from hydrogen halogen cf 3 c 1 6 alkyl c 1 6 alkoxy c 1 6 alkylthio c 1 7 acyl c 1 7 acylamino c 1 6 alkylsulphonylamino n n c 1 4 alkylamino c 1 6 alkylsulphinyl hydroxy nitro or amino aminocarbonyl aminosulphonyl aminosulphonylamino or n c 1 4 alkylamino optionally n substituted by one or two groups selected from c 1 6 alkyl c 3 8 cycloalkyl c 3 8 cycloalkyl c 1 4 alkyl phenyl or phenyl c 1 4 alkyl groups or optionally n disubstituted by c 4 5 polymethylene z is a group of formula or str2 wherein n is 2 or 3 p is 1 or 2 q is 1 to 3 r is 1 to 3 and r 5 or r 6 is c 1 7 alkyl c 3 8 cycloalkyl c 3 8 cycloalkyl c 1 2 alkyl or c 2 7 alkenyl c 1 4 alkyl having 5 ht m receptor antagonist activity application_number US 38928689 A description to 2 3 dihydroindole 5 g in dry dichloromethane 140 ml and triethylamine 5 85 ml at 0 u00b0 was added dropwise trichloromethyl chloroformate 5 ml in dry dichloromethane 20 ml the reaction mixture was stirred at room temperature for 2h then washed with water 5 ml and 5n hydrochloric acid solution 5 ml the organic phase was dried na 2 so 4 the solvent evaporated in vacuo and tne residue purified by filtration through a short alumina column eluting with dichloromethane to give the title compound.