This study investigates the effectiveness of demineralized bone matrix (DBX) to close alveolar clefts in patients previously treated with bone morphogenic protein-2 (BMP-2) who remained with bone nonunion.


 17 patients underwent revision alveolar bone grafting (ABG) with either DBX (n = 10) or autograft (n = 7) to repair persistent bony cleft.


 58.8% of patients were treated with DBX in the cleft, 41.2% treated with autograft from iliac crest.  DBX and autologous iliac crest bone grafts achieve similar alveolar union rates during revision ABG in patients treated with previous BMP-2 to the alveolar cleft.
DBX
17 patients underwent revision alveolar bone grafting (ABG) with either DBX (n = 10) or autograft (n = 7) to repair persistent bony cleft.


 58.8% of patients were treated with DBX in the cleft, 41.2% treated with autograft from iliac crest.  The average time to reoperation was 2.06 years, and both were re-grafted with autograft. 
autograft