Coactivation of Endogenous Wnt10b and Foxc2 by CRISPR Activation Enhances BMSC Osteogenesis and Promotes Calvarial Bone Regeneration.CRISPR activation (CRISPRa) is a burgeoning technology for programmable gene activation, but its potential for tissue regeneration has yet to be fully explored. 
CRISPR activation
We constructed a Bac-CRISPRa vector to deliver the SAM-based CRISPRa system into rat BMSCs. 
Bac-CRISPRa vector
We constructed a Bac-CRISPRa vector to deliver the SAM-based CRISPRa system into rat BMSCs. 
SAM-based CRISPRa system