and removed by fluorescence guided endoscopic surgery utilizing endoscopes and surgical devices under guidance of fluorescence if it is determined that open surgery is required to remove a tumor fluorescence assisted surgery can also be conducted under these circumstances wherein the surgeons utilize headlights capable of delivery of tuned frequencies of light and other light emitting equipment may be used such as retractors probes and dissectors with built in illumination the method of this invention primarily utilizes cells which normally desquamate from the various surfaces of the body both internal and external thus their removal by non invasive means does not result in undue patient trauma these non invasive cell collection methods accelerate the release of such cells from the surfaces of the tumor mass and then as described above are collected and analyzed fig2 illustrates an organizational diagram of the types of cells which may be removed according to these non invasive and minimally invasive methods and also shows the major steps or actions which are used to collect the types of cell as shown cell collection 10 may be achieved with cells from the pulmonary system 30 prostate gland 32 cervical uterine area 34 breast 36 oral areas 38 urinary tract 40 gastrointestinal tract 42.