Protein-coding gene in the species Homo sapiens
Nuclear transcription factor Y subunit beta is a protein that in humans is encoded by the "NFYB" gene.
Function.
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.
Interactions.
NFYB has been shown to interact with:
References.
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Further reading.
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External links.
"This article incorporates text from the United States National Library of Medicine, which is in the public domain."