At M0 participants will have anthropometric and functional examinations and laboratory tests, and will follow nutritional education sessions. They will be then randomized into 3 arms: arm 1 LIPOXmax physical activity, arm 2 60% VO2max physical activity, arm 3 physical activity according to guidelines of Good Medical Practices. Participants of the arms 1 and 2 will practice under the control of a sports instructor; participants of the arm 3 will be regularly monitored by telephone. The procedure will last 5 months. At M3 and M5 anthropometric and biological examinations will be replicated and participants will answer to questionnaires on quality of life and experience of physical activity during and after the intervention.