- Cardiac: Have a serious cardiac condition, such as myocardial infarction within 6 months, angina, or heart disease, as defined by the New York Heart Association Class III or IV. Patients with a QTcB prolongation >450/470 msec (males/females) and patients who have a congenital long-QT-syndrome in their own or family medical history should be excluded at the investigator's discretion. Patients with intraventricular conduction delays (for instance, right or left bundle branch blocks) should also be excluded.