Protein-coding gene in the species Homo sapiens
Alpha-1,3/1,6-mannosyltransferase ALG2 is an enzyme that is encoded by the "ALG2" gene. Mutations in the human gene are associated with congenital defects in glycosylation The protein encoded by the ALG2 gene belongs to two classes of enzymes: (EC 2.4.1.132) and (EC 2.4.1.257).
Function.
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).
Interactions.
ALG2 has been shown to interact with ANXA7 and ANXA11.
References.
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Further reading.
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