She is the Director of the Interactive Simulation (iSim) Laboratory where she uses virtual reality technologies and applied neuroscience approaches to study human performance and brain function within natural and simulated environments. The lab employs the use of neurosensing devices such as near infrared imaging and electroencephalography to capture both temporal and spatial aspects of brain activity while persons perform real world tasks. Cali's expertise also includes integrating psychophysiological measures such as eye tracking within simulation based training systems to create novel perceptual user interfaces. Her current work combines the understanding of head-mounted displays, neuroscience techniques, computer graphics, and user perception to create optimal virtual environment training solutions for military, surgical, and rehabilitation applications.