The history of Syria covers events which occurred on the territory of the Syrian Arab Republic and events which occurred in the region of Syria. Throughout ancient times the territory of the Syrian Arab Republic was occupied and ruled by several empires, including the Sumerians, Mitanni, Assyrians, Babylonians, Egyptians, Hittites, Canaanites, Phoenicians, Arameans, Amorites, Persians, Greeks and Romans. Syria is considered to have emerged as an independent country for the first time on 24 October 1945, upon the signing of the United Nations Charter by the Syrian government, effectively ending France's mandate by the League of Nations to "render administrative advice and assistance to the population" of Syria, which came in effect in April 1946. 
On 21 February 1958, however, Syria merged with Egypt to create the United Arab Republic after plebiscitary ratification of the merger by voters in both countries, but seceded from it in 1961, thereby recovering its full independence. From 1963 until 2024, the Syrian Arab Republic had been ruled by the Ba’ath Party, run by the Assad family exclusively starting in 1970. At present, Syria has been fractured between rival forces due to the Syrian Civil War.
Prehistory.
The oldest remains found in Syria date from the Palaeolithic era (c.800,000 BCE). On 23 August 1993, a joint Japan-Syria excavation team discovered fossilized Paleolithic human remains at the Dederiyeh Cave some 400 km north of Damascus. The bones found in this massive cave were those of a Neanderthal child, estimated to have been about two years old, who lived in the Middle Palaeolithic era (ca. 200,000 to 40,000 years ago). Although many Neanderthal bones had been discovered already, this was practically the first time that an almost complete child's skeleton had been found in its original burial state.
Archaeologists have demonstrated that civilization in Syria was one of the most ancient on earth. Syria is part of the Fertile Crescent, and since approximately 10,000 BCE it was one of the centers of Neolithic culture (PPNA) where agriculture and cattle breeding appeared for the first time in the world. The Neolithic period (PPNB) is represented by rectangular houses of the Mureybet culture. In the early Neolithic period, people used vessels made of stone, gyps and burnt lime. Finds of obsidian tools from Anatolia are evidence of early trade relations. The cities of Hamoukar and Emar flourished during the late Neolithic and Bronze Age.
Ancient Near East.
The ruins of Ebla, near Idlib in northern Syria, were discovered and excavated in 1975. Ebla appears to have been an East Semitic speaking city-state founded around 3000 BCE. At its zenith, from about 2500 to 2400 BCE, it may have controlled an empire reaching north to Anatolia, east to Mesopotamia and south to Damascus. Ebla traded with the Mesopotamian states of Sumer, Akkad and Assyria, as well as with peoples to the northwest. Gifts from Pharaohs, found during excavations, confirm Ebla's contact with Egypt. Scholars believe the language of Ebla was closely related to the fellow East Semitic Akkadian language of Mesopotamia and to be among the oldest known written languages.
From the third millennium BCE, Syria was occupied and fought over successively by Sumerians, Eblaites, Akkadians, Assyrians, Egyptians, Hittites, Hurrians, Mitanni, Amorites and Babylonians.
Ebla was probably conquered into the Mesopotamian Akkadian Empire (2335–2154 BCE) by Sargon of Akkad around 2330 BCE. The city re-emerged, as the part of the nation of the Northwest Semitic speaking Amorites, a few centuries later, and flourished through the early second millennium BCE until conquered by the Indo-European Hittites. The Sumerians, Akkadians and Assyrians of Mesopotamia referred to the region as Mar.Tu or "The land of the Amurru" (Amorites) from as early as the 24th century BCE.
Parts of Syria were controlled by the Neo-Sumerian Empire, Old Assyrian Empire and Babylonian Empire between the 22nd and 18th centuries BCE.
The region was fought over by the rival empires of the Hittites, Egyptians, Assyrians and Mitanni between the 15th and 13th centuries BCE, with the Middle Assyrian Empire (1365–1050 BCE) eventually left controlling Syria.
