Based on these data, investigating the effectiveness of the intervention in RA patients is highly warranted. The study described in this protocol is part of a larger project in which the investigators ultimately strive to translate the intervention to clinical practice for RA patients. However, there are important issues that need to be addressed first. For example, feasibility and safety would be substantially improved if patients would only have to learn or practice one of the three elements of the intervention. The meditation element is not likely to be involved. It was a very minor part of the training program and was not practiced during the endotoxemia experiments. Also, there is no objective manner to measure this element and there is no hypothesis for a possible mechanism. Concerning the second element, exposure to cold, it would especially be of value to determine whether this element has additional value, because it is very demanding and might not be suitable for RA patients at all. The investigators anticipate that the third element, breathing techniques, is the major contributor to the anti-inflammatory effects of the intervention previously observed for reasons outlined below.