biological or medical response of a subject in need thereof that is being sought by the researcher veterinarian medical doctor or other clinician in some embodiments the subject in need thereof is a mammal in some embodiments the mammal is human the present invention concerns also processes for preparing the compounds of the invention the compounds according to the invention can be prepared analogously to conventional methods as understood by the person skilled in the art of synthetic organic chemistry schemes 1 2 3 and 4 set forth below illustrate how the compounds according to the invention can be made it should be noted that the brief description on each of the arrows for each conversion has been added for illustration purpose sonly and should not be regarded as limiting with respect to the sequence of each individual step the following abbreviations are used in the general schemes and in the examples it is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention claimed as used herein the use of the singular includes the plural unless specifically stated otherwise it will be readily apparent to those skilled.