- Hemoglobin < 90g/L, platelets < 100×10^9/L, neutrophils < 2×10^9/L, total bilirubin ≥ 1.25×the upper limit of normal(ULN), ALT\AST ≥ 1.5x ULN), serum creatine ＞ 1x ULN, creatinine clearance rate < 60ml/min, Cholesterol ＞ 7.75 mmol/L and triglyceride ＞ 3 mmol/L, LVEF: < LLN