regions of adverse side effect are regions recorded to have been associated with at least a threshold level of adverse side effect without at least a threshold level of therapeutic effect in an alternative example embodiment as described above the regions of adverse side effect are regions assigned a score associated with adverse side effect where the score is based on recorded data of adverse side effect and therapeutic effect where recorded adverse side effects negatively impact the score and recorded therapeutic effects positively impact the score in an example embodiment recorded data concerning adverse side effects and or therapeutic effects are associated with tissue regions that have been previously stimulated often adverse side effects are recorded for stimulation regions in which there is one or more smaller stimulation regions that resulted from other stimulations which other smaller stimulation regions have been associated with therapeutic effect therefore recorded adverse side effect regions can be separated by a therapeutic effect region in an example embodiment multiple region markings 206 are output each corresponding to a respective stimulation significant region 300 for example for a region associated with therapeutic effect that is bounded by regions associated with adverse side effects resulting in two or more separate regions of adverse side.