expression of cd36 140 was observed this result suggests that the cb composition may regulate lipid absorption and transfer ppar u03b3 is expressed in high levels in adipose tissue and plays a role in increasing insulin sensitivity as well as in promoting fatty acid uptake into adipocytes and adipocyte differentiation the net effect of these processes is to increase triglyceride storage in adipocytes reducing delivery of fatty acids to the liver as shown in fig4 the cb administered rats exhibit an increased ppar u03b3 expression in adipose and liver tissue of the cb treated rats the cb administered rats also exhibit and increased mrna expression of ppar u03b3 170 in the small intestine tissue the data suggests that the cb composition enhances ppar u03b3 expression which improve insulin sensitivity thereby regulating lipid metabolism in these tissues now referring to fig5 sterol regulatory element binding protein srebp 1c is a master regulator of lipogenic gene expression in adipose and liver tissue the expressions of adipogenesis related genes including srebp1c may decrease in the adipose of animal tissue exposed to a long term high fat diet as shown in fig5 the cb administered rats exhibit enhanced mrna expression of srebp1c 35 in the adipose tissue compared with the control group the cb administered rats also exhibit enhanced mrna expression of sterol regulatory element binding transcription factor 1 srebf1 47 which may play an important role in regulation of adipose fat deposition moreover the cb administered rats exhibit increased adipose 51 and hepatic 72 glycogen synthase continuing to refer to fig5 srebp1c also has a.