1. Meet study's subjects number. This is the main problem we face. Although we follow regularly around 1900 SLE patients, finding 106 peri/postmenopausal women who would accept to participate in the study after reviewing inclusion/exclusion criteria remains a hard number to reach. However, every year about 200 new SLE patients come to our Institute. We expect to meet the necessary number to conduct the study. If we noticed we had a low number, we will invite lupus patients from other institutions to participate.