pleckstrin homology ph and the catalytic kinase domain molecular modeling was carried out using a structure available in a protein databank pdb to represent the pleckstrin homology domain of human protein kinase b u03b1 isoform using mds 2 0 molecular design suite software available from vlife sciences technologies pvt ltd pune india previously 3 u2032 4 u2032 o substituted derivatives of isoflavones were developed as therapeutic agents against protein tyrosine kinase ptk and molecular modeling studies confirmed that isoflavonoids have the structural features important for binding to the sh2 domain of p56lck protein kinase west et al structure and bonding vol 76 page 1 1991 however the x ray crystal structure for the kinase domain of pkb u03b1 isoform was not available in the protein databank therefore the kinase domain of pkb u03b1 was modeled by using the cleaned and optimized x ray crystal structure of pkb u03b2 pdb code 1gzk as a template sequence identity 86 and similarity 94 with the u03b1 isoform the conformation analysis of genistein and its cu 2 conjugates fpa 124 to fpa 127 was carried out and conformers satisfying steric requirement of the each cavity were considered for docking the conformers were placed in the active site and resultant complex structures were then energy minimized using mmff94 force.