thirteen year old shihtzu dog with imha with prednisolone and leflunomide and probiotics p acidilactici and s boulardii fig2 a shows the pcv over a 9 month period from september 2009 to june 2010 after an abrupt drop at the beginning of the study the pcv level began a substantial raise beginning january 2010 5 months into the study fig2 b shows the daily treatments of the dog over the period in fig2 a the steroid prednisolone was initially administered at 2 mg kg day which was reduced to 1 mg kg day after 6 months and to 0 75 mg kg day from months 8 to 9 leflunomide was administered at 2 5 mg kg day from the beginning for 7 months when the drug was administered at 2 5 mg kg day but administered every other day for two additional month the probiotic mitomaxsuper u2122 was administrated at one capsule one billion live microorganisms per day for the period from 4 months through the end of the study at 9 months comparison of fig2 a and 2b show that the decline in pcv associated with imha was stabilized by the combination treatment with prednisolone and leflunomide the probiotic mitomaxsuper u2122 was added one month before reduction and prednisolone and leflunomide and probiotic therapy was continued to the end of the study reduction of administration of prednisolone and cyclosporine while maintaining the level of.