201414291639 A description u201c subjects u201d or u201c patients u201d refers to mammals including but not limited to humans suffering from cancers u201c maximum tolerated dose mtd u201d means the highest dose of a radiological or pharmacological treatment that will produce the desired effect without unacceptable toxicity in the present invention mtd is one dose level below the cohort in which 2 patients experienced a drug related dose limited toxicity in cycle 1 u201c cr u201d means a complete response was achieved after treatment that is all signs of cancer in the patient disappeared in response to the treatment u201c pr u201d means a partial response was achieved after treatment that is at the end of treatment there was some disease remaining but a reduction of disease by 30 or more on clinical examination or x rays and scans was achieved in the patient u201c sd u201d means a stable disease state was seen that is at the end of the treatment the disease state of the patient was little changed from pre treatment conditions u201c pd u201d means a progressive disease state was seen that is the disease shows more than a slight increase in size or extent on or after treatment u201c os u201d means overall.