chloride 1 75 g 0 033 mole and sodium azide 2 1 g 0 033 mole was added and the mixture refluxed at 120 u00b0 c for 24 hours at which point the mixture was evaporated to dryness in vacuo the solid mixture was partitioned with 30 ml of water 10 ml of concentrated ncl and ethyl acetate the organic phase was separated washed three times with brine dried over mgso 4 filtered and concentrated in vacuo the residue crystallized when triturated with ethyl acetate and skelly b to yield 4 g 55 theory m p 174 u00b0 175 u00b0 c anal calcd for c 16 h 19 n 5 o c 55 63 h 5 54 n 20 28 found c 54 81 h 5 68 n 20 18 the compounds prepared as described above were tested for anti hypertensive activity in rats and cats using the following procedures the acute antihypertensive activity of test compounds was determined in rats made hypertensive by the procedure of a grollman proc soc exper biol med 57 102 1944 by applying a figure of eight ligature to one kidney and removing the contralateral kidney two weeks later at least four weeks after the second operation the rats were subjected to indirect systolic blood pressure measurements with an occluding cuff and pulse sensor applied to the tail measurements were made before and at 1 2 4 6 and 8 hours after the oral administration of the test compounds at a dose of 10 mg kg each compound was tested initially in five rats and if it elicited a significant decrease in pressure at any of.