upon the requirements of the patient the severity of the condition being treated and the compound being employed determination of the proper dosage for a particular situation is within the skill of the art generally treatment is initiated with smaller dosages which are less than the optimum dose of the compound thereafter the dosage is increased by small increments until the optimum effect under the circumstances is reached for convenience the total daily dosage may be divided and administered in portions during the day if desired the following nonlimiting examples illustrate the inventors 39 preferred methods for preparing the compounds of the invention 3 4 5 trimethoxybenzoyl chloride 2 03 g 8 8 mmol in dichloromethane 10 ml is added dropwise to a solution of 2 chloro 3 methylphenyl piperazine 1 98 g 8 0 mmol and triethylamine 4 5 ml 32 0 mmol in dichloromethane 90 ml and stirred for 2 hours at room temperature the reaction mixture is washed with water dried magnesium sulfate and concentrated in vacuo the resulting solid is purified by medium pressure liquid chromatography mplc on silica gel eluting with 40 ethyl acetate hexane to give 2 52 g of the title compound as a white solid mp 156 159 u00b0 c a solution of aluminum chloride 0 279 g 2 09 mmol in anhydrous diethyl ether 20 ml is added dropwise to a suspension of lithium aluminum hydride 0 238 g 6 27 mmol in anhydrous tetrahydrofuran 20 ml at 0 u00b0 c and stirred for 0 5 hour to this mixture is added dropwise a solution of 4 2 chloro 3 methylphenyl piperazine 1 yl 3 4 5 trimethoxyphenyl methanone 2 12 g 5 23 mmol in anhydrous tetrahydrofuran.