example in the illustrated embodiment the isolation surface 720 include a reflective foil 722 thereon which is configured to prevent light from illumination sources 710 from directly entering the imaging passage 704 without first engaging a substrate under examination alternate isolation materials may be used on the isolation surface 722 including without limitation dyes foils impregnations etc optionally the cap device 714 may be disposable and may be configured to detachably couple to the body 702 fig2 shows yet another embodiment of a reflectance avoidance imaging system as shown the reflectance avoidance imaging system 810 includes an imaging device 812 having a spacer or tissue engaging tip 814 attached thereto the imaging device 812 includes a body 816 having a distal portion 818 configured to receive and engage the spacer 814 in one embodiment the spacer 814 is detachably coupled to the body 816 optionally the spacer 814 may be non detachably coupled to the body 816 referring again to fig2 the imaging body 816 includes one or more conduits formed therein in the illustrated embodiment the body 816 includes an imaging conduit 820 configured to project light from a light source not shown to a work surface in addition the imaging conduit 820 collects light reflected from the work surface and transports the reflected light to a sensor suite not shown in communication therewith exemplary sensor suites include without limitation a ccd or any other type of imaging or sensing device spectral photometers and the like optionally a secondary imaging conduit 822 may be positioned within the body 816 for example the secondary imaging conduit 822 may be configured to measure co 2 within tissue through the use of a co 2 sensing dye the co 2 sensing dye enables the measurement of fluorescence decay and may.