over a 4 hour period with an equimolar quantity of trifluoroacetic anhydride 3 in benzene under an inert atmosphere at 2 u00b0 3 u00b0 c the reaction mixture was diluted with water the organic phase washed with aqueous sodium bicarbonate and water and the trifluoroacetylpyrrole 4 isolated in over 75 yield by evaporation of the solvent m p 45 u00b0 46 u00b0 c mass spectrum m z 163 m trifluoroacetylpyrrole 4 in methanol was reacted with solid sodium borohydride in portions at 0 u00b0 5 u00b0 c the reaction mixture was treated with a saturated solution of sodium bicarbonate and the product 2 2 hydroxy 1 1 1 trifluoroethyl pyrrole 5 was extracted into ether the ether solution was washed with aqueous sodium bicarbonate water dried and the product isolated in over 90 yield by evaporation of the solvent mass spectrum m z 165 m equimolar quantities of pyrrole 2 and 2 2 hydroxy 1 1 1 trifluoroethyl pyrrole 5 5mmol each in tetrahydrofuran 30 ml were refluxed with catalytic amounts of hydrochloric acid for 2 h under an inert atmosphere gc analysis of the reaction mixture indicated the presence of the desired dipyrromethane bis pyrrol 2 yl trifluoro methylmethane 6 in up to 65 yield the pure product was isolated by neutralization of the.