the manufacture process of liposomes using the device 100 of the present invention is described as follow at first the aqueous solution s 1 and the organic solution s 2 are infused into the reaction tank 1 due to insolubility property between the organic and aqueous phase two solutions contact each other and thus form an interface between the filter unit 21 and the collector 11 once being infused into the reaction tank 1 the bioactive agent containing aqueous solution s 3 is filtered by the filter unit 21 firstly and is then sequentially passed through the organic solution s 2 and the aqueous 39 solution s 1 finally w o w double emulsion l is formed and enters into the collector 11 to be harvested with reference to fig3 this is a flow chart of the device according to the second embodiment of the present invention this embodiment is based on double emulsion method and uses the device 100 mentioned above as shown in fig2 accordingly the manufacture process of liposomes is simple and programmable and particularly has high encapsulation efficiency step 101 providing an aqueous solution s 1 an organic solution s 2 and a bioactive agent containing aqueous solution s 3 the details of the process are described as follow 1 the organic solution s 2 according to this embodiment is consisting of an organic solvent and at least one phospholipid the organic solvent used here is chloroform and the phospholipid includes.