of stabilizing agent sup 99 tc sup m labelling labelling of stabilizing yield interference from agent stabilizing agent______________________________________pentitolsxylitol none 81 not detectableribitol 34 79hexitolssorbitol none 56 appreciablemannitol 34 70hexosesglucose none 78 not detectablemannose 34 80galactose 34 80fructose 34 82sorbose 34 79hexosedisaccharidessucrose none 87 not detectablemaltose 34 82lactose appreciable inositolsmeso inositol none 85 not detectable______________________________________ considering that an 80 percent yield has been reported by labelling glucose with technetium 99m at ph 4 british patent application no 2 016 198 it is surprising that no labelling of the polyhydroxy compounds of the present invention was observed under the labelling conditions preferred herein i e ph 2 0 2 2 the formation of plasmin aggregates was investigated by subjecting plasmin compositions labelled or unlabelled to disc electrophoresis on polyacrylamide 7 5 in a ph 4 5 buffer containing 3m urea following the procedure of r mauerer disk electrophorese walter de gruyter berlin 1968 the fact that identical electrophoretic patterns were obtained for unlabelled and labelled plasmin preparations developed by staining and scintigraphic scanning respectively demonstrates that labelling in itself does not induce transformations of native plasmin however quantitative scanning of electropherograms obtained from the old sodium chloride containing composition after labelling revealed that extensive transformation of plasmin had taken place another sample 20 u03bcl was subjected to high pressure liquid chromatography on a waters protein analyses column i 125 waters associates inc mass usa the elution being conducted with phosphoric acid 0 2m at a flow rate of 0 25 ml min maximum pressure 200 p s i and monitored at 276 nm the chromatogram indicated that extensive transformation of plasmin to high molecular weight compounds or aggregates had occurred furthermore counting of the collected fractions each of 125 u03bcl demonstrated extensive labelling of aggregated plasmin application.