Radiation Therapy Data for the use of radiation therapy (RT) alone in the setting of unresectable disease is sparse. In a report from Johns Hopkins, a total of 23 patients were treated with a surgical procedure followed by RT.14 Complete resection was accomplished in 14 of these patients and palliative stenting for 9. Postoperative RT doses ranging from 45-63 Gy delivered by external beam radiation therapy (EBRT) followed by brachytherapy boost or EBRT with cone down boost. RT had no effect on overall survival of patients who had undergone complete resection or on patients who were being treated with palliative intent. Of note, none of the patients in this study were treated with concurrent chemotherapy. The subgroup of patients who were stented and then treated with palliative RT applies to our current investigational study group, and in this subset of patients there was no survival benefit for RT alone.