30 healthy adult males will be randomized to receive a single dose of metformin hydrochloride SR (1000mg) in fasting state or metformin hydrochloride SR (1000mg) in fed state or a fixed dose combination of metformin hydrochloride 1000mg SR /glimepiride 2mg tablet in fed state in each treatment period. There will be 6 treatment sequences and a washout of 7 days between each of the three treatment periods.