The goal is to screen and enroll the subjects in either the ED or inpatient ward within 6 hours of diagnosis, as this is within the theoretical window prior to the development of systemic inflammation. At the discretion of the attending physician, however, treatment can begin in the ED or inpatient ward before enrollment in the study; patients will not have to wait for necessary treatments. Patients will still be eligible to participate in the study if treatment was begun in the ED or inpatient ward. The randomized treatment may end up being the same or different than what was originally ordered by the attending physician. If any such changes in treatment plan are noted, this will be considered for the data analysis.