protease inhibitors concentration dependently suppressed hiv 1 production in the presence of entinostat of 0 5 u03bcm however they did not affect the cell death inducing effect specific for hiv 1 infected cells due to entinostat from these results it was probable that the combined use of entinostat and an hiv 1 protease inhibitor had the possibility of completely curing hiv 1 infection by decreasing the number of hiv 1 infected cells while suppressing secondary infection due to hiv 1 production activation by entinostat in example 2 it was confirmed that the combined use of an hiv 1 protease inhibitor and an hdac inhibitor after pretreatment with the hiv 1 protease inhibitor was capable of inducing cell death in infected cells while suppressing hiv 1 production in this example using nelfinavir nfv or darunavir drv as an hiv 1 protease inhibitor a combination experiment with entinostat was conducted according to the experimental procedure shown in fig5 for whether only the simultaneous administration of an hiv 1 protease inhibitor and an hdac inhibitor provided the same effect healthy donor derived peripheral blood mononuclear cells were infected with hiv 1 strain iii b in vitro to prepare an hiv 1 chronically infected cell model derived from human peripheral blood mononuclear cells and a combination effect of an hiv 1 protease inhibitor nfv or drv and an hdac inhibitor entinostat was examined after hiv 1 infection or pseudo infection mock infection culture was performed for 11 days and for 3 days from day 12 the.