solution which is then stirred until precipitation occurs the precipitate obtained is then suction filtered off and recrystallised from toluene and the title product is obtained in the form of a white solid the amine obtained in step b in the form of a base 6 4 g 27 mmol is dissolved in 60 ml of ethyl formate the reaction mixture is heated at reflux for 6 hours with stirring and then evaporated under reduced pressure the residue obtained is taken up in ether the organic phase is then washed in succession with acidic water 1n hcl water and a 10 hydrogen carbonate solution subsequently dried over magnesium sulphate filtered and evaporated under reduced pressure to yield the title product in the form of a yellow oil the formaldehyde obtained in step c 6 8 g 23 mmol is dissolved in 100 ml of acetonitrile then the reaction mixture is heated to approximately 60 u00b0 c phosphorus oxychloride 7 ml is added to the solution which is heated at reflux for 6 hours with stirring and then evaporated under reduced pressure the residue obtained is taken up twice in ethanol and evaporated under reduced pressure and is then taken up in water the aqueous phase is washed with dichloromethane and then rendered alkaline with a saturated sodium hydrogen carbonate solution and extracted with dichloromethane the organic phase is dried over magnesium sulphate filtered and evaporated under.