u00b1 0 38 12 rats 4 7 17 u00b1 0 47ee sub 2 group 2 0 00 u00b1 0 00 6 rats 4 1 50 u00b1 0 00 compound a 2 1 35 u00b1 0 87 group 6 rats 4 2 12 u00b1 1 00 ______________________________________ p u2266 0 05 vs cdx control ovariectomized or sham surgeried rats are group housed in metal wire hanging cages immediately following surgery animals are given either control vehicle 1 5 carboxymethylcellulose ethynyl estradiol 0 1 mg kg or a compound of formula 1 0 01 to 10 mg kg by daily oral gavage the animals have ad lib access to food and water body weight is determined after 35 days of dosing ______________________________________ body weightgroup change g sup a______________________________________intact control 77 4 u00b1 3 1 ovx control 120 3 u00b1 3 8ovx ee sub 2 18 0 u00b1 4 0 0 1 mg kg ovx ral 108 6 u00b1 4 0 0 01 mg kg ovx ral 70 5 u00b1 3 7 0 1 mg kg ovx ral 62 2 u00b1 3 0 1 mg kg ovx ral 53 7 u00b1 2 8 10 mg kg ______________________________________ sup a mean body weight u00b1 sem for for 28 intact control 29 ovx control 12 ee sub 2 or 30 each raloxifene dose rats per group p u2266 0 05 vs ovx control by scheffe range test nocturnal 12 hr feeding and daytime feeding induced by insulin 10 mg kg is also assessed.