Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains.The objective of this study is to identify sex differentially expressed genes in bone using a mouse model of spontaneous fracture, sfx, which lacks the gene for L-gulonolactone oxidase (Gulo), a key enzyme in the ascorbic acid (AA) synthesis pathway.  We first identified the genes that are differentially expressed in the femur between female and male in sfx mice.  Our result indicated that there was a sex difference in the whole genome profiles in sfx mice as measured by the proportion of up- and downregulated genes.  Several genes in the pathway of bone development are differentially expressed between the male and female of sfx mice. 
sfx
Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains.The objective of this study is to identify sex differentially expressed genes in bone using a mouse model of spontaneous fracture, sfx, which lacks the gene for L-gulonolactone oxidase (Gulo), a key enzyme in the ascorbic acid (AA) synthesis pathway. 
BXD RI strains