Coffee is a popular beverage globally and elevates blood pressure variably among individuals. Customers in the United States comprise more than half of the population over the age of 18 years, consume an average of 1 cup (typical size: 270 ml) of coffee three times per day and spend an estimated $ 40 billion on the purchase of it each year. A major active constituent in coffee is caffeine, which is the most widely used pharmacological substance in the world.