A prospective observational study will be conducted and cases will be recruited by multi-center cooperation. Investigators plan to collect 100 schizophrenic patients as case group, 100 healthy people as control group. Investigators use the single drug of risperidone in the treatment of schizophrenia patients and follow up the patients on day 1, the third week, the third month, the sixth month and the first year. There are two objectives: