- Investigate the growth factor and cellular profile of different pediatric and adult malignancies and correlate this with disease course by measuring circulating levels of growth factors, microvesicles and bone marrow-derived cells including hematopoietic progenitor cells (HPCs), endothelial progenitor cells (EPCs), mesenchymal progenitor cells (MPCs) and matrix metalloproteases (MMPs) in the blood and urine of pediatric and adult patients without malignancy, as well as patients with pediatric and adult malignancies, and determining if these levels predict development of metastasis, or change during treatment, such as when undergoing surgery, chemotherapy and other treatments such as immunotherapy.