Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice.Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine playing crucial role in immunity.  Pre-treatment of mice with compound (24) exaggerated the hypothermic response to high dose of bacterial endotoxin.  Our experiments suggest that tetralones and their derivatives inhibit MIF's tautomeric functions and regulate macrophage activation and thermal changes in severe forms of systemic inflammation.
THERM