The use of placebo is justified in this investigation as our current standard of care does not include any treatment for prevention of bone loss during chemotherapy. A recent survey of our patients in active treatment at the BCCA revealed that only 1 of over 40 patients with gynecologic malignancies undergoing chemotherapy was taking any medical therapy for bone loss (Personal communication, J McAlpine J Pike). In order to provide some support for bone mineral density (BMD), all patients enrolled in this study (treatment and control arms) will receive Calcium (1000mg) and Vitamin D supplementation (1000 mg) during the 12 month study period. FOSAVANCE was chosen as the bisphophonate in this investigation as it is the most popular bisphosphonate in Canada and routinely prescribed to thousands of men and women. It has undergone rigorous scrutiny at the federal and provincial levels. Recently, Vitamin D has received considerable press for its "anti-cancer" activity in addition to its known contribution to bone growth and remodeling.