suitable protecting group portion a r a suitable linking group portion and a q suitable reaction group portion c reacting a compound of formula a5 with a compound of formula a4 to prepare a compound of formula a6 wherein the formula i compound r 3 group incorporates certain portions of the r a linking group as a product of the reaction more specifically the procedure for the generation of mixed anhydride compounds of formula a3 includes to a nitrogen purged flask was added thf carboxylic acid and et 3 n the mixture was cooled to 0 u00b0 c and pivaloyl chloride in thf was added dropwise after addition the mixture was stirred at 0 u00b0 c for 1 hr then filtered and the precipitate was washed with thf the filtrate was concentrated and the product was used quickly without any purification in general the process for preparing a compound of formula i comprises the steps of more specifically the procedure for the generation of mixed anhydride compounds of formula a3 includes the steps more specifically the procedure for the generation of prodrug compounds of formula i includes the steps to a nitrogen purged flask was added 4 5 amino 1 2 6 difluorobenzoyl 1h 1 2 4 triazol 3 ylamino benzenesulfonamide prepared as described in wo2002057240 and thf the mixture was cooled to 0 u00b0 c and potassium tert butoxide was added dropwise after addition the mixture was stirred at 0 u00b0 c for 1 hr then a mixed anhydride in thf was added dropwise the stirring was continued for 30 min then the mixture was warmed to.