Selection of patients with either aggressive or low risk disease from the cohort from the 1000 patients expected at M18, 100 patients with highly aggressive disease will be selected. Selection will be made based on the criteria of high risk disease, mainly high grade PCa (Gleason score 8 or more) and/or pathological stage pT3. Each of these 100 patients will then be matched (center by center) with 1 patient with indolent disease and identical status for age (50 or less, 51-55, 56-60, 61-65, 66-70, 71-75, more than 75 years old) and BMI (normal, overweight, and obese). Criteria for indolent disease will include preoperative PSA < 10ng/ml, and Gleason score 6 or less (on the surgical specimen), and pT2 stage. If several indolent cases could be matched with 1 aggressive case, the one with the smaller tumor size will be preferred. Adipose tissue sampled from these 200 patients will be used.