Chemical compound
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Quisinostat (USAN; development code JNJ-26481585) is an experimental drug candidate for the treatment of cancer. It is a "second generation" histone deacetylase inhibitor with antineoplastic activity. It is highly potent against class I and II HDACs.
History.
It was developed by Janssen Pharmaceuticals and licensed to NewVac LLC.
Preclinical studies show that quisinostat amplifies HDAC-repressed expression of E-cadherin, leading to a reversal of epithelial to mesenchymal transition in tumor cells.
Clinical trials.
Results of a phase I trials in patients with multiple myeloma in combination with bortezomib and dexamethasone were published in 2016.
References.
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