The present exploration focuses to explore the beneficial effects of butein on the different chemical and thermal-provoked nociceptive and inflammatory mice models.


 The nociception was induced to the Swiss mice using different chemical (formalin, acetic acid, glutamate, and capsaicin) and thermal (hot plate and tail immersion) methods.  The present findings clearly demonstrated that the butein was substantially lessened the different thermal and chemical provoked nociception in mice. 
THERM