In this research, we propose to develop methods and protocols for imaging-based, non-invasive early detection and diagnosis of colon cancer metastases. Colon cancer is the third most common cancer worldwide. While it is amenable to surgery if detected early, advanced carcinomas are usually lethal, with liver metastases being the most common cause of death. Early and accurate detection of these lesions is recognized as having the potential of improving survival rates and reducing treatment morbidity. Current diagnostic imaging offers improved discrimination and sensitivity that can be used for earlier detection of smaller lesions conducive to curative therapy.