present invention depends on utilizing the ugi 39 s 4 components condensation reaction of mentioned 3 1 reaction and heck reaction of reaction 3 6 as the key process first of all in the ugi 39 s 4 components condensation reaction of 3 1 no condensation reagents is required for the generation of amide bond the compound 3 1 make it possible to progress easily the formation of c ring of reaction 3 3 the ring forming reaction of reaction of 3 6 is not only the stereo chemistry of c 3 site controlled perfectly but also can proceed the reaction using catalytic amount of pd 2 dba 3 which is an expensive reagent by catalytic amount c the third feature of the present invention is that the amine represented by general formula 4 and the carboxylic acid represented by general formula 5 can be provided by a large scale production d the fourth feature of the present invention is the ring forming reaction of 10 members ring shown by reaction 5 3 process caused by bonding of sulfur atom at c 4 site the compound of the present invention to the c 4 site of which a hydroxyl group is introduced is possible to generate a cation of benzyl site easily under the acidic condition therefore the ring formation of 10 members ring by catching of sulfur atom to said cation is proceeded by high yield.