7. 7) Adequate organ function defined by the following parameters • Serum creatinine </= 1.5 mg/dl. Creatinine clearance (CrCl) >/= 50 mL/min calculated by the Cockcroft-Gault method as follows: male creatinine clearance = (140 - age in years) x (weight in kg) / (serum Cr x 72); Female CrCl = (140 - age in years) x (weight in kg) x 0.85 / (serum Cr x 72). • ANC>/= 1500/mm^3, platelets >/= 100,000/mm^3 • Hemoglobin >/=9.0 g/dL • SGOT (AST) and SGPT (ALT)< 3.0 x upper limit of normal • Alkaline phosphatase (Alp) </= 2.5 x ULN • Total bilirubin </=1.5 x ULN