In this study, a total of 30 participants will be randomly assigned into 3 groups. Randomization will be conducted using the University of Pittsburgh Cancer Institute (UPCI) randomizer, which is maintained by the Biostatistics Facility of UPCI (https://randomize.upci.pitt.edu/randomizer/home.seam).10 participants will serve as a control group, and will receive neither 5FU injection nor topical imiquimod. In another 10 participants, intralesional injections of 50mg of 5FU in 1ml aqueous injectable solution will be administered weekly for 3 weeks. In yet another 10 participants, intralesional 5FU will be administered as in the previous group, additionally participants will also receive concomitant three-times-weekly topical application of 5% imiquimod to the same lesion. At the end of week two, a 2mm punch biopsy of the lesion will be obtained for mid-point analysis, and will be stored for tissue banking and future study. A week after the last injection (week 4), the lesion will be surgical resected in all participants including the control group, to render the patients disease free. Resection is the current standard of care for these tumors. A part of, or all of, the resected tumor and surrounding skin will be stored for tissue banking and future studies to characterize and compare the tumor microenvironment before, during, and after therapy.