comprising the active domain the active peptide may have any number of amino acids added to the n terminus and or c terminus of the active domain as long as the active domain has the activities described above such amino acids may be amino acids naturally adjacent to the active domain or may be amino acids that are not naturally adjacent to the active domain the protein u201c bil3 brz insensitive long hypocotyl 3 u201d is encoded by arabidopsis thaliana bil3 gene bil3 is an extracellular secretion type protein that has a full length of 63 amino acids represented by seq id no 8 ncbi id no at1g49500 and has an n terminal extracellular transport signal secretory signal positions 1 to 32 of seq id no 8 a c terminal active domain see fig2 positions 53 to 61 of seq id no 8 that is highly conserved across species and a cleavage site positions 48 to 49 of seq id no 8 therebetween see fig1 bil3 is cleaved at the cleavage site after translation to remove the extracellular transport signal peptide the active domain undergoes n terminal processing and c terminal processing and is then extracellularly secreted as a peptide hormone similar processing of active peptides has been reported as to for example arabidopsis thaliana psy1 amano y et al 2007 proc natl acad sci usa 46 18333 18338 thus the active domain of bil3 is presumably composed of the sequence of 9 amino acids represented by seq id no 1 bil3 has three arabidopsis thaliana paralogs ncbi id no at3g19030 ncbi id no.