are activated they provoke the extension of the mixture and create a fluidic path as shown in fig1 c fig2 a to c show a similar embodiment to that show in fig2 where cavities and channels are combined 1 basis wafer 2 expandable element 3 left active portion 4 right active portion 5 middle passive portion 6 left passive portion 7 right passive portion 8 surface 9 channel 10 left heating element 11 right heating element 12 left flange 13 right flange 14 cavity 15 annular flange 16 annular heating element 17 18 19 20 cover wafer 21 anti adhesion layer 22 middle heating element 23 central upper passage 24 inlet valve 25 outlet valve 26 single open channel 27 preformed cavity 28 aspiration cavity 29 drug reservoir 30 lateral suction and dispensing unit 31 flower structure 32 pcb expancel pdms bi layer 33 non bonded region in a first embodiment the mixture layer is sandwiched between a basis wafer 1 and a cover wafer 1 20 an anti adhesion layer 21 is deposited on top of the mixture in contact with the upper plate as shown in fig6 a by using heating elements 10 11 placed onto the bottom plate the mixture is locally grown to create a cavity 14 fig6 b this cavity is then closed by again locally heating 22 the mixture fig6 c in front of the cavity by repeating this process the valve can be opened and closed several times fig6 d until the material.