hydrophobic monomer can be e g styrene or divinylbenzene a preferred copolymer is a poly divinylbenzene co n vinylpyrrolidone a preferred porous resin is a compound of formula i and salts thereof described supra preferably the porous resin is a sulfonated poly divinylbenzene co n vinylpyrrolidone in preferred embodiments the porous resin comprises at least about 12 mole percent n vinylpyrrolidone in preferred embodiments the porous resin comprises less than about 30 mole percent n vinylpyrrolidone by mole percent is meant the mole fraction expressed as a percent of the monomer of interest relative to the total moles of the various two or more monomers which compose the copolymer of the porous resin preferably the porous resin has solid phase extraction capability the porous resin can be in the form of e g beads pellets or any other form desirable for use the porous resin particles can have e g a spherical shape a regular shape or an irregular shape preferably the particles are beads having a diameter in the range from about 3 to about 500 u03bcm preferably from about 20 to about 200 u03bcm preferably the porous resin has a specific surface area in the range from about 50 to about 850 square meters per gram and pores having a diameter ranging from about 0 5 nm to about 100 nm in certain embodiments the porous resin is incorporated in a matrix in certain embodiments more than one type of functionalized porous resin can be used in the columns cartridges and the like of the present invention the solute can be e g any molecule having a hydrophobic hydrophilic or.