So far there has been no consistent improvement in survival using this approach, although two recent studies suggest that a survival benefit might actually occur[3, 4]. However, there is consensus that patients who receive neoadjuvant chemotherapy and who achieve a "pathological CR", meaning that no tumor is found at time of definitive tumor resection, have experienced longer survival[5-8]. Perhaps with a more active neoadjuvant combination a significantly higher pathological CR rate can be obtained, and thus longer survival achieved.