a few seconds to several minutes and rarely for an hour 1 mild sensation of heat without sweating 2 moderate sensation of heat with sweating able to continue activity 3 severe sensation of heat with sweating causing cessation of activity waking episodes i e episodes that wake the subject from sleep associated with hot flushes were recorded separately and were considered severe the primary efficacy variables were the number and severity of hot flushes the measurements of the qol questionnaires were considered secondary evaluations the sleep disruption scale profile of mood states and menopause specific quality of life questionnaires were administered at every visit starting at visit 2 the pittsburgh sleep quality index and short form 36 health survey were administered at all double blind treatment phase visits except visit 3 at the final study visit each subject provided an overall evaluation of study treatment by completing a subject global assessment the rating scale for the final assessment by the subject included much better better slightly better no meaningful difference slightly worse worse or much worse the results of the study are shown in tables 1 and 2 and fig1 and 2 table 1 shows the reduction in frequency of hot.