Cavity Click Chemistry: Cavity-Catalyzed Azide-Alkyne Cycloaddition.Click chemistry, which refers to chemical reactions that are fast and selective with high product yields, has become a powerful approach in organic synthesis and chemical biology. 
Cavity Click Chemistry
Cavity Click Chemistry: Cavity-Catalyzed Azide-Alkyne Cycloaddition.Click chemistry, which refers to chemical reactions that are fast and selective with high product yields, has become a powerful approach in organic synthesis and chemical biology.  Due to the cytotoxicity of the transition metals employed in click chemistry reactions, a search for novel metal-free alternatives continues.  Herein, we demonstrate that an optical cavity can be utilized as a metal-free alternative in the click chemistry cycloaddition reaction between cyanoacetylene and formylazide using the quantum electrodynamics coupled cluster method.  This work highlights that a cavity has the same effect on the investigated cycloaddition as the transition metal catalysts traditionally employed in click chemistry reactions.  We expect our findings to further stimulate research on cavity-assisted click chemistry reactions.
click chemistry
Herein, we demonstrate that an optical cavity can be utilized as a metal-free alternative in the click chemistry cycloaddition reaction between cyanoacetylene and formylazide using the quantum electrodynamics coupled cluster method. 
quantum electrodynamics coupled cluster method