TIPE2 attenuates liver fibrosis by reversing the activated hepatic stellate cells.TIPE2, the tumor necrosis factor (TNF)-α-induced protein 8-like 2 (TNFAIP8L2), plays an important role in regulating inflammation and immune homeostasis. 
TIPE2
Functionally, over-expression of TIPE-2 by GV141-TIPE-2 hindered the HSC-T6 cells activation and proliferation and expressions of β-Catenin, Cmyc, Cyclin D1. 
GV141-TIPE-2
However, inhibition TIPE-2 expression by TIPE-2 siRNA showed the opposite effect. 
TIPE-2 siRNA