Recently, a study into the effects of an intervention developed by 'The Iceman' Wim Hof revealed that it is possible to voluntarily attenuate the pro-inflammatory response during experimental human endotoxemia (a standardized, controlled, and reproducible model of systemic inflammation elicited by administration of lipopolysaccharide (LPS) in healthy volunteers). The intervention developed by Hof consists of several elements, namely meditation, exposure to cold and breathing techniques. Subjects trained in this intervention exhibited profound increases in plasma adrenaline levels, a rapid increase of the anti-inflammatory cytokine IL-10, and subsequent attenuation of the pro-inflammatory response (e.g. plasma levels of TNF-α, IL-6, and IL-8) during experimental human endotoxemia. This intervention could therefore represent a treatment modality that would empower RA patients to exert self-control over their disease.