- Subjects of reproductive potential with partners who are women of childbearing potential, will be instructed to, and must be willing to practice a highly effective method of birth control for the duration of the study and continuing 90 days after discontinuing treatment with the investigational product. Highly effective methods of birth control include sexual abstinence, vasectomy or a condom with spermicide (men) in combination with barrier methods, oral, injected, or implanted hormonal birth control methods, or placement of an intrauterine device or intrauterine system (for female partner).