The routine use of computed tomography (CT) has increased substantially since its introduction into medicine, which, in turn, has also increased the amount of radiation to which individuals are exposed. This increased radiation is not without risk and is particularly problematic in our primary immunodeficiency disease population, who require serial imaging with chest CTs to manage pneumonia. Standard medical practice in this patient population is to diagnose infection by obtaining a diagnostic CT and then repeating the CT every three to four weeks until the lesion has resolved in order to guide the treatment course.