In comparison with best supportive care, Docetaxel (Taxotere) has shown a benefit in overall survival for the second line treatment of NSCLC (31,32). Patients with prior exposure to paclitaxel were excluded from TAX 317 trial (29). But in TAX 320 trial (30) many patients had received Paclitaxel prior to enrollment (31% of patients in Docetaxel 100 mg arm, 42% of patients in the Docetaxel 75 mg arm and 41% of patients in the control arm. Authors were able to evaluate retrospectively, what impact, if any, prior Paclitaxel exposure may have had on response and survival with Docetaxel. Partial response rates were equivalent in the cohort of 91 patients who had received prior Paclitaxel (10.5%) and the group of 157 patients who had not received prior Paclitaxel (8.5%). In a similar analysis of survival data, prior Paclitaxel therapy had no bearing on the survival advantage seen with Docetaxel.