the structure is provided this stability is maintained in the presence of water or simulated digestive juices in view of the thermoplastic behavior which is present at a high temperature the method of melt extrusion may be used for making the mixture 2 5 g of an isdn lactose mixture consisting of 40 isdn and 60 lactose were dry mixed with 0 7 sifted off fine component of polyvinylacetate commercial type vinapas b 5 spezial and 0 6 g highly dispersed silicon dioxide aerosil 200 were sifted through a tea sifter heated in a drying oven to about 80 u00b0 c and kneaded with the pestle until a homogenic uniformly wetted through viscous mass was generated during the cooling off a trace of isdn lactose mixture 40 60 was scattered over it for seeding and kneaded with the pestle the crystallisation during kneading reulted to a solid material in a short time which slowly further hardened it behaved somewhat plastic but also did easily break small pieces were rolled out into thin strands on a heated metal plate at 40 u00b0 to 50 u00b0 c and were cut into small pieces after hardening next day the pieces were fed through a 1 mm sieve the fine component was sifted off with the tea sieve table i shows the in vitro active substance release of nonpressed.