Her research is highly interdisciplinary; combining protein engineering and chemical biology approaches with computational biology to study the spatiotemporal dynamics of protein signaling networks that drive cellular behavior. Her research group is developing selective protein tagging and protein-surface conjugation methods that are coupled with nanotechnologies and other emergent techniques to rapidly characterize protein function. Computational work includes the development of deterministic and stochastic simulations of protein signaling in small cellular compartments. These techniques are applied to the study of Ca2+-dependent protein signaling that underlie learning and memory.