3. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) < 3× the upper limit of normal (ULN) and total bilirubin < 2.5×ULN; values up to 5×ULN for ALT, AST, and/or total bilirubin are acceptable if the elevation is considered due to EBV-associated disease involvement of the liver