to phenylmethyl 1 39 3 3 4 dichlorophenyl 5 3 5 dichlorophenyl methoxy 4 oxopentyl 1 2 dihydro spiro 3h indole 3 4 39 piperidine 1 carboxylate 0 250 g 0 34 mmoles dissolved in glacial acetic acid 2 0 ml stir the solution at room temperature for 4 h then add et 2 o 30 ml decant the liquid and wash the resultant solid with et 2 o suspend the solid in water 10 ml and add 1 0m aqueous koh 5 0 ml extract the mixture with et 2 o 3 u00d7 30 ml combine the extracts wash with water and dry na 2 so 4 remove the solvent and purify the reaction mixture by preparative thin layer chromatography sio 2 eluting the plates twice with etoac hexanes ch 3 oh nh 3 15 85 3 extract the desired product with 5 ch 3 oh nh 3 etoac yield 57 mg mass spectrum fab 591 35 cl 37 cl isotope 593 m h 35 cl 37 cl isotope 595 35 cl 37 cl isotope use the method described in procedure a to prepare the title compound hrms fab m h calc 39 d for c 34 h 35 n 3 o 4 scl 2 f 6 765 1630 found 765 1610 use the method described in procedure a to prepare the title compound hrms fab m h calc 39 d for c 39 h 40 n 3 o 4 cl 4 754 1773 found 754 1757 use the method described in procedure a to prepare the title compound hrms fab m h calc 39 d for c 38 h 38 n 3 o 4 cl 4 740 1616 found 740 1625 cool a solution of.