The Multiple Sclerosis Functional Composite (MSFC) is a clinical trial outcome measure of assessing the severity of multiple sclerosis primarily used in research. The score is based on a combination of timed tests of walking, arm function, and cognitive ability. It was developed over two years from 1994 to 1996 by the National Multiple Sclerosis Society.
MSFC was developed to improve the standard measure of MS disability for clinical trials and to create a multidimensional metric of overall MS clinical status. The evaluation includes a three-part performance scale:
An integrated MSFC score is calculated using z-scores.
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