When the Middle Assyrian Empire began to deteriorate in the late 11th century BCE, Canaanites and Phoenicians came to the fore and occupied the coast, and Arameans and Suteans supplanted the Amorites in the interior, as part of the general disruptions and exchanges associated with the Bronze Age Collapse and the Sea Peoples. During this period the bulk of Syria became known as Eber Nari and Aramea.
From the 10th century BCE the Neo-Assyrian Empire (935–605 BCE) arose, and Syria was ruled by Assyria for the next three centuries, until the late 7th century BCE, and was still known as Eber-Nari and Aram throughout the period. It is from this period that the name "Syria" first emerges, but not in relation to "modern Syria", but as an Indo-European corruption of "Assyria", which in fact encompassed the modern regions of northern Iraq, north east Syria, south east Turkey and the northwestern fringe of Iran. (see Etymology of Syria)
After this empire finally collapsed, Mesopotamian dominance continued for a time with the short lived Neo-Babylonian Empire (612–539 BCE), which ruled the region for almost 75 years.
Classical antiquity.
Persian Syria.
In 539 BCE, Cyrus the Great, King of Achaemenid Persians, took Syria as part of his empire. Due to Syria's location on the Eastern Mediterranean coast, its navy fleet, and abundant forests, Persians showed great interest in easing control while governing the region. Thus, the indigenous Phoenicians paid an annual tribute of only 350 talent compared to Egypt's tribute of 700 talents. Furthermore, Syrians were allowed to rule their own cities, in that they continued to practice their native religions, establish their own businesses, and build colonies all over the Mediterranean coast. Syria's satraps used to reside in Damascus, Sidon or Tripoli.
In 525 BCE, Cambyses II managed to conquer Egypt after the Battle of Pelusium. Afterwards, he decided to launch an expedition towards Siwa Oasis and Carthage, but his efforts were in vain as Phoenicians refused to operate against their kindred.
Later on, Phoenicians contributed dearly to Xerxes I's invasion of Greece. Arwad aided the campaign with its fleet, while land troops helped in constructing a bridge for Xerxes's army to cross the Bosphorus into mainland Greece.
During Artaxerxes III's reign (358-338 BCE), Sidon, Egyptians, and eleven other Phoenician cities started to revolt against the Persian rulers. The revolutions were heavily suppressed in that Sidon was burnt with its citizens.
Hellenistic Syria.
 
Persian dominion ended with the conquests of the Macedonian Greek king, Alexander the Great in 333–332 BCE after the Battle of Issus which took place south of the ancient town Issus, close to the present-day Turkish town of Iskenderun. Syria was then incorporated into the Seleucid Empire by general Seleucus who started, with the Seleucid Kings after him, using the title of "King of Syria". The capital of this Empire (founded in 312 BCE) was situated at Antioch, then a part of historical Syria, but just inside the Turkish border today as well.
A series of six wars, Syrian Wars, were fought between the Seleucid Empire and the Ptolemaic Kingdom of Egypt, during the 3rd and 2nd centuries BCE over the region then called Coele-Syria, one of the few avenues into Egypt. These conflicts drained the material and manpower of both parties and led to their eventual destruction and conquest by Rome and Parthia. Mithridates II, King of Parthian Empire, extended his control further west, occupying Dura-Europos in 113 BCE.
By 100 BCE, the once formidable Seleucid Empire encompassed little more than Antioch and some Syrian cities. In 83 BCE, after a bloody strife for the throne of Syria, governed by the Seleucids, the Syrians decided to choose Tigranes the Great, King of Armenia, as the protector of their kingdom and offered him the crown of Syria.
Roman Syria.
The Roman general Pompey the Great captured Antioch in 64 BCE, turning Syria into a Roman province and ended Armenian rule, establishing the city of Antioch as its capital.
