142 5 91 2 12 141 7 107 2 4 188 0 76 3 9 123 4 74 3 0 2964 change 12 u2212 10 24 u2212 54 0 151 3 0 0135 12 u2212 81 8 209 6 4 u2212 52 0 34 7 8 u2212 13 4 49 7 0 2320 wilcoxon signed rank test kruskal wallis exact test dose level defined using the last actual dose during study 8 effect in healthy young and old male and female volunteers eight young 19 40 years of age and eight old 65 years of age and older healthy volunteer male and female subjects received 2 325 grams of renagel u00ae binder epichlorohydrin cross linked polyallylamine three times per day with meals for 32 days all drug doses were administered with meals served at a clinical research center for the entire 32 day study on day 0 a 10 ml blood sample was drawn prior to the morning meal and analyzed for plasma cholesterol levels on day 32 a second 10 ml blood sample was drawn prior to the morning meal subjects were released from the study after the morning meal on day 32 plasma triglycerides and hdl were measured.