- Bone Marrow Reserve: absolute neutrophil count (ANC) ≥1.5 x 109/L prior to treatment, platelets ≥100 x 109/L, and hemoglobin ≥10 g/dL. Patients may receive erythrocyte transfusions to achieve this hemoglobin level at the discretion of the investigator. Patients may be allowed erythropoietin of choice as per standard of care.