- Adequate Renal Function Defined As: Creatinine clearance or radioisotope GFR > 70 mL/min/1.73 m2 or a serum creatinine based on age/gender as follows: 2 to < 6 years (male=0.8, female=0.8), 6 to <10 years (male=1, female=1), 10 to < 13 years (male=1.2, female=1.2), 13 to < 16 years (male=1.5, female=1.4), and ≥ 16 years (male=1.7, female=1.4)