1 h 7 083 d j 8 2 h 6 942 m j 16 1 h 6 533 d j 5 6 1 h 6 402 d j 15 6 6 253 s 1 h 2 687 d j 4 8 3 h 2 440 s 3 h ms m e 418 2 m 1 dmso d 6 11 397 s 1 h 9 420 s 1 h 8 334 d j 5 6 1 h 7 290 s 1 h 7 241 d j 7 2 1 h 7 152 d j 8 8 1 h 6 919 m j 15 2 1 h 6 803 m j 15 6 1 h 6 652 d j 6 8 1 h 6 451 d j 5 6 1 h 6 218 s 1 h 2 860 s 3 h 2 795 s 3 h 2 449 m j 14 8 2 h 2 399 s 3 h 2 338 m j 14 8 2 h ms m e 434 2 m 1 a solution of n2 3 methoxylphenyl n4 2 methyl 1h indol 5 yl pyrimidine 2 4 diamine 0 1 mmol in 5ml ch 2 cl 2 was placed in an ice bath to this was added bbr 3 0 5 mmol the reaction mixture was stirred overnight at room temperature then poured into ice water and extracted with ethyl acetate the organic layer was washed sequentially with water and brine dried over anhydrous na 2 so 4 and concentrated the residue was purified by column chromatography to provide the desired product in a yield of 83 1 h nmr dmso d 6 400 mhz u03b4 10 501 s 1h 9.