5. Patients must have normal organ and marrow function (measured within 28 days prior to entry/ randomization) as defined below: a. Absolute neutrophil count >/= 1,500/mcL b. Hemoglobin>/= 9gm/dL c. Platelets >/= 100,000/mcL d. Total Bilirubin </= 1.5X ULN e. AST/ALT </= 2.5x upper limit of normal unless the liver is involved with tumor, in that case, ALT/AST must be </= 5x upper limit of normal f. Creatinine clearance >/= 50 mL/min (assessed by Cockcroft Gault estimation)