solution 0 1 m in toluene the reaction was stirred under nitrogen on an oil bath 82 u00b0 c for 5 hours giving a clear dark green solution after the removal of solvent on high vacuum the greenish residue was washed with freshly distilled diethyl ether 3 u00d7 5 ml it was then redissolved in 20 ml 2 propanol and divided into ten equal parts to each part 2 ml of the catalyst solution was introduced 0 4 mmol of a ketone substrate the reaction mixture was stirred at rt for a brief period before 0 1 ml of naopr i solution 0 1 m in 2 propanol was finally added in one portion the ten reaction ampuls were placed in an autoclave and charged with hydrogen gas initial pressure 5 atm the reactions were allowed to stir at rt overnight a small portion of each reaction mixture was passed through a silica gel plug then eluted with diethyl ether both reaction conversion and enantiomeric excess were then determined by gc analysis 1 reviews a zassinovich g mestroni g gladiali s chem rev 1992 92 1051 b de graauw c f peters j a van bekkum h huskens j synthesis 1994 1007 2 a jiang y jiang q zhu g zhang x tetrahedron lett 1997 38 215 b jiang y jiang q zhu g zhang x tetrahedron lett 1997 38 6565 c jiang q z van plew d murtuza s zhang x tetrahedron lett 1996 37 797 d sammakia t stangeland e l j org chem 1997 62 6104 e evans d a nelson s g gagn u00e9.