The pharmacy will store Ibuprofen and on the day of surgery will provide the covered bag of ibuprofen 800mg versus saline solution labeled with the patient's name .Group assignment (A or B) will be known to the pharmacy only. IV will be started and first dose of medication will be given over 5-30 minutes preoperatively. In the subgroup of patients, where surgery start time is delayed by one hour or more, PPT will be repeated before the start of the surgery.