The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.Guanosine deaminase (GSDA) in plants specifically deaminates (de)guanosine to produce xanthosine with high specificity, which is further converted to xanthine, a key intermediate in purine metabolism and nitrogen recycling.  We solved GSDA's structures from Arabidopsis thaliana in the free and ligand-bound forms at high resolutions. 
GSDA
The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.Guanosine deaminase (GSDA) in plants specifically deaminates (de)guanosine to produce xanthosine with high specificity, which is further converted to xanthine, a key intermediate in purine metabolism and nitrogen recycling.  We solved GSDA's structures from Arabidopsis thaliana in the free and ligand-bound forms at high resolutions. 
GSDA
Unlike GDA, the enzyme employs a single-proton shuttle mechanism for catalysis and both the substrate and enzyme undergo structural rearrangements. 
GDA
The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis.Guanosine deaminase (GSDA) in plants specifically deaminates (de)guanosine to produce xanthosine with high specificity, which is further converted to xanthine, a key intermediate in purine metabolism and nitrogen recycling.  We solved GSDA's structures from Arabidopsis thaliana in the free and ligand-bound forms at high resolutions. 
GSDA