OrthoFinder is a command-line software tool for comparative genomics. OrthoFinder determines the correspondence between genes in different organisms (also known as orthology analysis). This correspondence provides a framework for understanding the evolution of life on Earth, and enables the extrapolation and transfer of biological knowledge between organisms. 
OrthoFinder takes FASTA files of protein sequences as input (one per species) and as output provides:
As of August 2021, the tool has been referenced by more than 1500 published studies.