Perspective on the Application of Microphysiological Systems to Drug Transporter Studies.Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities.  The development of microphysiological systems that bring simulated physiologic conditions to in vitro cell culture models has enormous potential to better reproduce the morphology and transport activity across several organ models, especially in tissues such as the liver, kidney, intestine, or the blood-brain barrier, in which drug transporters play a key role.  In this short review, we exemplify recent developments in the characterization of perfused microphysiological systems involving the activity of drug transporters. 
Microphysiological Systems
The development of microphysiological systems that bring simulated physiologic conditions to in vitro cell culture models has enormous potential to better reproduce the morphology and transport activity across several organ models, especially in tissues such as the liver, kidney, intestine, or the blood-brain barrier, in which drug transporters play a key role. 
in vitro cell culture models
Perspective on the Application of Microphysiological Systems to Drug Transporter Studies.Transmembrane flux of a drug within a tissue or organ frequently involves a complex system of transporters from multiple families that have redundant and overlapping specificities.  The development of microphysiological systems that bring simulated physiologic conditions to in vitro cell culture models has enormous potential to better reproduce the morphology and transport activity across several organ models, especially in tissues such as the liver, kidney, intestine, or the blood-brain barrier, in which drug transporters play a key role.  In this short review, we exemplify recent developments in the characterization of perfused microphysiological systems involving the activity of drug transporters. 
microphysiological systems