Graphene liquid cell (GLC) TEM offers a platform to directly investigate nanoparticles in their solution phase. 
Graphene liquid cell (GLC) TEM
Moreover, exploiting high-resolution TEM images of single rotating nanoparticles in GLCs, 3D atomic structures of nanoparticles are reconstructed by a method called "Brownian one-particle reconstruction". 
Brownian one-particle reconstruction