• Justification of the Study: It is important to determine if empiric deworming can be beneficial for the millions of pre-HAART HIV-1 positive individuals living in helminth endemic areas. Documenting the potential effects of such an intervention on markers of disease progression will serve to inform practical approaches for cost-effective interventions in resource limited settings. Interval anti-helminth therapy may be a feasible option in many areas of the world to delay immunosuppression, to enhance the response to antiretroviral therapy or to reduce infectiousness in HIV-1 infected individuals. In addition, as patients progress to HAART, it is important to determine the ideal timing for helminth eradication.