with nbs in thf to provide bromoether 16 which is reacted with dbu in hot toluene to give enol ether 17 acid hydrolysis of 17 using p toluenesulfonic acid monohydrate in hot thf water yields ketotriol 18 which is saponified with lioh in meoh water to afford 6 the 6 keto pgf 1 u03b1 analogs of the present invention may be contained in various types of pharmaceutical compositions in accordance with formulation techniques known to those skilled in the art in general these compounds will be formulated in solutions for topical ophthalmic administration solutions suspensions and other dosage forms are particularly preferred for the treatment of dry eye the ophthalmic compositions of the present invention will include one or more compounds of the present invention in a pharmaceutically acceptable vehicle various types of vehicles may be used aqueous solutions are generally preferred based on ease of formulation biological compatibility as well as a patient 39 s ability to easily administer such compositions by means of instilling one to two drops of the solutions in the affected eyes however the compounds of the present invention may also be readily incorporated into other types of compositions such as suspensions viscous or semi viscous gels or other types of solid or semi solid compositions suspensions may be preferred for those compounds of the present.