i. High-risk chromosomal translocations by FISH: t(4;14), t(14;16), t(14;20), del(17p), del(1p), amplification 1q ii. MyPRS GEP-70 high-risk signature either at diagnosis or at time of registration for the study iii. LDH > 300 U/L at diagnosis iv. Plasma cell leukemia v. Relapse from prior therapy within 12 months