Protein-coding gene in the species Homo sapiens
Regulator of G-protein signaling 20 is a protein that in humans is encoded by the "RGS20" gene.
Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins are GTPase-activating proteins for Gi (see GNAI1; MIM 139310) and Gq (see GNAQ; MIM 600998) class G-alpha proteins. They accelerate transit through the cycle of GTP binding and hydrolysis and thereby accelerate signaling kinetics and termination.[supplied by OMIM]
In melanocytic cells RGS20 gene expression may be regulated by MITF.
Interactions.
RGS20 has been shown to interact with GNAO1 and GNAZ.
References.
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Further reading.
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