Below he discusses some of current work of his lab. In many instances, human pathology can be directly tied to the proteins that reside out the outside, on the surface, and within human cells. This in itself should not be surprising. After all, proteins are well established as acting as the workhorses of cells. Not only are proteins responsible for a high volume of chemical transformation that need to take place for cells to remain viable, they also have a series of additional roles in structuring biomacromolecules, inter- and intra-cellular communication, and storage. Through all these functions, diversity within the protein matrix becomes essential. After all, there are only 20-22k genes that encode human proteins in the human genome. The question that naturally arises is: how do human cells perform all the necessary and incredibly diverse tasks with such a limited set of building block?