Several phase III studies comparing classical anthracycline schedules with anthracycline plus taxane treatment have performed retrospective analysis classifying patients between the different breast cancer subtypes. Results from those analysis showed that TNBC/BLBC patients treated with classic anthracycline regimens were having a very poor outcome (similar or in some of these studies even worse than the HER2 overexpressing patients before the trastuzumab era). In those studies the TNBC/BLBC populations were the ones benefiting the most from the taxane addition.