100 g was suspended in a 1 1 mixture of ethyl acetate and toluene 400 ml the suspension was heated to 60 u00b0 c for 1 hour with rapid stirring and then cooled to 15 u00b0 c the suspension was filtered to recover the lorazepam the lorazepam crystals were then washed with ethyl acetate 20 ml and dried under 65 mm hg vacuum at about 50 u00b0 c for about two hours to give crystalline lorazepam 83 g in 88 yield lorazepam ethanol solvate 100 g was suspended in dichloromethane 600 ml the suspension was heated to about 40 u00b0 c for 1 hour with rapid stirring and then cooled to 10 u00b0 c the suspension was filtered to recover the lorazepam crystals the crystals were washed with dichloromethane 20 ml and dried at 50 u00b0 c under 65 mm hg vacuum for two hours to give crystalline lorazepam 85 5 g 90 lorazepam ethanol solvate 100 g was suspended in a 1 1 mixture of dichloromethane and toluene 600 ml the suspension was then heated to 25 u00b0 c for one hour and then cooled to 15 u00b0 c the suspension was filtered to recover the lorazepam crystals the crystals were washed with toluene 20 ml and dried at 50 u00b0 c under 65 mm hg vacuum for two hours to give crystalline lorazepam 85 g 90 lorazepam methanol solvate 100 g was suspended in ethyl acetate 400 ml the suspension was heated to 60 u00b0 c for one hour with rapid stirring and then cooled to 15 u00b0 c the suspension was filtered to recover the lorazepam crystals the crystals were washed with ethyl acetate 50 ml and dried at 50 u00b0 c under 65 mm hg vacuum for two hours to give crystalline lorazepam 85 g.