- Subjects with more than 5 of the following risk factors: LVEF <35%, NYHA Class III or IV, LBBB with QRS > 130 ms or QRS >150 ms, renal dysfunction (BUN >26 mg/dL / > 9.28 mmol/L), diabetes type I and II, chronic atrial fibrillation (permanent or persistent according to ESC Guideline 2016), prior MI, age >70 years, smoking today or during last 5 years.