Protein-coding gene in humans
Human chromosome X open reading frame 58 (CXorf58) is a protein coding gene encoding the CXorf58 protein.
Gene.
CXorf58 contains 9 exons. CXorf58 is 31,578 nucleotides long. The longest exon in CXorf58 is exon 1, containing 324 nucleotides and the shortest exon is exon 4, containing 111 nucleotides. CXorf58 is highly expressed in sperm cells, particularly at the lower point of the head and midpiece of spermatids.
Isoforms.
There are two isoforms for CXorf58 protein. Isoform 1 for CXorf58 is 332 amino acids long and isoform 2 is 330 amino acids long. Isoform 2 uses an alternate in-frame splice site in the 3' coding region, resulting in a shorter protein.
Protein.
The molecular weight of CXorf58 isoform 1 protein is 38.9kDa. It is rich in basic amino acids and abundant in the amino acids methionine and arginine. CXorf58 contains 3 asparagine-linked glycosylation sites and 5 phosphorylation sites.
Gene level regulation.
CXorf58 contains a tissue-specific expression pattern. It is found in high abundance in the testis.
Protein level regulation.
CXorf58 is localized in the cytoplasm of cells. CXorf58 contains 10 net phosphorylation sites. There is one glycosylation site for CXorf58 at amino acid 320.
Homology.
Orthologs of CXorf58 appear in an array of taxonomic groups.
Interacting proteins.
Five proteins have interactions with CXorf58: GDE1, H2BC9, HOXA1, TGFBR2, and DCAF5.
Clinical significance.
Mutations that occur on CXorf58 include deletions of base pairs, missense mutations, nonsense mutations, and frameshift mutations. Many of which are coding sequence variants.
References.
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