SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors.  SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.  In mouse embryonic fibroblasts (MEFs), Sirt6 knockout (KO) increased R-Ras2 lysine fatty acylation.  Our study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras family of GTPases and provides an important mechanism by which SIRT6 functions as a tumor suppressor.
SIRT6
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors.  SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.  In mouse embryonic fibroblasts (MEFs), Sirt6 knockout (KO) increased R-Ras2 lysine fatty acylation.  Our study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras family of GTPases and provides an important mechanism by which SIRT6 functions as a tumor suppressor.
SIRT6
In mouse embryonic fibroblasts (MEFs), Sirt6 knockout (KO) increased R-Ras2 lysine fatty acylation. 
Sirt6 knockout (KO)
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation.The Ras family of GTPases are important in cell signaling and frequently mutated in human tumors.  SIRT6, a sirtuin with established tumor suppressor function, regulates the lysine fatty acylation of R-Ras2.  In mouse embryonic fibroblasts (MEFs), Sirt6 knockout (KO) increased R-Ras2 lysine fatty acylation.  Our study establishes lysine fatty acylation as a previously unknown mechanism that regulates the Ras family of GTPases and provides an important mechanism by which SIRT6 functions as a tumor suppressor.
SIRT6