cells can survive and proliferate even with large nanoprobes inside them as seen in fig4 a c and fig1 f cells can divide and produce normal new cells with one of the cells containing the beam we find that 44 n 9 of cells that are loaded last three days or more and some as long as eight days the question of how normal these loaded cells are requires further investigation with gene expression profiling it is likely that some cellular activity is modified by the presence of the large probe however as mentioned above the probe can be shrunk in size by a factor of 3 5 in the future in any case by remaining in the cell the probe can be a useful reporter of optical information for various sensing applications over a long period of time fig1 a b show pl in loaded cells fig1 a is pl of a cavity probe before loading a single cell when pumped in air fig1 b is pl of the same cavity probe after being broken off and loaded into a cell we also examine the cavity properties after being loaded into a cell no longer tethered to the original template and fiber fig1 a shows a spectrum of a cavity probe prior to cellular insertion we then proceed to break off the nanobeam cavity from the full gaas template according to the procedure outlined above we measure the spectrum of the internalized nanobeam four hours later using the original multimode fiber as a collection optic the only change in the nanobeam during this period is a slight rotation due to cell movement fig1 b shows this spectrum revealing once.