about 2 mg kg to 20 mg kg efficacy is defined as the modification of calcium or other ion transport across the cell membrane of host cells from the level of ion transport prior to the administration of the therapeutic agent table ii______________________________________tissue diversity of ligand activated receptor operated calciumchannels in mammalian cells partial list cell tissue agonist examples ______________________________________human t lymphocyte pha antibodies to cd2 cd3 and t cell receptor epitopeshuman b lymphocyte anti ig antibodies phahuman mast cell histaminehuman platelet thrombin adpvascular smooth muscle norepinephrine pdgf endothelin 1 histamine vasopressin angiotensinileum smooth muscle acetylcholinehuman a172 glioma cell bradykinin pdgfvascular endothelium thrombin histamine edrf nitric oxidehepatocyte vasopressinlacrimal acinar cell acetylcholineneutrophil fmlpj774 macrophage atpneural cells neurotransmitters endothelin 1 endothelin 3bronchial smooth muscle endothelin 1glomerular mesangial cells endothelinparotid cell muscarinic agonistshuman glioma endothelin______________________________________ pha phytohemaglutinin ig immunoglobulin fmlp formylmethionyl leucyl phenylalanine atp adenosine triphosphate edrf endotheliumderived relaxing factor adp adenosine diphosphate a effect of ciglitazone on the receptor operated calcium channel agonist induced ca 2 i signal the a172 human glioblastoma cell line was chosen to test the above stated hypothesis for three reasons first the effects of pdgf on ca 2 i in a172 cells has been studied in detail second the a172 cell does not contain voltage sensitive calcium channels third pdgf was chosen for its diverse cellular effects including vasoconstriction chemotaxis and.