Patients who are her-2 overexpressors by FISH will also receive trastuzumab with weekly carboplatin and paclitaxel since this combination has been found to be synergistic in advanced breast cancer with improved clinical outcome. In a small study, higher pathological response rates were achieved in patients who received trastuzumab with chemotherapy compared to chemotherapy alone in the neoadjuvant. This study had a total of 34 patients who completed therapy. One arm received neoadjuvant chemotherapy with four cycles of paclitaxel followed by four cycles of fluorouracil, epirubicin, and cyclophosphamide. In the second arm, the patients received the same chemotherapy regimen with the addition of trastuzumab on a weekly schedule for twenty-four weeks. A pCR was achieved at 65.2% in the trastuzumab plus chemotherapy compared to 25% in the chemotherapy alone arm.