Epilepsy In The Elderly The incidence of epilepsy increases as age advances beyond 50. Indeed there is a two- to three-fold increase above the age of 75 years compared with any other age group (Ramsay et al. 2004). This special population is at increased risk for development of adverse events related to AED treatment as they are likely to have multiple medical conditions, take numerous concomitant medications, have different metabolic characteristics, and are more likely to suffer from neurologic conditions such as stroke and dementia. The elderly are more susceptible to cognitive impairment by AEDs. However, little is known of factors affecting health-related quality of life in senior adults with epilepsy (Martin et al., 2003)6. All older AEDs have clear pharmacokinetic disadvantages as they are liver metabolized with many known drug interactions.