2. Normal blood lipid profile (total cholesterol <5.2 mmol/L, LDL-cholesterol <3.4 mmol/L, HDL-cholesterol >0.9 mmol/L, triglycerides <1.7 mmol/L), plasma creatinine <1.5× upper limit of normal (ULN) where the normal range is 50-97 µmol/L, and glycated hemoglobin <6%; aspartate transaminase (AST) <2× ULN where the normal range is 10 - 32 U/L, and alanine transaminase (ALT) <2× ULN where the normal range is <25 U/L;