Safety data were recorded with glioblastomas are reassuring, however, it is essential to determine the optimal dose level of bevacizumab when combined with irradiation of the entire brain at a dose of 30 Gy Thus for the phase 1 pilot study that we plan to carry, it is important to test several dose levels of bevacizumab in combination with irradiation of the brain: a precaution we have decided to use a conventional fractionation of 15 Gy in 2 fractions three weeks. Secondarily, given the good tolerability of this modality in combination with three levels of dose of bevacizumab used, we propose to continue the phase 1 according to the scheme commonly used in palliative situation (30 Gy in 10 fractions and 2 weeks) in combination with Avastin at a dose of 15 mg / kg, at which a maximum limiting toxicity has been observed.