to the solution at 40 u00b0 c cooling to 5 u00b0 c filtration and washing with heptane 15 l led to isolation of 1 2 amino 4 chloro phenyl 2 chloro ethanone ma 2 5 kg 12 mol 29 yield 99 2 a a hplc to a solution of acetamido diethyl malonate 5 87 kg 27 0 mol 1 01 equiv in ethanol 31 5 l was added 21 sodium ethoxide in ethanol 12 1 l 32 4 mol 1 21 equiv at 22 u00b0 c a mixture of 1 2 amino 4 chloro phenyl 2 chloro ethanone ma 5 44 kg 26 7 mol sodium iodide 0 60 kg 4 0 mol 0 15 equiv ethanol 17 l and tetrahydrofuran thf 17 l was dosed into the reactor at 40 u00b0 c and stirring was continued for 2 h at 45 u00b0 c water 36 l was added after evaporation of the reaction mixture to 45 of the original volume and the aqueous phase was extracted twice with dichloromethane 34 5 l 20 l the combined organic phases were washed with water 14 l after removal of 25 of the original volume by distillation under reduced pressure isopropanol 32 l was added and 50 thereof distilled off at 60 u00b0 c heptane 11 l was added cooling the mixture to 5 u00b0 c filtration and washing with isopropanol heptane 1 1 15 l afforded 2 acetylamino 2 2 2 amino 4 chloro phenyl 2 oxo ethyl malonic acid diethyl ester iva 5 86 kg 15 2 mol 57 yield 99 5.