Answers.Body: <p>You can do functional enrichment analysis, for instance with <code>gProfiler</code> in R and see if your marker genes are enriched in any GO term related with the plasma membrane. </p>
  
  <p>Alternatively, you can generate a list with genes whose product are located at the plasma membrane and perform Gene Set Enrichment Analysis, for instance with <code>fgsea</code> in R.</p>
  
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2019-06-03T07:06:50.777Z
Answers.LastActivityDate: 2019-06-03T07:23:30.197Z
Answers.LastEditDate: 2019-06-03T07:23:30.197Z
Answers.UserDisplayName: jxx_fa
Body: <p>I have a list of cell markers differentially expressed between 2 groups of cells, that I got with the FindMarkers command in Seurat. I want to enrich for those genes that are expressed in the cell membrane. Are there any specific tools/commands I can use to do that? Thanks! </p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2019-06-03T08:32:21.853Z
Comments.Text: Could you explain what do you mean by "enrich" test if some group is differently expressed or retrieve more information about those genes from other sources?
Comments.UserDisplayName: llrs
Tags: <seurat>
Title: Enrich for genes expressed in the plasma membrane
ThreadText: # Enrich for genes expressed in the plasma membrane
  
  (Asked by: username_0 on 2019-06-02)
  
  I have a list of cell markers differentially expressed between 2 groups of cells, that I got with the FindMarkers command in Seurat. I want to enrich for those genes that are expressed in the cell membrane. Are there any specific tools/commands I can use to do that? Thanks!
  
  **Tags:** seurat
  
  > **Comments:**
  > **username_1**: Could you explain what do you mean by "enrich" test if some group is differently expressed or retrieve more information about those genes from other sources?  
  
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  ## 1 answers
  
  ### Answer by username_2 on 2019-06-03. Score: 1
  
  You can do functional enrichment analysis, for instance with `gProfiler` in R and see if your marker genes are enriched in any GO term related with the plasma membrane.
  
  Alternatively, you can generate a list with genes whose product are located at the plasma membrane and perform Gene Set Enrichment Analysis, for instance with `fgsea` in R.
  
  
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