Assessing Similarity Among Individual Tumor Size Lesion Dynamics: The CICIL Methodology.Mathematical models of tumor dynamics generally omit information on individual target lesions (iTLs), and consider the most important variable to be the sum of tumor sizes (TS).  We called this new methodology ClassIfication Clustering of Individual Lesions (CICIL).  We used CICIL to assess similarities among the TS dynamics of 3,223 iTLs measured in 1,056 patients with metastatic colorectal cancer treated with cetuximab combined with irinotecan, in two phase II studies.  The CICIL methodology has also been implemented in a user-friendly and efficient Java-based framework.
CICIL
The CICIL methodology has also been implemented in a user-friendly and efficient Java-based framework.
Java