any suitable route the dosage of the individual agents of the combination may require more frequent administration of one of the agent s as compared to the other agent s in the combination therefore to permit appropriate dosing packaged pharmaceutical products may contain one or more dosage forms that contain the combination of agents and one or more dosage forms that contain one of the combination of agents but not the other agent s of the combination the term u201c single formulation u201d as used herein refers to a single carrier or vehicle formulated to deliver effective amounts of both therapeutic agents to a patient the single vehicle is designed to deliver an effective amount of each of the agents along with any pharmaceutically acceptable carriers or excipients in some embodiments the vehicle is a tablet capsule pill or a patch in other embodiments the vehicle is a solution or a suspension the term u201c unit dose u201d is used herein to mean simultaneous administration of both agents together in one dosage form to the patient being treated in some embodiments the unit dose is a single formulation in certain embodiments the unit dose includes one or more vehicles such that each vehicle includes an effective amount of at least one of the agents along with pharmaceutically acceptable carriers and excipients in some embodiments the unit dose is one or more tablets capsules pills or patches administered to the patient at the same time the term u201c treat u201d is used herein to mean to relieve reduce or alleviate at least one symptom of a disease in a subject within the meaning of the present invention the term u201c treat u201d.