90 ml was stirred for 14 hours at 25 u00b0 c after which time t l c 2 3 benzene acetone showed that all of compound vi had reacted the dark solution was poured into ether 500 ml and the resultant mixture was filtered the filtrate was evaporated at u2266 40 u00b0 c and then three 25 ml portions of toluene were added to and evaporated from the residue to remove all of the pyridine the resultant syrup was taken up in ether and the suspension filtered through a small column 250 u00d7 20 mm of silica get to remove residual silver salts the effluent was evaporated in vacuo to give the pure compound vii as a syrup yield 4 g 100 u03b1 d 23 55 2 u00b0 c 1 4 chloroform u03bd max film 3420 3290 nh 1725 ester co 1660 amide i c c 1600 1585 monosubstituted phenyl and 1525 cm 1 amide ii anal calc for c 16 h 19 no 5 305 33 c 62 94 h 6 27 n 4 56 found c 62 52 h 6 52 n 4 21 to a solution of compound vii 5 g 16 4 mmoles in absolute methanol 30 ml was added m sodium methoxide 0 5 ml and the mixture was kept for 12 hours at 25 u00b0 c at which point t l c 2 3 benzene acetone indicated that saponification was complete the solution was passed through a small bed 250 u00d7 20 mm of silica gel in.