to practice the methods of the invention a kit is provided for the detection and measurement of elements in a sample where the measured elements include an element tag attached to a nonphosphorylated substrate and a metal ion coordination complex comprising an element tag for directly tagging non phosphorylated substrate non phosphorylated substrate a solid support metal ion coordination complex and optionally kinase kinase buffer and atp the kit can further comprise instructions for i directly tagging the nonphosphorylated substrate with an element tag ii incubating kinase with element labeled non phosphorylated substrate in kinase buffer iii attaching metal ion coordination complex to the support iv addition of said mixture to support with attached metal ion coordination complex vi separating bound substrate from unbound substrate vii eluting the bound substrate and viii detecting and measuring the bound substrate by elemental analysis the kit can further comprise a non phosphorylated substrate wherein the non phosphorylated substrate is directly labeled with an element tag the kit can further comprise a multitude of non phosphorylated substrates directly labeled with unique element tags the support with attached metal ion coordination complex can be a titanium oxide bead the kit can further comprise a support with an attached metal ion coordination complex also provided is a kit for the detection and measurement of elements in a sample where the measured elements include element labels of uniquely labeled beads and an element of a metal ion coordination complex comprising a multitude of non phosphorylated substrates uniquely labeled beads metal ion coordination complex and optionally kinase buffer and atp the kit can further comprise instructions for i immobilizing the non phosphorylated substrates on element labeled beads in separate solutions ii incubating.