means two entities e g a tumor targeting peptide and a reporting agent are associated with sufficient affinity that the therapeutic diagnostic benefit of the association between the two entities is realized conjugation can be achieved by covalent or non covalent bonding as well as by other forms of association such as entrapment of one entity on or within the other the targeting molecules can be a small peptide and or protein the small peptide includes but is not limited to arg gly asp rgd asn gly arg ngr cyclic nor disulfide based cyclic rgd irgd lyp 1 gastrin bombesin octreotide or derivate thereof the protein includes but is not limited to epidermal growth factor egf anti egfr antibody vascular endothelial growth factor vegf anti vegfr antibody anti her2 antibody hepatocyte growth factor receptor hgfr anti hgfr antibody tumor necrosis factor tnf or anti tnf antibody in one embodiment the targeting molecules can be conjugated with a bioimaging molecule s or radio radiotherapeutic agent s radioactive nuclide radiopharmaceuticals or isotope to form a conjugate radioactive molecules suitable for in vivo imaging include but are not limited to 122 i 123 i 124 i 125 i 131 i 18 f 75 br 76 br 76 br 77 br 211 at 225 ac 177 lu 153 sm 186 re 188 re 67 cu 213 bi 212 bi 212 pb or 67 ga exemplary radiopharmaceuticals suitable for in vivo imaging include 111 in oxyquinoline 131 i sodium iodide 99m tc mebrofenin and 99m tc red blood cells 123 i sodium iodide 99m tc exametazime 99m tc macroaggregate albumin 99m tc medronate 99m tc mertiatide 99m tc oxidronate 99m tc pentetate 99m tc pertechnetate 99m tc sestamibi 99m tc sulfur colloid 99m te tetrofosm in thallium 201 or xenon 133 isotope include but are.