
{"publication_number": "US-7189710-B2", "abstract": "the present invention relates to novel 2 - fluoro - pyrrolobenzodiazepine dimers useful as antitumour agents and to a process for the preparation thereof .", "application_number": "US-81284004-A", "description": "the present process provides a process for the preparation of bis 2 - fluoro pyrrolo [ 2 , 1 - c ][ 1 , 4benzodiazepines of formula ix as given above where n is 3 to 10 which comprises reacting ( 2s )- n -[ 4 - hydroxy - 5 - methoxy - 2 - nitrobenzoyl ]- 4 - fluoro - 2 - carboxaldehyde diethylthioacetal of formula vi with a dibromoalkane in an aprotic water miscible organic solvents . the solvent is preferably chosen from acetone , acetonitrile , and dmf . the reaction is also carried out in the presence of a mild inorganic bases such as k 2 co 3 , csco 3 and baco 3 and up to refluxing temperature for a period of 48 hours . the 1 , 1 \u2032-{[( alkane - 1 , n - diyl ) dioxy 