mono and di alkylamino groups include ethylamino dimethylamino and methyl propyl amino the term u201c substituted u201d as used herein means that any one or more hydrogens on the designated atom or group is replaced with a selection from the indicated group provided that the designated atom 39 s normal valence is not exceeded when the substituent is oxo i e u2550 o then 2 hydrogens on the atom are replaced when an oxo group substitutes aromatic moieties the corresponding partially unsaturated ring replaces the aromatic ring for example a pyridyl group substituted by oxo is a pyridone combinations of substituents and or variables are permissible only if such combinations result in stable compounds or useful synthetic intermediates a stable compound or stable structure is meant to imply a compound that is sufficiently robust to survive isolation from a reaction mixture and subsequent formulation into an effective therapeutic agent unless otherwise specified substituents are named into the core structure for example it is to be understood that when aminoalkyl is listed as a possible substituent the point of attachment of this substituent to the core structure is in the alkyl portion suitable groups that may be present on a u201c substituted u201d or u201c optionally substituted u201d position include but are not limited to e g halogen cyano hydroxyl nitro azido alkanoyl such as a c 2 c 6 alkanoyl group carboxamide alkyl groups including cycloalkyl groups having 1 to about 8 carbon atoms or 1 to about 6 carbon atoms alkenyl and alkynyl groups including groups having one or more unsaturated linkages and from 2 to about 8 or 2 to about 6 carbon atoms.