As noted previously, plerixafor combined with G-CSF provides superior mobilization outcomes in MM and NHL compared to G-CSF alone. It has also been shown to be an effective salvage option for patients failing to collect adequate CD34+ cells with G-CSF alone or chemomobilization [24-26]. However, the high cost of plerixafor has limited its routine use in HPC mobilization. Risk-adapted algorithms have been developed in several institutions to rescue patients at high-risk for mobilization failure and restrict plerixafor use to curtail mobilization costs. Veltri et al. recently reported a single institution comparative analysis of patients with MM and lymphoma who underwent G-CSF mobilization, with plerixafor used either routinely or as needed in patients at risk for mobilization failure. This analysis showed no mobilization failure events with either administering plerixafor routinely to all patients vs. by using a JIT approach, but showed that JIT method was associated with significantly lower collection costs.