The data was processed with Progenesis QI software for multidimensional statistical analysis. 
Progenesis QI
Searching the Human Metabolome Database (HMDB) , differential metabolites were imported into MetaboAnalyst 4.0 to analyze the metabolic pathways. 
MetaboAnalyst 4.0
Searching the Human Metabolome Database (HMDB) , differential metabolites were imported into MetaboAnalyst 4.0 to analyze the metabolic pathways. 
Human Metabolome Database (HMDB)