PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy.BACKGROUND & AIMS
 The PAGE-B score was developed based on age, gender and platelets (c-index=0.82, 0.81 after bootstrap validation).  The predictability of PAGE-B score was similar (c-index=0.82) in the validation dataset.  Patients with PAGE-B ⩽9, 10-17, ⩾18 had 5-year cumulative HCC incidence rates of 0%, 3%, 17% in the derivation and 0%, 4%, 16% in the validation dataset.


 PAGE-B, which is based only on baseline patients' age, gender and platelets, represents a simple and reliable score for prediction of the 5-year HCC risk in Caucasian CHB patients under entecavir/tenofovir.
PAGE-B
PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy.BACKGROUND & AIMS

PAGE-B predicts the risk of developing hepatocellular carcinoma in Caucasians with chronic hepatitis B on 5-year antiviral therapy.
Using data from eight centers (derivation dataset, n=1325), a HCC risk score was developed based on multivariable Cox models and points system for simplification. 
Cox models
Using data from eight centers (derivation dataset, n=1325), a HCC risk score was developed based on multivariable Cox models and points system for simplification. 
points system for simplification
Harrell's c-index was used as discrimination, bootstrap for internal validation and the data from the 9(th) and largest center (validation dataset, n=490) for external validation.



Harrell's c-index
Harrell's c-index was used as discrimination, bootstrap for internal validation and the data from the 9(th) and largest center (validation dataset, n=490) for external validation.



bootstrap for internal validation
Harrell's c-index was used as discrimination, bootstrap for internal validation and the data from the 9(th) and largest center (validation dataset, n=490) for external validation.



the data from the 9(th) and largest center (validation dataset, n=490)
The PAGE-B score was developed based on age, gender and platelets (c-index=0.82, 0.81 after bootstrap validation). 
the PAGE-B score was developed based on age, gender and platelets (c-index=0.82, 0.81 after bootstrap validation).