ml of a 2 n aqueous hydrochloric acid solution for 2 h at 40 u00b0 c then the solvent is eliminated in vacuo and the residue is recrystallised from ethanol ms esi ms esi m h m h 155 212 157 143 171 141 184 198 170 251 210 194 253 196 224 171 183 1 g 3 15 mmol 2 4 carboxy phenylamino 4 chloro 5 trifluoromethyl pyrimidine are dissolved in 5 ml dmf and combined batchwise with 3 36 g 18 89 mmol n bromosuccinimide the reaction mixture is stirred for 16 h at ambient temperature the solvent is eliminated in vacuo and the residue is purified by column chromatography the carrier used is c18 rp silica gel and a gradient is ran through which consists of 95 water and 5 acetonitrile at the starting point and consists of 2 water and 98 acetonitrile at the finishing point 0 1 formic acid is added in each case to both the water and to the acetonitrile 500 mg 3 102 mmol 5 amino 3h quinazolin 4 one are combined with 2 ml 15 596 mmol 1 bromo 2 fluoroethane 125 mg 3 125 mmol sodium hydride are added thereto and the mixture is stirred for 5 days at ambient temperature the reaction mixture is diluted with 100 ml of ethyl acetate and washed with 100 ml saturated aqueous sodium chloride solution the aqueous phase is combined with.