veterinary medicine animal sciences and such the term u201c individual u201d refers to human subjects and non human subjects who are disease or condition free and also includes human and non human subjects diagnosed with one or more diseases or conditions as defined herein u201c co morbid individuals u201d or u201c comorbidity u201d or u201c individuals considered as co morbid u201d are individuals who have more than one disease or condition as defined herein for example a patient diagnosed with both osteoarthritis and hypertension is considered to present with comorbidities as used herein u201c detecting u201d refers to determining the presence of a gene expression product for example cdna rna or est by any method known to those of skill in the art or taught in numerous texts and laboratory manuals see for example ausubel et al short protocols in molecular biology 1995 3rd ed john wiley amp sons inc for example methods of detection include but are not limited to rna fingerprinting northern blotting polymerase chain reaction ligase chain reaction qbeta replicase isothermal amplification method strand displacement amplification transcription based amplification systems nuclease protection s1 nuclease or rnase protection assays as well as methods disclosed in wo88 10315 wo89 06700 pct us87 00880 pct us89 01025 as used herein a disease of the invention includes but is not limited to blood disorder blood lipid disease autoimmune disease arthritis including osteoarthritis rheumatoid arthritis lupus allergies juvenile rheumatoid arthritis and the like bone or joint disorder a cardiovascular disorder including heart failure congenital heart disease rheumatic fever valvular heart disease.