DIGRE: Drug-Induced Genomic Residual Effect Model for Successful Prediction of Multidrug Effects.Multidrug regimens are a promising strategy for improving therapeutic efficacy and reducing side effects, especially for complex disorders such as cancer.  We herein present a novel computational approach-Drug-Induced Genomic Residual Effect (DIGRE) Computational Model-to predict drug combination effects by explicitly modeling drug response curves and gene expression changes after drug treatments.  The prediction performance of DIGRE was evaluated using two datasets: 
DIGRE