in dry thf 4 ml was added 74 mg 0 409 mmol 1 4 fluorophenyl piperazine and the reaction mixture was stirred at room temperature for 3 h 40 mg 0 124 mmol 4 phenyl piperidine 4 carboxylic acid s 1 phenyl propyl amide dissolved thf 2 ml was added the mixture was heated under reflux for 12 h the reaction mixture was subjected to flash chromatography with n heptane and ethyl acetate over a 20 g silica gel column to yield 62 mg 1 4 4 fluoro phenyl piperazine 1 carbonyl 4 phenyl piperidine 4 carboxylic acid s 1 phenyl propyl amide ms isp m e 529 3 100 m h in analogy to the procedure described for the synthesis of 1 4 4 fluoro phenyl piperazine 1 carbonyl 4 phenyl piperidine 4 carboxylic acid s 1 phenyl propyl amide example 231 the title compound was prepared from 4 phenyl piperidine 4 carboxylic acid s 1 phenyl ethyl amide cdi and 1 phenyl piperazine ms isp m e 497 5 m h in analogy to the procedure described for the synthesis of 1 4 4 fluoro phenyl piperazine 1 carbonyl 4 phenyl piperidine 4 carboxylic acid s 1 phenyl propyl amide example 231 the title compound was prepared from 4 phenyl piperidine 4 carboxylic acid s 1 phenyl ethyl amide cdi and 1 4 fluorophenyl piperazine ms isp m e 521 5 m h as mentioned earlier the compounds of formula i and their pharmaceutically usable addition salts possess valuable pharmacological properties it has been found that the compounds of the present invention are antagonists of neurokinin 3 nk 3 receptors the compounds were investigated in accordance with the tests given hereinafter the compounds were investigated.