In BC, the BC Oral Biopsy Service (OBS) and the Pathology Department at Vancouver General Hospital (VGH) receive biopsy and surgical specimens from the dental and medical communities, respectively. These centralized biopsy services offer a very rare opportunity to establish a population-based cohort of OPLs. The pathologists team will identify eligible patients through the pathology sign-out process and call the submitting physicians to notify the potential referral pipeline as an alternative management for these patients. Currently, a referral pipeline for severe dysplasia or more advanced oral malignancy using this model exists and has been established to refer surgical patients for the TFRI-funded COOLS trial (by Drs. Durham and Poh; H09-03090). This same system/pipeline will be used to identify eligible patients diagnosed with mild and/or moderate dysplasias identified from both medical and dental communities.