Improvement of relapse free survival has also been observed in the NSABP-B-27 and Aberdeen trials. In the latter trial, improvement in overall survival has also been reported.. A statistically significant improvement in overall survival has not been observed yet in the NSABP-B-27 trial but a longer follow-up of this study is required to better evaluate the impact of including Taxotere (Docetaxel) as part of the neoadjuvant strategy on overall survival of breast cancer. One subgroup of patients in the NSABP-B-27 trial was found in a retrospective analysis to benefit the most. This was the group who achieved a clinical partial response after the first four courses of AC and who received four additional courses of Docetaxel. They benefited from a longer disease free survival.