Future Studies Many potential avenues may be explored following these experiments. If our hypothesis is correct, and findings that losartan is capable of significantly improving nutritive flow to skeletal muscle and capacity for net muscle protein anabolism, the investigators will pursue longer-term outcome studies with this novel vasodilator, perhaps during a simulated hospitalization period. Potential future studies include looking further into the amino acid signaling pathways and determining if suppression of TGF-β blocks transcriptional upregulation of the ubiquitin E3 ligases. However, if findings that losartan does not promote nutritive flow to skeletal muscle or the capacity for net muscle protein anabolism, then the investigators will further examine the mechanisms behind the apparent lack in nutritive flow mediated stimulation of muscle protein synthesis (e.g., studies with amino acids to determine where the defect lies in the intracellular signaling pathway). If losartan or NAC can successfully improve nutritive flow to skeletal muscle and capacity for net muscle protein anabolism in healthy older subjects, the investigators will pursue additional outcome studies during and following inactivity, like common elective surgeries such as hip and knee replacement.