Translational PK/PD modeling for cardiovascular safety assessment of drug candidates: Methods and examples in drug development.INTRODUCTION
 Drug-induced changes observed in different cardiovascular endpoints (QRS complex and QTc interval of the ECG, heart rate, blood pressure, and myocardial contractility) were described by means of PK/PD modeling.  PK/PD modeling is thus demonstrated as a powerful tool to aid in the quantitative cardiovascular safety assessment of drug candidates and the optimization of early clinical study protocols.
PK/PD modeling