ovary cancer cervical cancer lung cancer breast cancer and skin cancer such as squamous cell and basal cell cancers prostate cancer renal cell carcinoma and other known cancers that effect epithelial cells throughout the body the compounds of the invention may also be useful in the treatment of angiogenesis mediated disorders thus a method for treating inhibiting or delaying the onset of an angiogenesis mediated disorder in a subject is provided comprising administering to a subject in need of such treatment an effective amount of a compound according to the present invention angiogenesis mediated disorders which may be treatable with cyclooxygenase inhibitors are discussed in u s pat no 6 025 353 the entire disclosure of which is incorporated herein by reference according to u s pat no 6 025 353 such disorders include for example metastasis corneal graft rejection ocular neovascularization retinal neovascularization diabetic retinopathy retrolental fibroplasia neovascular glaucoma gastric ulcer infantile hemaginomas angiofibroma of the nasopharynx avascular necrosis of bone and endometriosis the compounds may be administered by any route including oral and parenteral administration parenteral administration includes for example intravenous intramuscular intraarterial intraperitoneal intranasal rectal or subcutaneous administration the active agent is preferably administered with a pharmaceutically acceptable carrier selected on the basis of the selected route of administration and standard pharmaceutical practice the active agent may be formulated into dosage forms according to standard practices in the field of pharmaceutical preparations see alphonso gennaro ed remington 39 s.