Genome-wide DNA methylation data was imported from Gene Expression Omnibus GSE70977 using the GEOquery package. 
Gene Expression Omnibus
Genome-wide DNA methylation data was imported from Gene Expression Omnibus GSE70977 using the GEOquery package. 
GEOquery package
Differential DNA methylation for CpG positions and at the regional level was determined using Limma and DMRcate Bioconductor packages. 
Limma
Differential DNA methylation for CpG positions and at the regional level was determined using Limma and DMRcate Bioconductor packages. 
DMRcate Bioconductor packages