In this study, the treatment (applied twice daily) with the cream containing 5% Vitreoscilla filiformis extract was found to be safe and well tolerated. Moreover, this extract significantly alleviated AD in older children (from 7 years old) and adults compared with vehicle treatment (p=0.008; Wilcoxon signed ranks test). The therapeutic effects of the extract were observed within the second week of the application and steadily increased thereafter. This effect of the cream containing 5% Vitreoscilla filiformis extract appeared to have a rapid onset especially in regard to pruritus as demonstrated using the mEASI index. Paired testing confirmed a significant difference in the decrease of pruritus on the 5% Vitreoscilla filiformis extract treated side at day 28 (p=0,046, Wilcoxon exact signed ranks test). (Gueniche et al. 2006).