The ALF-MBT will be performed on all patients upon admission into the study (Day 1) and repeated on Days 2, 3, 5 and 7, as close to the same time of day as possible (within ± 4 hours), provided no contra-indications are present. Subjects will be contacted for the Day 21 follow up (21 days after the subject's enrollment into the trial) to determine spontaneous survival, transplantation and occurrence of serious adverse events since the subject's last study treatment.