Answers.Body: <p>The enzyme EC:1.6.1.2 is an NAD(P) transhydrogenase and consists of two subunits. The two subunits are encoded by two different genes <a href="http://www.genome.jp/dbget-bin/www_bget?sco+SCO7623" rel="nofollow noreferrer">pntA</a> and <a href="http://www.genome.jp/dbget-bin/www_bget?sco:SCO7622" rel="nofollow noreferrer">pntB</a>.</p>
  
  <p>So in terms of computer logic I would say AND, both subunits are necessary for a functional NAD(P) transhydrogenase enzyme (EC:1.6.1.2).</p>
  
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Answers.CreationDate: 2017-12-12T15:13:26.117Z
Answers.Text: This was only an example, is there a way of knowing in general?
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Answers.Text: With enzymes from KEGG there is not, I am afraid. In your example it becomes clear that we see 2 subunits, and hence form the same protein. However, if you look for example at human isocitrate dehydrogenase (IDH) [EC 1.1.1.42](http://www.genome.jp/dbget-bin/www_bget?ec:1.1.1.42), you will see that two different genes (IDH1 and IDH2) are listed. These 2 genes are not subunits of the same protein but are 2 different proteins (one in mitochondrium and the other in cytosol). With KEGG the interest in enzyme, not gene.
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Body: <p>How do I know if it is a AND or OR relationship between genes associated with the same enzyme in KEGG? E.g., for EC:1.6.1.2 (<a href="http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2" rel="nofollow noreferrer">http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2</a>) does the bacterium <em>Streptomyces coelicolor</em> (SCO) need SCO7622 AND SCO7623 or SCO7622 OR SCO7623? <a href="https://i.sstatic.net/zIaRw.png" rel="nofollow noreferrer"><img src="https://i.sstatic.net/zIaRw.png" alt="enter image description here"></a> </p>
  
Tags: <gene><kegg>
Title: AND or OR gene - protein logical relation in KEGG
ThreadText: # AND or OR gene - protein logical relation in KEGG
  
  (Asked by: username_0 on 2017-12-11)
  
  How do I know if it is a AND or OR relationship between genes associated with the same enzyme in KEGG? E.g., for EC:1.6.1.2 (<http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2>) does the bacterium *Streptomyces coelicolor* (SCO) need SCO7622 AND SCO7623 or SCO7622 OR SCO7623? [![enter image description here](https://i.sstatic.net/zIaRw.png)](https://i.sstatic.net/zIaRw.png)
  
  **Tags:** gene, kegg
  
  
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  ## 1 answers
  
  ### Answer by username_1 on 2017-12-11. Score: 1
  
  The enzyme EC:1.6.1.2 is an NAD(P) transhydrogenase and consists of two subunits. The two subunits are encoded by two different genes [pntA](http://www.genome.jp/dbget-bin/www_bget?sco+SCO7623) and [pntB](http://www.genome.jp/dbget-bin/www_bget?sco:SCO7622).
  
  So in terms of computer logic I would say AND, both subunits are necessary for a functional NAD(P) transhydrogenase enzyme (EC:1.6.1.2).
  
  > **Comments:**
  > **username_0**: This was only an example, is there a way of knowing in general?  
  > **username_1**: With enzymes from KEGG there is not, I am afraid. In your example it becomes clear that we see 2 subunits, and hence form the same protein. However, if you look for example at human isocitrate dehydrogenase (IDH) [EC 1.1.1.42](http://www.genome.jp/dbget-bin/www_bget?ec:1.1.1.42), you will see that two different genes (IDH1 and IDH2) are listed. These 2 genes are not subunits of the same protein but are 2 different proteins (one in mitochondrium and the other in cytosol). With KEGG the interest in enzyme, not gene.  
  
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