Brimonidine Toxicity Secondary to Topical Use for an Ulcerated Hemangioma.Combigan (Allergan, Irvine, CA) is an ophthalmic solution that combines 0.2% brimonidine, a selective α-2 adrenergic agonist, with 0.5% timolol, a nonselective β-adrenergic antagonist.  There have been recent reports of successful treatment of superficial infantile hemangiomas (IHs) using Combigan topically. 
Combigan