domains into a suitable configuration or to introduce codons create cysteine residues modify add or delete amino acids etc non limiting examples of antigen binding fragments include i fab fragments ii f ab u2032 2 fragments iii fd fragments iv fv fragments v single chain fv scfv molecules vi dab fragments and vii minimal recognition units consisting of the amino acid residues that mimic the hypervariable region of an antibody e g an isolated complementarity determining region cdr other engineered molecules such as diabodies triabodies tetrabodies and minibodies are also encompassed within the expression u201c antigen binding fragment u201d as used herein an antigen binding fragment of an antibody will typically comprise at least one variable domain the variable domain may be of any size or amino acid composition and will generally comprise at least one cdr which is adjacent to or in frame with one or more framework sequences in antigen binding fragments having a v h domain associated with a v l domain the v h and v l domains may be situated relative to one another in any suitable arrangement for example the variable region may be dimeric and contain v h v h v h v l or v l v l dimers alternatively the antigen binding fragment of an antibody may contain a monomeric v h or v l domain in certain embodiments an antigen binding fragment of an antibody.