This is a multicentre clinical trial to evaluate safety and efficacy of renal denervation system in treatment of hypertension. Hypertensive patients who meet enrollment criteria will be randomized into treatment group who will receive standardized drugs and renal denervation treatments, or control group who will receive standardized drugs and a sham procedure (renal artery angiography only without denervation). The patients will be monitored for blood pressure changes and any adverse events for 6 months. The safety and efficacy of the device will be evaluated by comparing blood pressure levels and adverse event episodes between the two groups.