"Stripe" transcription factors provide accessibility to co-binding partners in mammalian genomes.Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific motifs.  We uncover two TF groups that colocalize with most expressed factors, forming stripes in hierarchical clustering maps.  The second one, dubbed universal stripe factors (USFs), comprises ∼30 SP, KLF, EGR, and ZBTB family members that recognize overlapping GC-rich sequences in all tissues analyzed. 
Stripe