such actuation modules are known as such in various embodiments for example in connection with hand held devices for tattooing of for applying permanent make up normally the actuation module provides a linear to and fro movement at an operating frequency which in the embodiment in fig1 a and 12 b is coupled to the actuation plunger 32 that moves back and forth a further embodiment of a mechanically actuated device for the repeated penetration of a tissue in order for example to apply a substance is set out in fig1 a 13 b 13 c and 13 d in a comparable manner with the embodiment in fig1 a and 12 b the shown module can be detachably connected to the actuation device not shown as shown in fig1 a and 13 b two operating arms 46 which interact via guide pins 42 with an actuation element 44 of a mechanically actuated actuation plunger 45 are moveably borne in a housing 42 the application tools 1 2 u2014 in this case in needle form and guided on a tool guiding element 40 which simultaneously acts as a tissue penetration block u2014 are formed on a tool holder 47 at the front ends of the operating arms 46 the application tools 1 2 shown in an initial position before penetration in fig1 a during the forward movement of the actuation plunger 45.