To the author's knowledge, there has only been one study examining bone loss in menopausal women with gynecologic cancers undergoing chemotherapy (5). This was a small (n=25) prospective observational study with no controlled treatment arm. The authors observed a higher incidence of baseline bone loss and significant additional loss during chemotherapy treatment. Bone loss has also been described in breast cancer patients undergoing chemotherapy (6,7). Laboratory and animal studies demonstrate a deleterious effect of cytotoxic chemotherapy on protein synthesis and DNA replication, resulting in altered or diminished bone formation (8-10). We know of no intervention studies in postmenopausal women with cancer undergoing chemotherapy i.e., comparing different osteoporosis prevention strategies. Estrogen therapy is often contraindicated in gynecologic malignancies and alternative treatments for bone loss prevention are not routinely used by gynecologic oncologists. At present there are no guidelines and/or recommendations in the Gynecologic Oncology community for preventative treatment of bone loss in individuals undergoing chemotherapy (not even calcium and/or vitamin D supplementation recommendations).