2. IV Lidocaine infusion dose and toxicity (2,3,4,5,6,7,10). Lidocaine toxicity does not occur with plasma levels below 5 mcg/mL. Currently reported dosing vary between 'no IV bolus' to 3 mg/kg/hr IV bolus followed by 1.5 to 3 mg/kg/hr infusion rates. These doses generally result in plasma levels of 1.3-3.7 mcg/mL. There is no increase in local anesthetic toxicity at these plasma levels compared to placebo. In one study up to 2.6 mg/kg/hr of lidocaine had been infusing for 24 hours after the end of surgery with no reported side effects attributed to local anesthetic toxicity (4).