This study is trying to find the best dose of ZIO-101. At first, 3 patients will be assigned to the first dose level. They will be followed to evaluate their side effects for a period of 4 weeks before 3 more patients are enrolled. If none of the patients develop serious side effects, the dose escalation will continue. If 1 of the 3 patients in a particular dose level develops significant side effects, 3 more patients will be enrolled at that level. If 2 or more of the 6 patients develop serious side effects, then the escalation will finish and all future patients on this study will be treated at a lower dose level (half way between this level and the previous one).