6. Patients must have adequate organ functions as defined below: Neutrophils greater or equal than 1,500 /microliter. Platelets greater or equal than 100,000 /microliter. Total bilirubin smaller or equal than 1.5 x ULN (upper limit of normal) (except patients with Gilbert's syndrome, who must have a total bilirubin smaller or equal than 3.0 mg/dL). ALT smaller or equal than 3 x ULN or smaller or equal than 5 x ULN if liver metastases persist. Serum creatinine smaller or equal than 1.5 mg/dL or calculated creatinine clearance greater or equal than 50 mL/minutes