If the Expansion Cohort 2.2 dose is not tolerated, Expansion Cohort 2.1 will be expanded to 6 subjects, unless this has already occurred. If more than 1 subject of the 6 experiences a DLT, the Expansion Cohort 2.1 dose of PV-10 plus sorafenib will judged to be intolerable. Otherwise, the Expansion Cohort 2.1 dose will be the MTD for the study.