The test of Hypothesis 1 with modified MADRS response rates (Analysis B, see below) will only be conducted if the Cronbach alpha value for the modified MADRS at baseline is at least .80 or within .10 of the unmodified MADRS alpha and still acceptable by standard convention (at least .70). Given the hypothesis tests proposed (see below), response rates will be calculated at each time point from baseline until and including the end of Week 6.