Treatment studies in schizophrenia Three randomized controlled treatment studies conducted over 12 weeks found 2g/day EPA significantly more effective than placebo in reducing psychopathological symptoms in individuals with schizophrenia (Peet et al., 2001; Emsley et al., 2002). Symptom improvements in those studies were both, clinically relevant and statistically significant. A dose-ranging exploratory study of the effects of EPA in individuals with schizophrenia who experienced persistent symptoms found 2 g EPA/day significantly more effective in reducing symptom scores on psychiatric rating scales than 1g and 4g EPA/day (Peet et al., 2002).