range from about 0 4 mg to about 3000 mg per treatment in more specific embodiments the range is from about 4 to 1500 mg or from about 8 to 600 mg or most specifically from about 40 to 300 mg per treatment treatment typically is administered once daily effective doses will also vary as recognized by those skilled in the art depending on the diseases treated the severity of the disease the route of administration the sex age and general health condition of the patient excipient usage the possibility of co usage with other therapeutic treatments such as use of other agents and the judgment of the treating physician for example guidance for selecting an effective dose can be determined by reference to the prescribing information for safinamide for pharmaceutical compositions that comprise a second therapeutic agent an effective amount of the second therapeutic agent is between about 20 and 100 of the dosage normally utilized in a monotherapy regime using just that agent preferably an effective amount is between about 70 and 100 of the normal monotherapeutic dose the normal monotherapeutic dosages of these second therapeutic agents are well known in the art see e g wells et al eds pharmacotherapy handbook 2nd edition appleton and lange stamford conn 2000 pdr pharmacopoeia tarascon pocket pharmacopoeia 2000 deluxe edition tarascon publishing loma linda calif 2000 each of which references are incorporated herein by.