diff --git "a/task48_biolord_text_matching.json" "b/task48_biolord_text_matching.json" new file mode 100644--- /dev/null +++ "b/task48_biolord_text_matching.json" @@ -0,0 +1,36034 @@ +{ + "Contributors": [ + "BioLORD" + ], + "Source": [ + "BioLORD" + ], + "URL": [ + "https://huggingface.co/datasets/FremyCompany/BioLORD-Dataset" + ], + "Categories": [ + "Text Retrieval" + ], + "Definition": [ + "Given a definition and a list of concepts, match the definition to the correct concept." + ], + "Reasoning": [], + "Input_language": [ + "English" + ], + "Output_language": [ + "English" + ], + "Instruction_language": [ + "English" + ], + "Domains": [ + "Medical Knowledge" + ], + "Positive Examples": [], + "Negative Examples": [], + "Instances": [ + { + "input": "Definition: something described as this gene plays a role in apoptosis, cell differentiation and regulation of transcription during the cellular response to stress.\nConcepts: Jun kinase (MAP Kinase Gene)\tRapidly Expanding High-Avidity Cytotoxic T Lymphocyte (T-Cell Marker)\tAntifungal drugs (Anti-infection drugs)\tCYP17 Inhibitor (Androgen Antagonists)\tDecreased lymphocyte proliferation in response to anti-CD3 (Cell or Molecular Dysfunction)", + "output": "Jun kinase (MAP Kinase Gene)" + }, + { + "input": "Definition: Gene or Genome described as human KLK15 wild-type allele is located in the vicinity of 19q13.41 and is approximately 6 kb in length. This allele, which encodes kallikrein-15 protein, plays a role in protein degradation. Expression of the KLK15 gene is up-regulated in prostate cancer.\nConcepts: Grade 3 Perforation Bile Duct, CTCAE (Perforation Bile Duct, CTCAE)\tKLK15 wt Allele (KLK15 gene)\t3-hydroxybenzaldehyde:NAD+ oxidoreductase activity (aldehyde dehydrogenase (NAD+) activity)\tchemical cleavage (Biophysical Processes)\tDLQI1-Affected Social, Leisure Activity (DLQI Questionnaire Question)", + "output": "KLK15 wt Allele (KLK15 gene)" + }, + { + "input": "Definition: Intellectual Disability described as a rare genetic syndromic intellectual disability disorder with characteristics of variable degrees of intellectual disability, behavioural problems (including attention deficit and hyperactivity disorder, autism spectrum disorder, and aggressiveness) an altered sleeping pattern and delayed speech and language development associated with disruption of ankyrin 3 (ANK3 gene). Additional features observed may include muscular hypotonia and spasticity. Epilepsy, chronic hunger and dysmorphic facial features have been reported.\nConcepts: Ankyrin 3 related intellectual disability, sleep disturbance syndrome (Intellectual Disability)\tmucosal administration (Therapeutic or Preventive Procedure)\tGas cylinder holder (holder)\tBlood lipids (Organic Chemical)\tcytarabine and daunorubicin (Pharmacologic Substance)", + "output": "Ankyrin 3 related intellectual disability, sleep disturbance syndrome (Intellectual Disability)" + }, + { + "input": "Definition: Immunologic Factor described as DEFENSINS found in azurophilic granules of neutrophils and in the secretory granules of intestinal PANETH CELLS.\nConcepts: Code Qualifier (Conceptual Entity)\tcontraction muscle skeletal (Organ or Tissue Function)\tactivation of defense response to oomycetes (positive regulation of response to biotic stimulus)\tDefensin, alpha (Amino Acid, Peptide, or Protein)\tLEC01-Sudden Violent Death: Learned (Intellectual Product)", + "output": "Defensin, alpha (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Surgical procedure on soft tissue described as surgical reshaping of the gingivae and papillae for correction of deformities (particularly enlargements) and to provide the gingivae with a normal and functional form, the incision creating an external bevel.\nConcepts: interleukin-26 production (Organism Function)\tblood (metabolic aspects)\tCortical actin cytoskeleton (Region of cytoskeleton)\tSpecial diet management individual each 15 minutes (Therapeutic or Preventive Procedure)\tGingivoplasties (Other operations on teeth, gums, and alveoli)", + "output": "Gingivoplasties (Other operations on teeth, gums, and alveoli)" + }, + { + "input": "Definition: something described as insulinoma-associated protein 2 (566 aa, ~59 kDa) is encoded by the human INSM2 gene. This protein plays a role in cell growth regulation and tumor suppression.\nConcepts: Maternal status: intrapartum (Finding)\tnonelectrolyte transport (Biological Transport)\tAPOPLEXY, EMBOLIC (Cerebral Embolism and Thrombosis)\tInsulinoma-Associated Protein 2, human (Transcription Regulatory Protein)\tFLJ22720 (Gene or Genome)", + "output": "Insulinoma-Associated Protein 2, human (Transcription Regulatory Protein)" + }, + { + "input": "Definition: Finding described as a disorder characterized by a reduction in the strength of the muscles on the right side of the body.\nConcepts: regulation of protein localization to meiotic spindle pole body (regulation of spindle organization)\tMuscle Weakness Right-Sided (Nervous System Disorders, CTCAE)\tARHGEF2 gene (Gene or Genome)\t852-A (Immunologic Factor)\tSlow-twitch muscle fiber (Skeletal Myocytes)", + "output": "Muscle Weakness Right-Sided (Nervous System Disorders, CTCAE)" + }, + { + "input": "Definition: Potency Unit described as a dosing unit equal to the amount of active ingredient(s) contained in a swab.\nConcepts: Streptococcus pneumoniae Serotype 20 IgG Antibody Measurement (Laboratory Procedure)\tALPHA-GLOBULIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tLasers, CO2 (Lasers, Gas)\tTSCC0126 (TSCC Questionnaire Question)\tSwab Dosing Unit (Unit dose)", + "output": "Swab Dosing Unit (Unit dose)" + }, + { + "input": "Definition: something described as cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells; although these receptors were first identified in the immune system, many have important functions elsewhere; not all immunologic receptors are tree'd under this term.\nConcepts: Strategic Supplement Program (Research Support as Topic)\tOsteophytes in non-axial joints present (General X-ray Findings)\tImmunological Receptors (Immunologic Factor)\tpositive regulation of glomerular metanephric mesangial cell proliferation (positive regulation of glomerular mesangial cell proliferation)\t5q31.1 (Chromosome band)", + "output": "Immunological Receptors (Immunologic Factor)" + }, + { + "input": "Definition: Organism Function described as the appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\nConcepts: partial trisomy chromosome 7p distal (Disease or Syndrome)\tsuperior temporal gyrus development (anatomical structure development)\tsibling relationship (Social Behavior)\tSepal (Plant)\tIFND production (type I interferon production)", + "output": "IFND production (type I interferon production)" + }, + { + "input": "Definition: Eukaryote described as an order of insects comprising the sucking lice, which are blood-sucking ectoparasites of mammals. Recognized families include: Echinphthiriidae, Haematopinidae, and Pediculidae. The latter contains the medically important genera affecting humans: PEDICULUS and PHTHIRUS.\nConcepts: Defect Type Code (Code)\tacetylcholine hydrolase (Enzymes)\tSucking louse (Anoplura)\tIntraduralRoute (Functional Concept)\tPublic Health Systems Research (Biomedical Occupation or Discipline)", + "output": "Sucking louse (Anoplura)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid.\nConcepts: regulation of renal albumin absorption (regulation of renal system process)\tInsert (Biomedical or Dental Material)\tBanff Renal Quantitative Criteria Score (Intellectual Product)\tDEVICE, BIOPSY, ENDOMYOCARDIAL (Medical Device)\t3-chloroacrylic acid metabolism (Molecular Function)", + "output": "3-chloroacrylic acid metabolism (Molecular Function)" + }, + { + "input": "Definition: Rheumatism described as chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures; etiology is unknown, but autoimmune mechanisms have been implicated.\nConcepts: Stimulants, Ganglionic (Parasympathomimetic Agents)\tRHEUMATOID ARTHRITIS (Delayed hypersensitivity disorder)\tJeavons syndrome (Idiopathic generalized epilepsy)\tglycine-inhibited chloride channel activity (inhibitory extracellular ligand-gated ion channel activity)\tPhenomena, Biophysical (Natural Phenomenon or Process)", + "output": "RHEUMATOID ARTHRITIS (Delayed hypersensitivity disorder)" + }, + { + "input": "Definition: regulation of RNA metabolic process described as any process that modulates the frequency, rate or extent of snRNA pseudouridine synthesis.\nConcepts: CSS03-Non-Spec Suicid Thought-P6M (Intellectual Product)\tValue Set (Information Resources)\tregulation of snRNA pseudouridine synthesis (regulation of RNA metabolic process)\t9\u03b1-fluoro-11\u03b2,16\u03b1,17,21-tetrahydroxypregna-1,4-diene-3,20-dione (Steroids, Fluorinated)\tPQL01-Get Sick Easily (Intellectual Product)", + "output": "regulation of snRNA pseudouridine synthesis (regulation of RNA metabolic process)" + }, + { + "input": "Definition: Body Location or Region described as zone of left marginal artery which supplies the apex zone of myocardium of left ventricle and is continuous with zone 16 of left marginal artery.\nConcepts: Artery Scissors (Vascular scissors)\tcopies dna (DNA)\tPachyrhizus (Phaseoleae)\tZone 17 of left marginal artery (Body Location or Region)\tAdrenocorticotropin receptor defect (Finding)", + "output": "Zone 17 of left marginal artery (Body Location or Region)" + }, + { + "input": "Definition: Parametric Statistical Tests described as a statistical test that is used to find out if there is a real difference between the means (averages) of two different groups. It is sometimes used to see if there is a significant difference in response to treatment between groups in a clinical trial.\nConcepts: Lansky Performance Status 10 (Finding)\turease activity (Molecular Function)\tHow often did you feel upset or scared when you had difficulty getting your breath (Intellectual Product)\tResearch Organization Type Code (Type Code)\tt tests (Parametric Test)", + "output": "t tests (Parametric Test)" + }, + { + "input": "Definition: something described as the area under the urinary excretion rate curve (AURC) extrapolated to infinity, based on the last observed excretion rate.\nConcepts: temperament (Personality)\tMETAHEXAMIDE (Organic Chemical)\tAURCIFO (Area Under Urinary Excretion Rate Curve)\tFlame-resistant bed mattress (Bed mattress)\tIVD Test Reagent/Kits, Microbiology, Buffer, Culture Media (IVD Test Reagent/Kits, Microbiology, Buffer)", + "output": "AURCIFO (Area Under Urinary Excretion Rate Curve)" + }, + { + "input": "Definition: Retractor, device described as surgical hooks designed to temporarily secure the skin by catching and/or pulling it during dissection, excision, and/or to perform other surgical procedures with minimal trauma. These surgical hooks typically consist of handheld manual stainless steel instruments curved and with a fine sharp prong at the working end; the hooks typically include a handle at the proximal end. Skin surgical hooks can be supplied double pronged and with a thin and delicate shaft; large skin hooks on long shafts are also available to provide excellent retraction of dense tissue. Skin surgical hooks are used during surgical procedures (e.g., for handling soft tissues) in hospitals, surgery centers, and specialty clinics.\nConcepts: Alarm Failure (Protective Measure Problem)\tstage IB uterine sarcoma (Stage I Uterine Sarcoma AJCC v7)\tSkin hook, device (Retractor, device)\tmania (Mood Disorders)\tUnderachievements (Individual Behavior)", + "output": "Skin hook, device (Retractor, device)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of T-helper cell differentiation.\nConcepts: ANTISERA, FLUORESCENT, ADENOVIRUS 1-33 (Indicator, Reagent, or Diagnostic Aid)\tantisense oligonucleotide therapy (Biological Response Modifier Therapy)\tDer Kaloustian Mcintosh Silver syndrome (Radioulnar Synostosis)\tregulation of T-helper cell differentiation (regulation of immune response)\tCellphone (Telecommunication equipment type)", + "output": "regulation of T-helper cell differentiation (regulation of immune response)" + }, + { + "input": "Definition: Ultracentrifugation described as a high-speed centrifugation-based method that uses an optical detection system to monitor and record data during the centrifugation process.\nConcepts: phlebothrombosis (Venous Thrombosis)\tANALYTICAL ULTRACENTRIFUGATION (Laboratory Procedure)\tAnti-GD2L Antibody (Immunologic Factor)\tGrade 4 Capillary leak syndrome (Finding)\tYale Cancer Center (Health Care Related Organization)", + "output": "ANALYTICAL ULTRACENTRIFUGATION (Laboratory Procedure)" + }, + { + "input": "Definition: Gene or Genome described as human CXCR3 wild-type allele is located within Xq13 and is approximately 3 kb in length. This allele, which encodes C-X-C chemokine receptor type 3 protein, is involved in the recruitment of inflammatory cells and signal transduction.\nConcepts: FACT-C Version 4 - I Am Satisfied With My Sex Life (Intellectual Product)\tIP10-R (CXCR3 gene)\tGrade 2 Cough, CTCAE (Finding)\tRho GDP-dissociation inhibitor binding (Molecular Function)\tGrade 1 Osteonecrosis, CTCAE (Osteonecrosis, CTCAE)", + "output": "IP10-R (CXCR3 gene)" + }, + { + "input": "Definition: transmembrane receptor protein serine/threonine kinase activity described as combining with a member of the bone morphogenetic protein (BMP) family, and transmitting a signal across the plasma membrane to initiate a change in cell activity.\nConcepts: BMP receptor activity (transmembrane receptor protein serine/threonine kinase activity)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Antibiotic, Netilmycin (Medical Device)\tstage 0 medullary thyroid carcinoma in situ (C-cell hyperplasia of thyroid)\tCellular Tropism (Cell Function)\tnegative regulation of sporangium germination on or near host (negative regulation of development of symbiont on or near host surface)", + "output": "BMP receptor activity (transmembrane receptor protein serine/threonine kinase activity)" + }, + { + "input": "Definition: Ion Channel Protein Gene described as this gene is involved in anticoagulation processes and mediates lipid binding.\nConcepts: PLACENTAL PROTEIN 4 (Gene or Genome)\tCadherin Family Member 10 (Receptor)\tVZTAUW (Volume of Distribution for Dosing Interval)\tOromucosal Patch Dosage Form (Oromucosal Dosage Form)\tGNC - Gram-negative coccus (Microorganism)", + "output": "PLACENTAL PROTEIN 4 (Gene or Genome)" + }, + { + "input": "Definition: something described as a semi-aquatic plant used as a vegetable in India.\nConcepts: Enhydra fluctuan (Plant)\tSellar Immature Teratoma (Skull Base Neoplasms)\t50 Percent Cell Culture Infective Dose (Quantitative Concept)\tPelvic fracture NOS-open (Fracture of pelvis)\tChemical and Physical Restraint (Activity)", + "output": "Enhydra fluctuan (Plant)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction.\nConcepts: maintenance of localization (establishment and maintenance of localization)\tregulation of twitch skeletal muscle contraction (regulation of skeletal muscle contraction)\tcoatings tablet (Tablet Dosage Form)\tPotassium Urine Excretion Rate (Excretion Rate)\tFamily canidae (Mammals)", + "output": "regulation of twitch skeletal muscle contraction (regulation of skeletal muscle contraction)" + }, + { + "input": "Definition: Cell Component described as the component of the presynaptic endosome membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.\nConcepts: anchored component of presynaptic endosome membrane (anchored component of membrane)\tFull-Body Pillows (Pillow)\tHerpetiform (Spatial Concept)\tDibromothymolsulfonphthalein (toluene)\tgynecologic services vaginal irrigation (Therapeutic Irrigation)", + "output": "anchored component of presynaptic endosome membrane (anchored component of membrane)" + }, + { + "input": "Definition: Medical Device described as a rigid gas permeable contact lens is a device intended to be worn directly against the cornea of the eye to correct vision conditions. The device is made of various materials, such as cellulose acetate butyrate, polyacrylate-silicone, or silicone elastomers, whose main polymer molecules generally do not absorb or attract water.\nConcepts: Mismatch Repair Protein Proficient (Mismatch Repair Proficient)\tCYP19 Family (Amino Acid, Peptide, or Protein)\tApical anterolateral zone of left marginal artery (Zone of left marginal artery)\tPF03732010 (Antineoplastic Agents)\tLENS, CONTACT (OTHER MATERIAL) - DAILY (Medical Device)", + "output": "LENS, CONTACT (OTHER MATERIAL) - DAILY (Medical Device)" + }, + { + "input": "Definition: Hot Flashes, CTCAE described as severe symptoms; limiting self care ADL\nConcepts: Allantoic Cyst (Pelvic mass)\tADL03-Highest Level of Food Preparation (Intellectual Product)\tAtrioventricular septum (Region of membranous part of interventricular septum)\tGrade 3 Hot flashes (Finding)\tEmery-Dreifuss muscular dystrophy 1 (Disease or Syndrome)", + "output": "Grade 3 Hot flashes (Finding)" + }, + { + "input": "Definition: Skin described as layer of epidermis proper, each instance of which is the layer between some stratum granulosum and stratum basale which consists of some prickle cells.\nConcepts: canonical holin activity (holin activity)\tAFP464 (DNA Adduct Forming Agent)\tprickle cell layer (Body Part, Organ, or Organ Component)\tStage 0 Urethral Cancer (Urethral Cancer by AJCC v7 Stage)\tDigestive functions (Organ or Tissue Function)", + "output": "prickle cell layer (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) Over the past 3 months, I have had wheezing attacks.\nConcepts: Oncology Department (Health care facility)\tOsteolytic defects of the middle phalanx of the 3rd finger (Anatomical Abnormality)\tSGRQ01-I Have Had Wheezing Attacks (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tArabinofuranosyladenine (vidarabine)\tTCAG 1951439 (CREB3L2 gene)", + "output": "SGRQ01-I Have Had Wheezing Attacks (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)" + }, + { + "input": "Definition: Crystallography, X-Ray described as method of deriving phases from measurements of the intensities of the Bragg reflections in the x ray diffraction pattern from two or more isomorphous crystals.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RYR2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tSTAPLE, IMPLANTABLE (Medical Device)\talpha-2BAR (ADRA2B gene)\tPromotional Material Document Type (Classification)\tisomorphous substitution (Laboratory Procedure)", + "output": "isomorphous substitution (Laboratory Procedure)" + }, + { + "input": "Definition: Guanidines described as a guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral resistance and produces fluid retention.\nConcepts: Dyskeratosis congenita syndrome (Disease or Syndrome)\tpositive regulation of motor neuron apoptotic process (Cell Function)\tcentrosomal and pronuclear rotation (cellular developmental process)\tPinacidil (Nucleic Acid, Nucleoside, or Nucleotide)\tpullulan catabolic process (glucan catabolic process)", + "output": "Pinacidil (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Squamous cell carcinoma of tongue described as a low-grade variant of squamous cell carcinoma of the tongue with a warty (verrucous) appearance. []\nConcepts: PSQI - Pittsburgh sleep quality index (Assessment scales)\tVerrucous cell carcinoma of the tongue (Neoplastic Process)\tm-L-sarcolysin (Nitrogen Mustard Antineoplastic Compounds)\tAchromobacter piechaudii (Alcaligenes)\tTrial Shoulder Prostheses (Medical Device)", + "output": "Verrucous cell carcinoma of the tongue (Neoplastic Process)" + }, + { + "input": "Definition: Drowsiness Visual Analogue Scale described as a subjective score of 8 on a drowsiness scale that ranges from 0: No Drowsiness to 10: Worst Possible Drowsiness.\nConcepts: mitotic spindle midzone (spindle midzone)\tLosartan-containing product (Angiotensin II receptor antagonist)\tOral Suspension Dose Form (Oral Dosage Form)\tDrowsiness Score 8 (Drowsiness Visual Analogue Scale)\t1,2,4-trihydroxybenzene:NAD oxidoreductase activity (Molecular Function)", + "output": "Drowsiness Score 8 (Drowsiness Visual Analogue Scale)" + }, + { + "input": "Definition: melphalan described as a mixture of six synthetic oligopeptides, each containing MELPHALAN. It is used as a broad-spectrum antineoplastic due to its alkylating and antimetabolic actions but, is toxic to bone marrow, gastrointestinal system and vasculature.\nConcepts: Peptichemio (Pharmacologic Substance)\tQLES1-Interested in Problems of People (Intellectual Product)\tPlasmid Production (Laboratory Procedure)\tGastric Gastrointestinal Stromal Tumor of Uncertain Malignant Potential (Gastric Precancerous Condition)\t2-Oxazolidinone, 3-(((5-nitro-2-furanyl)methylene)amino)- (Anti-Infective Agents)", + "output": "Peptichemio (Pharmacologic Substance)" + }, + { + "input": "Definition: Qualitative Concept described as the minimum velocity encoded by the phase encoding gradient.\nConcepts: CLPS (Quantitative Concept)\tresponse to ceramide (Cell Function)\tVelocity Encoding Minimum Value (Numerical value)\tFc-gamma receptor signalling pathway involved in phagocytosis (immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)\tClinical Trial Protocols as Topic (Clinical Protocols)", + "output": "Velocity Encoding Minimum Value (Numerical value)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cell surface receptors for ADIPOKINES, cytokines secreted by the ADIPOCYTES.\nConcepts: Sympathetic Ganglion (Sympathetic Nervous System)\tTimers, Apgar Scoring (Medical Device)\tAdipokine Receptors (Amino Acid, Peptide, or Protein)\tPrescriptive Counseling (Counseling)\tbiotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (Molecular Function)", + "output": "Adipokine Receptors (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: negative regulation of ribonucleoprotein complex localization described as any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus.\nConcepts: OPTICAL MAPPING (Molecular Biology Research Technique)\tEmbryonic Developments (Embryology)\tnegative regulation of tRNA export from nucleus (negative regulation of ribonucleoprotein complex localization)\tallogeneic multipotent adult progenitor cells (Non-Tumor Cell Derivative Vaccine)\tSDTM-TSPARM (Intellectual Product)", + "output": "negative regulation of tRNA export from nucleus (negative regulation of ribonucleoprotein complex localization)" + }, + { + "input": "Definition: Fallopian Tube Carcinoma described as a term that refers to the staging of fallopian tube cancer according to the American Joint Committee on Cancer, 8th edition.\nConcepts: negative regulation of eosinophil migration (Cell Function)\tregulation of axillary shoot system formation (Biologic Function)\tCongenital onset (Age of Onset)\tVector-peptide Conjugated Paclitaxel (Pharmacologic Substance)\tFallopian Tube Cancer by AJCC v8 Stage (Neoplastic Process)", + "output": "Fallopian Tube Cancer by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Individual Behavior described as personal actions to understand, prevent, eliminate, or reduce modifiable health threats\nConcepts: cytoplasmic exosome multienzyme ribonuclease complex (Exosome Multienzyme Ribonuclease Complex)\thercynylselenocysteine metabolic process (Molecular Function)\tSCAR16 - spinocerebellar ataxia autosomal recessive type 16 (Disease or Syndrome)\tCDX (Body Substance)\tRisk Control (Individual Behavior)", + "output": "Risk Control (Individual Behavior)" + }, + { + "input": "Definition: Living Arrangement - Institution described as a place that gives care to people who have physical or mental disabilities and need help with activities of daily living (such as taking a bath, getting dressed, and going to the bathroom) but do not need to be in the hospital.\nConcepts: disease pagets vulva (Extramammary Paget's disease of skin)\tcostens syndrome (Mouth and Teeth)\tNidogen 1 Gene (Gene or Genome)\tLong-term care facility (NURSING HOME AND AMBULATORY CARE SITES)\tSGRQ Past 3 Months Version - Breathing Makes Difficult to Do Heavy Manual Work (Intellectual Product)", + "output": "Long-term care facility (NURSING HOME AND AMBULATORY CARE SITES)" + }, + { + "input": "Definition: Urinary Tract Physiology described as increased flow of urine.\nConcepts: presubicular area (Body Location or Region)\tdiuresis (Urinary Tract Physiology)\tCyclophosphamide/Etoposide/Procarbazine/Prednisone Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)\tCostiveness (Comfort Status: Physical)\tirrigation procedure (Therapeutic procedure)", + "output": "diuresis (Urinary Tract Physiology)" + }, + { + "input": "Definition: something described as a question about whether having a hearing problem causes an individual to be nervous.\nConcepts: StudyOutcomeMeasure.timeFrameText (Intellectual Product)\tNasal turbinate bone structure (Nasal cavity)\tDoes a hearing problem cause you to be nervous (Clinical or Research Assessment Question)\tRisk factor (Modifier, linkage term AND/OR qualifier)\tplasma membrane proton-transporting V-type ATPase, V0 domain (Cell Component)", + "output": "Does a hearing problem cause you to be nervous (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Publication Formats described as work consisting of common terms, phrases, idioms, and typical conversations, e.g., between health professional and patients. These are often intended for use by non-native speakers of a language.\nConcepts: Flu (Infectious Lung Disorder)\tPhrase (Intellectual Product)\ttrans-synaptic signaling by soluble gas, modulating synaptic transmission (trans-synaptic signaling, modulating synaptic transmission)\tFACT-C Version 4 - Bothered by Treatment Side Effect (FACT-C Version 4 Questionnaire Question)\tGermicides, Liquid, Glutaraldehyde (Germicides, Liquid)", + "output": "Phrase (Intellectual Product)" + }, + { + "input": "Definition: Anti-Infective Agents described as an aminocoumarin antibiotic, produced by the actinomycete Streptomyces nivens, with antibacterial property. Novobiocin, as well as other aminocoumarin antibiotics, inhibits bacterial DNA synthesis by targeting at the bacteria DNA gyrase and the related enzyme DNA topoisomerase IV. This antibiotic was used to treat infections by gram-positive bacteria.\nConcepts: ADL01-Clear Dishes (ADCS-ADL Questionnaire Question)\tCD158H (Gene or Genome)\tSorbinilum (Aldose Reductase Inhibitor)\tCrystallinic Acid (bactericide)\tUsually (Clinical or Research Assessment Answer)", + "output": "Crystallinic Acid (bactericide)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid preparation consisting of an impregnated plug that generates a vapour to be inhaled, for example by the patient inhaling through a device containing the plug, thereby drawing air through or over it and vaporising the active ingredient(s) impregnated therein.\nConcepts: Inhalation Vapor from Impregnated Plug Dosage Form (Inhalation Vapor Dosage Form)\thistone lysine N-acetyltransferase activity (Molecular Function)\tD-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1-4))-2-deoxy-N1-ethyl- (Antibiotics, Aminoglycoside)\tGenus Trichoderma (Form family Moniliaceae)\tTRDAT (Assessment Date)", + "output": "Inhalation Vapor from Impregnated Plug Dosage Form (Inhalation Vapor Dosage Form)" + }, + { + "input": "Definition: Individual Behavior described as simultaneous task performance, or switching between tasks in a concentrated period of time.\nConcepts: Molecular Diagnosis (Laboratory Procedure)\tBetween Lunch and Dinner (Event related period)\tlobar bronchus epithelium development (lung epithelium development)\tGrayscale Color Map (Intellectual Product)\tMultitasking Behaviors (Behavior)", + "output": "Multitasking Behaviors (Behavior)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question associated with the CHART-SF Paper Version questionnaire.\nConcepts: down regulation of telomere maintenance via recombination (Genetic Function)\tCHART-SF Paper Version Questionnaire Question (Intellectual Product)\tunfocused anxiety (Behavioral/psychiatric manifestations)\tAdrenal Gland Abscess (Abscess)\tDiffuse Midline Glioma, H3 K27M-Mutant (Diffuse Glioma)", + "output": "CHART-SF Paper Version Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: something described as RNA binding protein fox-1 homolog 1 (397 aa, ~43 kDa) is encoded by the human RBFOX1 gene. This protein plays a role in mRNA alternative splicing.\nConcepts: MSAS Physical Symptom Subscale (Intellectual Product)\tRNA Binding Protein Fox-1 Homolog 1 (Amino Acid, Peptide, or Protein)\tallantoin:proton symporter activity (solute:proton symporter activity)\tAbnormal presence of ultra-large von Willebrand factor multimers (Abnormal von Willebrand factor multimer distribution)\tbrain regulatory center (Body Location or Region)", + "output": "RNA Binding Protein Fox-1 Homolog 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Element, Ion, or Isotope described as an element with atomic symbol N, atomic number 7, and atomic weight 14.01.\nConcepts: Amygdalohippocampal area (Body Location or Region)\tvision disorders (Disorder of body system)\tML (Domain)\tN2 - Nitrogen (Medical gases)\tSoftware, Laboratory Fermenter/Bioreactors (Computer software)", + "output": "N2 - Nitrogen (Medical gases)" + }, + { + "input": "Definition: something described as a plant genus of the family Melanthiaceae that is a short plant with a distinct whorl of 3 broad leaves.\nConcepts: LEC01-Captivity: Not Sure (Intellectual Product)\tvulval location (male mating behavior)\tOuter kinetochore of condensed nuclear chromosome (Cell Component)\tprotocol approval (Approved)\ttrillium (Liliaceae)", + "output": "trillium (Liliaceae)" + }, + { + "input": "Definition: Musculoskeletal Diseases described as abnormally increased curvature of the thoracic portion of the spine.\nConcepts: PCBLFL (Baseline Flag)\tExtracellular (Cytology)\tGrade 4 Urinary fistula (Urinary Fistula, CTCAE)\tangulation; spine (orthopedic disorders of spine)\tSurfactant Apoprotein ABCA3 Deficiency (Disease or Syndrome)", + "output": "angulation; spine (orthopedic disorders of spine)" + }, + { + "input": "Definition: something described as a multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.\nConcepts: antibacterial minocycline (Anti-Bacterial Agents)\tSentrin-Specific Protease 1/LDLR Chaperone MESD Fusion Protein (Fusion protein)\tMSG-Related Protein 1 (Amino Acid, Peptide, or Protein)\tCerbera (Plant)\tSoluble Aconitase 1 (Iron-Regulatory Proteins)", + "output": "Soluble Aconitase 1 (Iron-Regulatory Proteins)" + }, + { + "input": "Definition: Inorganic Chemical described as sulphide of antimony.\nConcepts: TINDTP (Intellectual Product)\tMicrowave Therapy Systems, Tissue Ablation, Interstitial (Microwave Therapy Systems, Tissue Ablation)\tAntimonium crudum / antimony sulphide homeopathic preparation (Pharmacologic Substance)\tExhibits as Topic (Audiovisual aids)\tRCAMIFOW (Amount Recovered Infinity Observed)", + "output": "Antimonium crudum / antimony sulphide homeopathic preparation (Pharmacologic Substance)" + }, + { + "input": "Definition: Completion Status described as a term used to describe the state or condition of the completeness of the morphology data.\nConcepts: Morphology Completion Status (Completion Status)\tup regulation of regulation of translation initiation by eIF2alpha dephosphorylation in response to endoplasmic reticulum stress (positive regulation of response to endoplasmic reticulum stress)\tAdrenal Cancer pM1 TNM Finding v7 (Adrenal Cancer Pathologic Distant Metastasis TNM Finding v7)\tAcid, Peroxyacetic (Organic Chemical)\tSoftware, Speech Recognition (Computer software)", + "output": "Morphology Completion Status (Completion Status)" + }, + { + "input": "Definition: Auriculotemporal part of head described as a cytoarchitecturally defined portion of the cerebral cortex. It occupies most of the temporal lobe. It is composed of the area 52 of Brodmann (human), the area 41 of Brodmann (human), the area 42 of Brodmann (human), the area 22 of Brodmann (human), the area 21 of Brodmann (human), the area 20 of Brodmann (human), the area 36 of Brodmann (human), the area 37 of Brodmann (human) and the area 38 of Brodmann (human) ( Brodmann-1909 ).\nConcepts: Angiotensin-1, human (Biologically Active Substance)\tSpasmodic dysphonia (Disorder of skeletal muscle)\tQS-GOSE TESTCD (Intellectual Product)\tTemporal region (Surface region of head)\tDRP1 protein, human (Enzyme)", + "output": "Temporal region (Surface region of head)" + }, + { + "input": "Definition: something described as a question associated with the FACIT-Dyspnea 10 Item Short Form questionnaire.\nConcepts: FACIT-Dyspnea 10 Item Short Form Questionnaire Question (Intellectual Product)\tNP 005219.2:p.G719X (EGFR Protein Variant)\tcarbon nitrogen ligase (Ligase)\tbenzoyl-CoA metabolism (acyl-CoA metabolic process)\tStructure of lymphatic system (Lymphoid system structure)", + "output": "FACIT-Dyspnea 10 Item Short Form Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: hexadecanal metabolic process described as the chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde.\nConcepts: Pediatric Immunization Terminology (NICHD Terminology)\tUDPglucose:gibberellin 2-O-beta-D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)\tPosture mirror (Mirror)\thexadecanal formation (aldehyde biosynthetic process)\tgenetic inversion (Alteration of chromosome structure)", + "output": "hexadecanal formation (aldehyde biosynthetic process)" + }, + { + "input": "Definition: something described as sue associated with failure of device to discharge its load (e.g., surgical stapler failed to partially or completely deploy its staples).\nConcepts: tRNA seleno-modification (selenium compound metabolic process)\tGNA12 (Heterotrimeric G Protein Subunit Gene)\tMisfire (Medical Device Mechanical Issue)\tlight transducer activity (energy transducer activity)\tTorsiometers (Medical Device)", + "output": "Misfire (Medical Device Mechanical Issue)" + }, + { + "input": "Definition: Laboratory Procedure described as a functional measurement of the ability of serum complement proteins to lyse target cells via classical activation that measures function of all complement components C1-C9. The CH50 is the reciprocal of the dilution of serum that induces lysis of 50% of target cells in a standardized assay.\nConcepts: lipoyl-X-hydrolase (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tEssential (Qualitative Concept)\tIVD Test Reagent/Kits, Immunoassay, Immunology, Tissue Typing (IVD Test Reagent/Kits, Immunoassay, Immunology)\tCH>50< assay (Assay)\tTC-210 (Antineoplastic Immune Cell)", + "output": "CH>50< assay (Assay)" + }, + { + "input": "Definition: Flavoproteins described as a flavoprotein enzyme that catalyzes the formation of acetolactate from 2 moles of PYRUVATE in the biosynthesis of VALINE and the formation of acetohydroxybutyrate from pyruvate and alpha-ketobutyrate in the biosynthesis of ISOLEUCINE. This enzyme was formerly listed as EC 4.1.3.18.\nConcepts: Acid Synthetase, Acetohydroxy (Lyase)\tExpiratory Forced Flow Rates (Finding)\tTREX2 wt Allele (Gene or Genome)\tBenign Tumor of the Germ Cell (Benign Neoplasm)\tDorsal grey horn (Neuroanatomy)", + "output": "Acid Synthetase, Acetohydroxy (Lyase)" + }, + { + "input": "Definition: Neoplastic Process described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).\nConcepts: breast; intraductal papillary carcinoma (In situ neoplasm)\tcontiguous stage II grade 1 follicular lymphoma (Ann Arbor Stage II Grade 1 Follicular Lymphoma)\tResource Type Code (Type Code)\tComprehending simple spoken messages (Communicating with - receiving - spoken messages)\tactivin responsive factor complex location (RNA polymerase II transcription regulator complex)", + "output": "contiguous stage II grade 1 follicular lymphoma (Ann Arbor Stage II Grade 1 Follicular Lymphoma)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to anterior horn cells or to the white matter ascending and descending longitudinal fibers.\nConcepts: Arcibacter cryaerophilus (Campylobacter)\tCarbohydrate deficient glycoprotein syndrome type IIe (Congenital disorder of glycosylation type 2A)\tIs Paraneoplastic Syndrome Present (CPTAC Questions)\tDorsal Horn Cell (Spinal Cord)\tClasps, Denture (Dental Attachments)", + "output": "Dorsal Horn Cell (Spinal Cord)" + }, + { + "input": "Definition: something described as trypsin-2 (247 aa, ~26 kDa) is encoded by the human PRSS2 gene. This protein is involved in the catabolism of proteins in the small intestine.\nConcepts: Trypsinogen 2 (Amino Acid, Peptide, or Protein)\tAbnormal emotion/affect behavior (Abnormal behavior)\t3-hydroxyphenylacetate catabolic process (3-hydroxyphenylacetate metabolic process)\tRecombinant 7 (Murine leukemia virus)\t5'-Guanylic acid (Biologically Active Substance)", + "output": "Trypsinogen 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a question about other notable events that happened during surgery.\nConcepts: Grade 3 Somnolence (Finding)\tUndef phone consult (Therapeutic or Preventive Procedure)\tOther Notable Events During Surgery (CPTAC Questions)\tCapras (Ruminants)\tGrade 4 Hepatic necrosis (Finding)", + "output": "Other Notable Events During Surgery (CPTAC Questions)" + }, + { + "input": "Definition: Volume of Distribution for Dosing Interval described as the volume of distribution associated with the terminal slope following intravascular administration, calculated using AUCTAU, divided by the weight.\nConcepts: VZTAUW (Volume of Distribution for Dosing Interval)\tIU/ml (IU per unit volume)\tSNS01-T nanoparticles (Antineoplastic Biological Agent)\tInformation Systems, Telemedicine, Ophthalmology (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DSC2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "VZTAUW (Volume of Distribution for Dosing Interval)" + }, + { + "input": "Definition: Professional or Occupational Group described as an individual who provides supervision, socialization, and non-medical care to a functionally impaired adult. Companions may assist or supervise the individual with such tasks as meal preparation, laundry and shopping, but do not perform these activities as discrete services. These services are provided in accordance with a therapeutic goal in the plan of care.\nConcepts: Nursing Service Related Providers; Adult Companion (Professional or Occupational Group)\tPersonal Autonomy (Psychological Phenomena)\tECADJ (Dose Adjustment Reason)\tCavopulmonary Shunt (Vascular Grafting)\tPurposely Unmarried and Sexually Abstinent (Currently not sexually active)", + "output": "Nursing Service Related Providers; Adult Companion (Professional or Occupational Group)" + }, + { + "input": "Definition: Vaginal septum described as the presence of a vaginal septum, thereby creating a vaginal duplication. The septum is longitudinal in the majority of cases.\nConcepts: codeine O-demethylase activity (Molecular Function)\tSeptate vagina NOS (CONGENITAL ANOMALIES OF THE VAGINA AND VULVA)\tadenomas kidney (Neoplastic Process)\tfissuring (Mechanical abnormality)\tPSA (Publication Formats)", + "output": "Septate vagina NOS (CONGENITAL ANOMALIES OF THE VAGINA AND VULVA)" + }, + { + "input": "Definition: something described as left anterior fascicular block is characterized by all of the following: Left-axis deviation with frontal QRS axis between 45\u00b0 and 90\u00b0; Q wave in lead aVL; rS in inferior leads; QRS duration is 120 ms.\nConcepts: Electrocardiogram: left anterior fascicular block (Heart Block by ECG Finding)\tsuperior temporal sulcus main body (Body Space or Junction)\tpositive regulation of gamma-delta T lymphocyte activation (positive regulation of T cell activation)\tintrinsic component of plasma membrane of cell tip (intrinsic component of plasma membrane)\tWD3-Your Day-to-Day Work/School (WHODAS 2.0 12-item Version Self-administered Questionnaire Question)", + "output": "Electrocardiogram: left anterior fascicular block (Heart Block by ECG Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in spermatogenesis or spermiogenesis.\nConcepts: CSS0320 (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tTestis Specific Serine Kinase Substrate Gene (Gene or Genome)\tMicrotubule associated tau protein (Microtubule-Associated Proteins)\tsteroid 5alpha-reductase (Molecular Function)\tGastroscopes, Flexible, Video (Medical Device)", + "output": "Testis Specific Serine Kinase Substrate Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as mucosal melanoma of the head and neck with regional lymph node metastases.\nConcepts: negative regulation of TLR13 signaling pathway (regulation of toll-like receptor 13 signaling pathway)\tStudy procedures (Protocol Deviation)\tlongitudinal axis specification (embryonic axis specification)\tMurine Leukemia Virus MLV (Mammalian group, replication competent Gammaretroviruses)\tMucosal Melanoma of the Head and Neck pN1 TNM Finding v7 (Mucosal Melanoma of the Head and Neck Pathologic Regional Lymph Nodes TNM Finding v7)", + "output": "Mucosal Melanoma of the Head and Neck pN1 TNM Finding v7 (Mucosal Melanoma of the Head and Neck Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: Domestic Sheep described as merino sheep breed group\nConcepts: Wide Column of Contrast or Air Between Tongue Base and Posterior Pharyngeal Wall During Swallowing (Finding)\tnegative regulation of leaf senescence (regulation of leaf senescence)\tEORTC QLQ-C30 Version 3 - Did You Feel Depressed (Intellectual Product)\tCirculatory Precautions (Therapeutic or Preventive Procedure)\tMerino superbreed (Domestic Sheep)", + "output": "Merino superbreed (Domestic Sheep)" + }, + { + "input": "Definition: something described as disorders of the special senses (i.e., VISION; HEARING; TASTE; and SMELL) or somatosensory system (i.e., afferent components of the PERIPHERAL NERVOUS SYSTEM).\nConcepts: sensation disorder (Neurologic Manifestations)\tAdministratively Withdrawn (Functional Concept)\tLuteal cystic ovary disease (Benign cyst of ovary)\tasymmetric stem cell division (Stem Cell Self-Renewal)\tCedar, Red Eastern (Plant)", + "output": "sensation disorder (Neurologic Manifestations)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of the NKX2.1 transcription factor present in a sample.\nConcepts: cntmn8d mat disposal edkshn (Patient counseling education)\tTrue Histiocytic Lymphomas (Malignant Neoplasms)\tComfortable/at ease during sexual activity (Intellectual Product)\tNKX2.1 Measurement (Laboratory Procedure)\tRegulators, Suction, Low-Volume (Suction regulator)", + "output": "NKX2.1 Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a heterotrimeric protein complex composed of 110 kDa elongin A, 18 kDa elongin B, and 15 kDa elongin C subunits. It functions as a positive regulator of RNA POLYMERASE II, increasing its rate of transcriptional elongation by suppressing transient pausing along the DNA template. Elongin A is the transcriptionally active component; elongins B and C enhance its activity.\nConcepts: SLC9A9 Gene (Gene or Genome)\tNPY5R wt Allele (Gene or Genome)\tSIII, Transcription Factor (DNA-Binding Proteins)\tQIDSR113 (QIDS-SR Questionnaire Question)\tLAPAROSCOPE, GYNECOLOGIC (Medical Device)", + "output": "SIII, Transcription Factor (DNA-Binding Proteins)" + }, + { + "input": "Definition: Cell Function described as the directed movement of a motile cell or organism towards the source of gravity.\nConcepts: MR - Mental retardation (Special Education)\tcentral B-cell anergy (Biologic Function)\tpositive geotactic behavior (Cell Function)\tVertebral artery hypoplasia (Disease or Syndrome)\tfracture-dislocation (Dislocations)", + "output": "positive geotactic behavior (Cell Function)" + }, + { + "input": "Definition: something described as muscle strength exercisers designed to provide resistance to contraction of any major body muscle group using equipment based on a system of pulleys and cables, or levers. These exercisers usually consist of a stand-alone machine with weights stacked on top of each other, a system to transmit the force (i.e., to convey resistance), and lever bars or pulley cables on which the user exerts force to counteract the exerciser resistance. Pulley-cable full-body exercisers usually contain low cables with adjustable positions to train the upper body, trunk, and lower body. Full-body strength exercisers are intended to improve muscle strength in the entire body (arm, chest, back, abdomen, leg); they may also increase muscle size, muscle endurance, and power and improve bone density.\nConcepts: Increase or decrease in thiamin content of the diet. Treament for prevention of beriberi. (Source: Dietary Reference Intakes: Vitamins; USDA Food and Nutrition Center). (Therapeutic or Preventive Procedure)\tapical constriction (actin-mediated cell contraction)\tExercisers, Muscle Strength, Lever/Pulley-Cable, Full Body (Manufactured Object)\tDeleterious RAD25 Gene Mutation (Cell or Molecular Dysfunction)\tBotulin Pathway (Infectious Disease Pathway)", + "output": "Exercisers, Muscle Strength, Lever/Pulley-Cable, Full Body (Manufactured Object)" + }, + { + "input": "Definition: Lesion Identification described as the identification of a tumor that is incapable of being measured at baseline.\nConcepts: SCA7 Protein (Biologically Active Substance)\t7p13 (Cell Component)\tMild malformation of cortical development (Cortical Dysplasia)\tQuality of Life Questionnaire - Pancreatic Cancer 26 (Symptom Specific Assessment Tool)\tNon-Measurable Tumor Identification (Lesion Identification)", + "output": "Non-Measurable Tumor Identification (Lesion Identification)" + }, + { + "input": "Definition: something described as a traditional unit of linear measurement equal to one-millionth of an inch.\nConcepts: uin (Unit of length)\tundef.nrse new inofc W nrsng (Health Care Activity)\tEstrogen-Related Receptor Alpha wt Allele (ESRRA gene)\tVITAMIN B12 DEFICIENCY (Abnormal vitamin B12 level)\tStage I Nasopharyngeal Carcinoma (Nasopharyngeal Carcinoma by AJCC v6 Stage)", + "output": "uin (Unit of length)" + }, + { + "input": "Definition: Occupational Activity described as the use of a radiation monitoring device composed of material which emits light after being illuminated. The amount of light emitted is proportional to the amount of IONIZING RADIATION to which the material has been previously exposed.\nConcepts: ADNI AVLT - List A Recall 1 Word 8 (Intellectual Product)\tPHENYL ACETATE (Toxins and poisons)\tDrug Delivery Balloon Coronary Angioplasty Catheters (Coronary angioplasty balloon catheter)\tOptically Stimulated Luminescence Dosimetry (Occupational Activity)\tParathyroid Carcinoma pTis TNM Finding v8 (Parathyroid Carcinoma Pathologic Primary Tumor TNM Finding v8)", + "output": "Optically Stimulated Luminescence Dosimetry (Occupational Activity)" + }, + { + "input": "Definition: Head finding described as unclear or indistinct sight.\nConcepts: Blurry vision (Clarity of visual image - finding)\tHave you been physically limited as a result of your disease or treatment (Intellectual Product)\tGastroesophageal Junction (Zone of continuity)\tMaternal (Family Group)\t1-AGP Acyltransferase 9 (Acyltransferase)", + "output": "Blurry vision (Clarity of visual image - finding)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic, soluble prodrug of beta-lapachone, a poorly soluble, ortho-naphthoquinone with potential antineoplastic and radiosensitizing activity. ARQ 761 is converted to beta-lapachone (b-lap) in vivo. When b-lap is activated by NAD(P)H:quinone oxidoreductase-1 (NQO1) this agent creates a futile oxidoreduction, generating highly reactive oxygen species (ROS) that results in DNA damage. The activation of b-lap also causes hyperactivation of poly (ADP-ribose) polymerase-1 (PARP-1), an enzyme that facilitates DNA repair, accompanied by rapid depletion of NAD+/ATP nucleotide levels. As a result, a caspase-independent and endoplasmic reticulum (ER) stress-induced mu-calpain-mediated cell death occurs in NQO1-overexpressing tumor cells. In addition, b-lap induces expression of the checkpoints activator E2F transcription factor 1 (E2F1) and thereby activates the E2F1-mediated checkpoint pathway that directly triggers apoptosis. As ARQ 761 is soluble and requires less solvent, this formulation may cause less hemolytic anemia associated with administration of the synthetic b-lap ARQ 501. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99146\" active clinical trials using this agent.\nConcepts: TGF-beta-2 (T [Preparations])\tbeta-lapachone prodrug ARQ 761 (Antineoplastic Agents)\tParotidinum / mumps nosode (Homeopathic remedies letter P)\tvulvar discomfort (Perineal finding)\tEfferent Nerve (Neurons)", + "output": "beta-lapachone prodrug ARQ 761 (Antineoplastic Agents)" + }, + { + "input": "Definition: Intercellular Communication Process described as the communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.\nConcepts: Synaptic transmission, NOS (Nerve cell and nerve fiber function)\thippocampus major (Brain part)\tcondensed chromatin of inactivated sex chromosome (Cell Component)\tGoiters, Intrathoracic (Disease or Syndrome)\thydrogenase activity (oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor)", + "output": "Synaptic transmission, NOS (Nerve cell and nerve fiber function)" + }, + { + "input": "Definition: something described as a process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment.\nConcepts: protein localisation to photoreceptor outer segment (protein localization to non-motile cilium)\tSponsor Reference Identifier (Reference ID)\tnew hm visit 25min (Remote location new client without ICD diagnosis)\tAF6 (Cytoskeletal Proteins)\tTwo-vessel cord (cord number of vessels)", + "output": "protein localisation to photoreceptor outer segment (protein localization to non-motile cilium)" + }, + { + "input": "Definition: Genetic Diseases, X-Linked described as a rare chromosomal anomaly syndrome resulting from the partial duplication of the long arm of chromosome X, characterised by global developmental delay, autistic behaviour, microcephaly and facial dysmorphism (including down-slanting palpebral fissures, depressed nasal bridge, anteverted nares, long philtrum, down-slanting corners of the mouth). Seizures have also been reported in some patients.\nConcepts: Structure of superior frontal sulcus (Cerebral dorsum structure)\tNeoplasm of Adult Cerebellum (Neoplastic Process)\tangioedema (Skin and subcutaneous tissue disorders)\tSGRQ01-Unpleasant Side Effect From Med (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tXq12-q13.3 duplication syndrome (Disease or Syndrome)", + "output": "Xq12-q13.3 duplication syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: RNA Degradation described as the chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA).\nConcepts: Lower vermilion height (Fiat anatomical line of head)\tRaccoon Dog (Mammal)\tIRB/IEC Report (Intellectual Product)\tIntraosseous Injection Needles (NEEDLES,INJECTION)\tpre-mRNA catabolic process (Genetic Function)", + "output": "pre-mRNA catabolic process (Genetic Function)" + }, + { + "input": "Definition: Genetic finding described as individual, strain, or species genetic variation resulting from an abrupt or unusual change in gene structure. Also, an externally induced or naturally occurring change in gene characteristics that is propagated in subsequent divisions of the cell.\nConcepts: Fosquidone (Pharmacologic Substance)\tINFECT RETROVIRUS (Retroviridae Infections)\tmutations (Variation)\tSHELTER HOMELESS (Place of Service Codes for Professional Claims)\tAbnormality of neutrophil physiology (Neutrophil abnormality)", + "output": "mutations (Variation)" + }, + { + "input": "Definition: Imaging Technology described as the process by which an image is acquired by recording light emissions.\nConcepts: Photographies (Investigative Techniques)\tChromosome 19 Open Reading Frame 17 Gene (ELL gene)\tPatient receives consistent and comparable care regardless of the setting (Finding related to care delivery)\tL/h/ng (Quantitative Concept)\tGrade 3 or 4 Elevation of AST, ALT, and/or Bilirubin (Liver function tests abnormal finding)", + "output": "Photographies (Investigative Techniques)" + }, + { + "input": "Definition: something described as criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. (Blade J, Samson D, Reece D, Apperley J, Bjorkstrand B, Gahrton G, Gertz M, Giralt S, Jagannath S, Vesole D. Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant. Br J Haematol. 1998 Sep;102(5):1115-23.)\nConcepts: Non-IP Documentation of Return (Intellectual Product)\tPx - Plasma exchange (Extracorporeal Circulation)\tEBMT Blade Myeloma 1998 Oncology Response Criteria (Intellectual Product)\treelin protein, human (Enzyme)\tLaryngeal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)", + "output": "EBMT Blade Myeloma 1998 Oncology Response Criteria (Intellectual Product)" + }, + { + "input": "Definition: Rat Histopathology Diagnoses for Proliferative Changes described as disorders of the rat that are characterized by cell proliferation, organized by body location.\nConcepts: Rat Proliferative Change by Location (Classification)\tReview of major housing adaptation plan (Health Care Activity)\tviral RNA genome packaging (Cell Function)\tPROTOTHECA ZOPFII (Algae)\tIsotope, Radioactive (ELEMENTS AND BASIC CHEMICAL COMPOUNDS)", + "output": "Rat Proliferative Change by Location (Classification)" + }, + { + "input": "Definition: something described as an analysis of all of the microRNA molecules expressed in a biological sample.\nConcepts: MicroRNA Expression Profile (Molecular Profiling)\tFamily Received Employment Insurance (Intellectual Product)\tTRECOVIRSEN (Mixed-Backbone Oligonucleotide)\tInulin clearance test (Kidney Function Tests)\tCervical Atypical Polypoid Adenomyoma (Cervical Adenomyoma)", + "output": "MicroRNA Expression Profile (Molecular Profiling)" + }, + { + "input": "Definition: Finding described as an indication that the results from radiographic and pathological testing do not correlate.\nConcepts: uridine diphosphoglucose-nuatigenin glucosyltransferase activity (Molecular Function)\tRadiographic Image Not Correlated with Tumor Pathology Finding (Status of correlation between radiographic image and pathologic finding)\tPedsQL Neuromuscular Module Version 3.0 Young Child Report (Intellectual Product)\tRecombinant Heparin Binding Neurite-promoting Factor (Amino Acid, Peptide, or Protein)\tPosterior Cerebellar Commissures (Body Space or Junction)", + "output": "Radiographic Image Not Correlated with Tumor Pathology Finding (Status of correlation between radiographic image and pathologic finding)" + }, + { + "input": "Definition: something described as a first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activities. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption.\nConcepts: Skin Melanoma pNX TNM Finding v7 (Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v7)\tHMO (Treatment Facilities)\tregulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine (Organism Function)\tAcido clodronico (Antiresorptive Agents)\tferrum picricum/iron picrate (Homeopathic remedies letter F)", + "output": "Acido clodronico (Antiresorptive Agents)" + }, + { + "input": "Definition: something described as a form-genus of spherical to rod-shaped CYANOBACTERIA in the order Chroococcales. They contain THYLAKOIDS and are found in a wide range of habitats.\nConcepts: Anacystis (Synechococcaceae)\tPostal (Functional Concept)\tdrying (Chemistry Techniques, Analytical)\tAbnormal 4th finger phalanx morphology (Abnormal finger phalanx morphology)\tPulmonary Interstitial Emphysema (Cyst)", + "output": "Anacystis (Synechococcaceae)" + }, + { + "input": "Definition: Eukaryote described as an order of parasitic organisms in the class COCCIDIA. Families include CRYPTOSPORIDIIDAE; EIMERIIDAE; and SARCOCYSTIDAE.\nConcepts: ANTIGEN, B. PARAPERTUSSIS (Indicator, Reagent, or Diagnostic Aid)\tcarbohydrate export (Cell Function)\tLIQUID CHROMATOGRAPHY, DIPHENYLHYDANTOIN (Medical Device)\tPelvic, Specify (CPTAC Questions)\tEimeriida (Eukaryote)", + "output": "Eimeriida (Eukaryote)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - I am satisfied with family communication about my illness.\nConcepts: CATHETER, HEMODIALYSIS, IMPLANTED (Medical Device)\tFAC061-Satisfied Communication Illness (FACT-BMT Version 4 Questionnaire Question)\tTissue Scaffolds (Biomedical or Dental Material)\tIVD Test Reagent/Kits, Immunoassay, Bone Metabolism Marker, Osteocalcin (IVD Test Reagent/Kits, Immunoassay, Bone Metabolism Marker)\tcalcium undecylenate (SKIN AND MUCOUS MEMBRANE ANTIFUNGAL AGENTS)", + "output": "FAC061-Satisfied Communication Illness (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as the probability of a tracer molecule being retained in a tissue once it has entered via the bloodstream. It can be calculated by: (tracer remaining in a tissue) / (total tracer that entered on a single passage of tracer-carrying blood through it).\nConcepts: SPECTACLE MICROSCOPE, LOW-VISION (Medical Device)\t13: 49554115-49515574 (Spatial Concept)\tMIR521-2 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tTracer Extraction Fraction (Quantity fraction)\tPartial duplication of the innermost bone of the ring finger (Partial duplication of the proximal phalanges of the hand)", + "output": "Tracer Extraction Fraction (Quantity fraction)" + }, + { + "input": "Definition: something described as the process of creating a summary of the main points of an article, argument, or theory.\nConcepts: Follitropin (Luteinizing hormone/follicle stimulating hormone measurement)\tCharcot-Marie-Tooth Neuropathy, Type 4e (Charcot-Marie-Tooth disease type 4)\tUterine Ligament Endometrioid Adenocarcinoma (Adenocarcinoma, Endometrioid)\tPancreatico-Duodenal Vein (Structure of pancreatic vein)\tAbstract (Action)", + "output": "Abstract (Action)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cancer vaccine made with a form of a chicken virus that does not cause disease in humans. It is being studied in the treatment of some types of cancer. The virus is changed in the laboratory to make human proteins that may help immune cells in the body kill tumor cells.\nConcepts: cyclic AMP metabolism (purine ribonucleotide metabolic process)\trhodium oxydatum nitricum/rh (Pharmacologic Substance)\tfCEA-MUC-1-TRI (Pharmacologic Substance)\tBreast Hamartoma (Non-Neoplastic Breast Disorder)\tVestibular gland (Vestibular gland structure)", + "output": "fCEA-MUC-1-TRI (Pharmacologic Substance)" + }, + { + "input": "Definition: Triage described as establishing the nature and urgency of a health problem over the phone to provide direction for course of action, narrative required.\nConcepts: Genital Examination - External Genitalia (examination of genitalia)\tphagocytose (vesicle-mediated transport)\tphn triage narr req'd (Health Care Activity)\tStructure of vertebral vein (Structure of vein of neck)\tGluten-free DHA/EPA/GLA/Antioxidant-rich Nutritional Liquid (Food)", + "output": "phn triage narr req'd (Health Care Activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as antibodies reactive with the HTLV-I ANTIGENS.\nConcepts: Orbitalis (Skeletal muscle structure of head)\tAnti-HTLV-1Antibody (Immunologic Factor)\tGDS0208 (Intellectual Product)\tSize perception (Perception)\tBeta 2-microglobulinuria (Abnormal urine protein level)", + "output": "Anti-HTLV-1Antibody (Immunologic Factor)" + }, + { + "input": "Definition: Chronic myeloid leukemia - category described as a chronic myeloproliferative neoplasm characterized by the expression of the BCR-ABL1 fusion gene. It presents with neutrophilic leukocytosis. It can appear at any age, but it mostly affects middle aged and older individuals. Patients usually present with fatigue, weight loss, anemia, night sweats, and splenomegaly. If untreated, it follows a biphasic or triphasic natural course; an initial indolent chronic phase which is followed by an accelerated phase, a blast phase, or both. Allogeneic stem cell transplantation and tyrosine kinase inhibitors delay disease progression and prolong overall survival.\nConcepts: chronic myelogenous leukemia - BCR/ABL positive (Primary malignant neoplasm)\tOculocutaneous Albinism Gene Mutation Panel Reagents (Medical Device)\tWolffian Duct Cell (Embryonic Cell)\tExtra spleen (Abnormal spleen morphology)\tintercalator (DNA Binding Agent)", + "output": "chronic myelogenous leukemia - BCR/ABL positive (Primary malignant neoplasm)" + }, + { + "input": "Definition: something described as any process that alters the size or shape of an auditory receptor cell.\nConcepts: MSQL126 (Intellectual Product)\tauditory receptor cell morphogenesis (Cell Function)\ttrans-methoxy-C60-meroacyl-AMP ligase activity (acid-thiol ligase activity)\tTFIIE-class transcription factor binding (RNA polymerase II general transcription initiation factor binding)\tPolyclonal elevation of circulating IgG (Increased circulating IgG level)", + "output": "auditory receptor cell morphogenesis (Cell Function)" + }, + { + "input": "Definition: Hematology described as the presence of erythrocytes with a mouth-shaped (stoma) area of central pallor on peripheral blood smear.\nConcepts: Tumor Necrosis Factor Family Protein (Recombinant Cytokines)\tNPI1-Lost Interest in Friends (Intellectual Product)\tsubtilis bacillus (B [Preparations])\terythrocyte stomatocytes (Laboratory or Test Result)\tAuditory Psychophysics (Biomedical Occupation or Discipline)", + "output": "erythrocyte stomatocytes (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as a plant genus of the family RUBIACEAE. The root is a source of red dyes (madder color and 1,2,4-trihydroxy-9,10-anthracenedione) and ANTHRAQUINONES.\nConcepts: Rubia, NOS (Rubiaceae)\tCatheters, Cardiac, Flotation Balloon, Pacing Electrode (Cardiac balloon catheter)\tUHDRS 1999 Version - Hallucinations: Frequency (Intellectual Product)\tDiabetic embryopathy (Disorder of fetal structure)\tInotropic Agents, Positive Cardiac (Inotropic agent)", + "output": "Rubia, NOS (Rubiaceae)" + }, + { + "input": "Definition: Neoplastic Process described as a Kaposi sarcoma arising from the rectum.\nConcepts: ET-BR (G-Protein-Coupled Receptors)\tMismatch Repair, DNA (Genetic Function)\tRectal Kaposi Sarcoma (sarcoma of rectum)\tDermatoses, Scalp (Disease or Syndrome)\tPowder and Solvent for Oral Suspension Dosage Form (Biomedical or Dental Material)", + "output": "Rectal Kaposi Sarcoma (sarcoma of rectum)" + }, + { + "input": "Definition: Disease or Syndrome described as cyst on the surface of the placenta consisting of amnion and chorion.\nConcepts: casanthranol (Anthraquinones)\tvanadium-iron nitrogenase complex location (Cell Component)\tCapillaries (Body Part, Organ, or Organ Component)\tchromoshadow domain binding (Molecular Function)\tSubchorionic septal cyst (Anomaly of placenta)", + "output": "Subchorionic septal cyst (Anomaly of placenta)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of sarcoma of the orbit, following the rules of the TNM AJCC v7 classification system. The nature of the histopathology specimen (fine-needle aspiration biopsy, excisional biopsy, lumpectomy, or total excision) should be noted. Pathologic classification is based on the specific histopathology of the tumor, its differentiation (grade), and the extent of removal (evaluation of the excisional margins). In total excision specimens, evaluation of the surgical margins is mandatory.\nConcepts: Non-Recurrent Lung Carcinoma (Neoplastic Process)\tupregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (positive regulation of intracellular protein transport)\tregulation of mitotic spindle pole body separation (Cell Function)\tFenestrometers (Measuring Instruments, Sensorial)\tSarcoma of the Orbit Pathologic TNM Finding v7 (Finding)", + "output": "Sarcoma of the Orbit Pathologic TNM Finding v7 (Finding)" + }, + { + "input": "Definition: A [Preparations] described as the essential oil of Achillea millefolium, the yarrow plant. Yarrow oil has activities that can be beneficial to the nervous, genitourinary and digestive systems, and can be used topically for skin care.\nConcepts: Small cell carcinoma, intermediate cell (Neoplastic Process)\tdentatoreticular tract (Body Part, Organ, or Organ Component)\tAbsence of acoustic reflex (Finding)\tSwiss Webster Mouse (Mammal)\tYarrow Oil (Organic Chemical)", + "output": "Yarrow Oil (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as a device identifier for the package configuration that contains multiple units of the base package (does not include shipping packages).\nConcepts: Nervonic acid (Organic acid and organic acid derivative)\tFatigue Interference Score 6 (Intellectual Product)\tPrimary Package Identifier (Primary Identifier)\tVEIN, CEPHALIC (Veins)\tgallium(Ga) (Metals)", + "output": "Primary Package Identifier (Primary Identifier)" + }, + { + "input": "Definition: something described as a modification to the solid 7H10 growth medium that is enriched by the addition of an enzymatic digest of casein.\nConcepts: Origin Recognition Complex Subunit 1-Like (Biologically Active Substance)\tMiddlebrook 7H11 agar (Indicator, Reagent, or Diagnostic Aid)\tuntreated primitive neuroectodermal tumor, supratentorial, childhood (Childhood Supratentorial Embryonal Tumor, Not Otherwise Specified)\tNP 004963.1:p.E985K (Cell or Molecular Dysfunction)\tCytokeratin 6 (Keratins, Type II)", + "output": "Middlebrook 7H11 agar (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a person who has never smoked at the time of the interview or has smoked less than 100 cigarettes in their life.\nConcepts: Grade 3 Neonatal Sinus Tachycardia, AE (Finding)\tstamen morphogenesis (Biologic Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, F13B (Medical Device)\tNever Smoked (Smoking Status)\tVitreous inflammatory cells (Finding)", + "output": "Never Smoked (Smoking Status)" + }, + { + "input": "Definition: Atrophy/Degeneration affecting the central nervous system described as loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells.\nConcepts: CTImagingAcquisitionProtocolElement.spiralPitchFactor (Quantitative Concept)\tReplication Protein A 32 kDa Subunit (Enzyme)\tSPERM, DECREASED (Male Reproductive System Finding)\tCalcineurin Binding Protein 1 Gene (Gene or Genome)\tdegeneration nerves (nervous system disorder)", + "output": "degeneration nerves (nervous system disorder)" + }, + { + "input": "Definition: positive regulation of phosphorylation described as any process that activates or increases the frequency, rate or extent of oxidative phosphorylation.\nConcepts: cleavage furrow contraction (plasma membrane invagination)\tLIN-28 (Translation Process Gene)\tupregulation of oxidative phosphorylation (positive regulation of ATP metabolic process)\tMiT Family Translocation (Chromosomal translocation)\tCytokine-cytokine receptor interaction (Functional Concept)", + "output": "upregulation of oxidative phosphorylation (positive regulation of ATP metabolic process)" + }, + { + "input": "Definition: Substance with etiopathic disposition mechanism of action described as drugs or other agents that cause developmental malformations.\nConcepts: dendritic spine membrane (neuron projection membrane)\tTeratogenic substance (Substance categorized by disposition)\tzymogen granule membrane (Cell Component)\tChambers, Laboratory, Microarray Hybridization (Medical Device)\tObtuse angle of mandible (Skull)", + "output": "Teratogenic substance (Substance categorized by disposition)" + }, + { + "input": "Definition: Electrolyte and Acid-Base Management described as promotion of electrolyte balance and prevention of complications resulting from abnormal or undesired serum electrolyte levels\nConcepts: PQL0113 (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tPerformedSpecimenMove.fromPositionDimensionThree (From Position Dimension Three)\tElectrolyte Management (Fluid/electrolyte balance regulation)\tRight to Die (Patient Rights)\tEvery Six Days (Temporal Concept)", + "output": "Electrolyte Management (Fluid/electrolyte balance regulation)" + }, + { + "input": "Definition: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides described as catalysis of the reaction: dUTP + 2 H2O = dUMP + 2 hydrogenphosphate + 2 H+.\nConcepts: dUTP phosphohydrolase activity (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)\tGNAI3 gene (Heterotrimeric G Protein Subunit Gene)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DYSF (Medical Device)\tVasoactive (Active)\tFAC100-Limit: Putting on Socks (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "dUTP phosphohydrolase activity (hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)" + }, + { + "input": "Definition: Document type described as a document, established by consensus and approved by a recognized body, that provides, for common and repeated use, rules, guidelines or characteristics for activities or their results.\nConcepts: Biospecimens Not Retained (Biospecimen Retained and/or Contains DNA Indicator)\tortataxel (Taxanes)\ttechnical standard (Intellectual Product)\tUNIT, ULTRAVIOLET SANITATION/STERILIZATION (FOR TOOTHBRUSHES), NON-STERILE (Medical Device)\tFINGER AGNOSIA (lateralizing cortical functions)", + "output": "technical standard (Intellectual Product)" + }, + { + "input": "Definition: Metastatic Carcinoma described as a small cell carcinoma that has metastasized from its original site of growth to another anatomic site.\nConcepts: (R)-4-hydroxymandelate metabolic process (monocarboxylic acid metabolic process)\tBreathalyzer (Diagnostic, Therapeutic, and Research Equipment)\tsmall cell carcinoma metastatic (Carcinoma, Small Cell)\tApolizumab (Amino Acid, Peptide, or Protein)\tVein stripper (Medical Device)", + "output": "small cell carcinoma metastatic (Carcinoma, Small Cell)" + }, + { + "input": "Definition: something described as a position, site, or point on the body where electrocardiogram leads are attached.\nConcepts: Electrocardiograph Lead Placement Location (Location)\tantileukemic agent (Antineoplastic Agents)\tDENT INFECT CONTROL (Infectious disease prevention / control)\tLymphatic Sarcomas (Primary malignant neoplasm)\tCentral Asian ovcharka (Mammal)", + "output": "Electrocardiograph Lead Placement Location (Location)" + }, + { + "input": "Definition: Enterobacteriaceae described as gram-negative rods isolated from human urine and feces.\nConcepts: Players, Audio (Electromechanical Devices)\tSilent miscarriage (Fetal Diseases)\tProvidencia species (Morganellaceae)\tR21/R33 Mechanism (Governmental or Regulatory Activity)\tAutologous IL-2-expressing B-CLL Vaccine (Autologous Tumor Cell Vaccine)", + "output": "Providencia species (Morganellaceae)" + }, + { + "input": "Definition: something described as the reason for performing a trial in terms of the scientific questions to be answered by the analysis of data collected during the trial. NOTE: The primary objective is the main question to be answered and drives any statistical planning for the trial (e.g., calculation of the sample size to provide the appropriate power for statistical testing). Secondary objectives are goals of a trial that will provide further information on the use of the treatment.\nConcepts: Clinical Trial Objective (Intellectual Product)\tcase cart (Carts, Central Supply)\tcontingency management (Behavior Modification & Therapy)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Washing Your Whole Body (Intellectual Product)\tPWWP2A Gene (Ligand Binding Protein Gene)", + "output": "Clinical Trial Objective (Intellectual Product)" + }, + { + "input": "Definition: Research Activity described as a type of study designed to evaluate one or more interventions where the primary intent is to maximize comfort, minimize side effects or mitigate against a decline in the subject's health or function. In general, supportive care interventions are not intended to cure a disease.\nConcepts: cPLA2delta (Gene or Genome)\tMixed Germ Cell Neoplasm of the Testis (Neoplastic Process)\tSUPPORTIVE CARE (Research Activity)\tAbnormal autonomic nervous system morphology (Anatomical Abnormality)\tFrostbite, NOS (Cold Injury)", + "output": "SUPPORTIVE CARE (Research Activity)" + }, + { + "input": "Definition: Pharmacologic Substance described as a cancer vaccine comprised of autologous dendritic cells pulsed with synthetic glioma-associated antigen (GAA) peptides with potential antineoplastic activity. Upon administration, this vaccine may stimulate anti-tumoral cytotoxic T lymphocyte (CTL) and antibody responses against GAA peptide-expressing glioma cells, resulting in tumor cell lysis.\nConcepts: RT - Radiotherapy (Malignant Neoplasms)\tGAA peptide-pulsed autologous dendritic cell vaccine (Dendritic Cell Vaccine)\tstamen formation (Biologic Function)\tsigma factor antagonist complex (Cell Component)\t2,4,4-trimethylpentanoyl-CoA dehydrogenase activity (Molecular Function)", + "output": "GAA peptide-pulsed autologous dendritic cell vaccine (Dendritic Cell Vaccine)" + }, + { + "input": "Definition: Component of Study Protocol described as planned length of observation for a single subject.\nConcepts: Length of Trial (Component of Study Protocol)\tmetabolism by organism of cell wall cellulose in other organism involved in symbiotic interaction (multi-organism glucan metabolic process)\tEndopeptidase Asp-N Protein Cleavage Reagent (Protein Cleavage Reagent)\tantibody-drug conjugate SC-003 (Immunologic Factor)\tRENAL DYSPLASIA-LIMB DEFECTS SYNDROME (Disease or Syndrome)", + "output": "Length of Trial (Component of Study Protocol)" + }, + { + "input": "Definition: Dwarfism described as height less than two standard deviations below the mean for the age and sex of the reference population for the age and sex of the individual for which no underlying cause can be identified.\nConcepts: ISS (Short stature)\tMicro-Health Insurances (Health Care Activity)\tEstimated intake of energy via gastroenteral route in 24 hours (Quantitative Concept)\taminoglycoside antibiotic metabolic process (glycoside metabolic process)\tkaempferol-3-rhamnoside-glucosyltransferase activity (Molecular Function)", + "output": "ISS (Short stature)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Pronate/supinate-hands, right.\nConcepts: UHDR1-Pronate/Supinate: Hands: Right (UHDRS 1999 Version Clinical Classification Question)\tWere IV Narcotic/Opiate Agents Administered (CPTAC Questions)\tFOLFOXIRI Plus Avastin (Regimen Used to Treat Colorectal Carcinoma)\tMeningeal Cell Count (Laboratory Procedure)\tEmotional intelligence (Intelligence)", + "output": "UHDR1-Pronate/Supinate: Hands: Right (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: something described as identifiable or distinctive quality of food or drink perceived with the combined senses of taste and smell; substance used to give food or drink an identifiable or distinctive taste.\nConcepts: Polycomb Repressive Complex Protein (Chromosomal Proteins, Non-Histone)\tBitemporal hollowing (Abnormality of the periorbital region)\tRadiology Chiropractor (Professional or Occupational Group)\tflavor (Property or Attribute)\tMesotheliomas, Malignant (Adult Solid Neoplasm)", + "output": "flavor (Property or Attribute)" + }, + { + "input": "Definition: Fibrillins described as a fibrillin (FBN2) that functions to regulate the assembly of ELASTIC FIBERS. Mutations in the FBN2 gene are associated with congenital contractural ARACHNODACTYLY.\nConcepts: Vallecula epiglottica (Oropharyngeal)\tFibrillin 2 (Biologically Active Substance)\tJealousy (OTHER EMOTIONS RELATED TO AFFECT OR MOOD)\tMinocycline (Anti-Bacterial Agents)\tCELLSIM (Laboratory Procedure)", + "output": "Fibrillin 2 (Biologically Active Substance)" + }, + { + "input": "Definition: tRNA modification described as the addition a sulfur atom to a nucleotide in a tRNA molecule.\nConcepts: Enteral Route of Administration (Gastroenteral route)\tEstimated intake of empty energy food servings in 24 hours (Quantitative Concept)\ttRNA thio-modification (tRNA modification)\tPerson (Group)\tresponse to prostaglandin stimulus (response to fatty acid)", + "output": "tRNA thio-modification (tRNA modification)" + }, + { + "input": "Definition: LIM Domain Proteins described as serine protein kinases involved in the regulation of ACTIN polymerization and MICROTUBULE disassembly. Their activity is regulated by phosphorylation of a threonine residue within the activation loop by intracellular signaling kinases such as P21-ACTIVATED KINASES and by RHO KINASE.\nConcepts: DNA Intercalation (Genetic Function)\tNON-ST ELEVATION MYOCARDIAL INFARCTION (Finding)\tAllopathic & Osteopathic Physicians; Pathology, Anatomic Pathology (Physicians; Physician/Osteopath)\tKinases, Lim (Protein-Serine-Threonine Kinases)\tRAD54B wt Allele (Gene or Genome)", + "output": "Kinases, Lim (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: something described as one or more characters and/or numbers that are used to identify, name, or characterize the nature, properties, or contents of genomic sequences, mRNA transcripts, protein products, or other class of entities that occurs throughout the genome.\nConcepts: Broad long bone diaphyses (Abnormal diaphysis morphology)\tcell wall skeleton (Cell Wall)\tAutosomal recessive cerebellar ataxia, epilepsy, intellectual disability syndrome due to TUD deficiency (Cerebellar Ataxia)\tGenomic Identifier (Conceptual Entity)\tHyperplasia of the intermaxillary bone (Abnormality of the premaxilla)", + "output": "Genomic Identifier (Conceptual Entity)" + }, + { + "input": "Definition: Dietary Supplements described as an amino acid and herbal supplement with libido-enhancing activity. L-arginine/korean ginseng/Ginkgo biloba/damiana-based supplement contains a blend of the amino acid L-arginine and the herbs Korean ginseng, Ginkgo biloba, and damiana (Turnera aphrodisiaca) in addition to 14 other vitamins and minerals. The semi-essential amino acid L-arginine is a precursor for nitric oxide (NO); Korean ginseng may enhance the conversion of L-arginine into NO by NO synthase; and Ginkgo biloba may promote microvascular circulation. This agent may increase NO production, resulting in vasodilatation and an enhanced circulation critical to sexual function and arousal. The damiana component may exert an anxiolytic effect and stimulate sexual behavior. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67093\" active clinical trials using this agent.\nConcepts: Gi-Go G-Proteins (GTP-Binding Protein alpha Subunits)\tL-Arginine-Based Nutritional Supplement (Pharmacologic Substance)\tCAMLG Gene (Gene or Genome)\tIPAQ Long Last 7 Days Self-Administered Format Version - Moderate Garden Minutes per Day (Intellectual Product)\tExpiration Relaxation Time (Pulmonary function tests)", + "output": "L-Arginine-Based Nutritional Supplement (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding of head and neck region described as pathological processes of the VESTIBULOCOCHLEAR NERVE, including the branches of COCHLEAR NERVE and VESTIBULAR NERVE. Common examples are VESTIBULAR NEURITIS, cochlear neuritis, and ACOUSTIC NEUROMA. Clinical signs are varying degree of HEARING LOSS; VERTIGO; and TINNITUS.\nConcepts: Eculizumab-containing product (Selective immunosuppressants)\tChloride, Hydrogen (Acid preparations, digestives)\tdisease (or disorder); nerve, acoustic (Peripheral Nervous System Diseases)\tANCESTIM (Recombinant Proteins)\tFibrohistiocytic tumor (Skin lesion)", + "output": "disease (or disorder); nerve, acoustic (Peripheral Nervous System Diseases)" + }, + { + "input": "Definition: Medical Device described as PQCMC data submitted for an HDE application.\nConcepts: Exostoses (Multiple) 2 wt Allele (EXT2 gene)\tAdditional Sex Combs Like 1 Gene Mutation (Cell or Molecular Dysfunction)\tTREPONEMAL INFECT (Gram-Negative Bacterial Infections)\tSquamous cell carcinoma, keratoacanthoma-type (Neoplastic disease of uncertain behavior)\tExemptions, Humanitarian Device (Premarket Approval Application)", + "output": "Exemptions, Humanitarian Device (Premarket Approval Application)" + }, + { + "input": "Definition: Congenital Abnormality described as condition where foot exhibits an arch when non-weight bearing but shows collapse of the arch in stance.\nConcepts: ketosis (Ketoacidosis)\tIdiopathic thrombocytopenic purpura (Thrombocytopenia)\tTAN1 protein, human (Amino Acid, Peptide, or Protein)\tCongenital pes valgo planus (Congenital Foot Deformity)\tMinimum Heart Rate by Electrocardiogram (ECG Measurement)", + "output": "Congenital pes valgo planus (Congenital Foot Deformity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as areas of cerebral cortex defined on the basis of their connectivity. Most projections to and from association areas are cortico-cortical. Association cortex is found in parts of the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe ( Carpenter-1983 ).\nConcepts: Abnormality of the pubis (Anatomical Abnormality)\tSecalins (Amino Acid, Peptide, or Protein)\tConventional release dental stick (Dental dosage form)\tassociation cortex (Cerebral cortex)\tbrachydactyly-dwarfism-hearing loss-microcephaly-mental retardation syndrome (Disease or Syndrome)", + "output": "association cortex (Cerebral cortex)" + }, + { + "input": "Definition: ligase activity, forming carbon-carbon bonds described as catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.\nConcepts: 3p24.3 (Chromosome band)\tCoA carboxylase activity (Molecular Function)\tRooming (Administrative Activity)\tHIGH PRESSURE LIQUID CHROMATOGRAPHY, TRICYCLIC ANTIDEPRESSANT DRUGS (Medical Device)\tMODOTUXIMAB (Anti-EGFR Monoclonal Antibody)", + "output": "CoA carboxylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue.\nConcepts: 20-alpha-hydroxysteroid dehydrogenase (Enzyme)\tPast Seven Days Frequency of Nosebleeds (Clinical or Research Assessment Question)\tecdysis, collagen and cuticulin-based cuticle (molting cycle process)\tReviews, Concurrent (Occupational Activity)\ttRNA pseudouridylation guide activity (tRNA modification guide activity)", + "output": "tRNA pseudouridylation guide activity (tRNA modification guide activity)" + }, + { + "input": "Definition: Thyroid Cancer Pathologic Regional Lymph Nodes TNM Finding v6 described as thyroid cancer with metastasis to pretracheal, paratracheal or prelaryngeal/Delphian lymph nodes (Level VI lymph nodes).\nConcepts: Thick split thickness graft of skin (Biomedical or Dental Material)\tSGA for Weight and Length (Finding)\tCAMSG (Minor Salivary Gland Adenocarcinoma)\tplasma membrane bounded cell projection cytoplasm (Cell Component)\tThyroid Cancer pN1a TNM Finding v7 (Thyroid Cancer Pathologic Regional Lymph Nodes TNM Finding v7)", + "output": "Thyroid Cancer pN1a TNM Finding v7 (Thyroid Cancer Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: Disease or Syndrome described as inflammation of the liver characterized by a mononuclear cell infiltrate whereby portal inflammatory cells extend through the limiting plate between the portal tract and liver parenchyma. []\nConcepts: ANTEROMEDIAL (Spatial Concept)\tInterface hepatitis (Liver)\tCup Feeding Establishment: Infant (Digestion & Nutrition)\tAcute bilateral depigmentation of iris (Disorder of anterior chamber of eye)\taldosterone secretion (mineralocorticoid secretion)", + "output": "Interface hepatitis (Liver)" + }, + { + "input": "Definition: C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Have you actually had any thoughts of killing yourself? (Since Study Start).\nConcepts: BAF53A (Gene or Genome)\tC-SSRS Already Enrolled Subjects - Non-Specific Active Suicidal Thoughts (C-SSRS Already Enrolled Subjects Questionnaire Question)\tK-Ras 2 G12Y (Cell or Molecular Dysfunction)\tNursing, Private Practice (Health Care Activity)\tRecurrent Childhood Hepatoma (Childhood Hepatocellular Carcinoma)", + "output": "C-SSRS Already Enrolled Subjects - Non-Specific Active Suicidal Thoughts (C-SSRS Already Enrolled Subjects Questionnaire Question)" + }, + { + "input": "Definition: something described as human TLR6 wild-type allele is located within 4p14 and is approximately 3 kb in length. This allele, which encodes toll-like receptor 6 protein, is involved in both pathogen recognition and innate immunity activation.\nConcepts: zinc binding (transition metal ion binding)\tReynolds Cardiovascular Disease 10-Year Risk Score Clinical Classification Test Name (Intellectual Product)\tDental Materials, Cavity Varnish (Dental Materials)\tAppendiceal Carcinoma cM0 TNM Finding v7 (Finding)\tCD286 (Gene or Genome)", + "output": "CD286 (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as baseline Dyspnea Index test code.\nConcepts: Abnormal rectus muscle physiology (Pathologic Function)\tDrug, Anticonvulsive (neurological agents)\tsulforaphane (Isothiocyanate)\tRecruitment Target (Target)\tCDISC Clinical Classification BDI Test Code Terminology (CDISC Clinical Classification Terminology)", + "output": "CDISC Clinical Classification BDI Test Code Terminology (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: vaginal preparations described as an element with atomic symbol I, atomic number 53, and atomic weight of 126.90.\nConcepts: cellular response to dihydridosulfur (Cell Function)\tInflammatory pseudotum lung (Inflammation of specific body organs)\tFAROE ISLANDS (Geographic Area)\tProduct containing iodine (I [Preparations])\tInterleukin 21 (Cytokine Measurement)", + "output": "Product containing iodine (I [Preparations])" + }, + { + "input": "Definition: Behavior Therapy described as behavioral science applied with the aim of improving socially important issues such as behavior problems and learning. For individuals diagnosed with intellectual and developmental disabilities including AUTISM, techniques can be categorized as comprehensive or focused.\nConcepts: Meningioma of Posterior Foramen Magnum (Neoplastic Process)\tIVD Test Reagent/Kits, Immunoassay, Fertility Hormone, Dehydroepiandrosterone/Dehydroepiandrosterone-Sulfate (IVD Test Reagent/Kits, Immunoassay, Fertility Hormone)\tETEC LtA/ST1a/ST1b DNA (Deoxyribonucleic Acid Measurement)\tpentobarbitone (Barbiturates, hypnotics and sedatives, plain)\tApplied Behavior Analysis (Behavior Therapy)", + "output": "Applied Behavior Analysis (Behavior Therapy)" + }, + { + "input": "Definition: Personality disorders with dramatic behaviour described as personality disorder characterized by conflict with others, low frustration tolerance, inadequate conscience development, and rejection of authority and discipline.\nConcepts: sociopathic; personality disorder (Personality)\tUltrasonics (Pitch Frequency)\tCOLONY-STIMULATING FACTORS (Colony-Stimulating Factors)\tKIAA1596 (FA Complementation Group Gene)\tTesters, Power Line Receptacle, Mechanical (Device associated with batteries)", + "output": "sociopathic; personality disorder (Personality)" + }, + { + "input": "Definition: Pharmacologic Substance described as a probiotic containing a specific strain of the anaerobic, butyric acid-forming Gram-positive bacterium Clostridium butyricum (C. butyricum), with potential immunomodulatory, anti-inflammatory and antineoplastic activities. Clostridium butyricum MIYAIRI (CBM) 588 is the 588th MIYAIRI strain, isolated from a soil sample in Japan in 1963. Upon oral administration of C. butyricum CBM 588 probiotic strain, C. butyricum modulates the composition of the normal gastrointestinal (GI) microflora, by increasing the beneficial bacteria and decreasing the harmful bacteria, and helps maintain adequate colonization of the GI tract, thereby improving digestion and preventing GI disturbances. These bacteria and the butyric acid produced by them create an environment unfavorable to pathogens by adhering to human epithelial cells and forming a protective mucosal barrier. This prevents attachment of pathogens and reduces the risk of infection. By restoring gut microbiota, these bacteria may restore or enhance intestinal immune responses. C. butyricum induces interleukin-10-producing macrophages in inflamed mucosa via the Toll-like receptor 2 (TLR2)/myeloid differentiation primary response gene 88 (MyD88) pathway, thereby decreasing inflammatory responses. In addition, CBM588 may exert antineoplastic activity by inducing the release of the endogenous cytokine tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) from intracellular stores in polymorphonuclear neutrophils (PMNs), most likely involving matrix metalloproteinase 8 (MMP-8) and the Toll-like receptors (TLR)2/4 signaling pathways. This results in TRAIL-mediated induction of apoptosis in susceptible tumor cells.\nConcepts: VERY LONG CHAIN FATTY ACIDS (Measurement of substance)\tdamol/L (moles per unit volume)\tC. butyricum strain MIYAIRI 588 (Pharmacologic Substance)\tliquid chromatography with tandem mass spectrometry (Laboratory Procedure)\tComputer-Aided Design/Manufacturing Systems, Orthopedic, Spinal Orthosis/Prosthesis/Seat Cushion (Computer-Aided Design/Manufacturing Systems, Orthopedic)", + "output": "C. butyricum strain MIYAIRI 588 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as any of the aggregations of cell bodies of primarily adrenergic neurons of the sympathetic nervous system.\nConcepts: Second Times Nanomole per Milliliter (Measurement Unit Description)\tSYMPATHETIC GANGLIA (Sympathetic Nervous System)\tVirological (biological)\tContracture of the distal interphalangeal joint of the 4th finger (Anatomical Abnormality)\tPAMP (Biologically Active Substance)", + "output": "SYMPATHETIC GANGLIA (Sympathetic Nervous System)" + }, + { + "input": "Definition: X-Ray Computed Tomography described as an imaging technique of the heart and neighboring structures involving helical computed tomography and computer software to generate high-resolution 2-dimensional and 3-dimensional images.\nConcepts: regulation of interleukin-14 production (regulation of cytokine production)\tIVD Test Reagent/Kits, Clinical Chemistry, Protein, Glycated, Fructosamine (IVD Test Reagent/Kits, Clinical Chemistry, Protein, Glycated)\tTAS-103 (Topoisomerase Inhibitors)\tOABQ0106 (OAB-q Questionnaire Question)\tcardiac computerized tomographic angiography (Diagnostic Procedure)", + "output": "cardiac computerized tomographic angiography (Diagnostic Procedure)" + }, + { + "input": "Definition: Telencephalon described as region in the ventral TELENCEPHALON located anterior to the OPTIC CHIASM, posterior to the OLFACTORY PEDUNCLE, rostral to the PIRIFORM AREA and ventral to the NUCLEUS ACCUMBENS.\nConcepts: MRC MMT Score, Extension (Score)\tCostochondritis, NOS (Cartilage Diseases)\tprotein-exporting ATPase activity (Molecular Function)\tOlfactory area (paleocortex)\tStudy Sponsor Type (Qualitative Concept)", + "output": "Olfactory area (paleocortex)" + }, + { + "input": "Definition: something described as a type of DNA repair that uses homologous recombination to resolve chromosomal double strand breaks. This process involves the invasion of a homologous region of an intact chromosome by the centromere-proximal end of the broken chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome.\nConcepts: Anti-nuclear antibody measurement, NOS (Laboratory Procedure)\tChildhood Central Nervous System Mature Teratoma (Benign Childhood Central Nervous System Neoplasm)\tThirteen (Quantitative Concept)\tgamma-tubulin complex assembly (protein-containing complex assembly)\tBreak-Induced Replication (recombinational repair)", + "output": "Break-Induced Replication (recombinational repair)" + }, + { + "input": "Definition: Intellectual Disability described as mental retardation syndrome affecting mostly males. The phenotype varies, consisting mostly of gynecomastia, obesity, speech disability, hypogonadism, and small feet.\nConcepts: PQL1615 (PedsQL Neuromuscular Module Acute Version 3.0 Young Child Report Questionnaire Question)\tNational Institute of Diabetes and Digestive and Kidney Diseases (United States National Institutes of Health)\tVasquez syndrome (Disease or Syndrome)\tBestrophin Family (Biologically Active Substance)\tGag:267-274 peptide vaccine (Pharmacologic Substance)", + "output": "Vasquez syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Medical Device described as temporary humeral shoulder joint components designed for use during shoulder joint reconstruction procedures to determine/confirm proper sizing and positioning of the permanent/definitive shoulder prosthesis. These devices are designed to be temporarily inserted and/or attached, and then are removed from the surgical site so that the permanent implants can be placed. Trial humeral head and stem components are typically available.\nConcepts: Advanced Small Intestinal Neuroendocrine Carcinoma (Advanced Neuroendocrine Carcinoma)\tCabinets, Filing, Digital Versatile Disk (Manufactured Object)\tCSS0422B (C-SSRS Baseline/Screening Version Questionnaire Question)\tTrial Prostheses, Joint, Shoulder, Humeral Component (Trial Prostheses, Joint, Shoulder)\tSacral Extension (Functional finding)", + "output": "Trial Prostheses, Joint, Shoulder, Humeral Component (Trial Prostheses, Joint, Shoulder)" + }, + { + "input": "Definition: Anti-Infective Agents described as a drug used to treat respiratory syncytial virus (RSV) infection in the lungs.\nConcepts: 1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl- (Ribonucleosides)\tTranslocation-Associated Notch Protein TAN-1 Ser2467AlafsTer15 (NOTCH1 NP 060087.3:p.S2467 Frameshift)\tinterleukin-4 receptor complex (Cell Component)\tPLK3 wt Allele (Gene or Genome)\tArea 32 of Brodmann of guenon (Body Location or Region)", + "output": "1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl- (Ribonucleosides)" + }, + { + "input": "Definition: Intellectual Product described as a character string that can identify any kind of resource on the Internet, including images, text, video, audio and programs. The most common example of a URI is a URL.\nConcepts: CCL 020 CHEMOKINE (Amino Acid, Peptide, or Protein)\tEdge or Boundary Artifact (Finding)\tarticular disease (Bones, Joints and Muscles)\tURI (Identifier)\tElectrogoniometers, Double-Axis (Electrogoniometers)", + "output": "URI (Identifier)" + }, + { + "input": "Definition: enzyme activity described as catalytic activity that acts to modify RNA.\nConcepts: Water Recovery Systems, Steam Sterilizing Unit (Manufactured Object)\tcatalytic activity, acting on RNA (Molecular Function)\tFinding of bladder control (Elimination outcomes)\tmicrowave thermotherapy (Therapeutic procedures NEC)\tSinks (Manufactured Object)", + "output": "catalytic activity, acting on RNA (Molecular Function)" + }, + { + "input": "Definition: Structure of commissure of larynx described as the posterior surface of the glottic opening at the level of the vocal cords.\nConcepts: Posterior Commissures, Laryngeal (Structure of commissure of larynx)\tSOURCE, TELETHERAPY, RADIONUCLIDE (Medical Device)\tExpanded DRS-PI Caregiver Version - Manage Clothing When Toileting (Expanded DRS-PI Caregiver Version Questionnaire Question)\tBackflow (Improper Flow or Infusion)\tBioassay Class (Conceptual Entity)", + "output": "Posterior Commissures, Laryngeal (Structure of commissure of larynx)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside].\nConcepts: 1-hexadecyl-2-acetylglycerol acyltransferase activity (Molecular Function)\tSmokers, Tobacco (Population Group)\tNasoduodenal use (Intraduodenal Route of Drug Administration)\tanthocyanidin 3-O-glucoside 6''-O-acyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tReagents, Molecular Assay, Inborn Disorder, Chromosomal, Sexual, Klinefelter (Indicator, Reagent, or Diagnostic Aid)", + "output": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: something described as the hardening or polymerization of bonding agents (DENTAL CEMENTS) via chemical reactions, usually involving two components. This type of dental bonding uses a self-cure or dual-cure system.\nConcepts: PKC 412 (Organic Chemical)\tEQ5D02TN (CDISC Questionnaire Terminology)\tBis-Trimethyl-Ammonium Compounds (Quaternary Ammonium Compounds)\tDental Bonding, Self-Cured (Therapeutic or Preventive Procedure)\tMISONIDAZOLE (Antiprotozoal Agents)", + "output": "Dental Bonding, Self-Cured (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as an indication as to whether the female subject has ever had an induced abortion procedure.\nConcepts: Induced Abortion Indicator (Indicator)\tHYPEREMESIS GRAVIDARUM (Vomiting)\tO-glycan processing (Molecular Function)\tShamanic self-healing education each 15 minutes (Shamanism)\tPerformedActivity.orderDate (Order Date)", + "output": "Induced Abortion Indicator (Indicator)" + }, + { + "input": "Definition: Anabolism described as the chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.\nConcepts: Obstetric Pain (Pain)\tTrachyspermum ammi (L.) Sprague (Oils, Volatile)\tthymine metabolism (pyrimidine nucleobase metabolic process)\tOngoing loss of nerve cells (Cell or Molecular Dysfunction)\tnicotine anabolism (Molecular Function)", + "output": "nicotine anabolism (Molecular Function)" + }, + { + "input": "Definition: something described as using speech and language rehabilitation therapy, including initiating, coordinating and/or sequencing muscle movement exercises, with a patient to improve his or her proper vocalization.\nConcepts: Never Marketed (Other Marketing Category)\tpan-hematopoietic expression protein, human (Amino Acid, Peptide, or Protein)\tvrbl apraxia spch&lang rehab (Therapeutic or Preventive Procedure)\tVery Satisfied (Clinical or Research Assessment Answer)\tCCQ 1 Week Version - Short of Breath at Rest (Intellectual Product)", + "output": "vrbl apraxia spch&lang rehab (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Non-Neoplastic Corneal Disorder described as an abnormality of the cornea that is characterized by opacity of one or parts of the cornea.\nConcepts: trehalose permease activity (disaccharide transmembrane transporter activity)\tCORNEAL DYSTROPHY (Corneal and scleral disorders congenital)\tmefloquine HCl (Organic Chemical)\tPHQ03-Anxiety Attack Afraid You Dying (PHQ Screener Version Questionnaire Question)\tSurveillance: Late Pregnancy (Childbearing Care)", + "output": "CORNEAL DYSTROPHY (Corneal and scleral disorders congenital)" + }, + { + "input": "Definition: Intradermal Route of Drug Administration described as intradermal injection is a method of drug administration within the substance of the skin, particularly the dermis.\nConcepts: SNX29 (Regulatory Protein)\tIntradermal Injection (Intradermal Route of Drug Administration)\tdetection of stimulus involved in mitotic spindle assembly checkpoint (detection of stimulus involved in mitotic spindle checkpoint)\tAbnormality of neutrophils (White blood cell finding)\tgiant cell glioblastoma, adult (Giant Cell Glioblastoma)", + "output": "Intradermal Injection (Intradermal Route of Drug Administration)" + }, + { + "input": "Definition: Procedures relating to control, restraint, seclusion and segregation described as solitary containment in a fully protective environment with close surveillance by nursing staff for purposes of safety or behavior management\nConcepts: Syndrome of juxtaglomerular hyperplasia with secondary aldosteronism (Other hyperaldosteronism)\tMentor's Statement (Document type)\tSeclusion (Precautionary nursing procedure, NOS)\tLymph node group (Anatomical set)\tspecification of plant organ identity (regionalization)", + "output": "Seclusion (Precautionary nursing procedure, NOS)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(11;17)(q23;q12-21) which fuses the 5' half of the MLL gene to the 3' half of the LASP1 gene. This rearrangement is associated with infant acute myeloid leukemia.\nConcepts: CHOLINERGIC AG NICOTINIC (Cholinergic receptor stimulating agent)\tInfranatant (Body Substance)\tLASP1-MLL Fusion Gene (Gene or Genome)\tPneumoperitoneum needle (Medical Device)\tpositive regulation of cytokinin mediated signalling (positive regulation of signal transduction)", + "output": "LASP1-MLL Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as the formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG.\nConcepts: peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine (Molecular Function)\ttenia tecta, ventral part (Body Part, Organ, or Organ Component)\tGrade 3 Proctitis, CTCAE (Proctitis, CTCAE)\tKilosecond (Quantitative Concept)\tPads, Incontinence (Medical Device)", + "output": "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine (Molecular Function)" + }, + { + "input": "Definition: mitochondrial tRNA modification described as the attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in mitochondrial tRNAs that decode ANN codons (where N is any base).\nConcepts: Extremely Severe Hallucination (Hallucination Severity)\thydrogen-transporting ATP synthase, stator stalk (Cell Component)\tTripterygium (Plant)\tInspiratory time (Finding)\tmitochondrial tRNA t6A modification (tRNA threonylcarbamoyladenosine modification)", + "output": "mitochondrial tRNA t6A modification (tRNA threonylcarbamoyladenosine modification)" + }, + { + "input": "Definition: Arteriospasm described as spasm of the large- or medium-sized coronary arteries.\nConcepts: metanephric glomerular parietal epithelial cell development (metanephric glomerular epithelial cell development)\tCoronary Artery Vasospasm (Myocardial Ischemia)\tRegulatory Application Document Subtype (Document Subtype)\tmyxoid cyst (Cyst)\tarea 8 of Walker (Body Location or Region)", + "output": "Coronary Artery Vasospasm (Myocardial Ischemia)" + }, + { + "input": "Definition: Arterial thrombosis described as the formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).\nConcepts: IPA03-Walking Work Hours per Day (Intellectual Product)\tFixed Loop Instruments (Medical Device)\tCerebral Hodgkin's Disease (Neoplastic Process)\tAmyotrophy NOS (Degenerative disorder of muscle)\tCEREBRAL INFARCTION (Disease or Syndrome)", + "output": "CEREBRAL INFARCTION (Disease or Syndrome)" + }, + { + "input": "Definition: something described as someone who lives at a particular place for a prolonged period or who was born there.