The primary outcome will be the difference between two time intervals, individual 1st and 8th peg insertion time, in 1st run (8-consecutive peg insertions) with right hand, which will be compared between de novo PD and advanced PD. The secondary outcomes are: (a) the difference in progressive changes of six time values for six runs; (b) the beneficial effect of levodopa and rTMS on sequence effect; and (c) correlation between the time intervals of first and eighth peg insertion and the scores of two subjective fatigue scales, i.e., Fatigue Severity Scale (FSS) and Multidimensional Fatigue Inventory (MFI).