Analysis Between group demographic factors that will be examined and controlled for will include age, gender, education level (years), and socioeconomic status using independent samples t-tests.48 All analyses will be conducted on an intention to treat basis. The average absolute difference between the baseline and post-treatment HDI scores for the two infusion groups will be compared using analysis of variance (ANOVA). We will compare the changes in NRS scores between the two infusions groups over time using repeated measures ANOVA. Any demographic factors found to be significantly different between groups will be included as covariates in this analysis. All t-tests will use Bonferroni corrections to control for the inflation of alpha.