In this paper, we present a portable, low-cost time-correlated single photon-counting (TCSPC) analysis system for DNA detection.  The time-to-digital module of the proposed TCSPC system achieves a full width at half maximum (FWHM) timing resolution from 121 to 145 ps and a differential non-linearity (DNL) between -8.5% and +9.7% of the least significant bit (LSB) within the 500 ns full-scale range (FSR).  With a detection limit of 6.25 nM and a dynamic range of 6.8 ns, the proposed TCSPC system demonstrates the enabling technology for rapid, point-of-care DNA diagnostics.
TCSPC
In this paper, we present a portable, low-cost time-correlated single photon-counting (TCSPC) analysis system for DNA detection.  The time-to-digital module of the proposed TCSPC system achieves a full width at half maximum (FWHM) timing resolution from 121 to 145 ps and a differential non-linearity (DNL) between -8.5% and +9.7% of the least significant bit (LSB) within the 500 ns full-scale range (FSR).  With a detection limit of 6.25 nM and a dynamic range of 6.8 ns, the proposed TCSPC system demonstrates the enabling technology for rapid, point-of-care DNA diagnostics.
TCSPC