The overall goals of this project are to 1) provide control (ambulatory) data for a subsequent grant proposal in which losartan will be tested for its ability to reduce loss of muscle mass and function during simulated hospitalization (SH) in older individuals, 2) determine the effect of losartan on basal and meal-stimulated muscle protein synthesis, in older individuals, and 3) determine the effect of N-acetylcysteine (NAC) on basal and meal-stimulated muscle protein synthesis in older individuals.