More recently, several alternative rTMS paradigms have shown promise. Low frequency rTMS applied to right PFC (LFR-TMS), contrary to high frequency rTMS, is known to reduce local cortical excitability [24]. The initial trial of LFR-TMS established its efficacy in a non treatment resistant sample of patients [25]. Funded by a previous NHMRC grant, we have conducted research establishing the efficacy of LFR-TMS as compared to HFL-TMS and placebo (CIA 15):