Study participants will be randomly assigned to either placebo or COQ10 capsules, (AOR - Advanced Orthomolecular Research Inc. 19 St NE Calgary, Alberta, NHPD registration codes 135307). Study participants will take 600 mg of CoQ10 orally once a day with breakfast or identical placebo capsules for 2 months prior to an IVF cycle and up to 3 cycles if pregnancy does not occur. On cycle day 3, subjects will start the ovarian stimulation for in vitro fertilization while continuing the consumption of the supplements. The controlled ovarian stimulation (COH) will consist of the microdose GnRH agonist flare protocol, which is the clinic's standard protocol for older women. COH will be done using recombinant FSH (Puregon; Schering-Plough Inc.,Mississauga, ON, Canada) or human menopausal gonadotropins (Menopur, Ferring Inc, Oakville, ON, Canada) 150 units twice daily S.C. and Buserelin Acetate ( Superfact, Sanofi-Aventis Canada Inc, Laval, Quebec) 0.05 mg subcutaneously B.I.D, and will continue until the day prior to 10,000 units human chorionic gonadotropin (hCG) (Pregnyl, Organon). The dosage will not be changed and must be maintained for the duration of the study. Both drugs will continue daily until follicular development is considered adequate (at least 3 follicles >17 mm, and the E2 level is acceptable for the number of follicles present) at which time the hCG will be injected to trigger final follicular maturation. Oocyte retrieval will be done 36 hours later by vaginal ultrasound guided needle aspiration and with the use of local anesthesia and mild sedation. At the time of retrieval, subjects will collect 2 mL of saliva, in addition, 2 mL of follicular fluid will be collected from the first follicle aspirated from each ovary for determination of coQ10 activity by arNOX assay. AS it is not possible to measure CoQ10 levels in a single cells (e.g. oocytes), FF represents direct cellular environment that can reflect the metabolical profile of this cell. After retrieval, the oocytes will be fertilized with ICSI in order not to contaminate the maternal DNA during polar body biopsy sample with sperm DNA. On the following day, all the oocytes with 2 pronuclei will undergo a biopsy of one or both polar bodies.