ml of a first solution containing 3 of the monosaccharide derivative having an end group of carboxyl adjusting a ph of the first solution to 5 6 with 0 1m hcl adding the first solution into 50 ml of a second solution containing 4 of chitosan grafted with polyvinyl alcohol and 40 of methanol adding 0 3 g of a catalyst b of dmap 30 u00b0 c stirring in speed of 80 r min for 30 hours condensing by evaporation under 60 u00b0 c reducing a volume thereof to 10 ml finally depositing with 150 ml of absolute alcohol processing vacuum filtrating and processing vacuum drying to obtain a product wherein a yield thereof is 58 weight of product weight of chitosan derivative 100 suspending 2 g of glucosamine hydrochloride in 40 ml of methanol adding 4 g of sodium methoxide 24 u00b0 c protecting with argon stirring in speed of 30 r min for 2 hours adding 0 93 g of succinic anhydride and 4 ml of a catalyst a of triethylamine in turn 24 u00b0 c stirring in speed of 30 r min for 48 hours adding 0 1m hcl until ph 6 ending reaction drying by distillation under 60 u00b0 c recrystallizing with absolute alcohol and processing vacuum drying to obtain a monosaccharide derivative having an end group of carboxyl wherein.