Telomerase reverse transcriptase regulates microRNAs.MicroRNAs are small non-coding RNAs that inhibit the translation of target mRNAs.  Here, we report that telomerase reverse transcriptase (TERT) extensively affects the expression levels of mature microRNAs. 
Telomerase reverse transcriptase
In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and DICER, into precursor and mature microRNAs, respectively. 
RNA polymerase II
In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and DICER, into precursor and mature microRNAs, respectively. 
DROSHA
In humans, most microRNAs are transcribed by RNA polymerase II as long primary transcripts and processed by sequential cleavage of the two RNase III enzymes, DROSHA and DICER, into precursor and mature microRNAs, respectively. 
DICER
Similar results were obtained with the suppression of either BRG1 (also called SMARCA4) or nucleostemin, which are proteins interacting with TERT and functioning beyond telomeres. 
BRG1 (also called SMARCA4)
Similar results were obtained with the suppression of either BRG1 (also called SMARCA4) or nucleostemin, which are proteins interacting with TERT and functioning beyond telomeres. 
nucleostemin