each dish contains a known amount of test compound the surfaces of the solidified agar plates are then inoculated with the test culture by streaking the test culture on the surface of the plate with a standardized loop that has been dipped in the inoculum and incubated at room temperature for 24 hours the mic values in table 1 are expressed in mcg ml table 1__________________________________________________________________________ staph staph s pyo entero escher kleb past pseudo prot prot salm d compd aureus aureus genes coccus coli pneum mult aerugi vulg mira typhi pneumon of ex 45 smith c 203 89 juhl 8045 10544 bmh no 10 abb jj fin 9 ed 6301__________________________________________________________________________1 12 5 12 5 12 5 25 25 12 5 1 56 gt 100 6 2 6 2 6 2 252 12 5 12 5 3 1 6 2 25 3 1 0 78 gt 100 3 1 6 2 3 1 12 53 6 2 3 1 3 1 6 2 6 2 1 56 0 35 50 1 56 3 1 1 56 6 2__________________________________________________________________________ as shown in table 1 the compounds of the present invention exhibit valuable bacteriostatic properties and are consequently useful in pharmaceutical compositions the compounds of this invention also exhibit very low oral and subcutaneous toxicities and produce generally the same antibiotic activities in vivo as chelocardin in addition to the excellent bacteriostatic properties of the new compounds they also show a surprising physical characteristic they are more soluble in water than chelocardin and therefore the new compounds distinguish favorably over chelocardin itself the excellent solubility makes the new compounds particularly suitable for parenteral solutions which can easily be prepared by simply dissolving the new chelocardin derivatives.