device one or more images of the sample in spatial coordination with the fiducial marker and defining n computer retrievable two dimensional or three dimensional image slices 3diss n is an integer greater than or equal to 2 c assigning by at least one second imaging device u201c likelihood u201d of malignancy or pathology of any kind for each of the n 3diss d defining from the n sdiss m suspected computer retrievable three dimensional image slices siss m is an integer greater than or equal to 0 and e preparing a i manual and or ii cad based slicing program the physical slicing of the extracted and pre analyzed biopsy is provided by slicing the sample according to the siss it is another embodiment of the invention to disclose the method as defined in any of the above wherein the aforesaid steps of spatially labeling the sample are provided by placing the fiducial marker i into and or ii onto the surface of the sample it is another embodiment of the invention to disclose the method as defined in any of the above wherein the aforesaid step of spatially labeling the sample is provided by one or more of the following physically incorporating a physical imageable member and or radiation emitting absorbing agents introducing biological active agents such as enzymes proteins and antigens antibodies interacting one or more chemical materials and compositions thereof such as reactants and the like and or by a computer generated.