and leiomyosarcoma gastrointestinal autonomic nerve tumor malabsorption syndromes celiac diseases diverticulosis meckel 39 s diverticulurn colonic diverticula megacolon hirschsprung 39 s disease irritable bowel syndrome mesenteric ischemia ischemic colitis colorectal cancer colonic polyposis polyp syndrome intestinal adenocarcinoma liddle syndrome brody myopathy infantile convulsions and choreoathetosis the peptides can be conjugated to another molecule e g a diagnostic or therapeutic molecule to target cells bearing the gcc receptor e g cystic fibrosis lesions and specific cells lining the intestinal tract thus they can be used to target radioactive moieties or therapeutic moieties to the intestine to aid in imaging and diagnosing or treating colorectal metastasized or local colorectal cancer and to deliver normal copies of the p53 tumor suppressor gene to the intestinal tract the peptides can be used alone or in combination therapy to treat erectile dysfunction the peptides can be used alone or in combination therapy to treat inner ear disorders e g to treat meniere 39 s disease including symptoms of the disease such as vertigo hearing loss tinnitus sensation of fullness in the ear and to maintain fluid homeostasis in the inner ear the peptides can be used alone or in combination therapy to treat disorders associated with fluid and sodium retention e g diseases of the electrolyte water electrolyte transport system within the kidney gut and urogenital system congestive heart failure hypertension hypotension liver cirrhosis and nephrotic syndrome in addition they can be used to facilitate diuresis or control intestinal fluid the peptides can be used alone or in combination therapy to treat disorders associated with chloride.