Flutamide is an acetanilid, nonsteroidal, orally active anti-androgen that exerts its anti-androgenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Flutamide has been demonstrated to interfere with testosterone at the cellular level. This can complement medical castration achieved with LHRH agonists that suppress testicular androgen production by inhibiting luteinizing hormone secretion (Brogden, 1989).