Allosteric mechanism of the circadian protein Vivid resolved through Markov state model and machine learning analysis.The fungal circadian clock photoreceptor Vivid (VVD) contains a photosensitive allosteric light, oxygen, voltage (LOV) domain that undergoes a large N-terminal conformational change.  We answered this question through a novel computational platform integrating Markov state models, machine learning methods, and newly developed community analysis algorithms. 
Markov state model
We answered this question through a novel computational platform integrating Markov state models, machine learning methods, and newly developed community analysis algorithms. 
machine learning methods