Exclusion criteria will be: (1) patients under 18 or over 65 years of age; (2) use during the previous three months of drugs for acute headache on ten or more days per month; (3) duration of disease less than one year; (4) history of major psychiatric diseases, significant cognitive disorders, significant chronic pain other than headache, or in general from a secondary headache; (5) any kind of ongoing prophylactic treatment or taking place during the whole study period; (6) estroprogestinic therapy started or modified during the whole study period.