4.1.14 Subjects must be determined by the investigators to have at least one fully active regimen available to them other than the regimen they are receiving at study entry. The determination of whether or not an alternative regimen is available must take into account both the subject's antiretroviral history and any previously obtained resistance testing. A valid alternative regimen must meet the recommendations for an active regimen outlined in the current DHHS guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents (93).