Protein-coding gene in the species Homo sapiens
Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the "SULF2" gene.
Function.
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM]
References.
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Further reading.
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