British biochemist; (1914–1998)
George Joseph Popják ("György Popják"; born 5 May 1914, Kiskundorozsma, Szeged – 30 December 1998, Westwood, Los Angeles) was a Hungarian-British biochemist, medical researcher, and medical school professor.
Biography.
George Joseph Popják, whose father was a civil engineer, studied medicine at Franz Joseph University. There he received in 1938 his medical doctorate "Sub Auspices Gubernatoris" in a special ceremony presided over by a representative of the head of state. The special ceremony, attended by many prominent citizens, began by the university choir singing the national anthem of Hungary, then Popják gave a scientific presentation and was given a special diploma and a gold ring. After graduating with his medical degree, he worked as an anatomy assistant at Franz Joseph University before beginning further training as a pathologist.
Shortly before the start of WW II, Popják left Hungary and went to London on a British Council scholarship. In 1941 George and Hasel Popják were married. After two years as a research assistant in the Department of Pathology of Hammersmith Hospital's Postgraduate Medical School, he was appointed as a lecturer in the Department of Pathology at St Thomas' Hospital Medical School. In 1947 he moved to the National Institute for Medical Research in Mill Hill. From 1953 to 1962 he was the director of the Experimental Radiopathology Research Unit of the Medical Research Council, based at Hammersmith Hospital. From 1962 to 1968 Popják and John W. Cornforth were the co-directors of the Chemical Enzymology Laboratory at Shell Research in Sittingbourne. In 1968 Popják moved to the University of California, Los Angeles (UCLA), where he worked as a professor of biological chemistry and psychiatry. After his retirement in 1984, he continued to do research in the Atherosclerosis Research Unit of UCLA's medical department until shortly before his death. Upon his death he was survived by his widow, who died in 2004 at age 93.
Research.
George Joseph Popják, who published around 230 scientific publications during his career, began his biochemical research into lipid metabolism in the 1940s, particularly the biosynthesis of sterols and other lipids. From the early 1950s onwards he concentrated on the investigation of cholesterol biosynthesis. In doing so he used substrates that were radioactively labelled at defined molecular positions.
In this way and through enzymological methods he was able to elucidate the individual reaction steps in the formation of cholesterol together with Konrad Bloch, Feodor Lynen and especially with John W. Cornforth, with whom he worked extensively from 1948 to 1968. In addition, Popják demonstrated that fatty acid synthesis does not take place in the mitochondria as a reversal of β-oxidation, but is based on an independent enzyme system in the cytosol. After moving to UCLA he focused primarily on the regulation of cholesterol biosynthesis.