Myocardial infarction within 12 months Uncontrolled angina within 6 months Congestive heart failure within 6 months Diagnosed or suspected congenital long QT syndrome Any history of clinically significant ventricular arrhythmias; Prolonged QTc interval on pre entry electrocardiogram. QTc must be less than CTC Grade 2 (≤480 msec) using appropriate correction formula with manual read by investigator if required. The ECG may be repeated for evaluation of eligibility after management of correctable causes for observed QTc prolongation currently have a pacemaker) Heart rate <50/minute on baseline electrocardiogram Uncontrolled hypertension