He is also the Chief of Breast Medical Oncology and Director of Clinical Research for the Susan F. Smith Center for Women’s Cancers at Dana-Farber Cancer Institute. Dr. Krop is a clinical translational medical oncologist whose primary research focuses on understanding and overcoming mechanisms of resistance to HER2-directed therapies. Dr. Krop played a major role in developing T-DM1 (KADCYLA® or ado-trastuzumab emtansine), a new therapy for HER2-positive breast cancers, including metastatic breast cancer. Dr. Krop is currently leading several clinical trials exploring combinations of novel targeted therapies designed to overcome resistance to HER2-directed agents. Dr. Krop’s Komen-funded research supports a project that seeks to understand how breast tumors and metastatic tumors from breast cancer patients become resistant to HER2-targeted therapies.