Most recently, Milbrandt was on the faculty of the University of Illinois College of Medicine and OSF Medical Group in Peoria (2002-05), where she also completed her pediatrics residency and earned her medical degree (2002, 1999). She earned her bachelor's degree at Illinois Wesleyan University in Bloomington (1994). She is board certified as a diplomate by the American Board of Pediatrics and fellow of the American Academy of Pediatrics. A native of Springfield, Milbrandt is married to Joseph Milbrandt and has three children.