a compound of formula 1 examples of suitable inert carriers are water aqueous buffers such as those which are generally useful in high performance liquid chromatography hplc analysis organic solvents such as acetonitrile ethyl acetate hexane and the like and pharmaceutically acceptable carriers or excipients more particularly the present invention contemplates pharmaceutical compositions comprising a therapeutically effective amount of a compound of formula 1 in admixture or otherwise in association with one or more pharmaceutically acceptable carriers or excipients the pharmaceutical compositions are prepared in a manner well known in the pharmaceutical art the carrier or excipient may be a solid semi solid or liquid material which can serve as a vehicle or medium for the active ingredient suitable carriers or excipients are well known in the art the pharmaceutical composition may be adapted for oral or parenteral use and may be administered to the patient in the form of tablets capsules suppositories solution suspensions or the like the compounds of the present invention may be administered orally for example with an inert diluent or with an edible carrier they may be enclosed in gelatin capsules or compressed into tablets for the purpose of oral therapeutic administration the compounds may be.