73 ms es m e 424 m h a mixture of the product of step 3 67 mg 0 16 mmol 2 bromopyridine 61 mg 0 38 mmol sodium t butoxide 53 mg 0 55 mmol bis diphenylphosphino propane 16 mg 0 039 mmol and palladium ii acetate 7 mg 0 03 mmol in toluene 4 ml was heated at 100 u00b0 c in a sealed vessel for 16 h the mixture was diluted with ch 2 cl 2 40 ml and filtered the filtrate was evaporated to dryness and subjected to ptlc 3 97 meoh ch 2 cl 2 to give the product 36 mg 45 ms es m e 501 m h reaction of the product of step 4 with hcl meoh by the procedure of example 5 step 4 afforded the product 13 mg 48 1 h nmr 400 mhz cdcl 3 u03b4 8 16 1h m 7 99 1h s 7 90 1h m 7 53 1h m 7 47 2h m 7 34 1h s 6 68 1h m 6 63 1h m 6 51 1h m 4 17 2h m 3 83 2h m 2 79 2h m ms es m e 371 m h a mixture of preparation 3 0 693 g 1 40 mmol 3 fluorophenylboronic acid 0 410.