• Sample Size: Sample size determination - Assuming a power of 90% and alpha of 0.05, we have calculated that 340 individuals would be needed in each arm to detect a difference in CD4 decline of 50 cells/mm3 between the two groups (SD of 200 cells/mm3) over the two years of follow up. Given a maximum expected loss to follow up of approximately 20% over the 24 months of follow up and a maximum of 20% beginning ARV therapy, we will enroll 1200 individuals in the trial to ensure that 340 individuals are available in each arm for analysis. This sample size will also provide greater than 90% power to detect a 0.5 log difference in log10 HIV RNA levels between the treatment arms.