8.1) Female patients ≥ 50 years of age at the day of inclusion, who have been postmenopausal for at least 1 year 8.2) Female patients < 50 years of age at the day of inclusion, who have been postmenopausal for at least 1 year and serum follicle stimulating hormone levels > 40 milli International unit / mL as well as serum estrogen levels < 30 pg/ml or a negative estrogen test.