On April 18, 2005, an interim analysis of the first Phase III randomized study confirmed a significant benefit in the use of bevacizumab as first-line treatment for metastatic breast cancer. This multi-center study enrolled 722 women with previously untreated metastatic breast cancer and randomized the patients to receive adjuvant paclitaxel with or without bevacizumab. The trial excluded women who had her-2/neu positive breast cancer unless they received trastuzumab previously or were unable to receive this medication. The interim analysis showed a progression-free survival and early indication of survival benefit with the addition of bevacizumab to chemotherapy compared to chemotherapy alone. These findings were presented at ASCO this year.