A non-invasive tool for measuring PaCO2, such as the SenTec monitor, can help decrease blood draws, thereby decreasing the incidence of iatrogenic anemia and the need for neonatal blood transfusions. Blood samples are collected through arterial lines, capillary heel sticks, or peripheral arterial punctures which are invasive and can be painful for the patient and may potentially result in injury. Although an ABG in neonates typically only requires 0.3mL-0.5mL of arterial blood, the need for frequent ABG sampling (every two to six hours) may result in a significant amount of iatrogenic blood loss. A newborn has a total blood volume of only 80mL/kg. In addition, the transcutaneous sensor has potential monitoring advantages as measurements are continuous rather than representative of a single point in time, as seen in ABGs. Continuous monitoring can help to avoid fluctuations in CO2 levels which can potentially result in neurologic injury in preterm babies, such as intraventricular hemorrhage and periventricular leukomalacia. One of the most beneficial aspects of the SenTec monitor is that it displays CO2 levels in real time, allowing clinicians to monitor trends and to intervene sooner if needed.