- Use (within the past 30 days) of: Illegal drugs (or if the urine drug screen is positive); Experimental (investigational) drugs; Psychiatric medications including antidepressants, anti-psychotics or any other medications that are known to affect smoking cessation (e.g. clonidine); Smokeless tobacco (chewing tobacco, snuff), e-cigarettes, pipes, nicotine replacement therapy, or other smoking cessation treatment; E-cigarettes;