and 25 microliters 0 26 mmole of acetic anhydride dissolved in 0 5 ml of methylene chloride and the mixture sonicated on low power following the protocol 20 seconds 34 on 34 and 40 seconds 34 off 34 over a period of 2 hours the reaction vessel is then transferred to the magnetic separation region and the soluble components of the reaction mixture removed by aspiration using one of the liquid robotic arms to the reaction vessel is then added 2 ml of methylene chloride and the mixture is sonicated on low power for 20 seconds the reaction vessel is then moved to the magnetic separation region and the solvent is removed by aspiration this process is then repeated two more times and then the paramagnetic beads are washed with 2 ml of methanol using the same protocol a total of two times finally the paramagnetic beads bearing the reaction product are washed with methylene chloride a total of three times in that order b synthesis of gly ala bound to rink amide linker in this example a n fmoc substituted amino acids are abbreviated fmoc xxx where xxx is the conventional three letter abbreviation for any of the amino acids to the fmoc protected magnetic particles.