ii an aspect of the present invention relates to the adaptation of the reaction to the solid phase chemisty described herein wherein r 2a is a hydroxy substituted resin that is activated to form ester linkages of formula iii such as wang resin hydroxymethylbenzamide hmba am hmba pgeg a resin novasyn u00ae tg hmba resin or hydroxymethylpolystyrene resin preferably hmba am suitable conditions under which r 2a may be reacted with aqueous hydroxylamine preferably from about 20 to about 80 aqueous hydroxylamine include in an organic solvent such as methanol n n dimethylformamide dmf or tetrahydrofuran or in a mixture of organic solvents such as dmf methanol thf methanol or dmf methanol thf in the presence of from about 5 to about 50 mole percent preferably from about 20 to about 40 mole percent of a cyanide salt such as potassium cyanide sodium cyanide or the like at a temperature from about 0 to about 100 u00b0 c preferably at about 25 u00b0 c to form a hydroxamic acid of formula iv as shown in scheme 2 one skilled in the art will recognize that although the instant process is suitable for forming any hydroxamic acid esters of formula i and formula iii containing additional reactive functional groups may need to be protected using reagents and methods known to those skilled in the art see green t w wuts p.