She has taught human anatomy and physiology as well as pathophysiology at Northwest Community College, Selkirk College and Okanagan College/Okanagan University College – which is now UBC Okanagan. She currently teaches first year biology and upper level developmental biology. Her research is focused on how critical thinking skills affects students’ ability to learn difficult scientific concepts and their success in university in general. Blythe is also the National Science Chair and member of the board for Centre for Inquiry Canada, a national organization that promotes and advances reason, science, secularism and freedom of inquiry in all areas of human endeavour. She writes a monthly column titled “Okanagan Skeptic” in the Kelowna Daily Courier.