inhibition of papilloma virus infectivity using the c127 cell line with complete inhibition at 1 mg ml ds showed moderate inhibition at 100 u03bcg ml and very high inhibition at 1 mg ml clones were derived from the parental c127 cell line because of the consistent failure of bpv 1 to induce foci following several cell passages of the uncloned parental cell line one clone labeled c127 d10 which produced foci upon bpv 1 infection was chosen for a repeat testing of the compounds when this clone was tested for microbicidal activity less compound was required to achieve high reduction in bpv 1 induced foci when compared to the uncloned parental c127 cells pre incubation of c127 d10 cells with compounds prior to addition of bpv 1 was tested to determine whether the microbicidal effects of cs and ds extended to a blockage of virus interaction with cell surfaces in these experiments titrations of compounds were added to cell cultures followed by washing away unbound reagent prior to addition of virus after a one hour incubation with virus unbound virus was removed by washing and the cultures monitored for foci after two weeks the results table d indicated that these reagents showed some interference of virus with host.