0 7 u00b1 0 19 um 0 0026 u00b1 0 0005 um and 1 6 u00b1 0 23 um respectively and the therapeutic index are 7 8 3 4 9923 and 7 3 respectively 23 hydroxyl betulinic acid compounds zhangnan 5 zhangnan 7 and zhangnan 8 all have inhibition effect to hiv 1ada m in which zhangnan 7 has the strongest inhibition activity to hiv 1ada m and is significantly stronger than positive control compound sch c in addition the inhibition effect to hiv 1ada m has significant dose effect relationship with its concentration the compounds zhangnan 5 zhangnan 7 and zhangnan 8 and the salts of various forms thereof can be used as drug substance of anti aids drugs the formed salts are produced from reaction of derivatives and alkali alkali can be any forms of alkali which can be inorganic alkali such as sodium hydroxide potassium hydroxide and the like and can also be organic alkali such as alkali metal alkoxide and the like oral agent or injection agent of anti aids drugs can be made of the compounds zhangnan 5 zhangnan 7 and zhangnan 8 or the salts in various forms thereof with drug carrier and or excipient including corn oil sodium carboxymethylcellulose and the like 5 pharmacokinetics research.