Patients with low performance status(Karnofsky score <80%) Past history of malignancy Stage investigations indicating unresectable advanced disease(T4 or M1a,M1b) Patients with any other serious underlying medical condition that would impair the ability of the patient to receive or comply with protocol treatment Patients medically unfit for surgical resection Patients with pulmonary reserve inadequate to undergo thoracotomy and extensive mediastinal lymphadenectomy.