alkenyl substituted or unsubstituted alkanoyl substituted or unsubstituted alkenoyl wherein the double bond is cis and carbonyl substituted aryl and wherein the subtituent is each an independent group or linked together thereby forming a ring and wherein x is one or more substituted or unsubstituted group containing one or more o n or s atom and wherein the substituent is each an independent group or linked together thereby forming a ring and wherein the therapeutic agent is an alcohol containing water insoluble steroids or another alcohol containing compounds and methods to prepare such compounds application_number US 89000601 A description all patent applications patents and literature references cited in this specification are hereby incorporated by reference in their entirety in case of inconsistencies the present description including definitions will prevail u201c phospholipid conjugated u201d or u201c phospholipid derivatized u201d defined herein as covalently bonded to a phospholipid moiety via a phosphodiester linkage u201c significantly enhanced bioactivity u201d or u201c significantly more soluble in aqueous media u201d in terms of the conjugated drugs of the present invention is defined herein as no less than 5 to 10 fold increased biological activity and or aqueous solubility as compared to the unconjugated parent compound when administered by the same route the present invention is directed to increasing the bioavailability and or aqueous solubility of pharmaceutically active agents specifically by conjugation of such agents to phospholipids such as a phosphocholine moiety via a phosphodiester bond in accordance with the present invention therapeutic substances will benefit by increasing their water solubility and their bioavailability by forming a phosphodiester between an a alcohol and b a phospholipid non limiting examples of the phospholipid include.