There are also data that show that women using insecticide treated bednets (ITNs) during pregnancy are also less likely to suffer the adverse outcomes of malaria during pregnancy. The World Health Organization (WHO) currently recommends that all pregnant women in malaria endemic areas sleep under an ITN and receive at least 2 doses of IPT with an efficacious antimalarial in the 2nd and 3rd trimester. The combined efficacy of ITNs and IPT remains unclear. It is important to understand if a short-acting antimalarial such as CD will function as well as a long-acting drug such as SP in preventing malaria during pregnancy among women who are also sleeping under an ITN. Therefore, the secondary aim is to estimate the proportion of pregnant women sleeping under ITNs who become re-infected with malaria before delivery following administration of a single dose of chlorproguanil-dapsone for P. falciparum parasitemia.