gpr40 mice fig5 a c e g shows the expression of factors involved in glucose sensing and proinsulin processing is perturbed in wild type mice fig5 b d f h shows the expression of factors involved in glucose sensing and proinsulin processing is perturbed in ipf1 gpr40 mice fig6 a shows insulin radio immune assay ria of total pancreatic protein extracts in wild type and ipf1 gpr40 mice fig6 b shows quantitative real time pcr of insulin mrna from isolated islet cdna of wild type and ipf1 gpr40 mice fig7 a shows the glucose tolerance test of ipf1 gpr40 and wild type mice fig7 b shows the insulin secretion in response to glucose challenge of ipf1 gpr40 and wild type mice fig8 a b shows impaired insulin secretion in ipf1 gpr40 transgenic mice where the serum insulin levels were determined in wild type and ipf1 gpr40 mice after intraperitoneal injection of glucose into over night fasted animals several diseases could be treated by compounds which interact with the gpr40 receptor and in order to investigate the function of gpr40 in vivo the inventors have generated transgenic mice carrying over expressing gpr40 u03b2 cells under the control of the ipf1 pdx1 promoter apelqvist 1997 see fig1 this animal model could be used for studies of type 2 diabetes other animal models could be developed in the same approach for the studies of other diseases the resulting transgenic mice carrying over expressing gpr40 u03b2 cells were born alive and appeared initially healthy but developed diabetes with age see table 1 suggesting that forced expression of gpr40 in adult u03b2 cells perturb u03b2 cell function the results as described below from the transgenic mice point to new ways in which manipulation of the expression of the gpr40 lead to diabetes and could be.