c. 1530 painting by Moretto da Brescia
The Sant'Eufemia Altarpiece is a 1526-1530 oil on panel painting by Moretto da Brescia, originally on the high altar of Sant'Afra in Brescia and now in the Pinacoteca Tosio Martinengo in the town. The Sant'Afra Reliquary was also based on the painting. The painting's lower register shows saints Benedict of Nursia, Euphemia, Justina and Paterius.
In 1805 the monastery attached to Sant'Afra was suppressed and converted into a barracks and the church was made subsidiary to Sant'Afra on via Francesco Crispi (now Sant'Angela Merici), whose Fabbriceria decided to donate the painting to the Pinacoteca Tosio Martinengo in 1867 in exchange for a painting by Enea Salmeggia from the same Tosio collection.