According to the new framework, we have implemented a dynamic protein-ligand binding sites predictor called OSML (On-site model for ligand binding sites prediction).  Computer experiments on 10 different ligand types of three hierarchically organized levels show that OSML outperforms most existing predictors.  OSML web server and datasets are freely available at: http://www.csbio.sjtu.edu.cn/bioinf/OSML/ for academic use.
OSML