to this solution were added 3 fluorophenylboronic acid 6 g 42 9 mmol and 5 pd c 50 wet 0 5 g the toluene solution of compound 38 from above was then added and the mixture was heated to 75 u00b0 c for at least 5 h at which time an hplc assay indicated complete reaction upon completion the reaction mixture was cooled to 25 u00b0 c and filtered to remove the pd c catalyst the layers were separated and the organic layer was washed and concentrated under reduced pressure to about 20 ml heptane 20 ml was slowly added seed crystals were added and the mixture was cooled to u2212 10 u00b0 c over 2 h the crystalline solid was filtered washed with heptane and dried overnight under vacuum at 30 u00b0 c to provide 8 g 75 mp 61 63 u00b0 c u03b4 1 3 t j 7 08 hz 3h 3 42 s 1h 3 49 s 1h 4 1 q j 7 08 hz 2h 7 04 7 11 m 1h 7 23 7 3 m 1h 7 32 7 3 m 1h 7 32 7 36 m 1h 7 39 7 48 m 1h 7 81 ddd j 8 08 2 3 0 41 hz 1h 8 74 d j 2 36 1h.