Exclusion criteria A) Signs or symptoms of severe malaria including the following symptoms Prostration. Impaired consciousness. Respiratory distress. Repeated generalised convulsions (three or more per 24 hours or 2 witnessed seizures in 24 hours). Circulatory collapse. Abnormal bleeding. Jaundice. Haemoglobinuria (dark red/black urine). Severe anaemia (Haemoglobin <5g/dl). Hyperparasitaemia (>200.000/ µl asexual forms) B) Presence of general danger signs in children under 5 including the following Prostration. Respiratory distress. Haemoglobin <5g/dl. Two or more convulsions within 24 hours. Persistent vomiting C) Presence of severe malnutrition. D) Any evidence of chronic disease or acute infection other than malaria. E) Regular medication which may interfere with antimalarial pharmacokinetics. F) History of hypersensitivity reactions or contraindications to AL, DP or quinine.