She has both written sketches for, and performed in sketches on, Saturday Night Live. She starred in the Sarah Silverman Program from 2007-2010 that aired on Comedy Central. She was nominated to win a primetime Emmy Award in the category of Outstanding Lead Actress in a Comedy Series. She published an autobiography in 2010 she called The Bedwetter. She starred in Who's the Caboose, School of Rock, and Wreck It Ralph.