An ultra-high performance liquid chromatography/mass spectrometry based metabolomics approach was utilized to unveil the global metabolic response to chronic arsenic exposure in rats. 
ultra-high performance liquid chromatography/mass spectrometry
In this study, male Sprague Dawley rats were exposed to 0.5, 2 or 10 ppm sodium arsenite for three months.  Eighteen differential metabolites were identified, and most of them showed dose-dependent responses to arsenic exposure. 
MS