Georg Nagel (born 24 August 1953 in Weingarten, Germany) is a biophysicist and professor at the Department for Neurophysiology at the University of Würzburg in Germany. His research is focused on microbial photoreceptors and the development of optogenetic tools.
Scientific career.
Georg Nagel studied biology and biophysics at the University of Konstanz, Germany. He received his PhD from the University of Frankfurt in 1988, working at the Max Planck Institute of Biophysics in Frankfurt. As a postdoc, he worked at Yale University and Rockefeller University, US. From 1992 to 2004, he headed an independent research group in the Department of Biophysical Chemistry at the Max Planck Institute of Biophysics in Frankfurt. Since 2004, he is a professor at the University of Würzburg, Germany, first at the Department for Molecular Plant Physiology and Biophysics, since 2019 at the Department for Neurophysiology.
Research.
Georg Nagel, together with Peter Hegemann, is credited with the discovery of channelrhodopsins, which opened the new field of optogenetics. Early in 1995, Georg Nagel and Ernst Bamberg demonstrated that a microbial rhodopsin (Bacteriorhodopsin), when expressed in animal cells ("Xenopus" oocytes), is fully functional and makes the cells light-sensitive. In 2003, Nagel showed the functionality of channelrhodopsin-2 (ChR2) in a mammalian cell line, where illumination with blue light caused a strong depolarization of the membrane potential. Following this proof-of-principle publication, ChR2 was expressed in hippocampal neurons in collaboration with Karl Deisseroth, where light pulses caused action potentials with high temporal precision. The first application of optogenetics in an intact animal, the round worm "Caenorhabditis elegans", published 2005 by Georg Nagel and Alexander Gottschalk, was based on a ChR2 mutant (H134R) Nagel had created to improve photocurrents. The first successful optogenetic inhibition of neuronal spiking (2007) was based on Nagel's earlier experiments with halorhodopsin from "Natronomonas pharaonis". In 2007, in another collaboration with Peter Hegemann, Georg Nagel started the optogenetic manipulation of cAMP. In 2015, Georg Nagel and Shiqiang Gao, together with Alexander Gottschalk's group, characterized the first 8 TM enzyme rhodopsin, Cyclop, which raises the concentration of cGMP when activated with light. Through the development of genetically encoded tools, Georg Nagel's group has pushed the boundaries of optical control from ion channels and pumps to second messenger systems, and has applied them to many different types of organisms, including plants.
References.
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