\nConcepts: Resident (Persons)\tlateral vestibulospinal tract of the medulla (White matter of medulla oblongata)\tnfxn prkxns (Therapeutic or Preventive Procedure)\tIVD Test Reagent/Kits, Molecular Assay, RNA Expression, Multiple Sclerosis (IVD Test Reagent/Kits, Molecular Assay, RNA Expression)\tspindle pole body (Cell Component)", + "output": "Resident (Persons)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Baseline/Screening Version - Have you started to work out or worked out the details of how to kill yourself? Do you intend to carry out this plan? (Lifetime).\nConcepts: DentalRoute (Drug Administration Routes)\tCSS0405A (C-SSRS Baseline/Screening Version Questionnaire Question)\tRomani (Language)\tpurine deoxyribonucleoside diphosphate degradation (purine nucleoside diphosphate catabolic process)\tADCS-ADL Severe Dementia - Alone at Home for Less Than One Hour (Intellectual Product)", + "output": "CSS0405A (C-SSRS Baseline/Screening Version Questionnaire Question)" + }, + { + "input": "Definition: Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Lymph Nodes TNM Finding v8 described as involvement of central lymph nodes.\nConcepts: histone cluster 1 H2B family member d (Gene or Genome)\tChildren (Child)\tPrimary Cutaneous Lymphoma Other Than Mycosis Fungoides and S\u00e9zary Syndrome N3 TNM Finding v8 (Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Lymph Nodes TNM Finding v8)\tstage II lip and oral cavity cancer (stage, lip and oral cavity cancer)\tAnti-CEA IgCD28TCR-Transduced Autologous T Cells (Antineoplastic Immune Cell)", + "output": "Primary Cutaneous Lymphoma Other Than Mycosis Fungoides and S\u00e9zary Syndrome N3 TNM Finding v8 (Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: something described as a cause of obesity that results from inheritance of two copies of chromosome 14 from the mother and no copy of chromosome 14 from the father.\nConcepts: 355 DEPENDOVIRUS (Virus)\tMaternal Uniparental Disomy Chromosome 14 Syndrome (Disease or Syndrome)\tInteroperability Problem Identified (Device Evaluation Result)\tIntrahepatic Bile Duct Cancer Pathologic TNM Finding v7 (Intrahepatic Bile Duct Cancer TNM Finding v7)\tF12a Measurement (Laboratory Procedure)", + "output": "Maternal Uniparental Disomy Chromosome 14 Syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Ophthalmic Tonographs described as electronic recorders designed for continuous storage of data that show changes in intraocular pressure (IOP). These recorders typically consist of a wearable electronic recorder that receives signals from an electro-mechanical sensor that is embedded in a disposable contact lens or implanted in the eye. These signals provide information on IOP changes. The sensor incorporates a wireless transmitter that delivers the signals, usually during a 24-hour time period (or less) that includes sleep time. These recorders typically consist of a wearable electronic recorder that receives signals providing information on IOP changes from an electro-mechanical sensor that is embedded in a disposable contact lens or implanted in the eye; the sensor incorporates a wireless transmitter that delivers the signals usually during a time period of 24 hours or less including sleep time. The data stored in the recorder is then downloaded to a computer (e.g., personal computer) using a dedicated software that permits the analysis of the recorded data by an ophthalmologist. IOP recorders are mainly used to facilitate the diagnosis and evaluation of glaucoma.\nConcepts: Disintegration per Second (Quantitative Concept)\tRecorders, Electronic Storage, Data, Intraocular Pressure (Ophthalmic Tonographs)\tCutaneous Melanoma cN1 TNM Finding v7 (Finding)\tEORTC QLQ-C30 Version 3 - Limited Hobbies or Leisure Activities (EORTC QLQ-C30 Version 3 Questionnaire Question)\tTumor Suppressor p53 R175H (Cell or Molecular Dysfunction)", + "output": "Recorders, Electronic Storage, Data, Intraocular Pressure (Ophthalmic Tonographs)" + }, + { + "input": "Definition: something described as paced Tapping Test (Paced Tapping) The maximum intertap interval within the self-paced tapping phase of Trial n (in milliseconds).\nConcepts: Gametogenesis, Plant (Plant Physiological Processes)\tneck portion of tanycyte (Cell Component)\tpositive regulation of astrocyte activation (Cell Function)\tPaced Tapping - Maximum Interval Self Trial (Intellectual Product)\tEnteric intraneuronal nuclear inclusion bodies (Abnormality of enteric neuron morphology)", + "output": "Paced Tapping - Maximum Interval Self Trial (Intellectual Product)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a rare porphyria characterised by a pre-existing myeloid disorder, skin fragility and blistering on the exposed areas, and haemorrhagic bullae typically on the back of the hands. Urine, plasma and faecal porphyrins are increased.\nConcepts: CALICIVIRUS (RNA Viruses)\tOther Management Occupations (Occupation or Discipline)\tErythropoietic uroporphyria associated with myeloid malignancy (Disorder of hematopoietic morphology)\tRadiation Fibrosis (Radiation Sickness)\tshort chain enoyl coenzyme A hydratase activity (hydro-lyase activity)", + "output": "Erythropoietic uroporphyria associated with myeloid malignancy (Disorder of hematopoietic morphology)" + }, + { + "input": "Definition: negative regulation of cellular biosynthetic process described as any process that stops, prevents or reduces the frequency, rate or extent of sinapate ester biosynthesis.\nConcepts: SYSTEM, PERITONEAL, AUTOMATIC DELIVERY (Medical Device)\tInternational Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format Questionnaire Test Name (CDISC Questionnaire Terminology)\tdentine mineralization (Organ or Tissue Function)\tExternal Ear Basal Cell Carcinoma (External Ear Carcinoma)\tinhibition of sinapate ester biosynthesis (Molecular Function)", + "output": "inhibition of sinapate ester biosynthesis (Molecular Function)" + }, + { + "input": "Definition: Chemoprotection described as the physiological processes and techniques used by the body to prevent neuronal injury and degeneration in the central nervous system following acute disorders or as a result of chronic neurodegenerative diseases.\nConcepts: amelanotic melanoma (Nevi and Melanomas)\tzinc finger protein 451 (Ligase Gene)\tEnoblituzumab (Amino Acid, Peptide, or Protein)\tSilver Birch Pollen IgG4 (Laboratory Procedure)\tProtection, Neural (Cell Function)", + "output": "Protection, Neural (Cell Function)" + }, + { + "input": "Definition: Finding described as both alleles match for one HLA locus\nConcepts: Prostate Ductal Adenocarcinoma, Cribriform Pattern (Carcinoma, Cribriform)\tMatch at Both HLA Alleles (HLA Match)\tAdenocarcinoma of Parathyroid Gland (Neoplasms)\tPharmaceutical Therapy, NOS (Therapeutic procedures NEC)\tAcademic Achievement Prediction (Intellectual Product)", + "output": "Match at Both HLA Alleles (HLA Match)" + }, + { + "input": "Definition: Potency Unit described as a unit of presentation used to represent the quantity of product that is found in a single dart device.\nConcepts: Loneliness Severity (Psychological Well Being)\tDOCK8 Mutation (Cell or Molecular Dysfunction)\tDart Dosing Unit (Potency Unit)\toxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\toccipital lobe (Body Part, Organ, or Organ Component)", + "output": "Dart Dosing Unit (Potency Unit)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Calibration, Toxicology (IVD Test Reagent/Kits, Immunoassay, Calibration)\tCTCAE Grade 1 Hair loss/alopecia (Finding)\t6-phosphogluconic carboxylase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tMucosal Immunity (secretory immune system)\tChoriogonadotropin Beta (Laboratory Procedure)", + "output": "6-phosphogluconic carboxylase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Quantitative Concept described as hours times picomoles per liter (area under the curve), divided by kilograms per meter squared (body mass index).\nConcepts: Allergy to house dust mites (Mite Infestations)\tSTAPHYLOCOCCUS AUREUS, PENICILLINASE NEGATIVE (Bacterium)\tGrade 2 Renal calculi (Renal Calculi, CTCAE)\t2,3-dihydroxydiphenyl ether dioxygenase activity (Molecular Function)\th*pmol/L/(kg/m2) (Quantitative Concept)", + "output": "h*pmol/L/(kg/m2) (Quantitative Concept)" + }, + { + "input": "Definition: Chromophilic cell described as a cell whose cytoplasm or granules stain readily with basic dyes.\nConcepts: ADAPTOR TO THE CORD, FOR TRANSURETHRAL SURGICAL INSTRUMENT (Medical Device)\tBasophilic Cell (Adenohypophysial Cell)\tday*mcg/mL (Measurement Unit Description)\tnegative regulation of cell migration involved in sprouting angiogenesis (negative regulation of sprouting angiogenesis)\tConventional release suspension for nebulizer (Inhalation Suspension)", + "output": "Basophilic Cell (Adenohypophysial Cell)" + }, + { + "input": "Definition: Abnormal eyelid morphology described as absence or underdevelopment of the eyelid.\nConcepts: inhibitory neuromuscular junction (Cell Component)\tDistal Ureter (Body Part, Organ, or Organ Component)\tEvery evening (Intervals of days)\tGTP Binding Protein alpha Subunits, Gq G11 (Enzyme)\tFailure of development of eyelid (Congenital Abnormality)", + "output": "Failure of development of eyelid (Congenital Abnormality)" + }, + { + "input": "Definition: something described as severity of signs and symptoms of decreased serum sodium\nConcepts: hydrolase activity, acting on ester bonds (Molecular Function)\tDIASTOLIC HEART MURMUR (Heart murmur, categorized by timing)\tgamma Butyrobetaine Dioxygenase (Mixed Function Oxygenases)\tHyponatremia Severity (fluid electrolyte)\trhombomere 5 development (rhombomere development)", + "output": "Hyponatremia Severity (fluid electrolyte)" + }, + { + "input": "Definition: something described as the most common form of Rubinstein-Taybi syndrome, caused by a mutation in the CREB binding protein (CREBBP) gene.\nConcepts: Number of Severe Episodes (Number of Episodes)\tBlood Pressure Finding (Cardiovascular test finding)\tRUBINSTEIN-TAYBI SYNDROME 1 (Rubinstein-Taybi Syndrome)\tCell Death Inhibition (negative regulation of cellular process)\tpyrimidine deoxyribonucleoside metabolic process (pyrimidine nucleoside metabolic process)", + "output": "RUBINSTEIN-TAYBI SYNDROME 1 (Rubinstein-Taybi Syndrome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a pegylated derivative of the cyclic tridecapeptide compstatin and inhibitor of complement component C3 (C3) activation, with potential use as a treatment for various diseases in which excessive complement activation plays a key role, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD). Upon administration, C3-targeted complement inhibitor APL-2 selectively binds to C3 and blocks the cleavage of C3 into C3a and C3b by C3 convertase. This prevents complement pathway activation, and inhibits complement-mediated inflammation and cell lysis. Pegylation increases compstatin's half-life, and increases its efficacy. Excessive complement activation plays a key role in various inflammatory and autoimmune diseases, and leads to tissue destruction. C3 is a crucial and central component of the complement system.\nConcepts: Ulcer aphthous oral (Disease or Syndrome)\tC3-targeted Complement Inhibitor APL-2 (Pharmacologic Substance)\tpositive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response (Biologic Function)\tamniotic stem cell differentiation (mesenchymal stem cell differentiation)\tPartial nephrectomy, laparoscopic with robot assistance (Laparoscopic partial nephrectomy)", + "output": "C3-targeted Complement Inhibitor APL-2 (Pharmacologic Substance)" + }, + { + "input": "Definition: Croatian translation of the Medical Subject Headings described as fields of inquiry in human constructs and concerns as opposed to natural processes and social relations. These are traditionally the study of literature, philosophy, and religion.\nConcepts: cositecan (Camptothecin Analogue)\tNPI - Say That He/She is Worried About Planned Events (Intellectual Product)\tHumanities (Portuguese translation of the Medical Subject Headings)\t1-Hydroxymidazolam (Laboratory Procedure)\tSS-B/La Protein (Biologically Active Substance)", + "output": "Humanities (Portuguese translation of the Medical Subject Headings)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine.\nConcepts: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen (monooxygenase activity)\tlaricitrin 4'-O-methyltransferase activity (methyltransferase activity)\tFMO3 wt Allele (FMO3 gene)\tReceptor, BMPR2 (Amino Acid, Peptide, or Protein)\tactomyosin structure (Cell Component)", + "output": "laricitrin 4'-O-methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 9p\nConcepts: CaCO3 (antacids containing calcium compounds)\t9p24.2 (Cell Component)\tAllatum, Corpus (Neurosecretory Systems)\tResidual Volumes (Functional Residual Capacity)\tplacenta; percreta (Morbidly adherent placenta)", + "output": "9p24.2 (Cell Component)" + }, + { + "input": "Definition: Disease or Syndrome described as an association of posterior choanal atresia with variable multiple abnormalities which include delayed mental and somatic development, ocular coloboma, ear abnormalities, deafness (usually associated with recurrent otitis, rather than ear anomalies), hypogenitalism, and heart defects. Many children have feeding, swallowing, and breathing difficulties and facial paralysis which are caused by multiple cranial nerve dysfunction. The syndrome occurs twice as often in girls as in boys and usually affects the right side of the body.\nConcepts: CD4-positive, alpha-beta T cell cytokine production (T cell cytokine production)\tCHARGE (coloboma-heart disease-atresia of choanae-retarded mental development and growth-genital hypoplasia-ear abnormalities-deafness) association or syndrome (Disease or Syndrome)\tFibrosis Assessment (Diagnostic Procedure)\tX-linked intellectual disability, nail dystrophy, seizures syndrome (Genetic Diseases, X-Linked)\tBGB324 (Organic Chemical)", + "output": "CHARGE (coloboma-heart disease-atresia of choanae-retarded mental development and growth-genital hypoplasia-ear abnormalities-deafness) association or syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Bag, device described as respiration simulators designed to mimic the pulmonary mechanics of the lungs by taking in air and then expelling it. Typically, they can simulate the normal adult, pediatric, and/or infant breathing characteristics (e.g., breath rate, inspiratory and expiratory times, tidal volume). Most simulators can also simulate abnormal (e.g., diseased) conditions. These simulators typically consist of a mechanism that includes one or more chambers, elastomer bellows, and simulated airways. They may also include measuring instruments (e.g., volume, time, pressure) and capabilities to adjust compliance and airway resistance and/or to simulate leaks. Lung simulators are used to test the performance of mechanical ventilators, spirometers, and anesthesia devices and/or for training purposes. Some lung simulators can display and/or record the performance of devices being tested (e.g., ventilators) using computing capabilities.\nConcepts: OAB-q Short Form - Affected Your Relationships with Family and Friends (OAB-q Short Form Questionnaire Question)\tpostsynaptic spectrin-associated cytoskeleton organization (postsynaptic cytoskeleton organization)\tSimulators, Respiration, Lung (Ventilator - respiratory equipment)\tPrimary Dyscalculias (Mental or Behavioral Dysfunction)\tRespiratory System Findings Result Standard Unit (Standard Result Unit)", + "output": "Simulators, Respiration, Lung (Ventilator - respiratory equipment)" + }, + { + "input": "Definition: Dietary Supplements described as a nutritional lipid emulsion consisting of both coconut oil-derived medium chain triglycerides (MCTs) and soybean oil-derived long chain triglycerides (LCTs). The LCTs in the MCT/LCT lipid emulsion supply the body with essential omega-6 fatty acids, which are needed as components of phospholipids in cell membranes and as precursors of eicosanoids. The MCTs mainly provide calories for energy. In addition to LCTs and MCTs, this lipid emulsion contains egg yolk lecithin, glycerol, and the antioxidant alpha-tocopherol (vitamin E).\nConcepts: histone methyltransferase activity (histone-lysine N-methyltransferase activity)\tGHBP (GHR gene)\tmesenchymal cell fate commitment (Cell Function)\tBeryllium Metaphosphate (Hazardous or Poisonous Substance)\tMCT/LCT Lipid Emulsion (Dietary Supplements)", + "output": "MCT/LCT Lipid Emulsion (Dietary Supplements)" + }, + { + "input": "Definition: something described as using group counseling techniques to assist clients in a group setting in managing and reducing their feelings of guilt. Service is billed in 60-minute increments per client.\nConcepts: Abnormality of prothrombin (Blood Coagulation Disorders)\tglt redxn asistnce grp ea.h (Therapeutic or Preventive Procedure)\tPlant Sources (Business Rules)\tMetarubricyte/Total Cells (Blood Cell Count Ratio Measurement)\tMelanin-Pigmented Dendritic Cells Present (Finding)", + "output": "glt redxn asistnce grp ea.h (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Bacterium described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for arginine deamination, esculin hydrolysis and beta glucosidase and negative for urease, catalase, sialidase and hyaluronidase. It can ferment amygdalin, lactose, salicin, cellobiose, trehalose and raffinose but not arabinose, glycerol, inulin, sorbitol, mannitol or ribose. S. anginosis is found in normal human urogenital and gastrointestinal tracts and is involved in opportunistic infections of abscesses.\nConcepts: Decreased riboflavin diet (Therapeutic or Preventive Procedure)\tHumidifiers, Artificial Airway (Household humidifier, device)\tStreptococcus anginosus (Andrewes and Horder 1906) Smith and Sherman 1938 (Approved Lists 1980) emend. Coykendall et al. 1987 (Streptococcus)\tLARGE INTESTINE, CECUM (Primitive midgut structure)\tSmall Cell Osteogenic Sarcoma (Osteosarcoma)", + "output": "Streptococcus anginosus (Andrewes and Horder 1906) Smith and Sherman 1938 (Approved Lists 1980) emend. Coykendall et al. 1987 (Streptococcus)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant mesenchymal tumor with skeletal muscle differentiation affecting the ovaries.\nConcepts: NURS HOMES (Health Care Related Organization)\tHeterotropia (Diagnosis/Diseases Component)\tnegative regulation of retinal ganglion cell axon guidance (regulation of retinal ganglion cell axon guidance)\tBUNION (Foot Deformities, Acquired)\tRhabdomyosarcoma of Ovary (Rhabdomyosarcoma)", + "output": "Rhabdomyosarcoma of Ovary (Rhabdomyosarcoma)" + }, + { + "input": "Definition: something described as acquired or learned responses which are regularly manifested in personality.\nConcepts: Stratum cinereum (Body Part, Organ, or Organ Component)\tFAC04106 (FKSI-DRS Version 4 Questionnaire Question)\tnitro compound (Organic Chemical)\tBehaviour pattern, NOS (Thesaurus of Psychological Index Terms)\tcarboxyamidotriazole (Organic Chemical)", + "output": "Behaviour pattern, NOS (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (typically serum or urine) to determine one or more of the group of hormones (e.g., aldosterone) and/or other products that are produced or degraded by the kidneys (e.g., renin); these reagents are mostly used in testing the function (metabolism) of the kidneys and/or related diseases (e.g., hypertension).\nConcepts: IVD Test Reagent/Kits, Immunoassay, Renal Metabolism (Medical Device)\tEC 3.5.-.- (Enzyme)\tPQL14-Get Sick Easily (Intellectual Product)\tGeneric Investigational New Animal Drug File (Intellectual Product)\tBRF2 Gene (TFIIIB Subunit Gene)", + "output": "IVD Test Reagent/Kits, Immunoassay, Renal Metabolism (Medical Device)" + }, + { + "input": "Definition: positive regulation of cellular metabolic process described as any process that activates or increases the frequency, rate or extent of tridecane metabolic process.\nConcepts: stage IIIB endometrial cancer (Neoplastic Process)\tBiobehavioral Determinants of Tobacco Use and Addiction (Research Activity)\tup-regulation of tridecane metabolic process (positive regulation of cellular metabolic process)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, HIV (Medical Device)\tDelayed ossification of vertebral epiphysis (Anatomical Abnormality)", + "output": "up-regulation of tridecane metabolic process (positive regulation of cellular metabolic process)" + }, + { + "input": "Definition: something described as provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.\nConcepts: MSSPEC (Qualitative Concept)\tTP53CP (TP63 gene)\tAdrenaline measurement (Hormone measurement)\tnetrin receptor activity (transmembrane signaling receptor activity)\tI 3 (Cell)", + "output": "I 3 (Cell)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O.\nConcepts: steroid 22-alpha hydroxylase activity (Molecular Function)\tHeadache, Vascular (Vascular Disorders, General and NEC)\tHyperconvex fingernails (Overcurvature of nail)\tERBB c.323G>A (EGFR gene mutation)\tHyperthermia Treatment (Thermoregulation intervention)", + "output": "steroid 22-alpha hydroxylase activity (Molecular Function)" + }, + { + "input": "Definition: Finding described as markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery.\nConcepts: Add (Ophthalmology Contact Lens)\t6-Item Orientation-Memory-Concentration Test (Clinical or Research Assessment Questionnaire)\tNo reflow phenomenon (Finding)\tFATMASS (Quantitative Concept)\th.fg/mL/(kg/m2) (Quantitative Concept)", + "output": "No reflow phenomenon (Finding)" + }, + { + "input": "Definition: something described as a species of bacteria within the phylum Proteobacteria consisting of gram-negative aerobic coccobacillus that are the causative agent of pertussis.\nConcepts: DT (Vaccines)\tnegative regulation of melanophore differentiation (regulation of melanocyte differentiation)\tIGFBP1 (Laboratory Procedure)\tHemophilus pertussis (Bordetella species)\tSmac Mimetic GDC-0152 (Organic Chemical)", + "output": "Hemophilus pertussis (Bordetella species)" + }, + { + "input": "Definition: something described as the anatomic site at which a medication or a vaccine is injected.\nConcepts: culture procedures tissue (LABORATORY IMMUNOLOGIC PROCEDURES)\textractions (removal technique)\tbrain; disease, Pick (Hereditary degenerative disease of central nervous system)\tpg.eq/ml/mg.eq (Measurement Unit Description)\tInjection Site (Spatial Concept)", + "output": "Injection Site (Spatial Concept)" + }, + { + "input": "Definition: Finding described as surgery or trauma <=4 weeks ago requiring treatment with general anesthesia\nConcepts: interleukin-14 production (cytokine production)\tMastectomy Patient (Surgery Patient)\tRecent surgery or trauma (Finding)\tTriangle of auscultation (Surface of subdivision of trunk)\tregulation of mitotic cell cycle phase transition (regulation of cell cycle phase transition)", + "output": "Recent surgery or trauma (Finding)" + }, + { + "input": "Definition: ceftiofur described as the hydrochloride salt form of ceftiofur, a semisynthetic, beta-lactamase-stable, broad-spectrum, third-generation cephalosporin with antibacterial activity. Ceftiofur binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.\nConcepts: PHYSICAL THERAPIST (Health Personnel)\tceftiofur hydrochloride (Antibiotic)\tDoderlein's bacillus (Bacterium)\tDrug Dose-Response Relationship (Toxicological Phenomena)\tSPRY4-IT1 (Gene or Genome)", + "output": "ceftiofur hydrochloride (Antibiotic)" + }, + { + "input": "Definition: Unit of concentration described as micro-international units per milliliter (concentration), divided by kilograms per meter squared (body mass index).\nConcepts: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs Clinical Distant Metastasis TNM Finding v8 (Finding)\tnegative regulation of calcidiol 1-monooxygenase activity (negative regulation of hormone biosynthetic process)\tu[iU]/mL/(kg/m2) (Quantitative Concept)\tcytochrome p 450 (Mixed Function Oxygenases)\tOptical Microscopy Shared Resource (Health Care Related Organization)", + "output": "u[iU]/mL/(kg/m2) (Quantitative Concept)" + }, + { + "input": "Definition: Methyltransferase described as PR domain zinc finger protein 2 (1718 aa, ~189 kDa) is encoded by the human PRDM2 gene. This protein is involved in both transcriptional regulation and the methylation of histone H3.\nConcepts: Red Blood Cells, Deglycerolized (Red blood cells, blood product)\tRetinoblastoma Protein-Binding Zinc Finger Protein RIZ (Biologically Active Substance)\tBody position, supine (Recumbent body position)\tpanicky (Panic attacks and disorders)\tOverweight (Body weight problem)", + "output": "Retinoblastoma Protein-Binding Zinc Finger Protein RIZ (Biologically Active Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as ATM interactor (823 aa, ~88 kDa) is encoded by the human ATMIN gene. This protein plays a role in the modulation of both cell survival and the response to DNA damage.\nConcepts: Sarcoglycan Complex (Cell Component)\tDNA-deoxyinosine deoxyribohydrolase activity (Genetic Function)\tHMGA2-RAD51B Fusion Protein (Fusion protein)\tFlavobacterium thalpophilum Holmes et al. 1983 (Flavobacterium genus)\tATM INteracting Protein (Amino Acid, Peptide, or Protein)", + "output": "ATM INteracting Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as duodenoscopes equipped with a television camera on the distal tip, typically in the form of a microchip (a charge-coupled device [CCD]). The image is electronically transmitted through wires in the endoscope for external processing, display, and recording of video images.\nConcepts: Video Duodenoscopes (Video Endoscopes)\tSector, Healthcare (Idea or Concept)\tHuman Subject (Study Subject)\tmed8xn educ.ndvdl ea.15min (Psychological Comfort Promotion)\tganglion trigeminal (Ganglia, Sensory)", + "output": "Video Duodenoscopes (Video Endoscopes)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of soluble proteins that are synthesized and secreted by muscle cells in response to muscle contraction and may drive autocrine, paracrine and endocrine signaling pathways in cells expressing myokine receptors.\nConcepts: IPAQ Long Last 7 Days Telephone Format Version - Walking Work Hours per Week (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tTwo Full Term Pregnancies (Number of Full Term Pregnancies)\tMyokine (Protein Family)\tdown regulation of anthocyanin biosynthetic process (Molecular Function)\tdate of first dose (Temporal Concept)", + "output": "Myokine (Protein Family)" + }, + { + "input": "Definition: Miscellaneous Occupation described as the group of professions that include ambulance drivers and attendants, bus drivers, driver/sales workers, heavy and tractor-trailer truck drivers, light truck or delivery service drivers, and taxi drivers and chauffeurs.\nConcepts: Representation (Conceptual Entity)\tZygomatic salivary gland (Experimental Organism Anatomical Concept)\tMotor Vehicle Operators (Miscellaneous Occupation)\tM\u00e9tronidazole (Organic Chemical)\tNever Marketed (Other Marketing Category)", + "output": "Motor Vehicle Operators (Miscellaneous Occupation)" + }, + { + "input": "Definition: something described as a directive to choose one of the options provided.\nConcepts: Dock/Battery Chargers (Electromechanical Devices)\tSelect One (Occupational Activity)\tGrowth Hormone Secreting Tumor of Pituitary (stage/type, pituitary tumor)\tNurse practitioner clinic (Manufactured Object)\tSYSTEM, X-RAY, ANGIOGRAPHIC (Fluoroscopic x-ray system)", + "output": "Select One (Occupational Activity)" + }, + { + "input": "Definition: regulation of carbohydrate biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.\nConcepts: Mixed Adenocarcinoma and Epidermoid Cell Carcinoma (Undifferentiated carcinoma)\tMulticenter Hemophilia Cohort Study (Research Activity)\tregulation of polysaccharide biosynthetic process (regulation of macromolecule biosynthetic process)\tPackage Cap Type Code (Container Cap Type Code)\t5,5-Dimethyl-2,4-oxazolidinedione (Oxazolidinediones)", + "output": "regulation of polysaccharide biosynthetic process (regulation of macromolecule biosynthetic process)" + }, + { + "input": "Definition: Pathologic Function described as any process in which infecting bacteria are clumped together by a host organism.\nConcepts: Reoperation (Therapeutic or Preventive Procedure)\tinduction of bacterial agglutination (Pathologic Function)\tCAMPYLOBACTER RECTUS (Bacterium)\tSubsequent Known Primary Melanoma(s) Found During the Follow-Up (Finding)\tAyvdc cnsltn ea.15min (Medicine, Ayurvedic)", + "output": "induction of bacterial agglutination (Pathologic Function)" + }, + { + "input": "Definition: Intellectual Product described as the proposition that a study sets out to support (or disprove); for example, \"blood pressure will be lowered by [specific endpoint] in subjects who receive the test product.\" See also null hypothesis.\nConcepts: Epstein-Barr Encoding Region in situ Hybridization (Laboratory Procedure)\tEssential Osteolysis (Disease or Syndrome)\tExpectation Maximization Algorithm (Intellectual Product)\tCYCAOXA (Crystal Growth Measurement)\tStudy Hypothesis (Hypothesis)", + "output": "Study Hypothesis (Hypothesis)" + }, + { + "input": "Definition: Cardiovascular finding described as the qualitative measurement of the severity of a prolapsing cardiac valve cusp.\nConcepts: solute carrier family 5 (sodium/glucose cotransporter), member 1 (Gene or Genome)\tBARS01-Global Clinical Assessment (BARS Questionnaire Question)\tFAC00840 (FACT-C Version 4 Questionnaire Question)\tCSPPSEV (Cardiovascular finding)\tcardiomyocyte cell fate commitment (cardiac cell fate commitment)", + "output": "CSPPSEV (Cardiovascular finding)" + }, + { + "input": "Definition: something described as any sign, symptom, disease, or other medical occurrence. EXAMPLE(S): death, back pain, headache, pulmonary embolism, heart attack, pregnancy, flu, broken bone, menstrual period, depression. NOTE(S): This condition may have been recalled by the subject or a caregiver or provided in their medical record.\nConcepts: Performed Medical Condition Result (Finding)\tPrecocious true puberty (Endocrine System Disorders, General, Polyglandular and NEC)\thyperglyceridaemia (Nutritional and Metabolic Diseases)\tCutaneous Squamous Cell Carcinoma of the Head and Neck cN2 TNM Finding v8 (Cutaneous Squamous Cell Carcinoma of the Head and Neck Clinical Regional Lymph Nodes TNM Finding v8)\tCalophyllums (Calophylleae)", + "output": "Performed Medical Condition Result (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as any monoclonal antibody directed against the cell surface glycoprotein CD8, regardless of the antibody type.\nConcepts: histone H3 acetylation at K27 (Molecular Function)\tpollen wall (external encapsulating structure)\tAnti-CD8 Monoclonal Antibody (Pharmacologic Substance)\tGrade 1 Pain In Extremity, CTCAE (Pain In Extremity, CTCAE)\tATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity (phosphatidylinositol kinase activity)", + "output": "Anti-CD8 Monoclonal Antibody (Pharmacologic Substance)" + }, + { + "input": "Definition: MPAI-4 Questionnaire Question described as mayo-Portland Adaptability Inventory-4 (MPAI-4) Memory: Problems learning and recalling new information.\nConcepts: Undulate clavicles (Abnormality of the clavicle)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Carrying 5-10 Lbs Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tDihydropyrimidine Dehydrogenase [NADP(+)] Ile543Val (DPYD Protein Variant)\tregulation of iron ion transmembrane transporter activity (Cell Function)\tMPAI109 (MPAI-4 Questionnaire Question)", + "output": "MPAI109 (MPAI-4 Questionnaire Question)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate.\nConcepts: manoyl oxide synthase activity (Molecular Function)\tChromosome pair 21 (Cell Component)\tIP4 binding (anion binding)\tHave Problem with Job or Education Because of Disease or Treatment (Intellectual Product)\tPredictive Value, Negative (Quantitative Concept)", + "output": "IP4 binding (anion binding)" + }, + { + "input": "Definition: Synaptic Membranes described as the membrane component of the postsynaptic specialization. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.\nConcepts: FAC023-I Get Support From My Friends (Intellectual Product)\tRemoval of lung, other than pneumonectomy; 2 lobes (Lobectomy)\tupregulation of hydrogen peroxide-induced intrinsic apoptotic signaling pathway (positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)\tpostsynaptic specialization membrane (Cell Component)\tTumor Regression Grade 3 (Mandard Grading System)", + "output": "postsynaptic specialization membrane (Cell Component)" + }, + { + "input": "Definition: Life Cycle Stages described as cessation of life; permanent cessation of all vital bodily functions.\nConcepts: Cancers, Muscle (Myomatous neoplasm)\tDeath NOS (Event)\tFMS-Related Tyrosine Kinase 3 Ligand Gene (Hematopoietic Factor Gene)\tleukocyte migration involved in inflammatory response (Cell Function)\tSuperfamily (Linnaean taxonomic ranks)", + "output": "Death NOS (Event)" + }, + { + "input": "Definition: something described as muscle strength exercisers designed to provide resistance to muscular contraction in the arms using a mechanism based on a system of pulleys and cables or levers. These exercisers usually consist of a stand-alone machine with weights stacked on top of each other or a hydraulic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars or pulley cables on which the user exerts force to counteract the exerciser resistance. Users can raise the lever bar handles or pull the cables to flex the elbow (i.e., arm curl) or push the lever up or down or pull the cables to extend the arm (i.e., arm extension). Arm strength exercisers are intended to improve muscle strength in the upper limbs (mainly biceps or triceps and wrist muscle), increase muscle size, enhance muscle endurance and power, and improve bone density.\nConcepts: Some or a little of the time (Clinical or Research Assessment Answer)\tArm Weight Lifting Machines (Manufactured Object)\tPituitary Stalk Lesion (Endocrine finding)\tNeutralizing Antibody (Antibody by function)\tEye movement desensitization and reprocessing (EMDR) therapy each 15 minutes (mental health counseling)", + "output": "Arm Weight Lifting Machines (Manufactured Object)" + }, + { + "input": "Definition: something described as mini-Mental State Examination 2 Standard Version (MMSE-2 Standard Version) What were those three words I asked you to remember: Word 3?\nConcepts: Intracellular canaliculus (CELL SURFACE AND ASSOCIATED STRUCTURES)\tPQL10-Feel Tired (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report Questionnaire Question)\tMMSE-2 Standard Version - Recall Word 3 (Intellectual Product)\tresponse to nutrient levels (response to extracellular stimulus)\tPropafenone product (Ketones)", + "output": "MMSE-2 Standard Version - Recall Word 3 (Intellectual Product)" + }, + { + "input": "Definition: Antilipidemic Agent described as a nonabsorbable copolymer of maleic acid and 18-carbon alpha-olefin with antilipidemic activity. Surfomer is reported to act by decreasing membrane hydrophobicity at the microvillus level, thus impairing the interaction between the intestinal membranes and intestinal cholesterol resulting in inhibition of intestinal cholesterol absorption.\nConcepts: Coloboma Of Iris, Choroid, And Retina (Disorder of eye)\tProtein Deficiencies (General nutritional disorders NEC)\tSURFOMER (Organic Chemical)\tAcamprosatum (Amino Acids)\tras Proto Oncogene Protein p21 (Amino Acid, Peptide, or Protein)", + "output": "SURFOMER (Organic Chemical)" + }, + { + "input": "Definition: something described as an emission spectrometer that generates a high-energy spark across an argon-filled gap between an electrode and a solid sample, causing emission of radiation from the excited sample surface and resulting in wavelengths characteristic of the elemental composition.\nConcepts: Arachis hypogaea IgE AB RAST Score (Immunoglobulin E measurement)\tIVD Test Reagent/Kits, Immunoassay, Allergy, Histamine (IVD Test Reagent/Kits, Immunoassay, Allergy)\tDEK (Amino Acid, Peptide, or Protein)\tOE Spectrometer (Research Device)\tPelvic arteriovenous malformation (Congenital Abnormality)", + "output": "OE Spectrometer (Research Device)" + }, + { + "input": "Definition: Quantitative Concept described as the volume of distribution associated with the terminal slope following intravascular administration, calculated using the observed value of the last non-zero concentration, divided by the dose.\nConcepts: Oligophrenia Phenylpyruvica (Autosomal recessive hereditary disorder)\tObserved Volume of Distribution Normalized by Dose (Observed Volume of Distribution)\tMONITOR, FETAL DOPPLER ULTRASOUND (Medical Device)\tSpecialized gonadal neopl. (Neoplasm by Morphology)\tintraoperative endocrine injury (endocrine disorders intraoperative complication)", + "output": "Observed Volume of Distribution Normalized by Dose (Observed Volume of Distribution)" + }, + { + "input": "Definition: something described as a subscale complement to the FACT-G developed specifically for evaluating the quality of life of colorectal cancer patients.\nConcepts: FACT-C (Intellectual Product)\tInterphalangeal jt of finger (Structure of interphalangeal joint region of finger)\tearly meiotic recombination nodule assembly (meiotic recombination nodule assembly)\tNot Known if ROS1 Rearrangement Analysis Was Performed (Finding)\tDNA replication origin (DNA Replication)", + "output": "FACT-C (Intellectual Product)" + }, + { + "input": "Definition: Long-acting sulfonamides described as a long-acting sulfanilamide antibiotic.\nConcepts: Environmental pollution (Physical environment)\tregulation of actomyosin structure organization (regulation of actin cytoskeleton organization)\tPain, Flank (Urinary symptoms)\tHodgkin's disease, stage II, childhood (stage, childhood Hodgkin lymphoma)\tisosulfamerazine (Organic Chemical)", + "output": "isosulfamerazine (Organic Chemical)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as rho GTPase-activating protein 45 (1136 aa, ~125 kDa) is encoded by the human ARHGAP45 gene. This protein is involved in the activation of Rho family GTPases.\nConcepts: Upper Respiratory Infection (Upper respiratory tract infections NEC)\tcardiac muscle cell action potential (Cell Function)\talaskan natives (Indigenous Population)\tbone (Anatomical set)\tARHGAP45 (GTPase-Activating Proteins)", + "output": "ARHGAP45 (GTPase-Activating Proteins)" + }, + { + "input": "Definition: activation of protein kinase activity described as any process that initiates the activity of an inactive protein histidine kinase.\nConcepts: Alpha Thalassemia X-Linked Mental Retardation Syndrome (Syndrome)\ttopological DNA entrapment activity (Genetic Function)\tHIGH PRESSURE LIQUID CHROMATOGRAPHY, METHAMPHETAMINE (Medical Device)\tactivation of protein histidine kinase activity (activation of protein kinase activity)\tStage IVB Thyroid Gland Follicular Carcinoma AJCC v8 (Neoplastic Process)", + "output": "activation of protein histidine kinase activity (activation of protein kinase activity)" + }, + { + "input": "Definition: Antifungal Agents described as a synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections.\nConcepts: methanol catabolic process (methanol metabolic process)\tOriconazole (Antibiotics, Antifungal)\tDetoxPC adjuvant (Vaccine Adjuvant)\tActivation of Membrane Attack Complex (Cell Function)\tAllopathic & Osteopathic Physicians; Family Medicine, Geriatric Medicine (Professional or Occupational Group)", + "output": "Oriconazole (Antibiotics, Antifungal)" + }, + { + "input": "Definition: something described as a gastric adenocarcinoma that arises from the proximal part of the stomach.\nConcepts: Boundary Maintenances, Ethnic (Group Attribute)\tProximal Gastric Adenocarcinoma (Gastric Adenocarcinoma)\tGiant Fibroadenoma of Breast (Neoplastic Process)\tAutologous Ovarian Tumor Cell Lysate-Pulsed Dendritic Cell Vaccine (Dendritic Cell Vaccine)\tExperimentalUnit.identifier (Intellectual Product)", + "output": "Proximal Gastric Adenocarcinoma (Gastric Adenocarcinoma)" + }, + { + "input": "Definition: Functional Concept described as exhibit, present, or demonstrate for viewing.\nConcepts: Motor (Device Component or Accessory)\tGastric Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Gastric Cancer Pathologic TNM Finding v7)\tDNA, repair (Biochemical Processes)\tDisplay - arrangement (Functional Concept)\tI get support from my friends question (Findings-Based Question)", + "output": "Display - arrangement (Functional Concept)" + }, + { + "input": "Definition: Research Activity described as investigation in which data are collected from a number of subjects over a long period of time (a well-known example is the Framingham study).\nConcepts: long-term study (Research Activity)\tshunt 2+ subst njxn ea.njxn (Injection procedure)\tup-regulation of cholesterol absorption (positive regulation of intestinal lipid absorption)\tPASI01-Low Extrem (L): Sum X Area X 0.4 (PASI Clinical Classification Question)\tnegative regulation of peripheral B cell anergy (negative regulation of B cell mediated immunity)", + "output": "long-term study (Research Activity)" + }, + { + "input": "Definition: something described as treatment of an area of Barrett's-affected tissue in the esophagus with heat energy that is delivered through an endoscope.\nConcepts: up-regulation of signal transduction involved in mitotic G2/M transition DNA damage checkpoint (Cell Function)\tMENOMETRORRHAGIA (Metrorrhagia)\tDecontaminants, Chemical Neutralization (Substance)\tAblation for Barrett's Esophagus (Ablation)\tBilateral breast hypoplasia (Congenital hypoplasia of breast)", + "output": "Ablation for Barrett's Esophagus (Ablation)" + }, + { + "input": "Definition: something described as a group of structures defined by connectivity, namely, structures that receive axons from the olfactory bulb. They include the anterior olfactory nucleus, the olfactory tubercle, the rostral part of the medial amygdalar nucleus (anterior cortical nucleus of the amygdala), and structures in the anterior part of the parahippocampal gyrus, namely, the piriform area, most of the periamygdalar area, and the rostral part of the entorhinal area ( Price-1990 ). Note that some authors have regarded the olfactory bulb itself as the primary olfactory area and the areas to which it projects as secondary ( Anthoney-1994 ).\nConcepts: lateral olfactory area (Cerebral cortex)\tCARCINOMA, SQUAMOUS CELL, MALIGNANT (Papillary and Squamous Cell Neoplasms)\tL-3-hydroxyacyl CoA dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tstrand displacement (DNA metabolic process)\tDE (Region of United States of America)", + "output": "lateral olfactory area (Cerebral cortex)" + }, + { + "input": "Definition: Recommendation and/or prescription services with or without ICD diagnosis described as prescribing a Schedule II controlled substance(s). Service is billed as a no-charge item.\nConcepts: 9p21 (Chromosome band)\tEndophyte (Fungus)\tschd.II ctrld subst Rx nc (Recommendation and/or prescription services with or without ICD diagnosis)\tmunchausen syndrome (Physical & Psychosomatic Disorders)\tCongenital adrenal gland hypoplasia (Adrenal cortical hypofunction)", + "output": "schd.II ctrld subst Rx nc (Recommendation and/or prescription services with or without ICD diagnosis)" + }, + { + "input": "Definition: Immunology procedure described as a process used to identify cells, based on the types of antigens or markers on the surface of the cell. This process is used to diagnose specific types of leukemia and lymphoma by comparing the cancer cells to normal cells of the immune system.\nConcepts: Immunophenotyping (Cell marker analysis)\tEPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 36 (X-linked infantile spasms)\tCD1(ICR) (Mice, Inbred Strains)\tcell wall modification involved in multidimensional cell growth (Cell Function)\tRenal Dysplasia (Disease or Syndrome)", + "output": "Immunophenotyping (Cell marker analysis)" + }, + { + "input": "Definition: something described as pulse oximetry utilizing near infrared spectroscopy (NIRS) is commonly used in modern ICUs to provide a continuous measure of hemoglobin saturation and systemic oxygenation.\nConcepts: Disintegration per Second (Unit of Radioactive Decay)\tDSG3AB (Immunologic Tests)\tCerebral oxygen saturation (Organ or Tissue Function)\tFACT-L Version 4 - I Have Pain (FACT-L Version 4 Questionnaire Question)\tSerratia rubidaea (Stapp 1940) Ewing et al. 1973 (Bacterium)", + "output": "Cerebral oxygen saturation (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a unitless index of airway hyperreactivity used to evaluate changes in the shape of the airflow pattern of a subject using a whole-body flow plethysmograph.\nConcepts: Difficulty Explaining Illness to Others (Clinical or Research Assessment Question)\tPENH (Finding)\tBenign Brenner Tumor of Ovary (Benign Neoplasm)\tpyruvate:NADP+ 2-oxidoreductase (Molecular Function)\tTimothy syndrome type 1 (Conduction disorder of the heart)", + "output": "PENH (Finding)" + }, + { + "input": "Definition: Medical Device described as an ear, nose, and throat drug administration device is one of a group of ear, nose, and throat devices intended specifically to administer medicinal substances to treat ear, nose, and throat disorders. These instruments include the powder blower, dropper, ear wick, manual nebulizer pump, and nasal inhaler.\nConcepts: At risk for latex allergy response (At risk for physiological dysfunction)\tEndodontia (Procedure on tooth)\tDROPPER, ENT (Medical Device)\tOtological Toxicity, Drug-Related (Disease or Syndrome)\tMicrogram per Animal (Quantitative Concept)", + "output": "DROPPER, ENT (Medical Device)" + }, + { + "input": "Definition: Organism Function described as any process that activates or increases the frequency, rate or extent of arabinoxylan-containing compound catabolic process.\nConcepts: Carcinoma, Embryonal (Neoplastic Process)\tMaterial Integrity Problem (Device physical property issue)\tBorderline Ovarian Clear Cell Adenofibroma with Intraepithelial Carcinoma (Neoplastic Process)\tDate Time of Angina Pectoris Prompting Medical Attention (Temporal Concept)\tpositive regulation of arabinoxylan-containing compound catabolic process (Organism Function)", + "output": "positive regulation of arabinoxylan-containing compound catabolic process (Organism Function)" + }, + { + "input": "Definition: Intestinal edema described as fluid retention and edema in the intestine caused by a compromised lymphatic system.\nConcepts: Drosophila melanogasters (Eukaryote)\tExocrine and Endocrine Pancreatic Cancer pTX TNM Finding v7 (Exocrine and Endocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v7)\tIntestinal lymphedema (Disease or Syndrome)\tHemorrhage of digestive system (Signs and Symptoms, Digestive)\tTumor of retroperitoneum (Disorder of retroperitoneal region, excluding major organs)", + "output": "Intestinal lymphedema (Disease or Syndrome)" + }, + { + "input": "Definition: FACT-B Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Breast Version 4 - Emotional Well-Being: I feel nervous.\nConcepts: regulation of cellular response to X-ray (regulation of response to stimulus)\tOncostatin A (blood coagulation studies)\tFAC005-I Feel Nervous (FACT-B Version 4 Questionnaire Question)\tprocollagen-proline, 2-oxoglutarate-4-dioxygenase complex location, alpha(III) type (Cell Component)\tTestosterone Vaginal Cream (Therapeutic Testosterone)", + "output": "FAC005-I Feel Nervous (FACT-B Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Regulatory Assessment described as the healthcare provider or setting must have the ability to carry out a particular clinical activity, such as administer a particular treatment, diagnose a particular disease, or recognize a particular adverse event.\nConcepts: myocarditis; rheumatic fever (Rheumatic fever with heart involvement)\tBe Able To Perform a Clinical Activity (Health Care Activity)\tpositive regulation of growth factor dependent skeletal muscle satellite cell proliferation (positive regulation of skeletal muscle satellite cell proliferation)\tHypopharyngeal Aspect of the Aryteno-Epiglottic Fold (Head and Neck Part)\tCarcinoma simplex (ADENOMAS AND ADENOCARCINOMAS)", + "output": "Be Able To Perform a Clinical Activity (Health Care Activity)" + }, + { + "input": "Definition: protein disulfide oxidoreductase activity described as catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione.\nConcepts: MGC33046 (PDCD4 gene)\tMaterial Deformation (Material Integrity Problem)\tFatty Acid Binding Protein 1 (Laboratory Procedure)\tglutathione oxidoreductase activity (Molecular Function)\tIVD Test Reagent/Kits, Clinical Chemistry, Control, Serum, Triglyceride (Medical Device)", + "output": "glutathione oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as tapered cylindrical ends that are attached to pipettors and that are designed for the uptake, transfer, and dispensing of a volume of liquid. Pipette tips can have various features such as non-sterile, pre-sterilized, and filtered. They can be made of plastic or glass and are usually disposable.\nConcepts: T2-induced deoxynucleotide kinase activity (Molecular Function)\tPipette Tips (In Vitro Diagnostics and Laboratory Equipment)\tClosed Ecological Systems (Environment, Controlled)\tTRH wt Allele (Gene or Genome)\t5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-((acetyloxy)methyl)-7-((cyanoacetyl)amino)-8-oxo-, monosodium salt, (6R-trans)- (First generation cephalosporin)", + "output": "Pipette Tips (In Vitro Diagnostics and Laboratory Equipment)" + }, + { + "input": "Definition: Gnaphalieae described as a plant genus of the family ASTERACEAE. Members contain CHALCONE, helichrysetin, arenarin, and flamin.\nConcepts: UDP-D-apiose anabolism (Molecular Function)\tHelichrysums (Gnaphalieae)\tOcclusion of bile duct (cancer-related problem/condition)\tCongenital, Hereditary, and Neonatal Diseases and Abnormalities (Diseases)\tChemodenervation (NERVES: INJECTIONS AND IMPLANTATIONS)", + "output": "Helichrysums (Gnaphalieae)" + }, + { + "input": "Definition: D [Preparations] described as the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis.\nConcepts: Postweaning Multisystemic Wasting Syndrome, Porcine (Swine Diseases)\tdorzolamide HCl (Ophthalmic Intraocular Pressure Lowering Agents, Other)\tGlomerulonephritides (Inflammation of specific body systems)\tpill form of medicine (Oral drug preparation, NOS)\tWorst Severity Past Seven Days Hiccups (Clinical or Research Assessment Question)", + "output": "dorzolamide HCl (Ophthalmic Intraocular Pressure Lowering Agents, Other)" + }, + { + "input": "Definition: something described as l antigen family member 3 (143 aa, ~15 kDa) is encoded by the human LAGE3 gene. This protein has no known function.\nConcepts: CD246 Gene Rearrangement Analysis (molecular diagnostics gene rearrangement)\tchromosome 20q duplication syndrome (Disease or Syndrome)\tLiver Stem Cell (Cell)\tLAGE3 (Amino Acid, Peptide, or Protein)\tregulation of translational termination (Cell Function)", + "output": "LAGE3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of the Bromodomain and Extra-Terminal (BET) family of proteins, with potential antineoplastic activity. Upon oral administration, the BET inhibitor GS-5829 binds to the acetylated lysine recognition motifs in the bromodomains of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histones. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of proliferation in BET-overexpressing tumor cells. BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C126640\" active clinical trials using this agent.\nConcepts: Therapy, Virtual Reality (Therapeutic or Preventive Procedure)\tGS5829 (Pharmacologic Substance)\tCGF (Organization)\tDiluent Excipient (Biomedical or Dental Material)\tIntracranial Artery Aneurysm Bifurcation Stents (Medical Device)", + "output": "GS5829 (Pharmacologic Substance)" + }, + { + "input": "Definition: Inhibitory Concentration Test described as a measurement of titer of a viral organism or biological/biochemical reaction that has been exposed to a concentration of a specific drug expected to produce 95% inhibition of the standard growth of the viral organism, or of a reaction.\nConcepts: leaf shaping (Morphogenesis)\tPrevious Company Name (Company)\t95 Percent Maximal Inhibitory Concentration Subject Result Measurement (Inhibitory Concentration Test)\tNatriuretic Agents (Physiological Effects of Drugs)\tPlate-reader Artifact (Faulty Instrument or Use of Instrument Artifact)", + "output": "95 Percent Maximal Inhibitory Concentration Subject Result Measurement (Inhibitory Concentration Test)" + }, + { + "input": "Definition: Finding described as a finding based on laboratory test results that indicate a decrease in number of platelets in a blood specimen.\nConcepts: LDA (Research Device)\tGene sequencing (Molecular Genetic Technique)\tPlatelet Count Decreased, CTCAE (Finding)\tcoryneform bacterium (Bacteria)\tGLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 5 (Mental Retardation)", + "output": "Platelet Count Decreased, CTCAE (Finding)" + }, + { + "input": "Definition: Paraesthesias and dysaesthesias described as a sensation of stinging or heat, not necessarily accompanied by redness or physical signs of irritation.\nConcepts: burning; sensation (Sensory Manifestations)\tAbscess NOS (Disease)\tHAMDS1TC (CDISC Questionnaire Terminology)\tcore primosome complex location (Cell Component)\tmitochondrial 5'-adenylyl sulfate transmembrane transport (Cell Function)", + "output": "burning; sensation (Sensory Manifestations)" + }, + { + "input": "Definition: enzyme activator activity described as increases the activity of rubisco by the removal of otherwise inhibitory sugar phosphates: RuBP, and in some plants, 2-carboxyarabinitol 1-phosphate.\nConcepts: Low Affinity Interleukin 3 Receptor Alpha (Receptor)\tDiabetes Mellitus, Brittle (Disorder of endocrine pancreas)\tFtsB-FtsL complex (divisome complex)\tNFKB Inhibitor Epsilon Gene (Signaling Pathway Gene)\tribulose-1,5-bisphosphate carboxylase/oxygenase activator activity (enzyme activator activity)", + "output": "ribulose-1,5-bisphosphate carboxylase/oxygenase activator activity (enzyme activator activity)" + }, + { + "input": "Definition: Laboratory or Test Result described as a blood concentration of prostate specific antigen less than 15 ng/mL.\nConcepts: PSA Level Less than 15 (PSA Level Finding)\tENZYME IMMUNOASSAY, NON-RADIOLABELED, TOTAL THYROXINE (Medical Device)\t(-)-secologanin catabolism (beta-glucoside catabolic process)\tTransient hypogammaglobulinaemia (Hypogammaglobulinemia)\tLocally Advanced Lip and Oral Cavity Carcinoma (Neoplastic Process)", + "output": "PSA Level Less than 15 (PSA Level Finding)" + }, + { + "input": "Definition: Microbacteriaceae described as a genus of Gram positive, coryneform bacterium assigned to the phylum Actinobacteria and the family Microbacteriaceae.\nConcepts: 6PGD activity (Molecular Function)\tRadiation dosimetry (Radiation)\tIVD Test Reagent/Kits, Serology, Parasite, Toxoplasma gondii, IgA Antibody (IVD Test Reagent/Kits, Serology, Parasite, Toxoplasma gondii, Antibody)\tLEIFSONIA (Microbacteriaceae)\tBranchiootorenal syndrome (Multiple malformation syndrome with facial defects as major feature)", + "output": "LEIFSONIA (Microbacteriaceae)" + }, + { + "input": "Definition: Plant described as a plant genus of Asparagaceae.\nConcepts: Chronic Cervicitis (Pelvic Inflammatory Disease)\tMuscari Mill. (Plant)\tImaging System (Imaging Device)\tLily, Water (Nymphaeaceae)\tAnterior Translated Sacrum (Somatic dysfunction of sacral spine)", + "output": "Muscari Mill. (Plant)" + }, + { + "input": "Definition: Triazenes described as a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.\nConcepts: Left atrium systolic volume (Left atrium cavity size)\tGRAM-NEGATIVE MICROAEROPHILIC BACILLUS (Bacterium)\tPositive pathergy test (Abnormality of skin physiology)\td cells (Gastric mucosa)\t5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (Organic Chemical)", + "output": "5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (Organic Chemical)" + }, + { + "input": "Definition: something described as enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid.\nConcepts: GVE (Body Part, Organ, or Organ Component)\tNephropathy due to Amphotericin (Disease or Syndrome)\tLEC01-Combat/Exp to War-Zone: Job (LEC-5 Standard Version Questionnaire Question)\tbetaine transmembrane transporter activity (quaternary ammonium group transmembrane transporter activity)\tSchool Age Child (Age Group)", + "output": "betaine transmembrane transporter activity (quaternary ammonium group transmembrane transporter activity)" + }, + { + "input": "Definition: Health Risk Assessment described as assessment of an individual's specific predispositions for hereditary breast cancer, such as presence of a gene mutation.\nConcepts: Intellectual Developmental Disorder with Cardiac Arrhythmia (Disease or Syndrome)\tMMSE - Keep Subtracting 7 Step 4 (Intellectual Product)\talpha-pinene lyase activity (intramolecular lyase activity)\tNU (Population Group)\tRisk Assessment for Hereditary Breast Cancer (Health Care Activity)", + "output": "Risk Assessment for Hereditary Breast Cancer (Health Care Activity)" + }, + { + "input": "Definition: purine nucleotide binding described as interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate.\nConcepts: Body, Cell (Cell Component)\tALBUMIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tlipid antigen binding (antigen binding)\tadenyl nucleotide binding (Molecular Function)\tNeoplasm;skin (Mass of skin)", + "output": "adenyl nucleotide binding (Molecular Function)" + }, + { + "input": "Definition: Alkenes described as compounds with triple bonds to each side of a double bond. Many of these are CYTOTOXINS and are researched for use as CYTOTOXIC ANTIBIOTICS.\nConcepts: self efficacy (Self Concept)\tMitochondrial Delta-1-Pyrroline 5-Carboxylate Dehydrogenase (Enzyme)\tEnediynes (Organic Chemical)\tH2AC8 gene (Histone H2A Gene)\tmitotic cell cycle phase (Cell Cycle Phase)", + "output": "Enediynes (Organic Chemical)" + }, + { + "input": "Definition: something described as a carcinoma that arises from the pancreas showing either extensive mucin accumulation and acinar neoplastic cells or a mixture of columnar or signet-ring cells and acinar neoplastic cells.\nConcepts: Mixed Acinar-Ductal Carcinoma of the Pancreas (Neoplastic Process)\tAnalyzers, Laboratory, Blood Gas/pH/Electrolyte (Analyzers, Laboratory)\tSimulators, Temperature (Simulators)\tmyb Gene (Proto-Oncogenes)\tregulation of axon diameter (regulation of axonogenesis)", + "output": "Mixed Acinar-Ductal Carcinoma of the Pancreas (Neoplastic Process)" + }, + { + "input": "Definition: anatomical structure development described as the progression of the fungiform papilla over time, from its formation to the mature structure. The fungiform papilla is a mushroom-shaped papilla of the tongue.\nConcepts: Vallecula cerebelli (Head and Neck Part)\tNCI CTEP SDC Lung, Mediastinal and Pleural Neoplasm, Miscellaneous Sub-Category Terminology (Intellectual Product)\tsubject trial contact (Functional Concept)\tfungiform papilla development (anatomical structure development)\tChildhood Teratocarcinoma of the Testis (Childhood Testicular Non-Seminomatous Germ Cell Tumor)", + "output": "fungiform papilla development (anatomical structure development)" + }, + { + "input": "Definition: Mammal described as dogs that are trained to perform practical tasks, as opposed to PETS or companion dogs.\nConcepts: Dog, Working (Animals, Domestic)\tJoints and Fascia Partial GvHD Response (Partial Response in GvHD)\tStage IIA Bone Cancer (Neoplastic Process)\tOABQ02-Accidental Loss of Urine (Intellectual Product)\tCopti (Coptidoideae)", + "output": "Dog, Working (Animals, Domestic)" + }, + { + "input": "Definition: Hormone described as a naturally occurring glucocorticoid that has been used in replacement therapy for ADRENAL INSUFFICIENCY and as an anti-inflammatory agent. Cortisone itself is inactive; it is converted in the liver to the active metabolite HYDROCORTISONE.\nConcepts: cortisones (Glucocorticoids, Systemic)\tSRCs (Cell)\tUHDRS 1999 Version - Diagnosis Confidence Level (UHDRS 1999 Version Clinical Classification Question)\tCD3EAP (Gene or Genome)\tLY3499446 (Pharmacologic Substance)", + "output": "cortisones (Glucocorticoids, Systemic)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the extent to which an individual is bothered by upset stomach and/or indigestion.\nConcepts: Bothered by Stomach Upset and/or Indigestion (Clinical or Research Assessment Question)\tNCI Metathesaurus Code (Concept Unique Identifier)\tLACTOBACILLUS VAGINALIS (Bacterium)\tOptic Fissure (Other Embryologic Structure)\tNSA0110 (Intellectual Product)", + "output": "Bothered by Stomach Upset and/or Indigestion (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as an identifier that describes the relative position of palpable masses data within a series.\nConcepts: Grade 5 Infantile Apnea, Adverse Event (Finding)\tlinkage map (Molecular Genetic Technique)\tChromosome 10, monosomy 10p (Disease or Syndrome)\tPMSEQ (Intellectual Product)\tLymphoblasts/Leukocytes (Laboratory Procedure)", + "output": "PMSEQ (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + homoserine lactone.\nConcepts: Parainfluenza virus, NOS (Paramyxovirus, NOS)\tdopaminergic synapse (Synapses)\tUSF Transcription Factors (Basic Helix-Loop-Helix Transcription Factors)\tS-adenosyl-L-methionine alkyltransferase (Molecular Function)\tsecondary active sulphate transmembrane transporter activity (active ion transmembrane transporter activity)", + "output": "S-adenosyl-L-methionine alkyltransferase (Molecular Function)" + }, + { + "input": "Definition: Phosphotransferases described as a group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group acceptor. EC 2.7.3.\nConcepts: Kabyle Language (Berber language)\tDiaphragmatic eventration (Soft tissue lesion)\tBISMARCK BROWN Y (Indicator, Reagent, or Diagnostic Aid)\tmonalizumab (Monoclonal Antibodies)\tPHOSPHOTRANSFERASES NITROGENOUS (Amino Acid, Peptide, or Protein)", + "output": "PHOSPHOTRANSFERASES NITROGENOUS (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Pathologic Function described as loose and sagging skin often associated with loss of skin elasticity.\nConcepts: Amma therapy each 15 minutes (Oriental massage)\tStudy Day of Cardiovascular System Findings (Temporal Concept)\tinhibition of ornithine breakdown (negative regulation of cellular amino acid metabolic process)\tSagging, redundant skin (Pathologic Function)\tCDISC Breast Cancer Therapeutic Area User Guide Version 1.0 (Intellectual Product)", + "output": "Sagging, redundant skin (Pathologic Function)" + }, + { + "input": "Definition: MMSE Functional Test Question described as mini-Mental State Examination - What is the year?\nConcepts: monomers (Drug or Chemical by Structure)\tMMS1-What Is the Year (Intellectual Product)\tCatchment Area, Health (Geographic Area)\tLarge for Dates Baby (Gestational age and weight conditions)\t(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione (Chemical categorised functionally)", + "output": "MMS1-What Is the Year (Intellectual Product)" + }, + { + "input": "Definition: Biologically Active Substance described as beclin-2 (431 aa, ~48 kDa) is encoded by the human BECN2 gene. This protein is involved in both autophagy and the catabolism of G protein-coupled receptors.\nConcepts: Blood antidiuretic hormone abnormal NOS (Finding)\tBeclin-2 (Biologically Active Substance)\tGlobal developmental delay, lung cysts, overgrowth, Wilms tumor syndrome (Global developmental delay)\tExperimental Organism Keratinizing Cyst (Experimental Organism Finding)\tHDAC Inhibitor OKI-179 (Organic Chemical)", + "output": "Beclin-2 (Biologically Active Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as a peptide vaccine consisting of amino acids 65 through 76 derived from the tumor suppressor protein Von Hippel-Lindau (VHL) with a glycine substitution at position 74. As a cancer vaccine, VHL-59: 65-76(V74G) may stimulate a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing this VHL mutant protein.\nConcepts: MOELTM (Temporal Concept)\tVHL-42: 65-76(V74G) (Immunologic Factor)\tATPase, Ca++ Dependent, Slow-Twitch, Cardiac Muscle-2 Gene (Gene or Genome)\tAdapter Protein Gene (Gene or Genome)\tundef.Wstrn hrb&ntrl subst l (Western herbs and natural substances letter E)", + "output": "VHL-42: 65-76(V74G) (Immunologic Factor)" + }, + { + "input": "Definition: Tissue described as a thin layer of fibrous tissue capable of stretching and contracting. It is part of the tunica media of the blood vessels.\nConcepts: NCCN-FACT FBLSI-18 Version 2 - I Feel Ill (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)\tStimulators, Gingival (Stimulators, Mechanical, Dentistry)\tEpithelium of choroid plexus of fourth ventricle (Subdivision of epithelium of choroid plexus)\tExternal Elastic Membrane (Tissue membrane)\tAllergen product (Allergens)", + "output": "External Elastic Membrane (Tissue membrane)" + }, + { + "input": "Definition: something described as absence or underdevelopment (hypoplasia) of the middle phalanx of the little (5th) finger.\nConcepts: downregulation of conjugation (Cell Function)\tScribble, Drosophila, Homolog of Gene (Gene or Genome)\tup regulation of GTP binding (regulation of GTP binding)\tAbsent/underdeveloped middle bone of pinky finger (Hand)\tcytosolic proteasome regulatory particle, lid subcomplex (Cell Component)", + "output": "Absent/underdeveloped middle bone of pinky finger (Hand)" + }, + { + "input": "Definition: Nephroblastoma described as wilms tumor that is found in one kidney and can be completely removed with surgery.\nConcepts: Subtotal pancreatectomy (procedure) [Ambiguous] (Partial excision)\tFast-growing nails (Finding)\tstage I Wilm's tumor (Nephroblastoma)\tPentamidine-containing product (Drug allergens)\tPrimary mediastinal large B-cell lymphoma refractory (Neoplastic Process)", + "output": "stage I Wilm's tumor (Nephroblastoma)" + }, + { + "input": "Definition: Abnormal circulating asparagine concentration described as a decreased amount of asparagine in the blood.\nConcepts: Strobilurin (Hazardous or Poisonous Substance)\tDecreased blood asparagine concentration (Abnormal circulating asparagine concentration)\tOvarian Cancer and Primary Peritoneal Carcinoma pT3a TNM Finding v7 (Finding)\tStratum Intermedium (Head and Neck Part)\tLiquid crystals (Manufactured Materials)", + "output": "Decreased blood asparagine concentration (Abnormal circulating asparagine concentration)" + }, + { + "input": "Definition: negative regulation of response to DNA damage stimulus described as any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage.\nConcepts: PSAF (Cell marker analysis)\tdown regulation of DNA damage response, signal transduction by p53 class mediator (negative regulation of response to DNA damage stimulus)\tinhibition of kojic acid biosynthesis (Molecular Function)\tMETHYLTHYMOL BLUE, CALCIUM (Indicator, Reagent, or Diagnostic Aid)\tGrade 1 Anosmia (Finding)", + "output": "down regulation of DNA damage response, signal transduction by p53 class mediator (negative regulation of response to DNA damage stimulus)" + }, + { + "input": "Definition: Bacterium described as a genus of gram-positive, anaerobic bacteria in the order CLOSTRIDIALES and phylum FIRMICUTES. This genus is known for the type species Neglecta timonensis which was discovered in the stool of a patient with DIABETES MELLITUS, TYPE 2.\nConcepts: Neglecta (Ruminococcaceae)\tHAQ0235 (HAQ-DI Without VAS Questionnaire Question)\tanti-Ep-CAM monoclonal antibody ING-1 (Monoclonal Antibodies)\tformylkynurenine formamidase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tregulation of oomycete sporangium development (Biologic Function)", + "output": "Neglecta (Ruminococcaceae)" + }, + { + "input": "Definition: Drug Metabolism described as metabolic processes that utilize folic acid (as tetrahydrofolate) as a carbon unit donor.\nConcepts: metaplasia; apocrine (Epithelial metaplasia)\tGalunisertib (Antineoplastic Enzyme Inhibitor)\tVaginal Cancer pT3 TNM Finding v7 (Finding)\tHyperkeratosis, gingival (Abnormality of the gingiva)\tFolic Acid Metabolic Process (water-soluble vitamin metabolic process)", + "output": "Folic Acid Metabolic Process (water-soluble vitamin metabolic process)" + }, + { + "input": "Definition: Gene or Genome described as human CEP170B wild-type allele is located in the vicinity of 14q32.33 and is approximately 31 kb in length. This allele, which encodes centrosomal protein of 170 kDa protein B, may play a role in microtubule organization.\nConcepts: MTCP1 wt Allele (MTCP1 gene)\tBlasts 6-25 Percent of Bone Marrow Nucleated Cells (Laboratory or Test Result)\tFamilial Cancer Risk Shared Resource (Health Care Related Organization)\tDAD1 wt Allele (Gene or Genome)\tKIAA0284 (Gene or Genome)", + "output": "KIAA0284 (Gene or Genome)" + }, + { + "input": "Definition: Contrast Media described as contrast media used to enhance the differences in signal intensity emitted from tissues during ultrasonic imaging procedures. Ultrasound contrast agents typically consist of consist of microbubbles of gas (e.g., air, nitrogen, perfluorocarbon) encapsulated by a shell that increase the reflectivity of fluids (e.g., blood) or tissues, enhancing the ultrasound image. Ultrasound contrast microbubble shells are composed of various materials, including albumin, galactose, or lipids. The composition of the shell and the type of gas within the microbubble determine its degree of elasticity, which affects how the microbubble responds to the acoustic energy in the ultrasound beam. Ultrasound contrast media typically require product-specific preparation prior to administration. Some agents are delivered in powder form that is reconstituted with sterile saline, while other agents are in liquid form and require either hand agitation or mechanical agitation using a specialized machine.\nConcepts: Hydrology (Ecology)\tUltrasound Contrast Media (Ultrasound contrast media)\tSUSTRF (Start Relative to Reference Period)\tQS-BARS TESTCD (Intellectual Product)\tEMO1-Total Stimuli Response Incorrect (Intellectual Product)", + "output": "Ultrasound Contrast Media (Ultrasound contrast media)" + }, + { + "input": "Definition: Micronesia described as an island group in the North Pacific Ocean, about three-quarters of the way from Hawaii to Indonesia.\nConcepts: MICRONESIA, FEDERATED STATES OF (Australasian country)\tProtein Altering Variant (Genetic Function)\tLowry MacLean syndrome (Hereditary Connective Tissue Disorder)\tresponse to methylglyoxal (Cell Function)\tRifaxidin (rifamycins)", + "output": "MICRONESIA, FEDERATED STATES OF (Australasian country)" + }, + { + "input": "Definition: Gene or Genome described as the human MIRLET7F2 wild-type allele is located in the vicinity of Xp11.22 and is 82 bases in length. This allele, which encodes MIRLET7F2 RNA, plays a role in lung cancer.\nConcepts: frequencies (Time patterns)\tPortion of urine (Body Substance)\tcardiac computerized tomographic angiography (angiogram)\thsa-let-7f-2 (MIRLET7F2 gene)\tPeriarticular soft-tissue mass (Finding)", + "output": "hsa-let-7f-2 (MIRLET7F2 gene)" + }, + { + "input": "Definition: Primary malignant neoplasm described as a rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized by the presence of both mucin and non-mucin producing cells.\nConcepts: heart formation (Organogenesis)\tConcentrate for Dip Emulsion Dosage Form (Concentrated Solution Dosage Form)\tProtocol Element (Intellectual Product)\tLymphocyte Function (Lymphocyte Cell Biology)\tIndeterminate Bronchioloalveolar Carcinoma (Malignant adenomatous neoplasm - category)", + "output": "Indeterminate Bronchioloalveolar Carcinoma (Malignant adenomatous neoplasm - category)" + }, + { + "input": "Definition: Minerals described as an allotropic form of carbon that is used in pencils, as a lubricant, and in matches and explosives. It is obtained by mining and its dust can cause lung irritation.\nConcepts: Natural graphite (N [Preparations])\tAntiphospholipid Antibody (Immunologic Factor)\tCachexia, NOS (Other Growth)\tPuffs (Unit dose)\tCC-MELD TESTCD (Intellectual Product)", + "output": "Natural graphite (N [Preparations])" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective answer of mild agreement regarding the importance of something.\nConcepts: Numbness (SENSORY FUNCTIONS AND DYSFUNCTIONS)\tabsteigendes Retikularissystem (Body System)\tSomewhat Important (Finding)\tProduction of Individual Vaccine Component (Preparation)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 3 Low Birth Weight (Intellectual Product)", + "output": "Somewhat Important (Finding)" + }, + { + "input": "Definition: Percent Stromal Tissue described as the percentage of the analysis area that is represented by stromal tissue.\nConcepts: TTE (Data Set)\tanalysis area percentage stroma (Quantitative Concept)\tIntellectual disability, hyperkinetic movement, truncal ataxia syndrome (Ataxia, Truncal)\tStructure of glymphatic system (Central Nervous System)\tgallbladder; obstruction (Other diseases of gallbladder)", + "output": "analysis area percentage stroma (Quantitative Concept)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as fibrous ring of heart which consists of the fibrous rings of tricuspid and pulmonary valves.\nConcepts: Epididymis Luminal Protein 113 (Cytoskeletal Proteins)\tSphenobasilar Synchondrosis Extension (Somatic dysfunction of sphenobasilar synchondrosis)\tRight fibrous ring of heart (Fibrous ring of heart)\tFAC016-I Regret My Smoking (Intellectual Product)\tButyryl-CoA dehydrogenase (Flavoproteins)", + "output": "Right fibrous ring of heart (Fibrous ring of heart)" + }, + { + "input": "Definition: something described as a type of magnetic resonance imaging that uses larger, stronger magnets to generate faster scans and higher resolution images.\nConcepts: Quadrivalent HPV [Type 6, 11, 16 and 18] L1 Virus-Like Particle vaccine (Vaccines, Combined)\tquinoline analog (Organic Chemical)\tThyroid Cancer pT3 TNM Finding v6 and v7 (Thyroid Cancer Pathologic Primary Tumor TNM Finding v7)\tNitrous Acid (Nitrogen and nitrogen compound)\tHigh Field Strength Magnetic Resonance Imaging (Diagnostic Procedure)", + "output": "High Field Strength Magnetic Resonance Imaging (Diagnostic Procedure)" + }, + { + "input": "Definition: Respiratory Therapy described as use this term only for respiratory therapy; do not confuse with HYPERPNEA.\nConcepts: day*umol/L/(mg/g/day) (Measurement Unit Description)\tTestosterone Greater than or Equal to 100 Nanograms per Deciliter (Testosterone Level Finding)\thigh-frequency ventilation (Respiratory Therapy)\tPituitary Tumor Surgery (Therapeutic or Preventive Procedure)\tLong Nosed Potoroo (Macropodidae)", + "output": "high-frequency ventilation (Respiratory Therapy)" + }, + { + "input": "Definition: Plant or Plant Part Extract described as black tea is an infusion of dried leaves from plants of the Theaceae family. Due to the alkaloid caffeine, its main effect is stimulation. Black teas also contain other phytochemicals such as flavonoid and flavonoid-related compounds with strong antioxidant effects. They also attenuate atherosclerotic inflammation, reduce thrombosis, promote normal endothelial function, and block expression of cellular adhesion molecules. Black tea may reduce the risk of cancer, heart diseases, infectious diseases, and degenerative diseases.\nConcepts: Management, Data (health science research)\tSynchondrosis (Cartilaginous joint structure)\texpression cloning (Biotechnology)\tBlack Tea (Food)\tAsthma Preparation (Pharmacologic Substance)", + "output": "Black Tea (Food)" + }, + { + "input": "Definition: Disease or Syndrome described as jeavons syndrome is an idiopathic generalised form of reflex epilepsy characterised by childhood onset, unique seizure manifestations, striking light sensitivity, and possible occurrence of generalised tonic-clonic seizures. Onset occurs in childhood, with a peak at 6-8 years of age. Eyelid myoclonia is the principle clinical feature and may or may not be associated with brief (less than 6) absences. The aetiology is unknown but Jeavons syndrome appears to be genetically determined.\nConcepts: Jeavons syndrome (Epilepsy, Reflex)\tMetastatic Urethral Carcinoma (Neoplastic Process)\tPillow, device (Personal effect of patient)\tTobacco Research Implementation Group (Professional Organization or Group)\tProcessedProduct.identifier (Intellectual Product)", + "output": "Jeavons syndrome (Epilepsy, Reflex)" + }, + { + "input": "Definition: Toxicity Tests described as experiments designed to determine the potential toxic effects of mid-term (a few months) exposure to a chemical or chemicals.\nConcepts: Tests, Subchronic Toxicity (Diagnostic Procedure)\tAbnormal incisura morphology (Anatomical Abnormality)\tdisease (or disorder); bowel, vascular (disorder of jejunum and ileum)\tprogesterone,hydrogen-donor:oxygen oxidoreductase (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\tIVD Test Reagent/Kits, Clinical Chemistry, Electrolyte, Ammonia/Ammonium (Medical Device)", + "output": "Tests, Subchronic Toxicity (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as a type of gait ataxia displaying progression of clinical severity.\nConcepts: Progressive gait ataxia (Finding)\tTrophic changes (Finding)\tKaryotyping Pathology Slide Computer-Aided Detection Systems (Medical Device)\tDNA strand elongation involved in DNA replication involved in S-phase (Genetic Function)\tHCCAG (Immunologic Tests)", + "output": "Progressive gait ataxia (Finding)" + }, + { + "input": "Definition: something described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for Lancefield groups E, P, U and V, esculin hydrolysis, pyrrolidonylarylamidase, arginine deamination, CAMP test, beta hemolysis, and growth in 6.5% NaCl and negative for catalase. It can ferment sorbitol, trehalose, maltose, mannitol, ribose, and sucrose but not melibiose, arabinose, inulin, raffinose, or sorbose. S. porcinus is a commensal organism in pigs and pathogenic in humans, causing genitourinary tract infections and complications during parturition.\nConcepts: Grade 2 Intraoperative Venous Injury, CTCAE (Intraoperative Venous Injury, CTCAE)\tWPPSI-IV vocabulary subtest (Intellectual Product)\tPalmar Crease Examination (Intellectual Product)\tStreptococcus porcinus Collins et al. 1985 (Streptococcus)\tC-SSRS Baseline/Screening Version - Description of Active Suicidal Ideation with Specific Plan and Intent (C-SSRS Baseline/Screening Version Questionnaire Question)", + "output": "Streptococcus porcinus Collins et al. 1985 (Streptococcus)" + }, + { + "input": "Definition: Intellectual Product described as patient Health Questionnaire Screener Version (PHQ Screener Version) During the last 4 weeks, how much have you been bothered by pain or problems during sexual intercourse?\nConcepts: 3.1.3 (Intellectual Product)\tPHQ03-Pain/Problems During Intercourse (PHQ Screener Version Questionnaire Question)\tWhooping-cough vaccine (Pharmacologic Substance)\tloss of weight (Physical findings)\tAsarum europaeum / European sanke root (Pharmacologic Substance)", + "output": "PHQ03-Pain/Problems During Intercourse (PHQ Screener Version Questionnaire Question)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of leiomyosarcoma and endometrial stromal sarcoma, following the rules of the TNM AJCC v7 classification system as they pertain to staging of the regional lymph nodes.\nConcepts: geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase activity (Molecular Function)\tantimonium tartaricum/tartra (Homeopathic remedies letter A)\tLeiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)\tanti-HER2 monoclonal antibody CT-P6 (Amino Acid, Peptide, or Protein)\tLARYNGITIS (Laryngeal Diseases)", + "output": "Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Right coronary artery structure described as branch of right coronary artery which runs along the upper third of the posterior interventricular sulcus to supply the posterior wall of right and left ventricles and the posterior third of the interventricular septum.\nConcepts: ATYPICAL CORONARY ARTERY DISEASE SYMPTOMS (Cardiovascular System Signs and Symptoms)\tIDSR1-Concentration/Decision Making (IDS-SR Questionnaire Question)\tPosterior descending coronary artery (Coronary artery part)\tAcanthopodina (Order Amoebida)\tSmilax L., 1753 (Smilacaceae)", + "output": "Posterior descending coronary artery (Coronary artery part)" + }, + { + "input": "Definition: Ventricular septal aneurysm described as bowing (bulging out) of the muscular part of the interventricular septum of more than 10-15 mm into the cavity of an adjacent ventricle (usually into the right ventricle).\nConcepts: PERSONALITY CHANGE (Physical findings)\tcentral retinal vein occlusion (Obstruction of peripheral vein)\tEpithelial tumor, malignant (Primary malignant neoplasm)\tAneurysm of the muscular ventricular septum (Disease or Syndrome)\tMitral valve stenosis (Non-rheumatic heart valve disorder)", + "output": "Aneurysm of the muscular ventricular septum (Disease or Syndrome)" + }, + { + "input": "Definition: Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma described as subcutaneous panniculitis-like T-cell lymphoma that is resistant to treatment.\nConcepts: Foot care (Common nursing interventions)\tRefractory Subcutaneous Panniculitis-Like T-Cell Lymphoma (Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma)\tpositive regulation of gliogenesis (regulation of gliogenesis)\tanterior horn nuclei (Body Part, Organ, or Organ Component)\tRecurrent Vaginal Carcinoma (Vulvovaginal cysts and neoplasms)", + "output": "Refractory Subcutaneous Panniculitis-Like T-Cell Lymphoma (Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: something described as a physician who specializes in neuromuscular medicine possesses specialized knowledge in the science, clinical evaluation and management of these disorders. This encompasses the knowledge of the pathology, diagnosis and treatment of these disorders at a level that is significantly beyond the training and knowledge expected of a general neurologist, child neurologist or physiatrist.\nConcepts: CUP DISC RATIO ELEVATED (Eye)\tDental Pulp Concretion (Experimental Organism Finding)\tAllopathic & Osteopathic Physicians; Physical Medicine & Rehabilitation, Neuromuscular Medicine (Professional or Occupational Group)\tregulation of collagen synthesis (regulation of collagen metabolic process)\tProtein Phosphatase Magnesium-Dependent 1 Delta (Enzyme)", + "output": "Allopathic & Osteopathic Physicians; Physical Medicine & Rehabilitation, Neuromuscular Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Adenocarcinoma in adenomatous polyp described as an adenocarcinoma arising from a tubular adenoma.\nConcepts: Greig Cephalopolysyndactyly Syndrome (Syndrome)\tChildhood Langerhans Cell Histiocytosis without Risk Organ Involvement (Neoplastic Process)\tAdenocarcinoma in Tubular Adenoma (Neoplastic Process)\tDram Mass Unit (Unit of mass)\tSialoglycoprotein (Biologically Active Substance)", + "output": "Adenocarcinoma in Tubular Adenoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as dandelion root.\nConcepts: Joubert syndrome with Jeune asphyxiating thoracic dystrophy (Familial aplasia of the vermis)\tACI/Seg, Rat Strain (Common Rattus Norvegicus Strains)\tLeontodon taraxacum / dandelion root (Plant)\tR-PTP-GAMMA (Gene or Genome)\tBPI Short Form Questionnaire Question (Clinical or Research Assessment Question)", + "output": "Leontodon taraxacum / dandelion root (Plant)" + }, + { + "input": "Definition: Jaw described as the anteriorly located rigid section of the PALATE.\nConcepts: Preschool life and related activities (Educational Activity)\tHard Palate (Body part)\tAnaplastic large cell lymphoma, ALK-positive (Peripheral T-Cell Lymphoma)\tChlorogenic Acid (Organic Chemical)\tFaecalicatena orotica (Clostridium species g-p)", + "output": "Hard Palate (Body part)" + }, + { + "input": "Definition: middle ear described as one of the three bones comprising the middle ear. This anvil-shaped bone is positioned between the malleus and the stapes.\nConcepts: anvil (Incus structure)\tFoot-stab use (Veterinary Route of Administration)\tMKC-1 (Tubulin Binding Agent)\tmechanically-gated channel activity (ion channel activity)\tSudden Death NOS, CTCAE (General Disorders and Administration Site Conditions, CTCAE)", + "output": "anvil (Incus structure)" + }, + { + "input": "Definition: Pharmacotherapy described as drug treatment to prevent, stop, or reduce the severity of seizures or convulsions, commonly used in cases of epilepsy or other seizure disorders.\nConcepts: RING Finger Protein 124 Protein Variant E318D (RNF43 Protein Variant)\tRecently Cleared Concept (Intellectual Product)\tHypophysitis (Endocrine Disorders, CTCAE)\tDental-oral procedure AND/OR service (International Statistical Classification of Diseases and Related Health Problems, 10th Revision, Australian Modification)\tAntiseizure Treatment (Therapeutic or Preventive Procedure)", + "output": "Antiseizure Treatment (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as neuromuscular function analyzers that measure and evaluate the movement of the human body or body segments. Some of these analyzers are automated optoelectronic devices that use pattern recognition and include markers, sensors, image processors, and computers; others use video (normal or high-speed) or cine cameras employing manual digitization or pattern-search algorithms. Analyzers consisting of electromagnetic devices that measure the position and orientation of sensors in space and are capable of measuring three-dimensional movements are also used for motion analysis. Body segment analyzers are used to obtain a graphic image and biomechanical analysis of human body segment movements (e.g., spinal analysis, joint function). These analyzers are used mostly to study the mechanisms of sports, work-related tasks, and rehabilitation activities.\nConcepts: Analyzers, Physiologic, Neuromuscular Function, Body Motion (Medical Device)\tSulfur-Sulfur Bond Isomerases (Amino Acid, Peptide, or Protein)\tImmune Privileges (Organism Function)\t(2S-(2 alpha,5 alpha,6 beta(S*)))-6-(((((3-((2-furanylmethylene)amino)-2-oxo-1-imidazolidinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid (Organic Chemical)\tPHQ01-Feeling Bad About Yourself (Intellectual Product)", + "output": "Analyzers, Physiologic, Neuromuscular Function, Body Motion (Medical Device)" + }, + { + "input": "Definition: something described as a novel very rare form of PCH with clinical manifestations of progressive microcephaly, feeding difficulties and severe developmental delay. Although walking may be achieved, hypotonia often associated with increased muscle tone of lower extremities and deep tendon reflexes, joint deformities in the lower extremities, and occasionally complex seizures are demonstrated. PCH8 is caused by a loss-of-function mutation in the CHMP1A gene.\nConcepts: FAC099-Trouble Finishing Things (Peds-FACIT-F Questionnaire Question)\tCurved proximal toe phalanx (Curved toe phalanx)\tPontocerebellar hypoplasia type 8 (Hereditary disorder of nervous system)\tCOCCIGM (Immunoglobulin M measurement)\tadenosine 3'-phosphate 5'-phosphosulfate metabolic process (purine ribonucleotide metabolic process)", + "output": "Pontocerebellar hypoplasia type 8 (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Container Closure System described as closure whereby a measured quantity of the contents is released by actuation of the valve.\nConcepts: Metering valve (Container Closure System)\tcontractile ring contraction involved in cell cycle cytokinesis involved in mitotic cell cycle (actomyosin contractile ring contraction)\tADP reductase activity (ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)\tsynapse biogenesis involved in innervation (synaptogenesis)\tENTEROCOCCUS RAFFINOSUS (Enterococcus, group I)", + "output": "Metering valve (Container Closure System)" + }, + { + "input": "Definition: something described as human PLXNC1 wild-type allele is located in the vicinity of 12q23.3 and is approximately 159 kb in length. This allele, which encodes plexin-C1 protein, plays a role in semaphorin-dependent signaling leading to cytoskeletal remodeling.\nConcepts: Choking episodes (Pathologic Function)\tCTC (Diagnostic Procedure)\tSF36 v1.0 Standard - Question 4c (SF36 v1.0 Standard Questionnaire Question)\tCD232 (Gene or Genome)\tHomeobox Protein Hox-11L2 (Amino Acid, Peptide, or Protein)", + "output": "CD232 (Gene or Genome)" + }, + { + "input": "Definition: Brain Diseases, Metabolic described as a rare mitochondrial oxidative phosphorylation disorder due to nuclear deoxyribonucleic acid anomalies. The disease is characterized by progressive external ophthalmoplegia without diplopia, cerebellar atrophy, proximal skeletal muscle weakness with generalized muscle wasting, profound emaciation, respiratory failure, spinal deformity and facial muscle weakness (manifesting with ptosis, dysphonia, dysphagia and nasal speech). Intellectual disability, gastrointestinal symptoms (nausea, abdominal fullness, and loss of appetite), dilated cardiomyopathy and renal colic have also been reported.\nConcepts: Palmitic Acylation Site (Amino Acid Sequence)\tIntra-Abdominal Infections (Infection by site)\tC-SSRS Baseline - Most Recent Suicide Attempt Date (Intellectual Product)\tMitochondrial DNA (deoxyribonucleic acid) maintenance syndrome due to MGME1 (mitochondrial genome maintenance exonuclease 1) deficiency (Hereditary disorder of nervous system)\tIncreased size of facial muscles (Abnormality of facial musculature)", + "output": "Mitochondrial DNA (deoxyribonucleic acid) maintenance syndrome due to MGME1 (mitochondrial genome maintenance exonuclease 1) deficiency (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER).\nConcepts: NPI1-Uncooperative (NPI Questionnaire Question)\tinhalation exposure (Environmental Exposure)\tapurinic/apyrimidinic endodeoxyribonuclease activity (Genetic Function)\tCleft lower jaw (CONGENITAL ANOMALIES OF THE TEETH, LIPS AND PALATE)\tregulation of protein adenylation (Molecular Function)", + "output": "apurinic/apyrimidinic endodeoxyribonuclease activity (Genetic Function)" + }, + { + "input": "Definition: something described as trial prostheses that are used to determine the prosthesis size of a permanent replacement for the hip joint.\nConcepts: Callithrix (Callitrichinae)\tHip Trial Implants (Medical Device)\tsilver protein (Proteins)\tObservation of mobility (GENERAL PROBLEMS AND COMPLAINTS)\tPathologic Stage IIC Melanoma of the Skin AJCC v8 (Neoplastic Process)", + "output": "Hip Trial Implants (Medical Device)" + }, + { + "input": "Definition: Anatomy Qualifier described as having to do with the heart and lungs.\nConcepts: Severe to Very Severe Exertion (Intellectual Product)\tFlushing, CTCAE 5 (Finding)\tMonitors, Bedside, Blood Pressure (Monitors, Physiologic)\tSegment (Segment structure)\thearts lungs (Body Location or Region)", + "output": "hearts lungs (Body Location or Region)" + }, + { + "input": "Definition: dendritic transport described as the directed movement of organelles or molecules along microtubules from the cell body toward the postsynapse in dendrites.\nConcepts: Treatment naive (General physical finding)\tFull liquid diet (Liquid diet)\tProcess agent (Concept model attribute)\tanterograde dendritic transport (dendritic transport)\tDecreased serum bile concentration (Finding)", + "output": "anterograde dendritic transport (dendritic transport)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Biologic Response Modifiers Version 4 - Additional Concerns-Mental: I have emotional ups and downs.\nConcepts: Grade 2 Cholecystitis (Cholecystitis, CTCAE 5.0)\tFAC062-I Have Emotional Ups and Downs (FACT-BRM Version 4 Questionnaire Question)\tDermatologic Complication (Complication)\tCompounds, Inorganic Chlorine (Inorganic Chemicals)\tOligochaeta (Class Clitellata)", + "output": "FAC062-I Have Emotional Ups and Downs (FACT-BRM Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Procedure on neck described as removal or sampling of lymph nodes in the supraclavicular area.\nConcepts: SF-36 v2.0 Acute - Question 3d (SF36 v2 0 Acute Questionnaire Question)\tSoftware.buildNumberText (Intellectual Product)\tBlood Urea Nitrogen (Inorganic Chemical)\tbiopsy of supraclavicular lymph node (Procedure on neck)\tribonucleoprotein complex localisation (Cell Function)", + "output": "biopsy of supraclavicular lymph node (Procedure on neck)" + }, + { + "input": "Definition: something described as an auditory brainstem structure in the pontine tegmentum that contains several nuclei associated with auditory localization and is component of ascending and descending auditory pathways.\nConcepts: Orientation, Mental (Mental Processes)\tIntraoperative Complications (other diagnoses and conditions)\tINTLK12B (Laboratory Procedure)\tRegio olivaris superioris (Nuclear complex of neuraxis)\tCommands (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Regio olivaris superioris (Nuclear complex of neuraxis)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: beta-amyrin + O2 + H+ + NAD(P)H <=> 12,13beta-epoxy-beta-amyrin + H2O + NAD(P).\nConcepts: Investigational Product Return Record (Records)\tcytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity (Molecular Function)\talpha-beta T cell proliferation involved in immune response (T cell proliferation involved in immune response)\tOccipital Lobe, Parietal Lobe, and Ventricular Ependymal Tumor (Ependymoma of brain)\tHydnocarpi / da feng zi (Oriental herbs and natural substances letter H)", + "output": "cytochrome P450 dependent beta-amyrin 12,13beta-epoxidase activity (Molecular Function)" + }, + { + "input": "Definition: Pharmaceutical Preparations described as drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms.\nConcepts: host cell pre-synaptic membrane (Cell Component)\tCognitive Enhancer (Pharmacologic Substance)\tdownregulation of cell chemotaxis to fibroblast growth factor (regulation of cell chemotaxis to fibroblast growth factor)\tGallbladder Cancer TNM Finding v8 (Hepatobiliary System Cancer TNM Finding v8)\tAssessedResultRelationship (Qualitative Concept)", + "output": "Cognitive Enhancer (Pharmacologic Substance)" + }, + { + "input": "Definition: Specific mental functions described as those affective states which can be experienced and have arousing and motivational properties.\nConcepts: Emotional (Specific mental functions)\tNeutrophil Count Decreased (Finding)\tCramp (Peripheral tissue perfusion status)\t354-355 PARVOVIRUS GROUP (Virus)\t2,4-dichlorobenzoate catabolism (aromatic compound catabolic process)", + "output": "Emotional (Specific mental functions)" + }, + { + "input": "Definition: Respiratory auscultation finding described as crackles are discontinuous, explosive, and nonmusical adventitious lung sounds normally heard in inspiration and sometimes during expiration. Crackles are usually classified as fine and coarse crackles based on their duration, loudness, pitch, timing in the respiratory cycle, and relationship to coughing and changing body position.\nConcepts: Pulmonary Rales (Finding)\tCSS0308B (Intellectual Product)\tregulation of tonic skeletal muscle contraction (Organism Function)\tSWS (Gene or Genome)\tCLARP2 (CFLAR Gene Product)", + "output": "Pulmonary Rales (Finding)" + }, + { + "input": "Definition: Colchicine-Site Binding Agent described as a pentafluorophenylsulfonamide compound with potential antineoplastic activity. T900607 inhibits tubulin polymerization by binding irreversibly to colchicine binding sites, resulting in cell cycle arrest and apoptosis.\nConcepts: Long Murmur (Heart murmur, categorized by duration)\tT-900607 (Organic Chemical)\tcalorie IT (Quantitative Concept)\tdown regulation of protein uptake (regulation of protein import)\tType 11 Voltage-Gated Sodium Channel (Biologically Active Substance)", + "output": "T-900607 (Organic Chemical)" + }, + { + "input": "Definition: Gastrointestinal Carcinoid Tumor described as a well differentiated, low grade neuroendocrine tumor (carcinoid tumor) arising from the gastrointestinal tract. It is characterized by the presence of enterochromaffin-like type granules in the neoplastic cells.\nConcepts: cerebellum morphogenesis (Morphogenesis)\tPrint, Sign, Date Form (Form Directive)\tTone of muscles of trunk (Muscle tone functions)\totomy (Surgical incisions)\tECL Cell NET G1 (Neoplastic Process)", + "output": "ECL Cell NET G1 (Neoplastic Process)" + }, + { + "input": "Definition: epithalamus related medial forebrain bundle system described as a structure in the rat that emerges caudally from between the habenular commissure and the posterior commissure to connect with the pineal gland ( Swanson-2004 ).\nConcepts: PQL03-Hard Explain Illness to People (Intellectual Product)\tNEOPL MALIGNANT EPITHELIAL (Primary malignant neoplasm)\tCC-MELD TEST (CDISC Clinical Classification Terminology)\tpineal stalk (Body Part, Organ, or Organ Component)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Antiphospholipid Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune)", + "output": "pineal stalk (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Laboratory Procedure described as the act of immobilizing one or more detection agents to a solid-phase support for an in vitro diagnostic device.\nConcepts: hormone synthesis (Anabolism)\tembryo/fetus drug adverse effect (Injury or Poisoning)\tFiber splitting (Abnormal muscle fiber morphology)\tCoating, Solid Phase Antigen/Antibody/Nucleic Acid for in Vitro Diagnostic Device (Laboratory Procedure)\tRisk Control: Tobacco Use (Individual Behavior)", + "output": "Coating, Solid Phase Antigen/Antibody/Nucleic Acid for in Vitro Diagnostic Device (Laboratory Procedure)" + }, + { + "input": "Definition: Therapeutic procedure described as the use of RADIO WAVES to conduct therapeutic procedures. The specific frequency, dosage, and intensity used vary depending on the desired effects which include heating, electrical stimulation, or ablation of tissues.\nConcepts: Blood (in);stool (Gastrointestinal System Finding)\tMDM2 antagonist RO5045337 (Pharmacologic Substance)\tRadiofrequency Therapy (Therapeutic or Preventive Procedure)\tSoft Tissue Sarcoma pN1 TNM Finding v7 (Soft Tissue Sarcoma Pathologic Regional Lymph Nodes TNM Finding v7)\tmicromeria douglasii/yerba b (Homeopathic remedies letter M)", + "output": "Radiofrequency Therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a unit of amount of substance content measured as the number of moles of a solute substance (component) per mass of the solvent.\nConcepts: Dideoxyadenosine (Deoxyadenosines)\tMolality (Quantitative Concept)\tSensation related to the skin (Organ or Tissue Function)\tCloaca Chamber (Other Embryologic Structure)\trelaxation (Activity)", + "output": "Molality (Quantitative Concept)" + }, + { + "input": "Definition: something described as a myeloarchitectural term denoting a horizontal plexus of myelinated fibers in the molecular layer of the cerebral cortex ( Schiebler-1999 ).\nConcepts: DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter (DNA-directed RNA polymerase activity)\tGDS01-Feel Hopeless (GDS Questionnaire Question)\tOPCA Gene Mutation (Gene Mutant)\tAbnormality of the end part of the innermost long bone in upper arm (Anatomical Abnormality)\tplexus of Exner (Body Part, Organ, or Organ Component)", + "output": "plexus of Exner (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of action potential creation, propagation or termination. This typically occurs via modulation of the activity or expression of voltage-gated ion channels.\nConcepts: ATPase-coupled ferric-hydroxamate transmembrane transporter activity (Molecular Function)\tupregulation of action potential (Cell Function)\tp68 (Gene or Genome)\ttumor warthin's (Benign Epithelioma)\tFecal Incontinence or Requires Enema (Finding)", + "output": "upregulation of action potential (Cell Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: [myelin proteolipid] + palmityl-CoA = [myelin proteolipid] O-palmitoylprotein + CoA.\nConcepts: myelin PLP acyltransferase activity (Molecular Function)\tD-Isoglucosamine (Simple organic compound)\trecruitment (Functional Concept)\tparasomnia (Parasomnia)\tSIOP/COG/NWTSG Stage I (SIOP/COG/NWTSG Staging System)", + "output": "myelin PLP acyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a laboratory test result indicating normal bone marrow cells.\nConcepts: Symptom Indicator (Indicator)\tTherapeutic venesection (Other incision procedures on veins)\tphylloquinone epoxide reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor)\tNormal Bone Marrow Test Result (Normal Laboratory Test Result)\tmacrophage fusion (syncytium formation by plasma membrane fusion)", + "output": "Normal Bone Marrow Test Result (Normal Laboratory Test Result)" + }, + { + "input": "Definition: In Vitro Diagnostics and Laboratory Equipment described as a sorbent hemoperfusion system is a device that consists of an extracorporeal blood system similar to that identified in the hemodialysis system and accessories (Sec. 876.5820) and a container filled with adsorbent material that removes a wide range of substances, both toxic and normal, from blood flowing through it. The adsorbent materials are usually activated-carbon or resins which may be coated or immobilized to prevent fine particles entering the patient's blood. The generic type of device may include lines and filters specifically designed to connect the device to the extracorporeal blood system. The device is used in the treatment of poisoning, drug overdose, hepatic coma, or metabolic disturbances.