Since Gefitinib is not available now for wider use, we are proposing a study of erlotinib with hypofractionated RT in a Phase II setting with the main objective of assessing efficacy of such a combination. There is no direct evidence that patients receiving concurrent EGFR inhibitors and RT need to be pre-selected with regard to the EGFR status. In a recent study (Bentzen SM et al, 2005), positive immunohistochemical staining for EGFR status was associated with a benefit in locoregional control in patients with head and neck cancer receiving CHART (continuous hyperfractionated accelerated radiotherapy), but the EGFR status had no effect on survival or rate of distant metastases. Therefore, we propose to investigate the EGFR status in all eligible patients, but to treat them without selection for the EGFR status.