What is the proposed sample size? In the pilot study (described above), it was found that after 2 weeks, compared with the placebo group, those assigned to fluticasone experienced a significant decrease in CRP levels from baseline, after adjustments for baseline FEV1, age, and sex of participating patients (57.1% decrease relative to placebo; p=0.042). The (geometric) mean of CRP for this cohort was 4.9 mg/L (95% CI, 3.3 to 7.1). Sample sizes of 200 participants combined in Flovent and Advair group (100 in each) and 50 in the placebo group will be needed.