The first 3 years of life and the quality of early parent-child relations are principal building blocks for adult cognitive and emotional functioning. However, investigators have found that parents have impaired relationships with their premature infants, providing heightened stimulation to the infants at inappropriate times in hopes of increasing responsiveness to them. These dysfunctional patterns place parents at risk for negative emotions and parenting outcomes and place children at risk for emotional, behavioral, and developmental problems. Therefore, early interventions are critical to decrease the negative effects of prematurity on parenting and parent-infant interactions. Early intervention may be a critical key to future successful programs with parents and their premature infants because it is recognized that, once a trajectory of parent-infant interaction is initiated, changes are difficult to implement and even harder to sustain; this program has the potential to benefit a significant number of LBW premature infants and their parents across the country.