Methods: There will be three phases and the study site in the medical center in northern Taiwan. The first phase is information needs assessment. Researchers will hold the meeting of focus group discussion. The subjects will be the nursing manager, head nurse, clinical nurses who are similar to nursing-related patient safety and quality indicators. The self-conducted semi-structure discussion form will be used to collect the data during the meeting of focus group discussion. The questionnaire will be used to collect the perception, attitude, behavior, satisfaction, time-consuming and the accuracy of nursing-related patient safety and quality indicators data from nurses. The second phase will establish the monitoring information system of nursing-related patient safety and quality indicators and clinical implementation. The third phase will evaluate the effectiveness of the monitoring information system of nursing-related patient safety and quality indicators. The questionnaire will be used to collect the satisfaction, time-consuming and the accuracy of nursing-related patient safety and quality indicators from nurses during the evaluation phase.