coatings such as ion attracting types of coatings are also contemplated as pre coating compositions at the point of care a biological therapeutic agent which accelerates or stimulates the natural healing process and the production of endothelial cells may be added examples of biologics for accelerating the formation or collection of endothelial cells include an antibody specific to the antigen cells that are in the blood which captures the patients circulating endothelial progenitor cells in order to accelerate the natural healing process this antibody is available from bioinvent international ab of lund sweden and has been developed for cardiovascular stents by orbus medical technology of fort lauderdale fla a second example of a biologic which can be attached to the heart valve at the point of care using the previous described peptide linker technology is the vegf receptor kdr flk 1 which is rate limiting for a fast regeneration of the endothelium resulting in an acceleration of the natural healing process in this example of a point of care applied biologic the invention device described for applying a coating and therapeutic agent at the point of care is not needed as the biologic can be attached to the peptide linker at the point of care by means such as.