An infection is considered HAI if all elements of a Centers for Disease Control and Prevention/National Healthcare Safety Network (CDC/NHSN) site - specific infection criterion are all present on or after the third calendar day of admission to the facility. Any infection before the third calendar day of admission will be considered as infection present on admission, except in case of CLABSI; which can occur even on day two of central venous catheter insertion. CLABSI, primary and secondary bloodstream infections sepsis and severe sepsis will be the main focus for infection documentation. All the patients eligible as per the enrolment criteria for CLABSI surveillance will be monitored from admission to the ICU. Ventilator associated pneumonia and catheter associated urinary tract infection will also be monitored using established guidelines in order to have a more specific rate of CLABSI and related complications. Appropriate clinical data, imaging, specimens for biochemical and microscopic examination and culture will be documented at specific time points defined as per specific HAI check list . Device associated complications include central venous catheter occlusion, haemorrhage and deep venous thrombosis. All these safety margin indicators will be defined as per specific guideline definitions.