ml was heated to reflux overnight the solvent was evaporated and the residue partitioned between ethyl acetate and saturated nahco 3 the organic layer was dried and concentrated and the residue purified by flash column chromatography 30 ethyl acetate in hexane to give 47 1 6 g 78 in a manner similar to that described in example 1 step 3 47 1 6 g 4 3 mmol was converted to 48 1 5 g 100 in a manner similar to that described in example 1 step 2 48 0 38 g 1 1 mmol was converted to 49 0 15 g 35 mass spectrum 475 m h to a suspension of 32 0 5 g 1 14 mmol in acetonitrile 5 ml was added diisopropylethylamine 0 59 g 4 56 mmol followed after 10 min by 50 0 23 g 1 37 mmol the mixture was stirred at room temperature for 48 h the acetonitrile was removed xylene 10 ml was added and the reaction refluxed overnight the reaction was cooled diluted with ethyl acetate and washed with water the organic layer was dried and concentrated and chromatographed 10 to 20 meoh in ethyl acetate to give 51 0 13 g 25 mass spectrum 463 m h a solution of 25 0 13 g 0 27 mmol in 1 1 5 hcl in dme water 4 ml was heated to 60 u00b0 c for 6 h the reaction was cooled.