Specific aim The objective of this study is to assess the norepinephrine and serotonin reuptake inhibition capacities of levomilnacipran using the tyramine pressor procedure and blood platelet model respectively. Two control groups will be included to demonstrate the validity of the two experimental approaches, an active comparator group, and a placebo group. Therefore, there will be three treatment arms: 1) 12 participants will be administered escalating doses of levomilnacipran, 2) 12 participants will be administered escalating doses of duloxetine, and 3) 12 participants will receive levomilnacipran placebo-match capsules. Duloxetine will be used as an active comparator as it is an established 5-HT reuptake inhibitor and a potentially effective NE reuptake inhibitor.