In the next stage, an in vivo test will be performed. The temporary cement without the supplement will be placed under the provisional restoration. After a week an impression of the finishing line, And the mesial and distal walls will be taken upon a gum with sugar. The cement will be replaced with the same kind of cement, but with the IPN supplement, and will be impressed in the same manner a week later. After each appointment (2 for each patient), the gum impression will be placed on a selective S.mutans media (Mitis salivarius bacitracin,MSB( for 48h, at °37 C. Using the image-pro program, the concentration of the bacteria per area will be determined. In this way we will estimate the antibacterial activity of the supplement in the cement.