This study is to be a double blind crossover comparison study in patients during a migraine headache attack, with assessments at one and two hours after treatment. Patients with an IHS diagnosis of migraine with or without aura may be included. The patients will complete a questionnaire regarding the nature of their migraine attacks, including their impression of cognitive impairment if any. Historically associated symptoms will be listed. Menstrual associated migraine history will be assessed. 30 patients will be randomized to Treximet or placebo in a 1:1 manner for the first treatment and in reverse order for treatment on the second migraine attack. In this manner, each patient will be his or her own control. 60 migraine headaches will be treated in this study. Also, it has been previously discussed that after 3 practice sessions with the MEWT, further administration of the MEWT does not produce bias by a practice effect as the ANAM has been shown not to produce bias by a practice effect.10 Therefore, patients will have 3 practice sessions in the clinic before taking the baseline MEWT.