the answer depends on whether you're about to try an over-the-counter antacid or a long-term prescription drug. each heartburn treatment works differently but in general: antacids such as tums work instantly but wear off quickly. antacids work best if taken 30 to 60 minutes before eating. histamine blockers take effect in about an hour but must be taken twice a day for heartburn prevention. proton pump inhibitors are the most powerful drugs but may not provide immediate relief because they act slowly. these drugs must be taken every day to be effective.
how long does it take for heartburn treatment to work?