To achieve temporal and qualitative control on CAR-T function, we engineered the Adapter CAR (AdCAR) system.  AdCAR-T are redirected to surface antigens via biotin-labeled adapter molecules in the context of a specific linker structure, referred to as Linker-Label-Epitope.  AdCAR-T execute highly specific and controllable effector function against a multiplicity of target antigens.  In mice, AdCAR-T durably eliminate aggressive lymphoma.  Importantly, AdCAR-T might prevent antigen evasion by combinatorial simultaneous or sequential targeting of multiple antigens and are capable to identify and differentially lyse cancer cells by integration of adapter molecule-mediated signals based on multiplex antigen expression profiles.  In consequence the AdCAR technology enables controllable, flexible, combinatorial, and selective targeting.
AdCAR
AdCAR-T are redirected to surface antigens via biotin-labeled adapter molecules in the context of a specific linker structure, referred to as Linker-Label-Epitope.  AdCAR-T execute highly specific and controllable effector function against a multiplicity of target antigens.  In mice, AdCAR-T durably eliminate aggressive lymphoma.  Importantly, AdCAR-T might prevent antigen evasion by combinatorial simultaneous or sequential targeting of multiple antigens and are capable to identify and differentially lyse cancer cells by integration of adapter molecule-mediated signals based on multiplex antigen expression profiles. 
AdCAR-T
To achieve temporal and qualitative control on CAR-T function, we engineered the Adapter CAR (AdCAR) system.  AdCAR-T are redirected to surface antigens via biotin-labeled adapter molecules in the context of a specific linker structure, referred to as Linker-Label-Epitope.  AdCAR-T execute highly specific and controllable effector function against a multiplicity of target antigens.  In mice, AdCAR-T durably eliminate aggressive lymphoma.  Importantly, AdCAR-T might prevent antigen evasion by combinatorial simultaneous or sequential targeting of multiple antigens and are capable to identify and differentially lyse cancer cells by integration of adapter molecule-mediated signals based on multiplex antigen expression profiles.  In consequence the AdCAR technology enables controllable, flexible, combinatorial, and selective targeting.
AdCAR