9 to prepare 6 amino 4 3 chloro 4 3 fluorobenzyloxy anilino 3 cyano 7 ethoxyquinoline hydrochloride the reaction mixture from the previous step was taken as is and to it was added ethanol 1 6 l and concentrated hydrochloric acid 1 38 l to bring the ph to 1 3 the suspension was held at 70 75 u00b0 c for a minimum of 2 h after 1 h the mixture thickens and ethanol 0 80 l was added after 2 h water 6 80 l was added the mixture stirred for 1 h and then cooled to 35 45 u00b0 c and stirred overnight 12 h the mixture was filtered and rinsed with 1 1 ethanol water 2 u00d7 0 84 l at 35 45 u00b0 c the product was isolated as a wet cake and carried through to the next step to prepare 6 amino 4 4 benzyloxy 3 chloroanilino 3 cyano 7 ethoxyquinoline hydrochloride the wet cake from the previous step was taken as is and to it was added a 2 n solution of concentrated hydrochloric acid 1 16 l in methanol 5 84 l the suspension was heated to 63 68 u00b0 c and held for a minimum of 30 h the mixture was cooled to 20 30 u00b0 c filtered and rinsed with methanol 2 u00d7 0 30 l the product was isolated as.