- Severe hemophilia A, defined as less than (<) 1 international units per deciliter (IU/dL) (<1 percent [%]) endogenous FVIII at screening as determined by the one-stage clotting assay from the central laboratory. If the initial screening result is greater than or equal to (>=) 1%, then a repeat endogenous FVIII activity level will be performed using the using the one stage clotting assay from the central laboratory. If the repeated result is < 1 IU/dL (<1%), then the participant will meet this inclusion requirement