afford the n protected symmetric biphenyl peptides 6a c boc protecting groups are removed by treating 6a c with acid the crude product can be subsequently reacted with various alkyl or aryl acetyl chlorides to produce the final acylated products 7a c an alternative synthetic route as shown in scheme 2 below can be used to obtain symmetric dithiazolylbiphenyl analogs 7a c in this synthetic route the essential intermediate 4 4 u2032 bis 2 s pyrrolidin 2 yl thiazol 5 yl biphenyls compounds 5a c can be prepared in a similar manner as shown in scheme 1 subsequent coupling of 5a c with compound 8 affords analogues 7a c modification of the synthetic routes shown in schemes 1 and 2 leads to preparation of certain compounds of this invention for example various multi heteroaryl moieties of the compounds of this invention can be synthesized by coupling heteroaryl bromides e g 12a u02dc c 16a u02dc c or 21a u02dc c shown in schemes 3 6 below with arylboronic ester derivatives e g 13a u02dc c 20a u02dc c or 22a u02dc c also shown in schemes 3 6 below as shown in scheme 3 below a simple method can be utilized to directly convert commercially available n boc l proline 9a u02dc c into primary amide 10a u02dc c in good yield by using ammonium carbonate.