- to evaluate the risk-benefit, he impact on treatment on patient quality of life, the management cost of patients treated with the validated and future treatments of metastatic melanoma. If possible, cost-effectiveness ratios wil be calculated either in all treated patients or in selected populations of patients (based on clinical or biological criteria, like biomarkers), in order to identify the populations in which these new therapeutics will be the more cost-effective. The project also aims to define predictive biomarkers of response and toxicity including pharmacogenetics and tumor genetics alterations, tumor microenvironment characteristics, individual immunological profile.