part for each of the groups of mice is shown in fig6 a 6c from the histological scores for the distal part of the colon as set out in fig6 a 6c it could be concluded that there is a clear decrease of inflammation upon inoculation of mice with l lactis cells producing trefoil peptides mice having received pt1mtff1 transformed l lactis cells show a significant reduction of the inflammation of more than 65 as can be seen from fig6 a 6c the inflammatory infiltration and the epithelial damage in the distal part of the colon are significantly decreased following inoculation with recombinant l lactis strains which secrete mtff1 polypeptide these results were confirmed in a separate experiment which was conducted equally including larger groups group size 10 and more control groups fig7 shows histological scores obtained as described above of healthy control mice control and of mice which received dss as described either left untreated dss or treated as described above with mg1363 mg1363 pt1trex1 or mg1363 pt1mtff1 as indicated the experiment shows a clear and significant decrease in the intestinal inflammation in the group of mice treated with mg1363 pt1mtff1 the latter experiment was also evaluated by determining the levels of interleukin 1 u03b2 il 1 u03b2 and interferon u03b3 ifn u03b3 both pro inflammatory cytokines well known to the skilled mice n 10 were inoculated with the strains indicated as described control healthy mice dss mice receiving 5 dss in.