layer soluble in the gastric juice a drug which is incompatible with the drug within capsules film coating agents soluble in the gastric juice are known for use e g in film coating for preventing the active ingredient from being degraded due to moisture in the syrup to be used in sugar coated plain tablets five 5 parts of hpmcp 200731 hydroxypropylmethylcellulose phthalate of the japanese pharmacopeia grade was dissolved in 100 parts of a 7 3 mixed solvent composed of methylene chloride and denatured ethanol followed by addition of 1 part of glycerin fatty acid ester of the food additive grade to give a clear and slightly viscous enteric coating solution a jacketed tank in which film coating under vacuum can be performed was charged with 20 000 hard capsules each filled with 100 mg of pancreatic digestive enzyme ta product of amano pharmaceutical co ltd and the capsules within the tank were heated for 20 minutes at a jacket temperature of 50 u00b0 c under vacuum 500 torr while revolving the tank at 0 5 rpm then the vacuum was adjusted to 2 torr and the tank revolution to 20 rpm and 10 6 kg of the above mentioned enteric coating solution was sprayed using a one fluid spray gun tip orifice diameter 0 18 mm discharge pressure 20 kg cm 2 in a typical run spraying of the enteric coating solution resulted in a change of the vacuum from 2 torr to an equilibrated state at 9 12 torr it took 4 hours to complete the spraying of the enteric coating solution after spraying the capsules were dried for 20 minutes at a.