RIC treatment could prove to be an attractive non-pharmacological non-surgical treatment option for a large population of diabetes patients. The trial will result in 5 publications on the efficacy of RIC on neuronal function, on vascular function, on lipidomic profiles, on marker of inflammation and oxidative stress (Tentative titles of articles are listed in Appendix 3) and patient empowerment and quality of life. The study is recommended by an independent Professor of Cardiology (Appendix 4).