Progesterone has been used for many years to treat a variety of medical conditions. Side effects ascribed to its use alone are minimal. Minor adverse reactions include temperature elevations of 1 degree Fahrenheit, mood changes (depression following drug withdrawal), vaginal, cervical and uterine lining changes, irregular vaginal bleeding or amenorrhea, hyperventilation, mild fluid retention, a transient increase in low density lipoprotein (LDL), a transient decrease in high density lipoprotein (HDL), interference with lactation during breast feeding, nausea, abdominal cramping, dizziness, headaches, breast pain, and a delay in fertility. Most of these effects are associated with prolonged administration of progesterone (i.e., weeks to months). They are unlikely to be experienced during short-course administration (i.e., 3 days).