A total of 52 patients with international society of Nephrology/ renal pathology society (ISN/RPS) class III to V lupus nephritis were screened, 3 of which did not meet entry criteria and 49 patients were enrolled in the study comprising of 25 and 24 patients in the MMF and CYC group respectively. Twenty one patients in each groups could complete the study till the end of 6 months and were included for analysis.