skellysolve b mp 83 u00b0 85 5 u00b0 c anal calcd for c 10 h 10 n 2 o 2 c 63 14 h 5 30 n 14 73 found c 63 42 h 5 39 n 14 86 the general procedure of example 2 was repeated except that two equivalents of tert butylamine utilized therein were replaced with one equivalent of cyclopropylamine and one equivalent of diisopropylethylamine the crude product was purified by flash chromatography using methylene chloride followed by methylene chloride methanol 98 2 and then recrystallized from ethyl acetate skellysolve b to yield the title compound mp 102 u00b0 105 u00b0 c anal calcd for c 10 h 12 n 2 o 2 c 62 48 h 6 29 n 14 58 found c 62 19 h 6 36 n 14 55 a solution of 5 cyclopropylisoxazole 4 carbonyl chloride 7 9 g 46 mmoles prepared in example 1 step d in methylene chloride was treated dropwise at 0 u00b0 c with 3 trifluoromethylaniline 14 8 g 92 mmoles the resultant paste was stirred at ambient temperature for two hours and partitioned between more methylene chloride 10 hcl and ethyl acetate the organic layer was separated dried and evaporated the solid residue was placed on silica gel and chromatographed using ether skellysolve b 1 1 recrystallization of the product from ether skellysolve b yielded 3 17 g 23 of the title compound mp 108 5 u00b0 111 u00b0 c anal calcd for c 14 h 11 f 3 n 2 o 2 c 56 75 h 3 74 n 9 46 found c 56 75 h 3 73 n 9 47 a solution of p anisidine 10 1 g 81 4 mmoles in 100 ml of methylene chloride was added at 0.