He received his PhD in 2002. His group focuses on the pathogenic role of amyloid plaques and associated neuronal dystrophy, especially the non-fibrillar amyloid-beta (Aβ) assemblies, also called Aβ oligomers, that may represent the bioactive molecules involved in the physiopathology of Alzheimer’s disease-related neuronal dysfunction and memory impairment. The Lesne laboratory is examining whether and how Aβ oligomers can interact at neuronal plasma membranes with specific receptors involved in the cellular form of memory by combining biochemical and functional assays.