49 300 69______________________________________ ii dose of sodium percentage inhibition of oleanolate mg kg aspirin induced gastric damage______________________________________ 30 1 100 30 300 47______________________________________ a dose related inhibition of the gastric damage was found as follows ______________________________________ percentage inhibition ofdose of oleanolic indomethacin inducedacid mg kg gastric damage______________________________________ 10 61 30 66100 80300 86______________________________________ the low acute toxicity of oleanolic acid is illustrated by the fact that doses up to 4000 mg kg did not cause any deaths in mice when administered by oral route influence of oleanolic acid on gastric damage caused by administration of resperine in rats the animals were treated with oleanolic acid per os tragacanth vehicle and directly thereafter with reserpine 6 mg kg subcutaneous injection after 16 hours the extent of gastic damage was determined treating the animals with oleanolic acid at a dose of 100 mg kg resulted in a 25 inhibition of reserpine induced gastric damage compared with an untreated control group influence of oleanolic acid on gastric damage hcl gastrin ulcer caused by administration of tetragastrin in rats each animal was treated with hydrochloric acid 0 2 ml of a 20 solution per os on day zero from day one onwards to day 14 the animals were treated once daily with tetragastrin 100 u03bcg kg day intraperitoneal injection and twice daily with the protective compound 100 mg kg treatment per os in tragacanth on day 15 the extent of gastric damage was determined in this test oleanolic acid brought about 49 inhibition of gastric damage and cimetidine a 41 reduction of gastric damage compared with an untreated control group healing effect of oleanolic acid on thermally induced ulceration in rats thermal stomach ulceration was induced on day zero by means of a heated 75 u00b0 c stainless steel stamp.