Inclusion criteria are as follows: 1) age 18-65 years, 2) a diagnosis of migraine with or without aura for >1 year according to the International Classification of Headache Disorders-IIIb (2013), and 3) 5-25 migraine days per month on average during the preceding 3 months. Women of reproductive ability must use a reliable form of contraception beginning 3 months before study enrollment, throughout the study, and for at least 1 month after study completion.