granulation tissue grew out from the drilled holes fig4 and fig5 after continuous application the skin on the granulation tissues expanded and healed the wounds and the new granulation tissues grew out of the holes connected with each other and regenerated new skin on the new bone granulation tissues fig6 referring to fig2 the patient was subjected to the electrical injury on the top of head combined with skull periosteum burnt and skull surface necrosis firstly the pharmaceutical composition 7 and 8 were used as the control drugs for 25 days after treatment there was no obvious improvement of skull necrotic surface then the pharmaceutical composition 2 obtained from example 2 was used to continue the treatment the treatment method was to apply the pharmaceutical composition on the wounds directly with thickness of about 1 3 mm and the dressing was changed twice in every morning and night respectively for 7 days after 7 days treatment remove the necrotic bone tissues from outside to inside with surgical debridement and then drill the holes on the bones with drilling interval less than 1 cm until the bleeding of bone marrow then the pharmaceutical composition 2 was applied on the wounds with the thickness of about 1 3 mm and the dressing was changed twice in every morning and night respectively fig8 after 10 days the granulation tissues grew out of the drilled holes and new skin gradually regenerated and connected with each other to close the bone wounds fig9 after the bone wounds healed the skin tissues can be seen fig1.