scheme 9 below shows a method for synthesizing dithiazolylbiphenyl 119a a stereoisomer of dithiazolylbiphenyl 5a scheme 10 shown below illustrates synthesizing dithiazolylbiphenyl peptides 6a 120a 121a and 122a from compound 5a and 119a via peptide coupling conditions e g hobt h 2 o and edc these dithiazolylbiphenyl peptides are deprotected and subsequently reacted with various alkyl or aryl acetyl chlorides to produce desired compounds 7a and 123a 127a schemes 11 13 below show typical synthetic routes to multicyclic compounds of this invention aryl bromides e g 12a u02dc c 16a u02dc c or 21a u02dc c above are reacted with arylboronic esters e g 13a u02dc c 20a u02dc c or 22a u02dc c above under suzuki miayura coupling conditions to construct the n protected asymmetric biphenyl compounds 23a u02dc c as shown in schemes 7 9 n deprotection of pyrrolidine moieties in trifluoroacetic acid at room temperature yield n deprotected derivatives 24a u02dc c which are then coupled with n boc d phenylglycine to afford the asymmetric biphenyl compounds 25a u02dc c in one step fashion 25a u02dc c can be treated with trifluoroacetic acid and then be reacted with various alkyl or aryl acetyl chlorides to give the final acylated products 26a u02dc c similarly other substituted compounds e g 30a u02dc c 34a u02dc c 38a u02dc c 42a u02dc c and 46a u02dc c shown in schemes 11 13 below can be prepared the compounds of this invention can also be synthesized in manners similar to those outlined in schemes 1 13 with necessary modifications as recognized by those skilled in the art compounds thus synthesized can be further purified by flash column chromatography high performance liquid chromatography crystallization or any other suitable methods the compounds mentioned herein contain.