Depression and suicidal ideation/attempt/death are major causes of morbidity and mortality from psychiatric illness. The World Health Organization (2009) lists depression as the leading cause of years lost due to disability worldwide. Suicide is the 9th most common cause of death in Canada with 1.6% of Canadians ultimately dying from suicide (Statistics Canada, 2012) and the 2nd most common cause of death in young people after accidental deaths. The investigators' data show that at least 50% of people dying from suicide in Toronto suffer from depression with a small proportion ~12% suffering from BD. These data underscore the urgency of developing new treatments for both MDD and BD but also the suicidality that is often associated with them.