some common causes of hyperthyroidism include: graves' disease. functioning adenoma ("hot nodule") and toxic multinodular goiter (tmng). excessive intake of thyroid hormones. abnormal secretion of thyroid-stimulating hormone (tsh). thyroiditis (inflammation of the thyroid gland). excessive iodine intake. graves' disease graves' disease which is caused by a generalized overactivity of the thyroid gland is the most common cause of hyperthyroidism. in this condition the thyroid gland usually is renegade which means it has lost the ability to respond to the normal control by the pituitary gland via tsh. graves' disease is hereditary and is up to five times more common among women than men. graves' disease is thought to be an autoimmune disease and antibodies that are characteristic of the illness may be found in the blood. these antibodies include thyroid stimulating immunoglobulin (tsi antibodies) thyroid peroxidase antibodies (tpo) and tsh receptor antibodies. graves' disease can be diagnosed by a standard nuclear medicine thyroid scan which shows diffusely increased uptake of a radioactively-labeled iodine. in addition a blood test may reveal elevated tsi levels. functioning adenoma and toxic multinodular goiter the thyroid gland (like many other areas of the body) becomes lumpier as we get older. in the majority of cases these lumps do not produce thyroid hormones and require no treatment. occasionally a nodule may become "autonomous " which means that it does not respond to pituitary regulation via tsh and produces thyroid hormones independently. this becomes more likely if the nodule is larger than 3 cm. when there is a single nodule that is independently producing thyroid hormones it is called a functioning nodule. if there is more than one functioning nodule the term toxic multinodular goiter is used. functioning nodules may be readily detected with a thyroid scan. excessive intake of thyroid hormones taking too much thyroid hormone medication is actually quite common. excessive doses of thyroid hormones frequently go undetected due to the lack of follow-up of patients taking their thyroid medicine. other persons may be abusing the drug in an attempt to achieve other goals such as weight loss. these patients can be identified by having a low uptake of radioactively-labelled iodine (radio-iodine) on a thyroid scan. abnormal secretion of tsh a tumor in the pituitary gland may produce an abnormally high secretion of thyroid-stimulating hormone (tsh). this leads to excessive signaling to the thyroid gland to produce thyroid hormones. this condition is very rare and can be associated with other abnormalities of the pituitary gland. to identify this disorder an endocrinologist performs elaborate tests to assess the release of tsh. thyroiditis (inflammation of the thyroid) inflammation of the thyroid gland may occur after a viral illness (subacute thyroiditis). this condition is associated with a fever and a sore throat that is often painful on swallowing. the thyroid gland is also tender to the touch. there may be generalized neck aches and pains. inflammation of the gland with an accumulation of white blood cells known as lymphocytes (lymphocytic thyroiditis) may also occur. thyroiditis can be diagnosed by a thyroid scan. excessive iodine intake the thyroid gland uses iodine to make thyroid hormones. an excess of iodine may cause hyperthyroidism. iodine-induced hyperthyroidism is usually seen in patients who already have an underlying abnormal thyroid gland. certain medications such as amiodarone (cordarone) which is used in the treatment of heart problems contain a large amount of iodine and may be associated with thyroid function abnormalities.
what causes hyperthyroidism?