Results from observational studies such as WAVE and AURA, which investigated wAMD patients treated with Lucentis (ranibizumab) in a real life setting in western countries, suggest that these patients are not treated according to a continuous treatment pattern and are also undertreated resulting in suboptimal treatment effects. In the WAVE Study (n=2587) patients received 4.3 injections during the first treatment year and the visual acuity returned to the baseline visual acuity at the end of the year. In the AURA study (n=420), German cohort, patients received 4.3 injections in the first year and only 2.1 injections during the second year. The visual acuity declined during year 1 to -1.4 letters and further declined to -2.4 letters during year 2 compared to baseline. In the AURA study (n =365), Italian cohort, patients received 3.9 injections in the first year and only 1.4 injections during the second year. The visual acuity declined during year 1 to 0 letters and further declined to -2.9 letters during year 2 compared to baseline .