Perez et al studied docetaxel (75 mg/m2 IV over 1 hour) followed by carboplatin (AUC 6 IV over 30 minutes) as first-line chemotherapy in 53 women with MBC. Patients received a median of 6 cycles. An overall response rate (ORR) of 60% (complete response [CR] 6%, partial response [PR] 54%) was noted. Grade 3/4 toxicities included anemia (11%), neutropenia (94%), thrombocytopenia (17%), febrile neutropenia (15%), leukopenia (15%), fatigue (21%), infection (11%), diarrhea (11%), hypersensitivity (8%), neurosensory (4%), and neuromotor (4%). A total of 26 patients received granulocyte colony-stimulating factor (G-CSF) and/or erythropoietin support. The authors concluded that although myelosuppression was noted, docetaxel and carboplatin were an active treatment regimen for first-line therapy in MBC and prophylactic hematopoietic growth factor support is recommended.