Patients in the CYC group received intravenous cyclophosphamide (CYC) in the dose of 0.5 to 1 gram per m2 of body surface area. The medicine, which is available in the strength of 1 gram in powder form, was first dissolved in 20 ml of normal saline. Only15 ml of this preparation was mixed in 100 ml of normal saline and was infused over a period of one hour. CYC was not given to those patients who had total leukocyte counts (TLC) less than 2500/mm3. Those patients were re-evaluated after one week and intravenous pulse CYC was reinstituted if the total leucocyte count (TLC) exceeds 2500/mm3. Pulse CYC was administered every month for a total of six infusions.Patients were monitored monthly and the details were recorded. During follow ups, any adverse events in between were noted and detailed physical evaluation was done and all baseline investigations (except USG abdomen, chest X-ray, serum anti nuclear antibody (ANA) and anti double strain deoxy-ribonuccleic acid (anti dsDNA), complement factor 3 (C3) and complement facotr 4 (C4) level) was repeated. Fasting lipid profile was repeated at the end of third and sixth month of treatment.