[IDH1- and IDH2-mutations in brain glial tumors - the new antioncogenic mechanism]. Mutant forms of the gene IDH1 progress significantly slower, have a lower risk of neoplastic transformation, and generally, mutations of this gene have a pronounced anti-oncogenic effect.  IDH1 gene mutations is a complex multi-layered process, which is a completely new, not previously described anti-oncogene activation mechanism of intracellular protection.  A completely new mechanism of antitumor protection has been described - stereotypical IDH1 gene mutation is a gene, in fact, is a key event, causing a cascade of further anti-oncogenic mechanisms in brain gliomas.
IDH1
[IDH1- and IDH2-mutations in brain glial tumors - the new antioncogenic mechanism].
IDH2