compound of formula i suitable for buccal or sublingual administration include tablets lozenges and pastilles wherein the active ingredient is formulated with a carrier such as sugar and acacia tragacanth or gelatine and glycerin etc compositions of the present invention containing a compound of formula i and or geometric isomers and or stereoisomers and or diastereomers and or physiologically acceptable salts and or hydrates and or solvates thereof for rectal administration are conveniently in the form of suppositories containing a conventional supposiory base such as cocoa butter compositions of the present invention containing a compound of formula i and or geometric isomers and or stereoisomers and or diastereomers and or physiologically acceptable salts and or hydrates and or solvates thereof for transdermal administration include ointments gels and patches the compositions of the present invention containing a compound of formula i and or geometric isomers and or stereoisomers and or diastereomers and or physiologically acceptable salts and or hydrates and or solvates thereof is preferably in the unit dose form such as tablet capsule or ampoule each dosage unit of the present invention for oral administration contains preferably from 1 to 250 mg of a compound of formula i and or geometric isomers and or stereoisomers and or diastereomers and or physiologically acceptable salts and or hydrates and or solvates thereof calculated as a free base each dosage unit of the present invention for parenteral administration contains preferably from 0 1 to 25 mg of a compound of formula i and or geometric isomers and.