Vertical sleeve gastrectomy-derived gut metabolite licoricidin activates beige fat thermogenesis to combat obesity.Obesity is a chronic metabolic disease, affecting individuals throughout the world.  Results: VSG in mice greatly increased thermogenic gene expression in beige fat, which was correlated with increased energy expenditure.  Licoricidin treatment promoted thermogenic gene expression in beige fat by activating the Adrb3-cAMP-PKA signaling pathway, leading to reduced body weight gain in HFD-fed mice. 
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