combination use includes administering all active ingredients in one formulation for example a tablet capsule feed stuff or liquid containing a compound of formula i and one or more said other agents administering each ingredient in a separate formulation and combinations thereof when one or more of a compound of formula i or said other agent s is contained in a separate formulation any order of administration as well as any interval between the administration of the active ingredients are within the meaning of co administration or combination use agents that may be co administered or used in combination with compounds of formula i include any that are used in the treatment or prevention of human or animal diseases or conditions or used in agricultural applications or for pest control in a preferred embodiment the co administered agents are used in veterinary medicine particularly those used in domesticated animals such as dogs and cats or other companion animals examples of other agents that may be co administered with compounds of formula i are provided below it is to be understood that the specific agents enumerated are illustrative only and are not meant to be restrictive in any manner accordingly compounds of the present invention may be co administered or used in combination with anthelmintic agents these anthelmintic agents are meant to include but not be restricted to compounds selected from the avermectin and milbemycin class of compounds such as ivermectin avermectin abamectin emamectin eprinamectin doramectin milbemycin derivatives described in epo 357460 epo 444964 and epo.