Abstract: according to data from the literature, a balanced diet combined with moderate exercise helps to fight against biological complications related to obesity and to reduce the incidence of type 2 diabetes by promoting fat loss. But there is no consensus on the intensity of physical activity prescribed. Have been shown the benefits of training performed at an individualized intensity of effort, relatively low, corresponding to the maximum rate of lipid oxidation measured by indirect calorimeter (LIPOXmax) on fat loss, sensitivity to insulin and muscle metabolism in obese or diabetic patients. However, an individualized LIPOXmax exercise training has not yet been compared to a standardized training conventionally used in the treatment of obese subjects. Furthermore, no study has yet evaluated the impact of LIPOXmax training on inflammatory and antioxidant status among overweight and obese patients. We propose to compare among overweight or obese patients, the effects of an individualized training at an intensity corresponding to LIPOXmax, the effects of a standardized training to 60% of VO2max, and the effects of a moderate and regular physical activity prescribed according to guidelines of Good Medical Practices.