MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Previous studies have shown that microRNAs play essential roles in cancer growth and progression.  In this study, we evaluated the miR-522s role in cell proliferation in GBM.  Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs).  In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.  We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays.  Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.
MiR-522
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Previous studies have shown that microRNAs play essential roles in cancer growth and progression.  In this study, we evaluated the miR-522s role in cell proliferation in GBM.  Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs).  In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.  We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays.  Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.
miR-522
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Previous studies have shown that microRNAs play essential roles in cancer growth and progression.  We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays. 
PHLPP1
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Previous studies have shown that microRNAs play essential roles in cancer growth and progression.  In this study, we evaluated the miR-522s role in cell proliferation in GBM.  Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs).  In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.  We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays.  Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.
miR-522
Although a number of microRNAs were differentially expressed in glioblastoma (GBM).  In this study, we evaluated the miR-522s role in cell proliferation in GBM.  Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs).  In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.  Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.
GBM
MiR-522 contributes to cell proliferation of human glioblastoma cells by suppressing PHLPP1 expression.Previous studies have shown that microRNAs play essential roles in cancer growth and progression.  In this study, we evaluated the miR-522s role in cell proliferation in GBM.  Expression of miR-522 is markedly upregulated in GBM tissues and GBM cells compared with the matched non-tumor adjacent brain tissues (TAT) and normal human astrocytes (NHAs).  In functional assays, miR-522 promoted GBM cell proliferation, which could be reversed by inhibitor of miR-522.  We further identified PH domain leucine-rich repeats protein phosphatase-1 (PHLPP1) as a putative target of miR-522, which is likely a main contributor to the promotion of tumor cell growth observed in our assays.  Our results demonstrated that miR-522 promoted tumor cell proliferation and hence may represent a novel therapeutically relevant cellular target to treatment of GBM patients.
miR-522