We anticipate the rate of HBeAg seroconversion, primary efficacy parameter, to be around 35% at the end of 3-year entecavir therapy, but decreases to be 30% at the end of 24-week post-treatment follow-up. We also anticipate that by combining Pegasys, the rate of seroconversion at the end of treatment is 50% and at the end of 24-week post-treatment follow-up could be 45%. With a 5% nominal significance level (one-sided), 128 patients per group under a 1:1 ratio (a total of 256 patients) will provide 80% power to detect a difference of 15% in treatment response rates between group I and II. Because this will be a 4-year study for each patient, we thus anticipate that the dropout rate may be as high as 15%. Accordingly, a total of 294 patients will be recruited, in order to account for a dropout rate of up to 15%.