3. have clinical or biochemical evidence of diminished ovarian reserve (recent shortening of cycles &lt; 24 days between menses, age &gt; 38, elevated serum FSH (follicular stimulating hormone)&gt; 15 IU/L, or low antral follicle count (AFC- number of follicles less than 10 mm on day 2 or 3 of natural menses) on baseline pelvic ultrasound (&lt;5) or elevated day 2 or 3 estradiol (&gt; 280 pmol/ml);