To resume patients will intake Ragenium or placebo for 3 months (from 1 months before and until 2 months after non surgical periodontal therapy), each patient will intake one pill of Regenium Tablet in the morning (with breakfast) and one capsule of Regenium Capsule in the evening (with dinner). Patients assigned to the control group (n=30) will intake placebo tablets and capsules as prescribed in the test group. Compliance will be evaluated by pill counting at the end of the study.