Ejection fraction will be calculated from the formula: (end-diastolic volume end-systolic volume)/end diastolic volume. Functional improvement at 6 months will be calculated as percentage change of WMSI at 6 months compared to 7 day. Temporal changes in LV volumes will be calculated as the percentage changes at 6 months compared to baseline. Left ventricular remodelling will be considered as an increase in LV end-diastolic volume > 20% at 6 months compared to baseline (25-26). The core laboratory for the echocardiographic analysis will be the Catholic University of Rome.