Materials and methods: 40 patients were allocated: Chronic periodontitis patients (PC) (n=20) and breast cancer with chronic periodontitis patients (CAN/PC) (n=20). The clinical parameters: probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI) and levels of IFN-γ, IL-4, IL-10, TGF-β, IL-17, IL-2, IL-6, IL-1β and TNF-α in gingival crevicular fluid (GCF) were evaluated at baseline, 45 and 180 days after therapy.