Answers.Body: <p>try somalier: <a href="https://github.com/brentp/somalier" rel="nofollow noreferrer">https://github.com/brentp/somalier</a></p>
  <p><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2" rel="nofollow noreferrer">https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2</a> :</p>
  <blockquote>
  <p>The sites files include informative variants on the X and Y chromosomes so that Somalier can also estimate a sample’s sex from the genotypes.</p>
  </blockquote>
  
Answers.ContentLicense: CC BY-SA 4.0
Answers.CreationDate: 2024-08-08T08:47:47.083Z
Answers.LastActivityDate: 2024-08-08T08:47:47.083Z
Answers.UserDisplayName: Pierre
Body: <p>I have human samples VCF files that I want to infer the sex of. I do not have sequencing information or information about coverage. What's the best way to go about this? I'm looking for a robust and reliable method. Tools are okay, and conceptual or algorithmic ideas about what to do are also okay.</p>
  
Tags: <vcf><snp><plink><algorithms><human-genome>
Title: How do I infer sex from a VCF file?
ThreadText: # How do I infer sex from a VCF file?
  
  (Asked by: username_0 on 2024-08-06)
  
  I have human samples VCF files that I want to infer the sex of. I do not have sequencing information or information about coverage. What's the best way to go about this? I'm looking for a robust and reliable method. Tools are okay, and conceptual or algorithmic ideas about what to do are also okay.
  
  **Tags:** vcf, snp, plink, algorithms, human-genome
  
  
  ---
  
  ## 1 answers
  
  ### Answer by username_1 on 2024-08-08. Score: 1
  
  try somalier: <https://github.com/brentp/somalier>
  
  <https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2> :
  
  > The sites files include informative variants on the X and Y chromosomes so that Somalier can also estimate a sample’s sex from the genotypes.
  
  
  ---
  
  