12. ADDITIONAL INCLUSION CRITERIA FOR BRAF MUTATION (COHORT 1): Serum albumin >/=2.5 g/L, Total bilirubin </= 1.5 × ULN, AST and ALT </= 2.0 × ULN, Alkaline phosphatase (ALP) </= 2.5 × ULN or, for patients with documented liver or bone metastases, ALP </= 5 × ULN, Serum creatinine </= 1.5 × ULN or creatinine clearance (CrCl) >/= 40 mL/min on the basis of measured CrCl from a 24-hour urine collection or Cockcroft-Gault glomerular filtration rate estimation: CrCl = ((140 － age) / (serum creatinine in mg/dL)) × (weight in kg) (× 0.85 if female)/ 72). Patients with BRAF mutation may be screened for eligibility in cohorts 2, 3, or 4 (in this order of preference) if they do not meet the entry criteria for cohort 1.