antibody optimally also will comprise at least a portion of an immunoglobulin constant region fc typically that of a human immunoglobulin u201c de immunized u201d antibodies are immunoglobulins that are non immunogenic or less immunogenic to a given species de immunization can be achieved through structural alterations to the antibody any de immunization technique known to those skilled in the art can be employed one suitable technique for de immunizing antibodies is described for example in wo 00 34317 published jun 15 2000 an antibody which induces u201c apoptosis u201d is one which induces programmed cell death by any means illustrated by but not limited to binding of annexin v caspase activity fragmentation of dna cell shrinkage dilation of endoplasmic reticulum cell fragmentation and or formation of membrane vesicles called apoptotic bodies as used herein u201c antibody induced cytotoxicity u201d is understood to mean the cytotoxic effect derived from the hybridoma supernatant or antibody produced by the hybridoma deposited with the idac as accession number 141205 04 which effect is not necessarily related to the degree of binding throughout the instant specification hybridoma cell lines as well as the isolated monoclonal antibodies which are produced therefrom are alternatively referred to by their internal designation ar53a10 11 or depository designation idac 141205 04 as used herein u201c antibody ligand u201d includes a moiety which exhibits binding specificity for at least one epitope of the target antigen and which may be an intact antibody molecule antibody fragments and any molecule having at least an antigen binding region or portion thereof i e the variable portion of an antibody molecule e g an fv molecule fab molecule fab u2032 molecule f ab u2032 sub 2 molecule a bispecific.