0 6placebo 58 0 u00b1 2 3u 27 182 17 0 u00b1 3 5 lt 0 001placebo 51 5 u00b1 7 1u 27 182 22 u00d7 10 mg 14 8 u00b1 1 9 lt 0 001______________________________________ standard error of the mean inhibition of collagen induced aggregation of human rat and rabbit platelets by 3 fluoro 4 phenylhydratropic acid human blood 1 part 3 8 citrate to 9 parts blood was obtained from volunteers via a vein in the forearm rat blood 1 part 2 2 citrate to 9 parts blood was obtained from anesthetized cyclopal animals via the abdominal acrta rabbits were anesthetized with pentobarbital and a carotid artery cannulated after the animal had recovered from anesthesia 10 ml of blood 1 part 3 8 citrate to 9 parts blood was drawn they were then orally dosed with 3 fluoro 4 phenylhydratropic acid or saline and a second sample was drawn 1 5 hrs later all platelet counts were made with a coulter counter model b coulter electronics hialeah fla rat platelet count was adjusted to 500 000 mm rabbit platelet counts were equalized with platelet poor plasma ppp from corresponding blood samples aggregation was measured as previously described in example 1 with a collagen sigma st louis mo suspension as the aggregating stimulus table ii__________________________________________________________________________inhibitory effects of 3 fluoro 4 phenyl hydratropic acid u 27 182 on collagen induced platelet aggregation in prp from man rat and rabbitsin vitro human rat rabbit extent of extent of extent of aggregation inhibition aggregation inhibition aggregation inhibition__________________________________________________________________________control 44 55 30 5u 27 182 0 05 44 0 34 38 2 28 0 8 2 0 25 42 4 5 14 74 5 25 0 14.