so that the resulting sizing mixture is suitable for flow to and ultimate deposition on the paper web as described hereinafter the sizing is selected from soaps animal glues starch paste synthetic glues latex products and combinations thereof mixing is complete in about twenty minutes utilizing a water temperature range of between about 70 u00b0 to 200 u00b0 fahrenheit application temperature of the sizing mixture during the paper manufacturing process should be at a temperature range of between about 70 u00b0 180 u00b0 fahrenheit turning once again to the paper manufacturing process the size press passes the prepared sizing mixture into the interstices of the paper fibers from either one or both sides of the paper web depending upon whether antimicrobial protection is desired along both sides of the finished paper product penetration and distribution of the antimicrobial chemicals is thus achieved throughout a substantial portion of the thickness of the paper the ratio of antimicrobial chemicals to sizing in the sizing mixture is from between 0 1 100 and 1 100 and the amount of sizing to be ultimately deposited on the paper web is in the range of between 20 and 100 pounds per ton of produced paper this achieves the application of antimicrobial chemicals of between about 0 02 and 1 pound per ton of paper.