E10. Prior exposure to any anti-PD-1 or anti-PD-L1 or anti-CTLA4 antibody E11. Known allergy or hypersensitivity to humanized antibodies E12. Pregnant or breastfeeding women E13. Persons deprived of their freedom or under guardianship, or for whom it would be impossible to undergo the medical follow-up required by the trial, for geographic, social or psychological reasons