Each screening center will invite women, will send the box with self sampling device, receive the self sampling device from the invited women, register them in the database, send the samples to ISPO. ISPO L.R.P.O (Regional Oncological Prevention Laboratory) will perform hr-HPV testing and send the results to each screening center. Each screening center will receive the hr-HPV results from ISPO and send them to the woman. In case of HPV positive results the local screening center will contact the woman by phone for colposcopic assessment, perform colposcopy and every further follow-up visits, record the results and questionnaires data in the data base and participate in evaluation of the results.