The specific goals of this phase 1 dose finding study conducted in consecutively enrolled patients 15 years and older are to prospectively and longitudinally assess the safety and tolerability, including cognitive effects, of CBD at various doses between 5 mg/kg/day and 25 mg/kg/day with additional titration in some cases up to 50 mg/kg/day. In order to participate in the study, participants will need to fulfill the inclusion and exclusion criteria.