from McGill University, Canada. She did her postdoctoral work at the University of Pennsylvania.