the invention can be detected for example by a binding assay the term u201c binding reagent u201d and like terms refers to any compound composition or molecule capable of specifically or substantially specifically that is with limited cross reactivity binding another compound or molecule which in the case of immune recognition is an epitope the binding reagents typically are antibodies preferably monoclonal antibodies or derivatives or analogs thereof but also include without limitation f v fragments single chain f v scf v fragments fab u2032 fragments f ab u2032 2 fragments humanized antibodies and antibody fragments camelized antibodies and antibody fragments and multivalent versions of the foregoing multivalent binding reagents also may be used as appropriate including without limitation mono specific or bi specific antibodies such as disulfide stabilized f v fragments scf v tandems scf v 2 fragments dibodies tribodies or tetrabodies which typically are covalently linked or otherwise stabilized i e leucine zipper or helix stabilized scf v fragments u201c binding reagents u201d also include aptamers as are described in the art methods of making antigen specific binding reagents including antibodies and their derivatives and analogs and aptamers are well known in the art polyclonal antibodies can be generated by immunization of an animal monoclonal antibodies can be prepared.