Target-responsive, DNA nanostructure-based E-DNA sensor for microRNA analysis.Because of the short size and low abundance of microRNAs, it is challenging to develop fast, inexpensive, and simple biosensors to detect them.  In this work, we have demonstrated a new generation (the third generation) of E-DNA sensor for the sensitive and specific detection of microRNAs.  Our third generation of E-DNA sensor can sensitively detect microRNA target (microRNA-141) as low as 1 fM.  The combination of these effects improves the sensitivity of the E-DNA sensor and makes it suitable to the microRNA detection.  Finally, our third generation of E-DNA sensor is generalizable to the detection of other micro RNA targets (for example, microRNA-21).
E-DNA sensor
Target-responsive, DNA nanostructure-based E-DNA sensor for microRNA analysis.Because of the short size and low abundance of microRNAs, it is challenging to develop fast, inexpensive, and simple biosensors to detect them.  In this work, we have demonstrated a new generation (the third generation) of E-DNA sensor for the sensitive and specific detection of microRNAs.  Our third generation of E-DNA sensor can sensitively detect microRNA target (microRNA-141) as low as 1 fM.  The combination of these effects improves the sensitivity of the E-DNA sensor and makes it suitable to the microRNA detection.  Finally, our third generation of E-DNA sensor is generalizable to the detection of other micro RNA targets (for example, microRNA-21).
E-DNA sensor
Target-responsive, DNA nanostructure-based E-DNA sensor for microRNA analysis.Because of the short size and low abundance of microRNAs, it is challenging to develop fast, inexpensive, and simple biosensors to detect them.  In this work, we have demonstrated a new generation (the third generation) of E-DNA sensor for the sensitive and specific detection of microRNAs.  Our third generation of E-DNA sensor can sensitively detect microRNA target (microRNA-141) as low as 1 fM.  The combination of these effects improves the sensitivity of the E-DNA sensor and makes it suitable to the microRNA detection.  Finally, our third generation of E-DNA sensor is generalizable to the detection of other micro RNA targets (for example, microRNA-21).
E-DNA sensor