in combination therapy the type of pharmaceutical formulation of the first and second active ingredient of a combination or kit of parts according to this invention can be similar i e both ingredients are formulated in separate tablets or capsules or can be different i e suited for different administration forms such as e g one active ingredient is formulated as tablet or capsule and the other is formulated for e g intravenous administration the amounts of the first and second active ingredients of the combinations compositions or kits according to this invention may together comprise a therapeutically effective amount for the treatment prophylaxis or amelioration of a disease responsive or sensitive the inhibition of histone deacetylases in particular responsive or sensitive to the selective inhibition of hdac6 particularly one of those diseases mentioned herein in addition compounds according to the present invention can be used in the pre or post surgical treatment of cancer in further addition compounds according to the present invention can be used in combination with radiation therapy in particular in sensitization of cancer patients towards standard radiation therapy a combination according to this invention can refer to a composition comprising both the compound s according to this invention and the other active anti cancer agent s in a fixed combination fixed unit dosage form or a medicament pack comprising the two or more active ingredients as discrete separate dosage forms non fixed combination in case of a medicament pack comprising the two or more active ingredients the active ingredients are preferably packed into blister cards which are suited for improving compliance each blister card preferably contains the medicaments.