Photoactivatable AMPA for the study of glutamatergic neuronal transmission using two-photon excitation.We report a photoactivatable agonist of the AMPA subtype of ionotropic glutamate receptors, TMP-CyHQ-AMPA, which was designed to study the fast excitatory transmission between neurons.  Upon visible light excitation, TMP-CyHQ-AMPA quantitatively released AMPA in high quantum yield on an ultra-short timescale.  TMP-CyHQ-AMPA is soluble in pysiological buffer and no hydrolysis was detected in the absence of light.  TMP-CyHQ-AMPA can be used to study glutamatergic neuronal transmission with exceptional spatial-temporal resolution in complex tissue preparations.
TMP-CyHQ-AMPA
Photoactivatable AMPA for the study of glutamatergic neuronal transmission using two-photon excitation.We report a photoactivatable agonist of the AMPA subtype of ionotropic glutamate receptors, TMP-CyHQ-AMPA, which was designed to study the fast excitatory transmission between neurons.  Upon visible light excitation, TMP-CyHQ-AMPA quantitatively released AMPA in high quantum yield on an ultra-short timescale.  TMP-CyHQ-AMPA is soluble in pysiological buffer and no hydrolysis was detected in the absence of light.  TMP-CyHQ-AMPA can be used to study glutamatergic neuronal transmission with exceptional spatial-temporal resolution in complex tissue preparations.
TMP-CyHQ-AMPA
Photoactivatable AMPA for the study of glutamatergic neuronal transmission using two-photon excitation.We report a photoactivatable agonist of the AMPA subtype of ionotropic glutamate receptors, TMP-CyHQ-AMPA, which was designed to study the fast excitatory transmission between neurons.  Upon visible light excitation, TMP-CyHQ-AMPA quantitatively released AMPA in high quantum yield on an ultra-short timescale.  TMP-CyHQ-AMPA is soluble in pysiological buffer and no hydrolysis was detected in the absence of light.  TMP-CyHQ-AMPA can be used to study glutamatergic neuronal transmission with exceptional spatial-temporal resolution in complex tissue preparations.
TMP-CyHQ-AMPA
Photoactivatable AMPA for the study of glutamatergic neuronal transmission using two-photon excitation.We report a photoactivatable agonist of the AMPA subtype of ionotropic glutamate receptors, TMP-CyHQ-AMPA, which was designed to study the fast excitatory transmission between neurons.  Upon visible light excitation, TMP-CyHQ-AMPA quantitatively released AMPA in high quantum yield on an ultra-short timescale.  TMP-CyHQ-AMPA is soluble in pysiological buffer and no hydrolysis was detected in the absence of light.  TMP-CyHQ-AMPA can be used to study glutamatergic neuronal transmission with exceptional spatial-temporal resolution in complex tissue preparations.
TMP-CyHQ-AMPA