Class of enzymes
The enzyme 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) catalyzes the reaction
1-alkyl-2-acetyl-"sn"-glycero-3-phosphocholine + H2O formula_1 1-alkyl-"sn"-glycero-3-phosphocholine + acetate
The former is also known as platelet-activating factor. There are multiple enzymes with this function:
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is 1-alkyl-2-acetyl-"sn"-glycero-3-phosphocholine acetohydrolase. Other names in common use include 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase, and alkylacetyl-GPC:acetylhydrolase. This enzyme participates in ether lipid metabolism.
Structural studies.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1BWP, 1BWQ, 1BWR, 1ES9, 1FXW, 1VYH, and 1WAB.
References.
 ;templatestyles src="Reflist/styles.css" / ;