We performed single-cell RNA sequencing of a total of 247,520 cells and identified cluster-specific molecular signatures. 
single-cell RNA sequencing
Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma.To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organoids and compared with those from healthy individuals. 
induced pluripotent stem cells (iPSCs)
Retinal ganglion cell-specific genetic regulation in primary open-angle glaucoma.To assess the transcriptomic profile of disease-specific cell populations, fibroblasts from patients with primary open-angle glaucoma (POAG) were reprogrammed into induced pluripotent stem cells (iPSCs) before being differentiated into retinal organoids and compared with those from healthy individuals. 
retinal organoids