2 n n diethylformylamidino 4 2 aminoethyl thiomethyl thiazole in 18 ml ethanol is added 0 97 g of dimethyl n cyanoimidodithiocarbonate and stirred overnight at room temperature and the reaction mixture is evaporated under reduced pressure to give the desired product material from step 1 in an amount of 0 78 g is dissolved in 40 methanol containing 1 9 g of methylamine and stirred overnight the residue after evaporation of the reaction mixture is applied to silica gel column chromatography using ethyl acetate ethanol 2 1 solution as eluent to give 0 59 g of the desired oily product to a solution of 1 0 g of material from step 1 of example 1 in 20 ml ethanol is added 0 6 g of silver nitrate and 4 79 g of n propylamine and then stirred overnight the organic phase is filtered from insoluble residue and the filtrate is evaporated the residue is fractionated by column chromatography using 30 g of silica gel and ethyl acetate as eluent to give 0 75 g of an oily product ir 3250 3040 2950 2550 2160 1730 1690 1620 cm 1 according to the procedure of example 2 but substituting an equivalent amount of cyclohexylamine for the n propylamine in part an oily product is obtained using 2 n n dimethylamidino.