4. Blood sample collection In total, 12 ml (3/4 of a tablespoon) of blood sample will be collected in 1 SST and 1 EDTA vacutainers in the clinic by trained research personnel. The blood sample will be processed and serum, plasma and puffy coat samples will be aliquot and frozen in -80ºC for future analysis. The DNA samples in the puffy coat will be extracted and used as the normal control sample for the loss of heterozygosity (LOH) analysis. A separate consent will be used for this purpose. We anticipate that all aliquots of serum, plasma and puffy coat will be used up. Any remaining tissue will not be discarded or sold, but will be stored in a locked freezer room at the BC Cancer Agency for a period of up to fifteen years so that results of this study can be confirmed.