We applied ESTIMATE to evaluate the immune-infiltration landscape of tumor microenvironment. 
ESTIMATE
The co-expression networks were constructed by weighted gene co expression network analysis (WGCNA) and compared with the existing human immune related genes (IRGs) to determine the co-expressed IRGs. 
WGCNA
GSVA combined with CIBERSORT and ssGSEA illustrated the correlation of hub genes and immune infiltration patterns. 
CIBERSORT
GSVA combined with CIBERSORT and ssGSEA illustrated the correlation of hub genes and immune infiltration patterns. 
ssGSEA
TIDE algorithm and Subclass mapping evaluated the function of hub genes in predicting immune function and immunotherapeutic sensitivity. 
TIDE algorithm
TIDE algorithm and Subclass mapping evaluated the function of hub genes in predicting immune function and immunotherapeutic sensitivity. 
Subclass mapping
The pRRophetic was employed in the sensitivity prediction of chemotherapeutic drugs.



pRRophetic