Searches: Search in MEDLINE, EMBASE and SCOPUS databases for the literature published in English or Spanish from January 1970 to December 2015 of all prospective and retrospective studies performed with Stress Echo, SPECT, PET, CMR and CTP in patients with suspicion or known CAD compared against the reference standard of ICA (two cutoffs: lesions >50% and >70%) and/or invasive FFR (two cutoffs: <0.80 and <0.75).