We anticipate low incidence of these particular abnormalities. In a prior study in which the same dose of vitamin D3 (100,000 IU) was administered every 60 days for 6 months, Guillemant et al. reported no instances of hypercalcemia in French adolescent males, ages 13-16, with seasonal vitamin D deficiency (Guillemant 2000). In addition, in an on-going study conducted by Dr. Shane (Prevention of Osteoporosis After Cardiac Transplantation, ROI AR 46124-04), among the 74 subjects receiving the metabolically active form of Vitamin D, calcitriol (0.25 ug BID), there were only 4 episodes of urinary calcium excretion >400 mg/g creatinine. Besides being on calcitriol, these subjects were receiving corticosteroids, which also increase urinary calcium excretion. Corticosteroids are not a permitted co-administered medication in the present study.