A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications.  Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes.  We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli.  A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP.  The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP.  Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
THERM
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications.  Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes.  We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli.  A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP.  The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP.  Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
THERM
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications.  Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes.  We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli.  A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP.  The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP.  Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
THERM
A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes.The adipokine adipocyte fatty acid-binding protein (A-FABP) has been implicated in obesity-related cardio-metabolic complications.  Here we show that A-FABP increases thermogenesis by promoting the conversion of T4 to T3 in brown adipocytes.  We find that A-FABP levels are increased in both white (WAT) and brown (BAT) adipose tissues and the bloodstream in response to thermogenic stimuli.  A-FABP knockout mice have reduced thermogenesis and whole-body energy expenditure after cold stress or after feeding a high-fat diet, which can be reversed by infusion of recombinant A-FABP.  The thermogenic responses to T4 are abrogated in A-FABP KO mice, but enhanced by A-FABP.  Thus, A-FABP acts as a physiological stimulator of BAT-mediated adaptive thermogenesis.
THERM