An additional phase II study with the same schedule was performed, as first-line chemotherapy in 32 patients (30 female, 2 male) with metastatic breast cancer. An ORR of 62.07% (8 CRs, 10 PRs) was reported; five patients (17.24%) had progressive disease. Grade 3 toxicities included neutropenia (24%), anemia (15.6%); nausea, vomiting, fluid retention, and peripheral neuropathy occurred in 15 patients. There were no reports of febrile neutropenia, nor were there any deaths. The authors concluded that the combination of docetaxel and carboplatin as first-line therapy in metastatic breast cancer patients was promising with well-tolerated toxicities. A fourth trial also with the same schedule determined the safety and efficacy of the combination in 25 women with MBC. An ORR of 56% (CR 24%, PR 32%) was reported. Grade 3/4 toxicities included neutropenia (24%), one case of febrile neutropenia that required hospitalization and two patients with diarrhea. Anemia noted in seven patients was deemed "mild" and there were no reported toxic deaths. The authors concluded combination docetaxel and carboplatin was safe and active as first-line therapy in patients with MBC.