or u201c ameliorating u201d are used interchangeably herein these terms refers to an approach for obtaining beneficial or desired results including but not limited to therapeutic benefit and or a prophylactic benefit by therapeutic benefit is meant eradication or amelioration of the underlying disorder being treated also a therapeutic benefit is achieved with the eradication or amelioration of one or more of the physiological systems associated with the underlying disorder such that an improvement is observed in the patient notwithstanding that the patient may still be afflicted with the underlying disorder for prophylactic benefit the compositions may be administered to a patient at risk of developing a particular disease or to a patient reporting one or more of the physiological systems of a disease even though a diagnosis of this disease may not have been made terminology related to u201c protecting u201d u201c deprotecting u201d and u201c protected u201d functionalities occurs throughout this application such terminology is well understood by persons of skill in the art and is used in the context of processes that involve sequential treatment with a series of reagents in that context a protecting group refers to a group which is used to mask a functionality during a process step in which it would otherwise react but in which reaction is undesirable the protecting group prevents reaction at that step but may be subsequently removed to expose the.