of intermediate i 3 2 83 g 10 0 mmol of 4 bromoiodobenzene 0 18 g 0 2 mmol of pd 2 dba 3 0 04 g 0 4 mmol of ptbu 3 and 1 44 g 15 0 mmol of kotbu were dissolved in 40 ml of toluene to obtain a solution which was then stirred at about 85 u00b0 c for about 4 hours the reaction solution was cooled to room temperature followed by three times of extraction with 30 ml of water and 30 ml of diethylether the organic phase was collected and was dried using magnesium sulfate to evaporate the solvent the residue was separated and purified using silica gel column chromatography to obtain 2 04 g of intermediate i 4 yield 63 this compound was identified using lc ms c 17 h 13 brn 2 calc 324 0 found m 1 325 0 3 25 g 10 0 mmol of intermediate i 4 2 54 g 10 0 mmol of bis pinacolato diborone 0 36 g 0 5 mmol of pdcl 2 dppf 2 and 2 94 g 30 0 mmol of koac were dissolved in 40 ml of dmso to obtain a solution which was then stirred at about 80 u00b0 c for about 6 hours the reaction solution was cooled to room temperature followed by three times of extraction with 50 ml of water and 50 ml of diethylether the organic phase was collected and was dried using magnesium sulfate.