the influence of the stray light and the interruption substance is lowered the amount of the biogenic substance such as glucose contained in a living body is significantly lower than the amount of the interruption substance contained in the living body accordingly normal raman scattering of glucose has significantly smaller intensity than the raman scattering of the interruption substance contained in the skin surface the corneum in the epidermal tissue 1 in the epidermal tissue 1 or in the dermal tissue 2 for this reason it is hard to extract the normal raman scattering of glucose however the particle chip 3 can selectively enhance the raman scattering of glucose contained in a body fluid of the dermal tissue 2 on the periphery of the metal particles 13 this increases the intensity of the raman scattering of glucose selectively compared to the intensity of the raman scattering of the interruption substance since the intensity of the surface enhanced raman scattering of glucose is proportional to the concentration of glucose the concentration of glucose can be calculated from the intensity of the surface enhanced raman scattering of glucose the surface enhanced raman scattering spectrum of glucose is shown in fig1 of chanda ranjit yonzon cristy l haynes xiaoyu zhang joseph t walsh jr richard p van duyne u201c a glucose biosensor based on surface enhanced raman scattering improved partition layer temporal stability reversibility and resistance to serum protein interference u201d analytical chemistry.