4. Total bilirubin </=1.5 x upper limit of normal (ULN). Patients with Gilbert's syndrome are excluded from this requirement. AST (SGOT)/ALT (SGPT) </=2.5 x ULN, (5 x ULN for patients with concurrent liver metastases). Serum creatinine </= within 1.5 x ULN. ANC >/= 1.0 x 10^9/L; PLT >/= 100 x 10^9/L.