Treatment for early breast cancer involves local therapy that includes surgery and adjuvant radiation therapy as well as systemic therapies including chemotherapy, biological therapy and hormonal therapy. Chemotherapy protocols for breast cancer include different combinations of alkylating agents, platinum derivates and taxanes that are toxic to the ovaries, destroy primordial follicle stockpiles, which directly represent ovarian reserve and can result in infertility and premature menopause [10-12].