Three data sets were downloaded from the Gene Expression Omnibus database and analysed by Gene Expression Omnibus 2R. 
Gene Expression Omnibus
Functional enrichment analyses were performed by Metascape. 
Metascape
We use the STRING data to build a protein-protein interaction network. 
STRING
The targets of differentially expressed microRNA (DE miRNA) were predicted by the miRWalk database. 
miRWalk database
Small-molecule drugs were predicted on connectivity map.



Connectivity Map