Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing.DNA methylation is an epigenetic process that controls DNA accessibility and serves as a transcriptomic switch when deposited at regulatory regions. 
CRISPR/Cas9
Here, we have taken advantage of CRISPR/dCas9 technology adapted for epigenetic editing through site-specific targeting of DNA methylation to characterize the transcriptional changes of the candidate gene and the functional effects on cell fate in different tumor settings. 
CRISPR/dCas9 technology