- Other concurrent diseases/abnormalities: A subject must not have any clinically significant, uncontrolled condition or disease state that, in the opinion of the investigator, would put the safety of the subject at risk through study participation or would confound the interpretation of the efficacy results if the condition/disease exacerbated during the study. Additional excluded conditions/diseases may include (but not limited to): congestive heart failure, known aortic aneurysm, clinically significant coronary heart disease, clinically significant cardiac arrhythmia, stroke within 3 months of Visit 1 (Screening and Run-in Visit), uncontrolled hypertension (two or more measurements with systolic blood pressure [BP] >160 millimeter mercury [mmHg], or diastolic BP >100 mmHg), Recent or poorly controlled peptic ulcer, Haematologic, hepatic, or renal disease, Immunologic compromise, Current malignancy(History of malignancy is acceptable only if subject has been in remission for one year before Visit 1 (Screening and Run-in Visit) (remission = no current evidence of malignancy and no treatment for the malignancy in the 12 months before Visit 1 [Screening and Run-in Visit]), Tuberculosis (current or untreated) (subjects with a history of tuberculosis infection who have completed an appropriate course of anti-tuberculous treatment may be suitable for study entry provided that there is no clinical suspicion of active or recurrent disease), Cushing's disease, Addison's disease, uncontrolled diabetes mellitus, uncontrolled thyroid disorder and recent history of drug or alcohol abuse.