The effectiveness of the screening program depends on the accuracy and acceptability of the method used for detecting a pathological condition. An ideal screening test should have high compliance, high sensitivity and specificity, to be minimally invasive and cost-efficient. Because of the limitations of existing colon cancer screening methods there is a growing need to find new diagnostic methods for precancerous lesions and one of them are the molecular biomarkers that will be valuable tools in our arsenal to a safer approach to healthy subjects who are at high risk for CRC.