Submission of diagnostic tumor samples and blood samples for FB-10 correlative science studies will be a study requirement for all patients. Blood samples will be collected at baseline, at Cycle 2, Day 1, and at progression. Blood samples for pharmacokinetic (PK) determination will be collected at Phase 1 sites from consenting patients at various time points during the first 24 hours of study therapy (Cycle 1, Days 1 and 2).