Feasibility and sample size estimation From a recent study at a tertiary invasive centre including 380 patients with AMI, (Aberdeen AMI study, Hillis et al ESC 2006), it was found that among 219 patients EF was >45%. Among those patients E/e' >15 was found in 41 patients, and in further 48 E/e' 8-15 and left atrial volume index >32 ml/m2 was found. Thus 40% of patients with LVEF>45% would be potentially eligible. Annually 2500 patients are admitted or transferred to RH with AMI.