Revision surgery for the purposes of this study is defined as any surgery on the injured leg (between the knee joint and ankle joint) more than 14 days after the accident, except operations designed to provide initial skin coverage or skin closure, or the removal of an external fixateur as an isolated procedure. Revision surgery will be classified as minor or major. Minor revision will be defined as dynamisation of an intramedullary nail through the percutaneous removal of a static locking screw. Major revision surgery will include all other revision surgery as defined above. Major revision surgery will be sub-classified as procedures involving either bone grafting, and/or revision of fixation, and/or for the treatment of established infection, or amputation, and the rates will be compared across treatment and placebo arms.