Multi-echo Acquisition and Thermal Denoising Advances Infant Precision Functional Imaging.The characterization of individual functional brain organization with Precision Functional Mapping has provided important insights in recent years in adults.  Here, we investigate the applicability of two such methods from adult MRI research, multi-echo (ME) data acquisition and thermal noise removal with Noise reduction with distribution corrected principal component analysis (NORDIC), in precision fMRI data from three newborn infants.  The application of thermal denoising via NORDIC increased tSNR and the overall strength of functional connections as well as the split-half reliability of functional connectivity matrices in infant ME data. 
THERM