The Žiedupė (or "Žiedupys") is a river of Kėdainiai district municipality, Kaunas County, central Lithuania. It flows for and has a basin area of . It is a left tributary of the river Šušvė.
It begins north to Josvainiai, nearby Šingaliai village. It flows mostly southwards and meets the Šušvė nearby Plaktiniai village. Josvainiai village, Pažiedupys and Plaktiniai are located on the banks of the Žiedupė.
The name "Žiedupė" is a compound noun and derives from the Lithuanian words "žiedas" ('flower, blosom' or 'ring') and "upė" ('river').
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