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Chemical compound
Pinolenic acid (often misspelled as pinoleic acid) is a fatty acid contained in Siberian Pine nuts, Korean Pine nuts and the seeds and xylem of other pine ("Pinus") species. The highest percentage of pinolenic acid is found in Siberian pine nuts and the oil produced from them.
Chemistry and biochemistry.
Pinolenic acid is formally designated as "all-cis-5,9,12-18:3". Some sources also use the term columbinic acid for this substance. But "columbinic acid" sometimes designates an E-Z isomer ("trans","cis","cis"
"delta"-5,9,12/18:3) in the biologic literature.
Pinolenic acid is an isomer of gamma-linolenic acid (GLA). GLA is an ω-6 essential fatty acid (EFA) but pinolenic acid is not. However, like the EFAs, it forms biologically active metabolites in the presence of cyclooxygenase or lipoxygenase. These metabolites can partially relieve some of the symptoms of EFA deficiency.
Physiology.
Recent research has shown its potential use in weight loss by curbing appetite.
Pinolenic acid causes the triggering of two hunger suppressants—cholecystokinin and glucagon-like peptide-1 (GLP-1).
Pinolenic acid may have LDL-lowering properties by enhancing hepatic LDL uptake.