form is a physiological saline solution containing the peptide which solution is administered to provide a daily dose in the range of about 0 01 to 0 05 mg kg of body weight although the invention has been described with regard to its preferred embodiments it should be understood that changes and modifications obvious to one having the ordinary skill in this art may be made without departing from the scope of the invention which is set forth in the claims which are appended thereto substitutions known in the art which do not significantly detract from its effectiveness may be employed in the invention the compounds of this invention exhibit powerful effect on gonadotropin release by the pituitary bind to tumor cell membranes and inhibit 3 h thymidine incorporation into dna in cell cultures ability of compounds to influence lh release in vitro is assayed by using a superfused rat pituitary cell system s vigh and a v schally peptides 5 suppl 1 241 247 1984 v csernus and a v schally in neuroendocrine research methods ed b greenstein harwood academic publishers london 1990 lhrh inhibiting effect of peptides is assayed as follows each peptide is perfused through the cells for 9 min 3 ml perfusate at 1 nm immediately after that a mixture containing the same concentration of.