\nConcepts: regulation of selenocysteine insertion sequence binding (regulation of mRNA binding)\tInterleukin-4 (Lymphokines)\tMeasured intake of infant formula in 24 hours (Quantitative Concept)\tRabies virus (Virus)\tApheresis Immunoadsorption Columns (Medical Device)", + "output": "Apheresis Immunoadsorption Columns (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as michigan Neuropathy Screening Instrument (MNSI) Physical assessment; appearance of right foot - fissure.\nConcepts: S100Z protein, human (Biologically Active Substance)\t64Cu-DOTA-U3-1287 (Radioimmunoconjugates)\tGUSB (Amino Acid, Peptide, or Protein)\tAlimentary obesity (Finding)\tMNSI121 (MNSI Questionnaire Question)", + "output": "MNSI121 (MNSI Questionnaire Question)" + }, + { + "input": "Definition: Manufactured Object described as power systems designed for use as a source of electric and/or mechanical power to instruments and/or other powered devices used in neurosurgery and small bone surgery. These systems usually consist of a main unit that provides electric and/or mechanical power using a motor to detachable handpieces appropriate to drive dedicated instruments (e.g., saws, burs, blades, drills, debriders, liposuction); a power switch (e.g., a foot-control unit), a line cord, and a panel for handpiece/instrument connection. Most systems have pumps used for irrigation and/or cooling; some also can provide pneumatic and/or ultrasonic power. Orthopedic and plastic surgery power systems are used in a variety of neurosurgery and small bone (e.g., spine) surgical procedures.\nConcepts: Coloring, Prosthesis (Therapeutic or Preventive Procedure)\tHOLOGR (Imaging, Three-Dimensional)\tPlannedCriterionGroupOptionRelationship.priorityNumber (Intellectual Product)\tPower Systems, Neurosurgery/Small Bones (Power Systems, Electromechanical, Surgery)\tAmmonium phosphoricum / ammonium phosphate (Pharmacologic Substance)", + "output": "Power Systems, Neurosurgery/Small Bones (Power Systems, Electromechanical, Surgery)" + }, + { + "input": "Definition: something described as a neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage. Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias. Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas.\nConcepts: HLA-B Match Status (Finding)\tNeutrophil Gelatinase Associated Lipocalin (Amino Acid, Peptide, or Protein)\tPrecursor Lymphoid Neoplasm (Neoplastic Process)\tMEDI-0457 (Immunologic Factor)\tCDISC Questionnaire MNSI Test Name Terminology (Intellectual Product)", + "output": "Precursor Lymphoid Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: intramolecular lyase activity described as catalysis of the reaction: alpha-pinene = limonene.\nConcepts: NES gene (Gene or Genome)\tjoint mobilizations (Anatomical transformation entity)\talpha-pinene lyase activity (Molecular Function)\tAcidic Region (Protein Domain)\tTraction Method (Cranial osteopathic manipulation)", + "output": "alpha-pinene lyase activity (Molecular Function)" + }, + { + "input": "Definition: growth factor receptor binding described as interacting selectively and non-covalently with the interleukin-3 receptor.\nConcepts: interleukin-3 receptor binding (Molecular Function)\tPD Fluid (Dialysis Solutions)\tManaging changes in daily routine (Daily or Recreational Activity)\tFACT-HEP Version 4 - Get Emotional Support From Family (Intellectual Product)\tCancer of the Gastrointestinal Tract (Neoplastic Process)", + "output": "interleukin-3 receptor binding (Molecular Function)" + }, + { + "input": "Definition: modulation of process of other organism involved in symbiotic interaction described as a process in which an organism has a negative effect on the functioning of the second organism's cells, where the two organisms are in a symbiotic interaction.\nConcepts: DDS01 (Intellectual Product)\tGlycine Dehydrogenase (Amino Acid, Peptide, or Protein)\tdisruption of cells of other organism involved in symbiotic interaction (Organism Function)\tCSS0501B (Intellectual Product)\tOSLAM syndrome (Multiple malformation syndrome with limb defect as major feature)", + "output": "disruption of cells of other organism involved in symbiotic interaction (Organism Function)" + }, + { + "input": "Definition: Biologically Active Substance described as zinc finger E-box-binding homeobox 2 (1214 aa, ~136 kDa) is encoded by the human ZEB2 gene. This protein is involved in the negative regulation of transcription.\nConcepts: Inner/Lumen Diameter (Quantitative Concept)\tSMADIP1 (Biologically Active Substance)\tPediatric Myxoid Chondrosarcoma (Neoplastic Process)\tAtraumatic Restorative Treatment, Dental (Therapeutic or Preventive Procedure)\tlipancreatin (Digestants)", + "output": "SMADIP1 (Biologically Active Substance)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as facilitating rehabilitative exercise for a client to obtain, restore and/or improve his or her muscle strength. Service is billed in 15-minute increments.\nConcepts: divalent inorganic cation homeostasis (cation homeostasis)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, VWF (Medical Device)\tCCCWFU (Health Care Related Organization)\tDevice Observer Model Name (Name)\texercise strengthening (Muscle strength exercise)", + "output": "exercise strengthening (Muscle strength exercise)" + }, + { + "input": "Definition: Scleroproteins described as globular subunit of microtubules, whose ATP- and GTP-dependent polymerization and depolymerization is the basis for many intracellular movement functions.\nConcepts: CellSave Preservative Tube (Medical Device)\tSDTM-CVTESTCD (CDISC SDTM Terminology)\tTubulin (Proteins)\tGrade 2 Tooth development disorder (Tooth Development Disorder, CTCAE)\tBlood DNA (Biospecimen)", + "output": "Tubulin (Proteins)" + }, + { + "input": "Definition: Incorrect, Inadequate or Imprecise Result or Readings described as problem associated with the device incorrectly reporting that something has been detected and may mislead the operator to take certain actions.\nConcepts: down regulation of endothelial cell proliferation (regulation of endothelial cell proliferation)\tFalse Positive Result (Incorrect, Inadequate or Imprecise Result or Readings)\tParotid Lymphangioma (Neoplastic Process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, BBS10 (Medical Device)\tmarsupials (Theria )", + "output": "False Positive Result (Incorrect, Inadequate or Imprecise Result or Readings)" + }, + { + "input": "Definition: something described as a species of aerobic, Gram negative bacteria assigned to the phylum Bacteroidetes. This species is nonsaccharolytic, oxidase and catalase positive and can produce indole. W. virosa is found in the genitourinary tract and is pathogenic causing peritonitis and vaginitis.\nConcepts: error-free translesion synthesis (translesion synthesis)\tWeeksella virosa Holmes et al. 1987 emend. Hahnke et al. 2016 (Bacterium)\tLevel 4 Major External Structural Defect (GAIA Major Congenital Anomalies Level of Diagnostic Certainty)\tneoplasm of pleura (oncologic disorders)\tNITROXINIL (Pharmacologic Substance)", + "output": "Weeksella virosa Holmes et al. 1987 emend. Hahnke et al. 2016 (Bacterium)" + }, + { + "input": "Definition: formation of extrachromosomal circular DNA described as a telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).\nConcepts: hepsulfam (Alkylsulfonate Compound)\tt-circle formation (Genetic Function)\tair treatment (Occupational Activity)\tRockport One Mile Walk Test Version 1.0 Functional Test (Intellectual Product)\tantibody Toxoplasma gondii IgM (Immunologic Tests)", + "output": "t-circle formation (Genetic Function)" + }, + { + "input": "Definition: something described as quality Of Life Enjoyment And Satisfaction Questionnaire - With regard to your physical health, during the past week how much of the time have you: Felt good physically?\nConcepts: central canal development (Organ or Tissue Function)\tSpinoreticular fibers set (Spinothalamic Tracts)\tQLES1-Felt Good Physically (Intellectual Product)\tOxandrolone product (Androstanols)\thistone lysine N-methyltransferase activity (Molecular Function)", + "output": "QLES1-Felt Good Physically (Intellectual Product)" + }, + { + "input": "Definition: Behavior Modification & Therapy described as training in the social skills required to be able to refuse requests; to express both positive and negative feelings; to initiate, engage in, and terminate conversation; and to make personal requests without suffering from excessive stress.\nConcepts: 11q22.3 (Chromosome band)\tAbnormal left atrium morphology (Abnormal cardiac atrium morphology)\tAssertiveness training (Life skills training)\tPODCI364 (PODCI Adolescent Self-Reported Version Questionnaire Question)\tToxin, Clostridium tetani (Bacterial Toxins)", + "output": "Assertiveness training (Life skills training)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic mixed opioid agonist-antagonist with analgesic properties. Although its exact mechanism has not been fully delineated, it is hypothesized that upon administration, nalbuphine binds to kappa receptors in the central nervous system (CNS), thereby inhibiting the release of neurotransmitters that mediate pain, such as substance P. Additionally, nalbuphine exerts post-synaptic inhibitory effects on interneurons and output neurons of the spinothalamic tract, responsible for transporting nociceptive information. Compared to other opioid agents that stimulate mu receptors, nalbuphine antagonizes mu receptors, thereby potentially producing less intense respiratory depression.\nConcepts: Nalbuphin (Morphinan derivatives, opiod analgesics)\tMaximum Value Derivation Technique (Quantitative Concept)\tBabesia Starcovici, 1893 (Family Babesiidae)\tSkene Gland (Urethra)\tchildbirth (LABOR AND PARTURITION)", + "output": "Nalbuphin (Morphinan derivatives, opiod analgesics)" + }, + { + "input": "Definition: something described as a scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.\nConcepts: Reticular Fibril (Proteins)\tNursing & Custodial Care Facilities; Hospice, Inpatient (Health Care Related Organization)\tAAML03P1 (Intellectual Product)\tCliones (Gastropoda)\tCHSF1-Unpaid Personal Care per Day (Intellectual Product)", + "output": "Reticular Fibril (Proteins)" + }, + { + "input": "Definition: Posterior pituitary disease described as a form of diabetes insipidus related to a failure of vasopressin (AVP) release from the hypothalamus.\nConcepts: DHA reductase activity (glutathione disulfide oxidoreductase activity)\tDiabetes insipidus secondary to vasopressin deficiency (Hypopituitarism)\tsemaphorin receptor binding (signaling receptor binding)\tInsertion procedure (Introduction procedure)\tNone (Finding)", + "output": "Diabetes insipidus secondary to vasopressin deficiency (Hypopituitarism)" + }, + { + "input": "Definition: Organic Chemical described as 2-Octylcyclopentaneheptanoic acids. The family of saturated carbon-20 cyclic fatty acids that represent the parent compounds of the prostaglandins.\nConcepts: negative regulation of TLR9 signaling pathway (Physiologic Function)\tprotein K27-linked deubiquitination (Deubiquitination)\tRAD51L2 Gene Mutation (Cell or Molecular Dysfunction)\tregulation of mitotic DNA damage checkpoint (Cell Cycle Control)\tProstanoic Acids (Organic Chemical)", + "output": "Prostanoic Acids (Organic Chemical)" + }, + { + "input": "Definition: Software, Workstation Management described as software designed to operate picture archiving and communication systems (PACS) workstations, control/monitor a limited number of their functions, and/or process data and images obtained during scanning imaging procedures. This software usually interacts with devices used in the procedure, such as diagnostic imaging systems (e.g., computed tomography, magnetic resonance imaging, and ultrasound scanning systems) as well as with recorders with high image archiving capabilities. The software also performs a variety of algorithms to facilitate the operation and analysis of the images obtained during the procedures. PACS workstation management software is intended to work only with one or a few models of workstations and related devices, usually supplied by the same manufacturer. This facilitates the processing and/or sending of data from the workstation to and from other hospital information systems. PACS software is not usually available separate from the workstation but may be updated (i.e., through the release of modified versions) during the life of the equipment. Dedicated software intended for three-dimensional processing and analysis of the images is also available.\nConcepts: Isosorbide (sorbitol)\tcarnitine degradation (carnitine metabolic process)\tStage II Gastric Neuroendocrine Tumor AJCC v8 (Neoplastic Process)\tPicture Archiving and Communication System Workstation Management Software (Intellectual Product)\tPregnancy Complications, Parasitic (Disease or Syndrome)", + "output": "Picture Archiving and Communication System Workstation Management Software (Intellectual Product)" + }, + { + "input": "Definition: malvids described as an order of mostly woody plants in the superorder ROSANAE. Members of the MALVALES grow in various habitats around the world.\nConcepts: BTHLM1 (Myopathy)\tLubrications (Physics)\tEmergency Stop Button Device (Manufactured Object)\tNegative Regulation of Myeloid Cell Apoptotic Process (Myeloid Cell Apoptotic Process)\tMalvales (Rosanae)", + "output": "Malvales (Rosanae)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a non-specified hospital service or procedure code. Use associated HCPCS II codes to bill for hospital service(s). This code is used for scope-of-practice mapping, not for billing.\nConcepts: PCM1-RET Fusion Gene (Fusion Gene)\tComprehensive Oculocutaneous Disorder Gene Panel Reagents (Medical Device)\tNnspcfd HCPCS hospital ref (Tracking code use with or without ICD diagnosis)\tStage IV Ovarian Dysgerminoma AJCC v7 (Stage IV Ovarian Germ Cell Tumor AJCC v6 and v7)\tupregulation of retinal ganglion cell axon guidance (positive regulation of axon guidance)", + "output": "Nnspcfd HCPCS hospital ref (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: Micrococcus described as genus of gram positive, spherical bacteria found in soils and fresh water, and frequently on the skin of man and other animals.\nConcepts: Micrococcus (Bacterium)\tFIGO Stage IV (FIGO Stage)\t(Quantitative Concept)\tParoxetine hydrochloride (Serotonin Uptake Inhibitors)\tCSS0913 (C-SSRS Screening Questionnaire Question)", + "output": "Micrococcus (Bacterium)" + }, + { + "input": "Definition: diagnostic procedure described as a non-invasive method for diagnosing peripheral nervous system disorders. It determines an individual's sensation and pain thresholds for cold and warm temperatures, and vibration sensation threshold by stimulating the skin and comparing the results to standard values.\nConcepts: Quantitative Sensory Testing (Peripheral neurophysiological procedures)\tHAMD406 (Intellectual Product)\tAssimilatory NADPH Nitrate Reductase (Flavoproteins)\tBorderline Ovarian Mucinous Tumor, Endocervical-Like (Neoplastic Process)\tline (Unit of length)", + "output": "Quantitative Sensory Testing (Peripheral neurophysiological procedures)" + }, + { + "input": "Definition: something described as a subjective score of 10 on a fatigue scale that ranges from 0: Does Not Interfere to 10: Completely Interferes.\nConcepts: CCNA2 (Biologically Active Substance)\tFatigue Interference Score 10 (Clinical or Research Assessment Answer)\tUVA Light Therapy (Therapeutic or Preventive Procedure)\tNucleotide Sequencing Flow Cell (Diagnostic, Therapeutic, and Research Equipment)\tAATF wt Allele (AATF gene)", + "output": "Fatigue Interference Score 10 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a systemic therapy which ensures that a specific prodrug is not converted into the active moiety anywhere but at the sites where the enzyme-linked, tumor-specific antibodies have localized.\nConcepts: ADEPT (Therapeutic or Preventive Procedure)\tinterleukin-17 secretion (cytokine secretion)\tGallbladder Goblet Cell Carcinoid (Gallbladder Mixed Adenoneuroendocrine Carcinoma)\tConcomitant Medication Reason Not Collected (Not-Done Reason)\tmelanophore differentiation (Cell Function)", + "output": "ADEPT (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a fully human monoclonal antibody against RON (recepteur d'origine nantais; macrophage stimulating 1 receptor), with potential antineoplastic activity. Anti-RON monoclonal antibody IMC-RON8 binds to RON, thereby preventing binding of its ligand hepatocyte growth factor-like protein (HGFL or macrophage-stimulating protein (MSP)). This may prevent RON receptor-mediated signaling and may prevent cellular proliferation in tumor cells overexpressing RON. RON, a receptor tyrosine kinase, is overexpressed in a variety of epithelial cancer cell types and plays an important role in cellular proliferation, migration and invasion.\nConcepts: Lansoprazole (Proton Pump Inhibitor [EPC])\tDRRI-2 - A: Serious Financial Problems (DRRI-2 Questionnaire Question)\tphotoreceptor ribbon synapse (Body Space or Junction)\tNarnatumab (Amino Acid, Peptide, or Protein)\tVaginal synovitis (Hand)", + "output": "Narnatumab (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Urine protein test described as the determination of the ratio of delta aminolevulinate compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: DALACRT (Laboratory Procedure)\tIncreased concentration of sialylated N-glycans on glycoproteins (Finding)\tRHODOCOCCUS (Gram-Positive Rods)\tStructure of atrioventricular septum (Heart)\tHAMD-17 - Total Score (Intellectual Product)", + "output": "DALACRT (Laboratory Procedure)" + }, + { + "input": "Definition: H/O: heart failure described as heart failure which leads an individual to seek medical attention.\nConcepts: Parent-infant attachment behavior (Parenting behavior)\tMeasurable (Functional Concept)\tHeart Failure Prompting Medical Attention Event (H/O: heart failure)\t2p11 (Chromosome band)\tmagnetoreception by sensory perception of electrical stimulus (sensory perception of electrical stimulus)", + "output": "Heart Failure Prompting Medical Attention Event (H/O: heart failure)" + }, + { + "input": "Definition: something described as human CBFB wild-type allele is located in the vicinity of 16q22.1 and is approximately 72 kb in length. This allele, which encodes core-binding factor subunit beta protein, plays a role in the mediation of transcription. Acute myeloid leukemia of the M4Eo subtype is linked to the occurrence of a chromosomal inversion inv(16)(p13;q22), which fuses this gene to the MYH11 gene.\nConcepts: Human Peripheral And Cord Blood Cell Product (Pharmacologic Substance)\tDocument Version Relationship Type Code (Intellectual Product)\tCore-Binding Factor, Beta Subunit Gene (CBFB gene)\tDTR Gene (HBEGF gene)\tFAC030-I Am Able to Enjoy Life (Intellectual Product)", + "output": "Core-Binding Factor, Beta Subunit Gene (CBFB gene)" + }, + { + "input": "Definition: Aldehydes and derivatives described as a hypnotic and sedative with anticonvulsant effects. However, because of the hazards associated with its administration, its tendency to react with plastic, and the risks associated with its deterioration, it has largely been superseded by other agents. It is still occasionally used to control status epilepticus resistant to conventional treatment.\nConcepts: PARALDEHYDE (Pharmaceutical Preparations)\tCarcinoma 256, Walker (Experimental Model of Disease)\tCervical dermoid cyst (Neoplastic Process)\tNickel Protoxide (Inorganic Chemical)\tPartial Inversion of Epiglottis During Swallowing (Impairment of Epiglottic Movement)", + "output": "PARALDEHYDE (Pharmaceutical Preparations)" + }, + { + "input": "Definition: something described as administration of a veterinary medicinal product by placing it or sprinkling over a bee hive.\nConcepts: Heparan Sulfate Glycosaminoglycan Mimetic M402 (Organic Chemical)\tIn-Bee-Hive (Drug Administration Routes)\tElectrically Controlled ER Patch (Extended Release Patch Dosage Form)\tpercutaneous transhepatic biliary drainage (Therapeutic procedure)\tCarcinoma of Penis (Primary malignant neoplasm of penis)", + "output": "In-Bee-Hive (Drug Administration Routes)" + }, + { + "input": "Definition: something described as physical location of FZD4_Gene\nConcepts: Vision check NOS (Diagnostic Procedure)\tDSCAT (Categories)\tPRK - Photorefractive keratectomy (eyes and vision)\tCDISC Protocol Study Oversight Entity Attribute Terminology (CDISC Protocol Terminology)\t11: 86344081-86334370 (Chromosome 11 Physical Location)", + "output": "11: 86344081-86334370 (Chromosome 11 Physical Location)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid preparation intended to be diluted in the specified liquid to obtain a nebuliser solution.\nConcepts: Gram per Cage (Unit of Dose Calculation)\tConcentrate for Nebulizer Solution Dosage Form (Biomedical or Dental Material)\tPrimary sideroblastic anaemia, NOS (Anemia)\tCDGSH iron sulfur domain 1 protein, human (Biologically Active Substance)\tFAC018-Difficulty Planning for Future (FACT-LYM Version 4 Questionnaire Question)", + "output": "Concentrate for Nebulizer Solution Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as tomato juice derived from the tangerine tomato, with potential antioxidant and chemopreventive activities. Tangerine tomato juice contains higher levels of the cis-isomer of lycopene (cis-LYC) compared to the trans-isomer (trans-LYC). Lycopene, a linear, unsaturated hydrocarbon carotenoid, is the major red pigment in certain fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava. As an antioxidant, lycopene scavenges free radicals, which may both inhibit cellular oxidation and prevent free radical damage to cells. cis-LYC is better absorbed than its trans form. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C116327\" active clinical trials using this agent.\nConcepts: Tangerine Tomato Juice (Juice)\tDIVERSITY GENET (Gene Frequency)\tWire Crimpers (Medical Device)\tSubstance with chelating agent mechanism of action (medications and vaccines)\tInguinal freckling (Skin, Human)", + "output": "Tangerine Tomato Juice (Juice)" + }, + { + "input": "Definition: something described as a condition following an arterial switch operation to correct transposition of the great arteries, in which the old aortic root becomes the new pulmonary root and where outflow of blood from the right ventricle of the heart is obstructed at the level of the pulmonic valve.\nConcepts: How you compare to others whose health does not limit them (Intellectual Product)\tSmall Intestine Cancer pNX TNM Finding v7 (Finding)\tNeopulmonary valve stenosis (Disease or Syndrome)\tAsian Indian (South Asian)\tlysidinum/ethylene-ethenyl-d (Pharmacologic Substance)", + "output": "Neopulmonary valve stenosis (Disease or Syndrome)" + }, + { + "input": "Definition: Monitors, Environmental described as environmental monitors designed to continuously detect, measure, and display relative humidity (RH) or RH and temperature. These monitors may also store a limited number of readings, for example, maximum and minimum readings. These units can be wall mounted or freestanding. Air humidity/temperature environmental monitors can be used to monitor air conditions in environmental chambers, chemical storage areas, cleanrooms, incubators, and stockrooms.\nConcepts: Monitors, Environmental, Air Humidity/Temperature (Monitors, Environmental)\t4-aminobutyric acid (Neurotransmitters)\ttoxin export channel activity (toxin transmembrane transporter activity)\tGrade 4 Pharyngeal anastomotic leak (Pharyngeal Anastomotic Leak, CTCAE)\tProtein Biosynthesis (Protein Metabolism Process)", + "output": "Monitors, Environmental, Air Humidity/Temperature (Monitors, Environmental)" + }, + { + "input": "Definition: something described as a severity result of two, on a five level scale.\nConcepts: Immunoglobulin G1, Anti-(Human Interleukin 23) (Human-Mus Musculus Monoclonal Heavy Chain), Disulfide with Human-Mus Musculus Monoclonal Light Chain, Dimer (Amino Acid, Peptide, or Protein)\tPosterior Choroidal Artery (Posterior choroidal artery and its branches)\tstage III extrahepatic bile duct cancer (Neoplastic Process)\tSeverity Two Out of Five (Finding)\teatng disrdr mgmt ndvdlea.15 (Nutritional Support)", + "output": "Severity Two Out of Five (Finding)" + }, + { + "input": "Definition: RNA 3' End Processing described as any process involved in forming the mature 3' end of a non-coding RNA molecule.\nConcepts: Host-Tumor Interaction (Pathologic Function)\tPlace Actual Indicator (Functional Concept)\tncRNA 3'-end processing (ncRNA processing)\tretinogenesis (Organ or Tissue Function)\tnegative regulation of septum digestion after cytokinesis (negative regulation of cell division)", + "output": "ncRNA 3'-end processing (ncRNA processing)" + }, + { + "input": "Definition: Amino Acid Sequence described as a sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown to be present, in a conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length.\nConcepts: Ann Arbor Stage II Centroblastic Lymphoma (Stage II Diffuse Large B-Cell Lymphoma)\tEGF-Like Domain (Amino Acid Sequence)\tCandela (Base Unit of International System of Units)\t(MM)-oxidase activity (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor)\tHemophilus paraphrohemolyticus (Hemophilus)", + "output": "EGF-Like Domain (Amino Acid Sequence)" + }, + { + "input": "Definition: something described as stage IVB includes: Any T, Any N, M1. M1: Distant metastasis.\nConcepts: Exocrine Pancreatic Cancer pT4 TNM Finding v8 (Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v8)\tSHIELD, EYE, OPHTHALMIC (Medical Device)\tRefractory Oral Cavity Squamous Cell Cancer (Refractory Head and Neck Squamous Cell Carcinoma)\tStage IVB Hepatocellular Cancer (Neoplastic Process)\tCDISC SDTM NHLBI Coronary Artery Dissection Grade Responses Terminology (CDISC SDTM Terminology)", + "output": "Stage IVB Hepatocellular Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Seizures, Focal described as epilepsia partialis continua (also called Kojevnikov's or Kozhevnikov's epilepsia) is a type of focal motor status epilepticus characterized by repeated stereotyped simple motor manifestations such as jerks, typically of a limb or the face, recurring every few seconds or minutes for extended periods (days or years).\nConcepts: Bile Duct Squamous Cell Carcinoma (Neoplastic Process)\tFACT-P Version 4 - Content With Quality of My Life (Intellectual Product)\tEpilepsia Partialis Continua (Status Epilepticus)\tADH4 gene (Oxidoreductase Gene)\tMEDI 7247 (Antineoplastic Antibody-Drug Conjugate)", + "output": "Epilepsia Partialis Continua (Status Epilepticus)" + }, + { + "input": "Definition: something described as a CXC chemokine that is chemotactic for B-LYMPHOCYTES. It has specificity for CXCR5 RECEPTORS.\nConcepts: DC - Descending colon (Body Part, Organ, or Organ Component)\tdolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity (glucosyltransferase activity)\tteleradiology (Technology, Radiologic)\tlifelong otolith mineralization (otolith mineralization)\tCXCL13, Chemokine (CXC Chemokines)", + "output": "CXCL13, Chemokine (CXC Chemokines)" + }, + { + "input": "Definition: Bronchopulmonary Dysplasia, Adverse Event described as supplemental oxygen at 28 days AND need for >30% oxygen or positive pressure at 36 weeks PMA in infants born <32 weeks' gestation; need for >30% oxygen or positive pressure by 56 days postnatal age in infants born >32 weeks' gestation; need for >30% oxygen and/or positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to FiO2: see http://nicutools.org/MediCalcs/ActualO2.php3.\nConcepts: Grade 3 BPD, AE (Bronchopulmonary Dysplasia, Adverse Event)\tPharyngeal Carcinoma by AJCC v6 Stage (Pharyngeal Carcinoma)\tIDS-SR - Score (Intellectual Product)\tIntravenous use (RouteBySite)\tCSAG Family, Member 3 Gene (Gene or Genome)", + "output": "Grade 3 BPD, AE (Bronchopulmonary Dysplasia, Adverse Event)" + }, + { + "input": "Definition: Functional Concept described as preparing, initiating and arranging the time and space required for a simple task; executing a simple task with a single major component, such as building a tower, putting on a shoe, reading a book, writing a letter, or making one's bed.\nConcepts: Undertaking a simple task (Undertaking a single task)\tGrade 1 Duodenal Stenosis, CTCAE (Finding)\tAtherosclerotic Cardiovascular Disease (Diseases of arteries, arterioles and capillaries)\tFPV-Brachyury-TRICOM Vaccine (Pharmacologic Substance)\t4-Hydroxypyrazolopyrimidine (Allopurinol and purine inhibitors)", + "output": "Undertaking a simple task (Undertaking a single task)" + }, + { + "input": "Definition: Naturally occurring alkaloid described as vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).\nConcepts: DRRI-2 - C: Wasn't Able to Contact Home (DRRI-2 Questionnaire Question)\tTyrphostin AG 1296 (Organic Chemical)\tVincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)- (Vinca-Domain Binding Agent)\tPerfluorocarbons (Organic Chemical)\tRETINITIS PIGMENTOSA 21, FORMERLY (Hereditary Diseases)", + "output": "Vincaleukoblastine, 3-(aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)- (Vinca-Domain Binding Agent)" + }, + { + "input": "Definition: Anchoring cell junction described as a type of junction that attaches one cell to its neighbor. One of a number of differentiated regions which occur, for example, where the cytoplasmic membranes of adjacent epithelial cells are closely apposed. It consists of a circular region of each membrane together with associated intracellular microfilaments and an intercellular material which may include, for example, mucopolysaccharides.\nConcepts: CPEB3 protein, human (Biologically Active Substance)\tAruD (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)\tPulmonary venous stenosis (Finding)\tGrade 2 Growth suppression (Growth Suppression, CTCAE)\tdesmosome (Adherens Junction)", + "output": "desmosome (Adherens Junction)" + }, + { + "input": "Definition: Finding described as cutaneous melanoma in which the regional lymph nodes are not assessed (e.g., sentinel lymph node biopsy is not performed, regional lymph nodes were previously removed for another reason). Exception: pathological N category is not required for T1 melanomas, use cN. Presence of in-transit, satellite, and/or microsatellite metastases: No.\nConcepts: CSS04-Aborted Attempt-Life (Intellectual Product)\tcaffeine/coffee alkaloid (Homeopathic remedies letter C)\tGastrointestinal tube insertion (Therapeutic or Preventive Procedure)\tThermostable Nuclease (endodeoxyribonuclease)\tCutaneous Melanoma cNX TNM Finding v8 (Finding)", + "output": "Cutaneous Melanoma cNX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Primary malignant neoplasm of cornea described as a Kaposi sarcoma arising from the cornea.\nConcepts: 46,XY partial gonadal dysgenesis (Disease or Syndrome)\tIncandescence (Natural Phenomenon or Process)\tcorneal neoplasm kaposi's sarcoma (Malignant neoplasm of cornea)\tnegative regulation of oomycete sporangium development (negative regulation of sporangium development)\ttube feeding (Feeding Methods)", + "output": "corneal neoplasm kaposi's sarcoma (Malignant neoplasm of cornea)" + }, + { + "input": "Definition: something described as the process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth.\nConcepts: isotropic cell growth (Cell Function)\tSmith Fineman Myers syndrome (Intellectual Disability)\tHernia with Obstruction without Mention of Gangrene (Hernia)\tAt risk for perioperative thermal injury (At risk for perioperative injury)\tCSS04-Non-Spec Suicid Thought-Life (Intellectual Product)", + "output": "isotropic cell growth (Cell Function)" + }, + { + "input": "Definition: something described as an events domain that contains data that includes the subject's prior medical history at the start of the trial.\nConcepts: Medical History (Intellectual Product)\tOrphan Nuclear Receptors (TRANSCRIPTION FACTOR)\tpositive regulation of peptidyl-cysteine S-nitrosylation (regulation of peptidyl-cysteine S-nitrosylation)\t2: 219548961-219564457 (Chromosome 2 Physical Location)\tmeiotic metaphase I plate congression (Cell Function)", + "output": "Medical History (Intellectual Product)" + }, + { + "input": "Definition: WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered (WHODAS 2.0 12+24-item Version Interviewer-administered) Living situation at time of interview.\nConcepts: Short fifth metacarpal insulin resistance syndrome (Longitudinal deficiency of metacarpal bone)\tScoliosis and Kyphosis Deformity Correction (Therapeutic or Preventive Procedure)\tTheiloviruses (Virus)\tWD4-Living Situation at Interview (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tNelson bay reovirus (Virus)", + "output": "WD4-Living Situation at Interview (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: Aortic valve disorder described as congenital heart valve defects where the AORTIC VALVE has two instead of normal three cusps. It is often associated with AORTIC REGURGITATION and AORTIC INSUFFICIENCY.\nConcepts: Genomic Data Commons (Cancer Research)\tliberal arts (religion, humanities, and the arts)\tTyrosine modified diet (Modified amino acid diet)\tBICUSPID AORTIC VALVE (Congenital heart disease)\tReport (Intellectual Product)", + "output": "BICUSPID AORTIC VALVE (Congenital heart disease)" + }, + { + "input": "Definition: something described as macroautophagic degradation of PROTEASOMES.\nConcepts: Digital palpation of rectum (Medical Examination)\tproteaphagy (Cell Function)\tMericitabine (Antiviral Agents)\tTOP2BP1 (DNA Repair Gene)\tDAPORINAD (Organic Chemical)", + "output": "proteaphagy (Cell Function)" + }, + { + "input": "Definition: Abnormality of red blood cells described as a reticulocyte abnormality.\nConcepts: Episodic generalised hypotonia (Anatomical Abnormality)\tLimen nasi (Nose)\tprotein localization to cell surface (cellular protein localization)\tAbnormality of reticulocytes (Abnormality of red blood cells)\thistone acetyltransferase activity (H3 histone acetyltransferase activity)", + "output": "Abnormality of reticulocytes (Abnormality of red blood cells)" + }, + { + "input": "Definition: Disorder of renal parenchyma described as a developmental disorder of the kidney characterized by cystic dilatation of the medullary collecting ducts, resulting in a spongy gross appearance of the kidney. It may be asymptomatic or complicated by hematuria, infections, or renal stones.\nConcepts: AKT 1/2 Inhibitor BAY1125976 (AKT Inhibitor)\tdopachrome oxidoreductase activity (intramolecular oxidoreductase activity, transposing C=C bonds)\tpostsynaptic specialization membrane (Synaptic Membranes)\tSponge Kidney (Kidney)\thomeo n/lqd rem prep ea. 5mi (Health Care Activity)", + "output": "Sponge Kidney (Kidney)" + }, + { + "input": "Definition: Lipase measurement described as a measurement of the pancreatic triacylglycerol lipase in a biological specimen.\nConcepts: LIPASEP (Lipase measurement)\tregulation of cellular carbohydrate catabolic process (regulation of macromolecule metabolic process)\tImaging Genomics (Genomics)\tTRAP1 wt Allele (Gene or Genome)\tSymphoricarpos (Plant)", + "output": "LIPASEP (Lipase measurement)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a terminal branch arising from the bifurcation of the posterior inferior cerebellar artery that supplies the biventral and inferior semilunar lobes, the tonsil, and sometimes part of the superior semilunar lobe.\nConcepts: Tonsillohemispheric Artery (Body Part, Organ, or Organ Component)\tGenital Discomfort at its Worst (Intellectual Product)\tFIGO Stage IIIA1 (FIGO Stage IIIA)\tCDISC Questionnaire VFQ25-Self Administered Format Test Name Terminology (Intellectual Product)\tAnalyzers, Laboratory, Hematology, Cell Counting, Automated (Analyzers, Laboratory, Hematology, Cell Counting)", + "output": "Tonsillohemispheric Artery (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Functional Concept described as injection of a medicinal product into muscular tissue.\nConcepts: Blood Products Broker, Distributor, Warehouse (Manufactured Object)\tSmoked Cigarettes After Diagnosis and Before Treatment Start (Intellectual Product)\tcaspase-independent apoptosis (Molecular Function)\tIntramuscular (Musculoskeletal route)\tpM1 Cancer of the Uterus TNM Finding v6 (Uterine Corpus Cancer Pathologic Distant Metastasis TNM Finding v6)", + "output": "Intramuscular (Musculoskeletal route)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter B described as mi meng hua\nConcepts: Chlorhexidinum (Antiinfective irrigating solutions)\tkinesin II complex location (Cell Component)\tmedical speciality (field, discipline, or occupation)\tStage IVA Cervical Carcinoma FIGO 2018 (Neoplastic Process)\tBuddleia / mi meng hua (Plant)", + "output": "Buddleia / mi meng hua (Plant)" + }, + { + "input": "Definition: MEK Family Gene Mutation described as a change in the nucleotide sequence of the MAP2K2 gene.\nConcepts: NAT1 wt Allele (Gene or Genome)\tBrachydactyly of the foot (Finding)\tGrade 2 Vagus Nerve Disorder, CTCAE (Finding)\tRNF85 protein, human (Amino Acid, Peptide, or Protein)\tMEK2 Gene Mutation (MEK Family Gene Mutation)", + "output": "MEK2 Gene Mutation (MEK Family Gene Mutation)" + }, + { + "input": "Definition: something described as an anomaly of the metaphysis of the proximal femur (close to the hip).\nConcepts: Proximal femoral metaphyseal abnormality (Anatomical Abnormality)\tErythroblastic Leukemia, Acute (Myeloid Leukemia)\tTH 17 Cell (Helper-Inducer T-Lymphocyte)\tC-SSRS Children's Since Last Visit - Actual Suicide Attempt (C-SSRS Children's Since Last Visit Questionnaire Question)\tCLIN PROTOCOL (Therapeutic procedure)", + "output": "Proximal femoral metaphyseal abnormality (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as formation of melanin\nConcepts: HPH-3 (Gene or Genome)\tDislocation NEC-closed (Closed dislocation)\tMelanogenesis (Anabolism)\tCD4 Staining Method (Laboratory Procedure)\traloxifene hcl (Organic Chemical)", + "output": "Melanogenesis (Anabolism)" + }, + { + "input": "Definition: MCF2 gene described as human oncogene DBL is a mutated form of the MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, which encodes 4 alternative variants of the proto-oncogene DBL protein. Activation of the DBL oncogene is generated by 5-prime recombination with chromosome 3pter-p21 and by 3-prime recombination with chromosome 16p13-q22.\nConcepts: Unit of Electric Current Density (Quantitative Concept)\tMCF.2 cell line derived transforming sequence (Gene or Genome)\tAplasia/Hypoplasia of the cerebral white matter (Finding)\tchromatin-templated microtubule nucleation (microtubule nucleation)\tProstate Osteosarcoma (Prostate Sarcoma)", + "output": "MCF.2 cell line derived transforming sequence (Gene or Genome)" + }, + { + "input": "Definition: regulation of protein oxidation described as any process that stops, prevents or reduces the frequency, rate or extent of protein oxidation.\nConcepts: ebola virus (Virus)\tPTC4/RET Fusion Protein (Fusion protein)\tdown regulation of protein oxidation (negative regulation of protein modification process)\tHospital Central Supplies (Health Care Related Organization)\tPPA (DNA Polymerase Inhibitors)", + "output": "down regulation of protein oxidation (negative regulation of protein modification process)" + }, + { + "input": "Definition: Finding described as AIDS-related Kaposi sarcoma in which systemic illness is present; one or more of the following is true: history of opportunistic infections or thrush; one or more B symptoms is present; Karnofsky performance status score is under 70; other HIV-related illness is present, such as neurological disease or lymphoma.\nConcepts: Division Rhodophyta (Plants)\tI have weakness in my legs (Clinical or Research Assessment Question)\tAIDS-Related Kaposi Sarcoma S1 (AIDS-Related Kaposi Sarcoma S (Systemic Illness) Status)\tHand Sanitizer (Anti-Infective Agents, Local)\tStability Study Test Terminology (FDA Stability Data Standards Terminology)", + "output": "AIDS-Related Kaposi Sarcoma S1 (AIDS-Related Kaposi Sarcoma S (Systemic Illness) Status)" + }, + { + "input": "Definition: Liver Function Tests described as an elevated concentration of urobilinogen in the urine. []\nConcepts: OABQ0127 (Intellectual Product)\tSpinocerebellar ataxia type 30 (Disease or Syndrome)\tUrobilinogen urine increased (Abnormal urine urobilinogen level)\t17: 35853236-35867457 (Chromosome 17 Physical Location)\tGrade 1 Rash Acneiform, CTCAE (Finding)", + "output": "Urobilinogen urine increased (Abnormal urine urobilinogen level)" + }, + { + "input": "Definition: Body Location or Region described as a subdivision of the frontal lobe of the macaque defined on the basis of cytoarchitecture. It is a somewhat heterogeneous area that differs from area 46 of Walker by an absence of radial striations, a narrower internal granular layer, and a less orderly arrangement of cells. On the surface facing the longitudinal fissure, the cortex is thinner and cells in the third layer are smaller than in area 46 of Walker. Walker regarded the most likely cytoarchitectural homologue in the human to be area 9 of Brodmann-1909 (human) ( Walker-1940 ).\nConcepts: negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthesis (negative regulation of phosphatidylinositol biosynthetic process)\tLAMP, SURGICAL, INCANDESCENT (Medical Device)\tPsoas muscle, NOS (Prevertebral muscle)\tarea 9 of Walker (Body Location or Region)\tL-Serine (polar amino acids)", + "output": "area 9 of Walker (Body Location or Region)" + }, + { + "input": "Definition: sequence-specific double-stranded DNA binding described as interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA).\nConcepts: Recurrent Neuroendocrine Neoplasm (Recurrent tumor)\tIVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen)\tSubstance with B-Raf inhibitor mechanism of action (Amino Acid, Peptide, or Protein)\tobsolete AT binding (Genetic Function)\tAPCH1-15 Minus Glasgow Coma Score (APACHE II Clinical Classification Question)", + "output": "obsolete AT binding (Genetic Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the repression of both transcription and cell proliferation.\nConcepts: Stage II Major Salivary Gland Cancer (Neoplastic Process)\tBARS (Oxidoreductase Gene)\tMFIS - Less Able to Complete Tasks That Require Physical Effort (Intellectual Product)\tanaerobic ethylbenzene metabolic process (ethylbenzene metabolic process)\tAlpha2 (Statistical Significance)", + "output": "BARS (Oxidoreductase Gene)" + }, + { + "input": "Definition: Nutrient Intake described as the approximate intake in one day of liquid oral enteral nutrition supplements.\nConcepts: MAGE-1 Vaccinia Contaminated with BVDV (Vaccinia Vaccine)\tEstimated oral intake of nutritionally complete liquid supplement in 24 hours (Nutrient Intake)\tTumor Necrosis Factor Receptor Superfamily, Member 6B, Decoy wt Allele (TNFRSF6B gene)\tPalbociclib Isethionate (Organic Chemical)\tMass of axilla (Mass of body structure)", + "output": "Estimated oral intake of nutritionally complete liquid supplement in 24 hours (Nutrient Intake)" + }, + { + "input": "Definition: something described as catalysis of the reaction: benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + H(+) + NADPH.\nConcepts: Substance with oxygenase mechanism of action (Enzymes)\tbenzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tEimeria tenella (Eukaryote)\tHHS (Disease or Syndrome)\tAbacavir Sulfate/ Lamivudine (Anti-HIV Agents)", + "output": "benzyl-(2R,3S)-2-methyl-3-hydroxybutanoate:NADP+ 3-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Medical Device described as a medical insole is a device intended for medical purposes that is placed inside a shoe to relieve the symptoms of athlete's foot infection by absorbing moisture.\nConcepts: Stage IIA Mycosis Fungoides and Sezary Syndrome AJCC v8 (Neoplastic Process)\tAdvanced Pancreatic Adenocarcinoma (Pancreatic adenocarcinoma metastatic)\tINSOLES, MEDICAL (Medical Device)\tStage IIA Appendicular Skeleton, Trunk, Skull, and Facial Bones Cancer AJCC v8 (Neoplastic Process)\tBovine respirovirus 3 (Parainfluenza virus)", + "output": "INSOLES, MEDICAL (Medical Device)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.\nConcepts: BESUNIDE (Organic Chemical)\tAutoimmunity (IMMUNE SYSTEM: GENERAL TERMS)\tLSC (Clonal Hematopoietic Stem Cell)\tNEDOCROMIL (Carboxylic Acids)\tresponse to iron (response to metal ion)", + "output": "response to iron (response to metal ion)" + }, + { + "input": "Definition: something described as RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs.\nConcepts: Impact of Arm, Shoulder, or Hand Problem on Ability to Play Instrument or Sport (Intellectual Product)\tinjection of trigger point (Injection into body site)\ttRNA-type intron splice site recognition and cleavage (Genetic Function)\tRectal Neuroendocrine Tumor G2 (Colorectal Neuroendocrine Tumor G2)\tdichloroallyl lawsone (Organic Chemical)", + "output": "tRNA-type intron splice site recognition and cleavage (Genetic Function)" + }, + { + "input": "Definition: Pathologic Function described as a functional abnormality of neutrophils.\nConcepts: Impaired urinary elimination (Finding)\tuCalpain and friends in Cell spread (Cell Motility Pathway)\tAbnormality of neutrophil physiology (Pathologic Function)\tDigestive tract function, NOS (Physiology)\tTARP (Research Activity)", + "output": "Abnormality of neutrophil physiology (Pathologic Function)" + }, + { + "input": "Definition: Genetic Diseases, X-Linked described as a rare form of hereditary optic atrophy seen in only 4 families to date. With onset in early childhood the disease has characteristics of progressive loss of visual acuity, significant optic nerve pallor and occasionally additional neurological manifestations, with females being unaffected.\nConcepts: F18-EF5 (Indicator, Reagent, or Diagnostic Aid)\tIVD Test Reagent/Kits, Microbiology, Virus, Cell/Tissue Culture Media, Serum (Medical Device)\tDental Floss Holders (Medical Device)\tNon-Leber type optic atrophy with early-onset (Genetic Diseases, X-Linked)\tC130099 (Immunoglobulin measurement)", + "output": "Non-Leber type optic atrophy with early-onset (Genetic Diseases, X-Linked)" + }, + { + "input": "Definition: something described as ? , nrefers to a substructure of the medial pulvinar nucleus of the thalamus. It, the Nucleus pulvinaris medialis dorsalis (Hassler), the Nucleus pulvinaris medialis zentralis (Hassler) and the Nucleus pulvinaris medialis internus (Hassler) constitute the Nucleus pulvinaris medialis (Hassler) ( Jones-1990 ).\nConcepts: Determine (General information qualifier)\tWalking 50 steps/paces on flat ground at a normal speed without stopping (Intellectual Product)\tIQ Motif Containing GTPase Activating Protein 2 wt Allele (IQGAP2 gene)\tNucleus pulvinaris medialis ventralis (Body Part, Organ, or Organ Component)\tACCESSORY - FILM DOSIMETRY SYSTEM (Medical Device)", + "output": "Nucleus pulvinaris medialis ventralis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Health Care Activity described as facilitating experiential psychotherapy for a family member(s) using a synthesis of philosophies, techniques and approaches, to promote mindfulness and nonviolence and integrate the use of their bodies. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.\nConcepts: Absent coronary sinus (Congenital Heart Defects)\tOral and maxillofacial surgeon (Surgeon)\thakomi fam ea.15min (Health Care Activity)\tfluoxamine (Organic Chemical)\tImage Acquired (Intellectual Product)", + "output": "hakomi fam ea.15min (Health Care Activity)" + }, + { + "input": "Definition: Monosomy and deletion from autosome described as absence of one chromosome of one pair in an otherwise diploid cell of chromosome 22 associated with psychomotor retardation and multiple orofacial, digital, and other congenital anomalies.\nConcepts: tube formation (Organ or Tissue Function)\tDeletion 22 (Anomaly of chromosome pair 22)\tCSS04-Most Severe Idea, Duration-Life (Intellectual Product)\tNK Cell Lectin-Like Receptors (Amino Acid, Peptide, or Protein)\tStage IVB Mucosal Melanoma of the Head and Neck AJCC v7 (Neoplastic Process)", + "output": "Deletion 22 (Anomaly of chromosome pair 22)" + }, + { + "input": "Definition: Disease or Syndrome described as paratyphoid fever that is caused by infection with Salmonella enterica, serovar Paratyphi B.\nConcepts: pediatric large cell lymphoma, recurrent (Neoplastic Process)\tPneumocytes (Pulmonary alveolar structure)\tparatyphoid fever type B (Bacterial Infections)\tPlanned Inclusion Criterion (Idea or Concept)\tHomidium (Intercalating Agents)", + "output": "paratyphoid fever type B (Bacterial Infections)" + }, + { + "input": "Definition: something described as himalaya ProSelect(TM) Mentat 200 ml liquid. UPC Code 605069106313.\nConcepts: himalaya proselect mentat li (Clinical Drug)\tSUPERNATANT, CEREBROSPINAL FLUID (Body Substance)\tpathologic stage IIIB Merkel cell carcinoma AJCC v8 (Pathologic Stage III Merkel Cell Carcinoma AJCC v8)\tHmrp-2a (Chemokine Measurement)\tlycopene degradation (carotene catabolic process)", + "output": "himalaya proselect mentat li (Clinical Drug)" + }, + { + "input": "Definition: Finding described as retinoblastoma with tumor superficially invading optic nerve head but not extending past lamina cribrosa or tumor exhibiting focal choroidal invasion.\nConcepts: mesenchymal cell migration (Cell Function)\tUTP23, Small Subunit (SSU) Processome Component, Homolog (Yeast) wt Allele (UTP23 gene)\tRetinoblastoma pT2a TNM Finding v7 (Finding)\tanti-Met/EGFR monoclonal antibody LY3164530 (Monoclonal Antibodies)\tSkin Response Test (Diagnostic Procedure)", + "output": "Retinoblastoma pT2a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Viral Structural Proteins described as proteins found in the tail sections of DNA and RNA viruses. It is believed that these proteins play a role in directing chain folding and assembly of polypeptide chains.\nConcepts: ascospore wall (spore wall)\tTail Proteins, Virus (Viral Structural Proteins)\tO-(4-dimethylaminoethoxycinnamoyl)fumagillol (Organic Chemical)\tAlanine aminopeptidase measurement (Clinical Enzyme Tests)\tNMD Mutation (Mutation Abnormality)", + "output": "Tail Proteins, Virus (Viral Structural Proteins)" + }, + { + "input": "Definition: Cell Component described as a membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation.\nConcepts: Glossina (Eukaryote)\tthylakoid (cellular anatomical entity)\tKiller-Cell Lectin-Like Receptor Subfamily C 1/2 (Protein Family)\tOropharyngeal (p16-Negative) Cancer pTis TNM Finding v8 (Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8)\tImmunoglobulin A (Immunologic Factor)", + "output": "thylakoid (cellular anatomical entity)" + }, + { + "input": "Definition: Water purification filter described as water purification systems designed to remove charged particles (i.e., eliminate both cations and anions such as salts and metal ions) using deionization procedures. These systems consist of one or more containers (known as resin beds) that contain appropriate resins beads (both cationic and anionic) for the deionization procedure. There are systems using a mixed-bed, containing both cationic and anionic resins in a single vessel, and dual-bed systems, where each resin type is in a separate vessel. For most medical uses, including hemodialysis, mixed-bed systems should be used. Deionizers are frequently used after a reverse osmosis when ionic contamination is such that reverse osmosis (RO) alone cannot produce water of acceptable quality. Dedicated deionization systems used in hemodialysis procedures, both stand-alone and portable, are also available.\nConcepts: Fast Neutron Beam Radiotherapy Systems (Medical Device)\tNon-Neoplastic Ear Disease (Ear Diseases)\twatery stool (Bowel control, function)\tWater Purification Filters, Charcoal (Water purification filter)\tSuboptimal Gradient Artifact (Suboptimal Image Reason)", + "output": "Water Purification Filters, Charcoal (Water purification filter)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual's doctor knows the individual well as a person.\nConcepts: This doctor knows me well as a person (Clinical or Research Assessment Question)\ttolterodine l-tartrate (antienuresis agents)\tSH2B1 wt Allele (SH2B1 gene)\tGastrointestinal Neuroendocrine Tumor TNM Finding v7 (Digestive System Cancer TNM Finding v7)\tmenopause syndrome (Perimenopausal disorder)", + "output": "This doctor knows me well as a person (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Malignant neoplasm of nasal cavities, middle ear and accessory sinuses described as a primary or metastatic malignant neoplasm involving the frontal sinus.\nConcepts: Malig neop frontal sinus (Neoplastic Process)\tReticulocyte Distribution Width (Hematologic Tests)\tHepatoblastoma with Combined Fetal and Embryonal Epithelial Differentiation (Neoplastic Process)\tPopliteal Artery Below the Knee (Structure of popliteal artery)\tBilorin (Pharmacologic Substance)", + "output": "Malig neop frontal sinus (Neoplastic Process)" + }, + { + "input": "Definition: something described as the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.\nConcepts: Client Computer (Computers)\tAttachment, Dental Slotted (Dental Attachments)\tUnconventional Western System (Occupation or Discipline)\tcell migration involved in sprouting angiogenesis (Cell Function)\tDucts, Nasolacrimal (Lacrimal drainage structure)", + "output": "cell migration involved in sprouting angiogenesis (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins.\nConcepts: Oxycodone Hydrochloride/Naloxone Hydrochloride Prolonged-release Tablet (Opioid Receptor Agonist)\tSpinster (Family Related Social States)\ttransport vesicle lumen (cytoplasmic vesicle lumen)\tDOXYCYCLINE (Tetracycline Antibiotics)\tsialyltransferase activity (glycosyltransferase activity)", + "output": "sialyltransferase activity (glycosyltransferase activity)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of smooth muscle hypertrophy.\nConcepts: small inducible cytokine subfamily A (Cys-Cys), member 20 (CC Cytokine Gene)\tregulation of smooth muscle hypertrophy (regulation of muscle hypertrophy)\tEffects, Psychosocial (Finding)\tHaemorrhage ant chamber eye (Vision Disorders)\tHSXIAPAF1 (Apoptosis Promoter Gene)", + "output": "regulation of smooth muscle hypertrophy (regulation of muscle hypertrophy)" + }, + { + "input": "Definition: BACTERIA AND RICKETTSIAE described as a genus of PASTEURELLACEAE described as gram-negative, nonsporeforming, nonmotile, facultative anaerobes. Most members are found both as pathogens and commensal organisms in the respiratory, alimentary, and genital tracts of animals.\nConcepts: Actinobacillus species (Gram-Negative Facultatively Anaerobic Rods)\tPP/PE Sutures (Sutures, Synthetic, Nonabsorbable)\tmitochondrial ADP transmembrane transport (anion transmembrane transport)\tRARA (RARA Gene Product)\tGrade 2 Small Intestinal Stenosis, CTCAE (Finding)", + "output": "Actinobacillus species (Gram-Negative Facultatively Anaerobic Rods)" + }, + { + "input": "Definition: Intellectual Product described as a unique symbol that establishes identity of the experimental unit. EXAMPLE(S): patient number 7 on a study OTHER NAME(S): NOTE(S):\nConcepts: Testicular Yolk Sac Tumor, Microcystic Pattern (Neoplastic Process)\tAbnormal shape of hindbrain (Anatomical Abnormality)\tSample Viability Indicator (Conceptual Entity)\tExperimental Unit Identifier (Intellectual Product)\tEntacapona (Other dopaminergic agents in ATC)", + "output": "Experimental Unit Identifier (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate.\nConcepts: CAMFAK - Cereb-ocul-fac-sk syn (Syndrome)\tScar tissue (Pathologic Function)\tprotein amino acid demethylation (protein dealkylation)\tcytoskeletal regulatory protein binding (cytoskeletal protein binding)\tUDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity (Molecular Function)", + "output": "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity.\nConcepts: sbsqnt 45min xofc ptrn ntak (Health Care Activity)\tLDH Isoenzyme 4/LDH (Laboratory Procedure)\tJAK2 Protein Variant (Cell or Molecular Dysfunction)\tgroup II metabotropic glutamate receptor activity (Molecular Function)\tfatty acid derivative catabolic process (fatty acid derivative metabolic process)", + "output": "group II metabotropic glutamate receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as a test to determine if a patient has hyper-responsive airways.\nConcepts: Histamine Challenge Test (Pulmonary function tests)\tH2B/j (Histone H2b)\tLiver Surgery Patient (Patient or Disabled Group)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Helicobacter Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)\tAccessory spleen (Congenital Abnormality)", + "output": "Histamine Challenge Test (Pulmonary function tests)" + }, + { + "input": "Definition: Oxidoreductase described as ribosyldihydronicotinamide dehydrogenase [quinone] (231 aa, ~26 kDa) is encoded by the human NQO2 gene. This protein is involved in the metabolism of quinone-containing compounds.\nConcepts: telepathy (Mental Process)\tUndefined existing client home-visit with ICD diagnosis narrative required (Existing client home-visit with ICD diagnosis)\tDetailed subsequent 30 minutes in-office Oriental medicine intake (Existing client in-office without ICD diagnosis)\tQuinone Reductase 2 (Amino Acid, Peptide, or Protein)\t3q13.12 (Cell Component)", + "output": "Quinone Reductase 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.\nConcepts: 14: 74815284-74818666 (Spatial Concept)\tNPI1A02 (NPI Questionnaire Question)\tlobster claw (Superfamily Nephropoidea)\tlength umbilical cord (Finding of measures of umbilical cord)\tnorepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure (Organ or Tissue Function)", + "output": "lobster claw (Superfamily Nephropoidea)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of reuteran, a soluble glucan polymer with mainly alpha-(1->4) glycosidic linkages and significant amounts of alpha-(1->6) and alpha-(1->4,6) glucosidic linkages.\nConcepts: amygdaloid corticomedial complex (Body Part, Organ, or Organ Component)\tFPR (Gene or Genome)\treuteran biosynthetic process (reuteran metabolic process)\tsodium/iodide symporter activity (anion:sodium symporter activity)\tHypertrichosis, CTCAE (Skin and Subcutaneous Tissue Disorders, CTCAE)", + "output": "reuteran biosynthetic process (reuteran metabolic process)" + }, + { + "input": "Definition: Receptor described as a pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.\nConcepts: Conditions (Property or Attribute)\tlysophosphatidylethanolamine acyltransferase activity (lysophospholipid acyltransferase activity)\tResult Classification Type Code (Intellectual Product)\tReceptor, TLR2 (Toll-like receptors)\tSkin cancer, Kaposi sarcoma (Neoplasms)", + "output": "Receptor, TLR2 (Toll-like receptors)" + }, + { + "input": "Definition: something described as paced Tapping Test (Paced Tapping) The average signed deviation of the intertap intervals within the self-paced tapping phase across all trials.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking Up 30 Stairs (Intellectual Product)\tcell brain (Cells)\tPTAP107H (Paced Tapping Functional Test Question)\thealthcare delivery (Treatment (General))\tcolloid cysts (Central Nervous System Cysts)", + "output": "PTAP107H (Paced Tapping Functional Test Question)" + }, + { + "input": "Definition: Medical Device described as equipment designed to make temporary pores in cell plasma membranes by applying an appropriate (usually several hundred volts) external voltage (i.e., electric potential) that is higher than the dielectric strength of the membrane, allowing extracellular compounds foreign genes (e.g., plasmids - extra-chromosomal self-replicating structures carrying genes) and/or protein material to penetrate into the cell while the membrane is porous. Laboratory electroporators typically consist of a generator that delivers electric current to electrodes placed inside cuvettes and a solution containing the cells (e.g., bacteria cells). Plasmids are introduced into the cuvette, and the electric voltage is applied to the electrodes. After the electroporation procedure, the cells are incubated to produce new cells, which include the reproduced plasmids. Dedicated electroporators for laboratory transfection of DNA into mammalian cells and/or the transformation of cells into bacteria/yeast and other devices intended for in vivo introduction of genes into cells (e.g., through the skin) during gene therapy and/or tumor treatment are also available.\nConcepts: Lipid Binding (Binding)\tElectroporators (In Vitro Diagnostics and Laboratory Equipment)\tSynthase, Thromboxane A (Amino Acid, Peptide, or Protein)\tSmoothened Antagonist LDE225 Topical (Pharmacologic Substance)\tpovidone-iodine solution (Clinical Drug)", + "output": "Electroporators (In Vitro Diagnostics and Laboratory Equipment)" + }, + { + "input": "Definition: something described as radiographic/fluoroscopic chairs with radiolucent head- and backrest sections and positioning capabilities that enable the head and trunk x-ray procedures in patients with difficulty in swallowing (dysphagia), head and trunk injuries, or any other condition which requires these procedures.\nConcepts: Lugano Classification Limited Stage Childhood Hodgkin Lymphoma AJCC v8 (Lugano Classification Childhood Hodgkin Lymphoma by AJCC v8 Stage)\t3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity (carboxy-lyase activity)\tpT2 Uterine Carcinoma TNM Finding v6 (Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6)\tHAMD205 (Intellectual Product)\tChairs, Radiography/Fluoroscopy, Head/Torso (Medical Device)", + "output": "Chairs, Radiography/Fluoroscopy, Head/Torso (Medical Device)" + }, + { + "input": "Definition: something described as one type B characteristic, which characteristics include length 10-20 mm, eccentric, moderate to heavy calcification, and the presence of some thrombus.\nConcepts: biodegradable implants (Prostheses and Implants)\tType B1 (Classification)\tViral Inclusions Present (Finding)\tReferenceToStudyResults.linkPageDescription (Intellectual Product)\tRefractory cancer (Neoplasms malignant site unspecified NEC)", + "output": "Type B1 (Classification)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - Before deployment: I went through a divorce or was left by a significant other.\nConcepts: quinoline 2-oxidoreductase activity (oxidoreductase activity, acting on the CH-CH group of donors)\tNortriptyline hydrochloride [enuresis - no agents here] (dibenzocycloheptene)\tcodeine:NADP+ oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tDRRI-2 - A: Went Through Divorce/Was Left (Intellectual Product)\tMajor Salivary Gland Carcinoma cM0 TNM Finding V8 (Major Salivary Gland Cancer Clinical Distant Metastasis TNM Finding v8)", + "output": "DRRI-2 - A: Went Through Divorce/Was Left (Intellectual Product)" + }, + { + "input": "Definition: Sociological Factors described as a subgroup having special characteristics within a larger group, often bound together by special ties which distinguish it from the larger group.\nConcepts: Minority (Sociology)\tNasal Cavity and Ethmoid Sinus Cancer pT2 TNM Finding v6 and v7 (Nasal Cavity and Ethmoid Sinus Cancer Pathologic Primary Tumor TNM Finding v6)\tADNI AVLT - List A Recall 6 (After B) Word 8 (ADNI-AVLT Questionnaire Question)\tBarbiturate product (Central Nervous System Depressants)\tGrade 2 Cardiac Disorders - Other, Specify, CTCAE (Cardiac Disorders - Other, Specify, CTCAE)", + "output": "Minority (Sociology)" + }, + { + "input": "Definition: Spatial Concept described as physical location of CNK1_Gene\nConcepts: 2-heptyl-3-hydroxy-4(1H)-quinolone synthase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tthird stage of labor (Labor finding)\t1: 26188145-26200517 (Chromosome 1 Physical Location)\tCorydalis (Plant)\tAnilinoazobenzene (Organic Chemical)", + "output": "1: 26188145-26200517 (Chromosome 1 Physical Location)" + }, + { + "input": "Definition: Medical Device described as devices into which samples are placed for testing or temporary storage. Collectors are typically made of plastic, metal, or glass.\nConcepts: Language impairment (Communication impairment)\tPCHGBL (Percent)\tpyrogen (Organic Chemical)\tCollectors (Medical Device)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Hantavirus (Medical Device)", + "output": "Collectors (Medical Device)" + }, + { + "input": "Definition: something described as a specialist who treats decompression illness and diving accident cases and uses hyperbaric oxygen therapy to treat such conditions as carbon monoxide poisoning, gas gangrene, non-healing wounds, tissue damage from radiation and burns, and bone infections. This specialist also serves as a consultant to other physicians in all aspects of hyperbaric chamber operations, and assesses risks and applies appropriate standards to prevent disease and disability in divers and other persons working in altered atmospheric conditions.\nConcepts: Uterine Corpus Carcinoma pTX TNM Finding v7 (Finding)\tAllopathic & Osteopathic Physicians; Emergency Medicine, Undersea and Hyperbaric Medicine (Professional or Occupational Group)\tPGDH3 (Gene or Genome)\t4q21.2 (Chromosome band)\tMGC921 (H2AJ Gene)", + "output": "Allopathic & Osteopathic Physicians; Emergency Medicine, Undersea and Hyperbaric Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as YAC based content mapping is a clone-based physical genome mapping strategy. Content mapping is done by ordering sequence tagged sites (STS), regions of the genome which can be uniquely identified, and YAC (Yeast Artificial Chromosome) clone ends along the chromosome, based on the STS content of each clone, for constructing a composite map that represents the linear order and position of mapping landmarks along the genome.\nConcepts: YAC-Based STS-Content Mapping (Clone-Based Physical Mapping)\tBiotechnologies (Biomedical Occupation or Discipline)\tHearing Aid Cleaning Brushes (Brushes, Cleaning)\tAgranular frontal area 6 (Body Part, Organ, or Organ Component)\tDihydrostilbenoids (Bibenzyls)", + "output": "YAC-Based STS-Content Mapping (Clone-Based Physical Mapping)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a folate receptor-targeting radiopharmaceutical consisting of a folate-containing tetrapeptide chelator to which technetium Tc 99m is linked. The folate component of folate receptor-targeted technetium Tc 99m EC20 binds to folic acid receptors, which are frequently upregulated in many types of tumor cells and activated macrophages. Gamma scintigraphy may then be used to image folate receptor-positive tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C66986\" active clinical trials using this agent.\nConcepts: Technetium Tc 99m EC20 (Indicator, Reagent, or Diagnostic Aid)\tPhosphoramides (Organic Chemical)\tDeath-Like Domains (Amino Acid Sequence)\tEmbolism NOS (Vascular occlusion)\tAbnormal factor V activity (Pathologic Function)", + "output": "Technetium Tc 99m EC20 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Immunologic Factor described as one of a number human monoclonal antibodies of the immunoglobulin subclass IgG2a directed against melanoma antigens with potential antineoplastic activity. A melanoma monoclonal antibody, subclass IgG2A, may have potential use as a diagnostic agent and, therapeutically, may induce macrophage-mediated cytotoxicity against antibody-bound melanoma cells.\nConcepts: Meal Data Elapsed Time (Elapsed Time)\tMelanoma Monoclonal Antibody hIgG2A (Monoclonal Antibodies)\tCalifornia Peppertree (Anacardiaceae)\tnegative regulation of animal organ morphogenesis (negative regulation of multicellular organismal process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SGCD (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "Melanoma Monoclonal Antibody hIgG2A (Monoclonal Antibodies)" + }, + { + "input": "Definition: Drug Administration Routes described as a route that begins in the eye region.\nConcepts: Ophthalmic Route of Administration (Ophthalmic Route of Drug Administration)\tbeak morphogenesis (Organ or Tissue Function)\tADNI AVLT - List A Recall 6 (After B) Word 14 (Intellectual Product)\trac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity (phosphoric diester hydrolase activity)\tDRRI1L01 (DRRI-2 Questionnaire Question)", + "output": "Ophthalmic Route of Administration (Ophthalmic Route of Drug Administration)" + }, + { + "input": "Definition: Computed Ethnicity Source Code described as a coded value specifying the database, method, or computer algorithm that was used to determine ethnicity as recorded in the Computed Ethnicity Code. [adapted from NCI SEER Program Coding and Staging Manual 2015] EXAMPLE(S): For the U.S. National Cancer Institute (NCI) Surveillance, Epidemiology, and End Results (SEER) program: 0 = No match [linkage] was run for 1994 and later cases 1 = Census Bureau list of Spanish surnames, NOS 2 = 1980 Census Bureau list of Spanish surnames 3 = 1990 Census Bureau list of Spanish surnames 4 = GUESS program 5 = Combination list including South Florida names 6 = Combination of Census and other locally generated list 7 = Combination of Census and GUESS, with or without other lists 8 = Other type of match (Do not record results of NHIA in this field) 9 = Unknown type of match Blank = 1993 and earlier cases, no match [linkage] was run OTHER NAME(S): NOTE(S): For SEER, blank is allowed only for tumors diagnosed in 1993 and earlier.\nConcepts: Vasopressin Receptor Binding (G protein-coupled receptor binding)\tPerson.computedEthnicitySourceCode (Intellectual Product)\tregulation of snRNA pseudouridine synthesis (Genetic Function)\tregulation of branching involved in lung morphogenesis (regulation of morphogenesis of an epithelium)\tFocal aware cognitive seizure with hallucination (Disease or Syndrome)", + "output": "Person.computedEthnicitySourceCode (Intellectual Product)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.\nConcepts: Grade 2 Rectal hemorrhage (Finding)\tRPA32 (DNA Repair Gene)\tsignaling receptor ligand precursor processing (cellular process)\tPudding Dosage Form (Biomedical or Dental Material)\tommochrome metabolic process (ocellus pigment metabolic process)", + "output": "ommochrome metabolic process (ocellus pigment metabolic process)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of frequency expressed as the percentage of entities or events per minute.\nConcepts: catheters swan-ganz (Pulmonary artery flotation catheter)\tMIR199A1 (Gene or Genome)\tCis-dichloroammine Platinum (Chlorine Compounds, Inorganic)\tStriate Body (Telencephalon)\t%/min (Miscellaneous Unit)", + "output": "%/min (Miscellaneous Unit)" + }, + { + "input": "Definition: Class Cestoda described as a genus of cyclophyllid tapeworms in the family Taeniidae. The definitive hosts for echinococcus are carnivorous predators; humans become by zoonotic transfer. Infection with Echinococcus results in hydatid disease, also known as echinococcosis.\nConcepts: worm hydatid (Eukaryote)\tTrial Termination (Finding)\tCCR9 chemokine receptor binding (Molecular Function)\tregulation of ERAD (regulation of ERAD pathway)\tHBA1B (Laboratory Procedure)", + "output": "worm hydatid (Eukaryote)" + }, + { + "input": "Definition: something described as a well differentiated, intermediate grade tumor with neuroendocrine differentiation that arises from the extrahepatic bile ducts. The mitotic count is 2-20 per 10 HPF and/or the Ki67 index is 3 to 20 percent.\nConcepts: Testicular Yolk Sac Tumor, Microcystic Pattern (Testicular yolk sac tumor)\tImmersion Investigative Technique (Diagnostic Procedure)\tObesity-Associated Insulin Resistance (Disease or Syndrome)\tExtrahepatic Bile Duct Neuroendocrine Tumor G2 (Neoplastic Process)\tM6a (Neoplastic Process)", + "output": "Extrahepatic Bile Duct Neuroendocrine Tumor G2 (Neoplastic Process)" + }, + { + "input": "Definition: something described as a protein complex that consists of the intracellular domain of Notch4 (ICN4), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-3 (MAML3); the complex is involved in transcriptional activation in response to Notch-mediated signaling.\nConcepts: MAML3-RBP-Jkappa-ICN4 complex location (Cell Component)\tDioscoreae bulbiferae / huang yao zi (Plant)\tTeeth, Impacted (Systematized Nomenclature of Dentistry)\tareas (Kind of quantity)\tLow saturated fat diet (Fat-Restricted Diet)", + "output": "MAML3-RBP-Jkappa-ICN4 complex location (Cell Component)" + }, + { + "input": "Definition: Academic Research Council Coronary Stent Thrombosis Timing described as the formation of a clot within a stent less than 24 hours after the stent is placed.\nConcepts: RBP-Jkappa protein, human (Amino Acid, Peptide, or Protein)\t1-18:2-2-18:3-phosphatidylcholine desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)\tAbnormal flow cytometry test result (Abnormal cellular phenotype)\tAcademic Research Council Acute Stent Thrombosis (Finding)\tcell membrane microparticle (Cell Component)", + "output": "Academic Research Council Acute Stent Thrombosis (Finding)" + }, + { + "input": "Definition: Finding described as the percent of cells that were blasts in the subject's bone marrow used to make the response assessment.\nConcepts: Macrostomia (Orofacial cleft)\tBM PCT Blasts At Response (Clinical or Research Assessment Answer)\tGrade 1 Neonatal Hypertension, Adverse Event (Finding)\ttranquilizers antianxiety (USP Medicare Model Guidelines)\tmicromoles (Potency Unit)", + "output": "BM PCT Blasts At Response (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Opportunistic Infections described as a viral infection that fails to be contained by the immune sytem and spreads throughout the body.\nConcepts: Becker's naevus (Hyperpigmentation)\tAge-Months (Age)\tWest Nile Virus (Molecular Function)\tDisseminated viral infection (Opportunistic Infections)\tQLES205 (Intellectual Product)", + "output": "Disseminated viral infection (Opportunistic Infections)" + }, + { + "input": "Definition: Endocrine neoplasms malignant and unspecified NEC described as neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.\nConcepts: Solid Tumor (Neoplastic Process)\tPituitary Neoplasm (location of neoplasm of sella turcica)\tintermediate layer of spindle pole body (cellular anatomical entity)\tDiphtheria Toxin-Human Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein (Pharmacologic Substance)\tORGANOSELENIUM CPDS (Organic Chemical)", + "output": "Pituitary Neoplasm (location of neoplasm of sella turcica)" + }, + { + "input": "Definition: Serine/Threonine Protein Kinase Gene described as this gene plays a role in cell survival and the negative regulation of cell growth.\nConcepts: rndx rape trauma syndrome (Post-trauma response)\tINTERFERON REGULATORY FACTOR 5 (Transcription Coactivator Gene)\tCHEK2 Gene (Gene or Genome)\tPODCI3-Games Limited by: Instructions (PODCI Adolescent Self-Reported Version Questionnaire Question)\tCleland Reagent (Pharmacologic Substance)", + "output": "CHEK2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Potency Unit described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form or container is a type of pouch. Comment: For example, to describe the strength of a pouch: \"contains 10 mg per pouch\".\nConcepts: transduction (Virus Physiological Phenomena)\thypophosphataemia (Abnormal blood phosphate concentration)\tamitriptyline hydrochloride (dibenzocycloheptene)\tSmall Intestinal Carcinoma by AJCC v7 Stage (Small intestine carcinoma)\t{POUCH} (Quantitative Concept)", + "output": "{POUCH} (Quantitative Concept)" + }, + { + "input": "Definition: Disease Grade Qualifier described as no symptoms.\nConcepts: LRMSC Grade 0 Subcutaneous Tissue (Intellectual Product)\tformation by organism of specialized structure for nutrient acquisition from host (development of symbiont involved in interaction with host)\tGalactitol, 1,2:5,6-dianhydro- (Epoxide Compound)\tNasal rongeur (Medical Device)\tviral RNA genome packaging (Cell Function)", + "output": "LRMSC Grade 0 Subcutaneous Tissue (Intellectual Product)" + }, + { + "input": "Definition: Existing client in-office without ICD diagnosis described as using Native American Healing assessment methods in a simple, subsequent, 15-minute, in-office meeting to assess the health status of an existing Native American Healing client to reevaluate and/or develop a Native American Healing treatment plan.\nConcepts: Cartilages (Anatomical set)\tBetacoccus arabinosaceus (Leuconostoc)\tExpected Indicator (Indicator)\tSimple subsequent 15 minutes in-office Native American Healing intake (Health Care Activity)\thexadecanal synthesis (Molecular Function)", + "output": "Simple subsequent 15 minutes in-office Native American Healing intake (Health Care Activity)" + }, + { + "input": "Definition: ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory - If yes, which best describes his/her highest level of performance.\nConcepts: 11: 2139000-2137585 (Spatial Concept)\tInferior rectus muscle restriction (Disease or Syndrome)\tSF-36 v2.0 Acute - Question 3b (SF36 v2 0 Acute Questionnaire Question)\tNon-specified HCPCS II telehealth transmission or procedure reference code no charge (Health Care Activity)\tADCS-ADL - Description of Highest Performance of Telephone Use (Intellectual Product)", + "output": "ADCS-ADL - Description of Highest Performance of Telephone Use (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as narrowing of peripheral arteries with reduction of blood flow to the limbs. This feature may be quantified as an ankle-brachial index of less than 0.9, and may be manifested clinically as claudication. []\nConcepts: MYOR (Transcription factor genes)\tPeripheral arterial stenosis (Disease of non-coronary systemic artery)\tpluripotent (General Qualifier)\tdovitinib lactate (Antineoplastic Enzyme Inhibitor)\tDefinedSubstanceAdministration.doseRegimen (Dose Regimen)", + "output": "Peripheral arterial stenosis (Disease of non-coronary systemic artery)" + }, + { + "input": "Definition: phloroglucinol described as a natural dihydrochalcone found in apples and many other fruits.\nConcepts: Unidentified Sentinel Lymph Node (Other Finding)\tKHOISAN (Population Group)\tdrugs prescriptions (prescription document)\tXenopsylla (Fleas)\tphloretin (P [Preparations])", + "output": "phloretin (P [Preparations])" + }, + { + "input": "Definition: C [Preparations] described as an alkylamide found in CAPSICUM that acts at TRPV CATION CHANNELS.\nConcepts: Capsaicin-containing product (Counterirritants)\tBCL6/LCP1 FUSION GENE (Fusion Gene)\tHUGO ID (Conceptual Entity)\t4: 1232621-1195118 (Chromosome 4 Physical Location)\tRespiratory Therapist (Allied Health Profession)", + "output": "Capsaicin-containing product (Counterirritants)" + }, + { + "input": "Definition: Cell Component described as the best understood cell-cell junction required for adhesion between cells in the epithelium. It seals adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. Adherens junctions are located most apically in insect cells and just basal to the tight junction in vertebrate cells. It is formed by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence based on homophilic association between molecules of the transmembrane protein E-cadherin, which is linked on its cytoplasmic side to the actin cytoskeleton via b-catenin (Drosophila Armadillo) and a-catenin. The adherens junctions and associated cytoskeleton form a continuous band (zonula adherens) around the apical circumference of each cell, thus uniting the cells of the epithelium into a coherent sheet.\nConcepts: aspyridone A metabolic process (pyridine-containing compound metabolic process)\tPhysical therapy table (Medical Device)\tEmergency (Phenomenon or Process)\tSeminal Vesicle Biopsy (SCROTUM, VAS DEFERENS AND SEMINAL VESICLE: EXCISIONS)\tAdherens Junction (Cell to cell adherens junction)", + "output": "Adherens Junction (Cell to cell adherens junction)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as zinc finger protein 423 (1284 aa, ~145 kDa) is encoded by the human ZNF423 gene. This protein is involved in differentiation of olfactory receptor neurons.\nConcepts: GM2 Ganglioside (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)\tFunctional Pituitary Microadenoma (Pituitary Gland Microadenoma)\tSmad- and Olf-Interacting Zinc Finger Protein (Amino Acid, Peptide, or Protein)\tHand Digit 4 (Upper Extremity)\tallantoinase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides)", + "output": "Smad- and Olf-Interacting Zinc Finger Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Component described as a protein complex that consists of an alpha5-beta1 integrin complex bound to lipid phosphate phosphohydrolase-3.\nConcepts: alpha5-beta1 integrin-LPP3 complex (plasma membrane protein complex)\tEstimated parenteral intake of carbohydrate in 24 hours (Quantitative Concept)\tN-trimethylglycine-transporting ATPase activity (amino-acid betaine transmembrane transporter activity)\tPhysiologic Cardiac Test Stimulators (Medical Device)\tAcetyltransferase, NatC N-Terminal (Enzyme)", + "output": "alpha5-beta1 integrin-LPP3 complex (plasma membrane protein complex)" + }, + { + "input": "Definition: something described as entamoeba histolytica serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Entamoeba histolytica in serum. Additionally, some of these reagents consist of antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify Entamoeba histolytica directly from clinical specimens. The identification aids in the diagnosis of amebiasis caused by the microscopic protozoan parasite Entamoeba histolytica and provides epidemiological information on diseases caused by this parasite. The parasite may invade the skin, liver, intestines, lungs, and diaphragm, causing disease conditions such as indolent ulcers, an amebic hepatitis, amebic dysentery, and pulmonary lesions.\nConcepts: chromatin modelling (chromatin organization)\tTriangular shaped middle pinkie finger bone (Triangular shaped middle phalanges of the hand)\tC3H1 Zinc Finger (Amino Acid Sequence)\tGIARDIA SPP. (Medical Device)\trough endoplasmic reticulum to cis-Golgi targeting (Cell Function)", + "output": "GIARDIA SPP. (Medical Device)" + }, + { + "input": "Definition: Free Radicals described as molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule.\nConcepts: streptococcus mitis (Bacterium)\tspin labels (Indicator, Reagent, or Diagnostic Aid)\tPUERTO RICO (Country)\tCoronavirus, Feline Enteric (Non human viruses)\tMelittin (Antimicrobial Cationic Peptides)", + "output": "spin labels (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as zinc finger protein GLIS2 (524 aa, ~56 kDa) is encoded by the human GLIS2 gene. This protein is involved in the regulation of transcription and the repression of signaling pathways.\nConcepts: Apolipoprotein B 48 (Apolipoproteins B)\tshoot system development (Organ or Tissue Function)\tTacrolimus (Calcineurin inhibitor)\tZinc Finger Protein GLIS2 (Amino Acid, Peptide, or Protein)\tMLL-AF9 Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "Zinc Finger Protein GLIS2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Manufactured Object described as a vial used to store specimens in a cryopreservative at very low temperatures.\nConcepts: cerebrospinal fluid diversion (Therapeutic procedure)\tManagement, Continuous Quality (Occupational Activity)\tClerodendrums (Verbenaceae)\tRB Tumor Suppressor/Checkpoint Signaling in response to DNA damage (Cell Function)\tCryovial (Manufactured Object)", + "output": "Cryovial (Manufactured Object)" + }, + { + "input": "Definition: Structure of vein of lower extremity described as a vein in the foot that is formed by the union of the external and internal plantar veins and which becomes the popliteal vein.\nConcepts: stillbirths (BODY AS A WHOLE - GENERAL DISORDERS)\tSCID, NOS (Congenital Immunodeficiency Diseases)\tLongitudinally grooved fingernails (Abnormal fingernail morphology)\tPosterior tibial veins (Structure of tributary of popliteal vein)\tIneffective hematopoiesis (Abnormal hematopoiesis)", + "output": "Posterior tibial veins (Structure of tributary of popliteal vein)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of concentration equal to grams per milliliter, divided by micrograms.\nConcepts: Codeine Sulfate (Phenanthrenes)\tmale courtship behavior, tapping to detect pheromone (male courtship behavior)\tFe(II):NADP+ oxidoreductase activity (oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor)\tElectrocardiogram Time Point (Timepoint)\tg/mL/ug (Unit of concentration)", + "output": "g/mL/ug (Unit of concentration)" + }, + { + "input": "Definition: Medical Device described as a radionuclide brachytherapy source is a device that consists of a radionuclide which may be enclosed in a sealed container made of gold, titanium, stainless steel, or platinum and intended for medical purposes to be placed onto a body surface or into a body cavity or tissue as a source of nuclear radiation for therapy.\nConcepts: Workstations, Gamma Camera/Single Photon Emission Tomography (Workstation)\tStage IIIA Esophageal Adenocarcinoma (Pathologic Stage III Esophageal Adenocarcinoma AJCC v8)\tLEGIONELLA PNEUMOPHILA SEROGROUP 6 (Legionella pneumophila)\tSOURCE, BRACHYTHERAPY, RADIONUCLIDE (Medical Device)\tNon-specified HCPCS II mammography reference code no charge (Tracking code use with or without ICD diagnosis)", + "output": "SOURCE, BRACHYTHERAPY, RADIONUCLIDE (Medical Device)" + }, + { + "input": "Definition: something described as fallopian tube cancer with distant metastasis (excluding metastasis within the peritoneal cavity).\nConcepts: ANGPT1 Measurement (Laboratory Procedure)\tcytoplasmic stress granule (Cell Component)\tFallopian Tube Cancer cM1 TNM Finding v7 (Fallopian Tube Cancer Clinical Distant Metastasis TNM Finding v7)\tHDL Cholesterol to Total Cholesterol Ratio Measurement (Lipids measurement)\tnegative regulation of RIG-I signaling pathway (negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway)", + "output": "Fallopian Tube Cancer cM1 TNM Finding v7 (Fallopian Tube Cancer Clinical Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: Cell Function described as a process in which iron is solubilized by reduction from Fe3+ to Fe2+ via a cell surface reductase and subsequent transport of the iron across the membrane by iron uptake proteins.\nConcepts: Conducting system of interventricular septum (Conducting system of cardiac septum)\tCause of Death (Qualifier for type of diagnosis)\tdown regulation of T cell tolerance induction to tumor cell (negative regulation of peripheral T cell tolerance induction)\tIVD Test Reagent/Kits, Immunoassay, Endocrine Hormone, Growth Hormone (Medical Device)\tiron assimilation by reduction and transport (iron import into cell)", + "output": "iron assimilation by reduction and transport (iron import into cell)" + }, + { + "input": "Definition: regulation of endothelial cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of endothelial cell differentiation.\nConcepts: downregulation of endothelial cell differentiation (regulation of endothelial cell differentiation)\tatrial cardiomyocyte differentiation (cardiac muscle cell differentiation)\tUrogenital ridge structure (embryo and fetus)\tPRELTM (Elapsed Time)\tNPI1L04 (Intellectual Product)", + "output": "downregulation of endothelial cell differentiation (regulation of endothelial cell differentiation)" + }, + { + "input": "Definition: something described as lip cancer with tumor invading through cortical bone, inferior alveolar nerve, floor of mouth or skin of face (i.e. chin or nose). Superficial erosion of bone or tooth socket by a gingival primary tumor is not sufficient to classify as T4.\nConcepts: columnar/cuboidal epithelial cell differentiation (Cell Function)\tMental Retardation, X-Linked, With Short Stature, Small Testes, Muscle Wasting, And Tremor (Intellectual Disability)\tHave Hiccups (Clinical or Research Assessment Question)\tLip and Oral Cavity Cancer pT4 TNM Finding v6 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v6)\tPerque(TM) Osteo-4 Restore bone and joint formula (Pharmacologic Substance)", + "output": "Lip and Oral Cavity Cancer pT4 TNM Finding v6 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v6)" + }, + { + "input": "Definition: Qualitative Concept described as information regarding the subject is unknown or inaccessible at this time.\nConcepts: NO INFORMATION (Admit Source)\tCD40bp Protein (Tumor Necrosis Factor Receptor-Associated Peptides and Proteins)\t175 NEON (Noble Gases)\tBPI Short Form - Pain Other Than Everyday Kinds (Intellectual Product)\tEphrin Type-B Receptor 4, human (Amino Acid, Peptide, or Protein)", + "output": "NO INFORMATION (Admit Source)" + }, + { + "input": "Definition: Laboratory or Test Result described as a semi-quantitative microscopic finding indicating that less than 20 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.\nConcepts: Modular carbohydrate formula component (Food)\tBlasts Less than 20% of Peripheral Blood White Cells (Laboratory or Test Result)\tGrade 2 CD4 Lymphocytes Decreased, CTCAE (Finding)\tLeft Lung, Inferior Lobe, Posterior Basal Segment (Respiratory System Part)\tcomputed tomographic angiography (Diagnostic Procedure)", + "output": "Blasts Less than 20% of Peripheral Blood White Cells (Laboratory or Test Result)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the anterior part of the superior semilunar lobule ( Madigan-1971 ).\nConcepts: Threonine Measurement (Amino acids measurement)\tpositive regulation of calcium ion transport into cytosol (positive regulation of cytosolic calcium ion concentration)\tcrusIa (Posterior superior ansiform lobule of cerebellum)\tstage IVC colon cancer (Stage IV Colon Cancer AJCC v8)\tDrug-Induced Immune Thrombocytopenia (Pathologic Function)", + "output": "crusIa (Posterior superior ansiform lobule of cerebellum)" + }, + { + "input": "Definition: Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v7 described as lip and oral cavity cancer with very advanced local disease. Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery.\nConcepts: (-)-secoisolariciresinol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tLip and Oral Cavity Cancer pT4b TNM Finding v7 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v7)\tFDL (Body Location or Region)\tdeltex homolog 1 (Gene or Genome)\tGrade 2 Intraoperative Neurological Injury, CTCAE (Intraoperative Neurological Injury, CTCAE)", + "output": "Lip and Oral Cavity Cancer pT4b TNM Finding v7 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Disorder of endocardium and heart valve described as condition in which there is a deviation from or interruption of the normal functioning of heart valves.\nConcepts: Dextro-Transposition of the Great Vessels with Ventricular Septal Defect (Disease or Syndrome)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Herpes Simplex 1/2, DNA (Medical Device)\tSimulators, Multiparameter (Simulators)\tvalvular heart diseases (Heart valve disease)\tAdverse Event Involves Cancer (Related to Cancer)", + "output": "valvular heart diseases (Heart valve disease)" + }, + { + "input": "Definition: Qualitative Concept described as information regarding the subject is unknown or inaccessible at this time.\nConcepts: No Answer Provided (Missing Value Reason)\tadenine/cytosine mispair binding (Genetic Function)\tpiRNA dual-strand cluster binding (Genetic Function)\tHealth Risk Assessment (Risk Management)\tOscillator (Manufactured Object)", + "output": "No Answer Provided (Missing Value Reason)" + }, + { + "input": "Definition: Vertebral column described as congenital synostosis between two or more adjacent vertebrae (partial or complete fusion of adjacent vertabral bodies).\nConcepts: Block vertebrae (Vertebral column)\tregulation of transcription from RNA polymerase II promoter in response to stress (regulation of transcription by RNA polymerase II)\tEGFR p.D770 N771insSVQ (Cell or Molecular Dysfunction)\tCONTACT WITH TUBERCULOSIS SOURCE (Personal Attribute)\tmagnetoreception, using mechanical stimulus (sensory perception of mechanical stimulus)", + "output": "Block vertebrae (Vertebral column)" + }, + { + "input": "Definition: Flavobacterium genus described as any bacterial organism that can be assigned to the species Sphingobacterium mizutaii.\nConcepts: Rat Malignant Peripheral Nerve Sheath Tumor (Neoplastic Process)\tIntravenous oxidative medicine administration each 60 minutes (Miscellaneous substance administration)\tSphingobacterium mizutaii (Bacterium)\tIntervening Foreign Body (Finding)\tDepression (excluding suicide and self injury) (Classification)", + "output": "Sphingobacterium mizutaii (Bacterium)" + }, + { + "input": "Definition: Cell described as immune cells that have left the bloodstream and migrated into a tumor.\nConcepts: FLUORESCENCE POLARIZATION IMMUNOASSAY, PHENOBARBITAL (Medical Device)\trubrozerebellare Fasern (Body Part, Organ, or Organ Component)\tUterine Corpus Cancer pT2a TNM Finding v6 (Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6)\tTumor-Infiltrating Immune Cells (Cell)\tRenal Vein (Systemic abdominal vein)", + "output": "Tumor-Infiltrating Immune Cells (Cell)" + }, + { + "input": "Definition: something described as the period of time that the respiratory system findings assessment, done over an interval of time, is intended to begin.\nConcepts: caudal fin development (Organism Function)\tMove (Action)\tRespiratory System Findings Planned Start of Assessment Interval (Temporal Concept)\tCollagen Sealant Plugs, Venous Puncture Site Closure (Medical Device)\tThrombospondin II (Amino Acid, Peptide, or Protein)", + "output": "Respiratory System Findings Planned Start of Assessment Interval (Temporal Concept)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the use of several ANESTHETICS together in small amounts, as opposed to a larger amount of one drug, to induce loss of sensation and loss of consciousness.\nConcepts: Laryngeal Stents (Non-vascular stent)\tCONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIb (Congenital disorder of glycosylation type 2A)\tBalanced Anesthesia (General Anesthesia)\tEarly spermatogenesis maturation arrest (Finding)\tIntralobar sequestration (Bronchopulmonary Sequestration)", + "output": "Balanced Anesthesia (General Anesthesia)" + }, + { + "input": "Definition: Epipodophyllotoxin described as a prodrug of etoposide, a semisynthetic derivative of podophyllotoxin extracted from the mandrake root Podophyllum peltatum, with potential antineoplastic activity. Upon intravenous administration of etoposide toniribate, etoposide is released after enzymatic cleavage of CAP7.1 by specific carboxylesterases (CE) 1 and 2, which are upregulated in certain tumor cell types. Etoposide acts primarily in the G2 and S phases of the cell cycle. This drug binds to and inhibits topoisomerase II, an enzyme elevated in tumor cells. This results in the accumulation of double-strand DNA breaks, the inhibition of DNA replication and transcription and the induction of apoptotic cell death. The tumor-specific activation of etoposide increases its efficacy while lowering its systemic toxicity.\nConcepts: ETOPOSIDE TONIRIBATE (Organic Chemical)\tferrum picricum/iron picrate (Pharmacologic Substance)\tPlant Poisonings (Poisoning)\tSCF-Ctf13 ubiquitin ligase complex location (Cell Component)\tPULM EDEMA (Disorder characterized by edema)", + "output": "ETOPOSIDE TONIRIBATE (Organic Chemical)" + }, + { + "input": "Definition: respiratory burst involved in defense response described as a phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels.\nConcepts: translation initiation complex location (ribonucleoprotein complex location)\tWhiskers (Morphology)\trespiratory burst involved in inflammatory response (respiratory burst involved in defense response)\tpositive regulation of collagen metabolic process (Molecular Function)\tnegative regulation of syncytium formation by plasma membrane fusion (negative regulation of developmental process)", + "output": "respiratory burst involved in inflammatory response (respiratory burst involved in defense response)" + }, + { + "input": "Definition: Gene or Genome described as human HOXB4 wild-type allele is located in the vicinity of 17q21.32 and is approximately 5 kb in length. This allele, which encodes homeobox protein Hox-B4, is involved in anterior-posterior regulation of gene expression during embryonic development.\nConcepts: 6: 116488614-116369687 (Chromosome 6 Physical Location)\tEuclidean Distance (Research Activity)\tugEq/mL/mgEq (Quantitative Concept)\tMitomycins (Organic Chemical)\tHomeobox B4 wt Allele (HOXB4 gene)", + "output": "Homeobox B4 wt Allele (HOXB4 gene)" + }, + { + "input": "Definition: something described as a finding indicating the presence of multiple pouches, usually in the colonic or gastric wall.\nConcepts: Bothered by Low Back Pain (Clinical or Research Assessment Question)\tFetal Growth Retardation, CTCAE (Pregnancy, Puerperium and Perinatal Conditions, CTCAE)\tStage level 2 (General clinical stage for disease AND/OR neoplasm)\tDiverticular disease intestine (Gastrointestinal System Finding)\tparasomnias (Dyssomnias)", + "output": "Diverticular disease intestine (Gastrointestinal System Finding)" + }, + { + "input": "Definition: Remote location existing client without ICD diagnosis described as assessing the health status of an existing nutrition client in a detailed, subsequent, 45-minute, out-of-office meeting to reevaluate and/or develop a treatment plan for nutritional therapy.\nConcepts: organic hydroxy compound catabolic process (organic substance catabolic process)\tViable Cell per Femur (Quantitative Concept)\tNanomole per Day (Unit of Amount of Substance Rate)\tWaiting Rooms (Manufactured Object)\tDetailed subsequent out-of-office visit 45 minutes nutrition intake (Remote location existing client without ICD diagnosis)", + "output": "Detailed subsequent out-of-office visit 45 minutes nutrition intake (Remote location existing client without ICD diagnosis)" + }, + { + "input": "Definition: Immunohistochemistry described as an immunohistochemical diagnostic test utilizing an antibody to detect the phosphorylated form of the AKT protein.\nConcepts: CITRTEXR (Laboratory Procedure)\tpAKT Immunohistochemical Expression Analysis (Immunohistochemistry)\t6: 41588608-41845892 (Chromosome 6 Physical Location)\tCategory for Disposition Event (CDISC SDTM Terminology)\tWu Ling Wan (Pharmacologic Substance)", + "output": "pAKT Immunohistochemical Expression Analysis (Immunohistochemistry)" + }, + { + "input": "Definition: anatomical structure development described as the biological process whose specific outcome is the progression of the hard palate from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. The hard palate is the anterior portion of the palate consisting of bone and mucous membranes.\nConcepts: skin neoplasm carcinoma squamous spindle cell (Squamous cell carcinoma)\tmacrolide binding (organic cyclic compound binding)\tneoplasm - soft tissue blood vessel hemangioendothelioma kaposiform (Intermediate (Locally Aggressive) Blood Vessel Neoplasm)\tphosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine (Molecular Function)\tpalatum durum development (Organ or Tissue Function)", + "output": "palatum durum development (Organ or Tissue Function)" + }, + { + "input": "Definition: Acute lymphoid leukemia in remission described as acute lymphoblastic leukemia in children which is not growing and responds to treatment.\nConcepts: MS (Spectrometers)\tEHIDNA (Microbiology procedure)\tIntestinal Polyposis Syndrome (Neoplastic Process)\tcatabolism by organism of cell wall peptidoglycan in other organism (multi-organism carbohydrate catabolic process)\tPediatric Acute Lymphoid Leukemia in Remission (Neoplastic Process)", + "output": "Pediatric Acute Lymphoid Leukemia in Remission (Neoplastic Process)" + }, + { + "input": "Definition: something described as this gene is involved in neuropeptide signaling.\nConcepts: Grade 1 Mucosal infection (Mucosal Infection, CTCAE)\tHuman papillomavirus - 18 (human papillomavirus)\tUsual Severity Shortness of Breath (Clinical or Research Assessment Question)\tproenkephalin (Neuropeptide Gene)\tEndothelium, Lymphatic (Tissue)", + "output": "proenkephalin (Neuropeptide Gene)" + }, + { + "input": "Definition: something described as a cancer vaccine containing four HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from URLC10 (up-regulated lung cancer 10 or CO16); KOC1 (IGF II mRNA Binding Protein 3); and vascular endothelial growth factor receptors (VEGFRs) 1 and 2. Upon administration, this multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against URL10-, KOC1-, VEGFR1- and VEGFR2-expressing tumor cells, resulting in tumor cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.