Study Medication: The RAD001 dose level of daily schedule will be escalated from 2.5, 5.0, 7.5 to 10 mg/day without splitting, with or without food. The RAD001 dose level of weekly schedule will be escalated from 20, 30, 50 to 70 mg/week without splitting. The dose and schedule of RAD001 in the phase II study will be dependent on the result of phase I study. RAD001 will be supplied by Novartis Co.,