Study Procedures If subjects meet the inclusion and exclusion criteria and agree to participate in the study, they will be asked to complete the questionnaire (20 minutes): the Stage of Change algorithm will determine stage or readiness for change, pros' and con's of change will be assessed using the Decisional Balance Scale, smoking self-efficiency will be measured using the Self-Efficacy and Temptation Scale, and psychological distress will be measured using the Stop-D Scale (see questionnaire attachment in 9.1). The answers to the questionnaire provide information about the phenotype - who responds to varenicline (Champix) and IVR treatment and who does not.