if you look at data on estrogen replacement it may take up to four to six weeks to get a big dent in your hot flashes. and from six to 12 weeks there is a slight improvement; what you see at 12 weeks is about what you get. so don't give up -- if in four to six weeks you don't feel much improvement i'd talk with your doc to get let him or her know -- but there is still considerable hope that you will feel better soon.
i just started combipatch a week ago but am not feeling much better. why is that?