Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells.Nucleotide excision repair (NER) pathway is a DNA repair mechanism that rectifies a wide spectrum of DNA lesions.  We have earlier studied XPA homolog from Hydra (HyXPA) and found it to be similar to human XPA.  This could be attributed to changes in certain amino acid residues that have occurred during evolution, leading to prevention of some interactions between Hydra and human proteins.
Hydra
Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells.Nucleotide excision repair (NER) pathway is a DNA repair mechanism that rectifies a wide spectrum of DNA lesions.  Here, we examined if HyXPA can functionally complement human XPA-deficient cells and reduce their sensitivity to UV radiation. 
human XPA-deficient cells
Xeroderma pigmentosum A homolog from Hydra partially complements DNA repair defect in human XPA-deficient cells.Nucleotide excision repair (NER) pathway is a DNA repair mechanism that rectifies a wide spectrum of DNA lesions.  Xeroderma pigmentosum group of proteins (XPA through XPG) orchestrate the NER pathway in humans.  However, HyXPA failed to bind replication protein A (RPA70), a key interacting partner of human XPA in NER pathway. 
NER
Xeroderma pigmentosum group of proteins (XPA through XPG) orchestrate the NER pathway in humans. 
Xeroderma pigmentosum group of proteins (XPA through XPG)
However, HyXPA failed to bind replication protein A (RPA70), a key interacting partner of human XPA in NER pathway. 
RPA70