In 2013, while a postdoctoral fellow in Dafna Bar-Sagi’s laboratory at NYU, Dr. Commisso led a team that discovered how macropinocytosis supports tumor growth by serving as an amino acid supply route in RAS-driven cancers. His lab is focused on understanding the molecular basis of RAS-induced macropinocytosis, and the impact of metabolic heterogeneity on tumorigenesis and targeted cancer therapies.