Locus and gene-based GWAS meta-analysis identifies new diabetic nephropathy genes.Objective Assimilation of SNPs Interacting in Synchrony (OASIS) is a locus-based clustering algorithm recently described that can potentially address false positives and negatives in genome-wide association studies (GWAS) of complex disorders.  OASIS was applied to three DN dbGAP GWAS datasets (4725 subjects; 1.06 million SNPs).  OASIS identified 19 DN genes which were verified using single variant replication in a standard association study and gene-based analysis using GATES.  Hence, composite analysis with OASIS, gene-based, and single variant association testing can be universally applied to existing GWAS datasets for the identification of new genes.
OASIS
OASIS identified 19 DN genes which were verified using single variant replication in a standard association study and gene-based analysis using GATES. 
GATES
CARS and FRMD3 were confirmed as DN genes, and five known diabetes-associated genes, viz. 
CARS