RIC has been shown to have beneficial effects by attenuating platelet activation and aggregation, improving endothelial function , improvement of microcirculation , down-regulation of neutrophil function , down-regulation of inflammatory gene expression , improving mitochondrial function and inducing changes in serum lipid composition One of few long-term RIC treatment studies has shown that twice daily RIC treatment for 300 days is feasible. The study showed that RIC could reduce the recurrence of stroke