Methodology: Randomization: Patients identified by the Acute Stroke team as candidates for EVT will be referred to the study anesthesia team for consideration as study participants. Only after anesthetic pre-procedural assessment is complete, as per usual standard of care, and clinical uncertainty exists as to the best anesthetic management will the patient be randomized. Sequence generation: Randomization will be performed using REDCap to allow central randomization from any hospital computer with internet access. The blocked randomization sequence list will be created in STATA. The randomization instrument will be created in REDCap separate to the data collection tool to ensure blinding allocation is maintained. All treating consultant anesthetists will have access to the REDCap randomization instrument. User rights will be set so that these clinicians do not have access to participant follow-up data. Details of each procedure (GA or sedation) are outlined below. The attending anesthetist will log-on to REDCap and access the Randomization tool. This process will take 2-3 minutes once trained in the randomization process.