This study uses a computerized random method. According to preoperative use of different antimicrobial drug or treatment, all patients are randomly divided into three groups, namely levofloxacin group, nitrofurantoin group and control group.The levofloxacin group receives levofloxacin 0.5g, qd, po, the nitrofurantoin group was given oral nitrofurantoin 100mg, tid, po.to explore the better antibiotics types, medication timing and duration of treatment to prevent postoperative infection after minimally invasive upper tract lithotomy, so as to reduce the incidence of postoperative urinary tract infection or sepsis.