US 9091656 B2 abstract solid type sers active substrates are contained within optically transparent modules the modules allow for the controlled introduction of analyte bearing fluid into sers active substrates the modules also allow for the monitoring of sers signals emanating from analyte which have accumulated on the confined sers active substrates these sers signals may be monitored over time by direct readout of the sers substrates through the optically transparent module for chemical analysis and chemical detection applications application_number US 201013501716 A description while preferable embodiments of the invention have been shown and described herein it will be obvious to those skilled in the art that such embodiments are provided by way of example only numerous variations changes and substitutions will now occur to those skilled in the art without departing from the invention it should be understood that various alternatives to the embodiments of the invention described herein may be employed in practicing the invention the foregoing features and other aspects of the invention are explained in the following description taken in conjunction with the accompanying figures wherein in one embodiment a module of a system described herein comprises of a transparent tube or capillary containing sers active nanostructure s the sers active nanostructure s include silver or gold nano micro sized powders granules silver or gold nanoparticles coated micro nano sized inorganic particles powders granules and any other suitable substrates that are sers active and are able to be packed inside.