Methods: Patients with a first STEMI, candidates for PPCI, with left anterior descending artery (LAD) culprit lesion, and CWP>38mmHg, with continuous elevation of the pressure line will be randomized, by a 1:1 model, either to cortisol therapy or to placebo. Inflammatory parameters will be determined from peripheral blood samples. Patients will undergo cardiac magnetic resonance (CMR) imaging 3 to 5 days after revascularization.