alternatively a pharmaceutical composition may be administered to a patient which comprises at least one nonsteroidal anti inflammatory drug as the active ingredient together with at least one pharmaceutically acceptable additive the pharmaceutical composition can be prepared by a method well known to those skilled in the art examples of the pharmaceutical compositions suitable for oral administrations include for example tablets capsules powders subtilized granules granules liquids syrups and the like examples of the pharmaceutical compositions suitable for parenteral administrations include for example injections suppositories inhalants eye drops nasal drops ointments creams patches and the like the aforementioned pharmaceutical compositions may be prepared by the addition of pharmaceutically acceptable additives to the active ingredient examples of pharmaceutically acceptable additives include for example excipients disintegrators and disintegrating aids binders lubricants coating agents colorants diluents base materials dissolving agents and dissolving aids isotonic agents ph modifiers stabilizers propellants adhesives and the like a dose of the medicaments of the present invention is not particularly limited and the dose can suitably be selected depending on conditions such as for example route of administration the age and body weight of a patient symptoms a purpose of preventive or therapeutic treatment and the like for example for oral administrations the medicament of the present invention may be administered in a dose of from 0 1 to 1 000 mg per day preferably 1 mg to 100 mg for an adult the medicament of the present invention may be administered once or several times a day and preferably the medicament may be administered once before sleeping for example when loxoprofen is administered as the medicament of the present invention a dose of 60 mg per day is.