inactivating agent can render the medicament unavailable through inactivation for example chemical inactivation or alteration of the receptor binding site of the medicament electrical inactivation or alteration of the receptor binding site of the medicament magnetic inactivation or alteration of the receptor binding site of the medicament mechanical inactivation or alteration of the receptor binding site of the medicament biounavailability physical unavailability loss of appeal of the medicament to the abuser such as for example an inactivating agent which creates an intolerably bad taste or an intolerable reaction such as extreme nausea or the like or something similar thereto one or more inactivating agent s may be used further if the medicament were an opioid the inactivating agent could be a chemical or denaturing agent that would alter residual opioid molecules in the dosage form and make them inactive the inactivating agent could be an opioid receptor that would bind the residual opioid into an insoluble ligand receptor complex the inactivating agent could also be an opioid receptor antagonist preferably with greater specificity and or affinity for the receptor than the opioid which would be isolated or delivered with the residual opioid upon misuse and compete with the residual opioid for the opioid receptor thereby defeating the purpose of misusing the opioid this would render the residual opioid useless in vivo the inactivating agent could also physically sequester the medicament such as for example in an impermeable microsphere or in a permanently bound matrix similarly the inactivating agent could be a non opioid with distressing or dysphoric properties if absorbed that made abuse unappealing the dosage form may preferably contain a detection material that is also released when the dosage form is tampered with.