Regulostat Inferelator: a novel network biology platform to uncover molecular devices that predetermine cellular response phenotypes.With the emergence of genome editing technologies and synthetic biology, it is now possible to engineer genetic circuits driving a cell's phenotypic response to a stressor.  To address this gap, we devised a novel Regulostat Inferelator (RSI) algorithm to decipher intrinsic molecular devices or networks that predetermine cellular phenotypic responses. 
Regulostat Inferelator
The RSI algorithm is designed to extract gene expression patterns from basal transcriptomic data in order to identify 'regulostat' constituent gene pairs, which exhibit rheostat-like mode-of-cooperation capable of fine-tuning cellular response. 
RSI algorithm