at least partially circumscribe the balloon 72 as shown in fig1 b alternatively the balloon 72 may be a cryoablation device with a tip and or balloon electrodes 74 being used in gradient generating mode still further the balloon 72 electrodes 74 and or the ablation device 14 may be coated with a layer of tsa 26 as shown and described in fig4 a and 4b referring now to fig1 a and 11b a first exemplary embodiment of an ablation device 14 used in association with a second device 56 for the application of tsa to tissue 10 is shown as shown in fig1 a the ablation device 14 may have a distal end 46 including one or more ablation elements 12 the second device 56 may be any device capable of applying tsa 26 to the target tissue 10 for example the second device 56 may be a catheter type device or swab having a distal end 58 coated with a layer of tsa 26 as shown in fig1 a a device having a spray nozzle as shown in fig7 and 11b or dropper apparatus in fluid communication with a tsa source such as the tsa reservoir 40 or a hypodermic.