The "Caenorhabditis elegans" "sel-12" gene encodes a multi-pass transmembrane domain protein that is similar to human presenilin. "sel-12" positively regulates the "lin-12" and "glp-1" Notch signaling pathways during hermaphrodite gonadal, vulval, and germline development. "sel-12" also plays a role in thermotaxis (the nematode worm prefers a certain temperature and moves accordingly).
"C. elegans" gene abbreviations: "sel", Suppressor/Enhancer of "Lin-12"; "lin", cell LINeage defective; "glp", Germ Line Proliferation defective.
External links.
"sel-12" gene summary (WormBase) 
References.
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