Study design The study involved 82 high-risk hypertensive patients (44 men and 38 women), aged 28-74years, conducted between July 2015 and February 2017 in the Department of Hypertension at the University of Medical Sciences in Poznan. Seventeen patients reported resignation during the study. The permission no. 377/15 to conduct the study was published by the Ethics Committee at the Poznan University of Medical Sciences. All the patients gave informed consent for participation in the study. Patients with primary hypertension and high cardiovascular risk were randomly assigned to one of two groups. Group 1(ASA) included 33 patients who received acetylsalicylic acid at a dose of 75 mg in the morning. Group 2 (STE) included 32 patients receiving standardized tomato extract (STE) (ZAAX, Sequia, Poland) at a dose of 213 mg orally in the morning.