A sub-group of patients who provide informed consent will be enrolled in the Lumbar Puncture procedure. The procedure will be performed at the beginning of the study and at the 6 month visit. The objective will be to examine changes in CSF T and B cells and correlate them with evidence of disease activity by relapse, new MRI lesions and/or SAD. This procedure is optional for patients and will have no impact on the overall study. Patients who do decide to participate will sign an Addendum for Optional Procedure Consent Form The primary endpoint will be the number of disease-free patients, defined as patients without new lesions on brain MRI using the combined unique lesion approach (CUL), without sustained change in EDSS score over any 3-month period and without relapse. Once the last patient randomized has completed the final study visit for year 1 of the study, the data will be locked and an analysis performed on all data collected up to that point. An independent Data and Safety Monitoring Board (DSMB) will meet at initiation of the study and every 6 months thereafter until the end of the study. Members of the DSMB may unblind themselves at their discretion and the DSMB will include a statistician not directly involved in this study. If induction therapy fails to show superiority at any point, the study will be stopped.