relates to a nucleic acid construct which comprises a at least one nucleic acid sequence of the promoter according to the invention component a and where appropriate b at least one effector gene component b with the transcription of this effector gene being activated by component a component a is preferably located upstream of component b the invention furthermore relates to a nucleic acid construct in which the promoter sequence of the endoglin gene according to the invention is combined with another target cell specific virus specific metabolism specific or cell cycle specific promoter sequence and with at least one effector gene in which this combination of promoter sequences controls the activation of at least one effector gene a nucleic acid construct according to the invention is preferably composed of dna the term 34 nucleic acid construct 34 is understood as meaning artificial structures which are composed of nucleic acid and which can be transcribed in the target cells they are preferably inserted into a vector for example into non viral vectors such as plasmids or viral vectors the skilled artisan is familiar with the preparation of non viral vectors and of viral vectors such preparation is explained for example in sambrook j et al molecular cloning laboratory manual second edition cold spring harbor laboratory press.