Furthermore, eIF4A3 overexpression markedly reversed the significant down-regulation of PTEN protein level and the activation of PI3K/AKT/mTOR pathway in CD4+ T cells transfected with Lv-circ_0002594, suggesting the involvement of circ_0002594/eIF4A3/PTEN axis in the activation of PI3K/AKT/mTOR pathway. 
THERM
Furthermore, eIF4A3 overexpression markedly reversed the significant down-regulation of PTEN protein level and the activation of PI3K/AKT/mTOR pathway in CD4+ T cells transfected with Lv-circ_0002594, suggesting the involvement of circ_0002594/eIF4A3/PTEN axis in the activation of PI3K/AKT/mTOR pathway. 
THERM
Furthermore, eIF4A3 overexpression markedly reversed the significant down-regulation of PTEN protein level and the activation of PI3K/AKT/mTOR pathway in CD4+ T cells transfected with Lv-circ_0002594, suggesting the involvement of circ_0002594/eIF4A3/PTEN axis in the activation of PI3K/AKT/mTOR pathway. 
THERM
Furthermore, eIF4A3 overexpression markedly reversed the significant down-regulation of PTEN protein level and the activation of PI3K/AKT/mTOR pathway in CD4+ T cells transfected with Lv-circ_0002594, suggesting the involvement of circ_0002594/eIF4A3/PTEN axis in the activation of PI3K/AKT/mTOR pathway. 
THERM