The 2005 season for Quick-Step–Innergetic began in January at the Tour Down Under.
Three riders announced their retirements from cycling in 2004. Johan Museeuw made 2004 his last year of professional racing after riding for the team for 2003, 2004 and with the team's predecessor Mapei–Quick-Step for 6 years. Richard Virenque seven-time winner of the Mountains classification in the Tour de France also retired, he won the last two of his seven victories at Quick-Step. Laurent Dufaux Two-time winner of the Critérium du Dauphiné also retired at the end of 2004 after one year with the team.
 "As of "
2005 roster.
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One-day races.
The one-day race season for QuickStep started at the Doha International GP in January. It wasn't until Gran Premio di Lugano in February where the team would get their first victory. Rik Verbrugghe won the race from a breakaway sprint against Patrice Halgand.
Quick-Step went 1st and 2nd at this years edition of Omloop Het Volk with Nick Nuyens attacking with 15 km to go and holding a 14-second lead to the line. Then Tom Boonen managed to sprint the rest of the peloton to gained 2nd in the race.
Other victories of the season included Pozzato at the Giro del Lazio and Bettini at Züri Metzgete.
Spring classics.
The Spring classic started off with Milan–San Remo in March. With 10 km before the start of the final climb Il Poggio Bettini came to the front of the bunch and put in a hard effort to create a gap. This forced Fassa Bortolo to chase and do the work allowing Boonen to stay tucked out of the wind. Shortly after Kashechkin made it across to Bettini helping him to gain a 15-second advantage on the peloton this soon rose to 30 seconds with only Fassa Bortolo doing any work at the front. As the Duo reached the base of the Poggio their lead was back down to 15 seconds. As the riders climbed attacks were launched and the duo absorbed. With 2 km to go the riders were all back together with Fassa Bortolo driving the pace for Petacchi. Bettini launched his leadout with 600m to go Petacchi took his wheel then sailed past to win by two bike lengths. Boonen ended up with the best result for the team finishing 8th his best result to date.
The second classic of spring was E3 Prijs Vlaanderen. Boonen had won this race in 2004 so he was the faverourite for this edition. The race started with an 11-man break going up the road, Kevin Hulsmans was in the break for the team. This allowed the team to not work so much in the early kilometers. With 64 km to go and with Bramati and Cretskens driving the pace the breakaway had a one-minute advantage. Soon after an attack was launched containing 6 riders including Boonen and Andreas Klier. It didn't take the 6 long to catch the breakaway out in front, due to a train crossing the peloton got within 10 seconds of the now 17 strong breakaway. With 57 km to go and starting to climb the Taaienberg Klier attacked with Boonen sticking right on his wheel. The pair managed to hold the gap to the rest of the breakaway and at 50 km to go they had 30 seconds. On the top of the Knokteberg with 27 km to go the pair now held a 22-second advantage on the remaining 5 riders in the chase group. As the race continued the time gap reduced to 11 seconds with 19 km to go. At the base of the final climb the Tiegemberg, Boonen and Klier had 20 seconds in hand over the chase group. With two kilometers the duo had secured podium places holding 30 seconds over Peter van Petegem and the chase group behind. With Boonen accelerating from behind Klier with 200m to go he secured his second consecutive victory in the race.
The third classic for this season was the Tour of Flanders. The Team took Boonen as their sprinter for the race although the last few editions had been won by a breakaway. The team had planned to bring Bettini but he came down with mononucleosis. It took a while for the first break of the day to form, no riders from the team were present they were going all in to bring Boonen to the sprint. On climb number 10 with the team leading the peloton Ballan launched an attack which Quick-Step tried to cover but Ballan made it across to solo leader Zaballa. By climb 11 the duo had 45s on the Quick-Step led peloton. On climb 14, Boonen, Klier and Van Petegem bridged across to Petito and Zabel, with Ballan still out in front. Those six riders were riding flat out and essentially the race would be decided between them. Discover-Channel tried their best to tow the peloton back up but with Quick-Step, T-Mobile, Fassa Bortolo and Lotto not contributing the peloton had a very slim chance. With 10 km to go the 6 riders were still together, Van Petegem then attacked with Boonen countering. Van Petegem looked back to see if others would chase but they hesitated. No one expected sprinter Boonen to attack, he quickly gained 50 meters. With 5 km to go Boonen held a very slim 10s over the chasers. As Boonen rounded the final corner he had enough time to raise his hands and celebrate his victory.
This years Gent–Wevelgem was 208 km in length, the team bought Boonen with them as their main man. After winning E3 and being the winner last year, Boonen was the faverourite to win. With 85 km to ride a group of 30 went up the road containing: Boonen, Cretskens, Hulsmans and Knaven. As the race continued the group managed to gain 1 minute on the chasers with Boonen driving the pace at the front. With 41 km to go Flecha attacked Boonen was unable to follow but Pozzato was able to. With 25 km to go the Pozzato group had 20s on the Boonen group. Boonen sat up back into the peloton hoping the peloton would catch and he could win the sprint. Meanwhile, Pozzato was looking strong coming into the final 7 km until a crash on a corner took him out of contention. With the peloton not catching the breakaway Boonen finished 26th in the sprint.
