blend of polymer dissolved in a selected solvent the flow of the polymer solution may be controlled by pressure from gas source 4 micro nanofibers may be deposited on a tubular substrate using a mandrel or drum which may be rotated for a uniform coating on the cylindrical surface the fibers may be deposited on both sides or on one side of the substrate to increase microfibers penetration into pores of the substrate the fiber density should be at least 2 5 mg cm 2 to provide a tubular blood vessel with an improved mechanical strength and a cell attachment ability based on a completely biodegradable hydrophilic microfiber nano fibered ecm like matrix the material may contain two or more microfiber layers of different compositions different fiber sizes and different packing densities fig2 shows blood conduit 20 prepared from a completely biodegradable hydrophilic microfiber nano fibered ecm like matrix in accordance with one embodiment of the present invention as shown in fig2 blood conduit 20 includes layers that mimicked a natural blood vessel a innermost layer 21 mimicking u2018 tunica intima u2019 may be formed by a hydrophilic layer of pla plga plc or a mixture thereof and pvp middle layer 22 mimicking u2018 tunica media u2019 may be.