of pd l was added and the reaction mixture was stirred at 100 u00b0 c for 16 hours then 0 2 eq of pd l and 1 3 eq of 2 aminopyridine were added and the reaction mixture was stirred at 100 u00b0 c for 24 hours after filtration through celite and evaporation the resulting crude product was purified by scx column with meoh acoh 90 10 then meoh and dcm meoh nh 3 90 9 1 and finally by semiprep uplc to afford n 5 1 4 methoxybenzyl 1h pyrazol 4 yl 1 2 4 thiadiazol 3 yl pyridin 2 amine 0 30 mmol 110 mg 37 according to scheme 2 step 4 a solution of n 5 1 4 methoxybenzyl 1h pyrazol 4 yl 1 2 4 thiadiazol 3 yl pyridin 2 amine 69 mmol 25 mg in tfa 686 u03bcl was microwaved for 5 minutes at 120 u00b0 c the reaction mixture was neutralized with a solution of naoh 1 m and was extracted with dcm the organic phase was dried over mgso 4 was filtered and was concentrated the resulting crude product was purified by flash chromatography over silica gel using dcm etoh nh 3 100 0 0 to 90 9 1 as eluent to yield 5 1h pyrazol 4 yl n pyridin 2 yl 1 2 4 thiadiazol 3 amine 13 mmol 3 3 mg 19 as a yellow solid according to scheme 3 step 1 a solution of 2 chloro n pyridin 2 yl acetamide hydrochloride.