In enzymology, a methionyl-tRNA formyltransferase (EC 2.1.2.9) is an enzyme that catalyzes the chemical reaction
10-formyltetrahydrofolate + -methionyl-tRNAfMet + H2O formula_1 tetrahydrofolate + "N"-formylmethionyl-tRNAfMet
This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. This enzyme participates in three metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.
Structural studies.
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1FMT and 2FMT.
References.
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