artifact to show up in the sectioned biopsy and subsequent diagnostic slides referring to fig6 and 7 an orientation cassette 60 is used to orient special tissues not shown that must be sectioned u201c on edge u201d reference numerals corresponding to those from the first embodiment but having prime marks in fig6 and 7 refer to corresponding elements of structure tissue such as skin gal bladder bladder etc needs to be oriented to allow the pathologist to view a full cross section of the biopsy these samples can be quite small and therefore need to be retained in a cassette with small holes like the biopsy cassette 10 the orientation biopsy cassette 60 allows the histotechnologist to place the tissue in the proper orientation for sectioning at the time of gross in this predetermined orientation will be maintained through the tissue processing and embedding procedures thus maintaining the proper orientation to the cutting plane without having to remove the tissue and reorient it for sectioning in a paraffin mold the tissue is placed between upright posts 62 molded into the bottom wall 64 of the cassette 60 these posts 62 have been arranged in configurations that take into account average thickness and lengths of the tissue to be used in the cassette 60 the posts 62 are further arranged so that they are not directly in line with one another with respect to directions either parallel to or perpendicular to the sectioning blade path since the posts have more plastic material in them than the sidewall ribs 66 they could cause dulling of a portion of the microtome blade at an undesirable rate after repeated use therefore the posts 62 are positioned to minimize the number of posts 62 cut in succession in.