1 46 g 80 of n vanillylformamide ii 4 hydroxybenzaldehyde 1 22 g or 10 mmol formamide 22 72 g or 20 03 ml and formic acid 2 43 g or 2 ml were placed into a 50 ml round bottom flask equipped with a thermometer a reflux condenser a magnetic stirrer and a heating mantle the reaction mixture was heated to 189 u00b0 c the heating was immediately turned off the reaction flask was quickly raised from the heating mantle and allowed to cool to room temperature the tlc conducted on the cold reaction mixture confirmed that the reaction was complete the reaction mixture was diluted with 50 ml of water and extracted with ethyl acetate the extract was dried with sodium sulfate and the solvent was evaporated to produce 1 17 g 77 1 of 4 hydroxybenzylformamide iv one g 3 9 mmol of v 2 ml of formic acid and 20 ml of formamide were placed in a round bottom flask equipped with thermometer reflux condenser and a heating mantle the reaction mixture was heated to 188 190 u00b0 c and maintained at this temperature for 10 minutes the reaction mixture was left to cool to room temperature overnight the precipitated crystals were separated by filtration rinsed with water and dried with vacuum producing 70 of n 1 2 4 dichlorophenyl 4 4 dimethyl 1 propen 3 yl formamide vi the reaction procedure for v was repeated with 5 g of benzophenone and the reaction time of 15 minutes the reaction produced 95 of benzhydrylformamide viii isolated yield one g of vi 10 ml of concentrated hydrochloric acid and 10 ml of methanol were placed in the greenchem reaction vessel the greenchem reaction vessel was placed into the mars 5 reaction.