His major clinical and research focus is on the early care of patients with acute neurological illness and injury, with an emphasis on stroke treatment. He serves as a site principal investigator on the CLEAR-ER acute stroke trial, and is a co-investigator on several acute stroke treatment trials. He works as a co-investigator for the clinical coordinating center for the Neurological Emergencies Treatment Trials (NETT) Network. In addition, he has an interest in the incorporation of flexible Bayesian adaptive clinical trial designs into confirmatory phase neurological emergency trial.