This is a project looking to detect a 2-3% difference in BMD on DEXA scans as compared to the individuals' baseline DEXA. Based on previous data 11 and our own power analysis this will be achievable with a sample size of 30 patients in each arm (treatment vs. placebo) to ensure sufficient power (Kalloger Consulting, Inc). Our initial analysis will be performed after 30 patients have been randomized (15 FOSAVANCE, 15 placebo). Iif a clear advantage is demonstrated in the treatment group, the trial will be completed and treatment will be offered to all patients undergoing chemotherapy for gynecologic malignancies. If the difference is not yet statistically significant but a favorable trend is suggested we will enroll further patients in order to sufficiently power this series, again with the above specified goal of detecting a 2-3% difference in BMD, considered of clinical signficiance in the literature.