Her research interest is in control engineering and physiological systems, being leader of the Modeling and Control in Anesthesia and Biomedical Systems Research Group. She has co-authored more than 150 scientific papers and organized several special sessions at international conferences. Since 2005, Dr. Mendonca has supervised (or co-supervised) 10 PhD students. She is member of the IEEE SMC, the IEEE-CSS TCs on Systems Identification and Adaptive Control, and IEEE CSS TC on Medical and Healthcare Systems, and the IFAC TC on Biological and Medical Systems.