capacity due to the presence of fibronectine the human fibrin glue can be injected either periurethrally or interurethrally in order to increase the urethral pressure and compensate sphincter weakness the interurethral injections are preferred because they are practically painless the injection of human fibrin glue into the submucosal tissues of the urethra or of the bladder neck creates the desired increased tissue bulk and the consequent restoration of the urethral resistance to the involuntary loss of urine experimentation was carried out on an outpatient basis in all cases interurethrally without local anaesthesia and under direct cytoscopic vision human fibrin glue was injected in 20 females into the urethral muscolar layer at the 6 o 39 clock position from just below the bladder neck to 1 2 cm distally in the urethra in 3 male patients the human fibrin glue was injected immediately over the membranous urethra at 3 6 9 and 12 o 39 clock positions the human fibrin glue used in this experimentation is marketed by the austrian company immuno gmbh under the trademark 34 tissucol 34 in all cases the treatment was interrupted when a good occlusion of the urethral lumen was obtained in many cases a good occlusion of the urethral lumen was obtained after the first injection in some cases.