reduced to the corresponding amine which may then be acylated to form the desired reverse amide compounds i wherein r 4 is a urea group u2014 nhc u2550 o nhr 6 or thiourea group u2014 nhc u2550 s nhr 6 may also be prepared from the isocyanate v or the corresponding isothiocyanate by reaction with the appropriate amine h 2 nr 6 compounds i wherein r 4 is a carbamate group u2014 nr 7 c u2550 o or 6 may be prepared by the reaction of the isocyanate with an appropriate alcohol r 6 oh further details of the synthetic methods for the preparation of compounds i of the invention and intermediates such as iii may be found in the examples herein y is u2014 ch 2 u2014 u2014 ch 2 ch 2 u2014 or u2014 ch 2 ch 2 ch 2 so that the ring of which y is a part is a benz fused 5 6 or 7 membered ring currently it is preferred that y be u2014 ch 2 ch 2 u2014 the radical r 4 x u2014 is preferably in the 4 position of the phenyl ring x may be for example a bond or a u2014 ch 2 u2014 or u2014 ch 2 ch 2 39 radical a bond is presently preferred r 3 may be for example h f cl methyl methoxy or methylenedioxy currently it is preferred that r 3 is h r 1 may be for example h f cl methyl methoxy currently it is preferred that r 1 be hydrogen or fluoro r 4 represents a carboxylic acid group u2014 cooh or an ester thereof or u2014 c u2550 o nr 6 r 7 u2014 nr 7 c u2550 o.