The 3′ UTR of mRNA "hilD", a master regulator of "Salmonella" pathogenicity island 1 (SPI-1), is a prokaryotic example of functional 3'UTR. The 3'UTR is a target for "hilD" mRNA degradation by the degradosome and it may play a role in "hilD" and SPI-1 expression by serving as a target for the Hfq RNA chaperone. Under non-invasive conditions it is necessary to keep low levels of SPI-1 expression. It plays a role in S. Typhimurium virulence as a regulatory motif.
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