maybe. it depends on the organism that is causing your infection. if you have been squeezing zits or picking at your lesions you could easily have a secondary infection that may or may not be susceptible to mupirocin. you can try it but if you are not quickly improving you should contact your medical provider. assuming this is on your face skin infections can quickly get out of hand if the infection is "deep". as a rule mupirocin is not used to treat acne but it can help certain localized secondary infections.
does mupirocin topical ointment help with acne that has gotten infected?