Coronary computed tomographic angiography (CCTA) of 64-detector rows or greater hold promise as a non-invasive modality, and has often displayed high diagnostic performance for the evaluation of CAD as compared with invasive coronary angiography. CCTA is capable of evaluating specific features of atherosclerotic plaque as well as coronary arterial wall in a similar fashion to IVUS. Consequently, APCs can be readily visualized by CCTA in culprit lesions post ACS and have demonstrated high agreement with invasive methods. Though to date, the utility of APCs by CCTA for prognostication of future risk of ACS remains unexplored either at a per-patient or per-lesion basis. Further still, no adequately sized study has examined the gender-specific disparity in APCs among individuals prior to the occurrence of an ACS.