Feeding Obese Diabetic Mice a Genistein Diet Induces Thermogenic and Metabolic Change.Obesity is associated with elevated plasma levels of glucocorticoids and reduced levels of thyroid hormones, both known to effect food intake and energy expenditure.  Furthermore, tissue specific glucocorticoid metabolism is altered in obesity, increasing insulin resistance and cardiometabolic risk.  This was associated with increases in body temperature and plasma levels of triiodothyronine (T3), suggesting a thermogenic effect. 
THERM