Multifunctional Detection of Extracellular Vesicles with Surface Plasmon Resonance Microscopy.Extracellular vesicles (EVs), including exosomes, are promising circulating biomarkers for disease diagnosis. 
Surface Plasmon Resonance Microscopy
The system is based on a functionalized surface plasmon resonance (SPR) biosensor and an advanced plasmonic microscopy to capture and image EVs at single-particle level. 
plasmonic microscopy
SPR images are processed with a home-developed deep learning algorithm to identify EVs and quantify image intensity automatically. 
deep learning algorithm