1h isoquinolin 2 yl 2 oxo ethyl 3 2 methyl pyrimidin 5 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 6 methyl pyridin 3 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 6 chloro pyridin 3 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 5 methyl pyridin 2 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 6 methoxy pyridin 3 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 5 methoxy pyridin 2 yl n 4 pyridin 2 yl benzyl acrylamide s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl n 4 pyridin 2 yl benzyl 3 2 trifluoromethyl pyrimidin 5 yl acrylamide and s u2014 n 1 benzyl 2 3 4 dihydro 1h isoquinolin 2 yl 2 oxo ethyl 3 1 5 dimethyl 1h pyrazol 4 yl n 4 pyridin 2 yl benzyl acrylamide further examples of preferred compounds of formula i are selected from the group consisting of s u2014 n 1 benzyl 2 3 4.