CML in Chronic Phase with Novel Secondary Cytogenetic Abnormalities: A Case Report.The clonal evolution in t(9;22)-positive Chronic Myelocytic Leukemia (CML) patients is well established.  Here, we present a case with CML-Chronic phase (CML-CP) and novel t(9;13)(q34;q12~13) in addition to t(9;22)(q34;q11.2).  Further studies are required to ascertain the expression of genes that play a role in CML-blast crisis in order to to explore its therapeutic significance and prognostic value.
CML
Fluorescence in situ hybridization (FISH) using dual color dual fusion probe analysis on interphase and metaphase cells confirmed the t(9;13)(q34;q12~13) as clonal evolution and secondary event to Philadelphia chromosome. 
FISH