There are only three non-profit institutions that provide testing for recessive OI, our lab the Section on Heritable Disorders of Bone and Extracellular Matrix at the NICHD, the Genetics department lab at Baylor College, and the Pathology Department at Washington University in Seattle. Additionally, tissue specimens donated by volunteers for the purpose of serving as normal control samples will also fall under this protocol. This will enhance the ability of confirming a diagnosis of an affected proband.