His scientific interest is in the understanding the systemic effects of Huntington’s Disease, especially metabolic changes, which he studies using a mouse knock-in model of Huntington’s Disease. He also has an interest in gene silencing approaches to Huntington ’s disease therapeutics, particularly using antisense oligonucleotides (ASOs). Jeff’s PhD and postdoctoral studies all involved using mouse models to understand basic mechanisms of Huntington’s disease and preclinical testing of therapeutic interventions in these models. During his PhD he trained with Michael Hayden (UBC) and his postdoctoral studies were conducted under the supervision of Marcy MacDonald (MGH, Harvard Medical School). As well as conducting research, Jeff is a member of an Huntington’s disease family and himself carries the mutation which causes the disease.