
{"publication_number": "US-2010249393-A1", "abstract": "the present invention provides for reagents for the introduction of colorimetric - oxycarbonyl protecting groups , compounds bearing colorimetric - oxycarbonyl protecting groups , and the use thereof in solid - supported organic syntheses of oligonucleotides , polypeptides , polysaccharides , and combinatorial libraries .", "application_number": "US-41428809-A", "description": "the present invention provides methods and compositions for use in the synthesis of organic compounds . in particular the present invention provides for protecting groups which are typically calorimetric when cleaved from a reaction product . despite the popularity of oxycarbonyl protecting groups , triarylmethyl protecting groups , and calorimetric analyses , a calorimetric protecting group that contains both oxycarbonyl and triarylmethyl functionalities would be useful in the art . this combination provides a useful protecting group for heteroatoms . in certain embodiments , the combination has the property of providing a calorimetric signal when cleaved . both the triarylmethyl group and the oxycarbonyl group are typically stable under basic conditions but are subject to cleavage under acidic conditions , also known as acid deprotection . cleavage of the triarylmethyl group provides the calorimetric signal that is useful in the monitoring of solid - supported syntheses . the acid sensitivity of illustrative examples of triarylmethyl groups typically follows the order { least acid sensitive . . . ( 4 - clph ) 3 \u2014& lt ; tr -& lt ; mmt -& lt ; dmt - . . . most acid sensitive 