galvanic skin response transcutaneous p0 2 heart rate variability transcranial doppler etc could be used as well for closed loop goal directed and therapeutic endpoints additional endpoints such as the electroencephalogram eeg somatosensory evoked potential sep auditory evoked potentials and other indicators of neural activity and consciousness including those associated with sleep and attentiveness such as actigraphy breathing rate eye movement and others could be used to drive temperature management to enhance sleep and optimize circadian physiology of the brain and body these parameters have been well correlated with neurologic activity ranging from seizures to brain injury to consciousness eeg sep auditory evoked potentials and stages of sleep eeg breathing rate eye movements actigraphy allowing for temperature to be used to optimize ranges of neurologic activity such as sleep seizure suppression and others the controller also receives and sends information to and from devices capable of changing hemodynamics these include but are not limited to intravenous infusion systems which may provide intravenous fluids and medications capable of improving or optimizing the patient 39 s hemodynamic and tissue perfusion status the controller is thus operably linked directly or indirectly to other components of the system e g the various devices described herein and is capable of receiving information and data controller input usually in the form of e g measurements from those devices for example the controller is configured to receive data that includes the actual values of physiological parameters of a patient in addition the controller is configured to receive input from an operator e g a physician or health care professional such as individual characteristics of a.