Phase 1. After two weeks, subjects will return (Visit 2). At this time a blood (10 ml) and urine sample will be obtained and stored for subsequent metabolomic analysis. An exhaled gas sample will be collected and analyzed for nitric oxide concentration using a sensitive chemiluminescence technique. An induced sputum sample will also be obtained using standardized protocols and cell count and differential will be determined. The remainder of the sputum sample will also be stored for subsequent analysis. All tests will be performed in the morning after an overnight fast.