of b wave after bleaching condition was measured for flash of 1 cd m u2212 2 sec u2212 1 and expressed as relative mean value compared to the amplitude of b wave measured before bleaching condition asterisks depict statistical significance p lt 0 05 fig2 partial recovery of the rod function following subretinal delivery of aa v2 1 cmv oa1 to oa1 u2212 mice amplitude of a a and b waves b in scotopic and photopic depicted by the arrows conditions mean u00b1 s e m from aav2 1 cmv oa1 empty triangles n 5 and aav2 1 cmv egfp black circles n 3 treated eyes recorded 1 month after vector delivery asterisks depict statistical significance p lt 0 05 fig3 rescue from delayed recovery from photoreceptor desensitization in oa1 u2212 mice treated with aav progressive recovery over time of the b wave amplitude following bleaching conditions in 2 a and 9 month b old oa1 u2212 animals injected subretinally either with aav2 1 cmv oa1 black circles n 6 eyes in both a and b or aav2 1 cmv egfp empty triangles n 6 eyes in a and 9 in b asterisks depict statistical significance p lt 0 05 fig4 increased density of normal sized stage iv melanosomes in the oa1 retinae transduced with aav representative electron micrographs of peripheral rpe in 2 months old treated and control oa1 u2212 retinae left panel shows the low melanosome density and macromelanosome presence typical of the oa1 u2212 rpe transduced with aav2 1 cmv egfp middle and right panels show different areas of the same rpe cell in.