APOPT (for Advanced Process OPTimizer) is a software package for solving large-scale optimization problems of any of these forms:
Applications of the APOPT include chemical reactors, 
friction stir welding, prevention of hydrate formation in deep-sea pipelines, computational biology, solid oxide fuel cells, and flight controls for Unmanned Aerial Vehicles (UAVs).
Benchmark Testing.
Standard benchmarks such as CUTEr and SBML curated models are used to test the performance of APOPT relative to solvers BPOPT, IPOPT, SNOPT, and MINOS. A combination of APOPT (Active Set SQP) and BPOPT (Interior Point Method) performed the best on 494 benchmark problems for solution speed and total fraction of problems solved.
References.
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