We use molecular dynamics simulations to study the nature of interactions between the side chain pairs ALA-PHE, SER-ASN, and LYS-GLU in bulk water and in water-filled nanopores. 
molecular dynamics simulations
The temperature dependence of the bulk solvent potentials of mean force and the interaction free energies in cylindrical and spherical nanopores is used to identify the corresponding entropic and enthalpic components. 
The temperature dependence of the bulk solvent potentials of mean force and the interaction free energies in cylindrical and spherical nanopores