Dr. Busse’s clinical interests include insurance medicine, orthopedic trauma, chronic pain and other medically unexplained syndromes, and management of complex disability. He is the Co-Principal Investigator of the TRUST trial, a multi-centre, randomized controlled trial of low-intensity, pulsed ultrasound bone-stimulation in patients undergoing intramedullary nailing for tibial fracture. Dr. Busse is also interested in methodological research including, for example, expertise-based randomization and the use of composite endpoints in clinical trials.