Exploring the analytical power of the QTOF MS platform to assess monoclonal antibodies quality attributes.The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market. 
QTOF MS
Exploring the analytical power of the QTOF MS platform to assess monoclonal antibodies quality attributes.The biopharmaceutical industry is growing at a fast pace, making nowadays 20% of the pharma market.  Thus, a comprehensive characterization at the molecular level of antibodies heterogeneity such as glycoforms, post-translational modifications (PTMs) and sequence variations is of utmost importance.  Mass spectrometry (MS)-based approaches are undoubtedly the most powerful analytical strategies to monitor and define an array of critical quality attributes on mAbs.  In this work, we demonstrate the analytical power of the Q-TOF MS platform for comprehensive and detailed analysis at molecular levels of an in-house produced mAb. 
MS