Females of non child-bearing potential defined as: >1 year postmenopausal, which can be >1 year of spontaneous amenorrhea or >1 year post surgical bilateral oophorectomy. Use follicle stimulating hormone [FSH] levels >40mIU/mL to confirm surgical postmenopausal status, where bilateral oophorectomy status is uncertain. Females of child-bearing potential must have a negative urine bhCG pregnancy test at the Screening visit and agree to practice acceptable highly effective methods of birth control throughout the duration of the study. Highly effective birth control methods include those preventative measures taken to avoid pregnancy that have a failure rate of less than 1% per year.