P300 and neuropsychological measurements in patients with schizophrenia and their healthy biological siblings.BACKGROUND
 Patients with schizophrenia and their first-degree relatives' exhibit abnormalities in neuropsychological and electrophysiological measures especially P300.  The aim was to study the P300 and neuropsychological measures together in patients with schizophrenia, their unaffected siblings, and normal controls.


 All subjects were administered P300 event-related potential, which was measured using oddball paradigm and specific neuropsychological tests from NIMHANS neuropsychiatry battery.


 Both patients with schizophrenia and their unaffected biological siblings showed lower P300 amplitude and longer P300 latency when compared with the normal controls.  Patients with schizophrenia and their unaffected biological siblings show deficits in both cognitive function tests and P300 event-related potential. 
P300
All subjects were administered P300 event-related potential, which was measured using oddball paradigm and specific neuropsychological tests from NIMHANS neuropsychiatry battery.



NIMHANS neuropsychiatry battery