Species of oncocytic human adenovirus
Enadenotucirev is an investigational oncolytic virus that is in clinical trials for various cancers.
It is an oncolytic A11/Ad3 Chimeric Group B Adenovirus, previously described as ColoAd1.
Enadenotucirev has also been modified with additional genes using the tumor-specific immuno-gene therapy (T-SIGn) platform to develop novel cancer gene therapy agents.
The T-SIGn vectors at clinical study stage are:
In Jan 2015 the European Medicines Agency's (EMA) Committee for Orphan Medical Products (COMP) designated enadenotucirev as an orphan medicinal product for the treatment of ovarian cancer.
Clinical trials.
Two clinical trials have been completed with enadenotucirev. The EVOLVE study and the MOA study.
As of  2019[ [update]], there are two active phase 1 trials: OCTAVE (in ovarian cancer) and SPICE (in multiple solid tumor indications) 
Of the T-SIGn viruses, NG-350A has an ongoing clinical study.
References.
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