ACCELERATE: A Patient-Powered Natural History Study Design Enabling Clinical and Therapeutic Discoveries in a Rare Disorder.Geographically dispersed patients, inconsistent treatment tracking, and limited infrastructure slow research for many orphan diseases.  Here, we report initial results from the ACCELERATE natural history registry.  ACCELERATE includes a traditional physician-reported arm and a patient-powered arm, which enables patients to directly contribute medical data and biospecimens. 
ACCELERATE
We assess the feasibility of a patient-powered study design to overcome these challenges for Castleman disease, a rare hematologic disorder. 
Castleman disease
ACCELERATE includes a traditional physician-reported arm and a patient-powered arm, which enables patients to directly contribute medical data and biospecimens.  A median of 683 clinical, laboratory, and imaging data elements are captured per patient in the patient-powered arm compared with 37 in the physician-reported arm. 
patient-powered arm
ACCELERATE includes a traditional physician-reported arm and a patient-powered arm, which enables patients to directly contribute medical data and biospecimens.  A median of 683 clinical, laboratory, and imaging data elements are captured per patient in the patient-powered arm compared with 37 in the physician-reported arm. 
physician-reported arm