c thioamido n amido c carboxy o carboxy sulfinyl sulfonyl sulfonamido trihalomethanesulfonamido trihalomethanesulfonyl silyl guanyl guanidino ureido phosphonyl amino and u2014 nr x r y with r x and r y as defined above an u201c alkenyl u201d group refers to an alkyl group as defined herein having at least two carbon atoms and at least one carbon carbon double bond an u201c alkynyl u201d group refers to an alkyl group as defined herein having at least two carbon atoms and at least one carbon carbon triple bond an u201c alkoxy u201d group refers to both an u2014 o alkyl and an u2014 o cycloalkyl group as defined herein an u201c aryloxy u201d group refers to both an u2014 o aryl and an u2014 o heteroaryl group as defined herein a u201c heteroaryloxy u201d group refers to a heteroaryl o u2014 group with heteroaryl as defined herein a u201c heteroalicycloxy u201d group refers to a heteroalicyclic o u2014 group with heteroalicyclic as defined herein a u201c thioalkoxy u201d group refers to both an s alkyl and an u2014 s cycloalkyl group as defined herein a u201c thioaryloxy u201d group refers to both an u2014 s aryl and an u2014 s heteroaryl group as defined herein a u201c thioheteroaryloxy u201d group refers to a heteroaryl s u2014 group with heteroaryl as defined herein a u201c thioheteroalicycloxy u201d group refers to a heteroalicyclic s u2014 group with heteroalicyclic as defined herein a u201c carbonyl u201d group refers to a u2014 c u2550 o u2014 r u2033.