well as wounds in general where an infection can develop the dressing can incorporate the appropriate enzymes that would degrade initial biofilm formation on these dressings such systems are closed systems or mostly so and consequently the enzymes may or may not have moieties attached to them as a means of retaining them to the would dressing further an adjunct to the embodiment for this application there may also be associated with it suitable antimicrobial antibiotic agents endocarditis p aeruginosa has been shown to have a high affinity to cardiac tissue including heart valve tissue alginate biofilms of p aeruginosa at the root of p aeruginosa initial colonization as well as its proliferative growth rate is the production of a mucoid exopolysaccharide layer comprised of alginate this exopolysaccharide layer along with lipopolysaccharide protects the organism from direct antibody and complement mediated bactericidal mechanisms and from opsonophagocytosis this protective biofilm allows p aeruginosa to expand grow and to exist in harsh environments that may exist outside the alginate biofilm it is not surprising that the alginate biofilm is considered as an important virulence factor the alginate biofilm or u201c slime matrix u201d consists of a secreted exopolysaccharide that serves as the backbone structure of the biofilm alginate is a polysaccharide copolymer.