Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits.  Fyn kinase physically associates with Tau and regulates subcellular distribution.  Here, we assessed whether pharmacological Fyn inhibition alters Tauopathy.  In P301S transgenic mice, chronic Fyn inhibition prevented deficits in spatial memory and passive avoidance learning.  In this model, Fyn inhibition beginning 24 h after the trauma ended rescued memory performance and reduced phospho-Tau accumulation.  Thus, inhibition of Fyn kinase may have therapeutic benefit in clinical Tauopathies.
Fyn
Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.Accumulation of misfolded phosphorylated Tau (Tauopathy) can be triggered by mutations or by trauma, and is associated with synapse loss, gliosis, neurodegeneration and memory deficits.  Here, we assessed whether pharmacological Fyn inhibition alters Tauopathy. 
Tauopathy
In P301S transgenic mice, chronic Fyn inhibition prevented deficits in spatial memory and passive avoidance learning. 
P301S transgenic mice
We extended this analysis to a trauma model in which very mild repetitive closed head injury was paired with chronic variable stress over 2 weeks to produce persistent memory deficits and Tau accumulation. 
chronic variable stress
Here, we assessed whether pharmacological Fyn inhibition alters Tauopathy.  In P301S transgenic mice, chronic Fyn inhibition prevented deficits in spatial memory and passive avoidance learning.  In this model, Fyn inhibition beginning 24 h after the trauma ended rescued memory performance and reduced phospho-Tau accumulation. 
Fyn inhibition