- Physiological Model for End-Stage Liver Disease (MELD) ≥30 at screening visit. MELD score is calculated using a patient's values for serum bilirubin, serum creatinine, serum sodium, and the international normalized ratio for prothrombin time (INR). This version of the MELD calculation (MELD-Na) is the United Network for Organ Sharing (UNOS) 2016 modification of the original model to include serum sodium as a factor.