We will determine feasibility, toxicity and MTD; assess clinical impact and effect on Treg and Tcon homeostasis; and determine whether these effects can be maintained and the extent to which they persist. We will also assess for predictors of response to therapy, both clinical (e.g., patient, disease, concurrent agents) and biological (e.g., degree of Treg expansion; Treg:Tcon ratio; Treg function).