embodiments set forth herein rather these embodiments are provided so that this disclosure will be thorough and complete and will fully convey the scope of the invention to those skilled in the art the terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention as used in the description of the invention and the appended claims the singular forms u201c a u201d u201c an u201d and u201c the u201d are intended to include the plural forms as well unless the context clearly indicates otherwise unless otherwise defined all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs all publications patent applications patents and other references cited herein are incorporated by reference in their entireties for the teachings relevant to the sentence and or paragraph in which the reference is presented the term u201c nucleic acid u201d as used herein refers to any nucleic acid including both dna and rna nucleic acids of the present invention are typically polynucleic acids that is polymers of individual nucleotides that are covalently joined by 3 u2032 5 u2032 phosphodiester bonds the term u201c nucleotide u201d refers to a building block of dna and rna consisting of a nitrogenous base a five carbon sugar and a phosphate group.