11 4 11 25 example 4 0 1 6 7 7 7 8 5 example 11 0 1 6 9 7 7 9 4 example 12 0 1 3 8 4 7 6 9 ______________________________________ p lt 0 01 student 39 s paired t test table 6__________________________________________________________________________the effect of compounds of formula iii and u 46619 9 11 dideoxy 9 u03b1 11 u03b1 methanoepoxy prostaglandin f sub 2 u03b1 on monkeyintraocular pressure __________________________________________________________________________ intraocular pressure changes at predeterminedformula time hr after dosingiii dose 0 2 4 6 24 26 28 30 48 50 52__________________________________________________________________________u 46619 0 2 0 0 3 1 0 example 7 0 01 0 0 4 0 0 1 0 3 2 4 6 3 2 1 8 3 8 4 0 __________________________________________________________________________ intraocular pressure changes at predetermined formula times hr after dosing iii dose 54 72 74 76 78 96 98 100__________________________________________________________________________ u 46619 example 7 0 01 4 2 4 2 2 0 3 2 4 0 2 0 2 2 3 2__________________________________________________________________________ p lt 0 05 students 39 paired t test p lt 0 01 the foregoing description details specific methods and compositions that can be employed to practice the present invention and represents the best mode contemplated however it is apparent from one of ordinary skill in the art that further compounds with the desired pharmacological properties can be prepared in an analogous manner and that the disclosed compounds can also.