She graduated from Case Western Reserve University School of Medicine and completed her residency at Martin Luther King Jr./C.R. Drew Medical Center, where she currently is Director of its Breast Clinic. Dr. Clayton is a Fellow of the American College of Surgeons and is a member of several professional societies, including the National Medical Association, the Association of Black Women Physicians, the Los Angeles Surgical Society, and the American Society of Bariatric Surgeons. She serves on the CAP and MPT Audit, Compensation, and Finance committees. Dr. Clayton became a CAP member in 1990.