affording 1 7 grams 69 of the title compound as a white solid lrms 219 1 m 1 a solution of 4 chloropyrrolo 2 3 d pyrimidine 2 4 grams 15 9 mmol prepared by the method of davoll j am chem soc 82 131 1960 which is incorporated by reference in its entirety and the product from method a 1 7 grams 7 95 mmol dissolved in 2 equivalents of triethylamine was heated in a sealed tube at 100 u00b0 c for 3 days following cooling to room temperature and concentration under reduced pressure the residue was purified by flash chromatography silica 3 methanol in dichloromethane affording 1 3 grams 50 of the title compound as a colorless oil lrms 336 1 m 1 to the product from method b 0 7 grams 2 19 mmol dissolved in 15 ml of ethanol was added 1 5 ml of 2 n hydrochloric acid and the reaction mixture degassed by nitrogen purge to the reaction mixture was then added 0 5 grams of 20 palladium hydroxide on carbon 50 water aldrich and the resulting mixture shaken parr shaker under a 50 psi atmosphere of hydrogen at room temperature for 2 days the celite filtered reaction mixture was concentrated to dryness in vacuo and the residue purified by flash chromatography silica 5 methanol in dichoromethane affording 0 48 grams 90 of the title compound lrms 246 1 m 1 to a stirred solution of the product from method c 0 03 grams 0 114 mmol.