Her initial training is in bioinformatics and modeling of biological systems. During her PhD, she built the Aevol computational framework to study the structural evolution of microbial genomes. Her research interests are the evolution of genome size and structure, the evolution of gene networks, the evolution of mutational robustness and variability, and the evolution of evolvability. She builds computational and mathematical models of evolving populations to study these properties. She recently coordinated a two-years interdisciplinary project called «Analyze, simulate and experiment the evolution of bacterial genomes», involving five partners from microbiology, bioinformatics, mathematics and computer science.