[Effects of NVP-BKM120 on the triple-negative breast cancer cell]. To investigatethe effect of NVP-BKM120 on the triple-negative breast cancer cell lines.



NVP-BKM120
Breast cancer cell line MDA-MB-231 and Cal51 were divided into control group and experimental group.  In MDA-MB-231 cell lines, IC50 of BKM120 was (20.01±3.46) µmol/L for SCs and (3.07±0.14) µmol/L for total cells. 
MDA-MB-231
Breast cancer cell line MDA-MB-231 and Cal51 were divided into control group and experimental group. 
Cal51
The inhibitory effects of BKM120 were evaluated by MTT assays. 
MTT assays
The drug effects on CSC population and characteristics were investigated through mammosphere formation assay and colony formation assay. 
mammosphere formation assay
The drug effects on CSC population and characteristics were investigated through mammosphere formation assay and colony formation assay. 
colony formation assay
Western blot was used to observe the expressionof related protein. 
Western blot