To sum up, CT+RT has the advantages of potential radiosensitization by chemotherapy induced cell cycle redistribution, overcoming radio-resistance within the field of RT, targeting different subpopulation of cells leading to more kill, reduction or delay in distant metastases. Its disadvantages are increased expense, enhanced toxicity and need of good interdisciplinary integration. What needs to be appreciated is the fact that CT+RT has never been evaluated against the standard treatment of TL + PORT. Although the quality of life has been reported to be better after laryngeal preservation, speech rehabilitation has improved steadily over past decade. Time seems to be ripe now to compare LP with CT+RT with TL+PORT and speech rehabilitation with locoregional control and quality of life as endpoint.