\nConcepts: dL/m (Miscellaneous Unit)\tPhotography of patient (procedure) [Ambiguous] (Photography of patient)\tHLA-A*2402-restricted URLC10-KOC1-VEGFR1-VEGFR2 multipeptide vaccine (Amino Acid, Peptide, or Protein)\tAggressive Behaviour (Behavioral/psychiatric manifestations)\tTrace Column of Contrast or Air Between Tongue Base and Posterior Pharyngeal Wall During Swallowing (Impairment of Tongue Base Retraction)", + "output": "HLA-A*2402-restricted URLC10-KOC1-VEGFR1-VEGFR2 multipeptide vaccine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Device Labeled for Single Use described as narrow belts designed to keep sanitary (i.e., menstruation) napkins or pads in the appropriate place. These devices typically consist of a narrow, frequently elastic, belt that encircles the woman's pelvis. The belt usually includes a pouch to keep the sanitary napkin or pad and metal and/or plastic hooks in the front and back to hold the sanitary napkins in place. Sanitary menstruation belts are intended for use during the menstruation period.\nConcepts: glycerol-3-phosphate-transporting ATPase (Molecular Function)\tMenstrual Belts (Medical Device)\tEPIC-26 - Hot Flashes (EPIC-26 Questionnaire Question)\tHN3 (Pharmacologic Substance)\tDental Prosthesis Connectors (Medical Device)", + "output": "Menstrual Belts (Medical Device)" + }, + { + "input": "Definition: Organism Function described as any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle.\nConcepts: Hypoplastic/aplastic pubic bones (Aplasia/Hypoplasia involving the pelvis)\tpositive regulation of somitomeric trunk muscle development (regulation of somitomeric trunk muscle development)\tSeverity Score 3 (Clinical or Research Assessment Answer)\t3D mode (Functional Concept)\tResponse to heat (Physiologic Function)", + "output": "positive regulation of somitomeric trunk muscle development (regulation of somitomeric trunk muscle development)" + }, + { + "input": "Definition: Subtotal gastrectomy described as gastrojejunostomy or anastomosis done between the stomach and the jejunum.\nConcepts: DRRI-2 - K: Treated in Overly Critical Way (DRRI-2 Questionnaire Question)\tMiddle Finger (Upper Extremity)\tPrimordial microcephalic dwarfism Crachami type (Hereditary disorder of nervous system)\tBillroth II gastric anastomosis (Anastomosis of stomach)\tTipiracil Hydrochloride Mixture with Trifluridine (Angiogenesis Inhibitors)", + "output": "Billroth II gastric anastomosis (Anastomosis of stomach)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a molecular genetic abnormality indicating the presence of multiple copies of the NTRK3 gene.\nConcepts: TRKC Gene Amplification (Cell or Molecular Dysfunction)\tTransducin (Enzyme)\tNCK2 protein, human (Biologically Active Substance)\tMeshers, Skin Graft (Medical Device)\tdownregulation of nervous system development (Physiologic Function)", + "output": "TRKC Gene Amplification (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as materials or apparatus designed to present information or patterns by means of touch or manipulation. Also, any information or patterns conveyed by such means.\nConcepts: bile acid conjugation (bile acid metabolism)\tKv1.3 Potassium Channel (delayed rectifier potassium channel)\tconn's syndrome (Hyperaldosteronism)\tTactual Displays (Display - arrangement)\tIncreased thiamine diet (Thiamine modified diet)", + "output": "Tactual Displays (Display - arrangement)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether cancer or treatment has reduced an individual's satisfaction with their present financial situation.\nConcepts: Hypocellular Myelodysplastic Syndrome (MYELODYSPLASTIC SYNDROME)\tPathologic Stage IVA Esophageal Adenocarcinoma AJCC v8 (Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8)\tHEALTH-RELATED BEHAVIORS DOMAIN (Classification)\tMy cancer or treatment has reduced my satisfaction with my present financial situation (Clinical or Research Assessment Question)\tSp2 Transcription Factor (Amino Acid, Peptide, or Protein)", + "output": "My cancer or treatment has reduced my satisfaction with my present financial situation (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: ANSD Version 1.0 Questionnaire Question described as asthma Nighttime Symptom Diary V1.0 (ANSD Version 1.0) Please rate your shortness of breath at its worst since you went to bed last night.\nConcepts: ExperimentalFactor.type (Intellectual Product)\tFamilial dementia Danish type (Disease or Syndrome)\tANSD Version 1.0 - Rate Shortness of Breath at Worst (Intellectual Product)\tDemineralized Bone Tissue (Bone Matrix)\tMIR92A2 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "ANSD Version 1.0 - Rate Shortness of Breath at Worst (Intellectual Product)" + }, + { + "input": "Definition: phosphoric monoester hydrolase activity described as catalysis of the reaction: 2,3-diphosphoglycerate + H2O = phosphoglycerate + phosphate.\nConcepts: vestibulospinal pathway (Descending spinal cord tract)\t2,3-bisphosphoglycerate phosphatase activity (phosphoric monoester hydrolase activity)\tGrade 3 Hepatitis viral (Hepatitis Viral, CTCAE 5)\tEarly Infantile Epileptic Encephalopathy Gene Panel Reagents (Medical Device)\t2H-1-benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-, (3S)- (Organic Chemical)", + "output": "2,3-bisphosphoglycerate phosphatase activity (phosphoric monoester hydrolase activity)" + }, + { + "input": "Definition: Information Resources described as ensembl is a joint project between EMBL-EBI and the Sanger Institute to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. Ensembl is primarily funded by the Wellcome Trust. The Ensembl Genome Browser can be accessed through www.ensembl.org.\nConcepts: Clostridium difficile tcdC DNA Measurement (Laboratory Procedure)\tEar Canal Irrigators (Medical irrigating device)\tEnsembl (Information Resources)\tIVD Test Reagent/Kits, Hematology, Blood Cell Count, Automated Test, Reticulocyte (IVD Test Reagent/Kits, Hematology, Blood Cell Count, Automated Test)\tNon-Surgical (Functional Concept)", + "output": "Ensembl (Information Resources)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subclass of clathrin assembly proteins that occur as monomers.\nConcepts: CDISC Questionnaire WHODAS 2.0 36-item Version Proxy-administered Test Code Terminology (CDISC Questionnaire Terminology)\tmediastinal node (Lymph Node by Anatomic Site)\tShields, Radiotherapy Block (Medical Device)\tClathrin Assembly Proteins, Monomeric (Biologically Active Substance)\tBruceanol C (Pharmacologic Substance)", + "output": "Clathrin Assembly Proteins, Monomeric (Biologically Active Substance)" + }, + { + "input": "Definition: Device electrical issues described as problem associated with the inability of the device to generate a therapeutic simulated heart beat via electrical impulses.\nConcepts: ALCOHOLISM (Drug-related disorder)\tTEST, THROMBIN TIME (Medical Device)\tTelomerase-specific Type 5 Adenovirus OBP-301 (Oncolytic Viruses)\tEndometrial Hyperplasias, Complex (Benign endometrial hyperplasia)\tPacing Problem (Finding)", + "output": "Pacing Problem (Finding)" + }, + { + "input": "Definition: Complement 2 described as the COOH-terminal fragment of COMPLEMENT 2, released by the action of activated COMPLEMENT C1S. It is a SERINE PROTEASE. C2a combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).\nConcepts: Allergy to venom (Allergic conditions NEC)\tladanein 6-O-methyltransferase activity (Molecular Function)\tTransdisciplinary Tobacco Use Research Center (Component of the Division of Cancer Control and Population Sciences)\tComplement 2a (Complement 2)\tAntepartum state, fetus (Growth and Development function)", + "output": "Complement 2a (Complement 2)" + }, + { + "input": "Definition: something described as an individual whose profession is to apply engineering principles to understand, modify, or control biologic systems, as well as design and manufacture products that can monitor physiologic functions and assist in the diagnosis and treatment of patients.\nConcepts: stage IIIB intrahepatic bile duct cancer (stage III intrahepatic bile duct cancer)\tDisproportionate Share Reimbursements (Governmental or Regulatory Activity)\tTransdermal solution (Solution Dosage Form)\tTechnician, Other - Biomedical Engineering (Professional or Occupational Group)\tFractional Phosphorus Excretion (Kidney Function Tests)", + "output": "Technician, Other - Biomedical Engineering (Professional or Occupational Group)" + }, + { + "input": "Definition: Stability Duration described as the period of time during which the biologic product is considered stable.\nConcepts: Pesticide Toxicology (Toxicology)\tVasa Praevias (Obstetric Labor Complications)\tBiologic.stabilityDuration (Stability Duration)\tnegative regulation of ecdysone receptor-mediated signaling pathway (negative regulation of cellular response to alcohol)\toculogyric crisis was observed (Central Nervous System)", + "output": "Biologic.stabilityDuration (Stability Duration)" + }, + { + "input": "Definition: extracellular non-membrane-bounded organelle described as a complex, symbiont-induced host-derived organelle that is comprised of multiple protein and lipid domains.\nConcepts: Fanconi Anemia Core Complex-Associated Protein 24 (DNA repair protein)\tCrescentic glomerulonephritis (Kidney)\tTVN (Cell Component)\tPetroselinum sativum (Organic Chemical)\tRecurrent Dedifferentiated Chordoma (Dedifferentiated chordoma)", + "output": "TVN (Cell Component)" + }, + { + "input": "Definition: something described as this gene plays a role in the reorganization of the actin cytoskeleton.\nConcepts: FLJ39957 (Gene or Genome)\tSaturated fatty acid, NOS (Dietary Fatty Acid)\tI-THORAC (Anatomy Qualifier)\tBlastemal Cell (Embryonic Cell)\tHyperplasia of endometrium (Abnormality of the endometrium)", + "output": "FLJ39957 (Gene or Genome)" + }, + { + "input": "Definition: Regimen Used to Treat Malignant Testicular Neoplasm described as a regimen consisting of cisplatin, vinblastine and bleomycin used for the treatment of advanced-stage testicular cancer; also used as treatment for poor-prognosis metastatic gestational trophoblastic tumors.\nConcepts: Platinol/Vinblastine/Bleomycin (Therapeutic or Preventive Procedure)\tBlasts 5-25 Percent of Bone Marrow Nucleated Cells (Finding)\tSF 1126 (Amino Acid, Peptide, or Protein)\tB16alphaGal melanoma vaccine (Melanoma vaccine)\tPharmacy Distribution Center (Manufactured Object)", + "output": "Platinol/Vinblastine/Bleomycin (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Fixed orthodontic appliance component described as an orthodontic appliance and accessories is a device intended for use in orthodontic treatment. The device is affixed to a tooth so that pressure can be exerted on the teeth. This device includes the preformed orthodontic band, orthodontic band material, orthodontic elastic band, orthodontic metal bracket, orthodontic wire clamp, preformed orthodontic space maintainer, orthodontic expansion screw retainer, orthodontic spring, orthodontic tube, and orthodontic wire.\nConcepts: ARG-1 Peptide Vaccine (Cancer Vaccines)\tBreast Measurement (Personal Attribute)\tBrilacidin Oral Rinse (Clinical Drug)\tOrthodontic band, elastic (Orthodontic band)\tsiderophore-dependent iron import into cell (Cell Function)", + "output": "Orthodontic band, elastic (Orthodontic band)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as molecules found on the surface of some, but not all, B-lymphocytes, T-lymphocytes, and macrophages, which recognize and combine with the Fc (crystallizable) portion of immunoglobulin molecules.\nConcepts: Mongolic Language (Language)\tdiet free gluten (Dietary and nutritional therapies)\tMaximum ST Segment Depression by ECG Finding (ST segment depression)\tProtein Trafficking (Cell Function)\tReceptors, Fc (Receptors, Immunologic)", + "output": "Receptors, Fc (Receptors, Immunologic)" + }, + { + "input": "Definition: nucleotide binding described as interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate.\nConcepts: UPD2305A (MDS-UPDRS Questionnaire Question)\tpyrimidine nucleotide binding (Molecular Function)\tVena ovarica sinistra (Structure of left ovary)\tBladder Papillary Clear Cell Adenocarcinoma (clear cell adenocarcinoma of bladder)\tPorphyria, Erythrohepatic (Porphyrias, Hepatic)", + "output": "pyrimidine nucleotide binding (Molecular Function)" + }, + { + "input": "Definition: Congenital Abnormality described as the presence of more than the normal number of carpal bones.\nConcepts: Extra wrist bones (Other congenital malformations of upper limb(s), including shoulder girdle)\tTubular Hypomagnesemia-Hypokalemia with Hypocalcuria (Familial hypokalemic and hypomagnesemic tubulopathy)\tInternational Breast Cancer Study Group (Professional Organization or Group)\tMultidose container (Containers)\tmediator complex subunit 23 (Sp1 Activation Cofactor Gene)", + "output": "Extra wrist bones (Other congenital malformations of upper limb(s), including shoulder girdle)" + }, + { + "input": "Definition: Pharmacologic Substance described as describes a drug or effect that works against tuberculosis (a contagious bacterial infection that usually affects the lungs).\nConcepts: Tuberculostatic Agent (Microbicides)\tWord Recall: Word [6] (Intellectual Product)\tHaemangiopericytic meningioma [obs] (Vascular Neoplasms)\tupregulation of cytoplasmic translational elongation (Cell Function)\tBPRS0115 (BPRS 1988 Version Clinical Classification Question)", + "output": "Tuberculostatic Agent (Microbicides)" + }, + { + "input": "Definition: Korean Standard Classification of Disease Version 5 described as acute inflammation of the kidney affecting the interstitium of the kidneys surrounding the tubules.\nConcepts: CRANIOSTENOSIS, SAGITTAL, WITH CONGENITAL HEART DISEASE, MENTAL DEFICIENCY, AND MANDIBULAR ANKYLOSIS (Congenital heart disease)\tNasal Cavity and Ethmoid Sinus Cancer TNM Finding v7 (Finding)\tVulvar Carcinoma pT3 TNM Finding v8 (Finding)\tATIN (Tubulo-interstitial nephritis, not specified as acute or chronic)\tHereditary Nonpolyposis Colon Cancer (Malignant neoplasm of large intestine)", + "output": "ATIN (Tubulo-interstitial nephritis, not specified as acute or chronic)" + }, + { + "input": "Definition: Laboratory or Test Result described as indicates that expression of a fusion containing sequences from MYD88 has been detected in a sample.\nConcepts: I talked less than usual (Intellectual Product)\tcardiac ventricle morphogenesis (cardiac chamber morphogenesis)\tTSCYC - Being Tense (Intellectual Product)\tMYD88 Fusion Positive (Rearrangement Detected)\tCytochrome P-450 CYP3A Inhibitors (Pharmacologic Substance)", + "output": "MYD88 Fusion Positive (Rearrangement Detected)" + }, + { + "input": "Definition: Hypertrophic disorder of skin, unspecified described as an autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.\nConcepts: C-SSRS Baseline/Screening Version Phase 1 Study - Active Suicidal Ideation with Specific Plan and Intent (Intellectual Product)\tBone Marrow Specimen (Bone sample)\tdebiopharm 1347 (FGFR Inhibitor)\tPsoriasis, unspecified (Disease of Skin and Appendages)\tPostsurgical Stage II (Hepatoblastoma Stage)", + "output": "Psoriasis, unspecified (Disease of Skin and Appendages)" + }, + { + "input": "Definition: Water consumption described as the approximate intake in one day of water.\nConcepts: Timely and Efficient Chewing and Mashing (Impairment of Bolus Preparation or Mastication)\tEstimated oral intake of water in 24 hours (Quantitative Concept)\tprotozoal disease coccidiosis enteric (protozoal; infection, intestinal)\tGenus Oidiodendron (Fungus)\tOrganoid Thymoma (Neoplastic Process)", + "output": "Estimated oral intake of water in 24 hours (Quantitative Concept)" + }, + { + "input": "Definition: something described as a question about whether an individual's doctor looks out for the individual's interests in dealing with their health insurer.\nConcepts: LMP (Finding of measures of menstruation)\tBolwig's organ morphogenesis (Organ or Tissue Function)\tdown regulation of thiamine diphosphate biosynthetic process (negative regulation of phosphate metabolic process)\tsyringe injection insulin (Medical Device)\tThis doctor looks out for my interests in dealing with my health insurance (Intellectual Product)", + "output": "This doctor looks out for my interests in dealing with my health insurance (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X.\nConcepts: Lung adenocarcinoma recurrent (Non-small cell neoplasms malignant of the respiratory tract cell type specified)\tStereoscopic Presentation (Stimulus Presentation Methods)\tepithelial (Qualitative Concept)\tprecorrin-6A synthase (deacetylating) activity (methyltransferase activity)\tregulation of cellular response to basic pH (regulation of cellular process)", + "output": "precorrin-6A synthase (deacetylating) activity (methyltransferase activity)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of interleukin-32 secretion.\nConcepts: regulation of interleukin-32 secretion (Cell Function)\tBRINCIDOFOVIR (Pharmacologic Substance)\tOsteosclerotic Lesion (Finding)\tregulation of Ral protein signal transduction (Cell Function)\tStructure of anterior middle regional part of peripheral zone of right half prostate (Peripheral zone of prostate)", + "output": "regulation of interleukin-32 secretion (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as computer software and other technology designed to enable communication and foster productivity both within and among groups of people working together on a task.\nConcepts: cell dedifferentiation (Cell Physiological Processes)\tAdenylate Cyclase-Stimulating G Alpha Protein Gln227Glu (Cell or Molecular Dysfunction)\tGroupware (Computer Applications)\tAlphaglobulin (Laboratory Procedure)\t(mL/h)/ug (Unit of Dose Calculation)", + "output": "Groupware (Computer Applications)" + }, + { + "input": "Definition: regulation of cellular localization described as any process that modulates the establishment or extent of a change in membrane potential in the polarizing direction towards the resting potential in a cardiomyocyte.\nConcepts: IVD Test Reagent/Kits, Clinical Chemistry, Electrolyte, Calcium (IVD Test Reagent/Kits, Clinical Chemistry, Electrolyte)\tregulation of cardiac muscle cell membrane repolarization (Cell Function)\ts^-1(%O2)^-1 (Miscellaneous Unit)\tHydrochloride, Duloxetine (Norepinephrine re-uptake inhibitor)\tEpithelial cell of prostatic acinus (Cell)", + "output": "regulation of cardiac muscle cell membrane repolarization (Cell Function)" + }, + { + "input": "Definition: Elevated Test Result described as a laboratory test result which indicates an increased level of alkaline phosphatase in a biological specimen.\nConcepts: CALICIVIRIDAE (unclassified ssRNA positive-strand viruses)\tBlood Alkaline Phosphatase Increased (Abnormal Blood Chemistry and Hematology Test Result)\tIncrease or decrease in thiamin content of the diet. Treatment for prevention of beriberi. (Source: Dietary Reference Intakes: Vitamins; USDA Food and Nutrition Center). (Therapeutic or Preventive Procedure)\tChlamydomona (Volvocida)\tion homeostasis (Physiologic Function)", + "output": "Blood Alkaline Phosphatase Increased (Abnormal Blood Chemistry and Hematology Test Result)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cancer cell vaccine consisting of autologous dendritic cells (DCs) loaded with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion protein with the full-length lysosome-associated membrane protein (flLAMP), with potential immunostimulatory and antineoplastic activities. Upon vaccination, the autologous CMV-pp65-flLAMP mRNA loaded DC vaccine exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of flLAMP may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types.\nConcepts: Have Lost Interest in Sex (Findings-Based Question)\tPreparation, Tooth (Dentistry)\tAutologous flLAMP-pp65-DCs (Dendritic Cell Vaccine)\tEpidermoid Carcinoma of Salivary Gland (Neoplastic Process)\tTongue (Finding)", + "output": "Autologous flLAMP-pp65-DCs (Dendritic Cell Vaccine)" + }, + { + "input": "Definition: Male Urethral Malignant Neoplasm described as a primary or metastatic malignant neoplasm that affects the prostatic urethra.\nConcepts: Screw Head Device (Head - Component of Device)\tProstatic Urethral Malignant Neoplasm (Neoplastic Process)\tWT1 235-243 peptide vaccine (Immunologic Factor)\tFibulin 1-related developmental delay, central nervous system anomaly, syndactyly syndrome (Intellectual Disability)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, EYA1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)", + "output": "Prostatic Urethral Malignant Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Occupation or Discipline described as an interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and cybernetics.\nConcepts: Staphylococcus schleiferi (Bacterium)\tOptic Cup to Disc Ratio (Optic disc finding)\tmuscles pectoral (Muscle)\tInformation and Communication (Information Sciences)\tHealth, Community (Biomedical Occupation or Discipline)", + "output": "Information and Communication (Information Sciences)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures of the foregut are generated and organized, during the post-embryonic phase.\nConcepts: QIDSR118 (Intellectual Product)\tPremalignant disorders, general conditions and other site specific disorders (Classification)\tSurgery Domain (Domain)\tpost-embryonic foregut morphogenesis (post-embryonic animal morphogenesis)\tMissing scaphoid bone (Carpal bone aplasia)", + "output": "post-embryonic foregut morphogenesis (post-embryonic animal morphogenesis)" + }, + { + "input": "Definition: Nucleoside and nucleotide reverse transcriptase inhibitors described as a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, lamivudine is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1471\" active clinical trials using this agent.\nConcepts: Increased vitamin A diet (Therapeutic or Preventive Procedure)\t(-)-2'-Deoxy-3'-thiacytidine (Reverse Transcriptase Inhibitors)\tCYCLIN-DEPENDENT KINASE 16 (Cyclin-Dependent Kinase Gene)\tLiver Cancer pTX TNM Finding v7 (Liver Cancer Pathologic Primary Tumor TNM Finding v7)\tmethylamine:amicyanin oxidoreductase (deaminating) activity (oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor)", + "output": "(-)-2'-Deoxy-3'-thiacytidine (Reverse Transcriptase Inhibitors)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cannabigerolate + O2 <=> cannabidiolate + hydrogen peroxide.\nConcepts: Did you take any medication (except study drug) for NAUSEA in the past 24 hours (Findings-Based Question)\tcannabidiolate synthase activity (Molecular Function)\tCardiac Mapping/Ablation Image-Guided Stereotactic System Software (Software, Stereotactic System)\tDEATH CAUSE (Domain)\tLIR-D1 (Regulatory Protein)", + "output": "cannabidiolate synthase activity (Molecular Function)" + }, + { + "input": "Definition: Activity described as a sterilization process that uses chlorine dioxide at ambient temperatures to kill microorganisms. This process can be used in large spaces.\nConcepts: Chlorine Dioxide (Sterilization for infection control)\tInsulin Antibody (LABORATORY IMMUNOLOGIC PROCEDURES)\tCytotoxic T lymphocyte (T-Lymphocyte Subsets)\tAdvanced Endometrial Carcinoma (Advanced Malignant Female Reproductive System Neoplasm)\tLow frequency (Heart Sound Categorized by Pitch)", + "output": "Chlorine Dioxide (Sterilization for infection control)" + }, + { + "input": "Definition: Package Type described as a container designed to give out the contents in convenient or/and prescribed amounts.\nConcepts: TUT3 protein, human (Polynucleotide Adenylyltransferase)\tCatheter-Related Infection (Complication of catheter)\tMicroRNA 197 wt Allele (MIR197 gene)\tdispensers (Devices)\tPedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Hard to Breathe (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question)", + "output": "dispensers (Devices)" + }, + { + "input": "Definition: Pesticides described as the organophosphorus agent dichlorvos.\nConcepts: Alpha tumour necrosis factor (Laboratory Procedure)\tpulmonary kaposi's sarcoma (Sarcoma of lung)\tAble to Adapt When Changes Occur (Clinical or Research Assessment Question)\tPhosphoric acid 2,2 dichloroethenyl dimethyl ester (Pesticides)\tCup/disc ratio (Examination of physiologic cup of optic disc)", + "output": "Phosphoric acid 2,2 dichloroethenyl dimethyl ester (Pesticides)" + }, + { + "input": "Definition: something described as a light cell found in taste buds, characterized by afferent synaptic specializations to intragemminal nerve endings including increased density of the plasma membrane along the nerve and aggregations of synaptic vesicles, and by the presence of cored vesicles of 80-150 nm in diameter. The core is dense and the cell is immunoreactive for 5-hydroxytryptamine, neural cell adhesion molecule, and PGP 9.5.\nConcepts: INO-1001 (Poly(ADP-ribose) Polymerase Inhibitors)\tDIAGNOSIS (Trial Indication Type)\tAnal Carcinoma pTX TNM Finding v8 (Anal Cancer Pathologic Primary Tumor TNM Finding v8)\tType III Epithelial Receptor Cell (Taste bud cell)\tXmAb 23104 (Amino Acid, Peptide, or Protein)", + "output": "Type III Epithelial Receptor Cell (Taste bud cell)" + }, + { + "input": "Definition: Cell Function described as the process in which copies of the mitochondrial genome are distributed into daughter mitochondria upon mitochondrial fission.\nConcepts: Basophil to Leukocyte Ratio (Blood Cell Count Ratio Measurement)\tIntrahepatic Bile Duct Cancer pTis TNM Finding v7 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7)\tCycled-Simple (Intellectual Product)\tCOPD ASSESSMENT TEST (Clinical or Research Assessment Questionnaire)\tmitochondrial DNA inheritance (Cell Function)", + "output": "mitochondrial DNA inheritance (Cell Function)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as an individual who befriends and facilitates the development of a less experienced individual, especially within a profession, business, trade, or academic environment.\nConcepts: Joule per Kilogram (Quantitative Concept)\tkilling of inflammatory cells (Cell Function)\tBreast Cancer cN3b TNM Finding v8 (Finding)\tmentors (Population Group)\tPrimary Hepatic Neuroendocrine Carcinoma (Primary Malignant Liver Neoplasm)", + "output": "mentors (Population Group)" + }, + { + "input": "Definition: something described as mitosporic fungal species which causes coccidiodomycosis.\nConcepts: SODD/TNFR1 Signaling Pathway (Signal Transduction Pathways)\tMalbranchea of Coccidi immitis (Mitosporic Ascomycota)\tEnterococcus casseliflavus (ex Vaughan et al. 1979) Collins et al. 1984 (Enterococcus)\tSubj Other (Intellectual Product)\tion gated channel activity (gated channel activity)", + "output": "Malbranchea of Coccidi immitis (Mitosporic Ascomycota)" + }, + { + "input": "Definition: Finding described as impaired response of CD8 T cells to pathogens. CD8 T cells direct the killing of a target cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.\nConcepts: protozoal vaccine (Immunologic Factor)\tinhibition of flagellin-based flagellar cell motility (negative regulation of cell motility)\tRoot Identifier (Unique Identifier)\tImpaired pathogen-specific CD8 cytoxicity (Finding)\tGAIA Level 1 Vasa Previa (GAIA Antenatal Bleeding Level of Diagnostic Certainty)", + "output": "Impaired pathogen-specific CD8 cytoxicity (Finding)" + }, + { + "input": "Definition: something described as process of grieving and mourning; associated with a deep sense of loss and sadness.\nConcepts: Tonsil Neoplasms (Neoplasm of upper respiratory tract)\tbereavement (Social/Family Issues)\tneurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium levels (Molecular Function)\tGerota Fascia (Perirenal tissue)\tactivation of actin filament-based movement (positive regulation of cellular component movement)", + "output": "bereavement (Social/Family Issues)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.\nConcepts: acetylcholine transmembrane transporter activity (acetate ester transmembrane transporter activity)\tHistiocytosis, NOS (Reticuloendotheliosis, X-linked)\td.ug/ml/(kg/m2) (Measurement Unit Description)\tAmpulla of Vater Pancreatobiliary Type Adenocarcinoma (Neoplastic Process)\tADAPTOR, SHUNT (Non-Active Implantable Devices)", + "output": "acetylcholine transmembrane transporter activity (acetate ester transmembrane transporter activity)" + }, + { + "input": "Definition: something described as an increased concentration of insulin in the blood in the fasting state, i.e., not as the response to food intake.\nConcepts: education science (Educational Curriculum)\tSDTM-SKINTYP (CDISC SDTM Terminology)\tCalifornia virus encephalitis (Disease due to California serogroup virus)\tNuclear Protein (Proteins)\tHyperinsulinemia, fasting (Finding)", + "output": "Hyperinsulinemia, fasting (Finding)" + }, + { + "input": "Definition: Biologically Active Substance described as a protein encoded by the PNOC gene.\nConcepts: agenesis (Aplasia, NOS)\tPNOC Gene Product (Biologically Active Substance)\tFryer Oil Filtration Machines (Diagnostic, Therapeutic, and Research Equipment)\tRecombinant Tyrosinase-Related Protein-1 (Tumor Antigens)\tPyrolaceae (Magnoliopsida)", + "output": "PNOC Gene Product (Biologically Active Substance)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as this term describes an experiment in which probes representing genes that one wants to study are affixed to a substrate (e.g., a glass slide) and then exposed to target molecules (sometimes referred to as the sample). The level of hybridization between a specific probe and a target (typically indicated through fluorescence and measured through image analysis) indicates the level of the gene corresponding to that probe in a test solution.\nConcepts: FAC015-My Mouth Is Dry (Intellectual Product)\tmicroarray analysis DNA (Molecular Biology Research Technique)\tParaneoplastic Syndromes (Syndrome)\t4-hydroxymandelate synthase activity (Molecular Function)\tPerformed Substance Administration End Relative To Reference Code (End Relative To Reference Code)", + "output": "microarray analysis DNA (Molecular Biology Research Technique)" + }, + { + "input": "Definition: something described as investigations into the relationship between immune function and cancer. Immunodeficient individuals are less able to mount an attack on cancerous cells.\nConcepts: Galectin-3 Antibody (Antibodies)\tMumps virus (Paramyxovirus, NOS)\txylan 1,4-beta-xylosidase activity (Molecular Function)\tSmall cell carcinoma of the cervix (Neuroendocrine cervical carcinoma)\tImmunodeficiency and Cancer (Cancer Etiology)", + "output": "Immunodeficiency and Cancer (Cancer Etiology)" + }, + { + "input": "Definition: Cell described as a population of cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (ADV) and BK virus (BKV), with potential antiviral and protective activities. T cells derived from peripheral blood mononuclear cells (PBMCs) are exposed to and activated by dendritic cells (DCs) that are loaded with specific peptides from CMV, EBV, ADV and BKV. Upon infusion of the CMV/EBV/ADV/BKV-specific CTLs, these lymphocytes target and cause lysis of CMV-, EBV-, ADV- and/or BKV-infected cells and may prevent infection and complications from CMV-, EBV-, ADV- and BKV-driven viral diseases. Opportunistic infections caused by these viruses are often seen in immunosuppressed patients.\nConcepts: Burden, Care Giving (Thesaurus of Psychological Index Terms)\tCMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes (Antineoplastic Immune Cell)\tBoozer (problem AOD user)\tNitrofurantoin, Monohydrate (nitrofurantoin)\tFunction (Functional Concept)", + "output": "CMV/EBV/ADV/BKV-specific Cytotoxic T Lymphocytes (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as duplication of the spinal cord.\nConcepts: Diplomyelia (Spinal cord lesion)\tPhysical Quantity to Physical Quantity Time Ratio Data Type (Intellectual Product)\tsitus inversus (Abnormality of abdominal situs)\tCommunicable diseases (Inflammatory disorder)\tFluvoxamine measurement (Chemical procedure)", + "output": "Diplomyelia (Spinal cord lesion)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Holdemania filiformis.\nConcepts: recto (Intestines)\tAcid phos (Laboratory Procedure)\tHoldemania filiformis Willems et al. 1997 (Bacterium)\tNitrogen Mustard N-oxide Hydrochloride (Nitrogen Mustard Antineoplastic Compounds)\tBone Marrow Failure Syndromes, Congenital (Neonatal disorder)", + "output": "Holdemania filiformis Willems et al. 1997 (Bacterium)" + }, + { + "input": "Definition: something described as a traumatic break in two or more places in one rib, or a traumatic break in more than one rib, that does not involve a break in the adjacent skin.\nConcepts: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma cM1 TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Clinical Distant Metastasis TNM Finding v8)\tRIB FRACTURE MULTIPLE CLOSED (Fracture of multiple ribs)\tgestational (Temporal Concept)\tCYP2C8, c.556C>T (Gene or Genome)\tADP-D-ribosyl-dinitrogen reductase ADP-ribosylhydrolase activity (Molecular Function)", + "output": "RIB FRACTURE MULTIPLE CLOSED (Fracture of multiple ribs)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIIA includes: T4, N0-2, M0, B0. T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells).\nConcepts: establishment of protein localisation in postsynaptic membrane (protein localization to postsynaptic membrane)\tDefinedCriterionGroupCompositionRelationship.pauseQuantityRange (Quantitative Concept)\tribonucleoside-diphosphate reductase inhibitor activity (enzyme inhibitor activity)\tNEUTMY (Complete Blood Count)\tStage IIIA Mycosis Fungoides and S\u00e9zary Syndrome AJCC v7 (Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7)", + "output": "Stage IIIA Mycosis Fungoides and S\u00e9zary Syndrome AJCC v7 (Stage III Mycosis Fungoides and Sezary Syndrome AJCC v7)" + }, + { + "input": "Definition: something described as establishment of the adult pattern of pigmentation in the chitin-containing cuticle of an organism. An example of this is the adult cuticle pigmentation process in Drosophila melanogaster.\nConcepts: Portion of sputum (Bodily secretions)\tadult cuticle pigmentation (cuticle pigmentation)\tADL01-Use Common Used Appliances (ADCS-ADL Questionnaire Question)\ttryptophan breakdown to kynurenine (tryptophan catabolic process)\tlysophosphatidylcholine flippase activity (glycerophospholipid flippase activity)", + "output": "adult cuticle pigmentation (cuticle pigmentation)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Ganitumab binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a tyrosine kinase and a member of the insulin receptor family. IGF-1R activation stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C71531\" active clinical trials using this agent.\nConcepts: Lack of T cell function (Finding)\tdefence response to Gram-negative bacterium (Pathologic Function)\tExposure (Domain)\tCSS04-Number of Interrupt Attempts-Life (Intellectual Product)\tGANITUMAB (Pharmacologic Substance)", + "output": "GANITUMAB (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as an adenoma that arises from the intrahepatic bile ducts and it is characterized by the presence of microcystic changes.\nConcepts: septic; shock (Circulatory collapse and shock)\tPCM1 (Amino Acid, Peptide, or Protein)\tSclerosing Rhabdomyosarcoma (cellular diagnosis, childhood rhabdomyosarcoma)\tIntrahepatic Bile Duct Microcystic Adenoma (Neoplastic Process)\tRAMP2 Gene (Trafficking Protein Gene)", + "output": "Intrahepatic Bile Duct Microcystic Adenoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.\nConcepts: Celosomy (Congenital Abnormality)\tendogenous peptide antigen processing and presentation via MHC class Ib via ER pathway (antigen processing and presentation of endogenous peptide antigen via MHC class Ib)\tProbes, Molecular (Indicators and Reagents)\tIBP5 (Gene or Genome)\tacetyl-CoA:oxaloacetate acetyltransferase (Molecular Function)", + "output": "Celosomy (Congenital Abnormality)" + }, + { + "input": "Definition: Molecular Function described as covalent attachment of a glycosyl residue to a lipid molecule.\nConcepts: Spiranthes autumnalis / lady's tresses (Organic Chemical)\tarch (Foot)\tregulation of histone modification (regulation of chromatin organization)\tC-SSRS Children's Baseline Questionnaire Question (Clinical or Research Assessment Question)\tlipid glycosylation (lipid modification)", + "output": "lipid glycosylation (lipid modification)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP.\nConcepts: UMP-CMP kinase activity (Molecular Function)\tAssistance Reading Answers (Finding)\tinhibition of ATP phosphohydrolase (Molecular Function)\tStructure of retina of left eye (Tunica interna of eyeball)\tEPICONDYLITIS (Enthesopathy of elbow region)", + "output": "UMP-CMP kinase activity (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as family of proteins which bind phospholipids in the presence of calcium, believed to mediate intracellular calcium's role in membrane fusion and related events such as exocytosis; lipocortin and endonexin may also function extracellularly as inhibitors of phospholipase and blood coagulation.\nConcepts: Brachytherapy Microspheres (Microspheres, Embolization)\tannexin (Amino Acid, Peptide, or Protein)\tribostamycin metabolism (Sulfur Metabolism Pathway)\tAbnormality of movement (Brain and Nerves)\tHEALTH RESOURCES SERV ADMIN (United States Public Health Service)", + "output": "annexin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species.\nConcepts: D.O. (Professional Doctorate)\tmicrotubule plus-end directed mitotic chromosome migration (Cell Function)\tPosterior Urethral Valve (Other congenital malformations of urinary system)\tbeta-galactosidase complex (catalytic complex location)\tcAMP-dependent protein kinase inhibitor activity (Molecular Function)", + "output": "beta-galactosidase complex (catalytic complex location)" + }, + { + "input": "Definition: Health Care Activity described as the process by which semen is kept viable outside of the organism from which it was derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).\nConcepts: YERSINIA ROHDEI (Bacterium)\tINSTRUMENT, SURGICAL, DISPOSABLE (Medical Device)\tCDP-choline:1-alkenyl-2-acylglycerol cholinephosphotransferase activity (Molecular Function)\tLeucine Zipper Like Transcription Regulator 1 Gene (Transcription factor genes)\tSemen Preservation (Health Care Activity)", + "output": "Semen Preservation (Health Care Activity)" + }, + { + "input": "Definition: raised broad flat-surfaced plaque described as a solid, raised, plateau-like (flat-topped) lesion greater than 1 cm in diameter and that has a yellow color. []\nConcepts: SIQR0105 (SIQR Questionnaire Question)\tBC-819 plasmid/polyethylenimine complex (Pharmacologic Substance)\tGeneral Transcription Factor IIIC2 Beta 110kDa (Transcription Factors, General)\tskin plaque: yellow [as symptom] (raised broad flat-surfaced plaque)\tPEComa of the Kidney (Neoplastic Process)", + "output": "skin plaque: yellow [as symptom] (raised broad flat-surfaced plaque)" + }, + { + "input": "Definition: Combined Dosage Form described as combination package consisting of a cream and a vaginal tablet.\nConcepts: Substance-induced sleep disorder (Disease or Syndrome)\tHoover Technique (Osteopathic manipulation)\tIL-8 production (cytokine production)\tTeaching: Infant Stimulation 5-8 Months (Educational Activity)\tCream plus Vaginal Tablet Dosage Form (Combined Dosage Form)", + "output": "Cream plus Vaginal Tablet Dosage Form (Combined Dosage Form)" + }, + { + "input": "Definition: Congenital absence of vas deferens described as an autosomal recessive disorder that is associated with mutation(s) in the CFTR gene, encoding cystic fibrosis transmembrane conductance regulator. Mutation(s) in the same gene are associated with cystic fibrosis.\nConcepts: down-regulation of ATP:ADP antiporter activity (negative regulation of response to drug)\tCongenital Bilateral Absence of Vas Deferens (Rare Non-Neoplastic Disorder)\tv-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Gene Exon 17 Mutation (Cell or Molecular Dysfunction)\tzm (Quantitative Concept)\tGrade 1 Spinal fracture (Finding)", + "output": "Congenital Bilateral Absence of Vas Deferens (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a composite substructure of pontine tegmentum at its junction with the midbrain. It includes the superior medullary velum, the superior cerebellar peduncle and the decussation of the trochlear nerve ( Carpenter-1983 ).\nConcepts: CD178 (Gene or Genome)\tIsthmus rhombencephali (Embryonic Structures)\tendomembrane system organization (cellular component organization)\tWombs (Structure of fetal genitourinary system)\tregulation of interleukin-25 secretion (regulation of interleukin-25 production)", + "output": "Isthmus rhombencephali (Embryonic Structures)" + }, + { + "input": "Definition: Finding described as an electrocardiographic finding of sinus bradycardia with a heart rate below a threshold of clinical concern. Note that different thresholds (for rate and/or duration) may apply to different patient populations.\nConcepts: MARKED SINUS BRADYCARDIA (Finding)\tOral Mucosal Deterging and Dental Prophylaxis (Health Care Activity)\tintertrigo (Other and unspecified dermatitis)\tSETTER, BAND, ORTHODONTIC (Medical Device)\t4,5-9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase activity (hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances)", + "output": "MARKED SINUS BRADYCARDIA (Finding)" + }, + { + "input": "Definition: Suturing unit described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: cellular response to biphenyl (Cell Function)\tTAC1 Gene Product (Amino Acid, Peptide, or Protein)\tSuture Units, Automated (Suturing unit)\tFactor B Inhibitor LNP023 (Biological Response Modifiers)\tBreast Carcinoma Clinical TNM Finding v8 (Breast Cancer TNM Finding v8)", + "output": "Suture Units, Automated (Suturing unit)" + }, + { + "input": "Definition: Finding described as a pathologic primary tumor TNM stage finding. The definition of pT2 stage finding depends on the particular type of cancer that it refers to; for example, for breast cancer, pT2 stage finding is defined as follows: cancer with tumor size more than 2.0 cm, but not more than 5.0 cm in greatest dimension; for colorectal cancer, pT2 stage finding is defined as follows: cancer with invasion into the muscularis propria.\nConcepts: anthracycline (Naphthacenes)\tR360105 (RAND-36 Questionnaire Question)\tpT2 category (after operation)\tanorexics phendimetrazine tartrate (Central Nervous System Stimulants)\tClip Appliers, Vascular, Disposable, Scalp (Clip Appliers, Vascular, Disposable)", + "output": "pT2 category (after operation)" + }, + { + "input": "Definition: STXBP2 gene described as human STXBP2 wild-type allele is located within 19p13.3-p13.2 and is approximately 11 kb in length. This allele, which encodes syntaxin-binding protein 2, plays a role in intracellular vesicle trafficking and vesicle fusion with membranes. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 5.\nConcepts: MUNC18-2 (STXBP2 gene)\tSolute Carrier Family 2 (Facilitated Glucose Transporter), Member 3 wt Allele (Gene or Genome)\tTrait, Heritable Quantitative (Inheritance Patterns)\trnax support of medical regimen compliance (Health Care Activity)\tBN (Gene or Genome)", + "output": "MUNC18-2 (STXBP2 gene)" + }, + { + "input": "Definition: something described as a rare disorder of the immune system with wide-ranging effects which include GATA2 Transcription Factor dysfunction, immunodeficiency, myelodysplastic syndrome (ineffective blood cell production), lung disease, and problems of the vascular and lymphatic system.\nConcepts: WHLINT (Clinical Interpretation)\tImmunodeficiency type 21 (Immunologic Deficiency Syndromes)\tDLEC1 (Biologically Active Substance)\tchamomilla matricaria/german (Homeopathic remedies letter C)\tMicroenvironments, Cellular (Natural Phenomenon or Process)", + "output": "Immunodeficiency type 21 (Immunologic Deficiency Syndromes)" + }, + { + "input": "Definition: ligase activity described as catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.\nConcepts: ribosomal small subunit assembly (ribonucleoprotein complex assembly)\tEncephalopathy, Hypertensive (Brain Diseases, Metabolic)\tAcute Myeloid Leukemia (AML) with t(6;11)(q27;q23); KMT2A-MLLT4 (Neoplastic Process)\tligase activity, forming carbon-carbon bonds (Molecular Function)\tPyroninophilia (Laboratory test finding)", + "output": "ligase activity, forming carbon-carbon bonds (Molecular Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a support gel for clinical use is a device that consists of an agar or agarose preparation that is used while measuring various kinds of, or parts of, protein molecules by various immunochemical techniques, such as immunoelectrophoresis, immunodiffusion, or chromatography.\nConcepts: beta-1,2-xylosyltransferase activity (UDP-xylosyltransferase activity)\tASD (MYO ENDO PERICARDIAL & VALVE DISORDERS)\tTransanal Total Mesorectal Excision (Transanal Excision)\tSUPPORT GELS (Indicator, Reagent, or Diagnostic Aid)\tMalignant Granular Cell Myoblastoma (GRANULAR CELL TUMORS AND ALVEOLAR SOFT PART SARCOMA)", + "output": "SUPPORT GELS (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as scanning systems designed to generate an image of tissue in a given plane of the body using near-infrared (NIR) laser light sources, usually at more than one frequency (i.e., a process known as NIR spectroscopy). The light detected after passing across the tissue is analyzed to determine the absorption and changes in speed. This results in optical slices that are reconstructed to form a continuous image showing the chemical composition of tissue that can be viewed as a colored image on a video display terminal. These systems can be used in diagnostic procedures to differentiate tissues according their chemical and/or molecular composition; dedicated systems used to obtain intravascular images are available.\nConcepts: Near-Infrared Spectrography Laser Scanning Systems (Scanning Systems, Laser)\tSACCHAROGENIC, AMYLASE (Indicator, Reagent, or Diagnostic Aid)\tundef.prntng edkshn/skls trn (Parenting education and/or skills training)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Enterococcus Species, rRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Enterococcus Species)\tAtrioventricular canal (Congenital Abnormality)", + "output": "Near-Infrared Spectrography Laser Scanning Systems (Scanning Systems, Laser)" + }, + { + "input": "Definition: Genes, cdc described as this gene plays a role in mitosis.\nConcepts: HCC (Malignant neoplasm of liver and intrahepatic bile ducts)\tBRD4 gene (Genes, cdc)\tSubject Elements Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)\tClean Rooms, Laminar Air Flow (Clean Rooms)\t15-deoxyspergualin hydrochloride (Organic Chemical)", + "output": "BRD4 gene (Genes, cdc)" + }, + { + "input": "Definition: something described as a condition in which some or all of the cells of the body contain extra genetic material from chromosome 18. Clinical features of this condition may include the following: spina bifida, hearing loss, cleft lip, cleft palate, undescended testes, rocker bottom feet, micrognathia, low set ears, cardiac anomalies (ventricular septal defect, atrial septal defect, patent ductus arteriosus, tetralogy of Fallot), intellectual disability, holoprosencephaly, pituitary dysplasia, seizures, autoimmune disorders, hip dysplasia, and/or congenital cataracts.\nConcepts: regulation of bipolar cell growth (regulation of unidimensional cell growth)\tAppropriateness of emotion (Emotions)\tEmergency Medicine Administration Procedure Kit/Trays (Medical Device)\t18q-Syndrome (Deletion of part of autosome)\tguanosine diphosphate (Ribonucleotides)", + "output": "18q-Syndrome (Deletion of part of autosome)" + }, + { + "input": "Definition: something described as interconnected system that is used in the automatic acquisition, storage, manipulation, movement, control, display, interchange, transmission, routing or reception of data or information, including computers, ancillary equipment, system software, support services, and related resources.\nConcepts: Granulosa Cell Tumor (Malignant Granulosa Cell Tumor)\tUltrasonic Surgical Aspiration (Therapeutic or Preventive Procedure)\tcommunications technology (Intellectual Product)\tbrain sand (Deposition)\tGram/meter2 (Quantitative Concept)", + "output": "communications technology (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to Neisseria meningitidis (i.e., meningococci) type W135, a species of bacterium of the family Neisseriaceae. These bacteria may cause meningococcemia and/or meningococcal meningitis.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis W135, IgG Antibody (Medical Device)\tGrade 3 Olfactory nerve disorder (Finding)\tnursing service (Health Care Activity)\t17p11.1 (Chromosome band)\tATLAS - Leukocyte Count (Intellectual Product)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis W135, IgG Antibody (Medical Device)" + }, + { + "input": "Definition: EKG: old myocardial infarction described as an electrocardiographic finding, in the presence of an old or age indeterminate inferior wall myocardial infarction, of Q waves greater than or equal to 40 ms in duration in the right ventricular leads V4R through V6R.\nConcepts: ERBB2 A775 G776insYVMA (Cell or Molecular Dysfunction)\tOld or Age Indeterminate Right Ventricular Myocardial Infarction by EKG Finding (Finding)\tmine (Extraction and Processing Industry)\tnoded (Other Anatomic Concept)\tIroning Board Scales (Medical Device)", + "output": "Old or Age Indeterminate Right Ventricular Myocardial Infarction by EKG Finding (Finding)" + }, + { + "input": "Definition: something described as DNA dC->dU-editing enzyme APOBEC-3F (373 aa, ~45 kDa) is encoded by the human APOBEC3F gene. This protein plays a role in the inhibition of viral genome replication.\nConcepts: Tumor Identifier Location (Location)\tAsthma Syndromes, Aspirin-Induced (Adverse reaction to antiplatelet agent)\tmucopolysaccharidosis (Disorder of glycosaminoglycan metabolism)\tFAC061-I Have Trouble With My Bowels (Intellectual Product)\tapolipoprotein B mRNA-editing enzyme catalytic polypeptide-like protein 3F, human (Enzyme)", + "output": "apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like protein 3F, human (Enzyme)" + }, + { + "input": "Definition: Immunologic Factor described as a topical formulation containing the macrolide sirolimus (rapamycin), which is produced by the organism Streptomyces hygroscopicus, with potential anti-proliferative activity. Upon application of topical sirolimus, this agent migrates into the skin and is internalized by the affected cells. In turn, sirolimus binds to the immunophilin FK binding protein-12 (FKBP-12) and forms a sirolimus:FKBP-12 complex. This complex binds to and inhibits the activity of the serine/threonine kinase mammalian target of rapamycin (mTOR). It also decreases the production of vascular endothelial growth factor (VEGF) and results in the suppression of cellular proliferation.\nConcepts: Rectal Leiomyoma (Neoplastic Process)\tTopical Sirolimus (Immunosuppressive Agents)\tbones pelvic (Body Part, Organ, or Organ Component)\tStudy Category (Intellectual Product)\tChloride Clearance Measurement (Laboratory Procedure)", + "output": "Topical Sirolimus (Immunosuppressive Agents)" + }, + { + "input": "Definition: Syringes described as a piston syringe is a device intended for medical purposes that consists of a calibrated hollow barrel and a movable plunger. At one end of the barrel there is a male connector (nozzle) for fitting the female connector (hub) of a hypodermic single lumen needle. The device is used to inject fluids into, or withdraw fluids from, the body.\nConcepts: anti-LAG-3 MoAb REGN3767 (Immunologic Factor)\tabsolute risk (Statistical Technique)\tUPD2202 (MDS-UPDRS Questionnaire Question)\tPiston Syringes (Medical Device)\talterations taste (Chemotherapy: Disruptive Physical Effects)", + "output": "Piston Syringes (Medical Device)" + }, + { + "input": "Definition: Skeleton of mouth described as alveolar arch which has as direct parts the bony alveolar arch of maxilla and maxillary gingiva.\nConcepts: Stage IV Rectal Neuroendocrine Tumor AJCC v8 (Neoplastic Process)\tUpper bony alveolar arch (Alveolar ridge)\tPerformedMedicalConditionResult.clinicallySignificantIndicator (Clinically Significant Indicator)\tPotassium Bichromate (Photographic chemical product)\tSF-36 v1.0 Acute - Question 4a (SF36 v1 0 Acute Questionnaire Question)", + "output": "Upper bony alveolar arch (Alveolar ridge)" + }, + { + "input": "Definition: Spatial Concept described as physical location of FGF21_Gene\nConcepts: alpha-hydroxymuconic epsilon-semialdehyde dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)\tNonossified fifth metatarsal (Finding)\t19: 53951306-53953289 (Spatial Concept)\teosinophilic granulocyte homeostasis (leukocyte homeostasis)\t2H (Inorganic Chemicals)", + "output": "19: 53951306-53953289 (Spatial Concept)" + }, + { + "input": "Definition: RGS22 gene described as human RGS22 wild-type allele is located in the vicinity of 8q22.2 and is approximately 170 kb in length. This allele, which encodes regulator of G-protein signaling 22 protein, is involved in the positive regulation of GTPase activity and the negative regulation of receptor signaling.\nConcepts: Remunerations (Income)\tGrade 3 Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE (Injury, Poisoning and Procedural Complications - Other, Specify, CTCAE)\tSin Nombre virus (Genus Orthohantavirus)\tEpithelin 1 (Amino Acid, Peptide, or Protein)\tPRTD-NY2 (Gene or Genome)", + "output": "PRTD-NY2 (Gene or Genome)" + }, + { + "input": "Definition: Hepatocellular damage and hepatitis NEC described as damage to liver structure or function due to trauma or toxicity.\nConcepts: regulation of collagen synthesis (regulation of collagen metabolic process)\tliver; injury (Abdominal cavity injury)\tvanillate amino acid synthetase activity (acid-D-amino acid ligase activity)\tLate Preterm Infant (Age Group)\tProgram, Regional Medical (Regional Health Planning)", + "output": "liver; injury (Abdominal cavity injury)" + }, + { + "input": "Definition: Chromosome 14 Physical Location described as physical location of CDKN3_Gene\nConcepts: Square Planar 1 (Orientation)\tFAD synthesis (Molecular Function)\tGene Expression Modulator 231 (Nucleic Acid, Nucleoside, or Nucleotide)\tMorphology Findings Domain (Domain)\t14: 53933476-53956682 (Chromosome 14 Physical Location)", + "output": "14: 53933476-53956682 (Chromosome 14 Physical Location)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of a variable number of incomplete, C-shaped cartilaginous rings encircling the anterolateral portion of the trachea, which are horizontally stacked and separated by narrow intervals throughout the length of the trachea.\nConcepts: CRYOFBRN (Measurement of substance)\tglomerular endothelium development (endothelium development)\tRefractory Primary Central Nervous System Lymphoma (Refractory Lymphoma)\tALVAC-CEA (6D)-B7.1 (ALVAC-CEA vaccine)\tTrachea Cartilage (Cartilage)", + "output": "Trachea Cartilage (Cartilage)" + }, + { + "input": "Definition: RDQ Questionnaire Question described as roland Morris Disability Questionnaire (RDQ) Because of my back, I go upstairs more slowly than usual.\nConcepts: BLVRA (Enzyme)\tPhysicians; Physician/Osteopath; Pain Management - Anesthesiology (Physicians; Physician/Osteopath)\tbeta-glucoside catabolic process (beta-glucoside metabolic process)\tFAC061-Bothered by Treatment Side Effect (FACT-BMT Version 4 Questionnaire Question)\tRDQ01-Go Upstairs More Slowly (Intellectual Product)", + "output": "RDQ01-Go Upstairs More Slowly (Intellectual Product)" + }, + { + "input": "Definition: Language described as a Trukic language of the Austronesian language family spoken primarily on the islands of Chuuk in the Caroline Islands in Micronesia.\nConcepts: RA - Retinoic acid product (Targeted Therapy Agent)\t17-alpha-Hydroxypregnanolone (Progesterone derivative)\tregulation of vein smooth muscle contraction (regulation of vascular smooth muscle contraction)\tpositive regulation of cyclin-dependent protein kinase activity (regulation of cyclin-dependent protein serine/threonine kinase activity)\tCHK (Language)", + "output": "CHK (Language)" + }, + { + "input": "Definition: something described as a morphologic variant of classic leiomyoma characterized by a dense cellular infiltrate composed of spindle or round cells with scant cytoplasm and a less obvious interlacing fascicle pattern.\nConcepts: Cellular leiomyoma (Neoplastic Process)\tAortic arch calcification (Thoracic aorta calcification)\tpolymeric camptothecin prodrug XMT-1001 (Topoisomerase I Inhibitors)\thost cell plasma membrane (host cell membrane)\tInvestigational Product Communications and Tracking Documentation (Document type)", + "output": "Cellular leiomyoma (Neoplastic Process)" + }, + { + "input": "Definition: Organic Chemical described as a thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE.\nConcepts: 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (Organic Chemical)\thypertrophy was seen (Myopathy)\tVaccinia-CEA-MUC1-TRICOM Vaccine (Pharmacologic Substance)\tPericentriolar Material 1/Proto-Oncogene Tyrosine-Protein Kinase Receptor Ret Fusion Protein (Fusion protein)\tTunica Albuginea (Male Reproductive System Part)", + "output": "6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide (Organic Chemical)" + }, + { + "input": "Definition: Agammaglobulinemia described as the non-syndromic form of a primary immunodeficiency disease characterized by deficient gamma globulins and associated predisposition to frequent and recurrent infections from infancy. Two forms have been described: X-linked represents approximately 85% of the affected patients, and autosomal which includes recessive and dominant cases but is far less frequent. The clinical signs of the two forms are very similar and include recurrent bacterial infections, diarrhea and skin infections with onset in infancy. Defects in B lymphocyte development and maturation appear to underlie agammaglobulinemia. Mutations in seven genes have been reported to be related to IA: BTK (Xq21.33-q22), BLNK (10q23.2-q23.33), CD79A (19q13.2), CD79B (17q23), IGHM(14q32.33), IGLL1 (22q11.23), PIK3R1 (5q13.1) and TCF3 (19p13.3).\nConcepts: rndx unilateral neglect (COGNITIVE-PERCEPTUAL PATTERNS)\tAngiosarcoma of the Ovary (Soft Tissue Angiosarcoma)\tIsolated agammaglobulinaemia (X-linked agammaglobulinemia)\tunsaturated fatty acid biosynthesis (unsaturated fatty acid metabolic process)\tregulation of phosphatidylserine exposure on apoptotic cell surface (regulation of plasma membrane organization)", + "output": "Isolated agammaglobulinaemia (X-linked agammaglobulinemia)" + }, + { + "input": "Definition: drugs identified described as a synthetic codeine analogue, Tramadol has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. Used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake.\nConcepts: Related to Another Cancer (CPTAC Questions)\tB cell homeostasis (Cell Function)\tTumor of the Gingiva (Upper Aerodigestive Tract Neoplasms)\tMinimum Thickness (Quantitative Concept)\ttramadol (Other opioids in ATC)", + "output": "tramadol (Other opioids in ATC)" + }, + { + "input": "Definition: something described as an uncommon variant of rhabdomyosarcoma with spindle cell or sclerosing morphology. It affects both children and adults and it is more common in males.\nConcepts: Myositis ossificans traumatica (Muscle, tendon and ligament injuries)\tFunction, Right Atrial (Atrial Function)\tABI-008 (Pharmacologic Substance)\tSpindle Cell/Sclerosing Rhabdomyosarcoma (Neoplastic Process)\tsyncytial embryo cellularization (Cell division)", + "output": "Spindle Cell/Sclerosing Rhabdomyosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Medical Device described as an instrument composed of multiple lenses that refract the light going into the subject's eye, allowing the examiner to determine the refractive error of the eye.\nConcepts: SCREW, FIBROID, GYNECOLOGICAL (Medical Device)\tAbsent Birbeck granules in Langerhans cells (Anatomical Abnormality)\tretinoscopy (Measurement)\tphoropters (Medical Devices)\tpositive regulation of pancreatic alpha cell differentiation (positive regulation of epithelial cell differentiation)", + "output": "phoropters (Medical Devices)" + }, + { + "input": "Definition: Radioconjugate described as a radioconjugate composed of a synthetic, cyclic pentapeptide analog of stromal-cell derived factor-1 (SDF-1 or CXCL12), which is a ligand for chemokine receptor C-X-C chemokine receptor type 4 (CXCR4), that is radiolabeled, via the macrocyclic chelating agent dodecanetetraacetic acid (DOTA), with the radioisotope gallium Ga 68 (Ga68; 68Ga), with potential use for imaging CXCR4-expressing cells upon positron emission tomography (PET)/computed tomography (CT). Upon administration of 68Ga pentixafor, the pentixafor moiety targets and binds to CXCR4-expressing cancer cells. Upon PET/CT, CXCR4-expressing cancer cells can be visualized and the expression status of the receptor can be assessed. CXCR4, a marker of poorly differentiated cells, is overexpressed on various cancer cells, and plays a key role in tumor growth, progression, invasiveness and metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C141632\" active clinical trials using this agent.\nConcepts: gastrin receptor activity (G protein-coupled peptide receptor activity)\tGa68 pentixafor (Radioconjugate)\tAssessedResultRelationship.typeCode (Type Code)\tinjuries tendon (Muscle, tendon and ligament injuries)\tFractionation, Chemical (Biomolecule Separation Technology)", + "output": "Ga68 pentixafor (Radioconjugate)" + }, + { + "input": "Definition: Surgeon described as a surgeon with advanced training in treating disfiguring conditions. Surgery may also include cosmetic surgery.\nConcepts: positive regulation of immune cell activation (positive regulation of cell activation)\tDefined Observation Result Type Code (Intellectual Product)\tplastic surgeon (Professional or Occupational Group)\tInvestigator Confidentiality Agreement (Clinical Trial Agreement)\tTLI (Language)", + "output": "plastic surgeon (Professional or Occupational Group)" + }, + { + "input": "Definition: General Qualifier described as not identified from previous encounters or knowledge.\nConcepts: ug/mL/(mg/kg/d) (Measurement Unit Description)\t11p15.3-p15.1 (Chromosome band)\tgranular cell myoblastoma (Benign neoplasm of nerve sheath origin)\tUnrecognized (General Qualifier)\tashkenazi jews (Judaism)", + "output": "Unrecognized (General Qualifier)" + }, + { + "input": "Definition: MHIS-NACC Questionnaire Question described as modified Hachinski Ischemic Scale-NACC Version (MHIS-NACC) History of stroke.\nConcepts: Malignant tumour cells (Neoplasms)\tMHIS-NACC - History of Stroke (MHIS-NACC Questionnaire Question)\tnegative regulation of pancreatic beta cell development (negative regulation of multicellular organismal process)\tSarcoma Surgery (cancer surgery)\tprimary amine secretion, neurotransmission (Cell Function)", + "output": "MHIS-NACC - History of Stroke (MHIS-NACC Questionnaire Question)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as echovirus serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to echovirus in serum. Additionally, some of these reagents consist of echovirus antisera conjugated with a fluorescent dye used to identify echoviruses from clinical specimens or from tissue culture isolates derived from clinical specimens. The identification aids in the diagnosis of echovirus infections and provides epidemiological information on diseases caused by these viruses. Echoviruses cause illnesses such as meningitis (inflammation of the brain and spinal cord membranes), febrile illnesses (accompanied by fever) with or without rash, and the common cold.\nConcepts: positive regulation of ryanodine-sensitive calcium-release channel activity (positive regulation of calcium-mediated signaling)\tBehavioral (Intellectual Product)\tAdult Stage I Lymphoblastic Lymphoma (Ann Arbor Stage I Aggressive Adult Non-Hodgkin Lymphoma)\tANTISERA, CF, ECHOVIRUS 1-34 (Indicator, Reagent, or Diagnostic Aid)\tNCCN-FACT FBLSI-18 Version 2 - I Have a Lack of Energy (Intellectual Product)", + "output": "ANTISERA, CF, ECHOVIRUS 1-34 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2,4-diaminopentanoate + H2O + NAD(P)+ = 2-amino-4-oxopentanoate + NH3 + NAD(P)H + H+.\nConcepts: BK Virus (Virus)\tup-regulation of respiratory-chain phosphorylation (Molecular Function)\tlistening (Vestibulocochlear Physiological Phenomena)\t2,4-diaminopentanoate:NAD(P)+ oxidoreductase (Molecular Function)\tup-regulation of cell division (regulation of cell division)", + "output": "2,4-diaminopentanoate:NAD(P)+ oxidoreductase (Molecular Function)" + }, + { + "input": "Definition: Locally Advanced Head and Neck Carcinoma described as thyroid gland medullary carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.\nConcepts: SFMP2-Piercing (Short-Form MPQ-2 Questionnaire Question)\tmetanephric nephron epithelium development (nephron epithelium development)\tCEREBELLOPARENCHYMAL DISORDER III (Hereditary cerebellar degeneration)\tLocally Advanced Thyroid Gland Medullary Carcinoma (Metastatic Thyroid Gland Medullary Carcinoma)\tarea 9m (Body Location or Region)", + "output": "Locally Advanced Thyroid Gland Medullary Carcinoma (Metastatic Thyroid Gland Medullary Carcinoma)" + }, + { + "input": "Definition: negative regulation of mitotic cell cycle described as any process that stops, prevents or reduces the frequency, rate or extent of mitotic cytokinesis.\nConcepts: Carcinomas, Oat Cell (Malignant epithelial neoplasm - category)\tAmbrette Seed Oil (Organic Chemical)\tdown regulation of cytokinesis after mitosis (Cell Function)\tNeurovirology (Biomedical Occupation or Discipline)\tcells fibroblast (Cells)", + "output": "down regulation of cytokinesis after mitosis (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein encoded by the NPPA gene.\nConcepts: negative regulation of triglyceride transport (Molecular Function)\tNPPA Gene Product (peptide hormone)\tStudy Protocol Version Adverse Event Coding System (Adverse Event Coding System)\tMelanoma Antigen Family A, 1 (Directs Expression of Antigen MZ2-E) wt Allele (Gene or Genome)\tfirst subject treated - date, time (Date/Time)", + "output": "NPPA Gene Product (peptide hormone)" + }, + { + "input": "Definition: something described as an extended release (ER) oral tablet that contains flucytosine (5-FC), a fluorinated cytosine analog, with antifungal activity and potential anti-cancer activity. Following oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil (5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream protein synthesis. In addition, 5-FU is metabolized further to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase. Inhibition of this enzyme interrupts nucleotide synthesis, DNA replication and cell proliferation. Negative regulation of protein synthesis, DNA replication and cell proliferation can lead to cell death. Following ingestion of ER 5-FC, intravenous injection of a retroviral vector encoding cytosine deaminase (TC 511) at a tumor site may result in higher local concentrations of 5-FU and its metabolites, and increased tumor cell death than other 5-FU treatment regimens.\nConcepts: Have you had trouble eating in front of other people (Intellectual Product)\tNPI1A12 (NPI Questionnaire Question)\textended-release flucytosine (pyrimidine analog)\tEnzalutamide (Substance with benzamide structure)\tGrade 2 Rhabdomyolysis (Rhabdomyolysis, CTCAE)", + "output": "extended-release flucytosine (pyrimidine analog)" + }, + { + "input": "Definition: Finding described as a type of exocardia in which the heart develops outside of the body.\nConcepts: Sequence Tagged Site (Genetic Markers)\tG Protein Gene (Signaling Pathway Gene)\tdexamethasone sustained-exposure formulation OTO-104 (Protective Agents)\tHNF3A (Gene or Genome)\tExternalized Heart (Finding)", + "output": "Externalized Heart (Finding)" + }, + { + "input": "Definition: something described as the deformation and flow behavior of BLOOD and its elements i.e., PLASMA; ERYTHROCYTES; WHITE BLOOD CELLS; and BLOOD PLATELETS.\nConcepts: Cascara sagrada / sacred bark (Organic Chemical)\tHEMORHEOL (Blood Physiological Phenomena)\tMajor Salivary Gland Cancer Pathologic Distant Metastasis TNM Finding v7 (Major Salivary Gland Cancer Pathologic TNM Finding v7)\tHEPATOLENTICULAR DEGENERATION (Movement Disorders)\toxidative stress (Oxidation)", + "output": "HEMORHEOL (Blood Physiological Phenomena)" + }, + { + "input": "Definition: Proteins described as serum beta globin that transports and binds iron.\nConcepts: 1q21.1 microduplication syndrome (Partial trisomy of long arm of chromosome 1)\tAutologous Dendritic Cell-Adenovirus P53 Vaccine (Dendritic Cell Vaccine)\talimentary tracts (Digestive organ structure)\tMetal-Binding Globulin, beta-1 (beta Globulin)\tDesign, construction and building products and technology of buildings for public use (CHAPTER 1 PRODUCTS AND TECHNOLOGY)", + "output": "Metal-Binding Globulin, beta-1 (beta Globulin)" + }, + { + "input": "Definition: Polycythemia Vera described as polycythemia vera characterized by the proliferation of the erythroid, granulocytic, and megakaryocytic lineages. The peripheral blood shows excess of red blood cells, neutrophilia, and thrombocytosis. The bone marrow is hypercellular for the patient's age.\nConcepts: Liver Kidney Microsomal Type 1 IgA Antibody Measurement (Laboratory Procedure)\tCYSTINOSIS, NEPHROPATHIC (Disease or Syndrome)\tPolycythemia Vera, Polycythemic Phase (Neoplastic Process)\tBEBQ01-Baby Takes More Than 30 Minutes (Intellectual Product)\tFemale genital mutilation type 3a (Acquired Abnormality)", + "output": "Polycythemia Vera, Polycythemic Phase (Neoplastic Process)" + }, + { + "input": "Definition: something described as the total number of hospitalization events that have occurred for the condition.\nConcepts: Number Of Hospitalizations (Quantitative Concept)\tpublic health nurs (Specialties, Nursing)\tlabour (Pregnancy)\tsmelling (Perception)\tGrade 2 Localized Edema, CTCAE (Localized Edema, CTCAE)", + "output": "Number Of Hospitalizations (Quantitative Concept)" + }, + { + "input": "Definition: something described as digital image data sets, created by the NATIONAL LIBRARY OF MEDICINE, consisting of complete, anatomically detailed, three-dimensional representations of the normal male and female human bodies. The images were generated from carefully selected and prepared CADAVERS in three modes: computerized tomography (TOMOGRAPHY, X-RAY COMPUTED), magnetic resonance (MAGNETIC RESONANCE IMAGING) and cryosection (CRYOSECTIONING).\nConcepts: Right Lung, Inferior Lobe, Posterior Basal Segment (Body Part, Organ, or Organ Component)\tPaeniclostridium sordellii (Clostridium species q-z)\tARC complex (Cell Component)\tAntitachycardia Pacing (Therapeutic or Preventive Procedure)\tAmerican Visible Human Project (Intellectual Product)", + "output": "American Visible Human Project (Intellectual Product)" + }, + { + "input": "Definition: Protein-arginine deiminase described as a peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.\nConcepts: Oligonucleotide Synthesis (Laboratory Procedure)\tPeptidylarginine Deiminase Type 1 (Protein-arginine deiminase)\tLy57 (BLNK gene)\tregulation by host of viral genome reproduction (Cell Function)\tlipopolysaccharide transmembrane transporter activity (carbohydrate derivative transmembrane transporter activity)", + "output": "Peptidylarginine Deiminase Type 1 (Protein-arginine deiminase)" + }, + { + "input": "Definition: something described as solvent-free method for preparing numerous types of drug delivery systems and dosage forms for active pharmaceutical ingredients that have solubility issues. It involves pumping polymeric materials at temperatures above their glass transition temperature to mix in active pharmaceutical ingredients with or without binders thus forming an amorphous product with an increase in the dissolution profile for the active pharmaceutical ingredients.\nConcepts: Hot Melt Extrusion (Research Activity)\tBeckwith's syndrome (Congenital macroglossia)\tMDS-UPDRS - Right Leg Agility (Intellectual Product)\tSpecies Differences (systematic biology)\tStage III Thyroid Gland Medullary Cancer (Thyroid Gland Medullary Carcinoma by AJCC v8 Stage)", + "output": "Hot Melt Extrusion (Research Activity)" + }, + { + "input": "Definition: something described as a radiographic procedure using the emission of penetrating energy waves to form an image of the structure penetrated by the radiation.\nConcepts: Providing vitamin D based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis. (Source: IDNT Reference Manual, edition 4; ISBN #978-0-88091-467-3). (Inorganic salt/vitamin prophylaxis)\tElectrical Wire Device (Manufactured Object)\tisocortex, deep supragranular pyramidal layer (proper sensory nucleus)\tADPase (nucleoside-diphosphatase activity)\tRadiography (Diagnostic Procedure)", + "output": "Radiography (Diagnostic Procedure)" + }, + { + "input": "Definition: COSTART described as a biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level.\nConcepts: Pathological process (health and disease)\tDesmopressin product (Hemostatic Agents)\txian ling gu bao (Agent Affecting Musculoskeletal System)\tFAC017-I Feel Nervous (FACT-LEU Version 4 Questionnaire Question)\tSerotonin 4 Receptor (Receptor)", + "output": "Pathological process (health and disease)" + }, + { + "input": "Definition: Intellectual Product described as hamilton Depression Rating Scale 6 Clinician Version (HAM-D6 Clinician Version) Psychomotor retardation, general.\nConcepts: Stratum synoviale (ARTICULAR SYSTEM: GENERAL TERMS)\tHAMD4-Psychomotor Retardation, General (HAM-D6 Clinician Version Clinical Classification Question)\tComparative Score 1+ (Finding)\tDental Impression Materials, Alginate (Biomedical or Dental Material)\tPackage.capacityQuantity (Capacity)", + "output": "HAMD4-Psychomotor Retardation, General (HAM-D6 Clinician Version Clinical Classification Question)" + }, + { + "input": "Definition: Professional or Occupational Group described as a doctor who identifies diseases by studying cells and tissues under a microscope.\nConcepts: PATHOLOGIST (Physicians)\tWOMAC LK 3.1 INDEX (Clinical or Research Assessment Questionnaire)\tMathematics Anxiety (Mental Process)\tnegative regulation of natural killer cell differentiation (regulation of natural killer cell differentiation)\tVaginal Cancer pT2b TNM Finding v8 (Finding)", + "output": "PATHOLOGIST (Physicians)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions and duplications in genes associated with autism spectrum disorder, a collection of conditions that exhibit deficits in social communication and interaction and restricted and/or repetitive behavioral patterns, interests, and activities. Genetic variants at multiple loci have been associated with autism spectrum disorder. These reagents are intended to detect deletions and duplications in multiple autism spectrum disorder-associated loci simultaneously.\nConcepts: Adenin (nucleobase)\tBiofortification (Occupation or Discipline)\tUPD2313 (MDS-UPDRS Questionnaire Question)\testablishment of contractile ring localization involved in cell cycle cytokinesis (actomyosin contractile ring localization)\tIVD Panels, Human Genetics, Encephalopathy, Autism Spectrum Disorder, Del/Dup (Medical Device)", + "output": "IVD Panels, Human Genetics, Encephalopathy, Autism Spectrum Disorder, Del/Dup (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as a number that identifies the ordering relations (in time, space, etc.) in a set of pharmacokinetic parameters.\nConcepts: Pituitary hyperadrenal corticism (Cushing Syndrome)\tIntracameral use (Functional Concept)\tL-valine ester with 9-((2-hydroxyethoxy)methyl)guanine hydrochloride (valacyclovir)\tsarcoma of meninges (sarcoma of central nervous system)\tPharmacokinetic Parameter Sequence Number (Sequence Number)", + "output": "Pharmacokinetic Parameter Sequence Number (Sequence Number)" + }, + { + "input": "Definition: Finding described as baseline Dyspnea Index - Baseline focal score.\nConcepts: Mineral Oil, High Viscosity (Industrial Aid)\tstanding ndvdl ea.15min (Ergonomics training)\tMicrofluorometries, Flow (Medical Devices)\tBDI - Baseline Focal Score (Finding)\tDisease due to Respirovirus (Disease due to Paramyxovirinae)", + "output": "BDI - Baseline Focal Score (Finding)" + }, + { + "input": "Definition: CEA Family Gene described as this gene plays a probable role in both cell-cell signaling and cell adhesion.\nConcepts: CDISC Questionnaire PedsQL Neuromuscular Module Version 3.0 Young Adult Report Test Name Terminology (CDISC Questionnaire Terminology)\tAnalyzers, Point-of-Care, Whole Blood, Gas/pH (Medical Device)\tTarget Audience (Population Group)\tCEA-LIKE PROTEIN (Gene or Genome)\tPeriodic Paralysis, Potassium Sensitive Cardiodysrhythmic Type (Structural disorder of heart)", + "output": "CEA-LIKE PROTEIN (Gene or Genome)" + }, + { + "input": "Definition: Metallopeptidase Gene described as this gene plays a role in proteolysis of collagen.\nConcepts: 4 (Finding)\tAnal Atresia (External features)\tTherapeutic Mouth Procedure (Therapeutic procedure)\tAnti-CD70 Monoclonal Antibody MDX-1411 (Antineoplastic Antibody)\tmatrix metallopeptidase 13 (Metallopeptidase Gene)", + "output": "matrix metallopeptidase 13 (Metallopeptidase Gene)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire - During the past week, how often have you: Concentrated on work?\nConcepts: regulation of gastric motility (Organ or Tissue Function)\tMicroalbumin (Protein or Enzyme Type Measurement)\tAutologous Anti-CTLA-4/PD-1 Expressing EGFR-CAR-T Cells (T-cell Receptor-engineered T-cells)\tQ-LES-Q - Concentrated on Work (Intellectual Product)\tmanic (Abnormal behavior)", + "output": "Q-LES-Q - Concentrated on Work (Intellectual Product)" + }, + { + "input": "Definition: something described as the presence of yeast.\nConcepts: Prominent ear helix (Abnormality of the helix)\tUnknown Primary Tumor cN3a TNM Finding v8 (Finding)\tGrade 1 Neonatal Respiratory Insufficiency (Neonatal Respiratory Insufficiency, Adverse Event)\tElectric Capacitance Unit (Unit of Electricity and Magnetism)\tYeast Present (Laboratory or Test Result)", + "output": "Yeast Present (Laboratory or Test Result)" + }, + { + "input": "Definition: Person Role Title described as a descriptive or distinctive appellation, especially one belonging to a person by right of rank, office, attainment, etc.\nConcepts: regulation of (R)-carnitine transmembrane transport (regulation of cation transmembrane transport)\tDermatitis irritant contact (Korean Standard Classification of Disease Version 5)\tOuter Canthus (Head and Neck Part)\tOrganizational Contact Title (Intellectual Product)\tPHQ02-Trouble Sleeping (Intellectual Product)", + "output": "Organizational Contact Title (Intellectual Product)" + }, + { + "input": "Definition: something described as development of or conversion into keratin.\nConcepts: Grey matter heterotopia (Congenital Abnormality)\tPseudohermaphroditism NOS (CONGENITAL ANOMALIES OF THE GENITAL SYSTEMS: GENERAL CONDITIONS)\tDownstream Gene Variant (Gene Mutation)\tkeratinization (Skin growth)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2 Postpartum Hemorrhage (Intellectual Product)", + "output": "keratinization (Skin growth)" + }, + { + "input": "Definition: Intellectual Product described as a clinical outcome instrument to measure the severity of epidermal chronic graft versus host disease. Extent of cutaneous involvement is scored using a 5 point scale.\nConcepts: Stage IIIB Digestive System Neuroendocrine Tumor AJCC v7 (Neoplastic Process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SDHD (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tPhysician's Global Assessment Scale of Epidermal Chronic Graft versus Host Disease (Research or Clinical Assessment Tool)\tEpoetin Alfa Regimen (Regimen Used to Treat Non-neoplastic Hematologic Disorders)\tSyndrome, Bourneville (Heredodegenerative Disorders, Nervous System)", + "output": "Physician's Global Assessment Scale of Epidermal Chronic Graft versus Host Disease (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as this gene plays a role in both transcriptional regulation and histone methylation.\nConcepts: WTAP Gene (Gene or Genome)\tEPS8-Like 1 (Amino Acid, Peptide, or Protein)\tPAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1 (Transcription Regulation Gene)\tStudy Type (Clinical Trial Type)\tHypoplastic spleen (Spleen)", + "output": "PAXIP1-ASSOCIATED GLUTAMATE-RICH PROTEIN 1 (Transcription Regulation Gene)" + }, + { + "input": "Definition: something described as physical location of ADORA3_Gene\nConcepts: Cytochrome P-450 CYP3A4 (Enzyme)\tLymphohistiocytoses, Hemophagocytic (Rare Non-Neoplastic Disorder)\tJumping Gene (DNA Insertion Elements)\tEntire vestibular ligament (Entire fascia of head, orbit AND/OR neck)\t1: 111758785-111754097 (Chromosome 1 Physical Location)", + "output": "1: 111758785-111754097 (Chromosome 1 Physical Location)" + }, + { + "input": "Definition: Breast Carcinoma described as a breast carcinoma characterized by the presence of multiple cancerous tumors that originate from the same clone and are usually located in the same quadrant of the breast.\nConcepts: Abnormality of circulating beta2 microglobulin level (Abnormal circulating beta globulin level)\tregulation of granuloma formation (regulation of immune effector process)\t10 Proteins, HOXA (Biologically Active Substance)\tMultifocal breast cancer (Neoplastic Process)\tHADS01-I Feel Tense or Wound Up (HADS Questionnaire Question)", + "output": "Multifocal breast cancer (Neoplastic Process)" + }, + { + "input": "Definition: Europe, Eastern described as a country in southeastern Europe and southwestern Asia (that portion of Turkey west of the Bosporus is geographically part of Europe), bordering the Black Sea, between Bulgaria and Georgia, and bordering the Aegean Sea and the Mediterranean Sea, between Greece and Syria.\nConcepts: downregulation of mRNA cap binding (regulation of mRNA cap binding)\tDuring sexual intercourse, how often were you able to maintain your erection after you had penetrated (entered) your partner (Intellectual Product)\tTUR (Asia, Southeastern)\tBMND1 (Gene or Genome)\tArg/Abl-Interacting Protein 2 (Amino Acid, Peptide, or Protein)", + "output": "TUR (Asia, Southeastern)" + }, + { + "input": "Definition: something described as high efficiency particulate filter air cleaners mounted on wheeled platforms and specially designed for mobile applications. These cleaners are intended for movement from one location to another. In a healthcare facilities, modular medical facilities (both stationary and mobile), and in emergency shelters they may be used to protect from toxic industrial contaminants and biological agents or radioactive particulates.\nConcepts: Illegitimacy (Finding)\tDNA (cytosine-5-)-methyltransferase 1 (Gene or Genome)\tintegral to synaptic vesicle membrane (intrinsic component of synaptic vesicle membrane)\tAir Cleaners, Particulate, High-Efficiency Filter, Mobile (Medical Device)\tBCAP Regimen (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "Air Cleaners, Particulate, High-Efficiency Filter, Mobile (Medical Device)" + }, + { + "input": "Definition: Anti-GD2 Monoclonal Antibody described as a monoclonal antibody directed against human glycosphingolipid GD2 with potential antineoplastic activity. Upon binding to the GD2 antigen, anti-GD2 monoclonal antibody hu14.18K322A triggers a host immune response against GD2-expressing tumor cells, which may result in tumor cell death. GD2, an O-acetylated disialoganglioside with expression in normal tissues restricted primarily to the cerebellum and peripheral nerves, is commonly expressed at high levels on tumors of neuroectodermal origins such as melanomas and neuroblastomas. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80042\" active clinical trials using this agent.\nConcepts: Neuroectodermal melanolysosomal disease (Hyperpigmentation)\tInterleukin 15 (Cytokine Measurement)\tlate recombination nodule (Cell Component)\tVocational assessment (Health Care Activity)\tanti-GD2 monoclonal antibody hu14.18K322A (Antineoplastic Antibody)", + "output": "anti-GD2 monoclonal antibody hu14.18K322A (Antineoplastic Antibody)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the basophils to total cells in a biological specimen (for example a bone marrow specimen).\nConcepts: Basophil to Total Cell Ratio Measurement (Laboratory Procedure)\tMILK THISTLE (Organic Chemical)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL4A5 (Medical Device)\tALK Tyrosine Kinase Receptor F1245X (ALK Protein Variant)\tLumbar Support Pillows (Orthoses and Supports)", + "output": "Basophil to Total Cell Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as one of two premammillary nuclei in the macaque ( Bleier-1984 ), the rat ( Swanson-1998 ) and the mouse ( Hof-2000 ). The other is the ventral premammillary nucleus. Neither of the premammillary nuclei is discernable by Nissl stain in the human ( Saper-2004 ). Functionally it is part of the behavior control column of the subcortical motor system ( Swanson-2004 ).\nConcepts: BCMA-CD3 bispecific Ab PF-06863135 (Pharmacologic Substance)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Campylobacter jejuni, RRNA (Medical Device)\tSpecial program education community (Public health service)\tdorsal premammillary nucleus (behavior control column)\tAnal Carcinoma Pathologic TNM Finding v8 (Finding)", + "output": "dorsal premammillary nucleus (behavior control column)" + }, + { + "input": "Definition: Osteopathic manipulation described as rhythmic compression applied over the spleen for the purpose of enhancing the patient's immune response.\nConcepts: CSS04-Most Lethal Attempt Damage (C-SSRS Baseline/Screening Version Questionnaire Question)\tDE (Functional Concept)\tmitotic DNA replication preinitiation complex assembly (DNA replication preinitiation complex assembly)\tSplenic pump technique (Lymphatic pump)\tEMSY Gene Amplification (Gene Amplification Abnormality)", + "output": "Splenic pump technique (Lymphatic pump)" + }, + { + "input": "Definition: Malignant fibrohistiocytic neoplasm - category described as a soft tissue sarcoma that usually occurs in the limbs, most commonly the legs, and may also occur in the abdomen.\nConcepts: Storiform-Pleomorphic Malignant Fibrous Histiocytoma (Neoplasms)\tBroad ulna (Abnormal morphology of ulna)\tStudyProtocolVersion.plannedInvestigationalExposureQuotient (Planned Investigational Exposure Quotient)\tOversightCommittee.typeCode (Type Code)\tacetylene (Organic Chemical)", + "output": "Storiform-Pleomorphic Malignant Fibrous Histiocytoma (Neoplasms)" + }, + { + "input": "Definition: Neoplastic Process described as colon carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.\nConcepts: Extremity Supports (Clinical or Research Assessment Question)\tSignal Peptide, CUB and EGF-Like Domain-Containing Protein 2 (Amino Acid, Peptide, or Protein)\tAdvanced Colon Carcinoma (Metastatic Colon Carcinoma)\tDuring the past 24 hours did VOMITING or DRY HEAVES interfere with your physical activities (Intellectual Product)\tGLICONDAMIDE (Sulfonylurea Antidiabetic Agent)", + "output": "Advanced Colon Carcinoma (Metastatic Colon Carcinoma)" + }, + { + "input": "Definition: Biological Phenomena described as reproduction or reconstitution of a lost or injured part.\nConcepts: How Much Bothered by Increased Skin Sensitivity in Affected Underarm, Arm, or Hand (Intellectual Product)\tANX2 (ANXA2 gene)\tnatural regeneration (Disturbance of growth)\tReportVersion.dueDate (Due date)\tDetailed (Qualitative Concept)", + "output": "natural regeneration (Disturbance of growth)" + }, + { + "input": "Definition: something described as a 10 item symptom index scale developed from the FACT H&N questionnaire with the National Comprehensive Cancer Network to evaluate response to chemotherapy for patients with prostate cancer.\nConcepts: multiple epiphyseal dysplasia-early onset diabetes mellitus (MED-IDDM) syndrome (Multiple Epiphyseal Dysplasia)\tupregulation of homoserine formation (positive regulation of cellular amino acid biosynthetic process)\tHOX3C (Biologically Active Substance)\tBehavioral variant of frontotemporal dementia (Hereditary disorder of nervous system)\tFACT/NCCN-Prostate Symptom Index (Intellectual Product)", + "output": "FACT/NCCN-Prostate Symptom Index (Intellectual Product)" + }, + { + "input": "Definition: something described as the determination of the ratio of columnar epithelial cells compared to non-squamous epithelial cells present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: eastern equine encephalomyelitis virus (Virus)\tThyroid Gland Clear Cell Follicular Adenoma (Neoplastic Process)\tExcitatory Amino Acid Transporter 4 (Amino Acid, Peptide, or Protein)\tAbsence of part of skin at birth (Aplasia Cutis Congenita)\tColumnar Epi Cells/Non-Squam Epi Cells (Cell Count)", + "output": "Columnar Epi Cells/Non-Squam Epi Cells (Cell Count)" + }, + { + "input": "Definition: Regulation or Law described as right of peoples to self-determination and the rights to be and to live in community with other members of one's own group. The rights of communities, ranging from the family unit to the entire human community, and including national, religious, linguistic and cultural communities, taking special account of minorities, and indigenous populations.\nConcepts: Rights, Collective Human (Regulation or Law)\tAlloxanum (Miscellaneous Drugs)\tElopement Occurrence (Finding)\tconnective tissue replacement (Physiologic Function)\tcofactor required for Sp1 transcriptional activation, subunit 6, 77kDa (Gene or Genome)", + "output": "Rights, Collective Human (Regulation or Law)" + }, + { + "input": "Definition: something described as a skin appendage neoplasm with follicular differentiation. It usually occurs in the head and neck region, particularly the face. It presents as a solitary dome-shaped small lesion. The clinical course is benign.\nConcepts: Feeling worried, sad or unhappy (Intellectual Product)\tmasochism (Mental or Behavioral Dysfunction)\tRecurrent trichofolliculoma (Benign Neoplasm)\torganizations research (Manufactured Object)\tMedication administration: intradermal (drug management)", + "output": "Recurrent trichofolliculoma (Benign Neoplasm)" + }, + { + "input": "Definition: Electrophysiology described as a change in the heat and electricity passed through the skin by nerves and sweat. Skin conduction increases in certain emotional states and during hot flashes that happen with menopause.\nConcepts: DIPLA1 (Gene or Genome)\tgalvanic skin response (Electrophysiological Processes)\tGlandular stomach (Stomach)\tC5 convertase (Amino Acid, Peptide, or Protein)\tPeptidyl-Prolyl Isomerase A (Amino Acid, Peptide, or Protein)", + "output": "galvanic skin response (Electrophysiological Processes)" + }, + { + "input": "Definition: Hallucinations, Organic described as repetitive visual hallucinations experienced mostly by elderly with diminished visual acuity or visual field loss, with awareness of the fictional nature of their hallucinations. It is not associated with delusions and other sensory hallucinations.\nConcepts: swimming (Exercise)\tCharles Bonnet syndrome (Hallucinations, Visual)\t9: 21132144-21130631 (Chromosome 9 Physical Location)\tGardasil Immunogenicity with Needle-Free Injection (Research Activity)\tIL-8 secretion (cytokine secretion)", + "output": "Charles Bonnet syndrome (Hallucinations, Visual)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of mesonephric glomerulus development.\nConcepts: Organizational pattern (Conceptual Entity)\tSquirrel Monkeys (Cebinae)\tDerivation Type (UML Entity)\tregulation of mesonephric glomerulus development (Biologic Function)\tDiuretic agent (TYPES AND MISCELLANEOUS DIURETICS)", + "output": "regulation of mesonephric glomerulus development (Biologic Function)" + }, + { + "input": "Definition: Intellectual Product described as a character or string used to name, or characterize a protocol deviation reference.\nConcepts: Huntington Disease Protein (Proteins)\t9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione (Pregnanes)\tDVREFID (Reference ID)\t5'-Inosinate (Purine Nucleotides)\tADNI AVLT - List A Recall 2 Word 4 (ADNI-AVLT Questionnaire Question)", + "output": "DVREFID (Reference ID)" + }, + { + "input": "Definition: Genetic Function described as interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks.\nConcepts: StudyProtocolVersion.participatingOrganizationTypeCode (Intellectual Product)\treplication fork barrier binding (Genetic Function)\tInfection, Nematode (Helminthic disorders)\tProcedure Kit/Trays, Tick Removal (Medical Device)\t90Y (Element, Ion, or Isotope)", + "output": "replication fork barrier binding (Genetic Function)" + }, + { + "input": "Definition: something described as an ophthalmic photocoagulator is an AC-powered device intended to use the energy from an extended noncoherent light source to occlude blood vessels of the retina, choroid, or iris.\nConcepts: SUMO1/Sentrin Specific Peptidase 6 Gene (Cysteine Protease Genes)\tPHOTOCOAGULATOR AND ACCESSORIES (Medical Device)\tLung Cancer pT3 TNM Finding v7 (Lung Cancer Pathologic Primary Tumor TNM Finding v7)\tType of New Melanoma Related Tumor Event (Intellectual Product)\tOPTICAL TOMOGR (Diagnostic Procedure)", + "output": "PHOTOCOAGULATOR AND ACCESSORIES (Medical Device)" + }, + { + "input": "Definition: Patient counseling education described as any elsewhere undefined patient education and/or counseling, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: alrg prfle 1-8 Itms ea.tst (Allergy testing)\turonate: NAD-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tAlpha-n-acetylglucosaminidase measurement (Protein or Enzyme Type Measurement)\tN-glycan fucosylation (Molecular Function)\tUndefined patient education and/or counseling narrative required (Patient counseling education)", + "output": "Undefined patient education and/or counseling narrative required (Patient counseling education)" + }, + { + "input": "Definition: CONGENITAL ANOMALIES OF THE BILIARY TRACT, GALLBLADDER AND LIVER described as a rare congenital disorder characterized by cystic dilatation of the intrahepatic bile ducts. It is associated with cholangitis and the formation of stones.\nConcepts: lysine-ketoglutarate reductase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tonychodystrophy was noted (Degenerative disorder)\tOcular dyssynergia (Ataxia)\tCaroli's Disease (Caroli Disease)\tspreading cortical depression (Neurophysiology - biologic function)", + "output": "Caroli's Disease (Caroli Disease)" + }, + { + "input": "Definition: ERT Functional Test Question described as emotion Recognition Test (ERT) Number of surprise stimuli responded to as anger.\nConcepts: Disease Response Assessment Date (Temporal Concept)\tNotophthalmus (Pleurodelinae)\t2-aminobenzoate-coenzyme A ligase activity (CoA-ligase activity)\tEMO113A (Intellectual Product)\tIonisation-chamber radiation survey meter (Device associated with batteries)", + "output": "EMO113A (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as a nanoparticle delivery system for recombinant human tumor necrosis factor (TNF) consisting of recombinant TNF bound to pegylated colloidal gold nanoparticles with potential antineoplastic activity. Upon intravenous administration, colloidal gold-bound recombinant human TNF travels through the bloodstream, avoiding immune detection and uptake by the reticuloendothelial system because of nanoparticle pegylation. Due to their size, the colloidal gold nanoparticles exit the circulatory system only at hyperpermeable tumor neovasculature sites; TNF then binds to and activates tumor cell TNF receptors, which may result in an increase in tumor cell apoptosis and a reduction in tumor cell proliferation. Compared to the administration of unbound TNF, colloidal gold-bound TNF may improve the efficacy and safety of TNF administration by delivering TNF specifically to tumor tissue. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62538\" active clinical trials using this agent.\nConcepts: LEC-5 Standard Version - Unwanted Sex Experience: Learned (Intellectual Product)\tMediastinoscopy, NOS (Endoscopy)\tWBC morphology - myelocyte count (White Blood Cell Count procedure)\tcolloidal gold-bound recombinant human tumor necrosis factor (Amino Acid, Peptide, or Protein)\tAir filter (PROBES, SOUNDS, BOUGIES AND AIRWAYS)", + "output": "colloidal gold-bound recombinant human tumor necrosis factor (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Language described as an Indo-Aryan language belonging to the Indo-European family of languages that is spoken along the western coast of India.\nConcepts: Imatinib Regimen (Regimen Used to Treat Melanoma)\tReproductive System Findings Time Point Reference (Reference Time Point)\tgraft-versus-tumor (Pathologic Processes)\tCDK4 Gene Amplification (Gene Amplification Abnormality)\tKonkani language (Language)", + "output": "Konkani language (Language)" + }, + { + "input": "Definition: Population Group described as organization or person that is permitted to market a medicinal product in a jurisdiction.\nConcepts: CTCAE Grade 1 IVC vein-injury (Injury To Inferior Vena Cava, CTCAE)\tmarketing authorization holder (Governmental or Regulatory Activity)\tPeripheral ICC (Neoplastic Process)\tSciences, Forensic (Occupation or Discipline)\tintegral component of Golgi trans cisterna membrane (integral component of Golgi membrane)", + "output": "marketing authorization holder (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Anemia described as a form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements.\nConcepts: ANEMIA, APLASTIC (Aplastic Anemia)\tHave Headaches (Intellectual Product)\tREAGENT, THROMBOPLASTIN AND CONTROL (Medical Device)\tLack of Adrenarche (Finding)\tRegurgitation;aortic (Aortic valve disorder)", + "output": "ANEMIA, APLASTIC (Aplastic Anemia)" + }, + { + "input": "Definition: Protein deposition described as condition characterized by a dry, waxy type of swelling with abnormal deposits of mucin in the skin and other tissues; it is produced by a functional insufficiency of the thyroid gland, resulting in deficiency of thyroid hormone.\nConcepts: Topical Oil Dosage Form (Biomedical or Dental Material)\tcataract; eye disease (Cataract finding)\tADL03-Appliance: Dryer (ADCS-ADL MCI Questionnaire Question)\tHypothyroidism/myxedema (Diagnosis/Diseases Component)\tAir Embolisms (Embolism)", + "output": "Hypothyroidism/myxedema (Diagnosis/Diseases Component)" + }, + { + "input": "Definition: Findings-Based Question described as a question about an individual's change in bowel pattern at its worst.\nConcepts: Subcortical Gliosis of Neumann (Hereditary disorder of nervous system)\tVLDLR binding (lipoprotein particle receptor binding)\tNPI1A07 (NPI Questionnaire Question)\tChange in Bowel Pattern at its Worst (Findings-Based Question)\tDigestive Diseases (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision)", + "output": "Change in Bowel Pattern at its Worst (Findings-Based Question)" + }, + { + "input": "Definition: something described as research on cancer survivors, covers the full spectrum of biomedical and psycho-social issues that arise at the point of discontinuation of cancer-specific therapy to the point of terminal diagnosis (6 months or less to live).\nConcepts: GLOVE, PATIENT EXAMINATION, VINYL (Medical Device)\tRoman World (Western World)\tCancer Survivorship Research (Research Activity)\tdietary supplements hydrochloric acid preparations (Strong acid)\tCounterbalance Device (Manufactured Object)", + "output": "Cancer Survivorship Research (Research Activity)" + }, + { + "input": "Definition: ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory - Check all that were used: food processor.\nConcepts: Prevotella (Bacteroidaceae)\tADCS-ADL - Appliance: Food Processor (Intellectual Product)\tBook Reviews (Intellectual Product)\tPHOSPHOTRANSFERASES PHOSPHOMUTASES (Amino Acid, Peptide, or Protein)\tReverse Three Hybrid System Techniques (Molecular Biology Research Technique)", + "output": "ADCS-ADL - Appliance: Food Processor (Intellectual Product)" + }, + { + "input": "Definition: Ophthalmic Anti-allergy Agents described as the tromethamide salt form of lodoxamide, a synthetic mast cell stabilizing compound with anti-inflammatory activity. Upon administration to the eye, lodoxamide tromethamide inhibits type I immediate hypersensitivity reaction by preventing the antigen-stimulated calcium influx into mast cells, thereby inhibiting release of histamine. Lodoxamide tromethamide also prevents the release of slow-reacting substances of anaphylaxis (SRS-A) and inhibits eosinophil chemotaxis.\nConcepts: protein tyrosine kinase inhibitor activity (protein kinase inhibitor activity)\tOtter (Mammal)\tSY Term Type (Term Type)\tAlpha-1 Microglobulin (Immunologic Tests)\tophthalmologicals anti-inflammatory lodoxamide tromethamine (lodoxamide)", + "output": "ophthalmologicals anti-inflammatory lodoxamide tromethamine (lodoxamide)" + }, + { + "input": "Definition: something described as any form of anemia that results from the absence of, or the defective action of, any enzyme involved in erythropoiesis.\nConcepts: Subcutaneous lipoma (Mass of subcutaneous tissue)\tHLA-A*2402-restricted URLC10 peptides vaccine (Amino Acid, Peptide, or Protein)\tAntiaris, NOS (Moraceae)\t7S RNA binding (Genetic Function)\tAnemia due to Erythrocyte Enzyme Disorder (Disease or Syndrome)", + "output": "Anemia due to Erythrocyte Enzyme Disorder (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.