Adverse Events All observed or volunteered adverse events, regardless of treatment group or suspected causal relationship to study drug, will be recorded. This includes symptoms thought to be related to withdrawal from nicotine. Events involving adverse drug reactions, illnesses with onset during the study, or exacerbations of pre-existing illnesses should be recorded. Exacerbation of the disease under study (type 2 diabetes), is defined as a manifestation (sign or symptom) of the illness that indicates a significant increase in the severity of the illness as compared to the severity noted at the start of the trial. It may include worsening or increase in severity of signs or symptoms of the illness, increase in frequency of signs and symptoms of an intermittent illness, or the appearance of a new manifestation/complication. Exacerbation of a pre-existing illness should be considered when a subject requires new or additional concomitant therapy for the treatment of that illness during the trial. In addition, clinically significant changes in physical examination findings and abnormal objective test findings (e.g., laboratory) should also be recorded as adverse events. For all adverse events, the investigator must pursue and obtain information adequate both to determine the outcome of the adverse event and to assess whether it meets the criteria for classification as a serious adverse event. For all adverse events, sufficient information should be obtained by the investigator to determine the causality of the adverse event (i.e., study drug or other illness). The investigator is required to assess causality.