In enzymology, a glucose-1-phosphate thymidylyltransferase (EC 2.7.7.24) is an enzyme that catalyzes the chemical reaction
dTTP + alpha--glucose 1-phosphate formula_1 diphosphate + dTDP-glucose
Thus, the two substrates of this enzyme are dTTP and alpha--glucose 1-phosphate, whereas its two products are pyrophosphate and dTDP-glucose.
This enzyme belongs to the family of transferases, to be specific, those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). This enzyme participates in 3 metabolic pathways: nucleotide sugars metabolism, streptomycin biosynthesis, and polyketide sugar unit biosynthesis.
Nomenclature.
The systematic name of this enzyme class is dTTP:alpha--glucose-1-phosphate thymidylyltransferase. Other names in common use include:
Structural studies.
As of late 2007, 19 structures have been solved for this class of enzymes, with PDB accession codes 1FXO, 1FZW, 1G0R, 1G1L, 1G23, 1G2V, 1G3L, 1H5R, 1H5S, 1H5T, 1IIM, 1IIN, 1LVW, 1MC3, 1MP3, 1MP4, 1MP5, 2GGO, and 2GGQ.
References.
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