BRL 49653C has also been examined in combination with glyburide (glibenclamide). BRL 49653C was administered 2mg bd to NIDDM patients receiving stable doses of glyburide for seven days. No changes were observed in either the 24 hour glucose or insulin profiles, suggesting that the combined treatment is not associated with any acute pharmacokinetic interaction that would likely result in an acute untoward pharmacodynamics effect.