dialkylsquarate employed preferably about 0 7 equivalent of the benzamide salt is employed in some embodiments it is preferred to mediate the coupling reaction with an organic base for example but not limited to pyridine pyridine derivatives and tertiary amines for example but not limited to triethyl amine preferably the base is a tertiary amine more preferably it is selected from diisopropylethylamine and triethyl amine more preferably the base is triethylamine when used it is preferred to employ at least about one equivalents of the base in comparison with the amount of benzamide salt employed preferably about 1 8 equivalents in some embodiments using triethylamine to mediate the coupling reaction it is preferred to add the triethylamine over a period of the reaction time preferably about two thirds of the reaction period while maintaining the reaction mixture temperature from about u2212 5 u00b0 c to about 5 u00b0 c in some embodiments utilizing triethylamine it is preferred to work up the reaction after the reaction period by seeding the reaction mixture with the solid amounts of the compound of formula 2c to nucleate crystal growth then add acetic acid to insure that any base still present is neutralized thus maximizing yields of the coupled product when used it is preferable to add an amount of acetic acid equivalent to twice the mole amount of triethylamine added in some embodiments employing acetic acid following acid addition it is preferred to heat the reaction mixture preferably to at least 60 u00b0 c more preferably to a temperature of from about 60 u00b0 c to about 70 u00b0 c then reduce the temperature in controlled stages preferably first to a temperature of less than about 35 u00b0 c more preferably to a temperature of from.