200 patients with AMI, WMSI > 1.3 and MPI > 0.55 (100 patients in the irbesartan group and 100 in the usual care group). The patients will be included in the analysis of the primary endpoint. Further, approximately 100 patients with AMI, WMSI <= 1.3 and MPI > 0.55 treated with an ACE-inhibitor would be part of the secondary endpoints.