5 474 796 and 5 807 522 both of which are hereby incorporated by reference herein the following examples are provided as a guide for a practitioner of ordinary skill in the art the examples should not be construed as limiting the invention as the examples merely provide specific methodology useful in understanding and practicing an embodiment of the invention male sprague dawley crl cd u00ae sd igs br rats charles river laboratories portage mich weight matched 7 to 8 weeks of age were housed individually in hanging stainless steel wire bottom cages in a temperature 66 77 u00b0 f light 12 hour dark light cycle and humidity 30 70 controlled room water and rodent diet were available ad libitum throughout the 5 day acclimatization period and during the 5 day treatment period housing and treatment of the animals were in accordance with regulations outlined in the usda animal welfare act 9 cfr parts 1 2 and 3 rats three per group were dosed daily at either a low or high dose the low dose was an efficacious dose estimated from the literature and the high dose was an empirically determined maximum tolerated dose defined as the dose that causes a 50 decrease in body weight gain relative to controls during the course of the 5 day range finding study animals were necropsied on days 0 25 1 3 and 5 up to 13 tissues e g liver kidney.