from teeth of each patient then they were instructed on cleaning according to the standard method u2014 with use of tooth threads and interdental brushes patients were divided into 3 groups group 2 u2014 10 patients used colgate toothpaste later on as well as chewing gum with dnase according to the example 4 u00bc plate was chewed during 30 minutes 4 times a day during 4 weeks group 3 u2014 10 patients used colgate toothpaste later on as well as varidase buccal tablets during 4 weeks silness loe index oral hygiene index and muellermann index sulcus bleeding index were evaluated before the beginning of research and by the end of it the research involved 16 patients with confirmed diagnosis u201c systemic lupus erythematosus u201d and symptoms of glomerulonephritis proteinuria microhematuria all the patients received a standard therapy nonsteroid anti inflamatory drugs chloroquine patients from the experimental group 8 persons were additionally treated with suppositories according to the example 3 the dose was 250000 kunz units per kg of the body mass in a day during 15 days dna concentration in plasma was studied before the start of treatment and by the end of treatment period dna content in plasma of control group patients had not reliably changed twice decrease of dna in plasma was revealed in patients of the experimental group by the end of 15 days treatment course the research involved 18 healthy volunteers u2014 men from 50 to 55 years old the patients were divided into 3 groups group 1 7 patients was treated with placebo capsules during 30 days group 2 6 patients was treated with capsules according to example 2 the daily dose was 35 000 kunz units per kg.