
{"publication_number": "US-2010249416-A1", "abstract": "the present invention concerns a new molecule , i - 124\u03b2cit iodine - 124 - tropane ] and its process of synthesis , for use in pet investigations .", "application_number": "US-68243108-A", "description": "to a 1 ml vial closed with a diffusion barrier and in inert atmosphere , we add , in the following order : 5 mci of na 124 i in a solution of 500 \u03bcl of naoh 0 . 05 n ; 50 \u03bcg of trialkylstanyl precursor ([ 2\u03b2 - carbomethoxy - 3\u03b2 -( 4 - tributylstannylphenyl ) tropane ] or [ 2\u03b2 - carbomethoxy - 3\u03b2 -( 4 - trimethylstannylphenyl ) tropane ]) dissolved , sonicating for 3 minutes , in 150 \u03bcl of ethanol ; 50 \u03bcl of h 3 po 4 0 . 5 n ; 50 \u03bcl of ch 3 co 3 h 0 . 02 m prepared at the moment of use by 100 \u03bcl 32 % of peracetic acid dissolved in 2 . 4 ml of water . after 30 minutes at ambient temperature in an inert atmosphere , we add 100 \u03bcl nahso 3 in a solution prepared by dissolving 10 mg in 1 ml . we wait 5 minutes , after which we add 500 \u03bcl of a solution saturated with nahco 3 , we transfer the activity onto a c18 sep - pak light cartridge ( preconditioned with 5 ml of ethanol and 5 ml of water for injectables ) with a flow of 1 ml / min . we wash the c18 sep - pak light cartridge with 20 ml of sterile water with a flow of 4 ml / min , and we elute the product with 7 ml of a solution at 50 % of ethanol / sterile water with a flow of 1 ml / min , after which the product is passed through a 0 . 22 \u03bcm sterile filter and diluted with saline solution ."