and a condenser was charged with 3 dimethylamino 1 pyridin 3 yl propenone 10 grams 0 0567 mole followed by addition of methanesulfonic acid 1 2 ml 0 0165 mole the mixture was heated at 145 150 u00b0 c under vigorous stirring for 4 5 hours then the reaction mixture was cooled to 90 u00b0 c and 1 propanol 70 ml was added the mixture was stirred at 80 u00b0 c for 1 hour and then cooled to 15 u00b0 c a precipitate was collected by filtration and dissolved in water 150 ml while heating to 80 u00b0 c the mixture was cooled gradually to 20 u00b0 c for 2 hours and a precipitate was collected by filtration washed with cold water 2 u00d7 20 ml and dried at 85 u00b0 c overnight to give 37 76 g of 2 oxo 4 3 pyidyl pyrimidine in 60 yield having a purity of 99 4 in a 250 ml two necked flask equipped with a mechanical stirrer and a condenser a mixture of 2 oxo 4 3 pyidyl pyrimidine 3 g 0 017 mol and pocl 3 18 ml was stirred at 50 u00b0 c for 4 5 hrs the reaction mixture was poured into cold water 50 ml and neutralized with 47 aqueous naoh solution to ph 8 the solution was.