Validation and development of these biomarkers into biomarker panels and rapid, POC, IVD for early differentiation of pathogen in sepsis and CAP is intended, but is beyond the scope of the present proposal. A product line extension of the SS IVD is envisaged. Like the test for early diagnosis of SS, the IVD(s) for early differentiation of CAP and sepsis pathogens will be oligoplex assay(s) performed on single blood sample(s) using immunoassays or other analyte assays.