Gastroesophageal reflux disease (GERD) is a clinical condition characterized by troublesome symptoms and medical complications as a result of reflux of gastric contents into the esophagus. GERD is diagnosed in 4% of primary care outpatient visits and the disease prevalence in Latin-America reaches 12-31%. Nocturnal symptoms have been found in 74% of patients with GERD and are a cause of significant quality of life impairment, when compared with general population and patients with GERD and daytime-only symptoms. Sleep interference secondary to nocturnal retrosternal burning has been associated to lower work productivity, even in patients being treated with proton pump inhibitors (PPI). Due to several physiological factors such as lack of conscious perception of symptoms, reduced salivation and a lower frequency of nocturnal swallowing, a significantly longer acid exposure overnight has been associated to the emergence of complications like esophagitis, more extra-esophageal symptoms and other illnesses such as asthma.