u00b1 13 166 7 u00b1 12 231 5 u00b1 57dose mg u00b7 kg sup 1 90 90 90 100 100 80 availability 100 89 2 82 7 87 2 89 2 154 8__________________________________________________________________________ sup a practical auc was calculated using the trapezoidal method the remaining area after the last observation was calculated according to wagner using ctn kel sup 1 area 24h sup b theoretical auc was evaluated on the fitted curve by the equations auc a u03b1 b u03b2 for the intravenous administration auc co ke for the extravascular administration table 5__________________________________________________________________________extent of availability of alclofenac after different routes ofadministration usingintravenous administration as reference __________________________________________________________________________ auc o u2192 4h i v p o acid p o lysine f lys vs acid__________________________________________________________________________practical aucmcg u00b7 min u00b7 l sup 1 u00b1 s e m 55 85 u00b1 2 3 23 69 u00b1 1 5 32 45 u00b1 2 dose mg u00b7 kg sup 1 90 90 90 availability 100 42 4 58 12 lt 0 01__________________________________________________________________________ auc o u2192 2h i v rectal acid rectal lys f lys vs acid__________________________________________________________________________practical aucmcg u00b7 min u00b7 l sup 1 u00b1 s e m 33 15 u00b1 1 30 6 u00b1 1 7 35 23 u00b1 2 6 dose mg u00b7 kg sup 1 90 100 100 availability 100 83 24 95 65 ns__________________________________________________________________________ taking into account also the chemical physical characteristics of alclofenac lysine salt it is be considered to be appropriate for preparations intended for intravenous use its appropriateness for forms to be administered per os.