- Is in good health (ASA Class I) based on medical history and clinically acceptable results on the following assessments: physical examination, vital signs, 12 lead ECG, clinical chemistry, hematology/coagulation, and urinalysis. Seated systolic BP must be > 90 mmHg and ≤ 140 mmHg and seated diastolic BP must be > 50 mmHg and ≤ 90 mmHg at Screening and Baseline