25 8 53 6 u00b1 3 5 65 8 63 8 u00b1 3 0 78 1tolbutamide 25 8 56 4 u00b1 5 9 69 2 68 2 u00b1 4 7 83 5control 8 83 4 u00b1 1 8 100 84 9 u00b1 3 1 100example 2 25 8 55 0 u00b1 5 2 66 0 60 6 u00b1 2 6 71 4example 3 25 7 61 4 u00b1 3 8 73 6 70 3 u00b1 3 2 82 7tolbutamide 25 7 73 3 u00b1 4 2 87 9 68 0 u00b1 4 9 80 1__________________________________________________________________________ significantly different from control p lt 0 05 p lt 0 02 p lt 0 01 p lt 0 001 table 2______________________________________effects of the compounds of example 1 and 2 on theblood sugar level in alloxan diabetic rats______________________________________compounds example 1 example 2dose p o mg kg control 25 25no of animals 6 9 7______________________________________blood initial 387 4 u00b1 24 9 414 2 u00b1 20 4 408 1 u00b1 28 0sugar relative 100 0 106 9 105 3 mg 2 hour 330 5 u00b1 25 3 308 9 u00b1 28 9 300 8 u00b1 31 5 relative 100 0 93 5 91 0 4 hour 330 0 u00b1 26.