Photostability Highly Improved Nanoparticles Based on IR-780 and Negative Charged Copolymer for Enhanced Photothermal Therapy.The development of near-infrared (NIR) dyes with desirable photophysical characteristics for tumor therapy is highly expected at present.  The encapsulation of IR-780 indicated no influence on its original physicochemical property, showing good optical and thermal characteristics.  In addition, the phototoxicity generated by photothermal and photodynamic effect of IR-780@TBMPA under 808 nm laser irradiation was also investigated by reactive oxygen species (ROS) detection and flow cytometry.  Furthermore, the superior accumulation of IR-780@TBMPA in tumor tissues provided sufficient hyperthermia to kill tumor cells, indicating its potential in cancer clinical therapy.
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