i would really need to know the name of your antidepressant to tell you for sure. i suggest you ask your pharmacist who knows all the medications you are taking and can tell you for sure. most antidepressants can cause drowsiness. promethazine with codeine can cause drowsiness as well. so i would caution you about combining the two. other than that i would need more information to better assist you.
can i safely take promethazine with codeine syrup with my antidepressant?