structure the commonly known tetracycline analogues and derivatives include the following oxytetracycline chlortetracycline demeclocycline doxycycline minocycline rolitetracycline lymecycline sancycline methacycline apicycline clomocycline guamecycline meglucycline mepyclcline penimepicycline pipacycline etocycline penimocycline and meclocycline tetracycline derivatives that can be used as described herein include tetracycline derivatives modified at positions 1 through 4 and 10 through 12 although these modifications may result in reduction in antibiotic properties according to mitscher et al j med chem 21 5 485 489 1978 the configuration of the 4 carbon is important to the antibiotic properties of the tetracyclines for the antibiotic tetracyclines carbon 4 is in the s configuration the 4 epimers of the tetracyclines which have the r configuration at the 4 carbon have significantly reduced antibiotic activity other such non antibiotic tetracycline analogs include the 4 de dimethylamino derivatives of the tetracyclines listed in the above paragraph specific examples include 6 demethyl 6 deoxy 4 dedimethylaminotetracycline 6 demethyl 6 deoxy 4 dedimethylamino 7 dimethylaminotetracycline 6 demethyl 6 deoxy 4 dedimethylamino 7 chloro tetracycline 4 hydroxy 4 dedimethylaminotetracycline 6a deoxy 5 hydroxy 4 dedimethylaminotetracycline 4 dedimethylamino 5 oxytetracycline and 4 dedimethylamino 11 hydroxy 12a deoxytetracycline further examples of tetracyclines with reduced antibiotic activity include 6 u03b1 benzylthiomethylenetetracycline 6 fluoro 6 demethyltetracycline and 11 u03b1 chlorotetracycline other tetracycline related compounds that can be used as described herein are the 9 substituted amido tetracyclines the latter include the compounds described in.