the term u201c alkenyl u201d refers to an a straight or branched chain alkenyl moiety having 1 or more carbon atoms bound by at least one double bond the term u201c amine u201d refers to organic compounds containing a nitrogen atom the term u201c pentostatin aglycone u201d refers to the 5 7 ring system nucleobase of pentostatin the term u201c pentostatin analogs u201d includes pentostatin molecules with a modified sugar moiety including the sugar modifications set forth herein the person of ordinary skill will also understand that pentostatin analogs include substitutions along the seven member aglycone ring the 7 member ring constituents themselves can also be replaced with different constituents in particular the carbon atom between the two nitrogen constituents on the seven member ring can be altered based on the orthoester used in cyclization procedure further the chirality of the o attached to the seven member aglycone ring can produce stereoisomers depending on the chirality of the diethyl tartarate starting material the term u201c pentostatin aglycone analog u201d includes the 5 7 ring system nucleobase of pentostatin with substitutions along the seven member aglycone ring the 7 member ring constituents themselves can also be replaced with different constituents in particular the carbon atom between the two nitrogen constituents on the seven member ring can be.