mg to 30 mg kg through oral gavage daily for 6 days the control group received vehicle dose 10 ml kg on 6th day the blood samples were collected one hour after administration of test compounds vehicle for assessing the biological activity the random blood sugar and triglyceride levels were measured by collecting blood 100 u03bcl through orbital sinus using heparinised capillary in tubes containing edta which was centrifuged to obtain plasma the plasma glucose and triglyceride levels were measured spectrometrically by glucose oxidase and glycerol 3 po 4 oxidase peroxidase enzyme dr reddy 39 s lab diagnostic division kits hyderabad india methods respectively the blood sugar and triglycerides lowering activities of the test compound was calculated according to the formula 1 percent reduction in blood sugar triglycerides were calculated according to the formula percent ue89e ue89e reduction ue89e ue89e 1 tt ot tc oc u00d7 100 body weight of the animals were measured at the beginning and at the end of the study period no adverse effects were observed for any of the mentioned compounds of invention in the above test the experimental results from the db db mice suggest that the novel compounds of the present invention also possess therapeutic utility as a prophylactic or regular treatment for diabetes obesity cardiovascular disorders such as hypertension hyper lipidaemia and other diseases as it is known from the literature that such diseases are interrelated to each other b plasma triglyceride and body weight reduction in swiss albino mice male swiss albino mice sam were obtained from nin and housed in drf animal house all these animals were maintained under 12 hour light and dark cycle at 25 u00b1 1 u00b0 c animals.