219g gt t and thbd ala455val were 1 89 1 01 3 57 and 2 79 1 04 7 52 respectively the c statistic for the final clinicogenomic model was 0 707 compared with 0 657 for the clinical covariate model suggesting improved discriminatory accuracy fig7 survival analyses by apoe and thbd genotype are displayed in fig8 and 9 the resulting independent hazard ratios 95 confidence intervals for long term survival adjusted for baseline logistic euroscore and cardiopulmonary bypass duration are 1 96 1 06 3 70 and 2 63 1 04 6 62 for the polymorphisms within apoe and thbd respectively see also table 4 while several models have been developed to estimate mortality risk following cardiac surgery they are limited in their ability to predict death for specific individuals from a prospective cohort of patients undergoing cabg with cpb two genetic polymorphisms were found to be associated with altered long term mortality these genes may represent new targets for therapies aimed at reducing long term mortality after cabg surgery furthermore addition of genetic information resulted in improved discriminatory ability of the predictive model providing better information for patients and providers evaluating the risks and benefits of cabg surgery apolipoprotein e plays a critical role in lipid metabolism and in the pathogenesis of atherosclerosis the u2212 219g gt t polymorphisms lies within the regulatory region of the apoe gene and affects circulating plasma apolipoprotein e levels through differential binding of nuclear proteins artiga et al febs lett 421.