a medicament for the treatment or prophylactic treatment of a glaucoma or elevated intraocular pressure b psychosis for example any conditions characterized by psychotic symptoms such as hallucinations paranoid or bizarre delusions or disorganized speech and thinking e g schizophrenia schizoaffective disorder schizophreniform disorder psychotic disorder delusional disorder and mania such as in acute manic episodes and bipolar disorder c traumatic brain injury the phrase u201c compounds of the invention u201d or u201c pde 1 inhibitors of the invention u201d encompasses any and all of the compounds disclosed herewith e g a compound of formula i or any of 1 1 1 127 formula ii a ii b or any of 2 1 2 24 and formula p a or p b or any of 3 1 3 132 in free or salt form the words u201c treatment u201d and u201c treating u201d are to be understood accordingly as embracing prophylaxis and treatment or amelioration of symptoms of disease as well as treatment of the cause of the disease for methods of treatment the word u201c effective amount u201d is intended to encompass a therapeutically effective amount to treat a specific disease or disorder the term u201c pulmonary hypertension u201d is intended to encompass pulmonary arterial hypertension the term u201c patient u201d include human or non human i e animal patient in particular embodiment the invention encompasses both human and nonhuman in another embodiment the invention encompasses nonhuman in other embodiment the term encompasses human the term u201c comprising u201d as used in this.