Delta-pgm, a new live-attenuated vaccine against Brucella suis.Brucellosis is one of the most widespread zoonosis in the world affecting many domestic and wild animals including bovines, goats, pigs and dogs.  The Delta-pgm strain lacks a complete lipopolysaccharide, is unable to synthesize cyclic beta glucans and is sensitive to several detergents and Polymyxin B. We show that this strain replicates in cultured cells, is completely avirulent in the mouse model of infection but protects against a challenge of the virulent strain inducing the production of pro-inflammatory cytokines. 
Delta-pgm
Delta-pgm, a new live-attenuated vaccine against Brucella suis.Brucellosis is one of the most widespread zoonosis in the world affecting many domestic and wild animals including bovines, goats, pigs and dogs.  Each species of the Brucella genus has a particular tropism toward different mammals being the most relevant for human health Brucella abortus, Brucella melitensis and Brucella suis that infect bovines, goats/camelids and swine respectively. 
Brucella suis
Delta-pgm, a new live-attenuated vaccine against Brucella suis.Brucellosis is one of the most widespread zoonosis in the world affecting many domestic and wild animals including bovines, goats, pigs and dogs. 
live-attenuated vaccine
Delta-pgm, a new live-attenuated vaccine against Brucella suis.Brucellosis is one of the most widespread zoonosis in the world affecting many domestic and wild animals including bovines, goats, pigs and dogs.  This novel strain could be an excellent candidate for the control of swine brucellosis, a disease of emerging concern in many parts of the world.
Brucellosis
Although for B. abortus and B. melitensis there are vaccines available, there is no efficient vaccine to protect swine from B. suis infection so far. 
B. abortus
Although for B. abortus and B. melitensis there are vaccines available, there is no efficient vaccine to protect swine from B. suis infection so far. 
B. melitensis
This novel strain could be an excellent candidate for the control of swine brucellosis, a disease of emerging concern in many parts of the world.
swine brucellosis