A novel amalgamation of deep eutectic solvents and crowders as biocompatible solvent media for enhanced structural and thermal stability of bovine serum albumin.Proteins have immense untapped potential in numerous industries as a green catalyst.  While the thermal stability of BSA was dramatically enhanced in the presence of choline chloride (ChCl)-based deep eutectic solvents (DESs) namely ChCl-urea (DES1) and ChCl-glycerol (DES2), the order of stability was (DES1) > (DES2).  It was interesting to note that DES1 possessing urea as a hydrogen bond donor leads to the exceptional thermal stability of the BSA structure.  Fascinatingly, the combination of DES1 with PEG delivers promising results, as they elevate the thermal stability of BSA by approximately 16 °C. 
THERM