Her focus was on maternal and women’s health especially antenatal primary care. Nontuthuzelo was also a nurse educator for Eastern Cape nursing students and was also involved with research in sexual and reproductive health at the Women’s Health Research Unit at the University of Cape Town. Nontuthuzelo also worked with the Planned Parenthood Association of South Africa (PPFSA) in sexual and reproductive health, supporting NGOs who provide related services. She started working for Kheth’Impilo as a manager overseeing community adherence worker training and she now manages the Community Services Cluster in her current capacity.