- Serum creatinine ≤ 1.5 × the ULN (106 µmol/L) or creatinine clearance ≥ 50 mL/min on the basis of the Cockroft−Gault glomerular filtration rate estimation: [(140−age) × (weight in kg × (0.85 if female)]/[72 × (serum creatinine in mg/dL)]