If the trial continues, for all successive cohorts after the first, since the decision of which dose to assign utilizes all of the dose-toxicity data from all patients treated previously, there are too many possibilities to enumerate. For example, there are 12 possible outcomes for the second cohort, and this number increases exponentially as the trial progresses. However, at any point in the trial, the estimated probability of toxicity at each dose based on the most recent data may easily be estimated and this information made available to the investigators. Additional safety provisions are that the middle dose of 160 µg/kg may not be skipped when initially escalating from 80 µg/kg, and the trial will be terminated early with no dose chosen if the lowest dose is excessively toxic.