mice respectively were found to be igg positive when analyzing sera collected just before challenge while 5 and 7 out of 10 mice respectively were found to be iga positive at least in one of the vaginal washes collected every weeks from boosting immunisation to challenge infection did not boost the momp specific iga response as shown by analysis performed one week after challenge 0118 table 7 rmomp igg iga positive n mean group no geometric mice nber of immunisation infection mean titer vaginal fertile newborn schedule serum washes mice per mouse g1 negative lt 100 nd 1 9 0 2 ctrl u2212 sc sc dq 3d u2212 mpl dq 3d u2212 mpl infected g2 positive ctrl 9000 nd 8 8 6 rmomp l2 sc sc dq 3d u2212 mpl dq 3d u2212 mpl sham infected g3 473 7 10 10 10 9 1 rmomp l2 in in on the 3 mlt mlt positive infected mice only g4 u2212 nd nd 4 10 2 1 in in ct ct infected g5 lt 100 5 10 6 8 3 5 rmomp l2 in in ct ct infected g6 lt 100 0 10 5 8 4 9 rmomp in in ct ct infected when compared with the positive control sham infected group fertility in the negative control group was nearly completely abolished indicating the specific effect of the chlamydial infection fertility of the mucosally treated groups revealed that immunisation with rmompf or rmompl2 combined with ct gave similar level of protection 63 or 75 respectively of the f and 81 or 58 of the n values recorded in the positive control group immunisation with rmompl2 combined.