Stage-2: follow up was extended for 3 years to investigate the association of genetic risk factors as well as pharmacoepigenomic changes in antihypertensive drug-related metabolism enzymes and drug receptors with clinical phenotypes, including primary clinical endpoints, total death, cardiovascular death, acute myocardial infarction, stroke; secondary clinical events: rate of resistant hypertension, target organ damage, left ventricular hypertrophy, chronic kidney disease.Financial funding was supported by Qingdao HuangHai pharmaceutical.co., LTD.