Previous Study 3. In the study conducted, we combined HFL-TMS and LFR-TMS sequentially in each treatment session in a trial comparing active to sham stimulation (n=50, 25 per group). Importantly, treatment was provided for up to 6 weeks, longer than any previously published rTMS trial. In this study there was clearly a marked benefit of active over sham stimulation. There was a significant difference between the groups at 2 weeks (F(1,25)=25.5, p<0.001) which remained significant at all other trial time points (F(5,44)=3.9, p=0.005). Patients continued to respond across the 6 weeks of active treatment.