Nomogram for predicting the survival of gastric adenocarcinoma patients who receive surgery and chemotherapy.BACKGROUND
 A significant prognostic nomogram for predicting the respective disease-specific survival (DSS) rates of GAC patients who receive surgery and chemotherapy has not been established.


 We were planning to establish a survival nomogram model for GAC patients who receive surgery and chemotherapy.


 A prognostic nomogram was constructed by the training set and the predictive accuracy of it was validated by the validation set.


 Based on the outcome of a multivariate analysis of candidate factors, a nomogram was developed that encompassed age at diagnosis, number of regional lymph nodes examined after surgery, number of positive regional lymph nodes, sex, race, grade, derived AJCC stage, summary stage, and radiotherapy status.  The C-index (Harrell's concordance index) of the nomogram model was some larger than that of the traditional seventh AJCC staging system (0.707 vs 0.661).  Calibration plots of the constructed nomogram displayed that the probability of DSS commendably accord with the survival rate.  Decision curve analysis (DCA) proved that the constructed nomogram was preferable to the AJCC staging system.


 The constructed nomogram supplies more credible DSS predictions for GAC patients who receive surgery and chemotherapy in the general population.  According to validation, the new nomogram will be beneficial in facilitating individualized survival predictions and useful when performing clinical decision-making for GAC patients who receive surgery and chemotherapy.
Nomogram