Indapamide is a diuretic with special characteristics, which was shown in experimental studies to provide cardio- and renal- protection in hypertensive patients. In the same time it has similar antihypertensive effects with amlodipine and hydrochlorothiazide. Intrinsic mechanisms are probably related to the antioxidant properties, and also to the action on the calcium channels. Moreover, when compared with hydrochlorothiazide, indapamide has no adverse effects on lipid metabolism and seems to have no negative impact on the renal function. However, a recent study in patients with hypertension and diabetes suggested no superiority of indapamide over hydrochorothiazide on different metabolic parameters. Therefore, new research looking in more detail to the comparison between the two diuretics is mandatory.