Enzyme
The enzyme propanediol dehydratase (EC 4.2.1.28) catalyzes the chemical reaction
propane-1,2-diol formula_1 propanal + H2O
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is propane-1,2-diol hydro-lyase (propanal-forming). Other names in common use include meso-2,3-butanediol dehydrase, diol dehydratase, -1,2-propanediol hydro-lyase, diol dehydrase, adenosylcobalamin-dependent diol dehydratase, propanediol dehydrase, coenzyme B12-dependent diol dehydrase, 1,2-propanediol dehydratase, dioldehydratase, and propane-1,2-diol hydro-lyase. This enzyme participates in glycerolipid metabolism. It employs one cofactor, cobamide.
Structural studies.
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1DIO, 1EEX, 1EGM, 1EGV, 1IWB, 1UC4, and 1UC5.
References.
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