Fetal death from SARS-CoV-2 mediated acute placental failure.INTRODUCTION
 We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.


 Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.


 Histologic changes in the placenta correlate with SARS-CoV-2 infection.  Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2.  Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.


 Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive.  It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. 
SARS-CoV-2
Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.



RT-PCR
Fetal death from SARS-CoV-2 mediated acute placental failure.INTRODUCTION
 We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.


 Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.


 Histologic changes in the placenta correlate with SARS-CoV-2 infection.  Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2.  Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.


 Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive.  It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. 
SARS-CoV-2
Fetal death from SARS-CoV-2 mediated acute placental failure.INTRODUCTION
 We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.


 Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.


 Histologic changes in the placenta correlate with SARS-CoV-2 infection.  Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2.  Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.


 Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive.  It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. 
SARS-CoV-2
Fetal death from SARS-CoV-2 mediated acute placental failure.INTRODUCTION
 We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure.


 Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus.


 Histologic changes in the placenta correlate with SARS-CoV-2 infection.  Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2.  Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant.


 Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive.  It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. 
SARS-CoV-2