Antioch was the third largest city in the Roman Empire, after Rome and Alexandria, with an estimated population of 500,000 at its zenith, and being a commercial and cultural hub at the region for many centuries later. Syria's large and prosperous population made it one of the most important Roman provinces, particularly during the 2nd and 3rd centuries CE. In the course of the second century AD, the cities of Palmyra and neighboring Emesa (modern-day Homs) rose to wealth and prominence and both would be notably active in the third century, both in resisting the Parthian Empire but also in raising up Roman usurpers.
Under the Severan dynasty, Syrian nobles administered Rome and even rose to imperial title, such as the matriarch of the family, Julia Domna, who descended from the Emesan dynasty of priest-kings of Elagabalus and who married Septimius Severus in 187. After the ascension of Domna's two sons to the throne and their eventual death, the Severan dynasty was usurped by Macrinus, a prominent figure in Roman court and a Praetorian prefect. Domna's sister Julia Maesa returned to Emesa, taking her enormous wealth, and her two daughters and grandsons with her. Back in Emesa, her grandson, Elagabalus. Soldiers from Legio III Gallica who were stationed near Emesa would visit the city occasionally, and were persuaded to swear fealty to Elagabalus by Maesa who used her enormous wealth and claimed that he was Caracalla's bastard. Elagabalus later rode to battle against Marcinus, and entered the city of Antioch emerging as emperor, with Marcinus fleeing before being captured near Chalcedon and executed in Cappadocia. Whatsoever, his reign lasted only a short 4 years, filled with sex scandals, eccentricity, decadence, and zealotry. Realizing that the popular support for the emperor was fading, Julia Maesa decided to replace him with her younger grandson, his cousin Severus Alexander, and convinced Elagabalus to name him as his heir and give him the title of "Caesar", but after revoking his far more popular cousin of his titles and ranks, and reversing his consulships, the Praetorian guard cheered on Alexander, naming him emperor and slaying Elagabalus and his mother. Severus Alexander's rule was longer, and unlike Elagabalus' disastrous rule, was filled with domestic achievements and he earned the popularity and respect of his people, something Elagabalus never had. He ruled for 13 years, before eventually losing the popularity he once had and being slain by the Legio XXII Primigenia.
Another Emperor of Syrian origin was Philip the Arab, born in modern-day Shahba, he reigned from 244 to 249. His reign enjoyed relative stability, he maintained good relations with the senate, reaffirmed old Roman virtues and traditions, and started many building projects, most popularly in his hometown, renaming it Philippopolis, and raising it to civic status. Whatsoever, the creation of a new city, alongside the massive tribute to the Persians, he had to raise taxes to high levels and stop paying subsidies to the tribes north of the Danube, which were essential to keeping the peace with them. Nonetheless, his reign ended shortly after Decius usurped the throne, killing Philip and emerging as the new emperor.
During the Roman–Sasanian war of the 3rd century, the Romans, struggling in the early stages of the Crisis of the Third Century depended on Odaenathus, the King of the Syrian city-state of Palmyra to secure the Roman East from the Persian invaders and to regain lost Roman territories, so Odaenathus rode north leading the Palmyrene army, and regained Armenia, Northern Syria, parts of Asia Minor from the Persians, and even reached the Persian capital of Ctesiphon, thus weakening the Persians and securing the Roman East, before he was murdered by his own nephew, Maeonius.
Years later, Palmyra rose in rebellion against the Roman Empire under the leadership of Zenobia, Odaenathus' widow and Queen Mother of Palmyra, who led her armies to conquer Syria, Asia Minor, Arabia and Lower Egypt in a series of campaigns in which she annexed almost the entire Roman east, all while the Roman Empire was struggling during the Crisis of the Third Century, ruled by incompetent emperors and torn apart by civil war. Whatsoever, the Palmyrene Empire was short lived; once the Roman general Aurelian rose to power, he rode east, defeated Queen Zenobia in battle twice, and rode to Palmyra to reconquer it and subsequently sacked it around 273 CE, which effectively put an end to Palmyrene civilization.
With the decline of the empire in the west, Syria became part of the Eastern Roman, or Byzantine,