While going over potential cases, he suffers a devastating car crash that crushes both of his hands. Losing his ability to practice medicine crushes his soul and he lashes out at the person who loves him the most, Dr. Catherine Palmer. He is out of money and down on his luck, when his physical therapist tells Dr. Strange about a paraplegic man, Jonathan Pangborn, that gained the ability to walk. Dr. Strange finds Jonathan (whom Dr. Strange turned down to help after his injury), and learns that Jonathan went to Nepal and go help at Kamar-Taj. Dr. Strange is quickly on his way to find his destiny, strength, and purpose. But will he have to sacrifice his oath as a doctor, to save all of humanity? It will take a cosmic astrophysical, mirror shattering, and mind bending trip to find out.