Answers.Body: <p>I think these definitions still have a degree of subjectivity and I don't think they are mutually exclusive.</p>
  
  <p>Convergent amplification basically means that "similar" cancers/neoplasms have "similar" amplification patterns, i.e. at around the same loci (see <a href="https://www.ncbi.nlm.nih.gov/pubmed/16751803" rel="nofollow noreferrer">Myllykangas S et al.,2006</a> for an example).</p>
  
  <p>Focal genome amplification is defined as "CNA [copy number alteration] of limited size, frequently enriched for cancer driver genes" (<a href="https://www.sciencedirect.com/science/article/pii/S0167488914003000?via%3Dihub" rel="nofollow noreferrer">Krijgsmanthis et al., 2014</a>).</p>
  
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Body: <p>I am working on cancer genomics failed to follow some terms even by googling </p>
  
  <p>What is the difference of <strong><em>focal genome amplifications</em></strong> versus <strong><em>convergent amplification</em></strong> of given region of genome for instance fibroblast growth factors region?</p>
  
  <p>Thank you for any clarification </p>
  
Tags: <genomics><wgs><copy-number>
Title: What does these terms mean?
ThreadText: # What does these terms mean?
  
  (Asked by: username_0 on 2019-12-30)
  
  I am working on cancer genomics failed to follow some terms even by googling
  
  What is the difference of ***focal genome amplifications*** versus ***convergent amplification*** of given region of genome for instance fibroblast growth factors region?
  
  Thank you for any clarification
  
  **Tags:** genomics, wgs, copy-number
  
  
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  ## 1 answers
  
  ### Answer by username_1 on 2019-12-30. Score: 1 | Accepted answer
  
  I think these definitions still have a degree of subjectivity and I don't think they are mutually exclusive.
  
  Convergent amplification basically means that "similar" cancers/neoplasms have "similar" amplification patterns, i.e. at around the same loci (see [Myllykangas S et al.,2006](https://www.ncbi.nlm.nih.gov/pubmed/16751803) for an example).
  
  Focal genome amplification is defined as "CNA [copy number alteration] of limited size, frequently enriched for cancer driver genes" ([Krijgsmanthis et al., 2014](https://www.sciencedirect.com/science/article/pii/S0167488914003000?via%3Dihub)).
  
  
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