NO-mediated activation of KATP channels contributes to cutaneous thermal hyperemia in young adults.Local skin heating to 42°C causes cutaneous thermal hyperemia largely via nitric oxide (NO) synthase (NOS)-related mechanisms.  We assessed the hypothesis that ATP-sensitive K+ (KATP) channels interact with NOS to mediate cutaneous thermal hyperemia.  Local skin heating to 42°C was administered at all four treatment sites to elicit cutaneous thermal hyperemia.  In summary, we showed an interactive effect of KATP channels and NOS for the plateau of cutaneous thermal hyperemia. 
THERM