many wound healing studies this method involves subcutaneous implantation of cotton pellets and measuring the size of the granuloma induced after a few days anti inflammatory agents reduce the size or weight of granuloma as compared with that of the control those compounds which promote healing increase the size or weight of the granuloma growth of granulation tissue into cotton pellets was induced by subcutaneous implantation at two symmetrical dorsolateral sites of sprague dawley male rats weighing 120 u00b1 5 g under ether anesthesia the cotton pellet implanted on the right side contains the compound under test and the cotton pellet implanted on the left side serves as the control the compound was introduced to the pellet as its ether solution the ether was completely evaporated before implantation on the seventh day after implantation the animals were killed with ether and the body weights were taken the granulomas were carefully removed and weighed rapidly on a torsion balance after drying in an oven at 65 u00b0 c for 48 hours the dried slices were weighed the following results were obtained __________________________________________________________________________effect of 3 39 7 39 desmethyl retinoic acidvinylogs on cotton pellet inducedgranuloma in rats__________________________________________________________________________ granuloma expt granuloma expt wet wt mg control dry wt mg control no of acids expt expt group animals applied control control__________________________________________________________________________i 6 a 238 6 u00b1 12 1 29 0 u00b1 2 1 220 5 u00b1 12 2 1 1 27 2 u00b1 2 1 1 1ii 14 b 331 1 u00b1 14 8 43 1 u00b1 2 6 208 8 u00b1 5 9 1 5 25 5 u00b1 1 5 1 7iii 43 c 430 2 u00b1 8 1.