7. Power calculations It is assumed that 1-2 RE patients are diagnosed at a large epilepsy center per year. The cooperation of the study center with the other specialized centers in Germany is good. Therefore, it is expected that the majority of RE cases are transferred to or department. We estimated that 16 suitable patients can be included within the proposed inclusion period. The disease is too rare to perform power calculations (which are mainly used to limit recruitment figures). RE is an orphan disease, so even if the number of participants will not suffice to detect small to moderated differences between the two treatments, the results will provide invaluable information on the conservative treatment of the condition, e.g. in comparison to historical untreated controls.