All results presented in the dissertation and abstract have been published in scientific papers and meeting abstracts. The author was personally involved in studying clinical, microbiological and immunological effects of vaccination against pneumococcal infection in patients with chronic bronchopulmonary pathology and the effect of different vaccination regimens on the dynamics of functional test parameters and the short- and long-term quality of life outcomes. He also developed a scientifically sound regimen for using the pneumococcal vaccines in patients with chronic bronchopulmonary pathology. The presence of a complete set of primary documents and sufficient statistical analysis of study results allows us to conclude that the data obtained are correct and conclusions and recommendations justified.