Background Antiepileptic Drugs And Cognitive Dysfunction Epilepsy is the most common debilitating neurologic disorder, with a prevalence of about 6/1000 in the general population (Hauser and Hesdorffer, 1990). Along with the disabling psychosocial and physical disadvantages that accompany epilepsy, medication concerns are frequently reported (Gilliam F et al. 1997). The majority of adverse events related to medications pertain to cognition (Baker GA et al. 1997).