To fully describe the phenotype of interstitial cystitis (IC)/painful bladder syndrome (PBS)/chronic pelvic pain syndrome (CPPS), in adults and children, and to correlate the phenotypic information to the genotypic findings utilizing linkage analysis, whole exome sequencing and candidate gene studies. Both individuals and families with IC/PBS/CPPS symptoms will be recruited to give a DNA (from saliva) and urine samples and answer 2 questionnaires. Travel to Boston NOT necessary.