the invention were purified by flash column chromatography to a solution of s 3 1 1h imidazol 4 yl ethyl 2 methylphenyl methanol 1 34 g 6 2 mmol in dmf 8 ml and thf 50 ml were added tea 3 5 ml 24 8 mmol dmap 780mg 6 2mmol and iso butyryl chloride 2 18g 20 5mmol the resulting mixture was stirred at rt for 16 h quenched with h 2 o and extracted with ethyl acetate the combined organic layers were washed with brine and dried over na 2 so 4 and concentrated under reduced pressure the residue was purified by mplc 0 to 40 ethyl acetate in hexanes to yield intermediate 1 as a solid 1 h nmr cd 3 od u03b4 ppm 1 15 d j 7 03 hz 6h 1 26 d 6h j 6 74 hz 1 56 d j 7 03 hz 3h 2 34 s 3h 2 58 hept j 7 03 hz 1h 3 34 hept j 7 74 hz 1h 4 42 q j 7 03 hz 1h 5 15 s 2h 7 07 7 10 m 2h 7 12 7 15 m 1h 7 31 s 1h 8 35 s 1h intermediates 2 6 were.