We performed CRISRP-Cas9 lethality screens in two adult glioblastoma (GBM) tumor isolates and five pediatric brain tumor isolates representing atypical teratoid rhabdoid tumors (ATRT), diffuse intrinsic pontine glioma, GBM, and medulloblastoma. 
CRISRP-Cas9
We then integrated the screen results with machine learning-based gene-dependency models generated from data from >900 cancer cell lines.



machine learning-based gene-dependency models