Dr. De Jesus specializes in treating gastrointestinal malignancies with a specific focus in pancreatic cancer. Her clinical research interests are developing new treatments for localized or advanced pancreatic cancer. Dr. De Jesus leads translational clinical trials testing novel therapies and hedgehog inhibitors in this disease. Her studies are evaluating how these agents may target the pancreatic cancer stem cells, tumor microenvironment and affect the intratumor drug delivery in patients with pancreatic cancer. Dr. De Jesus also investigates mechanisms of resistance in pancreatic cancer.