the mixture was placed under 45 psig hydrogen and shaken at ambient temperature the course of the reaction was followed by hydrogen uptake pressure drop the reaction was stopped after 7 4 h at which point 1 h nmr analysis indicated 79 4 conversion based on this data the conversion after 1 h was 22 1 after 2 h 37 7 after 3 h 50 0 after 4 h 59 3 after 5 h 66 6 after 6 h 72 5 and after 7 h 77 4 5 palladium on carbon 49 5 in water 218 mg 5 wt based on 3 hydroxypropionitrile was added to a parr pressure bottle water 3 21 g was added followed by diethylamine 2 14 g 29 3 mmol 1 0 equiv diethylamine hydrochloride 0 802 g 7 32 mmol 0 25 equiv was added followed by 3 hydroxypropionitrile 2 08 g 29 3 mmol the mixture was placed under 45 psig hydrogen and shaken at ambient temperature the reaction was stopped after 4 h and sampled and analyzed by 1 h nmr to indicate 69 conversion 1 h nmr dmso d 6 u03b4 ppm 3 45 t 2h j 6 3 hz 2 50 t 2h j 7 4 hz 2 44 q 4h j 7 2 hz 1 54 m 5 2h j 6 3 hz 0 95 t 6h j 7 1 hz 5 palladium on carbon 49 5 in water 218 mg 5 wt based on 3 hydroxypropionitrile was added to a parr pressure bottle water 3 21 g was added followed by diethylamine 2 68 g 36 6 mmol 1 25 equiv and 3 hydroxypropionitrile 2 08 g.