Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo.Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. 
CRISPR-Cas9
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo.Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. 
CRISPR-Cas9
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo.Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. 
CRISPR-Cas nucleases
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo.Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. 
CRISPR-Cas9
Remarkably, the same is not true of zinc-finger nucleases (ZFNs), which cleave equally well at nucleosome-occupied and nucleosome-depleted sites. 
ZFNs
Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo.Genome editing with CRISPR-Cas nucleases has been applied successfully to a wide range of cells and organisms. 
CRISPR-Cas9