1989 molecular cloning a laboratory manual 2nd ed cold spring harbor press n y a gene and its transcription control sequences are defined as being u201c operably linked u201d if the transcription control sequences effectively control transcription of the gene vectors of the invention include but are not limited to plasmid vectors and viral vectors preferred viral vectors of the invention are those derived from retroviruses adenovirus adeno associated virus sv40 virus or herpes viruses as used herein the term u201c host u201d is meant to include not only prokaryotes but also eukaryotes such as yeast plant and animal cells a recombinant dna molecule or gene which encodes a human hepsin protein of the present invention can be used to transform a host using any of the techniques commonly known to those of ordinary skill in the art especially preferred is the use of a vector containing coding sequences for the gene which encodes a human hepsin protein of the present invention for purposes of prokaryote transformation prokaryotic hosts may include e coli s tymphimurium serratia marcescens and bacillus subtilis eukaryotic hosts include yeasts such as pichia pastoris mammalian cells and insect cells the term u201c oligonucleotide u201d as used herein is defined as a molecule comprised of two or more ribonucleotides preferably more than three its exact size will depend upon many factors which in turn depend upon the ultimate function and use of the oligonucleotide the term u201c primer u201d as used herein refers to.