A combination derived from the established TAC (Taxotere, Adriamycin, Cyclophosphamide) regimen but which uses Epirubicin, a less cardiotoxic analogue of Doxorubicin (Adriamycin), will be tested. Those Her-2 negative patients whose response to the first 4 courses of induction TEC is less than a complete remission, will have their treatment changed to a second line regimen, Navelbine-Avastin-Xeloda ("NAX"), with the intention of capturing a better response prior to surgery. Those who are Her-2 positive will initially also receive TEC but subsequent therapy will include Trastuzumab (Herceptin) whether they respond well or not to TEC.