- patients with malignant or severe heart disease (uncontrolled angina and/or myocardial infarction, congestive heart failure within 3 months before recruiting, etc.), lung disease (respiratory failure), kidney (Cr, BUN 2 times more than normal ceiling), pancreatic, liver disease(severe liver function damage 2 times more than normal ALT, AST, TBIL cap) or other diseases that researchers evaluated as affect the judgment of the treatment;