Adverse events requiring treatment can be treated according to local prac¬tice. If there is a clinical indication for any additional medication during the course of the study, including medication given to treat an adverse event related to the study medicine, the name of the medicine, the dosage and the date and time of administration must be recorded on the case report form. Additional prescriptions may be given on enrolment or during follow-up for conditions other than malaria, although antibiotics with anti-malarial activity (cotrimoxazole, tetracycline except for eye ointment, doxycycline, erythromycin, clindamycin, azithromycin) will not be prescribed unless no equally effective alternatives are available. Any such prescriptions will be noted carefully.