Investigators will use descriptive statistic tools to describe groups (mean, standard deviation and standard error or median and interquartile range). For group comparisons, unpaired T test, Mann Whitney or Fisher's test will be used. ANOVA, Kruskal Wallis and Chi Square test will be performed for to compare unmatched groups; to quantify association between two variables Pearson and Spearman correlation test will be used. Simple or multiple regressions will be considered to predict value from variables. P value <0.05 will be deemed significant. A sample from the general population was calculated considering the adult population between 21-70 years old in Ecuador.