most helpful answer whenever you take several medications it is important to check with your doctor and pharmacist about drug interactions. you are wise to question the combination of bupropion (wellbutrin) escitalopram (lexapro) and fluconazole (diflucan). bupropion increases your risk of seizures and the addition of escitalopram (lexapro) raises that risk further. this is especially worrisome for the elderly and for those who are at risk for seizures for example from a head injury. presumably the doctor who prescribed both of these medications felt that the benefit of this combination outweighed the risk. sometimes your doctor will need to check your blood levels of escitalopram when bupropion and escitalopram are used together. adding a single dose of fluconazole a fungal medication taken by mouth probably won’t have a significant effect on how you feel. however when fluconazole is used for several days it can raise the blood levels of escitalopram increasing your risk of complications. there are several web sites that allow you to check drug interactions online but the safest path is to check with your doctor. when you are seeing several doctors who are prescribing medications there is a risk that drug interactions between medications will be overlooked. to safeguard against this happening it is always best to have one doctor a family practitioner or internist overseeing all your care. checking with your pharmacist before filling medications is also important.
can you take pills for yeast infection while on antidepressants? . i am taking 10mg escitalopram and 150mg bupropion daily for treatment of depression and have just taken a one-time dose of 150 mg fluconazole (5 hours after the other two medications) for treatment of yeast infection. should i be concerned about drug interactions between these? what would be the signs and symptoms if there was a problem? and will they go away on their own since the fluconazole is just one dose or do i need to see a doctor?