a cholesterol biosynthesis inhibitor pharmaceutical composition and a substituted azetidinone absorption inhibitor pharmaceutical composition the kit will preferably include directions for the administration of the separate components the kit form is particularly advantageous when the separate components must be administered in different dosage forms e g oral and parenteral or are administered at different dosage intervals following are examples of preparing 3 unsubstituted azetidinones starting materials and compounds of formula i the stereochemistry listed is relative stereochemistry unless otherwise noted the terms cis and trans refer to the relative orientations at the u03b2 lactam 3 and 4 positions preparation 1 str18 step 1 preparation of trans 2 phenyl cyclohexylbromoacetate dissolve trans 2 phenyl cyclohexanol 0 0113 mole in anhydrous thf cool to 15 u00b0 c add nah 1 2 eq in portions and stir for 30 min add bromoacetyl chloride 1 5 eq dropwise and stir overnight at room temperature cool the reaction mixture to 0 u00b0 c and quench with t butanol 5 ml and water dropwise 10 ml warm the mixture to room temperature dilute with ethyl acetate etoac and wash in sequence with water 2 u00d7 50 ml and brine 2 u00d7 50 ml dry the organic layer over mgso 4 filter and concentrate purify the resultant residue by flash silica gel chromatography eluting with hexane u2192.