4. Check if a patient satisfies required eligibility. Inquire about the background of a patient, past medical history, a history of surgery, and prior treatment drugs, and perform physical exam, vital signs (incl. ECG), hematology, blood biochemistry, pregnancy test (for women of childbearing potential), HbA1c, and fasting plasma glucose (FPG) as well as plasma EPA/DHA, FFQ and metabolomics.