High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212.Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases.  To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperidine with basic moieties of varying size and degree of conformational freedom. 
PB212
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212.Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases.  To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperidine with basic moieties of varying size and degree of conformational freedom. 
PB212
High-affinity sigma-1 (σ1) receptor ligands based on the σ1 antagonist PB212.Aim: The σ1 receptor is a druggable target involved in many physiological processes and diseases.  To clarify its physiology and derive therapeutic benefit, nine analogs based on the σ1 antagonist PB212 were synthesized replacing the 4-methylpiperidine with basic moieties of varying size and degree of conformational freedom. 
PB212