Importantly, in this trial, the treatment interventions will reinforce both cocaine and opioid abstinence. Many opioid-dependent individuals also abuse, or are dependent upon, cocaine. Additionally, opioid-dependent individuals who also use cocaine represent a population of substance abusers at particularly high-risk for HIV infection from both their high level of risky drug-injection and sexual risk behavior. Nevertheless, polydrug abuse in this population has been rarely addressed. By targeting both drugs, our understanding of effective ways to address polydrug abuse will be increased.