This is a phase 1 trial of anti-EGFR-immunoliposomes, an investigative nanoparticle targeted against EGFR-overexpressing tumor cells. The investigators have constructed anti-EGFR immunoliposomes by using Fab' fragments of the chimeric MAb cetuximab (C225, cetuximab, erbitux™, ImClone Systems Corp., NY, USA; Merck KGaA, Darmstadt, Germany), which were covalently conjugated to the liposome membrane. This approach was designed to provide maximal drug delivery to cancer cells via a receptor-targeted and internalizing drug carrier that is stable, non-immunogenic, long-lived with extended blood and tissue residence times and capable of delivering large payloads of diverse types of drugs.