a vacuum oven over drying agent for 4 days to give 2 2 chloro 3 methoxy phenyl 4 4 5 5 tetramethyl 1 3 2 dioxaborolane 7a as a white powder 746 7 g 2 78 mol 85 compound 1b 80 g 0 19 mol 7a 60 22 g 0 22 mol hp t bu 3 bf 4 13 01 g 44 85 mmol and pd 2 dba 3 13 69 g 14 95 mmol were charged to the reaction vessel and purged with an inert atmosphere degassed thf 560 ml was added followed by naoh 31 45 g 0 56 mol in degassed water 128 8 ml and the reaction warmed to 45 u00b0 c after 2 hours acetic acid 56 ml was added and stirred for 15 minutes after settling the layers were separated and the organic layer was filtered through celite rinsing with hot thf 2 u00d7 160 ml the filtrate was concentrated in vacuo to a slurry to which was added n acetyl cysteine 15 84 g as a solution in water 160 ml and ethanol 640 ml and stirred for 2 hours at 75 u00b0 c under an inert atmosphere the slurry was cooled to rt and the solids filtered off washed with ethanol water 8 2 2 u00d7 160 ml to give 5 2 chloro 3 methoxy phenyl 1 2 fluoro 6 methyl benzyl 6 methyl 1h pyrimidine 2 4 dione 7b as a.