Three different approaches were evaluated, high-performance liquid chromatography coupled to UV detector (HPLC), capillary electrophoresis coupled to UV detector (CE) and a potentiometric multisensor system - electronic tongue (ET).  Most studies involving HPLC and CE separations use these as selective instruments for quantification of individual substances. 
HPLC
Exploring bitterness of traditional Chinese medicine samples by potentiometric electronic tongue and by capillary electrophoresis and liquid chromatography coupled to UV detection.Instrumental bitterness assessment of traditional Chinese herbal medicine (TCM) preparations was addressed in this study.  Three different approaches were evaluated, high-performance liquid chromatography coupled to UV detector (HPLC), capillary electrophoresis coupled to UV detector (CE) and a potentiometric multisensor system - electronic tongue (ET).  Most studies involving HPLC and CE separations use these as selective instruments for quantification of individual substances.  These profiles are somewhat analogous to the profiles produced by the ET. 
CE
Exploring bitterness of traditional Chinese medicine samples by potentiometric electronic tongue and by capillary electrophoresis and liquid chromatography coupled to UV detection.Instrumental bitterness assessment of traditional Chinese herbal medicine (TCM) preparations was addressed in this study.  Three different approaches were evaluated, high-performance liquid chromatography coupled to UV detector (HPLC), capillary electrophoresis coupled to UV detector (CE) and a potentiometric multisensor system - electronic tongue (ET).  Most studies involving HPLC and CE separations use these as selective instruments for quantification of individual substances.  However we employed these techniques to provide chromatographic or electrophoretic sample profiles.  These profiles are somewhat analogous to the profiles produced by the ET.  Profiles from all instruments were then related to professional sensory panel evaluations using projections on latent structures (PLS) regression.  It was found that all three methods allow for bitterness assessment in TCM samples in terms of human sensory panel with root mean squared errors of prediction ca. 
ET