the optical path switchover section 11 are transparent furthermore it is possible to change the transmitted image into a differential inference image a phase difference image etc and a change can be made depending on the purpose in that case as is known an optical element such as a polarizing plate has to be additionally disposed in position measured image data are stored in a control unit 17 including a memory and a cpu and an image synthesis or the like is performed and displayed on a monitor 18 from the image obtained a plurality of concerned areas is picked out on the basis of parameter conditions set by the operator and their area numbers and positions are recorded then if the neighborhood of their areas is measured again at a higher resolution and high resolution transmitted light images are recorded more detailed analysis will be possible the reaction reagent containing a marker probe is dropped onto only selected concerned areas to subject these areas to hybridization immune staining etc locally these treatments are carried out by a micro reaction mechanism 19 the micro reaction mechanism 19 is disposed above the specimen when a reaction is operated the transmission illumination light source 7 and the condenser lens 8 shift sideways and the micro reaction mechanism 19 moves to immediately above the specimen the micro reaction mechanism 19 is configured as shown in fig2 and 3 fig2 is a configuration diagram of a reagent solution dispensing mechanism which includes a micro nozzle unit 100 to dispense reagent solutions such as a marker probe solution.