Answers.Body: <p><em>Answer from @devon-ryan, converted from comments:</em></p>
  <p>The common presumption in such cases is that there's a feedback loop on most genes to control their expression level. It doesn't have to be specific to arm-level expression.</p>
  
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Answers.CreationDate: 2021-07-14T11:56:24.953Z
Answers.LastActivityDate: 2021-07-14T11:56:24.953Z
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Body: <p>It is almost common sense that local amplification of gene increase the its mRNA expression . I recently heard that large scale SCNA (such as arm-level amplification) does not increase the mRNA expression level of gene within the region. I did some analysis (SCNA is determined by SNP array and NGS, mRNA expression is measured by RNA-Seq) and found that this is indeed the case. I further did some research and did not found any explanations. it seems like a common acknowledgement. Is there any technical bias or biological explanation that I am missing here? Or is it something that has not have a answer yet?</p>
  <p>I have no clue about this at all. Can you recommend this papers on this?</p>
  
Tags: <rna><cnv>
Title: Arm-level SCNA does not change mRNA expression level?
ThreadText: # Arm-level SCNA does not change mRNA expression level?
  
  (Asked by: username_0 on 2019-11-24)
  
  It is almost common sense that local amplification of gene increase the its mRNA expression . I recently heard that large scale SCNA (such as arm-level amplification) does not increase the mRNA expression level of gene within the region. I did some analysis (SCNA is determined by SNP array and NGS, mRNA expression is measured by RNA-Seq) and found that this is indeed the case. I further did some research and did not found any explanations. it seems like a common acknowledgement. Is there any technical bias or biological explanation that I am missing here? Or is it something that has not have a answer yet?
  
  I have no clue about this at all. Can you recommend this papers on this?
  
  **Tags:** rna, cnv
  
  
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  ## 1 answers
  
  ### Answer by username_1 on 2021-07-14. Score: 1
  
  *Answer from @devon-ryan, converted from comments:*
  
  The common presumption in such cases is that there's a feedback loop on most genes to control their expression level. It doesn't have to be specific to arm-level expression.
  
  
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