and prevents clogging of the downstream channels and chambers due to the presence of the debris additional lysate filters may be arranged in series and or in parallel to facilitate processing of multiple samples contacting loops 9 allow cell lysate to interact with nucleases delivered from nuclease solution loop 7 for example dnase may be delivered from nuclease solution loop 7 to degrade dna for isolation of rna or rnase may be delivered from nuclease solution loop 7 to degrade rna for isolation of dna other embodiments may include one or more of dnase rnase or protease loops for example depending on the type of molecule being isolated capture chamber 11 is loaded through bead injection port 12 with beads magnetic or non magnetic functionalized to bind to nucleic acids or other target biomolecules and maintained in a fluidized state the beads are held in the capture chamber by bead containment membranes 10 and are maintained in a fluidized state by fluidic flow or by using electric fields generated using electrodes located in the capture chamber bead containment membranes 10 are preferably asymmetric membranes having a smaller pore size e g 0 8 u03bcm on the bead side and a larger pore size e g 10 u03bcm on the port side the surface area of the membranes exposed to fluid flow is preferably maximized to minimize fluidic resistance and each membrane is preferably supported by a structure incorporated into each membrane mount to prevent membrane collapse the capture chamber 11 lacks sharp corners and contains fluidized beads functionalized to bind selected targeted cellular contents such as rna dna and proteins in one preferred embodiment the capture chamber is circular in shape.