Mammalian protein found in Homo sapiens
Folylpolyglutamate synthase, mitochondrial is an enzyme that in humans is encoded by the "FPGS" gene.
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. While several transcript variants may exist for this gene, the full-length natures of only two have been biologically validated to date. These two variants encode distinct isoforms.
Interactive pathway map.
"Click on genes, proteins and metabolites below to link to respective articles." 
Fluorouracil (5-FU) Activity edit
 ;templatestyles src="Reflist/styles.css" / ;
References.
 ;templatestyles src="Reflist/styles.css" / ;
Further reading.
 ;templatestyles src="Refbegin/styles.css" / ;