Intravenous monthly administration was carried out. The initial dose was 120 mcg, 200 mcg or 360 mcg, provided that patient had previously received a weekly dose of Epoetin alpha/ beta of less than 8000 IU, between 8000 to16 000 IU or more than16000IU respectively. Doses of C.E.R.A. were adjusted according to protocol and not more than once monthly.