You will take cobimetinib by mouth at the same time every day with or without food on a 3 weeks on, 1 week off schedule. This means you will take the study drug every day for 3 weeks in a row and then will not take cobimetinib for 1 week. If a dose of cobimetinib is missed or if you vomit a dose, do not take a "make-up" dose. Wait and take your next dose as scheduled.