83 0 7 5 3 10 6 8 10 131 9 3 1 4 7 65 6 1 9 11 13 181 11 8 1 67 9 10 3 6 8 10 15 171 13 20 1 3 7 11 16 18 45 2 25 91 15 10 1 3 6 8 10 13 15 60 0 20______________________________________ lox a human melanoma cell line grown subcutaneously in nude mice was excised trypsinized to yield a single cell suspension using a metal grid with a 4 mm mesh red blood cells were lysed by incubation with 0 17 molar ammonium chloride at 4 u00b0 c for 20 minutes five million viable trypan blue negative cells made up in 0 1 ml of dulbecco modified eagles 39 medium dme were injected into the peritoneal cavity of a male athymic swiss nu nu mouse the control group and each treatment group consisted of 5 to 10 mice treatment was commenced the following day by intraperitoneal injection ten control mice received 0 25 ml of 2 dextrose on those days the treated groups were injected with the compounds of this invention the compounds of the general formulas i to ii used in this invention which were tested are listed in table 6 below and the results obtained are shown in.