Although not expected based on the literature (i.e. in the absence of bolus dosing), subjects will be monitored for side effects as described previously following NAC administration to healthy volunteers: peripheral effects (swelling, sweating, erythema, pruritis, conjunctivitis), altered sensations (lightheadedness, drowsiness, dysphoria, metallic taste), gastrointestinal disturbances (nausea, dyspepsia, flatulence, diarrhea), and hypotension. Side effects will be assessed and recorded by CRC nursing staff as well as by the investigators. Our intent is to avoid side effects and, if they should occur, manage them with reduced dosing or, if necessary, diphenhydramine administration, as directed by the study physician(s). Subjects with a history of asthma will be excluded, as they have been reported to experience more severe anaphylactoid reactions to NAC.