4 925 673 and 3 625 214 and jein tips 19 155 157 1998 the contents of which are hereby incorporated by reference in one embodiment the o acylated heparin can be formulated into a liposome or microparticle which is suitably sized to lodge in capillary beds following intravenous administration when the liposome or microparticle is lodged in the capillary beds surrounding ischemic tissue the agents can be administered locally to the site at which they can be most effective suitable liposomes for targeting ischemic tissue are generally less than about 200 nanometers and are also typically unilamellar vesicles as disclosed for example in u s pat no 5 593 688 to baldeschweiler entitled u201c liposomal targeting of ischemic tissue u201d the contents of which are hereby incorporated by reference preferred microparticles are those prepared from biodegradable polymers such as polyglycolide polylactide and copolymers thereof those of skill in the art can readily determine an appropriate carrier system depending on various factors including the desired rate of drug release and the desired dosage in one embodiment the formulations are administered via catheter directly to the inside of blood vessels the administration can occur for example through holes in the catheter in those embodiments wherein the active compounds have a relatively long half life on the order of 1 day to a week or more the formulations can be included in biodegradable polymeric hydrogels such as those disclosed in u s pat no.