were prepared with a binding solution comprised of an aqueous solution of hydroxypropylcellulose granulation was performed with a high shear granulator the resultant wet mass was fluid bed dried milled blended with extragranular excipients to aid disintegration flow and compressibility and subsequently tabletted on a tablet press these core tablets were film coated to standardize appearance and to improve compliance i e ease of swallowing excipients included but were not limited to croscarmellose sodium magnesium stearate hydroxypropylcelluse hydroxypropylmethylcellulose lactose glyceryl behenate polyvinylpyrrolidine mannitol titanium dioxide and microcrystalline cellulose in general the dry granulation formulation was formed by dry blending in a tumble blender or high shear mixer a portion of the binding disintegration and lubrication powders this dry powder blend was formed into granules through the use of a roller compactor equipped with an oscillating shear granulator the ss mesh screen gap width gap force roller speed and granulator speeds were defined to optimize the formulation physical parameters as apparent to those skilled in the art of pharmaceutical processing excipients included but were not limited to croscarmellose sodium magnesium stearate hydroxypropylcelluse hydroxypropylmethylcellulose lactose glyceryl behenate polyvinylpyrrolidine mannitol titanium dioxide and microcrystalline cellulose table 3 4 1 proposed initial formulation compositions for dry granulation.