Methods: There will be a total of 3 patients undergoing this experimental surgical procedure once meeting all entry criteria and subsequent to obtaining informed consent These patients will be recruited from the Baystate ambulatory surgery clinics.. Preoperative laboratory testing, such as blood work (liver function tests, amylase and lipase, a white blood cell count, and a pregnancy test), as well as ultrasound of the liver to document gallbladder disease will be performed as is the standard for patients undergoing surgical removal of the gallbladder. In this procedure, after the induction of general anesthesia and creation of a culdotomy, a sterile endoscope would be inserted into the vagina and then into the abdomen. Following the insertion of the endoscope, a retraction stitch will be passed through the abdominal wall and into the gallbladder to retract the fundus of the gallbladder in a cephalad direction. A 5-mm trocar will be placed in the umbilicus and will serve two functions: one, to allow for a laparoscope in case the view becomes compromised or substandard; and two, to allow a clip applier to be placed in the abdomen for clipping the cystic artery and cystic duct. Dissection of the gallbladder can commence using endoscopic tools and removal of the specimen will be directly through the culdotomy and out through the vagina. Utilizing this technique, as many as three surgical incisions can be avoided.