Pain, as an ancient enemy to human kind, was one of the most mystical phenomena within our body. For centuries, people search the magic wand to solve this issue and reach the heaven destination. However, like our original sin commit by Adam and Eve, the shadow of pain always surround and even rebel our body and spirit. Even more, pain traps our soul and body not only for the acute stage induced by noxious stimulation but also change our mind and body whenever chronic period start even the stimulation disappears. Chronic pain so far has become one of the greatest health issues for modern people. Chronic pain affects millions of people and the treatment options are quite limited and not effective everyone[1]. On the other way, why and how people develop chronic pain, especially when there is no further painful stimulation, remain to be investigated.