ingredients for example combination therapies though not illustrated there could be membranes between the components e g lipid soluble membranes between water soluble formulations and or an end piece fig1 13 and 14 illustrate injectates with different solid formulations in fig1 the solid formulation takes the form of beads 46 in fig1 and 14 they are granules particles or crystals 48 in fig1 a barrier 50 is shown between the formulation 42 and the pioneer projectile 10 the skilled man will of course realise that the features illustrated with reference to one embodiment could easily be applied to other embodiments an injectate will be introduced into a human or animal using a device that injects the injectate in a needleless manner one such device is illustrated by way of example only in fig1 the needleless injection device 60 is shown in the primed position it comprises an outer housing or holder 62 the lowermost end 64 of which is slidably mounted over the uppermost end 66 of an innermost casing 68 at the lowermost end 70 of innermost casing 68 is fitted a disposable component 72 such as for example a drug cassette the disposable component comprises a casing 74 having a central aperture or chamber 76 in which is mounted the injectate.