Automatic detection and measurement of viral replication compartments by ellipse adjustment.Viruses employ a variety of strategies to hijack cellular activities through the orchestrated recruitment of macromolecules to specific virus-induced cellular micro-environments. 
ellipse adjustment
Adenoviruses (Ad) and other DNA viruses induce extensive reorganization of the cell nucleus and formation of nuclear Replication Compartments (RCs), where the viral genome is replicated and expressed. 
Adenoviruses (Ad)
The proposed algorithm is non iterative, computationally efficient and is invariant to affine transformations. 
the proposed algorithm