Ethical approval has been asked to clinical research ethics committee (CEIC) of all four pilot sites: ACCORD Medical Research Ethics Committee (AMREC) in Scotland and England, IRCCS Policlinico of Milan in Lombardy and CEIC of IDIAP Jordi Gol in Catalonia. Subjects will be informed of the objectives of the project. The confidentiality of the recruited subjects and their data will be ensured in accordance with the provision of European current legislation on personal data protection: 95/46/EC EU Directive (DPD) on Data Protection and the EU 2016/679 General Data Protection Regulation.