protein or fragment thereof or rna molecule of a virus which is capable of interfering with rna silencing in an animal cell to suppress the silencing response of a host and or to reverse the silencing of the expression of a nucleotide sequence in an animal cell once established thus a rna silencing suppressor of the present invention can be used for the improvement of packaging producer cell lines for the production of recombinant virus particles or viral vectors including retro lenti baculo adeno adeno associated aav or hybrid virus particles such as adeno aav viruses this invention deals preferably with the production of recombinant virus particles which harbor a nucleotide construct which is able to produce a single transcript or multiple transcripts capable of folding into double stranded rna in a preferred embodiment of the invention the protein or rna molecule of the invention can be used for the improvement of packaging cell lines for the production of rna vectors such as retro or lentiviral vectors harboring a nucleotide construct which is able to produce a single transcript or multiple transcripts capable of folding into double stranded rna the invention further provides a nucleic acid construct comprising a nucleotide sequence encoding a protein or fragment thereof or rna molecule of a virus which is capable of interfering with rna silencing under the control of a suitable promoter for expression in a eukaryotic cell.