Hypofractionated radiotherapy schedules are designed based on the premise of biological equivalent dose, modeled by the linear quadratic method. Possible schedules to achieve equivalent results can be given over 10 to 30 fractions. In 2002 and 2003, investigators from Toronto, Ontario and Cleveland, Ohio reported promising preliminary results based on 20 and 28 fractions per treatment course. This technique takes advantage of modern CT-based treatment planning systems and technologies to precisely target the prostate with maximal sparing of adjacent normal tissues.