extracted by et 2 o 50 ml the et 2 o phase was washed by nacl 20 ml the aqueous phase was washed by et 2 o the organic phases were combined and then concentrated to give z pglnme ome 324 mg structure confirmed by 1 h nmr and mass spec to a solution of z pglnme ome 324 mg in meoh 10 ml was applied a vacuum then argon purging was repeated twice but on the third time pd c u02dc 0 5 g was added purging was repeated twice more and on the third time the vacuum was quenched by bubbling hydrogen through the solution acoh 0 5 ml was then added after 90 min tlc indicated no starting material and so the solution was filtered celite washing with a large volume of meoh and concentrated to give pglnme ome 380 mg as a gum structure was confirmed by 1 h nmr to a solution of z d phepro 0 187 mg 1 eq in dmf 2 ml was added dipea 0 084 ml 1 eq and pybop 0 25 mg 1 eq with stirring under argon after 10 min a solution of pglnme ome 0 09 mg 0.