Adequate bone marrow reserve: absolute neutrophil count (ANC) should be ≥ 1500 cells/mm3, platelets should be ≥100.000 cells/mm3 Creatinine clearance ≥ 45 mL/min Total bilirubin < 1.5 x ULN AST (SGOT) < 3 x ULN (< 5.0 x ULN if hepatic metastases) ALT (SGPT) < 3 x ULN (< 5.0 x ULN if hepatic metastases)