5-fluorouracil (5FU) is a chemotherapeutic agent that has been used systemically for various malignancies, but it has also been used topically or intralesionally for a variety of dermatological conditions. But reports of its use in invasive cutaneous SCC, other than in keratoacanthomas, are very limited. The investigators are aware of 3 such reports in the literature. In the largest study to date, 6 weekly intralesional injections of 5FU-epinephrine gel were performed on 23 patients with cutaneous SCC on various body sites, 22 (96%) of whom demonstrated histologically confirmed tumor clearance. This study, however, used a proprietary gel formulation which is not widely available. There are two other case reports of successful treatment of SCC with 6-8 intralesional injections of 5FU at weekly intervals. The three published studies injected 0.6ml to 2.4ml of 5FU, per each weekly session, at concentrations of 30mg/ml to 50mg/ml.