Cilostazol, an FDA approved drug for the treatment of intermittent claudication, is a class IIIa phosphodiesterase inhibitor. Its systemic effects in humans include vasodilation, decrease in platelet aggregation, reduction in triglyceride levels, and increase in HDL cholesterol levels (4). Human clinical trials did not address fertility and pregnancy rates; however, manufacturer product labeling reports that no fertility effects occurred in rats. Most recently, however, two animal in vivo studies examining pregnancy rates of mice treated with Cilostazol were conducted (1,10). In both of these studies, mice treated with Cilostazol were shown to be completely infertile at follow up; however, once the drug was discontinued, all mice that were unable to conceive during treatment with cilostazol were subsequently able to have pregnancies of normal litter sizes. It is important to mention that in the study by Albarzanchi, mice received PO cilostazol at a dose of 7.5 or 15 mg PO for three days (1). In the study by Li conducted in China, the maxium dose was higher (300mg/kg) (10). Pregnancy outcomes for both studies were the same.