This enzyme is efficiently used for acute lymphoblastic leukemia (ALL) and lymphosarcoma and emerged against ALL in children, neoplasia, and some other malignancies.  Thermal or harsh conditions stability of those from the two latter bacterial species is considerable.  Furthermore, the possibility of anticancer combination therapy using two or more l-asparaginases from various sources is plausible in future studies to achieve better therapeutic outcomes with lower side effects.
THERM
Application of software such as RSM would optimize conditions for higher levels of enzyme production. 
RSM