to cause hydrolysis after the termination of the reaction the reaction solution was neutralized concentrated and then purified by silica gel column chromatography to obtain 48 g of compound 3 as the desired compound 6 10 ppm 1h s 5 53 ppm 1h s 5 14 ppm 1h s 3 99 ppm 1h s 3 85 ppm 1h s 2 34 ppm 2h m 1 94 ppm 3h s 1 00 ppm 3h d 0 97 ppm 3h s 0 70 3h s synthesis of compound 4 r 1 oh r 2 oh r 3 h the reaction procedure of synthesis example 3 was followed except that 30 g of acrylic acid was used instead of methacrylic acid as a result 32 g of compound 4 was obtained 6 39 ppm 1h d 6 12 ppm 1h dd 5 79 ppm 1h d 5 16 ppm 1h s 3 99 ppm 1h s 3 85 ppm 1h s 2 33 ppm 2h m 0 99 ppm 3h d 0 97 ppm 3h s 0 70 ppm 3h s synthesis of compound 5 r 1 h r 2 oh r 3 ch 3 75 g of chenocholic acid and 1 l of dimethylformamide were charged in a 2 l three necked flask and then stirred at room.