A guiding principle for development of high-resolution metabolic analyses is that metabolic profiles in healthy individuals share common features while toxicologic and pathologic consequences of diet, disease, environment or genetics are reflected in variations in that metabolic profile. Studies in rodents show that characteristic patterns of metabolic change are associated with organ-specific toxicity for chemical agents that share no structural similarity (23-24). If this approach is extended to humans to identify healthy and unhealthy metabolic profiles, such patterns could provide a powerful new approach to identify and diagnose toxicities associated with chemical mixtures and diet-drug interactions. This proposal is to conduct a pilot study to determine whether diet-drug interactions can be detected in metabolic patterns of healthy adult subjects.