Protein-coding gene in the species Homo sapiens
DNA-binding protein inhibitor ID-3 is a protein that in humans is encoded by the "ID3" gene.
Function.
Members of the ID family of helix-loop-helix (HLH) proteins lack a basic DNA-binding domain and inhibit transcription through formation of nonfunctional dimers that are incapable of binding to DNA.[supplied by OMIM]
Interactions.
ID3 (gene) has been shown to interact with TCF3.
Repressors of ID3.
BTG2 binds to the promoter of Id3 and represses its activity. By this mechanism, the upregulation of Id3 in the hippocampus caused by BTG2 ablation prevents terminal differentiation of hippocampal neurons.
References.
 ;templatestyles src="Reflist/styles.css" / ;
Further reading.
 ;templatestyles src="Refbegin/styles.css" / ;
External links.
"This article incorporates text from the United States National Library of Medicine, which is in the public domain."