<s>[INST] Given an abstract text, please determine whether it contains any drug mentions. Provide a 'Yes' or 'No' answer based on the presence or absence of drugs. Abstract Text: Descending Pain Modulation Of Colorectal Nociceptive Processing In The Spinal Cord Is Imbalanced In A Mouse Model Of Post-Colitis Chronic Visceral Hypersensitivity And Is Reduced By Chronic Oral Linaclotide Treatment.[/INST] Yes</s>