PCa also has a highly heterogeneous potential of evolution. While some cancers will behave in an aggressive manner, other patients will have an indolent form of the disease that could not require any treatment. Several parameters are used to predict the risk of evolution in PCa patients, either before any treatment: clinical stage, Gleason score on biopsies, and serum prostatic specific antigen (PSA), or after the analysis of radical prostatectomy specimens: pathological stage and surgical Gleason score (5). However, despite the value of these prognostic factors, the potential of aggressiveness remains difficult to assess at diagnosis, and patients classified within the intermediate risk group are often difficult to manageThere is a challenge to discover new markers and novel targets for early therapeutic manipulation.