He received his MD from UMDMJ-Rutgers Medical School (Robert Woods Johnson Medical School); he completed his medicine residency at Michael Reese Medical Center and gastroenterology fellowship at Northwestern Medical Center. DeMeo's clinical practice focuses on celiac disease, immune mediated functional disease, and the effect of food intolerances on the GI tract. His research focuses on his clinical interests. He is the director of the Celiac Disease Clinic at Rush. ​