mucous membrane ocular mucous membrane ear mucous membrane genital mucous membrane pharyngeal mucous membrane respiratory tract mucous membrane bronchial mucous membrane pulmonary mucous membrane gastric mucous membrane enteric mucous membrane or rectal mucous membrane that is safe useful as a prophylactic or therapeutic agent for infectious diseases or cancers and capable of effectively inducing the systemic immune response and mucosal immune response the present invention provides a mucosal vaccine composition to be administered to at least one mucous membrane selected from the group consisting of a human or animal intraoral mucous membrane ocular mucous membrane ear mucous membrane genital mucous membrane pharyngeal mucous membrane respiratory tract mucous membrane bronchial mucous membrane pulmonary mucous membrane gastric mucous membrane enteric mucous membrane and rectal mucous membrane the mucosal vaccine composition containing at least one antigen and as an adjuvant a lipopolysaccharide derived from at least one gram negative bacterium selected from the group consisting of serratia leclercia rahnella acidicaldus acidiphilium acidisphaera acidocella acidomonas asaia belnapia craurococcus gluconacetobacter gluconobacter kozakia leahibacter muricoccus neoasaia oleomonas paracraurococcus rhodopila roseococcus rubritepida saccharibacter stella swaminathania teichococcus zavarzinia pseudomonas achromobacter bacillus methanoculleus methanosarcina clostridium micrococcus flavobacterium pantoea acetobacter zymomonas xanthomonas and enterobacter or a salt thereof wherein a mass ratio between the adjuvant and the antigen is 0 002 to 500 application_number US 201414917077 A description the present invention will be described in more detail with reference to the following examples but is not limited to these examples each of the following administration groups was prepared for ten animals as an appropriate dose of a vaccine antigen to mice two patterns of 1 0 u03bcg and 0 1 u03bcg were examined in the case of an influenza vaccine if the dose is more than 1 0.