Her health disparities research involves community-based health communication studies, and the role of culture in health cognitions and behaviors. Dr. Holt’s research program has generated over $11.5 million in extramural support as Principal Investigator, from sources such as the NIH, CDC, and ACS. The program has resulted in over 50 peer-reviewed publications, most including student co-authors. Specifically, Dr. Holt’s research examines religious involvement and health among African Americans, and using religion/spirituality to frame breast, prostate, and colon cancer early detection messages for this population. More recently her intervention work has added a behavioral translational research focus.