This is a single site study enrolling a total of 330 patients; 55 patients with presumed localized high risk prostate cancer scheduled to undergo prostatectomy or biopsy within 4 months of enrollment and 275 patients with suspected recurrent prostate cancer without definitive evidence of disease on conventional imaging. All patients will undergo a standard of care, clinical multiparametric endorectal coil MRI in the NCI Molecular Imaging Clinic within 4 months of the PET scan.