2 and 14 especially between 8 5 and 12 5 such as between 8 5 and 11 5 most preferably between 9 5 and 11 5 such as about 9 5 9 6 9 7 9 8 9 9 10 0 10 1 10 2 10 3 10 4 10 5 10 6 10 7 10 8 10 9 11 0 11 1 11 2 11 3 11 4 or 11 5 around each ltb 4 particle when water is adsorbed to the particles of the mixture or when water is added in small amounts to the mixture in another preferred embodiment the alkaline u201c micro ph u201d ranges between 8 0 and 9 0 between 8 5 and 9 5 between 9 0 and 10 0 or between 10 0 and 11 5 such substances creating said u201c micro ph u201d can be chosen among but are not restricted to substances such as the sodium potassium calcium magnesium and aluminium salts of phosphoric acid carbonic acid citric acid or other suitable weak inorganic or organic acids substances normally used in antacid preparations such as aluminium calcium and magnesium hydroxides magnesium oxide or composite substances such as al 2 o 3 6mgo co 2 12h 2 o mg 6 al 2 oh 16 co 3 4h 2 o mgo al 2 o 3 2sio 2 nh 2 o or similar compounds organic ph buffering substances such as trihydroxymethylaminomethane or other similar pharmaceutically acceptable ph buffering substances any suitable type or mode of administration may be employed for providing a mammal especially a human with an effective dosage of ltb 4 for example oral parenteral intraduodenal intrajejunal and topical may be employed dosage forms include tablets capsules powders solutions dispersions suspensions creams ointments and aerosols in a.