Protein-coding gene in the species Homo sapiens
WEE1 homolog ("S. pombe"), also known as WEE1, is a protein which in humans is encoded by the "WEE1" gene.
Function.
This gene encodes a nuclear protein, which is a tyrosine kinase belonging to the Ser/Thr family of protein kinases. This protein catalyzes the inhibitory tyrosine phosphorylation of CDC2/cyclin B kinase, and appears to coordinate the transition between DNA replication and mitosis by protecting the nucleus from cytoplasmically activated CDC2 kinase.
Interactions.
Wee1-like protein kinase has been shown to interact with YWHAB and PIN1.
References.
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Further reading.
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