a suitable carrier adhesive as is known in the art fibrin glue also called fibrin sealant consists of two main components fibrinogen and thrombin these are typically for example loaded into two syringes with tips forming a common port when injected the two components meet in equal volumes at the point of delivery the thrombin converts the fibrinogen to fibrin by enzymatic action at a rate determined by the concentration of thrombin the more concentrated thrombin solution produces a fibrin clot in about 10 seconds and the more dilute thrombin solution forms the clot about 60 seconds after the glue is applied to the surgical field both the extrinsic and the intrinsic mechanisms of blood coagulation are bypassed but the physiological final common pathway of coagulation is faithfully replicated factor xiii present in the fibrinogen component of the glue cross links and stabilizes the clot 39 s fibrin monomers some preparations of fibrin glue contain aprotinin to delay the fibrinolytic action of plasmin fibrin glue bmj 9 apr 1994 308 933 fibrin glue is used as a tissue adhesive this glue can be used for repairing dura tears bronchial fistulas and for achieving hemostasis after spleen and liver trauma non limiting examples of such agents with or without a carrier that can be used in the compositions and methods of the present invention and introduced to the.