Breast ductal lavage is an important new procedure that can be used to help determine a woman's risk for breast cancer. It is an attractive diagnostic method since it is associated with very little discomfort. At present, it is only used in certain women who are thought to be at very high-risk for breast cancer. During the ductal lavage procedure, the fluid-producing ducts must first be identified. This is done by first freeing the ducts at the nipple surface of keratin plugs, and a woman then uses massage to produce fluid. This fluid, called nipple aspirate fluid (NAF), is what bathes the breast ducts and will be collected for analysis in this proposed project. Once the ducts that produce NAF are identified, the physician then lavages the duct. The lavage fluid washes out breast cells that can then be evaluated by a pathologist to determine whether or not they are normal. The entire procedure is done using anesthetic at the nipple surface initially and in the lavage fluid to minimize any discomfort, and levels of discomfort is generally less than that with a mammogram.