- ADT with surgical castration with bilateral orchiectomy or medical castration with LHRH agonist or LHRH antagonist therapy may have been initiated no greater than 84 days (12 weeks) prior to study consent and no greater than 112 days (16 weeks) prior to enrollment date. However, patients are not eligible if PSA has risen >=25% and >= 2 ng/ml above nadir value since initiation of ADT prior to consent.