Role of platinum salts in TN breast cancer The role of platinum salts in TNBC is currently a matter of investigation. Basal-like breast cancers (BLBC) are highly aneuploid, associated with BRCA1 germline mutations, and have loss of TP53, RB1 and Chromosome 5q. None of these characteristics are observed in Claudin-low tumors suggesting a different etiology, and possibly, a different response to DNA damaging agents. Phase II studies have suggested that platinum salts have a significant activity en TNBC, particularly in BRCA-1 mutation carriers. Unfortunately, we cannot distinguish TNBC from Claudin-low with conventional IHC techniques.