The assessment of BV was measured by a non-commercial software, uAI Research Portal. 
uAI Research Portal
The effect on brain volume in HIV-negative and non-transplant cryptococcal meningitis.To explore the brain volume (BV) changes of HIV-negative and non-transplant cryptococcal meningitis (CM) in 1 year after initial therapy.  Case data were collected from 78 CM patients who underwent magnetic resonance imaging (MRI) scanning at least 3 times in 1-year interval after initial therapy.  The assessment of BV was measured by a non-commercial software, uAI Research Portal.  Linear mixed model was used to investigate the association between clinical characteristics and the changes in BV.  Longitudinal study showed a decrease in total brain volume (-4.65 cm3, P = .005), regional brain volume including white matter (-2.86 cm3, P = .031) and basal ganglia (-0.25 cm3, P = .007), and increase in cerebrospinal fluid (CSF) volume (3.58 cm3, P = .013) in CM patients in 1 year after initial therapy.  Ventricular volume in patients with ventriculoperitoneal shunts (VPS) was lower than that in patients without VPS (-7.5 cm3, P < .05).  Ventricular volume in patients with post-infectious inflammatory response syndrome (PIIRS) was larger than that in patients without PIIRS (7.1 cm3, P < .01).  In addition, temporal lobe atrophy was associated with corticosteroid therapy (-6.8 cm3, P < .01).  The present study suggested that brain atrophy, especially regional BV decrease, could happen in HIV-negative and non-transplant CM patients over a 1-year interval.
C