cirrhotic rat however after cirrhotic rat was administered with 30 mg kg of oltipraz 3 times a week for 4 weeks the expression of c ebp u03b1 was noticeably recovered because of the evident activity of c ebp found in the oltipraz administered cirrhotic rats next test quantified the amount of c ebp translocated into the nucleus in primary cultured hepatocytes by utilizing western blot method to test the direct effect of oltipraz on the c ebp activity at liver cells when the primary cultured hepatocytes were incubated with oltipraz at the concentration of 30 u03bcm the amount of c ebp u03b2 and c ebp u03b1 in the nucleus of the liver cells gradually increased fig7 a however when the hepatocytes isolated from cirrhotic rats were incubated with oltipraz no significant change was observed such result demonstrated that oltipraz directly triggers c ebp activity afterwards to study whether oltipraz promotes translocation of c ebp u03b2 to the nucleus rat hepatocytes were incubated with oltipraz at the concentration of 30 u03bcm for 6 hours according to the immunocytochemical analysis oltipraz clearly promoted translocation of c ebp u03b2 to the nucleus fig7 b therefore the regeneration of the liver tissues by oltipraz is accompanied by c ebp activation as demonstrated in the foregoing oltipraz can effectively regenerate cirrhotic liver tissues.