easton pa 1965 the compositions can be prepared by known techniques for the preparation of tablets capsules lozenges troches elixirs syrups emulsions dispersions wettable and effervescent powders sterile injectable compositions and can contain suitable excipients known to be useful in the preparation of the particular type of composition desired dosage units adaptable or oral administration such as tablets capsules lozenges elixirs syrups and the like are preferred and the active compound can be formulated in conventional timed release capsule or tablet formulations preferred compositions include sterile injectable solutions containing from about 0 001 to about 10 percent by weight of the compound in a pharmaceutical carrier suitable for injection such as isotonic saline solution ringer 39 s injection usp and lactated ringer 39 s usp and the like a group of four mice were administered 60 mg kg of the compound 6 chloro 3 2 dimethylamino ethyl 3 4 dihydro 4 hydroxy 4 phenyl 2 1h quinazolinethione example 7 by intraperitoneal injection via an aqueous carrier a similar group of mice serving as controls were injected only with the carrier after 30 minutes both groups of mice were injected subcutaneously with 2 5 mg kg of reserpine the administration of reserpine to the control mice resulted in a classical progression of symptoms beginning with a dropping of the eyelids ptosis and later culminating in a generalized depression with decreased spontaneous motor activity and decreased responsiveness to auditary and tacticle stimuli animals injected with the benzotriazepine compound were graded after 45 minutes on the following basis no ptosis 0 partial ptosis 1 complete ptosis 2 adding the grades for the four test mice gave a value of 4 out of a possible 8 or 50 protection against reserpine induced ptosis the value for the four.