Patients were randomized into three equal groups 40 patients in each one; In control (C) group did not receive either study drug, Intravenous Tranexamic acid (ITX) group received Intravenous TX 50 mg / kg at the induction of anesthesia followed by infusion of 1 mg/kg/hr. till 6 hours postoperatively while in the topical Tranexamic acid group (TTX) received topical TX 50 mg / kg poured into the pericoredial cavity before sternal closure. Total blood loss and transfusion requirement within the first 24 hours postoperatively were recorded together with hematocrit percentage, platelet counts and coagulation studies. In addition; chest closure time, duration of mechanical ventilation, length of ICU and hospital stay were recorded and the occurrence of re-exploration for excess bleeding, or any other thrombotic or adverse events.