Genetic Algorithms as a Tool for Dosing Guideline Optimization: Application to Intermittent Infusion Dosing for Vancomycin in Adults.This paper demonstrates the use of a genetic algorithm (GA) for the optimization of a dosing guideline. 
Genetic Algorithms
Genetic Algorithms as a Tool for Dosing Guideline Optimization: Application to Intermittent Infusion Dosing for Vancomycin in Adults.This paper demonstrates the use of a genetic algorithm (GA) for the optimization of a dosing guideline.  GAs are well-suited to derive combinations of doses and dosing intervals that go into a dosing guideline when the number of possible combinations rule out the calculation of all possible outcomes.  GAs also allow for different constraints to be imposed on the optimization process to safeguard the clinical feasibility of the dosing guideline.  In this work, we demonstrate the use of a GA for the optimization of intermittent vancomycin administration in adult patients.  The GA-based optimal solution is compared with the Scottish Antimicrobial Prescribing Group vancomycin guideline.
GA
GAs are well-suited to derive combinations of doses and dosing intervals that go into a dosing guideline when the number of possible combinations rule out the calculation of all possible outcomes.  GAs also allow for different constraints to be imposed on the optimization process to safeguard the clinical feasibility of the dosing guideline. 
GAs