8. Continued from #7: Any history of venous or arterial thromboembolism including deep venous thrombosis or pulmonary embolism. Patients with a history of treated prior superficial or catheter associated will not be considered as significant embolism and after discussion with PI will not be excluded from eligibility. Uncontrolled hypertension (diastolic blood pressure >90mmHg; systolic >140mmHg). Patients with hypertension should be under treatment on study entry to effect blood pressure control