This study will test an experimental drug called OROS® hydromorphone hydrochloride (HCl), a once daily opioid analgesic that can relieve pain. A large number of clinical studies have been conducted to test this drug. NMED-1077 is still being tested and is not approved by the Food and Drug Administration (FDA) for sale in the United States. OROS® hydromorphone HCl is currently approved in Europe to treat chronic pain.