A total of 12 SNPs in the ESR1, ESR2, FSHR, CYP19A1, SHBG and NRIP1 genes were genotyped in 142 migraine cases and 141 nonmigraine controls, using a BioMark 96.96 dynamic array system. 
BioMark 96.96 dynamic array system
In addition, gene-gene interactions were analysed using generalized multifactor dimensionality reduction (GMDR) methods. 
generalized multifactor dimensionality reduction (GMDR) methods