i am not exactly sure if i understand your question but i do not believe there are any federal regulations that require a medical provider to test tissue removed from a lesion however it is common sense to do so. the only way to know with certainty if a removed or biopsied lesion is benign or malignant is to send it to pathology for a microscopic analysis so most medical providers do this as a standard of care practice not because of any federal requirement.
is there a federal requirement to test tissue removed from a benign lesion?