untreated group was used as a negative control ue8a0 group administered with 20 u03bcl of paclitaxel lipiodol tricaprylin formulation 200 u03bcg of paclitaxel u25ef untreated group one milliliter of lipiodol lipiodol ultra fluid laboratoire guerbet france iodine content 38 by weight was used as an oily contrast medium lipiodol and 2 4 6 8 10 or 11 mg of paclitaxel samyang genex korea were added in test tubes micro test tubes with safety lock polyethylene 1 5 ml eppendorf ag germany and solubilized by stirring at room temperature to speed up the solubilization process it is acceptable to raise the temperature to 35 u02dc 45 u00b0 c or to sonicate in a bath type sonicator when 2 u02dc 10 mg of paclitaxel was added in 1 ml of lipiodol paclitaxel was completely solubilized in lipiodol as evidenced by the formation of clear single liquid phase when 11 mg of paclitaxel was added to 1 ml of lipiodol however clear liquid was formed initially but the turbidity of the solution increased after overnight storage at room temperature paclitaxel precipitation was observed under a microscopy therefore it was confirmed that the solubility of paclitaxel in lipiodol is approximately 10 mg ml at room temperature 24 u02dc 28 u00b0 c viscosity of the paclitaxel lipiodol 10 mg 1 ml formulation was measured using a kinematic viscometer cannon fenske type calibrated cat no 13 617e size 200 fisher scientific pittsburgh pa by measuring the falling time of the liquid formulation and was 67 cp at 25 u00b0 c since the viscosity was higher than 45 cp embolization effect is maximized it is expected that paclitaxel lipiodol composition has an excellent embolization.