On the basis of these studies, we have also been given access to proprietary GE software to analyze raw data and have developed a software program that analyses the Doppler pulse flow and external carotid artery pressure tracing raw data to obtain parameters that previously required invasive techniques or laborious manual techniques to calculate. Using this new technique, which is unique to our group and applicable to other conditions that affect the aorta, we can now measure several key variables of aortic vessel function, including vascular distensibility, stiffness indices, impedances, total arterial compliance, reflective wave index, left ventricular work and efficiency. We predict that using this method to make a comprehensive assessment of aortic vascular (dys)function will provide for early detection of vascular changes and enable an improved comparison of the effectiveness of pharmacological treatment of cardiovascular disease in MFS.