z 813 mh 2 2 721 542 base mh 3 a solution of 423 mg 2 0 mmol of h ser t bu ome hcl 1 01 g 3 5 mmol of 3 phenoxycinnamyl bromide jackson w p islip p j kneen g pugh a wates p j j med chem 31 1988 499 u2013 500 and 0 87 ml 5 0 mmol 650 mg of diea in 6 ml of dmf was stirred under n 2 at room temperature for 20 h the mixture was partitioned between etoac and water and the organic layer was washed with water and brine after drying over na 2 so 4 the organic solution was concentrated to give 0 98 g of yellow oil the crude residue was purified by mplc using a solvent gradient ranging from 10 u2013 30 etoac hexanes to give two products the less polar product 168 mg 14 based on starting amino acid n n bis 3 phenoxycinnamyl ser t bu ome cpd 290 was isolated as a pale yellow oil 1 h nmr cdcl 3 300 mhz 1 15 s 9h 3 35 dd 2h j 7 14 5 hz 3 53 dd 2h j 5 5 14 5.