administered for treating human patients with an acquired hypercoagulable state or acquired protein c deficiency as described herein will be about 24 u03bcg kg hr recombinant human protein c r hpc was produced in human kidney 293 cells by techniques well known to the skilled artisan such as those set forth in yan u s pat no 4 981 952 the entire teaching of which is herein incorporated by reference the gene encoding human protein c is disclosed and claimed in bang et al u s pat no 4 775 624 the entire teaching of which is incorporated herein by reference the plasmid used to express human protein c in 293 cells was plasmid plpc which is disclosed in bang et al u s pat no 4 992 373 the entire teaching of which is incorporated herein by reference the construction of plasmid plpc is also described in european patent publication no 0 445 939 and in grinnell et al 1987 bio technology 5 1189 1192 the teachings of which are also incorporated herein by reference briefly the plasmid was transfected into 293 cells then stable transformants were identified subcultured and grown in serum free media after fermentation cell free medium was obtained.