To test our hypothesis, we proposed the epigenomic-modified targets as DNA methylation of the gene encoding metabolism enzymes and receptors of antihypertensive drugs. Target-1 is CYP2D6, involved in quarter of total clinical used drug metabolism，40% of them are used to treat cardiovascular disease. Other important CYP 450 enzymes targets involved in cardiovascular drug metabolism are CYP3A family, CYP2C family[8].