The experimental power of FR900359 to study Gq-regulated biological processes.Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge.  Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. 
FR900359
The experimental power of FR900359 to study Gq-regulated biological processes.Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge.  Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. 
FR900359
The experimental power of FR900359 to study Gq-regulated biological processes.Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge.  Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited to this task. 
FR900359