Descriptive statistics will be used to synthesize the data recorded in the initial and final evaluations. The statistical analysis of the clinical parameters will be performed to compare the initial values with the values after the experimental periods (6 and 12 months). The analysis of the data will be done by paired t test, if obeyed the distribution normal or Wilcoxon if it obeys the non-normal distribution. The level of significance adopted will be 5% (p <0.05).