For the MONITOR-IC study the investigators estimated to include 12.000 patients. This estimation is based on: 1) the initial ICU admissions in the academic hospital and the three other participating hospitals together (2,500 and 2,200 respectively per year), and 2) an estimated response rate of 60%, which is based on previous conducted ICU studies. In the control cohort, the investigators will include approximately 3000 patients during the next four years.