6 alkoxycarbonyl aroyl c 1 3 acyl oxo pyridinyl c 1 3 alkyl imidazolyl c 1 3 alkyl tetrahydrofuranyl c 1 3 alkyl nitrile c 1 3 alkyl nitrile phenyl wherein the phenyl ring is optionally substituted with one to two halogen c 6 alkoxy di c 1 3 alkyl amino c 1 6 alkyl s o m or phenyl s o m wherein the phenyl ring is optionally substituted with one to two halogen c 1 6 alkoxy or di c 1 3 alkyl amino or z is optionally substituted with one to three one to three amino or amino c 1 3 alkyl wherein the n atom is optionally independently di substituted by aminoc 1 6 alkyl c 1 3 alkyl arylc 0 3 alkyl c 1 5 alkoxyc 1 3 alkyl c 1 5 alkoxy aroyl c 1 3 acyl c 1 3 alkyl s o m u2014 or arylc 0 3 alkyl s o m u2014 each of the aforementioned alkyl and aryl attached to the amino group is optionally substituted with one to two halogen c 1 6 alkyl or c 1 6 alkoxy or z is optionally substituted with one to three aryl or heterocycle as hereinabove described in this paragraph each in turn is optionally substituted by halogen c 1 6 alkyl or c 1 6 alkoxy or z is amino wherein the n atom is optionally independently mono or di substituted by c 1 6 alkyl or c 1 3 alkoxyc 1 3 alkyl c 1 6 alkyl branched or unbranched c 1 6 alkoxy.