antisense orientation in order to prove for production of antisense rna such antisense rna may be used in controlling the level of the polypeptide of the present invention in a cell the present invention also provides monoclonal or polyclonal antibodies against a polypeptide of the present invention the present invention further provides a process for production of monoclonal or polyclonal antibodies to the polypeptides of the present invention monoclonal antibodies may be prepared by common hybridoma technology using polypeptides of the present invention or fragments thereof as an immunogen polyclonal antibodies may also be prepared by common means which comprises inoculating host animals for example a rat or a rabbit with polypeptides of the invention and recovering immune serum the present invention also provides pharmaceutical compositions containing a polypeptide of the present invention or an antibody thereof in association with a pharmaceutically acceptable diluent and or carrier as the polypeptide of the present invention those which have deficiency in a part of their amino acid sequence e g a polypeptide comprised of the only essential sequence for revealing a biological activity in an amino acid sequence shown in seq id no 2 those which have a part of their amino acid sequence replaced by other amino acids e g those replaced by an amino acid having a similar property and those which have other amino acids added or inserted into a part of their amino acid sequence as well as those comprising the amino acid sequence shown in seq id no 2 5 or 8 as known well there are one to six kinds of codon encoding one amino acid for example one kind of codon for methionine met.