He has extensive experience in the identification and characterization of low-level peptide and protein samples (>16 yrs). A main focus of his work has been the optimization of differential expression strategies for the characterization of complex protein mixtures from mammalian tissue and cell-lines. Over the last ten years he has been developing methods for the effective extraction and digestion of extracellular matrix proteins in collaboration with leading cancer biologists, bioengineers and a team of scientists from the Colorado Museum of Nature and Science.