 Boca de Cupé is a corregimiento in Pinogana District, Darién Province, Panama with a population of 1,167 as of 2010. Its population as of 1990 was 901; its population as of 2000 was 902.
The town is not served by any paved roads, with the Pan-American Highway to the north ending at Yaviza. It is reachable by boat up the Tuira River. Civilians are not permitted to travel farther east towards Colombia.
In the early 1900s, a single-gage railway ran to the town from the Cana gold mines. It ceased operating in 1911.
Villages within the corregimiento farther up the river include Sobiaquirú. 
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