
{"publication_number": "US-6455524-B1", "abstract": "the present invention relates to new medicament compositions based on anticholinergic compounds , which have a long - lasting effect , and \u03b2 - mimetics , which have a long - lasting effect , processes for their production and their use in the therapy of respiratory ailments .", "application_number": "US-56888000-A", "description": "surprisingly , it has now been found that the above - mentioned side - effects can be substantially reduced by a combination of a \u03b2 - sympatho - mimetic , which has a long - lasting effect , with an anticholinergic , which has a long - lasting effect . in addition , it was also very surprisingly discovered that the bronchospasmolytic effects of the anticholinergic , which has a long - lasting effect , and the \u03b2 - mimetic , which has a long - lasting effect , increase in a superadditive manner . hence with the combination of active ingredients according to the invention , a substantial increase in effectiveness can be expected \u2014 in comparison to the individual substances and combinations known from the prior art \u2014 in the case of both copd and asthma . the following active ingredients can preferably be used as \u03b2 - mimetics , which have a long - lasting effect , in the active ingredients combination according to the invention : bambuterol , bitolterol , carbuterol , clenbuterol , fenoterol , formoterol , hexoprenalin , ibuterol , pirbuterol , procaterol , reproterol , salmeterol , sulfonterol , terbutalin , tolubuterol , 4 - hydroxy - 7 -[ 2 -{[ 2 -{[ 3 -( 2 - phenylethoxy ) propyl ] sulfonyl 