s 5 25 2h s 6 06 6 72 2h br 6 44 1h d 6 99 7 04 4h m 7 12 1h t 7 31 7 41 4h m 8 04 1h d 2 amino 6 methyl nicotinic acid 3 04 g was suspended in n n dimethylformamide 60 ml and potassium carbonate 5 53 g was added to the suspension followed by stirring at 40 u00b0 c for 30 minutes 4 phenoxybenzyl chloride 4 37 g was dropwise added to the resulting suspension followed by stirring with heating at 80 u00b0 c for 2 hours the reaction solution was cooled to room temperature and the n n dimethylformamide 35 ml 58 was removed by distillation under reduced pressure iced water 100 ml was added to the residue followed by stirring at room temperature for 10 minutes precipitated crystals were collected by filtration and were dried to give 6 42 g yield 96 of the target product compound 2 shown in table 1 according to purity analysis by liquid chromatography the purity of thus obtained target product was high 99 7 a melting point thereof was 122 u00b0 c to 124 u00b0 c 1 h nmr cdcl 3 u03b4ppm 2 38 3h s 5 25 2h s 6 06 6 72 2h br 6 44 1h d 6 99 7 04 4h m 7 12 1h t 7 31 7 41 4h m 8 04 1h d the 4 phenoxybenzyl chloride used in example 3 was synthesized by the following process 4 phenoxybenzyl alcohol 20 0 g was dissolved.