CT imaging and spontaneous behavior analysis after osmotic blood-brain barrier opening in Wistar rat.In our previous experiments we demonstrated that osmotic opening of the blood brain barrier (BBB) in rats by administration of mannitol into the internal carotid artery leads to cerebral edema. 
CT imaging
Brain edema was verified by computer tomography (CT) examination of the brain and SLA was observed during open field test. 
computer tomography