48 h Normothermic Machine Perfusion With Urine Recirculation for Discarded Human Kidney Grafts.Normothermic machine perfusion (NMP) has reshaped organ preservation in recent years.  In this preclinical study, prolonged normothermic perfusions of discarded human kidney grafts were performed in order to investigate perfusion dynamics and identify potential quality and assessment indicators.  Five human discarded kidney grafts were perfused normothermically (37°C) for 48 h using the Kidney Assist device with a red-blood-cell based perfusate with urine recirculation.  Ex vivo normothermic perfusion is able to identify patterns of perfusion, biological function, and changes in inflammatory markers in heterogenous discarded kidney grafts.
THERM