strain and 10 mice were transplanted with low metastatic strain on the 9th day animals were euthanized and total blood plasma of both mice groups was collected after isolation the total fraction of blood plasma dna was stored at u2212 20 u00b0 c in phosphate buffer five groups of mice with transplanted llc tumor participated in the experiment 2 group 6 mice transplanted with low metastatic llc strain intravenous administration of total dna fraction from mice with transplanted highly metastatic strain 0 05 mkg of dna in 200 mkl of phosphate buffer on the 7 th and 8 th day after transplantation 3 group 6 mice transplanted with low metastatic llc strain intravenous administration of total dna fraction from mice with transplanted low metastatic strain 0 05 mkg of dna in 200 mkl of phosphate buffer on the 7 th and 8 th day after transplantation 4 group 6 mice transplanted with low metastatic llc strain intravenous administration of total dna fraction from mice with transplanted highly metastatic strain 0 05 mkg of dna in 200 mkl of phosphate buffer on the 7 th and 8 th day after transplantation intraperitoneal administration of dnase i at 1 mg kg dose two times daily at 7 th and 8 th day after transplantation number of metastatic foci in lungs was estimated on the 15 th day after transplantation n received data indicates that blood plasma dna from mice with highly metastatic llc strain intensify metastasizing of low metastatic llc strain dnase i influence on life span of c57b1 mice transplanted with llc tumor highly metastatic strain group 2 6 mice were treated with intraperitoneal administration.