Assessments to be Performed Pharmacodynamic and safety evaluations: At each visit, a catheter will be placed in the subject's antecubital vein. The participant will lie down and remain supine until his pulse is determined to be stable (+/- approximately 5 bpm) over two consecutive measurements made a minimum of 10 minutes apart. The subject's heart rate and blood pressure will be recorded from the arm contralateral to the catheter. Blood samples will be drawn from the catheter while the participant remains supine. The participant's heart rate and blood pressure will again be recorded from the arm contralateral to the catheter.