However, this does not necessarily mean that FDG is a poor tracer for imaging PCa. In fact, it may be a very useful one, if considering several factors not taken into account in the past. The traditional acquisition time point one hour after administration of tracer may not be the ideal one. This time point is entirely arbitrary. The increase in FDG accumulation seems to take place for several hours after administration in malignant tissue, whereas FDG accumulation in normal or inflamed tissue may reach a maximal uptake at an earlier time point . Thus, late imaging may result in increased FDG accumulation and decreased blood and urine background and, therefore, a much better signal-to-noise ratio and subsequently better results. A recent review on the use of dual-point acquisition demonstrated an increased specificity and sensitivity for the detection of several malignancies . The use of dual time point FDG-PET/CT in staging of PCa has not been investigated.