Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation.Severe asthma has significant disease burden and results in high healthcare costs.  Mouse models are useful to identify mechanisms underlying disease pathogenesis and for the preclinical assessment of new therapies.  In fact, existing mouse models have contributed significantly to our understanding of allergic/eosinophilic phenotypes of asthma and facilitated the development of novel targeted therapies (e.g. anti-IL-5 and anti-IgE).  No mouse model encompasses all features of severe asthma.  However, mouse models can provide insight into pathogenic pathways that are relevant to severe asthma. 
Mouse
Mouse models of severe asthma: Understanding the mechanisms of steroid resistance, tissue remodelling and disease exacerbation.Severe asthma has significant disease burden and results in high healthcare costs.  Mouse models are useful to identify mechanisms underlying disease pathogenesis and for the preclinical assessment of new therapies.  In fact, existing mouse models have contributed significantly to our understanding of allergic/eosinophilic phenotypes of asthma and facilitated the development of novel targeted therapies (e.g. anti-IL-5 and anti-IgE).  No mouse model encompasses all features of severe asthma.  However, mouse models can provide insight into pathogenic pathways that are relevant to severe asthma. 
mouse