Protein-coding gene in the species Homo sapiens
Solute carrier family 26 member 6 is a protein that in humans is encoded by the "SLC26A6" gene. It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.
Associated diseases.
Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."