Both genetic and environmental factors have been linked to the risk of aggressive disease. The ethnic origin is likely to play a role, since the proportion of cases diagnosed at the metastatic stage is reported to be higher for African-American patients (35%) than for European-American patients (22%), with a 2.4-fold higher mortality rate in AA men than in EA men (2).Together with genetic factors, environmental factors also seem to play a key role in PCa progression. Some environmental factors such as obesity have been associated with aggressive PCa (6). However, much remains to search about the role of genetic and environmental factors and their interplay in PCa aggressiveness. White adipose tissue (WAT) and lipids are potentially involved in the development and/or progression of PCa at many levels.