46984 the ic 50 39 s for inhibition of collagen induced aggregation by sc 44161 and sc 46984 in dcg prp were 1 14 u00d7 10 5 m and 2 09 u00d7 10 6 m respectively fig i shows the data obtained when rats were intravenously injected with sc 44161 sc 46984 and sc 46985 in this model sc 44161 had an ed 50 of 31 mg kg the two enantiomers of sc 44161 sc 46984 and sc 46985 were tested in the same model for comparison sc 46984 has an ed 50 of 8 7 u03bcg kg approximately 3 5 times more potent than sc 44161 while sc 46985 had an ed 50 of 45 u03bcg kg approximately 1 5 times less potent than sc 44161 the potency of sc 44161 was determined when compound was administered i g and compared with sc 46984 and sc 47721 fig2 sc 44161 had an i g ed 50 of 1 21 mg kg in the same model sc 46984 had an i g ed 50 of 0 44 mg kg approximately 2 8 times more potent than sc 44161 for comparison sc 47721 was tested at 1 mg kg and gave 37 5 inhibition at that dose from the i v and the i g studies an i v i g ratio was calculated for sc 44161 the i v i g ratio was 39 and for sc 46984 the ratio was 51.