The P2Y12 and arachidonic acid pathways appear to be linked. P2Y12 inhibition has been shown to reduce TXA2 release from platelets (Armstrong, Leadbeater et al. 2011) and potentiates the antiplatelet effect of PGI2 in vitro (Cattaneo and Lecchi 2007). Ticagrelor acts as a more potent P2Y12 inhibitor than clopidogrel (Storey, Angiolillo et al. 2010) and therefore may contribute more to this.