DispHred: A Server to Predict pH-Dependent Order-Disorder Transitions in Intrinsically Disordered Proteins.The natively unfolded nature of intrinsically disordered proteins (IDPs) relies on several physicochemical principles, of which the balance between a low sequence hydrophobicity and a high net charge appears to be critical.  On that basis, we developed DispHred, the first pH-dependent predictor of protein disorder.  Despite its simplicity, DispHred displays very high accuracy in identifying pH-induced order/disorder protein transitions.  DispHred might be useful for diverse applications, from the analysis of conditionally disordered segments to the synthetic design of disorder tags for biotechnological applications. 
DispHred
DispHred: A Server to Predict pH-Dependent Order-Disorder Transitions in Intrinsically Disordered Proteins.The natively unfolded nature of intrinsically disordered proteins (IDPs) relies on several physicochemical principles, of which the balance between a low sequence hydrophobicity and a high net charge appears to be critical.  On that basis, we developed DispHred, the first pH-dependent predictor of protein disorder.  Despite its simplicity, DispHred displays very high accuracy in identifying pH-induced order/disorder protein transitions.  DispHred might be useful for diverse applications, from the analysis of conditionally disordered segments to the synthetic design of disorder tags for biotechnological applications. 
DispHred