Meta-Analysis of Randomized Control Trials Comparing Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Significant Left Main Coronary Narrowing.Previous meta-analyses showed that drug-eluting stent (DES) implantation may serve as an alternative to coronary artery bypass grafting (CABG) for unprotected left main coronary artery (ULMCA) stenosis, largely driven by data from registries.  Hence, we performed a meta-analysis of randomized controlled trials (RCTs) to overcome this limitation.  This meta-analysis included 5 RCTs, totaling 4,595 patients with ULMCA disease. 
Meta-Analysis
PubMed, the Cochrane Library, and Scopus were systematically searched through October 2016 to identify eligible RCTs. 
PubMed
PubMed, the Cochrane Library, and Scopus were systematically searched through October 2016 to identify eligible RCTs. 
Cochrane Library
PubMed, the Cochrane Library, and Scopus were systematically searched through October 2016 to identify eligible RCTs. 
Scopus
In conclusion, DES stenting and CABG for ULMCA disease yield comparable rates of MACCE at 1-year follow-up; however, CABG is associated with a decreased risk of long-term MACCE compared with DES, exclusively driven by the considerable reduction in revascularization events.
SAS