reaction solution was separated the aqueous phase was extracted with dichloromethane three times and the organic phases were combined washed with saturated brine dried over anhydrous sodium sulfate and concentrated to give the target compound 2 4 g yield 90 1 hnmr 300 mhz cdcl 3 u03b4 7 3 7 5 5h m 7 2 1h t j 7 6 15 3 6 7 6 9 3h m 5 0 2h s 3 4 1h m 3 3 1h m 2 8 1h m 2 7 1h m 1 7 1 8 1h m 1 5 1 6 1h m 1 1 3h d 6 8 0 9 3h t j 7 3 14 5 esi ms 301 2 m u2212 h the product of example 42 2 4 g 8 mmol was dissolved in n n dimethylformamide potassium carbonate 2 7 g 20 mmol and dimethylamine hydrochloride 0 7 g 8 mmol were added therein then it was reacted at room temperature for 12 hours after that the reaction solution was poured into water the aqueous phase was extracted with dichloromethane twice then the organic phases were combined washed with saturated brine dried over anhydrous sodium sulfate concentrated and separated through silica gel column chromatography to give target 2 2 g yield 90 the product of example 32 2 6 g 9 mmol was dissolved in dichloromethane and the mixture was cooled in an ice water bath then 48 hydrobromic acid 0 54 ml 10 mmol was added dropwise after the addition was complete it was reacted at room temperature for 16 hours after that water was added therein for separating the aqueous phase was extracted with dichloromethane three times then the organic phases were combined washed with saturated brine dried over anhydrous sodium sulfate and.