Answers.Body: <p>In the end I manage to do 2 cohorts
  1: Long Covid Patients (1300N)
  2: NON Long Covid Patients that had Covid (1300).</p>
  <p>It was the most rational thing to do, and professor liked it. So that's how I manage in th end.</p>
  
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2021-10-19T15:31:27.360Z
Answers.LastActivityDate: 2021-10-19T15:31:27.360Z
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Body: <p>I am working on a project proposal for an exam, it involves a budget of 1M euros and I got to design a genomic study. I chose a GWAS to assess altered gene expression after covid19 that leads to long-COVID. I thought about 3 cohorts:</p>
  <p>Case cohort1: Long-Covid patients (N: 3,000)</p>
  <p>Case cohort2: Fully recovered patients (N: 3000)</p>
  <p>Control cohort: healthy patients. (N: 6000)</p>
  <p>Would it make sense to run two GWAS for the two case cohorts against the control cohort (cohort1/controls and cohort2/controls) then do a miami plot to see if there are some hits that differs from the two cohorts, and pick the ones only presented in the Long-covid for further assessment?</p>
  <p>The study will also be supported by a validation step for both gwas. What do you think about this idea? Would it make sense or the fully-recovered patients against control cohorts is totally useless? Thank you in advance</p>
  
Tags: <covid-19><gwas>
Title: Long-Covid (LC) GWAS project proposal: should I include a non-LC GWAS?
ThreadText: # Long-Covid (LC) GWAS project proposal: should I include a non-LC GWAS?
  
  (Asked by: username_0 on 2021-07-04)
  
  I am working on a project proposal for an exam, it involves a budget of 1M euros and I got to design a genomic study. I chose a GWAS to assess altered gene expression after covid19 that leads to long-COVID. I thought about 3 cohorts:
  
  Case cohort1: Long-Covid patients (N: 3,000)
  
  Case cohort2: Fully recovered patients (N: 3000)
  
  Control cohort: healthy patients. (N: 6000)
  
  Would it make sense to run two GWAS for the two case cohorts against the control cohort (cohort1/controls and cohort2/controls) then do a miami plot to see if there are some hits that differs from the two cohorts, and pick the ones only presented in the Long-covid for further assessment?
  
  The study will also be supported by a validation step for both gwas. What do you think about this idea? Would it make sense or the fully-recovered patients against control cohorts is totally useless? Thank you in advance
  
  **Tags:** covid-19, gwas
  
  
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  ## 1 answers
  
  ### Answer by username_0 on 2021-10-19. Score: 2 | Accepted answer
  
  In the end I manage to do 2 cohorts
  1: Long Covid Patients (1300N)
  2: NON Long Covid Patients that had Covid (1300).
  
  It was the most rational thing to do, and professor liked it. So that's how I manage in th end.
  
  
  ---
  
  