when topically applied for the treatment of tumors and cancers particularly for the treatment of viral or cancerous skin disorders and skin manifestations thereof interferon is usefully employed in these compositions in combination with the antitumor agent antitumor agents which are useful include interleukin such as interleukin ii tumor necrosis factor target cell lysis factor and carcino breaking factor these compositions are especially usefully applied by topical application to the skin manifestation of the viral or cancerous skin disorder application_number US 83066286 A description the compositions of one embodiment of this subject invention contains effective amounts of tumor necrosis factor tnf human interferon an antiviral surface active agent and a physiologically acceptable carrier the tnf may be natural or synthetic tnf i e tnf produced by recombinant dna technology the compositions may also contain any natural or synthetic of the known varieties or sub varieties of human interferon thus the compositions may contain natural and or synthetic tnf and natural and or synthetic alpha or human leukocyte interferon and or beta or fibroblast interferon and or gamma or immune interferon an effective dose of tnf for treatment in accordance with the practices of the subject invention would be about 10 2 to 10 8 iu more or less an effective dosage of human interferon when present in the compositions in accordance with the practices of the subject invention would be about 10 2 to 10 8.