and then cooled to room temperature volatiles were removed in vacuo saturated aqueous ammonium chloride and ethyl acetate were added to the residue the organic layer was separated washed with brine dried over mgso 4 filtered and concentrated under reduced pressure purification by silica gel chromatography provided intermediate 64 c as beige solid to a solution of intermediate 53 a 2 69 g 12 0 mmol in thf 20 ml were sequentially added 4 methoxyphenyl methanol 1 38 g 10 0 mmol triphenylphosphine 3 15 g 12 0 mmol and diad 2 36 ml 12 0 mmol drop wise at room temperature and the reaction was then stirred for 1 hour saturated aqueous ammonium chloride and ethyl acetate were added the organic layer was separated washed with brine dried over mgso 4 filtered and concentrated under reduced pressure purification by silica gel chromatography provided intermediate 65 a as a colorless oil to a solution of intermediate 65 a 2 19 g 6 97 mmol in thf 10 0 ml was added tetrabutylammonium fluoride trihydrate 2 19 g 6 97 mmol and the reaction was stirred at room temperature overnight saturated aqueous ammonium chloride and ethyl acetate were added the organic layer was separated washed with brine dried over mgso 4 filtered and concentrated under reduced pressure purification by silica gel chromatography provided intermediate 65 b as a white solid a solution of intermediate 64 c 200 mg 0 61 mmol intermediate 65 b 280 mg 1 21 mmol quinolin 8 ol 18 0 mg 0 12 mmol copper i iodide 23 mg 0 12.