cells to exit from the cell cycle would have useful applications in gene therapy of proliferative disorders such as cancer or psoriasis because human and mouse p53 proteins form complexes in cells the construct containing mouse p53as cdna is claimed for the purposes of gene expression in mammalian cells and nonmammalian cells for research purposes including human cells and for gene therapy in humans in addition a purified plasmid construct containing the human p53as homologue of mouse p53as defined by insertion of human intron 10 sequences into a sequence containing wt p53 dna as defined in original patent application ser no 08 100 486 is claimed for research purposes in mammalian and nonmammalian cells and for gene therapy in humans table 1 shows reactivities of antibodies against p53 proteins mouse p53 has 390 amino acids human p53 393 amino acids all antibodies are mouse monoclonals commercially available from oncogene science cambridge mass except apas rabbit polyclonal specific for p53as protein which was made in dr kulesz martin 39 s laboratory rpci sources oncogene science catalogue p 8 1992 vajtesek et al j of immunolog methods 151 237 244 1992 a wade evans a and jenkins j r embo j 4 699 706 1985.