In addition to that, a single study by our group has compared single agent doxorubicin versus single agent docetaxel as neoadjuvant chemotherapy for locally advanced breast cancer. In this study, both drugs were similar in luminal and her2 subtypes, but docetaxel was significantly superior to doxorubicin in patients with basal-like tumors (good pathological response rate of 56% vs 0%, p=0.034). Besides, triple negative status was the only significant predictor of resistance to doxorubicin in multivariate analysis. Residual cancer burden after neoadjuvant chemotherapy in triple negative tumors was also significantly higher with doxorubicin than with docetaxel, thus indicating that this subtype is more resistant to doxorubicin than to docetaxel. This study firmly suggest that docetaxel should be the backbone of combination regimens for basal-like tumors and questions the role of doxorubicin in these tumors.