Sampling matrix Participants will be enrolled in three groups according to their primary therapy (A. Surgery, B. Radiochemotherapy, C. Targeted therapy). Various combinations of therapies are permissible, resulting in a total of eight subgroups (A.1 Surgery alone and/or before any adjuvant therapy, A.2 Surgery [late effects], B.1 Chemotherapy alone, B.2 Radiotherapy alone, B.3 Sequential radiochemotherapy, B.4 Concurrent radiochemotherapy, C.1 Targeted therapy alone, C.2 Targeted therapy in combination with any other therapy, D. Immunotherapy).