hydrogen lower alkyl or acyl moiety and r5 is an acyl moiety u2014 ch 2 cooh or u2014 so 2 lower alkyl unsubstituted or mono bi or trisubstituted with halogen preferably r1 r2 r3 independently of each other is hydrogen halogen lower alkyl or alkoxy and x is u2014 nr4r5 preferably r1 r2 r3 independently of each other is hydrogen halogen lower alkyl or alkoxy and x is unsubstituted pyrollidine or pyrollidine substituted with acid preferably r4 is hydrogen lower alkyl or acyl moiety and r5 is an acyl moiety u2014 ch 2 cooh or u2014 so 2 lower alkyl unsubstituted or mono bi or trisubstituted with halogen preferably r4 is hydrogen and r5 is u2014 so 2 lower alkyl unsubstituted or mono bi or trisubstituted with halogen preferably x is pyrollidine substituted with carboxylic acid or acetic acid preferably r1 r2 r3 independently of each other is hydrogen fluoro chloro methyl or methoxy preferably r5 is u2014 ch 2 cooh or u2014 so 2 lower alkyl unsubstituted or mono bi or trisubstituted with halogen preferably r5 is u2014 so 2 ch 3 or u2014 so 2 cf 3 n 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenyl succinamic acid trans 2 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenylcarbamoyl cyclopentanecarboxylic acid 1r 2r 2 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenylcarbamoyl cyclopentanecarboxylic acid 1s 2s 2 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenylcarbamoyl cyclopentanecarboxylic acid 1r 2s 2 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenylcarbamoyl cyclopentanecarboxylic acid 1s 2r 2 3 2 u2032 4 u2032 difluoro biphenyl 4 yloxymethyl phenylcarbamoyl cyclopentanecarboxylic acid s 1 3 4 u2032 5 u2032 difluoro 2 u2032 methoxy biphenyl 4 yloxymethyl phenyl pyrrolidine 2 carboxylic acid s 1.