Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway.Colon cancer is a leading cause of cancer-related deaths worldwide.  Then, we found that apigenin effectively inhibits the activity of Snail.  Apigenin could inhibit the EMT, migration, and invasion of human colon cancer cells in vitro and in vivo through the NF-κB/Snail pathway.  Snail is a key regulator of EMT in colon cancer and Snail inhibitor apigenin may be a therapeutic application for patients with colon cancer.
Apigenin
We first evaluated the effects of EMT-related transcription factors on the prognosis of colon cancer through analysis the data obtained from The Cancer Genome Atlas (TCGA). 
TCGA
Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway.Colon cancer is a leading cause of cancer-related deaths worldwide.  First, Snail is a more important EMT transcription factors for colon cancer prognosis, compared with Twist and Slug.  Then, we found that apigenin effectively inhibits the activity of Snail.  Apigenin could inhibit the EMT, migration, and invasion of human colon cancer cells in vitro and in vivo through the NF-κB/Snail pathway.  Snail is a key regulator of EMT in colon cancer and Snail inhibitor apigenin may be a therapeutic application for patients with colon cancer.
Snail
Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway.Colon cancer is a leading cause of cancer-related deaths worldwide. 
NF-κB/Snail signaling pathway