Daptomycin-induced Acute Eosinophilic Pneumonia.Acute eosinophilic pneumonia (AEP) is a rare entity, often resulting in respiratory failure and the attended mortality.  Daptomycin-induced AEP results from immune-mediated pulmonary epithelial cell injury.  A 65-year-old male on treatment with intravenous daptomycin for three weeks came to the hospital for worsening dyspnea and acute hypoxemic respiratory failure.  Daptomycin was discontinued, and the patient was started on steroid therapy. 
daptomycin
Computerized tomography (CT) of the chest was done, revealing bilateral pulmonary infiltrates.  The bacterial, fungal, viral, and mycobacterial cultures were all negative.  Commonly used diagnostic criteria for AEP using more than 25% of pulmonary eosinophilia should be tailored to patient-related factors.
CT
He underwent bronchoscopy that showed predominant pulmonary eosinophilia. 
bronchoscopy