American physician
Jack Levin (born October 11, 1932) is an American physician-scientist and hematologist who, with Fred Bang, developed the Limulus amebocyte lysate (LAL) test for bacterial endotoxins.
Biography.
Jack Levin attended Yale School of Medicine (M.D.,1957). Levin joined the faculty of Johns Hopkins School of Medicine in 1965, transitioning to University of California School of Medicine in 1982.
His studies of blood coagulation in Limulus, the horseshoe crab, performed at the Marine Biological Laboratory (Woods Hole, MA), identified the key role of amebocytes, the only type of circulating blood cell in the horseshoe crab, in blood coagulation. His recognition of the sensitivity of amebocytes and subsequently of lysates prepared from washed amebocytes to bacterial endotoxins led to his original description of the Limulus amebocyte lysate (LAL) test for the detection of bacterial endotoxins in 1964. His studies of the biological effects of bacterial endotoxins and utilization of the Limulus Test for detection of endotoxin in the blood of patients with various clinical disorders led to his receiving the Bang Award for research in bacterial endotoxins and to election as an honorary life member of the International Endotoxin and Innate Immunity Society. In 2014, Dr. Levin received a special award from the Parenteral Drug Association in recognition of the 50th anniversary of his initial description of the Limulus Amebocyte Lysate (LAL) test. In 2019, he received a Golden Goose Award from the American Association for the Advancement of Science (AAAS), which recognizes researchers whose seemingly obscure, federally funded research has led to major breakthroughs in biomedical research, medical treatments, and computing and communications technologies.
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