08 9h s c ch 3 sub 3 2 96 3h s gt n ch 3 4 46 1h d of d str15 7 21 2h s h of benzene ring in 8 ml of tert butylamine was dissolved 0 4 g of 3 5 dichloro 4 methoxycarbonylamino u03b1 bromomethylbenzyl alcohol and the solution was heated overnight to 50 u00b0 c in a sealed tube after cooling the reaction mixture was concentrated under reduced pressure to provide a yellow oily material the oily material was dissolved in 50 ml of methanol and after adding 5 ml of water and excessive amount of sodium carbonate to the solution the mixture was stirred for 30 minutes the mixture was concentrated under reduced pressure and the residue was dissolved in 50 ml of chloroform and washed with saturated aqueous sodium chloride solution the mixture was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to provide a yellow oily material the oily material was applied to a 15 ml silica gel column chromatography and developed after passing 300 ml of chloroform through the column methanol was used as eluting solution to provide 0 09 g of 3 5 dichloro 4 methoxycarbonylamino u03b1 tert butylaminomethylbenzyl alcohol having a melting point of 162 u00b0 164 u00b0 c u2202 1 80 s 9h c ch 3 3 2 77 m 2h ch 2 n lt 3 74 s 3h cooch 3 4 50 m 1h str16 7 34.