death tunel positive and or negative cell cycle regulators before and after drug treatment is divided by the total number of tpf n and tsf factors m considered thus tpf1 is the change of promoting factor 1 after treatment and tsf1 is the change of suppressing factor 1 after treatment pdx 100 tpf 1 1 100 tpf 2 2 100 tpfn n 100 u2212 tsf 1 1 100 u2212 tsf 2 2 100 u2212 tsfm m n m wherein decrease or increase after drug treatment will render the values of tpf and tsf positive or negative respectively pdx score is between 0 and 100 in general a lower pdx score predicts better clinical outcome resulting from a given treatment a high pdx score indicates the treatment is not affecting the factors being monitored and a different treatment should be initiated for rtkis designed to inhibit receptors x y and z and induce cell death tunel positive prtk and trtk are measured by lsc mediated quantification of x y and z before and after treatment rtk generated by measuring prtk x trtk x before and after treatment then calculating the change for prtk x trtk x the pdx score is then generated by the following formula wherein rtk is the change for prtk x trtk x rtk is the change for prtk y trtk y rtk z is the change for prtk z trtk z and tunel is the change in tunel intensity before and after treatment for the sample 4 is the number of factors considered and pdx is a score.