Features of infections including pyrexia, leukocytosis in peripheral blood, C-reactive protein and evidence of focal infections like positive blood, throat/tracheal aspirate or urine culture for pathogenic organisms etc. will be documented per protocol as per respective standard case record forms for specific hospital acquired infections (HAI). Clinical and laboratory evidence of HAI especially CLABSI will be monitored and explored at anytime during the SVPE procedure until the second day of withdrawal of the central venous catheter. A definite or strongly suspected CLABSI will be followed up until discharge to document the ultimate fate.