in a mammal or may diagnose the efficacy of a treatment the immunoassay may be a radioimmunoassay western blot assay immunofluorescent assay enzyme immunoassay chemiluminescent assay immunohistochemical assay and the like and may be performed in vitro in vivo or in situ standard techniques known in the art for elisa are described in u201c methods in immunodiagnosis u201d 2nd edition rose and bigazzi eds john wiley amp sons 1980 campbell et al u201c methods and immunology u201d w a benjamin inc 1964 and oellerich m 1984 j clin chem clin biochem 22 895 u2013 904 conventional methods for immunohistochemistry are described in harlow and lane eds 1988 in u201c antibodies a laboratory manual u201d cold spring harbor press cold spring harbor n y ausbel et al eds 1987 in current protocols in molecular biology john wiley and sons new york n y biological samples appropriate for such detection assays include but are not limited to cells tissue biopsy whole blood plasma serum sputum cerebrospinal fluid pleural fluid urine and the like the antibodies or antigen binding fragments of the present invention may also be used in immunotherapy the antibodies or antigen binding fragment thereof is provided to a mammal in an amount sufficient to prevent lessen or attenuate the severity extent or duration of the cancer all articles and patents referred to are incorporated herein by reference while the invention is described above in relation to certain specific embodiments it will be understood that many variations are possible and that alternative materials and reagents can be used without departing from the invention in some cases such variations and substitutions may require some experimentation but will only involve routine testing the foregoing description of.