30 12 0 lt 0 0000benign breast 29 10 0breast cancer 30 12 0 0 0001normal females 32 10 0pancreas cancer 30 16 6 0 100benign pancreas 13 10 7pancreas cancer 30 16 6 lt 0 0000normal 50 10 0ovarian cancer 24 10 2 0 010normal females 32 10 0melanoma 28 10 0 0 78normal 50 10 0______________________________________ sup 1 gail m h 1979 some statistical methods for evaluating immunodiagnostic tests in heberman r mcintire r eds immunodiagnosis of cancer part i new york marcel dekker pp 20 37 table ii______________________________________ sensi speci tivity ficity cut off______________________________________lung ca vs normal 40 84 10 0colorectal ca vs normal 40 94 12 9breast ca vs normal 60 88 11 0pancreatic ca vs normal 63 98 14 1ovarian ca vs normal 50 84 10 2breast ca vs benign breast 63 93 10 0pancreatic ca vs benign 100 0 10 0pancreas______________________________________ table iii______________________________________ancillary analysis median wilcoxoncomparison group n titer p value______________________________________metastases to liver colon ca 12 21 9 lt 0 0000no liver involvement colon ca 18 10 0 gt 2 metastatic sites breast ca 8 13 5 0 029 u2266 2 metastatic sites breast ca 22 10 5______________________________________ summarizing the above results significant increase in 47d10 antigen levels was found in all cancer groups except melanoma when compared with normal controls p lt 0 05 table i the assay failed to distinguish pancreatic cancer from benign pancreatic disease there was.