We have recently demonstrated that in patients clinically suspected of venous thromboembolism, Pre-test Clinical Probability (PCP), D-dimer and the use of LMWH can be safely used for delaying diagnostic tests for up 72 hours (Siragusa S et al. Arch Intern Med 2004;164:2477). Our paper was mainly focused to patients suspected of Deep Vein Thrombosis (about 80% of the patients’ cohort) which are considered a category at lower risk for complications than PE patients.