hedgehog family of proteins including indian sonic and desert hedgehog admp 1 members of the interleukin il family including il 1 thru il 6 gdf 5 and members of the colony stimulating factor csf family including csf 1 g csf and gm csf and isoforms thereof in addition bone producing cells such as mesenchymal stem cells mscs can be delivered with the hardenable compositions by first encapsulating the cells in hydrogel spheres then mixing in mscs provide a special advantage because it is believed that they can more readily survive relatively harsh environments that they have a desirable level of plasticity and that they have the ability to proliferate and differentiate into the desired cells in some embodiments the mesenchymal stem cells are obtained from bone marrow preferably autologous bone marrow in others the mesenchymal stem cells are obtained from adipose tissue preferably autologous adipose tissue in some embodiments the mesenchymal stem cells used in an unconcentrated form in others they are provided in a concentrated form when provided in concentrated form they can be uncultured uncultured concentrated mscs can be readily obtained by centrifugation filtration or immuno absorption when filtration is selected the methods disclosed in u s pat no 6 049 026 u201c muschler u201d the specification of which is incorporated by reference in its entirety are preferably used in some embodiments the matrix used to.