Chemical compound
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5-Fluoro-α-methyltryptamine (5-Fluoro-αMT, 5F-AMT), also known as PAL-212 or PAL-544, is a putative stimulant, entactogen, and psychedelic tryptamine derivative related to α-methyltryptamine (αMT).
It has been found to act as a fairly balanced serotonin-norepinephrine-dopamine releasing agent (SNDRA), as a serotonin 5-HT2A receptor agonist, and as a potent and specific MAO-A inhibitor. Its EC50Tooltip half-maximal effective concentration values in terms of monoamine release are 14 to 19nM for serotonin, 78 to 126nM for norepinephrine, and 32 to 37nM for dopamine. Its EC50 at the serotonin 5-HT2A receptor is 8.47nM and its EmaxTooltip maximal efficacy at the receptor is 107%.
The IC50Tooltip half-maximal inhibitory concentration of 5-fluoro-AMT for MAO-A is 180 to 450nM. This is similar to the potency of "para"-methoxyamphetamine (PMA) and 4-methylthioamphetamine (4-MTA).
The potent serotonin 5-HT2A receptor agonism of 5-fluoro-αMT suggests that it could be an active psychedelic in humans, although it is not known to have been tested in humans and could be dangerous due to its strong inhibition of MAO-A. Accordingly, 5-fluoro-αMT induces the head-twitch response, a behavioral proxy of psychedelic-like effects, in rodents.
References.
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Further reading.
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