4 hydroxy derivative is refluxed for several hours with a phosphorus halide like phosphorus oxychloride to obtain the intermediate of formula str7 the products of formula i are then produced from the compounds of formula v with the appropriate amine of the formula str8 this reaction is effected by treating the reactants in an autoclave at elevated temperatures according to a modification of the foregoing procedure a product of formula i wherein r 1 is hydrogen may be produced by this modification a 5 aminopyrazole of formula ii wherein r 1 is a heteromethyl group is used having the formula str9 r 6 represents a heterocyclic nucleus like furyl pyridyl or the like this material is processed as described above to get a compound of the formula str10 at this point the compound of formula ia is oxidized with an oxidizing agent like selenium dioxide in a high boiling solvent like diethyleneglycol dimethyl ether at about 160 u00b0 c this yields a compound of formula i wherein r 1 is hydrogen the compounds of formula i form salts which are also part of this invention the salts include acid addition salts particularly the non toxic physiologically acceptable members the bases of formula i form salts by reaction with a variety of inorganic and organic acids providing acid addition salts including for example hydrohalides especially hydrochloride and hydrobromide sulfate nitrate borate phosphate oxalate tartrate malate citrate acetate ascorbate succinate benzenesulfonate mthanesulfonate cyclohexanesulfamate and toluenesulfonate the acid addition salts frequently provide a convenient.