The enzyme aminoacyl-tRNA hydrolase (EC 3.1.1.29) catalyzes the reaction
"N"-substituted aminoacyl-tRNA + H2O formula_1 "N"-substituted amino acid + tRNA
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name is aminoacyl-tRNA aminoacylhydrolase. Other names in common use include aminoacyl-transfer ribonucleate hydrolase, "N"-substituted aminoacyl transfer RNA hydrolase, and peptidyl-tRNA hydrolase.
Structural studies.
As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1RYB, 1WN2, 1XTY, 2D3K, 2E1B, 2PTH, 2Z2I, 2Z2J, and 2Z2K.
References.
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