COPD Co-Pilot AIRTM combines a digital respiratory symptom reporting subject application (an "app") with facilitation of rapid personalized clinical recommendations made by the subject's health care provider and communicated to the subject through the application. COPD Co-Pilot AIRTM provides early identification of an increase in a subject's respiratory symptoms relative to the subject's own baseline symptom profile which in turn enables health care providers to rapidly implement modified treatment plans.