The Investigators plan to enroll 300 patients undergoing surgical procedures requiring general anesthesia with mechanical ventilation will be recruited and consent will be obtained. The subjects will be randomized preoperatively to receive in the OR following the procedure and prior to extubation either sugammadex (Group 1, n=150 patients) or placebo (Group 2, n=150 patients). In all patients, intraoperative surgical and anesthetic management will follow the usual clinical routine at the two enrolling institutions. Once surgery is finished, emergence from anesthesia will occur as per usual clinical routine until the clinician determines that the patient is ready for tracheal extubation. Once the decision to extubate the trachea is made, the patient will receive intravenously either sugammadex 2 mg/kg or placebo in a blinded manner. The patient's trachea will be then extubated, and postoperative anesthetic care will proceed as per usual routine. Patients will then be transferred to the PACU for postoperative care and recovery. (This methodology will ensure that all 300 patients will receive at least the current standard of clinical care. Of the 300 patients, 50% of them (n=150 patients) may benefit from the administration of sugammadex, which may decrease the incidence of residual neuromuscular block.)