Class of enzymes
In enzymology, an UDP-glucose—hexose-1-phosphate uridylyltransferase (EC 2.7.7.12) is an enzyme that catalyzes the chemical reaction
UDP-glucose + alpha-D-galactose 1-phosphate formula_1 alpha-D-glucose 1-phosphate + UDP-galactose
Thus, the two substrates of this enzyme are UDP-glucose and alpha-D-galactose 1-phosphate, whereas its two products are alpha-D-glucose 1-phosphate and UDP-galactose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase. Other names in common use include uridyl transferase, hexose-1-phosphate uridylyltransferase, uridyltransferase, and hexose 1-phosphate uridyltransferase. This enzyme participates in galactose metabolism and nucleotide sugars metabolism.
Structural studies.
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1HXQ, 2H39, 2Q4H, and 2Q4L.
References.
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