Protein-coding gene in the species Homo sapiens
Prolyl 4-hydroxylase, transmembrane is a protein that in humans is encoded by the P4HTM gene.
Function.
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified.
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."