were analyzed experiment result shows that in forming period by multiple administration of cordyceps cicadae sample a or its stepwise extract b c d had no significant difference on the residence time in the accompanying box of the mouse induced by morphine but in withdrawal period after treatment with cordyceps cicadae sample a or stepwise extract sample b c the residence time in the accompanying box time was significantly lower than morphine group especially the residence time in the accompanying box of sample d is very significantly lower than morphine group suggesting that hea can be used in drug seeking behaviour after withdrawal and it had certain anti addiction fig8 a b male c57bl 6 mice 20 25 g after one week of adaptive feeding to the animals were randomly divided into eight groups sham operation group ir group hea 5 mg kg group hea 7 mg kg group hea 10 mg kg group dpcpx 1 mg kg group dpcpx 1 mg kg hea 5 mg kg group and dpcpx 1 mg kg hea 7 5 mg kg group the mouse was weighed before operation then peritoneally injected with pentobarbital sodium 50 mg kg to anaesthetize the mouse abdomen was opened by ventromedial incision blunt dissection and.