This trial will be a double blind, placebo-controlled multi-center study comparing the effects of Advair, Flovent and placebo on serum CRP in COPD. All study participants will first undergo a run-in phase during which all will be treated with Flovent 500 mcg bid. This will be followed by a withdrawal phase wherein all participants will be FREE of any ICS or LABAs for 4 weeks. After the withdrawal phase, the participants will be randomly assigned (using a computer generated algorithm) to one of three arms: placebo; Flovent; or Advair Run-In Phase (4 weeks): The use of ICS, theophyllines, and leukotriene modifiers, LABA will be prohibited and subjects will be maintained on Flovent 500 mcg bid. Regular use of tiotropium and as needed use of short-acting β2 (salbutamol) and/or anti-cholinergic (Atrovent) will be allowed.