Safety Monitoring: A study nurse and/or the research program coordinator will round on subjects daily to track their clinical progress and the occurrence of any serious adverse events (SAE) or adverse events (AE). All SAEs will be reported to the IRB, DSMB, and FDA within 24 hours. All other adverse events will be reported to the PI, IRB, and FDA on a weekly basis. Specific events potentially related to the study drug, based on prior knowledge of the pharmacology of progesterone, combination agents that include progesterone, and the Intralipid carrier, will be closely monitored by the study team. These events include: a) phlebitis at the injection site; b) sedation unexplained by administration of other CNS medications; c) an increase in liver enzymes; d) unexplained hyperglycemia; e) hypotension or hypertension not known to be associated with increased intracranial pressure; f) unexplained fever; g) thromboembolic disease; and h) sepsis. Baseline metabolic parameters will be determined from the initial blood draw prior to study drug administration. Blood sampling will be performed at least once per day during drug administration for monitoring. In addition, hourly vital sign measurements and other parameters will be obtained from ICU charting forms. Patients will be examined daily by team members for any signs of adverse reactions. Team members will also review charting, laboratory reports and treating physician notes daily. In addition, all trauma deaths are reviewed by an interdisciplinary Trauma Outcome Review Committee (TORC) to determine if the death was non-preventable, potentially preventable, or preventable. A member of our study team will attend all of these meetings. If/when TORC reviews a death involving a participant in the study, their findings will be shared with the DSMB as well as the P.I. and co-P.I. The DSMB will closely monitor the incidence of death and other serious adverse events such as sepsis or thromboembolic disease. If they have concerns about the incidence of any of these events as linked to the study drug, they will immediately report these concerns to the National Institute for Neurological Disorders and Stroke (NINDS), as well as to the Emory IRB. Furthermore, all occurrences of death (regardless of cause) and unexpected serious adverse events will be reported to the Food and Drug Administration (FDA).