Praziquantel is a heterocyclic prazino-isoquinoline derivative with significant activity against both cestodes and trematodes. Praziquantel is highly effective against schistosomes in humans and there have been no confirmed cases of resistance reported. Praziquantel is well tolerated and severe adverse reactions are rare. There have been rare cases of increased intracranial pressure during treatment in patients with neurocysticercosis. This is not anticipated to be an issue in Kenya due to the low level of pork consumption in this population and the rarity of Taenia solium. In the study described above, we screened over 1600 individuals for helminths and documented no cases of Taenia solium (Walson J, unpublished data). Praziquantel is contraindicated in pregnancy and all female patients will undergo urine beta-HCG testing prior to administration. Pregnant or breast feeding women will not receive praziquantel.