publication_number US 4593038 A abstract a cosmetic composition is provided which comprises 3 phenylacetylamino 2 6 piperidinedione dispersed in a cosmetically suitable vehicle this cosmetic composition is useful in the topical cosmetic treatment of skin areas affected with wrinkles or hyperpigmentation application_number US 71952285 A description the invention is described below in terms of preferred embodiments known at the time of this application these embodiments represent the best mode contemplated for preparing the cosmetic compositions and their method of use the particular amino acid derivative used in the present compositions 3 phenylacetylamino 2 6 piperidinedione may be extracted from natural body fluids or be prepared synthetically by combining the amino acid l glutamine and phenylacetyl chloride for cosmetic use the compound ingredient is preferably prepared synthetically as described in prior u s pat no 4 470 970 herein incorporated by reference the amino acid derivative ingredient is then blended into a proper cosmetic vehicle to produce a semi solid dispersion the vehicle can be selected from any of cocoa butter lanolin eucerin petrolatum or a mixture of wool wax alcohols with aliphatic hydrocarbons other suitable bases will be obvious to persons skilled in the art a suitable preservative may also be included in the compositions methylparaben or propylparaben is preferred for this purpose or paraaminobenzoic acid the concentration of 3 phenylacetylamino 2 6 piperidinedione blended in the vehicle usually ranges from one to ten percent by weight the following is a particularly preferred formulation of the composition of the present invention ______________________________________ingredient amount______________________________________1 lanolin 10 0 gm2 olive oil 20 0 gm3 eucerin 10 0 gm4 cholesteryl oleate 1 5 gm5 cocoa butter 4 5 gm6 lecithin 2 0 gm7 glycol ethylglycol 8 0 gm8 honey 1 0 gm9 lemon juice.