MIUA should be performed after cervical ripening. This pre-surgical procedure makes the procedure safer and more effective. In Brazil, misoprostol is the most suitable drug to be used in these cases because of its efficacy, easy of use, low cost, stability at room temperature and availability. Misoprostol is a synthetic prostaglandin E1 analogue and can be administered by oral, sublingual, buccal, rectal and vaginal routes.