Material abuse nowadays become a serious public health issue, among these, abusing of opioids is the most serious one. It cause HIV infection rate hiking up, recent years in Taiwan, it impairing people health as well. The successive 2 year methadone substitutive abstaining program makes HIV infection rate remarkable decreasing which proven this public health program is successful in controlling HIV spreading. However, methadone substitutive abstaining program can reduce physically and psychologically dependent with opioids for the opioid abusers, collateral benefit is reducing related criminal behaviors and dangerous contagious behaviors, such as sharing the hyperdermic needle.