14. Any of the following cardiac criteria: mean resting corrected QT interval (QTcF) >470 msec obtained from 3 ECGs; clinically important abnormalities in rhythm, conduction, or morphology of resting ECGs, e.g., complete left bundle branch block, third degree heart block; any factors that increase the risk of QTc prolongation or risk of arrhythmic events; ejection fraction <55% or the lower limit of normal of the institutional standard.