Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302.  PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity.  Topical application of PXS-6302 after injury also significantly improves scar appearance without reducing tissue strength in porcine injury models.  PXS-6302 therefore represents a promising therapeutic to ameliorate scar formation, with potentially broader applications in other fibrotic diseases.
PXS-6302
Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302.  PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity.  Topical application of PXS-6302 after injury also significantly improves scar appearance without reducing tissue strength in porcine injury models.  PXS-6302 therefore represents a promising therapeutic to ameliorate scar formation, with potentially broader applications in other fibrotic diseases.
PXS-6302
Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302.  PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity.  Topical application of PXS-6302 after injury also significantly improves scar appearance without reducing tissue strength in porcine injury models.  PXS-6302 therefore represents a promising therapeutic to ameliorate scar formation, with potentially broader applications in other fibrotic diseases.
PXS-6302