In enzymology, a glutamate—tRNA ligase (EC 6.1.1.17) is an enzyme that catalyzes the chemical reaction
ATP + L-glutamate + tRNAGlu formula_1 AMP + diphosphate + L-glutamyl-tRNAGlu
The 3 substrates of this enzyme are ATP, L-glutamate, and tRNA(Glu), whereas its 3 products are AMP, diphosphate, and L-glutamyl-tRNA(Glu).
This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-glutamate:tRNAGlu ligase (AMP-forming). Other names in common use include glutamyl-tRNA synthetase, glutamyl-transfer ribonucleate synthetase, glutamyl-transfer RNA synthetase, glutamyl-transfer ribonucleic acid synthetase, glutamate-tRNA synthetase, and glutamic acid translase. This enzyme participates in 3 metabolic pathways: glutamate metabolism, porphyrin and chlorophyll metabolism, and aminoacyl-trna biosynthesis.
Structural studies.
As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes 1FYJ, 1G59, 1J09, 1N75, 1N77, 1N78, 2CFO, 2CUZ, 2CV0, 2CV1, 2CV2, 2DXI, 2HRA, 2HRK, 2HSM, and 2O5R.
References.
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