is selected from the group consisting of amyloidosis alzheimer 39 s disease type 2 diabetes mellitus and osteoarthritis which method comprises administering to the subject a therapeutically effective amount of the compound of formula i the invention further provides a method of treatment of a disease or disorder in a subject wherein the disease or disorder is selected from the group consisting of amyloidosis alzheimer 39 s disease type 2 diabetes mellitus and osteoarthritis which method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition as herein described the invention further provides a method of treatment of a disease or disorder in a subject wherein the disease or disorder is selected from the group consisting of alzheimer 39 s disease type 2 diabetes mellitus and osteoarthritis which method comprises administering to the subject a therapeutically effective amount of the compound of formula i the invention further provides a method of treatment of a disease or disorder in a subject wherein the disease or disorder is selected from the group consisting of alzheimer 39 s disease type 2 diabetes mellitus and osteoarthritis which method comprises administering to the subject a therapeutically effective amount of a pharmaceutical composition as herein described the invention further provides a method of treatment of a disease or.