inhibitor comprising a providing a polypeptide comprising a protein kinase inducible domain having a structurally significant glutamic acid or aspartic acid residue replaced with a serine or threonine residue b contacting the polypeptide of a with 1 a protein kinase having a kinase recognition domain on polypeptide of a and 2 a test compound suspected of being a kinase inhibitor and c detecting phosphorylation of the serine or threonine residue of the polypeptide of a whereby inhibition of phosphorylation of the replaced serine or threonine residue is indicative of the test compound being a protein kinase inhibitor another embodiment is for a method of screening for a protein phosphatase inhibitor comprising a providing a polypeptide comprising a protein kinase inducible domain having a structurally significant glutamic acid or aspartic acid residue replaced with a phosphoserine or phosphothreonine residue b contacting the polypeptide of a with 1 a protein phosphatase having a phosphatase recognition domain on polypeptide of a and 2 a test compound suspected of being a phosphatase inhibitor and c detecting phosphorylation of the phosphoserine or phosphothreonine residue of the polypeptide of a whereby inhibition of dephosphorylation of the replaced phosphoserine or phosphothreonine residue is indicative of the test compound being a protein phosphatase inhibitor in some embodiments identification of kinase or phosphatase inhibitors can be accomplished through the use of high throughput screening assays to screen large number of compounds another aspect pertains to novel inhibitors identified by the above described screening assays accordingly it is within the scope of this disclosure to use as a kinase or phosphatase inhibitor a compound identified herein protein kinase inducible domains and or protein phosphatase inducible domains bind other metals including.