
{"publication_number": "US-4859590-A", "abstract": "\u03b1 - glucosyl fluoride can be converted in the presence of cyclodextrin \u03b1glucosyltransferase into a mixture of \u03b1 - and \u03b2 - cyclodextrins in high yield .", "application_number": "US-8008687-A", "description": "cyclodextrins are well known as products of the reaction of starch with cyclodextrin \u03b1 ( 1 \u2192 4 ) glucosyltransferase ( e . c . 2 . 4 . 1 . 19 ) from bacillus macerans . t . ogawa and y . takahashi , carbohydr . res . 138 , c5 ( 1985 ) recently succeeded with the first , complicated , chemical synthesis of \u03b1 - cyclodextrin . cyclodextrins are capable of forming inclusion complexes with a large number of physiologically active substances and therefore demand particular interest in pharmaceuticals research ( m . l . bender and m . komiyama : &# 34 ; cyclodextrin chemistry &# 34 ;, springer verlag , berlin 1978 ). the following reactions which are catalyzed by cyclodextrin glucosyltransferase ( cgt ) are known hitherto [ h . bender , carbohydr . res . 78 , 133 ( 1980 ); k . wallenfels et al ., carbohydr . res . 61 , 359 ( 1978 ); h . bender , carbohydr . res . 78 , 147 ( 1980 )]: ## str1 ## in some studies , it was possible to show that certain enzymes in carbohydrate chemistry accept glucosyl fluorides as substrates for their reaction [ p . j . card and w . d . hitz , j . am . chem . soc . 106 , 5348 ( 198 ); d . g . drueck - hammer and c .- h . wong , j . org . chem . 50 , 5912 ( 1985 ); a . m . gold and m . p . osber , biochem . biophys . res . commun . 42 , 469 ( 1971 )]. surprisingly , it has been found that the enzyme cyclodextrin glucosyltransferase {( 1 \u2192 4 )- \u03b1 - d - glucan : [( 1 \u2192 4 )- \u03b1 - d - glucopyranosyl ] transferase ( cyclizing ), e . c . 2 . 4 . 1 . 19 , cgt 