STXBP1 forms amyloid-like aggregates in rat brain and demonstrates amyloid properties in bacterial expression system.Amyloids are the fibrillar protein aggregates with cross-β structure.  One of the identified proteins was STXBP1 taking part in vesicular transport and neurotransmitter secretion.  Using SDD-AGE and protein fractionation we found out that STXBP1 forms small detergent-insoluble aggregates in rat brain.  With immunoprecipitation analysis and C-DAG system, we showed that STXBP1 forms amyloid-like fibrils.  Thus, STXBP1 demonstrates amyloid properties in rat brain and in bacterial expression system.
STXBP1
Using SDD-AGE and protein fractionation we found out that STXBP1 forms small detergent-insoluble aggregates in rat brain. 
SDD-AGE
With immunoprecipitation analysis and C-DAG system, we showed that STXBP1 forms amyloid-like fibrils. 
C-DAG