METHODS: This study sample will include 232 outpatients with a clinician-confirmed diagnosis of PTSD, recruited from the Roudebush VA Medical Center as well as metropolitan area mental health clinicians and military/Veterans' organizations, who will be randomly assigned to receive the Holistic Yoga Program (HYP) or the Wellness Lifestyle Program (WLP). The HYP will involve a standardized 16-week intervention consisting of: 1) in-person group yoga class taught by a yoga instructor registered through the Yoga Alliance at least at the 200 hour level; 2) classes will include yoga postures, breathing practices, deep muscle contraction practices, relaxation practices, and teacher-led discussions to exchange "lessons learned," and introduce relevant aspects of yoga philosophy; 3) guided yoga postures, breath and relaxation practice audio recordings for home-use; and 4) a Participant Handbook to reinforce concepts taught during in-person sessions. The WLP is an attention control comprised of low intensity physical activity and didactics about wellness topics that will also encourage home practice and provide a Participant Handbook to reinforce concepts taught during in-person sessions.