\nConcepts: Childhood Rickets (Disease or Syndrome)\tLung Cancer cM1 TNM Finding v8 (Lung Cancer Clinical Distant Metastasis TNM Finding v8)\tTumor Associated Differentially Expressed Gene 15 Protein (Serine Proteases)\tvincristine liposomal (V [Preparations])\tProgesterone Receptor Positive by Immunohistochemistry 91-100 Percent (Progesterone Receptor Positive by Immunohistochemistry)", + "output": "vincristine liposomal (V [Preparations])" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs that bind to but do not activate SEROTONIN 5-HT1 RECEPTORS, thereby blocking the actions of SEROTONIN 5-HT1 RECEPTOR AGONISTS. Included under this heading are antagonists for one or more of the specific 5-HT1 receptor subtypes.\nConcepts: Antagonists, 5-HT1 (Pharmacologic Substance)\tSIALIC ACID-BINDING IMMUNOGLOBULIN-LIKE LECTIN 9 (Gene or Genome)\tscavenger receptor binding (signaling receptor binding)\tErchoniaVP ea.15min (Mechanical Treatments)\tIVD Test Reagent/Kits, Immunoassay, Immunology, Cytokine, Colony Stimulating Factor (Medical Device)", + "output": "Antagonists, 5-HT1 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a measurement of the Felis catus dander antigen IgG4 antibody in a biological specimen.\nConcepts: Muscle-Specific Enhancer Factor-2A (Amino Acid, Peptide, or Protein)\tGTPase Regulator Associated With the Focal Adhesion Kinase pp125 Gene (Gene or Genome)\tSCOPOLAMINE (Scopolamine Derivatives)\tToxins In Children (Finding)\tCat Dander Antigen IgG4 Antibody Measurement (Laboratory Procedure)", + "output": "Cat Dander Antigen IgG4 Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: LAMP3 Gene described as human LAMP3 wild-type allele is located within 3q26.3-q27 and is approximately 41 kb in length. This allele, which encodes lysosome-associated membrane glycoprotein 3 protein, is involved in the regulation of antigen capture, differentiation, and the induction of T-cell responses.\nConcepts: membrane raft organisation (Cell Function)\tintersex (Organism Attribute)\tTSC403 (Gene or Genome)\tSegawa's Disease (Disease or Syndrome)\tSoftware, Workstation Management, Clinical Chemistry/Immunoassay Analyzer (Software, Workstation Management)", + "output": "TSC403 (Gene or Genome)" + }, + { + "input": "Definition: something described as a unique symbol that establishes identity of the material.\nConcepts: Sarcoplasmic Reticulums (Intracellular Membranes)\tcounseling service (Health Care Activity)\tleaflet formation (anatomical structure formation involved in morphogenesis)\tSolid Carbon Dioxide Transport Containers (Transport Containers, Thermal Protection)\tMaterial Identifier with Attribute Identifier (Identifier)", + "output": "Material Identifier with Attribute Identifier (Identifier)" + }, + { + "input": "Definition: Positive Regulation of Apoptosis described as any process that activates or increases the frequency, rate or extent of anoikis.\nConcepts: Malignant Tumor of Pulmonary Vein (Malignant neoplasm of great vessels)\tUHDR133A (UHDRS 1999 Version Clinical Classification Question)\tanomaly; connection, pulmonary veins, partial (CONGENITAL ANOMALIES OF THE PULMONARY VESSELS)\tAbnormal muscle fiber protein expression (Anatomical Abnormality)\tpositive regulation of anoikis (Positive Regulation of Apoptosis)", + "output": "positive regulation of anoikis (Positive Regulation of Apoptosis)" + }, + { + "input": "Definition: Missense Mutation described as a point mutation in the FLT3 gene that encodes an amino acid substitution in the receptor-type tyrosine-protein kinase FLT3 protein.\nConcepts: supersaturated calcium phosphate rinse (Inorganic Chemical)\tExercise-induced muscle cramping (MUSCLE SOFT, TISSUE)\tCARTOX Grade 3 (Intellectual Product)\tpreoptico-hypothalamic area (THALAMUS, HYPOTHALAMUS AND EPITHALAMUS)\tFLT3 Missense Mutation (FLT3 Gene Mutation)", + "output": "FLT3 Missense Mutation (FLT3 Gene Mutation)" + }, + { + "input": "Definition: something described as an antibody that recognizes a tumor-associated antigen (TAA) and is induced and expressed following immunization by a therapeutic antibody targeting the same TAA.\nConcepts: Ab3 Prime (Immunologic Factor)\tmeningitis (Meningitis NEC)\tprickle planar cell polarity protein 1 (Signaling Pathway Gene)\tinsulin processing (Molecular Function)\tQIDSC1 (Clinical Classification)", + "output": "Ab3 Prime (Immunologic Factor)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a semi-solid composed of a soft, smooth mass with relatively thick consistency and strong adhesiveness that becomes solid when dry.\nConcepts: Duodenal Ulcer (Ulceration of intestine)\tPlaster (Solid Dose Form)\tSuperior Transverse Axis (Body Location or Region)\tKRAS CYS-12 Mutant Protein (Amino Acid, Peptide, or Protein)\tP62C MYC (Nuclear Proteins)", + "output": "Plaster (Solid Dose Form)" + }, + { + "input": "Definition: something described as a coded value specifying that an expected reason for something occurring was not the motivation, cause or rationale in this particular case.\nConcepts: locomotion (Movement)\tnonReasonCode (Code)\tCannot Swallow Because it Causes Choking (Intellectual Product)\tCurrent Oral Contraceptive User (CPTAC Responses)\tFamily History of Marfan Syndrome (Finding)", + "output": "nonReasonCode (Code)" + }, + { + "input": "Definition: Intellectual Product described as extended Glasgow Outcome Scale (GOSE) What is the most important factor in outcome?\nConcepts: negative regulation of T-helper 17 type immune response (regulation of T-helper 17 type immune response)\tStage III Thyroid Gland Follicular Carcinoma AJCC v8 (Stage III Differentiated Thyroid Gland Carcinoma AJCC v8)\tStage III Nasal Cavity and Paranasal Sinus Cancer AJCC v6 (Nasal Cavity and Paranasal Sinus Cancer by AJCC v6 Stage)\tRefractory EBV-Positive Diffuse Large B-Cell Lymphoma, NOS (Diffuse large B-cell lymphoma refractory)\tGOSE1-Most Important Factor in Outcome (GOSE Questionnaire Question)", + "output": "GOSE1-Most Important Factor in Outcome (GOSE Questionnaire Question)" + }, + { + "input": "Definition: Disease or Syndrome described as duplication of the short arm of chromosome 2 with psychomotor retardation, characteristic facies (prominent forehead, frontal upsweep of hair, hypertelorism, micrognathia, and nose and ear malformations), narrow palate, dolichostenomelia, finger and toe abnormalities, and genital anomalies. Less frequently occurring abnormalities include neural tube defects anencephaly, encephalocele, and spina bifida), bronchial and pulmonary hypoplasia, diaphragmatic hernia, neuroblastoma, a genital anomalies, and congenital heart defects.\nConcepts: Alphapapillomavirus 10 (Virus)\tData Table (Intellectual Product)\tMARRIED (MaritalStatus - CodeSystem)\tchromosome 2p duplication syndrome (Disease or Syndrome)\tOXYTOCIN (Pharmacologic Substance)", + "output": "chromosome 2p duplication syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Acetanilides described as anthelmintic. It has been shown to be useful in fasciola infections in sheep.\nConcepts: Oropharyngeal Cancer pN0 TNM Finding v6 (Finding)\tBanks, Seed (Plant)\tExercise-induced fatigue (Feeling tired)\tDRRI1-O: People Made Me Feel Proud (Intellectual Product)\tDiamfenetide (Anthelmintics)", + "output": "Diamfenetide (Anthelmintics)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a preparation of genetically modified, multi-antigen-directed autologous T-lymphocytes, that have particles, consisting of multiple chemically crosslinked human cytokine interleukin-15 (IL-15)/IL-15 receptor alpha (IL-15Ra)/Fc heterodimers, attached to their surface, with potential immunostimulating and antineoplastic activities. TRQ15-01 is made from monocyte-derived dendritic cells (moDCs) that are pulsed with peptides from multiple tumor-associated antigens (TAAs) to expand cytotoxic T-lymphocytes (CTLs) that are subsequently loaded with IL-15 particles. Upon administration of the autologous deep IL-15 primed T-cells, the IL-15/IL-15Ra fusion proteins are slowly released in vivo from the T-cells in a controlled manner and induce autocrine cytokine stimulation of the administered T-cells, thereby increasing T-cell division of the administered T-cells. The expanded T-cells target, bind to and kill tumor cells. This increases tumor cell growth inhibition by T-cells. IL-15 is a pro-survival, inflammatory cytokine and causes sustained T-cell expansion and enhanced anti-tumor activity. Compared to systemically delivered IL-15, IL-15 attached to the T-cells greatly increases target CD8 T-cell concentrations in the tumor, without significant systemic effects.\nConcepts: Blood vitamin B6 analysis (Laboratory Procedure)\tNeuroepithelioma NOS (Embryonal Neoplasm)\tAutologous Deep IL-15 Primed T-cells TRQ15-01 (Cell)\tlabor stage first (Labor)\tAbnormality of the metencephalon (Anatomical Abnormality)", + "output": "Autologous Deep IL-15 Primed T-cells TRQ15-01 (Cell)" + }, + { + "input": "Definition: Substance type described as garbage, refuse, or sludge, or other discarded materials from a wastewater treatment plant, water supply treatment plant, and air pollution control facility that include solid, semi-solid, or contained material. It does not include materials dissolved in domestic sewage, irrigation return flows, or industrial discharges.\nConcepts: regulation of citrulline biosynthetic process (Molecular Function)\tWaste, Solid (Waste Products)\tStage IV AIDS-Related Anal Canal Carcinoma AJCC v6 and v7 (AIDS-Related Anal Canal Carcinoma)\tFamily Size (Group Attribute)\tpancreatic D cell development (Cell Function)", + "output": "Waste, Solid (Waste Products)" + }, + { + "input": "Definition: Neoplastic Process described as aleukemic leukemia cutis where the skin in infiltrated by lymphoblasts.\nConcepts: disorder of lacrimal system (disorder of eyelid or lacrimal system)\tAleukemic Acute Lymphoblastic Leukemia Cutis (Cutaneous Precursor Lymphoid Neoplasm)\tAlbumins (Amino Acid, Peptide, or Protein)\tFAC10038 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tFT-ERT TEST (Intellectual Product)", + "output": "Aleukemic Acute Lymphoblastic Leukemia Cutis (Cutaneous Precursor Lymphoid Neoplasm)" + }, + { + "input": "Definition: something described as single celled eukaryotic organisms having plant, animal, or fungal characteristics; have highly developed cell organelles; freeliving; heterotrophic, autotrophic, and saprophytic; terrestrial or aquatic.\nConcepts: Protista (Eukaryota)\tphenylacrylic acid ester biosynthetic process (Molecular Function)\tHrd1p ubiquitin ligase complex (Cell Component)\tLHRH (Gene or Genome)\tHIV-Lipodystrophy (Neoplastic Process)", + "output": "Protista (Eukaryota)" + }, + { + "input": "Definition: Theatre described as a composition in prose or verse presenting in dialogue or pantomime a story involving various characters, usually intended to be acted on a stage and to be regarded as a form of entertainment.\nConcepts: Adamantinoma (Primary malignant neoplasm of bone)\tpeptidyl-arginine C-methylation (Molecular Function)\tplay (Theatre)\tleptandra virginica/veronica (Pharmacologic Substance)\tProduct containing binimetinib (Pharmacologic Substance)", + "output": "play (Theatre)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the initial segment of a nerve leaving the cervical spine. There are eight pairs of cervical roots, each consisting of two parts: the ventral (efferent motor) and the dorsal (afferent sensory) root which unite to form a single spinal nerve. All cervical nerves exit superiorly to their corresponding vertebrae with the exception of C8, which exits inferiorly to the C7 vertebra.\nConcepts: HTR1C (Gene or Genome)\tcervical nerve root (Peripheral nerve structure of trunk)\tFood, Drugs, and Medical Devices Regulatory Document (Intellectual Product)\tSafety Scalpels (Medical Device)\tFour (Quantitative Concept)", + "output": "cervical nerve root (Peripheral nerve structure of trunk)" + }, + { + "input": "Definition: Male reproductive function described as the developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.\nConcepts: KRAS Protein Variant (Cell or Molecular Dysfunction)\tspermatogeny (male gamete generation)\tEchoviruses (Virus)\tergosta-5,22-dien-3 beta-ol (phytosterols)\tBcl-2-Like Protein 2 (Biologically Active Substance)", + "output": "spermatogeny (male gamete generation)" + }, + { + "input": "Definition: Obstetric procedure described as physiologic or biochemical monitoring of the fetus. It is usually done during LABOR, OBSTETRIC and may be performed in conjunction with the monitoring of uterine activity. It may also be performed prenatally as when the mother is undergoing surgery.\nConcepts: Monitoring;fetal (Foetal and neonatal diagnostic procedures)\tApolizumab (Monoclonal Antibodies)\tAnal Carcinoma pT2 TNM Finding v8 (Anal Cancer Pathologic Primary Tumor TNM Finding v8)\tPhilippine; hemorrhagic fever (Dengue Fever)\tDefinitely as Much (Clinical or Research Assessment Answer)", + "output": "Monitoring;fetal (Foetal and neonatal diagnostic procedures)" + }, + { + "input": "Definition: Rectal Dosage Form described as liquid preparation consisting of a suspension intended for rectal use or for diagnostic purposes. Rectal suspension are usually presented in containers with a volume in the range of 2.5 mL to 2000 mL. The container is fitted with an applicator or an applicator is provided separately.\nConcepts: Rectal Suspension (Rectal Dosage Form)\tregulation of calcium ion-dependent exocytosis of neurotransmitter (Cell Function)\treligious organization (Organized religion)\tGrade 2 Immune System Disorders - Other, Specify, CTCAE (Finding)\tStage IIIC Testicular Cancer AJCC v8 (Stage III Testicular Cancer AJCC v8)", + "output": "Rectal Suspension (Rectal Dosage Form)" + }, + { + "input": "Definition: Aerobic-microaerophilic, motile curved gram-negative bacteria described as any bacterial organism that is not assigned to the species level but can be assigned to the Spirillum genus level.\nConcepts: Spirillum species (BACTERIA AND RICKETTSIAE)\tPT2977 (Antineoplastic Agents)\tCatatonic Schizophrenias (Psychological Disorders)\tEthylaldehyde (Organic Chemical)\tPituitary adenoma, no ICD-O subtype (Benign neoplasm of pituitary gland)", + "output": "Spirillum species (BACTERIA AND RICKETTSIAE)" + }, + { + "input": "Definition: Blood Proteins described as any of the lipid-protein complexes in which lipids are transported in the blood; lipoprotein particles consist of a spherical hydrophobic core of triglycerides or cholesteryl esters surrounded by an amphipathic monolayer of phospholipids, cholesterol, and apolipoproteins.\nConcepts: Completely Interferes (Clinical or Research Assessment Answer)\tTeaching: Infant Safety 10-12 Months (Educational Activity)\tblood lipoprotein (Blood Proteins)\tC-SSRS Already Enrolled Subjects - Non-Specific Active Suicidal Thoughts (Intellectual Product)\tclearance of foreign intracellular nucleic acids (Cell Function)", + "output": "blood lipoprotein (Blood Proteins)" + }, + { + "input": "Definition: something described as a member of the I kappa B family, B-cell lymphoma 3-encoded (bcl-3) protein is involved in the regulation of TRANSCRIPTIONAL ACTIVATION of NF-KAPPA B target genes.\nConcepts: GAUGE, MEASURING (Medical Device)\tANTIGEN, HA (INCLUDING HA CONTROL), MUMPS VIRUS (Indicator, Reagent, or Diagnostic Aid)\tKoumiss (Milk)\tBCL 3 Protein (Amino Acid, Peptide, or Protein)\tCD30L Receptor (Immunologic Factor)", + "output": "BCL 3 Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Hemosiderin pigmentation described as accumulation of iron in internal organs.\nConcepts: HAEMOSIDEROSIS (Disease or Syndrome)\tCSS0503C (C-SSRS Already Enrolled Subjects Questionnaire Question)\tPF24RT24 Plasma (Pharmacologic Substance)\tBenign Mucinous Cystadenoma of the Ovary (Adenoma)\tcentral depressants nervous system (Pharmacologic Substance)", + "output": "HAEMOSIDEROSIS (Disease or Syndrome)" + }, + { + "input": "Definition: VFQ25-Interviewer Administered Format Questionnaire Question described as visual Functioning Questionnaire 25-Interviewer Administered Format Version 2000 (VFQ25-Interviewer Administered Format) Difficulty With Activities: How much difficulty do you have driving at night? Would you say you have:\nConcepts: transepithelial L-ascorbic acid transport (vitamin transport)\tpICln-Sm protein complex location (Sm-like protein family complex)\tPlatelet-Activating Factor Acetylhydrolase Deficiency (Disease or Syndrome)\tmalolactic enzyme activity (Molecular Function)\tVFQ116 (Intellectual Product)", + "output": "VFQ116 (Intellectual Product)" + }, + { + "input": "Definition: something described as an antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells.\nConcepts: acetyl-CoA:L-lysine N6-acetyltransferase (Molecular Function)\tt(4;11)(q21;q23) (Cell or Molecular Dysfunction)\tallocolchicine (Colchicine-Site Binding Agent)\tIL-13R (Cytokine Receptor Gene)\tSimulators, Environmental Detector/Monitor, Ionizing Radiation, Alpha/Beta (Simulators, Environmental Detector/Monitor, Ionizing Radiation)", + "output": "allocolchicine (Colchicine-Site Binding Agent)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant neoplasm arising in an anatomic site exposed to solar radiation.\nConcepts: Radioembolization (selective internal radiation therapy)\tC-SSRS Already Enrolled Subjects - Duration of Most Severe Ideation (C-SSRS Already Enrolled Subjects Questionnaire Question)\tKSP Inhibitor SB-743921 (Pharmacologic Substance)\tSolar Radiation-Related Malignant Neoplasm (Radiation-Induced Cancer)\tTesting, Usability (Intellectual Product)", + "output": "Solar Radiation-Related Malignant Neoplasm (Radiation-Induced Cancer)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders.\nConcepts: Imipramina (Tricyclic compound)\t3 Iodobenzylguanidine, 123I Labeled (Substance categorized by disposition)\tOtitis (Disease or Syndrome)\tMyoneural Junction (Peripheral Nerves)\tRubricyte/Total Cells (Blood Cell Count Ratio Measurement)", + "output": "Imipramina (Tricyclic compound)" + }, + { + "input": "Definition: Free lower limb described as lower extremity from knee to ankle\nConcepts: Structure of lower leg (Body part)\tLeghemoglobin (Globin)\tSyringes, Catheter (Medical Device)\tphase 3b (Research Activity)\tColorectal Region (Body Location or Region)", + "output": "Structure of lower leg (Body part)" + }, + { + "input": "Definition: Products and technology for communication described as equipment, products and technologies used by people in activities of sending and receiving information, such as optical and auditory devices, audio recorders and receivers, television and video equipment, telephone devices, sound transmission systems and face-to-face communication devices, not adapted or specially designed.\nConcepts: Ocular infections (Classification)\tCHESTCIR (Finding)\tmitochondrial pyruvate dehydrogenase complex location (Cell Component)\tGeneral products and technology for communication (Manufactured Object)\teastern schistosomiasis (Schistosomiasis)", + "output": "General products and technology for communication (Manufactured Object)" + }, + { + "input": "Definition: Nursing Assessment Entity described as pain that persists over time\nConcepts: Stachybotrys (Fungus)\tSODIUM BICARBONATE COTRANSPORTER 2 (Gene or Genome)\tChronic pain (Symptomatology)\tDDS01-Subscale 2: Management Distress (Intellectual Product)\tMalignant mediastinal tumour (Mediastinal Diseases)", + "output": "Chronic pain (Symptomatology)" + }, + { + "input": "Definition: RAND Social Support Survey Questionnaire Question described as RAND Social Support Survey Instrument (RAND Social Support Survey) How often is each of the following kinds of support available to you if you need it: Someone who shows you love and affection.\nConcepts: B-Cell Activating Factor (Laboratory Procedure)\tRAND Social Support Survey - Shows You Love and Affection (RAND Social Support Survey Questionnaire Question)\tpneum (Pneumonia)\tMyoneme (Muscle fiber group)\tLimb girdle (Body Part, Organ, or Organ Component)", + "output": "RAND Social Support Survey - Shows You Love and Affection (RAND Social Support Survey Questionnaire Question)" + }, + { + "input": "Definition: Spatial Concept described as spatial association relationship which describes the containment, adjacency and anatomical coordinates of physical anatomical entities. Examples: anatomical containment, anatomical adjacency, anatomical coordinate.\nConcepts: IAP4 (BIRC5 gene)\tPAPERS, ION (Medical Device)\tAnatomical location (Property)\tup-regulation of IL-17 secretion (Cell Function)\tTrifascicular Bundle Branch Block (Conduction disorder of the heart)", + "output": "Anatomical location (Property)" + }, + { + "input": "Definition: Pharyngeal disorders described as inflammation of the throat.\nConcepts: peptidyl-arginine ADP-ribosylation (protein ADP-ribosylation)\tPHARYNGITIS (Upper respiratory tract infections NEC)\tRIIbeta, cAMP Protein Kinase (Enzyme)\tFAC017-I Feel Nervous (FACT-LEU Version 4 Questionnaire Question)\tmulticellular organism adhesion (multicellular organismal process)", + "output": "PHARYNGITIS (Upper respiratory tract infections NEC)" + }, + { + "input": "Definition: something described as an immunohistochemical staining finding indicating that 41-50 percent of the cells in a tissue sample are expressing progesterone receptor.\nConcepts: LUPARTUMAB AMADOTIN (Pharmacologic Substance)\tHave Enough Support and Advice to Make Choice (Intellectual Product)\tProgesterone Receptor Positive by Immunohistochemistry 41-50 Percent (Laboratory or Test Result)\tVALACYCLOVIR (Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor)\tfibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow (fibroblast growth factor receptor signaling pathway)", + "output": "Progesterone Receptor Positive by Immunohistochemistry 41-50 Percent (Laboratory or Test Result)" + }, + { + "input": "Definition: regulation of endothelial cell chemotaxis described as any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor.\nConcepts: flavin reductase (NADH) activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tRetinol-Binding Proteins, Cellular (Biologically Active Substance)\tregulation of endothelial cell chemotaxis to fibroblast growth factor (regulation of endothelial cell chemotaxis)\tLung Cancer Pathologic Distant Metastasis TNM Finding v8 (Finding)\tCharged Slide (Manufactured Object)", + "output": "regulation of endothelial cell chemotaxis to fibroblast growth factor (regulation of endothelial cell chemotaxis)" + }, + { + "input": "Definition: Tissue described as tract of brain, each instance of which is a group of nerve fibers making up the efferent pathways of some hypothalamus, arising from some hypothalamic nuclei and ending at various levels in some median eminence, infundibulum, and neurohypophysis (posterior pituitary).\nConcepts: Hypothalamic-hypophyseal tract (Tissue)\tHas pack size (Intellectual Product)\textracellular ferritin complex location (ferritin complex)\ttoken economy (Rewards)\tUNDERGRAD MED EDUC (Education, Medical)", + "output": "Hypothalamic-hypophyseal tract (Tissue)" + }, + { + "input": "Definition: Needles, Injection, Intravenous described as intravenous injection needles designed for short-term therapeutic infusion of fluids into the scalp veins, other small-diameter peripheral veins, and the veins of pediatric patients. These needles typically include a thin-walled, stainless steel, beveled cannula (18 to 27 gauge is typical), usually 3/4 inches (19 mm) in length, for introduction into the veins; wings that help with the insertion and add protection to inadvertent pullout; and a tube (e.g., 30 cm in length) to be attached to a syringe or other infusion device.\nConcepts: Idiopathic linear interstitial keratitis (Disease or Syndrome)\tArea, Anterior Hypothalamic (Hypothalamus, Anterior)\tScalp vein needle (Cardiovascular equipment)\tNCI CTEP SDC Lung, Mediastinal and Pleural Neoplasm Category Terminology (Intellectual Product)\tArterial pulse pressure, NOS (Thesaurus of Psychological Index Terms)", + "output": "Scalp vein needle (Cardiovascular equipment)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification described as immunohematology reagents available as a two-vial set (i.e., two-cell test) that are used for detection of alloantibodies to red cell antigens. These reagents are group O red blood cells, either from a single source when used in patient testing or from pooled sources when used in donor testing. Red blood cells used for screening must express the antigens associated with the most clinically relevant antibodies, such as those related to the Rh (e.g., C, D, E), Kell, Duffy, and Kidd blood groups.\nConcepts: Assessment (Diagnosis)\tGrade 3 Activated Partial Thromboplastin Time Prolonged, CTCAE (Activated Partial Thromboplastin Time Prolonged, CTCAE)\tIntermittent (Temporal Qualifier)\tMIVOBULIN ISETHIONATE (Pharmacologic Substance)\tIVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Two Cell Screening (Medical Device)", + "output": "IVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Two Cell Screening (Medical Device)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H(+) + lithocholate + NADPH + O(2) = 6-beta-hydroxylithocholate + H(2)O + NADP(+).\nConcepts: Automated Text Message-based Navigation (Other Intervention or Procedure)\tGrade 4 Pneumonitis, CTCAE (Finding)\tlithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity (Molecular Function)\tDENOTIVIR (Antiviral Agents)\tEXACT1TC (CDISC Questionnaire Terminology)", + "output": "lithocholate,NADPH:oxygen oxidoreductase (6beta-hydroxylating) activity (Molecular Function)" + }, + { + "input": "Definition: Nervous System Substances and Factors described as polypeptide proteins that stimulate growth and development of peripheral, sympathetic, and sensory neurons.\nConcepts: Winchester Corn Gallon (Quantitative Concept)\trationale (Idea or Concept)\tFactors, Nerve Growth (Amino Acid, Peptide, or Protein)\tSource Data Verification (Document type)\tHyperglycemia Management (Blood glucose management)", + "output": "Factors, Nerve Growth (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Male internal genital organ described as disturbance of cell integrity and deterioration of germ cells.\nConcepts: butyryl-CoA 2-C-propionyltransferase activity (Molecular Function)\tGerm Cell Degeneration (Male internal genital organ)\tGrade 3 Malaise (Malaise, CTCAE)\tBAGE tumor antigen, human (Amino Acid, Peptide, or Protein)\tApolipoprotein A Measurement (Laboratory Procedure)", + "output": "Germ Cell Degeneration (Male internal genital organ)" + }, + { + "input": "Definition: RNA described as an RNA complex consisting of two base-paired strands of complementary RNA.\nConcepts: Double-Stranded (ds) RNA (PURINES, PYRIMIDINES AND NUCLEIC ACIDS)\t15q26.3 (Cell Component)\tupregulation of transforming growth factor-beta3 production (regulation of transforming growth factor beta3 production)\tLandmark, Anatomic (Body Location or Region)\tMUCOUS MEMBRANE HEMANGIOMA (Finding)", + "output": "Double-Stranded (ds) RNA (PURINES, PYRIMIDINES AND NUCLEIC ACIDS)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a humanized monoclonal antibody directed against the tyrosine kinase receptor colony stimulating factor 1 receptor (CSF1R; CSF-1R; CD115), also known as macrophage colony-stimulating factor receptor (M-CSFR), with potential antineoplastic and immunomodulating activities. Upon administration, emactuzumab binds to CSF1R expressed on macrophages and inhibits the binding of colony-stimulating factor-1 (CSF-1) to CSF1R. This prevents CSF1R activation and CSF1R-mediated signaling in these cells, which blocks the production of inflammatory mediators by macrophages and reduces inflammation. By blocking both the activity of CSF1R-dependent tumor-associated macrophages (TAMs) and the recruitment of TAMs to the tumor microenvironment, emactuzumab enhances T-cell infiltration and antitumor T-cell immune responses, which inhibits the proliferation of tumor cells. TAMs play key roles in immune suppression and promoting inflammation, tumor cell proliferation and survival.\nConcepts: Grade 4 Ventricular fibrillation (Ventricular Fibrillation, CTCAE 5.0)\tAI (Pharmaceutical Preparations)\tEmactuzumab (Immunologic Factor)\tStage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8 (Uterine Corpus Cancer by AJCC v8 Stage)\tIDH2 Gene Mutation (IDH gene mutation)", + "output": "Emactuzumab (Immunologic Factor)" + }, + { + "input": "Definition: Functions and Abnormal Functions of the Oral Cavity described as the loss of tooth structure by mechanical forces from opposing teeth.\nConcepts: Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine (Immunologic Factor)\tup-regulation of tatiopterin anabolism (regulation of tatiopterin biosynthetic process)\taccessory olfactory bulb, mitral layer (Body Part, Organ, or Organ Component)\tAttrition, Tooth (Dental surface disorders)\tCone-shaped end part of the ring finger bones (Abnormality of the epiphyses of the 4th finger)", + "output": "Attrition, Tooth (Dental surface disorders)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis.\nConcepts: positive regulation of astrocyte chemotaxis (regulation of astrocyte chemotaxis)\tMSQOL-54 - Emotional Problem Did Not Do Work Carefully (MSQOL-54 Questionnaire Question)\tdetection of hypoxic conditions in blood by aortic body chemoreceptor signaling (detection of hypoxic conditions in blood by chemoreceptor signaling)\t1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate catabolic process (Molecular Function)\tDocumentaries and Factual Films (Intellectual Product)", + "output": "positive regulation of astrocyte chemotaxis (regulation of astrocyte chemotaxis)" + }, + { + "input": "Definition: Lithium Compounds described as the carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stem cells.\nConcepts: Lithium carbonate preparation (Carbonates)\tplasmodesma-mediated intercellular transport (intercellular transport)\tRivipansel (Organic Chemical)\tectodermal dysplasia-mental retardation-syndactyly syndrome (Disease or Syndrome)\tgeographic difference (Idea or Concept)", + "output": "Lithium carbonate preparation (Carbonates)" + }, + { + "input": "Definition: Neonatal Rash, Adverse Event described as an adverse event in a newborn characterized by localized rash.\nConcepts: DDAT (Date in time)\tcaribbean (Americas)\tColostrums (Milk)\t22: 23153646-23162879 (Chromosome 22 Physical Location)\tGrade 1 Neonatal Rash, AE (Finding)", + "output": "Grade 1 Neonatal Rash, AE (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human ACKR3 wild-type allele is located in the vicinity of 2q37.3 and is approximately 15 kb in length. This allele, which encodes atypical chemokine receptor 3 protein, plays a role in the modulation of chemokine signal transduction pathways. Translocations involving the gene and the human HMGA2 gene are associated with lipoma.\nConcepts: Powder for conventional release nebulizer suspension (Powder for reconstitution for drug product)\tAtypical Chemokine Receptor 3 wt Allele (Gene or Genome)\tfludarabine-5'-monophosphate (fludarabine)\tCervical Carcinoma pT3b TNM Finding v8 (Cervical Cancer pT3 TNM Finding v8)\tstage IIIA testicular cancer (stage III testicular cancer)", + "output": "Atypical Chemokine Receptor 3 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Pathologic Function described as an infant born after 28 completed weeks of gestation and before 32 completed weeks of gestation.\nConcepts: Methanesulfon-m-anisidide, 4'-(9-acridinylamino)-, compd. with Lactic Acid (Acridine)\tAdenocarcinoma In Situ in Villous Adenoma (Adenocarcinoma in situ in adenomatous polyp)\tBorn very premature (Pathologic Function)\tPempidine (Pharmacologic Substance)\tPepsinum / digestive enzyme (Enzyme)", + "output": "Born very premature (Pathologic Function)" + }, + { + "input": "Definition: Foods, Specialized described as food and dietary formulations including elemental (chemically defined formula) diets, synthetic and semisynthetic diets, space diets, weight-reduction formulas, tube-feeding diets, complete liquid diets, and supplemental liquid and solid diets.\nConcepts: Formulated Foods (Foods, Specialized)\tMyricetin (Pharmacologic Substance)\tup regulation of serotonin uptake (regulation of serotonin uptake)\tcongenital absence of kidney (Congenital absence)\tsodium/hydrogen antiporter activity (sodium ion transmembrane transporter activity)", + "output": "Formulated Foods (Foods, Specialized)" + }, + { + "input": "Definition: Software, Physiologic Monitoring described as physiologic monitoring software designed to operate intracranial pressure monitors, control/monitor a limited number of their functions, and/or process data obtained while monitoring. This software is intended to work only with one or a few models of intracranial pressure monitors, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements performed while monitoring intracranial pressure and/or while processing and/or transmitting/receiving patient information from workstations, and/or hospital information systems. Intracranial pressure monitoring software is not usually available separate from the monitor but may be updated (i.e., through the release of modified versions) during the life of the equipment; the software is mainly used by bedside and telemetric monitors, and/or physiologic monitoring systems.\nConcepts: HAMD4-Social Life Activities/Interests (HAM-D6 Clinician Version Clinical Classification Question)\tSoftware, Physiologic Monitoring, Intracranial Pressure (Intellectual Product)\tplasma cell leukemia (Multiple myeloma and malignant plasma cell neoplasms)\tregulation of slow-twitch skeletal muscle contraction (regulation of twitch skeletal muscle contraction)\tregulation of adipose tissue development (Biologic Function)", + "output": "Software, Physiologic Monitoring, Intracranial Pressure (Intellectual Product)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) Taking everything into consideration, during the past week how satisfied have you been with your: economic status?\nConcepts: chlorophyll anabolism (pigment biosynthetic process)\tQLES1-Economic Status (Q-LES-Q Questionnaire Question)\tParacoccus yeei corrig. Daneshvar et al. 2003 (Paracoccus bacteria)\ttransferrin receptor 2 (Gene or Genome)\tCARNEY SYNDROME (Lentigo simplex)", + "output": "QLES1-Economic Status (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: Vascular hypotensive disorders described as a condition in which there is neurologic degeneration, postural tachycardia, and muscular rigidity.\nConcepts: RAVULIZUMAB (Selective immunosuppressants)\tadenylyl-L-glutamate:ammonia ligase (ADP-forming) adenylylhydrolase activity (Molecular Function)\tRetinal artery, NOS (EYES AND EYE APPENDAGES)\tMultisystemic Atrophy (Vascular hypotensive disorders)\tpositive regulation of peptidolysis (Molecular Function)", + "output": "Multisystemic Atrophy (Vascular hypotensive disorders)" + }, + { + "input": "Definition: Finding described as pelvic rotation about a transverse (horizontal) axis (forward or backward tilt) or about an anterior-posterior axis (right or left side tilt).\nConcepts: Mimae Infection (Bacterial infections NEC)\tregulation of epidermal development (Organ or Tissue Function)\tRegulatory Protein E2 (Papillomavirus Protein E2)\tPelvic Declination (Finding of bone of pelvis)\tMetaphase (Metaphase)", + "output": "Pelvic Declination (Finding of bone of pelvis)" + }, + { + "input": "Definition: something described as a valve designed to control the flow of air to a carburetor or a coil in an electronic circuit that passes direct current and attenuates alternating current.\nConcepts: Choke Device (Medical Device)\tMIP1B (CCL4 gene)\tE2F Transcription Factor 6 (Biologically Active Substance)\tTRICHOTHIODYSTROPHY 4, NONPHOTOSENSITIVE (Disease or Syndrome)\tVacuum Funnels (Medical Device)", + "output": "Choke Device (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as the Glucose Monitoring System Satisfaction Survey Version: Type 1 Diabetes - My current monitor: Makes me feel more frustrated with my diabetes.\nConcepts: GMSS Version Type 1 Diabetes - More Frustrated With My Diabetes (GMSS Version Type 1 Diabetes Questionnaire Question)\tCPS01-Ascites (Intellectual Product)\tTesticular Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma (Testicular germ cell tumor mixed)\tEGFR delta V834 (EGFR Protein Variant)\tVirus, H7N2 (Influenza A virus subtype H7)", + "output": "GMSS Version Type 1 Diabetes - More Frustrated With My Diabetes (GMSS Version Type 1 Diabetes Questionnaire Question)" + }, + { + "input": "Definition: Calcium Metabolism Disorders described as a condition characterized by the insensitivity of the tissues to respond to the activity of the parathyroid hormone. It results in increased levels of parathyroid hormone in the serum, hypocalcemia, and hyperphosphatemia.\nConcepts: dendritic Herpes simplex keratitis (Viral keratitis)\tPseudohypoparathyroidism, NOS (Non-Neoplastic Endocrine Disorder)\tDispositions and intra-personal functions (Global mental functions)\tLIVER-SPECIFIC TRANSPORTER 1 (Transport Protein Gene)\tAir Traffic Control (Career Areas)", + "output": "Pseudohypoparathyroidism, NOS (Non-Neoplastic Endocrine Disorder)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Lymphoma Version 4 (FACT-LYM Version 4) Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family.\nConcepts: Lien migrans (Splenic Diseases)\t10E6 Organisms/mg (Unit of Arbitrary Substance Concentration)\tFACT-LYM Version 4 - Trouble Meeting Needs of Family (Intellectual Product)\tType V Secretion System (Bacterial Secretion Systems)\tmetanephric comma-shaped body morphogenesis (Organ or Tissue Function)", + "output": "FACT-LYM Version 4 - Trouble Meeting Needs of Family (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as porphyrins with four methyl and two propionic acid side chains attached to the pyrrole rings.\nConcepts: Ruppia (Plant)\tS Wave Amplitude, Single Beat (ECG Measurement)\tIodine I 123 Anti-CEA Recombinant Diabody T84.66 (Amino Acid, Peptide, or Protein)\tDeuteroporphyrins (Porphyrins)\tDeformed Pupils (examination of pupils)", + "output": "Deuteroporphyrins (Porphyrins)" + }, + { + "input": "Definition: something described as a unit of enzyme concentration which is defined as the amount of enzyme that can digest urea-denatured hemoglobin at the same initial rate as one milliequivalent of tyrosine at standard conditions.\nConcepts: Aldoximes (Organic Chemical)\tAnti-CD20-engineered Toxin Body MT-3724 (Pharmacologic Substance)\tLeishmania chagasi Cunha and Chagas 1937 (Trypanosomatina)\tAnson Unit (Quantitative Concept)\tSGRQ-C - Description of Your Respiratory Problems (Intellectual Product)", + "output": "Anson Unit (Quantitative Concept)" + }, + { + "input": "Definition: Physiologic Function described as any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response.\nConcepts: Arteriosclerosis coronary artery (Atherosclerosis)\tdownregulation of tolerance induction dependent upon immune response (Physiologic Function)\tProgressive distal muscular atrophy (Disease or Syndrome)\tFocal Podocyte Injury (Physical shape)\tFarletuzumab (Immunologic Factor)", + "output": "downregulation of tolerance induction dependent upon immune response (Physiologic Function)" + }, + { + "input": "Definition: something described as adapters designed to couple a video camera to a power and/or video signal source. These adapters typically consist of a cable (e.g., a dedicated coaxial cable) with appropriate connectors at each end that make possible electrical and mechanical matching between one or more particular types of video cameras to a given power and/or video source. The cable usually transmits, in addition to the DC power, video and/or synchronism signals between the camera and the adapter.\nConcepts: Adapters, Power Supply/Video Camera (Medical Device)\tPPO (Managed Care Programs)\tadult diffuse small cleaved cell lymphoma, relapsed (Adult Diffuse Small Cleaved Cell Lymphoma)\tCM-4620 (Immunologic Factor)\t6-phosphofructokinase complex location (transferase complex, transferring phosphorus-containing groups)", + "output": "Adapters, Power Supply/Video Camera (Medical Device)" + }, + { + "input": "Definition: Psychotropic Drugs described as a type of drug that is used to treat depression. Selective serotonin reuptake inhibitors slow the process by which serotonin (a substance that nerves use to send messages to one another) is reused by nerve cells that make it. This increases the amount of serotonin available for stimulating other nerves.\nConcepts: Protein, Organized by Origin (Proteins)\tGerman shepherd dog (Mammal)\tReceptors, Pulmonary Stretch (Stretch Receptors)\tSelect. serotonin re-up inhib (Medicinal product categorized by disposition)\tSport Performance (Individual Behavior)", + "output": "Select. serotonin re-up inhib (Medicinal product categorized by disposition)" + }, + { + "input": "Definition: Histiocytic and Dendritic Cell Neoplasm described as a very rare, multisystem non-Langerhans cell histiocytosis that predominantly affects adults. It is characterized by the proliferation in the tissues of lipid-laden macrophages and the presence of multinucleated giant cells. It results in sclerosis of the long bones and failure of the affected organs. Patients may present with bone pain, exophthalmos, ataxia, liver failure, kidney failure, and hypopituitarism.\nConcepts: doxaminol (Adrenergic beta-Agonists)\tECD (Histiocytic syndrome)\tSTATIST DISTRIBUTIONS (Statistics as Topic)\t3 Plus Score (CDC Mycobacterium Quantitation Scheme)\tMicrocolon (gastrointestinal)", + "output": "ECD (Histiocytic syndrome)" + }, + { + "input": "Definition: something described as nonsyndromic mental retardation with large ears, strabismus, nystagmus, and hypotelorism.\nConcepts: Liquid Oxygen Containers (Medical Device)\tWater Channels (Biologically Active Substance)\tapolipoprotein C1 (Gene or Genome)\tcarbophenothion (Pesticides)\tX-linked mental retardation 11 (Disease or Syndrome)", + "output": "X-linked mental retardation 11 (Disease or Syndrome)" + }, + { + "input": "Definition: Organic Chemical described as the R-isomer of albuterol.\nConcepts: neonatal development (Phenomenon or Process)\tbiphenyl-2,3-diol 1,2-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tUreteric anastomotic leak (Injury, Poisoning and Procedural Complications, CTCAE)\t(-)-Albuterol (Ethanolamine and ethanolamine derivative)\tSuperficial parotidectomy (Partial parotidectomy)", + "output": "(-)-Albuterol (Ethanolamine and ethanolamine derivative)" + }, + { + "input": "Definition: Cyclin-Dependent Kinase Inhibitor Gene described as this gene is involved in cell cycle regulation and arrest.\nConcepts: female urethra (Body Part, Organ, or Organ Component)\tSpinal Osteochondrosis (Korean Standard Classification of Disease Version 5)\ttemporal loop (Body Part, Organ, or Organ Component)\t5'-adenylyl sulfate transmembrane transporter activity (Molecular Function)\tTP15 (Cyclin-Dependent Kinase Inhibitor Gene)", + "output": "TP15 (Cyclin-Dependent Kinase Inhibitor Gene)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking (faster than your usual speed) for 50 steps without stopping. Please indicate why you did not do this in the past 7 days.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Fast 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tESS01-Sitting Quietly After Lunch (Intellectual Product)\tNotched R Wave (R Wave Abnormality by ECG Finding)\t2ND DIAG (Coronary artery)\tPUL 1.2 - Preferred Arm (Intellectual Product)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Fast 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Biologically Active Substance described as bile acid, usually conjugated with either glycine or taurine; acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine.\nConcepts: Irritable (Finding)\tpharmaceutical product (Agent)\tChenodeoxycholate (Pharmacologic Substance)\ta spade hand was noted (Hand)\tLuminal A Prostate Cancer (Neoplastic Process)", + "output": "Chenodeoxycholate (Pharmacologic Substance)" + }, + { + "input": "Definition: Structure of wall of abdominal proper segment of trunk described as the outer margins of the ABDOMEN, extending from the osteocartilaginous thoracic cage to the PELVIS. Though its major part is muscular, the abdominal wall consists of at least seven layers: the SKIN, subcutaneous fat, deep FASCIA; ABDOMINAL MUSCLES, transversalis fascia, extraperitoneal fat, and the parietal PERITONEUM.\nConcepts: Nervous System Injury (nervous system disorder)\tVascularis, Stria (Spiral Ligament of Cochlea)\tOutcomes, Fatal (Pathologic Function)\tWall of abdomen proper (Subdivision of cardinal body part)\tCimicifuga racemosa homeopathic preparation (Organic Chemical)", + "output": "Wall of abdomen proper (Subdivision of cardinal body part)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of mesoderm cell fate determination.\nConcepts: PE Immunoconjugate (Pharmacologic Substance)\tSkin of Head (Skin, Human)\tMouflon (Caprinae)\tself organization (Personality)\tupregulation of mesodermal cell fate determination (positive regulation of cell fate determination)", + "output": "upregulation of mesodermal cell fate determination (positive regulation of cell fate determination)" + }, + { + "input": "Definition: Atrophic described as disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.\nConcepts: history physicals (INTERVIEWS, HISTORIES AND PHYSICAL EXAMINATIONS)\tfibrin monomers (Biologically Active Substance)\tStage II Diffuse Small Cleaved Cell Lymphoma (Adult Diffuse Small Cleaved Cell Lymphoma)\tFuchs Endothelial Corneal Dystrophy (Hereditary Diseases)\tPigmentary Change of Skin (Finding)", + "output": "Fuchs Endothelial Corneal Dystrophy (Hereditary Diseases)" + }, + { + "input": "Definition: something described as red-colored, striated conical structures of the medullary portion of the kidney. The number of these structures varies from eight to eighteen.\nConcepts: No labial escape (Impairment of Lip Closure)\tPyramid of Malpighi (Body Part, Organ, or Organ Component)\tTroublesome Pain (Pain)\tGANGLIOGLIOMA, BENIGN (Neoplastic Process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RB1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Pyramid of Malpighi (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cyclophosphamide, vincristine, methotrexate with leucovorin rescue, and cytarabine that may be used in the treatment of non-Hodgkin lymphomas (NHL).\nConcepts: Jejunum and Ileum Neuroendocrine Tumor pNX TNM Finding v8 (Finding)\tATP:glutamine synthetase adenylyltransferase activity (Molecular Function)\tCyclophosphamide/Oncovin/Methotrexate/Leucovorin/Ara-C (Therapeutic or Preventive Procedure)\tWalking on tiptoes (Central Nervous System)\tdown-regulation of complement-dependent cytotoxicity (Cell Function)", + "output": "Cyclophosphamide/Oncovin/Methotrexate/Leucovorin/Ara-C (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as this gene is involved in serine/threonine phosphorylation.\nConcepts: PQL1612 (Intellectual Product)\tprotein kinase AMP-activated catalytic subunit alpha 1 (Gene or Genome)\thalogen metabolism (small molecule metabolic process)\tGrade 4 Tumor Hemorrhage, CTCAE (Tumor Hemorrhage, CTCAE)\tstructural constituent of adult chitin-based cuticle (Molecular Function)", + "output": "protein kinase AMP-activated catalytic subunit alpha 1 (Gene or Genome)" + }, + { + "input": "Definition: something described as region of serous pericardium surrounding the proximal part of the superior pulmonary vein.\nConcepts: PLC beta (1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase)\tpositive regulation of alpha-beta T-lymphocyte differentiation (positive regulation of alpha-beta T cell activation)\tCell, Feeder (Cell)\tSerous pericardium of superior pulmonary vein (Body Location or Region)\ttecemotide (Biologically Active Substance)", + "output": "Serous pericardium of superior pulmonary vein (Body Location or Region)" + }, + { + "input": "Definition: Acute inflammation described as an infection of the skin and subcutaneous tissues with induration and erythema.\nConcepts: inhibition of defence response to bacteria (Biologic Function)\tEmotion Recognition Test Functional Test (Functional assessment)\tLaburnum anagyroides preparation (Homeopathic remedies letter L)\tCellulitis NOS (Abnormality of connective tissue)\tPersonal Health Screening Behavior (Finding)", + "output": "Cellulitis NOS (Abnormality of connective tissue)" + }, + { + "input": "Definition: Clostridium species described as a species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is indole negative, ferments glucose but not mannose and does not reduce nitrate. C. putrificum is considered pathogenic and may cause post-operative tetanus.\nConcepts: Simple new 15 minutes in-office nutrition intake (Health Care Activity)\tIVD Test Reagent/Kits, Serology, Parasite, Trypanosoma cruzi, Antibody (Medical Device)\tCrystallization (Chemistry, Physical)\tClass agnatha - jawless fish (Fish)\tPacinia putrifica (C [Preparations])", + "output": "Pacinia putrifica (C [Preparations])" + }, + { + "input": "Definition: something described as a superficial feature of the cerebellum located between crus Ia and crus Ip ( Madigan-1971 ).\nConcepts: Hypopharyngeal Cancer pT1 TNM Finding v6 (Finding)\tintracrural fissure 1 (Posterior superior ansiform lobule of cerebellum)\tliver and intrahepatic bile duct carcinoma (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)\tMMS206A (MMSE-2 Standard Version Functional Test Question)\tAdditional Surgery (Therapeutic or Preventive Procedure)", + "output": "intracrural fissure 1 (Posterior superior ansiform lobule of cerebellum)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of receptor-mediated endocytosis involved in cholesterol transport.\nConcepts: Sperm Transport (Cell Movement)\tdown-regulation of receptor-mediated endocytosis involved in cholesterol transport (Cell Function)\tpositive regulation of cilium beat frequency involved in ciliary motility (regulation of cilium beat frequency involved in ciliary motility)\tLinear Eccrine Poroma (Benign Eccrine Neoplasm)\tCollection, Bone Marrow (Laboratory Procedure)", + "output": "down-regulation of receptor-mediated endocytosis involved in cholesterol transport (Cell Function)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the 7-dehydrocholesterol reductase (DHCR7) gene, located at chromosome 11q13.4, which encodes the protein 7-dehydrocholesterol reductase. Genetic variants at this locus have been associated with Smith-Lemli-Opitz syndrome.\nConcepts: bacterial extracellular vesicle (Extracellular Vesicles)\tEsters (carbonyl compound)\tregulation of plasma membrane repair (regulation of wound healing)\tType 1 diabetes mellitus - poor control (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DHCR7 (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DHCR7 (Medical Device)" + }, + { + "input": "Definition: Research Activity described as an activity defined at a global library level that identifies a characteristic or requirement intended to be applied to a potential study subject to determine whether they may not participate in a study.\nConcepts: Defined Inclusion Criterion (Research Activity)\tSODIUM CHOLATE (Pharmacologic Substance)\tWhole Genome Amplification (Molecular Genetic Technique)\tMedia Intervention (Behavioral, Psychological or Informational Intervention)\tinjury to brachial plexus nerve root (Peripheral Nerve Injuries)", + "output": "Defined Inclusion Criterion (Research Activity)" + }, + { + "input": "Definition: Physiologic Function described as abnormal responses to sunlight or artificial light due to extreme reactivity of light-absorbing molecules in tissues, especially skin.\nConcepts: GNA11 Mutation Analysis (Genetic Variation Analysis)\tNonfunctional Pituitary Macroadenoma (Pituitary Gland Macroadenoma)\tGrade 4 Lymph gland infection (Finding)\tnonvisual photosensitivity (Physiologic Function)\tReceptors, LPA (Receptors, Lysophospholipid)", + "output": "nonvisual photosensitivity (Physiologic Function)" + }, + { + "input": "Definition: something described as a laboratory test result indicating elevated triglyceride concentration in the blood.\nConcepts: Orthoses, Upper Limb, Wrist-Hand, Functional, Powered (Orthoses, Upper Limb, Wrist-Hand, Functional)\tLysozyme Measurement (Lysosomal enzyme analyses)\tHypertriglyceridemia (Abnormal Blood Chemistry and Hematology Test Result)\tAlgorithm (Intellectual Product)\tMathematical Science Occupations (Occupation or Discipline)", + "output": "Hypertriglyceridemia (Abnormal Blood Chemistry and Hematology Test Result)" + }, + { + "input": "Definition: something described as antibacterial against mainly gram negative organisms. It is used for urinary tract and intestinal infections.\nConcepts: Irregular end part of finger bones (Abnormal epiphysis morphology of the phalanges of the hand)\tFLAG-Ida (Chemotherapy Regimen Used to Treat Childhood Acute Myeloid Leukemia)\tPyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)- (Anti-Infective Agents, Urinary)\tlong qt syndrome (Cardiac channelopathy)\tPerformed Activity Fasting Status Indicator (Fasting Status Indicator)", + "output": "Pyrido(2,3-d)pyrimidine-6-carboxylic acid, 8-ethyl-5,8-dihydro-5-oxo-2-(1-pyrrolidinyl)- (Anti-Infective Agents, Urinary)" + }, + { + "input": "Definition: something described as a chromosome band present on 20q\nConcepts: Subglottic Cancer pT4a TNM Finding v8 (Subglottic Cancer pT4 TNM Finding v8)\tACE inhibitor fetopathy (Fetal Diseases)\t20q12-q13.12 (Cell Component)\tMelanoma of Retina (Malignant neoplasm of retina)\tpollen sperm cell differentiation (cellular process involved in reproduction in multicellular organism)", + "output": "20q12-q13.12 (Cell Component)" + }, + { + "input": "Definition: something described as gastroscopes with a nonrigid (i.e., flexible) structure, which are capable of being manipulated and pointed in different directions through the lumen of the curved path of the upper gastrointestinal tract. Flexible gastroscopes usually include a fiberoptic illumination and imaging system that facilitates the examination and performance of therapeutic procedures. The sheath is usually made of plastic.\nConcepts: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light (Molecular Function)\tPaget's+intraductal ca breast (Ductal, lobular AND/OR medullary neoplasm)\tVagina Neoplasm (Vaginal mass)\tGastroscopes, Flexible (Gastroscopes)\tMelanoma Involvement of Regional Cutaneous or Subcutaneous Tissue (Progressive Neoplastic Disease)", + "output": "Gastroscopes, Flexible (Gastroscopes)" + }, + { + "input": "Definition: negative regulation of biological process described as any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.\nConcepts: Primary non-gestational ovarian choriocarcinoma (Neoplastic Process)\tDouble layered patella (Abnormal patella morphology)\tSmall Area Analysis (Research Activity)\tdown regulation of cellular process (negative regulation of biological process)\tFactor, NFE2 Transcription (Biologically Active Substance)", + "output": "down regulation of cellular process (negative regulation of biological process)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: eriodictyol dibenzoylmethane tautomer + UDP-alpha-D-glucose <=> 8C-beta-D-glucosyl-2-hydroxyeriodictyol + UDP(3-) + H+.\nConcepts: eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity (Molecular Function)\tbundle of His cardiac muscle cell action potential (Cell Function)\tcGMP catabolism (Molecular Function)\tflukes (Eukaryote)\tEast Asian country (Asia)", + "output": "eriodictyol dibenzoylmethane tautomer 8C-glucosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Cell Function described as any process in which a protein is transported to, or maintained in, a specific location.\nConcepts: FAC06115 (Intellectual Product)\tMYBLAT3 (Precursor Plasma Cell Count)\tCystatin Family Gene (Gene or Genome)\tmagnolia glauca/sweet magnol (Homeopathic remedies letter M)\tprotein localisation (Protein Metabolism Process)", + "output": "protein localisation (Protein Metabolism Process)" + }, + { + "input": "Definition: something described as a female who shares with her sibling the genetic makeup inherited from both of the biological parents.\nConcepts: Endovascular Procedure Training Simulators (Simulators, Training)\tFoetal giant (Foetal growth complications)\tNasal Cavity and Paranasal Sinuses Cancer pM1 TNM Finding v8 (Finding)\tcysteine-type endopeptidase inhibitor activity (Molecular Function)\tSISTER, FULL (Family Group)", + "output": "SISTER, FULL (Family Group)" + }, + { + "input": "Definition: Medical Device described as an AC-powered medical examination light is an AC-powered device intended for medical purposes that is used to illuminate body surfaces and cavities during a medical examination.\nConcepts: Left Lisfranc ligament (Lisfranc ligament)\tCARBON MONOXIDE (Acid-base marker or blood gas)\tRespiratory syncytial vir grp (Virus)\tDEVICE, MEDICAL EXAMINATION, AC POWERED (Medical Device)\tBattery Problem (Power Problem)", + "output": "DEVICE, MEDICAL EXAMINATION, AC POWERED (Medical Device)" + }, + { + "input": "Definition: amdinocillin described as the pivoxil ester form of a semisynthetic, broad spectrum beta-lactam penicillin with antibacterial activity. Amdinocillin specifically binds to and inactivates penicillin-binding protein 2 (PBP 2) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall, eventually causing cell lysis.\nConcepts: Millettia / ji xue teng (Plant)\tChildhood Alveolar Soft-Part Sarcoma (cellular diagnosis, childhood soft tissue sarcoma)\tHPV E6/E7 DNA vaccine GX-188E (Pharmacologic Substance)\tProduct containing pivmecillinam (Anti-Bacterial Agents)\tTURNER SYNDROME (Disorder of body cavity)", + "output": "Product containing pivmecillinam (Anti-Bacterial Agents)" + }, + { + "input": "Definition: 11-oxycorticosteroid described as the valerate salt form of hydrocortisone, a synthetic glucocorticoid receptor agonist with antiinflammatory, antipruritic and vasoconstrictive effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2. Lack of phospholipase A2 prevents the release of arachidonic acid, precursor for inflammatory mediator prostaglandins and leukotrienes, from the cell membrane. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production.\nConcepts: Grade 1 Central Nervous System Necrosis, CTCAE (Finding)\tObese class III (Finding of body mass index)\tHydrocortisone Valerate (Pharmacologic Substance)\tSafety, Food (Poisoning, Toxicology, Environmental Health)\tSecondary Chondrosarcoma (Bone Sarcoma)", + "output": "Hydrocortisone Valerate (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body.\nConcepts: Neurofilament Triplet M Protein (Biologically Active Substance)\tright posteriolateral cilium (Cell Component)\tDeep Sedation (Anesthesia and Analgesia)\tSPANXN5 wt Allele (SPANXN5 gene)\t16S rRNA (guanine(1207)-N(2))-methyltransferase activity (Genetic Function)", + "output": "right posteriolateral cilium (Cell Component)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic neurological disorder characterized by infant hypotonia and feeding difficulties, global development delay, mild to moderate intellectual disability, delayed independent ambulation, broad-based gait with arms upheld and flexed at the elbow with brisk walking or running, and limited language skills. Behavior patterns are highly variable and range from sociable and affectionate to autistic behavior. Caused by homozygous mutation in the HERC2 gene on chromosome 15q13.\nConcepts: Chloranil (Hazardous or Poisonous Substance)\tValvular regurgitation, NOS (Cardiovascular finding)\tDevelopmental delay with autism spectrum disorder and gait instability (Disease or Syndrome)\tEIEE17 (Gene or Genome)\tNemaline Myopathy Gene Deletion/Duplication Panel Reagents (IVD Panels, Human Genetics, Neuromuscular Disorder, Nemaline Myopathy)", + "output": "Developmental delay with autism spectrum disorder and gait instability (Disease or Syndrome)" + }, + { + "input": "Definition: something described as catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane.\nConcepts: 2-hydroxypropyl-CoM lyase activity (Molecular Function)\tPleuroscope (Body cavity endoscope)\tLiver Cancer pM1 TNM Finding v6 (Finding)\tCY (Europe, Eastern)\tMore language (Language)", + "output": "2-hydroxypropyl-CoM lyase activity (Molecular Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a transferrin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the transferrin (an iron-binding and transporting serum protein) in serum, plasma, and other body fluids. Measurement of transferrin levels aids in the diagnosis of malnutrition, acute inflammation, infection, and red blood cell disorders, such as iron deficiency anemia.\nConcepts: 2,5 Diaminopentanoic Acid (Nonessential amino acid)\tTRANSFERRIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tBradykinin Receptor B1 Measurement (Laboratory Procedure)\teflornithine hydrochloride ointment (Clinical Drug)\tRectum/Anus (Anus)", + "output": "TRANSFERRIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a prolonged-release tablet formulation containing the quinazoline anagrelide, with antiplatelet activity. Although the exact mechanism of action through which anagrelide exerts its effect has yet to be fully elucidated, this agent inhibits the maturation of megakaryocytes into platelets, which reduces platelet production. Anagrelide also inhibits cyclic AMP phosphodiesterase III (PDEIII), which prevents PDEIII-mediated platelet aggregation. This may prevent essential thrombocythemia and thrombosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C114497\" active clinical trials using this agent.\nConcepts: anagrelide retard (Antiplatelet Agents)\tAtrophy, Multiple System (Movement Disorders)\tCardiorespiratory Fitness (Health Status)\tIVD Test Reagent/Kits, Serology, Virus, Enterovirus, Antigen (Medical Device)\tI feel like doing all sorts of nice things (Clinical or Research Assessment Question)", + "output": "anagrelide retard (Antiplatelet Agents)" + }, + { + "input": "Definition: Pharmacologic Substance described as a pegylated derivative of the cyclic tridecapeptide compstatin and inhibitor of complement component C3 (C3) activation, with potential use as a treatment for various diseases in which excessive complement activation plays a key role, including paroxysmal nocturnal hemoglobinuria (PNH) and age-related macular degeneration (AMD). Upon administration, C3-targeted complement inhibitor APL-2 selectively binds to C3 and blocks the cleavage of C3 into C3a and C3b by C3 convertase. This prevents complement pathway activation, and inhibits complement-mediated inflammation and cell lysis. Pegylation increases compstatin's half-life, and increases its efficacy. Excessive complement activation plays a key role in various inflammatory and autoimmune diseases, and leads to tissue destruction. C3 is a crucial and central component of the complement system. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121135\" active clinical trials using this agent.\nConcepts: Proliferative Diabetic Retinopathy (Lesion of eye structure)\tMicrogram per Milligram (Unit of Mass Fraction)\tPediatric specialty (Medical Specialities)\tC3-targeted Complement Inhibitor APL-2 (Pharmacologic Substance)\tColitis (Finding)", + "output": "C3-targeted Complement Inhibitor APL-2 (Pharmacologic Substance)" + }, + { + "input": "Definition: Stick Dosage Form described as solid sterile single-dose preparation, usually rod-shaped or conical, consisting of active substance(s) dissolved or dispersed in a suitable basis that may dissolve or melt at body temperature, intended to be inserted into wounds.\nConcepts: WOUND STICK (Drug stick)\tHow much of the time did your caregiving responsibilities make it difficult for you to feel you've done what you are capable of doing (Clinical or Research Assessment Question)\tHydroxides (Inorganic Chemical)\tSDH3 Gene Mutation (Gene Mutant)\taccessory nerve nucleus (somatic motoneuron pools)", + "output": "WOUND STICK (Drug stick)" + }, + { + "input": "Definition: something described as an abnormality of the cortex of the kidney.\nConcepts: Abnormality of renal cortex morphology (Anatomical Abnormality)\tKallikrein Trypsin Inactivator (Plasmin inhibitor agent)\tdisorders of manganese metabolism hypermanganesemia with dystonia (Hereditary disorder of nervous system)\tFluid Shifts (Physiological Phenomena)\tCDISC SDTM Cardiac Valvular Stenosis Severity Terminology (Unused Subset Concept)", + "output": "Abnormality of renal cortex morphology (Anatomical Abnormality)" + }, + { + "input": "Definition: Vitamin measurement described as a measurement of the alpha tocopherol in a biological specimen.\nConcepts: Alpha Tocopherol Measurement (Vitamin E Assay)\tPlagiarism (Publishing)\tReceptors, KIR2DL3 (Amino Acid, Peptide, or Protein)\tGrade 2 Neonatal Rash, Adverse Event (Neonatal Rash, Adverse Event)\tmania (Mood alterations with manic symptoms)", + "output": "Alpha Tocopherol Measurement (Vitamin E Assay)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale - Dressing & Grooming: Are you able to dress yourself, including tying shoelaces and doing buttons?\nConcepts: myokymia; facial (Head finding)\tDDS02-My Nagging Hurting Relationship (PARENT-DDS Questionnaire Question)\tShortening Fraction (Diagnostic Procedure)\tEWS-CREB1 Fusion Gene (Gene or Genome)\tHAQ0201 (Intellectual Product)", + "output": "HAQ0201 (Intellectual Product)" + }, + { + "input": "Definition: Community Risk Management described as providing community's members with education and/or information regarding large scale disasters to prepare their community to respond effectively to a large scale disaster.\nConcepts: Toxin B-Producing Clostridium difficile (Laboratory Procedure)\tdisaster prep educ.cmunt (Therapeutic or Preventive Procedure)\tSpongiotic dermatitis (Dermatitis)\tprotein localization to cell periphery (Cell Function)\tchondroitin sulfate proteoglycan formation, polysaccharide chain formation (cellular polysaccharide biosynthetic process)", + "output": "disaster prep educ.cmunt (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Cell Function described as a cellular process that results in the controlled breakdown of synapse. After it starts the process is continuous until the synapse has disappeared.\nConcepts: Swiss Webster mouse (Mammal)\tQTcF Prolongation (Finding)\tsynapse clearance (Cell Function)\tCellular hypersensitivity to diepoxybutane (Abnormality of DNA repair)\tLY2228820 dimesylate (Organic Chemical)", + "output": "synapse clearance (Cell Function)" + }, + { + "input": "Definition: Study Reports: Toxicology described as a study that assesses the toxic effects of a compound in animals after a single administration.\nConcepts: magnesium chelatase complex (catalytic complex location)\tPEDSQL NEUROMUSCULAR MODULE V3 TEEN (Clinical or Research Assessment Questionnaire)\t17: 71509014-71513251 (Chromosome 17 Physical Location)\tDAGRPID (Intellectual Product)\tToxicology: Single Dose Toxicity [Species And Route] (Study Reports: Toxicology)", + "output": "Toxicology: Single Dose Toxicity [Species And Route] (Study Reports: Toxicology)" + }, + { + "input": "Definition: Amyloidosis, Familial described as a rare neurodegenerative disease with characteristics of progressive cataracts, hearing loss, cerebellar ataxia, paranoid psychosis and dementia. Neuropathological features are diffuse atrophy of all parts of the brain, chronic diffuse encephalopathy and the presence of extremely thin and almost completely demyelinated cranial nerves. Caused by mutation in the ITM2B gene.\nConcepts: podocyte differentiation (Cell Function)\tBASOPHILIC GRANULES (Cell Component)\tBothered by Look of Hands or Nails (Intellectual Product)\tprotein N-linked glycosylation (Molecular Function)\tADan amyloidosis (Hereditary disorder of nervous system)", + "output": "ADan amyloidosis (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Foot Deformities described as spontaneous detachment of a foot from the body.\nConcepts: methyl accepting chemotaxis protein complex (Cell Component)\tAutoamputation of foot (Autoamputation)\tCDISC SDTM Cardiac Valvular Stenosis Severity Terminology (Intellectual Product)\tCAR 19-28z T Cells (Cell)\tPulmonary Fibrosis (Finding)", + "output": "Autoamputation of foot (Autoamputation)" + }, + { + "input": "Definition: Quantitative Concept described as statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.\nConcepts: Linear Models (Models, Statistical)\tpericardium; effusion (effusion)\tFavorable Shimada Classification (Shimada Classification System)\tDominance-Subordination (Social Behavior)\tresponse to salinity (Osmoregulation)", + "output": "Linear Models (Models, Statistical)" + }, + { + "input": "Definition: something described as any one of several evaluation/assessment tools used to ascertain a patient's complaints with regard to his or her specific condition or diagnosis.\nConcepts: CATHETER, ASSISTED REPRODUCTION (Medical Device)\tENTEROCOCCUS THAILANDICUS (Enterococcus)\talpha4-beta1 integrin-CD81 complex (Cell Component)\tSymptom-Specific Assessment Tool (Research or Clinical Assessment Tool)\tTh1 cell activation (Cell Function)", + "output": "Symptom-Specific Assessment Tool (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Aplasia/hypoplasia involving bones of the hand described as absence or underdevelopment of the carpal bones.\nConcepts: HLA-B*46:01 Positive Cells Present (Laboratory or Test Result)\tElevated bronchoalveolar lavage fluid eosinophil proportion (Abnormal cellular composition of bronchoalveolar fluid)\tJakafi Regimen (Therapeutic or Preventive Procedure)\tObesity in Children (Obesity)\tAbsent/small wrist bones (Aplasia/hypoplasia involving bones of the hand)", + "output": "Absent/small wrist bones (Aplasia/hypoplasia involving bones of the hand)" + }, + { + "input": "Definition: something described as the guidelines and policy statements set forth by the editor(s) or editorial board of a publication.\nConcepts: Editorial Policy (Publishing)\t25S rRNA (adenine(645)-N(1))-methyltransferase (rRNA (adenine) methyltransferase activity)\tThin clavicle (Form of clavicle - finding)\tBISMARCK BROWN Y (Indicator, Reagent, or Diagnostic Aid)\tncRNA processing (ncRNA metabolic process)", + "output": "Editorial Policy (Publishing)" + }, + { + "input": "Definition: Intellectual Product described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Sudden accidental death: Doesn't apply.\nConcepts: LIGHT, ULTRAVIOLET, DERMATOLOGICAL (Medical Devices)\tVerbena, Flower essence (Flower Essences)\tDicloxacillina (semisynthetic penicillins)\tAllnortoxiferine (Organic Chemical)\tLEC01-Sudden Accidental Death: Not Apply (LEC-5 Standard Version Questionnaire Question)", + "output": "LEC01-Sudden Accidental Death: Not Apply (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: aminotransferase activity described as catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine.\nConcepts: gamma-aminobutyrate transaminase (glyoxylate dependent) activity (aminotransferase activity)\tpT4 Cancer of the Liver TNM Finding v6 (Finding)\tGranules for suspension for injection (Granule for Suspension Dosage Form)\tSoftware, Device Testing, Ventilator (Software, Device Testing)\tLocoweeds (Fabaceae)", + "output": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity (aminotransferase activity)" + }, + { + "input": "Definition: Cell Component described as the component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.\nConcepts: BCAS2 wt Allele (BCAS2 gene)\tCreutzfeldt-Jakob variant disease (Dementia)\tdental development (Growth and Development function)\tCD 116 ANTIGENS (Immunologic Factor)\tintegral to contractile vacuolar membrane (Cell Component)", + "output": "integral to contractile vacuolar membrane (Cell Component)" + }, + { + "input": "Definition: Nitrogen mustard analogues described as a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities. In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death.\nConcepts: Exercise-induced anaphylaxis (Anaphylactoid Reaction)\tCyclophosphamide (Pharmacologic Substance)\tEphrin Receptor EphA4 (Receptor Protein-Tyrosine Kinases)\tWD5-How Many Days Reduce Activities (Intellectual Product)\tBenign Mixed Tumor of the Lacrimal Gland (Benign neoplasm of lacrimal gland)", + "output": "Cyclophosphamide (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as an increase in the quantity of space occupied by the thalamus.\nConcepts: Enlarged thalamic volume (Finding)\tGlands of Zeis (Skin of breast proper)\tDown Syndrome (Syndrome)\tSPECTROPHOTOMETRIC METHOD, PREGNANEDIOL (Medical Device)\tspectinomycin hydrochloride (Organic Chemical)", + "output": "Enlarged thalamic volume (Finding)" + }, + { + "input": "Definition: Medical Device described as an introduction/drainage catheter is a device that is a flexible single or multilumen tube intended to be used to introduce nondrug fluids into body cavities other than blood vessels, drain fluids from body cavities, or evaluate certain physiologic conditions. Examples include irrigation and drainage catheters, pediatric catheters, peritoneal catheters (including dialysis), and other general surgical catheters. An introduction/drainage catheter accessory is intended to aid in the manipulation of or insertion of the device into the body. Examples of accessories include adaptors, connectors, and catheter needles.\nConcepts: Autosomal recessive optic atrophy OPA7 (Disease or Syndrome)\toxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor (Molecular Function)\tBA46 (Brodmann area)\tInadequate molybdenum intake (Finding)\tCATHETER, CONTINUOUS IRRIGATION (Medical Device)", + "output": "CATHETER, CONTINUOUS IRRIGATION (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Physical Well-Being: I have nausea.\nConcepts: Pharmacogenetics Panel Test Reagents (IVD Panels, Human Genetics)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child - Take Long Time to Eat (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)\tFACT-HEP Version 4 - I Have Nausea (FACT-HEP Version 4 Questionnaire Question)\tpositive regulation of site selection involved in cell cycle cytokinesis (positive regulation of cytokinesis)\tIVD Test Reagent/Kits, Hematology, Coagulation, Thrombophilia Marker, Platelet Factor 4 (IVD Test Reagent/Kits, Hematology, Coagulation, Thrombophilia Marker)", + "output": "FACT-HEP Version 4 - I Have Nausea (FACT-HEP Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as michigan Neuropathy Screening Instrument - History: Does it hurt when the bed covers touch your skin?\nConcepts: Tillandsia L., 1753 (Bromeliaceae)\tDALK - deep anterior lamellar keratoplasty (Deep lamellar keratoplasty)\testablishment of protein localization to mitochondrion (establishment of protein localization to organelle)\tMNSI106 (Intellectual Product)\tColorectal Kaposi Sarcoma (Colorectal Sarcoma)", + "output": "MNSI106 (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.\nConcepts: Polypyrimidine Tract-Binding Protein 3 (Amino Acid, Peptide, or Protein)\tneurexin family protein binding (signaling receptor binding)\thuman papillomavirus 16 E7 peptide (Immunologic Factor)\tCervical Carcinoma pN0 TNM Finding v8 (Cervical Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tGrade 4 Ovarian rupture (Finding)", + "output": "neurexin family protein binding (signaling receptor binding)" + }, + { + "input": "Definition: Clinical Enzyme Tests described as a measurement of the lipoprotein associated phospholipase A2 in a biological specimen.\nConcepts: Ovarian Dermoid Cyst with Angiosarcoma (Ovarian Dermoid Cyst with Secondary Sarcoma)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue, Jo-1 Antibody (Medical Device)\tmain body follicle cell migration (ovarian follicle cell migration)\tMyeloma (Intellectual Product)\tLipoprotein Associated Phospholipase A2 (Protein or Enzyme Type Measurement)", + "output": "Lipoprotein Associated Phospholipase A2 (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: something described as level 3 Non-reassuring Fetal Status is defined by the presence of the following criteria: A fetal heart pattern that is detected via intermittent auscultation, and that is suggestive of fetal hypoxia, including the following requirements that must be met: a) Baseline fetal heart rate less than 110 bpm or greater than 160 bpm; b) Presence of repetitive or prolonged (greater than 3 minutes) decelerations; c) More than five contractions in a ten minute period.\nConcepts: PR0104 (Intellectual Product)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 3 Non-reassuring Fetal Status (Intellectual Product)\tHSP40 Protein Family (Heat shock proteins)\tBacillus a (Lactobacillus)\tnegative regulation of immune response to tumour cell (negative regulation of response to tumor cell)", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 3 Non-reassuring Fetal Status (Intellectual Product)" + }, + { + "input": "Definition: something described as a question about an individual's ability to bicycle 2 miles nonstop.\nConcepts: Bicycling 2 Miles Nonstop (Intellectual Product)\tliver ducts (Bile duct part)\tVIBECOTAMAB (Antineoplastic Antibody)\tprobiotic (Bacterium)\tDRM complex (RNA polymerase II transcription repressor complex)", + "output": "Bicycling 2 Miles Nonstop (Intellectual Product)" + }, + { + "input": "Definition: something described as a Family Medicine Physician who practices Sleep Medicine is certified in the subspecialty of sleep medicine and specializes in the clinical assessment, physiologic testing, diagnosis, management and prevention of sleep and circadian rhythm disorders. Sleep specialists treat patients of any age and use multidisciplinary approaches. Disorders managed by sleep specialists include, but are not limited to, sleep related breathing disorders, insomnia, hypersomnias, circadian rhythm sleep disorders, parasomnias and sleep related movement disorders.\nConcepts: Posts, Dental Root (Dental Equipment and Supplies)\tAllopathic & Osteopathic Physicians; Family Medicine, Sleep Medicine (Professional or Occupational Group)\tAggressive Adult Non-Hodgkin's Lymphoma (Adult Non-Hodgkin Lymphoma)\taconitum lycotonum/great yel (Homeopathic remedies letter A)\tProlymphocytes (Lymphocyte Count measurement)", + "output": "Allopathic & Osteopathic Physicians; Family Medicine, Sleep Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Red Blood Cell Count measurement described as the determination of the number of reticulocytes in a blood sample.\nConcepts: Sphingosine-1-Phosphate Phosphatase 2 wt Allele (SGPP2 gene)\tTrigonocephaly, short stature, and retarded psychomotor development (congenital malformation syndromes affecting multiple systems)\tcircadian sleep/wake cycle, sleep (circadian sleep/wake cycle process)\tregulation of mesenchymal cell apoptosis (Cell Function)\treticulocyte count (MISCELLANEOUS HEMATOLOGIC TESTS)", + "output": "reticulocyte count (MISCELLANEOUS HEMATOLOGIC TESTS)" + }, + { + "input": "Definition: Exocytosis described as a process by which cells release or lose their intracytoplasmic granules.\nConcepts: Degranulation (Exocytosis)\t1p34.3 (Cell Component)\tSurgically-Created Structures (Equipment and Supplies)\tAndrogen and Estrogen Metabolism (Functional Concept)\tPARIETAL LOBE (Brain, Cerebral Hemisphere, Corpus Callosum and Rhinencephalon)", + "output": "Degranulation (Exocytosis)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of vismodegib that may be used in the treatment of basal cell skin cancer and adult medulloblastoma.\nConcepts: Clamps, External Occlusion (Clamp)\tONO4578 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tErivedge Regimen (Regimen Used to Treat Central Nervous System Neoplasm)\tAutosomal Dominant Severe Congenital Neutropenia (Autosomal dominant hereditary disorder)\tInvestigator Site (Clinical Study Site)", + "output": "Erivedge Regimen (Regimen Used to Treat Central Nervous System Neoplasm)" + }, + { + "input": "Definition: something described as this gene is involved in cell cycle checkpoint regulation.\nConcepts: RGNT (Neoplasms, Neuroepithelial)\tMPS1, YEAST, HOMOLOG OF (Gene or Genome)\trhombomere 7 formation (Organism Function)\tmitotic spindle microtubule (Cell Component)\tHIV ANTIBODY TEST (Serology: virus identified procedure)", + "output": "MPS1, YEAST, HOMOLOG OF (Gene or Genome)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine has been studied as a rescue agent to reduce the toxicities associated with 5-fluorouracil (5-FU), thereby allowing the administration of higher doses of 5-FU in chemotherapy regimens.\nConcepts: ERT - Total Negative Stimuli Expected (ERT Functional Test Question)\tSpindle Cell Melanoma of the Ciliary Body (Malignant melanoma of ciliary body)\tinfected host cell surface knob (host cell cytoplasm part)\tProduct containing uridine (Pyrimidine Nucleosides)\tleukocyte proliferation (cell population proliferation)", + "output": "Product containing uridine (Pyrimidine Nucleosides)" + }, + { + "input": "Definition: something described as a measurement of the keratocytes in a biological specimen.\nConcepts: Anaplasias (Maturation defect)\tpigment metabolic process involved in developmental pigmentation (pigment metabolic process involved in pigmentation)\tKERAT (Cell Count)\tphenol-beta-D-glucosyltransferase activity (Molecular Function)\tMitral valve.annulus (Heart part)", + "output": "KERAT (Cell Count)" + }, + { + "input": "Definition: fludarabine described as the phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1102\" active clinical trials using this agent.\nConcepts: Jejunum and Ileum Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Jejunum and Ileum Neuroendocrine Tumor Pathologic TNM Finding v8)\tIncrease in tryptophan content of the diet compared to the assessed baseline intake of tryptophan for the individual. (Therapeutic or Preventive Procedure)\tfludarabine monophosphate (Antimetabolites)\tClonal (Biospecimen)\tnegative regulation of convergent extension involved in somitogenesis (regulation of convergent extension involved in somitogenesis)", + "output": "fludarabine monophosphate (Antimetabolites)" + }, + { + "input": "Definition: Molecular Function described as the action of a molecule that contributes to the structural integrity of a postsynaptic specialization.\nConcepts: CM (Intellectual Product)\tAequorins (Luminescent Proteins)\tstructural constituent of postsynaptic specialization (structural constituent of postsynapse)\tSKIN ABRASION (Procedure on skin)\tVeteran (Special Population)", + "output": "structural constituent of postsynaptic specialization (structural constituent of postsynapse)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual's problems with cognitive function interferes or interfered with their ability to work.\nConcepts: Cognitive Problems Have Interfered with Ability to Work (Intellectual Product)\themolytic beta strep (Bacterium)\tMilk Secretions (Reproductive Physiological Processes)\tSMDDS112 (SMDDS Version 1.0 Questionnaire Question)\tStage IIB Choroidal and Ciliary Body Melanoma AJCC v8 (Neoplastic Process)", + "output": "Cognitive Problems Have Interfered with Ability to Work (Intellectual Product)" + }, + { + "input": "Definition: something described as delivery of a dead fetus greater than 22 weeks but less than 28 weeks gestational age, and/or whose birth weight is greater than 500 grams but less than 1,000 grams.\nConcepts: ImagingAcquisitionProtocolElement.imageTypeCode (Intellectual Product)\tAutosomal dominant late-onset retinal degeneration (Autosomal dominant hereditary disorder)\tSkin Melanoma Pathologic Primary Tumor TNM Finding v7 (Finding)\tEarly Stillbirth (Stillbirth)\tProjector Screens (Manufactured Object)", + "output": "Early Stillbirth (Stillbirth)" + }, + { + "input": "Definition: something described as transcription factor MafB (323 aa, ~36 kDa) is encoded by the human MAFB gene. This protein plays a role in both the modulation of transcription and the negative regulation of erythrocyte differentiation.\nConcepts: IPA01-Total Sitting Minutes on Wednesday (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tOropharyngeal (p16-Negative) Cancer pTis TNM Finding v8 (Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8)\tMAFB protein, human (Amino Acid, Peptide, or Protein)\tTUBERCULOSIS MILIARY (Korean Standard Classification of Disease Version 5)\tPlacental Villus (Placenta part)", + "output": "MAFB protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a monoclonal antibody directed against a specific tumor-associated antigen (TAA).\nConcepts: deliveryMechanismCode (Intellectual Product)\tBcl-2-Binding Protein (Biologically Active Substance)\tShared Anti-Idiotype-AB-S021A (Monoclonal Antibodies)\tLEC-5 Standard Version - Natural Disaster: Not Apply (LEC-5 Standard Version Questionnaire Question)\t2: 74971437-75032136 (Chromosome 2 Physical Location)", + "output": "Shared Anti-Idiotype-AB-S021A (Monoclonal Antibodies)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in the negative regulation of cell growth.\nConcepts: N33 (Gene or Genome)\tMASCT-I (Immunologic Factor)\tCellvibrio (ex Winogradsky 1929) Blackall et al. 1986 emend. Suarez et al. 2014 (Bacterium)\tNorepinephrine (Adrenal medulla tests)\tOrthoses, Lower Limb, Total, Gait, Self-Propelled (Medical Device)", + "output": "N33 (Gene or Genome)" + }, + { + "input": "Definition: Functional Concept described as the Common sub-domain represents the semantics that are common to all (or most) of the other sub-domains, for example, it includes semantics for such things as people, organizations, places and materials.\nConcepts: Learnings, Serial (Verbal Learning)\tGastric Cancer pN2 TNM Finding v6 (Gastric Cancer Pathologic Regional Lymph Nodes TNM Finding v6)\tPancreatic Tubular Adenocarcinoma (Pancreatic neoplasms malignant)\tSolitary plasmacytoma NOS (Plasma cell myeloma/plasmacytoma)\tCommon Sub-Domain (Functional Concept)", + "output": "Common Sub-Domain (Functional Concept)" + }, + { + "input": "Definition: System disorder of the nervous system described as abnormal involuntary motor processes that occur due to underlying disease processes.\nConcepts: Aurora B Serine/Threonine Kinase Inhibitor TAK-901 (Antineoplastic Enzyme Inhibitor)\tDYSKINETIC SYNDROME (Central Nervous System)\tB-cell small lymphocytic lymphoma stage III (B-cell lymphoma stage III)\tintraperitoneal infusion (Drug Administration Routes)\tG/U mismatch-specific uracil-DNA glycosylase activity (pyrimidine-specific mismatch base pair DNA N-glycosylase activity)", + "output": "DYSKINETIC SYNDROME (Central Nervous System)" + }, + { + "input": "Definition: something described as the hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species.\nConcepts: renal amino acid absorption (Physiologic Function)\tVidaza Regimen (Therapeutic or Preventive Procedure)\tdown regulation of chemotaxis (Cell Function)\tSemen Analysis Systems (Analyzers, Laboratory)\tplasma membrane proton-transporting ATP synthase, catalytic core (plasma membrane protein complex)", + "output": "plasma membrane proton-transporting ATP synthase, catalytic core (plasma membrane protein complex)" + }, + { + "input": "Definition: Axon described as the axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to climb along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber.\nConcepts: Molecular Genetic (Science of genetics)\tMycoplasma capricolum Tully et al. 1974 (Mycoplasma species)\tclimbing fiber (Axon)\tWhite leg (Disorder of vein)\tbranch elongation involved in ureteric bud branching (Organism Function)", + "output": "climbing fiber (Axon)" + }, + { + "input": "Definition: Cullin Family Gene described as this gene plays a role in protein degradation and cell cycle arrest.\nConcepts: Esophageal Cancer (Neoplastic Process)\tlinguistic (Languages)\tcullin 3 (Gene or Genome)\tMeasurement of apolipoprotein A-II (Lipoprotein and lipid tests NEC)\t12B and MGIT (Bacterial Culture System)", + "output": "cullin 3 (Gene or Genome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as complement factor H (1231 aa, ~139 kDa) is encoded by the human CFH gene. This protein is involved in the activation of the complement pathway.\nConcepts: Epic (Intellectual Product)\tchloroplast division (chloroplast organization)\tup-regulation of skeletal muscle hypertrophy (regulation of skeletal muscle hypertrophy)\t2-linoleyl carbonate-paclitaxel (Taxane-Pocket Binding Agent)\tHuman Factor H (Complement System Proteins)", + "output": "Human Factor H (Complement System Proteins)" + }, + { + "input": "Definition: Energy Metabolism described as any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation.\nConcepts: Mimulus aurantiacus / bush musk (Pharmacologic Substance)\tPQL04-Hard to Swallow Food (PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen Questionnaire Question)\tbasal dendrite arborization (Dendritic Arborization)\tabscisic acid homeostasis (Physiologic Function)\tPhotosynthetic Phosphorylations (Photochemical Processes)", + "output": "Photosynthetic Phosphorylations (Photochemical Processes)" + }, + { + "input": "Definition: Disease or Syndrome described as mental retardation and isolated growth hormone deficiency associated with facial anomalies, gynecomastia, small testes, gothic palate, dental crowding, clinodactyly, and mild scoliosis.\nConcepts: uropathy; obstructive (Other disorders of urethra and urinary tract)\tMelanoma of Unknown Primary (Metastatic melanoma)\tX-linked mental retardation-growth hormone deficiency syndrome (Disease or Syndrome)\tsiderophore uptake transmembrane transporter activity (siderophore transmembrane transporter activity)\tHemiareflexia (Finding)", + "output": "X-linked mental retardation-growth hormone deficiency syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Analysis described as analysis of protein components in a sample. The most basic analysis involves determination of the mass or concentration of protein by any of a number of quantitative assays. Increased level of detail in the analysis requires resolution of a mixture into its component proteins. The characterization of a pure protein includes the determination of a number of its properties, among these, the molecular weight, isoelectric point, subunit composition, tryptic map, amino acid composition, amino acid sequence, hydrodynamics (s value, frictional coefficient, shape, aggregation state), thermodynamics (melting, folding, protein-protein interactions), and atomic structure (NMR, diffraction).\nConcepts: SMDDS Version 1.0 - Total Score (Finding)\tSingle S1 (Finding)\tProtein Analysis (Molecular Genetic Technique)\tfructoselysine metabolic process (amino acid metabolism)\tAdvanced Pancreatic Carcinoma (Advanced Digestive System Carcinoma)", + "output": "Protein Analysis (Molecular Genetic Technique)" + }, + { + "input": "Definition: something described as responsible for a broad range of Office of the Director strategic and financial management activities.\nConcepts: MMS104AD (Intellectual Product)\tPaired Box Transcription Factor 7 (Amino Acid, Peptide, or Protein)\tregulation of behaviour (Regulation of biological process)\tBFMO (Office of the Director)\tventral lateral nucleus (Body Part, Organ, or Organ Component)", + "output": "BFMO (Office of the Director)" + }, + { + "input": "Definition: Congenital vascular disorder described as a rare heart defect that occurs when the HEART VENTRICLES and attached valves, the MITRAL VALVE and the TRICUSPID VALVE are reversed so that the AORTA and the PULMONARY ARTERY are connected to the wrong ventricle. Although the heart valves and the two great arteries, the PULMONARY ARTERY and the AORTA are transposed, the blood flows to the correct place because the ventricles are also reversed and therefore corrects the transposition. It often occurs with other structural heart abnormalities.\nConcepts: Discordt vent/arterial connect + discord atrioventric connct (Soft tissue lesion)\tSteady (Feelings)\tPosterior Pharyngeal Wall Throat Cancer (Pharyngeal Carcinoma)\tQLES1-Interested in Problems of People (Q-LES-Q Questionnaire Question)\tInteraction, Epistatic Gene-Gene (Gene Expression Regulation)", + "output": "Discordt vent/arterial connect + discord atrioventric connct (Soft tissue lesion)" + }, + { + "input": "Definition: GAIA Insufficient Cervix Levels of Diagnostic Certainty described as level 2 Assessment of Insufficient Cervix is defined by two criteria: first, the following three requirements must be met: a) Presentation between 16 and 23 6/7 weeks gestation; b) Advanced cervical dilation greater than two centimeters, resulting in either treatment with a cerclage (cervical stitch) or preterm delivery; c) less than or equal to four contractions per hour as documented by a tocodynometer, meaning the patient is not in preterm labor; second, dilation of the internal cervical os greater than two centimeters as determined by digital examination.\nConcepts: galactose 3-O-sulfotransferase activity (sulfotransferase activity)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2 Assessment of Insufficient Cervix (Intellectual Product)\tPaediatric haematology oncology specialty (Pediatric hematology)\tEQ5D0206 (Intellectual Product)\tTemporal Regions (Body Part, Organ, or Organ Component)", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 2 Assessment of Insufficient Cervix (Intellectual Product)" + }, + { + "input": "Definition: something described as an elevation in the proportion above normal of immature B cells (CD19+/ CD21low) in circulation relative to total number of B cells. Immature B cells (IgM+) are still in final stages of development within the bone marrow. Naive B cells are those which have left the bone marrow, before they bind to the antigen for which they're specific (IgM+/IgD+).\nConcepts: methylpurine (Organic Chemical)\tsecond-DNA capture (mitotic cohesin loading)\tProduct containing imipramine (Organic Chemical)\tIncreased proportion of immature B cells (Finding)\tCHAIR, POSTURE, FOR CARDIAC AND PULMONARY TREATMENT (Medical Device)", + "output": "Increased proportion of immature B cells (Finding)" + }, + { + "input": "Definition: Intellectual Product described as the NCI term type designation for the adjectival form of a noun.\nConcepts: AD Term Type (Term Type)\tProto-Oncogene Protein, kit (Proto-Oncogene Protein c-kit)\tGaertner bacillus / bowel nosode (Organic Chemical)\tEndobrachyooesophagus (Benign Neoplasm)\tyolk granule (Cell Component)", + "output": "AD Term Type (Term Type)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 9p\nConcepts: 9p13-p12 (Cell Component)\tspongiotic dermatitis (Inflammation of specific body systems)\tSexual preference, NOS (Finding relating to sexuality and sexual activity)\tCDC group IVa (Bordetella species)\tWound Therapy Systems, Negative-Pressure (Medical Device)", + "output": "9p13-p12 (Cell Component)" + }, + { + "input": "Definition: something described as a decreased functionality of the gonad.\nConcepts: Fredrickson Type III lipidaemia (Hyperlipidemia)\tGonadotropin Deficiency (Male internal genital organ)\tDeficiencies, Riboflavin (Water soluble vitamin deficiencies)\tdown regulation of bipolar cell growth (regulation of bipolar cell growth)\tnegative regulation of granzyme B production (negative regulation of production of molecular mediator of immune response)", + "output": "Gonadotropin Deficiency (Male internal genital organ)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week, how often have you: kept your room/apartment/house cleaned to your satisfaction?\nConcepts: Left marginal arterial zone (Body Location or Region)\tQ-LES-Q - Kept Room Clean to Satisfaction (Intellectual Product)\tOperative procedure canceled before time of induction of anesthesia (Finding)\tFRIEND (CHAPTER 3 SUPPORT AND RELATIONSHIPS)\tsegment polarity determination (periodic partitioning)", + "output": "Q-LES-Q - Kept Room Clean to Satisfaction (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as the non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.\nConcepts: ADAPTATIONS PHYSIOL (Physiological Processes)\tamisometradine (Organic Chemical)\tAngioimmunoblastic Lymphadenopathy Type T-Cell Lymphoma (Immunoproliferative Disorders)\tMICRO RNA 335 (Gene or Genome)\tNON-HOUSEHOLD ENVIRONMENT (Geographic Area)", + "output": "ADAPTATIONS PHYSIOL (Physiological Processes)" + }, + { + "input": "Definition: Racial group described as denotes a person having origins in one of the indigenous people of the Caribbean.\nConcepts: CARIBBEAN INDIAN (Racial group)\tKiller Cell Immunoglobulin Like Receptor 2DL3 (Receptor)\tRRAD (Amino Acid, Peptide, or Protein)\tGsalpha Gene Mutation (Cell or Molecular Dysfunction)\tNITROFURANTOIN (Anti-Infective Agents, Urinary)", + "output": "CARIBBEAN INDIAN (Racial group)" + }, + { + "input": "Definition: something described as a subjective score of 3 on a severity scale that ranges from 0: Not at all severe to 10: most severe.\nConcepts: Severity Score 3 (Clinical or Research Assessment Answer)\tRecurrent Childhood Diffuse Astrocytoma (Recurrent Diffuse Astrocytoma)\tAntiperspirant Cream F511 (Agent Affecting Integumentary System)\tPapillomavirus Protein E4 (Biologically Active Substance)\tv-JUN Sarcoma Virus 17 Oncogene Homolog (Avian) wt Allele (Gene or Genome)", + "output": "Severity Score 3 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as change in or modification of the gastrointestinal system\nConcepts: loneliness (displeasure)\tOther Things That Have Bothered Lately (Intellectual Product)\tCervical Cancer pT0 TNM Finding v7 (Finding)\tBowel elimination alteration (Bowel elimination status)\tIPA0221C (Intellectual Product)", + "output": "Bowel elimination alteration (Bowel elimination status)" + }, + { + "input": "Definition: something described as a 4-tiered score that stratifies patients with common primary tumors metastasizing to the brain (malignant melanoma, lung, breast, kidney and gastrointestinal cancers) into subgroups with different prognoses. The score is based on age, Karnofsky performance status, number of extracranial metastases, number of brain metastases, and site of primary tumor.\nConcepts: M. quadriceps femoris (Muscle of anterior compartment of thigh)\tCD40 Agonistic Monoclonal Antibody APX005M (Pharmacologic Substance)\tUpington disease (Disease or Syndrome)\tdown regulation of hemopoietic stem cell proliferation (negative regulation of stem cell proliferation)\tDS-GPA Score (Graded Prognostic Assessment)", + "output": "DS-GPA Score (Graded Prognostic Assessment)" + }, + { + "input": "Definition: Intellectual Product described as a question about other things that have bothered an individual lately.\nConcepts: Antithyroid agent (Hormonal Agents, Suppressant)\tANTISERUM, NEUTRALIZATION, RESPIRATORY SYNCYTIAL VIRUS (Indicator, Reagent, or Diagnostic Aid)\tOther Things That Have Bothered Lately (Clinical or Research Assessment Question)\tIMX101 vaccine (Immunologic Factor)\tCDISC ADAS-Cog - Word Recognition: Word 4 (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Other Things That Have Bothered Lately (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Medical Device described as clip appliers designed to deliver small atraumatic implantable clips for external occlusion of the fallopian tubes during laparoscopic procedures. These appliers may include a mechanism for single or multiple insertions of clips. Laparoscopic fallopian tube clip appliers are used for applying clips for permanent occlusion of the tubes, usually for sterilization purposes.\nConcepts: Cytoplasmic Antibodies, Antineutrophil (LABORATORY ABNORMALITIES)\tProvides discharge planning education to the patient and designated support person (Educational Activity)\tNCPDP Terminology (Intellectual Product)\tClip Appliers, Fallopian Tube, Laparoscopic (Medical Device)\tSTREPTONIGRIN (Antibiotics, Antineoplastic)", + "output": "Clip Appliers, Fallopian Tube, Laparoscopic (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable, allosteric Bcr-Abl tyrosine kinase inhibitor with potential antineoplastic activity. Designed to overcome resistance, ABL001 binds to the Abl portion of the Bcr-Abl fusion protein at a location that is distinct from the ATP-binding domain. This binding results in the inhibition of Bcr-Abl-mediated proliferation and enhanced apoptosis of Philadelphia chromosome-positive (Ph+) hematological malignancies. The Bcr-Abl fusion protein tyrosine kinase is an abnormal enzyme produced by leukemia cells that contain the Philadelphia chromosome.\nConcepts: Supranuclear ophthalmoplegia (Disease or Syndrome)\tGrade 1 Restlessness, CTCAE (Finding)\tSpermiogenesis, function (MALE REPRODUCTIVE FUNCTIONS AND SYMPTOMS)\tASCIMINIB (Pharmacologic Substance)\tBeaked nails (Finding)", + "output": "ASCIMINIB (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.\nConcepts: arterial insufficiency (Non-site specific necrosis and vascular insufficiency NEC)\tOcular Fluorophotometry (Fluorometry)\tAnimal Distributions (Social Behavior)\tglutamate receptor activity (Molecular Function)\tMotion Detector Device (Manufactured Object)", + "output": "glutamate receptor activity (Molecular Function)" + }, + { + "input": "Definition: BCR-ABL Fusion Gene described as a fusion gene that results from a chromosomal translocation t(9;22)(q34;q11) that fuses the 5' part of the BCR gene between exons 12 and 16 to the 5' side of exon 2 of the ABL1 gene. This rearrangement is associated with chronic myelogenous leukemia, acute lymphoblastic leukemia and acute myeloid leukemia.\nConcepts: Herpes Virus 6 DNA (Molecular Analysis)\tAllogeneic HAdV Antigen-specific T-cells (Allogeneic Lymphocyte)\tBCR-ABL1 Fusion Gene p210 (Gene or Genome)\tp100 Co-Activator (Transcription Regulatory Protein)\tcarbon tetrachloride (Pharmacologic Substance)", + "output": "BCR-ABL1 Fusion Gene p210 (Gene or Genome)" + }, + { + "input": "Definition: something described as a variation in the amino acid sequence for the granulocyte colony-stimulating factor receptor protein.