Assessment of Safety and Feasibility The safety and feasibility of regular phlebotomy will be determined by assessing the proportion of patients who can complete the 12 planned phlebotomies. Delays in phlebotomy and reasons for stopping the phlebotomy program will be documented. At each visit, patients will have a comprehensive assessment prior to starting and after completing the phlebotomy. This assessment will include determination of pain at phlebotomy site, local infection and an assessment of symptoms of anemia including presyncope, fatigue and dyspnea. The patient's pulse, blood pressure, respiratory rate and temperature will also be determined before and following the phlebotomy.