heart b ultrasonography was performed after 4 weeks heart tissue was determined for apoptosis tunel method and expression levels of sirt1 and p53 western blot the ratio of left ventricular weight to body weight lvw bw is determined it can be seen from the results shown in fig3 to 5 that brl37344 decreases p53 expression cardiac cell apoptosis and value of lvw bw of heart failure rat increases sirt1 expression alleviate cardiac hypertrophy and improve cardiac function blockage of the u03b2 3 receptor could increase level of u03b2 galactosidase in adipose derived stem cells and promote stem cell aging brl37344 and sr59230a were used to treat adipose derived stem cells of rats each at 10 u2212 7 m after 24 h cells were fixed using paraformaldehyde and stained and photographed according to the specification of u03b2 galactosidase staining kit results were shown in fig6 brl37344 decreased the level of u03b2 galactosidase in adipose derived stem cells when compared with sr59230a indicating agonisting of adrenergic u03b23 receptors of adipose derived stem cells achieves anti aging effect activation of the u03b23 receptor could increase mtor rictor complex in mcf 7 cells shrna of u03b23 adrenergic receptor control shrna brl37344 and sr59230a were used to.