Early detection of virus infection in live human cells using Raman spectroscopy.Virus infection of a human cell was determined only 3 h after invagination. 
Raman spectroscopy
We used viral vector Ad-CMV-control (AdC), which lacks the E1 gene coding for early polypeptide 1 (E1). 
Ad-CMV-control (AdC)
According to partial least-square regression discriminant analysis, it was assumed that two kinds of reaction take place in the cell during viral invasion. 
partial least-square regression discriminant analysis