seen more fully by the example given below ciglitazone was tested in the zucker rat a well known model of insulin resistant mammals and was shown to lower blood pressure as described below two groups of 6 week old obese female zucker fa fa rats 10 control and 10 experimental were fed a diet containing 65 carbohydrate 18 protein 5 fat 5 fiber 0 1 sodium chloride nacl with the remainder containing water vitamins and minerals the experimental group received the drug ciglitazone powder as a 0 05 w w dietary admixture 33 to 58 mg kg body weight day calculated from food intake for 30 days the control group did not receive the drug the mean arterial pressure map was measured in the unanesthetized unrestrained state by indwelling femoral artery catheters attached to a pressure transducer and blood drawn for measurement of blood glucose and plasma insulin concentrations the results of the study are set forth in table 1 the effect of insulin sensitizing compounds in primates was shown as follows obese insulin resistant rhesus monkeys were given pioglitazone 1 mg kg day oral gavage for two weeks glucose tolerance was substantially improved in 5 of 6 monkeys systolic blood pressure was reduced an average of 16 mmh mean arterial blood pressure map was reduced an average of 8 4 mmhg these data show that improved insulin sensitivity produced by drugs of this type are an effective treatment for lowering blood pressure table 1______________________________________effects of ciglitazone on mean arterial pressure map and urine outputmeasurement control ciglitazone significance sup 1______________________________________map mm hg 119 u00b1 2 n 9 112 u00b1 4 n 6 p lt 0 05 sup 2urine output 80 u00b1 5 n 9 97 u00b1 8 n 6 p lt 0 05 sup 3insulin mu ml 171.