ligand which will bind to lxr u03b2 comprising comparing the shape of a compound with the shape of the ligand binding cavity of lxr u03b2 as obtained from a crystal according to the invention and determining which amino acid or amino acids of the ligand binding domain interact with said compound in yet another aspect of the present invention there is provided a crystallized molecule or molecular complex comprising a binding pocket defined by the structure coordinates of human lxr u03b2 ligand binding domain amino acid residues 200 or a homologue of said molecule or molecular complex wherein said homologue has a root mean square deviation form the backbone atoms of said amino acids of not more than 1 5 u00e5 in a preferred embodiment of this aspect there is provided a crystallized molecule or molecular complex comprising a binding pocket defined by the structure coordinates of human lxr u03b2 ligand binding domain amino acid residues ser242 phe268 phe271 thr272 leu274 ala275 ser278 ile309 met312 leu313 glu315 thr316 arg319 ile327 phe329 leu330 tyr335 phe340 leu345 phe349 ile350 ile353 phe354 his435 gln438 val439 leu442 leu449 leu453 trp457 or a homologue of said molecule or molecular complex wherein said homologue has a root mean square deviation form the backbone atoms of said amino.