All 18 T2D participant will undergo randomization at baseline to two 40 days treatment periods, either starting with LIR treatment, and then after 2 weeks of wash-out, will crossover to second treatment period of 40 days with PLA, or vice-versa, starting the first period with PLA during 40 days and then crossover to 40 days with LIR. The treatment with LIR and PLA will be up-titrated progressively from 0.1ml to 0.3ml to avoid the secondary effects of LIR.