6. Flutamide (Eulexin) treatment within 4 weeks of Cycle 1, Day 1 and Bicalutamide (Casodex) or nilutamide (Nilandron) within 6 weeks of Cycle 1 Day 1 (Exceptions: if progression is documented prior to this time interval, or if patient is deemed by the treating physician to be highly unlikely to respond to AR inhibitor withdrawal (e.g. if PSA did not decline for >/= 3 months in response to AR inhibitor given as a second line or later intervention, or if patient has symptoms attributed to disease progression) only a 3 day washout prior to Cycle 1, Day 1 will be required for any of them.