Not specifically the goal of the EASI Access trial, but potentially relevant for any future use of Hylenex, is that the ability to avoid IV access may be occasionally useful in the acute care setting. In patients who are very young, or cachectic, or simply need IV access for fluid replacement, EASI may be able to obviate the need for (possibly numerous) IV "sticks" and their attendant discomfort. The low, but nonzero, rate of IV access complications (e.g. thrombosis, phlebitis) in general may also be avoided by use of EASI access. The EASI Access investigation very clearly does not offer these potential advantages to the current trial's study subjects, but the hypothetical advantages to avoiding IV placement do provide further possible relevance to any positive findings in the EASI Access study.