and 40 ml of acetonitrile were introduced this mixture was cooled to 16 u00b0 c in an ice salt bath to this mixture 10 62 g 113 6 mmol of fuming sulfuric acid containing 25 of sulfuric anhydride was dropwise added at 13 u00b0 to 17 u00b0 c in a period of 1 5 hour the mixture was left for 1 5 hour to return to room temperature an hplc analysis of the contents revealed that 21 2 of cis oxazoline derivative iv r ch 3 had been generated while no trans amide derivative iii 39 r ch 3 y oh was detected then 72 ml of water was added thereto the resulting mixture was treated in the same manner as example 8 to yield 5 62 g yield 49 8 of cis u00b1 1 aminoindan 2 ol v as a white crystal its purity determined by an hplc was 98 7 into a 100 ml four neck flask 4 48 g 30 3 mmol of trans u00b1 1 2 indandiol ii and 40 ml of acetonitrile were introduced this mixture was suspended while this suspension was stirred at room temperature 6 14 g 60 6 mmol of 97 sulfuric acid was added thereto at room temperature in a period of 20 minutes the temperature within the mixture increased from 19 u00b0 c to 35 u00b0 c the slurry was completely dissolved to form a slightly yellow transparent solution the solution was stirred at 24 u00b0 c for 1 hour and then at 60 u00b0 c for 1 hour an hplc analysis of the contents revealed that 70 8 of cis oxazoline derivative iv r ch 3 had been generated while no trans amide derivative iii 39 r ch 3 y oh was detected.