mmol was added under n 2 to a 20 u00b0 c solution of 52 5 mmol of a 1 6m hexanes solution of n buli and 45 ml of thf alternatively 52 5 mmol of a 1 0m solution of lin sime 3 2 in thf cyclohexane was added to 25 ml of thf under n 2 at 20 u00b0 c after 15 min the solution was cooled to 78 u00b0 c and 50 0 mmol of the appropriately substituted cyclohexanone from table 1 or commercially available in 50 ml of thf was added after 45 min 27 5 mmol of methyl dimethoxyacetate was added and the mixture was allowed to warm slowly to room temperature after stirring overnight the resulting solution was cooled to 0 u00b0 c and acidified to ph 3 4 with 2n aqueous hcl the mixture was diluted with et 2 o 200 ml and washed with water and brine after drying over na 2 so 4 the solution was concentrated to give the crude product which was purified by mplc table 2______________________________________ str16 com pound mp mass spectrumnumber r sub 2 u00b0 c m z mh meoh sup ______________________________________100 1 nap ch sub 2 oil 309101 2 clph ch sub 2 oil 293102 2 et bu oil 225103 2 nap ch sub 2 oil 309104 3.