Methotrexate plus Ara-C will be given during the even-numbered courses (2, 4, 6, and 8). You will receive methotrexate on Day 1 by vein over 24 hours. You will receive Ara-Con Days 2 and 3 of each cycle, which will be given by vein over 2 hours every 12 hours for a total of 4 doses each time. Your dose of Ara-C may be decreased depending on your age, kidney function, or certain side effects you may experience. You will receive citrovorum or leucovorin after the completion of methotrexate, which will help decrease the side effects (such as mouth sores and kidney damage) of methotrexate. You will also receive a growth factor (G-CSF) after the completion of all cycles of Hyper-CVAD and methotrexate plus cytarabine. You will receive G-CSF as in injection just under your skin every day until you have healthy recovery of your white blood cells, which will be determined by the study doctor.