1. Design and study population: We have carried out a randomized controlled trial conducted simultaneously in the smoking cessation center and the department of cardiology at the University Hospital of Monastir (Tunisia). This study was performed from January 2015 to Jun 2016 with a mean of 24 weeks of run-up and 24 weeks of follow-up. We have included patients aged more than 18 years, hospitalized with an ACS actively smoking at the time of inclusion, motivated to quit smoking, able to provide informed consent and willing to participate in a clinical study including a follow-up examination every 2 weeks after hospital discharge. Active smoking was defined as smoking one cigarette or more (or water pipe) per day during the month preceding the hospital stay. Non-inclusion criteria were the refusal of assistance of smoking cessation, inability to follow-up clinical visit (professional, regional or physical hindrance), diagnosis of depression or of serious health condition at admission (ventilated patient, cardiogenic shock, etc).