curcumin 1 7 bis 4 hydroxy 3 methoxyphenyl 1 6 heptadiene 3 5 dione piperine 1 5 1 3 benzodioxol 5 yl 1 oxo 2 4 pentadienyl piperidine resiniferatoxin 6 7 deepoxy 6 7 didehydro 5 deoxy 21 dephenyl 2l phenylmethyl 20 4 hydroxy 3 thoxybenzeneacetate or pharmaceutically effective salts analogues derivatives or equivalents thereof the treatment agent 20 can include capsaicin another vanilloid compound rtx or combination thereof alone or in combination with other substances which will be generically called a vanilloid containing treatment agent 20 the vanilloid containing treatment agent can be applied through the port 22 or ports 22 to the mucosal lining or extrinsically to the outside of an organ the vanilloid containing treatment agent can also be injected into the targeted tissue region or organ wall the treatment agent 20 can be a solution a gel a powder a pellet or other form the treatment agent may be released immediately or be a sustained release product such as a slow released implant slow release gel coated pellet microsphere or other form the vanilloid containing treatment agent 20 may be applied or injected as primary therapy or as a neoadjuvant or adjuvant procedure for example rf energy may be used to incite a wound followed by application of the vanilloid containing treatment agent to facilitate exuberant wound healing in dyspepsia and.