filling into a suitable vial or ampul and sealing advantageously adjuvants such as a local anesthetic preservative and buffering agents can be dissolved in the vehicle to enhance the stability the composition can be frozen after filling into the vial and the water removed from vacuum the dry lyophilized powder is then sealed in the vial and an accompanying vial of water for injection is supplied to reconstitute the liquid prior to use parenteral suspensions are prepared in substantially the same manner except that the compound is suspended in the vehicle instead of being dissolved and sterilization cannot be accomplished by filtration the compound can be sterilized by exposure to ethylene oxide before suspending in the sterile vehicle advantageously a surfactant or wetting agent is included in the composition to facilitate uniform distribution of the compound rectal suppositories as used herein mean solid bodies for insertion into the rectum which melt or soften at body temperature releasing one or more pharmacologically or therapeutically active ingredients pharmaceutically acceptable substances utilized in rectal suppositories are bases or vehicles and agents to raise the melting point examples of bases or vehicles include for example cocoa butter theobroma oil glycerin gelatin carbowax polyoxyethylene glycol and appropriate mixtures of mono di and triglycerides of fatty acids combinations of the various bases may be used agents to raise the melting point of suppositories include for example spermaceti and wax rectal suppositories may be prepared either by the compressed method or by molding the usual weight of a rectal suppository.