Carmustine, etoposide, cytarabine, and melphalan are designed to kill lymphoma cells by inserting into the cell DNA. Rituximab is a monoclonal antibody that targets a specific marker on the surface of lymphoma cells and causes it to die. Bortezomib works by blocking proteasomes, which are clusters of proteins necessary for cancer cell growth. Cancer cells may be sensitive to drugs like bortezomib because tumor cells have more proteins than normal cells. Bortezomib enters the tumor cells and affects the way they divide. When cancer cells cannot divide, they die.