- Subjects with ≥3 unfavorable prognostic factors defined by Heng et al., (KPS <80 %, Hgb < LLN, ANC>ULN, platelet count>ULN, corrected serum calcium >ULN, and time from original diagnosis to initiate targeted therapy <1year), which has median survival 7.8 months and 2-yr survival of 7%.