Interestingly, this combined approach seems interesting for brain tumors, as shown by a recent published trial conducted by Narayana in first-line treatment of gliomas. This phase 2 study combined temozolomide chemotherapy with bevacizumab administration for a dose of 10 m/kg at D14 and D28 during the course of radiotherapy (total dose of 59,40 Gy delivered to the tumor volume). An promising response rate was observed: 7% of complete response and 93% of partial response, the 1-year progression-free survival was 59,3%. The authors confirm the feasibility of this combined approach (13/15 patients completed their treatment). Three grade 3-4 haematological toxicities and 4 non-haematological toxicities (thrombo-embolism and HTA) are related. None intracerebral hemorrhage or death related to the treatment was reported.