FDRs and their spouses will undergo a comprehensive risk factor assessment including dietary, smoking, drinking and exercise habits. Data on past medical history, family history and treatment history will be collected. Anthropometric measurements (height, weight, waist circumference), blood pressure, heart rate and lipidemia markers will be recorded. Blood sample will be collected for biochemical measurements, which will include total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, Apoprotein-B and A1, lipoprotein (a), homocysteine, C-reactive protein and glucose. Blood will be stored for future genetic analysis. Risk for future events will be estimated according to Framingham and or procam risk score. The same procedure will be repeated at the beginning and at the end of the 2-year period.