bromide b with aryl boronic acid e gives a b unsaturated diethyl amide g which is compound no 1 as listed above and exemplified below in example 2 it should be noted that synthesis of this diethyl amide by such route may likely result in a in low yield possibly due to the thermal instability of aryl boronic acid e it was also noted during the development of the compounds of the present invention that the identification of diethyl amide g as a compound of interest i e compound no 1 3 4 1 2 diphenyl but 1 enyl phenyl n n diethyl acrylamide dictated the need for a more efficient synthesis for analog preparation accordingly it was found that horner emmons reaction of aldehyde d with phosphonate f gave diethyl amide g in significantly higher yield str7 additionally scheme c set forth above illustrates that the a b unsaturated diethyl amide g can be converted into a the thioamide h compound no 21 3 4 1 2 diphenyl but 1 enyl phenyl n n diethyl thioacrylamide with lawesson 39 s reagent b the saturated amide i compound no 2 3 4 1 2 diphenyl but 1 enyl phenyl n n diethyl propionamide by hydrogenation or c the cyclopropyl amide j compound no 3 2 4 1 2 diphenyl but 1 enyl phenyl cyclopropanecarboxylic acid diethylamide with the corey ylide referring to scheme d.