However, whether miR‑148a influences the migration and invasion of ovarian cancer cells has remained elusive.  Furthermore, sphingosine‑1‑phosphate receptor 1 (S1PR1), which is upregulated in ovarian cancer tissues and cell lines, was identified as a novel target of miR‑148a in SKOV3 ovarian cancer cells.  Furthermore, overexpression of miR‑148a or inhibition of S1PR1 suppressed SKOV3 cell migration and invasion, while restoration of S1PR1 expression reversed the suppressive effect of miR‑148a upregulation on SKOV3 cell migration and invasion. 
THERM