Fisher graduated from Vanderbilt University School of Medicine in 1996 and completed her training in internal medicine at the University of Virginia followed by a gastroenterology fellowship at Duke. Since joining the faculty in 2002, Fisher has conducted health services and outcomes research in gastroenterology, including colorectal cancer screening/surveillance, gastrointestinal bleeding, and biliary obstruction. She is also an expert in quality measurement and has served on a number of national clinical guidelines committees.