6 dideoxy 2 iodo u03b1 l manno hexopyranosyl adriamycinone compound 1 produces no evidence of cardiotoxicitiy when compared to the administration of similar regimens of doxorubicin hydrochloride in mice intradermal administration of compound 1 failed to cause extravasation development of skin ulcers intradermal administration of 7 o 3 4 di o acetyl 2 6 dideoxy 2 iodo u03b1 l mannohexopyranosyl 14 o 5 carboxypentanoyl adriamycinone compound 6 was responsible for substantially fewer lesions in comparison to those noted in animals adminstered doxorubicin hydrochloride groups of either mice or rats 10 group were injected intradermally with 0 1 ml of compound 1 suspended in cremaphor at concentrations of 2 mg ml or compound 6 suspended in saline at concentrations of 2 mg ml and 1 mg ml similar groups were given doxorubicin hydrochloride at identical concentrations as a positive control the animals were observed frequently for lesions the results are shown in table 2 table 2__________________________________________________________________________ number of animals with lesions dosage day 5 day 9 day 11 day 14 day 21__________________________________________________________________________mouse extravasationcompound 1 1 ml 2 mg ml 0 10 0 10 0 10 0 10 0 10doxorubicin 1 ml 2 mg ml 10 10 10 10 10 10 10 10 10 10cremophor control 1 ml 0 10 0 10 0 10 0 10 0 10rat extravasationcompound 6 1 ml 2 mg ml 2 10 1 10 1 10 0 10 0 10doxorubicin 1 ml 2 mg ml 6 10 9 10 9 10 8 10 8 10compound.