In enzymology, a formimidoylglutamase (EC 3.5.3.8) is an enzyme that catalyzes the chemical reaction
N-formimidoyl-L-glutamate + H2O formula_1 L-glutamate + formamide
Thus, the two substrates of this enzyme are N-formimidoyl-L-glutamate and H2O, whereas its two products are L-glutamate and formamide.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is N-formimidoyl-L-glutamate formimidoylhydrolase. Other names in common use include formiminoglutamase, N-formiminoglutamate hydrolase, and N-formimino-L-glutamate formiminohydrolase. This enzyme participates in histidine metabolism.
Structural studies.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XFK and 2A0M.
References.
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