Isothermal microcalorimetry accurately detects bacteria, tumorous microtissues, and parasitic worms in a label-free well-plate assay.Isothermal microcalorimetry is a label-free assay that allows monitoring of enzymatic and metabolic activities.  Here, an isothermal microcalorimeter, equipped with a vessel holder similar to a 48-well plate, was used.  The culture released 2.1J with a maximum thermal power of 76 μW.  Growth of tumor microtissues releasing a maximum thermal power of 2.1 μW was also monitored and corresponds to a diameter increase of the microtissues from ca. 
THERM