compounds of formula i therefore are expected to act as inhibitors of the mammalian 5 lipoxygenase enzyme system of the arachidonic acid cascade this inhibition of the mammalian biosynthesis of leukotrienes indicates that the compositions would be useful to treat prevent or ameliorate in mammals and especially in humans 1 pulmonary conditions including diseases such as asthma 2 allergies and allergic reactions such as allergic rhinitis contact dermatitis allergic conjunctivitis and the like 3 inflammation such as arthritides 4 pain 5 skin conditions such as psoriasis and the like and 5 cardiovascular conditions such as angina and the like representative compounds of formula i have been tested using the following assay to determine their mammalian leukotriene biosynthesis inhibiting activity and other relevant activities cxbg cells grown intraperitoneally in cb 4 b 6 f 1 j mice were washed 5 times in dulbeccos phosphate buffered saline without calcium or magnesium suspended in medium 199 gibco at 2 u00d7 10 6 cells ml and incubated 15 minutes at 37 u00b0 inhibitor solutions in methanol were incubated with the cells 10 u03bcl 600 u03bcl cells for 5 minutes at 37 u00b0 and the cells were stimulated with 60 u03bcl a23187 50 u03bcg ml for 10.