Optimization of a Nucleic Acids united-RESidue 2-Point model (NARES-2P) with a maximum-likelihood approach.Coarse-grained models are useful tools to investigate the structural and thermodynamic properties of biomolecules.  In this paper, a force field optimization method, which is based on maximum-likelihood fitting of the simulated to the experimental conformational ensembles and least-squares fitting of the simulated to the experimental heat-capacity curves, is applied to optimize the Nucleic Acid united-RESidue 2-point (NARES-2P) model for coarse-grained simulations of nucleic acids recently developed in our laboratory.  The optimized NARES-2P force field reproduces the structural and thermodynamic data of small DNA molecules much better than the original force field.
NARES-2P
Optimization of a Nucleic Acids united-RESidue 2-Point model (NARES-2P) with a maximum-likelihood approach.Coarse-grained models are useful tools to investigate the structural and thermodynamic properties of biomolecules. 
maximum-likelihood approach