were added to the mixture and the reaction mixture was stirred at 110 u00b0 c for 8 h the hot crude solution was filtered on a celite pad and washed with etoac 1 l the filtrate was concentrated under reduced pressure the crude residue was purified by flash column chromatography on silca gel using petroleum ether 100 to cyclohexane etoac 80 20 as eluent the resulting product was diluted in etoac 2 l the organic layer was washed two times with hcl 1n 1 l brine 1 l was dried over mgso 4 filtered and concentrated under reduced pressure to afford the title compound 70 g 41 according to scheme 1 step 6 to a solution of 5 benzylamino n methoxy 1 4 methoxybenzyl n methyl 1h pyrazole 4 carboxamide 66 1 g 174 mmol in anhydrous dmf 600 ml and anhydrous thf 600 ml at 0 u00b0 c was added portionwise 60 nah 20 8 g 521 mmol the mixture was stirred for 30 min then 3 bromoprop 1 ene 44 1 g 365 mmol was added to the mixture and the reaction mixture was stirred for 30 min at rt after cooling to 0 u00b0 c cold water 300 ml was added slowly to the reaction mixture.