Hypothesis 1 will be tested with the contrast indicated as per the Aim 1 Prediction in the table above. This is analogous to a directional test of the Group-by-Time-by-Task interaction. Hypothesis 2A will be tested as per the Aim 2 Prediction in the table. We predict that ARI treatment supports greater task-related Modafinil effects on LC activity, vs. RIS treatment. Hypothesis 2B will be tested across all patients by correlating α2 load (by antipsychotics) with mean task-related LC betas from the Treatment X Task Condition contrast. Significance for all analyses is set at p<.05, FDR-corrected, or using the LC as SVC, as appropriate. Accuracy and RT cost will be tested by ANOVA.