Methods Breath testing will be done using the Cyranose ENose in Thoracic Medicine Established protocol for testing from Lung Cancer study, x 2 single expirations into a collection bag Ideally this would be best done when a lesion has been seen by ENT surgeon but BEFORE it is biopsied (to avoid confounding effects on VOCs of tissue disruption by the biopsy) The ENose software allows comparisons of 3 groups of 10 subjects each - 10 Tis/T1, 10 advanced Larynx Ca, 10 smoking controls with demonstrated normal ENT and tracheobronchial tree.