14. ADDITIONAL EXCLUSION CRITERIA FOR PATIENTS IN COHORTS 1 and 2 (cobimetinib-containing cohorts): Cardiac Exclusion Criteria: a. Unstable angina, or new-onset angina within 3 months prior to initiation of study treatment b. Symptomatic congestive heart failure, defined as New York Heart Association Class II or higher c. Myocardial infarction within 3 months prior to initiation of study treatment d. Left ventricular ejection fraction below the institutional lower limit of normal or below 50%, whichever is lower