Each subject will undergo a total of 9 visits. Subjects' eligibility will be assessed at Screening, which can occur up to 28 days prior to dosing. Following a repeat eligibility check at Day 0, eligible subjects will be randomized and dosed with the randomized treatment (BPL HRIG /vaccine or Comparator HRIG/vaccine on Day 0. Further administration of assessments will be conducted on Days 3, 5, 7, 14, 28, 49 and the end of study assessment on Day 140.