
{"publication_number": "US-2017137403-A1", "abstract": "a novel process is provided for the efficient preparation of an asymmetric compound of structural formula i : comprising a copper - catalyzed , carbon - nitrogen cross - coupling step . the process described as part of the present invention can be used to manufacture poly polymerase inhibitors , which may be useful for the treatment of cancer . in particular , the present invention describes a process for the manufacture of the parp inhibitor , 2 -- piperidin - 3 - yl ] phenyl 