genes or sirna are prepared and used for increased delivery to the pathologic site for instance by targeting using specially modified liposomes with tumour specific peptides the sequence of each hybrid adenoviral sfv construct is shown at the end of the present description the present invention will now be further described with reference to the following examples and drawings which are present for the purposes of illustration only and are not to be construed as being limiting on the invention fig1 shows the essential elements of the hybrid adenoviral sfv vector fig3 shows a schematic diagram of hybrid shuttle plasmid at the end of the present description is showed a sequence of hybrid ad sfv vector containing e1 e2 and e3 deletions from the adenovirus backbone the examples describe the use of a hybrid adenoviral sfv vector for delivery of rna interference constructs against the following targets 1 cyclin family of proteins e g cyclin a b c d and e these are proteins that regulate the cell cycle disruption of these functions prevents cell division 2 essential metabolic enzymes e g atpases or enzymes involved in glycolysis and the mitochondrial membrane electron transport chain these enzymes regulate the essential energy metabolism of the cell disruption of these functions disrupts cell viability 3 p53 mutants specifically.