After documentation of the H. pylori infection, the primary physician will introduce the patient to the research fellow who will give to the patients a clear explanation of the purpose of the study, risks, and benefits. Those who agree to participate and sign the informed consent will be enrolled in our study. All patients will take the treatment for ten days. The patients will be assessed for side effects on days 5 and 10 of the treatment regimen. The eradication rate will be assessed periodically (every 10 patients for the first 50 patients) for efficacy and the study will be stopped if the target rates are not met. The Pylera tablets will be provided free to patients. However, the amoxicillin and esomeprazole are not provided freely.