14 the absolute structure of salinosporamide a and confirmation of the overall structure of salinosporamide a was achieved by single crystal x ray diffraction analysis see example 3 the present invention also provides articles of manufacture including packaging material and a pharmaceutical composition contained within the packaging material wherein the packaging material comprises a label which indicates that the pharmaceutical composition can be used for treatment of disorders and wherein the pharmaceutical composition includes a compound according to the present invention thus in one aspect the invention provides a pharmaceutical composition including a compound of the invention wherein the compound is present in a concentration effective to treat cell proliferative disorders the concentration can be determined by one of skill in the art according to standard treatment regimen or as determined by an in vivo animal assay for example pharmaceutical compositions employed as a component of invention articles of manufacture can be used in the form of a solid a solution an emulsion a dispersion a micelle a liposome and the like wherein the resulting composition contains one or more invention compounds as an active ingredient in admixture with an organic or inorganic carrier or excipient suitable for enteral or parenteral applications compounds employed for use as a component of invention articles of manufacture may be combined for example with the usual non toxic pharmaceutically acceptable carriers for tablets pellets capsules suppositories solutions emulsions suspensions and any other form.