reaction mixture prepared above the mixture was stirred at room temperature for 14 hours the reaction mixture was filtered and the filtrate was washed successively with 1n hydrochloric acid water and saturated aqueous sodium hydrogen carbonate the organic layer was dried over sodium sulfate and concentrated under reduced pressure the residue thus obtained was recrystallized to afford 9 5 g 16 3 mmol of 1 3 5 3 methoxy 4 ethoxycarbonyloxyphenyl 2 4 pentadienoyl aminopropyl 4 benzhydrylpiperazine spectrophotometric data of the product support the structural formula viii shown below str7 to a solution of 180 mg 1 mmol of caffeic acid 3 4 dihydroxysuccinic acid in 10 ml of dichloromethane cooled to 0 u00b0 c was added 303 mg 3 mmol of triethylamine followed by addition of 326 mg 3 mmol of ethylcarbonyl chloride the mixture was stirred at 0 u00b0 c for 3 hours separately to a 10 ml ethanol solution of 440 mg 1 mmol of 1 2 phthaloylaminoethyl 4 benzhydroxypiperidine was added 63 mg 1 mmol of 80 hydrazine hydrate and the mixture was heated under reflux for 2 hours the reaction solution was concentrated under reduced pressure and to the residue thus obtained was added 10 ml of dichloromethane followed by addition of the reaction solution prepared above the mixture was stirred at room temperature for 2 hours the reaction solution was filtered and.