manner for example in the case of diasteroisomeric isomers chromatographic separation may be employed compound names were generated with acdlabs version 12 5 some of the intermediate and reagent names used in the examples were generated with software such as chem bio draw ultra version 12 0 or auto nom 2000 from mdl isis draw 2 5 sp1 in general characterization of the compounds is performed according to the following methods nmr spectra are recorded on 300 or 600 mhz varian and acquired at room temperature chemical shifts are given in ppm referenced either to internal tms or to the solvent signal all the reagents solvents catalysts for which the synthesis is not described are purchased from chemical vendors such as sigma aldrich fluka bio blocks combi blocks tci vwr lancaster oakwood trans world chemical alfa fisher maybridge frontier matrix ukrorgsynth toronto ryan scientific silicycle anaspec syn chem chem impex mic scientific ltd however some known intermediates were prepared according to published procedures usually the compounds of the invention were purified by medium pressure liquid chromatography unless noted otherwise to the degassed mixture of 6 amino n dimethyl oxido u03bb 4 sulfanylidene 5 iodonicotinamide 1 19 g 3 51 mmol 1 eq 5 tert butoxycarbonylaminobenzothiophene 2 boronic acid 1 52 g 1 15 eq and aq sodium carbonate 2m 5 27 ml 3 eq in dioxane 7 5 ml was added ph 3 p 184 mg 0 2 eq and pd oac 2 79 mg 0 1 eq the mixture was heated to.