18. Patients with untreated active hepatitis B virus (HBV) (HBsAg positive and HBV DNA ≥ 2000 IU/mL) . But patients with controlled(treated) HBV fulfilling the following criteria can be eligible for the study: HBV DNA＜ 2000 IU/mL , or patients on anti-HBV suppression with HBV DNA＜ 2000 IU/mL before study enrollment.