Because the study will provide examination results to participants and their physicians, there is expected to be a significant amount of clinical intervention in individuals, depending on the severity of the disease, the acceptance of the test results by the medical community, and the aggressiveness of the individual treating physicians. The study will collect information on the nature and magnitude of such interventions to control for them in analyses. Approximately 15 percent of the highest risk participants will be selected for this comprehensive examination and follow-up. Assuming that a large proportion of these high risk participants will be referred for an intervention that substantially modifies their risk, the effective sample size after accounting for the intervention effect is assumed to be 10 percent, rather than 15 percent. All participants will be followed for identification and characterization of cardiovascular disease events, including acute myocardial infarction and other forms of coronary heart disease, stroke, and congestive heart failure; mortality; and for any cardiovascular disease interventions received.