approximated as the time required for 50 of the solvent to flow through the paper this time was 2 u00d7 faster for dmf than for nmp flow through rate may be related to the viscosity of the solvent and optimal flow through conditions may be designed and quantified using the method similar to that described in fig5 the flow can be accelerated if necessary by spinning the array in a centrifuge equipped with rotor for micro well plates flow can also be accelerated by applying a suction of air under the array for example a tube or array of tubes connected to vacuum underneath the array fig6 illustrates one example which describes assays to detect long term stability to organic solvents and conditions in which pattern fails the assay to detect failure of the pattern was the following u201c short term wash u201d the array was exposed to dmf for 3 cycles 1 minute each u201c long term wash u201d the array was exposed for 20 cycles to dmf 1 minute each cycle and or 24 hour immersion in dmf these conditions were selected to imitate the typical exposure of the arrays to the multi step organic synthesis the stroke thickness used to design the pattern during wax patterning process influenced the stability of teflon patterned array this stroke defined the thickness of the teflon containing barrier between the wells a teflon patterned array with very small barriers of teflon confined solvent only after u201c short term wash u201d after u201c long term wash u201d this pattern failed fig6 a the failure of this pattern was due to lt 1 mm thickness of the teflon protected area separating the.