hydrox 2 methyl 3 propionic acid the present invention further discloses micronized rac bicalutamide and the preparation thereof application_number US 17072102 A description as used herein rac bicalutamide refers to both the r u2212 enantiomer and s enantiomer of bicalutamide rac bicalutamide is the racemic and optically pure r u2212 and s isomers of n 4 cyano 3 trifluoromethyl phenyl 3 4 fluorophenyl sulfonyl 2 hydroxy 2 methyl propionamide it is to be understood that this invention encompasses the racemic form of bicalutamide and any optically active form which possesses anti androgenic activity it is a matter of common general knowledge how a racemic compound may be resolved into its optically active forms and how any anti androgenic activity present in any of these forms may be determined one skilled in the art will appreciate that the separation of optical isomers can be achieved by conventional resolution such as fractional crystallization or flash chromatography as used herein the term u201c micronized u201d refers to particles having a mean particle diameter of less than about 200 u03bcm as used herein the term u201c u03bcm u201d refers to u201c micrometer u201d which is 1 u00d7 10 u2212 6 meter the following abbreviations are used herein dcm is dichloromethane thf is tetrahydrofuran dabco is 1 4 dizazbicyl 2 2 2 octane acb is 5 amino 2 cyano benzotrofluoride bcl is rac bicalutamide 4 fpms is 4 fluorophenyl methyl sulfone the present invention provides.