to a solvent in which the reactants can dissolve and which does not adversely participate in the reaction either by itself reacting with one or more components of the reaction mixture or by interfering with the reaction of the components with one another for any given reaction selecting a suitable solvent is well within the ability of those skilled in the art and can be accomplished without undue experimentation the term u201c subject u201d refers to an animal species capable of being infected by a pathogenic bacterium and in a particular embodiment includes humans appropriate animal subjects also include those in the wild livestock e g raised for meat milk butter eggs fur leather feathers and or wool beasts of burden research animals companion animals as well as those raised for in zoos wild habitats and or circuses in a particular embodiment a u201c subject u201d of the invention is a u201c food producing u201d animal for purposes of the present invention the term u201c food producing u201d animal shall be understood to include all animals bred for consumption or for consumables e g dairy cows egg laying hens and the like by humans and or other animals a non limiting list of such animals include avians chickens turkeys geese duck ostriches etc bovines e g cattle dairy cows buffalo ovines.