- Resting heart rate (HR) at screening or check-in on Day -1 <50 bpm (beats per minute) following at least 10 minutes of rest from either vital signs or ECGs. If HR is <50 bpm, the HR should be repeated two more times and the median of the three HR values should be used to determine the subject's eligibility. If the median value is <50 bpm, the subject is excluded.