
{"publication_number": "US-7528128-B2", "abstract": "the present invention provides a compound of general formula 5 , useful as potential antitumour agents against human cancer cell lines . the present invention further provides a process for the preparation of pyrrolobenzodiazepine hybrids of general formula 5 wherein , x1 , x2 , x3 is selected from h or cl or ch3 , y is selected from o or nh , z is selected from c \u2550 o or ch2 and n = 1 to 4 .", "application_number": "US-89310107-A", "description": "accordingly , the present invention provides a process for preparation of pyrrolo [ 2 , 1 - c ][ 1 , 4 ] benzodiazepine hybrids of formula 5 of the drawing accompanying the specification where n = 1 - 5 , which comprises reacting { 2 -[( n - bromoalkyl )- 3 , 5 dichloro phenyl ]( phenyl ) methanone of formula 1 with 2s - n -( 4 - hydroxy - 5 - methoxy - 2 - nitrobenzoyl ) pyrrolidine - 2 - carboxaldehyde diethylthioacetal of formula 2 in presence of ch 3 coch 3 / k 2 co 3 for a period of 48 hr . with isolating ( 2s )- n -{ 3 -[ benzoyl ( 4 - chlorophenyloxy ) propyl ] oxy - 5 - methoxy - 2 - nitrobenzoyl 