plasticizer the blend was granulated and dried at 40 50 u00b0 c for 3 hours then it was screened and mixed with 2 50 g of glidant the blend was mixed to homogeneity and 7 50 g of lubricant was added the final blend was tabletted using biconcaves 9 25 mm diameter punches to form uncoated cores core weight 420 0 mg hardness from 8 to 12 kp a first composition to cover the cores was prepared as follows 40 85 g of cellulose ester and 2 15 g of plasticizer was added to 495 0 ml of a blend of organic solvents this polymer mixture was sprayed onto the tablets in a conventional pan coater to obtain film coated tablets whose membrane coating weighed approximately 43 0 mg a 0 50 mm hole was laser drilled through the coating in one face of the tablet the second coating was prepared by mixing 3 90 g of water soluble polymer 3 50 g of opaquant 12 58 g of talc and 18 00 mg of colorant in isopropyl alcohol this polymer mixture was sprayed onto the tablets in a conventional pan coater to obtain film coated tablets whose membrane coating weighed approximately 20 mg the third coating was prepared by mixing 10 00 g of loratadine 30 00 g of film forming polymer 5 40 g of plasticizer 9 60 g of water soluble polymer disintegrant and.