it can take 4-6 weeks for this med to work assuming you are at 300mg/day or more. there are no direct effects of this med on alcohol or in reverse. the idea is that alcohol is a donwer and wellbutrin is an upper and both work in the brain is an issue. so there is no 'keel over and die' reaction but theoretically the two work in opposite directions chemically.
how long does it take wellbutrin sr to work and does alcohol affect this medicine?