m 1 ch 4 07 t 2 och 2 j 5 0 4 83 d 1 ch c u2550 o j 11 8 6 57 to 7 90 m 13 aromatic h 8 77 wide 1 oh interchangeable with d 2 o 20 g of a powdered active ingredient are mixed with 40 g lactose and 140 g starch and subsequently intermixed with 33 g talcum and 13 g calcium stearate after careful mixing the composition is filled into 2000 hard gelatine capsules of a suitable size each capsule containing 10 mg of the active ingredient 20 g of a finely powdered active ingredient are mixed with 111 g mannitol 15 g corn starch and 6 g alginic acid and granulated the dried granulate is mixed carefully with 0 75 g methyl cellulose and 1 5 g magnesium stearate and pressed into 1000 tablets so that each tablet contains 20 mg of the active ingredient the measurement of the bonding affinity to the estradiol receptor was affected by the method of n devleeschouwer g leclercq a danguy and j c heuson europ j cancer 14 721 723 1978 the uterus cytosal of female prepubertal white rabbits new zealand weighing 2 kg was incubated for 18 hours at 40 u00b0 c with 2 5 u00d7 10 9 m 3 h estradiol with the further addition of unmarked estradiol control or the test substance in different concentrations the bonding affinity to the estradiol receptor is expressed by the concentration of unmarked estradiol control or the test substance added to the uterus cytosol which effects a 50 displacement of the 3 h estradiol bound to the estradiol receptor table.