His group investigates the molecular and cellular origins of human epithelial malignancies (e.g., breast cancer, Barrett’s) through two interrelated approaches: (a) computational pathology and bioimaging, where they develop algorithms to analyze intratumor phenotypic heterogeneity from in situ fluorescent imaging of tissue sections or tissue microarrays and (b) computational biophysics, where they develop models based on anharmonic fluctuations to discern short-lived and rare intermediate conformations that proteins access to fold, bind, and function.