and the residue was subjected to column chromatography through silica gel eluted with chloroform 1 0 g of a glassy substance was obtained from the eluate this substance was dissolved in 10 ml of chloroform and then 1 ml of 10 w w hydrogen chloride ethanol was added to the resulting solution the resulting precipitate was dried giving 0 70 g of the title compound in the form of a pale yellow powder melting at 198 u00b0 200 u00b0 c with decomposition calculated for c 34 h 41 n 6 o 7 s hcl h 2 o c 55 76 h 6 06 n 11 48 cl 4 84 s 4 38 found c 55 71 h 6 13 n 11 48 cl 4 74 s 4 70 to 20 ml of chloroform were added 0 71 g of 1 d 3 acetylthio 2 methylpropanoyl l proline and 0 5 g of triethylamine after which the mixture was cooled with ice water 0 3 g of ethyl chloroformate was added with stirring and then the mixture was stirred for a further 20 minutes at the end of this time 10 ml of a chloroform solution containing 1 15 g of 4 amino 2 4 4 benzyloxybenzoyl 1 piperazinyl 6 7 dimethoxyquinazoline were added the mixture was then stirred for 1 hour with ice cooling and then for 15 hours at room temperature at the end of this time the reaction mixture was concentrated by evaporation under reduced pressure and the resulting residue was subjected to column chromatography through silica gel.