Every time a patient has a contact (eg INR measurement or dosing instructions), the dosing staff or study nurse will ask questions by exactly following the case review form (CRF, 14.2). If the questions are answered with a "yes", the study nurse will without delay contact that particular patient for more detailed information (i.e. HCRU form see: Event report form / Health Care resource utilization (HCRU)), and, as appropriate, will also collect necessary case record documents for the IAC.