In addition, MHC expression studies or evolutionary studies, for example, can be greatly improved in this way, and the method should be applicable to a broader spectrum of other multigene families or highly polymorphic genes.
THERM
The method allows the comprehensive discovery of novel MHC class I alleles from RNA-Seq data (DinoMfRS).


 Using DinoMfRS, virtually all expressed MHC class I alleles could be determined.  In addition, it was shown that DinoMfRS can be used to improve the annotation of MHC genes in the sheep genome sequence.


 DinoMfRS allows for the first time the annotation of unknown, more divergent MHC alleles from RNA-Seq data. 
DinoMfRS