ionic drugs for oral or systemic diseases for example peptide drugs e g calcitonin ddavp analgesics and antiinflammatory agents e g indomethacin ibuproden mouth disinfectants chlorohexidine hydrochloride hexylresorcine cardiovascular agents e g nitroglycerin isosorbide dinitrate nifedipine antiasthmatics e g disodium cromoglycate antibiotics e g penicillin erythromycin chemotherapeutics e g sulfathiazole nitrofurazone local anesthetics e g benzocaine cardiotonics e g digitalis digoxin antitussives and expectorants e g codeine phosphate isoproterenol hydrochloride agents affecting digestive organs antihistamines anti inflammatory steroids hemostatics sexual hormones sedatives antitumor agents or the like u201c mucoadhesive u201d refers to hydrophilic polymers natural or synthetic which by the hydrophilic designation can be either water soluble or swellable and which are adhesive to mucosal surfaces preferably such adhesives adhere the active substances containing formulation to the mucosal tissues as well as functioning as a reservoir of active substances which can be dissolved or absorbed via contacting the mucosal membrane u201c pvp u201d u201c polyvinylpyrrolidone u201d u201c pvp mucoadhesive u201d u201c non plasticized pvp mucoadhesive u201d and the like refers to a mucoadhesive composition consisting essentially of pvp polymer that does not contain any plasticizers polyvinylpyrrolidone is a homopolymer of 1 ethenyl 2pyrrolidinone and is available in various grades under the generic or tradename u201c povidone u201d mixtures of one or more.