It becomes necessary to identify simpler, less invasive and more affordable methods of finding precancerous lesions for sporadic type of CRC. One such method is the use of potential biomarkers (i.e. objectively measurable indicators of a normal or abnormal process) using a sample of blood (plasma) of the person in order to find mutations or epigenetic changes in known genes that have been implicated to participate in the process of carcinogenesis of CRC.