drug for the therapy and or prevention of arteriosclerosis as a consequence of metabolic diseases or the process of aging there is a healing and or preventive effect as this pharmaceutical drug inhibits the migration of lymphocytes neutrophils and monocytes into the vessel wall thus inhibiting the progredience of arteriosclerotic plaque resulting therefrom the pharmaceutical drug according to the invention may also be used for the transportation of another drug the inventive drug specifically binds a surface molecule on endothelial cells thus drugs linked thereto may be delivered to endothelial cells in high concentrations without any danger of them having side effects at other sites an example that may be cited here is the use of substances inhibiting the division of cells which specifically brought to endothelial cells may have an antiangiogenetic effect this brings about a healing effect in tumor patients as tumor growth is blocked by preventing the proliferation of endothelial cells and thus by preventing neoangiogenesis the inventive compounds themselves may also develop an antiangiogenetic effect as they because of their endothelium stabilizing effect prevent the endothelial cells from changing into a proliferative phenotype and thus prevent the formation of new capillary blood vessels therefore they are themselves suitable for the treatment of all kinds of tumor diseases as well as the prevention and or treatment of tumor metastases the inventive compounds of formula i together with pharmaceutical adjuvants and additives may be formulated into pharmaceutical preparations which also are a subject matter of the present invention in order to prepare such formulations a therapeutically effective dose of the peptide or peptide derivative is mixed with pharmaceutically acceptable diluents stabilizers solubilizers emulsifying aids adjuvants or carriers and brought into a suitable therapeutic form such preparations for instance contain a dilution of various buffers e g tris.