hi according to drugs com there are no inter-reactions on either of you drugs with depo shot. for your depression have you thought of trying any natural ways if not just google natural ways out of depression lots of ways to try even meditation could be a way out. do hope this helps. good luck
does prednisone interact with depo-provera. i have been told i have lupus symptoms and i take prednisone given by my doctor. i also have been on the depo shot for 6 yrs and take effexor 150mg for depression. can these medicine's interact with my depo shot