7 cycloalkyl in certain embodiments of the compound of formula i r 4 is h u2014 c o u2014 r a wherein r a is hydroxy or c 1 7 alkoxy u2014 c o u2014 nr b r c wherein r b and r c are each independently h c 1 7 alkyl optionally substituted with one or more halo hydroxy or cyano u2014 ch 2 z u2014 c 3 7 cycloalkyl optionally substituted by one or more b and z is 0 1 2 3 or 4 preferably 0 or 1 u2014 ch 2 y heterocyclyl wherein y is 0 1 2 3 or 4 preferably 0 and wherein heterocyclyl is tetrahydropyranyl optionally substituted by one or more a or r 3 and r 4 together form an annelated benzo ring the benzo ring is optionally substituted by one or more e a is hydroxy oxo c 1 7 alkyl c 1 7 alkoxy c 1 7 haloalkyl c 1 7 hydroxyalkyl halo or cn b is halo hydroxy cn c 1 4 alkyl or c 1 4 haloalkyl e is halo cn no 2 hydroxy c 1 7 alkyl c 1 7 alkoxy c 1 7 haloalkyl c 1 7 hydroxyalkyl c 1 7 cyanoalkyl c 1 7 haloalkoxy or c 3 7 cycloalkyl x is o or nh r 1 is phenyl optionally substituted with one two or three halo r 2 is h c 1 4 alkyl or c 1 4 haloalkyl preferably h methyl or trifluoromethyl r 3 is h r 4 is h u2014 c o u2014 r a wherein r a is hydroxy c 1 7 alkoxy c 1 7 alkyl phenoxy or phenyl u2014 c o u2014 nr b r c wherein r b and r c are each.