In two recent studies, the frequencies of ROP needing treatment as well as cholestasis were significantly reduced when a solution containing fish oil (SMOFlipid) was provided compared to Clinoleic in preterm infants with birth weight 1250 grams. In addition, ROP frequency was reduced in infants receiving SMOFlipid as compared to those receiving Intralipid. No randomized controlled trial comparing convention-al fatty acid administration without and with supplementation of AA and DHA from birth with regard to ROP has been published.