Protein-coding gene in the species Homo sapiens
Interferon-induced protein with tetratricopeptide repeats 2 (commonly termed IFIT2) is a protein that in humans is directed to be produced by the "IFIT2" gene. Previously, this gene was termed the "G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54," or "P54" gene and the protein that it directs to be produced was termed the G10P2, GARG-39, IFI-54, IFI-54K, IFI54, IFIT-2, ISG-54 K, ISG-54K, ISG54, or P54 protein. The "IFIT2" gene is one of the many genes that are stimulated by type 1 interferons to form their messenger RNAs and thereby their product proteins. Consequently, the IFIT2 gene is classified as one the many type 1 interferon-stimulated genes.
Clinical significance.
IFIT2 may play a role in preventing tumor progression. Indeed, IFIT2 gene has been detected progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.
References.
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Further reading.
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