Jo's main research area is Alzheimer's disease, which is the most common form of dementia. Her recent research has focussed on developing a portable biosensor as cheap and easy way of diagnosing Alzheimer’s disease sooner. Recently, Jo invented a new biochemical method which she named “midland blotting” in homage to her Leicester roots. During her Wellcome Trust-funded PhD at the University of Leeds, she studied the structural and molecular biology of Alzheimer’s disease.