5 gm followed by benzaldehyde 2 3 g and the mixture was stirred at room temperature overnight after filtration the filtrate was treated with boc 2 4 3 g and dmap 0 35 g and stirred for about 1 hour the mixture was then washed with 5 aqueous citric acid then 5 nahco 3 and then dried over mgso4 after evaporation of solvent the residue was dissolved in ethanol 50 ml pd oh 2 600 mg acetic acid 1 ml and cyclohexene 3 ml were added and hydrogenation was carried out overnight the mixture was filtered through a celite pad and the filtrate was evaporated in vacuo to dryness to produce 3 3 boc n metyhlpropanediamine as a colorless liquid 2 3 g mass spec electrospray 189 1 to a solution of 6 allyl dihydrolysersic acid 150 mg prepared according to the procedure disclosed in ep 0 003667 and 3 3 boc n methyl propanediamine 150 mg in dmf 5 ml was added diisopropylethylamine 175 u03bcl followed by diethylcyanophosphonate 150 u03bcl and the mixture was stirred at room temperature overnight volatile substances were removed in vacuo to dryness the residue was partitioned between chcl 3 and water the organic layer was then washed with aqueous nahco 3 and dried over mgso 4 solvent was removed in vacuo to give 6 allyl 8 u03b2 3 3 boc n methyl aminopropyl carbamoyl ergoline 6 allyl 8 u03b2 3 3 boc n methyl aminopropyl carbamoyl ergoline from the previous step was treated with 30 tfa in dichloromethane for 30 minutes and volatile substances were removed in vacuo to dryness yielding 250 mg of 6 allyl 8 u03b2 3 n methyl aminopropyl carbamoyl ergoline.