3. Recruitment & informed consent procedures A letter of invitation regarding this study will be mailed to the potentially eligible patients a week before their appointment date along with the consent document. On the day of the clinical visit, the research assistant will explain the study to the eligible subject and acquire signed consent from the participants. 400 subjects will be recruited. These patients will be monitored once every six months (the current standard of care). When clinically warranted due to signs of disease progression or at the 2-year follow-up mark, two 5-mm punch biopsies will be performed on lesion areas with different severity (as determined by imaging technologies). Two-year comparative biopsy at a stable lesion is current standard of care.