The trial will be performed to investigate the beneficial effects of RIC treatment on the study outcomes described below. The RIC treatment duration will be 12 weeks and 40 patients from the Steno Diabetes Center will be included in the trial. All tests and analyses will performed at Steno Diabetes Center expect for markers of inflammation and oxidative stress which will be performed at Dept. of inflammation, German Diabetes Center and institute of Clinical Diabetology, German Diabetes Center. All necessary facilities are available at the study sites.