afford ketone 11 str10 in an alternate route to 9 as shown in scheme iii 2 alkylsubstituted 6 iodo 4 lh quinazolinone 12 prepared by scheme i is reacted via a palladium catalyzed formylation str11 as shown in scheme iv the palladium ii catalyzed coupling of trimethylsilyl acetylene with 2 alkylsubstituted 6 iodo 4 lh quinazolinone 12 yields the acetylenic quinazolinone 13 desilylation of the acetylene with sodium hydroxide in water methanol gives the terminal acetylene 14 hydration of acetylene 14 with catalytic mercuric sulfate sulfuric acid in acetic acid affords methyl ketone 15 the palladium ii catalyzed coupling of substituted acetylenes where r 17 is defined as straight or branched lower alkyl of 1 to 30 it 4 carbon atoms with 2 alkylsubstituted 6 iodo 4 lh quinazolinone 12 yields the acetylenic quinazolinone 16 hydration of 1 6 with catalytic mercuric sulfate sulfuric acid in acetic acid gives ketone 17 str12 in addition as shown in scheme v acetylene 14 is hydrogenated over 5 palladium barium sulfate in pyridine to give either the terminal olefin 18 or the ethyl substituted quinazolinone 19 also acetylene 16 is hydrogenated over 5 palladium barium sulfate in pyridine to give olefin 20 and alkyl substituted quinazolinone.