TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity.  An increased number of experimental results indicate the implication of TRPM8 channels in cold thermal transduction and pain detection, transmission, and maintenance in different tissues and organs.  This compendium firstly covers newly described papers on the expression of TRPM8 channels and their correlation with pathological states.  An overview on the structural knowledge, after cryo-electron microscopy success in solving different TRPM8 structures, as well as some insights obtained from mutagenesis studies, will follow.  Most recently described families of TRPM8 modulators are also covered, along with a section of molecules that have reached clinical trials.  To finalize, authors provide an outline of the potential prospects in the TRPM8 field.
TRPM8
TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity.  An increased number of experimental results indicate the implication of TRPM8 channels in cold thermal transduction and pain detection, transmission, and maintenance in different tissues and organs.  This compendium firstly covers newly described papers on the expression of TRPM8 channels and their correlation with pathological states. 
TRPM8 Channels
TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.The transient receptor potential melastatin subtype 8 (TRPM8) is a cold sensor in humans, activated by low temperatures (>10, <28 °C), but also a polymodal ion channel, stimulated by voltage, pressure, cooling compounds (menthol, icilin), and hyperosmolarity.  An increased number of experimental results indicate the implication of TRPM8 channels in cold thermal transduction and pain detection, transmission, and maintenance in different tissues and organs.  This compendium firstly covers newly described papers on the expression of TRPM8 channels and their correlation with pathological states.  An overview on the structural knowledge, after cryo-electron microscopy success in solving different TRPM8 structures, as well as some insights obtained from mutagenesis studies, will follow.  Most recently described families of TRPM8 modulators are also covered, along with a section of molecules that have reached clinical trials.  To finalize, authors provide an outline of the potential prospects in the TRPM8 field.
TRPM8