FSR Extensive preliminary data are available from our research team regarding changes in protein synthesis. The primary statistical approach is ANOVA and the study design described above for Aim 1. Preliminary data from the PI's lab were available for the outcome of FSR. The mean increase in FSR with vasodilator (SNP) infusion was 0.02, with a SD of the change score of 0.026. Based on a previous animal study which found that antioxidant administration restored amino acid stimulation of muscle protein synthesis, along with the fact that losartan and NAC may exert non-perfusion related effects that could augment anabolic responses, the investigators estimate a change of 0.07 with each treatment, with a SD of the change score of 0.026. Power calculations from the SAS procedure GLMPOWER indicate with N=8 per group (24 total) will provide >99% power to detect the treatment effects, using a 2-sided alpha level of significance of 0.05.