Furthermore, the relation between overexpression of P-glycoprotein (P-gp) and resistant cancers has been well established.  Furthermore, 43 can sensitize Flp-In™-293/MDR cells toward vincristine, paclitaxel and doxorubicin by 17.95-fold, 13.68-fold and 26.43-fold at 2.5 μM, respectively. 
THERM