SAM-VI is a member of the riboswitch family. It is predominantly found in "Bifidobacterium" and exhibits some similarities to the SAM-III (Smk box) riboswitch class, but lacks most of the highly conserved nucleotides of SAM-III class. SAM-VI aptamers bind the cofactor S-adenosylmethinine SAM (a key metabolite in sulphur metabolism) and discriminate strongly against S-adenosylhomocysteine SAH. The class was discovered by further analysis of Bifido-"meK" motif RNAs.
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