Painting by the Master Bertram
The Grabow Altarpiece (also known as the Petri Altar) was painted by Master Bertram around 1379–1383. Originally located in St. Petri church, it is now in the Hamburger Kunsthalle in Hamburg, Germany.
It includes the earliest known depiction of the Rest on the Flight into Egypt 
(lower row, last section on the right).
References.
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External links.
Hamburger Kunsthalle webpage showing the full altarpiece (main image, exterior description, interior description)