The safety of the study agents will be monitored after the intervention has been initiated. In the community, supervision will be carried out by the physician and the trained research assistants and adverse reactions including diarrhea, vomiting, nausea and other local and systemic reactions recorded. For the all three groups, 3 consecutive days after the each dose of study agent, the participants or their guardians will be interviewed for recall of symptoms by health workers. All side-effects will be recorded up to 28 days in reaction surveillance forms for local and systemic reactions. If any adverse event or serious adverse events notified within the study period field clinic will be available for reporting and possible management of the event. Reported symptoms other than appetite loss will be graded as mild (noticeable), moderate (affecting normal daily activities) or severe (suspending normal daily activities). A clinical record form will be used to record all clinical signs and symptoms. In case of serious adverse effects the data will be entered in a separate form . If required the study subject will be hospitalized at the Mirpur Treatment Center or the ICDDR,B Dhaka Hospital under supervision of the study physicians..