SGA will be performed at -4, 0, 12, 24, 36 and 52 weeks by a single observer. The 4-item 7-point scoring system proposed by Enia et al [39] will be used. MIS will be performed at -4, 0, 12, 24, 36 and 52 weeks. The calculation of MIS has been described previously [40]. Briefly, MIS consists of 4 main parts and 10 components, all scored from 0 (normal) to 3 (very severe). The total score ranges from 0 to 30.