Hypothesis We hypothesize that the long-term RIC treatment can improve PAD. PAD is caused by both micro- and macrovascular deficits. Reduced microvascular circulation can lead to distal nerve damage which in turn can both reduce peripheral circulation and cause tissue degeneration. Reduced macro vascular function is a direct cause of peripheral ischemia (2). It is possible that RIC could attenuate the pathophysiological processes in the micro- and microvasculature related to PAD by the abovementioned mechanisms and thereby improving of both neuronal and vascular function.