Though several studies have been done to evaluate clinical response in lung cancer using alternating chemotherapies, none of these studies have evaluated clinical response with alternating Paclitaxel and Gemcitabine based treatment which are two of the most effective chemotherapy regimens in use currently. In studies of Platinum combinations that included one of these agents, results were better than those achieved with Platinum alone or combined with earlier generation agents such as Vindesine or Etoposide (12). Current evidence suggests that combinations of Paclitaxel or Gemcitabine with Cisplatin or Carboplatin are among the most active palliative treatments for advanced NSCLC. With combination of Cisplatin and Gemcitabine a response rate in phase II trials ranged from 30-54%, with median survival times of approximately 8-15 months and I year survival rates from 34-61% (13,14). Myelosuppression was the major toxicity, while Cisplatin associated nonhematologic gastrointestinal, renal and neurologic effects were also problematic. Attempts to reduce toxicity associated with the Cisplatin/ Gemcitabine regimen have included replacing Cisplatin with Carboplatin, a platinum analog possessing similar efficacy and hematologic effects, but lacking the non hematologic toxicity commonly experienced with Cisplatin therapy (15,16). Furthermore Carboplatin can be administered with no need for prehydration to avoid renal toxicity.