the active ingredient a thickener such as hydroxymethylcellulose hydroxypropylmethylcellulose methylcellulose polyvinylpyrrolidone or the like to improve the retention of the medicament in the conjunctival sac the compounds are preferably formulated as topical ophthalmic suspensions or solutions with a ph of about 4 5 to 8 0 the compounds will normally be contained in these formulations in an amount of 0 1 to 10 by weight but preferably in an amount of 0 25 to 5 0 by weight thus for topical presentation these formulations would be delivered to the surface of a mammal 39 s eye 1 to 4 times a day according to the routine discretion of a skilled clinician the following examples which are in no way limiting illustrate the preparation of selected examples of the compounds of the present invention the compound set forth in example 1 represents the preferred thiophene sulfonamide to a solution of 3 1 3 dioxan 2 yl thiophene 3 6 g 23 mmol in dry thf 40 ml at 78 u00b0 c was added dropwise n butyllithium 2 5m in hexane 10 15 ml 25 mmol after stirring at 78 u00b0 c for 1 h a stream of sulfur dioxide was passed through the surface of the mixture for.