to the solution at concentrations shown in table 3 below and dissolved completely 2 5 g of pemetrexed was slowly added to the resultant and the mixed solution was stirred until the solution became transparent then its ph was adjusted to that shown in table 3 using an aqueous solution of hydrochloric acid or sodium hydroxide the solution was aseptically filtered via a sterile 0 22 u03bcm filter membrane filter in a clean room the thus obtained solution was filled into a sealable container being washed and sterile after purging using nitrogen until the oxygen gas content within the headspace to those shown in table 3 the compositions and oxygen gas content within the headspace of the obtained pemetrexed comprising solutions for injection are shown in table 3 below pemetrexed comprising solutions were prepared according to the compositions and contents in table 4 below in the same manner as in example 1 in comparative example 1 the solution was prepared using only the water for injection as a carrier without adding any antioxidant stability tests were performed for compositions prepared in examples 1 to 20 and comparative examples 1 to 17 under stress testing conditions 60 u00b0 c 80 for four weeks among them for compositions prepared in example 11 and comparative examples 1 12 and 14 stability tests were performed under accelerated conditions 40 u00b0 c 70 for four months as well evaluation of stability was performed by measuring the content of pemetrexed remaining in the aqueous solution and the content of impurities via a high performance liquid chromatographic hplc method under conditions described in table 7 below additionally among the pemetrexed comprising liquid formulations for injection prepared above the images showing the comparative features in stability stress testing conditions.