Magnetic fluid hyperthermia enhances cytotoxicity of bortezomib in sensitive and resistant cancer cell lines.The proteasome inhibitor bortezomib (BZ) has shown promising results in some types of cancer, but in others it has had minimal activity.  Recent studies have reported enhanced efficacy of BZ when combined with hyperthermia.  However, the use of magnetic nanoparticles to induce hyperthermia in combination with BZ has not been reported.  This novel hyperthermia modality has shown better potentiation of chemotherapeutics over other types of hyperthermia.  We hypothesized that inducing hyperthermia via magnetic nanoparticles (MFH) would enhance the cytotoxicity of BZ in BZ-sensitive and BZ-resistant cancer cells more effectively than hyperthermia using a hot water bath (HWH).  The results indicate enhanced potentiation between hyperthermic treatment and BZ. 
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