42 7 49 m 2h 7 36 7 40 m 2h 7 28 7 35 m 2h 6 99 dd j 2 49 8 66 hz 1h 6 72 d j 8 80 hz 1h 4 95 s 2h 3 95 s 3h to compound 35 506 mg 1 07 mmol in meoh 30 ml was added 5m naoh 2 ml and the solution stirred at room temperature for 16 hours the mixture was acidified with 10 hcl and extracted with etoac u00d7 2 the combined organic layers were washed with brine dried over na 2 so 4 and concentrated in vacuo the crude product was recrystallized from minimal meoh and ch 2 cl 2 to yield compound 36 484 mg 98 1 h nmr 600 mhz dmso d 6 u03b4 13 01 br s 1h 10 57 s 1h 7 78 7 84 m 2h 7 62 7 67 m 1h 7 42 7 47 m 2h 7 37 7 42 m 2h 7 31 7 35 m 1h 7 27 7 31 m 2h 7 24 dd j 2 35 8 80 hz 1h 7 00 d j 8 80 hz 1h 4 87 s 2h to isochroman 3 g 22 4 mmol in xylene 30 ml was added seo 2 2 48 g 22 4 mmol and the mixture stirred at 140 u00b0 c for 20 hours and then additional seo 2 2 48 g 22 4 mmol was added and the.