Statistical Analysis: Demographics will be reported as aggregate means; if a larger than anticipated sample size is achieved we will also perform sub-analysis of individual groups (i.e., trauma vs. general surgical patients vs. neurovascular patients, etc). End points will be reported in means with a 95% confidence interval and will undergo standard significance testing (using α and β that are 0.05 and 0.20, respectively.) Continued Inclusion: Each patient will be assessed on a daily basis by a surgical critical care attending, resident, and pharmacist to determine appropriateness of his/her sedation regimen. If a patient continues to require significant additional sedative or narcotic outside the pre-established protocol, the patient may be withdrawn from the study and switched to a continuous infusion at the discretion of the attending physician in conjunction with the clinical pharmacist. In addition, a 24-hour on-call support for nurses and residents will be available to provide optimal, intermittent doses. At any time the attending critical care physician may remove a patient from the study at their discretion for any reason should it be required.