of anagrelide with uk 37 248 01 is clearly superior to either drug along at several concentrations of collagen ______________________________________1st addition 2nd addition extent of 1 min before 0 5 min before collagen aggregation______________________________________ 2 u03bcl 49 5 u03bcl 54uk 37 248 01 anagrelide 2 u03bcl 0 40 u03bcm 10 u03bcm uk 37 2481 anagrelide 5 u03bcl 3 40 u03bcm 10 u03bcm uk 37 2481 anagrelide 10 u03bcl 17 40 u03bcm 10 u03bcm uk 37 248 01 anagrelide 20 u03bcl 24 40 u03bcm 10 u03bcm uk 37 248 01 anagrelide 50 u03bcl 39 40 u03bcm 10 u03bcm anagrelide 2 u03bcl 8 10 u03bcm anagrelide 5 u03bcl 25 10 u03bcm anagrelide 10 u03bcl 45 10 u03bcm uk 37 248 01 5 u03bcl 53 200 u03bcm ______________________________________ this example using prp obtained from a different donor illustrates that the effectiveness of uk 37 248 01 is markedly increased by a class of 34 camp inhibitor 34 other than the quinazolinone anagrelide using the pyrimidopyrimidine derivative ra233 ______________________________________1st addition 2nd addition extent of 1 min before 0 5 min before collagen aggregation______________________________________ 5 u03bcl 45uk 37 248 01 5 u03bcl 38 20 u03bcm ra233 10 u03bcm 5 u03bcl 31uk 37 248 01 ra233 10 u03bcm 5 u03bcl 1 20 u03bcm ______________________________________ this example using prp obtained from yet another donor illustrates that the effectiveness of several different thromboxane synthesis inhibitors uk 37 248 01 imidazole methyl imidazole and nicotine are enhanced by different 34 camp phosphodiesterase inhibitors 34 including anagrelide papaverine and isobutyl methylxanthine ibmx ______________________________________1st addition 2nd addition extent of 1 min before 0 5.