Protein-coding gene in the species Homo sapiens
Interleukin-10 receptor subunit alpha is a subunit for the interleukin-10 receptor. IL10RA is its human gene.
IL10RA has also been designated CDw210a (cluster of differentiation w210a).
Function.
The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of myeloid progenitor cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
Interactions.
Interleukin 10 receptor, alpha subunit has been shown to interact with:
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."