and low price of pharmacological production technology the mixture of fosfomicin and bhsio 2 in weight ratio 10 1 30 1 and 50 1 is being processed for 1 2 or 4 hours in a rotary mill in table no 1 you will see the granulometric composition data for the water suspensions of the received compositions variations micro sizer 201 laser granulometer was used as well as helc analysis results which show their antibiotics content in from the initial substance and fosfomicin sorption degree in by bhsio 2 particles as can be seen from table no 1 the chosen conditions of the composition production afford to increase until a certain value not less than 25 from the total weight the part of the finely dispersed bhsio 2 fraction particles size less than 5 micron and to avoid the antibiotic chemical degradation there has been a research of fosfomycin mechanized for 2 hours and composed of a mixture antibiotic bhsio 2 in weight ratio 30 1 and 50 1 respectively to determine therapeutic efficiency of fosfamicin and their pharmaceutical compositions including bhsio 2 we used experimental sepsis models and a statistical processing methos of the received data u03c7 2 according to 29 30 microorganisms staphylococcus aureus atcc no 25923 f 49 escherichia coli atcc no 25922 f 50 pseudomonas.