4.4 Endpoints to be recorded: see Chapter 7 for details A.Clinical endpoints. Rate of all TE or major bleeding. The major efficacy endpoint is symptomatic diagnosed TE events or death from TE and the major safety endpoint, is major bleeding, including death from major bleeding (Palareti 1996; Abdelhafiz and Wheeldon 2004). TE and major bleeding as a combined endpoint. Death and causes of death from natural causes. All bleeding (major and any other reported bleeding) B. Convenience/surrogate endpoints, eg. time within target range, number of tests within target range, number of tests during study period, number of tests needed to achieve stable anticoagulation.