- Has active autoimmune disease that has required systemic treatment in the past 2 years (ie, with use of disease modifying agents, supra-physiologic doses of systemic corticosteroids or immunosuppressive drugs); replacement therapy (eg, thyroxine, insulin; or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment; asthma; type I diabetes mellitus; hypothyroidism; and vitiligo are allowed