Most neoadjuvant regimens that have been used in the past have only included induction with 3-4 courses of an anthracycline based regimen without a Taxane, followed by surgery and further chemotherapy subsequently. However, the incorporation of docetaxel after an anthracycline-based regimen (Aberdeen and NSABP-B27 protocols) [4, 9]led to better clinical response, subsequently to better breast conservation and more important, an increase in the pathological complete response rate. In the NSABP-B-27 study, 2,411 patients with operable primary breast cancer were randomly assigned to one of three treatment arms: a) four cycles of preoperative AC followed by surgery. b) four cycles of preoperative AC followed by four cycles of preoperative docetaxel (100 mg/m2 IV every 3 weeks), or c) four cycles of AC followed by surgery and subsequently four cycles of postoperative docetaxel. Compared to preoperative AC alone, preoperative AC followed by preoperative docetaxel increased the clinical complete response rate (40.1% v 63.6%; P < .001), the overall clinical response rate (85.5% v 90.7%; P < .001), the pathologic complete response rate (13.7% v 26.1%; P < .001), and the proportion of patients with negative nodes (50.8% v 58.2%; P < .001).