yang r d kawamura i blackburn g l bistrian b r j lab clin med 100 844 1982 and this has been supported by studies in animal models use of il 1 as an immunological reagent in humans or animals is likely because of its ability to stimulate t and b cells and increase immunoglobulin synthesis in fact il 1 appears to be an excellent candidate for the body 39 s endogenous adjuvant thus it is possible to use il 1 or parts of the il 1 molecule in certain immunogens a further aspect of the claimed invention concerns antibodies to human il 1 u03b2 that are raised by immunizing an animal with the precusor il 1 u03b2 protein or fragments thereof the following examples are illustrative of the process and products of the subject invention but are not to be construed as limiting all percentages are by weight and all solvent mixture proportions are by volume unless otherwise noted human mononuclear cells 4 6 u00d7 10 9 were isolated from ficoll hypaque gradient separation of plateletphoresis by products cells were washed 4 u00d7 in 0 9 nacl at 600 u00d7 g to remove platelets monocytes were plated into flat glass bottles in rpmi gibco containing 1 v v heat inactivated human ab serum at a density of 1 25 u00d7 10 6 cells cm 2 and allowed to adhere for 1 5 h at 37 u00b0 the bottles were then vigorously shaken and the non adherent population drained and counted the total number of adherent.