5 2 hz 5 42 1h d j 3 6 hz 4 46 4 42 1h m 4 00 3 90 2h m 3 71 3 68 2h m 3 58 3 48 1h m 3 38 3 28 1h m 3 21 3h s 3 19 3 15 1h m 2 82 3h d j 8 4 hz 2 33 2 27 1h m 2 18 2 14 1h m 1 93 1 88 1h m c 22 h 29 n 2 o 4 s requires 417 55 experimental for compounds synthesized for comparison of biological activity see reference compounds in table 1 to a solution of compound 6 0 29 g 1 42 mmol in tetrahydrofuran 3 5 ml was added triethylamine 0 20 ml 1 43 mmol at 0 u00b0 c and under argon ethylchloroformate 0 11 ml 1 15 mmol was added the reaction was stirred for 2 5 hours at 0 u00b0 c and then at room temperature for 1 hour compound 1 0 27 g 1 14 mmol was dissolved in tetrahydrofuran 1 5 ml and added to the reaction mixture the reaction was stirred at room temperature for 21 hours then poured into ethyl acetate 70 ml and washed with saturated sodium hydrogen carbonate solution 15 ml water 15 ml and brine 15 ml the organics were dried mgso 4 and concentrated in vacuo column chromatography dichloromethane methanol 9 1 followed by ethyl acetate 100 u2192 ethyl acetate methanol 9 1 gave the product as a yellow solid this was converted to the hcl salt by dissolving in dichloromethane 1 ml.