Clinical management of cardiovascular disease in individuals with MFS aims to decrease the rate of aortic root dilation and reduce the risk of dissection and rupture. Beta blockers (eg. Atenolol) have been the traditional medical treatment although some studies have cited the success of calcium antagonists or angiotensin converting enzyme (ACE) inhibitors, However, while beta blocker treatment has been successful in reducing the rate of dilation of the aorta, and its complications in MFS, studies report inconsistent responses to treatment and one pediatric study showed no benefit of beta blockers and better results with ACE inhibitors. Thus, it is still unclear whether one or the other of these pharmacological agents improves outcomes in regard to aortic dilation or rupture.