Cirrhosis and congestive heart failure (CHF) are major clinical disease states characterized by renal sodium and water retention with edema formation. Abnormalities of circulatory and volume homeostasis in these diseases elicit neuro-hormonal responses influencing renal function and leading to retention of sodium and water.Cytokines constitute a complex network of molecules involved in the regulation of the inflammatory response and the homeostasis of organ functions. Moreover cytokines coordinate physiologic and pathologic processes in the liver, such as liver growth and regeneration, as well as inflammatory processes including viral liver disease, liver fibrosis and cirrhosis .