Activity and side effects of the combination docetaxel-carboplatin in breast cancer The combination of carboplatin and docetaxel has been extensively studied mainly in ovarian and lung cancer. Doses of AUC 5-6 of carboplatin in combination with 75 mg/m2 of docetaxel are easily combined, being myelosuppression the most important toxicity. This combination has been studied in metastatic breast cancer as well as in the neoadjuvant setting.