Furthermore, patients with reduced LV function (WMSI <= 1.3) and with reduced global LV function (MPI > 0.55) will be included in the study and irbesartan will be added to an ACE-inhibitor compared to usual care. This patient will be included in the secondary objectives and therefore no sample size estimation has been performed. 100 patients are estimated to be enrolled in this study group and will be used for descriptive purposes.