Plerixafor is a small molecule that inhibits chemokine stromal cell derived factor 1-alpha from binding to CXC chemokine receptor 4, resulting in increased hematopoietic stem and progenitor cell migration into peripheral blood circulation. Plerixafor use in combination with G-CSF has resulted in significant improvements in the mobilization outcomes of MM patients. Despite the promising results of plerixafor and G-CSF for PBPC mobilization, the use of chemotherapy-based mobilization regimens remain standard practice in many transplant centers, driven in part due the costs associated with plerixafor based strategies.