or diamond particles may be coated with agents such as monoclonal antibodies small peptides proteins or drugs which when delivered intracellularly to target cells act to either kill or beneficially affect the cells for example cancer cells may be bombarded with particles coated with enzymes or catalytic antibodies where the enzyme or antibody catalyzes a lethal reaction inside the cell in another example monoclonal antibodies directed against oncoproteins are delivered to the cytoplasm of cancerous cells where the antibodies neutralize the activity of the oncoprotein and restore a normal growth pattern to the cells in other embodiments of the invention a small quantity of explosive in the operating head of the catheter or endoscope is employed to accelerate the particle or particles of gold diamond or other material into the cells adjacent the head or opening through which the particles are propelled the explosive may be a solid chemical liquid or gas ignited by a spark or laser beam the gas or liquid may be flowed through a tube in the instrument to an open end thereof passing sparking electrodes an exploding wire ignited by a high voltage or resistance heating means may also generate the shock or pressure wave the particles.