Anti-neurofascin demyelinating diseases (anti-NF diseases) refers to health conditions engendered by auto-antibodies against neurofascins, which can produce both central and peripheral demyelination. Some cases of combined central and peripheral demyelination (CCPD) could be produced by them.
Current status.
Whether ANFAs are part of a unique and emerging disease entity, disease modifiers, or inconsequential remains to be elucidated with time. Anti-neurofascin antibodies are found in multiple sclerosis, and chronic inflammatory demyelinating polyradiculoneuropathy.
History.
The first report about a subgroup of MS patients with anti-NF and contactin 2 auto-antibodies was published in 2011
References.
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