3. Day 0: After describing the study and initial verbal consent, medical history will be obtained and a thorough physical examination will be performed by a physician that will include measurement of the vitals signs. Once all eligibility criteria are met,the participant and in case of children the parent will be asked to sign the informed consent form. A blood and stool sample would be collected for determining the baseline immunological assay for immune responses. Following this, the participant will be allocated to the study intervention according to the randomization list (vaccine or placebo). Voluntary and solicited reactogenicity will be assessed symptoms and immediate adverse events recorded with 1 h of intake of the study agent. The participants will then be allowed to go home