US 65905105 A description the invention will be more clearly understood from the following description of some embodiments thereof given by way of example only with reference to the accompanying figures and graphs carbomer 974 pnf 1 g is added to approximately 80 g deionised water following complete addition of carbomer the preparation is mixed for 30 minutes phenyloin sodium 5 g is gradually added while mixing the gel thickens the gel is made up to 100 g with deionised water with mixing the ph is adjusted to 7 4 with sodium hydroxide hydroxypropyl u03b2 cyclodextrin 30 g is dissolved in approximately 60 g deionised water with stirring phenyloin sodium 1 g is added slowly to form a suspension carbomer 974 pnf 1 g is gradually added with mixing at 1500 rpm the gel is made up to 100 g with deionised water with mixing the ph is adjusted to 7 4 with sodium hydroxide a rat dorsal wound model as described by dacosta et al surgery 123 3 287 93 1998 was employed wounds were treated by insertion of aliquots 0 2 g of either the phenyloin containing gel described in example 2 above or a gel manufactured without phenyloin ten days afterwards the integrity of the wounds were examined and compared the beneficial effects of the invention were manifested by an increase in wound tensile strength of approximately 30 when compared with the inactive treatment accompanied by increased amounts of hydroxyproline which is a marker of collagen deposition a full thickness excisional wound were studied in rats rendered diabetic by the administration of streptozotocin wounds were treated by.