Each unique patient identification number will be randomised to a treatment regimen before the study starts and this information will be contained in sealed envelopes. The first dose of the study drug will be dispensed at the health clinic (for children who cannot swallow, Coartem® tablets will be dissolved, and ASAQ tablets will be crushed in minimal amounts of water and dispensed by help of a syringe or dropper). Intake will be observed for 30 minutes. If the child vomits, a resting period of 15 minutes will be observed before attempting a repeat dose. Any concomitant prescriptions will be collected at the designated pharmacy and care will be taken to ensure that the instructions on home treatment are clear to the parent/caretaker.