A recent study with another thiazolidinedione compound, troglitazone, has shown that there is no increase in cardiac mass or cardiac function impairment in patients with NIDDM . To the contrary, these patients were observed to have decreases in systemic vascular resistance, with enhanced cardiac output and stroke volume. Other studies examining thiazolidinediones have shown beneficial effects on Hemoglobin A1c with statistically significant decreases indicating beneficial effects on glucose homeostasis over periods of time.