This Fast-Track SBIR project is designed to address the critical need for an effective primary prevention approach for prescription drug abuse (PDA), an urgent public health crisis in the United States. The project involves developing and testing an innovative new approach to the primary prevention of PDA among high school students utilizing e-learning and small group facilitator-led intervention modalities. The intervention is an adaptation of the evidence-based substance abuse prevention approach called Life Skills Training (LST). The adapted intervention will address the relationship between PDA and alcohol, tobacco and other drug (ATOD) use and abuse; positively change social norms surrounding ATOD and PDA; discourage diversion of prescription medications; enhance protective factors by building social and self-regulation skills through interactive learning and behavioral rehearsal scenarios.