in the following section preferred embodiments are described by way of examples to illustrate the process of the invention however these are not intended in any way to limit the scope of the present invention variants of these examples would be evident to persons ordinarily skilled in the art x ray diffraction xrd patterns were taken with a diffractometer manufactured by rigaku corporation specifically the model ru h3r the goniometer was a cn2155a3 and the x ray tube was equipped with cu target anode the settings for the divergence slits were 1 0 for the receiving slit 0 15 mm and for the scatter slit 1 0 the operating power was 40 kv 100 ma the scanning speed was 2 deg min step 0 02 deg and the wavelength was 1 5406 a infrared spectra were taken with a perkin elmer 16 pc with scan parameters of 16 scans 4 0 cm u2212 1 according to the usp 25 general test methods page 1920 infrared absorption spectra were obtained by the potassium bromide pellet method differential scanning calorimetry was done by the model dsc821 e manufactured by mettler toledo with sample weights of 3 5 mg and the sample temperature range of 25 100 u00b0 c heating rate of 1 u00b0 c min nitrogen flow of 80 0 ml min with one hole in the crucible s omeprazole free base 5 g was added to methanol 25 ml and stirred at 25 30 u00b0 c barium hydroxide 4 6 g dissolved in methanol 40 ml was slowly added to the above solution in 10 minutes at 25 30 u00b0 c the reaction.