animals were injected with su5416 20 mg kg sugen inc followed by 3 weeks hypoxia then followed by 2 10 weeks normoxia the peptide administered was a 7 amino acid variant to the car peptide used in previous examples this variant cark consisted of the following sequence carsknk seq id no 2 in these experiments cark was administered at a dose of 3 mg kg and fasudil administered at 1 mg kg to measure the acute effects of fasudil with and cark administration on the right and left ventricular systolic pressure or systolic aortic pressure blood pressure measurements were performed on catheterized su5w hypoxia normoxia exposed rats with pah similar to car cark co administration enhanced the blood pressure lowering effect of fasudil on rvsp with only a minor reduction in sap fig2 and lvsp fig2 as compared to fasudil alone interestingly administration of 10 mg kg of fasudil 30 minutes after cessation of cark infusion still resulted in a sustained pulmonary specific effect fig2 severe occlusive pah rat model was used animals were injected with su5416 20 mg kg sugen inc followed by 3 weeks hypoxia then followed by 2 10 weeks normoxia the peptide administered was car carsknkdc seq id no 1 in this experiment car was administered at a dose of 3 mg kg and imatinib administered at 10 mg kg to measure the acute effects of imatinib with car administration on the right and left ventricular systolic pressure blood pressure measurements were performed on catheterized su5w hypoxia normoxia exposed rats with pah similar to fasudil car co administration.