Explants will be cultured in groups of three with the villus surface up on microporous membranes (0.45-_m pore size) contained in Millicell-HA tissue culture inserts (Millipore). The inserts will be placed inside 6-well plastic tissue culture dishes (Costar 3506) along with 1.5 ml of tissue culture medium. Tissue culture medium will be Dulbecco's modified Eagle's medium supplemented with 10% heat-inactivated fetal calf serum, penicillin (100units/ml), streptomycin (100 μg/ml), leupeptin (50 μg/ml), PMSF (1 mM), soybean trypsin inhibitor (50 μg/ml), and dexamethasone (200 μg/ml). Cultures will be incubated at 37°C incubator and gassed hourly with95% oxygen 5% carbon dioxide. Six biopsies from each site will be obtained. Three biopsies will serve as a control and three will be cultured with the addition of Cannabidiol (1 μg/ml). After 24 hours tissue viability will be assessed by addition of Alamar to one of each 3 samples. Change of color from purple to pink indicates viable tissue. The supernatant from the other 4 biopsies will be collected and frozen at -20°C. The biopsies will than be placed in formalin for pathology inspection.