In this study, we developed an in silico model to simulate the effect of surface curvature on the osteoconduction of scaffold implants, which comprises the primary aspects of bone regeneration. 
in silico model
Selective laser melting was used to manufacture a titanium scaffold with channels representative of different strut curvatures for in vivo assessment.  The predictions of the mathematical model are in good agreement with the in vivo assessment results, in which newly formed bone first appeared adjacent to the vertices of the major axes in elliptical channels. 
in vivo assessment