Separate repeated measures analysis of variance (RMANOVA) models using a mixed models approach will be used to compare the two treatment arms with respect to their vaginal discharge, POP-Q staging , PFDI, and PFIQ trajectories from baseline to 24 weeks. Each model will include the main effects of treatment arm (Estrace® or placebo) and time (0, 12, and 24 weeks), as well as the treatment x time interaction. If an interaction between group and time is not found to be statistically significant, only the main effects of treatment group and time will be analyzed. For all analyses, the standard assumptions of Gaussian residuals and quality of variance will be tested. If the standard assumptions are not met, a transformation will be performed.