10 647 1972 in dimethyl formamide is reacted with iodopropyl carborane zakharkin brattsev and chapovskii j gen chem ussr 35 2149 1965 to yield 4 3 carboranylpropyl thiyl pyrimidine 2 ol the chloro derivative is obtained with pocl 3 through methods known in the literature reaction to the 2 thiol derivative with thioureau is likewise achieved through methods known in the literature 2 benzylthio 4 5 iodo 1 methylimidazole is prepared from 2 benzylthio 4 5 iodoimidazole hebner and scholz u s pat no 2 654 761 1951 with dimethyl sulfate this is reacted in tetrahydrofurane at 85 u00b0 c with an equimolar amount of butyl lithium and then tributylborate further steps and removal of the benzyl protecting group is carried out in analogy to 5 dihydroxyboryl 2 thiouracil 2 benzylthio 4 chloropyrimidine is reacted in dmf with sodium aminoundecahydrododecaborate nakagawa and aono chem pharm bull 24 778 1976 removal of the benzyl group is achieved as described for 5 dihydroxyboryl 2 thiouracil in an analagous manner 4 undecahydrododecaboranylthio pyrimidine 2 thiol is obtained upon reaction with disodium mercaptoundecahydrododecaborate n methyl thiosemicarbazide is reacted with 3 carboranyl acetyl chloride zakharkin chapovskii brattsev and stanko j gen chem ussr 36 892 1966 to n methyl n 34 b carboranyl acetyl thiosemicarbazine the reaction product is cyclized with naoh analogous to kroger sattler and beyer ann chem 643 128 1961 1 2 bis aminomethyl nidocarborane zakharkin and grebennikov izv akad nauk sssr ser.