Body: <p>Where/How can I download all proteins in the UniProt with signal peptide annotated? I downloaded the uniref50.xml. However, the annotation information is not contained.</p>
  <p>In an XML record of a protein, the signal peptide information is contained in <code>&lt;feature type=&quot;signal peptide&quot; evidence=&quot;2&quot;&gt; &lt;/feature&gt;</code>. The uniref.xml does not have this information. uniprot annotates this feature with signalp mainly.</p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2023-02-01T02:26:28.040Z
Comments.Text: Please edit the question to limit it to a specific problem with enough detail to identify an adequate answer.
Comments.UserDisplayName: Community
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2023-02-01T17:08:39.300Z
Comments.Text: Do you have a reason to expect that the signal peptide should be annotated there? Can you point us to more information about how uniprot annotates such features?
Comments.UserDisplayName: Maximilian Press
Tags: <uniprot>
Title: Where/How can I download all proteins in the UniProt with signal peptide annotated?
ThreadText: # Where/How can I download all proteins in the UniProt with signal peptide annotated?
  
  (Asked by: username_0 on 2023-02-01)
  
  Where/How can I download all proteins in the UniProt with signal peptide annotated? I downloaded the uniref50.xml. However, the annotation information is not contained.
  
  In an XML record of a protein, the signal peptide information is contained in `<feature type="signal peptide" evidence="2"> </feature>`. The uniref.xml does not have this information. uniprot annotates this feature with signalp mainly.
  
  **Tags:** uniprot
  
  > **Comments:**
  > **username_1**: Please edit the question to limit it to a specific problem with enough detail to identify an adequate answer.  
  > **username_2**: Do you have a reason to expect that the signal peptide should be annotated there? Can you point us to more information about how uniprot annotates such features?  
  
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  ## 0 answers
  
  