8. Patients must have organ and marrow function as defined below: Absolute neutrophil count (ANC) >/= 1.5 X 10^9/L; Hemoglobin >/= 9.5 g/dL; Platelets >/= 100 X 10^9/L; prothrombin time/international normalized ratio (PT/INR) and partial thromboplastin time (PTT) </= 1.5 X upper limit of normal (ULN); Total bilirubin </= 1.5 X ULN (isolated bilirubin >1.5 X ULN is acceptable if bilirubin is fractionated and direct bilirubin <35%); Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) </= 2.5 X ULN ^1; Albumin >/= 2.5 g/dL; Creatinine </=1.5 X ULN 2 OR Calculated creatinine clearance >/= 50 mL/min OR 24-hour urine creatinine clearance >/= 50 mL/min.