In both groups, women who are Rh negative will receive 120 :g Rh(D) immune globulin on Day 1. The methotrexate/misoprostol group will be given 50 mg/m2 methotrexate and both written and oral instructions. At least 72 hours after the methotrexate (Day 4-7), they will be asked to moisten four 200 :g tablets of misoprostol with a few drops of water each and insert them into the vagina. On Day 1, the misoprostol-only group will receive 400 :g misoprostol sublingually and the doctor will use a speculum and warm water to cleanse the vagina, moisten 400 :g misoprostol with warm water and place it in the vaginal fornices. All women will also be given six tablets of acetaminophen with codeine, two tablets of diphenhydramine, and six tablets of 400 mg ibuprofen to use for side effects.