as plunger 1 is advanced axially sealable outer component 5 is also advanced which forces the fluid drug component 11 out of cartridge 2 through dispensing location 13 which is shown for example in fig4 in the exemplary version a lyophilization stopper 7 may be used in conjunction with a crimped region 8 to prevent fluid from leaving cartridge 2 until desired when the user is ready to allow fluid to leave cartridge 2 stopper 7 may be pierced unplugged dislodged opened etc thereby allowing fluid to exit cartridge 2 it will be appreciated that in some versions stopper 7 and crimped region 8 need not be used at all stopper 7 also may function to keep air and or bacterial or dust contaminants out of second chamber 6 also in some exemplary versions device 10 may be filled by first adding the liquid medicant to the chamber closest to the dispensing port 13 this liquid medicant can be lyophilized or if the material in this chamber is spray dried can be added to the same chamber then once the lyophilization process is complete the liquid may be filled into the other chamber that is away from the dispensing port and the rubber stopper may be inserted for sealing additionally the inner component in fig1 comprising the outer sealing member 5 and a plug 4 could be added inside many different types of cartridges auto injectors pen injectors or other drug delivery devices and or syringes adding one or more of these components comprising.