Evaluation of kojic acid production in a repeated-batch PCS biofilm reactor.In this study, kojic acid, a secondary metabolite as an industrially important compound, was produced by Aspergillus oryzae (A. oryzae), which was immobilized in plastic composite support (PCS) bioreactor.  Nitrogen deficient medium was applied to increase the production of KA in PCS-immobilized bioreactor.  After three cycles of cultivation, 83.47 g/L of KA was produced in PCS bioreactor in nitrogen deficient medium with productivity of 3.09 g/L/d, which is higher than free suspension culture in batch fermentation.  PCS immobilized fermentation system, which allowed a repeated-batch fermentation with higher production and productivity, is a potential tool in industrial production of KA.
PCS
Evaluation of kojic acid production in a repeated-batch PCS biofilm reactor.In this study, kojic acid, a secondary metabolite as an industrially important compound, was produced by Aspergillus oryzae (A. oryzae), which was immobilized in plastic composite support (PCS) bioreactor.  Nitrogen deficient medium was applied to increase the production of KA in PCS-immobilized bioreactor.  After three cycles of cultivation, 83.47 g/L of KA was produced in PCS bioreactor in nitrogen deficient medium with productivity of 3.09 g/L/d, which is higher than free suspension culture in batch fermentation.  PCS immobilized fermentation system, which allowed a repeated-batch fermentation with higher production and productivity, is a potential tool in industrial production of KA.
PCS