Patients will be followed for 28 days. PCs will be monitored every day until 14 days, followed by tests twice a week. Liver and renal function, coagulation function, inflammatory biomarkers (CRP, PCT), and the severity of the disease(SOFA, APACHEǁ) will be monitored before treatment, followed by tests twice a week. And then, the number of platelet transfusion, the length of ICU stay, days free from advanced cardiovascular/respiratory/ renal support, bleeding events, and any adverse effects will be recorded before and after treatment.