most helpful answer yes you can take antihistamines like benadryl while taking prednisone. i have the same issue. i asked the dermatologist and my pcp and they both said it would be safe. it helped me sleep much better!
i am taking prednisone can i take benadryl too? . i have a severe case of poison ivy and have been prescribed 80mg of prednisone. i am still itching at night and having trouble sleeping someone told me that taking 2 benadryl tablets 1/2 hour before going to bed will help me get a good nights sleep with no itching. . is it safe to take them together?