CONDISOX- continued versus discontinued oxytocin stimulation of induced labour in a double-blind randomised controlled trial.BACKGROUND
 CONDISOX is a double-blind multicentre randomised controlled trial conducted at Danish and Dutch Departments of Obstetrics and Gynaecology.  The CONDISOX trial includes women at a gestational age of 37-42 complete weeks of pregnancy, who have uterine activity stimulated with oxytocin infusion for the induction of labour. 
CONDISOX
CONDISOX- continued versus discontinued oxytocin stimulation of induced labour in a double-blind randomised controlled trial.BACKGROUND

double-blind randomised controlled trial
CONDISOX- continued versus discontinued oxytocin stimulation of induced labour in a double-blind randomised controlled trial.BACKGROUND
 The objective is to investigate how the caesarean section rate is affected when oxytocin stimulation is discontinued in the active phase of labour compared to labours where oxytocin is continued.


 Women are stratified by birth site, indication for oxytocin stimulation (induction of labour, prelabour rupture of membranes) and parity (nulliparous, parous +/- previous caesarean section). 
oxytocin stimulation
The objective is to investigate how the caesarean section rate is affected when oxytocin stimulation is discontinued in the active phase of labour compared to labours where oxytocin is continued.


 Based on a clinically relevant relative reduction in caesarean section rate of 7%, an alpha of 0.05, a beta of 80%, we aim for 1200 participating women (600 in each arm).  We will compare the primary outcome, caesarean section rate, in the two groups using a chi-square test with a p-value of 0.05. 
caesarean section rate
Oxytocin is an effective drug for induction of labour, but is associated with serious adverse effects of which uterine tachysystole, fetal distress and the need of immediate delivery are the most common.  Secondary outcomes include duration of the active phase of labour, incidence of uterine tachysystole, postpartum haemorrhage, admission to the neonatal intensive care unit, Apgar score, umbilical arterial blood pH, and birth experience.



uterine tachysystole
Oxytocin is an effective drug for induction of labour, but is associated with serious adverse effects of which uterine tachysystole, fetal distress and the need of immediate delivery are the most common. 
fetal distress
Oxytocin is an effective drug for induction of labour, but is associated with serious adverse effects of which uterine tachysystole, fetal distress and the need of immediate delivery are the most common. 
immediate delivery