a. Left Atrial Volume Index (LAVi) ≥ 34 ml/m² or Left Ventricular Mass Index (LVMi) ≥ 149/122 (m/w) g/m²; b. (average septal and lateral) e' < 9 cm/s or E/e' ≥ 13; f) At least 1 HF related hospitalization documented in the last year g) Patient giving informed consent, willing to be available for scheduled study follow-up visits, and able to complete all testing of the study protocol