molar equivalents of the bromide suitable solvents include hexanes heptanes tetrahydrofuran 1 2 dimethoxyethane and ether for example the aforesaid reaction is typically run for a period of time from 0 5 hours to 48 hours generally 1 hour at a temperature from u2212 78 to 40 u00b0 c generally from u2212 78 to 0 u00b0 c the aforesaid reaction is typically run for a period of time from minutes to several hours to 48 hours generally 1 hour where r 1 and r 2 are hetero hydrocarbyl groups and r 1 is not r 2 r 3 is h or an acetylene protecting group and y is 1 or 2 if present the protecting group r 3 of the compounds of formula iv is then removed by means known in the art in embodiments where r 3 is ch 3 3 u2014 si u2014 the product may be desilylated by contacting with a suitable desilylating agent such desilylating reagents include catalytic amounts 5 to 10 mol mol of fluoride compounds or dilute base such as sodium hydroxide potassium hydroxide potassium carbonate in an alcoholic solvent or an alcoholic solvent with a solubilizing co solvent such as tetrahydrofuran or diethyl ether or other desilylating reagents described in greene and wuts u201c protecting groups in organic synthesis u201d john wiley amp son press 2nd ed may be employed suitable solvents include ether tetrahydrofuran dichloromethane ethanol methanol and toluene for example the aforesaid reaction is run for a period of time from 0 5 hours to 5 hours generally 1 hour at a temperature from 0 to 40 u00b0 c generally from 10 to 25 u00b0 c all parts percentages ratios etc in the examples are by weight unless noted otherwise solvents and other reagents used were obtained from.