Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality of patients with left ventricular (LV) systolic dysfunction and intra-ventricular conduction delay.  Multisite pacing (MSP), by stimulating the myocardium from more than one locations, is a potential therapeutic option in patients requiring CRT.  Newer devices and expanding knowledge are expected to facilitate the more widespread implementation of MSP and the assessment of its effects in the clinical outcomes of CRT.
CRT
Multisite pacing (MSP), by stimulating the myocardium from more than one locations, is a potential therapeutic option in patients requiring CRT.  This article provides a current update in the methods and outcomes of MSP, as well as in challenges in this field and opportunities for further research and development.


 MSP can be delivered either with multiple leads or with quadripolar LV leads which can stimulate the LV from two separate sites.  Larger patient subgroups and longer follow-up duration are required for more conclusive evaluation of MSP.  Routine use of MSP in clinical practice cannot be advocated at present.  In selected patient subgroups, however, MSP could be considered.  Newer devices and expanding knowledge are expected to facilitate the more widespread implementation of MSP and the assessment of its effects in the clinical outcomes of CRT.
MSP
Cardiac resynchronization therapy (CRT) reduces the morbidity and mortality of patients with left ventricular (LV) systolic dysfunction and intra-ventricular conduction delay.  Multisite pacing (MSP), by stimulating the myocardium from more than one locations, is a potential therapeutic option in patients requiring CRT.  Newer devices and expanding knowledge are expected to facilitate the more widespread implementation of MSP and the assessment of its effects in the clinical outcomes of CRT.
CRT
Multisite pacing (MSP), by stimulating the myocardium from more than one locations, is a potential therapeutic option in patients requiring CRT.  This article provides a current update in the methods and outcomes of MSP, as well as in challenges in this field and opportunities for further research and development.


 MSP can be delivered either with multiple leads or with quadripolar LV leads which can stimulate the LV from two separate sites.  Larger patient subgroups and longer follow-up duration are required for more conclusive evaluation of MSP.  Routine use of MSP in clinical practice cannot be advocated at present.  In selected patient subgroups, however, MSP could be considered.  Newer devices and expanding knowledge are expected to facilitate the more widespread implementation of MSP and the assessment of its effects in the clinical outcomes of CRT.
MSP