Her research focuses on the biological basis of neurocognitive functioning in aging, development, and mental illness. Previous studies have used functional imaging to explore the nature of cognitive deficits among older individuals with schizophrenia. Her current projects include examining the brain response correlates of exceptional aging and a study of brain functioning among older persons with bipolar disorder. In addition, she is a co-investigator on a twin MRI study of aging, a project to examine imaging correlates of risk for Alzheimer's disease, a study of enhancing the informed consent process among patients with schizophrenia, and a functional imaging project aimed at discovering risk factors for autism among very young children.