Her laboratory investigates the molecular mechanisms and biological consequences of stimulus-regulated transcription in the CNS. Shes use molecular genetic model systems, sophisticated behavioral analyses, biochemical and cell biological methods, and high-throughput sequencing techniques to elucidate the mechanisms by which transcriptional regulatory proteins promote neuronal adaptations to changes in the environment. In addition to enhancing understanding of normal brain development and plasticity, her studies are revealing new insights into how dysregulation of gene transcription contributes to cognitive impairment and mental illness.