Phase IIa patients only: All of the six injections of LOAd703 will be done at BCM/BSLMC. During this phase of the study Before the first and the sixth of the six LOAd703 injections, a biopsy will be taken from the tumor (percutaneous needle biopsy or endoscopic procedure depending on the method of LOAd703 administration). Simultaneously to the LOAd703 treatments, and after the last LOAd703 injection, patients will continue to receive standard of care treatment.