are carried out sc at least 2 hours after the first control threat the pretreatment time for each compound is 40 minutes rats are trained to press levers for food reward in operant chambers the schedule consists of alternations of four 4 minute unpunished periods on variable interval of 30 seconds signalled by chamber lights on and three 3 minute punished periods on fixed ratio 5 by footshock concomitant to food delivery signalled by chamber lights off the degree of footshock is adjusted for each rat to obtain approximately 80 to 90 suppression of responding in comparison with unpunished responding rats receive saline vehicle on training days the compounds of the instant invention are also expected to be useful in the treatment of pain and phobic disorders am j pain manag 5 7 9 1995 the compounds of the instant invention are also expected to be useful in treating the symptoms of manic acute or chronic single upside or recurring they are also expected to be useful in treating and or preventing bipolar disorder u s pat no 5 510 381 the compounds of the present invention can be prepared and administered in a wide variety of oral and parenteral dosage forms thus the compounds of the present invention can be administered by injection that is intravenously intramuscularly.