In breast cancer patients, it has been shown that changes in cytokines levels, Including IL-1β and IL-6, also correspond with the response of the malignant tissue to treatment. In this case, a good clinical response to therapy has been associated with decreases in IL-1β and IL-6 levels, versus increases in their levels which have been associated with the progression of the disease. Furthermore, tumor markers such as the cytokeratin TPS, have been shown to be sensitive in assessing the tumor's response to therapy and the patient's prognosis.