a paquette john wiley amp sons chichester 1995 pp 3345 u2013 3347 and s burckhardt synlett 2000 559 also for some additional primary literature see burgess e m penton h r taylor e a j am chem soc 1970 92 5224 u2013 5226 wood m r kim j y books k m tetrahedron lett 2002 43 3887 u2013 3890 to demonstrate this teaching the methodology was employed using a representative set of commercially available secondary u03b2 amino alcohols exposure of all substrates listed in fig2 to excess burgess reagent 1 in refluxing thf for 8 hours led to the formation of the desired cyclic sulfamide product in high yield regardless of the nature of the group attached onto the amine of particular note neither placing the amine in a hindered cyclic setting entry 4 nor adding a bulky t butyl substituent entry 3 retarded product formation this latter substrate constitutes a particularly effective test for the power of this synthetic technology as starting materials bearing this functionality have in general proven recalcitrant to sulfamide formation with currently available methods castro j l et al j med chem 1994 37 3023 u2013 3032 of equal importance all aniline derived systems entries 5 u2013 8 proved readily amenable to the cyclization process regardless of the electron withdrawing entries 6 and 7 or donating entry 8 properties of the appended aromatic ring these results are particularly indicative of the broad.