the gout risk particularly heavy drinkers including long time drinkers and drinkers having an alcohol intake over 45 g day are significantly related with the gout occurrence furthermore table 4 also shows significant interactions between the rs231247 g allele of alpk1 and the increasing risk of gout odds ratio 1 36 and 95 ci 1 14 to 1 64 and between the rs3825016 c allele of urat1 and that of gout odds ratio 1 56 and 95 ci 1 21 to 2 01 please refer to table 5 which shows the independent and the synergistic interaction between the snps of alpk1 and urat1 genes proposed in the present invention and the confounding factor of the alcohol consumption evidence of a gene environment interaction was found between the genotypes of the snp rs231247 of alpk1 or the snp rs3825016 of urat1 and the alcohol consumption the observed joint risk for heavy alcoholics over 45 g day of drinking who carried the at risk g allele of rs231247 of alpk1 odds ratio 5 03 and 95 ci 3 70 to 6 82 or the at risk c allele of rs3825016 of urat1 odds ratio 8 53 and 95 ci 5 22 to 13.