of healing however rats treated with compound xvii or compound xx exhibited significantly greater healing p lt 0 05 compared to diclofenac and naproxen respectively treatment with the hydrogen sulfide releasing moiety of these two compounds tbz did not significantly affect the healing of gastric ulcers as compared to the vehicle treated group nsaids including those exhibiting selectivity for cox 2 may exacerbate pre existing hypertension and interfere with the effectiveness of some anti hypertensive medications whelton a nephrotoxicity of nonsteroidal anti inflammatory drugs physiologic foundations and clinical implications am j med 1999 106 5b 13s 24s to determine the effects of two compounds of the present invention compound ii and compound xx as compared to diclofenac and naproxen respectively on blood pressure rats given these drugs intraperitoneally after first inducing hypertension the rats were provided with drinking water supplemented with n u03c9 nitro l arginine methylester 400 mg l for 7 days prior to the experiment as described previously by ribeiro et al chronic inhibition of nitric oxide synthesis a new model or arterial hypertension hypertension 1992 20 298 303 the rats 5 to 8 per group were anesthetized with halothane and a carotid artery was cannulated for measurement of blood pressure which was recorded continuously on a chart recorder after measuring a stable blood pressure for at least 15 minutes one of the drugs naproxen diclofenac.