Kismet positively regulates glutamate receptor localization and synaptic transmission at the Drosophila neuromuscular junction.The Drosophila neuromuscular junction (NMJ) is a glutamatergic synapse that is structurally and functionally similar to mammalian glutamatergic synapses.  The chromodomain helicase DNA binding (CHD) protein, Kismet (Kis), is expressed in both motor neuron nuclei and postsynaptic muscle nuclei of the Drosophila larvae. 
Kismet
Kis is the homolog to human CHD7, which is mutated in CHARGE syndrome. 
CHD7
Kis is the homolog to human CHD7, which is mutated in CHARGE syndrome.  Thus, our data suggest novel avenues of investigation for synaptic defects associated with CHARGE syndrome.
CHARGE syndrome