Every patient will be instructed to download on his smartphone an application that will remind him to take Regenium in the morning and in the evening; secondly the clinician will call the patients two weeks after T0 and two and five weeks after T1, with the pretext to remind the next appointment and to have information about their oral health, but with the real intention to remember and to verify the regular assumption of Regenium. Lastly, at T2, patients will have to bring back the blister, also the empty ones, for the pill counting.