5. Frozen tissue collection In the event of biopsy, tissue will be bisected. Half of the sample will be fixed in the formalin solution and sent to the pathology laboratory for analysis as a normal part of medical diagnosis procedure. Part of this tissue will be kept and used only after the diagnosis has been made. At no time will tissue be removed solely for the purpose of research. The donated tissue will be given a code for identification by the project leader, and will be kept in secure freezers at the BC Cancer Agency until genetic material (DNA and RNA) has been extracted for analysis. A separate consent will be used for this purpose. We anticipate that all donated tissue will be used up. Any remaining tissue will not be discarded or sold, but will be stored in a locked freezer room at the BC Cancer Agency for a period of up to fifteen years so that results of this study can be confirmed.