Statistical analysis and sample size calculation Data distribution will be assessed by the Kolgomorov-Smirnov test. Comparison between groups will be performed by Anova or Kruskall-Wallis test as appropriate. Post-hoc comparison will be performed with the Bonferroni correction. Comparison between categorical variable will be done using the Fischer exact test. Student T test for dependent variables will be used to compare changes in LV volumes in each group over time and interaction assessed by Anova. Pre-specified sub-group analysis according to main clinical and angiographic data will be also performed, in order to identify subgroups of patients who may have a particular benefit from treatments.