Absolute neutrophil count (ANC) ≥ 1.5 X10^9/L, Platelets ≥ 100 X10^9/L, Hemoglobin ≥ 9g/dL, aPTT ≤1.5 x ULN, Total bilirubin ≤ 1.5 mg/dL, ALT and AST ≤ 2.5 x ULN if no liver involvement or ≤ 5 x ULN with liver involvement, Creatinine < 1.5 x ULN concurrent with creatinine clearance >50 mL/min.