Squamous cell carcinoma (SCC) of the lower extremity is a distinct subset of cutaneous squamous cell carcinomas which tend to occur multiply in elderly women. In contrast, the majority of cutaneous SCCs occur on the head and neck, and in men more than women. Histopathological studies of lower extremity SCCs revealed that they tend to be well differentiated and have low incidence of perineural and lymphovascular invasion. SCCs of the lower extremity are also less prone to metastasis. Surgical excision has been the mainstay in the treatment of SCC, including lower extremity SCC. However, the lower extremity, as a site, is prone poor wound healing and postoperative complications such as infections. Furthermore, a phenomenon called eruptive postoperative SCC can occur, in which cytokines released during wound healing trigger secondary tumor formation in genetically predisposed cells surrounding the original SCC. Given that lower extremity SCCs are less aggressive but more prone to surgical complications when excised, the investigators believe these types of lesions may be good candidates for non-surgical treatment.