Quantitative Assessment of Thermodynamic Theory in Elucidating the Behavior of Water under Hydrophobic Confinement.A macroscopic thermodynamics-based theory that can quantitatively describe the behavior of water confined between hydrophobic solutes has so far remained elusive.  We have determined free energy profiles of water confined between two nanometer-sized surfaces of varying hydrophobicity using molecular simulations and have estimated thermodynamic properties such as contact angle, line tension, and size of the critical vapor tube from independent simulations.  Exclusion of the line-tension term from thermodynamic theory leads to a qualitative disagreement between theoretical predictions and results from molecular simulations. 
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