Class of enzymes
In enzymology, an UDP-sugar diphosphatase (EC 3.6.1.45) is an enzyme that catalyzes the chemical reaction
UDP-sugar + H2O formula_1 UMP + alpha-D-aldose 1-phosphate
Thus, the two substrates of this enzyme are UDP-sugar and H2O, whereas its two products are UMP and alpha-D-aldose 1-phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is UDP-sugar sugarphosphohydrolase. Other names in common use include nucleosidediphosphate-sugar pyrophosphatase, nucleosidediphosphate-sugar diphosphatase, UDP-sugar hydrolase, and UDP-sugar pyrophosphatase.
Structural studies.
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1HO5, 1HP1, 1HPU, 1OI8, 1OID, and 1OIE.
References.
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