The 2021–22 season was the 97th season in existence of Olympiacos and the club's 63rd consecutive season in the top flight of Greek football. Olympiacos participated in the Greek Super League winning their 47th title (3rd in a row), finishing 19 points ahead of PAOK who came second. Olympiacos also participated in this season's Greek Cup, UEFA Champions League and UEFA Europa League. During the season Pedro Martins became the longest-serving Piraeus coach in a single term. The season covers the period from July 2021 to late May 2022.
 "As of 31 January 2022"
 "As of 31 January 2022"
Transfers.
In.
 Total Spending: €12.22M
Out.
 Total Income: €11.80M
Net Income: €0.42M
Friendlies.
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Competitions.
Super League Greece.
Regular season matches.
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Play-off round matches.
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Greek Football Cup.
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Round of 16.
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Quarter-finals.
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Semi-finals.
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UEFA Champions League.
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Second qualifying round.
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Third qualifying round.
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UEFA Europa League.
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Play-off round.
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Group stage.
The group stage draw was held on 27 August 2021.
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Knockout phase.
Knockout round play-offs.
The knockout round play-offs draw was held on 13 December 2021.
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 "As of match played 17 May 2022"
 "As of match played 17 May 2022"
Squad statistics.
Goalscorers.
Own goals: 2
References.
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