that do not present the accumulation for example cells expressing high levels of nucleolin on the plasma membrane of the cell may be selected due changes in the stiffness and deformability of the cell as used herein u201c selectively kill or induce apoptosis u201d means that more of the cells which are the target of the killing or inducing apoptosis are so affected as compared to other cell subject to the same exposure ultrasound devices can be used according to practices well known to those skilled in the art to destroy cells by vibrational techniques for example u s pat no 5 601 526 1997 and international publication no wo2009 143411 2009 ultrasound parameters such as frequency power and pulsation can be screened for effectiveness in selectively destroying the targeted cells differential destruction or inducement of apoptosis may be by selection of the stiffer cells or by selection of the cells by their resonant frequencies ultrasound as described above can be applied to a subject with monitoring to determine that inflammatory responses such as fever or swelling do not exceed limits well known to be safe this process can be repeated at intervals to maintain a level of therapeutic benefit evaluation of improvement or maintenance of a desired result can be used to direct the frequency of reapplication of ultrasound according to the present invention the application.