reacted with excess dihydropyran in methylene chloride in the presence of pyridine hydrochloride at about 25 u00b0 c for 6 hr the reaction mixture is washed with aqueous potassium bicarbonate solution dried and concentrated ii the formula xxxv selenide derivative is next prepared to a solution of n isopropylcyclohexylamine 8 27 mmol in 30 ml of tetrahydrofuran at 78 u00b0 under nitrogen is added n butyllithium 4 7 ml 7 52 mmol 1 6 in hexane via syringe the mixture is stirred for 15 min and to it is added the product of step i above 3 76 mmol in 10 ml of tetrahydrofuran and stirring is continued at 78 u00b0 c for an additional 30 min diphenyl diselenide 5 64 mmol in 15 ml of tetrahydrofuran is then added to the reaction mixture after stirring at 78 u00b0 for an additional hour the dry ice bath is removed and the reaction mixture allowed to warm up to 0 u00b0 the resulting mixture is poured into 150 ml of saturated aqueous ammonium chloride and 150 ml of ether the ether layer is separated and the aqueous layer extracted with ether 800 ml total the combined ether extracts are washed successively with 40 ml of ice water and 30 ml of saturated brine the organic extract is dried over na 2 so 4 and concentrated in vacuo to yield crude 2 phenyl selenide derivative iii the formula xxxvi u03b4 2 compound is next prepared a solution of the selenide derivative of part ii above 2 88 mmol in 65 ml of methylene chloride is treated at about 25 u00b0 c with hydrogen peroxide 29 mmol as a 10 aqueous.