Colonic mucosal diffuse congestion associated with Osimertinib.INTRODUCTION
 Osimertinib has been recommended as first-line treatment of advanced NSCLC with EGFR mutations.  Previous studies have only reported cases of gastrointestinal bleeding due to Erlotinib and gefitinib, but to date, always no cases of gastrointestinal bleeding due to Osimertinib have been reported.


 After 1.5 years of treatment with Osimertinib, a colonoscopy showed diffuse congestion of the colonic mucosa.


 The patient's symptoms of blood in the stool disappeared, after stopping Osimertinib and giving mucosal protection treatment for 1 week.


 Osimertinib may have contributed to gastrointestinal bleeding because no recurrent bleeding was observed after discontinuation of treatment.  Physicians and patients should be aware that osimertinib may increase the risk of gastrointestinal bleeding.
Osimertinib
Colonic mucosal diffuse congestion associated with Osimertinib.INTRODUCTION
 Osimertinib has been recommended as first-line treatment of advanced NSCLC with EGFR mutations.  Previous studies have only reported cases of gastrointestinal bleeding due to Erlotinib and gefitinib, but to date, always no cases of gastrointestinal bleeding due to Osimertinib have been reported.


 After 1.5 years of treatment with Osimertinib, a colonoscopy showed diffuse congestion of the colonic mucosa.


 The patient's symptoms of blood in the stool disappeared, after stopping Osimertinib and giving mucosal protection treatment for 1 week.


 Osimertinib may have contributed to gastrointestinal bleeding because no recurrent bleeding was observed after discontinuation of treatment.  Physicians and patients should be aware that osimertinib may increase the risk of gastrointestinal bleeding.
Osimertinib
Colonic mucosal diffuse congestion associated with Osimertinib.INTRODUCTION
 Osimertinib has been recommended as first-line treatment of advanced NSCLC with EGFR mutations.  Previous studies have only reported cases of gastrointestinal bleeding due to Erlotinib and gefitinib, but to date, always no cases of gastrointestinal bleeding due to Osimertinib have been reported.


 After 1.5 years of treatment with Osimertinib, a colonoscopy showed diffuse congestion of the colonic mucosa.


 The patient's symptoms of blood in the stool disappeared, after stopping Osimertinib and giving mucosal protection treatment for 1 week.


 Osimertinib may have contributed to gastrointestinal bleeding because no recurrent bleeding was observed after discontinuation of treatment.  Physicians and patients should be aware that osimertinib may increase the risk of gastrointestinal bleeding.
Osimertinib