Systemic lupus erythematosus (SLE) is an autoimmune disease associated with multiple organ involvement, among which kidney involvement, also known as lupus nephritis (LN), is quite common in SLE. LN is associated with a more than four-fold increase in mortality in patients with SLE. The management of SLE and LN comprises timely and coordinated management consisting of initial or induction phase of aggressive immunosuppression to bring the active disease under control followed by maintenance phase. The initial phase usually lasting for six months consists of treatment with steroid and cyclophosphamide or mycophenolate mofetil. So far there is no study published regarding the efficacy and adverse events of such treatments in Nepal. So, this study aimed to evaluate and compare the effectiveness and safety profile of mycophenolate mofetil and intravenous pulse cyclophosphamide in induction therapy of LN in Nepalese population.