Helping patients to support regular treatment is a crucial point in increasing compliance with treatment and thus increasing the cure rate, and many supportive care have been developed and implemented. Physical activity, now regarded as a non-drug therapy, provides many benefits, both in tertiary and secondary prevention during cancer treatment. Many studies have shown a decrease in mortality with physical activity during and after treatment, especially for breast, colon and prostate cancer. Regular physical activity during treatment increases patients' quality of life, for many types of cancer. The prevalence of fatigue during cancer is well described, as well as the need to effectively treat cancer related fatigue in order to enable patients to better withstand their treatment. Within the last decade, it has been pointed out that physical activity is one of the most efficient ways to combat cancer related fatigue.