of the synthesis involves the sequential removal of the fmoc group under standard conditions such as 50 piperidine morpholine or piperazine in dcm or dmf affording 7 peptide and amide bonds may be formed by reacting 7 with a carboxylic acid halide or a mixed anhydride and a tertiary amine acid scavenger or alternatively by combining 7 and a carboxylic acid or protected amino acid with a wide variety of coupling reagents that are standard to the art of peptide chemistry sulfonamides are similarly prepared by reacting 7 with a sulfonyl chloride and tertiary amine cleavage of the t butyl ester in 8 by treatment with tfa in dcm gives 9 which is subsequently cleaved from the resin by treatment with formaldehyde and dilute hcl to afford 10 a compound of formula i str14 according to scheme 2 the synthesis may also start with n u03b1 fmoc glutamic u03b1 carboxamide u03b3 t butyl ester 11 which is dehydrated to the nitrile through the use of a carbodiimide reagent such as dcc dic or edac to afford 12 removal of the t butyl ester protecting group with tfa in dcm gives 13 which is subsequently coupled to a solid support using a mixed anhydride method such as 2 6 dichlorobenzoyl chloride pyridine or isobutylchloroformate n methylmorpholine in dcm or dioxane solvent to afford 14 solid supports are those common to solid phase peptide synthesis including but not limited to wang resin merrifield resin and 2 chlorotrityl resin the remainder of the synthesis proceeds in a manner analogous to scheme 1 to afford 17 which.