Multimodal intervention in older adults improves resting-state functional connectivity between the medial prefrontal cortex and medial temporal lobe.The prefrontal cortex and medial temporal lobe are particularly vulnerable to the effects of aging.  Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults.  The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default-mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain.  Our results suggest that multimodal intervention could postpone the effects of aging and improve the function of the regions that are most heavily influenced by aging, as well as play an important role in preserving the brain and cognition during old age.
Multimodal intervention
Here, using multimodal intervention training, we investigated the functional plasticity in resting-state connectivity of these two regions in older adults. 
multimodal intervention training
The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default-mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. 
Tai Chi exercise
The multimodal intervention, comprised of cognitive training, Tai Chi exercise, and group counseling, was conducted to explore the regional connectivity changes in the default-mode network, as well as changes in prefrontal-based voxel-wise connectivity in the whole brain. 
group counseling