The 2021–22 season was the seventh season in the existence of FC Nizhny Novgorod and the club's first season in the top flight of Russian football. In addition to the domestic league, FC Nizhny Novgorod participated in this season's editions of the Russian Cup, where they were eliminated in round of sixteen.
Season events.
On 16 March, Nizhny Novgorod suspended their contract with Lars Olden Larsen, and terminated their contract with Sylvester Igboun by mutual consent.
Players.
 ;templatestyles src="Template:Football squad player/styles.css" / ;
Contacts suspended.
 ;templatestyles src="Template:Football squad player/styles.css" / ;
Out on loan.
 ;templatestyles src="Template:Football squad player/styles.css" / ;
Friendlies.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Competitions.
Premier League.
Matches.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Russian Cup.
Group stage.
 ;onlyinclude ;
 ;/onlyinclude ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Knockout stage.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 "As of match played 21 May 2022"
Squad statistics.
Clean sheets.
Anisimov &amp; Sinitsyn both played in Nizhny Novgorod 1-0 victory over Dynamo Barnaul on 22 September 2021 ;br ;
References.
 ;templatestyles src="Reflist/styles.css" / ;