and each of r c and r d independently is h alkyl aryl heteroaryl cyclyl heterocyclyl or alkylcarbonyl application_number US 65667103 A description the compounds described above can be prepared by methods well known in the art as well as by the synthetic routes disclosed herein for example a pyrimidine compound e g compounds 1 27 can be prepared by using 2 4 6 trichloro pyrimidine as a starting material the three chloro groups can be displaced by various substitutes more specifically first chloro group e g at position 6 can react with e g morpholine to form a morpholinyl pyrimidine 2 aryl and 2 alkylpyrimidinde dichloro compounds can also be prepared by reacting an amidine with a malonic ester followed by treatment with phosphorous oxychloride second chloro group can be replaced by reacting with a nucleophile such as an alcohol in the presence of base e g sodium hydride in other examples a compound of formula i wherein y is ch 2 e g compound 1 can be prepared by reacting the pyrimidine chloride with a grignard reagent an organotin reagent an organocopper reagent an organoboric acid or an organozinc reagent in the presence of an organopalladium compound as a catalyst isomeric forms may be produced the desired isomeric product can be separated from others by e g high performance liquid chromatography third chloro group undergoes a displacement reaction with e g hydrazine and the primary amine of.