- At NCI and Univ of Oklahoma, post-pubertal pediatric male patients (<18 years) will be randomized to receive a 3 month (11.25 mg) injection and adult male patients will be randomized to receive 4-month preparation of Lupron (30 mg) or placebo two weeks before the preparative regimen for first BMT. Women and all individuals undergoing 2nd BMT will receive Lupron at these doses per age and be evaluated in the treated cohort. At Children s National Medical Center, the patients will not receive Lupron outside of the context of clinical care, and will receive myeloablative HSCT as per standard of care with FLT imaging for engraftment as the only primary endpoint.