If a participant reports that she has not used the cream or has returned the syringes unused, she will be removed from the study for lack of compliance. Study participants will also be removed from the study if they develop or have a new diagnosis of any conditions that are listed in the exclusion criteria. Finally, they will be removed if any allergic reactions/adverse events occur from the use of Estrace or placebo. There will be no replacement procedure for study participants if they are withdrawn. No actions will follow or are warranted after study participant removal.