Therapeutic phlebotomy is well-established for treatment of iron overload associated with hereditary hemochromatosis (9) and beta thalassemia after HSCT (10). Phlebotomy has also been studied in survivors of acute leukemia with iron overload. Franchini et al. showed that phlebotomy was feasible and well-tolerated in this population and resulted in normalization of ferritin and transferrin saturation (11). This study demonstrated feasibility of phlebotomy but the effect of iron reduction on end-organ function was not addressed.