tooth paste according to the present invention is prepared by a conventional method the gelating and wetting agents are mixed first to the resulting gel like mass all other components of the paste are added to ensure a long time storage of the paste a preservative such as sodium benzoate is added thereto to prevent stratification of the paste like mass it is added with a buffer solution with a ph of 8 10 and silica with a particle size of 5 20 nm and the content of sio 2 of 99 8 after the addition of each component the mixture is thoroughly agitated to obtain a uniform paste which is milled and packed the anticarious substance incorporated in the composition of the tooth paste according to the present invention is obtained in the following manner a bone tissue is covered with a diluted mineral acid and kept therein under stirring until complete dissolution of mineral components and water soluble proteins contained in the bone tissue occurred then the resulting solution is separated and diluted with water with the addition of a stabilizing agent citric acid or salts thereof thereafter the solution is neutralized to facilitate transportation and storage of the substance it is obtained in the dry form to this end the solution is sprayed in a drier the obtained product is a white amourphous powder having no odour with a slightly salty taste readily soluble in water sparingly soluble in 95 alcohol substantially insoluble.