3. Patients who currently have or have a history of the following within 6 months preceding study entry are not eligible: Unstable angina (UA), myocardial infarction (MI), transient ischemic attack (TIA), stroke, deep vein thrombosis (DVT), acute peripheral or pulmonary arterial thromboembolism (PE). Clinically significant ventricular arrhythmias (e.g., ventricular tachycardia, ventricular fibrillation, or torsades de pointes). New York Heart Association class III or IV heart failure.