Propofol (2,6 di-isopropylphenol) is available as an emulsion of 1 % propofol in 10% soyabean oil, 2% glycerol and 1.2% egg phosphatide. Doses up to 2.5mg / kg are used for induction of anesthesia and doses up to 200ug / kg /min are used for sedation purposes.33 It remains uncertain how propofol might exert its action in relieving headache. Propofol is known to stimulate gamma - aminobutyric acid- A (GABA-A) receptors by enhancing channel opening34 It has been shown that other GABA ergic drugs including sodium valproate, gabapentin and topiramate have a place in the treatment of migraine and it is speculated that propofol might be work in a similar way.35 Nonetheless, it is known that propofol has other important pharmacological activity including N-methyl-d-aspartate receptor antagonism, sympathetic inhibition, stimulation of nitric oxide production, calcium channel inhibition and modulation of prostaglandin E2 hyperalgesia.36-39 We propose that it is premature to speculate on the action of propofol in headache without clear evidence of efficacy.