greatly reduced il 8 induction by the sample table 2 table 2______________________________________removal of pyrogens from ro water by claretox adsorbent lps eu ml il 8 pg ml samples lps eu ml after claretox il 8 pg ml after claretox______________________________________ro water 17 6 lt 0 005 39 5 1 4______________________________________ a column was packed with 9 ml of claretox resin at 3 ml min 50 ml 1 m naoh was pumped into the column and was allowed to sit in the column overnight the column and the tubings were rinsed with lal water to neutrality the column was perfused with dialysate at 3 ml min and fractions were collected periodically the endotoxin level in dialysate was 1 5 eu ml that was reduced below 0 01 eu ml by claretox fig7 the ro water line was attached to the inlet port of the deionizer column and water was passed through the two column apparatus deionizer plus claretox at 11 13 ml min continuously taking samples each day for endotoxin determination and conductivity measurements the ro water was continuously pumped through the system until endotoxin level in the claretox column effluent reached 0 25 eu ml fig3 it took 130 l of water to reach this breakthrough point this translates into 13 000 volumes of purified.