Most patients on clinical trials have tried standard of care treatment unsuccessfully. Little is known, due to the lack of research, demonstrating the impact of CF, CS or Burnout on Clinical Research Nurses. The CRN works closely with oncology patients during the study, developing a close relationship with the patient and family, which exposes the nurse to disturbing patient situations that can be detrimental on psychological health. One-third of the Hematology and Solid Tumor clinical trials at City of Hope National Medical Center are phase 1 trials, which are to determine dose limiting toxicity, not truly for the benefit of the patient. Nurses are forced to care for patients who are likely to die, they leave the organization or CRN position due to intolerance of suffering. This project is important to teach nurses how to recognize and manage CF. This intervention could reduce nurse turnover, increase morale, and improve patient satisfaction, all of which could be a cost savings to the organization.