Rationale: Stroke is a leading cause of adult morbi-mortality worldwide. Intravenous (IV) recombinant tissue plasminogen activator (rtTPA) was the only therapeutic option for many years. After the publication of five randomized controlled trials, guidelines for stroke treatment were updated and released in 2015. According to these guidelines, in addition to IV rtTPA, endovascular therapy (EVT) for acute ischemic stroke (AIS), secondary to proximal intracranial arterial occlusion, has become established as an international standard of care (Avitsian & Machado, 2016). Management of patients undergoing stroke is complex due to the association of acute neurological physiological changes and pre-existing co-morbidities. To facilitate efficient and safe delivery of endovascular treatment, patients require anesthetic intervention in the form of sedation or general anesthesia (GA). The choice of anesthetic technique is often guided by individual patient factors and personal clinician practice (Dhakal, Diaz-Gomez, & Freeman, 2015). Two recent meta-analyses (Brinjikji et al., 2015) have found an association of better functional outcome related to endovascular procedures performed under sedation compared to general anesthesia. The interpretation of current data is challenging as most studies are retrospective and performed under direction of non-anesthetists with poor definition of anesthetic techniques. A prospective controlled randomized trial is required to demonstrate the influence of anesthesia techniques on functional outcome. Prior to commencing this large trial, the investigators will execute a feasibility study (GASTROKE-pilot), which is outlined here. Following confirmation of feasibility, the full prospective randomized controlled trial will take place using the same study methodology.