The 1981 NCAA Division II Lacrosse Championship was the eighth annual single-elimination tournament to determine the national champions of NCAA Division II men's college lacrosse in the United States.
This would be the final edition of the Division II men's tournament until 1993.
The final, and only match of the tournament, was played at Motamed Field at Adelphi University in Garden City, New York. 
Hosts Adelphi defeated Loyola (MD), 17–14, to win their second national title. Paul Doherty coached the Panthers (10–2). This was Adelphi's second title in three seasons.
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