The research programme will involve one country (Greece), and will include a total of 26 patients with type 1 or type 2 diabetes. The planned treatment period will be 32 weeks. Patients with clinically significant DME (i.e. BCVA < 0.4) refractory to at least two sessions of laser photocoagulation or who have leaking microaneurysms within the foveal avascular zone (FAZ) making laser photocoagulation unsafe for the central vision, will be included in the study. The study will be conducted in compliance with the protocol, ICH guidelines, Good Clinical Practice (GCP) and the applicable regulatory requirements