2. Impact The direct beneficiaries of the study are represented by physicians Department of Anesthesia and Intensive Care County Hospital Emergency "Pius Brinzeu" Timisoara that will have a very useful tool in clinical practice and research with direct impact on patient outcomes (approx. 3000 patients / year). Also, the entire local medical and scientific community: doctors, medical researchers and teachers. Through interdisciplinary nature of the specialty of anesthesia and intensive care, direct beneficiaries of research results in this area are represented by physicians from a wide range of medical specialties: surgery, neurosurgery, cardiology, infectious diseases, orthopedics and traumatology, clinical biology, genetics and so on. They will retrieve new information brought by research, will implement and apply it themselves on a new target groups of patients, thus expanding the distribution area of potential beneficiaries. Lastly, the economic environment through technology transfer from research results to other clinical and experimental centers.