it seems that you are suffering from a bipolar affective disorder and currently in the depression phase. according to me your thyroid disturbances should have been treated while taking lithium rather than discontinuing it as lithium is the best medicine for your condition. loss of appetite is due to magnesium valproate tablets as it causes liver dysfunction. i suggest you get a liver function test done. i would advise you try increasing magnesium valproate to minimum 500 mg twice daily and also increase amisulpride in low dose. consult your specialist doctor discuss with him or her and increase the dosage with their consent. before starting bupropion you should have tried minimum effective doses of current medication. i would like to see your recent thyroid profile for better understanding. revert with more information to a psychiatrist online --> <link>
why is the medication for schizophrenic disorder causing weight loss and lethargy?