there is a moderate interaction with one of the components found in janumet (metformin/sitagliptin) and zantac (ranitidine). ranitidine is a cationic drug and theoretically could decrease the excretion of metformin. this drug interaction has been observed when using another cationic medication cimetidine. because of this we use caution with similar medications. these interactions can increase the risk of lactic acidosis which included symptoms of malaise myalgia respiratory distress hyperventilation slow or irregular heartbeat somnolence abdominal upset or other unusual symptoms. lactic acidosis is a possible side effect from the metformin. consult your health-care professional if both of these medications are being prescribed together. monitor your reactions for side effects of lactic acidosis and stop medication right away if the symptoms occur.
can janumet and zantac be taken together?