- Early discontinuation for adverse events V. STUDY DESIGN General Description This is a randomized, double-blind, placebo controlled, crossover study of levetiracetam in healthy older adults. The study is divided into 6 phases, which will occur over a total of 14 weeks: Screen (-2 weeks), Randomization (0 weeks), First Drug Treatment Period (4 weeks), Washout (2 weeks), Second Drug Treatment Period (4 weeks), and Post-Treatment (2 weeks) (Appendix 2). Each Drug Treatment Period is further divided into the Titration, Maintenance, and Taper Phases. Following Screening, subjects will be randomized (1:1) to receive either levetiracetam or placebo the First Drug Treatment Period. After completion of this phase and the subsequent Washout, subjects will receive the alternate therapy in the Second Drug Treatment Period.