thionylchloride may also be used for this conversion reaction temperatures can range from 0 to 100 u00b0 c for times of 1 hour to 7 days compound 3 can be treated with hydrazinecarbodithionic acid methylester 4 audrieth l f scott e s kippur p s j org chem 1954 19 733 in ether solvents at temperatures of 0 u00b0 c to 100 u00b0 c for 1 hour to 7 days to give compound 5 treatment of 5 with acids such as hydrochloric acid methanesulfonic acid or p toluenesulfonic acid in aromatic or ether solvents at 0 u00b0 c to 100 u00b0 c will give compound 6 compound 7 can be prepared from 6 using sodium thiomethoxide in dmf at 0 u00b0 c to 100 u00b0 c for 1 hour to 7 days compound 3 can also be treated with thiosemicarbazide in pyridine or ether solvents to give 9 treatment of 9 with acids such as hydrochloric acid methanesulfonic acid or toluenesulfonic acids gives compound 10 str11 in step 1 of scheme iv those compounds of formula i where y does not contain sulfur are treated with an equivalent amount of m chloroperbenzoic acid in methylene chloride to provide compounds of formula ii other suitable oxidizing agents are kmno 4 naio 4 and hydrogen peroxide in step 2 the use of two or more equivalents of oxidizing agent again preferably m chloroperbenzoic acid converts compounds of formula i to compounds of formula ij in step 1 of scheme v compounds of formula id or ih are treated with iodomethane in the presence of a base such as potassium hydride potassium t butoxide or preferably sodium hydroxide in a solvent such as dimethylformamide.