The Upytė is a river of Kėdainiai district municipality, Kaunas County, central Lithuania. It flows for and has a basin area of . It is a right tributary of the river Nevėžis.
It begins nearby Galulaukiai village. It flows mostly southwards and meets the Nevėžis between Karūnava and Vainikai villages. A little pond is dammed on the Upytė in Karūnava.
The name "Upytė" in Lithuanian means 'little river, rivulet'.
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