treatment is the use of sustained release systems that include drug supports in synthetic and natural materials the advantage of a sustained release system of antibiotic in the treatment of osteomyelities is the maintenance of a localized increase of the drug and thus a more effective control of bacterial and fungal growth other potential advantages include drug targeting improved compliance and comfort vancomycin hydrochloride vancocine u00ae solution of 8 mg ml was prepared in tris buffer solution ph 7 21 one milliliter of the drug solution was micropipetted on 0 2 g scpc particles c1s3 and c3s1 of grain size 300 425 u03bcm in 20 ml glass vials the particles were immersed in the drug solution and incubated at 37 u00b0 c for 24 hours the particles were then removed washed with 1 ml tris buffer solution ph 7 21 for 30 sec and dried at 37 u00b0 c overnight for comparison control samples c3s1 and c1s3 were immersed in drug free solution and run in parallel all samples were performed in triplicates to evaluate the kinetics of drug release from the scpc the scpc particles loaded with the drug were immersed in 12 ml of simulated body fluid sbf as described in example 1 and incubated at 370 c the sbf volume 12 ml was selected such that its ph does not change during immersion 2 ml of the sbf were withdrawn and replaced by another fresh 2 ml sbf after 1 3 6 24 and 48 h at 72 h 50 of the sbf were replaced day to day up to 4 weeks the concentration of vancomycin hydrochloride released from the scpc into the sbf was.