Improving the flux distributions simulated with genome-scale metabolic models of Saccharomyces cerevisiae.Genome-scale metabolic models (GEMs) can be used to evaluate genotype-phenotype relationships and their application to microbial strain engineering is increasing in popularity.  Here, the wild-type simulations of selected GEMs for Saccharomyces cerevisiae have been analysed and most of the models tested predicted erroneous fluxes in central pathways, especially in the pentose phosphate pathway. 
GEMs
However, the accuracy of this reference, when calculated with flux balance analysis, has not been studied in detail before. 
flux balance analysis