16. Use of prescription or non-prescription drugs, vitamins, herbal, and dietary supplements, within 14 days or 5 half-lives (whichever is longer) prior to the first dose of study drug, and willingness to refrain from taking any such medication until after the last protocol specified blood sample. The use of acetaminophen, not to exceed a total daily dose of 1 g, is permitted up to 24 hours prior to admission to the investigational site and then prohibited until after the last protocol specified blood sample. The use of stable hormone replacement medication by women, topical steroids, and stable thyroid medication is permitted. Medication regimens are considered stable if the dose and schedule of administration has not changed within the prior 3 months and is not expected to change for the duration of the study;