cream product using a standard technique of adding the emulsifier to the non aqueous phase and then mixing with the aqueous phase we found that no emulsion formed however when we added the emulsifier to the mixture of the non aqueous and aqueous phases with cooling according to the method of the invention we found that a useful emulsion did form this emulsion formed even though the relative proportion of the non aqueous and aqueous phases according to the successful method of the invention was the same as when an emulsion did not form using the standard technique of adding a non aqueous phase containing an emulsifier to an aqueous phase the resulting tri luma u2122 cream contains fluocinolone acetonide hydroquinone and tretinoin in a hydrophilic cream base for topical application each gram of tri luma u2122 cream contains as active ingredients fluocinolone acetonide 0 01 0 1 mg hydroquinone 4 40 mg and tretinoin 0 05 0 5 mg and as inactive ingredients butylated hydroxytoluene cetyl alcohol citric acid glycerin glyceryl stearate magnesium aluminum silicate methyl gluceth 10 methylparaben peg 100 stearate propylparaben purified water sodium metabisulfite stearic acid and stearyl alcohol see table 1 fluocinolone acetonide is a synthetic fluorinated corticosteroid for topical dermatological use and is classified therapeutically as an anti inflammatory it is a white crystalline powder that is odorless and stable in light the chemical name for fluocinolone acetonide is 6 11 16 6 9 di fluoro 11 21 dihydroxy 16 17 1 methylethylidene bis oxy pregna 1.