Here we propose to investigate the effects of one particular factor that may influence various cellular measures, namely in vivo drug treatment. Specifically, we are interested in assessing the effect of treatment with lithium, an ion that possesses mood-stabilizing properties. Indeed, lithium is the most effective treatment in bipolar disorder, with approximately 30% of patients achieving complete illness remission and prevention of episode recurrence (Baldessarini and Tondo, 2000; Garnham et al., 2007).