The researchers did not know what proportion of patients would be prepared to pass on the questionnaire or what response rate would be received from confidants. Rees in her work with daughters of women with breast cancer found that 93% of patients passed the questionnaires on and 77% of daughters responded. If we got an overall 60% response (ie 240 before and after questionnaires) this would give us 80% power to find a difference between 40% and 23% who had improved anxiety between (eg) 120 in personalised group vs 120 in general group. The confidant population would be less than the patient population. Patients will not be excluded if there is no corresponding 'confidant'.