The 'Hell of the North' this year would be ridden without 'The Lion of Flanders' who retired at the end of last year. After his impressive Tour of Flanders win Boonen was the faverourite for Paris–Roubaix this year. With 50 km of racking to go an 11-man group had formed at the head of the race with a 2-minute advantage over the peloton. Soon after Cancellara punctured and was forced to drop back, the breakaway kept on riding with Boonen pushing the pace. With just over 10 km to go Boonen increased the pace dropping everyone except George Hincapie and Juan Antonio Flecha. With 5 kilometers to go no one was attacking the chasers were 40s back with the cancellara group 3 minutes down and the peloton a further minute behind. The three-man sprint was launched by Flecha with 250m to go with Boonen coming down the banking to take victory and Hincapie giving it all to take second. This victory means Boonen became the 9th cyclist to win Tour of Flanders and Paris Roubaix in the same year. With the previous two being Peter Van Petegem in 2003 and Roger De Vlaeminck in 1977.
In the Dutch classic, The Amstel Gold Race, Patrik Sinkewitz managed to stay with the front runners the whole race and ended up sprinting for eighth.
Trying to improve on last years 21st position Sinkewitz lead the team in this years edition of La Flèche Wallonne. With 32 km left to race Rik Verbrugghe attacked hoping to bridge up to the leaders and repeat what he did in 2001 and win the classic. He managed to catch up to one of the riders out in front but the peloton soon caught them both. The peloton was still mostly together by the time the last climb came. Di Luca attacked and managed to win the uphill sprint with Sinkewitz managing 7th just 4 seconds down.
The final Spring Classic of the year was Liège–Bastogne–Liège. The team brought 2003 winner Paolo Bettini hoping for him to repeat the feat. After 171 km of racing the breakaway had 2'40" over the peloton which was splintering due to many attacks by many riders. Bettini was one such rider. He managed to get into a chase group of 11 riders and split away from the peloton. 12 km later the chase group was down to 7 with Bettini still in contention. With 68 km to go the chase had caught the break but the peloton was only 20 seconds behind in the next 14 km many riders would jump across the gap until Rebellin pulled the two groups together making one group of 30. With 52 km to go Voigt attacked and Vinokourov followed these two would not be caught over the rest of the race. Bettini punctured over the top of La Redoute, luckily Sinkewitz was there to tow him back into contention. Cadel Evans attacked with 3 km to go he was soon joined by Bettini and Michael Boogerd, the three rode hard getting to within 40 seconds of the leaders but it was a case of too little too late. Evans attacked on the final climb with Boogerd countering, Boogerd finished third with Bettini managing fourth.
Fall races.
The Fall classics started with Paris–Brussels where Pozzato managed an 11th in the sprint. The following month in October Pozzato managed 14th in Paris–Tours. None of the other Fall classics provided great results except for Giro di Lombardia; where Bettini took a sprint victory from companions Gilberto Simoni and Fränk Schleck. This was the first victory of the Team in this race, although it was won in 1998 by the team's predecessor Mapei–Bricobi.
Stage races.
The Tour Down Under was the first race that Quick-Step raced in 2005. The best result achieved by a rider was Dimitri De Fauw who placed 9th in the first stage in the bunch sprint.
February brought the second stage race of the season for the team the Tour of Qatar. Tom Boonen was the rider Quick-Step were in Qatar to support. He opened his season by taking Stage 1 beating Mario Cipollini and Robbie Hunter to the line. Boonen added to his tally by also taking Stage 2 from a reduced sprint of 18 riders this time beating Fabrizio Guidi and Robbie McEwen. By winning the first two stages and 9th, 2nd and 3rd in the remaining stages Boonen was able to win the Points classification by 50 points to McEwen. He also managed 4th Overall in the race and 2nd in the Youth classification.
Paris–Nice was the first race of the 2005 UCI ProTour. Quick-Step took Boonen for the sprints and World time-trial champion Michael Rogers for the Overall contention. The Tour opened with a 4 kilometer prologue with Rogers finishing 6 seconds down in 10th position. Stage 1 Boonen was considered the absolute favorite based on his results at the Tour of Qatar last month. During stage 1 the peloton suffered a crash which caused a split with 10 kilometers to go resulting in 23 riders being off the front. This bunch was led by Quick-Step who pulled the gap out to 41 seconds by the finish line they also delivered the win to Boonen who out sprinted Luciano André Pagliarini and Jaan Kirsipuu. Stage 2 was shortened to 46.5 kilometers after snow blocked the original route. Boonen too his fourth victor of the season in another bunch sprint. This gave him enough bonus seconds to take the leaders yellow jersey and also the points classification. With Stage 3 having another up hill finish Boonen looked poised to take a third win in a row. However, when it came down to the sprint with 400m to go Boonen was blocked in and couldn't manoeuvre around Jens Voigt so had to settle for 7th on the stage. Guido Trenti was better positioned and managed to finish the stage in 2nd behind Vicente Reynés. Stage 4 had more of a hilly finish so Boonen was not considered a favorite although he did finish in the top 10, 32 seconds