Docetaxel and carboplatin was evaluated in another phase II study in 40 patients with previously untreated MBC. Patients received docetaxel (75 mg/m2) and carboplatin (AUC 5) on day 1 every 3 weeks for up to 6 cycles. An ORR of 59% (CR 15.4%, PR 43.6%) was observed among the 39 patients evaluable for response. Grade 3/4 toxicities included neutropenia (n=28), febrile neutropenia (n=4), and thrombocytopenia (n=4). The authors concluded docetaxel and carboplatin were efficacious as first-line treatment for metastatic breast cancer, with an acceptable toxicity profile.