Protein-coding gene in the species Homo sapiens
Rhomboid-related protein 2 is a protein that in humans is encoded by the RHBDL2 gene.
Function.
The protein encoded by this gene is a member of the rhomboid protease family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid-1. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. 
RHBDL2 functions as a sheddase and is localized to the plasma membrane. Known substrates of RHBDL2 include thrombomodulin and epidermal growth factor; profiling of the substrate repertoire of RHBDL2 has identified a number of additional type I membrane proteins substrates, including BCAM, SPINT1, and CLCP1.
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."