this example illustrates the synthesis of an alpha helix mimetic having thefollowing structure xv str16 the alpha helix of structure xv is prepared in a synthetic reaction scheme identical to the scheme disclosed in fig1 for structure xiv except thatinstead of using a protected version of glutamic acid i e compound 4 in fig1 as a starting material the following protected version of aspartic acid 4 39 was employed str17 c synthesis of other alpha helix mimetics other synthetic routes may be utilized to prepare alpha helix mimetics of structure i for example to prepare derivatives of structure i where r 3 is methyl u03b1 methyl glutamic or aspartic acid may be utilized in a reaction sequence as illustrate in fig1 these u03b1 amethyl derivatives may be prepared as described in zydowsky et al j org chem 55 5437 1990 in this reaction sequence the methyl group is derived from reactant alanine 2 hydroxybenzaldehyde is condensedwith alanine under basic conditions to yield an intermediate which may be alkylated with either a 2 bromopropionic acid equivalent or a 2 bromoethanoic acid equivalent to yield after hydrolysis a u03b1 methyl glutaric or aspartic acid derivative suitable for condensation with a suitable hydrazine to provide the alpha helix mimetic of structure i alternatively r 4 or r 5 substituted derivatives of structure i may be prepared as described in fig1 utilizing 3 substituted glutamic oraspartic acid derivatives which may be prepared according to the procedure described in baldwin et al tetrahedron 45 1465 1989 in this procedure protected versions of these amino acids may be directly alkylated at the carbon alpha to.