Assuming there is a correlation between high cytokines levels during inflammation and the severity of radiation induced mucositis, finding these prognostic factors may help us predict during the first part of the treatment the need for PEG, placing it prior to the complications associated with severe mucositis on one hand, and avoiding unnecessary procedures on the other hand. This study may also lead to a new strategy of assessing severity of mucositis by laboratory tests, a tool that can be used as an objective assessment in developing strategies that aim to reduce the mucositis. The understanding of the cytokines balance in this condition can also be translated to the use of anti-cytokine treatment for this condition, similar to other immune related diseases such as RA, Crohn's Disease and MS.