is itself relatively short and amounts depending upon the volume to be administered to about 0 5 3 minutes with an injection rate of about 5 10 ml min being especially advantageous 34 multiple bolus administration 34 refers e g to the cumulated administration of two or more individual bolus injections which are administered over an interval of time i e one day two or more preferably three bolus injections are carried out daily whereby the therapy can extend over the course of several successive days this treatment scheme can be interrupted by one or two days so that administration in the form of bolus injections can take place for example on every second day during the whole treatment period essentially this cumulated administration of single boli differs from the known single bolus administration in that the administration is repeated daily several times if the time interval between the first and a subsequently following bolus injection is relatively short about 10 minutes up to one hour one speaks of a double bolus or multiple bolus administration if the time intervals are of the order of magnitude of several hours then one can also speak of a cumulated administration of single boli for the production of the pharmaceutical forms of administration with regard to the thrombolytically active protein the usual pharmaceutical adjuvants and additive.