Assessments will be performed according to the schedule of events in section 4.1. Blinded examiners will be utilized for the EDSS, MSFC and low contrast visual acuity assessments. Lab results for B cell CD19+ counts will be collected by a blinded study coordinator who will have them reviewed on a monthly basis by a qualified member of the DSMB for safety assessment. But the CD19 B cell counts will not be available to the treating clinician unless needed for safety.