ICG, when injected intravenously, rapidly binds to plasma proteins and is exclusively excreted into bile by the liver. It is known to be well tolerated but there have been reported cases of urticaria and anaphylaxis. Risk of anaphylaxis is 1 in 10,000 and if occurs can be treated using a standard protocol. ICG contains sodium iodide and therefore should be avoided in patients with known allergy to iodides.