Class of enzymes
In enzymology, a 2-dehydropantoate 2-reductase (EC 1.1.1.169) is an enzyme that catalyzes the chemical reaction
(R)-pantoate + NADP+ formula_1 2-dehydropantoate + NADPH + H+
Thus, the two substrates of this enzyme are (R)-pantoate and NADP+, whereas its 3 products are 2-dehydropantoate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-pantoate:NADP+ 2-oxidoreductase. Other names in common use include 2-oxopantoate reductase, 2-ketopantoate reductase, 2-ketopantoic acid reductase, ketopantoate reductase, and ketopantoic acid reductase. This enzyme participates in pantothenate and coa biosynthesis.
Structural studies.
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1KS9, 1YJQ, 1YON, 2EW2, and 2OFP.
References.
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