Chlorpromazine is rapidly absorbed and widely distributed in the body. Plasma half-life is approximately 30 hours and the elimination of metabolites may be prolonged. It is metabolized in the liver and excreted in the urine and bile. Whilst plasma concentration of chlorpromazine itself rapidly declines, excretion of chlorpromazine metabolites is very slow. Therefore, 10 mg chlorpromazine (Largactil®, Sanofi Aventis France) for i.v. infusion will be taken from Largactil® 25 mg/5ml ampoules for i.v. infusion (Largactil®, Sanofi Aventis France). Each ampoule of 25 mg/5ml will be used for only one volunteer.