The 2020–21 Michigan Stars FC season was the club's second season playing in the third division National Independent Soccer Association and first full professional season.
Club.
Roster.
"As of April 19, 2021."
Friendlies.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Competitions.
NISA Fall season.
On June 4, NISA announced the initial details for the 2020 Fall Season with the member teams split into conferences, Eastern and Western.
Details for the Fall regular season were announced on July 31, 2020. The Stars will take part as a member of the Eastern Conference.
Matches.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Fall Playoffs.
All eight NISA teams qualified for the 2020 Fall tournament, which will be hosted at Keyworth Stadium in Detroit, Michigan, beginning on September 21 ending with the final on October 2.
Group stage.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
2021 Spring Season.
NISA Legends Cup.
NISA announced initial spring season plans in early February 2021, including starting the season with a tournament in Chattanooga, Tennessee with a standard regular season to follow. The tournament, now called the NISA Legends Cup, was officially announced on March 10 and is scheduled to run between April 13 and 25. All nine NISA members teams taking part in the Spring were divided into three team groups and played a round robin schedule. The highest placing group winner automatically qualified for the tournament final, while the second and third highest finishing teams overall played one-another in a semifinal to determine a second finalist.
The Stars were drawn into Group 1 alongside the debuting Maryland Bobcats FC and the returning San Diego 1904 FC.
Matches.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Regular season.
The Spring Season schedule was announced on March 18 with each association member playing eight games, four home and four away, in a single round-robin format.
Matches.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
U.S. Open Cup.
As a team playing in a recognized professional league, Michigan would normally be automatically qualified for the U.S. Open Cup. However, with the 2021 edition shorted due to the COVID-19 pandemic, NISA has only been allotted 1 to 2 teams spots. On March 29, U.S. Soccer announced 2020 Fall Champion Detroit City FC as NISA's representative in the tournament.
 "As of Match played June 25, 2021"
References.
 ;templatestyles src="Reflist/styles.css" / ;