Management of enrolled women HPV negative women will receive at home the results of the screening test and they are re-invited after 5 years according to the HPV screening protocol. All women who resulted in being HPV positive will be contacted by phone to perform colposcopy and a counselling on HPV and cervical cancer risk. If the colposcopy will be positive, a biopsy will be taken, and each women will be followed according to the protocol of HPV screening program in Tuscany. If colposcopy will be negative, women will be re-invited to undergo control with HPV test within a year's time. During colposcopy also a Pap test will be taken to guide the post colposcopic follow-up according to the protocol approved in Tuscan Region. If a woman with hr-HPV did not attend, efforts were made to contact her again by phone and then also by letter.