3. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ＞2.0 times the upper limit of normal (ULN), or alkaline phosphatase (ALP)＞1.5×ULN, or Total bilirubin (TBIL) ＞1.5×ULN, creatinine clearance rate＜60 mL/min;