samples in some instances a large proportion of these will be populated and in others relatively few will in those instances in which relatively few sample points are populated the specimen will include predefined u201c anchor u201d points to aid the system locating the probe template positions in those instances in which a large proportion of the potential sample sites are populated the samples themselves provide a sufficient population to position the probe templates and anchor points may be unnecessary at block 216 probe templates of the defined size with the defined grid spacing are generated and superimposed over the working specimen image at this point the operator can optionally provide a manual adjustment to the superimposed grid of probe templates in order to bring them into general alignment with the actual specimens he could do so for example by utilizing a mouse to shift the entire array then u201c grab specific probe templates and center them over the appropriate targets on the specimen the operator might for example perform a general alignment by centering the probe templates in the four corners of the grid over the appropriate targets of the specimen although not essential this manual adjustment will speed.