\nConcepts: disorders, sleep (nervous system disorder)\tGCSFR Protein Variant (Gene Product Sequence Variation)\tmeta-cresol metabolism (Molecular Function)\tpositive regulation of FGF receptor signaling pathway of ureteric bud formation (positive regulation of fibroblast growth factor receptor signaling pathway)\tGrade 2 Atrioventricular Block First Degree, CTCAE (Finding)", + "output": "GCSFR Protein Variant (Gene Product Sequence Variation)" + }, + { + "input": "Definition: Immunotoxins described as an antibody-drug conjugate (ADC) composed of an antibody targeting CS1 (SLAMF7/CD319) that is conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), via a cathepsin-cleavable linker, with potential antineoplastic activity. Upon administration, the antibody moiety of azintuxizumab vedotin binds to CS1-expressing tumor cells and is internalized, thereby delivering MMAE intracellularly. Upon cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M checkpoint arrest and apoptosis in CS1-expressing tumor cells. CS1 is a cell surface glycoprotein belonging to the CD2 subset of the immunoglobulin superfamily (IgSF) and is expressed with high levels and prevalence on multiple myeloma (MM) cells.\nConcepts: Stimulators, Electromagnetic, Low-Intensity (Stimulators, Electromagnetic)\tStage IIIB Thymoma (Stage III Thymoma AJCC v8)\tPalmitates (Palmitic Acids)\tAzintuxizumab vedotin (Antineoplastic Antibody-Drug Conjugate)\tRadiation Overexposure (Output above Specifications)", + "output": "Azintuxizumab vedotin (Antineoplastic Antibody-Drug Conjugate)" + }, + { + "input": "Definition: Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v6 described as breast cancer with metastasis in 10 or more axillary lymph nodes, or in infraclavicular lymph nodes, or in clinically apparent ipsilateral internal mammary lymph nodes in the presence of 1 or more positive axillary lymph nodes; or in more than 3 axillary lymph nodes with clinically negative microscopic metastasis in internal mammary lymph nodes; or in ipsilateral supraclavicular lymph nodes.\nConcepts: pN3 Carcinoma of the Breast v6 (Finding)\tcell proliferation involved in compound eye morphogenesis (Cell Function)\tAIDS-Related Kaposi Sarcoma Overall Risk Group (AIDS-Related Kaposi Sarcoma Stage Finding)\tpM1c Carcinoma of Prostate (Prostate Cancer pM1 TNM Finding v6 and v7)\tReceived High Quality Care From Specialists (Clinical or Research Assessment Answer)", + "output": "pN3 Carcinoma of the Breast v6 (Finding)" + }, + { + "input": "Definition: GDS Questionnaire Question described as geriatric Depression Scale (GDS) Do you prefer to stay at home, rather than going out and doing new things?\nConcepts: GDS - Prefer to Stay Home (GDS Questionnaire Question)\tVisible Radiation (Natural Phenomenon or Process)\tW SYNDROME (Intellectual Disability)\tContinuous Performance Task (Research or Clinical Assessment Tool)\tIntraoperative Musculoskeletal Injury (Finding)", + "output": "GDS - Prefer to Stay Home (GDS Questionnaire Question)" + }, + { + "input": "Definition: something described as a steroid derivative characterized by the hydroxyl group in position C-3 of the steroid skeleton, elimination of carbon 24.2 of the alkyl substituent, and unsaturated bonds in position 5-6 of the B ring, and position 22-23 in the alkyl substituent. It is synthesized by several unicellular algae and some terrestrial plants.\nConcepts: intercellular canaliculus (Cellular conduit)\tBermuda Grass Pollen IgG4 (Immunoglobulin measurement)\tStudy Subject Ultrasound Report (Report)\tErgosta-5,22-dien-3-ol, (3beta,22E)- (phytosterols)\tForearm Injuries (Disorder of forearm)", + "output": "Ergosta-5,22-dien-3-ol, (3beta,22E)- (phytosterols)" + }, + { + "input": "Definition: Finding described as a circumscribed, fluid-containing, epidermal elevation generally considered less than 10mm in diameter at the widest point.\nConcepts: Deletion of Short Arm of Chromosome 1 (1p) Associated Meningioma (Meningioma)\tPremix for Medicated Feeding Stuff Dosage Form (Biomedical or Dental Material)\tEpithelial ependymoma (Ependymoma - category)\tvesicle (Finding)\tMATERIALS, REPAIR OR REPLACEMENT, PACEMAKER (Medical Device)", + "output": "vesicle (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a radioimmunoconjugate of humanized M195 monoclonal antibody (MoAb) conjugated with isotope yttrium 90. MoAb M195 is reactive with the cell surface antigen CD33, a glycoprotein found on myeloid leukemia blasts and early hematopoietic progenitor cells but not on normal stem cells. This radioimmunoconjugate emits beta particles that causes cytotoxicity in tumor cells and has both imaging and therapeutic uses.\nConcepts: nucleus lagging edge (cellular anatomical entity)\tM195 (Pharmacologic Substance)\tSPONDYLOCOSTAL DYSOSTOSIS 1, AUTOSOMAL RECESSIVE (Disease or Syndrome)\tmannosyl-glycoprotein 1,4-N-acetamidodeoxy-beta-D-glycohydrolase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)\tAutosomal dominant palmoplantar keratoderma and congenital alopecia (Ectodermal Dysplasia)", + "output": "M195 (Pharmacologic Substance)" + }, + { + "input": "Definition: multicellular organismal reproductive process described as the generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.\nConcepts: gamete generation (Organism Function)\tsn-glycerol-3-phosphate:ubiquinone oxidoreductase activity (glycerol-3-phosphate dehydrogenase activity)\tundef.misc.repro srvc narr r (Therapeutic or Preventive Procedure)\tHomeopathic remedy preparation training individual each 15 minutes (Preparing and/or dispensing and/or training services with or without ICD diagnosis)\tRefractory Hepatosplenic T-Cell Lymphoma (Neoplastic Process)", + "output": "gamete generation (Organism Function)" + }, + { + "input": "Definition: something described as this gene has no known function.\nConcepts: duodenal bleeding ulcer (Duodenal Diseases)\tHeart Failure Prompting Medical Attention Event (Finding)\tPRRC1 gene (Genes, Regulator)\tSynovectomy (Procedure on soft tissue)\tpico- (Metric Prefix)", + "output": "PRRC1 gene (Genes, Regulator)" + }, + { + "input": "Definition: Groove described as anatomical fissure between the ala of nose and skin of cheek.\nConcepts: 2B3-101 (Doxorubicin Preparation)\tregulation of interleukin-6 biosynthetic process (regulation of cytokine biosynthetic process)\tHS12GGAB (Immunologic Tests)\tThymoma, medullary, malignant (Neoplastic Process)\tNasobuccal fissure (Body Space or Junction)", + "output": "Nasobuccal fissure (Body Space or Junction)" + }, + { + "input": "Definition: Circuit Board Device described as a circuit board that has connections that are preapplied, usually added using photo-resist and acid etching techniques.\nConcepts: presynapse assembly (presynapse organization)\tNLRP1 inflammasome complex formation (Molecular Function)\tautologous ovarian tissue transplantation (Fertility Assessment and Management)\tDicentric Chromosome (Alteration of chromosome structure)\tPC (Printed Circuit) Board (Medical Device)", + "output": "PC (Printed Circuit) Board (Medical Device)" + }, + { + "input": "Definition: something described as the determination of the number of large unstained cells present in a sample.\nConcepts: PENIS NEOPL (Pelvic Neoplasms)\tLarge Unstained Cell Count (Blood Cell Count)\tmental retardation-scapuloperoneal muscular dystrophy-lethal cardiomyopathy syndrome (Disease or Syndrome)\tRange of Motion, Abduction (Diagnostic Procedure)\tFerrozine (Organic Chemical)", + "output": "Large Unstained Cell Count (Blood Cell Count)" + }, + { + "input": "Definition: something described as neuropsychiatric Inventory (NPI) Severity of the delusions.\nConcepts: elevation of calcium ion concentration in mitochondrion (Cell Function)\tCESTAT (Completion Status)\tNPI1-Delusions Severity (NPI Questionnaire Question)\tresponse to exogenous double-stranded RNA (Organism Function)\tregulation of fungal-type cell wall beta-glucan biosynthetic process (regulation of beta-glucan biosynthetic process)", + "output": "NPI1-Delusions Severity (NPI Questionnaire Question)" + }, + { + "input": "Definition: General Qualifier described as following the second position in an ordering or series; coming next after the second and just before the fourth in position.\nConcepts: connecting tubule development (nephron tubule development)\tThirdly (General Qualifier)\tFlatworms (Animals)\tAcquinite (LUNG IRRITANTS)\tAROM - Artificial rupture of membrane (Medical or surgical induction of labor)", + "output": "Thirdly (General Qualifier)" + }, + { + "input": "Definition: something described as the unit of measure for the result of the respiratory system assessment as originally received or collected.\nConcepts: Myxobolus, NOS (Myxosporea)\tREORRESU (Original Result Unit)\tWound Therapy Systems, Topical Oxygen, Normobaric (Medical Device)\tnrtrns educ.ndvdl ea.15min (Therapeutic or Preventive Procedure)\tt(6;9) (Cell or Molecular Dysfunction)", + "output": "REORRESU (Original Result Unit)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of DNA amplification.\nConcepts: PODCI Pediatric Parent-Reported Version - Friends Limited by: Fear (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tMSQL151 (MSQOL-54 Questionnaire Question)\tLymphoma, Giant Follicular (Lymphoma, Diffuse)\tMalignant Ito Cell Tumor (Neoplastic Process)\tregulation of DNA amplification (regulation of DNA biosynthetic process)", + "output": "regulation of DNA amplification (regulation of DNA biosynthetic process)" + }, + { + "input": "Definition: something described as disability Assessment for Dementia - Write and convey a telephone message adequately?\nConcepts: DAD0124 (Intellectual Product)\tCAMERA, TELEVISION, ENDOSCOPIC, WITH AUDIO (Medical Device)\t2-haloalkanoic acid dehalogenase activity (Molecular Function)\tLung Alveolar Epithelia (Alveolar wall)\tLuse bodies (Anatomical Abnormality)", + "output": "DAD0124 (Intellectual Product)" + }, + { + "input": "Definition: Changes in retinal vascular appearance described as a phenotypic variant of a group of inherited small vessel disorders known as retinal vasculopathy and cerebral leucodystrophy and characterised by progressive visual impairment, strokes and often associated with Raynaud phenomenon and migraine-like symptoms.\nConcepts: Venules (Body Part, Organ, or Organ Component)\tHereditary vascular retinopathy (Hereditary disorder of the visual system)\tp53 synthetic long peptide vaccine (Vaccines, Peptide)\tRobot (Device Component or Accessory)\tneutrophil mediated killing of gram-positive bacterium (neutrophil-mediated killing of bacterium)", + "output": "Hereditary vascular retinopathy (Hereditary disorder of the visual system)" + }, + { + "input": "Definition: something described as centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.\nConcepts: HsRINT-1 (Biologically Active Substance)\t3-Rhamnosyl-Glucosyl Quercetin (Organic Chemical)\tMultiple epiphyseal dysplasia with miniepiphyses (Disease or Syndrome)\tde novo centriole assembly involved in multi-ciliated epithelial cell differentiation (de novo centriole assembly)\tGranuloma annulare (Granulomatous disorder of the skin and subcutaneous tissue)", + "output": "de novo centriole assembly involved in multi-ciliated epithelial cell differentiation (de novo centriole assembly)" + }, + { + "input": "Definition: regulation of pyloric antrum smooth muscle contraction described as any process that decreases the frequency, rate or extent of any pyloric antrum smooth muscle contraction.\nConcepts: site tumour (Site of)\tnegative regulation of pyloric antrum smooth muscle contraction (negative regulation of gastro-intestinal system smooth muscle contraction)\tPericardiocenteses (Aspiration-action)\tspindle pole body separation (Cell Function)\textropion (Other disorders of eyelid)", + "output": "negative regulation of pyloric antrum smooth muscle contraction (negative regulation of gastro-intestinal system smooth muscle contraction)" + }, + { + "input": "Definition: Licensing Factor Gene described as this gene plays a role in regulation of the early steps of DNA replication.\nConcepts: Retropneumoperitoneum (Pathologic Processes)\tperianth development (Physiologic Function)\tCSS07-Idea, No Intent, No Plan-Life (Intellectual Product)\tCELL DIVISION CYCLE 18, S. POMBE, HOMOLOG-LIKE (Gene or Genome)\tion transmembrane transport (Transmembrane Transport)", + "output": "CELL DIVISION CYCLE 18, S. POMBE, HOMOLOG-LIKE (Gene or Genome)" + }, + { + "input": "Definition: Qualitative Concept described as a relationship between a defined repeating activity and one of the following that may trigger the repeating activity to stop, where all items are part of a global library:- another defined activity where the repeating activity stops if this other activity occurs- a defined observation result where the repeating activity stops if this observation result occurs- a defined criteria group where the repeating activity stops if this group logically evaluates to true based on its components Example: Continue repeating kidney dialysis until kidney transplant surgery. Continue performing a certain lab test weekly until the three-month checkup occurs. (target = another activity)Continue substance administration of drug X until the blood pressure is over some minimum threshold number. (target = observation result from another activity that is an observation)Continue substance administration of drug Y until the blood pressure is over some minimum threshold number and either the result of a certain lab test is positive or the subjects temperature is elevated, i.e. \"(A and (B or C))\".\nConcepts: PTAP1-Reciprocal Interval Self Trial (Paced Tapping Functional Test Question)\tregulation of steroid metabolic process (regulation of lipid metabolic process)\tDefined Repeat Activity Until Rule (Rule)\tpost-embryonic animal organ morphogenesis (post-embryonic animal morphogenesis)\t2: 225275619-225160374 (Chromosome 2 Physical Location)", + "output": "Defined Repeat Activity Until Rule (Rule)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 23,24-dihydrocucurbitacin + NAD(P)+ = cucurbitacin + NAD(P)H + H+.\nConcepts: Infliximab (Finding)\tNAD(P)H: cucurbitacin B delta23-oxidoreductase activity (Molecular Function)\tAbnormal dilatation of cervix before onset of labor (Abortion, Habitual)\tnegative regulation of hepatic stellate cell contraction (regulation of hepatic stellate cell contraction)\tmetabolite (Biologically Active Substance)", + "output": "NAD(P)H: cucurbitacin B delta23-oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as software designed to operate laboratory fermenters and bioreactors, control and monitor a limited number of their functions, and/or process data obtained while operating. This software is intended to work only with one or a few models of laboratory fermenters and bioreactors, usually from the same manufacturer. The software performs a variety of algorithms that permit managing and monitoring of the process. It establishes parameters and alarm set points, provides batch records, and obtains data needed for quality control and/or to audit the performance during a procedure. Laboratory fermenter/bioreactor software is not usually available separate from the equipment but may be updated (i.e., through the release of modified versions) during the life of the equipment; the software may be capable of interacting with laboratory and/or hospital information systems. Dedicated software intended for particular procedures used in microbiology and/or plant, animal, or human cell fermentation procedures is also available.\nConcepts: Constipation/Impaction Management (Therapeutic or Preventive Procedure)\tnoradrenergic group Acg (Cell)\tSoftware, Laboratory Fermenter/Bioreactors (Intellectual Product)\t2-hydroxy-3-methylbenzalpyruvate hydratase-aldolase activity (aldehyde-lyase activity)\tregulation of histone phosphorylation (Organism Function)", + "output": "Software, Laboratory Fermenter/Bioreactors (Intellectual Product)" + }, + { + "input": "Definition: Psychology, Social described as behavior directed towards society, or taking place between members of the same species. Occurs predominantly, or only, in individuals that are part of a group.\nConcepts: Functional Incontinence Of Urine (Urinary Elimination Component)\tbehaviour social (attitude and behavior)\tPRO1280 (SUFU gene)\tchemotherapeutics brentuximab vedotin (CD30-directed Immunoconjugate)\tUnit of Electrical Conductance (Quantitative Concept)", + "output": "behaviour social (attitude and behavior)" + }, + { + "input": "Definition: something described as any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.\nConcepts: Bronchopulmonary segment, NOS (Body Location or Region)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2a Failure to Thrive (Intellectual Product)\tMean Calorie (Quantitative Concept)\tMITOTIC FIGURES, INCREASED (Finding)\tregulation of fungal-type cell wall organization (regulation of cell wall organization or biogenesis)", + "output": "regulation of fungal-type cell wall organization (regulation of cell wall organization or biogenesis)" + }, + { + "input": "Definition: Genetic Function described as the chemical reactions and pathways involving the addition of a 5-carbamoylmethyl group to a uridine residue in RNA.\nConcepts: 5-carbamoylmethyl uridine residue modification (tRNA methylation)\tbeta-catenin destruction complex (Intracellular Signaling Peptides and Proteins)\tIgbo (Language)\tReceptors, Histamine (Biogenic Amine Receptors)\tReceiver Device (Device Component or Accessory)", + "output": "5-carbamoylmethyl uridine residue modification (tRNA methylation)" + }, + { + "input": "Definition: Stomach and Omentum described as lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.\nConcepts: UPD148 (Intellectual Product)\tINS316 (Nucleic Acid, Nucleoside, or Nucleotide)\tMacrosaccadic oscillations (Eye)\tMucosa, Gastric (Stomach)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ADRB2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Mucosa, Gastric (Stomach)" + }, + { + "input": "Definition: something described as the year in which an individual quit smoking.\nConcepts: Hurthle Cell Carcinoma of Thyroid Gland (Hurthle Cell Tumor)\ttherapy ultrasonic (Therapeutic procedure)\tPartial duplication of phalanx of the 2nd toe (Anatomical Abnormality)\tFAC01821 (Intellectual Product)\tSmoking Quit Year (Temporal Concept)", + "output": "Smoking Quit Year (Temporal Concept)" + }, + { + "input": "Definition: Nervous System Physiological Processes described as the ability of the BRAIN to suppress neuronal responses to external sensory inputs, such as auditory and visual stimuli. Sensory filtering (or gating) allows humans to block out irrelevant, meaningless, or redundant stimuli.\nConcepts: Alphachloralose (chloral hydrate)\tFiltering, Sensory (Perception)\tfexofenadine (Histamine H1 Antagonists, Non-Sedating)\trecurrent hairy cell leukemia (Refractory Chronic Leukemia)\tmelanism (Disease of Skin and Appendages)", + "output": "Filtering, Sensory (Perception)" + }, + { + "input": "Definition: cellular catabolic process described as the chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue.\nConcepts: Fibrotic muscularis propria (Anatomical Abnormality)\tLipooxygenase Inhibitor (Enzyme Inhibitor Drugs)\tHigh frequency (Finding)\tpeptidyl-diphthine degradation (peptidyl-diphthine metabolic process)\tNCI CTEP Simple Disease Classification Ovarian Cancer (excluding Ovarian Germ Cell Cancer) Sub-Category Terminology (NCI CTEP SDC Reproductive System Neoplasm, Female Category Terminology)", + "output": "peptidyl-diphthine degradation (peptidyl-diphthine metabolic process)" + }, + { + "input": "Definition: Eukaryote described as an eight-armed cephalopod mollusk belonging to the order Octopoda. It includes the octopus as food.\nConcepts: CAMPIMETER, STEREO, BATTERY-POWERED (Medical Device)\tRelated to Cancer (Finding)\tdiacylglycerol acyltransferase activity (acylglycerol O-acyltransferase activity)\tMetachronous Osteosarcoma of the Bone (Metastatic osteosarcoma)\tOctopus (Eukaryote)", + "output": "Octopus (Eukaryote)" + }, + { + "input": "Definition: Multivalent Vaccines described as an polyvalent vaccine used to prevent infection by the bacterium Streptococcus pneumoniae. Pneumococcal polyvalent vaccine contains higly purified capsular antigens from the 23 most prevalent or invasive pneumococcal types of Streptococcus pneumoniae to ensure cross-protection. Following vaccination, protective capsular type-specificantibody levels typically develop by the third week; serotype-specific antibody levels generally decline after 5-10 years. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1643\" active clinical trials using this agent.\nConcepts: PNEUMOCOCCAL POLYSACCHARIDE VACCINE (Immunologic Factor)\tSquamous Cell Carcinoma of Submandibular Gland (Carcinoma of submandibular gland)\tlongitudinal study (Cohort Studies)\tEssential fatty acid (NCI Thesaurus Property)\tT25FW1-Did Patient Wear AFO (Intellectual Product)", + "output": "PNEUMOCOCCAL POLYSACCHARIDE VACCINE (Immunologic Factor)" + }, + { + "input": "Definition: Abnormal subarachnoid space morphology described as intracranial hemorrhage into the subarachnoid space.\nConcepts: Seminiferous Epithelium (Multilaminar epithelium)\tSummary (Mean) QRS Duration (ECG Measurement)\tHemorrhage;subarachnoid (PLATELET,BLEEDING & CLOTTING DISORDERS)\tglecaprevir and pibrentasvir (Antiviral Agents)\tSLV (Central America)", + "output": "Hemorrhage;subarachnoid (PLATELET,BLEEDING & CLOTTING DISORDERS)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the organisms that are assigned to the Mycobacterium tuberculosis species in a biological specimen.\nConcepts: protein 4.1 (Receptor)\tChromosome 18 Distal Arm (Gene Deletion)\tAutomated count (Measurement)\t2'-hydroxyisoflavone reductase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tMTB (Laboratory Procedure)", + "output": "MTB (Laboratory Procedure)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the Borrelia burgdorferi IgG antibody in a biological specimen.\nConcepts: Apical lateral zone of myocardium of left ventricle (Myocardium of region of apical zone of left ventricle)\tSDTM-DURS (Intellectual Product)\tsprtlnrse assist ea.15min (Spiritual nursing care)\tperiplasmic space organization (Cell Function)\tSerum IgG Lyme Antibody Test (Laboratory Procedure)", + "output": "Serum IgG Lyme Antibody Test (Laboratory Procedure)" + }, + { + "input": "Definition: Creatinine Clearance Formula described as a formula to estimate creatinine clearance that takes into account sex, age, weight, and serum creatinine (SCr). CCr=(140 - Age) x Wgt (Kg) / 72xCrt (mg/dL) x 1 (if M) or 0.85 (if F), for conventional units. CCr=(140 - Age) x Wgt (Kg) / 72xCrt (MCMOL/L) x 88.4 x 1 (if M) or 0.85 (if F) [If Wgt is in lbs; Wgt (Kg) = Wgt (lbs) x 0.45], for SI units. (Cockcroft, D.W. and M.H. Gault. Prediction of creatinine clearance from serum creatinine. Nephron. 1976. 16(1):31-41.)\nConcepts: Yeasts (Fungi.yeastlike)\tTEST REAGENTS FOR METHYL ALCOHOL (Indicator, Reagent, or Diagnostic Aid)\tCockcroft-Gault Formula (Clearance calculation formula)\tPedsQL Neuromuscular Module Version 3.0 Young Child Report - Get Sores and/or Rashes (Intellectual Product)\tNo shortness of breath (Clinical or Research Assessment Answer)", + "output": "Cockcroft-Gault Formula (Clearance calculation formula)" + }, + { + "input": "Definition: something described as lack of a palpable nasal cartilage.\nConcepts: TPM4/ALK Fusion Protein (Fusion protein)\tContinuous Thread Metal Container Closure (Container Closure System)\tDefined Composition Relationship Pause Quantity (Pause Quantity)\tPMO AVI-4126 (Pharmacologic Substance)\tAbsent nasal cartilage (Abnormality of the nasal cartilage)", + "output": "Absent nasal cartilage (Abnormality of the nasal cartilage)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Protein described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids (e.g., plasma) to determine the level of the protein procalcitonin (PCT), a prohormone of the hormone calcitonin, that can be produced by several cell types and many organs and circulates in plasma. Procalcitonin levels increase rapidly (values in normal people are usually below 0.1 ng/mL) in response to pro-inflammatory stimuli, in particular those produced by bacterial products. The evaluation of PCT concentration facilitates the assessment of the patient's risk of progression to severe sepsis and septic shock; localized infections, allergic disorders, transplant rejection, and other diseases do not usually induce significant increases in the PCT value above 0.5 ng/mL.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Protein, Procalcitonin (IVD Test Reagent/Kits, Immunoassay, Protein)\tCytarabine-Daunorubicin-Mercaptopurine-Prednisolone (Regimen Used to Treat Acute Myeloid Leukemia)\tJPS 17b node (Structure of inferior pancreaticoduodenal lymph node)\tB Cell Surface Antigen CD40 (Amino Acid, Peptide, or Protein)\tNeed Certificate (Governmental or Regulatory Activity)", + "output": "IVD Test Reagent/Kits, Immunoassay, Protein, Procalcitonin (IVD Test Reagent/Kits, Immunoassay, Protein)" + }, + { + "input": "Definition: intermediate filament-based process described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins.\nConcepts: Saururus cernuus / lizard's tail (Homeopathic remedies letter S)\tNephrogenic Adenoma of the Urethra (Non-Neoplastic Urethra Disorder)\tNumber of Frames (Quantitative Concept)\tGrade 1 Jejunal stenosis (Finding)\tintermediate filament cytoskeleton organisation (Cell Function)", + "output": "intermediate filament cytoskeleton organisation (Cell Function)" + }, + { + "input": "Definition: Congenital Abnormality described as syndactyly with fusion of fingers one to five (complete syndactyly of all fingers of the hand).\nConcepts: Chemical Interference (DNA Footprinting)\tPrevotella (Bacterium)\tDental Staff (Dentistry)\tWebbed 1st-5th fingers (Congenital Abnormality)\tW - watt (SI unit of power)", + "output": "Webbed 1st-5th fingers (Congenital Abnormality)" + }, + { + "input": "Definition: Renal obstructive disorders described as blockage of urine flow from the renal pelvis to the proximal ureter.\nConcepts: Abnormality of the hypothalamus-pituitary axis (Anatomical Abnormality)\tDENT FEAR (Phobia, Specific)\tprotein localisation to cytoplasmic microtubule plus-end (Cell Function)\tUreteropelvic Junction Obstruction (Urinary Bladder)\tBRUCELLA CANIS (Bacterium)", + "output": "Ureteropelvic Junction Obstruction (Urinary Bladder)" + }, + { + "input": "Definition: Molecular Function described as catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears.\nConcepts: Mechanistic Target of Rapamycin Gene Rearrangement (Cell or Molecular Dysfunction)\tBROTHER, BIOLOGICAL MATERNAL HALF (Maternal Half Sibling)\tintramolecular isomerase activity, transposing C=C bonds (Molecular Function)\tRespiratory Therapist, Certified (Professional or Occupational Group)\tOvalocytosis (Abnormal Hematology Test Result)", + "output": "intramolecular isomerase activity, transposing C=C bonds (Molecular Function)" + }, + { + "input": "Definition: something described as an extension of the peritoneum between the uterus and the rectum in females, which is formally bounded thusly: anteriorly by the uterus and posterior fornix of the vagina; posteriorly by the rectum; inferiorly by the peritoneal rectovaginal fold.\nConcepts: sophorosyloxydocosanoate biosynthesis (Molecular Function)\tmyxosarcoma (Neoplastic Process)\tdouglas' cul-de-sac (Pelvic peritoneal cavity)\tGASTRIC FLUID (Body Substance)\tINTERNATIONAL STATIS CLASS DIS RELAT HEALTH PROBLEMS (Classification)", + "output": "douglas' cul-de-sac (Pelvic peritoneal cavity)" + }, + { + "input": "Definition: Occipital lobe described as the major convolution on the ventral surface of the occipital lobe. Identified by dissection, in the human it is separated from the isthmus of the cingulate gyrus rostrally by the anterior calcarine sulcus, from the cuneus dorsally by the calcarine sulcus, and from the fusiform gyrus laterally by the collateral sulcus. ( Duvernoy-1992; Ono-1990 ). The boundaries in the macaque are similar except that it is separated from the inferior occipital gyrus caudally by the occipitotemporal sulcus ( Martin-2000 ). It has no topological equivalent in the smooth cerebral cortex of the rat or mouse ( NeuroNames ).\nConcepts: Gyrus occipitotemporalis medialis (Entire occipital lobe gyrus)\tPHARM EPIDEMIOL (Biomedical Occupation or Discipline)\tSestrin 3 (Amino Acid, Peptide, or Protein)\tCKD-EPI Creatinine-Cystatin C Formula (Statistical Technique)\tTRPTRG (Trypsin measurement)", + "output": "Gyrus occipitotemporalis medialis (Entire occipital lobe gyrus)" + }, + { + "input": "Definition: Mood Stabilizers described as a stable coordination compound comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex dissociates to the valproate ion in the gastrointestinal tract. This agent binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. Divalproex may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28996\" active clinical trials using this agent.\nConcepts: Grade 1 Atrioventricular block first degree (Finding)\tMIRLET7B (MicroRNA Gene)\tSemisodium Valproate (Drugs used in migraine prophylaxis)\trespiratory disorder chemotherapy (Therapeutic or Preventive Procedure)\tHAI0101 (HAI Functional Test Question)", + "output": "Semisodium Valproate (Drugs used in migraine prophylaxis)" + }, + { + "input": "Definition: Orbital Sarcoma Clinical Distant Metastasis TNM Finding v8 described as orbital sarcoma with no distant metastasis.\nConcepts: Orbital Sarcoma cM0 TNM Finding v8 (Orbital Sarcoma Clinical Distant Metastasis TNM Finding v8)\th*mg/mL/g (Quantitative Concept)\tShort outermost bone of ring finger (Short 4th finger)\tFETAL CIRC PERSISTENT (Perinatal cardiovascular disorders)\tD-arabinitol dehydrogenase, D-xylulose forming (NADP+) activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "Orbital Sarcoma cM0 TNM Finding v8 (Orbital Sarcoma Clinical Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: Median nerve and its branches described as a nerve extending from the brachial plexus traveling the length of the arm/thoracic limb, which innervates some flexor muscles of the arm/forelimb and the skin on the palmar aspect of the carpus, metacarpus and digits.\nConcepts: Median Nerve (Non-Autonomic Spinal Nerves)\tSodium 2-Mercaptoethane Sulfonate (Organic sulfonic acid)\tSoftware, Laboratory Analysis (Computer software)\tLugano Lymphoma Response Classification Complete Remission by PET (Lugano Lymphoma Response Classification)\t5-S-cysteinyldopa (Amino Acids)", + "output": "Median Nerve (Non-Autonomic Spinal Nerves)" + }, + { + "input": "Definition: something described as the regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).\nConcepts: Stage IB Carcinoma of the Vulva AJCC v6 (Neoplastic Process)\tAllergic Rhinitis (Inflammatory disorder of the respiratory tract)\tNM 004333.4:c.1789 1790delCTinsTC (BRAF Exon 15 Mutation)\tregeneration (anatomical structure development)\tHealth Literacy (Mental Process)", + "output": "regeneration (anatomical structure development)" + }, + { + "input": "Definition: Organic Chemical described as a bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1123\" active clinical trials using this agent.\nConcepts: 1,7-Heptanediyl Ester Sulfamic Acid (Organic Chemical)\tp38 mitogen-activated protein kinase inhibitor LY3007113 (Pharmacologic Substance)\tchromosome, centromeric inner repeat region (Region of chromosome)\tforeign bodies (Disease)\tPROTEIN S DEFIC (Blood Protein Disorders)", + "output": "1,7-Heptanediyl Ester Sulfamic Acid (Organic Chemical)" + }, + { + "input": "Definition: something described as the standard deviation of the subject's bone mineral density score in comparison to the normal bone mineral density of a healthy 30-year old adult.\nConcepts: DefinedProcedure.approachAnatomicSiteCode (Intellectual Product)\tpolyol catabolic process (polyol metabolic process)\tmyosin XII complex (Cell Component)\tRefrigerators, Morgue, End-Opening (Medical Device)\tBMDT (Finding)", + "output": "BMDT (Finding)" + }, + { + "input": "Definition: something described as a nanoparticle albumin-bound formulation of a thiocolchicine dimer, an inhibitor of both microtubule and topoisomerase I (TOP1), with antineoplastic and vascular disrupting activities. Upon administration of nanoparticle albumin-bound thiocolchicine dimer nab-5404, this agent binds to tubulin and inhibits its polymerization, which blocks mitotic spindle formation and leads to cell cycle arrest and tumor endothelial cell apoptosis. This disrupts the tumor vasculature and leads to tumor necrosis. In addition, nab-5404 binds to topoisomerase I (TOPI) and inhibits its activity. This results in the inhibition of the repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. The nanoparticle albumin-based formulation permits the albumin-mediated endocytosis of the thiocolchicine dimer by tumor cells and endothelial cells.\nConcepts: Hypoattenuation (Radiologic finding)\tarea 10v (Body Location or Region)\tnab-Thiocolchicine Dimer (Organic Chemical)\tConcentration After the Nth Dose by Body Mass Index (Quantitative Concept)\tInadequate molybdenum intake (Inadequate mineral intake)", + "output": "nab-Thiocolchicine Dimer (Organic Chemical)" + }, + { + "input": "Definition: Psychiatric therapeutic procedure described as an integrated approach to psychotherapy that combines the techniques of cognitive and behavior therapy.\nConcepts: middle ear; polyp (Ear lesion)\tCongenital anomaly of lens (Congenital anomaly of head)\tCOGNITIVE BEHAVIOR THER (psychiatric therapy approach)\tIGF1 Deficiency (Disease or Syndrome)\tFIGO Stage IA1 Cervix Uteri Carcinoma (Neoplastic Process)", + "output": "COGNITIVE BEHAVIOR THER (psychiatric therapy approach)" + }, + { + "input": "Definition: Investigations, CTCAE described as a finding based on laboratory test results that indicate abnormal levels of growth hormone in a biological specimen.\nConcepts: regulation of interleukin-27-mediated signalling pathway (Molecular Function)\tvortex veins (Tributary of superior ophthalmic vein)\tNon-Solid Ground-Glass Pulmonary Nodule (Finding)\tmuscle tissue (Tissue)\tGrowth Hormone Abnormal, CTCAE (Investigations, CTCAE)", + "output": "Growth Hormone Abnormal, CTCAE (Investigations, CTCAE)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the Expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Formularies, Hospital as Topic (Intellectual Product)\tBCL2-associated athanogene protein, human (Amino Acid, Peptide, or Protein)\tImplements clinical pathway (Health Care Activity)\tIndifferent Gonad (Other Embryologic Structure)\tExpanded Disability Rating Scale - Postacute Interview Caregiver Version Questionnaire Test Code (Intellectual Product)", + "output": "Expanded Disability Rating Scale - Postacute Interview Caregiver Version Questionnaire Test Code (Intellectual Product)" + }, + { + "input": "Definition: Finding described as incisional separation, local care (e.g., suturing) or medical intervention indicated\nConcepts: Grade 2 Wound dehiscence (Wound Dehiscence, CTCAE)\tupregulation of TORC2 signaling (positive regulation of TOR signaling)\tC-MOPP (Therapeutic or Preventive Procedure)\tAmbenonium Chloride Tetrahydrate (Pharmacologic Substance)\tMinimally Invasive Thymoma (Neoplastic Process)", + "output": "Grade 2 Wound dehiscence (Wound Dehiscence, CTCAE)" + }, + { + "input": "Definition: something described as collecting an autogenous sample specimen other than blood from a client/patient. Service is billed per specimen collection.\nConcepts: Blinatumomab (Antibodies, Neoplasm)\tGAIA Level 2 Antepartum Stillbirth (GAIA Stillbirth Level of Diagnostic Certainty)\tEMG: decremental response of CMAP to repetitive nerve stimulation (Finding)\tAutogenous sample specimen each specimen collection (Laboratory Procedure)\tMuscle fiber tubular inclusions (Muscle fiber cytoplasmatic inclusion bodies)", + "output": "Autogenous sample specimen each specimen collection (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a unit of measure representing the intensity of an electrical signal or sound which is equal to ten times the logarithm of the ratio of two signals.\nConcepts: BNLNUM (Number of lesions)\tCryptococcoses (Mycoses)\tbepridil hydrochloride (Organic Chemical)\tDecibel (Quantitative Concept)\tDRRI-2 - C: Not Allowed to Get Job Done (Intellectual Product)", + "output": "Decibel (Quantitative Concept)" + }, + { + "input": "Definition: something described as an acute inflammatory response to non-antigenic stimuli such as heat or physical trauma.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ALMS1 (Medical Device)\tacute inflammatory response to non-antigenic stimulus (Pathologic Function)\tRefsum Disease Gene Mutation Panel Reagents (Medical Device)\tGustatory Hyperhidrosis (Body Temperature States and Skin Functions)\t1H-Isoindolium, 4,5,6,7-tetrachloro-2,3-dihydro-2-methyl-2-(2-(trimethylammonio)ethyl)-, dichloride (Antihypertensive Agents)", + "output": "acute inflammatory response to non-antigenic stimulus (Pathologic Function)" + }, + { + "input": "Definition: Gene or Genome described as human HACL1 wild-type allele is located in the vicinity of 3p25.1 and is approximately 41 kb in length. This allele, which encodes 2-hydroxyacyl-CoA lyase 1 protein, plays a role in lipid metabolism.\nConcepts: Chimeric Monoclonal Antibody 81C6 (Immunologic Factor)\tAudit (Administrative Activity)\tSuspicious (General Qualifier)\tGC/MS-EI (Laboratory Procedure)\tHACL1 wt Allele (Gene or Genome)", + "output": "HACL1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Pharmacologic Substance described as compounds that inhibit SODIUM-GLUCOSE TRANSPORTER 2. They lower blood sugar by preventing the reabsorption of glucose by the kidney, and are used in the treatment of TYPE 2 DIABETES MELLITUS.\nConcepts: Multitest skin test (Test of cell-mediated immunity)\tAntitumor B KAC-a (Dietary Supplements)\tHyperuricaemia, anaemia, renal failure syndrome (Disease or Syndrome)\tSGLT2 Inhibitors (Pharmacologic Substance)\tVitamin K 2 (Pharmacologic Substance)", + "output": "SGLT2 Inhibitors (Pharmacologic Substance)" + }, + { + "input": "Definition: Blood Coagulation Disorders described as an abnormality that refers to mutation of factor V Leiden, which is a variant of human factor V. It results in thrombophilia, deep vein thrombosis, and a slightly increased risk of miscarriage.\nConcepts: CMOAT2 (Transport Protein Gene)\tMixed Germ Cell-Sex Cord-Stromal Neoplasm (Testicular Sex Cord-Gonadal Stromal Tumor, Mixed Forms)\tVena saphena parva (Structure of vein of lower extremity)\tFactor 5 Leiden mutation (Rare Non-Neoplastic Disorder)\tLabor and employment policies (Governmental or Regulatory Activity)", + "output": "Factor 5 Leiden mutation (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Racial group described as denotes a person whose ancestry is in the country of New Zealand.\nConcepts: HER1 c.866C>T (Cell or Molecular Dysfunction)\tNew Zealander (Racial group)\tIGF Binding Protein 5 (Insulin-Like Growth-Factor-Binding Proteins)\tImpaired (Degree findings)\tKNOWLEDGE (Finding)", + "output": "New Zealander (Racial group)" + }, + { + "input": "Definition: Finding described as an auscultated finding describing a sharp, high-frequency sound heard during auscultation of the thorax caused by valvar prolapse or stenosis.\nConcepts: Systolic Click (Finding)\tVessel Patency Indicator (Finding)\tsideretin biosynthesis (Molecular Function)\tAsylum Seeker, Political (Population Group)\tAutosomal recessive leukoencephalopathy, ischemic stroke, retinitis pigmentosa syndrome (Disease or Syndrome)", + "output": "Systolic Click (Finding)" + }, + { + "input": "Definition: something described as an inherited retinal disease subtype in which the rod photoreceptors appear to be more severely affected than the cone photoreceptors. Typical presentation is with nyctalopia (due to rod dysfunction) followed by loss of mid-peripheral field of vision, which gradually extends and leaves many patients with a small central island of vision due to the preservation of macular cones.\nConcepts: Nilutamida (Drug allergens)\tNon-Commercial Sources (Classification)\tRod cone dystrophy (Disease or Syndrome)\tCongenital thyroid hypoplasia (Congenital hypothyroidism without goiter)\tFood (Food)", + "output": "Rod cone dystrophy (Disease or Syndrome)" + }, + { + "input": "Definition: Sclerosis of 2nd finger phalanx described as uneven (irregular) increase in bone density of one or more of the phalanges of the 2nd finger.\nConcepts: micrococcus (BACTERIA AND RICKETTSIAE)\tUneven increase in bone density in index finger bone (Finding)\tnegative regulation of inhibitory G protein-coupled receptor phosphorylation (Molecular Function)\tType II bone height of edentulous mandible (Finding of bone height of edentulous mandible)\tAsparagus officinalis, homeopathic preparation (Organic Chemical)", + "output": "Uneven increase in bone density in index finger bone (Finding)" + }, + { + "input": "Definition: Classification described as a group forming a type within a larger type.\nConcepts: EPIC-26 - Increased Frequency of Bowel Movements (EPIC-26 Questionnaire Question)\tInitial Concentration (Quantitative Concept)\tup regulation of embryonic skeletal joint development (regulation of embryonic skeletal joint development)\tsubtypes (Conceptual Entity)\t6: 31658181-31656314 (Chromosome 6 Physical Location)", + "output": "subtypes (Conceptual Entity)" + }, + { + "input": "Definition: Cervical Cancer by AJCC v7 Stage described as stage II includes: II (T2, N0, M0); IIA (T2a, N0, M0); IIA1 (T2a1, N0, M0); IIA2 (T2a2, N0, M0); IIB (T2b, N0, M0); T2: Cervical carcinoma invades beyond uterus but not to pelvic wall or to lower third of vagina. T2a: Tumor without parametrial invasion. T2a1: Clinically visible lesion 4.0 cm or less in greatest dimension. T2a2: Clinically visible lesion more than 4.0 cm in greatest dimension. T2b: Tumor with parametrial invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Ear neoplasm (Ear structure)\tEmbolic and thrombotic events, venous (Classification)\tDRRI1-A: Witnessed Someone Assaulted (DRRI-2 Questionnaire Question)\tStage II Cervical Cancer (Cervical Cancer by AJCC v7 Stage)\tWay-finding Hospital Information Systems (Manufactured Object)", + "output": "Stage II Cervical Cancer (Cervical Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: something described as a coded value specifying the time recurrence by which an adverse event occurs.\nConcepts: Adverse Event Occurrence Pattern Code (Occurrence Pattern Code)\tNeuropeptide Receptors (Receptors, Cell Surface)\tProstate Carcinoma cT2b TNM Finding v8 (Prostate Cancer cT2 TNM Finding v8)\tMobiluncus curtisii [Ambiguous] (Bacterium)\tAnticachexia Agent (Pharmacologic Substance)", + "output": "Adverse Event Occurrence Pattern Code (Occurrence Pattern Code)" + }, + { + "input": "Definition: something described as naturally occurring or synthetic substances that inhibit or retard oxidation reactions. They counteract the damaging effects of oxidation in animal tissues.\nConcepts: Recurrent Cancer of Skin (stage/cell type, skin cancer)\tMetanephric Stromal Tumor (Metanephric Tumor)\t2,3-dihydroxy DDT 1,2-dioxygenase activity (Molecular Function)\tAnti Oxidant (medications and vaccines)\tGestagens (Endocrine system)", + "output": "Anti Oxidant (medications and vaccines)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a hemipelvectomy with the resection confined to the periacetabulum.\nConcepts: Rehmanniae / sheng di / shu di huang (Oriental herbs and natural substances letter R)\tEsophageal squamous cell carcinoma stage IV (Squamous cell carcinoma, metastatic)\tanatomical structure arrangement (AGE AND GROWTH PERIODS)\tHemipelvectomy Type II (Hemipelvectomy)\tPRACTICE ASSOC INDIVIDUAL (Health Care Related Organization)", + "output": "Hemipelvectomy Type II (Hemipelvectomy)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) Because of your health condition, in the past 30 days, how much difficulty did you have in: Taking care of your household responsibilities?\nConcepts: Grade 2 Sinus tachycardia (Sinus Tachycardia, CTCAE 3.0)\tCoping Component (Diagnosis)\tHebrides (Geographic Area)\tFKSI-15 Questionnaire Question (Intellectual Product)\tWHODAS 2.0 36-item Version Interviewer-administered - Care of Household Responsibilities (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)", + "output": "WHODAS 2.0 36-item Version Interviewer-administered - Care of Household Responsibilities (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: cognitive processes described as constant preoccupation with particular thoughts which may provoke anxiety and distress. Can be associated with obsessive compulsive disorder and depression.\nConcepts: Rumination (Mental Process)\tPQL0308 (Intellectual Product)\tIVD Test Reagent/Kits, Clinical Chemistry, Protein, Total, Serum (IVD Test Reagent/Kits, Clinical Chemistry, Protein, Total)\tQS-NSCLC-SAQ Version 1.0 TESTCD (CDISC Questionnaire Terminology)\tSeparator (Medical Device)", + "output": "Rumination (Mental Process)" + }, + { + "input": "Definition: Blood and tissue flagellate described as a species of parasitic trypanosomatid protozoa in the family Trypanosomatidae. L. donovani causes both visceral and dermal leishmaniasis. This species is the primary cause of visceral leishmaniasis in the Indian subcontinent and East Africa.\nConcepts: Influenza in Human (Orthomyxoviridae Infections)\tGanetespib (Pharmacologic Substance)\tCervical endometriosis (Abnormality of the uterine cervix)\tLeishmania leishmania donovanus (Eukaryote)\tCorticothalamic fibres (Set of neuraxis fibers)", + "output": "Leishmania leishmania donovanus (Eukaryote)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the mitral regurgitant jet area to left atrial area.\nConcepts: Melanoma of the Conjunctiva pTX TNM Finding v7 (Finding)\tc.3909C>G (Finding)\timmunology laboratory test (Immunologic Tests)\tMRGJALA (Cardiovascular finding)\tBladder Urothelial Dysplasia (Bladder Non-Invasive Urothelial Neoplasm)", + "output": "MRGJALA (Cardiovascular finding)" + }, + { + "input": "Definition: something described as general or unspecified injuries involving the UPPER ARM and the FOREARM.\nConcepts: G1/S host cell cycle checkpoint dysregulation by virus (Cell Function)\tSwr1 complex (INO80-type complex)\tgrants (Quantitative Concept)\tC-Reactive Protein Level Greater than or Equal to 3 Milligrams per Liter (Laboratory or Test Result)\tInjury of upper limb (Disorder of upper extremity)", + "output": "Injury of upper limb (Disorder of upper extremity)" + }, + { + "input": "Definition: something described as mitotic spindle assembly checkpoint protein MAD2B (211 aa, ~24 kDa) is encoded by the human MAD2L2 gene. This protein plays a role in DNA repair and the mitotic spindle assembly checkpoint.\nConcepts: MAD2-Like Protein 2 (Biologically Active Substance)\tMPAI125 (MPAI-4 Questionnaire Question)\tMIRN127 (Gene or Genome)\tPAI1 (Protein or Enzyme Type Measurement)\tDisease of rectum, NOS (Disease or Syndrome)", + "output": "MAD2-Like Protein 2 (Biologically Active Substance)" + }, + { + "input": "Definition: Structure of half of brain lateral to midsagittal plane described as groups of cells embedded in the myelinated tracts of the basal pons. They are found in the human ( Carpenter-1983 ), the macaque ( Martin-2000 ), the rat ( Swanson-2004 ) and the mouse ( Hof-2000 ). Functionally they belong to the postcerebellar and precerebellar nuclei of the behavior control column ( Swanson-2004 ).\nConcepts: HLS2 (Biologically Active Substance)\tNuclei pontis (Structure of half of brain lateral to midsagittal plane)\tPostpartum complication (Complication)\tmolecular weight (Chemistry, Physical)\tEncephalomyelitis Virus, Western Equine (Virus)", + "output": "Nuclei pontis (Structure of half of brain lateral to midsagittal plane)" + }, + { + "input": "Definition: Estrogen Therapy described as the administration of estrogen, especially in postmenopausal women, to relieve menopausal symptoms and to protect against osteoporosis and heart disease.\nConcepts: American Public Health Association (Societies)\tneurotoxin (Poisons)\tESTROGEN REPLACEMENT THERAPY (Hormone replacement therapy)\tPropantheline (Xanthenes)\tPREGN UNPLANNED (Patient currently pregnant)", + "output": "ESTROGEN REPLACEMENT THERAPY (Hormone replacement therapy)" + }, + { + "input": "Definition: Dietary Supplements described as a dietary supplement containing coffee, with potential gastrointestinal (GI) tract stimulating activity. Following consumption of the dietary supplement, the coffee may both stimulate peristalsis and increase bowel movement. The supplement may also stimulate the central nervous system, suppress appetite and cause weight loss. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C113662\" active clinical trials using this agent.\nConcepts: route of administration nasogastric (Functional Concept)\tdownregulation of antigen processing and presentation of peptide antigen via MHC class II (negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II)\tCoffee Dietary Supplement (Pharmacologic Substance)\tRecorders, Graphic, Gas, Anesthesia (Manufactured Object)\tpeptide library (Amino Acid Sequence)", + "output": "Coffee Dietary Supplement (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as human PYCARD wild-type allele is located within 16p12-p11.2 and is approximately 2 kb in length. This allele, which encodes apoptosis-associated speck-like protein containing a CARD protein, is involved in the modulation of both caspase activation and apoptosis.\nConcepts: Has BoSS (Qualitative Concept)\tTMS (Gene or Genome)\tmalignant steroid cell tumor of ovary (Ovarian Steroid Cell Tumor, Not Otherwise Specified)\tCongenital ossification of sutures of skull (congenital oral/facial/cranial defect)\tMedicare Beneficiary Identification Number (Intellectual Product)", + "output": "TMS (Gene or Genome)" + }, + { + "input": "Definition: Urine cytology abnormal described as the presence in the urine of desquamated tubular epithelial cells or macrophages filled with lipid droplets.\nConcepts: SFRS2A (SRSF2 gene)\tMAURITANIA (Africa, Western)\tFat globules in urine (Urinary casts present)\tTITRIMETRIC PHENOL RED, CARBON-DIOXIDE (Indicator, Reagent, or Diagnostic Aid)\tIDH1(R132) inhibitor IDH305 (IDH1 inhibitor)", + "output": "Fat globules in urine (Urinary casts present)" + }, + { + "input": "Definition: Thyroid Neoplasm described as two types are found, familial and sporadic; if familial, the carcinoma is bilateral and may be associated with other benign or malignant endocrine organ tumors; if sporadic, it is unilateral; thyroidectomy and radiation therapy are treatments of choice.\nConcepts: Nisoldipinum (Calcium Channel Blocking Agents, Dihydropyridines)\tReference Result Value Type Code (Intellectual Product)\tPost-Transplant Lymphoproliferative Neoplasm (Lymphoid neoplasm)\tMature Plasma Cell to Lymphocyte Ratio Measurement (Laboratory Procedure)\tmedullary thyroid carcinoma (Primary malignant neoplasm of trunk)", + "output": "medullary thyroid carcinoma (Primary malignant neoplasm of trunk)" + }, + { + "input": "Definition: BEBQ Concurrent Version Questionnaire Question described as baby Eating Behaviour Questionnaire Concurrent Version (BEBQ Concurrent Version) My baby can easily take a feed within 30 minutes of the last one.\nConcepts: dTDP formation (Molecular Function)\tReceptor Agonist (Mixed Agonist/Antagonist)\tBEBQ Concurrent Version - Take a Feed Within 30 Minutes (BEBQ Concurrent Version Questionnaire Question)\tPositions, Seated (Changing basic body position)\tFollicular Lymphoma International Prognostic Index Score 2 (Follicular Lymphoma International Prognostic Index)", + "output": "BEBQ Concurrent Version - Take a Feed Within 30 Minutes (BEBQ Concurrent Version Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify gene variants associated with neurodegenerative disorders, a collection of diseases associated with progressive loss of neuronal structure and/or function. Genetic variants at multiple loci have been associated with neurodegenerative disorders. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple neurodegenerative disorder-associated loci simultaneously.\nConcepts: Subject Pool (Groups)\tregulation of chemokine secretion (Cell Function)\tDiabetic Kidney Disease Therapeutic Area User Guide v1.0 (Intellectual Product)\tAbnormal EMG, thenar or other hand muscles (Diagnostic tests)\tIVD Panels, Human Genetics, Neurodegenerative Disorder (Medical Device)", + "output": "IVD Panels, Human Genetics, Neurodegenerative Disorder (Medical Device)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - Since returning: I share many common interests and activities with family members.\nConcepts: DRRI-2 - P: Share Interests With Family (DRRI-2 Questionnaire Question)\tCHART-SF Paper Version - Medical Care Expense Last Year (Intellectual Product)\tDiamorphine (Phytochemicals)\tsaphenous nerve (Peripheral nerve of limb)\tBEBQ Retrospective Version - Baby Seemed Contented Feeding (Intellectual Product)", + "output": "DRRI-2 - P: Share Interests With Family (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of TORC2 signaling.\nConcepts: Leucine Zipper-Like Transcriptional Regulator 1 (TRANSCRIPTION FACTOR)\tTSCYC182 (Intellectual Product)\tregulation of TORC2 signaling (regulation of TOR signaling)\tHand Drills (Medical Device)\tTesticular Cancer Serum Markers Test Result SX (Testicular Cancer Serum Markers Test Result)", + "output": "regulation of TORC2 signaling (regulation of TOR signaling)" + }, + { + "input": "Definition: Breast Carcinoma described as cancer that has spread from where it started in the breast into surrounding, healthy tissue. Most invasive breast cancers start in the ducts (tubes that carry milk from the lobules to the nipple). Invasive breast cancer can spread to other parts of the body through the blood and lymph systems.\nConcepts: Lung Basaloid Large Cell Carcinoma (Basaloid carcinoma)\tLab. test result normal (Normal laboratory finding)\tInvasive Breast Carcinoma (Neoplastic Process)\tprimrose family (Wild flowers)\tHigh ornithine levels in cerebrospinal fluid (Finding)", + "output": "Invasive Breast Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Organism Function described as competitive interactions within multicellular organisms between cell populations that differ in growth rates, leading to the elimination of the slowest-growing cells.\nConcepts: Visual Analogue Lack of Appetite Scale (Intellectual Product)\tOils, Plant (PLANT, ALGAL AND FUNGAL PRODUCTS AND POISONS)\tHLA-DRA1 (Gene or Genome)\tcell competition in a multicellular organism (Organism Function)\tPuringergic Receptor P2Y, G-Protein Coupled, 2 (Receptors, Purinergic P2Y)", + "output": "cell competition in a multicellular organism (Organism Function)" + }, + { + "input": "Definition: something described as an inbred strain of athymic, nude mouse developed by transferring the Foxn1nu gene to a CD1 mouse.\nConcepts: CD1 NU (Mammal)\tHSPH1 protein, human (Molecular Chaperones)\tregulation of gene silencing by miRNA, negative regulation of translation (Genetic Function)\tUGT1-01 (Amino Acid, Peptide, or Protein)\tObject (Conceptual Entity)", + "output": "CD1 NU (Mammal)" + }, + { + "input": "Definition: pattern specification involved in kidney development described as any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate.\nConcepts: Asterias (Asteriidae)\tpolygonum hydropiper/smartwe (Plant)\tEGFR c.2239 2247del9 (Cell or Molecular Dysfunction)\tpattern specification involved in pronephros development (pattern specification involved in kidney development)\tHAEMOPHILUS PARAINFLUENZAE, BETA-LACTAMASE POSITIVE (Haemophilus parainfluenzae)", + "output": "pattern specification involved in pronephros development (pattern specification involved in kidney development)" + }, + { + "input": "Definition: something described as this gene plays a role in cysteine proteinase inhibition in saliva and other tissues.\nConcepts: Coagulation Analyzers, Automated (Blood coagulation analyzer)\tPapillary adenocarcinoma gastric (Sporadic Gastric Adenocarcinoma)\tUPD1-Weight (Intellectual Product)\tUterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pT0 TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Primary Tumor TNM Finding v8)\tCST1 (Gene or Genome)", + "output": "CST1 (Gene or Genome)" + }, + { + "input": "Definition: Functional Concept described as pertaining to the muscles and skeleton.\nConcepts: Urine potassium (Urine Chemistry Measurement)\tAPOBEC1-BINDING PROTEIN 1 (Gene or Genome)\trefsums disease (Disease or Syndrome)\tarterial calcification (Vascular calcification)\tMUSCULOSKELETAL (International Classification of Primary Care)", + "output": "MUSCULOSKELETAL (International Classification of Primary Care)" + }, + { + "input": "Definition: Classification described as a clinical staging system for neuroblastoma based on preoperative imaging and determined prior to any treatment, including surgery. It includes two stages of localized disease (L1 and L2) and two stages of metastatic disease (M and MS).\nConcepts: INRGSS (Classification)\tChloro-3 (N-methylpiperazinyl-3 propyl)-10 phenothiazine (Antipsychotic Agents)\tHeating Units, Laparoscopic Insufflation Gas (Medical Device)\tGlycogen Phosphorylase, Brain Form (Glycogen Phosphorylase)\texhalation (Respiratory cycle point)", + "output": "INRGSS (Classification)" + }, + { + "input": "Definition: Poisoning, Toxicology, Environmental Health described as injury to the body or interference of normal body functions by a substance that is swallowed, inhaled, injected, or absorbed.\nConcepts: {NOS} (General Qualifier)\tVulvar Superficial Angiomyxoma (Neoplastic Process)\tbacterial flagellum assembly (bacterial-type flagellum organization)\tmilliliter/square cm (Unit of Dose Calculation)\tPoisoning NOS (Poisoning / injury)", + "output": "Poisoning NOS (Poisoning / injury)" + }, + { + "input": "Definition: Testicular and epididymal neoplasms described as stage II includes: Any pT/TX, N1-3, M0, SX. pTX: Primary tumor cannot be assessed. N1: Metastasis with a lymph node mass 2 cm or less in greatest dimension; or multiple lymph nodes, none more than 2cm in greatest dimension. N2: Metastasis with a lymph node mass more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, any one mass greater than 2 cm but not more than 5 cm in greatest dimension. N3: Metastasis with a lymph node mass more than 5 cm in greatest dimension. M0: No distant metastasis. SX: Marker studies not available or not performed.\nConcepts: X-ray system generator (Generators)\tTrichoodontoonychial dysplasia (Congenital anomaly of nail)\tStage II Testicular Mixed Germ Cell Tumor (Neoplastic Process)\tMyeloid Neoplasm Finding (Finding)\tRenal Pelvis and Ureter Urothelial Carcinoma pT3 TNM Finding v8 (Renal Pelvis and Ureter Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "Stage II Testicular Mixed Germ Cell Tumor (Neoplastic Process)" + }, + { + "input": "Definition: enzyme structure described as molecular location on an enzyme where substrate binds and catalysis occurs.\nConcepts: Were Additional Molecular Studies Performed (Intellectual Product)\tPressure, Subarachnoid (Central nervous system pressure)\tC-SSRS Baseline - Number of Actual Suicide Attempts (Intellectual Product)\tActive Sites (Functional Concept)\tHEALTH SERV WOMANS (health service or program by target group)", + "output": "Active Sites (Functional Concept)" + }, + { + "input": "Definition: Flower Essences described as california blackberry.\nConcepts: Psychological Dependency (Personality Traits)\tUsually Have Considerable Trouble Concentrating (Intellectual Product)\tRubus ursinus / California blackberry (Pharmacologic Substance)\tStage IIA Small Cell Carcinoma of the Lung (Neoplastic Process)\tSynapse structure (intercellular connection)", + "output": "Rubus ursinus / California blackberry (Pharmacologic Substance)" + }, + { + "input": "Definition: Voice described as disorders of speech articulation caused by imperfect coordination of pharynx, larynx, tongue, or face muscles. This may result from CRANIAL NERVE DISEASES; NEUROMUSCULAR DISEASES; CEREBELLAR DISEASES; BASAL GANGLIA DISEASES; BRAIN STEM diseases; or diseases of the corticobulbar tracts (see PYRAMIDAL TRACTS). The cortical language centers are intact in this condition.\nConcepts: Asymmetry of intraocular pressure (Abnormal intraocular pressure)\tDysarthrias (Speech & Language Disorders)\tWaardenburg syndrome type 2 with ocular albinism (Disease or Syndrome)\tpositive regulation of alkaline phosphatase activity (Molecular Function)\tAbsence of GnRH pulsatility (Finding)", + "output": "Dysarthrias (Speech & Language Disorders)" + }, + { + "input": "Definition: something described as a composite structure of the midbrain tegmentum that includes the ventral tegmental area, the interpeduncular nucleus and the peripeduncular nucleus ( Crosby-1962 ).\nConcepts: body vertebral (Subdivision of vertebra)\tComplete Atrioventricular Canal Defect (Atrioventricular Septal Defect)\tH-37 (Gene or Genome)\tComprehensive Hereditary Periodic Fever Syndrome Gene Panel Reagents (IVD Panels, Human Genetics, Periodic Fever Syndrome)\tbasal tegmental gray (Tissue)", + "output": "basal tegmental gray (Tissue)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Actinobacillus ligniersii.\nConcepts: Tafil (Organic Chemical)\tregulation of synapse structural plasticity (regulation of synapse organization)\tEFFRGOA (Finding)\tActinobacillus lignieresi (Actinobacillus)\tFe (Iron Compounds, Unspecified)", + "output": "Actinobacillus lignieresi (Actinobacillus)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of Fusarium proliferatum IgE antibody present in a sample.\nConcepts: I am sleeping well (Intellectual Product)\tFusarium proliferatum IgE Antibody Measurement (Laboratory Procedure)\tGrade 4 Neonatal Pulmonary Hemorrhage, AE (Neonatal Pulmonary Hemorrhage, Adverse Event)\tDNA-3'pp5'G guanylate hydrolase (Molecular Function)\tcellular response to retinol (response to vitamin A)", + "output": "Fusarium proliferatum IgE Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Cluster of differentiation antigen 56-78 described as an integrin beta subunit of approximately 85-kDa in size which has been found in INTEGRIN ALPHAIIB-containing and INTEGRIN ALPHAV-containing heterodimers. Integrin beta3 occurs as three alternatively spliced isoforms, designated beta3A-C.\nConcepts: beta3 Integrin (Clusters of differentiation)\tOXIMETER TO MEASURE HEMOGLOBIN (Medical Device)\tThalamic Nuclei (diencephalon nuclei)\tbotulinum toxinum/botulinum (Pharmacologic Substance)\tprint (Copying Processes)", + "output": "beta3 Integrin (Clusters of differentiation)" + }, + { + "input": "Definition: Clinical Class described as having to do with the heart and lungs.\nConcepts: Biological Maternal Cousin (Family Group)\tVasodilator Agents (Agent Affecting Cardiovascular System)\tcAMP Responsive Element Binding Protein 3-Like 2 wt Allele (CREB3L2 gene)\tabieta-7,13-diene hydroxylase activity (Molecular Function)\theart and lung (Heart)", + "output": "heart and lung (Heart)" + }, + { + "input": "Definition: Drug stick described as solid single-dose preparation of usually conical shape intended to be inserted in the external auditory meatus where it melts or dissolves.\nConcepts: Recreation (Daily or Recreational Activity)\tGrade 1 Dry mouth (Finding)\tspermidine biosynthesis (spermidine metabolic process)\tresponse to riboflavin (response to vitamin)\tEar stick (Drug stick)", + "output": "Ear stick (Drug stick)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a group of membrane transport proteins that transport biogenic amine derivatives of catechol across the PLASMA MEMBRANE. Catecholamine plasma membrane transporter proteins regulate neural transmission as well as catecholamine metabolism and recycling.\nConcepts: Reimplantation - action (Surgical Replantation)\tPERCUTANEOUS CORONARY INTERVENTION (PCI) FOR ST ELEVATION MYOCARDIAL INFARCTION (STEMI) (Cardiovascular Surgical Procedures)\tAsiminas (Annoneae)\tCatecholamine Transport Protein (Amino Acid, Peptide, or Protein)\tMyocardial Infarction, CTCAE (Finding)", + "output": "Catecholamine Transport Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as congenital absence or underdevelopment of the fovea centralis.\nConcepts: Aplasia/Hypoplasia of the fovea (Aplasia/Hypoplasia of the macula)\tFLJ20756 (Gene or Genome)\tclomipramine HCl (Pharmacologic Substance)\tmuscle thin filament tropomyosin (protein-containing complex)\tCarbon C 14 Eribulin Acetate (Radioconjugate)", + "output": "Aplasia/Hypoplasia of the fovea (Aplasia/Hypoplasia of the macula)" + }, + { + "input": "Definition: something described as a rare chromosomal anomaly syndrome resulting from the partial duplication of the short arm of chromosome 16. The disorder has a highly variable phenotype with typical characteristics of developmental/psychomotor delay (particularly of speech), intellectual disability, autism spectrum disorder, dysmorphic facial features (triangular face, deep set eyes, broad and prominent nasal bridge, up slanting or narrow palpebral features, hypertelorism). Additionally, finger/hand anomalies, short stature, microcephaly and slender build are frequently described.\nConcepts: Breast implant sizer (Breast Prosthesis, Internal)\tTrisomy 16p11.2p12.2 (16p partial trisomy syndrome)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Light Chain, Lambda (Medical Device)\tPagers (Device associated with paging systems)\tI felt worthless (Intellectual Product)", + "output": "Trisomy 16p11.2p12.2 (16p partial trisomy syndrome)" + }, + { + "input": "Definition: Accessory ligament of shoulder joint described as a supporting structure of the shoulder consisting of the muscles and tendons that attach the arm to the shoulder joint and enable the arm to move.\nConcepts: Q-LES-Q - Decisive With Regard to Household Activities (Intellectual Product)\tcamphor 5-exohydroxylase activity (Molecular Function)\tpositive regulation of cell communication by chemical coupling (Cell Function)\tCoronary vasodilator (Vasodilator Agents)\tRotator cuff including muscles and tendons (Tendon structure)", + "output": "Rotator cuff including muscles and tendons (Tendon structure)" + }, + { + "input": "Definition: Adult human body described as bodily system consisting of the heart, blood vessels, and blood that circulates blood throughout the body, delivers nutrients and other essential materials to cells, and removes waste products.\nConcepts: Rolitetraciclina (Organic Chemical)\tMACROTHROMBOCYTOPENIA AND GRANULOCYTE INCLUSIONS WITH OR WITHOUT NEPHRITIS OR SENSORINEURAL HEARING LOSS (Hereditary white blood cell disorder)\tprotein-lysine lysylation (peptidyl-lysine modification)\tTRAY, CATHETERIZATION, STERILE URETHRAL, WITH OR WITHOUT CATHETER (Medical Device)\tCV system (German translation of the Medical Subject Headings)", + "output": "CV system (German translation of the Medical Subject Headings)" + }, + { + "input": "Definition: something described as the percentage of the administered dose that is recovered from the specimen type specified in PPSPEC, between doses (TAU).\nConcepts: paracolic gutter (Structure of paracolic region)\tPct Rec Over Dosing Interval (Quantitative Concept)\tMicroscopes, Light, Laboratory, Polarized Light (Medical Device)\tM7-Acute megakaryoblas leukaem (Leukemia, Myelocytic, Acute)\tHead Law (Idea or Concept)", + "output": "Pct Rec Over Dosing Interval (Quantitative Concept)" + }, + { + "input": "Definition: VLERS Clinical Classification Question described as vignos Lower Extremity Rating Scale - Vignos rating scale.\nConcepts: Lateral hypothalamic nucleus (Hypothalamic nucleus)\tSarcoma of the Orbit pM1 TNM Finding v7 (Finding)\tVLERS101 (Intellectual Product)\tPERICARDIAL CONSTRICTION (Abnormal pericardium morphology)\tBaseline Removal Method (Research Activity)", + "output": "VLERS101 (Intellectual Product)" + }, + { + "input": "Definition: Coagulation and bleeding analyses described as a measurement of the total protein S in a biological specimen.\nConcepts: GLUT-2 protein, human (Amino Acid, Peptide, or Protein)\tGAIA Level 1 Neonatal Death in a Term Live Birth (Intellectual Product)\tPROTS (anticoagulant assays)\ttyramine-beta hydroxylase activity (Molecular Function)\tTenosuspension (Operation on tendon)", + "output": "PROTS (anticoagulant assays)" + }, + { + "input": "Definition: something described as a molecular genetic abnormality indicating the presence of a mutation in exon 19 of the EGFR gene.\nConcepts: EGFR DEL19 (EGFR gene mutation)\tComputers (Computer equipment)\tCSS06-Most Recent Attempt Date (C-SSRS Children's Baseline Questionnaire Question)\tNeuropathy, Pudendal (Pudendal nerve neuropathy)\tenzyme active site formation via L-cysteine sulfinic acid (Molecular Function)", + "output": "EGFR DEL19 (EGFR gene mutation)" + }, + { + "input": "Definition: something described as any of more than a dozen Tai languages spoken by the Zhuang people of southern China in the province of Guangxi and adjacent parts of Yunnan and Guangdong.\nConcepts: Proboscis lateralis (Congenital anomaly of face)\tdata model (Intellectual Product)\tChuang (Tai language)\tAdducted thumbs, arthrogryposis syndrome, Dundar type (Distal arthrogryposis syndrome)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Pseudomonas aeruginosa (Medical Device)", + "output": "Chuang (Tai language)" + }, + { + "input": "Definition: something described as lysosomal storage disease due to defective alpha-mannosidase with resultant oligosaccharide accumulation.\nConcepts: Ancestry Informative Marker (Functional Concept)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 1 Neonatal Infectious Meningitis (Intellectual Product)\tNeuropharmacologies (Biomedical Occupation or Discipline)\tLaser Drill Formulation Process (Drug Formulation Process)\tMannosidosis, NOS (Carbohydrate Metabolism, Inborn Errors)", + "output": "Mannosidosis, NOS (Carbohydrate Metabolism, Inborn Errors)" + }, + { + "input": "Definition: something described as this gene plays a role in signal transduction and is involved in neurotransmission.\nConcepts: LONG BONE FRACTURE (Fractures, Multiple)\tMutY-Like Protein Variant (Cell or Molecular Dysfunction)\tARR1 (Signaling Pathway Gene)\tedema; larynx (Abnormal larynx morphology)\tMETHYLENE BLUE THIOCYANATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "ARR1 (Signaling Pathway Gene)" + }, + { + "input": "Definition: something described as alterations or deviations from normal shape or size which result in a disfigurement of the hand.\nConcepts: Dietary Service (Health Services)\tdeformities hand (Deformity)\tHenipavirus (Orthoparamyxovirinae)\tAutologous GVAX Lung Cancer Vaccine (Pharmacologic Substance)\tsign lang intrp 15min (Health Care Activity)", + "output": "deformities hand (Deformity)" + }, + { + "input": "Definition: something described as the device does not have a fail-safe mechanism, although such mechanism would be required for its appropriate and/or safe functioning.\nConcepts: sucrose:1,6(1,3)-alpha-D-glucan 6(3)-alpha-D-glucosyltransferase activity (glucosyltransferase activity)\tNo Fail-Safe Mechanism (Finding)\tDevelopment, Maxillofacial (Organism Function)\tBN2 Diffuse Large B-Cell Lymphoma (Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Molecular Subtypes)\tHyperparathyroidisms, Primary (Hyperparathyroidism)", + "output": "No Fail-Safe Mechanism (Finding)" + }, + { + "input": "Definition: Finding described as increased amount of myelin in the central nervous system.\nConcepts: negative regulation by host of viral release from host cell (Biologic Function)\tMastoid process of temporal bone (middle ear)\tCNS hypermyelination (Abnormal CNS myelination)\tSurgical Scissors (Scissors)\tSOLUTION, NEWCOMER'S (Indicator, Reagent, or Diagnostic Aid)", + "output": "CNS hypermyelination (Abnormal CNS myelination)" + }, + { + "input": "Definition: Immunologic Factor described as an ointment formulation composed of a purified sheep immunoglobulin G (IgG) antibody against the non-functional form of the purinergic P2X7 receptor (nf-P2X7), with potential antineoplastic activity. Upon topical application of the anti-nf-P2X7 antibody ointment BIL-010t, the antibody binds to nf-P2X7 and inhibits its antiapoptotic activity. This may induce apoptosis and inhibit the growth of nf-P2X7-overexpressing cancer cells. P2X7, an ATP-gated cation-selective channel, plays a role in the induction of apoptosis; nf-P2X7, is upregulated in a variety of cancer cell types while not expressed on normal, healthy cells and is unable to form a large transmembrane, apoptotic pore upon exposure to ATP and prevents apoptosis.\nConcepts: Manufacture, Recombinant Protein (Manufacture)\tI am bothered by feelings or thoughts about changes to my body (Clinical or Research Assessment Question)\tEsophagus Complete GvHD Response (Complete Response in GvHD)\tstaphylococcus albus (Genus staphylococcus)\tAnti-nf-P2X7 Antibody Ointment BIL-010t (Pharmacologic Substance)", + "output": "Anti-nf-P2X7 Antibody Ointment BIL-010t (Pharmacologic Substance)" + }, + { + "input": "Definition: Qualitative Concept described as an event or action that occurs successively after another.\nConcepts: Bulbomembranous Urethra (Urethra part)\tVS (Organic Chemical)\tTubulin Tyrosine Ligase (Amino Acid, Peptide, or Protein)\tSequential (Temporal Qualifier)\thnpcc (Primary malignant neoplasm of colon)", + "output": "Sequential (Temporal Qualifier)" + }, + { + "input": "Definition: something described as a conjugate vaccine of meningococcal polysaccharide used for active immunization against invasive meningococcal disease caused by Neisseria meningiditis serogroups A, C, Y, and W-135.\nConcepts: Meningococcal Conjugate Vaccine MCV4 (Pharmacologic Substance)\tAbnormality of the premaxilla (Anatomical Abnormality)\tOcular Adnexal Lymphoma pT2d TNM Finding v7 (Ocular Adnexal Lymphoma pT2 TNM Finding v7)\tCDISC Virology Therapeutic Area User Guide Version 2.1 (Intellectual Product)\tdown regulation of glycolysis (negative regulation of catabolic process)", + "output": "Meningococcal Conjugate Vaccine MCV4 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a member of the Phasianidae family of pheasants that includes several genera, including Cotumix, Anurophasis, Perdicula and Ophrysia.\nConcepts: Wide metaphyses (Radiologic finding)\tquail (Family Phasianidae)\tOversight Committee Type Code (Type Code)\tCOMPREHENSIVE DENT CARE (Health Care Activity)\tAddress (Document type)", + "output": "quail (Family Phasianidae)" + }, + { + "input": "Definition: something described as binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.\nConcepts: Irregular septal thickening on pulmonary HRCT (Finding)\tC3-INDIRECT IMMUNOFLUORESCENT SOLID PHASE (Medical Device)\tcellular nitrogen compound catabolic process (cellular catabolic process)\tprotein kinase activator activity (kinase activator activity)\tMaintenance Clinical Trial Setting (treatment setting)", + "output": "protein kinase activator activity (kinase activator activity)" + }, + { + "input": "Definition: something described as the means used to coordinate the collection or reconstruction of data with the cardiac cycle. EXAMPLE(S): NONE, REALTIME, PROSPECTIVE, RETROSPECTIVE, PACED OTHER NAME(S): Cardiac Synchronization Technique (0018,9037) NOTE(S):\nConcepts: ROCK0101 (Intellectual Product)\tImagingAcquisitionProtocolElement.cardiacSynchronizationTechniqueCode (Intellectual Product)\tJELLY, CONTACT, FOR TRANSURETHRAL SURGICAL INSTRUMENT (Medical Device)\tPatient compliance (Social Behavior)\tOvarian theca cell tumour (Neoplastic Process)", + "output": "ImagingAcquisitionProtocolElement.cardiacSynchronizationTechniqueCode (Intellectual Product)" + }, + { + "input": "Definition: something described as a form of a chemical element containing a specific number of neutrons and a specific atomic mass.\nConcepts: Bislama language (Language)\tisotope (Inorganic Chemicals)\tAnalyte (Substance categorized functionally)\tIris Melanoma pT1c TNM Finding v8 (Finding)\tGARS (Gene or Genome)", + "output": "isotope (Inorganic Chemicals)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week, how often have you: taken care of work by yourself when it was necessary?\nConcepts: United States. Dept. of Veterans Affairs (Professional Organization or Group)\tQ-LES-Q - Taken Care of Work by Yourself (Q-LES-Q Questionnaire Question)\tDiffused (Natural Phenomenon or Process)\tMCT 1 (Amino Acid, Peptide, or Protein)\tRIBONUCLEASE 4 (Gene or Genome)", + "output": "Q-LES-Q - Taken Care of Work by Yourself (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: Finding described as moderate; minimal, local or noninvasive intervention indicated; limiting age-appropriate instrumental ADL\nConcepts: Grade 2 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE (Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE)\tDifferentiation Factor, Eosinophil (I [Preparations])\tSt.JnMethNromsclrTherp ea.15 (Therapeutic or Preventive Procedure)\tMicrovascular Bed (Body Part, Organ, or Organ Component)\tNon-Specific Cross-Reacting Antigen NCA-95 (Immunologic Factor)", + "output": "Grade 2 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE (Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE)" + }, + { + "input": "Definition: Clinical Observation described as closely watching a patient's condition but not giving treatment unless there are changes in test results. Active surveillance avoids problems that may be caused by treatments such as radiation or surgery. It is used to find early signs that the condition is getting worse. During active surveillance, patients will be given certain exams and tests done on a regular schedule. It is sometimes used in prostate cancer.\nConcepts: Group 1 (Clinical or Research Assessment Answer)\tIOS (Diagnostic Procedure)\tImmature Retinal Vasculature in Retinal Anatomic Zone 3 (Immature Retinal Vasculature)\tobservation (Health Care)\tMucopolysaccharidosis NOS (Mucinoses)", + "output": "observation (Health Care)" + }, + { + "input": "Definition: Quantitative Concept described as measurements or calculations on measurements obtained from electrocardiographic tracings.\nConcepts: BEBQ0205 (BEBQ Retrospective Version Questionnaire Question)\tneuraminate aldolase activity (Molecular Function)\tCPNIGAAB (Laboratory Procedure)\tEKG Measurement (Measurement)\tStage IIIC1 Cervical Cancer FIGO 2018 (Stage IIIC Cervical Cancer FIGO 2018)", + "output": "EKG Measurement (Measurement)" + }, + { + "input": "Definition: Serial Position Effect described as component of the serial position effect which is manifested by a greater ease in learning items that occur at the beginning of a series rather than those toward the middle. Compare RECENCY EFFECT.\nConcepts: CHN (Gene or Genome)\tChristian Science support in-office 80 minutes (Christian Science care)\tPrimacy Effect (Serial Position Effect)\tOXACILLIN RESISTANT STAPHYLOCOCCUS AUREUS (Bacterium)\tClinical History (Intellectual Product)", + "output": "Primacy Effect (Serial Position Effect)" + }, + { + "input": "Definition: Conceptual Entity described as an indication as to whether the data submitted to EudraCT should be saved to EudraCT as an XML file.\nConcepts: PTCH Gene Deletion (Cell or Molecular Dysfunction)\tb-primeverosidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)\tregulation of response to external stimulus (regulation of response to stimulus)\tDKK4 Gene (Signaling Pathway Gene)\tStudy Saved as XML Indicator (Indicator)", + "output": "Study Saved as XML Indicator (Indicator)" + }, + { + "input": "Definition: protein-containing complex described as protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).\nConcepts: Parecoxib (Organic Chemical)\tapolipoprotein B mRNA editing enzyme complex (protein-containing complex)\tbehavioral/social science (CRISP Thesaurus)\t7-(alpha-(2-aminomethylphenyl)acetamido)-3-((1-carboxymethyltetrazol-5-ylthio)methyl)-3-cephem-4-carboxylic acid (Cephalosporins)\tAreas, Preoptic (Hypothalamus, Anterior)", + "output": "apolipoprotein B mRNA editing enzyme complex (protein-containing complex)" + }, + { + "input": "Definition: C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version Phase 1 Study 1/14/09 (C-SSRS Baseline/Screening Version Phase 1 Study 1/14/09) Have you been thinking about how you might do this? (Past 6 Months).\nConcepts: rituximab-etoposide-prednisone-Oncovin-cyclophosphamide-hydroxydaunorubicin regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)\testablishment of endothelial barrier (endothelial cell development)\tC-SSRS Baseline/Screening Version Phase 1 Study - Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tCancer Antigen 19-9 (Tumor antigen measurement)\tNeurotrophic Tyrosine Kinase Receptor Type 1 Protein Variant (Gene Product Sequence Variation)", + "output": "C-SSRS Baseline/Screening Version Phase 1 Study - Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)" + }, + { + "input": "Definition: Cell Component described as a multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.\nConcepts: Grade 2 Cushingoid, CTCAE (Cushingoid, CTCAE)\tTCR signalosome (Cell Component)\tRehearsing (Mental Process)\ttermination of monopolar cell growth (negative regulation of monopolar cell growth)\tRod-cone dystrophy (Retinal Dystrophies)", + "output": "TCR signalosome (Cell Component)" + }, + { + "input": "Definition: Genetic Engineering described as methods for controlling genetic SEX of offspring.\nConcepts: Leasings, Property (Occupational Activity)\tpositive regulation of chylomicron remodeling (Cell Function)\tPredetermination, Sex (Genetic Engineering)\tEpileptic Encephalopathy, Early Infantile, 3 (Myoclonic disorder)\texo-1,6-alpha-glucosidase activity (glucosidase activity)", + "output": "Predetermination, Sex (Genetic Engineering)" + }, + { + "input": "Definition: something described as human CDKN2B wild-type allele is located within 9p21 and is approximately 27 kb in length. This allele, which encodes cyclin-dependent kinase 4 inhibitor B protein, plays roles in both the regulation of cell growth and tumor suppression.\nConcepts: Drug Manufacturer (Manufacturer Name)\tDISORDER EAR (Disorder of head)\tubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate (Molecular Function)\tTP15 (CDKN2B gene)\tPeripheral T-cell Lymphoma Prognostic Index Score 1 (Finding)", + "output": "TP15 (CDKN2B gene)" + }, + { + "input": "Definition: something described as the parts of the spinal cord that give rise to nerves entering and leaving the spinal canal at the levels of the lumbar vertebrae. These segments have massive anterior gray column and posterior gray column and are nearly circular in horizontal sections ( Carpenter-1983 ). Defined by dissection, they are found in all vertebrates ( Swanson-2015 ).\nConcepts: CDK1/2/4 Inhibitor AG-024322 (Pharmacologic Substance)\tSynovial Capsule (Soft tissue joint component)\tSegmenta lumbalia (Spinal Cord)\tChromaticity (Thesaurus of Psychological Index Terms)\tLUMBAR SPINE (Vertebral column)", + "output": "Segmenta lumbalia (Spinal Cord)" + }, + { + "input": "Definition: Pharmacologic Substance described as brand name of an antipsychotic drug\nConcepts: gemini hypothalamic nucleus (Body Part, Organ, or Organ Component)\torap (Pharmacologic Substance)\tHelicobacter pylori-associated gastritis (Bacterial gastrointestinal infectious disease)\tRat Transgene (Research Activity)\tGroll-Hirschowitz Syndrome (Sensory neuropathy)", + "output": "orap (Pharmacologic Substance)" + }, + { + "input": "Definition: Quantitative Concept described as the maximum volume of air a subject can inhale into the lungs after a tidal exhalation (IRV plus TV) as a proportion of the predicted normal value.\nConcepts: ICPP (Quantitative Concept)\tProstate Ductal Adenocarcinoma, Papillary Pattern (Infiltrating papillary adenocarcinoma)\tPerformed Procedure Target Anatomic Site Code (Intellectual Product)\tSurvivin Antigen Vaccine DPX-Survivac (Vaccines, Peptide)\tPrimary Fibrosarcoma (Non-Metastatic Neoplasm)", + "output": "ICPP (Quantitative Concept)" + }, + { + "input": "Definition: something described as an acute myeloid leukemia with mutation of the nucleophosmin gene. It is usually associated with normal karyotype and frequently has myelomonocytic or monocytic features. It usually responds to induction therapy.\nConcepts: Fusion of the left and right thalami (Finding)\ttermination of T cell signal transduction (termination of signal transduction)\tCavernous haemangioma of retina (Benign neoplasm of blood vessel of head)\tpostcentral gyrus (Entire parietal lobe gyrus)\tAML with Mutated NPM1 (Neoplastic Process)", + "output": "AML with Mutated NPM1 (Neoplastic Process)" + }, + { + "input": "Definition: something described as catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH.\nConcepts: Chromatin Assembly Factor I (Amino Acid, Peptide, or Protein)\tIRIS PALLIDA ROOT OIL (Organic Chemical)\tBromate (Inorganic Chemical)\tIPA01-Days Vigorous Physical Activities (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tNADP-1,2-propanediol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "NADP-1,2-propanediol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of topical bexarotene that may be used in the treatment of primary cutaneous lymphomas.\nConcepts: Organodithiophosphonates (Organic Chemical)\tBexarotene Topical Regimen (Therapeutic or Preventive Procedure)\tHPLC/IEX (Laboratory Procedure)\tKidney Neuroendocrine Neoplasm (Neoplastic Process)\tExperimental Psychology, Animal (Occupation or Discipline)", + "output": "Bexarotene Topical Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as any process involved in forming the mature 3' end of a snoRNA molecule linked to prior polyadenylation of the 3'-end of the precursor snoRNA.\nConcepts: endomembrane system (cellular anatomical entity)\tpolyadenylation-dependent snoRNA 3'-end processing (Genetic Function)\tIrregular epiphysis of the distal phalanx of the 3rd finger (Abnormality of the epiphysis of the distal phalanx of the 3rd finger)\tTABLESPOON (Potency Unit)\tprostate abnormal (Disorder of the genitourinary system)", + "output": "polyadenylation-dependent snoRNA 3'-end processing (Genetic Function)" + }, + { + "input": "Definition: something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Remembering test instructions.\nConcepts: aromatic (S)-hydroxynitrile lyase activity (aldehyde-lyase activity)\tCovered Stents (Stent, device)\tBahupatra (Plant)\tanterior laterolateral visual area (Visual Cortex - rodent)\tRemembering Test Instructions (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Remembering Test Instructions (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: branch elongation of an epithelium described as the process in which a bud in the lung grows out from the point where it is formed.\nConcepts: MHSTDTC (Observation Start Date Time)\tPrimary Peritoneal Transitional Cell Carcinoma (Neoplastic Process)\tSpinning Disk Confocal Microscopes (Microscopes)\tbud elongation involved in lung branching (branch elongation of an epithelium)\tLASSITUDE (Level of fatigue)", + "output": "bud elongation involved in lung branching (branch elongation of an epithelium)" + }, + { + "input": "Definition: something described as a central nervous system fluid shunt is a device or combination of devices used to divert fluid from the brain or other part of the central nervous system to an internal delivery site or an external receptacle for the purpose of relieving elevated intracranial pressure or fluid volume (e.g., due to hydrocephalus). Components of a central nervous system shunt include catheters, valved catheters, valves, connectors, and other accessory components intended to facilitate use of the shunt or evaluation of a patient with a shunt.\nConcepts: Planned Pharmacologic Target Entrez Gene Identifier (Unique Identifier)\tnon-adjuvanted A(H1N1) influenza vaccine (Viral Vaccines)\tdown regulation of patterning of blood vessels (Organ or Tissue Function)\tEXTERNAL ILIAC LYMPH NODE (Common iliac lymph node)\tSHUNT, CENTRAL NERVOUS SYSTEM AND COMPONENTS (Medical Device)", + "output": "SHUNT, CENTRAL NERVOUS SYSTEM AND COMPONENTS (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as health Assessment Questionnaire Disability Index With Pain Visual Analog Scale - Usually need help from another person: Dressing and grooming.\nConcepts: Rooming (Health Care Activity)\tDrug Withdrawn (Therapeutic or Preventive Procedure)\tHAQ0119 (Intellectual Product)\tPharmacogenomics (Laboratory Class)\tMetilcelulosa (Polysaccharides)", + "output": "HAQ0119 (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human CFP wild-type allele is located in the vicinity of Xp11.4 and is approximately 6 kb in length. This allele, which encodes properdin protein, is involved in the positive regulation of the alternative complement pathway. Point mutations in the gene are associated with properdin deficiency.\nConcepts: CFP wt Allele (CFP gene)\tmonomethylamine (Amines)\tPyrazinamide (Pyrazines)\tUnknown if Has Sibling (Finding)\tPhospholipase C delta (Enzyme)", + "output": "CFP wt Allele (CFP gene)" + }, + { + "input": "Definition: something described as pleural mesothelioma with a tumor limited to the ipsilateral parietal pleura with or without mediastinal pleura and with or without diaphragmatic pleural involvement.\nConcepts: Spondyloarthropathy (Disease or Syndrome)\tblood flow velocity (Hemorheology)\tFemale genital mutilation type 2 (Acquired Abnormality)\tCity (Geographic Locations)\tPleural Mesothelioma pT1 TNM Finding v7 (Pleural Mesothelioma Pathologic Primary Tumor TNM Finding v7)", + "output": "Pleural Mesothelioma pT1 TNM Finding v7 (Pleural Mesothelioma Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Quantitative Concept described as preparation of a homeopathic substance with a ratio of one part original material to 10 parts of carrier or solvent, traditionally lactose, water or ethanol.\nConcepts: sulfur amino acid biosynthesis (sulfur compound biosynthetic process)\tAnencephalia (Microcephaly)\tCRQ-SAS First Administration Version - Felt Low in Energy (Intellectual Product)\tX (Homeopathic Dilution Unit)\tSubfacial (Spatial Concept)", + "output": "X (Homeopathic Dilution Unit)" + }, + { + "input": "Definition: something described as human MIR574 wild-type allele is located within chromosome 4 and is approximately 1 kb in length. This allele, which encodes MIR574 pre-miRNA, may be involved in the regulation of gene expression.\nConcepts: Sulfamezathine (Antibiotic)\tAcquired prothrombin deficiency (Coagulation factor deficiency syndrome)\tDevice Observer Serial Number (Identifier)\tMicro RNA 574 Gene (Gene or Genome)\tExtraocular muscle palsy (Abnormal ocular motility)", + "output": "Micro RNA 574 Gene (Gene or Genome)" + }, + { + "input": "Definition: Disease of mucous membrane described as gastritis characterized by hypertrophy of the gastric mucosa with creation of giant gastric folds. It is associated with hypoalbuminemia due to albumin loss from the stomach. Signs and symptoms include nausea, vomiting, abdominal pain, edema, and weight loss.\nConcepts: Polypoid swelling of gastric mucous membrane (Disorder of soft tissue of body cavity)\tStanford Aortic Dissection Classification (Classification)\torganic cyclic compound anabolism (organic cyclic compound metabolic process)\tFPI - date, time (Date/Time)\tregulation by virus of host immune system process (modulation by symbiont of host immune response)", + "output": "Polypoid swelling of gastric mucous membrane (Disorder of soft tissue of body cavity)" + }, + { + "input": "Definition: Disorders of the external female genitalia described as a clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004\nConcepts: Amblycera (Mallophaga)\tDifficult to Open or Close (Finding)\tDental Care (Dental Procedures)\tmovement disorder (Movement Disorders)\tGENITAL LEUKOPLAKIA (Disease or Syndrome)", + "output": "GENITAL LEUKOPLAKIA (Disease or Syndrome)" + }, + { + "input": "Definition: Congenital anomaly of brain described as a congenital syndromic form of split-hand/foot malformation with features of microcephaly, microphthalmia, ectrodactyly of the lower limbs and prognathism. Intellectual deficit has been reported. MMEP syndrome is considered to be a very rare condition. Disruption of the sorting nexin 3 gene (SNX3; 6q21) has been shown to play a causative role in MMEP.\nConcepts: Calcium-Dependent Neutral Protease (Enzyme)\t10: 62208242-62223930 (Spatial Concept)\tMMEP syndrome (Microcephaly)\tTPM4 (Amino Acid, Peptide, or Protein)\tmaintenance of transcriptional fidelity during DNA-dependent transcription elongation (RNA chemical synthesis)", + "output": "MMEP syndrome (Microcephaly)" + }, + { + "input": "Definition: Finding described as increased susceptibility to infection by the protozan parasite of the genus Leishmania.\nConcepts: negative regulation of very-low-density lipoprotein particle clearance (negative regulation of lipoprotein particle clearance)\tCubic Meter/Second (SI units of mass per unit time)\tRhynchelytrum repen (Poaceae)\tLEISHMANIASIS, TEGUMENTARY, SUSCEPTIBILITY TO (Recurrent protozoan infections)\tDRRI-2 - J: Leaders Interested in Welfare (DRRI-2 Questionnaire Question)", + "output": "LEISHMANIASIS, TEGUMENTARY, SUSCEPTIBILITY TO (Recurrent protozoan infections)" + }, + { + "input": "Definition: Molecular Function described as phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3). DG is necessary for further activation of Protein Kinase C while IP3 leads to the release of intracellular calcium.\nConcepts: Calbindin Measurement (Laboratory Procedure)\tCrithidias (Trypanosomatina)\tcallicarpa/zi zhu (Oriental herbs and natural substances letter C)\tNon-hematological malignant tumors (Classification)\tPhospholipase C Signaling Pathway (Molecular Function)", + "output": "Phospholipase C Signaling Pathway (Molecular Function)" + }, + { + "input": "Definition: Carbohydrates described as carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc.\nConcepts: Conventional release buccal film (Buccal dose form)\tCSS05-Most Lethal Attempt Damage (C-SSRS Already Enrolled Subjects Questionnaire Question)\tdietary carbohydrates (Carbohydrates)\tDERUNG (Population Group)\tNarcissism (Personality Traits)", + "output": "dietary carbohydrates (Carbohydrates)" + }, + { + "input": "Definition: Disease or Syndrome described as spontaneous flow of milk from the breast, unassociated with childbirth or nursing.\nConcepts: Unit/meter2 (Unit of Dose Calculation)\tGalactorrhoea due to non-obstetric cause (Female Reproductive System Disorder)\tmyelocyte (Cell)\tI have to limit my physical activity because of diarrhea (Clinical or Research Assessment Question)\tImmune thrombocytopenia (Disease or Syndrome)", + "output": "Galactorrhoea due to non-obstetric cause (Female Reproductive System Disorder)" + }, + { + "input": "Definition: something described as cholesterine.\nConcepts: Minor Salivary Gland Cancer (Malignant tumor of minor salivary gland)\tMedicinal Plant (Plant)\tCholesterinum / cholesterine (Pharmacologic Substance)\tV-sign (Erythema)\tBPI - Pain at its Least in Last Week (Intellectual Product)", + "output": "Cholesterinum / cholesterine (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was able none of the time.\nConcepts: Able none of the time (Finding)\tEXACT1-Describe How Breathless (EXACT Questionnaire Question)\tsingle strand conformation polymorphism (Chromosome Mapping)\tChildhood Lymphoma by AJCC v8 Stage (Lymphoma by AJCC v8 Stage)\tBiosynthesis of Spermidine and Spermine (Functional Concept)", + "output": "Able none of the time (Finding)" + }, + { + "input": "Definition: Country described as numerous islands scattered over more than three-quarters of a million square kilometers of ocean that are a territory of Australia and located in Oceania, northeast of Austrualia.\nConcepts: Borderline Ovarian Clear Cell Cystadenofibroma (Borderline Ovarian Clear Cell Adenofibroma)\tCoral Sea Islands (Geographic Area)\theparan sulfate proteoglycan breakdown (heparan sulfate proteoglycan metabolic process)\tL-Valinamide, N2-(((1-carboxy-2-phenylethyl)amino)carbonyl)-L-arginyl-N-(4-((aminoiminomethyl)amino)-1-formylbutyl)- (Pharmacologic Substance)\tDevice Slipped (Finding)", + "output": "Coral Sea Islands (Geographic Area)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of mitotic cohesin ssDNA (lagging strand) loading.\nConcepts: positive regulation of mitotic cohesin ssDNA (lagging strand) loading (regulation of mitotic cohesin ssDNA (lagging strand) loading)\tFAC07105 (Intellectual Product)\tFGF-8 (FGF8 gene)\tVulvar Cancer pN2c TNM Finding v7 (Vulvar Cancer pN2 TNM Finding v7)\tpositive regulation of gonadotrophin secretion (positive regulation of hormone secretion)", + "output": "positive regulation of mitotic cohesin ssDNA (lagging strand) loading (regulation of mitotic cohesin ssDNA (lagging strand) loading)" + }, + { + "input": "Definition: something described as a chronic myelomonocytic leukemia characterized by the presence of less than 5 percent blasts in the bone marrow and less than 2 percent blasts in the peripheral blood.\nConcepts: Pericardial Spaces (Pericardial sac structure)\tcentral demyelination of corpus callosum (Leukoencephalopathy)\tChronic Myelomonocytic Leukemia-0 (Leukemia, Myelomonocytic, Chronic)\tParabacteroides Sakamoto and Benno 2006 (Tannerellaceae)\tg/ml/m2 (Unit of concentration)", + "output": "Chronic Myelomonocytic Leukemia-0 (Leukemia, Myelomonocytic, Chronic)" + }, + { + "input": "Definition: Wolinella described as a species of microaerophilic, Gram-negative, curved or spiral bacilli assigned to the phylum Proteobacteria. This species is motile using a single polar flagellum, non-spore forming, oxidase positive, catalase negative and produces both formate and acetate. C. curvus, formerly known as Wolinella curva, is a rare pathogen associated with cases of bloody and Brainerd's diarrhea.\nConcepts: Wolinella curva -RETIRED- (Wolinella)\tEczema;atopic (Dermatitis and eczema)\tEZH2 inhibitor CPI-0209 (Pharmacologic Substance)\ttransforming growth factor beta receptor signaling pathway involved in primitive streak formation (TGF-Beta Receptor Signaling Pathway)\tGrade 5 Neonatal Rash, Adverse Event (Finding)", + "output": "Wolinella curva -RETIRED- (Wolinella)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hepatocyte growth factor.\nConcepts: CK measurement (Serum chemistry test)\tCetuximab-loaded Polymeric Nanoparticles Decorated With Octreotide (Antineoplastic Antibody)\tDisease;blood (Blood, Heart and Circulation)\tVasodilation (positive regulation of blood vessel diameter)\tregulation of hepatocyte growth factor anabolism (Molecular Function)", + "output": "regulation of hepatocyte growth factor anabolism (Molecular Function)" + }, + { + "input": "Definition: YMRS Questionnaire Question described as young Mania Rating Scale (YMRS) Disruptive-aggressive behaviour.\nConcepts: Pirimicarb (Carbamate insecticide)\tEnvironmental Setting (ParameterizedDataType - CodeSystem)\tYMRS - Disruptive-Aggressive Behaviour (YMRS Questionnaire Question)\tTumor Expansion (Neoplastic Process)\tF-MACHOP Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)", + "output": "YMRS - Disruptive-Aggressive Behaviour (YMRS Questionnaire Question)" + }, + { + "input": "Definition: Activity described as acknowledgement that funding support is from any non-US government agency, for example state and local governments, foreign governments, and private organizations.\nConcepts: Gap Junction Protein (Membrane Transport Proteins)\tcofermentation of pairs of amino acids (Molecular Function)\tgeranium maculatum/cranesbil (Western herbs and natural substances letter G)\tSATOREOTIDE TRIZOXETAN GALLIUM GA-68 (Amino Acid, Peptide, or Protein)\tSupport, Non-U.S. Gov't (Activity)", + "output": "Support, Non-U.S. Gov't (Activity)" + }, + { + "input": "Definition: B [Preparations] described as an enzyme found in pineapples that breaks down other proteins, such as collagen and muscle fiber, and has anti-inflammatory properties. It is used as a meat tenderizer in the food industry.\nConcepts: Specify NF1 Mutation (Specify Identified Mutation)\thexafluoridosulfur (Medical gases)\ttherapy, interferon (Cytokine therapy)\tbromelains (pancrelipase)\tOncolytic Adenovirus Ad5-yCD/mutTKSR39rep-hIL12 (Adenovirus Vaccine)", + "output": "bromelains (pancrelipase)" + }, + { + "input": "Definition: chimeric colonial development described as development of a non-reproductive fruiting body formed by aggregation of cells with different genotypes.\nConcepts: Gravid Uterus Adjusted Body Weight (Body Weight)\tGrade 3 Edema Limbs, CTCAE (Edema Limbs, CTCAE 5)\tTSQM Version 1.4 - Confident Medication Is Good for You (Intellectual Product)\tchimeric non-reproductive fruiting body development (Organism Function)\tPlacental Schultze Mechanism (Finding During Childbirth Labor)", + "output": "chimeric non-reproductive fruiting body development (Organism Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420.\nConcepts: Neonatal Respiratory Insufficiency, Adverse Event (Finding)\tglucuronate-2-sulfatase activity (Molecular Function)\thydrogen:coenzyme F420 oxidoreductase activity (oxidoreductase activity, acting on hydrogen as donor, with other known acceptors)\tdivalent inorganic cation homeostasis (Physiologic Function)\tNevi (Disease of Skin and Appendages)", + "output": "hydrogen:coenzyme F420 oxidoreductase activity (oxidoreductase activity, acting on hydrogen as donor, with other known acceptors)" + }, + { + "input": "Definition: HCPCS Level I Preferred Terms, Obsolete described as a measurement of the glutamine in a biological specimen.