Standard of care blood tests (whole blood) will be obtained at screening and subsequent visits, depending on HCV medication regimen and health status, in order to assess: HCV genotype, HCV RNA viral load, host IL28B genotype, liver function, full blood examinations, iron studies, vitamin D, lipid profile, clotting profile, alpha-feto protein, HIV RNA viral load and hepatitis B virus serology. In addition, a study specimen for HCV NS3/NS5 sequencing will be collected at screening and stored. Specimens for pregnancy tests will be collected where applicable. Biospecimens from this study will be frozen and stored in secure laboratories at the Burnet and Victorian Infectious Diseases Reference Laboratory, for a minimum of 15 years in a biobank, under custody of the principal investigator.