After completion of the surgical procedure, all subjects will remain at the clinic for at least 3 hours and will be continuously monitored for safety. At the discretion of the investigator, subjects may receive rescue medication (opioid or non-opioid) upon request for the management of breakthrough pain and may receive an antiemetic for the management of nausea or vomiting. After the initial 3 hour period, subjects who are deemed stable can be discharged to the hospital ward. Subjects will remain housed in the hospital ward for at least 48 hours. Blood samples will be collected from the subset of 8 children in each age group after INL-001 is implanted for pharmacokinetic analysis.