Significance: The results of this study will provide important new knowledge about mechanisms underlying cognitive enhancement strategies in SCZ. That is, the investigators intend to decipher the complex pharmacological mechanisms that underlie nicotinic cholinergic enhancement of plasticity in the DLPFC. Such findings will also help to generate important biomarkers through which cognitive enhancing strategies may be measured biologically that can potentially lead to the development of more personalized treatments of cognitive deficits in this debilitating disorder.