Protein-coding gene in the species Homo sapiens
HLA class II histocompatibility antigen, DQ(6) alpha chain is a protein that in humans is encoded by the "HLA-DQA2" gene. Also known as "HLA-DXA" or "DAAP-381D23.2", it is part of the human leukocyte antigen system.
The protein encoded by this gene is expressed, but unlike HLA-DQA1, it is apparently unable to heterodimerize with HLA class II beta chain paralogues. The low level of HLA-DQA2 expression is apparently due to impaired transcription factor binding to the HLA-DQA2 gene promoter.
COVID-19.
Transcriptome analysis of blood immune cells and nasopharyngeal cells before elaborate infection of study participants revealed that heightened expression of HLA-DQA2 correlates to a significantly lower chance of COVID-19 successfully infecting the individual.
References.
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Further reading.
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