46 sc 47 sc 48 ga 72 and ga 73 while the invention has been described with respect to specific examples including presently preferred modes of carrying out the invention those skilled in the art will appreciate that there are numerous variations and permutations of the above described systems and techniques that fall within the spirit and scope of the invention as set forth in the appended claims compounds were syntheszied using the witting horner reaction see fig1 these stable tetrahederal phosphorus species act by mimicking the tetrahedral intermediates of the reactions catalyzed by the rdp enzyme we report here the synthesis and biological evaluation of new rdp inhibitors the method employed for the preparation of aminophosphinic acid derivatives is outlined in fig1 compound 1 was prepared by the condensation of cyclohexylacetaldehyde hypophosphoric acid and aminodiphenylmethanehydrochloride 11 followed by protection of the nh 2 and p u2014 oh groups with boc and ch 2 n 2 12 respectively reaction of 1 with trimethyl 2 phosphonoacrylate in the presence of naome as base gave an intermediate which subsequently underwent a wittig horner olefination 13 with aldehydes to give mixtures of e and z isomers which were separated by column chromatography over silica gel the yields were 30 40 for the z isomers and 20 30 for the e isomers the protecting groups were removed by treatment with cf 3 cooh followed by conc hcl 12 and the crude products were purified by.