purified u 230 is preferably dissolved in a first step in dilute acid preferentially hydrochloric or nitric acid a u 230 radiopharmaceutical for targeted radiotherapy is prepared as follows the radionuclide u 230 is mixed with a buffered solution of a chelated carrier molecule in e g using sodium acetate buffer at ph 5 7 and incubated for an appropriate time e g 1 hour purification of the u 230 radioconjugate can be performed using size exclusion chromatography or ion exchange procedures followed by sterile filtration a pharmaceutically acceptable carrier or excipient can be added and or a scavenging agent for the use of u 230 in pre targeted radiotherapy the radionuclide is mixed with a buffered solution of chelated biotin or another suitable carrier molecule and incubated for an appropriate time purification of the obtained u 230 radioconjugates can be performed using high performance liquid chromatography or ion exchange procedures and sterile filtration representative conditions for forming radioconjugates are given here to a solution containing u 230 in 0 2 m ammonium acetate ph 5 0 containing approximately 10 mg ml of ascorbic acid as a radioprotectant 2 u03bcg of chelated biotin in 1 u03bcl of 0 2 m ammonium acetate ph 5 0 are added the reaction mixture is incubated for 1 h after which 10 u03bcl of a solution containing 1 5 mg ml.