y v r 1 and r 2 are as described herein the compounds have utility as antiproliferative agents especially as anticancer agents application_number US 68574810 A description racemic 2 u2032 s 3s 4 u2032 r 6 chloro 4 u2032 5 chloro 2 1 methoxycarbonyl 1 methyl ethoxy pyridin 3 yl 2 u2032 5 fluoro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6 u2032 1h dione racemic 2 u2032 s 3s 4 u2032 r 6 chloro 4 u2032 5 chloro 2 1 hydroxycarbonyl 1 methyl ethoxy pyridin 3 yl 2 u2032 5 fluoro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6 u2032 1h dione chiral 2 u2032 s 3s 4 u2032 r 6 chloro 4 u2032 5 chloro 2 1 hydroxycarbonyl 1 methyl ethoxy pyridin 3 yl 2 u2032 5 fluoro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6 u2032 1h dione racemic 2 u2032 s 3s 4 u2032 r 4 u2032 5 chloro 2 2 methanesulfonylamino 1 1 methyl 2 oxo ethoxy pyridin 3 yl 6 chloro 2 u2032 5 fluoro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6 u2032 1h dione chiral 2 u2032 s 3s 4 u2032 r 4 u2032 5 chloro 2 2 methanesulfonylamino 1 1 methyl 2 oxo ethoxy pyridin 3 yl 6 chloro 2 u2032 5 fluoro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6 u2032 1h dione racemic 2 u2032 s 3s 4 u2032 r 6 chloro 4 u2032 5 chloro 2 1 methoxycarbonyl 1 methyl ethoxy pyridin 3 yl 2 u2032 5 chloro 2 methyl phenyl spiro 3h indole 3 3 u2032 piperidine 2 6.