via the alimentary canal or in the form of creams ointments patches or similar vehicles suitable for transdermal applications doses of from 0 1 u03bcg to 10 u03bcg per day of the compounds are appropriate for treatment purposes such doses being adjusted according to the disease to be treated its severity and the response of the subject as is well understood in the art since the compound exhibits specificity of action each may be suitably administered alone or together with graded doses of another active vitamin d compound u2014 e g 1 u03b1 hydroxyvitamin d 2 or d 3 or 1 u03b1 25 dihydroxyvitamin d 3 u2014 in situations where different degrees of bone mineral mobilization and calcium transport stimulation is found to be advantageous compositions for use in the above mentioned treatment of psoriasis and other malignancies comprise an effective amount of the 2 methylene 20 s 19 nor vitamin d compound as defined by the above formula i as the active ingredient and a suitable carrier an effective amount of such compound for use in accordance with this invention is from about 0 01 u03bcg to about 50 u03bcg per gm of composition and may be administered topically transdermally orally or parenterally in dosages of from about 0 1 u03bcg day to about 10 u03bcg day the compound may be formulated as creams lotions ointments topical patches pills capsules or tablets or in liquid form as solutions emulsions dispersions or suspensions in pharmaceutically innocuous and acceptable solvent or oils and such preparations may contain in addition.