Furthermore, an in vivo pharmacokinetic study in Sprague-Dawley rats following oral administration displayed a 1.46-fold enhancement in the relative bioavailability of the nanosuspension in contrast to neat nilotinib.
THERM
Systematic optimization was carried out by employing the I-optimal method using Design Expert® software with a concentration of HPMCAS and Soluplus® as independent variables and evaluating them for responses viz particle size, polydispersity index (PDI), and zeta potential. 
Design Expert