contrast to the position with untreated lenses where the advancing angle remains elevated throughout the wearing period with no significant change occurring although a trend towards a slight reduction in advancing angle can be seen graphically in both of these cases the change over time is not statistically significant p ns treatment results in a statistically significant reduction in advancing angle p lt 0 001 after all wearing periods the advancing angle indicates the wettability of the lens in the non wetted state this is the case when the surface film is absent upon initial lens insertion or when the lens becomes dewetted during wear which is when the lens is most problematic to the patient the poloxamine treated lenses remain more wettable when dry than untreated lenses at all times over the 8 hours of wear and this is likely to be the result of a layer of adherent poloxamine comfort agent untreated lenses are not significantly modified by the tear film over this time period fig2 shows the receding angles for fresh contact lenses from a poloxamine containing packing solution compared to fresh contact lenses from a conventional saline packing solution over a period of 8 hours the data is shown in table 2 below in the case of the receding angles no significant differences were found between treated and untreated lenses p ns results show that.