The ICONIC is a nested case-control study based similarly upon the dynamic COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry, encompassing a well-characterized patient cohort that is capable of detecting a meaningful association between APCs and future ACS. ICONIC will employ CCTA to comprehensively determine whether coronary APCs beyond traditional angiographic measures of CAD will be implicated in future ACS, and further, to effectively prognosticate gender-specific risk for future ACS. To this end, ICONIC will essentially examine the primary hypothesis that APCs within coronary plaques implicated in future ACS differ from APCs not implicated in future ACS. Secondly, in order to compare the disparity in coronary plaques for women versus men who subsequently experience a future ACS, ICONIC will test gender-specific difference in plaque characteristics among men and women who will experience a future ACS.