The Berkeley Piano Club was founded in 1893 by Berkeley women. In 1912 the club built a clubhouse designed by William L. Woollett with an internationally known performance space. It was designated by the city as a Berkeley Landmark in 2005. The designation also includes the house, final home of John Galen Howard (his wife was club president from 1911–1913), in an upstairs workshop of which a trigger was designed for the atomic bomb by a Manhattan Project scientist. The landmark designation made the property eligible for state funding and a restoration was also completed in 2005.
Nicolas Slonimsky lectured at the clubhouse in 1971.
The club published a history for its centennial, "The Berkeley Piano Club: One Hundred Years of Harmony" by Mary F. Commanday.
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