He received his PhD in Integrative Biology doing research in the PolyPEDAL Lab at the University of California at Berkeley, and did his postdoctoral work in the GRASP Laboratory of the University of Pennsylvania. Prior to his academic work, Shai was Chief Architect R&D of the convergent systems division of Harmonic Lightwaves (HLIT), and a co-founder of Bio-Systems Analysis, a biomedical technology start-up.