- Dose normalized AUC [AUC0-inf,norm], dose normalized Cmax [Cmax,norm], AUC0- tz, time of occurrence of Cmax [tmax], apparent terminal half life [t½], mean residence time [MRT], apparent (oral) total plasma clearance [CLtot/f], apparent volume of distribution during the terminal disposition phase [Vz/f], AUCextrap%, apparent terminal disposition rate constant [λz], weight corrected AUC0-inf, weight corrected AUC0-tz, weight corrected Cmax, weight corrected CLtot/f, cumulative amount of excreted Neramexane into urine [Ae0-tz], fraction of orally administrated drug excreted into urine [fe/f], renal clearance [CLR] and apparent non-renal clearance [CLNR/f]