animal which received the vector rojas martinez a wyde p r montgomery calif chen s h woo s l c and aguilar cordova e distribution toxicity and lack of replication of an e1a recombinant adenoviral vector after systemic delivery in the cotton rat cancer gene ther 1998 y tongchuan h shibin z luis t jian y kenneth w and vogelstein berth a simplified system for generating recombinant adenoviruses proc natl acad sci usa vol 95 2509 2514 march 1998 a large body of data has been obtained that shows that after the i v administration of adenoviruses in healthy animals the main target cells were hepatocytes this has been observed in mice rabbits dogs and primates zern a m and kresina t f hepatic drug delivery and gene therapy hepatology 1997 vol 25 no 2 484 491 but not in cirrhotic rats probably the injection in portal vein could be more efficient to get to the target cells in the liver providing them a favorable innoculum of viral particles to the entire liver before being diluted into the bloodstream this route is efficient but it has the disadvantage that it requires a laparotomy on the other hand peritoneal administration is a faster and simpler infusion but it does not promote.