What are the proposed practical arrangements for allocating participants to trial groups? Patients will be randomized (1:2:2) to placebo, Advair, or Flovent. Patients will first be stratified based on study site to minimize the potential impact of variation in patient care across the study sites on the endpoint of interest. We have hired an external statistician (Ms. Lieling Wu) who will prepare computer-generated randomization lists blocked by study site using permuted blocks of six. The lists will be inputted into a randomization computer. When a site coordinator has identified an eligible, consented patient, he/she will contact the central co-ordinating site at St. Paul’s Hospital (SPH) for a randomization number. The randomization computer will then issue a study identification number to the study coordinator and to GlaxoSmithKline (Mississauga) for delivery of the appropriate treatment package (that contains one Flovent canister and one “unknown” puffer) to the appropriate study site within two business days. The open-labeled Flovent will be used for the “run-in” phase, while the “unknown” puffer (either placebo, Flovent or Advair) will be dispensed at the start of the “active treatment phase.”