Body: <p>My group is interested in genetically engineering mice with label for the Slc45a2 gene, since &quot;the protein is expressed in a high percentage of melanoma cell lines&quot;. (from Refseq)
  How can I choose with high confidence the best isoform to use, i.e., the one that is most upregulated in melanoma cell lines?</p>
  <p>Is there a curated database/ web-source of any kind that I can look it up?</p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2022-11-16T15:11:50.487Z
Comments.Text: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.
Comments.UserDisplayName: Community
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2022-11-16T16:18:41.710Z
Comments.Text: MelGene database, https://pubmed.ncbi.nlm.nih.gov/25407435/
  and then more recent studies, e.g.
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927184/ . Just to note cancer isn't my thing, I just did a pubmed search.
Comments.UserDisplayName: M__
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2022-11-17T09:32:40.287Z
Comments.Text: Many Thanks. turns out this MelGene database no longer exists. at least I couldn't find any trace of it =\
Comments.UserDisplayName: Tom Gome
Tags: <isoform>
Title: Good source for specific Isoforms overexpression in tumor cells (specifically, melanoma)
ThreadText: # Good source for specific Isoforms overexpression in tumor cells (specifically, melanoma)
  
  (Asked by: username_0 on 2022-11-16)
  
  My group is interested in genetically engineering mice with label for the Slc45a2 gene, since "the protein is expressed in a high percentage of melanoma cell lines". (from Refseq)
  How can I choose with high confidence the best isoform to use, i.e., the one that is most upregulated in melanoma cell lines?
  
  Is there a curated database/ web-source of any kind that I can look it up?
  
  **Tags:** isoform
  
  > **Comments:**
  > **username_1**: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.  
  > **username_2**: MelGene database, https://pubmed.ncbi.nlm.nih.gov/25407435/ and then more recent studies, e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927184/ . Just to note cancer isn't my thing, I just did a pubmed search.  
  > **username_0**: Many Thanks. turns out this MelGene database no longer exists. at least I couldn't find any trace of it =\  
  
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  ## 0 answers
  
  