Space is big! So the closer your world observes ours the more your answer becomes no. Basically the problem is that missile in space generally do not need explosives in them. The kinetic impact is enough. The lack of drag gives any missile a huge advantage over ships namely the have a lots of room to accelerate (because engagement distance's are large) and unless everybody was in the exact same orbit the relative velocity will just exponentially make the impact bigger. And also missiles are by definition smaller than the ships there fired from and at there is just no dodging a guided missile. And is simple a question if your counter measures are better then there's. So long range fight will be the norm in most relativistic space sages. They spot a dot on the radar they fire missiles; They observe fast moving stuff being fired back and they will probably deploy some decoys. A few hours later there might be conformation on a hit or miss.
Space bubbles is one way your setting can solve this issue of space being big. Make everyone travel faster than light in a smaller subspace. Traveling in such a subspace might require a ship to make a bubble of real-space inside this subspace, everything outside said bubbles boundary gets disintegrated. So shooting projectiles and missiles will simply be impossible unless they have there own bubble generator. 898
Perhaps ramming the front of your bubble in the side of the enemies will weaken there's more than yours perhaps forcing them back into real space. Whilst your ship can then drop a nuke 500 meter from there point of entry into real space. So other options would be.
* Colliding warp bubbles will merge into one big one. Therefore you just suddenly appear 50 meters away from there port side with some initial ramming velocity.
* Both ship appear in real space with relative speed intact so yeah the ships will collide just not at mutual disintegration speed.
I would imagine if a observer in real space would observe a battle in sub-space as follows. First contact would be the galley's when they ram each other head one and both appear in real space only 10 meter apart. After the collisions smaller corvettes might phase-in and out into reals space near those galley's to try and do hit-and runs. of course for fear of friendly fire no nukes are used. The galley's will try get clear of each other to phase back into subspace. Leaving possible nukes and mines behind. Or go for a old fashioned boarding. Ship of lines might take another approach the could try and extent there bubble and make it larger. When the bubble's collide the ship will fire a salvo of kinetic weapons then accelerate passed the other ship and phase back into subspace in a attempt to dodge counter fire. 898