dispersion media coatings antibacterial and antifungal agents isotonic and absorption delaying agents and the like the use of such media and agents for pharmaceutically active substances is well known in the art except insofar as any conventional media or agent is incompatible with the active ingredient its use in the therapeutic compositions is contemplated supplementary active ingredients can also be incorporated into the compositions the term u201c therapeutically effective amount u201d or u201c effective amount u201d refers to that amount of a compound that is sufficient to effect treatment as defined below when administered to a mammal including humans in need of such treatment the therapeutically effective amount will vary depending upon the subject and disease condition being treated the weight and age of the subject the severity of the disease condition the particular compound chosen the dosing regimen to be followed timing of administration the manner of administration and the like all of which can readily be determined by one of ordinary skill in the art the term u201c treatment u201d or u201c treating u201d means any treatment of a disease in a mammal including a preventing the disease that is causing the clinical symptoms of the disease not to develop b inhibiting the disease that is slowing or arresting the development of clinical symptoms and or c relieving the disease that is causing the regression of clinical symptoms the active compounds according to the present invention may be administered by any suitable.