《黄帝内经·灵枢·九针十二原》
在病重的时候，如果误泻了五脏阴经的经气，就会造成死亡；而如果误泻了六腑阳经的经气，就使病人形体衰败，难以恢复。误泻阴经，使脏气耗竭，就会导致死亡；误泻阳经，损耗阳气，就会使人发狂，这些都是误用补泻的害处。
故曰：皮肉筋脉各有所处，病各有所宜，各不同形，各以任其所宜。无实，无虚，损不足而益有余，是谓甚病，病益甚。
In case of serious illness, if the qi of the five internal organs' yin meridians is accidentally purged, it will lead to death; and if the qi of the six hollow organs' yang meridians is accidentally purged, the patient's body will decline and it will be difficult to recover. Misusing purgation on the yin meridians will exhaust the qi of the internal organs, leading to death; misusing purgation on the yang meridians will damage the yang qi, causing the patient to go mad. These are all the harms of misusing replenishment and purgation.