yes. think of the sinuses as six separate bony sponges that can fill with mucous. one-sided sinus infection (like the ones below your eyes on each side of your nose called the maxillary sinuses) tend to fill up the most due to gravity when we are upright. during the day the sinuses will drain down into the maxillary areas but if you sleep primarily on one side at night that mucous could migrate to just one of the sinuses - the downside (the side that you lay on).
can one side of your face hurt from sinus infection?