dosage of 10 u03bcg kg b w i p 1 hour before injury induction control 5 0 ml kg b w of saline i p the applied procedure usually produced a prominent swelling of the snout and was regularly fatal for controls but not for treated animals within nine postwounding days in contrast to controls only very modest posttraumatic swelling of the snout was observed subsequently the normal nasal respiration was only slightly impaired and survival undisturbed male albino rats of wistar strain 270 300 g b w were used in the experiments left tibias were fractured manually in the middle part of the bone under aether anaestesia no immobilization was used and animals were allowed to move freely in cages the animals were sacrified on the 5 th 8 th 12 th and 30 th day after the injury induction peptide seq id no 4 was given in a dosage of 10 0 u03bcg kg b w i p 1 hour before injury and subsequently once daily last application 24 h before sacrifice control group received simultaneously an equivolume of saline 0 9 5 0 ml kg b w i p a significantly improved healing rate was noted in all peptide treated animals at each of the investigated intervals all treated animals showed consistently lower local posttraumatic hematome than control animals and they restored their lesioned function quite sooner antiviral activity was investigated on new born mice balb c strain 24 hours old both sexes arbo viruses tbe tick borne encephalitis bhania dengue 1 2 3 4 sinbis west nile calovo hepatitis a lcm limphatic choriomeningitis and herpes type i were.