Melancholia is typically associated with increased disease severity and therefore one might expect a lower prevalence in an RCT that only involves outpatients and excludes participants with significant suicidality and comorbidity. Therefore the researchers have made the criteria for defining the presence of criterion A1 B1 B2 B3 and B5 as loose as possible. Should these definition encompass more than 45% of the sample then the researchers would consider this to be too broad as it is not consistent with previous research regarding the prevalence of melancholic depression that would be expected in the sample. In this scenario the definition will be changed such that a score of 3 is needed on HAMD-17 Q8, Q9, and Q17, and a score of 4 or more is needed on the MADRS Q8. Should this new definition still be inappropriately broad (>45% of sample) the researchers will utilize a third definition that also requires a score of 4 or more on HAMD-17 Q8, Q9, and Q17, a score of 6 or more on MADRS Q8, and a score of 2 on HAMD-17 Q18 (if the specifier indicates mood is worse in the am). Between these three definitions it is likely that there will be an appropriate prevalence under 45% of the sample. If the researchers encounter the opposite problem, such that the prevalence is less than 15%, the researchers will loosen the initial definition such that only 2 of criteria B1, B2, B3, B4, and B5 are needed. If the researchers are still unable to obtain a prevalence between 15 and 45%, or a prevalence in this range but there are empty cells in the Cox model, the researchers will unfortunately not be able to proceed with the corresponding portion of the analysis (Analysis C, D, and E, as described below).