Possible limitations It is debated whether or not diabetes can attenuated the efficacy of RIC treatment. Data from randomised clinical trials are conflicting . As the patients in the present study population will have some degree of neuropathy this may attenuate the effect of RIC on our outcomes. However a recent study has showed an effect of RIC on diabetic foot ulcers contradicting the above-mentioned hypothesis, as all diabetes patients with foot ulcers have some degree of neuropathy .