acetone thereafter 1 4 g of maleic acid in 15 ml of acetone are added resulting in a while solid which is then crystallized from methanol 1 2 g are obtained of n cyano n 39 2 2 aminoiminomethyl amino 4 thiazolyl methyl thio ethyl formamidine maleate acid elemental analysis found c 39 12 h 4 61 n 23 89 calculated c 39 09 h 4 29 n 24 55 ir spectrum characteristic bands at 2190 cm 1 c tbd n st and 1615 cm 1 c u2550 n st to a solution of 2 48 g of 3 3 1 piperidinylmethyl phenoxy 1 propanamine prepared according to british pat no 2 023 123 which is hereby incorporated by reference in 25 ml of absolute ethanol are added dropwise 0 98 g of ethyl n cyano formimidate in 15 ml of ethanol under stirring and at room temperature stirring is maintained for 30 minutes and then the ethanol is removed by underpressure distillation an oil residue is formed which is then dissolved in 250 ml of ethyl ether after which 0 95 ml of 10n hcl ethanol are added yielding 1 4 g of n cyano n 39 3 3 1 piperidinylmethyl phenoxy propyl formamidine hydrochloride elemental analysis found c 59 03 h 7 78 n 14 89 calculated c 60 61 h 7 48 n 16 63 ir spectrum characteristic bands at 2190 cm 1 c tbd n st and 1620 cm 1 c u2550 n st the blocking activity of histamine h 2 receptors was tested in sprague dawley albino male rats weighing 350 450 g animals subject to 18 hour fasting were anaesthetized with urethane 1 5 g kg i p after which a longitudinal incision was performed on.