Data from these patients will be used for analysis, to build predictive models. A copy of the PDMS database, after removal of all data that refer to the identity of the patients, will be used for data analysis. Data mining models, such as simple logistic regression models, but also more advanced machine learning techniques (models automatically learned by a computer algorithm, such as Decision Tree models [9], Bayesian Networks, Gaussian Processes, Support Vector Machines, …), will assess the independent predictive power of the FORE-SIGHT™ signal over the routinely monitored data.