2. To obtain breast lavage fluids from women with proliferative breast disease and to characterize the nuclear morphology of breast epithelial cells in the breast lavage fluid. We will quantify various measures commonly used in biopsies including nuclear diameter, circumference, area, roundness and nuclear:cytoplasmic area ratio. These measures have been shown to be related to breast cancer risk. If there are sufficient cells, analysis of oxidative DNA damage will be made using the comet assay.