Blood samples to measure GM-CSF levels will be taken on the day of vaccination, every day for 4 days, and then on day 7 after vaccination. Blood samples to evaluate the safety of the vaccinations will be taken about once a week for one month following each vaccination. During studies of the breast vaccine and similar vaccines in renal cell cancer, prostate cancer, pancreatic cancer, and non-small cell lung cancer, local symptoms of swelling and redness developed at the vaccine site between 2 and 7 days after vaccination. In this study, if the subject's vaccination site shows swelling over 1 cm in diameter, a skin biopsy will be taken. The skin biopsy will be evaluated to determine to what types of cells are important to the immune response. Based on our previous preclinical and clinical data, the biopsy will be taken on day 3, and possibly on day 7, after the first and third vaccinations. Other tests and evaluations include history and physical examination, vital signs, CT of the chest, abdomen, and pelvis, nuclear medicine bone scan, pre-vaccination biopsy, blood for immune monitoring, and a skin test for delayed-type hypersensitivity (DTH) that is like a PPD test and involves injecting pieces of a protein antigen (HER-2/neu) that is delivered by the breast cancer vaccine. The purpose of the DTH test is to evaluate whether the research subject has developed a systemic immune response to the breast cancer vaccine. Tumor core needle biopsies will be obtained at baseline, and on days 0 and +14 of vaccine cycle 1 only.