Since our study involves treatment of patients with acute neurological impairment, they are not competent to give informed consent. We will therefore seek proxy consent from the patient's family or next-of-kin or legally authorized representative (LAR). If an LAR is subsequently located that objects to the study, the process will be halted and the patient's participation will be terminated. Only the IOCs, or the study coordinator, will be permitted to approach family members to request consent.