The 3D in vitro breast tumor models were simulated using Comsol multiphysics, fabricated using specially designed chips, and treated with doxorubicin-loaded chitosan-coated La0.7Sr0.3MnO3 (DC-LSMO) nanoparticles for hyperthermia and combination therapy in both perfused and non-perfused conditions. 
Comsol multiphysics