gram negative bacteria and are also effective in inhibiting the growth of mold and mildew inorganic particulate antimicrobial agents can also be used such as silver zeolites namely irgaguard b5000 which is a combination of zinc oxide and dht 4a 2 and agzn zeolite ii irgaguard b8000 which is agzn zeolite ii both of which are supplied by ciba specialty chemicals corporation of tarrytown n y as well as alphasan rc 5000 which is silver sodium hydrogen zirconium phosphate supplied by milliken chemicals of spartanburg s c in accordance with the invention any antimicrobial chemical may be used so long as it can be carried by a sizing mixture and can be incorporated within the interstices of the paper fibers following deposition of the sizing mixture along the paper web turning once again to the paper manufacturing process after passing the paper web through the sizing press the paper web now of course impregnated with the antimicrobial chemicals from the sizing mixture is passed over a heated drying drum that evaporates the remaining water the paper is then ready to be rolled up and delivered for production into paper sheets forms folders and the like as is well known in the art it will thus be seen that the objects set forth above among those made apparent from the preceding description are efficiently attained and since certain changes may be made in the processes and products described herein without departing from the spirit.