or substances may include any source of osteogenesis bone growth promoting materials bone bone derived substances or products demineralized bone matrix mineralizing proteins ossifying proteins bone morphogenetic proteins hydroxyapatite genes coding for the production of bone and bone including but not limited to cortical bone antibiotics cancer treating substances infection treating substances or other disease treating substances the implant can include at least in part materials that are bioabsorbable and or resorbable in the body the implants of the present invention can be formed of a porous material or can be formed of a material that intrinsically participates in the growth of bone between adjacent vertebral at least a portion of the implant may be treated to promote bone ingrowth between the implant and the adjacent vertebral bodies the implant of the present invention may be used in combination with a spinal fixation device such as any device regardless of material that can be inserted into any portion of the spine such as but not limited to interbody spinal implants structural bone grafts mesh cages spacers staples bone screws plates rods tethers of synthetic material or wires or other spinal fixation instrumentation while the invention has been described with reference.