Participation in this study is expected to add no additional risk to the patient. The only risk expected to occur with any frequency is irritation of the skin while applying the TOT bag. This issue is anticipated in the protocol, which specifies appropriate treatment modifications and discontinuation of Topical Oxygen, if the problem does not improve. This problem, if it occurs, is expected to be self-limited and of minor significance. Oxygen although not combustible itself, supports combustion of other flammable materials. The use of oxygen in this protocol is essentially equivalent to that supplied by nasal cannula to patients in hospital or at home. To minimize the risk of fire the investigators will strictly enforce a no smoking and no open flame policy in any room in which Topical Oxygen is utilized. Treatment facilities will comply with local fire ordinances and study personnel will be familiar with fire safety protocols of each facility.