inhibitor in this example is a proton pump inhibitor omeprazole which raises the ph of the gastrointestinal tract to above 4 the typical effective amount of omeprazole in the dosage form may vary from 5 mg to 50 mg the film coat is applied by conventional pan coating technology and the weight of film coat may vary from 4 to 8 of the core tablet weight other ingredients are plasticizers such as triethyl citrate dibutyl phthalate anti adhering agents such as talc lubricating ingredients such as magnesium stearate opacifiers such as titanium dioxide and ammonium hydroxide to adjust the ph of the dispersion the film coating is thin and rapidly releases omeprazole for absorption therefore omeprazole is released first and then the core erodes and releases naproxen sodium naproxen sodium 50 microcrystalline cellulose and povidone are dry mixed and wet granulated in an appropriate granulator with sufficient purified water the wet granules are dried milled and blended with the remaining 50 microcrystalline cellulose talc and magnesium stearate the final granule blend is compressed into tablets opadry clear is added slowly to purified water and mixing is continued until opadry is fully dispersed the solution is sprayed on to the tablet cores in a conventional coating pan until the proper amount of opadry clear is deposited on the tablets methacrylic acid copolymer triethyl citrate and talc are dissolved in a mixture of isopropyl alcohol and water the solution is then sprayed on to the tablet bed in a proper coating equipment a sample of the tablets is tested for gastric resistance and the coating is stopped if the tablets pass the test omeprazole is dissolved in a purified water and isopropyl alcohol.