temperature the blender is run for 30 minutes with intensification action to assure initial blending of the material 4 the lecithin methyl and propyl parabens tween 80 and povidone are dissolved in a volume of methylene chloride equal to approximately one fifth 1 5 the weight of bl s640 sesquihydrate required 5 using aseptic conditions the solution of step 4 is passed under positive pressure through a sterile 0 22 micron millipore filter into an appropriate sterile container located in a sterile area 6 using the 34 liquid addition apparatus 34 of the blender add the required volume of sterile pyrogen free methylene chloride solution of step 5 in five equal portions after each addition of solution the intensification bar is utilized for a maximum of 2 minutes using 4 34 agitation 34 periods during the 15 minutes blending period required for each addition of solution at the termination of each blending period the pressure developed during the blending process must be released noted on gauge on shell of blender and vacuum applied to remove the methylene chloride vapors this must be repeated to assure complete removal of vapors to aid in the evaporation and removal of vapors heat at 115 u00b0 f may be applied to the shell by circulating hot water through the walls 7 when all the solution has been added and blend properly vacated of vapors the material is dropped from the blender and trayed for drying the material is placed in covered trays and placed in a hot air atmospheric oven and dried for 6 hours the temperature of heated air should not exceed 130 u00b0 f after 6 hours of heating the heat is turned off and air circulated over.