If greater than or equal to 40% of subjects treated develop a greater than or equal to Grade 3 toxicity thought to be related to the study drugs; or If greater than or equal to 10% of subjects experience an unexpected ipilimumab-related greater than or equal to Grade 3 toxicity that cannot be alleviated or controlled by appropriate care and/or steroid and/or infliximab therapy within 14 days of the initiation of such therapy.