sustained component of the potassium current in drg using a depolarization holding potential was also isolated both 4 ap and 4 ap 3 meoh did not significantly inhibit i dr data not shown therefore potassium current that is sensitive to 4 ap and 4 ap 3 meoh are mostly the fast potassium current i a while 4 ap 3 meoh has been shown above to enhance the cap propagation and block fast potassium channels in drg neurons 4 ap 3 meoh does not have a significant effect on cap activation threshold or on axonal response to dual or multiple stimuli to assess the cap activation threshold stimulus intensities from 1 85 to 6 5 v were applied to injured spinal cord tissue pre and post 100 u03bcm 4 ap 3 meoh treatment from these studies it was shown that 4 ap 3 meoh increased cap conduction at all stimuli intensity levels and that cap amplitude stimulus intensity curves were similar in pre and after 4 ap 3 meoh treatment data not shown post surgery sseps had been eliminated in all animals by the time electrical records could be accomplished lt 1 hour in all but two animals these u201c flat line u201d recordings were characteristic of the 1 week recordings as well indicating there was little evidence for spontaneous recovery of conduction in any of the guinea pigs one week after surgery in the two exceptions a small and very early arriving evoked potential.