mol of p toluenesulphonic acid monohydrate in 2 8 l of methanol is added to the suspension this is rinsed with 1 8 litres of methanol and cooled to 22 u00b0 c the precipitated potassium salt of p toluenesulphonic acid is separated off using a pressure filter and the filter cake is washed with 7 4 litres of methanol the filtrate is inoculated with the title compound and stirred overnight the precipitated product is suction filtered under argon washed with 3 7 l of methanol and recycled into the reactor while still damp 18 5 l of methanol are added and the suspension is refluxed for one hour and cooled to 22 u00b0 c the product is suction filtered under argon washed with 3 7 l of methanol and dried at 30 u00b0 c in a circulating air drier 2 22 kg 85 of theory of the title compound are obtained t m p 241 u00b0 c u00b1 5 u00b0 c decomposition dsc evaluated 5 0 g of r 2 4 amidinophenylaminomethyl 1 methyl 5 1 carboxymethylamino 1 pyrrolidinocarbonyl ethyl benzimidazole are refluxed in 25 ml of ethanol after the addition of 2 ml of water a solution is obtained the solution is filtered clear and the filter is rinsed with 25 ml of ethanol the filtrate is heated to 70 u00b0 c a solution of 0 802 ml of conc hydrochloric acid in 25 ml of ethanol is added and.