Spatacsin is a protein that in humans is encoded by the "SPG11" gene.
Function.
Spatacsin, in combination with the SPG15 protein, attaches the AP5 adaptor complex to the outside of late Endosomes or Lysosomes when the protein via which it binds is in a particular state.
Pathology.
Mutations of the SPG11 gene cause a rare form of spastic paraplegia, spastic paraplegia type 11.
References.
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Further reading.
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