Vanilloids selectively sensitize thermal glutamate release from TRPV1 expressing solitary tract afferents.Vanilloids, high temperature, and low pH activate the transient receptor potential vanilloid type 1 (TRPV1) receptor.  In spinal dorsal root ganglia, co-activation of one of these gating sites on TRPV1 sensitized receptor gating by other modes.  Such thermal responses were larger in 150 pM RTX, while the ST-EPSCs remained unaffected.  Vanilloid sensitization of thermal responses persisted in TTX but was blocked by the TRPV1 antagonist capsazepine. 
THERM