undertaken immediately after conventional surgery or course of radiation to serve an adjuvant role certain of the examples also demonstrate that favorable results can be achieved when the treatment of this invention is carried out before any conventional mode of treatment has been adopted of course conventional radiation or administration of an anti hormone medication can be added at any time with a reasonable expectation of increasing the attrition of the tumor a 63 year old man consulted his physician is december 1993 complaining of mild obstruction of urine flow a prostate specific antigen test was carried out with a result of 15 and a sonogram revealed enlargement of three lymph nodes treatment was initiated with flutamide plus leuprolide according to the usual protocol and follow up readings of psa showed a drop to zero periodic measurement of psa were made and after four years a substantial increase was observed over a six month period a bone scan was conducted and showed the presence of tumor in the lower vertebrae and several ribs it was concluded that the tumor had become resistant to drug therapy and treatment with flutamide plus leuprolide discontinued instead a course of radiation of the involved ribs and lumbar sacral vertebrae was carried out to reduce pain following which the patient was referred for further treatment he was started on naltrexone.