20. Subject has a history of other malignancies prior to study entry, with the exception of: a. Adequately treated in situ carcinoma of the cervix uteri or carcinoma in situ of breast; b. Basal cell carcinoma of the skin or localized squamous cell carcinoma of the skin; c. Previous malignancy confirmed and surgically resected (or treated with other modalities) with curative intent or completed definitive therapy (chemotherapy, radiation, others) for the malignancy at least 1 year prior to the date of screening.