Intravitreal aflibercept is the next generation of anti-angiogenesis treatments which also introduces a new proactive every-other-month treatment regimen (after 3 monthly injections) in the first year, followed by individually extended treatment intervals afterwards. Aflibercept is a fusion protein consisting of portions of human VEGF receptors 1 and 2 extracellular domains fused to the Fc portion of human IgG1. It is purified and formulated as a solution for intravitreal use. As such, aflibercept acts as a soluble decoy receptor that binds VEGF-A and PlGF with higher affinity than naturally occurring VEGF receptors. Thus aflibercept competitively inhibits VEGF-A and PIGF binding to the cognate VEGF receptors and their activation.