Levetiractam Levetiracetam was approved by the FDA in 1999 for the treatment of epilepsy. Levetiracetam was shown to be an effective pharmacologic treatment for refractory partial seizures in a number of large multicenter clinical trials (French, et al., 2001; Cramer et al., 2003; Morrell et al., 2003). The pharmacokinetic profile of levetiracetam has particular advantages over other anti-epileptic drugs. Pharmacologic advantages include low protein binding, renal clearance, and an absence of drug interactions (Perucca and Johannessen, 2003.).