In Vivo Analysis of Dendritic Cell Clonality.Confocal fluorescence microscopy is commonly used for the analysis of tissue architecture and cell distribution (Paddock, Confocal microscopy: methods and protocols. Methods in molecular biology. Humana Press, New York, pp 1-388, 2013). 
Confocal microscopy
When combined with multicolor fate mapping of cell precursors, it allows for analysis of single-color cell clusters, which in turn informs on the clonal relationship of cells in tissues (Snippert et al, Cell 143:134-144. https://doi.org/10.1016/j.cell.2010.09.016 , 2010).  In this chapter, I describe a multicolor fate mapping mouse model and microscopy technique to trace the progeny of conventional dendritic cell (cDC, (Cabeza-Cabrerizo et al, Annu Rev Immunol 39:131. https://doi.org/10.1146/annurev-immunol-061020-053707 , 2021)) progenitors in different tissues and analyze cDC clonality. 
multicolor fate mapping
In Vivo Analysis of Dendritic Cell Clonality.Confocal fluorescence microscopy is commonly used for the analysis of tissue architecture and cell distribution (Paddock, Confocal microscopy: methods and protocols. Methods in molecular biology. Humana Press, New York, pp 1-388, 2013). 
Confocal fluorescence microscopy
In Vivo Analysis of Dendritic Cell Clonality.Confocal fluorescence microscopy is commonly used for the analysis of tissue architecture and cell distribution (Paddock, Confocal microscopy: methods and protocols. Methods in molecular biology. Humana Press, New York, pp 1-388, 2013). 
Confocal microscopy