2. Patients with congestive heart failure, myocardial infarction, unstable angina pectoris or arterial thrombotic event within the past 12 months, uncontrolled hypertension (SBP>160 or DBP>90), uncontrolled or clinically significant arrhythmia, grade II or greater peripheral vascular disease or prior history of stroke or TIA (transient ischemic attack).