Outcome Differences: Differences between the plasma exchange and control groups, with respect to the primary composite and secondary outcomes at 6 months, will be evaluated by Pearson’s Chi-square. The time to death by treatment groups will be evaluated by Kaplan-Meier survival analysis using a log rank test for differences between groups. Uni- and multi-variate modeling of the primary composite outcome will be conducted by means of logistic regression, to determine for plasma exchange the unadjusted and adjusted odd ratios for the selected baseline determinants of chemotherapy, dialysis, age, urine protein, serum albumin and Durie-Salmon stage.