0 70 mmole of 6 aminohexanol 59 3 mg 0 43 mmoles of white drierite and 68 3 mg 0 27 mmole of mercuric cyanide according to the method of turgeon et al turgeon j et al drug metab disp 20 5 762 769 1992 a small amount of methanol and water was added in an attempt to achieve complete dissolution of the products the reaction mixture was stirred overnight in the dark at room temperature and the solvent was evaporated under vacuum 6 aminohexanol glucuronide was extracted with chloroform and the most important part of the product was collected in the organic phase the glucuronide was treated with 2 15 mg 39 8 u03bcmoles of sodium methoxyde in anhydrous methanol turgeon j et al drug metab disp 20 5 762 769 1992 the reaction proceeded at room temperature during 24 hours with agitation the last part consisted in joining the deprotected 6 aminohexanol glucuronide part to glutarylpaclitaxel synthesis of glutarylpaclitaxel glutaryltaxol has been described previously briefly paclitaxel was dissolved in pyridine and reacted with an excess of glutaric anhydride at room temperature for four to five hours pyridine was discarded when the mixture was applied on a silica reverse phase c 18 prep sep u2122 minicolumn j t baker phillipsburgh n j and the product was eluted with methanol the final step consisted in activating 0 6.