<s>[INST] Given an abstract text, please determine whether it contains any drug mentions. Provide a 'Yes' or 'No' answer based on the presence or absence of drugs. Abstract Text: Upadacitinib Improves Clinical Outcomes In Patients With Moderate To Severely Active Crohn'S Disease Irrespective Of Previous Failure To Respond To Biologics Or Conventional Therapies[/INST] Yes</s>