11. Patient has known clinically significant cardiac disease or impaired cardiac function, such as: oCongestive heart failure requiring treatment (New York Heart Association grade >/= 2), LVEF < 50% as determined by MUGA scan or ECHO oHistory or current evidence of clinically significant cardiac arrhythmias, atrial fibrillation, and/or conduction abnormality, e.g., congenital long QT syndrome, high-grade/complete arteriovenous blockage oAcute coronary syndromes (including myocardial infarction, unstable angina, coronary artery bypass graft, coronary angioplasty, or stenting) < 3 months prior to screening