15. Inadequate bone marrow reserve or organ function as demonstrated by any of the following laboratory values: Absolute neutrophil count < 1.5 x 10 (exp9)/L; Platelet count < 100 x 10 (exp9)/L; Hemoglobin <90 g/L; ALT and/or AST >2.5 times the upper limit of normal (ULN) if no demonstrable liver metastases or >5 times ULN in the presence of liver metastases; Total bilirubin >1.5 times ULN; Creatinine >1.5 times ULN concurrent with creatinine clearance <50 mL/min