Endoscopic mucosal resection (EMR) and endoscopic ultrasound (EUS) are frequently used for staging prior to endoscopic therapy.  Our aims were to evaluate: (1) if endoscopic forceps biopsies correlated with EMR histology in these patients; (2) the utility of EUS compared to EMR; and (3) if accuracy of EUS varied based on grade of differentiation of tumor.


 This is a retrospective review of patients referred to endoscopic therapy of BE with HGD or early esophageal adenocarcinoma (EAC) who underwent EMR from 2006 to 2011.  A total of 151 patients underwent EMR.  In 50 % (75/151) of patients, EMR histology was consistent with endoscopic forceps biopsy findings.  EMR resulted in change in diagnosis with upstaging in 21 % (32/151) and downstaging in 29 % (44/151).  In patients with HGD on EMR, EUS staging was T0 in 74.1 % (23/31) but upstaged in 25.8 % (8/31).  In patients with IMC on EMR, EUS findings were T1a in 23.6 % (9/38), upstaged in 18.4 % (7/38) and downstaged in 57.8 % (22/38).  EUS accurately identified EMR histology in all submucosal cancers.  Grade of differentiation was reported in 24 cancers on EMR histology.  Endoscopic forceps biopsy correlated with EMR findings in only 50 % of patients.  Irrespective of the endoscopic forceps biopsy results, all BE patients with visible lesions should be referred to EMR.
EMR
Endoscopic mucosal resection (EMR) and endoscopic ultrasound (EUS) are frequently used for staging prior to endoscopic therapy.  Our aims were to evaluate: (1) if endoscopic forceps biopsies correlated with EMR histology in these patients; (2) the utility of EUS compared to EMR; and (3) if accuracy of EUS varied based on grade of differentiation of tumor.


 Age, race, sex, length of Barrett's segment, hiatal hernia size, number of endoscopies and biopsy results and EUS findings were abstracted.


 In patients with HGD on EMR, EUS staging was T0 in 74.1 % (23/31) but upstaged in 25.8 % (8/31).  In patients with IMC on EMR, EUS findings were T1a in 23.6 % (9/38), upstaged in 18.4 % (7/38) and downstaged in 57.8 % (22/38).  EUS accurately identified EMR histology in all submucosal cancers.  There was no correlation between grade and EUS staging.


 EUS is of limited utility in accurate staging of BE patients with HGD or early EAC. 
EUS