Hooker Waterworth will make his first team debut for Shaun Wane's Warriors if selected on Monday.
Hull KR are without Chris Clarkson, James Green, Albert Kelly and Josh Mantellato, who all picked up knocks in the defeat by Hull FC.
They are replaced in the 19-man squad by Will Oakes, Kieran Moran, Joe Wardill and Joe Cator.
Cator has been handed a squad number after impressing for the City of Hull Academy and in recent training sessions with the Robins.
Wigan Warriors (from): Bateman, Bretherton, Burke, Charnley, Clubb, Gelling, Gildart, Gregson, Manfredi, Mossop, O'Loughlin, Powell, Sarginson, Smith, Sutton, Tautai, Tierney, Tomkins, Waterworth.
Hull KR (from): Allgood, Blair, Boudebza, Cator, Cockayne, Dixon, Greenwood, Horne, Lawler, Marsh, Moran, Mulhern, Oakes, Shaw, Sio, Thornley, Tilse, Wardill, Walker.
Luke Waterworth replaces Ben Flower, who sustained a leg injury against St Helens on Friday, in Wigan's squad.