1. Is CD163 pathophysiologically involved in adipose tissue inflammation in obesity? Adipose tissue (AT) is taken from various regions in lean to very obese subjects - from either subcutaneous fat biopsies (lean subjects), surgery (obese subjects - BMI> 30), and from bariatric surgery (gastric bypass) in the very obese subjects (BMI > 40) - both subcutaneous and visceral AT are investigated in parallel in the very obese individuals.