m 5h 7 31 7 25 m 2h 4 58 t j 6 4 hz 2h 3 92 t j 6 4 hz 2h 3 57 3 55 m 2h 3 48 3 45 m 2h 3 35 s 3h 13 c nmr 400 mhz cdcl 3 u03b4 148 9 143 8 141 0 140 6 129 9 127 9 126 1 125 4 124 6 123 4 122 9 120 4 119 5 119 2 119 1 109 4 109 2 71 9 70 9 69 3 59 1 43 3 hrms maldi tof m z calcd for c 32 h 29 n 2 o 2 473 2223 found 473 2210 m h a solution of 12 0 20 g 0 4 mmol and methyl iodide 0 57 g 4 mmol in acetonitrile 8 ml was heated to 100 u00b0 c in sealed tube for 24 h after cooling down to room temperature the solvent was removed and the resulting mixture was purified by precipitation from methanol and ethyl acetate to afford sam 0 15 g in 61 yield 1 h nmr 400 mhz cdcl 3 u03b4 8 74 d j 8 0 hz 2h 8 49 s 1h 8 46 d j 8 8 hz 2h 8 31 d j 16 hz 1h 8 26 t j 8 0 hz 2h 8 10 d j 8 0 hz 1h 7 93 d j 8 0 hz 1h 7 83 t j 7 2 hz 211 7 51 d j 8 4 hz 1h 7 46 t j 6 4 hz 2h 7 44 d j 16 hz 1h 7 20 t.