limited by theory the invention disclosed teaches methods of utilizing the immune response of a cancer patient in a therapeutic manner to control tumor recurrence and or metastasis subsequent to a procedure during which tumor antigens are released numerous procedures are clinically used that are associated with release of tumor antigens especially attractive procedures to which this invention is tailored are procedures associated with induction of tumor cell necrosis in a localized microenvironment specifically therapies such as transcatheter chemoembolization tace conformal radiotherapy percutaneous ethanol administration embolization therapy localized hyperthermia and electromagnetic ablation therapy one specific embodiment of the invention involves modification of the tace procedure in order to induce a systemic anti tumor immunological effect specifically patients are selected to meet the criteria for tace said criteria includes a adequate hepatic function b patent portal vein circulation confirmed during the venous phase of celiac or superior mesenteric angiogram and c adequate renal function generally only patients without cirrhosis or in child group a or b disease are considered however depending on experience of the practicing physician other groups may be included in the procedure as discussed by shah et al shah et al 1998 qjm 91 821 828 which is incorporated by reference herein in its entirety the tace procedure may be performed either using a selective or superselective means patients selected to undergo the procedure receive 10 mg of phytonadione intravenously prior to the procedure the intravenous.