N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model.OBJECTIVE
 The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea.



N-acetylcysteine
N-acetylcysteine Prevents Gentamicin Ototoxicity in a Rat Model.OBJECTIVE
 The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea.


 Gentamicin, gentamicin plus NAC, and NAC alone were intraperitoneally administered for 15 days.  ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation.  The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs.  Gentamicin ototoxicity can be detected by ABR and OAE testing in rats, and NAC may protect the cochlear cells from apoptosis.
gentamicin
The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea.



ABRs
The possible preventive effect of N-acetylcysteine (NAC) in gentamicin ototoxicity was studied with auditory brain stem responses (ABRs), otoacoustic emissions (OAEs), and histopathological investigation of the cochlea.


 ABR thresholds and OAEs were attenuated in the gentamicin group, in which apoptosis was detected with histopathological investigation.  The group that received NAC in addition to gentamicin had better ABR thresholds and better OAEs. 
OAEs