was calculated according to the formula the results presented in table 8 demonstrate a pronounced anti inflammatory activity of compounds of formula i comparable with activity of the reference drug from the nsaid group indomethacin effective dose of the compound being by one order lower than in the reference drug the tests were carried out on females of outbreed rats weighing 300 320 grams the compounds tested were administered once intragastrally at a dose 30 mg kg to rats deprived of feed for 24 hours prior to the test animals in the control group were administered distilled water in the same volume at 24 hours the animals were sacrificed and stomachs were extracted an empty stomach was filled with 2 formalin solution and it was placed into a beaker with formalin 30 minutes later the stomach was opened along the great curvature expanded on a slide fixed and washed with distilled water using the magnifying glass mbs 9 8 fold magnification length and width of gastric mucosa defects was measured and area in mm 2 was calculated 1 division of the magnifying glass ruler 0 1 mm ulcerogenic effect of a substance was assessed by ulcerous lesion area of gastric mucosa according to the technique presented in rukovodstvo po experimental 39 nomu doklinicheskomu izucheniju novykh pharmacologicheskikh veshchestv the guide on experimental pre clinical study of novel pharmacological substances moscow u201c remedium u201d publishers 2000 398 pages the data obtained show that in intra gastric administration of the compound of general formula i at a dose 30 mg kg ulcerous lesion of gastric mucosa is absent the model of serotonin induced soft muscular contracture of an uterine horn blattner h g dehnert h et al experiments on isolated smooth muscle preparation.