peptide synthesis or by extraction from human fluid by methods well established in the art the calcitonin for use in the instant invention can be any calcitonin including natural synthetic or recombinant sources thereof as well as calcitonin derivatives such as 1 7 asn eel calcitonin various calcitonins including salmon pig and eel calcitonin are commercially available and commonly employed for the treatment of e g paget 39 s disease hypercalcemia of malignancy and osteoporosis the calcitonin can comprise a single calcitonin or any combination of two or more calcitonins the preferred calcitonin is synthetic salmon calcitonin the calcitonins are commercially available or may be obtained by known methods the amount of pth to be administered is generally an amount effective to stimulate new bone formation i e a therapeutically effective amount this amount will necessarily vary with the age size sex and condition of the subject to be treated the nature and severity of the disorder to be treated and the like however the amount can be less than that amount when a plurality of the compositions are to be administered i e the total effective amount can be administered in cumulative dosage units the amount of pth can also be more than the effective amount when the composition provides sustained release of the pharmacologically active agent the total amount of pth to be used can be determined by methods known to those skilled in the art however in general satisfactory results will be obtained systemically at daily dosages of from about 0 001 u03bcg kg to about 10 mg kg animal body weight preferably 1 u03bcg kg to about 6 u03bcg kg body weight the appropriate dosage of calcitonin to be administered will.