\nConcepts: Stereotactic Systems, Image-Guided, Surgical, Multiprocedure (Medical Device)\tregulation of lysosomal membrane permeability (regulation of membrane permeability)\tfunctions reproductive (body system or organ function)\tGlutamine Test (Laboratory Procedure)\tEXCAT (Categories)", + "output": "Glutamine Test (Laboratory Procedure)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in).\nConcepts: ASEX0103 (Intellectual Product)\tDental Materials, Caries Detection, Dye (Dental Materials)\tnegative regulation of T cell apoptosis (regulation of T cell apoptotic process)\tpurine-specific nucleoside:sodium symporter activity (Molecular Function)\t9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)- (Antimetabolites)", + "output": "purine-specific nucleoside:sodium symporter activity (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as a subjective response indicating that something is a minor difficulty requiring resolution.\nConcepts: Dryers, X-Ray Film (Device associated with radiographic films)\ttrans-3,4-dihydrodiolphenanthrene sulfotransferase activity (Molecular Function)\tOnly Very Slight Problem (Intellectual Product)\tnegative regulation by symbiont of host immune response (modulation by symbiont of host immune response)\tBiphenyldiamines (Organic Chemical)", + "output": "Only Very Slight Problem (Intellectual Product)" + }, + { + "input": "Definition: Abnormal Cells Present described as a morphologic finding indicating the presence of malignant epithelial cells with cytoplasmic vacuoles or flocculent cytoplasmic inclusions containing wispy eosinophilic material giving a bubbly appearance.\nConcepts: Chiropractic Providers; Chiropractor, Independent Medical Examiner (Professional or Occupational Group)\tpolarized secretion of basement membrane proteins in epithelium (basement membrane constituent secretion)\tSpatial Processings, Auditory (Mental Process)\tMalignant Epithelial Cells with Cytoplasmic Vacuoles or Flocculent Cytoplasmic Inclusions Containing Wispy Eosinophilic Material Present (Abnormal Cells Present)\tphosphatidylinositol-3,4-bisphosphate binding (Molecular Function)", + "output": "Malignant Epithelial Cells with Cytoplasmic Vacuoles or Flocculent Cytoplasmic Inclusions Containing Wispy Eosinophilic Material Present (Abnormal Cells Present)" + }, + { + "input": "Definition: Expression Negative described as an indication that PAX5 expression has not been detected in a sample.\nConcepts: Arresting (Action)\tC22:1, n-9 trans (Trans Fatty Acids)\tPaired Box Protein Pax-5 Negative (Laboratory or Test Result)\tIn between (Topographical modifier)\tCortical Nephron (Body Part, Organ, or Organ Component)", + "output": "Paired Box Protein Pax-5 Negative (Laboratory or Test Result)" + }, + { + "input": "Definition: Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Rest tremor amplitude left upper extremity.\nConcepts: Phenyl Ethers (Ethers)\tAirway Obstructions (Larynx)\tTIMI Thrombus Grade (Clinical Classification)\tP450 omega-hydroxylase pathway (arachidonic acid metabolic process)\tUPD2317B (MDS-UPDRS Questionnaire Question)", + "output": "UPD2317B (MDS-UPDRS Questionnaire Question)" + }, + { + "input": "Definition: something described as any fungal organism that can be assigned to the species Clavispora lusitaniae.\nConcepts: PROPIONYL-CoA CARBOXYLASE DEFICIENCY (Finding)\tCandida parapsilosis var obtus (Class Ascomycetes)\tfolliculinum/ovarian follicl (Pharmacologic Substance)\t7,8-dihydropteroate:L-glutamate ligase (Molecular Function)\tCreatine Kinase MM/Total Creatine Kinase (Laboratory Procedure)", + "output": "Candida parapsilosis var obtus (Class Ascomycetes)" + }, + { + "input": "Definition: something described as an injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration, the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed on a wide range of primary and metastatic human cancers.\nConcepts: ION CHANNEL K (Biologically Active Substance)\tRecurrent Multiple Myeloma/Plasma Cell Myeloma (Recurrent Lymphoproliferative Disorder)\tFolate Receptor-Targeting Folate-Tubulysin Conjugate EC1456 (Tubulin Binding Agent)\tWilms Tumor Genes (Tumor Suppressor Genes)\tMusculoskeletal Chest Pain (Musculoskeletal and connective tissue pain and discomfort)", + "output": "Folate Receptor-Targeting Folate-Tubulysin Conjugate EC1456 (Tubulin Binding Agent)" + }, + { + "input": "Definition: Global mental functions described as general mental functions, as they develop over the life span, required to understand and constructively integrate the mental functions that lead to the formation of the interpersonal skills needed to establish reciprocal social interactions, in terms of both meaning and purpose.\nConcepts: Global psychosocial functions (Mental Process)\tdisorders musculoskeletal (Disorder of body system)\tStratification (Clinical Trials Design)\tupregulation of gonadotropin secretion (positive regulation of hormone secretion)\trhythmic synaptic transmission (Organ or Tissue Function)", + "output": "Global psychosocial functions (Mental Process)" + }, + { + "input": "Definition: Vaccines described as a vaccine containing bacillus Calmette-Guerin (BCG), an attenuated strain of Mycobacterium bovis, with non-specific immunoadjuvant and immunotherapeutic activities. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG vaccine likely activates a Th1 cytokine response that includes the induction of interferon. Vaccination with BCG vaccine may be immunoprotective against infection with Mycobacterium tuberculosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C298\" active clinical trials using this agent.\nConcepts: Bacillus Calmette-Guerin (neoplasm/cancer vaccine)\tEmpty Sella Syndromes (Central Nervous System)\tBrachial plexus (Brachial plexus structure)\tcyclosporin (Ophthalmic Agents, Other)\tPost-cohabitation (Temporal Concept)", + "output": "Bacillus Calmette-Guerin (neoplasm/cancer vaccine)" + }, + { + "input": "Definition: Quantitative Concept described as a logarithmic-scale (base 10) unit for measuring concentration and/or reactivity of a test substance (an antigen or antibody of interest) as defined in the literature reference for the particular quantitative enzyme-linked immunosorbent assay method.\nConcepts: Visual field scotoma (Finding of visual field)\ttranslation (protein expression)\t{Log10}.[ELU] (Enzyme-Linked Immunosorbent Assay Unit)\tAltered sexuality patterns (rndx role relationship)\tRearrangement of 6p25 (Cell or Molecular Dysfunction)", + "output": "{Log10}.[ELU] (Enzyme-Linked Immunosorbent Assay Unit)" + }, + { + "input": "Definition: Monobactams described as group of broad spectrum antibiotics which share the nucleus 7-aminocephalosporanic acid; antibacterial activity results from inhibition of the cross linking of peptidoglycan units in the cell wall.\nConcepts: Eye Drop Comfort Grade (Grade)\tGrade 4 Anal Ulcer, CTCAE (Finding)\tCephalosporins (ANTI-INFECTIVE AGENTS FOR BACTERIA, VIRUSES AND FUNGI)\tM130 (CD163 gene)\tthylakoid light-harvesting complex location (Cell Component)", + "output": "Cephalosporins (ANTI-INFECTIVE AGENTS FOR BACTERIA, VIRUSES AND FUNGI)" + }, + { + "input": "Definition: Organic Chemical described as a polychlorinated compound used for controlling a variety of insects. It is practically water-insoluble, but readily adheres to clay particles and persists in soil and water for several years. Its mode of action involves repetitive nerve-discharges positively correlated to increase in temperature. This compound is extremely toxic to most fish. (From Comp Biochem Physiol (C) 1993 Jul;105(3):347-61)\nConcepts: Thiodan (Organic Chemical)\tOEDEMA PULMONARY (CIRCULATION COMPONENT)\tBarrington nucleus (Body Part, Organ, or Organ Component)\tED202 3 (Expanded DRS-PI Survivor Version Questionnaire Question)\tMART-1:26-35(27L) peptide vaccine (Immunologic Factor)", + "output": "Thiodan (Organic Chemical)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements.\nConcepts: Myeloproliferative Leukemia Virus, Mouse, Homolog of Gene (MPL gene)\tPrimary undifferentiated carcinoma of endometrium (Endometrial Carcinoma)\tscience of microbiology (biology)\tinferior olivary nucleus development (Organ or Tissue Function)\tTumor Protein p53 Gene Deletion (Gene Deletion Abnormality)", + "output": "inferior olivary nucleus development (Organ or Tissue Function)" + }, + { + "input": "Definition: supramolecular fiber described as a component of the cytoskeleton consisting of a homo or heteropolymeric fiber constructed from an indeterminate number of protein subunits.\nConcepts: Epigenomic (Genomics)\tSubcutaneous Port Injection Needles (NEEDLES,INJECTION)\testablishment of vesicle localisation (Cell Function)\tpolymeric cytoskeletal fiber (Cell Component)\tregulation of mRNA alternative polyadenylation (Genetic Function)", + "output": "polymeric cytoskeletal fiber (Cell Component)" + }, + { + "input": "Definition: something described as a group of nerve cells caudal to the red nucleus in the midbrain of the human ( Riley-1943 ).\nConcepts: Nucleus motorius tegmento-bigeminalis (Body Part, Organ, or Organ Component)\tPain Score 6 (Finding)\tCLSTW (Last Concentration)\tPerformedProductInvestigationResult.evaluationConclusionCode (Evaluation Conclusion Code)\tCDISC SEND Study Type Terminology (Intellectual Product)", + "output": "Nucleus motorius tegmento-bigeminalis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as diode lasers designed for thermal ablation of subcutaneous or deeper tissue; they usually include a high power (typically 40 to 60 W at a wavelength from 800 to 1,000 nm) diode laser generator and applicators that are inserted into the tissue to be ablated (e.g., tumor). Laser energy may be applied directly using either a bare fiber or a special diffuser tip (e.g., ring-mode or isotropic) as an applicator. Interstitial thermotherapy diode lasers are mostly used for percutaneous ablation of deep-seated tumors by coagulation necrosis at temperatures over 60 degrees C. Some systems use magnetic resonance imaging as a guide to locate the applicator and to evaluate the thermal results; other systems include thermal sensors and a computer programmed to regulate laser energy to keep the tissue temperature (e.g., tumor) within a prespecified range. Some of these lasers may also be used for hyperthermia procedures at temperatures from 42 to 45 degrees C (108 to 113 degrees F) to treat solid malignant tumors; most procedures combine hyperthermia with ionizing radiation (thermoradiotherapy) or chemotherapy (thermochemotherapy).\nConcepts: Lasers, Diode, Interstitial Thermotherapy (Lasers, Semiconductor)\tenthesopathies (Arthropathy)\t1H-Pyrazol-3-amine, 4,5-dihydro-1-(3-(trifluoromethyl)phenyl)- (Pharmacologic Substance)\tArmenian S.S.R. (Country)\tIVD Panels, Human Genetics, Metabolic Disorder, Lysosomal Storage Disease, Lipidosis, Berardinelli-Seip Lipodystrophy (IVD Panels, Human Genetics, Metabolic Disorder, Lysosomal Storage Disease, Lipidosis)", + "output": "Lasers, Diode, Interstitial Thermotherapy (Lasers, Semiconductor)" + }, + { + "input": "Definition: something described as a state in the mid-atlantic United States. Its capital is Harrisburg.\nConcepts: Pain in head and neck (Pain in body part)\tVITREORETINOPATHY, NEOVASCULAR INFLAMMATORY, AUTOSOMAL DOMINANT (Hereditary Connective Tissue Disorder)\tDinutuximab product (Immunologic Factor)\tPennsylvania (Mid-Atlantic Region)\tsuccinyl coenzyme A synthetase (adenosine diphosphate-forming) activity (succinate-CoA ligase activity)", + "output": "Pennsylvania (Mid-Atlantic Region)" + }, + { + "input": "Definition: alcohol dehydrogenase (cytochrome c(L)) activity described as catalysis of the reaction: ethanol + 2 cytochrome c(L) = acetaldehyde + 2 reduced cytochrome c(L) + 2 H+.\nConcepts: Early Interceptive Treatment (Orthodontic procedure)\thistone H4-K16 deacetylation (Molecular Function)\tcongenital pseudoarthrosis tibia (Congenital pseudoarthrosis of limb)\tOleandomycin - chemical (Macrolide Antibiotics)\tethanol cytochrome-c oxidoreductase activity (Molecular Function)", + "output": "ethanol cytochrome-c oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Gram-Positive Asporogenous Rods, Irregular described as a genus of asporogenous bacteria that is widely distributed in nature. Its organisms appear as straight to slightly curved rods and are known to be human and animal parasites and pathogens.\nConcepts: Screening (Interventional procedure)\tcorynebacterium (BACTERIA AND RICKETTSIAE)\tEDQM-HC Units of Presentation Terminology (EDQM Health Care Terminology)\tleft ventricular myocardium morphogenesis (ventricular cardiac muscle tissue morphogenesis)\tBoNT/F2 (botulinum toxin type F)", + "output": "corynebacterium (BACTERIA AND RICKETTSIAE)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study - Initial/first attempt actual lethality/medical damage.\nConcepts: CSS03-First Attempt Damage (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tselective angioblast sprouting (Organ or Tissue Function)\tUnknown Outcome (Finding)\tin vitro (Qualitative Concept)\tBPRS01-Motor Retardation (BPRS 1988 Version Clinical Classification Question)", + "output": "CSS03-First Attempt Damage (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)" + }, + { + "input": "Definition: status by occupation described as a person licensed, certified or otherwise authorized or permitted by law to administer healthcare in the ordinary course of business or practice of a profession. EXAMPLE(S): Physician, Physician Assistant, Psychologist, Nurse, Physical Therapist OTHER NAME(S): NOTE(S):\nConcepts: Grade 1 Esophageal Hemorrhage, CTCAE (Finding)\tGrade 4 Fallopian Tube Anastomotic Leak, CTCAE (Fallopian Tube Anastomotic Leak, CTCAE)\tDDS0118 (Intellectual Product)\thealth professionals (Professional Personnel)\tPeriod, Intraoperative (Operative Surgical Procedures)", + "output": "health professionals (Professional Personnel)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Screening - Have you actually had any thoughts of killing yourself?\nConcepts: Joint Task Force Type 1 Myocardial Infarction (Finding)\tHIF-1alpha inhibitor PX-478 (Antineoplastic Agents)\tLong collarbone (Ribs, sternum, clavicles, and scapulae)\tCSS09-Non-Spec Suicid Thought (Intellectual Product)\tresponse to hydroperoxide (Cell Function)", + "output": "CSS09-Non-Spec Suicid Thought (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as chromatin assembly factor 1 subunit A (956 aa, ~107 kDa) is encoded by the human CHAF1A gene. This protein plays a role in replication-dependent nucleosome assembly.\nConcepts: Renal Adenocarcinomas (Neoplasms)\tmin.umol/l/(mg/g) (Measurement Unit Description)\tMeningioangiomatosis (Central Nervous System Vascular Malformations)\tChromatin Assembly Factor I (Amino Acid, Peptide, or Protein)\tMalignant endocrine neoplasm NOS (body system/site cancer)", + "output": "Chromatin Assembly Factor I (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: DKFZp779G1236 (PCLO gene)\tRetinal nerve fibre oedema (Pathologic Function)\tcell proliferation in dorsal spinal cord (Cell Function)\tAbnormal ossification of the pubic bone (Abnormality of the pubic bone)\tSAW, MANUAL AND ACCESSORIES (Medical Device)", + "output": "SAW, MANUAL AND ACCESSORIES (Medical Device)" + }, + { + "input": "Definition: something described as a cellular protein localization process in which a protein is transported to, or maintained at, the site of cell division following cytokinesis.\nConcepts: sepal giant cell differentiation (plant epidermal cell differentiation)\tprotein localization to cell division site after cytokinesis (Cell Function)\t9q34.13 (Cell Component)\tNominal Scale (Intellectual scale)\tPedsQL Neuromuscular Module Acute Version 3.0 Young Child Report - Hard to Use Bathroom (Intellectual Product)", + "output": "protein localization to cell division site after cytokinesis (Cell Function)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as auditory Verbal Learning Test Version A - List A, Recall 2, Word 1.\nConcepts: Capnocytophaga ochracea (Prevot et al. 1956) Leadbetter et al. 1982 (Capnocytophaga)\tAVL01018 (Intellectual Product)\tCatheters, Percutaneous Oxygen (Medical Device)\tSPR210 (Gene or Genome)\tLNP Encapsulated Human IL-12A/IL-12B mRNAs MEDI-1191 (Gene Transfer or Gene Delivery Agent)", + "output": "AVL01018 (Intellectual Product)" + }, + { + "input": "Definition: PTPRB gene described as human PTPRB wild-type allele is located within 12q15-q21 and is approximately 121 kb in length. This allele, which encodes receptor-type tyrosine-protein phosphatase beta protein, plays a role in both the removal of phosphate groups from phosphotyrosine and blood vessel maintenance.\nConcepts: Protein-Tyrosine Phosphatase, Receptor-Type, B Gene (PTPRB gene)\tGas Chromatography/Flame Ionization Detector (Gas Chromatography)\tdocosapentaenoic acid (Biologically Active Substance)\tTdT positive ALL, adult (TdT Positive Acute Lymphoblastic Leukemia)\tevening primrose (Tracheophyta)", + "output": "Protein-Tyrosine Phosphatase, Receptor-Type, B Gene (PTPRB gene)" + }, + { + "input": "Definition: Biologically Active Substance described as interleukin-34 (242 aa, ~27 kDa) is encoded by the human IL34 gene. This protein plays a role in binding to macrophage colony-stimulating factor 1 receptor and the induction of receptor signaling.\nConcepts: Type 1 Collagen X-link N-Telopeptides to Creatinine Ratio Measurement (Urine protein test)\tsmall cell cancer of the cervix (Extrapulmonary Small Cell Carcinoma)\tVentricular Septal Defect Closure Device (Medical Devices)\tIL-34 protein, human (Biologically Active Substance)\tProtein Export Pathway (Transport Pathway)", + "output": "IL-34 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Cerebral cortex described as one of two types of cerebral cortex defined on the basis of cytoarchitecture and fetal development. The other is allocortex. Neocortical areas pass through a six-layered stage in the third semester of gestation. Most retain six layers into adulthood and are called homotypic cortex. A few undergo modification to more or less than six layers and are called heterotypic cortex. Starting from the cortical surface the basic layers are: molecular layer of the cerebral cortex (I), external granular layer (II), external pyramidal layer (III), internal granular layer (IV), internal pyramidal layer (V), and multiform layer (VI). Neocortex is most prominent in the frontal lobe, the parietal lobe, the temporal lobe and the occipital lobe, less so in the cingulate gyrus, the parahippocampal gyrus and the insula. Also known as 'isocortex', the neocortex is composed of two subdivisions: true isocortex and proisocortex ( Carpenter-1983 ). In the human it constitutes 96% of the surface area of the cerebral cortex ( Zilles-1990 ),\nConcepts: FAC02902 (Intellectual Product)\tSCSTRESU (Quantitative Concept)\tAMPLSZ (size)\tProthrombin Deficiency (Hemorrhagic Disorders)\tSubstantia Corticalis (Region of cerebral cortex)", + "output": "Substantia Corticalis (Region of cerebral cortex)" + }, + { + "input": "Definition: Computer Applications described as computerized compilations of information units (text, sound, graphics, and/or video) interconnected by logical nonlinear linkages that enable users to follow optimal paths through the material and also the systems used to create and display this information.\nConcepts: FAC006-Satisfied Communication Illness (FACT-BL Version 4 Questionnaire Question)\tVentilated Cigarette (Cigarette)\tHypermedium (Intellectual Product)\tsnoRNA guided rRNA pseudouridine synthesis (Genetic Function)\tCD 028 ANTIGENS (T-Cell Receptor)", + "output": "Hypermedium (Intellectual Product)" + }, + { + "input": "Definition: Abnormal renal medulla morphology described as the presence of many cysts in the medulla of the kidney.\nConcepts: DNA translocase activity (DNA dependent adenosinetriphosphatase activity)\tMultiple small medullary renal cysts (Renal cyst)\tDistressed by Awakening in the Early Morning (Intellectual Product)\tSUTURE (Biomedical or Dental Material)\tpositive regulation of neuron projection branching (regulation of neuron projection arborization)", + "output": "Multiple small medullary renal cysts (Renal cyst)" + }, + { + "input": "Definition: Intellectual Product described as life Events Checklist for DSM-5, Standard Version - Captivity (for example, being kidnapped, abducted, held hostage, prisoner of war): Part of my job.\nConcepts: zygotic specification of dorsal/ventral axis (dorsal/ventral axis specification)\tTelomerase RNA Component wt Allele (TERC gene)\twriting micrographia (Hand)\tLEC-5 Standard Version - Captivity: Job (LEC-5 Standard Version Questionnaire Question)\tHAMD 17 (Clinical Classification)", + "output": "LEC-5 Standard Version - Captivity: Job (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Skeletal System Part described as a normal anteroinferior concavity of the sacrum and coccygeal vertebrae, extending from the lumbosacral junction to the apex of the coccyx.\nConcepts: Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm (Liver and Intrahepatic Bile Duct Neoplasm)\tPelvic Curve (Body Part, Organ, or Organ Component)\tvaginismus (Disease or Syndrome)\tNIEHS (Health Care Related Organization)\tADCOFO06 (Intellectual Product)", + "output": "Pelvic Curve (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of protein polyubiquitination.\nConcepts: Lubinsky syndrome (Hereditary disorder of the visual system)\tregulation of protein polyubiquitinylation (Molecular Function)\tPterygium colli and mental retardation with facial and digital anomalies (Hereditary disorder of the integument)\t3-(4-hydroxyphenyl)-2H-chromen-7-ol (Organic Chemical)\tGrade 4 Small Intestinal Anastomotic Leak, CTCAE (Finding)", + "output": "regulation of protein polyubiquitinylation (Molecular Function)" + }, + { + "input": "Definition: something described as a severe form of congenital disorders of N-linked glycosylation characterized by severe developmental and psychomotor delay, muscular hypotonia, intractable early-onset seizures, and microcephaly. Additional features include altered blood coagulation with a high probability of hemorrhages or thromboses, nephrotic syndrome, ascites, hepatomegaly, cardiomyopathy, ocular manifestations (strabismus, nystagmus), and immunodeficiency. The disease is caused by loss-of-function mutations in the gene ALG1 (16p13.3).\nConcepts: Carbohydrate deficient glycoprotein syndrome type Ik (Disease or Syndrome)\tCaribou (Deer)\tSet of splenic lymph nodes (Abdominal lymph node group)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MTM1 (Medical Device)\tMLANA Positive (Laboratory or Test Result)", + "output": "Carbohydrate deficient glycoprotein syndrome type Ik (Disease or Syndrome)" + }, + { + "input": "Definition: negative regulation of alkane biosynthetic process described as any process that stops, prevents or reduces the frequency, rate or extent of heptadecane biosynthetic process.\nConcepts: FoodProduct.stabilityDuration (Stability Duration)\tProject Conduct (Research Activity)\tUPSTREAM TRANSCRIPTION FACTOR 1 (Gene or Genome)\tFIBROBLAST GROWTH FACTOR RECEPTOR SUBSTRATE 2 (Gene or Genome)\tnegative regulation of heptadecane biosynthetic process (regulation of heptadecane biosynthetic process)", + "output": "negative regulation of heptadecane biosynthetic process (regulation of heptadecane biosynthetic process)" + }, + { + "input": "Definition: something described as the determination of the ratio of taurine compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Hydrocodone (Opioids)\tTaurine/Creatinine (Urine protein test)\tMacropain (Hydrolase)\tTemporomandibular muscle massage each 15 minutes (Massage)\tepithelial cell morphogenesis (Cell Function)", + "output": "Taurine/Creatinine (Urine protein test)" + }, + { + "input": "Definition: Simulators, Environmental Detector/Monitor, Chemical Agent described as chemical agent detector and/or monitor simulators designed to detect a nonhazardous chemical simulant with characteristics similar to the hazardous agent. Chemical agent simulators may detect and/or monitor either liquid or powder simulants. The simulants can be mixed to produce simulant contaminants of different consistencies (e.g., water, oil); several technologies are used for this purpose (e.g., fluorescence). These simulators are used to simulate chemical detectors and/or monitors during training, both for contamination detection and decontamination procedures, without using the real contaminants.\nConcepts: Purinoceptor Agonists, P2Y (Pharmacologic Substance)\tEarly Pregnancy Symptom (Sign or Symptom)\tPalpable Masses Completion Status (Completion Status)\tphotosystem II antenna complex location (Cell Component)\tSimulators, Environmental Detector/Monitor, Chemical Agent, Chemical Simulant (Simulators, Environmental Detector/Monitor, Chemical Agent)", + "output": "Simulators, Environmental Detector/Monitor, Chemical Agent, Chemical Simulant (Simulators, Environmental Detector/Monitor, Chemical Agent)" + }, + { + "input": "Definition: Physics described as its fundamental principle is that any physical system can be decomposed into a collection of simple independent local elements each of which interacts only with its immediate neighbors. In classical mechanics a complete description of any physical system is supposed to be specified by giving the values of the various fields (e.g., the electric field, the magnetic field, etc.) at each of the relevant spacetime points.\nConcepts: Neurological Development Terminology (NICHD Terminology)\tCSF1R gene (Cytokine Receptor Gene)\tN3 Regional Lymph Node Stage Finding (TNM classification of malignant tumor before any treatment)\tnegative regulation of lymphotoxin A synthesis (negative regulation of lymphotoxin A production)\tClassical Mechanics (Occupation or Discipline)", + "output": "Classical Mechanics (Occupation or Discipline)" + }, + { + "input": "Definition: Molecular Genetic Technique described as the insertion of genetic material into a cell.\nConcepts: Porphyrin (AMINO ACIDS PORPHYRINS)\tGene Transfer (Molecular Genetic Technique)\tEsperamycin (Enediyne Antineoplastic Antibiotic)\tBehavioral Genetics (Psychobiology)\tCDRS-R - Depressed Feelings Comment (Intellectual Product)", + "output": "Gene Transfer (Molecular Genetic Technique)" + }, + { + "input": "Definition: something described as research aimed at assessing the quality and effectiveness of particular health care practices and interventions as measured by the attainment of a specified end result; for complete retrieval include RTs.\nConcepts: DMSMFH (Disease or Syndrome)\tHealth Outcomes Research (Research Activity)\tvocal folds (Body part)\tPediococcus pentosaceus (Pediococcus)\tMAGE-A1, MAGE-A3, NY-ESO-1 peptides vaccine (Pharmacologic Substance)", + "output": "Health Outcomes Research (Research Activity)" + }, + { + "input": "Definition: Surgical Instruments described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system (Physiologic Function)\tChemotherapy Course 5 (Therapeutic or Preventive Procedure)\tRasp, device (Medical Device)\tPromonocytes (Laboratory Procedure)\thealth care financing (Medical Economics)", + "output": "Rasp, device (Medical Device)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 11q\nConcepts: Maternal great grandfather (Great grandfather)\tOvarian, Fallopian Tube, and Primary Peritoneal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)\t11q14-q21 (Chromosome band)\tFenilpropanolamina (Adrenergic Agents)\tSFG.CAR.CD30 autologous T lymphocytes (Cell)", + "output": "11q14-q21 (Chromosome band)" + }, + { + "input": "Definition: Professional Organization or Group described as a United Nations agency established to coordinate international health activities and to help governments improve health services.\nConcepts: ORGAN WORLD HEALTH (Professional Organization or Group)\tAscending aortic dissection (Abnormal ascending aorta morphology)\thost cell viral assembly compartment (cytoplasmic viral factory)\tExposure Dosing Frequency per Interval (Intellectual Product)\tFocal auditory seizure (Finding)", + "output": "ORGAN WORLD HEALTH (Professional Organization or Group)" + }, + { + "input": "Definition: Polyunsaturated Fatty Acids described as a polyunsaturated long-chain fatty acid with a 16-carbon backbone and exactly 3 double bonds. There are at least 5 separate isomers that could be called by this name.\nConcepts: negative regulation of glomerular filtration by angiotensin (negative regulation of renal output by angiotensin)\tState (Geographic state)\tThrowing Up or Feeling Like May Throw Up (Clinical or Research Assessment Question)\t11pter-p13 (Chromosome band)\tFatty Acid 16:3 (Polyunsaturated Fatty Acids)", + "output": "Fatty Acid 16:3 (Polyunsaturated Fatty Acids)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as the National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Prostate Symptom Index 17 Version 2 test code.\nConcepts: dinucleotide repeat insertion binding (dinucleotide insertion or deletion binding)\tQS-NCCN-FACT-FPSI 17 Version 2 TESTCD (Intellectual Product)\tPost partum Thyroiditis (Puerperal Disorders)\tAnatomic Rim (Body Part, Organ, or Organ Component)\tMedullary Thyroid Carcinoma pN1 TNM Finding v8 (Finding)", + "output": "QS-NCCN-FACT-FPSI 17 Version 2 TESTCD (Intellectual Product)" + }, + { + "input": "Definition: tissue/cell culture described as culturing of normal cells or tissues with different normal cells or tissues; also includes culturing of normal cells or tissues with infected or latently infected cells or tissues of the same kind.\nConcepts: Iodipamide (Contrast Media)\tmixed tissue/cell culture (tissue/cell culture)\tAV Block Second Degree M\u00f6bitz Type I Adverse Event (Cardiac Disorders, CTCAE)\tLexatumumab (Monoclonal Antibodies)\thistone pre-mRNA stem-loop binding (Genetic Function)", + "output": "mixed tissue/cell culture (tissue/cell culture)" + }, + { + "input": "Definition: something described as this gene is involved in transport.\nConcepts: IL-9 (cytokine binding)\tSEC14-like lipid binding 1 (Gene or Genome)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ATP7B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tinward migration of deep nuclear neurons (cell migration in hindbrain)\tClip Appliers, Vascular, Reusable, Aneurysm (Medical Device)", + "output": "SEC14-like lipid binding 1 (Gene or Genome)" + }, + { + "input": "Definition: Abnormal Tissue Present described as a morphologic finding that refers to the presence of ectopic white matter in a tissue sample.\nConcepts: peripheral B lymphocyte negative selection (B cell negative selection)\tCongenital myosclerosis Lowenthal type (Disorder of skeletal muscle)\tInfection, subclinical (Infection)\tEntrapped White Matter Present (Finding)\tX: 50486820-50492643 (Spatial Concept)", + "output": "Entrapped White Matter Present (Finding)" + }, + { + "input": "Definition: Equipment and Supplies described as instruments that generate intermittent forces, uniformed or graduated, to facilitate the emptying of VEINS. These devices are used to reduce limb EDEMA and prevent venous THROMBOEMBOLISM, such as deep vein thrombosis in the legs.\nConcepts: Testing, Molecular (Molecular Analysis)\tSteroids, Plant (Lipids)\tImmunoblastic Lymphoma of Thyroid (Thyroid Diffuse Large B-Cell Lymphoma)\tCompression Devices, Intermittent Pneumatic (Clinical equipment and/or device)\tcolostrums (Breast)", + "output": "Compression Devices, Intermittent Pneumatic (Clinical equipment and/or device)" + }, + { + "input": "Definition: Immunologic Factor described as c-X-C motif chemokine 5 (114 aa, ~12 kDa) is encoded by the human CXCL5 gene. This protein is involved in both chemotaxis and activation of neutrophils.\nConcepts: albino (Rare Non-Neoplastic Disorder)\tENA-78(1-78) (Immunologic Factor)\tfibronectin-dependent thymic lymphocyte migration (Cell Function)\tteichuronic acid synthesis (organic acid biosynthetic process)\tErionite (Minerals and ores)", + "output": "ENA-78(1-78) (Immunologic Factor)" + }, + { + "input": "Definition: something described as an impairment of the ability to track objects with the ocular smooth pursuit system, a class of rather slow eye movements that minimizes retinal target motion.\nConcepts: SDTM-SPECTYPE (CDISC SDTM Terminology)\tImpaired smooth pursuit (Finding)\tESRSA1-Dyskinesia: Hips/Lower Limbs/Feet (ESRS-A Clinical Classification Question)\tFoetal cardiac monitor (electrode)\tLENS, CONTACT, FOR COLOR VISION DEFICIENCY (Medical Device)", + "output": "Impaired smooth pursuit (Finding)" + }, + { + "input": "Definition: Health Care Activity described as an appraisal or evaluation of a patient's condition by a physician or registered nurse, based on clinical and laboratory data, medical history, and the patient's account of symptoms. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C25305\" active clinical trials using this agent.\nConcepts: TSQM Version 1.4 - Interfere With Mental Function (Intellectual Product)\texam medical (Personal assessment)\tIIEF01-Penetration Ability (Intellectual Product)\tLeft fibrous trigone of heart (Body Part, Organ, or Organ Component)\targonaute siRNA chaperone complex location (RNAi effector complex)", + "output": "exam medical (Personal assessment)" + }, + { + "input": "Definition: Organic Chemical described as a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents.\nConcepts: Nimodipine (Organic Chemical)\tBF-Diary (Intellectual Product)\tbreast ductal hyperplasia (Breast hyperplasia)\t8: 95976660-95961628 (Spatial Concept)\tsyntrophin complex (plasma membrane protein complex)", + "output": "Nimodipine (Organic Chemical)" + }, + { + "input": "Definition: Dermatologic disorders described as symmetric ringed creases around the extremities which disappear later in life. They are reminiscent of these of the mascot of the tire manufacturer, Michelin, hence the name of the syndrome. Associated abnormalities vary and may include facial dysmorphism, upslanting palpebral fissures, hypertelorism, cleft palate, genital anomalies, mild developmental delay, ureterocele, smooth muscle hamartoma, nevus lipomatosus, Laron syndrome (dwarfism and high growth hormone and low somatomedin activity), and other defects.\nConcepts: Schizosaccharomyces pombe Proteins (Amino Acid, Peptide, or Protein)\tmichelin tire syndrome (Collagen nevus of skin)\talpha-1-microglobulin-chromophore linkage (protein-chromophore linkage via peptidyl-cysteine)\tAutonomy, Personal (Freedom)\tAdrenal Cortical Carcinoma Clinical TNM Finding v8 (Adrenal Cortical Carcinoma TNM Finding v8)", + "output": "michelin tire syndrome (Collagen nevus of skin)" + }, + { + "input": "Definition: Organ or Tissue Function described as the regulated release of gastric acid induced by the interaction of gastrin with its receptor.\nConcepts: gastrin-induced gastric acid secretion (Organ or Tissue Function)\tTreponema, NOS (Bacterium)\tShort distal phalanx of the 5th finger (Aplasia/Hypoplasia of the distal phalanx of the 5th finger)\tTopical Emulsion Spray Dosage Form (Topical Spray)\tGrade 2 Injury to jugular vein (Finding)", + "output": "gastrin-induced gastric acid secretion (Organ or Tissue Function)" + }, + { + "input": "Definition: envenomation resulting in modulation of process in other organism described as a process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism.\nConcepts: Lanolin Oil (L [Preparations])\tKNOWLEDGE (Finding)\tenvenomation resulting in negative regulation of heart rate of other organism (Biologic Function)\tNCIC (Organization)\tregulation of extrathymic T cell differentiation (regulation of T cell differentiation)", + "output": "envenomation resulting in negative regulation of heart rate of other organism (Biologic Function)" + }, + { + "input": "Definition: Intellectual Product described as study Site specific document containing the determination of the Institutional Review Board (IRB) or Independent Ethics Committee (IEC) that the clinical study with human subject participation has been reviewed and may be conducted at a particular study site within the constraints set forth by the IRB and other institutional and federal requirements.\nConcepts: Withdrawn (Activity)\tIRB/IEC Submission Approval (Intellectual Product)\tregulation of microtubule-based vesicle localization (Cell Function)\tExostosis, CTCAE 5.0 (Finding)\tSuperior sulcus tumor (Pulmonary Sulcus Neoplasm)", + "output": "IRB/IEC Submission Approval (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as any process that modulates the frequency, rate or extent of the regulated release of growth hormone from a cell.\nConcepts: Urethral route (RouteBySite)\tregulation of growth hormone secretion (regulation of peptide hormone secretion)\tBiologic Entity Group Type Code (Intellectual Product)\tenvenomation resulting in regulation of platelet aggregation in other organism (Biologic Function)\tChemokine, CCL27 (Amino Acid, Peptide, or Protein)", + "output": "regulation of growth hormone secretion (regulation of peptide hormone secretion)" + }, + { + "input": "Definition: Antibodies described as a preparation of purified, pasteurized, gamma globulin obtained by the immunization of rabbits with human thymocytes, with T-cell depleting and immunosuppressive activities. Upon administration, rabbit anti-thymocyte globulin (rATG) specifically recognizes, modulates and destroys T-lymphocytes. Although the exact mechanism of action by which rATG causes immunosuppression is not completely understood, it is likely caused by a combination of T-lymphocyte depletion and reduction in T-cell activation and their cytotoxic activities. Administering ATG with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease (GvHD).\nConcepts: N2-(D-1-carboxyethyl)-L-arginine:NAD+ oxidoreductase (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tsteroid hormone biosynthetic process (hormone biosynthetic process)\tIVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy (IVD Panels, Human Genetics, Neuromuscular Disorder)\tAnti-Thymocyte Immune Globulin (Immunosuppressive Agents)\tnormalization asistnce fam (Childrearing Care)", + "output": "Anti-Thymocyte Immune Globulin (Immunosuppressive Agents)" + }, + { + "input": "Definition: something described as the outer membranous connective tissue layer of the heart tissue.\nConcepts: Nucleus of locus caeruleus (Body Part, Organ, or Organ Component)\tepicardium (Serous portion of pericardium)\tMATERIALS, REPAIR OR REPLACEMENT, PACEMAKER (Medical Device)\tCholangiofibrosis (Rat Hyperplasia)\tEntrapped Gray Matter Present (Finding)", + "output": "epicardium (Serous portion of pericardium)" + }, + { + "input": "Definition: Medical Device described as (a) Iontophoresis device intended for certain specified uses: An iontophoresis device is a device that is intended to use a direct current to introduce ions of soluble salts or other drugs into the body and induce sweating for use in the diagnosis of cystic fibrosis or for other uses if the labeling of the drug intended for use with the device bears adequate directions for the device's use with that drug. When used in the diagnosis of cystic fibrosis, the sweat is collected and its composition and weight are determined. (b) Iontophoresis device intended for any other purposes: An iontophoresis device is a device that is intended to use a direct current to introduce ions of soluble salts or other drugs into the body for medical purposes other than those specified in paragraph (a) of this section.\nConcepts: Iontophoresis Units, Sweat Test (Iontophoresis Units)\tfentanyl SL spray (Opioid Receptor Agonist)\tlaryngeal trocars (Trocar)\tCytoreductive Chemotherapy (Therapeutic or Preventive Procedure)\tbrain; atrophy (Central Nervous System)", + "output": "Iontophoresis Units, Sweat Test (Iontophoresis Units)" + }, + { + "input": "Definition: something described as a tumor composed of mature adipocytes and fibrous tissue infiltrating the epineurium and peripheral nerves. It is often seen at birth or during childhood and may be associated with macrodactyly.\nConcepts: Acetobacterium (Eubacteriaceae)\tCannulae, Aspirating (Cannula device)\tchelation heavy metals (Molecular Function)\tALPHA-L-IDURONIDASE (Gene or Genome)\tLipomatosis of Nerve (Lipomatosis, Multiple Symmetrical)", + "output": "Lipomatosis of Nerve (Lipomatosis, Multiple Symmetrical)" + }, + { + "input": "Definition: Pathogenic organism described as the type of pathogen that an animal is verified to be free of.\nConcepts: PATHEX (Qualitative Concept)\tplasmodesmatal desmotubule (Cell Component)\tSkin Clear Cell Basal Cell Carcinoma (Neoplastic Process)\tMedical Day Care (Hospitalization & Institutionalization)\tERBB1 Exon 21 Mutation (Cell or Molecular Dysfunction)", + "output": "PATHEX (Qualitative Concept)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic, solid, fatty alcohol and nonionic surfactant. Cetyl alcohol is used as an emulsifying agent in pharmaceutical preparations.\nConcepts: Manuscript (Manufactured Object)\tprimary miRNA processing (Genetic Function)\tCetyl alcohol (Alcohols)\t57 STOMACH (Upper Gastrointestinal Tract)\tWas Adjuvant Post-Operative Targeted Molecular Therapy Administered (CPTAC Questions)", + "output": "Cetyl alcohol (Alcohols)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: codeine + 2-oxoglutarate + O2 <=> morphine + formaldehyde + succinate + carbon dioxide.\nConcepts: codeine O-demethylase activity (2-oxoglutarate-dependent dioxygenase activity)\tPERSONNEL STAFFING SCHEDULING (Work)\tpartial trisomy 9q non-distal (Disease or Syndrome)\ttrans-synaptic signaling by neuropeptide, modulating synaptic transmission (trans-synaptic signaling by neuropeptide)\tObjects, Astronomic (Astronomical Phenomena)", + "output": "codeine O-demethylase activity (2-oxoglutarate-dependent dioxygenase activity)" + }, + { + "input": "Definition: Detectors, Strain described as detectors designed to sense strain in lenses mounted on eyeglasses. These detectors typically include a polarized light source and two polarized lenses; the amount of light visible in the lens and the pattern of the light show the degree and type of strain in the lenses. Eyeglass lens strain detectors can determine both excessive strain on the lenses and if adequate stress has been placed on the lens to keep it from wobbling or being accidentally dislodged from the frame; the detectors can be used also to verify that the lenses have been appropriately heat-treated for impact resistance.\nConcepts: BiologicEntity.birthCountryCode (Intellectual Product)\tENZYME IMMUNOASSAY, THEOPHYLLINE (Medical Device)\tPolariscopes (Diagnostic, Therapeutic, and Research Equipment)\tUBA Domain (Amino Acid Sequence)\tEWS/FLI 1 Type 1 (Pharmacologic Substance)", + "output": "Polariscopes (Diagnostic, Therapeutic, and Research Equipment)" + }, + { + "input": "Definition: DRRI-2 Questionnaire Question described as deployment Risk & Resilience Inventory-2 - During deployment: I was concerned that I might be taken hostage.\nConcepts: PQL03TC (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycoplasma pneumoniae, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycoplasma Species, DNA)\tcytochrome o ubiquinol oxidase complex location (membrane protein complex)\tRestriction Spectrum Imaging (Diagnostic Procedure)\tDRRI1-G: Concerned Taken Hostage (DRRI-2 Questionnaire Question)", + "output": "DRRI1-G: Concerned Taken Hostage (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Ascending aorta structure described as the portion of the ascending aorta between the aortic annulus and the sinotubular junction.\nConcepts: Beta-Globin c.364G>A (HBB Gene Mutation)\tClinical Complete Response (Finding)\tBulb of ascending aorta (Aorta)\tStage IV Bladder Carcinoma AJCC v7 (Neoplastic Process)\tObese Protein (Endocrine system)", + "output": "Bulb of ascending aorta (Aorta)" + }, + { + "input": "Definition: beta-Lipotropin described as a 90-amino acid peptide derived from post-translational processing of pro-opiomelanocortin (POMC) in the PITUITARY GLAND and the HYPOTHALAMUS. It is the C-terminal fragment of POMC with lipid-mobilizing activities, such as LIPOLYSIS and steroidogenesis. Depending on the species and the tissue sites, beta-LPH may be further processed to yield active peptides including GAMMA-LIPOTROPIN; BETA-MSH; and ENDORPHINS.\nConcepts: (-)-1-(tert-butylamino)-3-[(4-morpholino-1,2,5-thiadiazol-3-yl)oxy]-2-propanol maleate (1:1) (Organic Chemical)\tbeta-lipotropin (Hormones)\tTenotomy (Operation on tendon)\tGastrointestinal Stoma Necrosis (Finding)\tAbsorption, Respiratory Tract (Absorption, Physiological)", + "output": "beta-lipotropin (Hormones)" + }, + { + "input": "Definition: Food Industry described as any aspect of the operations in the preparation, processing, transport, storage, packaging, wrapping, exposure for sale, service, or delivery of food.\nConcepts: Grade 1 Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE (Musculoskeletal and Connective Tissue Disorder - Other, Specify, CTCAE)\tAlexias (Special Education)\tfood handling (Occupational Activity)\tClavulanic Acids (beta-Lactams)\tprotein biotinylation (Molecular Function)", + "output": "food handling (Occupational Activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ATP + a dihydroceramide = ADP + H+ + a dihydroceramide 1-phosphate.\nConcepts: Anaplastic Seminoma (Primary malignant neoplasm)\tdihydroceramide kinase activity (phosphotransferase activity, alcohol group as acceptor)\tEsomeprazole magnesium (Organic Chemical)\tprotein K27-linked deubiquitination (Molecular Function)\tGrade 4 Large intestinal anastomotic leak (Large Intestinal Anastomotic Leak, CTCAE)", + "output": "dihydroceramide kinase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: something described as treatment that adds, blocks, or removes hormones. For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels. To slow or stop the growth of certain cancers (such as prostate and breast cancer), synthetic hormones or other drugs may be given to block the body's natural hormones. Sometimes surgery is needed to remove the gland that makes a certain hormone.\nConcepts: cinnamonum ceylanicum/cinnam (Pharmacologic Substance)\tlambda Phage (Bacteriophages)\ttherapy, endocrine (Pharmacotherapy)\tHistiocytoid Hemangioma of Skin (Benign Neoplasm)\tGlucagon Receptor, human (Amino Acid, Peptide, or Protein)", + "output": "therapy, endocrine (Pharmacotherapy)" + }, + { + "input": "Definition: Refractory Lymphoma described as central nervous system lymphoma that is resistant to treatment.\nConcepts: Bone necrosis (Musculoskeletal necrosis and vascular insufficiency)\tphysical activity (HEALTH-RELATED BEHAVIORS DOMAIN)\tRefractory Primary Central Nervous System Lymphoma (Refractory Lymphoma)\tDecompression, Explosive (Decompression, external)\tLaCrosse Virus (Orthobunyavirus)", + "output": "Refractory Primary Central Nervous System Lymphoma (Refractory Lymphoma)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units.\nConcepts: tetraterpenoid metabolic process (Molecular Function)\tAbnormal circle of Willis morphology (Abnormal cerebral artery morphology)\t2H-Indol-2-one, 3,3-bis(4-(acetyloxy)phenyl)-1,3-dihydro- (Pharmacologic Substance)\tMethotrexate product (Antineoplastic Agents)\tDNA Repair Mutation Positive (Laboratory or Test Result)", + "output": "tetraterpenoid metabolic process (Molecular Function)" + }, + { + "input": "Definition: Temporal Concept described as the time in milliseconds between the application of the excitation pulse and the recording of the peak echo signal.\nConcepts: ECHOTIME (Temporal Concept)\tEEG with generalised slow activity grade 4 (Finding)\tmiR-1243, human (MicroRNAs)\tmicroRNA 107 (Gene or Genome)\tMotoneurons (Multipolar neuron)", + "output": "ECHOTIME (Temporal Concept)" + }, + { + "input": "Definition: something described as a non-metastasizing neoplasm that arises from the frontal sinus.\nConcepts: Cerebellar vermis aplasia (inherited genetic conditions)\tBenign neopl. frontal sinus (Neoplasm of frontal sinus)\tosteopoikilosis (joint and bone dysplasias)\tBiophotonics (Imaging Technology)\th*pg/mL/m2 (Quantitative Concept)", + "output": "Benign neopl. frontal sinus (Neoplasm of frontal sinus)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's overall emotional well-being.\nConcepts: MAD, Mothers Against Decapentaplegic Homolog Interacting Protein, Receptor Activation Anchor Gene (ZFYVE9 gene)\tCecal Diverticulum (Embryonic Structure)\tPrevalences (Vital Statistics)\tOverall Emotional Well-Being (Intellectual Product)\tFactor I Inhibitor Present (Disease or Syndrome)", + "output": "Overall Emotional Well-Being (Intellectual Product)" + }, + { + "input": "Definition: something described as the regulated release of interferon-delta from a cell.\nConcepts: WILDTYPE p53-INDUCED PHOSPHATASE 1 (Gene or Genome)\t-deoxyhypusine synthase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)\tLugano Classification Stage II Bulky Adult Non-Hodgkin Lymphoma AJCC v8 (Neoplastic Process)\tprostaglandin 11-keto reductase (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tinterferon-delta secretion (Cell Function)", + "output": "interferon-delta secretion (Cell Function)" + }, + { + "input": "Definition: Adenocarcinoma described as a tumor formed from the endocrine (argentaffin) cells of the mucosal lining of a variety of organs including the stomach and intestine. These cells are from neuroectodermal origin.\nConcepts: Carcinoid tumour - morphology (Adenocarcinoma)\tHSV-1 IgG Antibody (Laboratory Procedure)\tmntl hlth mgmt (Psychotherapy)\tFunctions of the thoracic respiratory muscles (Respiratory muscle functions)\tarea 15 of Mauss (Body Location or Region)", + "output": "Carcinoid tumour - morphology (Adenocarcinoma)" + }, + { + "input": "Definition: scalpel described as surgical knives designed to cut the anatomical structures of the throat. These devices consist of manual handheld instruments that usually have a sturdy, straight handle and a long, wide blade with a sharp cutting edge at the distal end. Throat surgery knives are used in a variety of surgical procedures; dedicated throat knives intended to cut the tonsils (i.e., tonsillectomy), incision of the larynx (i.e., laryngotomy), and to resect small tumors are also available.\nConcepts: upregulation of peptidyl-tyrosine phosphorylation (Molecular Function)\t(Angina: [crescendo] or [unstable] or [at rest]) or (preinfarction syndrome) or (impending infarction) (Pain and Sensation Related to the Thoracic Organs)\tDeforming Chondrodysplasias, Hereditary (Disorganized development of cartilaginous and fibrous components of the skeleton)\tKnives, Surgical, Throat (Medical Device)\tKFSS101 (KFSS Questionnaire Question)", + "output": "Knives, Surgical, Throat (Medical Device)" + }, + { + "input": "Definition: Finding described as a finding indicating high concentrations of hyaluronic acid in a sample.\nConcepts: Bronchscpy & bronchoalvr lavge (Endoscopic airway clearance)\tcaldesmon (Actin-Binding Protein)\tSymptoms (Symptoms)\tHA-High (Abnormal Blood Chemistry and Hematology Test Result)\tLocal Anesthesia Agents were Administered (CPTAC Responses)", + "output": "HA-High (Abnormal Blood Chemistry and Hematology Test Result)" + }, + { + "input": "Definition: Finding described as the diffusion capacity of the lungs for carbon monoxide adjusted for the ratio of hemoglobin concentration to alveolar volume, and expressed as a proportion of the predicted normal value.\nConcepts: DLCOHVAP (Finding)\tTAURINE (Laboratory Procedure)\tcare life support (Health Care Activity)\tgastroenterostomy (Procedure on small intestine)\tFungal mycelia (Plant Part)", + "output": "DLCOHVAP (Finding)" + }, + { + "input": "Definition: Disease or Syndrome described as syndrome with the association of microtia, eye coloboma and imperforation of the nasolacrimal duct. So far, it has been described in only one family. The phenotype is associated with the presence of five copies of a copy-number-variable region (CNV) located at 4pter. This is the first example of an amplified CNV being associated with a Mendelian disorder. Transmission is autosomal dominant.\nConcepts: AVL01-List A Recall 6 (After B) Word 8 (Intellectual Product)\tAtazanavir Sulfate (atazanavir)\tMeconium Measurement (Chemical procedure)\tBalikova Vermeesch syndrome (Multiple system malformation syndrome)\tBrain Mimicking Fluid (Indicator, Reagent, or Diagnostic Aid)", + "output": "Balikova Vermeesch syndrome (Multiple system malformation syndrome)" + }, + { + "input": "Definition: Medicinal product categorized by structure described as compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds; these compounds often form large macromolecules; for example, plastics, polypeptides, polysaccharides, and nucleic acids.\nConcepts: positive regulation of oocyte development (regulation of oocyte development)\tPolymer-containing product (Chemical categorized by structure)\tMajor Salivary Gland Cancer TNM Finding v7 (Head and Neck Cancer TNM Finding v7)\tPeds-FACIT-F - I Feel Tired (Intellectual Product)\tCeiba Mill. (Bombacoideae)", + "output": "Polymer-containing product (Chemical categorized by structure)" + }, + { + "input": "Definition: Hormone measurement described as the determination of the amount of gonadotropin releasing hormone present in a sample.\nConcepts: Gonadotropin Releasing Hormone (Hormone measurement)\tDelta8-sphingolipid desaturase activity (sphingolipid delta-8 desaturase activity)\tGeneral Transcription Factor IIA (Protein or Riboprotein Complex)\tTask Monitor Scale (Intellectual Product)\tASSOCIATED MOLECULE WITH THE SH3 DOMAIN OF STAM (Metallopeptidase Gene)", + "output": "Gonadotropin Releasing Hormone (Hormone measurement)" + }, + { + "input": "Definition: something described as a surgical lamp (including a fixture) is a device intended to be used to provide visible illumination of the surgical field or the patient.\nConcepts: phosphatase (phosphoric ester hydrolase activity)\t1q25-q31.1 (Chromosome band)\tDrever (Non-Sporting Breed)\tSn - Tin (Metals)\tILLUMINATOR, FIBEROPTIC, SURGICAL FIELD (Medical Device)", + "output": "ILLUMINATOR, FIBEROPTIC, SURGICAL FIELD (Medical Device)" + }, + { + "input": "Definition: Laboratory Procedure described as a laboratory assay to determine the status of the GNAQ gene which encodes guanine nucleotide-binding protein G(q) subunit alpha.\nConcepts: GNAQ Gene Expression Analysis (Biological Assay)\tBenzothiazoles (Organic Chemical)\tall-trans-beta-apo-10'-carotenal cleavage oxygenase activity (Molecular Function)\tKIAA0012 (Toll-Like Receptor Family Gene)\tPoorly Perfused (Finding)", + "output": "GNAQ Gene Expression Analysis (Biological Assay)" + }, + { + "input": "Definition: Neoplastic Process described as a non-metastasizing neoplasm that arises from the tongue.\nConcepts: Skull Postmortem Chisels (Chisels, Postmortem)\tCirculatory Assist Units, Peripheral Compression, Sequential (Medical Device)\t1-[2,3,4-trimethoxybenzyl] piperazine dihydrochloride (Cardiotonic Agents)\tBenign Neoplasm of the Tongue (Benign neoplasm of soft tissues of head)\tIVD Test Reagent/Kits, Hematology, Coagulation Factor XIII, Activated (IVD Test Reagent/Kits, Hematology, Coagulation Factor XIII)", + "output": "Benign Neoplasm of the Tongue (Benign neoplasm of soft tissues of head)" + }, + { + "input": "Definition: hexuronate transmembrane transport described as the process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other.\nConcepts: t(16;21)(q24;q22) (Cell or Molecular Dysfunction)\tpositive regulation of encysted zoospore germination on or near host (Biologic Function)\tPacked Red Cells (Blood product)\tChief Complaint Occurs After Exercise (Finding)\tgalacturonate transmembrane transport (hexuronate transmembrane transport)", + "output": "galacturonate transmembrane transport (hexuronate transmembrane transport)" + }, + { + "input": "Definition: something described as 10-carbon saturated monocarboxylic acids.\nConcepts: inhibin-betaglycan-ActRII complex (plasma membrane protein complex)\tGastrostomy (Therapeutic or Preventive Procedure)\tParaffin-Embedded Specimen (Tissue specimen)\tIMP-2 protein, human (Biologically Active Substance)\tCapric Acids (Fatty Acids)", + "output": "Capric Acids (Fatty Acids)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Rapid Test, Virus, Retrovirus described as serology reagents used in rapid tests to detect antigens or antibodies in a patient's sample to human immunodeficiency viruses of either serotype 1 (HIV-1), serotype 2 (HIV-2), or both. HIV is the cause (etiologic agent) of the acquired immunodeficiency syndrome (AIDS).\nConcepts: Cell Product Encapsulation (Drug Formulation Process)\tCyst of the eyelid (Mass in head or neck)\tmotor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation (Cell Function)\tStage IA Cervical Carcinoma AJCC v8 (Neoplastic Process)\tIVD Test Reagent/Kits, Serology, Rapid Test, Virus, Retrovirus, HIV-1/2 (Medical Device)", + "output": "IVD Test Reagent/Kits, Serology, Rapid Test, Virus, Retrovirus, HIV-1/2 (Medical Device)" + }, + { + "input": "Definition: something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Word recall task word 7 for trial 1, 2, 3.\nConcepts: N-{4-[(3'- [F-18] Fluoroethylphenyl)amino]-6-quinazolinyl}-acrylamide (Radioconjugate)\tUmbrella Protocol (Master Protocol)\tADCRLW07 (Intellectual Product)\tDioxin (Heterocyclic Compounds, 1-Ring)\tMillimeter (Quantitative Concept)", + "output": "ADCRLW07 (Intellectual Product)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of lomustine that may be used in the treatment of anaplastic gliomas and glioblastomas; adult low-grade infiltrative supratentorial astrocytomas (excluding pilocytic astrocytomas) and oligodendrogliomas; and adult intracranial and spinal ependymomas (excluding subependymomas and myxopapillary ependymomas).\nConcepts: Mesothelial tissue (Simple squamous epithelium)\tcell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions (Cell Function)\tLomustine Regimen (Therapeutic or Preventive Procedure)\tN-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide compd. with Lactic Acid (Pharmacologic Substance)\tDiffuse Large B-Cell Lymphoma by Ann Arbor Stage (Diffuse Large B-Cell Lymphoma)", + "output": "Lomustine Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Organic sulfate compound described as the sodium salt of a semisynthetic heparin-like glucosaminoglycan. Although its mechanism of action is unknown, pentosan polysulfate may act as a buffer to control cell permeability by preventing irritating solutes from reaching cells coated with it. Administered orally, excreted pentosan polysulfate adheres to the urinary bladder wall, preventing irritants from entering bladder cells and the development or progression of interstitial cystitis (IC), a complication of some chemotherapies. This agent also exhibits anticoagulant and fibrinolytic properties.\nConcepts: monoglyceridyllipase activity (Molecular Function)\tRNA polymerase III activity (Genetic Function)\tPolysulphate Sodium, Pentosan (Other urologicals in ATC)\tregulation of CD4-positive, alpha beta T cell costimulation (regulation of CD4-positive, alpha-beta T cell activation)\tSalmonella typhi (Salmonella I, group O:9)", + "output": "Polysulphate Sodium, Pentosan (Other urologicals in ATC)" + }, + { + "input": "Definition: something described as regular intercellular matrix\nConcepts: benzyl 2-methyl-3-hydroxybutyrate dehydrogenase activity (Molecular Function)\tSDTM-IECAT (CDISC SDTM Terminology)\tRegular intercellular matrix (Body Substance)\tDEFIC FACTOR II (Coagulation factor deficiency syndrome)\tNeurofeedback (Therapeutic or Preventive Procedure)", + "output": "Regular intercellular matrix (Body Substance)" + }, + { + "input": "Definition: Neoplastic Process described as end-stage hepatocellular carcinoma. Patients will receive symptomatic treatment. (HPB (Oxford) 2005; 7(1):35-41)\nConcepts: Professional Ethics (Ethics)\tBarcelona Clinic Liver Cancer Stage D Hepatocellular Carcinoma (Hepatocellular Carcinoma by BCLC Stage)\tfunctionTypeCode (Intellectual Product)\tcellular response to endotoxin (cellular response to lipid)\tblood samples taking (Specimen Collection, Preparation and Reporting Procedures)", + "output": "Barcelona Clinic Liver Cancer Stage D Hepatocellular Carcinoma (Hepatocellular Carcinoma by BCLC Stage)" + }, + { + "input": "Definition: Technical Aids for the Disabled described as systems designed to amplify a speaker's (e.g., classroom instructor's) voice to facilitate listening by one or more persons in the audience. These devices typically consist of a microphone worn by the speaker that transmits audio signals to individual listening devices. Auditory trainers typically transmit audio signals wirelessly via radio or infrared wireless technology; however, systems using wired connections may also be available. Individual listing devices typically consist of earphones; some systems include wireless receivers that can be coupled to users' hearing aids, using the hearing aid as the listening device. Auditory trainers are typically used to facilitate listening by persons with hearing impairments and/or deficits in maintaining attention or auditory processing.\nConcepts: nutritionist care (Health Care Activity)\tpositive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal (Genetic Function)\tDuffy Fya positivity (Duffy blood group result)\tAuditory Trainers (Technical Aids for the Disabled)\tMIR92A1 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Auditory Trainers (Technical Aids for the Disabled)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of myeloid cells compared to erythroid cells present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: 8Ad (Body Location or Region)\tMyeloid to Erythroid Ratio Measurement (Blood Cell Count Ratio Measurement)\tChoroidal naevus (choroid examination)\tIVD Test Reagent/Kits, Immunoassay, Standard, Fertility Hormone (Medical Device)\tDrug Risk Code (Risk Code)", + "output": "Myeloid to Erythroid Ratio Measurement (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Infection described as disease caused by potent protein neurotoxins produced by Clostridium botulinum, which interfere with the presynaptic release of acetylcholine at the neuromuscular junction; clinical features include abdominal pain, vomiting, acute paralysis, blurred vision and diplopia; botulism may be classified into several subtypes such as food borne, infant, wound, and others.\nConcepts: botulism (Bacterial food poisoning)\tSpinal epidural haemorrhage (Neuraxial hematoma)\tFGFR1 Rearrangement Analysis (molecular diagnostics gene rearrangement)\tSeizure (Nervous System Disorders, CTCAE)\tCrow, NOS (Corvus)", + "output": "botulism (Bacterial food poisoning)" + }, + { + "input": "Definition: Medical Device Attribute described as a description of the sensor used to detect electrical current.\nConcepts: carnitine transporter activity (Molecular Function)\tPressurised container (Manufactured Object)\tsingle-stranded DNA 5'-3' exodeoxyribonuclease activity (5'-3' exodeoxyribonuclease activity)\tSrc Homology 2 Domain Containing Transforming Protein C3 (Amino Acid, Peptide, or Protein)\tType of Electrical Current Sensor (Qualitative Concept)", + "output": "Type of Electrical Current Sensor (Qualitative Concept)" + }, + { + "input": "Definition: Iris and uveal tract infections, irritations and inflammations described as inflammation of the iris, ciliary body, and/or choroid (uveal tract).\nConcepts: Primary Cutaneous Plasmablastic Lymphoma (Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other)\tSIXMW104 (Intellectual Product)\tIn Dwelling Catheters (catheter device)\tCollected (Idea or Concept)\tUVEITIS (Anomaly of eye)", + "output": "UVEITIS (Anomaly of eye)" + }, + { + "input": "Definition: something described as species of APHTHOVIRUS causing upper respiratory tract infection in horses.\nConcepts: Mitochondrial ribonucleic acid (PURINES, PYRIMIDINES AND NUCLEIC ACIDS)\tTAPE, ORTHOPEDIC (Medical Device)\tMASCT-I (Immunologic Factor)\tEquine Rhinovirus type 1 (Virus)\tThermocauterisation (Destructive procedure)", + "output": "Equine Rhinovirus type 1 (Virus)" + }, + { + "input": "Definition: Recombinant Parathyroid Hormone-Related Protein described as a recombinant form of a mature, N-terminal secretory peptide derived from a parathyroid hormone-related protein (PTHrP) preprohormone through posttranslational endoproteolytic processing with vasodilating, myorelaxant, and parathyroid hormone (PTH)-like calciotropic activities. Expressed throughout the cardiovascular system, parathyroid hormone-related protein (1-36) [PTHrP (1-36)] was first identified as the PTH-like hypercalcemic factor of humoral hypercalcemia of malignancy; however, its sequence differs significantly from that of PTH (1-34) although both proteins share the same N-terminal end which accounts for the calciotropic activity. Both PTHrP (1-36) and PTH (1-34) bind to the type 1 parathyroid hormone receptor (PTH1R), a specific seven-transmembrane-helix-containing G protein-coupled receptor mainly located in bone and kidney cells.\nConcepts: Questionnaires (Measurement)\tstage IIB distal bile duct cancer AJCC v7 (Distal Bile Duct Cancer by AJCC v7 Stage)\tPTH-related protein (Recombinant Parathyroid Hormone-Related Protein)\tRNA polymerase III transcription termination (Genetic Function)\tnon-coding RNA export from nucleus (RNA export from nucleus)", + "output": "PTH-related protein (Recombinant Parathyroid Hormone-Related Protein)" + }, + { + "input": "Definition: quinone catabolic process described as the chemical reactions and pathways resulting in the breakdown of endocrocin.\nConcepts: endocrocin breakdown (secondary metabolite catabolic process)\tanti-CD40 agonist monoclonal antibody ABBV-927 (Pharmacologic Substance)\tdiabetes; NIDDM (Diabetes Mellitus)\t/mL/(kg/m2) (Unit of concentration)\tOn the whole, I am satisfied with myself (Clinical or Research Assessment Question)", + "output": "endocrocin breakdown (secondary metabolite catabolic process)" + }, + { + "input": "Definition: Finding described as epileptiform discharges being identified at multiple locations in both hemispheres.\nConcepts: 6p11.2 (Chromosome band)\tELK4 (Gene or Genome)\tBilateral multifocal epileptiform discharges (Multifocal epileptiform discharges)\tmagnetic resonance thermal imaging (Diagnostic Procedure)\tpatient-specific follicular lymphoma-derived anti-idiotype vaccine (Cancer Vaccines)", + "output": "Bilateral multifocal epileptiform discharges (Multifocal epileptiform discharges)" + }, + { + "input": "Definition: IDH2 NP 002159.2:p.R172X described as a change in the amino acid residue at position 172 in the isocitrate dehydrogenase [NADP], mitochondrial protein where arginine has been replaced by tryptophan.\nConcepts: Physicians - Forensic Pathology (Professional or Occupational Group)\tIDH2 p.Arg172Trp (IDH2 NP 002159.2:p.R172X)\tHIGH RESOLUTION MELT ANALYSIS (DNA analysis)\tPATCH, EXTENDED RELEASE (Biomedical or Dental Material)\tSpondylometaphyseal dysplasia with cone-rod dystrophy syndrome (Hereditary disorder of musculoskeletal system)", + "output": "IDH2 p.Arg172Trp (IDH2 NP 002159.2:p.R172X)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Lymphoma Version 4 (FACT-LYM Version 4) Additional Concerns: I have night sweats.\nConcepts: FACT-LYM Version 4 - I Have Night Sweats (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RAB7A (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tRecurrent Gliomatosis Cerebri (Recurrent Childhood Brain Neoplasm)\tgluconate dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tCuyA (Molecular Function)", + "output": "FACT-LYM Version 4 - I Have Night Sweats (Intellectual Product)" + }, + { + "input": "Definition: Memory described as the knowledge or perception that someone or something present has been previously encountered.\nConcepts: Benign nipple neoplasm (Breast and nipple neoplasms benign)\trecognition memory (Mental Process)\tMetachronous Malignant Neoplasm (Malignant Neoplasms)\tvitamin metabolism (Metabolism)\tI kappa B beta protein (Biologically Active Substance)", + "output": "recognition memory (Mental Process)" + }, + { + "input": "Definition: something described as originating in the deserts of northern China and Mongolia and kept in captivity since 1919, these hamsters exhibit a whitish/grey/brown coat color with a black stripe down the spine.\nConcepts: Chinese Hamster (Cricetulus)\tbottle - unit dose (Potency Unit)\tHemorrhagic disease of newborn (Neonatal coagulation disorder)\tElevated C-reactive protein level (Finding)\tRefractory Aggressive Non-Hodgkin Lymphoma (Non-Hodgkin's lymphoma refractory)", + "output": "Chinese Hamster (Cricetulus)" + }, + { + "input": "Definition: intraspecies interaction between organisms described as the aggregation of suspended solids into larger clumps.\nConcepts: intracellularly ATP-gated ion channel activity (intracellular ligand-gated ion channel activity)\tcell-cell adhesion involved in flocculation (Cell Function)\tIntracranial haematoma (Nervous system haemorrhagic disorders)\tlysine transport (basic amino acid transport)\tprimary congenital lymphedema (Growth Factor Receptor Genes)", + "output": "cell-cell adhesion involved in flocculation (Cell Function)" + }, + { + "input": "Definition: Lesion of mucosa described as GASTRITIS with atrophy of the GASTRIC MUCOSA, the GASTRIC PARIETAL CELLS, and the mucosal glands leading to ACHLORHYDRIA. Atrophic gastritis usually progresses from chronic gastritis.\nConcepts: GASTRITIS ATROPHIC (Lesion of mucosa)\trenal tubular disorder with cardiomyopathy syndrome (Hereditary nephropathy)\ttearing (Injury or Poisoning)\tdetection of stimulus involved in G1 DNA damage checkpoint (Cell Function)\tL-arogenate:oxaloacetate aminotransferase activity (Molecular Function)", + "output": "GASTRITIS ATROPHIC (Lesion of mucosa)" + }, + { + "input": "Definition: Quantitative Concept described as minutes times milligrams per milliliter, divided by meters squared.\nConcepts: Parry-Romberg syndrome (Disease or Syndrome)\tmin.mg/ml/m2 (Quantitative Concept)\tmethylglyoxal reductase (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tHuman Immunodeficiency Virus Type I Enhancer Binding Protein 1 wt Allele (Gene or Genome)\tregulation of tetrapyrrole breakdown (Molecular Function)", + "output": "min.mg/ml/m2 (Quantitative Concept)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of light chains that bind to FUSION REGULATORY PROTEIN 1, HEAVY CHAIN to form a heterodimer. They convey functional specificity to the protein.\nConcepts: rhombomere 8 formation (rhombomere formation)\tbenomyl transmembrane transporter activity (amide transmembrane transporter activity)\tRADIOIMMUNOASSAY, PREGNENOLONE (Indicator, Reagent, or Diagnostic Aid)\tv-Ki-ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog c.436G>A (Cell or Molecular Dysfunction)\tFusion Regulatory Protein 1, Light Chains (Immunologic Factor)", + "output": "Fusion Regulatory Protein 1, Light Chains (Immunologic Factor)" + }, + { + "input": "Definition: something described as the part of area p24d located in the upper bank of the cingulate sulcus where the sulcus bounds the most caudal part of the anterior cingulate gyrus in the human. The part in the lower bank of the sulcus is area p24dv. It is not found in the macaque where area p24d is not subdivided ( Vogt-2012 ).\nConcepts: Macrophage count (Blood cell analysis)\tCBDD Structure Terminology (Intellectual Product)\tPFM13 (Transcription factor genes)\tp24dd (Body Location or Region)\tBronchiectasis (Airway structure)", + "output": "p24dd (Body Location or Region)" + }, + { + "input": "Definition: West Germanic Language described as any of the Alemannic dialects spoken in the German-speaking part of Switzerland and in some Alpine communities in Northern Italy bordering Switzerland.\nConcepts: BL11 (CD83 gene)\tIncreased HDL3a concentration (Abnormal HDL3a concentration)\tEGFR Leu861Arg (Cell or Molecular Dysfunction)\tMap Location (UML Entity)\tAlsatian (Language)", + "output": "Alsatian (Language)" + }, + { + "input": "Definition: something described as inhibin beta E chain (350 aa, ~39 kDa) is encoded by the human INHBE gene. This protein plays a role in the secretion of hormones.\nConcepts: 11p13-p12 (Chromosome band)\tINHBE (Amino Acid, Peptide, or Protein)\tprotein localization to pericentric heterochromatin (Genetic Function)\tAdult Rhabdomyosarcoma (Rhabdomyosarcoma)\tGALR2 gene (Gene or Genome)", + "output": "INHBE (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Inflammatory Myofibroblastic Tumor described as accidentally retained SURGICAL SPONGES after surgery.\nConcepts: squalene cyclase activity (Molecular Function)\tRetained Surgical Sponge (Acquired Abnormality)\tHydroxizinum (Piperazine derivative)\tRight ventricular index of myocardial performance (Feature of right ventricle)\tDNA Major Groove Binding Agent (DNA Groove Binding Agent)", + "output": "Retained Surgical Sponge (Acquired Abnormality)" + }, + { + "input": "Definition: something described as developmental psychology research focusing on the infant period.\nConcepts: 4,5-dihydroxypyrene dioxygenase activity (Molecular Function)\tDevelopmental Psychology, Infant (Psychology, Developmental)\tSorbose (Hexoses)\taminosugar (Carbohydrate derivative)\tReceptor, Tyrosine Kinase (Amino Acid, Peptide, or Protein)", + "output": "Developmental Psychology, Infant (Psychology, Developmental)" + }, + { + "input": "Definition: something described as muscarinic acetylcholine receptor M4 (479 aa, ~53 kDa) is encoded by the human CHRM4 gene. This protein is involved in acetylcholine-mediated signaling.\nConcepts: Care Of (General Qualifier)\tregulation of RNA elongation from Pol I promoter (regulation of DNA-templated transcription, elongation)\tSurgical Procedure, Minimal (Operative Surgical Procedures)\tstrategy (general concepts related to thought processes)\tAcetylcholine Receptor, Muscarinic, 4 (G-Protein-Coupled Receptors)", + "output": "Acetylcholine Receptor, Muscarinic, 4 (G-Protein-Coupled Receptors)" + }, + { + "input": "Definition: Finding described as major salivary gland cancer with metastasis in a lymph node larger than 6 cm in greatest dimension and ENE(-).\nConcepts: Major Salivary Gland Cancer cN3a TNM Finding v8 (Major Salivary Gland Cancer cN3 TNM Finding v8)\tC-Form DNA (Nucleic Acid, Nucleoside, or Nucleotide)\tMMS1-What is 100 Take Away 7 (Intellectual Product)\tMonitors, Environmental, Air Humidity/Temperature (Monitors, Environmental)\tprincipal insular short gyri (Body Part, Organ, or Organ Component)", + "output": "Major Salivary Gland Cancer cN3a TNM Finding v8 (Major Salivary Gland Cancer cN3 TNM Finding v8)" + }, + { + "input": "Definition: Electrocardiogram finding described as an electrocardiographic recording that does not demonstrate any significant signs of ischemia or conduction abnormalities.\nConcepts: Neonatal Epileptic Seizure (Finding)\t(3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diol Diacetate (Combined Oral Contraceptives)\tmesenchymal cell proliferation involved in lung development (Cell Function)\tINSIGNIFICANT DISEASE (Electrocardiogram finding)\tUlnar diaphysis (Bone structure of shaft of ulna)", + "output": "INSIGNIFICANT DISEASE (Electrocardiogram finding)" + }, + { + "input": "Definition: something described as obstruction of the bowel by an advanced malignant tumor. It is a complication especially in patients with an advanced abdominal malignant tumor.\nConcepts: mesothelial-mesenchymal cell signaling involved in early lung development (Cell Function)\tMalignant Bowel Obstruction (Anatomical Abnormality)\tcitrulline--aspartate ligase activity (ligase activity, forming carbon-nitrogen bonds)\tDuration of Participation (Duration)\tGUM (Micronesia)", + "output": "Malignant Bowel Obstruction (Anatomical Abnormality)" + }, + { + "input": "Definition: Organic Chemical described as a proprietary plasmid DNA expression vector encoding bi-functional short hairpin RNAs (bi-shRNAs) targeting the identical type 1 translocation junction region of the human fusion oncogene Ewing sarcoma (EWS)/Ets family transcription factor Friend leukemia virus integration 1 (FLI1) and are encapsulated in liposomal delivery vehicle (lipoplex; LPX), with potential antineoplastic activity. pbi-shRNA EWS/FLI1 type 1 contains 2 stem-loop structures encoded by a plasmid vector: one cleavage-dependent unit with perfectly matched passenger- and guide-strand, which is the small interfering RNA (siRNA)-like component, and one cleavage-independent unit composed of a strategically mismatched double strand, which is the microRNA (miRNA)-like component. Upon intratumoral administration and transcription into tumor cells, one shRNA unit with an imperfectly matched sequence causes inhibition of EWS/FLI1 messenger RNA (mRNA) translation (through mRNA sequestration and cleavage-independent degradation) while the other unit with a perfectly matched sequence promotes EWS/FLI1 mRNA degradation (through cleavage-dependent mRNA silencing). This prevents EWS/FLI1 expression in tumor cells, which results in a reduction of tumor cell proliferation. The EWS/FLI1 type 1 fusion gene product is overexpressed in type 1 Ewing's sarcoma and correlates with increased tumor proliferation and poor prognosis.\nConcepts: Dynamic motion X-ray spinal one region each report (Computer-enhanced radiology)\tBifunctional Expression Vector Plasmid DNA-bi-shRNA EWS/FLI1 Type 1 Lipoplex (Antineoplastic Biological Agent)\tPUL0225 (Intellectual Product)\tchromatin lock complex (chromatin silencing complex)\tstarch microspheres (A [Preparations])", + "output": "Bifunctional Expression Vector Plasmid DNA-bi-shRNA EWS/FLI1 Type 1 Lipoplex (Antineoplastic Biological Agent)" + }, + { + "input": "Definition: carboxylic ester hydrolase activity described as catalysis of the reaction: 2 H2O + a phosphatidylcholine = sn-glycero-3-phosphocholine + 2 H+ + 2 a carboxylate.\nConcepts: N-(indole-3-acetyl)-L-lysine synthetase activity (Molecular Function)\tTestwiseness (Educational Testing & Counseling)\tCreatine kinase isoenzyme, CK1 fraction (Clinically relevant isoenzyme)\tFAC00513 (Intellectual Product)\tphosphatidyl phospholipase B activity (carboxylic ester hydrolase activity)", + "output": "phosphatidyl phospholipase B activity (carboxylic ester hydrolase activity)" + }, + { + "input": "Definition: Retinoids described as an orally available, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.\nConcepts: Neoplasms, Sweat Gland (Sweat Gland Diseases)\tRal GTPase binding (Molecular Function)\tCentral lymph (Body Substance)\tPERETINOIN (Retinoids)\tCetuximab-IRDye800 (Immunoconjugates)", + "output": "PERETINOIN (Retinoids)" + }, + { + "input": "Definition: Finding described as nasopharyngeal cancer with distant metastasis.\nConcepts: LOOH (Peroxides)\tNasopharyngeal Cancer pM1 TNM Finding v8 (Nasopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8)\tSwi5-Sfr1 complex (Cell Component)\tDecreased serum complement C9 (Finding)\tAnti-HLA-DR Monoclonal Antibody IMMU-114 (Monoclonal Antibodies)", + "output": "Nasopharyngeal Cancer pM1 TNM Finding v8 (Nasopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in activation of Sp1 transcription. It is also involved in vitamin D and thyroid hormone binding.\nConcepts: Nanotechnologies (Technology)\ttongue muscle cell differentiation (skeletal muscle fiber differentiation)\tCliniMACS CD34 Reagent System (Immunological Flow Cytometry)\tCRSP, 150-KD SUBUNIT (Sp1 Activation Cofactor Gene)\tHelicase MOI Glu1813Asp (DICER1 Protein Variant)", + "output": "CRSP, 150-KD SUBUNIT (Sp1 Activation Cofactor Gene)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of chanoclavine-I aldehyde biosynthetic process.\nConcepts: Spleen, Enlarged (Spleen)\tADL03-Highest Telephone Use Performance (Intellectual Product)\tcandicidin metabolic process (antibiotic metabolic process)\tregulation of chanoclavine-I aldehyde formation (Molecular Function)\tbehavior infants (Child Behavior)", + "output": "regulation of chanoclavine-I aldehyde formation (Molecular Function)" + }, + { + "input": "Definition: something described as having to do with the esophagus, the muscular tube through which food passes from the throat to the stomach.\nConcepts: Polyomavirus maccacae (Polyomavirus)\tpenis hypospadias penoscrotal (Posterior hypospadias)\tJUN phosphorylation (Protein phosphorylation)\tWNK lysine deficient protein kinase 1 (Gene or Genome)\toesophageal (Anatomy Qualifier)", + "output": "oesophageal (Anatomy Qualifier)" + }, + { + "input": "Definition: Completion Status described as a term used to describe the state or condition of the completeness of the procedure agent administration data.\nConcepts: Hemochromatosis Gene Deletion/Duplication Panel Reagents (Medical Device)\tGAD0109 (Intellectual Product)\tMicrobial IC95 Fold Change from Baseline (Laboratory or Test Result)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, LAMA2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tAGSTAT (Qualitative Concept)", + "output": "AGSTAT (Qualitative Concept)" + }, + { + "input": "Definition: Interictal epileptiform activity described as EEG discharges recorded in particular areas of a localized (focal) abnormality in cerebral electrical activity recorded along the scalp by electroencephalography (EEG).\nConcepts: POROUS POLYETHYLENE OSSICULAR REPLACEMENT (Medical Device)\tDiarrheal illness within last 2 wks, hx (Gastrointestinal tract finding)\tCalcium Urine Excretion Rate (Quantitative Concept)\tPHQ Screener Version - Thoughts Be Better Off Dead (Intellectual Product)\tEEG with focal epileptiform discharges (Finding)", + "output": "EEG with focal epileptiform discharges (Finding)" + }, + { + "input": "Definition: Retinoblastoma Clinical TNM Finding v8 described as a clinical finding about one or more characteristics of retinoblastoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.\nConcepts: Linear Accelerator Radiosurgical Image-Guided Stereotactic Systems (Medical Device)\tGrade 1 Enterovesical fistula (Enterovesical Fistula, CTCAE)\tNeoplasm of major salivary gland (Mouth Neoplasms)\tprotein propionyltransferase activity (N-acyltransferase activity)\tRetinoblastoma Clinical Regional Lymph Nodes TNM Finding v8 (Finding)", + "output": "Retinoblastoma Clinical Regional Lymph Nodes TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Contracture of joint of thumb described as chronic loss of joint motion of the carpometacarpal joint of the thumb due to structural changes in non-bony tissue. This joint is formed by the first metacarpal and the trapezial bone and is also called Articulatio carpometacarpalis pollicis, carpometacarpal articulation of thumb, carpometacarpal joint of thumb or first carpometacarpal articulation. Seldom referred to as thumb saddle joint.\nConcepts: Contractures of the carpometacarpal joint of the thumb (Anatomical Abnormality)\tPQL1403 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)\tStage IV Adult Diffuse Mixed Cell Lymphoma (Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma)\t'de novo' protein folding (Molecular Function)\tCDISC SEND Death Diagnosis Object of Measurement Terminology (Unused Subset Concept)", + "output": "Contractures of the carpometacarpal joint of the thumb (Anatomical Abnormality)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of ERBB3 signaling pathway.\nConcepts: posttranslational protein amino acid acetylation (Post-Translational Protein Processing)\tantipodal cell degeneration (Cell Function)\tParental Refusal for Current Questionnaire (Finding)\tdown regulation of ERBB3 signaling pathway (Cell Function)\tnegative regulation of endocardial cushion to mesenchymal transition involved in valve formation (regulation of endocardial cushion to mesenchymal transition involved in heart valve formation)", + "output": "down regulation of ERBB3 signaling pathway (Cell Function)" + }, + { + "input": "Definition: something described as level 2a Fetal Growth Restriction is defined by two criteria: first, Level 2 evidence of pregnancy dating; second, at least one of the following requirements must be met: a) Estimated fetal weight below the third percentile using locally-accepted growth curve; OR b) Estimated fetal weight below the tenth percentile using locally-accepted growth curve AND either findings of absent or reversed end-diastolic flow of the umbilical artery Doppler OR a finding of oligohydramnios.\nConcepts: Trophoblastic Neoplasm, Gestational (Primary malignant neoplasm of female genital organ)\tBroad phalanges of the 4th finger (Broad phalanges of the hand)\tCampylobacter jejuni infection (Disease or Syndrome)\tGrade 4 Nervous system disorders - Other, specify (Finding)\tGAIA Level 2a Fetal Growth Restriction (Intellectual Product)", + "output": "GAIA Level 2a Fetal Growth Restriction (Intellectual Product)" + }, + { + "input": "Definition: cytosine transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in).\nConcepts: Female Genital (Pelvic segment of trunk)\tKLOECKERA JAPONICA (Kloeckera)\tCPACSs (Picture Archiving and Communication Systems)\tSebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid, pigmented nevus syndrome (Congenital hamartoma of skin)\tcytosine:hydrogen ion symporter activity (solute:proton symporter activity)", + "output": "cytosine:hydrogen ion symporter activity (solute:proton symporter activity)" + }, + { + "input": "Definition: Juvenile astrocytoma described as the reemergence of a childhood astrocytic tumor after a period of remission.\nConcepts: Right Atrial Isomerism with Asplenia (Congenital anomaly of spleen)\tRecurrent Astrocytic Tumor (Recurrent Childhood Central Nervous System Neoplasm)\tNeuromodulations, Percutaneous Electrical (Therapeutic or Preventive Procedure)\tStage IIB Small Intestinal Adenocarcinoma (Neoplastic Process)\tHedeoma (Mentheae)", + "output": "Recurrent Astrocytic Tumor (Recurrent Childhood Central Nervous System Neoplasm)" + }, + { + "input": "Definition: Medical Device described as ophthalmic measuring instruments designed for the automated detection and measurement of refractive errors by projecting light into the examinee's eye through the pupil and assessing its reflection. These instruments are typically handheld devices with a light source, a lens, and a mirror that throw either a streak or a spot of light through the pupil of the patient. The examiner moves the instrument and observes the movement of the shadow of the reflected light in the eye in the same or the opposite direction of the device; a set of trial lenses is used to neutralize the reflex. The optical power of the lenses and other data (e.g., the distance between the instrument and the examinee) are used to calculate the refractive errors. Retinoscopes are used mainly for lens fitting and for refractive surgery assessments.\nConcepts: apocynum cannabinum/indian h (Homeopathic remedies letter A)\tEsophagus and Esophagogastric Junction Cancer (Squamous Cell Carcinoma and Adenocarcinoma) pT1 TNM Finding v8 (Finding)\tRetinoscopes (Ophthalmoscopes)\tIRB-IEC Report (Intellectual Product)\tSOLUTION, HELLY (Indicator, Reagent, or Diagnostic Aid)", + "output": "Retinoscopes (Ophthalmoscopes)" + }, + { + "input": "Definition: Free upper limb region described as free upper limb region which includes the hand and wrist.\nConcepts: Chirocarpal region (Body Location or Region)\tCrotoxin (Vaccine Adjuvant)\tNeopterin Measurement (Measurement of substance)\tsulfate:bicarbonate antiporter activity (secondary active sulfate transmembrane transporter activity)\tNectins (Amino Acid, Peptide, or Protein)", + "output": "Chirocarpal region (Body Location or Region)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 6-hydroxy-3-succinoylpyridine + H2O = succinic semialdehyde + 2,5-dihydroxypyridine.\nConcepts: Diphosphonate (Calcium regulating agent)\tacyl-CoA:1-alkenylglycerophosphoethanolamine O-acyltransferase activity (O-acyltransferase activity)\tIVD Panels, Human Genetics, Hearing Loss, Comprehensive, Del/Dup (Medical Device)\t6-hydroxy-3-succinoylpyridine hydrolase activity (Molecular Function)\tnotochord cell vacuolation (vacuole organization)", + "output": "6-hydroxy-3-succinoylpyridine hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Antigens described as an antigen preparation derived from Bacillus Calmette-Guerin, used as a component of BCG vaccine.\nConcepts: Bacillus Calmette-Guerin Antigen (Antigens, Bacterial)\tchildhood gemistocytic astrocytoma (Childhood Astrocytoma)\tRecombinant Soluble Human CD4 Protein (Immunologic Factor)\t8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one, 2,3,9,10,11,12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)- (Protein Kinase Inhibitors)\tNidogen-1 C-Terminal Domain (Amino Acid, Peptide, or Protein)", + "output": "Bacillus Calmette-Guerin Antigen (Antigens, Bacterial)" + }, + { + "input": "Definition: Immunologic Factor described as a bicyclam with hematopoietic stem cell-mobilizing activity. Plerixafor blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation.\nConcepts: Onset of Angina Pectoris Event (Finding)\tPlerixafor-containing product (Immunologic Adjuvants)\tFibroblast Growth Factor Receptor 4 Alteration Positive (Laboratory or Test Result)\tSarcoma FNCLCC Grade 1 (Neoplastic Process)\tCream plus Soft Vaginal Capsule Dosage Form (Biomedical or Dental Material)", + "output": "Plerixafor-containing product (Immunologic Adjuvants)" + }, + { + "input": "Definition: something described as the determination of the ratio of neutrophils compared to lymphocytes present in a biological sample. The measurement may be expressed as a ratio or percentage.\nConcepts: transacylation (Phenomenon or Process)\tUnit of magnetic flux (Unit)\tMORGANELLA MORGANII, ORNITHINE-NEGATIVE (Morganella morganii)\tpositive regulation of hepatic stellate cell contraction (positive regulation of actin filament-based movement)\tNeutrophil to Lymphocyte Ratio Measurement (Laboratory Procedure)", + "output": "Neutrophil to Lymphocyte Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: 1st Generation/Typical described as organic heterocyclic compound used as a tranquilizing agent.\nConcepts: Loxapina (L [Preparations])\tlipoprotein localization to membrane (Cell Function)\tM\u00e9tolazone (Saluretic agent)\tmembrane protein proteolysis (Molecular Function)\tFocal aware sensory seizure with gustatory features (Disease or Syndrome)", + "output": "Loxapina (L [Preparations])" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the fibrous connective tissue surrounding the root of a tooth that separates it from and attaches it to the alveolar bone.\nConcepts: 16S rRNA (guanine(1207)-N(2))-methyltransferase activity (rRNA (guanine-N2-)-methyltransferase activity)\tfemale gonad development (Organ or Tissue Function)\tpositive regulation of clathrin cage assembly (regulation of clathrin coat assembly)\tPapule, NOS (skin lesion morphology)\tLigament, Periodontal (Odontogenic Tissue)", + "output": "Ligament, Periodontal (Odontogenic Tissue)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate.\nConcepts: down-regulation of synaptic growth at neuromuscular junction (regulation of synaptic growth at neuromuscular junction)\tInfection, Gnathostoma (Disease or Syndrome)\tUDP-glucose 6-dehydrogenase activity (Molecular Function)\tCSF protein decreased (Cerebrospinal fluid tests)\tChuukese race (Population Group)", + "output": "UDP-glucose 6-dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a portion of the retinal rod cell largely consisting of a stack of discs (membrane infoldings that are incompletely separated in cones) that are continually replenished near the inner segment and that are shed from the distal end and phagocytosed by the pigmented epithelium.\nConcepts: Shampoo Caps (Patient Caps)\tOuter segment of rod cell (Other Anatomic Concept)\tBPRS-A - Mannerisms and Posturing (BPRS-A Clinical Classification Question)\tangioedema (Skin and subcutaneous tissue disorders)\tdetermination of left/right asymmetry (Organism Function)", + "output": "Outer segment of rod cell (Other Anatomic Concept)" + }, + { + "input": "Definition: Professional Organization or Group described as an organization that provides healthcare services or that is involved in the provision of health care activities. Groupings or subdivisions of an organization, such as departments, may also be considered as organizations where there is a need to identify them.\nConcepts: anal fin morphogenesis (Organism Function)\tProtector Device (Medical Device)\tModular Medical Facilities, Stationary, Emergency Care (Medical Device)\tWaldenstrom's macroglobulinemia recurrent (Lymphoplasmacytoid lymphoma/immunocytoma recurrent)\tHCO (Professional Organization or Group)", + "output": "HCO (Professional Organization or Group)" + }, + { + "input": "Definition: Retinal Hemorrhage described as a type of intraretinal hemorrhage that is located in the superficial retina between the inner limiting membrane and the retinal nerve fiber layer.\nConcepts: Typhlitis, CTCAE 5.0 (Finding)\tCDC37 Gene (Gene or Genome)\tgrasping reflex (Organism Function)\tSub-inner limiting membrane hemorrhage (Disease or Syndrome)\tDDSTRESC (Character Result or Finding in Standard Format)", + "output": "Sub-inner limiting membrane hemorrhage (Disease or Syndrome)" + }, + { + "input": "Definition: Cell Function described as the series of events in which information about cell size is received and converted into a molecular signal, contributing to a G2/M transition size control checkpoint.\nConcepts: Conductive Layer Patient Warming Units, Infant (Warming Units, Patient, Conductive Layer)\tWHODAS 2.0 - 12-ITEM PROXY (Intellectual Product)\tAceticum acidum, glacial acetic acid, Homeopathic preparation (Organic Chemical)\tdetection of stimulus involved in G2 cell size control checkpoint (Cell Function)\tcell wall macromolecule catabolic process involved in cytogamy (Cell Function)", + "output": "detection of stimulus involved in G2 cell size control checkpoint (Cell Function)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 5q\nConcepts: Parainfluenza virus 2 (Virus)\tTrochanter, Lesser (Bone structure of lower limb)\tcellular response to basic pH (Cell Function)\t5q34-q35 (Cell Component)\tIncrease in glutamine content of the diet compared to the assessed baseline intake of glutamine for the individual. (Therapeutic or Preventive Procedure)", + "output": "5q34-q35 (Cell Component)" + }, + { + "input": "Definition: Deleterious Mutation described as a change in the nucleotide sequence of the HDAC2 gene that is associated with increased risk of disease.\nConcepts: Musculus thoracicus (Chest wall structure)\tDeleterious RPD3 Gene Mutation (Cell or Molecular Dysfunction)\tanti-GM2 monoclonal antibody BIW-8962 (Monoclonal Antibodies)\tDRRI1M10 (DRRI-2 Questionnaire Question)\tanalysis dna (Genetic investigation procedure)", + "output": "Deleterious RPD3 Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Dermatomyositis described as a muscle disease that causes inflammation and a skin rash\nConcepts: TARC protein, human (Amino Acid, Peptide, or Protein)\tLichens (Lower plant)\tinsulin receptor complex location (Cell Component)\tDiffuse Large B-Cell Lymphoma Refractory (Neoplastic Process)\tDermatomyositis, adult type (Dermatomyositis)", + "output": "Dermatomyositis, adult type (Dermatomyositis)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in membrane-targeting of protein kinase A.\nConcepts: SAQUINAVIR (Antiviral Agents)\tEGFRVP (Protein or Enzyme Type Measurement)\tProducts and technology used for play (Products and technology for personal use in daily living)\tsulphafurazole (Organic Chemical)\tNEUROBEACHIN (Adaptor Signaling Protein Gene)", + "output": "NEUROBEACHIN (Adaptor Signaling Protein Gene)" + }, + { + "input": "Definition: hydroxyaminoacid described as alpha-amino beta-hydroxy butyric acid, a natural amino acid essential for optimal growth in infants and for nitrogen equilibrium in adults.\nConcepts: Golgi cell precursor proliferation (cell proliferation in hindbrain ventricular zone)\tGrade 3 Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(ANC <1.0 x 10e9/L, fever >=38.5 degrees C) (Febrile Neutropenia without Clinically or Microbiologically Documented Infection with Absolute Neutrophil Count Less Than 1 X 10e9 per Liter and Temperature Greater Than or Equal to 38 Point 5 Degrees Celsius, CTCAE)\tbone marrow; disease (Lymphatic Diseases)\tl-threonine (Biologically Active Substance)\tAge appropriate discipline education group each 60 minutes (Parenting education and/or skills training)", + "output": "l-threonine (Biologically Active Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as any substance that inhibits dihydropyrimidine dehydrogenase, a rate limiting enzyme in the degradation of pyrimidines. Inhibition of dihydropyrimidine dehydrogenase increases the biological half-life and efficacy of 5-Fluorouracil (5-FU).\nConcepts: limb movement (Movement)\tNADP Inhibitors (Enzyme Inhibitor Drugs)\tCitrate Excretion Rate (Laboratory Procedure)\tGrade 3 Blood Antidiuretic Hormone Abnormal, CTCAE (Finding)\tHigh Hemoglobin Level (Elevated Test Result)", + "output": "NADP Inhibitors (Enzyme Inhibitor Drugs)" + }, + { + "input": "Definition: Disease or Syndrome described as infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.\nConcepts: Creatinine Clearance Formula (Quantitative Concept)\tinner ear development (Organ or Tissue Function)\tGrade 1 Esophageal hemorrhage (Finding)\tDisease caused by Respirovirus (Disease due to Paramyxovirinae)\tnecroptotic signalling pathway (Cell Function)", + "output": "Disease caused by Respirovirus (Disease due to Paramyxovirinae)" + }, + { + "input": "Definition: Cell Component described as a protein complex that consists of an alpha4-beta1 integrin complex bound to thrombospondin-2.\nConcepts: dakota north (Region of United States of America)\tScanning Proton Beam Therapy (Proton Therapy)\tEpithelioid Angioendothelioma of the Lung (Neoplasm of uncertain behavior of respiratory tract)\talpha4-beta1 integrin-thrombospondin-2 complex (plasma membrane protein complex)\tABUTMENT, IMPLANT, DENTAL, ENDOSSEOUS (Medical Device)", + "output": "alpha4-beta1 integrin-thrombospondin-2 complex (plasma membrane protein complex)" + }, + { + "input": "Definition: something described as moderate symptoms; limiting instrumental ADL\nConcepts: PODCI310 (PODCI Adolescent Self-Reported Version Questionnaire Question)\tGrade 2 Trigeminal nerve disorder (Trigeminal Nerve Disorder, CTCAE)\tNew Component of BRCAA1 A Complex Gene (BABAM1 gene)\tPromyeloblasts (Laboratory Procedure)\tPseudohypoaldosteronism Type Is (Pseudohypoaldosteronism)", + "output": "Grade 2 Trigeminal nerve disorder (Trigeminal Nerve Disorder, CTCAE)" + }, + { + "input": "Definition: something described as a multisubunit protein complex that plays a central role in chromosome condensation.\nConcepts: condensin complex (Cell Component)\tCPS0103 (Intellectual Product)\tMitochondrial Uncoupling Protein 2 Hyperinsulinism (Disease or Syndrome)\tNumerical Chromosome Aberration (Chromosome Aberrations)\toropharynx cancer, stage II (Stage II Pharynx Carcinoma)", + "output": "condensin complex (Cell Component)" + }, + { + "input": "Definition: Qualitative Concept described as a substance that is produced by a living organism and is toxic, noxious, or poisonous.\nConcepts: Cluster (Quantitative Concept)\tInoculating-loop steriliser (Electrical sterilization device)\tToxin (Qualitative Concept)\t/dL (Unit of Dose Calculation)\tRNA Polymerase II Transcriptional Regulation Mediator (Amino Acid, Peptide, or Protein)", + "output": "Toxin (Qualitative Concept)" + }, + { + "input": "Definition: Abnormal insulin like growth factor binding protein acid labile subunit level described as blood concentration of insulin like growth factor binding protein acid labile subunit level below normal limits. []\nConcepts: Sex Roles (Social Behavior)\tRectal cancer (Malignant Rectal Neoplasm)\tDecreased levels of acid labile subunit (Abnormal insulin like growth factor binding protein acid labile subunit level)\tSmall Intestine Cancer pTX TNM Finding v7 (Small Intestine Cancer Pathologic Primary Tumor TNM Finding v7)\tHUMPI (Molecular Function)", + "output": "Decreased levels of acid labile subunit (Abnormal insulin like growth factor binding protein acid labile subunit level)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the estrogen hormone in a biological specimen.\nConcepts: Chitin (Organic Chemical)\tTracheal syrinx (Body Part, Organ, or Organ Component)\tOestrogen measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tADL01-Pastime: Musical Instrument (ADCS-ADL Questionnaire Question)\tBiological Product (Biologically Active Substance)", + "output": "Oestrogen measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: Finding described as soft tissue sarcoma of the retroperitoneum measuring more than 15 cm in greatest dimension.\nConcepts: EC 3.6.4.- (Enzyme)\tAdenosquamous Colon Carcinoma (Colon Carcinoma)\tSoft Tissue Sarcoma of the Retroperitoneum pT4 TNM Finding v8 (Soft Tissue Sarcoma of the Retroperitoneum Pathologic Primary Tumor TNM Finding v8)\tHomology Domain, src (Protein Interaction Domains and Motifs)\tUHDR112D (Intellectual Product)", + "output": "Soft Tissue Sarcoma of the Retroperitoneum pT4 TNM Finding v8 (Soft Tissue Sarcoma of the Retroperitoneum Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: something described as a form of ventricular pre-excitation characterized by a normal PR interval and a long QRS interval with an initial slow deflection (delta wave). In this syndrome, the atrial impulse travel to the ventricle via the MAHAIM FIBERS which connect ATRIOVENTRICULAR NODE directly to the right ventricle wall (NODOVENTRICULAR ACCESSORY PATHWAY) or to the RIGHT BUNDLE BRANCH OF HIS (nodofascicular accessory pathway).