We proposed a new algorithm 'GOExtender' to efficiently identify all the connected gene pairs labeled by the same parent GO terms.  GOExtender is used to predict new GO terms with biological network data, and connect them to the existing GO.  Evaluation tests on biological process and cellular component categories of different GO releases showed that GOExtender can extend new GO terms automatically based on the biological network.  Furthermore, we applied GOExtender to the recent release of GO and discovered new GO terms with strong support from literature.


 Software and supplementary document are available at www.msu.edu/%7Ejinchen/GOExtender



GOExtender
We proposed a new algorithm 'GOExtender' to efficiently identify all the connected gene pairs labeled by the same parent GO terms.  GOExtender is used to predict new GO terms with biological network data, and connect them to the existing GO.  Evaluation tests on biological process and cellular component categories of different GO releases showed that GOExtender can extend new GO terms automatically based on the biological network.  Furthermore, we applied GOExtender to the recent release of GO and discovered new GO terms with strong support from literature.


 Software and supplementary document are available at www.msu.edu/%7Ejinchen/GOExtender



GOExtender