- Radiotherapy that involves the lung (V20 exceeding 30% lung volume) or mean heart dose of >20Gy within 3 months prior to lymphodepleting chemotherapy; for a lesser dose of radiation exposure to lung/mediastinum than stated, administered within 4 weeks prior to lymphodepletion. Electron beam radiotherapy to superficial structures in the chest is permitted. Radiation to other vital organs (e.g., liver, spleen, GI tract) within 2 weeks prior to lymphodepletion. Radiotherapy to the pelvis within 4 weeks, NOTE: there is no washout period for palliative radiation to non-target organs other than the lung and mediastinum. If radiation was to an intended target lesion within 3 months of baseline imaging studies, and the lesion is progressing within this time frame it may be considered as a target lesion after review and discussion with the Sponsor.