ADCY7 supports development of acute myeloid leukemia.Acute myeloid leukemia (AML) is the most common adult acute leukemia.  In silico analysis of several available databases of AML patients showed that the expression of adenylate cyclase 7 (ADCY7) significantly inversely correlates with the overall survival of AML patients.  To determine whether ADCY7 supports AML development, we employed an shRNA-encoding lentivirus system to inhibit adcy7 expression in human AML cells including U937, MV4-11, and THP-1 cells.  The ADCY7 deficiency resulted in decreased cell growth, elevated apoptosis, and lower c-Myc expression of these leukemia cells.  Our study suggests that inhibition of ADCY7 may be novel strategy for treating leukemia.
ADCY7
To determine whether ADCY7 supports AML development, we employed an shRNA-encoding lentivirus system to inhibit adcy7 expression in human AML cells including U937, MV4-11, and THP-1 cells. 
shRNA-encoding lentivirus system