Objective: (i) To identify the differences between the "intervention" and "usual care" groups in Framingham risk scores, anthropometrical, biochemical parameters at baseline and at 24 months and compliance to prescribed regimens. Prevalence of maternal and paternal risk factors, DNA/mRNA profile and other risk factors may also be examined. (ii) To assess the relation between CIMT and psychosocial status with other conventional cardiovascular risk factors and serum levels of inflammatory markers in the "intervention" versus "usual care" groups over 2 years of follow up. (iii) Subjects that scored high on the emerging risk factors and IMT score will undergo CAC scanning. This will allow us to correlate the values of the CAC score in FDR's of patients with premature atherosclerosis to the IMT score and to the biochemical markers already captured in this study.