Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed by the clusterProfiler program package. 
clusterProfiler
Differentially expressed genes (DEGs) were identified by the DESeqDataSetFromMatrix function of the DESeq2 program package. 
DESeq2
The protein-protein interaction (PPI) network analyses were implemented using the STRING online tool and visualized with Cytoscape software. 
STRING online tool
The protein-protein interaction (PPI) network analyses were implemented using the STRING online tool and visualized with Cytoscape software. 
Cytoscape software