PROPER: global protein interaction network alignment through percolation matching.BACKGROUND
 In this paper, we introduce a new global network alignment algorithm for PPI networks called PROPER.  We show that the PROPER algorithm can detect large portions of conserved biological pathways between species.  Also, using a simple parsimonious evolutionary model, we explain why PROPER performs well based on several different comparison criteria.


 We highlight that PROPER has high potential in further applications such as detecting biological pathways, finding protein complexes and PPI prediction.  The PROPER algorithm is available at http://proper.epfl.ch .
PROPER
PROPER: global protein interaction network alignment through percolation matching.BACKGROUND
 In this paper, we introduce a new global network alignment algorithm for PPI networks called PROPER.  We show that the PROPER algorithm can detect large portions of conserved biological pathways between species.  Also, using a simple parsimonious evolutionary model, we explain why PROPER performs well based on several different comparison criteria.


 We highlight that PROPER has high potential in further applications such as detecting biological pathways, finding protein complexes and PPI prediction.  The PROPER algorithm is available at http://proper.epfl.ch .
PROPER