10 minutes a solution of 1 azabicyclo 3 2 1 octane 5 methanamine 1 41 g 10 mmol in anhydrous tetrahydrofuran 10 ml was added and the mixture was stirred for 18 hours at room temperature and for 5 hours at 50 u00b0 c then concentrated in vacuo the residue was partitioned between 3n sodium hydroxide 100 ml and toluene 150 ml containing a little 2 propanol and the organic layer was separated the aqueous solution was extracted with toluene 100 ml containing a little 2 propanol and the combined organic solution was washed with saturated sodium chloride dried na 2 so 4 and concentrated in vacuo the residue was filtered through alumina eluted with 20 methanol tetrahydrofuran concentrated in vacuo and triturated from ether to afford 2 63 g 75 of the title compound as a colorless solid mp 97 u00b0 102 u00b0 c for purification a solution of the title compound 2 58 g 7 0 mmol in methanol 10 ml was treated with a solution of fumaric acid 1 39 g 12 mmol in methanol 20 ml the mixture stirred for 5 minutes and diluted with anhydrous ether 100 ml the suspension was cooled 0 u00b0 c and filtered the residue was washed with ether and dried in vacuo to afford 2 93 g 86 of the fumarate salt of the title compound mp 173 u00b0 175 u00b0 c analysis calc for c 18 h 26 cln 3 o 3 c 4 h 4 o 4 c 54 60 h 6 25 n 8 68 found c 54 30 h 6 41 n 8 68 a.