Class of enzymes
L-2-hydroxycarboxylate dehydrogenase (NAD+) (EC 1.1.1.337, "(R)-sulfolactate:NAD+ oxidoreductase", "L-sulfolactate dehydrogenase", "(R)-sulfolactate dehydrogenase", "L-2-hydroxyacid dehydrogenase (NAD+)", "ComC") is an enzyme with systematic name "(2S)-2-hydroxycarboxylate:NAD+ oxidoreductase". This enzyme catalyses the following chemical reaction
 (2S)-2-hydroxycarboxylate + NAD+ formula_1 2-oxocarboxylate + NADH + H+
The enzyme from the archaeon "Methanocaldococcus jannaschii" uses as a substrate multiple (S)-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)-malate, (S)-lactate, and (S)-2-hydroxyglutarate.
References.
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