Analysis The analysis of the results of this study will be descriptive. A screening log will be kept and the number of patients screened for this study will be recorded. Patients who are eligible to participate and who give informed consent will be described according to the following parameters: age, gender, underlying indication for transplant, type of transplant, number of red cell transfusions received prior to transplant, number of red cell transfusions from the start of conditioning until study enrollment and ECOG performance status at time of study entry. The feasibility of the intervention will be recorded by describing the proportion of patients who complete the planned series of 12 phlebotomies. In order to consider the patients who are unable to complete all 12 phlebotomies, the total number of actual phlebotomies conducted in the trial will also be recorded and expressed as a proportion of the total number of planned phlebotomies. The number of phlebotomies per patient per time period will also be reported. The efficacy of the intervention will be recorded by describing the changes in serum ferritin and transferrin saturation, liver enzymes and liver function, endocrine parameters and liver and cardiac iron stores as determined by liver MRI. Cardiac function will also be determined at study entry and 6 and 12 months following the start of the series of 12 planned phlebotomies. The safety of the intervention will be recorded by evaluating the number of patients who had adverse and/or serious adverse events.