Chemical compound
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RU-24,969 is a serotonergic drug used in scientific research. It is a selective agonist of the serotonin 5-HT1A and 5-HT1B receptors, with 5-fold preference for the latter receptor over the former. It also has affinity for the serotonin 5-HT5A, 5-HT5B, and 5-HT7 receptors.
The drug produces MDMA-like locomotor hyperactivity in animals and this is thought to be mediated by activation of both serotonin 5-HT1A and 5-HT1B receptors. As with other serotonin 5-HT1B receptor agonists such as CP-94,253, RU-24,969 has also been found to increase the reinforcing properties of cocaine in animals, suggesting a role for serotonin 5-HT1B receptors in cocaine addiction as well.
RU-24,969 was first described in the scientific literature by 1980.
References.
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