Introduction Central venous catheter (CVC) insertion is a very common procedure in the intensive care setting. A recent international guideline advocates the use of ultrasound for routine internal jugular central venous catheter insertion1. The needle navigation technology is a new innovation, also known as guided positioning system (GPS) which allows clinician to visualize the needle position and trajectory in real time as it approaches the target. We hypothesised that the use of GPS would increase success rate and decrease performance time in vascular access procedures. The objectives of this study are to compare the success, efficacy and safety of central venous catheter insertion via internal jugular vein using the ultrasound guidance with conventional method versus needle navigation technology.