were 5 g hr m 2 or less which were within the normal range from day 15 after the start of feeding or later tewl showed an increasing tendency particularly increased over time in the control feed administration group reaching a rate as high as 25 97 u00b1 3 85 g hr m 2 at the time of completing the feeding period day 43 tewl also increased in the collagen administration group but was as slightly low as 23 72 u00b1 9 38 g hr m 2 at the time of completing the feeding period although there was no significant difference fig6 shows the changes in body weight in each group the data taken before the start of feeding day 0 on day 15 and day 29 and after completing the feeding period day 43 are shown as the average value u00b1 standard error 7 mice per group the body weights at the time of starting feeding were 18 7 to 20 8 g then the body weights increased over time in both groups with no difference in the increase rate between the groups fig7 shows the macroscopic findings in each group these macrophotogrpahs were taken before collecting samples for 7 histological examination from the mice of each group after the completion of the feeding period b collagen d control feed when the macroscopic findings of the mouse head dorsal part and face of each group at the time of test completion were compared the control feed administration group was found to have progressed dermatitis at each site in the collagen administration group on the other.