cells infection with hcmv davis or hcmv ad169 m o i 0 03 are detached 3 hours after the infection and added dropwise in 20 u03bcl of mem 10 fcs v v 1 glutamine v v 1 pen strep v v to a moist sponge the sponges are incubated for 3 4 hours to allow the cells to adhere then following the addition of medium mem 10 fcs v v 1 glutamine v v 1 pen strep v v the sponges are incubated overnight for the transplantation the immunodeficient mice are anaesthetized with avertin or a ketamine xylazine azepromazine mixture the fur on the back is removed using a shaver the epidermis is opened 1 2 cm unstressed and the moist sponges are transplanted under the dorsal skin the surgical wound is closed with tissue glue or clips 4 6 hours after the transplantation the mice can be treated for the first time one treatment is given on the day of the operation on the subsequent days oral treatment with substance is carried out three times a day 7 00 h and 14 00 h and 19 00 h twice a day 8 h and 18 h or once a day 9 h over a period of 8 days the daily dose is for example 1 or 3 or 10 or 30 or 100 mg kg of body weight the volume administered is 10 ml kg of body weight the substances are formulated in the form of a 0 5 tylose suspension.