Short-term vs. long-term measures: Tinnitus loudness matching and MML measures provide quantitative measures about the immediate status of a subject's tinnitus. Loudness and annoyance are more integrative, depending on the subject's perception of the tinnitus, but are still reflective of the immediate tinnitus conditions of the subject. THI and TFI quantify the direct and indirect impact of the tinnitus on the individual. These tools evaluate tinnitus effects that are often cumulative over long periods of time (e.g. depression, insomnia, changes in social interactions). Medications that alter brain chemistry may have an impact on either or both short and long-term tinnitus measures so both categories are being evaluated.