The author has carried out a pilot, prospective, non-randomized, one-center, non-placebo-controlled study that enrolled a total of 219 patients with chronic bronchopulmonary pathology who have been followed up for 4 years. The study was conducted at a specialist consulting and diagnostic clinical center of the State-Funded Educational Institution of Higher Professional Education "Samara State Medical University" of the Ministry of Healthcare of Russia in collaboration with the Federal State-Funded Research Institute "Moscow Scientific Research Institute of Vaccines and Sera named after I.I. Mechnikov".