Here, we have overcome these challenges by developing sample-specific multidimensional lipid libraries using the freely available software Skyline.  Specifically, the human plasma library developed for this work contains over 500 unique lipids and is combined with adapted Skyline functions such as indexed retention time (iRT) for retention time prediction and IMS drift time filtering for enhanced selectivity. 
Skyline
Here, we have overcome these challenges by developing sample-specific multidimensional lipid libraries using the freely available software Skyline.  Specifically, the human plasma library developed for this work contains over 500 unique lipids and is combined with adapted Skyline functions such as indexed retention time (iRT) for retention time prediction and IMS drift time filtering for enhanced selectivity. 
Skyline