DANCR induces cisplatin resistance of triple-negative breast cancer by KLF5/ p27 signaling.An increasing body of evidence suggest that lncRNAs (long noncoding RNAs) play critical roles in human cancer.  Herein, researchers identified a long non-coding RNA DANCR, which promotes cisplatin chemoresistance in triple-negative breast cancer cells.  Mechanistically, DANCR could bind to Krüppel-like factor 5 (KLF5) and induce acetylation of KLF5 at lysine 369 (K369), and DANCR knockdown resulted in downregulation of KLF5 protein levels.  Furthermore, researchers found that the DANCR/KLF5 signaling pathway induced hypersensitivity to cisplatin in chemoresistant patients by inhibiting p27 transcription.  In a nutshell, researcher 's study reinforces the potential presence of a growth regulatory network found in triple negative breast cancer cells and a DANCR/KLF5/p27 signaling pathway was documented in the present study that mediates cisplatin chemoresistant in triple-negative breast cancer.
DANCR
Furthermore, researchers found that the DANCR/KLF5 signaling pathway induced hypersensitivity to cisplatin in chemoresistant patients by inhibiting p27 transcription. 
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