brain concentration for both exemplary compounds is reached about 1 hr after gavage although compound j147 has improved ability to be retained in the brain relative to 11 011 perhaps due to the increased hydrohpobicity of the former six hr after administration the majority of test compound in blood and in brain has been eliminated thus these results show that exemplary compounds according to the invention can be orally absorbed and traverse the blood brain barrier preliminary sar analysis of j147 using the tfw mc65 and ht 22 oxytosis assays preliminary sar analyses were carried out on the series of compounds set forth below based on the following generic structure the present example demonstrates the ability of invention compounds to alter activity of a kinase or a phosphatase which is involved in phosphorylation of the neuroprotective transcription factor cyclic amp binding protein creb creb activation has been linked to cell survival and accordingly is considered to be a validated therapeutic target vaishnov et al biochem biophys res commun 307 855 860 2003 similar to the concept of programmed cell death which involves transcription factors pivotal in switching on the nerve cell death program is the transcriptional control of programmed cell life for example recent studies of the activation of the creb transcription factor in stroke models have shown that creb is phosphorylated and presumably activated in neurons that survive this insult further studies show that the creb survival pathway.