A randomized trial of normothermic preservation in liver transplantation.Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs.  Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing.  Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. 
THERM