This is a prospective, observational study. It will include a neurological and cognitive examination upon arrival in the neuro-rehabilitation department. It is expected that the patient will remain stable or improve during the stay in neuro-rehabilitation. In case of neurological aggravation, if a Trephined Syndrome is suspected (other causes must be well dismissed such as recurrence of stroke, haemorrhage, infection, hydrocephalus, electrolytic or metabolic disorder, toxic and metabolic abnormalities, epileptic crisis etc) a new neurologic evaluation will specify the type of deficit. The examination will take place in the morning and evening after a day of therapies to eventually observe the neurological aggravation due to orthostatism. In the event of a evident worsening due to orthostatism, as usual, a bed rest awaiting cranioplasty will be offered to the patient. In all patients (improved compared to admission, stable or worse) an examination at 7-10 days before the cranioplasty will be performed and then repeated 1-4 days before and then 1-4 days after the cranioplasty. The delay of cranioplasty in relation to the date of craniectomy, the date (if known) when a cranioplasty was considered possible in terms of radiological and clinical evaluation and the date of start of the Trephined Syndrome will be recorded. Complications related to cranioplasty will be noted. At the patient's discharge from neuro-rehabilitation department a final examination will be performed. The mentioned evaluations will be carried out by the medical residents in charge of the patient under the supervision and assistance of the study investigators.