Dutch mass spectrometry researcher
Ron M.A. Heeren (born 1965, Tilburg) is a Dutch scientist in mass spectrometry imaging. He is currently a distinguished professor at Maastricht University and the scientific director of the Multimodal Molecular Imaging Institute (M4I), where he heads the division of Imaging Mass Spectrometry.
Scientific career.
Heeren obtained a PhD degree in Technical Physics at the University of Amsterdam in 1992 under the supervision of Aart Kleyn.
He led a FOM-AMOLF research group on macromolecular ion physics and biomolecular imaging mass spectrometry (1995–2014). He was also professor at the chemistry faculty of Utrecht University in 2001–2019.
Between 1995 and 2015, he worked on new approaches towards high spatial resolution and high-throughput molecular imaging mass spectrometry using secondary ion mass spectrometry (SIMS) and matrix-assisted laser desorption and ionization (MALDI).
Heeren has coauthored over 300 peer-reviewed articles, which have been cited over 12,600 times (Google Scholar).
Research.
Heeren’s academic research interests are fundamental studies of the energetics of macromolecular systems, conformational studies of non-covalently bound protein complexes, translational imaging research, high-throughput bioinformatics, and the development and validation of new mass spectrometry–based proteomic imaging techniques for the life sciences.
During his postdoctoral fellowship, he worked on the development of innovative ion sources, vacuums systems, data acquisition systems and novel temperature-controlled ion cyclotron resonance cells. He used the FTICR-MS instrument for the study of collisional energy transfer and internal energy distributions. These methods were deployed to investigate their role in the determination of dissociation pathways of biomolecular systems.
As a project leader (1995–1997), Heeren led the application of high-resolution MS (FTICR-MS, FTIR imaging spectroscopy and SIMS) to the field of conservation science. He discovered and identified saponified pigment particulates in so-called protrusions in Rembrandt’s “The Anatomy Lesson of Dr. Nicolaes Tulp” in collaboration with the Mauritshuis museum in The Hague.
Heeren and his group have pioneered the development of active pixelated detectors for mass spectrometry imaging. One such detector, the Medipix detector has been adapted to enable microscope-mode imaging mass spectrometry for biomolecules to enable combined high-throughput and high-resolution molecular imaging using MALDI and SIMS.
Professional activities.
From 2008 to 2013, Heeren was the research director for emerging technologies at the Netherlands Proteomics Centre. In 2014, he was appointed to his current position as one of the scientific directors of M4I at Maastricht University. He was president of the Dutch Society of Mass Spectrometry between 2001–2005. He is one of the founding members of the Mass Spectrometry Imaging Society, and was elected its president in 2017.
Commercialization.
Heeren holds 7 patents and has established two spin-off companies, Omics2Image/ASI and the Dutch Screening Group. In 2019, he was awarded the NWO Valorisation Prize in Physics.
References.
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