the magnitude of an administrated dose in the management of the disorder of interest will vary with the severity of the condition to be treated and to the route of administration the severity of the condition may for example be evaluated in part by standard prognostic evaluation methods further the dose and perhaps dose frequency will also vary according to the age body weight and response of the individual subject a program comparable to that discussed above may be used in veterinary medicine although the exact dosage will be determined on a drug by drug basis in most cases some generalizations regarding the dosage can be made the daily dosage regimen for an adult human subject may be for example an oral dose of between 0 1 mg and 2000 mg of each active ingredient preferably between 1 mg and 500 mg e g 5 to 200 mg in other embodiments an intravenous subcutaneous or intramuscular dose of each active ingredient of between 0 01 mg and 100 mg preferably between 0 1 mg and 60 mg e g 1 to 40 mg is used in cases of administration of a pharmaceutically acceptable salt dosages may be calculated as the free base in some embodiments the composition is administered 1 to 4 times per day alternatively the compositions of the invention may.