Protein-coding gene in the species Homo sapiens
Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the "MLKL" gene.
Function.
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. 
Influence in diseases.
High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]. A unique neurodegenerative disease has been reported in association with a homozygous frameshift mutation, rs561839347, in "MLKL" that causes replacement of part of the C-terminal pseudokinase domain with a 21-residue sequence of random amino acids.
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."