Hyper-CVAD therapy will be given during the odd-numbered courses (1, 3, 5, and 7). You will receive cyclophosphamide by vein on Days 1-3, which will be given every 12 hours for a total of 6 doses. While you are receiving cyclophosphamide, you will also receive MESNA by a central venous catheter (CVC), which will be given over 24 hours until about 12 hours after your last dose of cyclophosphamide. This drug is used to help protect your bladder from the side effects (such as irritation and bleeding in the bladder) of cyclophosphamide. A CVC is a sterile flexible tube that will be placed into a large vein while you are under local anesthesia. Your doctor will explain this procedure to you in more detail, and you will be required to sign a separate consent form for this procedure. You will receive vincristine by vein on Days 4 and 11, which will be given over 30 minutes during each cycle of hyper-CVAD therapy. You will receive doxorubicin on Day 4 through a large vein by a CVC over 24-48 hours after your last dose of cyclophosphamide. This will depend on your heart function because the drug is being given over such a long period of time. You will receive dexamethasone on Days 1-4 and Days 11-14 by mouth or by vein over 30 minutes during each cycle of hyper-CVAD therapy.