- Myeloablative therapy/transplantation: Patients receive thiotepa IV over 3 hours on days -8 to -6, topotecan IV over 30 minutes on days -8 to -4, and carboplatin IV over 4 hours on days -5 to -3. Patients undergo autologous or syngeneic bone marrow transplantation (BMT) or PBSC transplantation (PBSCT) on day 0.