Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.We developed subclone multiplicity allocation and somatic heterogeneity (SMASH), a new statistical method for intra-tumor heterogeneity (ITH) inference.  SMASH is tailored to the purpose of large-scale association studies with one tumor sample per patient.  In a pan-cancer study of 14 cancer types, we studied the associations between survival time and ITH quantified by SMASH, together with other features of somatic mutations.  SMASH is available at https://github.com/Sun-lab/SMASH .
SMASH
Associating somatic mutations to clinical outcomes: a pan-cancer study of survival time.We developed subclone multiplicity allocation and somatic heterogeneity (SMASH), a new statistical method for intra-tumor heterogeneity (ITH) inference.  SMASH is tailored to the purpose of large-scale association studies with one tumor sample per patient.  In a pan-cancer study of 14 cancer types, we studied the associations between survival time and ITH quantified by SMASH, together with other features of somatic mutations.  SMASH is available at https://github.com/Sun-lab/SMASH .
SMASH