e is also specific for pluripotent stem cells of the colon crypt fig6 which are the undifferentiated cells from which colorectal tumors originate their expression pattern indicates that the latter virtually disappears as the pluripotent cells are transformed into epithelial cells goblet cells in a normal crypt to form the epithelium so that it could be regarded as a marker of cell differentiation table 3 shows the levels of over expression of hcap e in colorectal cancer according to the staging the incidence of over expression was 90 18 out of 20 tumors only one case was observed in which expression was below normal u2212 and one case in which normal tissue and tumor tissue showed similar expression levels the expression levels of other proteins forming the condensin complex such as hcap c hcap d2 hcap d3 hcap g hcap g2 and hcap h were likewise analyzed by real time pcr as were other associated proteins that interact with the complex such as kif4a in certain tumors in which over expression of hcap e had been observed the results indicated that all the analyzed proteins showed increased expression levels in tumor tissue in comparison with the levels in normal tissue fig7 it is therefore concluded that all the proteins that make up the condensin complex and other proteins interacting with the complex are over expressed in tumors accordingly.