objectives of the study was to compare the three regimens in terms of the safety profile including the body weight of the patients the trial was a multi centre multi national open label 1 1 1 randomised three arm parallel group clinical trial of 16 weeks of treatment comparing the efficacy and safety of insulin detemir administered at 12 hour intervals insulin detemir administrated morning and bedtime and nph insulin administered morning and bedtime in patients with type 1 diabetes all patients received insulin aspart at meals the trial included a screening visit to assess patient 39 s eligibility and a randomisation visit followed by a treatment period 16 of weeks a post treatment follow up visit was carried out approximately 1 week after the last visit the study included 409 type 1 diabetic patients aged 18 or above and hba 1c u2266 12 the patients had had diabetes gt 12 months and had been treated on a basal twice daily bolus regimen u2267 2 months using an intermediate long acting insulin as a basal insulin and fast acting human insulin or insulin analogue as bolus insulin anova of weight kg after 16 weeks of treatment u2014 adjusted for change in hba 1c itt overall test n mean se p value detemir 12 h_interval 131 75 20 0 22 nph morn_bed 122 76 04 0 23 detemir morn_bed.