A separate albeit related factor mediating LVH is obesity. Importantly, dapagliflozin has been shown to reduce weight. Thus the ideal treatment to regress LVH might be one that not only improves glycaemia but one that also aids weight loss. Dapagliflozin is the obvious option here since it has been shown to reduce both glycaemia and weight. Metformin is the only other anti-glycaemic which reduces both glycaemia and weight. Indeed the reason metformin reduces CV events in diabetes while other anti-glycaemic agents do not could well be in part because metformin reduces both glycaemia and weight which then reduce LVH (in fact we already have a separate British Heart Foundation grant to see if metformin really does reduce LV mass).