Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1
Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate.The basal cell compartment in many epithelial tissues is generally believed to serve as an important pool of stem cells.  Here we uncover that the core epithelial-to-mesenchymal transition (EMT) inducer Zeb1 is expressed in a prostate basal cell subpopulation.  The Zeb1+ prostate epithelial cells are multipotent prostate basal stem cells (PBSCs) that can self-renew and generate functional prostatic glandular structures at the single-cell level.  Genetic ablation studies reveal an indispensable role for Zeb1 in prostate basal cell development.  Utilizing unbiased single-cell transcriptomic analysis of over 9000 mouse prostate basal cells, we confirm the existence of the Zeb1+ basal cell subset.  Moreover, Zeb1+ epithelial cells can be detected in mouse and human prostate tumors. 
Zeb1