ch 2 oh compounds can be alkylated to form the corresponding alkoxymethyl compounds e g using dimethylsulfate to form the methoxymethyl compound for compounds in which a and a 39 form a cycloalkyl group similar procedures can be used starting with str20 a known compound for example co 2 r can be converted to ch 2 oh by reduction procedures using a variety of metal or alkylaluminum hydrides and thereafter the ethers formed by standard procedures in all cases the amino group of formula iii compounds is preferably protected in the intermediates using the usual reagents and the protecting groups removed before condensation with formula ii compounds with regard to the removal of protecting groups from compounds of formula iv and n protected precursors of formula iii a number of deprotecting techniques are known in the art and can be utilized to advantage depending on the nature of the protecting groups among such techniques is catalytic hydrogenation utilizing palladium on carbon or transfer hydrogenation with 1 4 cyclohexadiene generally the reaction is carried at room temperature but may be conducted from 5 u00b0 to 65 u00b0 c usually the reaction is carried out in the presence of a suitable solvent which may include but are not limited to water methanol ethanol dioxane tetrahydrofuran acetic acid t butyl alcohol isopropanol or mixtures thereof the reaction is usually run at a positive hydrogen pressure.