In total 40 mls of saliva, 30 mls blood and three 24h urine samples will be collected. Labelling of saliva, blood and urine samples will be anonymized. Saliva and blood samples will be centrifuged. The separated serum/plasma and extracted saliva will be kept frozen at -80oC until analysed in one batch (to minimise analytical variation). 24h urine samples will have their volume measured and an aliquot will be kept frozen at -80oC until analysed in one batch.