The total participants that will get screened has been changed (from the original AICR grant) and revised in the budget from 300 to 400 participants. The investigators made this revision because the investigators decided that loss to follow-up may be higher than the originally estimated 10%. The investigators then estimated that loss to follow-up may actually be closer to 20%. This proportional difference was calculated from the investigators' original estimate of 52 to 64 (which is about 24% increase in participants) and was revised also to increase the amount of participants that the investigators will screen from the original 300 to an estimated 372 (determined proportionally with a 24% increase). The investigators went ahead and assumed that the upper limit may include 400 participants so that the investigators can end up with 64 participants in the supplementation trial.