with 1n hcl basify with naoh to ph 10 extract with ch 2 cl 2 and wash with water and then brine dry the organic with mgso 4 and concentrate to give the piperazine as a white solid in a similar fashion prepare the following piperazines from the appropriate fluoride et is ethyl 1 4 2 methoxyethoxy phenyl piperazine is prepared from 4 4 hydroxyphenyl 1 acetylpiperazine to nah 60 in mineral oil 0 79 g 20 mmol in dmf 25 ml add the phenol 3 0 g 13 6 mmol followed by 2 bromoethyl methyl ether 2 27 g 16 3 mmol stir at rt 18 h concentrate and partition between etoac and 5 citric acid wash the organic with 1n naoh then brine dry over mgso 4 and concentrate to obtain the alkylated product as a white solid heat this material 2 2 g 7 9 mmol in 6n hcl 30 ml at reflux for 1 h allow to cool and basify to ph 10 with naoh extract with ch 2 cl 2 and wash with water and then brine dry the organic with mgso 4 and concentrate to give the piperazine as a yellow oil in a similar fashion except basic hydrolysis is employed for the cyclopropylmethyl ether prepare the following piperazines 4 2 methylaminoethoxy fluorobenzene is prepared from 4 2 bromo ethoxy fluorobenzene combine the bromide.