6 mmol was added to the reaction mixture at 0 u00b0 c after stirring overnight the reaction mixture was extracted with water and washed with brine the organic phase was dried and evaporated the residue was purified with flash chromatography using ethyl acetate dcm 30 70 solvent to give a colorless oil 45 yield 0220 1 h nmr cdcl 3 u03b4 2 75 dd 1h 2 89 t 1h 2 99 s 3h 3 33 3 36 m 1h 3 88 dd 1h 4 24 dd 1h 6 70 dd 1h 6 81 dt 1h 7 16 7 23 m 2h 7 52 s 1h compound 16c s 0 364 g 1 5 mmol and 3 4 dichloropenylethylamine 0 284 g 0 11 ml 1 5 mmol were dissolved in 5 ml ethanol and refluxed for 10 hours then solvent was evaporated and the residue purified by flash chromatography using dichloromethane methanol 90 10 solvent to give the product 55 yield 0222 1 h nmr cdcl 3 u03b4 2 75 2 95 m 6h 3 01 s 3h 3 96 dd h u03b1 1h 3 97 s h u03b2 1h 3 99 4 05 m 1h 6 71 dd 1h 6 75 dd 1h 6 82 t.