Hemophilia A and hemophilia B are genetic bleeding disorders caused by the lack of ability to produce blood-clotting factor VIII (FVIII) and factor IX (FIX), respectively. Individuals with hemophilia A and B suffer repeated bleeding episodes, which can cause chronic joint disease and sometimes leads to death due to the inability for blood to clot efficiently.The current treatment is intravenous infusion of clotting factor concentrates, either prophylactically or in response to bleeding.