For brain tumors, most of studies were focused on the role of angiogenesis inhibitors. Of special interest, anti-VEGF therapies, particularly the bevacizumab, were tested in clinical setting. Bevacizumab, a monoclonal recombinant antibody targeting VEGF, prevents the fixation of VEGF to VEGF receptors 1 and 2 on the endothelial cells, with a neutralizing effect on VEGF action.