fig5 a statistical analysis using the mann whitney u test revealed that ks patients had significantly lower anti k8 1 antibody titers than mcd ks p 0 009 mcd ks u2212 p 0 008 or the pel patients p 0 013 also the difference between the anti k8 1 antibody titers in ks versus the combined mcd ks and mcd ks u2212 patient groups was highly significant p 0 0008 the gmt of the late lytic antigen orf65 in the 35 ks patients was 34 380 lu 95 ci 12 570 94 050 and was significantly lower p lt 0 006 than the gmt of 1 010 000 lu 95 ci 317 300 3 214 000 for the pel patients data not shown the mcd ks and mcd ks u2212 patients showed variable antibody titers and were not significantly different from the ks patients data not shown antibody titers were also evaluated against two latent antigens v cyclin and lana orf73 the anti v cyclin in gmt in the ks patients was 225 900 lu 95 ci 128 600 396 900 which was markedly higher than the gmt of 10 840 lu 95 ci 1964 59 840 in the mcd ks patients p 0 0004 or 6 751 lu 95 ci 1446 31 530 for the mcd ks u2212 patients p 0 0006 as shown in fig5 b the difference between the anti v cyclin antibody titers in ks versus the combined mcd ks and mcd ks u2212 patient groups was also highly significant p lt 0 0001 the gmt for the pel patients was 51 563 lu 95 ci 2943 903 400 which trended lower than the gmt for the ks patients p 0.