The Independent adjudication committee (IAC) has the following roles: A. Blinded review of clinical events (IAC- function), i.e. all suspected recurrent thromboembolic events, bleeding of any kind, any vascular events and all deaths during the study period and the observational period will be evaluated by IAC .The study nurse will provide the IAC with all relevant documentation related to the events but the IAC will be blinded as to the monitoring method of each patient while evaluating events. Adjudication results will be the basis for the final analyses. and B. Data safety and monitoring (DSMB-function), i.e. this committee also has the responsibility to provide the EXC with recommendations related to the protection of the patients' safety, including stopping recruitment and stopping the study. For this purpose, the DSMB will review all incidences of recurrent thromboembolism and bleeding every 3 months, see Chapter 11.