there is no effective treatment outside the honey production season both the hive 39 s frames and box drawers contaminated with spores are stored until next season without being disinfected becoming the source of infection at the start of the new production season hence the relevant biocide treatment with a composition with a concentration range capable of removing bacteria along with fungal spores the concentration range in the composition can also be expressed not referring to the extract but to the main metabolite oleuropeia in that case the composition has a concentration range for oleuropein of 0 0004 to 16 mg ml 0 02 to 12 mg ml from 0 02 to 0 032 mg ml 0 04 to 0 8 mg ml 0 8 to 4 mg ml 0 8 to 8 mg ml and 0 8 to 16 mg ml despite these calculations of the composition 39 s concentration based on the major metabolite of the water soluble olea europaea extract it is important to stress the possible synergistic importance and biocide activity within the composition of the invention with the aqueous extract of the olea europaea 39 s leaves which can have other metabolites present in lower proportions within the extract the biocide composition of the invention has the ability to control pests caused by.