clin pharmacol ther 63 580 93 in this manner such peptides can treat both pain and inflammation other analgesic peptides can be present at the carboxy terminus of the peptide following a cleavage site including endomorphin 1 endomorphin 2 nocistatin dalargin lupron and substance p as described in greater detail below various analgesic peptides and compounds can be covalently linked to or used in combination therapy with the therapeutic peptides described herein in the human body an inactive form of chymotrypsin chymotrypsinogen is produced in the pancreas when this inactive enzyme reaches the small intestine it is converted to active chymotrypsin by the excision of two di peptides active chymotrypsin will cleave peptides at the peptide bond on the carboxy terminal side of trp tyr or phe the presence of active chymotrypsin in the intestinal tract will lead to cleavage of certain of the peptides of the invention having an appropriately positioned chymotrypsin cleavage site certain of the peptides of the invention include a trp tyr or phe immediately followed by a carboxy terminal analgesic peptide it is expected that chymotrypsin cleavage will release the analgesic peptide from peptide of the invention having an appropriately positioned chymotrypsin cleavage site as the peptide passes through the.