Globally An estimated 140-250 million under-five children are deficient in vitamin A, which is associated with increased mortality and morbidity among this population. A relationship between the severity of vitamin A deficiency and childhood mortality has also been reported. In 2002, the United Nations held a special session to examine ways to eliminate this problem through various approaches including breast-feeding, food fortification, improved diet and supplementation. Periodic supplementation of a mega dose of vitamin A has been recommended to be a suitable intervention at the community level which is likely to improve the over all vitamin A status. This is also cost effective and patient compliant. This approach has resulted in reduction in all-causes of deaths among under-five children by 23% in areas where vitamin A deficiency is a major public health problem [3] (http://www.who.int/vaccines/en/vitamina.shtml accessed on 26 May, 2005 at 1300 hrs). In view of the public health importance of vitamin A nutriture, the Government of Bangladesh recommends the administration of 200,000 IU of vitamin A every six months to all children aged 12-59 months irrespective of their nutritional and vitamin A status (Institute of Public Health Nutrition. Field guide for National Vitamin A Plus Campaign, 2005).