Protein-coding gene in the species Homo sapiens
Sialidase-1, is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the "NEU1" gene.
Function.
The protein SIALIDASE-1 encoded by the NEU-1 gene encodes the lysosomal enzyme SIALIDASE-1, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.
Clinical significance.
Mutations in "NEU1" leads to sialidosis, a rare lysosomal storage disease. Sialidase has also been shown to enhance recovery from spinal cord contusion injury when injected in rats.
Interactions.
NEU1 has been shown to interact with Cathepsin A.
References.
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Further reading.
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