For multi-parameter mapping, 3 multi-echo datasets will be acquired with T1-, PD-, and MT-weighting imposed by the choice of repetition time (TR) and flip angle (T1: 18.7 ms/20°; PD and MT: 23.7 ms/6°), and by applying an off-resonance Gaussian-shaped radio frequency (RF) pulse (4 ms duration, 220° nominal flip angle, 2 kHz frequency offset) prior to nonselective excitation, respectively. Alternating gradient echoes are acquired at 6 equidistant echo times (TE) between 2.2 ms and 14.7 ms for the T1- and MT-weighted acquisitions and at 8 equidistant TE between 2.2 ms and 19.7 ms for the PD-weighted acquisition. A high readout bandwidth (BW) = 425 Hz/pixel is used to minimize off-resonance artifacts. To speed up data acquisition, Generalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) imaging with an acceleration factor of two is applied in the phase-encoding (anterior-posterior) direction and 6/8 partial Fourier in the partition (left-right) direction. The total acquisition time for the 3 FLASH datasets is approximately 20 min. The rationale and detailed design criteria for the protocol were previously published. The multi-parameter mapping provides better sensitivity over the classically used T1-weighted imaging. The main advantage is that it allows quantitative assessment of changes in myelin content, tissue water and iron (transferrin, ferritin).