Goal: to to examine the formation of postvaccination immunity and evaluate the therapeutic effect of bacterial vaccines in patients with inflammation diseases of bronchopulmonary system. Objectives of the study: assessment of microbiocenosis mucous membranes of the upper respiratory tract in patients with bronchopulmonary pathology before and after use of bacterial vaccines. Identification of mayor lymphocytes subpopulations, proinflammatory cytokines, inflammatory markers in patients in the dynamics of the vaccination process. Study the profile of humoral immune response in patients under different schemes of vaccination. Detection of levels of autoantibodies against tissue antigens in the sera of vaccinated patients with inflammatory diseases of the respiratory tract. Assessment of the clinic and functional status bronchopulmonary system in the immunized patients. Development of methodical recommendations / study guides for the improvement of therapy in patients with different inflammation diseases of the respiratory tract.