Perinatal stroke affects more than1 in 2,300 live births. Perinatal stroke is the most common cause of hemiparetic cerebral palsy (CP). Even with prompt behavioral therapy, ongoing significant residual motor impairments are common in these children. In this case, innovative interventions that take advantage of the early critical window for optimizing outcomes are urgently needed—in infancy. Thus, understanding the early brain reorganization before the brain has not yet largely reorganized is critical for developing efficacious early intervention.