Systems Biology Model of Cerebral Oxygen Delivery and Metabolism During Therapeutic Hypothermia: Application to the Piglet Model.Hypoxic ischaemic encephalopathy (HIE) is a significant cause of death and disability.  Therapeutic hypothermia (TH) is the only available standard of treatment, but 45-55% of cases still result in death or neurodevelopmental disability following TH.  This work demonstrates the use of systems biology models to investigate underlying mechanisms behind the varying response to hypothermic treatment.
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