Tisseel's impact on hemostasis for 2-3 and 4-6-level lumbar laminectomies.BACKGROUND
 Tisseel (Baxter International Inc., Westlake Village, CA, USA), a fibrin sealant, was originally devised to strengthen repairs of spinal cerebrospinal fluid (CSF) fistulas.  Here, we evaluated how Tisseel correlated with hemostasis (e.g., defined as reduced postoperative drainage, time to drain removal, length of stay (LOS), and postoperative transfusion requirements) in 58 patients undergoing 2-3 vs. 79 patients having 4-6 level lumbar laminectomies.


 We assessed how Tisseel correlated with hemostasis in 58 patients undergoing 2-3 level laminectomies/stenosis (with 48 herniated discs and 20 synovial cysts, 1 degenerative spondylolisthesis) vs. 79 having 4-6 level laminectomies/stenosis (with 39 lumbar discs, 45 synovial cysts, and 26 degenerative spondylolisthesis).


 Utilizing Tisseel as a hemostatic allowed us to quantitate hemostasis (the average postoperative drainage, time to drain removal, LOS, and postoperative transfusion requirements) for those undergoing 2-3 level laminectomies vs. 4-6 level procedures with large subsets also exhibiting herniated discs, synovial cysts, and degenerative spondylolisthesis.
Tisseel
Tisseel (Baxter International Inc., Westlake Village, CA, USA), a fibrin sealant, was originally devised to strengthen repairs of spinal cerebrospinal fluid (CSF) fistulas. 
Baxter International Inc.