The investigations were those commonly used in clinical trials and included physical examination, laboratory, immunological and microbiological investigations, assessment of functional tests and health-related quality of life parameters in dynamics including a short-term (one-year) and long-term (four-year) follow-up in adult patients with chronic bronchopulmonary pathology (e.g., chronic obstructive pulmonary disease, bronchial asthma) against the backdrop of using different pneumococcal vaccination regimens.