- Elevation of a serologic biomarker of inflammation (CRP), of myocyte injury (Troponin, Caspases), heart failure (BNP), and extracellular matrix remodeling (PICP, CITP, PICP/CITP ratio, MMPs and MMPs/TIMP ratio).Changes in regional myocardial function and elevation of serologic markers may predict freedom from LV dysfunction defined as EF ≥55% at 1 year.