Gabapentin Gabapentin is an anti-epileptic agent originally developed to treat spasticity (1), and eventually was found to be effective against chronic neuropathic pain (1,2). Gabapentin is available as an oral preparation and is primarily absorbed in the small intestine (1). Gabapentin is not metabolized in humans and is eliminated unchanged via the kidneys. It has no known drug-drug interactions, but it is reported that antacids can reduce the bioavailability of Gabapentin by about 20%, and Cimetidine can decrease the clearance of Gabapentin from the body by about 12% (1,2). Side effects of Gabapentin tend to be mild with somnolence (20%), dizziness (18%), ataxia (13%), and fatigue (11%) being the most common (1). The exact mechanism of Gabapentin in pain management is unknown, but it has demonstrated inhibition of mechanical hyperalgesia, and mechanical/thermal allodynia in those with neuropathic pain (1).