YAP and the Hippo pathway in pediatric cancer.The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis.  Its principal effectors, YAP and TAZ, regulate signaling by the embryonic stem cells and determine cell fate and histogenesis. 
YAP
YAP and the Hippo pathway in pediatric cancer.The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis.  Emerging studies have shed light on the upregulation of Hippo pathway members in several pediatric cancers and may offer prognostic information on rhabdomyosarcoma, osteosarcoma, Wilms tumor, neuroblastoma, medulloblastoma, and other brain gliomas. 
Hippo pathway
It is evolutionarily conserved in mammals and is stimulated by cell-cell contact, inhibiting cell proliferation in response to increased cell density. 
cell-cell contact
Its principal effectors, YAP and TAZ, regulate signaling by the embryonic stem cells and determine cell fate and histogenesis. 
embryonic stem cells
YAP and the Hippo pathway in pediatric cancer.The Hippo pathway is an important signaling pathway that controls cell proliferation and apoptosis.  Emerging studies have shed light on the upregulation of Hippo pathway members in several pediatric cancers and may offer prognostic information on rhabdomyosarcoma, osteosarcoma, Wilms tumor, neuroblastoma, medulloblastoma, and other brain gliomas. 
pediatric cancer