Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers.BACKGROUND

Genomic and transcriptomic hallmarks
While TERT promoter mutations were rare and subclonal in PTCs, they were clonal and highly prevalent in advanced cancers. 
TERT promoter mutations
Application of the TCGA-derived BRAF-RAS score (a measure of MAPK transcriptional output) revealed a preserved relationship with BRAF/RAS mutation in PDTCs, whereas ATCs were BRAF-like irrespective of driver mutation.



BRAF-RAS score
Application of the TCGA-derived BRAF-RAS score (a measure of MAPK transcriptional output) revealed a preserved relationship with BRAF/RAS mutation in PDTCs, whereas ATCs were BRAF-like irrespective of driver mutation.



MAPK transcriptional output