Subjects in Expansion Cohort 1 or Expansion Cohort 2 with more than one injectable tumor ≥ 1 cm in diameter will be eligible for treatment of an additional injectable tumor 28 days to 120 days after prior PV-10 administration provided that any prior treatments with PV-10 were well tolerated. This may be repeated until all injectable tumors ≥ 1 cm in diameter have received PV-10.