domains in a single polypeptide molecule moreover an antigen binding fragment of an antibody of the present invention may comprise a homo dimer or hetero dimer or other multimer of any of the variable and constant domain configurations listed above in non covalent association with one another and or with one or more monomeric v h or v l domain e g by disulfide bond s as with full antibody molecules antigen binding fragments may be monospecific or multispecific e g bispecific a multispecific antigen binding fragment of an antibody will typically comprise at least two different variable domains wherein each variable domain is capable of specifically binding to a separate antigen or to a different epitope on the same antigen any multispecific antibody format including the exemplary bispecific antibody formats disclosed herein may be adapted for use in the context of an antigen binding fragment of an antibody of the present invention using routine techniques available in the art in certain embodiments antibody or antibody fragments of the invention may be conjugated to a therapeutic moiety u201c immunoconjugate u201d such as a cytotoxin a chemotherapeutic drug an immunosuppressant or a radioisotope the term u201c specifically binds u201d or the like means that an antibody or antigen binding fragment thereof forms a complex with an antigen that is relatively stable under physiological conditions specific binding can be characterized by an equilibrium dissociation constant k d of about 3000 nm or less i e a smaller k d denotes a tighter binding.