Cu(II)-Based Paramagnetic Probe to Study RNA-Protein Interactions by NMR.Paramagnetic NMR techniques allow for studying three-dimensional structures of RNA-protein complexes.  For PRE NMR experiments, oligonucleotides are typically spin-labeled using nitroxide reagents.  NMR experiments showed attenuation of signal intensities from protein residues localized in proximity to the paramagnetic probe as the result of RNA-protein interactions. 
NMR