The study population comprised 4,243 non-Hispanic Blacks, including 3,837 U.S.-born (90.4%) and 406 foreign-born (9.6%). Compared to U.S.-born Blacks, a higher proportion of foreign-born Blacks were male, had attained a higher level of education, were classified as normal or overweight, had never been a smoker, engaged in physical activity, and had lower energy intake. In comparison to those who were in the U.S. for <10 years, more foreign-born Blacks who were in the U.S. for ≥30 years were current smokers (14.8% vs. 5.0%, respectively), had higher income (IPR of ≥4.00: 43.5% vs 7.9%, respectively), and a higher percent with a college degree or higher (39.4% vs. 18.3%, respectively). Foreign-born Blacks residing in the U.S. for ≥30 years reported higher BMI in comparison to those residing in the U.S. for <10 years (28.8 vs. 26.7 kg/m2).