A sample size of up to 224 former ASPIRE participants will be selected to take part in Phase 1 of the study, and approximately 84 Phase 1 participants who then enroll in HOPE will be selected to take part in Phase 2. Participants will all be adult women from seven sites in three African countries: South Africa, Uganda and Malawi. It is anticipated that participants will be representative of the overall ASPIRE and HOPE trials by enrolling participants from each of the participating ASPIRE and HOPE countries.