u03b2m group are significantly lower than those in the control group the iga and igm levels of the pp supernatant with lps in the 0 5 u03b2 group are lower than those in the control group but no statistical difference is found the igg contents among the control group the 0 5 u03b2 group and the 0 5 u03b2m group are not significantly different as above results the mice fed with 1 95 mg ml u03b2 glucan of the present invention for two weeks have the inhibition on the iga and igm secretion in the pp supernatant but have no effect on igg secretion compared with the secretion concentrations of three antibodies it is to find out the account of the igg secreted from the pp cells is a very small number which is indicated that igg is not a main antibody form in this immune system therefore the results show that the pharmaceutical composition of the present invention has the ability of decreasing the antibody secretion while treating with lps the effect of the pharmaceutical composition of the present invention on cytokine levels in the pp supernatant although b cells are major cell populations in peyer 39 s patches other cells such as dentritic cells dc or t cells as well as participate in the activation and maturation of the b cells via secreting cytokines for example the transforming growth.