publication_number US 4435333 A abstract a method for chlorinating the carboxylic group of u03b1 aminoacids is described wherein the aminoacid is suspended in an optionally solvate forming solvent treated with an excess of gaseous hcl and then with a chlorinating agent having the general formula 2 ncho a typical compound thus obtained is the dioxane hemisolvate of d2 glycyl chloride hydrochloride application_number US 40135782 A description the present invention will now be further described with reference to some embodying examples given for illustrative and non limiting purposes preparation of the adduct socl 2 ch 3 2 ncho in a flask equipped with stirrer thermometer and the thermostatic bath 119 2 g 1 mole of thionyl chloride are charged cooled to 0 u00b0 c and 73 1 g 1 mole of n n dimethylformamide are added under stirring yet maintaining the temperature below 5 u00b0 c at the end of the addition the temperature is allowed to rise up to 20 u00b0 c and then maintained constant for at least 3 hours 192 g of a yellow oily liquid which is extremely reactive with atmospheric moisture are obtained preparation of the adduct so 2 cl 2 ch 3 2 ncho in a flask equipped with stirrer thermometer and thermostatic bath 135 g 1 mole of sulphuryl chloride are charged cooled to 0 u00b0 c and 73 1 g 1 mole of n n dimethylformamide are added under stirring yet maintaining the temperature below 5 u00b0 c at the end of the addition the temperature is allowed to rise up to 20 u00b0 c and maintained.