This study will be conducted in Northern Ethiopian prisons. Ethiopia had an officially registered prison population of 112,361 (136/100,000 persons) in 2010 [22], which is higher than the imprisonment rates observed in some sub-Saharan African countries such as in Kenya (121/100,000 persons), and Malawi (76/100,000 persons). The fact that prisons are overcrowded and inadequately ventilated means that Ethiopian prisons are ideal for the transmission of Mycobacterium tuberculosis [23] and urge appropriate interventions. This interventional study will be conducted in 16 main prisons (8 matched pairs) located in the Amhara and Tigray regions including Mekelle vs. Shire, Adawa vs. Tembien, Humera vs. Adigrat, Mychew vs. Alamata, Wukro vs Axum, Dessie vs. Woldya, Fenoteselam vs. Debremarkos, and Debretabor vs. Bahir Dar for a one year period from March 2016 to March 2017. This interventional study focuses only in prisons of the Northern Ethiopia considering feasibility. All the prisoners in the 16 selected prisons are study populations.