Estimation of melting points of large set of persistent organic pollutants utilizing QSPR approach.The presence of polyhalogenated persistent organic pollutants (POPs), such as Cl/Br-substituted benzenes, biphenyls, diphenyl ethers, and naphthalenes has been identified in all environmental compartments.  In this study, we estimated the melting points of a large group (1419 compounds) of chloro- and bromo- derivatives of dibenzo-p-dioxins, dibenzofurans, biphenyls, naphthalenes, diphenylethers, and benzenes by utilizing quantitative structure-property relationship (QSPR) techniques. 
QSPR
The compounds were classified by applying structure-based clustering methods followed by GA-PLS modeling. 
GA-PLS
In addition, random forest method has been applied to develop more general models. 
random forest