by an antibody while the word immunogen is used for the entity that induces antibody production in some instances the antigen and immunogen are the same entity as where a synthetic polypeptide is utilized to induce production of antibodies that bind to the polypeptide antigenic determinant refers to the actual structural portion of the antigen that is immunologically bound by an antibody combining site the term is also used interchangeably with epitope immunoreact in its various forms is used herein to refer to binding between an antigenic determinant containing molecule and a molecule containing an antibody combining site such as a whole antibody molecule or a portion thereof mastoparan mastoparan derivatives mastoparan analogs and their grammatical variations as used herein include the peptides identified herein as seq id nos 1 5 their derivatives and analogs thereof with and without a terminal amino nh 2 group on the cooh terminal end of the polypeptide pharmaceutically acceptable physiologically tolerable and their grammatical variations as they refer to compositions carriers diluents and reagents are used interchangeably and represent that the materials are capable of administration to or upon a mammal without the production of untoward physiological effects such as nausea dizziness gastric upset and the like unit dose when used in reference to a therapeutic composition of the present invention refers to physically.