Patient Adherence Adherence with taking supplementation will be checked at each visit during active therapy and again at the 3, 6, and 9-month visits. Subjects will be provided with a data sheet to log days when they have missed taking supplements. In addition, one cryogenic vial containing a minimum of 500ul plasma will be archived at baseline, 3, 6 and 9-months post-therapy for each subject and may be used for carotenoid assay for biochemical verification of adherence.