On the basis of a small number of studies intravenous propofol has now been advocated for the treatment of chronic daily headache22-24 It seems fair to conclude that the existing strife to promote propofol as an effective intervention for treating CDH in the absence of a randomized controlled trial merely reflects the lack of a single good treatment option for this condition. It is, furthermore, reasonable to speculate that the beneficial effect seen with propofol is a placebo response. Krusz et al reports the effects of subanesthetic doses of intravenous propofol on chronic migraine in a cohort of 77 subjects in an open-label study22 Propofol was administered by intermittent boluses; the average dose used was 110mg. It is reported that 63 out of 77 patients reported complete abolition of their headache with an average time of 20 - 30 minutes of propofol treatment. The range of propofol doses used is however not clearly stated and there was no assessment of the intervention beyond 24 hours. In this study lidocaine was mixed with propofol to reduce the pain of injection but it could not be said with any certainty that lidocaine itself has no effect on headache.