Analyses are by intention-to-treat and then per protocol principles. The primary outcome between groups over 30 days is compared using a time-to-event type analysis with a log rank test. An adjusted analysis or Cox regression model will be used in the presence of significant difference in the baseline covariates. Initial rate of hemostasis and recurrent bleeding within 30 days are independently reported and compared using a chi-square test. Categorical data in secondary outcome measures are compared between groups again using chi-square test. Parametric and non-parametric data are compared using student's t test and Mann-Whitney U test respectively.