lnventioncomponent 1 2 3______________________________________morphine hydrochloride 1 10 0 011 menthol 5 5 5ethanol 40 40 40water 54 45 54 99______________________________________ as shown in fig2 a 2 b nd 2 c and table 4 the results showed that the medicine is absorbed percutaneously corresponding to the concentration of morphine hydrochloride i e 0 01 w in fig2 a 1 w in fig2 b and 10 w in fig2 c table 4__________________________________________________________________________unit u03bcg cm sup 2 this invention this invention this inventiontime 1 2 3elapsed mean deviation mean deviation mean deviation__________________________________________________________________________2 629 20 9 6256 213 8 45 0 084 1436 87 3 14399 671 17 4 0 346 1732 90 9 20323 940 27 7 1 038 1893 111 24958 1142 35 0 0 6310 18410 1580 40 4 0 88__________________________________________________________________________ formulations containing different kinds of percutaneous absorption accelerators were prepared as shown in table 5 and comparatively examined for percutaneous absorbability of morphine hydrochloride in the same manner as in example 1 table 5______________________________________unit w this inventioncomponent 1 4 5______________________________________morphine hydrochloride 1 1 11 menthol 5 terpineol 5 peppermint oil 5ethanol 40 40 40water 54 54 54______________________________________ consequently as shown in fig3 and table 6 excellent percutaneous absorbability was shown for every percutaneous absorption accelerator but particularly the best was terpineol table 6__________________________________________________________________________unit u03bcg cm sup 2 this invention this invention this inventiontime 1 4 5elapsed mean deviation mean deviation mean deviation__________________________________________________________________________2 629 20 9 1046 44 5 854 65 24 1436 87 3 2111 107 1766 64 76 1732 90 9 3163 226 2283 73 38 1893 111 3884 223 2662 93 810 3087 100__________________________________________________________________________ to examine the effect of the concentration of l menthol on the skin.