In addition to devising the most appropriate pharmacotherapeutic regimen for the patient with type 2 diabetes, patient management is also of critical importance and is best handled by a medical care team including the physician, the pharmacist, the dietitian, and a diabetes education specialist. Ideally, a diabetes care plan should be developed with input from all medical care team practitioners and the patient. Incretin-based therapies, which include the glucagon-like peptide (GLP)-1 receptor agonist's exenatide and exenatide Long acting release (LAR), and liraglutide and the Dipeptidyl peptidase-4 (DPP-4) inhibitors sitagliptin, vildagliptin, and saxagliptin represent a new class of antidiabetic drugs. Data suggest an equal or potentially greater efficacy of incretin-based therapies to lower HbA1C compared with other antidiabetic therapies, with a low risk of hypoglycemia. Other benefits include weight reduction (GLP-1 receptor agonists) or weight neutrality (DPP-4 inhibitors).GLP-1 receptor agonists have recently been added to the ADA/EASD treatment algorithm as a tier 2 alternative to the addition of SUs or basal insulin in patients not adequately controlled on metformin plus lifestyle modification.