The 2020–21 season is the 50th season in CFR Cluj's history, and the 25th in the top-flight of Romanian football. CFR Cluj is competing in Liga I and the Cupa României, having also competed in the Champions League and UEFA Europa League.
 "As of 10 March 2021"
Players.
First-team squad.
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Transfers.
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Overall transfer activity.
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Preseason and friendlies.
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Competitions.
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Liga I.
The Liga I fixture list was announced in August 2020.
Regular season.
Matches.
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Championship round.
Matches.
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Cupa României.
CFR Cluj entered the Cupa României at the Round of 32.
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Supercupa României.
CFR Cluj will play in the Romanian Supercup as winners of the Liga I against Cupa României winners FCSB.
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UEFA Champions League.
As winners of the 2019-20 Liga I, CFR Cluj entered the Champions League at the first qualifying round.
First qualifying round.
The draw for the first round took place on 9 August. CFR Cluj was drawn to play against Maltese champions Floriana.
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Second qualifying round.
CFR Cluj advanced to the second qualifying round. The draw for the second round took place on 10 August. CFR Cluj was drawn to play against Croatian champions Dinamo Zagreb.
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UEFA Europa League.
After losing to Dinamo Zagreb in the Champions League second qualifying round, CFR Cluj progressed to the Europa League third qualifying round.
Third qualifying round.
The draw for the third round took place on 1 September. CFR Cluj were drawn to face either the Swedish champions Djurgårdens IF or the champions of Gibraltar Europa. On 17 September Djurgårdens IF won against Europa 2−1.
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Play-off Round.
CFR Cluj advanced to the play-off round. The draw for the play-off round took place on 18 September. CFR Cluj was drawn to play against Finnish champions KuPS.
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Group stage.
CFR Cluj progressed to the Europa League group stage. The draw was held on 2 October. CFR Cluj was drawn with Roma, Young Boys and CSKA Sofia.
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 "As of 18 May 2021"
Statistics.
Squad statistics.
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Last updated: 25 May 2021Source: Competitive matches
 "As of 25 May 2021"
Goal minutes.
Last updated: 25 May 2021 
Source: Soccerway
 "As of 25 May 2021"
References.
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