Answers.Body: <p>It might be used differently in different contexts, but generally speaking, in my world - allelic imbalance is when there's a difference in the level of gene expression from different alleles, usually through genetic (e.g. a variant in a promoter) or epigenetic mechanisms (e.g. one copy silenced, as in imprinted regions).</p>
  
  <p>There are a <a href="http://nathansheffield.com/wordpress/what-is-allelic-imbalance/" rel="nofollow noreferrer">few</a> <a href="https://www.rna-seqblog.com/direct-testing-for-allele-specific-expression-differences-between-conditions/" rel="nofollow noreferrer">blog</a> posts here with some more information, and plenty of papers (google "Allelic imbalance") if you want to dig deeper.</p>
  
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2018-11-29T13:13:59.283Z
Answers.LastActivityDate: 2018-12-03T16:50:20.507Z
Answers.LastEditDate: 2018-12-03T16:50:20.507Z
Answers.UserDisplayName: JenG
Body: <p>Can anyone help me explain what allelic imbalance is, hopefully shortly? 
  Surprisingly, we cannot find any introduction online. </p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2018-11-29T11:49:39.433Z
Comments.Text: Some more context would help. Where did you see the term? Is it with respect to a phenotype? A gene? A population? An individual?
Comments.UserDisplayName: terdon
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2018-11-29T14:31:41.180Z
Comments.Text: You may also consider looking into allele-specific expression. That may turn up more information on allelic imbalance.
Comments.UserDisplayName: LucasBoatwright
Tags: <phylogenetics>
Title: What is Allelic Imbalance
ThreadText: # What is Allelic Imbalance
  
  (Asked by: username_0 on 2018-11-29)
  
  Can anyone help me explain what allelic imbalance is, hopefully shortly?
  Surprisingly, we cannot find any introduction online.
  
  **Tags:** phylogenetics
  
  > **Comments:**
  > **username_1**: Some more context would help. Where did you see the term? Is it with respect to a phenotype? A gene? A population? An individual?  
  > **username_2**: You may also consider looking into allele-specific expression. That may turn up more information on allelic imbalance.  
  
  ---
  
  ## 1 answers
  
  ### Answer by username_3 on 2018-11-29. Score: 5 | Accepted answer
  
  It might be used differently in different contexts, but generally speaking, in my world - allelic imbalance is when there's a difference in the level of gene expression from different alleles, usually through genetic (e.g. a variant in a promoter) or epigenetic mechanisms (e.g. one copy silenced, as in imprinted regions).
  
  There are a [few](http://nathansheffield.com/wordpress/what-is-allelic-imbalance/) [blog](https://www.rna-seqblog.com/direct-testing-for-allele-specific-expression-differences-between-conditions/) posts here with some more information, and plenty of papers (google "Allelic imbalance") if you want to dig deeper.
  
  
  ---
  
  