His laboratory specializes in the rational design of nanoparticles for oxygen delivery. As a researcher in the Translational Research Program (TRP) at Boston Children's Hospital, Dr Polizzotti is actively involved in the development of non-clinical and human clinical trials that seek to improve the care of children, and to ensure adequate infrastructure to support non-clinical and clinical translational research projects. His recent work in Science Translational Medicine, for example, has shown that the optimal window of time to stimulate heart muscle cell regeneration (cardiomyocyte proliferation) in humans is the first six months of life and that that early administration of neuregulin may provide a targeted and multipronged approach to prevent heart failure in infants with CHD.