Musculoskeletal disorders and disability are very common in diabetes and are associated with worse glycemic control and more complications. Assessment of musculoskeletal disorders among diabetes should include an estimate of cholesterol, glycemic control, pain, respiratory parameters and quality of life. People with diabetes are twice at risk of suffering from premorbid depression as the general population. The coexistence of depression in people with diabetes catalyses serious disease comorbidities, MSK complications, decreased respiratory capacity, poor glycemic control which may lead to hyperlipidemia and poor quality of life and escalated healthcare expenditures.