Protein-coding gene in the species Homo sapiens
Cytoskeleton-associated protein 5 is a microtubule-associated protein that in humans is encoded by the "CKAP5" gene. It is the homolog of the "Xenopus" protein XMAP215 and is also known as ch-Tog.
It has at least two distinct roles in spindle formation: it protects kinetochore microtubules from depolymerization by MCAK (KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.
Interactions.
CKAP5 has been shown to interact with TACC1.
References.
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Further reading.
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