potency the drug may be dosed once per week and achieve a similar effect as if given daily application_number US 65627300 A description the prior art for example u s pat no 5 552 421 teaches that lasofoxifene and related compounds should be administered frequently in small doses doses as low as 0 1 mg four times per day are suggested for human patients we have now unexpectedly found that a single dose of 0 8 mg of lasofoxifene administered to healthy women resulted in an initial blood level of 0 7 ng ml within a few hours levels declined slowly thereafter to a concentration of about 0 3 ng ml after 168 hours 1 week 0 3 ng ml is considered to be a therapeutic effective dose doses from 10 to 20 mg of lasofoxifene are acceptable such a dose would provide a therapeutically effective dose for up to 30 days see table 2 a dose of 0 8 mg of lasofoxifene was administered to 12 healthy postmenopausal women and blood samples were analyzed periodically as shown in table 1 a 1 0 ml sample of human plasma was analyzed for lasofoxifene according to cedra 39 s procedure tm 234 cedra 39 s address internal standard used for this procedure was a pentadeuterated lasofoxifene the plasma sample containing lasofoxifene and the internal standard was extracted with.