Madias joined the faculty of Rush University in 2010 following a faculty appointment at San Diego Medical Center-Kaiser Permanente and Scripps Memorial Hospital of La Jolla, California. He earned his Bachelor of Science (cum laude) and medical degrees from Tufts University in Boston, Mass., where he was elected to the Alpha Omega Alpha Honor Medical Society. His training includes an internal medicine residency at New York Presbyterian-Weill Cornell Medical Center of New York, NY. He completed his fellowships in cardiovascular disease and clinical cardiac electrophysiology at Tufts Medical Center in Boston, where he was appointed chief cardiology fellow.