you're wise to ask this question. whenever someone is taking a pain reliever especially a narcotic it's good to consider whether or not an over-the-counter medication may interact with it. i can't tell if you're referring to oxycodone or oxycontin but either way unisom should not interact with it. the main ingredient in unisom that makes you sleep is a big whopping antihistamine. it's not benadryl (diphenhydramine) but a relative of that. however different over-the-counter sleep aids may contain a different active ingredient from unisom. your best bet is to ask the pharmacist which sleep aid you can safely take with your pain reliever. wishing you well!
can i take a sleeping aid like unisom with oxyodine 5mg