Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.Astrocytes display extraordinary morphological complexity that is essential to support brain circuit development and function.  Here, we show that loss of the formin protein Daam2 in astrocytes increases morphological complexity in the cortex and olfactory bulb, but elicits opposing effects on astrocytic calcium dynamics.  Proteomic profiling and immunoprecipitation experiments identify Slc4a4 as a binding partner of Daam2 in the cortex, and combined deletion of Daam2 and Slc4a4 restores the morphological alterations seen in Daam2 mutants. 
Daam2
Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.Astrocytes display extraordinary morphological complexity that is essential to support brain circuit development and function.  Here, we show that loss of the formin protein Daam2 in astrocytes increases morphological complexity in the cortex and olfactory bulb, but elicits opposing effects on astrocytic calcium dynamics.  Proteomic profiling and immunoprecipitation experiments identify Slc4a4 as a binding partner of Daam2 in the cortex, and combined deletion of Daam2 and Slc4a4 restores the morphological alterations seen in Daam2 mutants. 
Daam2
Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.Astrocytes display extraordinary morphological complexity that is essential to support brain circuit development and function.  Here, we show that loss of the formin protein Daam2 in astrocytes increases morphological complexity in the cortex and olfactory bulb, but elicits opposing effects on astrocytic calcium dynamics.  Proteomic profiling and immunoprecipitation experiments identify Slc4a4 as a binding partner of Daam2 in the cortex, and combined deletion of Daam2 and Slc4a4 restores the morphological alterations seen in Daam2 mutants. 
Daam2
Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.Astrocytes display extraordinary morphological complexity that is essential to support brain circuit development and function.  Here, we show that loss of the formin protein Daam2 in astrocytes increases morphological complexity in the cortex and olfactory bulb, but elicits opposing effects on astrocytic calcium dynamics.  Proteomic profiling and immunoprecipitation experiments identify Slc4a4 as a binding partner of Daam2 in the cortex, and combined deletion of Daam2 and Slc4a4 restores the morphological alterations seen in Daam2 mutants. 
Daam2
Regional heterogeneity of astrocyte morphogenesis dictated by the formin protein, Daam2, modifies circuit function.Astrocytes display extraordinary morphological complexity that is essential to support brain circuit development and function.  Here, we show that loss of the formin protein Daam2 in astrocytes increases morphological complexity in the cortex and olfactory bulb, but elicits opposing effects on astrocytic calcium dynamics.  Proteomic profiling and immunoprecipitation experiments identify Slc4a4 as a binding partner of Daam2 in the cortex, and combined deletion of Daam2 and Slc4a4 restores the morphological alterations seen in Daam2 mutants. 
Daam2