He has a longstanding interest in how stem cells make cell fate decisions during embryonic development by coordinating their intrinsic genetic program with cues from their surrounding microenvironment. The goal of the Mack laboratory is to apply their understanding of this basic question to the development of stem cell and gene therapy treatments for neuromuscular diseases. David’s expertise is rooted at the intersection of genetics, developmental biology, cancer biology, and biomaterials, which resulted directly from different phases of his professional training.