This is a cluster RCT at up to 50 sites where randomization will occur in a 1:1 ratio at the site level (not at the individual patient level). Therefore, up to 25 sites will be randomized to the PRO-TECT intervention arm (patient-reporting of symptoms plus access to standardized symptom management guideline), and up to 25 sites will be randomized to the control arm (usual care delivery plus access to standardized symptom management guideline). Specifically: