More specific, there are at least three main paths that lead to carcinogenesis of colorectal lesions: the way of chromosomal instability (CIN), the path of microsatellite instability (MSI) and finally the path of methylated phenotype of the islands of cytosine-phosphate-guanine (CpG island) known as CpG Island Methylation Pathway (CIMP). After long-term studies, it has been found that in every path there is a participation of genes through their mutations and/or their epigenetic changes.