The EORTC QLQ-C30 comprises 30 items that are grouped in five functional scales (physical, role, cognitive, emotional and social), one scale to rate global health and quality of life, three multi-item symptom scales (fatigue, nausea and vomiting, pain) and five single symptom items (dyspnoea, insomnia, appetite loss, constipation and diarrhea), one item assessing perceived financial impact of disease and treatment [18]. Patients rate items using a four-point Likert response scale with the exception of the scale on global health and quality of life which is accompanied by a seven-point response format. A time period is not specified for the physical functioning scale items. The time frame for all remaining items is the past week.