Total 13 sites provided both CCTA images and granular clinical data for core laboratory adjudication. Several countries in Asia, Europe, and North America currently represent this multinational effort. The population for ICONIC comprises a representative sample of individuals with suspected CAD who have undergone CCTA by ≥64-detector rows. In this regard, ICONIC recruited adult individuals who were deemed suitable for study enrollment according to the inclusion and exclusion criteria set out. Patients with a prior history of CAD before CCTA scanning were excluded from enrollment. Death occurring on the same day as an ACS, or after an ACS, met the inclusion criteria. Likewise, interval revascularization between CCTA and ACS did not warrant exclusion from ICONIC.