chloride and extracted with ethyl acetate the extract was dried and evaporated in vacuo the residue was purified by flash chromatography to afford 11 in 79 yield as a white powder the acetal 11 was mixed with concentrated hydrochloric acid and stirred for several hours the mixture was extracted with a water immicible organic solvent the extract was washed with saturated aqueous nahco 3 dried and evaporated in vacuo to afford 12 the nitrile 12 was mixed with concentrated sulfuric acid and heated to 100 u00b0 c for several minutes the mixture was cooled poured onto ice and filtered to afford 13 one equivalent of the chloropyridine 13 was dissolved in 1 2 dimethoxyethane one equivalent of 3 chloro 2 methylphenylboronic acid was added a solution of one equivalent of sodium carbonate in water was added along with a catalytic amount of tetrakis triphenylphosphine palladium 0 the mixture was heated to 80 u00b0 c for several hours the mixture was poured into water and extracted with a water immiscible organic solvent the extract was dried evaporated in vacuo and purified by flash chromatography to afford 14 one equivalent of the alcohol 14 was dissolved in thf the solution was cooled to 0 u00b0 c and one equivalent of methanesulfonyl chloride was added following by one equivalent of triethylamine the solution was stirred for several hours poured into water and extracted with a water immiscible solvent the extract was dried and evaporated in vacuo to afford the crude mesylate 15 one equivalent of the methanesulfonyl ester 15 was dissolved in thf the solution was cooled to 0 u00b0 c and one equivalent of n ethyl piperazine was added.