Lung cancer is the leading cause of cancer death in men and women in the USA, and account for 28% of all cancer deaths in 2002 (1). In stage IV and some patients with stage III disease chemotherapy is widely used with the primary aim of prolonging survival and /or palliating symptoms. A meta analysis of clinical studies that randomized patients between the best supportive care and chemotherapy concluded that Cisplatin based chemotherapy resulted in a potential gain in the median survival and an increase of the 1-year survival rate compared to the supportive care alone (2). Combination chemotherapy regimens (Platinum/Taxanes, Platinum/Gemcitabine, Platinum/Vinca alkaloids) have demonstrated a response rate of 30-50% with median survival of approximately 10 months, one year survival rates around 40%, and 2 year survival of only 10 % in patients with advanced Non Small Cell Lung Cancer (NSCLC) (3,4). Therefore it is important to continue to search for new agents/combinations that can be used to improve the overall prognosis of these patients.