The follow-up of patients will be 52 weeks (5 time points). At each time point, main and secondary outcomes will be evaluated. Questionnaires will be filled out by the patient, before the consultation visit. An independent person (nurse, secretary, clinical research technician..) will be available to help the patient to fill his self questionnaire and check for the accuracy of the patient answers. It is important to note no physician involved in the protocol will participate to the patient evaluation. The physician assessor will be blinded for the result of the questionnaire.