Despite clear clinical implications, incorporation of PGx testing has historically been challenging due to potential delay in initiation of therapy and uncertainty of clinical and economic benefits. However, in the past decades, clinically actionable gene-drug interactions, such as the polymorphisms discussed above, have been identified. Additionally, the availability of high-quality genotyping in a timely manner with lower costs makes PGx testing feasible. Pilot studies implementing PGx testing have been conducted at academic centers.10,13-15 Though the knowledge gained from those studies enhanced their ability to implement PGx testing, pilot studies implementing PGx testing in a community-based health care setting in oncology treatment have not been conducted, to the best of our knowledge. Therefore, our pilot study would evaluate the feasibility of implementing PGx testing in routine oncology treatment at a community-based health care center. CRC is a common cancer and the drugs used in treating CRC are affected by PGx. Thus, CRC represents an ideal situation to evaluate the feasibility of routine preemptive PGx testing. While this study represents an initial pilot feasibility study, our ultimate goal is to evaluate the benefits of PGx in the community setting in regards to reduction of toxicity, improved cancer outcomes, and cost savings.