《黄帝内经·灵枢·九针论》
五脏之病的发生，各有其部位与不同的季节：肾为阴脏而主骨，则肾阴的病多发生在骨；心为阳脏而主血，则心阳的病多发生在血；脾为阴脏而主肌肉，则脾阴的病多发生在肌肉；肝为阳脏而主春，则属于肝脏的阳病发源于冬季；肺为阴脏而主秋，则属于肺脏的阴病发源于夏季。邪气侵扰的五种病变：邪气入于阳分而阳盛热极，能使神志受扰而发生狂症。
五发：阴病发于骨，阳病发于血，阴病发于肉，阳病发于冬，阴病发于夏。五邪：邪入于阳，则为狂。
When diseases of the five internal organs occur, the symptoms associated with them vary and change according to the season: the kidneys belong to the yin organs and control the bones, so most diseases associated with kidney yin problems tend to happen in the bones; the heart belongs to the yang organs and controls the blood, so most diseases associated with heart yang problems tend to happen in the blood; the spleen belongs to the yin organs and controls the flesh and muscles, so most diseases associated with spleen yin problems tend to happen in the flesh and muscles; the liver belongs to the yang organs and controls the spring, so most yang diseases associated with the liver tend to manifest in the winter; the lungs belong to the yin organs and control the autumn, so most yin diseases associated with the lungs tend to manifest in the summer. The five disease changes due to attacks by pathogenic factors: if pathogenic factors invade the yang ministerial level and the yang energy is extremely vigorous and hot, it can disturb the mind and cause mania.