rather than 5 membered ring heterocycles as reagents as in the embodiments described above the cyclic sulfate described above is opened in the coupling reaction due to nucleophilic attack of the heteroatoms i e x u2550 s se n on the ring sugars as will be apparent to a person skilled in the art the general formulas for the 6 membered sugar reagent and resulting target compound are as shown below the 6 membered ring target compound shares the same internal salt structure as the 5 membered ring embodiment the substituent groups may vary as described above without departing from the invention the following examples will further illustrate the invention in greater detail although it will be appreciated that the invention is not limited to the specific examples optical rotations were measured at 20 u00b0 c 1 h and 13 c nmr spectra were recorded at 400 13 and 100 6 mhz for proton and carbon respectively all assignments were confirmed with the aid of two dimensional 1 h 1 h cosydftp or 1 h 13 c invbtp experiments using standard bruker pulse programs maldi tof mass spectra were obtained for samples dispersed in a 2 5 dihydroxybenzoic acid matrix using a perseptive biosystems voyager de instrument silica gel for chromatography was merck kieselgel 60 high resolution mass spectra were lsims fab run.