1. Any approved anticancer therapy for treatment purpose is not allowed, or need to be stopped at least 2 weeks prior to initiation of study treatment; however, the following are allowed: a. Endocrine therapy (SERM, aromatase inhibitor, fulvestrant) b. Palliative radiotherapy for bone metastases > 1 week prior to study treatment c. Stable brain metastasis and asymptomatic treated CNS metastases are allowed, patient must show stable disease by CNS radiographic study >/= 4 weeks from completion of radiotherapy and >/= 2 weeks from discontinuation of corticosteroids