7. Experimental protocol with Functional Magnetic Resonance (fMRI): an experimental paradigm similar to that used by Binkofski et al., 1999 will be used to assess activation of sensorimotor circuits related to grasping/manipulation actions before AOT and at the end of AOT treatment, with the aim to study re-organization within these circuits or to assess the recruitment of alternative areas/circuits following the treatment. Subjects will lay supine in the scanner with the head immobilized with a pneumatic cushion and the eyes open. The room will be dark. The subjects will be asked to manipulate continuously either five complexes objects or a sphere. Each object will be placed into the participant's hand at the beginning of an activation phase and removed at the end of it by one of the experimenters. As a control, participants will be asked to manipulate a sphere. Manipulation actions will include movements of all finger. Both hands will be tested, separately. The testing order will be randomized across subjects. A block design paradigm will be used with each block lasting 20 s. Neuroradiological images will be analyzed with MATLAB (Mathworks Inc., Natiek, MA, USA) and statistical parametric mapping package SPM96 (Friston et al., 1994a,b; 1995b, 1997; Poline et al., 1995; Worsley & Friston, 1995).