4. History of GI obstruction/perforation, pheochromocytoma, seizure disorders, creatinine clearance less than or equal to 50mL/min (estimated creatinine clearance = [weight (Kg) x (140-age) x (0.85 if female)]/[72 x (stable creatinine)], Parkinson's disease, breast cancer, clinically active depression, or hypertension due to pheochromocytoma