Body: <p>I’m trying to understand how bioinformatics tools import BS files, especially in terms of merging methylation data from the forward and reverse strands. How is this information represented in the final output? For instance, what happens when the CpG sites are symmetric, when data is available from only one strand, or when the two strands have differing methylation statuses? Thank you:).
  <a href="https://i.sstatic.net/zOnrzkm5.png" rel="nofollow noreferrer"><img src="https://i.sstatic.net/zOnrzkm5.png" alt="enter image description here" /></a></p>
  
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2024-12-07T00:56:32.880Z
Comments.Text: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.
Comments.UserDisplayName: Community
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2024-12-07T06:17:30.740Z
Comments.Text: What are BS files? Do you have any example files (e.g. the first few lines of a file)?
Comments.UserDisplayName: gringer
Comments.ContentLicense: CC BY-SA 4.0
Comments.CreationDate: 2024-12-07T10:02:29.987Z
Comments.Text: Hi, i have added an example pic :).
Comments.UserDisplayName: Jessica
Tags: <methylation><differential-methylation>
Title: how to combine cpg information on both strands in analysis?
ThreadText: # how to combine cpg information on both strands in analysis?
  
  (Asked by: username_0 on 2024-12-07)
  
  I’m trying to understand how bioinformatics tools import BS files, especially in terms of merging methylation data from the forward and reverse strands. How is this information represented in the final output? For instance, what happens when the CpG sites are symmetric, when data is available from only one strand, or when the two strands have differing methylation statuses? Thank you:).
  [![enter image description here](https://i.sstatic.net/zOnrzkm5.png)](https://i.sstatic.net/zOnrzkm5.png)
  
  **Tags:** methylation, differential-methylation
  
  > **Comments:**
  > **username_1**: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.  
  > **username_2**: What are BS files? Do you have any example files (e.g. the first few lines of a file)?  
  > **username_0**: Hi, i have added an example pic :).  
  
  ---
  
  ## 0 answers
  
  