Protein-coding gene in the species Homo sapiens
Ubiquilin-1 is a protein that in humans is encoded by the "UBQLN1" gene.
Ubiquilins contain two domains, an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect "in vivo" protein degradation.
Functions.
Ubiquilin-1 is associated with protein degradation and aggregation of misfolded proteins, and may be involved in neurodegenerative diseases. Ubiquilin-1 has been reported to act as a molecular chaperone for amyloid precursor protein (APP), a protein associated with Alzheimer's disease. 
Ubiquilin-1 was first identified through its interactions with presenilins. Two transcript variants encoding different isoforms have been found for this gene.
Related proteins.
Human UBQLN1 shares a high degree of similarity with related ubiquilins including UBQLN2 and UBQLN4.
Interactions.
UBQLN1 has been shown to interact with
References.
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Further reading.
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