Sensitive detection of voltage transients using differential intensity surface plasmon resonance system.This paper describes theoretical and experimental study of the fundamentals of using surface plasmon resonance (SPR) for label-free detection of voltage.  Externally-applied voltage leads to changes in the free electron density in the surface of the metal, shifting the SPR position.  The study shows the effects of the applied voltage on the shape of the SPR curve.  The response is presented in a universal term that can be used to assess the voltage sensitivity of different SPR instruments.  Finally, it demonstrates the capacity of the SPR system in resolving dynamic voltage signals; a detection limit of 10mV with a temporal resolution of 5ms is achievable.  These findings pave the way for the use of SPR systems in the detection of electrical activity of biological cells.
SPR
Sensitive detection of voltage transients using differential intensity surface plasmon resonance system.This paper describes theoretical and experimental study of the fundamentals of using surface plasmon resonance (SPR) for label-free detection of voltage.  Externally-applied voltage leads to changes in the free electron density in the surface of the metal, shifting the SPR position.  The study shows the effects of the applied voltage on the shape of the SPR curve.  The response is presented in a universal term that can be used to assess the voltage sensitivity of different SPR instruments.  Finally, it demonstrates the capacity of the SPR system in resolving dynamic voltage signals; a detection limit of 10mV with a temporal resolution of 5ms is achievable.  These findings pave the way for the use of SPR systems in the detection of electrical activity of biological cells.
SPR