During the surgical phase of the study, all of the participants will undergo respective oral and maxillofacial surgical procedure, under general anesthesia. The surgical part of this investigation will not, in any way or form, be different than the usual standard of care followed by the department of oral and maxillofacial surgery department, at Massachusetts General Hospital. Peri-operative and post-operative analgesic regimens will also be standardized as per departmental guidelines for the respective surgical procedures.