use returned to treatment 2 months later __________________________________________________________________________ mj marijuana etoh ethanol eighty eight per cent of the subjects ceased all cocaine use during the first treatment week and the remainder in the second week of flupenthixol decanoate treatment responding subjects uniformly described an amelioration of dysphoric symptoms including anhedonia seventy seven per cent of the subjects described a clear increase in energy by the third day after injection seventy seven per cent of the subjects also reported substantial decreases in the magnitude of craving induced by environmental cues contrasted to prior maximum stays in treatment the duration of retention in treatment was increased 260 means sem 8 7 2 7 v 23 0 6 9 t 2 61 paired p 0 028 compared to prior medication regimens employed with these subjects using heterocyclic antidepressants both compliance to psychotherapeutic treatment and retention were markedly improved the one non responding subject dropped out almost immediately after 10 mg flupenthixol administration he was subsequently readmitted after a full relapse lasting over 2 months both he and other subjects treated informally before this study at higher doses described more neuroleptic like effects than the responding subjects including anhedonia increased rather than decreased craving for cocaine and often diminished intensity or duration of cocaine 39 s euphoric effects but not complete blockade when cocaine smoking was resumed these flupenthixol effects directly produced substantial subjective distress refusal of further flupenthixol administration rather than subject use of the blocking effects.