The clinical utility of cycle of threshold value of GeneXpert MTB/RIF (CBNAAT) and its diagnostic accuracy in pulmonary and extra-pulmonary samples at a tertiary care center in India.BACKGROUND
 There are knowledge gaps in the in-depth analysis of the most promising and robust diagnostic tool, GeneXpert MTB/RIF (CBNAAT). 
GeneXpert MTB/RIF
The clinical utility of cycle of threshold value of GeneXpert MTB/RIF (CBNAAT) and its diagnostic accuracy in pulmonary and extra-pulmonary samples at a tertiary care center in India.BACKGROUND
 There are knowledge gaps in the in-depth analysis of the most promising and robust diagnostic tool, GeneXpert MTB/RIF (CBNAAT).  The cycle of threshold (CT) value of the CBNAAT test and its clinical implications has not been explored much.


 Sensitivity and specificity of CBNAAT was calculated with culture as the gold standard.  The overall sensitivity of CBNAAT was 88.5%, with bronchial washing specimen being the most sensitive (92.3%) and pleural fluid being the least (66.7%).  In smear negative individuals, the sensitivity of CBNAAT was 80.9%.  The additional yield of CBNAAT over smear microscopy was 10.9%.  CBNAAT is a robust test for accurate diagnosis of tuberculosis both pulmonary and extra-pulmonary, smear negative as well, especially in resource-limited settings. 
CBNAAT