Therefore, given the current inadequacies in the state of art of defining GTV and CTV in prostate cancer, we propose a study on prostate visualisation using the latest anatomical and biological (metabolic) imaging modalities. Combining the information of different imaging techniques by introducing a BTV and through image fusion is likely to improve CTV and GTV delineation. This will allow us to redefine the choice of margins. Finally, this will result in an improved IMRT plan, where dose painting and dose escalation of the GTV is the ultimate goal. This complies with the current opinion on radiation development. Progress in functional imaging is likely to provide the tools required for individualised risk-adapted radiotherapy.