Immunoglobulin light chains are able to interact with B lymphocyte membranes leading to the activation of transmembrane signaling . The ensuing impairment of neutrophil function can contribute to the chronic inflammation state of uremic patients and to the increased risk of bacterial infection. Desjardins et al. demonstrated an association between free light chain levels and vascular calcification progression in chronic kidney disease patients. Nonetheless, serum free light chains in patients with chronic kidney disease are associated with the risk of end stage renal disease and death.