His current primary research interests include mesenchymal stem cell-based tissue-engineering and cell-based therapies, particularly of cartilage and bone. A major line of work focusses on understanding and meeting the metabolic demands of differentiating stem cells, both through optimization of the cell population and through enhancement of mass-transport in the developing engineered cartilage. Other interests include the development of required ancillary technologies for cartilage tissue engineering, such as bioreactors and monitoring and imaging techniques as well as computer modelling, mechanobiology, and bone grafting and bone-graft substitutes.