18 0 013 19 0 008______________________________________ the compounds were also evaluated in an in vivo screen designated apcc whereby male sprague dawley rats 200 to 225 g were randomly divided into treatment groups and dosed at 4 pm with either vehicle cmc tween or suspensions of compounds in vehicle the normal chow diet was then replaced with the pcc diet with either 1 or 0 5 cholic acid the rats consumed this diet ad libitum during the night and were sacrificed at 8 am to obtain blood samples for cholesterol analysis using standard procedures statistical differences between mean cholesterol values for the same vehicle were determined using analysis of variance followed by fisher s least significant test the data appear in table ii where they are expressed as change table ii______________________________________ apccexample change tc______________________________________ 1 61 2 3 63 4 37 5 49 6 58 7 67 8 71 9 2010 5611 6712 2613 2614 2515 7216 3717 5918 5119 43______________________________________ as indicated above and shown by the data presented below the compounds of the present invention have been found to be characterized as nontoxic in in vivo studies the nontoxic nature of the compounds of the present invention is particularly advantageous and surprising in light of toxicity screens of previously disclosed amide ester acat inhibitors but which are not substituted.