the data is reported as pmole cgmp generated per mg protein undesired hypotensive activity is also determined by known methods for example according to the methods of carron et al also cited above such selective neuroprotective antiischemic and excitatory amino acid blocking activities reflect the valuable utility of the present compounds in the treatment of stroke traumatic brain injury and degenerative cns central nervous system disorders such as alzheimer 39 s disease senile dementia of the alzheimer 39 s type parkinson 39 s disease and huntington 39 s disease without significant potential for a concurrent undue drop in blood pressure in the systemic treatment of such diseases with a neuroprotective amount of compounds of the formula i ii or iii the dosage is typically from about 0 02 to 10 mg kg day 1 500 mg day in a typical human weighing 50 kg in single or divided doses regardless of the route of administration 0f course depending upon the exact compound and the exact nature of the individual illness doses outside this range may be prescribed by the attending physician the oral route of administration is generally preferred however if the patient is unable to swallow or oral absorption is otherwise impaired the preferred route of.