of omeprazole or a magnesium salt of the u2212 enantiomer of omeprazole the latter having the generic name esomeprazole the active ingredient can for example be esomeprazole magnesium trihydrate or tenatoprazole or a pharmaceutically acceptable salt thereof or a single enantiomer of either of them being the active drug as another example the compound active ingredient can be a hydrated form of anyone of the aforementioned compounds active ingredients the amount of active ingredient in the preparation is in the range of 1 mg 100 mg 2 mg 80 mg or 5 mg 50 mg a second dosing unit is provided for metering a volume of the second component further means for introducing the components into the package receptacle are provided the shown system is to be used with a packaging machine for filling sachets with pellets and at least one additional component i e a recipient in the form of a powder the shown system allows for 100 determination of net fill weight independent on tare weights of the primary packaging receptacles and uses optimized adjustable dosing chamber 11 with feeding and discharge slides 10 12 the system uses a direct gravimetric mass determination e g a weighing cell the system is protected against influences by any machine vibrations or air turbulences the system can be run with production speed appropriate for pharmaceutical industry the fill weight is determined down to less than 10 mg with appropriate accuracy the system shown in the figures uses gravimetric force to convey pellets through the system feed back to the volumetric dosing system permits the system to adjust the dosing volume defective packages are identified and rejected as shown in fig1.