addition the mixture was stirred at 15 u00b0 c 20 u00b0 c for 1 hr poured into a solution prepared separately by dissolving p hydroxypropiophenone 150 g in ethyl acetate 500 ml and triethylamine 101 g and by heating the obtained solution to 35 u00b0 c 40 u00b0 c which temperature was maintained during the dropwise addition and for one or two more hours addition of deionized water 1000 ml gave two phases the organic phase was washed with deionized water 500 ml and evaporated to a thick oil which was crystallized with acetonitrile 1500 ml by heating and subsequent cooling to 15 u00b0 c the precipitate was separated by filtration and washed thoroughly with acetonitrile drying yielded 300 g of ursodeoxycholic acid ester having the following characteristics ammonolysis taurine 105 g was dissolved in deionized water 525 ml and sodium hydroxide pearls 33 5 g the solution was added with sec butyl alcohol 300 ml and phenol ester 300 g obtained as described above the solution was refluxed for 5 hrs ethyl acetate 1000 g was added and phases were allowed to separate the alkaline aqueous phase after the remaining solvent is distilled was added with deionized water 300.