In summary, lithium has been proven to significantly modulate the magnitude of the expression of a number of genes, among which the most robust and replicated changes were for BCL2, BAX, p53, and SAT1. Thus, we can take advantage of the well-established property of lithium of regulating the expression of these genes, and proteins, in a significant and stable manner. Conversely, these genes could be used as markers of the effect on lithium on the gene expression, providing a measure for the investigation of the effectiveness of EBV immortalization and repeated passages in eliminating the in vivo treatment effects.