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Chemical compound
Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad ("Bombina bombina") by Vittorio Erspamer "et al." and named after its source. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop eating behaviour.
Bombesin is also a tumor marker for small cell carcinoma of lung, gastric cancer, pancreatic cancer, and neuroblastoma.
Receptors.
The anuran ;templatestyles src="Template:Visible anchor/styles.css" / ;BB4 receptor homologue is termed ;templatestyles src="Template:Visible anchor/styles.css" / ;frog BB4 ( ;templatestyles src="Template:Visible anchor/styles.css" / ;fBB4). Iwabuchi "et al." 2003 discovered a chicken ("Gallus domesticus") receptor which is homologous to both the ;templatestyles src="Template:Visible anchor/styles.css" / ;mammalian BB3 and fBB4 and so they named it ;templatestyles src="Template:Visible anchor/styles.css" / ;chBRS-3.5.
Effects.
Erspamer 1988 finds bombesin has a similar effect on the chicken to ranatensin, unreliably increasing or decreasing blood pressure.
References.
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