Progestin and adipoQ receptor family member 3 (PAQR3), or Raf Kinase Trapping to Golgi apparatus (RKTG) is a protein that in humans is encoded by the PAQR3 gene. It is a member of the progestin and adipoQ receptor (PAQR) family.
PAQR3 is predicted to have seven transmembrane helices and to be localized to the Golgi Apparatus. It functions as a tumor suppressor by negatively regulating tumor cell proliferation and migration by inhibiting Raf kinase and AKT pathway. PAQR3 was also shown to modulate cholesterol homeostasis by anchoring the SCAP/SREBP complex to the Golgi under cholesterol depletion conditions.
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