This study is to observe the effect of application of topically administered oxygen on healing rate, cost of care and rate of amputations in diabetic patients with chronic wounds(s) . The proposed study is a pragmatic (comparative effectiveness research, CER) study, in which the effectiveness of topical oxygen (100%) administered 4 days per week, for 16 weeks, for the treatment of diabetic wound(s) will be measure and compared with standard of care (SoC) treatment. There will be a 2 patient groups (including a comparison group and a treatment group) including: (1) Patients will only receive standard treatment (2) Patients will receive standard treatment plus Topical Oxygen Therapy (TOT). All of the Topical Oxygen Therapy will be provided in a home care setting or extended care facility. 140 patients will be recruited.