Computer-based training strategies have been developed to train and rehabilitate various cerebral functions such as language learning deficits. Computer-based training has also been extensively studied as a treatment for partial blindness in adult brain-injured patients (Kasten et al., 1998; Sabel and Trauzettel-Klosinksi, 2005; Sabel et al., 2005). However, the neurophysiological mechanisms underlying the reported beneficial effect following VRT remains poorly understood. One important issue is that if the restoration of visual field and function is the result of localized neuroplastic changes in cortical circuitry within visual cortex, one can posit that modulation of cortical excitability should in turn influence the degree of this restorative effect. More specifically, increasing the level of overall cortical excitability of the visual cortex should potentiate synaptic neuroplastic interactions and thus translate into improved visual functional gains.