the type of pain you describe is not typical for a standard blister. it does sound possible that you have either gotten an infection or you are experiencing nerve pain from the site of the blister that is moving up your leg. wear shoes that do not irritate the blister. keep the area clean and dry. take ibuprofen for pain if necessary. if this does not clear up in a day or two or if you see obvious signs of serious infection such as: swelling hot inflamed skin overall fever please see your pcp.
two days ago a shoe caused a heel blister. now i have pain all up my calf and can barely walk. what should i do?