for example avicel u00ae fmc corp or emcocel u00ae mendell inc dicalcium phosphate for example emcompress u00ae mendell inc calcium sulfate for example compactrol u00ae mendell inc and starches for example starch 1500 additionally one can add a disintegrating agent such as microcrystalline cellulose starches crospovidone for example polyplasdone xl u00ae international specialty products sodium starch glycolate for example explotab u00ae mendell inc and croscarmellose sodium for example ac di sol u00ae fmc corp antiadherants and glidants employed herein can include talc cornstarch silicon dioxide sodium lauryl sulfate colloidal silica dioxide and metallic stearates lubricants may be employed such as magnesium stearate calcium stearate sodium stearate stearic acid sodium stearyl fumarate sterotex talc waxes and the like binding agents may be employed such as polyvinyl pyrollidone starch methylcellulose hydroxypropyl methylcellulose carboxymethyl cellulose and the like the present invention is preferably formulated into a tablet prepared using methods known in the art including a wet granulation method and a direct compression method the oral tablets are prepared using any suitable process known to the art see for example remington 39 s pharmaceutical sciences 18 th edition a gennaro ed mack pub co easton pa 1990 chapters 88 91 the entirety of which is hereby incorporated by reference typically the active ingredient doxycycline is mixed with pharmaceutically acceptable excipients e g the binders lubricants etc listed above and compressed into tablets preferably the dosage form is prepared by a wet granulation technique or a direct compression method to form uniform granulates alternatively the active ingredient s can be mixed with the granulate after the granulate is prepared the moist granulated mass is then dried and sized using a suitable screening device to provide a powder which can then be filled into capsules or compressed into matrix tablets or caplets as.