in keeping with our objective of providing long term stability to the oral solid dosage form of paroxetine hydrochloride we have selected excipients which would contribute to this characteristic objective we have chosen not to use excipients such as disaccharides such as maltose lactose sucrose and glucose solvents like water or any other aqueous solvent or solvents that are freely miscible with water have also not been used we have also considered a coating agent which would provide excellent protection against moisture and at the same time immediately release the drug in the gastro intestinal environment as desired paroxetine hydrochloride anhydrous has been chosen for experimental trials since it is considered more difficult to protect from moisture it is also an aspect of the present invention to provide a pharmaceutical composition incorporating paroxetine hydrochloride hemihydrate by using the process herein above the process has also provided positive results with regard to other moisture barrier excipients such as polyethylene glycols polyglycolised glycerides fatty alcohols stearic acid opadry amb oy b 28920 white and opadry 20a 58900 white fatty materials of plant and animal origin additionally the tablets may also be film coated with hydrophobic coating materials to help retard against degradation a coating solution of ethylcellulose was produced to dissolve in methylene chloride and iso propyl alcohol polysorbate was added to this solution the active was coated with this coating solution the coated granules formed were dried at a suitable temperature and screened through a mesh of appropriate size dicalcium phosphate microcrystalline cellulose and sodium starch glycollate were milled to which milled citric acid was geometrically mixed finally the dried mass of coated.