Lenalidomide On Days 1-21 of Cycles 1, 3, 5, and 7, you will take lenalidomide by mouth once a day. You should take lenalidomide at the same time each day. You should swallow the lenalidomide capsules whole with water. Do not open, crush, or break the lenalidomide capsules. If you touch a broken lenalidomide capsule, wash the area of your body with soap and water.