alkyl by reacting the compound 1 with succinic anhydride or glutaric anhydride through nucleophilic reaction wherein a is 2 or 3 by reacting the compound 2 with excess 4 to 6 times of pentaerythritol through esterification reaction wherein a is 2 or 3 by reacting the compound 3 with 3 isocyanatopropyltriethoxysilane or 3 isocyanatopropyltrimethoxysilane through nucleophilic reaction wherein r 51 is u2014 conh ch 2 3 si x 3 in which x is ethoxy or methoxy by reacting the compound 3 with 6 bromohexanoyl chloride through esterification reaction following reacting with dimethylamine gas saturated tetrahydrofuran solution through nucleophilic reaction and then reacting with 3 bromopropyltriethoxysilane or 3 bromopropyltrimethoxysilane through nucleophilic reaction wherein r 52 is u2014 co ch 2 5 n ch 3 2 ch 2 3 si x 3 y in which x is ethoxy or methoxy and y is halogenated group by reacting the compound 3 with succinic anhydride or glutaric anhydride through nucleophilic reaction following reacting with 3 aminopropyltriethoxysilane or 3 aminopropyltrimethoxysilane through condensation reaction and then dehydrating wherein r 53 is u2014 co ch 2 2 conh ch 2 3 si x 3 or u2014 co ch 2 3 conh ch 2 3 si x 3 in which x is ethoxy or methoxy a method for making the hybrid lipid compound with a following constructional formula comprises following steps wherein r 1 is c 6 u02dc c 18 alkyl r 2 is c 6 u02dc c 18 alkyl r 1 and r 2 is the same a is 2 or 3 r 511 is u2014 conh ch 2 3 si x 3 in which x is ethoxy or methoxy by reacting alkyl amines and alkyl bromide with the molar ratio of 1 2.