Answers.Body: <p>Did you try:</p>
  <pre><code>pip install scvi-tools
  </code></pre>
  <p>?</p>
  
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2022-11-30T22:33:39.417Z
Answers.Text: Would need venv (virtual env) with pip, but I agree I think this is the best approach in this particular scenario
Answers.UserDisplayName: M__
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2022-12-01T10:51:21.523Z
Answers.Text: https://scvi-tools.org/
Answers.UserDisplayName: envs_h_gang_5
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2022-11-30T21:55:59.440Z
Answers.LastActivityDate: 2022-11-30T21:55:59.440Z
Answers.UserDisplayName: Soerendip
Body: <p>I was wondering if somebody here has experience with installing scvi-tools on a Mac with M1 chip. I tried the following command:</p>
  <pre><code>conda install scvi-tools -c conda-forge
  </code></pre>
  <p>But got the following error:</p>
  <pre><code>Collecting package metadata (current_repodata.json): failed
  CondaSSLError: OpenSSL appears to be unavailable on this machine. OpenSSL is required to
  download and install packages.
  Exception: HTTPSConnectionPool(host='conda.anaconda.org', port=443): Max retries exceeded with url: /conda-forge/osx-64/current_repodata.json (Caused by SSLError(&quot;Can't connect to HTTPS URL because the SSL module is not available.&quot;))
  </code></pre>
  <p>Then I tried to install OpenSSL with following command:</p>
  <pre><code>conda install -c anaconda openssl 
  </code></pre>
  <p>and I got the exact same error as the conda install scvi-tools -c conda-forge command.</p>
  <p>I do not understand why collection of metadata is failing for openssl. Any inputs would be highly helpful.
  Thanks!</p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2022-11-30T22:10:08.897Z
Comments.Text: There might be system incompatibilities, thats what my error log suggests. Thus I was unable to easily install as well. However this might be a Python version  issue (could be Python 3.6, I used 3.11 [not the best idea]). However the error log should have flagged that. `scvi-tools` is a bioinformatics tool, but please try and edit the question with the biological problem. I'd guess this is RNA-seq PCA type analysis
Comments.UserDisplayName: M__
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2022-12-01T22:44:18.950Z
Comments.Text: Wait, how did you end up with a non-working conda install on that M1 mac in the first place?  Looks like it's not complaining about a missing package dependency; it's complaining about not having openssl to do HTTPS downloads within conda.
Comments.UserDisplayName: Jesse
Tags: <software-installation>
Title: Struggling to install scvi-tools on Mac M1
ThreadText: # Struggling to install scvi-tools on Mac M1
  
  (Asked by: username_0 on 2022-11-30)
  
  I was wondering if somebody here has experience with installing scvi-tools on a Mac with M1 chip. I tried the following command:
  
  ```
  conda install scvi-tools -c conda-forge
  
  ```
  
  But got the following error:
  
  ```
  Collecting package metadata (current_repodata.json): failed
  CondaSSLError: OpenSSL appears to be unavailable on this machine. OpenSSL is required to
  download and install packages.
  Exception: HTTPSConnectionPool(host='conda.anaconda.org', port=443): Max retries exceeded with url: /conda-forge/osx-64/current_repodata.json (Caused by SSLError("Can't connect to HTTPS URL because the SSL module is not available."))
  
  ```
  
  Then I tried to install OpenSSL with following command:
  
  ```
  conda install -c anaconda openssl 
  
  ```
  
  and I got the exact same error as the conda install scvi-tools -c conda-forge command.
  
  I do not understand why collection of metadata is failing for openssl. Any inputs would be highly helpful.
  Thanks!
  
  **Tags:** software-installation
  
  > **Comments:**
  > **username_1**: There might be system incompatibilities, thats what my error log suggests. Thus I was unable to easily install as well. However this might be a Python version  issue (could be Python 3.6, I used 3.11 [not the best idea]). However the error log should have flagged that. `scvi-tools` is a bioinformatics tool, but please try and edit the question with the biological problem. I'd guess this is RNA-seq PCA type analysis  
  > **username_2**: Wait, how did you end up with a non-working conda install on that M1 mac in the first place?  Looks like it's not complaining about a missing package dependency; it's complaining about not having openssl to do HTTPS downloads within conda.  
  
  ---
  
  ## 1 answers
  
  ### Answer by username_3 on 2022-11-30. Score: 2
  
  Did you try:
  
  ```
  pip install scvi-tools
  
  ```
  
  ?
  
  > **Comments:**
  > **username_1**: Would need venv (virtual env) with pip, but I agree I think this is the best approach in this particular scenario  
  > **username_4**: https://scvi-tools.org/  
  
  ---
  
  