a direct detection of nucleic acids in crude lysate in a multiplex format without the requirements for nucleic acids extraction and amplification such an improvement is likely to change the practice of genotyping and gene expression profiling done in a clinic setting another application is an ultrasensitive eliza assay in a multiplex format application_number US 99182509 A description in general the probes of an array capture and bind the analyte to be detected probe capture or target binding moieties include nucleic acids polynucleotides proteins peptide nucleic acids small molecules and a wide variety of biomolecules target binding probe moieties include antibodies in one example streptavadin is used to detect a biotin labeled molecule in one aspect this invention embodies increased numbers of analytes within each point or spot of the array the increased number of analytes per spot is achieved by compositions of mesh probes which can capture enhanced numbers of analyte moieties in one embodiment meshed polymers are formed from a polymer linked to chemical or biomolecules where the chemical or biomolecules include a probe or probes thereby forming a mesh probes the chemical or biomolecules containing the probe or probes are coupled to the polymer by covalent bonds or by non covalent chemical interactions such as ionic interactions or weak binding forces the polymer may be a linear or branched polymer such as a linear or branched polysaccharide or oligonucleotide for example the polymer can be a solid gel or amorphous composition in the form of layers beads discs or mixtures thereof and can be homogeneous or heterogeneous linear or branched side chain branched branched.