tubing or include portions of both the tubing string 112 carries the seal 122 and includes at least two valves 125 126 bracketing the packer seal e g valve 125 provided on one side of seal 122 and valve 126 provided on the other side of seal valves 125 126 provide and control fluid communication between a well bore annulus 128 and an interior region 130 of the tubing string 112 when open valves 125 126 allow communication of fluid between the annulus 128 and tubing string interior 130 and when closed valves 125 126 substantially block communication of fluid between the annulus 128 and tubing string interior 130 in this embodiment the valves 125 126 are electrically operated valves controlled from the surface 116 in other embodiments valves 125 126 can include other types of closure mechanisms e g apertures in the tubing string 112 opened closed by sliding sleeves and other types of closure mechanisms additionally in other embodiments the valves 125 126 can be controlled in a number of other different manners e g as check valves thermostatically mechanically via linkage or manipulation of the string 112 hydraulically and or in another manner the downhole fluid lift system 118 is operable to lift fluids towards the ground surface 116 in the illustrated embodiment the downhole fluid lift system is an electric submersible pump 118 mounted on the tubing string 112 the electric submersible pump 118 has a pump inlet 132 which draws fluids from the well bore annulus 128 uphole of the packer seal 120 and a pump outlet 134 which discharges fluids into the interior region 130 of the tubing string 112 power and control lines associated with electric submersible pump 118 can be attached to an exterior surface of tubing string 112 communicated through.