was separated out and dried over na 2 so 4 the solvent was removed by evaporating under reduced pressure and the product i was purified as described in table 2 thionyl chloride socl 2 9 3 ml 0 128 moles was added to a suspension of a convenient substituted 1h indazole 3 carboxylic acid compound i 2 36 g 0 0123 moles in toluene 77 ml and the reaction mixture was refluxed for 4 hours the solvent was removed by evaporation under reduced pressure and the residue was taken up twice in toluene to give 2 13 g of the desired product xiii 2 10 substituted 7h 14h pyrazino 1 2 b 4 5 b u2032 di indazole 7 14 dione to a suspension of xiii 5 2 mmol in toluene 40 ml a solution of the convenient amine compound ii 2 1 eq and triethylamine tea 3 6 eq 2 6 ml was added drop wise the mixture reaction was refluxed for 8 hours then cooled and stirred in 2n hcl 20 ml for 8 hours the suspension was transferred in a separating funnel and aqueous phase was separating out and made alkaline with 1n naoh the solvent was removed by evaporating under reduced pressure and the product i was purified as described below for example compound 3 can be prepared following method c described below thionyl chloride socl 2 9.