The 2020–21 season was Ludogorets Razgrad's tenth consecutive season in the Bulgarian First League, of which they were defending champions.
Season events.
On 21 July, midfielder Serkan Yusein joined CSKA 1948 on loan for the season.
On 23 July, Ludogorets announced the signing of Alex Santana from Botafogo, with Rafael Forster heading in the opposite direction.
On 24 July, Beroe Stara Zagora announced the signing of Dimo Bakalov from Ludogorets.
On 30 July, Bernard Tekpetey joined Ludogorets on loan from Schalke 04 for two seasons.
On 12 August, Ludogorets announced the signing of Higinio Marín from Numancia.
On 16 August, Ludogorets announced the signing of Elvis Manu from Beijing Renhe.
At the draw for the Third qualifying round of the 2020–21 UEFA Europa League, Ludogorets were given a bye to the Play-off Round after a draw of lots between the teams dropping into the Europa League after elimination in the 2020–21 UEFA Champions League.
On 4 September, Olivier Verdon joined Ludogorets on loan for the season from Alavés.
On 2 October, Ludogorets announced the signing of Josué Sá from Anderlecht.
On 5 October, Kiril Despodov joined on loan from Cagliari for the duration of the season.
On 26 October, manager Pavel Vrba resigned from his position, with Stanislav Genchev being appointed as interim-manager in his place.
On 12 November, Jorginho was loaned to Wadi Degla until July 2021, with an option to make the move permanent.
On 3 January, Valdas Dambrauskas was announced as Ludogorets Razgrad's new Head Coach.
On 2 February, Júnior Brandão joined Rio Ave on loan until the end of the season.
On 5 February, Ludogorets Razgrad announced the signing of Pieros Sotiriou from Astana.
On 1 March, Ludogorets Razgrad announced the signing of Kristijan Kahlina on loan from HNK Gorica.
 "As of match played 26 May 2021"
Squad.
Out on loan.
 ;templatestyles src="Template:Football squad player/styles.css" / ;
Friendlies.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Competitions.
Bulgarian Supercup.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
A Football Group.
Regular stage.
Results.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Championship stage.
Results.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Bulgarian Cup.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
UEFA Champions League.
Qualifying rounds.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
UEFA Europa League.
Qualifying rounds.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
Group stage.
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 ;templatestyles src="Template:Football_box_collapsible/styles.css" / ;
 "As of match played 26 May 2021"
References.
 ;templatestyles src="Reflist/styles.css" / ;