Ankhefensekhmet "(ˁnḫ=f n sḫm.t;" "He lives for Sekhmet") was a High Priest of Ptah during the 21st Dynasty in Egypt. He probably served during the reign of Psusennes II and maybe the reign of Shoshenq I.
Ankhefensekhmet is known from a genealogy known as Berlin 23673, which was made by his namesake descendant during the late 22nd Dynasty. On it, he is said to be a prophet ("hm nTr"). He is also mentioned in a genealogy from the Louvre where he is said to be a High Priest of Ptah.
Ankhefensekhmet is known to have married the Lady Tapeshenese, who served as the First Chief of the Harem of Ptah and Prophetess of Mut. She was the mother of his successor Shedsu-nefertum.
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