1______________________________________ penetrationpenetration enhancer hrs 5 6 12 24______________________________________ 1 compound of example 8 16 1 28 2 49 1 2 compound of example 13 8 8 17 3 34 9 3 control 1 3 1 8 2 4______________________________________ the compounds of examples 8 was tested as penetration enhancers according to the procedure outlined under example 49 1 hydrocortisone in the formulations of example 49 was substituted by 1 5 fluorouracil the results are outlined in table 2 and clearly show that the compound of example 8 is superior to the control table 2______________________________________ penetrationpenetration enhancer hrs 6 12 24______________________________________ 1 compound of example 8 59 2 60 3 60 5 2 control 8 7 10 4 10 9______________________________________ an aerosol form of the formulation of example 51 is prepared by preparing the following mixture ______________________________________ formulation 25 freon 75 ______________________________________ freon is 75 25 freon 114 12 ______________________________________ ______________________________________clindamycin base 1 0stearyl alcohol u s p 12 0ethoxylated cholesterol 0 4synthetic spermaceti 7 5sorbitan monooleate 1 0polysorbate 80 u s p 3 04 decyl 2 trifluoromethyl 0 92 oxazolinesorbitol solution u s p 5 5sodium citrate 0 5chemoderm 844 0 2purified water 68 0______________________________________ ______________________________________ a b ______________________________________clindamycin base 1 0clindamycin phosphate acid 1 3 sodium hydroxide 0 077 1 m hydrochloric acid 2 27disodium edentate 2h2o 0 003 0 003fragrances 0 5 0 54 decyl 2 trifluoromethyl 1 0 1 02 oxazolinepurified water 20 0 17 73isopropanol 77 12 77 497______________________________________ these solutions are effective for the treatment of acne in humans this solution is effective for the treatment of otitis in domestic animals ______________________________________ ______________________________________paba 2 0benzyl alcohol 0 54 decyl 2 trifluoromethyl 1 02 oxazolinepolyethylene glycol 10 0isopropyl lanolate 3 0lantrol 1 0acetylated lanolin 0 5c12 c15 benzoate 5 0diisopropyl adipate 2 0cetyl alcohol 1 0veegum.