A successful MDA with gametocytocidal drugs could serve as a proof of principle for a transmission blocking vaccine. A MDA study is expected to have a similar impact on malaria transmission as a TBV: while the contact between man and mosquito is not influenced, the infectiousness of the human population to mosquitoes is reduced. Because of this similarity, both need identical evaluation tools. An MDA can therefore be used to test the sensitivity and suitability of clinical and biological measures.