Subjects with confirmed active CD will then be randomized into two groups a) CE and b) IC plus MRE or IC alone (comparator group). In the comparator group, subjects with small bowel disease (proximal and/or ileal) and/or colonic disease with clinical indication (per investigator discretion) will undergo IC plus MRE. For subjects with no small bowel, MRE at 6 and 12 months is at the discretion of the physician.