p after one week rats with marked hyperglycemia fasting blood glucose gt 300 mg dl were used as the diabetic rats test materials were four different extracts as dry powders of bitter melon of a wild genotype or metformin extracts 1 4 were produced and preserved via different methods attempting to retain efficacies reported for macerated fresh fruit preparations ex 1 was a vacuum dried powder of the macerated extract of fresh fruit u02dc 25 1 ex 2 was a freeze dried powder of the macerated extract of fresh fruit u02dc 25 1 ex 3 was a spray dried powder of the macerated extract of fresh fruit u02dc 25 1 ex 4 was a vacuum dried powder of the macerated extract of fresh fruit adsorbed onto powdered vacuum dried fresh fruit u02dc 15 1 dosages of the extracts mg kg bodyweight day were 50 and 250 mg kg as indicated after an overnight fast the extract samples suspended in 5 gum acacia were administered to the animals by gastric intubations with a syringe for test purposes glucose was given orally by intubation as a 40 solution 1 g kg body wt blood samples following the glucose challenge were collected for the measurement of blood glucose from the tail vein at 0 1 2 3 and 4 hrs the blood glucose level was determined by using an electronic glucometer accu check roche diagnostic first the hypoglycemic activity of bitter melon extracts was studied in normal rats the.