made from thiourea 9 2 g 0 12 mole and 2 bromo 4 4 dimethylcyclohexanone 22 6 g 0 11 mole in 100 ml of ethanol according to the method of example 6 thiourea 16 7 g 0 22 mole 1 bromo 3 methyl 2 pentanone 36 g 0 2 mole and 100 ml of ethanol were combined and heated to reflux for 5 hours aqueous potassium hydroxide 3 n 100 ml was added and reflux continued for an additional 0 5 hour the reaction mixture was cooled acidified with hydrochloric acid and nonbasic impurities extracted away with ether the aqueous phase was made basic with ammonium hydroxide and the product extracted into ether following back wash with water and drying over anhydrous sodium sulfate the ether was stripped to yield 10 g of 2 amino 4 2 butyl thiazole as a dark brown viscous oil thiourea 11 2 g 0 147 mole was slurried in 150 ml of ethanol and heated to reflux to yield a clear solution under continued reflux 2 bromocyclooctanone 27 6 g 0 134 mole dissolved in 50 ml of ethanol was added over 15 minutes reflux was continued for 4 hours a minor amount of precipitate which occurred during reflux was removed by filtration as was a further precipitate which occurred on cooling the mother liquor was stripped to a semi solid which was taken into 225 ml of water in divided portions the resulting aqueous solution was made basic with excess concentrated ammonium hydroxide and the product extracted into 200 ml of methylene chloride the organic layer was back washed with water then washed with saturated sodium chloride dried over anhydrous magnesium sulfate filtered and stripped to.