layer of example i ______________________________________a inner medicated bioadhesive layer polyoxyethylene homopolymer 57 00 polyox wsr 301 hydroxypropyl cellulose n f 28 40 klucel mf polyethylene ac 6a 4 75 propylene glycol u s p 2 85 polyethylene glycol 400 1 90 bht f c c 0 10 benzocaine u s p 5 00 100 00b outer protective barrier layer hydroxypropyl cellulose 78 00 klucel mf ethyl cellulose 20 00 polyethylene glycol 400 2 00 100 00______________________________________ part a was extruded on a johnson extruder followed by subsequent extrusion and lamination of part b to a samples were applied to oral lesions and provided profound anesthetic effects lasting several hours within minutes of application the identical two layer laminate may also be made by coextruding the inner medicated bioadhesive layer part a and the outer protective barrier layer part b through separate die slots within a coextruder and laminating the two layers together four variations of a single layer bioadhesive film were made as shown below ______________________________________ingredients 1 2 3 4______________________________________polyethylene oxide homo 59 10 54 00 59 70 58 20polymer polyox wsr 301 hydroxypropyl cellulose 29 45 26 91 29 75 29 00 klucel hf ethyl cellulose 4 93 4 50 4 98 4 85propylene glycol u s p 2 96 2 70 2 99 2 91polyethylene glycol 400 1 97 1 80 1 99 1 94bht f c c 0 09 0 09 0 09 0 10phenol u s p 1 50 dyclonine hcl.