mixtures thereof in conventional manner for example in the case of diasteroisomeric isomers chromatographic separation may be employed the iupac names of the compounds mentioned in the examples were generated with acd version 8 unless specified otherwise in the examples characterization of the compounds is performed according to the following methods nmr spectra are recorded on 300 or 600 mhz varian and acquired at room temperature chemical shifts are given in ppm referenced either to internal trimethylsilyl or to the residual solvent signal all the reagents solvents catalysts for which the synthesis is not described are purchased from chemical vendors such as sigma aldrich fluka bio blocks ryan scientific syn chem chem impex aces pharma however some known intermediates for which the cas registry number cas are mentioned were prepared in house following known procedures usually the compounds of the invention were purified by flash column chromatography using a gradient solvent system of methanol dichloromethane unless otherwise reported those skilled in the art will be able to routinely modify and or adapt the following schemes to synthesize any compound of the invention covered by formula i some compounds of this invention can generally be prepared in one step from commercially available literature starting materials to the suspension of potassium carbonate 2 16 g 15 7 mmol in thf at room temperature was added imidazole 4 27 g 62 8 mmol the mixture was stirred at room temperature for 10 minutes then 4 bromomethyl 2 methylbenzonitrile cas 1001055 64 6 6 6 g 31 4 mmol was added and refluxed for 24 hours the mixture was then cooled to room temperature potassium carbonate was filtered off the filtrate.