using 2 amino 3 methylbenzaldehyde and ethyl glycinate followed by hydrogenation over pd c a mixture of ethyl n 2 amino 5 iodobenzyl glycinate 3 34 g and cyanogen bromide 1 11 g was heated under reflux in ethanol 20 cm 3 for 18 hours a solution of sodium hydroxide 0 42 g in water 5 cm 3 was added to the cooled room temperature solution and the mixture was stirred for a further 2 hours the mixture was then filtered and the solid was washed with water 10 cm 3 and dried in vacuo a small portion of this material was chromatographed on silica merck mk 34 60 9385 34 trade mark eluting with chloroform methanol 19 1 combination and evaporation of the appropriate fractions afforded a solid which was triturated with isopropanol to give the title compound m p 323 u00b0 324 u00b0 analysis found c 38 3 h 2 7 n 13 2 calculated for c 10 h 8 in 3 o c 38 4 h 2 6 n 13 4 the following compounds were prepared similarly to the previous preparation using the appropriately substituted ethyl n 2 amino 5 iodobenzyl glycinate and cyanogen bromide as the starting materials ______________________________________ str28 prep analysis ara theoreticaltion form isolated in brackets no r r sup 1 r sup 2 and m p u00b0 c c h n______________________________________5 ch sub 3 h h free base 40 8 3 2 12 5 280 u00b0 40 4 3 1 12 8 6 h ch sub 3 h free base 40 7 3 2 12 7 289 90 u00b0 40 4 3 1 12 8 ______________________________________ iodine monochloride 28 9 g was added over 0 5 hours to a stirred solution.