[TRALI is an overlooked severe complication related to blood transfusion]. Transfusion-related acute lung injury (TRALI) is recognized as the most frequent cause of transfusion-related severe morbidity and mortality.  TRALI is characterized by post-transfusional respiratory distress, hypoxaemia and radiographic verified lung infiltration, in the absence of sign of circulatory overload.  TRALI is predominantly triggered by human leukocyte antigen or human neutrophil antigen (HNA) antibodies from the transfused blood component.  Particularly antibodies against the HNA-3a are involved in severe and fatal TRALI cases.  The serological investigation is important to trace and exclude blood donors with TRALI antibodies.
TRALI