no 46 loop of hcdr3 of 3hfl pdb with loop of lcdr1 of 1qfw pdb respectively that has the highest binding activity is indicated by an arrow fig1 this loop loop peptide pair is derived from an anti lysozyme antibody and an anti human choriogonadotrophin antibody the results shown in fig1 shows that particular pairs of synthetic cdrs show better binding to lysozyme than other pairs especially group c therefore loop loop combinations of synthetic loops representing different cdrs of different antibodies not necessarily derived from the original antibody which in this example is an anti lysozyme antibody can be used to identify lead synthetic compounds that mimic antibodies construction of a double loop mimic of a discontinuous epitope fig1 two peptides that constitute two separate parts of a discontinuous epitope were coupled to the surface of a minicard as described above in the legend of fig1 cf fig3 a and fig4 example 4 a cys mmt was coupled alone or in combination with a cys trt in a 1 1 ratio and or val mmt the cys and val in a 1 1 1 3 1 9 etc ratio in this way one peptide was coupled squares a and c or two peptides with increasing valines in between the cysteines were coupled squares b and d cf fig4 b example 4 fig1 these four configurations were incubated with two different antibodies antibody 1 recognized when the individual loop peptides are coupled as a single loop only loop peptide 2 antibody 2 recognized when the individual loop peptides are coupled as a single loops only loop peptide 1 when the two.