With regards to its use in the neoadjuvant treatment, this combination was studied in 57 patients with stage II/III breast cancer (10). Docetaxel (75 mg/m2) and carboplatin (AUC 6) were given on day 1 with pegfilgrastim (6 mg subcutaneously) on day 2. This regimen was repeated in a dose-dense manner every 2 weeks for 4 cycles. Fifty-one patients (89%) had breast-conserving surgery within 6 weeks. Among all 57 patients, a pathological complete response (pCR) of 16% was reported. Four out of 9 patients with triple negative tumors had pCR (44%). Thrombocytopenia was the only grade 4 toxicity reported. Grade 3 toxicities in addition to thrombocytopenia consisted of anemia, fatigue, diarrhea, nausea, and hypokalemia. The authors concluded the combination of docetaxel, carboplatin, and pegfilgrastim was feasible and tolerable in all patients.