Data from the department of Radiation Oncology at Northern Sydney Cancer Centre demonstrates that only 17% of patients experience a pCR, which is in keeping with other series [4]. In this study of 48 patients, 38% showed evidence of tumour shrinkage 2 weeks into treatment as demonstrated on a Cone Beam CT scan taken during radiotherapy. 44% of these patients demonstrated a pCR following surgery. In the remaining 62%, none of these patients had a pCR. This confirms the principle that early response during radiation based only on gross tumour shrinkage can be a powerful predictor of subsequent response.