III. To provide preliminary data on the individual effects of exercise and ibuprofen, as well as the combined effect of both interventions, on serum pro-inflammatory (MCP-1, IL- 6, IL-8, TNF-alpha, sTNFR2, sTNFR1, IL-1beta) and anti-inflammatory (sIL-1Ra, IL-10) cytokines/receptors in colorectal cancer patients receiving chemotherapy compared to health education and placebo controls.