bisectional trisectional and quarter sectional fracture of the tablet for patient consumption each amount of active substance separated in this manner from the tablet then constitutes in itself a new separate dosage of a medicament and is thus governed by the same prescriptions regarding accuracy and permissible limits of dosage as in the case of the undivided tablet for e g a tablet with a circular horizontal cross section having two score lines disposed on the surface wherein the score lines are placed diametrically and perpendicular to each other such that the tablet may be fractured into equal quarter sections for consumption the present invention also provides high dose oral pharmaceutical composition of artemether and lumefantrine of the present invention comprising artemether in an amount of 40 mg and lumefantrine in an amount of 240 mg which may be bioequivalent to two tablets of coartem u00ae marketed by novartis the present invention also provides high dose oral pharmaceutical composition of artemether and lumefantrine of the present invention comprising artemether in an amount of 60 mg and lumefantrine in an amount of 360 mg which may be bioequivalent to three tablets of coartem u00ae marketed by novartis the present invention also provides high dose oral pharmaceutical composition of artemether and lumefantrine of the present invention comprising artemether in an amount of 80 mg and lumefantrine in an amount of 480 mg which.