At 6 and 12 month follow up appointments, subjects will undergo a second round of procedure/s with either CE or IC with or without MRE. The following assessments will also take place at the 6 and 12 month follow up appointments: Laboratory tests, Pregnancy test, Concomitant medications, Patient satisfaction questionnaire, Adverse events. In addition at the 12 month follow up visit the Quality of Life Questionnaire will be completed as well.