For Arms 1-3. Screening: the collecting of complaints, anamnesis, physical examination, X-ray of chest,spirometry with bronchodilator, ORL examination, ACT-C, ACQ5, CAT, CCQ-tests, test the six-minute walk, clinical analysis of blood leukocyte count, allergiamelone (skin prick tests and/or determination of specific IgE), cytology tests of nasal secret.