- Positive for hepatitis B surface antigen [HBsAg+], OR negative for hepatitis B surface antigen [HBsAg-], but positive for hepatitis B core antibody (HBcAb+) and/or positive for hepatitis B surface antibody (HBsAb+) with positive Hepatitis B virus (HBV)-DNA (≥2.1 Log copy/mL by Polymerase Chain Reaction [PCR] method) detected in the serum