All eligible patients will be enrolled, without regard for the EGFR status. The implications of prospectively screening patients for EGFR mutations or gene copy number and how the patients should be selected for subsequent treatment remain to be defined (Janne P et al, 2005; Shepherd f et al, 2005). Therefore, patients will not be excluded from trial participation based on the EGFR testing. The EGFR status will be assessed by the FISH assay in biopsy or resection tissue samples and the test will be performed by a commercial laboratory.