Through Objective #2, we will determine the effectiveness of walnut OIT in the induction of clinical desensitization to walnut. Prior studies have demonstrated the ability to change the threshold of allergen needed to induce anaphylaxis to specific foods, including egg and peanut. We anticipate that walnut OIT will provide protection from anaphylaxis (i.e., clinical desensitization) to walnut in subjects that have proven clinical reactivity to walnut protein. If walnut OIT proves to be effective in inducing desensitization, the treatment would provide a useful and feasible option for preventing life-threatening reactions that would be specific to walnut allergic subjects. Additionally, we may be able to induce clinical tolerance in a subset of walnut allergic subjects using this OIT approach.