tRNA--the golden standard in molecular biology.Transfer RNAs (tRNAs) represent a major class of RNA molecules.  The discovery of tRNA in the late 1950's provided critical insight into a genetic machinery when little was known about the central dogma of molecular biology.  In 1965, Robert Holley determined the first nucleotide sequence of alanine transfer RNA (tRNA(Ala)) which earned him the 1968 Nobel Prize in Physiology or Medicine.  Today, tRNA is one of the best described and characterized biological molecules.  Here we review some of the key historical events in tRNA research which led to breakthrough discoveries and new developments in molecular biology.
tRNA
tRNA--the golden standard in molecular biology.Transfer RNAs (tRNAs) represent a major class of RNA molecules.  The discovery of tRNA in the late 1950's provided critical insight into a genetic machinery when little was known about the central dogma of molecular biology.  In 1965, Robert Holley determined the first nucleotide sequence of alanine transfer RNA (tRNA(Ala)) which earned him the 1968 Nobel Prize in Physiology or Medicine.  Today, tRNA is one of the best described and characterized biological molecules.  Here we review some of the key historical events in tRNA research which led to breakthrough discoveries and new developments in molecular biology.
tRNA
tRNA--the golden standard in molecular biology.Transfer RNAs (tRNAs) represent a major class of RNA molecules.  The discovery of tRNA in the late 1950's provided critical insight into a genetic machinery when little was known about the central dogma of molecular biology.  In 1965, Robert Holley determined the first nucleotide sequence of alanine transfer RNA (tRNA(Ala)) which earned him the 1968 Nobel Prize in Physiology or Medicine.  Today, tRNA is one of the best described and characterized biological molecules.  Here we review some of the key historical events in tRNA research which led to breakthrough discoveries and new developments in molecular biology.
tRNA