Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning.G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and play a critical role as pharmacological targets.  This study used machine learning to classify head and neck squamous cell carcinoma (HNSCC) patients into two GPCR-based subtypes. 
machine learning
Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning.G protein-coupled receptors (GPCRs) are the largest family of membrane proteins and play a critical role as pharmacological targets.  An improved understanding of GPCRs' involvement in tumor microenvironment may provide new perspectives for cancer therapy. 
GPCRs
Upregulation of S1PR4 enhanced T cell function during CAR-T cell therapy, suggesting its potential in cancer immunotherapy. 
CAR-T cell therapy