
{"publication_number": "US-5298517-A", "abstract": "this disclosure describes novel imidazole compounds having the formula : ## str1 ## wherein r 1 and r 6 are described in the specification which have activity as angiotensin ii antagonists .", "application_number": "US-13368693-A", "description": "the novel compounds of the present invention are prepared according to the following reaction schemes . referring to scheme i , the 2 - lower alkyl - 4 - chloro - 1 -[[ 2 &# 39 ;-( 1h - tetrazol - 5 - yl )[ 1 , 1 &# 39 ;- biphenyl ]- 4 - yl ] methyl ]- 1h - imidazole - 5 - methanol 1 as the potassium salt , where r 1 is hereinbefore defined , is reacted with trityl chloride 2 in the presence of triethylamine in methylene chloride at reflux to provided protected intermediate 3 . intermediate 3 is oxidized with manganese dioxide in 1 , 2 - dichloroethane to give aldehyde 4 , where r 1 is hereinbefore defined , using the conditions of ho - shen lin , ashraff a . rampersaud , karen zimmerman , mitchell i . steinberg , and donald b . boyd , j . med . chem . 35 , 2658 ( 1992 ). the aldehyde 4 is reacted with methylmagnesium bromide to give the desired secondary alcohol 6 . aldehyde 4 may also be reacted with the phosphorane to give olefin 5 . alcohol 6 is oxidized with manganese dioxide in 1 , 2 - dichloroethane to give ketone 7 . the ketone 7 is reacted with grignard reagents r 2 mgbr where r 2 is hereinbefore defined , except hydrogen , to give the desired alcohol 8 . the alcohol 8 is dehydrated with { bis [ \u03b1 , \u03b1 - bis ( trifluoromethyl ) benzenemethanolato ]- diphenylsulfur 