body weight only we found that the diagnosis of metabolic syndrome was dependent on five criteria glycemic index insulin resistance blood pressure hdl levels triglyceride levels and waist circumference adiposity patients who showed abnormal threshold levels of three of the five criteria were typically given the diagnosis of u201c metabolic syndrome u201d we studied the relationship of akt1 haplotypes with each of these five component measures and found that fasting glucose levels in males was most strongly associated with akt1 genotype using a dominant inheritance model u201c all males u201d and black males with the alleles identified herein showed significantly decreased fasting glucose levels chi 2 8 3 p 0 01 this suggests that akt1 plays a regulatory role in maintenance of glucose levels in the blood perhaps via insulin resistance measures of hyperglycemia and increased insulin resistance are generally acknowledged to be physiologically related and are considered key components of metabolic syndrome and type 2 diabetes the best measures of these parameters remain debated while fasting glucose is most commonly used homa fasting glucose u00d7 insulin oral glucose tolerance test and intravenous glucose tolerance test are often employed as well we had both fasting glucose and homa available in our health abc population and we tested the predictive power of these measures for metabolic syndrome diagnosis as well as systolic blood pressure and hdl levels table 2 correlation coefficients r 2 without statistical adjustment for covariance showed hdl levels to have the highest predictive power followed by.