The role of capsule aperture size on the dispersion of carrier-based formulation at different air flowrates.The effect of capsule aperture size on the aerosol performance of lactose blend formulation was studied using Foradil® (containing 12 μg of formoterol fumarate (FF1) and 24 mg of lactose) dispersed with a powder inhaler Aerolizer® at increasing air flowrates. 
Foradil
The role of capsule aperture size on the dispersion of carrier-based formulation at different air flowrates.The effect of capsule aperture size on the aerosol performance of lactose blend formulation was studied using Foradil® (containing 12 μg of formoterol fumarate (FF1) and 24 mg of lactose) dispersed with a powder inhaler Aerolizer® at increasing air flowrates. 
Aerolizer
The formulation was dispersed into a Next Generation Impactor (NGI) at 30, 60 and 90 L/min, with the fine particle fractions (FPFrec and FPFem) measured by chemical assay of FF and lactose using high-performance liquid chromatography. 
Next Generation Impactor (NGI)
The formulation was dispersed into a Next Generation Impactor (NGI) at 30, 60 and 90 L/min, with the fine particle fractions (FPFrec and FPFem) measured by chemical assay of FF and lactose using high-performance liquid chromatography. 
high-performance liquid chromatography
Particle size distribution (PSD) of FF particles dispersed in wet media was also characterized by laser diffraction.  The laser diffraction studies demonstrated the presence of large agglomerates.
laser diffraction