A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.CD3-bispecific antibodies represent an important therapeutic strategy in oncology.  Here, we devised whole-genome CRISPR screens to identify cancer resistance mechanisms to CD3-bispecific antibodies across multiple targets and cancer types. 
CRISPR
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.CD3-bispecific antibodies represent an important therapeutic strategy in oncology. 
CD3-Bispecific Antibody Therapy