was cooled to room temperature and filtered the filter was concentrated under reduced pressure and 80 ml of water was added the mixture was extracted with dichloromethane and the organic layer was concentrated under vacuum at 60 u00b0 c to get 39 4 g of n 2 6 dimethylphenyl 1 piperazinylacetamide having a yield of 63 1 hnmr cdcl 3 2 23 u02dc 2 27 s 6h 2 67 s 4h 2 96 u02dc 2 98 t 4h 3 19 u02dc 3 21 s 2h 7 08 u02dc 7 26 m 3h 8 69 s 1h 26 g 0 65 mol of sodium hydroxide 150 ml of water 150 ml of ethanol 62 g 0 5 g of guaiacol were successively added into a reaction flask and 103 g 0 8 mol of 1 3 dichloro 2 propylalcohol was slowly dropwise added till completion the mixture was heated up to 45 u00b0 c for 24 h the reaction product was extracted three times with 150 ml of dichloromethane each and the organic layer was combined dried with anhydrous magnesium chloride and distilled under reduced pressure the fraction at 160 u00b0 c and a pressure of 2 kp was collected to get 73 6 g of faint yellow liquid.