3. To examine whether nuclear morphology is associated with levels of oxidative stress in the NAF. Correlations will be evaluated with levels of 8-isoprostane, cholesterol, specific fatty acids, 2,6-cyclolycopene-1,5-diol and fat-soluble micronutrients. The potential influence of diet, demographic factors and nature of previous biopsy diagnosis on nuclear morphology will also be examined as a sub-aim in an effort to better understand differences among women in the nuclear morphology of epithelial cells from ductal lavage.