adapalene retinol hydroquinone kojic acid a growth factor echinacea an antibiotic an antifungal an antiviral a bleaching agent an alpha hydroxy acid a beta hydroxy acid salicylic acid antioxidant triad compound a seaweed derivative a salt water derivative algae an antioxidant a phytoanthocyanin a phytonutrient plankton a botanical product a herbaceous product a hormone an enzyme a mineral a genetically engineered substance a cofactor a catalyst an antiaging substance insulin trace elements including ionic calcium magnesium etc minerals minoxidil a dye a natural or synthetic melanin a metalloproteinase inhibitor proline hydroxyproline an anesthetic substance chlorophyll bacteriochlorophyll copper chlorophyllin chloroplasts carotenoids phycobilin rhodopsin anthocyanin and derivatives subcomponents immunological complexes and antibodies directed towards any component of the target skin structure or apparatus and analogs of the above items both natural and synthetic as well as combinations thereof preferred among compositions which may be prepared in suitable form for mechanical microderm abrasion are those selected from naturally occurring chlorophyll containing compounds carotenoid containing compounds phyocobilin compounds indocyanine green methylene blue rose bengal vitamin c vitamin e vitamin d vitamin a vitamin k vitamin f retin a tretinoin adapalene retinol hydroquinone kojic acid a growth factor echinacea an antibiotic an antifungal an antiviral a bleaching agent an alpha hydroxy acid a beta hydroxy acid salicylic acid antioxidant triad compound a seaweed derivative a salt water derivative algae an antioxidant a phytoanthocyanin a phytonutrient plankton a botanical product a herbaceous product a hormone an enzyme a mineral a cofactor an antiaging substance insulin minoxidil lycopene a natural or synthetic melanin a metalloproteinase inhibitor proline hydroxyproline an anesthetic chlorophyll bacteriochlorophyll copper chlorophyllin chloroplasts carotenoids phycobilin rhodopsin anthocyanin inhibitors of ornithine decarboxylase inhibitors.