We retrospectively reviewed the clinical, radiological and biological data of 28 consecutive patients with a diagnosis of CAA-ri between 2004 and 2016, in 6 different neurological centers from Occitanie in the south of France (Montpellier, Toulouse, Nimes, Narbonne, Bezier, Perpignan). Inclusion criteria were the following: 1) pathological diagnosis assessed by both CNS Aß vascular deposition and transmural of perivascular inflammation or 2) a probable or possible CAA-ri according to the recently criteria proposed by Auriel et al. (Auriel, JAMA 2016). CAA diagnosis before onset was done retrospectively according to Boston Criteria (Knudsen, Neurology, 2001) (Smith, Cardiovascular disease and stroke, 2003).