A potential contributor to deep dyspareunia in women with endometriosis that is largely under-researched is the concept of central sensitization. Central sensitization is an amplification of nociceptive signaling that may result from prolonged pain causing sensitization of the dorsal horn neurons, which results in hyperalgesia (increased response to pain) and allodynia (response to pain when there normally would not be). A recent study, comparing cross-sectional data from suspected or surgically diagnosed endometriosis patients, suggested that bladder and pelvic floor tenderness may be markers of central sensitization. However, the linkage between the indirect markers of central sensitization and the presence of central sensitization requires confirmation. This link can be assessed through validated quantitative sensory testing (QST). Likewise, the association between central sensitization and deep dyspareunia may also be confirmed through QST. QST is an objective measurement tool to determine the presence and/or degree of sensory disturbances, by detecting the alterations in nociceptive pathways. For example, a low pain-pressure threshold (i.e., increased pain sensation) at healthy unaffected areas, as measured by QST, indicates central sensitization.