Protein-coding gene in humans
Dpy-19-like 2 (C. elegans) is a protein that in humans is encoded by the DPY19L2 gene.
Function.
The "C. elegans" gene "dpy-19" belongs to the dpy ("dumpy" phenotype)
gene class and encodes DPY-19, transmembrane protein with C-linked mannosyltransferase activity.
In humans, it is highly expressed in testis, and is required for sperm head elongation and acrosome formation during spermatogenesis. Mutations in this gene are associated with an infertility disorder, spermatogenic failure type 9 (SPGF9).
References.
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Further reading.
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"This article incorporates text from the United States National Library of Medicine, which is in the public domain."