organic phase was combined and was sequentially washed with 40 ml 1 n hydrochloric acid 40 ml saturated sodium bicarbonate and 40 ml saturated brine and then was dried on magnesium sulfate after concentration an oily substance 31 5 g was obtained the mass spectrum showed a molecular ion peak wherein m 1 is 704 hplc purity is 79 5 20 0 g 0 028 mol white solid obtained in example 4 was dissolved in 100 ml methanol and naoh solution was added to adjust the ph value to 13 the reaction was conducted for a half hour subsequently 100 ml ethyl acetate was used to extract for 3 times the organic phase was washed with 100 ml water and 100 ml saturated brine after drying on magnesium sulfate and concentration an oily substance 9 8 g was obtained as 3 7 cyano 5 r 2 r 1 phenylethylamino propyl 1 h indolyl propyl alcohol compound ii wherein r is h the oily substance was added to the reactor and then 16 7 g 0 056 mol compound iv 9 0 g 0 028 mol tetrabutylammonium bromide 10 8 g 0 084 mol diisopropylethylamine and 15 ml n methylpyrrolidone were added under stirring the reaction mixture.