The treatment of neovascular age-related macular degeneration (AMD) with anti-vascular endothelial growth therapy (ranibizumab and bevacizumab, Genentech, South San Francisco, CA) requires repetitive and often long-term intraocular injections and has raised concern about increasing rates of endophthalmitis. Endophthalmitis remains one of the most feared complications in ophthalmology and despite early detection and intervention can result in substantial morbidity. Recent multicenter clinical trials of anti-vascular endothelial growth therapy have reported endophthalmitis rates of 1.0% to 1.9% per patient treated (during a 6 month to 2 year period of follow-up). Consequently, topical antibiotics are routinely prescribed after intraocular injections, although no published study to date has proven their efficacy in preventing post-injection endophthalmitis. 1,2