- If at least 20% of the Japanese or of the Caucasian subjects have an area under the plasma concentration curve extrapolation [AUCextrap%] >20% relative to AUC0-inf for one of the dose groups area under the plasma concentration curve from zero to the last measurable concentration [AUC0- tz] becomes primary parameter for Japanese and Caucasian subjects for all of the dose groups. In this case AUC0-tau will become a secondary parameter