Simulation analysis and physiological and biochemical evaluation of Sophora flavescens aboveground against aphids using network pharmacology.Pests cause substantial damage to human environments; therefore, studying insecticidal mechanisms is crucial for improving pest control.  In this study, we used network pharmacology to investigate the effect of Sophora flavescens Alt. Enzyme activity assays validated the feasibility of network pharmacology to obtain actionable targets.  We used interdisciplinary integration to study pest control and network pharmacology to identify how Sophora flavescens Alt.  The results show that the use of network pharmacology can increase the accuracy and specificity of our predictions for the molecules targeted by insecticides. 
network pharmacology
The stability and reliability of target proteins was analyzed using molecular docking and molecular dynamic simulations. 
molecular docking
The stability and reliability of target proteins was analyzed using molecular docking and molecular dynamic simulations. 
molecular dynamic simulations