Comparing single-agent with doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2: a meta-analysis.AIM
 This systematic review and meta-analysis was performed to assess the efficacy and side effects between single-agent and doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2 (PS2).


 We searched for randomized controlled trials in online electronic databases and extracted data from eligible studies for meta-analysis. 
Meta-analysis
We searched for randomized controlled trials in online electronic databases and extracted data from eligible studies for meta-analysis. 
Randomized controlled trials
We searched for randomized controlled trials in online electronic databases and extracted data from eligible studies for meta-analysis. 
Electronic databases
Pooled hazard ratio (HR) for overall survival (OS), pooled risk difference (RD) for 1-year survival, pooled risk ratio (RR) for objective response rate (ORR) and adverse effects were calculated using a fixed-effect model.



Fixed-effect model