quinazolyl isoquinolyl or phenyl w wherein w is hydrogen ortho alkyl ortho cycloalkyl ortho alcoxyl ortho cycloalcoxyl ortho thioxy ortho aryloxy ortho sulfones ortho sulfides ortho sulfoxides ortho sulfonates ortho sulfonamides ortho amino ortho amido ortho halo ortho carboalkoxy ortho carbothioalkoxy ortho trihaloalkane ortho cyano ortho nitro meta alkyl meta cycloalkyl meta alcoxyl meta cycloalcoxyl meta thioxy meta aryloxy meta sulfones meta sulfides meta sulfoxides meta sulfonates meta sulfonamides meta amino meta amido meta halo meta carboalkoxy meta carbothioalkoxy meta tri haloalkane meta cyano meta nitro para alkyl para cycloalkyl para alcoxyl para cycloalcoxyl para thioxy para aryloxy para sulfones para sulfides para sulfoxides para sulfonates para sulfonamides para amino para amido para halo para carboalkoxy para carbothioalkoxy para trihaloalkane para cyano or para nitro r 2 is either hydrogen or alkyl with 1 to 9 carbon atoms and for the sake of clearness the following terminology will be adopted for chloridrate derivatives lassbio 767 corresponds to the derivative of general formula ii where r 1 corresponds to acetyl r 2 is hydrogen x is chloride and n is equal to 9 lassbio 768 corresponds to the derivative of general formula ii where r 1 corresponds to h r 2 is hydrogen x is chloride and n is equal to 9 lassbio 822 corresponds to the derivative of general formula ii where r 1 corresponds to t butoxycarbonyl r 2 is hydrogen x is chloride and n is equal to 9 lassbio 795 corresponds to the derivative of general formula ii where r 1 corresponds to acetyl r 2 is methyl x is iodine and n is equal to 9 and lassbio 783 corresponds to the derivative.