2. Pharmacokinetic Analysis: Pharmacokinetic parameters will be determined from plasma drug and metabolite concentration curves using non- compartmental approaches. Mean (SD) plasma drug concentration values will be summarized and plotted for each dose group. All parameters described will be summarized with means and standard deviations. The concentration in plasma determined at each sampling time point will be furnished on the original scale for each subject participating in the study. The pharmacokinetic parameters Cmax, Cmin, Cave, and AUC will be analyzed on the logarithmic scale of measurement. The parameters of elimination half- life and tmax will be analyzed on the original scale.