\nConcepts: Study Subject Registration Center (Central)\tPreexcitation, Mahaim-Type (Preexcitation Syndrome)\tColorectal DLBCL (Diffuse Large B-Cell Lymphoma)\tglobulin serum (Blood Proteins)\tFOSI - Worry My Condition Will Get Worse (Intellectual Product)", + "output": "Preexcitation, Mahaim-Type (Preexcitation Syndrome)" + }, + { + "input": "Definition: Immunologic Factor described as an immunoconjugate consisting of anti-carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) conjugated to a cytotoxic agent, with potential antineoplastic activity. Upon administration of anti-CEACAM5 antibody-drug conjugate SAR408701, the antibody moiety targets CEACAM5 on tumor cells. Upon antibody/antigen binding and internalization, the immunoconjugate releases the cytotoxic agent, which results in tumor cell death. CEACAM5, a member of the CEA family of proteins that plays a key role in cell migration, cell invasion, and cell adhesion, is overexpressed by a variety of cancer cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C117229\" active clinical trials using this agent.\nConcepts: eIF2 Regulation Pathway (Molecular Function)\tNutritional Hypophosphatemic Rickets (Nutritional Rickets)\tarea 6 of Vogts (Neuronames Brain Hierarchy)\tLipooxygenase Inhibitor (Enzyme Inhibitor Drugs)\tAnti-CEACAM5 Antibody-Drug Conjugate SAR408701 (Immunologic Factor)", + "output": "Anti-CEACAM5 Antibody-Drug Conjugate SAR408701 (Immunologic Factor)" + }, + { + "input": "Definition: Additional values described as something that happens at a given place and time.\nConcepts: Foramen Primum (Other Embryologic Structure)\tRecruitment Period (Clinical Trial Period)\tevent (SNOMED CT Concept)\tFTA(Abs) - Fluorescent treponemal antibody test (Immunologic identification of antigen or antibody)\tOWBR (Quantitative Concept)", + "output": "event (SNOMED CT Concept)" + }, + { + "input": "Definition: Galactitol described as a bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C425\" active clinical trials using this agent.\nConcepts: Fermenter/Bioreactors, Microbiology (Fermenter/Bioreactors)\tNeedle guide, device (Guide device)\tDulcitol diepoxide (Epoxide Compound)\t3: 3127031-3086421 (Chromosome 3 Physical Location)\tPhysical Examination Original Result (Quantitative Concept)", + "output": "Dulcitol diepoxide (Epoxide Compound)" + }, + { + "input": "Definition: Humanistic psychotherapy described as a procedure in which the therapist refrains from directing the client, with unconditional positive regard for the client, and communication of accurate empathy.\nConcepts: Nondirective Therapies (Psychotherapy)\tANTIGEN, CF, (INCLUDING CF CONTROL), RUBEOLA (Indicator, Reagent, or Diagnostic Aid)\tCDR - Home and Hobbies (Intellectual Product)\tPedsQL Neuromuscular Module Version 3.0 Young Child Report - Get Hurt Accidentally (PedsQL Neuromuscular Module Version 3.0 Young Child Report Questionnaire Question)\tDR3 and DR4/5 Mediated Apoptosis Pathway (Apoptosis Regulation Pathway)", + "output": "Nondirective Therapies (Psychotherapy)" + }, + { + "input": "Definition: Score described as the numerical value that represents the result of a clinical assessment of muscle strength and function during flexion that is based on the Medical Research Council Manual Muscle. (Medical Research Council. Aids to examination of the peripheral nervous system. Memorandum no. 45, superseding War Memorandum No. 7. London: Her Majesty's Stationary Office; 1976. doi:10.1016/0022-510X(77)90205-2).\nConcepts: MMTFLX (Score)\tPHAGES, STAPHYLOCOCCAL TYPING, ALL TYPES (Indicator, Reagent, or Diagnostic Aid)\tE/A dx Trkofytn tst bloc ea. (Laboratory Procedure)\tGastric hyperplastic polyp (Polyp of stomach and duodenum)\tFormaldehyde Vapor Disinfectors, Enclosure (Disinfectors)", + "output": "MMTFLX (Score)" + }, + { + "input": "Definition: Mirror described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: MIRROR, GENERAL & PLASTIC SURGERY (Mirror)\tEPIC109 (EPIC-26 Questionnaire Question)\tHibernation, function (dormancy process)\tHAQ-DI Without VAS - Dress Yourself (HAQ-DI Without VAS Questionnaire Question)\tregulation of heterotypic cell-cell adhesion (regulation of cell-cell adhesion)", + "output": "MIRROR, GENERAL & PLASTIC SURGERY (Mirror)" + }, + { + "input": "Definition: something described as a self-report measure of perceived ability to perform various mathematical tasks and preference for the use of numerical versus prose information. The 8-item scale contains no mathematics questions and has no correct or incorrect answers. Instead, it consists of 4 questions asking respondents to assess their numerical ability in different contexts and 4 questions asking them to state their preferences for the presentation of numerical and probabilistic information.\nConcepts: FAC057-I Am Able to Enjoy Life (Intellectual Product)\tSubjective Numeracy Scale (Clinical or Research Assessment Questionnaire)\tEMO1-Number Stimuli Portraying Neutral (Intellectual Product)\tAscending part of duodenum (Duodenum)\tSodium/Phosphate Cotransporter 2B (Biologically Active Substance)", + "output": "Subjective Numeracy Scale (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as a 128 bit identifier. Depending on the mechanism used to generate it, it is either guaranteed to be different from all other UUIDs/GUIDs generated until 3400 AD or extremely likely to be different. Its relatively small size lends itself well to sorting, ordering, and hashing of all sorts, storing in databases, simple allocation, and ease of programming in general.\nConcepts: Inhalation vapour solution (Inhalation dosage form)\tAny recent sinus infections (Intellectual Product)\tGlobally Unique Identifier (Unique Identifier)\tCryoprotective Solutions (Substance)\tRECEPT DRUG (receptor)", + "output": "Globally Unique Identifier (Unique Identifier)" + }, + { + "input": "Definition: carboxylic acid transmembrane transport described as the process in which quinolinic acid is transported across a membrane.\nConcepts: Collection, Blood Products (Laboratory Procedure)\tGrade 1 Tracheostomy site bleeding (Tracheostomy Site Bleeding, CTCAE)\tquinolinic acid transmembrane transport (drug transmembrane transport)\tProcesses, Physiological (Authorized Osteopathic Thesaurus)\tiocs (Occipital lobe)", + "output": "quinolinic acid transmembrane transport (drug transmembrane transport)" + }, + { + "input": "Definition: Soft Tissue Sarcoma of the Trunk and Extremities TNM Finding v8 described as a clinical finding about one or more characteristics of soft tissue sarcoma of the trunk and extremities, following the rules of the TNM AJCC v8 classification system.\nConcepts: adult somatic muscle development (somatic muscle development)\tSoft Tissue Sarcoma of the Trunk and Extremities Clinical TNM Finding v8 (Soft Tissue Sarcoma of the Trunk and Extremities TNM Finding v8)\tDegenerative Spermatocyte Homolog 1, Lipid Desaturase (Drosophila) Gene (DEGS1 gene)\tlung lobe formation (Organ or Tissue Function)\tDon't Feel Very Good About the Way My Physician Talks to Me (Clinical or Research Assessment Question)", + "output": "Soft Tissue Sarcoma of the Trunk and Extremities Clinical TNM Finding v8 (Soft Tissue Sarcoma of the Trunk and Extremities TNM Finding v8)" + }, + { + "input": "Definition: Sciuromorpha described as a family of nocturnal rodents, similar in appearance to SQUIRRELS, but smaller. There are 28 species, half of which are found in Africa.\nConcepts: Gliridae (Families muridae AND/OR gliridae)\tPerihilar Bile Duct Cancer Clinical TNM Finding v7 (Perihilar Bile Duct Cancer TNM Finding v7)\tAcraniate monster, NOS (Monster)\tBehavior, Exploratory (Individual Behavior)\tIncisions (Surgical incisions)", + "output": "Gliridae (Families muridae AND/OR gliridae)" + }, + { + "input": "Definition: Drug Administration Routes described as administration to the nose; administered by way of the nose.\nConcepts: Severe Adverse Event (Adverse Event by CTCAE v3 Severity Grade)\tDistraction therapy (Psychosocial intervention strategy)\tdown-regulation of central tolerance induction (Physiologic Function)\tNasal use (Respiratory tract route)\tTupaia Raffles, 1821 (Tupaiidae)", + "output": "Nasal use (Respiratory tract route)" + }, + { + "input": "Definition: something described as surgical instrument motors and accessories are AC-powered, battery-powered, or air-powered devices intended for use during surgical procedures to provide power to operate various accessories or attachments to cut hard tissue or bone and soft tissue. Accessories or attachments may include a bur, chisel (osteotome), dermabrasion brush, dermatome, drill bit, hammerhead, pin driver, and saw blade.\nConcepts: Psychomotor degeneration (Mental deterioration)\tHospital Data Management Information System Software (Intellectual Product)\tEnuresis, NOS (Special symptoms or syndromes, NEC in ICD9CM 2014)\tMOTOR, SURGICAL INSTRUMENT, AC-POWERED (Medical Device)\tTRAIL-induced apoptotic signaling pathway (Cell Function)", + "output": "MOTOR, SURGICAL INSTRUMENT, AC-POWERED (Medical Device)" + }, + { + "input": "Definition: Combined Modality Therapy described as treatment that combines chemotherapy with radiotherapy.\nConcepts: EDUC DENT (Educational Activity)\tUnspecified osteonecrosis (Skeletal)\tEndoscopes, Gastrointestinal Tract, Upper Tract, Single Balloon (Endoscopes, Gastrointestinal Tract, Upper Tract)\tTFG/ALK Fusion Gene (Fusion Gene)\tradiochemotherapy (Pharmacotherapy)", + "output": "radiochemotherapy (Pharmacotherapy)" + }, + { + "input": "Definition: Medical Device described as laboratory blood analyzers used to evaluate the adhesion of red cells (erythrocytes) to one another. Erythrocyte aggregation analyzers typically determine aggregation indirectly by measuring the changes in light transmission with a photometer, while the flow velocity of a blood sample is adjusted over the range of interest. By applying and releasing mechanical shear forces to the blood, high enough to cause total disaggregation, they make it possible to assess the difference between normal and pathological red cell aggregation. These analyzers are an alternative to erythrocyte sedimentation rate analysis, with some potential advantages, such as a smaller blood sample and faster screening of some disease risks (e.g., cardiovascular disease).\nConcepts: Candidiasis, Chronic Mucocutaneous (Skin, Human)\tWnt Pathway (Signal Transduction)\tB-lymphocyte cytokine production (Cell Function)\tErythrocyte Aggregation Analyzers (Medical Device)\tEndocrinology (Internal medicine specialty)", + "output": "Erythrocyte Aggregation Analyzers (Medical Device)" + }, + { + "input": "Definition: Retinopathies NEC described as any noninflammatory disease of the retina. This nonspecific term is retained here because of its wide use in the literature, but if possible new annotations should indicate the precise type of retinal abnormality.\nConcepts: FAC075-Used Wrong Word When Refer Object (FACT-COG Version 3 Questionnaire Question)\tRetinopathy N0S (Other retinal disorders)\tRemunerative employment (Work and employment)\tRetinoblastoma pT3d TNM Finding v8 (Retinoblastoma pT3 TNM Finding v8)\tHydrargyrum (Element or Ion)", + "output": "Retinopathy N0S (Other retinal disorders)" + }, + { + "input": "Definition: Catheters, Vascular, Umbilical described as umbilical vascular catheters designed for insertion in the umbilical artery and are advanced to locate their distal tip in the thoracic aorta or, less frequently, in the abdominal aorta (usually in a high-level location T5 to T12 or a low level-location L2 to L5). These catheters typically consist of a single-lumen tube or 5 Fr for large infants and 3.5 Fr for smaller ones. Umbilical arterial catheters are used for blood gas monitoring (e.g., blood oxygen), infusion of liquids (e.g., glucose) and medication, and blood sampling; they are sometimes also used for blood transfusion, parenteral nutrition, and hyperalimentation.\nConcepts: response to M-CSF (response to cytokine)\tAppendicular hypotonia (Muscle hypotonia)\tumbilical arterial catheter (Medical Device)\tControllers, Air/Nitrogen Pressure (Medical Device)\tMART-1 Reactive CD8+ T-lymphocytes (therapeutic autologous lymphocytes)", + "output": "umbilical arterial catheter (Medical Device)" + }, + { + "input": "Definition: WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 12 + 24-Item Interviewer - Living situation at time of interview.\nConcepts: T-CELL GLYCOPROTEIN CD8B (Cell Adhesion Molecule Gene)\tWD4F5 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tActivity Score, Tegner (Intellectual Product)\tCongenital Nephrotic Syndrome - Focal Segmental Glomerulosclerosis (Disease or Syndrome)\tTherapeutic contact lens (Contact Lenses)", + "output": "WD4F5 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: Chronic lung disease described as a respiratory malfunction for which mental factors play a causative role.\nConcepts: Study Reference Uniform Resource Locator (Uniform Resource Locator)\tEyelid Carcinoma pTX TNM Finding v8 (Finding)\tUrinary System Findings Sponsor-Defined Identifier (Intellectual Product)\tPsychogenic respir dis (Somatoform autonomic dysfunction)\tGroup-x (vestibulomotor regions)", + "output": "Psychogenic respir dis (Somatoform autonomic dysfunction)" + }, + { + "input": "Definition: something described as a regimen consisting of epoetin alfa that may be used in the management of anemia secondary to chemotherapy, HIV infection, or chronic kidney disease (CKD); and in the prevention of anemia in certain patients undergoing elective non-cardiac surgical procedures.\nConcepts: Neonatal electrocardiographic electrode (Medical Device)\tEpoetin Alfa Regimen (Regimen Used to Treat Non-neoplastic Hematologic Disorders)\tFormal associations (Community life)\tGastrosplenic ligament (Greater omentum)\tCD4 Antigen (Amino Acid, Peptide, or Protein)", + "output": "Epoetin Alfa Regimen (Regimen Used to Treat Non-neoplastic Hematologic Disorders)" + }, + { + "input": "Definition: Antineoplastic Agents described as a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1263\" active clinical trials using this agent.\nConcepts: Childhood Intracranial Neoplasm (Neoplasms, Intracranial)\tbiodegradable product (Biomedical or Dental Material)\tTrilostanum (Antineoplastic Agents)\tMarked muscular hypertrophy (Finding)\tKlinefelter Sexual Disorder Determination Reagents (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Sexual)", + "output": "Trilostanum (Antineoplastic Agents)" + }, + { + "input": "Definition: Peritoneal Neoplasms described as a benign or malignant mesothelial neoplasm that arises from the peritoneum.\nConcepts: Change in Uterine Shape (Sign or Symptom)\tMesothelioma of Peritoneum (Mesothelioma)\tCarbon monoxide diffusing capacity decreased (Laboratory test result abnormal)\tmyocardial infarct sizing (heart disorder diagnosis)\tDFNB1A (Disease or Syndrome)", + "output": "Mesothelioma of Peritoneum (Mesothelioma)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - In the past 30 days: How much of a problem did you have in joining in community activities (for example, festivities, religious or other activities) in the same way as anyone else can?\nConcepts: 15-hydroxyicosatetraenoate dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tRetinoid Related Orphan Receptor alpha (Circadian Rhythm Signaling Peptides and Proteins)\tWD7D6 1 (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)\tregulation of cardiomyocyte differentiation (regulation of cardiac muscle tissue development)\tLipid Bilayers (Membrane Lipids)", + "output": "WD7D6 1 (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: something described as terminology associated with the reproductive system findings test name codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: SDTM-RPTEST (Intellectual Product)\tLactobacillus salivarius Rogosa et al. 1953 (Approved Lists 1980) emend. Li et al. 2006 (Bacterium)\tSouth Australia (Australia)\tIVD Panels, Human Genetics, Multisystem Disorder, Stickler Syndrome, Mutation (Medical Device)\tIntestinal Mucosa (Structure of soft tissues of abdomen)", + "output": "SDTM-RPTEST (Intellectual Product)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of the three larger salivary glands including the parotid, submandibular and sublingual glands.\nConcepts: RHODOTORULA GLUTINIS (Rhodotorula )\tSLC16A4 wt Allele (Gene or Genome)\tClobazam [epilepsy only] (Gamma-aminobutyric Acid (GABA) Augmenting Agents)\tMajor salivary glands set (Body Part, Organ, or Organ Component)\tInterphalangeal Joint 3 of the Hand (Interphalangeal Joint 3)", + "output": "Major salivary glands set (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a morphologic variant of the glomus tumor with architectural features similar to solid glomus tumor. It is characterized by the presence of elongated glomus cells which resemble mature smooth muscle.\nConcepts: L/min/pg (Quantitative Concept)\tIVD Test Reagent/Kits, Microbiology, Virus, Identification, Respiratory Syncytial Virus (Medical Device)\tAnti-FLT3 Monoclonal Antibody 4G8-SDIEM (Pharmacologic Substance)\tNEOPL SYNDROMES HEREDITARY (Genetic Diseases, Inborn)\tGlomangiomyoma (Benign neuroendocrine neoplasm - category)", + "output": "Glomangiomyoma (Benign neuroendocrine neoplasm - category)" + }, + { + "input": "Definition: Growth Factor Gene described as this gene is involved in mitogenesis for chondrocytes.\nConcepts: LYMRCTLY (Laboratory Procedure)\tDevice Size Text (Qualitative Concept)\tCCN2 Gene (Gene or Genome)\tMolecular Motor Proteins (Amino Acid, Peptide, or Protein)\tPartial excision parotid gland (Partial excision of salivary gland)", + "output": "CCN2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Satisfaction with Care described as extent of positive perception of information exchanged between client and nursing staff\nConcepts: Intermediate Care Facilities (Manufactured Object)\tClient satisfaction: communication (Finding)\tcellular response to prostaglandin I stimulus (cellular response to organic cyclic compound)\tHypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency (Hypercholesterolemia)\tThousand United States Pharmacopeia Unit (Quantitative Concept)", + "output": "Client satisfaction: communication (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the antithrombin activity in a biological specimen.\nConcepts: TINZAPARIN (Pharmacologic Substance)\tAntithrombin III assay, NOS (Thrombophilia screening)\tFinnegan's Neonatal Abstinence Scoring Tool (Intellectual Product)\tUrinary Incontinence Care (Elimination Management)\tPIM447 (Antineoplastic Enzyme Inhibitor)", + "output": "Antithrombin III assay, NOS (Thrombophilia screening)" + }, + { + "input": "Definition: Neoplastic Process described as a central nervous system embryonal neoplasm that occurs during childhood.\nConcepts: Antiparasitic Agent [TC] (GENERAL TERMS, ANTIHISTAMINES AND ANTI-INFECTIVE DRUGS)\tCentral Nervous System Embryonal Neoplasm (Malignant Childhood Central Nervous System Neoplasm)\tmicroorganism culture (Laboratory Procedure)\tsmoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation (cell surface receptor signaling pathway involved in heart development)\tAsthma Daytime Symptom Diary v1.0 Questionnaire Test Code (CDISC Questionnaire Terminology)", + "output": "Central Nervous System Embryonal Neoplasm (Malignant Childhood Central Nervous System Neoplasm)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents used in immunological tests to determine one or more of the slightly different alleles of cell-surface proteins coded in the locus C of the class I genes of the major histocompatibility complex. These tests are mostly used to match donor and recipient tissues before transplants (e.g., kidney, bone marrow).\nConcepts: Deafness both ears (Deafness)\tinorganic cation import into cell (Molecular Function)\tTranscription Factor STAT2 (Biologically Active Substance)\tIVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class I, C Loci (Medical Device)\tsurgery jaw (Other operations on jaw)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class I, C Loci (Medical Device)" + }, + { + "input": "Definition: Chromosome 6 Physical Location described as physical location of EEF1A1_Gene\nConcepts: 6: 74287475-74283962 (Chromosome 6 Physical Location)\tPM (Intellectual Product)\tIntraocular Pressure Rise, (General visual observation)\tsaturn (Geographic Area)\tHistory of Cancer (CPTAC Questions)", + "output": "6: 74287475-74283962 (Chromosome 6 Physical Location)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as converts BIG ENDOTHELIN to ENDOTHELIN-1 through hydrolysis of the TRYPTOPHAN (21)-VALINE (22) bond. Mutations in the endothelin-converting enzyme 1 (ECE1) gene are associated with cases of HIRSCHSPRUNG DISEASE with cardiac defects and autonomic dysfunction.\nConcepts: Ovarian Steroid Cell Tumor, NOS (Neoplastic Process)\tBRADYKININ B 02 RECEPTOR (Receptor)\tTriptoreline (Luteinizing Hormone-releasing Hormone Agonist)\tECE-1 (Amino Acid, Peptide, or Protein)\tCRQ-SAS First Administration Version - Had Control of Breathing Problems (Intellectual Product)", + "output": "ECE-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Neoplastic Process described as a rare aggressive malignant epithelial carcinoma of the esophagus characterized, macroscopically, by an exophytic mass with central ulceration located on the esophagus and histologically by a sheet-like growth of neoplastic cells without significant glandular, squamous or neuroendocrine differentiation. Patients may present with progressive dysphagia, long-standing history of gastroesophageal reflux, weight loss, anemia, abdominal or chest pain/pressure, dyspnea, and/or hematemesis. Presence or history of Barrett esophagus is frequently associated.\nConcepts: negative regulation of viral transcription by host (modulation by host of symbiont process)\tReduced WASp Expression (Finding)\ttransforming growth factor beta receptor type III binding (transforming growth factor beta receptor binding)\tUndifferentiated carcinoma of esophagus (Neoplastic Process)\tVeins, Iliac (Iliac vessel)", + "output": "Undifferentiated carcinoma of esophagus (Neoplastic Process)" + }, + { + "input": "Definition: NCI Thesaurus described as an organizational header for concepts representing mostly abstract entities.\nConcepts: organic acid metabolism (Molecular Function)\tNeonatal Culture Positive Sepsis, AE (Neonatal Adverse Event)\tSpermatozoa, Abnormal (Sperm morphology)\tHOXA9/MSI2 FUSION GENE (Gene or Genome)\tConceptual Entity (Conceptual Entity)", + "output": "Conceptual Entity (Conceptual Entity)" + }, + { + "input": "Definition: something described as a subtype of INFLUENZA A VIRUS that is highly virulent in poultry and wild birds, but shows varying degrees of pathogenicity in mice. The H5N8 virus subtype has a polybasic amino acid motif at the HA cleavage site which explains its pathogenicity in birds, and expresses surface proteins HEMAGGLUTININ 5 and NEURAMINIDASE 8 which are typical of Highly Pathogenic Avian Influenza viruses.\nConcepts: Viruses, H5N8 (Virus)\tLaser Nephelometers (Medical Device)\tAllogeneic HPV-specific Cytotoxic T Lymphocytes (Cell)\tOvoid (shape of nodule)\tPosterior septal branch of anterior interventricular artery (Body Part, Organ, or Organ Component)", + "output": "Viruses, H5N8 (Virus)" + }, + { + "input": "Definition: Idea or Concept described as personality construct referring to an individual's perception of the locus of events as determined internally by his or her own behavior versus fate, luck, or external forces. (ERIC Thesaurus, 1996).\nConcepts: Analgesic topical substance application each application (Laboratory Procedure)\tAscending frontal gyrus (Cerebral gyrus)\tKFSS - Visual (or Optic) Functions (KFSS Questionnaire Question)\tControls, External-Internal (Idea or Concept)\tchromium ion transmembrane transporter activity (ion transmembrane transporter activity)", + "output": "Controls, External-Internal (Idea or Concept)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Children (TSCC) Touching my private parts too much.\nConcepts: CTX/DOX/EST/5-FU/MTX/TMX (Agent Combination Not Indexed in Open Clinical Trials)\tpropionate metabolism, methylcitrate cycle (propanoate metabolism)\toral ixabepilone (Organic Chemical)\tTSCC01-Touching Private Parts Too Much (TSCC Questionnaire Question)\tDeoxydemoxepam (N [Preparations])", + "output": "TSCC01-Touching Private Parts Too Much (TSCC Questionnaire Question)" + }, + { + "input": "Definition: Cell described as INTERNEURONS with projections to the contralateral side of the SPINAL CORD. Both excitatory and inhibitory interneurons are involved in coordinating alternative left-right activities during LOCOMOTION.\nConcepts: up regulation of actin nucleation (regulation of actin nucleation)\tCommissural Interneuron (Interneurons)\tzygotene (Cell Function)\tIFN-DTIC Regimen (Regimen Used to Treat Melanoma)\tUDP-galactose:sn-glycerol-3-phosphate-2-D-galactosyl transferase activity (UDP-galactosyltransferase activity)", + "output": "Commissural Interneuron (Interneurons)" + }, + { + "input": "Definition: something described as liters per hour (flow rate), divided by milligrams per day (daily dose) or milliliters per hour (flow rate), divided by micrograms per day (daily dose).\nConcepts: valine degradation to isobutanol (isobutanol metabolic process)\trupture; abdominal aorta, aneurysm (Dissecting aortic aneurysm)\tAbnormal hepatic glycogen storage (Finding)\t(L/h)/(mg/d) (Quantitative Concept)\tMiddle Ear Surgery Chisels (Medical Device)", + "output": "(L/h)/(mg/d) (Quantitative Concept)" + }, + { + "input": "Definition: regulation of transferrin receptor binding described as any process that stops, prevents or reduces the frequency, rate or extent of transferrin receptor binding.\nConcepts: Cutaneous Melanoma by AJCC v6 Stage (Cutaneous Melanoma)\tdown regulation of transferrin receptor binding (Molecular Function)\tHDDC1 (Gene or Genome)\tESTHESIOMETER, OCULAR (Medical Device)\tFurocoumarins (Plant Extracts)", + "output": "down regulation of transferrin receptor binding (Molecular Function)" + }, + { + "input": "Definition: Structure of posterior renal segment described as renal segment supplied by the posterior segmental branch of right renal artery.\nConcepts: Posterior renal segment of right kidney (Body Part, Organ, or Organ Component)\tAuditory radiation (Auditory pathway structure)\tPosterior facial vein (Retromandibular vein and its tributaries)\tCNV-Contingent -ve variation (Electrophysiology)\tAutosomal dominant optic atrophy and peripheral neuropathy syndrome (Peripheral Nervous System Diseases)", + "output": "Posterior renal segment of right kidney (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Finding described as an electrocardiographic finding of an S1Q3 pattern and QRS axis greater than or equal to 120 degrees. It is usually seen in association with other abnormalities (e.g. RBBB or RVH).\nConcepts: Left Posterior Fascicular Block by EKG Finding (Heart Block by ECG Finding)\tregulation of protein targeting (Cell Function)\tFlat acetabular roof (Finding)\t^Fetus (embryo and fetus)\tMole per Liter per Milligram per Meter Squared (Measurement Unit Description)", + "output": "Left Posterior Fascicular Block by EKG Finding (Heart Block by ECG Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as agents used to treat RETROVIRIDAE INFECTIONS.\nConcepts: Radicular Dental Root Studs (Dental Root Studs)\tNon-Invasive Ventilations (Therapeutic or Preventive Procedure)\tAntiretroviral agents (Pharmacologic Substance)\ttocopherol omega-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tTubes, Tracheal, Laser-Resistant (Tracheal tube)", + "output": "Antiretroviral agents (Pharmacologic Substance)" + }, + { + "input": "Definition: Hypertrophic mitochondrial cardiomyopathy described as a rare genetic mitochondrial disorder due to a defect in mitochondrial protein synthesis with characteristics of infantile-onset severe hypertrophic cardiomyopathy (that occasionally progresses to dilated cardiomyopathy) associated with failure to thrive, global development delay, muscular hypotonia, elevated serum lactate and complex I deficiency in skeletal muscle biopsy. Intellectual disability, pericardial effusion and a mild cardiac phenotype have been also reported. Caused by homozygous or compound heterozygous mutation in the ELAC2 gene on chromosome 17p12.\nConcepts: AVPR1A (Vasopressin Receptor)\tLasers, Carbon Dioxide, Transmyocardial Revascularization (Medical Device)\tfumitremorgin B biosynthetic process (organic heteropentacyclic compound biosynthetic process)\tCOXPD17 - combined oxidative phosphorylation defect type 17 (Autosomal recessive hereditary disorder)\tUndesired Appetite Increase Score 7 (Undesired Appetite Increase Scale)", + "output": "COXPD17 - combined oxidative phosphorylation defect type 17 (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: meiosis I cell cycle phase described as the cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.\nConcepts: Epithelium of bronchiole (Simple cuboidal epithelium)\tzygotene (Cell Function)\tDRRI1G11 (DRRI-2 Questionnaire Question)\tPedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Get Sores and/or Rashes (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report Questionnaire Question)\tCongenital duplication of rectum (Congenital anomaly of rectum)", + "output": "zygotene (Cell Function)" + }, + { + "input": "Definition: Apansporoblastina described as any fungal organism that is not assigned to the species level but can be assigned to the Nosema genus level.\nConcepts: Nosema (PROTOZOA OF UNCERTAIN TAXONOMIC POSITION)\tHernias, Femoral (Acquired Abnormality)\tGrade 1 Neonatal Tachyarrhythmia (Finding)\txanthine analog (Organic Chemical)\tFAC028TC (Intellectual Product)", + "output": "Nosema (PROTOZOA OF UNCERTAIN TAXONOMIC POSITION)" + }, + { + "input": "Definition: DNA metabolic process described as the chemical reactions and pathways involving mitochondrial DNA.\nConcepts: mtDNA metabolic process (Genetic Function)\tETRP01-Medication Total Points (Intellectual Product)\tazetidine-2-carboxylic acid acetyltransferase activity (N-acetyltransferase activity)\tBenzenesulfonic Acid, 3,3'-(4,5,6,7-Tetrabromo-3-Oxo-1(3H)-Isobenzofuranylidene)Bis(6-Hydroxy)- (Dyes)\tMotolimod (Immunologic Adjuvants)", + "output": "mtDNA metabolic process (Genetic Function)" + }, + { + "input": "Definition: something described as promotional materials directed to health care professionals. FDA Form 2253\nConcepts: professional (Publications)\tAxis Inhibition Protein 2 (Amino Acid, Peptide, or Protein)\tcyclin-dependent protein kinase activity (Molecular Function)\tURLC10 peptide/Montanide ISA51 vaccine (Pharmacologic Substance)\tWhen I do have pain, it is very mild (Intellectual Product)", + "output": "professional (Publications)" + }, + { + "input": "Definition: Neoplasm of intrathoracic organs described as new abnormal tissue of the lung that grows by excessive cellular division and proliferation more rapidly than normal and continues to grow after the stimuli that initiated the new growth cease.\nConcepts: GAIA Level 3 Major External Structural Defect (GAIA Major Congenital Anomalies Level of Diagnostic Certainty)\tNeoplasm, Pulmonary (Respiration Disorders)\tbA416N4.2 (SNAP25 gene)\tArctic Research (Research Activity)\tSacral lymph node (Lymph node group)", + "output": "Neoplasm, Pulmonary (Respiration Disorders)" + }, + { + "input": "Definition: Post-Translational Protein Processing described as the proteolytic cleavages to the Notch protein that occur prior to ligand binding. A primary cleavage event within the extracellular domain whilst the Notch protein in still in the secretory pathway, leads to the transportation of a processed heterodimer to the cell surface.\nConcepts: Notch receptor processing, ligand-independent (Molecular Function)\tGrade 4 Pancreatic hemorrhage (Finding)\tPUMP, INFUSION OR SYRINGE, EXTRA-LUMINAL (Medical Device)\tSUBURBAN HEALTH SERV (Health Care Activity)\tType II Site-Specific Deoxyribonucleases (Hydrolase)", + "output": "Notch receptor processing, ligand-independent (Molecular Function)" + }, + { + "input": "Definition: Device Labeled for Single Use described as a small device designed to hold and attach items together.\nConcepts: upregulation of matrix metallopeptidase secretion (positive regulation of protein secretion)\tClip, device (Device Component or Accessory)\tPcdha7-Pcdhgb2 complex location (Cell Component)\tFood and Water Consumption Test Code (Intellectual Product)\tBRCC2 (Tumor Suppressor Genes)", + "output": "Clip, device (Device Component or Accessory)" + }, + { + "input": "Definition: Finding described as more than two clockwise hair whorls.\nConcepts: Bone Marrow Failure (WHITE CELL AND RES DISORDERS)\taxon hillock (Cell Component)\tMethylphenidate (Centrally acting sympathomimetics)\tmL.cm[H2O] (Manometric Unit of Pressure)\tAbnormal number of hair whorls (Abnormal hair whorl)", + "output": "Abnormal number of hair whorls (Abnormal hair whorl)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a questionnaire included in the Behavior Rating Inventory of Executive Function. The teacher form is completed by any adult with extended contact with the child in an academic setting, typically a teacher, but an aide is acceptable. The adult must have at least 1 month familiarity with the child.\nConcepts: Exercisers, Patient Lifting (Medical Device)\tBPRS01-Blunted Affect (BPRS 1988 Version Clinical Classification Question)\tMyofibroblastic Differentiation (Tissue Differentiation)\tregulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway (Physiologic Function)\tTeacher Form Questionnaire (Intellectual Product)", + "output": "Teacher Form Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Cholestenes described as CHOLESTENES with one or more double bonds and substituted by any number of keto groups.\nConcepts: endostatins (Angiostatic Proteins)\tChromatin Modification-Related Protein MEAF6 (Transcription Regulatory Protein)\tmelilotic hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\toxytetracycline catabolism (Molecular Function)\tCholestenones (Organic Chemical)", + "output": "Cholestenones (Organic Chemical)" + }, + { + "input": "Definition: Pyoderma Gangrenosum described as a rare pleiotropic auto-inflammatory disorder of childhood, primarily affecting the joints and skin. The first affected family contained ten affected members from three generations and manifested variable expression of a pauciarticular, nonaxial, arthritis that began in childhood; pyoderma gangrenosum; and severe cystic acne in adolescence and beyond. Recurrent sterile arthritis usually occurs after minor trauma, but can also occur spontaneously. PAPA syndrome is a self-limiting disease, but it can lead to severe joint destruction. The gene responsible for the syndrome is the proline-serine-threonine phosphatase interacting protein 1 (PSTPIP1).\nConcepts: CDISC SDTM Pharmacogenomics Findings Test Name Terminology (Intellectual Product)\tcaBIO Entity (Computer Programming Object)\tPyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne (Disease or Syndrome)\tUrinary Frequency (Renal and Urinary Disorders, CTCAE)\tOxyphil cell of thyroid (Cell)", + "output": "Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, and Acne (Disease or Syndrome)" + }, + { + "input": "Definition: Employee, Occupational & Job Characteristics described as possessing the knowledge and qualifications of a particular profession.\nConcepts: H2BC1 (Gene or Genome)\tDrop Suspension (Suspensions)\tCoyotillos (Plant)\tCompetence, Professional (Employee, Occupational & Job Characteristics)\tLabile Factor Activity (Laboratory Procedure)", + "output": "Competence, Professional (Employee, Occupational & Job Characteristics)" + }, + { + "input": "Definition: something described as a quantitative measurement for assessing the amount of glucose present in a blood sample.\nConcepts: AMCN (Hereditary disorder of musculoskeletal system)\testivation (Organism Function)\tPERIPANCREATIC LYMPH NODE (Body Part, Organ, or Organ Component)\tBlood glucose (Metabolic Problems)\tcprhnsv bacteriology ea.tst (Laboratory Procedure)", + "output": "Blood glucose (Metabolic Problems)" + }, + { + "input": "Definition: UML Entity described as disease objects specify a disease name and ID; disease objects also provide access to: ontological relations to other diseases; clinical trial protocols treating the disease; and specific histologies associated with instances of the disease.\nConcepts: Cusps, Dental (Medical Device)\tDisease Ontology (Conceptual Entity)\tUHDR1-Gainful Employment Accustomed Work (Intellectual Product)\tRCPCTAU (Quantitative Concept)\tinner zone antigen, human (Amino Acid, Peptide, or Protein)", + "output": "Disease Ontology (Conceptual Entity)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the Functional Assessment of Chronic Illness Therapy-Fatigue 13-Item Scale Version 4 (FACIT-Fatigue 13-Item Version 4) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: 4SCAR22 T cells (Antineoplastic Immune Cell)\tOver half the days (Temporal Qualifier)\tCDISC Questionnaire FACIT-Fatigue 13-Item Version 4 Test Code Terminology (CDISC Questionnaire Terminology)\tCell surface antigens (Immunologic Factor)\tBenign familial megalencephaly (Congenital Abnormality)", + "output": "CDISC Questionnaire FACIT-Fatigue 13-Item Version 4 Test Code Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Neoplastic Process described as a benign adipose tissue neoplasm of the esophagus. Clinical presentation includes obstruction, dysphagia, regurgitation, vomiting and reflux. It may be associated with aspiration and consecutive respiratory infections.\nConcepts: NEDD-8 (Gene or Genome)\tProtocol Monitor (Professional or Occupational Group)\tmyringotomy tubes (biomedical tube device)\tMisassembly during Maintenance/Repair (Finding)\tLipoma of the Esophagus (Lipoma)", + "output": "Lipoma of the Esophagus (Lipoma)" + }, + { + "input": "Definition: something described as an abnormality of the septum pellucidum, which is a thin, triangular, vertical membrane separating the lateral ventricles of the brain.\nConcepts: At risk of impaired cardiac function (Finding)\tAbnormality of the septum pellucidum (Abnormal cerebral morphology)\tAtresia, Jejunal (Jejunal Atresia)\tregulation of cellular response to stress (regulation of cellular process)\tAs bad as it can be (Finding)", + "output": "Abnormality of the septum pellucidum (Abnormal cerebral morphology)" + }, + { + "input": "Definition: Population Group described as a Chinese person from the Sui ethnic group.\nConcepts: criminal (Criminal Groups)\tSUI (Ethnic group)\tMycobacterium fortuitum - chelonae complex (Genus Mycobacterium)\tAughton Hufnagle syndrome (Multiple system malformation syndrome)\tCDISC Questionnaire IPAQ Short Last 7 Days Telephone Format Version Test Name Terminology (Intellectual Product)", + "output": "SUI (Ethnic group)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: propionyl-CoA + histone = CoA + propionyl-histone.\nConcepts: Tibial Knee Joint Prostheses (Knee joint prosthesis)\thistone propionyltransferase activity (protein propionyltransferase activity)\thealth levels (ActCoverageAssessmentObservationValue)\tL-fucose aldose-ketose-isomerase activity (Molecular Function)\tThe pain I have is almost unbearable (Clinical or Research Assessment Answer)", + "output": "histone propionyltransferase activity (protein propionyltransferase activity)" + }, + { + "input": "Definition: something described as anthrax toxin receptor 1 (564 aa, ~63 kDa) is encoded by the human ANTXR1 gene. This protein plays a role in the regulation of both cell adhesion and cellular motility.\nConcepts: otolith formation (anatomical structure formation involved in morphogenesis)\tSMELL PERVERSION (Finding of sense of smell)\tRegimen Used to Treat Malignant Fallopian Tube Neoplasm (Chemo/immuno/hormone Therapy Regimen)\tAnthrax Toxin Receptor 1 (Amino Acid, Peptide, or Protein)\tBTB-Zinc Finger Protein Expressed In Effector Lymphocytes (Biologically Active Substance)", + "output": "Anthrax Toxin Receptor 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Disorder of trunk described as abnormal narrowing of the lumen of the inferior vena cava.\nConcepts: NCI CTEP SDC Myelodysplastic Syndrome Sub-Category Terminology (Intellectual Product)\tWhite matter necrosis (Congenital anomaly of head)\tInferior vena cava stenosis (Stricture of vein)\tsprtlnrse relgs prcts fsilta (Health Care Activity)\tAnalysis Method (Research Activity)", + "output": "Inferior vena cava stenosis (Stricture of vein)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Young Children (TSCYC) Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Not going to bed at night the first time he or she was asked.\nConcepts: StudyResource.effectiveDateRange (Temporal Concept)\tEesophageal stent (Stent, device)\tDENND2B Gene Product (Biologically Active Substance)\tEnterobacter sakazakii Farmer et al. 1980 (Enterobacter)\tTSCYC - Not Going to Bed First Time Asked (TSCYC Questionnaire Question)", + "output": "TSCYC - Not Going to Bed First Time Asked (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: SKIN AND MUCOUS MEMBRANE ANTIFUNGAL AGENTS described as the copper salt of undecylenic acid, an 11 carbon mono-unsaturated fatty acid with broad-spectrum antifungal activity. Undecylenic acid inhibits the morphogenesis of Candida albicans to its invasive fungal form and inhibits conversion of unicellular yeast to their hyphal form.\nConcepts: HCS - When You Are in Social Situations (Intellectual Product)\tGLURC (Gene or Genome)\tCopper Undecylenate (Organic Chemical)\t4q26-q32 (Cell Component)\tprotein maturation by [2Fe-2S] cluster transfer (protein maturation by iron-sulfur cluster transfer)", + "output": "Copper Undecylenate (Organic Chemical)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable small molecule inhibitor of the Wnt signaling pathway, with potential antineoplastic activity. Upon oral administration, Wnt signaling inhibitor SM04755 targets and binds to an as of yet undisclosed target in the Wnt signaling pathway, thereby preventing Wnt-mediated signaling. This may inhibit growth of tumor cells in which the Wnt signaling pathway is overactivated. The Wnt signaling pathway is upregulated in many cancers and plays a key role in tumor cell proliferation.\nConcepts: EDSS (Clinical Classification)\talpha-keto ester reductase activity (Molecular Function)\tForetinib (Pharmacologic Substance)\tWnt Signaling Inhibitor SM04755 (Signal Transduction Inhibitor)\tPerformed Study Agent Transfer (Performed Clinical Study Activity)", + "output": "Wnt Signaling Inhibitor SM04755 (Signal Transduction Inhibitor)" + }, + { + "input": "Definition: Radioconjugate described as a radiopharmaceutical agent comprised of a pegylated dimeric arginine-glycine-aspartic acid (RGD)-based peptide labeled with 2-fluoropropionyl, with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). The RGD moiety of 2-fluoropropionyl-labeled pegylated dimeric RGD peptide targets and binds to alphaVbeta3 integrin. Upon PET imaging, alphaVbeta3 integrin-expressing tumor cells can be visualized and expression levels can be quantified. Compared to other fluorine F 18 labeled RGD-containing peptides, this agent shows increased affinity to alphaVbeta3 integrin, enhanced tumor uptake as well as improved pharmacokinetics. alphaVbeta3 integrin, overexpressed on certain tumor cells and tumor endothelial cells, plays a key role in angiogenesis, tumor proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97336\" active clinical trials using this agent.\nConcepts: 2-fluoropropionyl-labeled pegylated dimeric RGD peptide (Pharmacologic Substance)\tConjugated Linoleic Acid n-6 (Organic Chemical)\tArterial endothelium (Blood Vessel Endothelium)\tBody Weight Gain Test Code (Intellectual Product)\tNeovascularization, choroidal (Ocular vascular disorders NEC)", + "output": "2-fluoropropionyl-labeled pegylated dimeric RGD peptide (Pharmacologic Substance)" + }, + { + "input": "Definition: Cell Component described as a myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.\nConcepts: Steroid Cream (Chemical Viewed Functionally)\tingrowing toenail (Diseases Component)\tReference To Study Results (Intellectual Product)\tmyosin VI complex location (unconventional myosin complex)\tX-linked intellectual disability Stocco Dos Santos type (Genetic Diseases, X-Linked)", + "output": "myosin VI complex location (unconventional myosin complex)" + }, + { + "input": "Definition: something described as delivery by Caesarian section representing the first time the mother has delivered by Caesarian section.\nConcepts: Primary Caesarian section (Cesarean section)\tSenile cataract NOS (Lens Diseases)\tHyperacusis (Other abnormal auditory perceptions)\tcapreomycin phosphotransferase activity (Molecular Function)\tcarumonam (Antibiotic)", + "output": "Primary Caesarian section (Cesarean section)" + }, + { + "input": "Definition: something described as a chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.\nConcepts: CD171 CAR+ T cells (Antineoplastic Immune Cell)\tProgressive extrapyramidal muscular rigidity (Finding)\tFormyl Peptide Receptor 1 Signaling Pathway (Molecular Function)\tbronchitic asthma (respiratory obstructive disorders)\tvoice weakness (Abnormality of the voice)", + "output": "bronchitic asthma (respiratory obstructive disorders)" + }, + { + "input": "Definition: Population Group described as the group receiving the study agent that is being tested in a clinical trial or clinical study.\nConcepts: um (SI Unit of length)\tGrade 2 Central Nervous System Necrosis, CTCAE (Central Nervous System Necrosis, CTCAE)\tintervention group (Population Group)\tPancreatic Neuroendocrine Tumor pM1 TNM Finding v8 (Pancreatic Neuroendocrine Tumor Pathologic Distant Metastasis TNM Finding v8)\tdelta-carotene biosynthetic process (carotenoid biosynthesis)", + "output": "intervention group (Population Group)" + }, + { + "input": "Definition: CDISC CDASH Terminology described as a terminology subset of the CDISC Study Data Tabulation Model (SDTM) Frequency codelist created for Clinical Data Acquisition Standards Harmonization (CDASH) Concomitant Medication Dosing Frequency per Interval Terminology.\nConcepts: Sarcoma of the Orbit pNX TNM Finding v7 (Sarcoma of the Orbit Pathologic Regional Lymph Nodes TNM Finding v7)\tWNT inhibitory factor 1 (Signaling Pathway Gene)\tLurbinectedin (Organic Chemical)\tExistentialism (Philosophy)\tCDASH-CMDOSFRQ (CDISC CDASH Terminology)", + "output": "CDASH-CMDOSFRQ (CDISC CDASH Terminology)" + }, + { + "input": "Definition: Radiation described as that portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.\nConcepts: I felt uneasy (Clinical or Research Assessment Question)\tTRREFID (Intellectual Product)\tradiation ultraviolet (light spectrum)\taxillary node, 1 or more positive (Finding)\tPeroneal muscle atrophy (Disease or Syndrome)", + "output": "radiation ultraviolet (light spectrum)" + }, + { + "input": "Definition: something described as comparator against which the study treatment is evaluated.\nConcepts: TCNTRL (Research Activity)\tCholedochoscopes, Percutaneous (Choledochoscope)\tAQ01-Long Term Effects of Drugs (Intellectual Product)\tVaccine, Rotavirus (Pharmacologic Substance)\tISCDIND (Indicator)", + "output": "TCNTRL (Research Activity)" + }, + { + "input": "Definition: Knowledge Management described as storage, manipulation, management, and control of data for specific uses.\nConcepts: Management, Data (Information Storage and Retrieval)\tAfatinibum (Amides)\tPedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Hard to Gain or Lose Weight (Intellectual Product)\tepithelium pigmented retinal (Eye)\tCancer antigen 27.29 (Protein or Enzyme Type Measurement)", + "output": "Management, Data (Information Storage and Retrieval)" + }, + { + "input": "Definition: CHART-SF Interview Version Questionnaire Question described as craig Handicap Assessment and Reporting Technique-Short Form Interview Version (CHART-SF Interview Version) How much time is someone with you in your home to assist you with activities that require remembering, decision making, or judgment?\nConcepts: downregulation of sodium ion import across plasma membrane (Cell Function)\tLast Screening (Temporal Concept)\tCHSF1-Home Cognitive Assistance per Day (Intellectual Product)\tLacrimal Gland Carcinoma pT3 TNM Finding v8 (Lacrimal Gland Carcinoma Pathologic Primary Tumor TNM Finding v8)\tCOLPOSCOPY (Diagnostic Procedure)", + "output": "CHSF1-Home Cognitive Assistance per Day (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: UDP-alpha-D-glucose + kaempferol 3-O-glucoside <=> kaempferol 3,7-O-diglucoside + UDP.\nConcepts: urothelial cell proliferation (Cell Function)\tBenign Lung PEComa (Benign neoplasm of lung)\tDermoid cyst of neck (Benign neoplasm of neck)\tkaempferol-3-glucoside-glucosyltransferase activity (hexosyltransferase activity)\thistone lysine N-acetyltransferase activity (Molecular Function)", + "output": "kaempferol-3-glucoside-glucosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: transferase activity, transferring aldehyde or ketonic groups described as catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.\nConcepts: Cancer and Nutrition (Cancer Research)\tPortal hypertensions (Disorder of portal venous system)\tpolyadenylation-dependent RNA catabolic process (Genetic Function)\tsedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (Molecular Function)\tG2 to M Transition Process (Molecular Function)", + "output": "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a rare chromosomal anomaly syndrome with a highly variable phenotype. Principle characteristics are intellectual disability, growth and developmental delay, facial dysmorphism (including microphthalmia, deep-set eyes, low-set, malformed ears, bulbous nose, high-arched palate, micrognathia) and congenital heart defects (ventricular septal defect), as well as urogenital (hypoplastic genitalia, cryptorchidism), skeletal (congenital joint dislocations or hyperflexion, scoliosis/kyphosis) and central nervous system anomalies (hydrocephalus, Dandy-Walker malformation). Pigmentary mosaic skin lesions along the lines of Blaschko are also frequently observed.\nConcepts: Trisomy 9 mosaic (Disease or Syndrome)\tIncreased bone density of end part of the outermost ring finger bone (Abnormality of the epiphysis of the distal phalanx of the 4th finger)\tKidney, NOS (Genitourinary)\tL-amino-acid oxidase activity (oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor)\tSchisandraceae (Austrobaileyales)", + "output": "Trisomy 9 mosaic (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a unipolar chest lead used mostly in large animals. Placed on the sixth ICS on the right side of the thorax along a line parallel to the level of the point of the humeralradial joint.\nConcepts: Oligomycin (Macrolides)\tPolypoid sinus degeneration NOS (Finding of head and neck region)\tUnspecified otosclerosis (Disorder of ear ossicles)\tUTOMILUMAB (Immunologic Factor)\tLead Site CV5RL (Electrocardiograph Lead Placement Location)", + "output": "Lead Site CV5RL (Electrocardiograph Lead Placement Location)" + }, + { + "input": "Definition: Clinical or Research Facility described as the Molecular Diagnostics Laboratory Shared Resource provides support to Cancer Center investigators with specimen processing and tracking, DNA sequencing, microsatellite and SNP analyses, quantitative PCR, protein analysis as well as other services, to analyze genes and genes products that are, or may be, involved in the etiology of cancer.\nConcepts: colloidal oatmeal cream (Pharmacologic Substance)\tregulation of IL-1 production (regulation of cytokine production)\tmicroRNA 152 (MicroRNA Gene)\tlarval serum protein complex location (protein-containing complex)\tMolecular Diagnostics Laboratory Shared Resource (Clinical or Research Facility)", + "output": "Molecular Diagnostics Laboratory Shared Resource (Clinical or Research Facility)" + }, + { + "input": "Definition: establishment of protein localization to membrane described as the directed movement of a protein to a specific location in a postsynaptic membrane.\nConcepts: establishment of protein localization to postsynaptic membrane (protein localization to postsynaptic membrane)\tStage IVA Adenoid Cystic Carcinoma of Oral Cavity (Adenoid cystic carcinoma of the oral cavity stage IV)\tquinoline analog (Organic Chemical)\tGenetic Sequence Start Location (Laboratory Procedure)\tConditions (Unapproved attribute)", + "output": "establishment of protein localization to postsynaptic membrane (protein localization to postsynaptic membrane)" + }, + { + "input": "Definition: something described as a precursor lymphoid neoplasm composed of B-lymphoblasts which contain less than 46 chromosomes. It has an unfavorable clinical outcome.\nConcepts: C-SSRS Already Enrolled Subjects - Most Recent Suicide Attempt Actual Lethality/Medical Damage (Intellectual Product)\tB Lymphoblastic Leukemia/Lymphoma with Hypodiploidy (B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities)\tSpiritual nurse sudden need assessment and/or care each 15 minutes (Spiritual nursing care)\tventral striatum (Striatum of neuraxis)\tcellular bud neck septin structure (cellular anatomical entity)", + "output": "B Lymphoblastic Leukemia/Lymphoma with Hypodiploidy (B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities)" + }, + { + "input": "Definition: Other Finding described as an indication of the percentage of cancerous cells present in the tissue core with the greatest amount of tumor involvement.\nConcepts: Refractory Endometrial Squamous Cell Carcinoma (Refractory Endometrial Carcinoma)\tRatibidas (Heliantheae)\tHigh-Mobility Group Nucleosome Binding Domain 1 wt Allele (Gene or Genome)\tGreatest Percentage of Core Involvement by Cancer in Any Core (Finding)\tC130107 (Laboratory Procedure)", + "output": "Greatest Percentage of Core Involvement by Cancer in Any Core (Finding)" + }, + { + "input": "Definition: Antibiotics, Gynecological described as a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, thereby causing depolarization of the membrane and altering cell membrane permeability. This leads to leakage of important intracellular components, cell rupture, and eventually cell death. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.\nConcepts: Actomyosin (Biologically Active Substance)\tConcentrate and Solvent for Concentrate for Oral Spray, Suspension Dosage Form (Combined Dosage Form)\tHAMD-21 - Obsessional and Compulsive Symptoms (HAMD 21 Questionnaire Question)\tProduct containing amphotericin B (Antibiotics for systemic use)\tFax (Telecommunication Device)", + "output": "Product containing amphotericin B (Antibiotics for systemic use)" + }, + { + "input": "Definition: something described as from the Sigmodon genus of rodents, Sigmodon hispidus was the first animal model to be used in polio research. It has a stout body, small ears and a dark coat that can be dark brown or mixed buff and black, with a tail length that is 35% of its total body length. As its name suggests, this breed has a proclivity for cotton in its nesting, and is a natural Hanta viral reservoir.\nConcepts: positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration (positive regulation of cell activation)\tSigmodon hispiedis (Sigmodon)\tGonocyte (Embryonic genital structure)\tExercise Tolerance (Energy / stamina)\tAcids, Heterocyclic (Organic Chemical)", + "output": "Sigmodon hispiedis (Sigmodon)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy described as molecular assay reagents intended to identify gene variants associated with left ventricular noncompaction cardiomyopathy, a form of cardiomyopathy characterized by the failure of the ventricular myocardium (i.e., heart wall muscle) to properly compact, leaving muscular projections (i.e., trabeculations) into the ventricle. Genetic variants at multiple loci have been associated with left ventricular noncompaction cardiomyopathy. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple left ventricular noncompaction cardiomyopathy-associated loci simultaneously.\nConcepts: B65-B69 FAMILY COLUBRIDAE - COLUBRIDS (Colubroidea)\tGelatin Coated Capsule Dose Form (Oral coated capsule)\tHBOARBHB (Hemoglobin measurement)\tLVNC Gene Panel Reagents (Medical Device)\tProtein Gx Protein Variant (Cell or Molecular Dysfunction)", + "output": "LVNC Gene Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Cardinal cell part described as a lipid with 2 fatty acid chains attached to a carbohydrate-containing head group that is found on the outer leaflet of the plasma membrane.\nConcepts: MDCK Cells (Cultured Cell Line)\tPathologic Burden of New Tumor (Tumor Burden)\tPlasma Membrane Glycolipid (Cell Component)\tStudy Section (Population Group)\tFibrinogen decreased (Finding)", + "output": "Plasma Membrane Glycolipid (Cell Component)" + }, + { + "input": "Definition: Proteins described as proteins that bind specific drugs with high affinity and trigger intracellular changes influencing the behavior of cells; generally thought to be receptors for some endogenous substances not otherwise specified; postcoordinate with specific drug terms if needed.\nConcepts: Herbal (Intellectual Product)\tdrug receptors (Exogenous substance receptor site, NOS)\tDiagnostic-Related Group Outlier (Patient or Disabled Group)\tCommence (Activity)\tSequential (ContentProcessingMode)", + "output": "drug receptors (Exogenous substance receptor site, NOS)" + }, + { + "input": "Definition: Cytokine Release Syndrome, CTCAE described as life-threatening consequences; urgent intervention indicated\nConcepts: Grade 4 Cytokine Release Syndrome, CTCAE (Finding)\tbisphenol A hydroxylase A activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tRhesus Blood-Group Systems (Blood Group)\tSH2B2 gene (Adaptor Signaling Protein Gene)\tStudy Reference Uniform Resource Locator (Intellectual Product)", + "output": "Grade 4 Cytokine Release Syndrome, CTCAE (Finding)" + }, + { + "input": "Definition: something described as associated with bloody nasal discharge or epistaxis\nConcepts: t(X;18)(p11;q11) (Cell or Molecular Dysfunction)\tlast subject out/complete (LSC/LPC or LSO/LPO) - date, time) (Temporal Concept)\tDysfunctional gastrointestinal motility (gastrointestinal function)\tdown regulation of anthocyanin biosynthetic process (Molecular Function)\tGrade 3 Nasal congestion (Finding)", + "output": "Grade 3 Nasal congestion (Finding)" + }, + { + "input": "Definition: response to toxic substance described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon monoxide (CO) stimulus.\nConcepts: TSCYC177 (Intellectual Product)\tresponse to carbon monoxide (response to organic substance)\tSpecify Site If Distant Metastasis Submitted (Is Any Metastatic Diagnosis Present)\tag (GENERAL ANTIGENS AND ANTIGENIC PHENOMENA)\tup-regulation of chondrocyte differentiation (regulation of chondrocyte differentiation)", + "output": "response to carbon monoxide (response to organic substance)" + }, + { + "input": "Definition: Finding described as a disorder characterized by dysfunction of the olfactory nerve (first cranial nerve).\nConcepts: Olfactory Nerve Disorder, CTCAE (Finding)\tWHIVS2-WHO Clinical Stage of HIV/AIDS (Intellectual Product)\th.ng/mL/(mg/kg) (Measurement Unit Description)\txyloglucan formation (Molecular Function)\t10-deacetylbaccatin III 10-O-acetyltransferase activity (O-acetyltransferase activity)", + "output": "Olfactory Nerve Disorder, CTCAE (Finding)" + }, + { + "input": "Definition: something described as continuous and profound contemplation or musing on a subject or series of subjects of a deep or abstruse nature; contemplation of spiritual matters\nConcepts: Rickettsia trachomatis (Chlamydia)\tMeditation (alternative medical treatment)\toperation wound; dehiscence (Perioperative injury)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2 First Trimester Spontaneous Abortion (Intellectual Product)\tICAM3 (Intercellular Adhesion Molecule Measurement)", + "output": "Meditation (alternative medical treatment)" + }, + { + "input": "Definition: Fabaceae described as a plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.\nConcepts: Myelography Procedure Kit/Trays (Procedure Kit/Trays)\tGrade 4 Esophageal Anastomotic Leak, CTCAE (Finding)\tRAOULTELLA ORNITHINOLYTICA (Klebsiella)\tLupinus, NOS (Lupinus)\tday*mg/mL/kg (Quantitative Concept)", + "output": "Lupinus, NOS (Lupinus)" + }, + { + "input": "Definition: beta-glucosidase activity described as catalysis of the random hydrolysis of (1->6) linkages in (1->6)-beta-D-glucans.\nConcepts: Physiologic Recorders (Physiologic monitoring recorder)\tleukemia AML with CCAAT/enhancer binding protein alpha somatic mutation (Acute myeloid leukemia due to recurrent genetic abnormality)\tBehavioral Health & Social Service Providers; Psychologist, Rehabilitation (Professional or Occupational Group)\tendo-1,6-beta-glucanase activity (Molecular Function)\tMLR (Histocompatibility Testing)", + "output": "endo-1,6-beta-glucanase activity (Molecular Function)" + }, + { + "input": "Definition: Acid-base disorders described as excess retention of carbon dioxide in the body resulting from ventilatory impairment.\nConcepts: MGCR1-PEN (Gene or Genome)\tSclerotome (Embryonic mesenchyme)\tFOETAL ALCOHOL SYNDROME (Psychological Disorders)\tRespiratory acidoses (Disorder of acid-base balance)\tFACT-C Version 4 - I Am Forced to Spend Time in Bed (FACT-C Version 4 Questionnaire Question)", + "output": "Respiratory acidoses (Disorder of acid-base balance)" + }, + { + "input": "Definition: Computer software described as computer database, software or program that aids medical personnel or patients in choosing the most appropriate diagnosis or therapy.\nConcepts: DIHYDRODIOL DEHYDROGENASE, TYPE I (Gene or Genome)\tMedical Decision Making, Computer-Assisted (Health Care Activity)\tregulation of positive chemotaxis to cAMP by chlorinated alkylphenone (regulation of positive chemotaxis to cAMP)\tNodular lesion (Finding)\tHealthcareProvider.roleCode (Intellectual Product)", + "output": "Medical Decision Making, Computer-Assisted (Health Care Activity)" + }, + { + "input": "Definition: Cell Function described as the controlled release of amylase from a cell of the pancreas.\nConcepts: pancreatic amylase secretion (amylase secretion)\tOncolytic Virus Therapy (Therapeutic or Preventive Procedure)\t(-)-N-(alpha-phenyl-beta-(4-tolyl)ethyl)linoleamide (Organic Chemical)\tEmergency care (basic management principles)\tC-terminal peptidyl-leucine amidation (peptidyl-leucine modification)", + "output": "pancreatic amylase secretion (amylase secretion)" + }, + { + "input": "Definition: Existing client in-office without ICD diagnosis described as assessing the health status of an existing massage therapy client in a usual, subsequent, 20-minute, in-office meeting to reevaluate and/or develop a treatment plan for somatic education, massage therapy and/or bodywork.\nConcepts: Usual subsequent 20 minutes in-office massage therapy intake (Health Care Activity)\tAortic aneurysm (Disease or Syndrome)\tDAD - Total Number of Applicable Items (DAD Questionnaire Question)\tETV6-MN1 Fusion Gene (Fusion Gene)\tNitroxinil (Anthelmintics)", + "output": "Usual subsequent 20 minutes in-office massage therapy intake (Health Care Activity)" + }, + { + "input": "Definition: Abnormality of red blood cells described as abnormally high mass or concentration of red blood cells in the blood, either due to an increase in erythropoiesis or a decrease in plasma volume.\nConcepts: Abnormally shaped erythrocytes (LABORATORY ABNORMALITIES)\tRSV Antigen (Immunologic Tests)\tHLA Class I Antibody (Laboratory Procedure)\tMK 7162 (Pharmacologic Substance)\tendpoints (Qualitative Concept)", + "output": "Abnormally shaped erythrocytes (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: something described as a rare epithelial tumor of the pancreas with histological characteristics of columnar, mucin-producing epithelium associated with ovarian-type subepithelial stroma, which does not communicate with the pancreatic ductal system, most frequently localized to the body or tail of the pancreas. Clinically, small tumors (less than 3 centimeters) are usually asymptomatic while large tumors typically present obstructive jaundice, a palpable abdominal mass, and may associate portal hypertension, hemobilia and diabetes mellitus.\nConcepts: DVC (Intellectual Product)\tHigh plasma glutamine (LABORATORY ABNORMALITIES)\tGlandular cell (General anatomical term)\tWall of right side of heart (Wall of cardiac chamber)\tMucinous Cystadencarcinoma of Pancreas (Cystadenocarcinoma of pancreas)", + "output": "Mucinous Cystadencarcinoma of Pancreas (Cystadenocarcinoma of pancreas)" + }, + { + "input": "Definition: Transcription factor genes described as this gene plays a role in epidermal differentiation.\nConcepts: Fitzpatrick Skin Phototype III (Fitzpatrick Classification Scale)\tNodular Lymphoid Hyperplasia of Lung (Lung diseases)\tZfp750 (Transcription factor genes)\tPQL1824 (Intellectual Product)\tintegrin alpha6-beta1 complex (integrin complex)", + "output": "Zfp750 (Transcription factor genes)" + }, + { + "input": "Definition: regulation of developmental process described as any process that modulates the frequency, rate or extent of epidermis development.\nConcepts: downregulation of filamentous growth of a population of unicellular organisms (negative regulation of filamentous growth)\tAbnormal UDP-glucose 4-epimerase level (Abnormal enzyme/coenzyme activity)\tregulation of epidermal development (Organ or Tissue Function)\t13q34 (Cell Component)\tresponse to linoleate (Cell Function)", + "output": "regulation of epidermal development (Organ or Tissue Function)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) How would you describe your respiratory condition?\nConcepts: negative regulation of maintenance of centromeric meiotic sister chromatin cohesion (negative regulation of maintenance of meiotic sister chromatid cohesion)\tGeminin (Cell Cycle Proteins)\tSGRQ0210 (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)\tNHL-BFM-90 Regimen (Therapeutic or Preventive Procedure)\tMethods, Feeding (Methods)", + "output": "SGRQ0210 (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)" + }, + { + "input": "Definition: something described as encephalopathy that is characterized by tiny holes apparent by microscopy, often due to prion disease.\nConcepts: Liver Cell Carcinoma pT0 TNM Finding v8 (Finding)\tresponse to 3-methylcholanthrene (Cell Function)\tCONTROLS FOR BLOOD-GASES, (Medical Device)\tspongiform encephalopathy (Central Nervous System Infection)\tazospermia (Genital Diseases, Male)", + "output": "spongiform encephalopathy (Central Nervous System Infection)" + }, + { + "input": "Definition: something described as administration of a drug directly upon the larynx.\nConcepts: nictitating membrane reflex (Physiologic Function)\tRumination (Mental Process)\tPQL1512 (Intellectual Product)\tNostrums (Pharmacologic Substance)\tLARYN (Functional Concept)", + "output": "LARYN (Functional Concept)" + }, + { + "input": "Definition: something described as c-C motif chemokine 1 (96 aa, ~11 kDa) is encoded by the human CCL1 gene. This protein is involved in monocyte chemotaxis.\nConcepts: infectious disease - clinical sepsis (Clinical infection)\tTCA3 protein, human (Immunologic Factor)\tTruncus arteriosus of foetus (Embryonic Structures)\tAbnormal morphology of right ventricular trabeculae (Abnormal morphology of myocardial trabeculae)\tDIXDC1 (Gene or Genome)", + "output": "TCA3 protein, human (Immunologic Factor)" + }, + { + "input": "Definition: something described as small airway (e.g., BRONCHIOLES) remodeling due to smoking, inhaled irritants, etc.\nConcepts: No History of Rheumatic Fever (Medical History)\tAdrenarche (Puberty stage - finding)\tAirway Remodeling, Small (Finding)\tubiquitin-like protein transferase activity (transferase activity)\tYMRS Questionnaire Question (Intellectual Product)", + "output": "Airway Remodeling, Small (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in leukemia.\nConcepts: Receptors, Discoidin Domain (Amino Acid, Peptide, or Protein)\tSubject Age (Age)\tFAC017-I Am Losing Weight (FACT-LEU Version 4 Questionnaire Question)\tCLLU1 (Gene or Genome)\tGrade 3 Chylothorax (Finding)", + "output": "CLLU1 (Gene or Genome)" + }, + { + "input": "Definition: something described as the expansion of a CD4-positive, alpha-beta T cell population by cell division.\nConcepts: Digital Data Copiers, Compact/Digital Versatile Disk (Digital Data Copiers)\tsiderophores (Iron Chelating Agents)\tPlasma Cell Myeloma by ISS Stage (Neoplastic Process)\tCD4-positive, alpha-beta T cell proliferation (alpha-beta T cell proliferation)\tHydroxytestosterones (testosterone)", + "output": "CD4-positive, alpha-beta T cell proliferation (alpha-beta T cell proliferation)" + }, + { + "input": "Definition: Immunologic Factor described as a dendritic cell (DC)-based cancer vaccine composed of autologous, type-1 polarized dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted HER-2-derived peptides, with potential immunomodulatory and antineoplastic activities. Autologous DCs were treated with GM-CSF, interleukin-4, interferon-gamma and bacterial lipopolysaccharide (LPS), a toll-like receptor type 4 agonist, to produce highly polarized DCs (alphaDC1) that are capable of producing high levels of interleukin-12p70 (IL-12p70). Upon administration, HER2-pulsed autologous DC vaccine may stimulate a potent cytotoxic T-lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by a variety of cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C114293\" active clinical trials using this agent.\nConcepts: Removal of verruca plantaris by occlusion using adhesive tape (Therapeutic or Preventive Procedure)\tCaspase 10 (Enzyme)\tHER-2 pulsed DC1 Vaccine (Pharmacologic Substance)\t15: 83724875-840-93590 (Spatial Concept)\tAlpha Fetoprotein Plasmid DNA Vaccine (Immunologic Factor)", + "output": "HER-2 pulsed DC1 Vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: Community special services assessment described as assessing a client/patient's need for meals to be delivered to his or her home.\nConcepts: Grade 1 Hypophysitis (Hypophysitis, CTCAE)\tPropyleneglycol (Synthetic polymer)\tGlycogen Synthase Kinase-3 Inhibitor 9-ING-41 (Organic Chemical)\tHAMDS1-Low Self-esteem and Guilt (Intellectual Product)\tMeals-on-Wheels assessment (Assessment regimes)", + "output": "Meals-on-Wheels assessment (Assessment regimes)" + }, + { + "input": "Definition: Colonic Ulcer, CTCAE 5 described as life-threatening consequences; urgent operative intervention indicated\nConcepts: Neonatal spontaneous intestinal perforation (Neonatal Adverse Event)\tMesangial abnormality (Anatomical Abnormality)\tserine family amino acid metabolic process (Molecular Function)\tCVD (Regimen Used to Treat Malignant Neuroendocrine and Adrenal Neoplasm)\tGrade 4 Colonic ulcer (Colonic Ulcer, CTCAE 5)", + "output": "Grade 4 Colonic ulcer (Colonic Ulcer, CTCAE 5)" + }, + { + "input": "Definition: Splint Device described as a noninvasive traction component is a device, such as a head halter, pelvic belt, or a traction splint, that does not penetrate the skin and is intended to assist in connecting a patient to a traction apparatus so that a therapeutic pulling force may be applied to the patient's body.\nConcepts: IFN binding (Molecular Function)\tEvaluates verification process for correct patient, procedure, site, side, and level surgery (Safety)\tInferior chorioretinal coloboma (Congenital Abnormality)\tDDS01-Subscale 6: Physician Distress (Intellectual Product)\tSPLINT, TRACTION (Medical Device)", + "output": "SPLINT, TRACTION (Medical Device)" + }, + { + "input": "Definition: something described as spine surgery retractors designed to temporarily separate and hold back the edges of a posterior lumbar incision, exposing and providing access to the lumbar vertebrae and surrounding anatomical structures. These retractors are handheld, manual instruments available in a variety of shapes and styles, usually including blunt distal blades and an integral handle and are selected according to the spinal procedure to be performed. Some lumbar retractors include two blades and scissor-like ratchet handles that permit the retractor to retain its position once it is set (i.e., self-retained retractors). Dedicated retractors intended to perform minimal-access lumbar (and lower thoracic) spinal surgery (e.g., including a split tube and expanding rails to permit appropriate opening and visualization) in procedures such as a microdiscectomy are also available.\nConcepts: ovaritis (Abnormal ovarian morphology)\tLate syphilis (Treponemal Infections)\t2,5-dimethoxy-4-methylamphetamine (Substituted amphetamine)\tGOSE - Work: How Restricted Are They (Intellectual Product)\tLumbar Spine Surgery Retractors (Medical Device)", + "output": "Lumbar Spine Surgery Retractors (Medical Device)" + }, + { + "input": "Definition: Pharmacologic Substance described as an angiopoietin that is closely related to ANGIOPOIETIN-1. It binds to the TIE-2 RECEPTOR without receptor stimulation and antagonizes the effect of ANGIOPOIETIN-1. However its antagonistic effect may be limited to cell receptors that occur within the vasculature. Angiopoietin-2 may therefore play a role in down-regulation of BLOOD VESSEL branching and sprouting.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, LRPPRC (Medical Device)\tactivities therapy (Activity Component)\tANGIOPOIETIN 02 (Pharmacologic Substance)\tReduced Lifting Ability (Intellectual Product)\tRestart (Qualitative Concept)", + "output": "ANGIOPOIETIN 02 (Pharmacologic Substance)" + }, + { + "input": "Definition: establishment of cell polarity described as the specification and formation of anisotropic intracellular organization of an epithelial cell.\nConcepts: Diphtheria, cutaneous (Skin Diseases, Bacterial)\tmidazolam (Tranquilizing Agents)\tCD16-41BB-CD3zeta ACTR autologous T cells (therapeutic autologous lymphocytes)\testablishment of epithelial cell polarity (establishment of cell polarity)\tLocalization (Mental Process)", + "output": "establishment of epithelial cell polarity (establishment of cell polarity)" + }, + { + "input": "Definition: Left side of heart described as a cardiac valve located between the left atrium and ventricle.\nConcepts: hsa-mir-29b-2 (MicroRNA Gene)\tMitral valve structure (Entire heart valve)\tEvery Five Days (Intervals of days)\thomeo box A1 (HOXA@ gene cluster)\tActivating Non-V600 BRAF Mutation (Cell or Molecular Dysfunction)", + "output": "Mitral valve structure (Entire heart valve)" + }, + { + "input": "Definition: Proximal pancreatectomy described as surgical removal of part of the pancreas, duodenum, and distal part of the bile duct. Sometimes, the lower portion of the stomach and the gallbladder are also removed. This procedure is performed for pancreatic, ampullary, duodenal and distal bile duct cancers.\nConcepts: cell autolysis (Apoptosis)\tpancreatoduodenectomy (Therapeutic or Preventive Procedure)\tatrial fibrillation chronic (Atrial fibrillation and flutter)\tGerardia pedicularis / American foxglove / fever weed (Western herbs and natural substances letter G)\tFluorphenazine (Phenothiazine [EPC])", + "output": "pancreatoduodenectomy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Prosthesis described as artificial substitute, constructed of either synthetic or biological material, which is used to partially or totally replace or repair injured or diseased joints.\nConcepts: Joint prosthesis (Medical Device)\tQuassinoid Agent (Organic Chemical)\tWas Regional Anesthesia Administered (CPTAC Questions)\tMIRN326 (MIR326 gene)\tExostoses of hand bones (Anatomical Abnormality)", + "output": "Joint prosthesis (Medical Device)" + }, + { + "input": "Definition: regulation of syncytial blastoderm mitotic cell cycle described as any process that activates or increases the rate or extent of progression through the syncytial blastoderm mitotic cell cycle.\nConcepts: upregulation of progression through syncytial blastoderm mitotic cell cycle (regulation of syncytial blastoderm mitotic cell cycle)\tMajor Axis Cross-sectional Diameter at Mid Ventricular Systole (Finding)\tStable Disease by Computed Tomography (Finding)\tAbnormal maternal serum screening (Finding)\tSsm4p ubiquitin ligase complex (ER ubiquitin ligase complex)", + "output": "upregulation of progression through syncytial blastoderm mitotic cell cycle (regulation of syncytial blastoderm mitotic cell cycle)" + }, + { + "input": "Definition: something described as catalysis of the reaction: hexadecanedioyl-CoA + sn-glycerol 3-phosphate <=> coenzyme A + sn-2-C16:0-DCA-LPA.\nConcepts: 10: 102880252-102887536 (Chromosome 10 Physical Location)\tsn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity (Molecular Function)\tremoval waxing (Procedures on External Ear)\tRNA RIBOSOMAL 28S (Ribosomal RNA)\tConcerned I would develop symptoms (Indication of)", + "output": "sn-2-glycerol-3-phosphate C16:0-DCA-CoA acyl transferase activity (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a painful hand deformity affecting the fingers. It is due to damage of the finger flexor tendons, causing the finger to remain in a locked position.\nConcepts: Impaired thrombin-induced platelet aggregation (Finding)\tRetrograde Amnesias (Other general symptoms)\tDigit, Trigger (Disorder of finger)\tcell growth in three dimensions (Cell Function)\tDibutyl phthalate-containing product (Plastics and glues patch test product)", + "output": "Digit, Trigger (Disorder of finger)" + }, + { + "input": "Definition: Intellectual Product described as the Movement Disorder Society version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Rigidity left lower extremity.\nConcepts: Mouse, Inbred BALB C (Mammal)\tGlycine dehydrogenase (Amino Acid Oxidoreductases)\tRheumatologic Disease (WHO Adverse Reaction Terminology)\tUPD2303E (Intellectual Product)\tresearch supported (Quantitative Concept)", + "output": "UPD2303E (Intellectual Product)" + }, + { + "input": "Definition: something described as a cell that forms the myelin sheath (a layer that covers and protects nerve cells) in the brain and spinal cord. An oligodendrocyte is a type of glial cell.\nConcepts: red tomato juice (Food)\tSulfotransferase Family 1C, Member 2 Gene (Gene or Genome)\tArgon-Enhanced Coagulation Electrosurgical Units (Medical Device)\tOligodendroglia Cell (Macroglia)\tFeel Slowed Down (Intellectual Product)", + "output": "Oligodendroglia Cell (Macroglia)" + }, + { + "input": "Definition: something described as a Kaposi sarcoma arising from the gallbladder.\nConcepts: Acute synovitis (Disease or Syndrome)\tRenal specialty enteral formula (Food)\tKaposi's Sarcoma of the Gallbladder (Kaposi Sarcoma)\tPlantar teleangiectasia (Telangiectasia of the skin)\tReviews Systematic as Topic (Intellectual Product)", + "output": "Kaposi's Sarcoma of the Gallbladder (Kaposi Sarcoma)" + }, + { + "input": "Definition: Molecular Function described as an aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized.\nConcepts: G Protein-Coupled Receptor Genes (Receptor Gene)\taerobic respiration, using sulphur or sulphate as electron donor (Cell Respiration)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Enzyme (IVD Test Reagent/Kits, Immunoassay, Tumor Marker)\tIncomplete Staging (Staging Incomplete)\tPowder and solvent for endosinusial solution (Biomedical or Dental Material)", + "output": "aerobic respiration, using sulphur or sulphate as electron donor (Cell Respiration)" + }, + { + "input": "Definition: something described as a response indicating that adjuvant post-operative targeted molecular therapy was administered.\nConcepts: Adjuvant Post-operative Targeted Molecular Therapy Was Administered (Finding)\tAgent, Fibrinolytic (Pharmacologic Substance)\tL/s ratio fetal lung (Chemical procedure)\t2 clinical phase trials (Research Activity)\tHow much has fatigue or lack of energy affected your satisfaction with your sex life (Clinical or Research Assessment Question)", + "output": "Adjuvant Post-operative Targeted Molecular Therapy Was Administered (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual can walk with verbal or physical help of one person and can move more than 50 yards.\nConcepts: Nanomole per Day (Quantitative Concept)\tH. pylori (Helicobacter species)\twalks with help of one person (verbal or physical) greater than 50 yards (Clinical or Research Assessment Answer)\trecurrent gestational trophoblastic tumor (stage, gestational trophoblastic tumor)\tsubthyroidism (cancer-related problem/condition)", + "output": "walks with help of one person (verbal or physical) greater than 50 yards (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as activities that include storing human prescription drug products prior to distribution to the points of dispensing.\nConcepts: L-type voltage-gated calcium channel complex location (voltage-gated calcium channel complex)\tWarehouse Human Prescription Drug Products (Storage)\tZinc Finger and SCAN Domain Containing 30 Gene (Transcription Regulation Gene)\tcellular response to phosphatidyl(amino)ethanols (response to phosphatidylethanolamine)\tPADGEM (Gene or Genome)", + "output": "Warehouse Human Prescription Drug Products (Storage)" + }, + { + "input": "Definition: something described as the lack of any bowel movements.\nConcepts: Absence of Bowel Movement (Finding)\tPeptostreptococcus (living organism) (Clostridiales)\tSolder Joint Fracture (Loss of or Failure to Bond)\tPrograms, Voluntary (Organization and Administration)\tIVD Test Reagent/Kits, Immunoassay, Lipoprotein (IVD Test Reagent/Kits, Immunoassay)", + "output": "Absence of Bowel Movement (Finding)" + }, + { + "input": "Definition: Deficiency of alveolar ridge described as vertical bone deficiency in the posterior region of alveolar ridge, which is a contributing factor to the development of a short vertical dimension of the face.\nConcepts: CHSF111 (CHART-SF Interview Version Questionnaire Question)\tCF-1 Mouse (Mammal)\tLEC-5 Standard Version - Transportation Accident: Job (Intellectual Product)\tcellular response to trehalose-6-phosphate stimulus (response to trehalose-6-phosphate)\tPosterior lower alveolar deficiency (Finding)", + "output": "Posterior lower alveolar deficiency (Finding)" + }, + { + "input": "Definition: something described as a component of the gastrointestinal tract of some reptiles (ALLIGATORS AND CROCODILES), as well as certain fish, mollusks, and insects. It functions to mechanically grind food.\nConcepts: translation factor (guanine nucleotide binding protein)\tNon-avian Gizzard (Body Part, Organ, or Organ Component)\tThick upper lip vermilion (Finding)\tResorbed or Dead Litter (Finding)\tquercetin 3'-O-glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "Non-avian Gizzard (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Immunoconjugates described as a fusion protein composed of a human leukocyte antigen (HLA) complex, HLA-A*0201, with a peptide epitope derived from the human papillomavirus type 16 (HPV16) E7 protein (amino acid residues 11-20), a reduced affinity human interleukin-2 (IL-2) variant, and an effector attenuated human immunoglobulin G1 (IgG1) Fc domain, with potential antineoplastic and immunostimulatory activities. Upon administration, CUE-101 targets and selectively binds to E7-specific CD8-positive T-cells present in patients with HPV16-driven malignancies. This may induce the secretion of inflammatory cytokines such as interferon gamma (IFN gamma) and promote the activation and expansion of tumor-specific CD8-positive cells, which may lead to T-cell-mediated elimination of tumor cells expressing the HPV16 E7 antigen. The HPV16 E7 oncoprotein is a cell surface glycoprotein and tumor-associated antigen (TAA) that is overexpressed in various HPV-associated cancers.\nConcepts: Anti-HPV16 E7 Fusion Protein CUE-101 (Amino Acid, Peptide, or Protein)\tCSS07-Most Recent Attempt Date (Intellectual Product)\tCarcinoma of the Lacrimal Gland pM1 TNM Finding v7 (Finding)\tHypoplasia of sella turcica (Skull)\tTired All the Time (Intellectual Product)", + "output": "Anti-HPV16 E7 Fusion Protein CUE-101 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Regimen Used to Treat Prostate Carcinoma described as a hormone therapy regimen consisting of histrelin that may be used in the treatment of prostate cancer.\nConcepts: 5'-3' exonucleolytic nuclear-transcribed mRNA catabolic process (Genetic Function)\tSignal Suppression (Imaging Techniques)\tTOMUZOTUXIMAB (Anti-EGFR Monoclonal Antibody)\tVantas Regimen (Therapeutic or Preventive Procedure)\tCIDOXEPIN HYDROCHLORIDE (Tricyclic Antidepressive Agents)", + "output": "Vantas Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a rare tumour of cranial and spinal nerves arising from peripheral nerve sheath and composed exclusively or predominantly of cells showing perineurial differentiation. It presents as a localised, tubular or fusiform enlargement of a nerve or nerve segment, usually in the extremities or the trunk, associated with a motor-predominant mononeuropathy including slow, painless, gradual loss of motor function in the involved nerve trunk with muscle weakness and atrophy and, rarely, sensory dysfunction. Cranial nerve involvement is rare.\nConcepts: Intraneural Perineurioma (Neoplastic Process)\tPP13187 (Gene or Genome)\tJO1AB (LABORATORY IMMUNOLOGIC PROCEDURES)\tdetection of dietary excess (Organism Function)\tStage IV Diffuse Mixed Cell Lymphoma (Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma)", + "output": "Intraneural Perineurioma (Neoplastic Process)" + }, + { + "input": "Definition: Finding described as a disorder characterized by a sensation of marked discomfort in the penis.\nConcepts: Cutaneous Squamous Cell Carcinoma of the Head and Neck cN2c TNM Finding v8 (Cutaneous Squamous Cell Carcinoma of the Head and Neck cN2 TNM Finding v8)\tPenile Pain, CTCAE 5 (Reproductive System and Breast Disorders, CTCAE)\tGlottic Carcinoma pT3 TNM Finding v8 (Glottic Cancer Pathologic Primary Tumor TNM Finding v8)\tStructure of iliacus muscle (Muscle of pelvic girdle)\tintermediate visual cortex (Body Part, Organ, or Organ Component)", + "output": "Penile Pain, CTCAE 5 (Reproductive System and Breast Disorders, CTCAE)" + }, + { + "input": "Definition: Physiological Effects of Drugs described as in medicine, a family of drugs used to treat depression, attention-deficit disorder (a common disorder in which children are inattentive, impulsive, and/or over-active), and narcolepsy (a sleep disorder that causes uncontrollable sleepiness). Stimulants increase brain activity, alertness, attention, and energy. They also raise blood pressure and increase heart rate and breathing rate.\nConcepts: TIS granule (cytoplasmic ribonucleoprotein granule)\tCNS Stimulating Drugs (Medicinal product categorized by therapeutic role)\tEcotype (Organism Attribute)\tPuerperal psychosis NOS (mental and behavioral disorders associated with puerperium, not elsewhere classified)\tRepeat, Ankyrin (Protein Binding Motif)", + "output": "CNS Stimulating Drugs (Medicinal product categorized by therapeutic role)" + }, + { + "input": "Definition: something described as organ segment which is regional part of trachea. Examples: cervical segment of trachea, bifurcation of trachea.\nConcepts: SEMUSTINE (Organic Chemical)\tSegment of trachea (Segment of tracheobronchial tree)\tIllustrations, Book (Occupational Activity)\tregulation of renal albumin absorption (regulation of renal system process)\tHistiocytic reaction (Neoplastic Process)", + "output": "Segment of trachea (Segment of tracheobronchial tree)" + }, + { + "input": "Definition: spore-bearing structure development described as the process that leads to the development of ascus, a sac-like structure produced by fungi of the phylum Ascomycota (sac fungi) in which sexually produced spores (ascospores), usually four or eight in number, are formed.\nConcepts: Feeding environment distraction management (Nutrition environment management)\tCanaloplasty Exploratory Probes (Medical Device)\tnegative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation (peptidyl-threonine phosphorylation)\tRickettsial vaccine, NOS (Immunologic Factor)\tascus development (spore-bearing structure development)", + "output": "ascus development (spore-bearing structure development)" + }, + { + "input": "Definition: Education described as gaining admission to school, education; engaging in all school-related responsibilities and privileges; learning the course material, subjects and other curriculum requirements in a primary or secondary education programme, including attending school regularly; working cooperatively with other students, taking direction from teachers, organizing, studying and completing assigned tasks and projects, and advancing to other stages of education.\nConcepts: 46,XY partial gonadal dysgenesis (Congenital anomaly of endocrine gonad)\tPower of muscles in lower half of the body (Muscle power functions)\tSchool education (Educational Activity)\tNonmass-like Enhancement (Enhancing Lesion)\tDesvenlafaxine succinate (Antidepressive Agents)", + "output": "School education (Educational Activity)" + }, + { + "input": "Definition: Organism Function described as the process in which the anatomical structures of determinate inflorescences are generated and organized. A determinate inflorescence is one that can produce an undefined number of floral meristems.\nConcepts: Acute cutaneous wound (Injury or Poisoning)\tgermline cell cycle switching, mitotic to meiotic cell cycle (cell cycle switching, mitotic to meiotic cell cycle)\tindeterminate inflorescence morphogenesis (Organism Function)\tapoptosis involved in endocardial cushion morphogenesis (apoptotic process involved in heart morphogenesis)\tImplements thermoregulation measures (Multisystem procedure)", + "output": "indeterminate inflorescence morphogenesis (Organism Function)" + }, + { + "input": "Definition: primary aminoacid described as essential aminoacid necessary for optimal growth in infants and for maintenance of nitrogen equilibrium in adult humans.\nConcepts: (S)-2,6-Diaminohexanoic acid (Pharmacologic Substance)\tNeoplasm of Vagina (Neoplastic Process)\tnegative regulation of synaptic vesicle clustering (negative regulation of cellular process)\tEL (Enzyme)\tconsumer survey (Research Activity)", + "output": "(S)-2,6-Diaminohexanoic acid (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as a question about how short of breath an individual gets or got when sweeping or mopping.\nConcepts: Loss of myelinated fibers (Finding)\tDyspnea Severity Sweeping or Mopping (Intellectual Product)\th reflex (Peripheral neurophysiological finding)\tANTIGENS, HA (INCLUDING HA CONTROL), INFLUENZA VIRUS A, B, C (Immunologic Factor)\tup regulation of vascular smooth muscle cell proliferation (Cell Function)", + "output": "Dyspnea Severity Sweeping or Mopping (Intellectual Product)" + }, + { + "input": "Definition: Disease Laboratory Finding Qualifier described as exhibiting characteristics of independently proliferating cells, notably altered morphology, growth characteristics, and/or biochemical and molecular properties.\nConcepts: Product containing propantheline (Organic Chemical)\tNeoplastic (Qualitative Concept)\tObsessive Compulsive Personality (Psychological Disorders)\t3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin (Vitamin K Antagonist [EPC])\tBPI Short Form - Pain at its Worst in Last 24 Hours (BPI Short Form Questionnaire Question)", + "output": "Neoplastic (Qualitative Concept)" + }, + { + "input": "Definition: something described as pneumothorax occurring neonatally without traumatic injury to the chest or lung.\nConcepts: sinapate ester anabolism (phenol-containing compound biosynthetic process)\tSpontaneous neonatal pneumothorax (Spontaneous pneumothorax)\tGranulation, Other (Granulation procedure)\tQLES1-Felt Able to Make Decisions (Q-LES-Q Questionnaire Question)\tRequirement, Nutrition (Dietary requirement finding)", + "output": "Spontaneous neonatal pneumothorax (Spontaneous pneumothorax)" + }, + { + "input": "Definition: something described as human LGALS8 wild-type allele is located within 1q42-q43 and is approximately 31 kb in length. This allele, which encodes galectin-8 protein, plays a role is several diverse processes that hinge upon integrin-like cellular interactions such as development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis and RNA splicing.\nConcepts: Inferior Vermian Artery (Body Part, Organ, or Organ Component)\tLectin, Galactoside-Binding, Soluble, 8 (Galectin 8) wt Allele (Gene or Genome)\tKINETIN (Nucleic Acid, Nucleoside, or Nucleotide)\tplacenta accreta was observed (Obstetric Labor Complications)\tSleep deprivation triggered symptoms (Triggered by)", + "output": "Lectin, Galactoside-Binding, Soluble, 8 (Galectin 8) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (October 2002) - Long Last 7 Days Self-Administered Format - How much time did you usually spend on one of those days doing vigorous physical activities as part of your work?: minutes per day.\nConcepts: melibiase activity (Molecular Function)\tSchultze Mechanism (Finding During Childbirth Labor)\tConstruction and Extraction (Occupation or Discipline)\tuV (Unit of electrical potential difference)\tIPA03-Vigorous Work Minutes per Day (Intellectual Product)", + "output": "IPA03-Vigorous Work Minutes per Day (Intellectual Product)" + }, + { + "input": "Definition: gastrointestinal described as a congenital malformation characterized by the absence of a normal opening in a part of the intestine. It can occur either in the small or the large intestine.\nConcepts: Intestinal atresia (Disease or Syndrome)\tCytidine deaminase (Deaminase)\tVitis (Viteae)\tLee Lung Cancer 2011 Oncology Response Criteria (Intellectual Product)\tB-Cell CLL Protein (Signaling Protein)", + "output": "Intestinal atresia (Disease or Syndrome)" + }, + { + "input": "Definition: something described as heterocyclic compounds that contain 4H,5H,6H,7H-thieno[2,3-c]pyridine as part of their structure.\nConcepts: Diatrizoate Meglumine (Organic Chemical)\tProduct containing ixabepilone (Nitrogen and nitrogen compound)\tMetalloproteinase 8, Matrix (Hydrolase)\tregulation of iron-sulfur cluster assembly (regulation of sulfur metabolic process)\tPlatelet ADP Receptor Antagonist (Organic Chemical)", + "output": "Platelet ADP Receptor Antagonist (Organic Chemical)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene plays a role in DNA recognition and repair.\nConcepts: Pathology Slide Computer-Aided Analyzers (Medical Device)\tAPURINIC/APYRIMIDINIC ENDONUCLEASE LIKE-2 (DNA Repair Gene)\tDisposable Bag Culture Biosynthesis (Laboratory Procedure)\ttRNA transcription from Pol III promoter (transcription by RNA polymerase III)\tNigra Compactas, Substantia (Subdivision of substantia nigra)", + "output": "APURINIC/APYRIMIDINIC ENDONUCLEASE LIKE-2 (DNA Repair Gene)" + }, + { + "input": "Definition: something described as a midday meal sometimes also called dinner.\nConcepts: Nucleic Acid Core Facility (Manufactured Object)\tPowder for extended-release suspension for injection (Powder for Suspension Dosage Form)\tGram per Cage per Week (Quantitative Concept)\tCD (Meal)\thDBP (Transport Protein Gene)", + "output": "CD (Meal)" + }, + { + "input": "Definition: Hereditary degenerative disease of central nervous system described as this syndrome is characterized by the association of a progressive leukodystrophy marked by generalized mental and motor impairment with the presence of thickened and wrinkled skin. It has been described in a Japanese brother and sister born to healthy parents. Both patients died in early childhood.\nConcepts: DERMATOLEUKODYSTROPHY (Leukodystrophy)\tMirror image dupliction of toes (Congenital Abnormality)\tIntratubular calcium oxalate casts (Finding)\tRefractory Lymphoblastic Lymphoma (Neoplastic Process)\tPIXANTRONE (Intercalating Agents)", + "output": "DERMATOLEUKODYSTROPHY (Leukodystrophy)" + }, + { + "input": "Definition: something described as the examination of a bone marrow sample using a histological staining method.\nConcepts: Nanoparticle-based Contrast Agent with Manganese SN132D (Organic Chemical)\tIFNA production (Organism Function)\tBone Marrow Staining (Laboratory Procedure)\tup-regulation of prolactin secretion (positive regulation of protein secretion)\tInpatient Visit (Encounter)", + "output": "Bone Marrow Staining (Laboratory Procedure)" + }, + { + "input": "Definition: Cancer Research Group described as a collaborative group formed in 1984 with members from Denmark, Finland, Iceland, Lithuania, Norway and Sweden and whose goal was to secure that all Nordic children suffering from leukemia would receive optimal therapy wherever they lived.\nConcepts: NOPHO (Health Care Related Organization)\tUlcerative Colitis-Associated Colorectal Adenocarcinoma (Neoplastic Process)\tcreatine transporter (Transport Protein Gene)\tCD34 wt Allele (CD34 gene)\tMASEQ (Sequence Number)", + "output": "NOPHO (Health Care Related Organization)" + }, + { + "input": "Definition: something described as this gene is involved in ligand-mediated transcriptional regulation.\nConcepts: PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA (Gene or Genome)\tPipette Fillers (In Vitro Diagnostics and Laboratory Equipment)\tAnatomical zone (General anatomical term)\tADCOFF05 (Intellectual Product)\tI am forced to spend time in bed (Findings-Based Question)", + "output": "PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-ALPHA (Gene or Genome)" + }, + { + "input": "Definition: Hereditary disorder of the integument described as autosomal dominant, congenital disorder characterized by localized hypomelanosis of the skin and hair. The most familiar feature is a white forelock presenting in 80 to 90 percent of the patients. The underlying defect is possibly related to the differentiation and migration of melanoblasts, as well as to defective development of the neural crest (neurocristopathy). Piebaldism may be closely related to WAARDENBURG SYNDROME.\nConcepts: Gene-Modified Tumor Cell Vaccine Therapy (Therapeutic or Preventive Procedure)\tbacterial extracellular vesicle (Cell Component)\tsteroid metabolism gene (Genes, Regulator)\tIVD Panels, Human Genetics, Eye Disorder, Glaucoma, Open Angle (IVD Panels, Human Genetics, Eye Disorder, Glaucoma)\tPiebald Trait (Congenital deficiency of pigment of skin)", + "output": "Piebald Trait (Congenital deficiency of pigment of skin)" + }, + { + "input": "Definition: Cycloparaffins described as seven-carbon cycloparaffin cycloheptane (the structural formula (CH2)7) and its derivatives.\nConcepts: Loss of Mismatch DNA Repair Protein MLH1 Expression (Protein Deregulation)\tCycloheptanes (Organic Chemical)\tNephropathy, deafness, hyperparathyroidism syndrome (Congenital hearing disorder)\tlycopenes (Carotene)\tCommittee, Advisory (Policy Making)", + "output": "Cycloheptanes (Organic Chemical)" + }, + { + "input": "Definition: Professional or Occupational Group described as an individual who is trained and qualified to perform pulmonary diagnostic tests. In the course of conducting these tests, the Pulmonary Function Technologist is able to setup, calibrate, maintain, and ensure the quality assurance of the pulmonary function testing equipment. In the laboratory, clinical or patient care setting the technologist instructs patients, elicits cooperation, performs procedures, monitors patient response, and evaluates patient performance. Tests results are calculated, compared with predicted normal ranges, and evaluated for reliability. The technologist collects clinical history data and evaluates the clinical implications of the test results.\nConcepts: language (Language spoken)\tAnti-MUC16 x Anti-CD3 REGN4018 (Immunologic Factor)\tcellular response to isooctane (cellular response to alkane)\t\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; \"Respiratory Therapist, Registered\", Pulmonary Function Technologist (Professional or Occupational Group)\tAmnesic syndrome due to alcohol (Psychoactive substance-induced organic mental disorder)", + "output": "\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; \"Respiratory Therapist, Registered\", Pulmonary Function Technologist (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as an acute diarrheal illness caused by consuming water or food contaminated by the bacterium Vibrio cholerae. Adequate rehydration is key to surviving this illness.\nConcepts: positive regulation of ribosomal DNA heterochromatin assembly (positive regulation of heterochromatin assembly)\tcellular response to purvalanol A (Cell Function)\tFifth metacarpal with ulnar notch (Hand)\tCholera vaccine (Vaccines and Antiserums)\tpN0(mol+) Breast Carcinoma v6 (Finding)", + "output": "Cholera vaccine (Vaccines and Antiserums)" + }, + { + "input": "Definition: Transient Receptor Potential Channels described as a highly conserved, non-selective TRP cation channel that contains 14-17 ANKYRIN REPEATS. It functions in cold sensation and NOCICEPTION of endogenous inflammatory factors and volatile irritants. TRPA1 is also activated by CANNABINOIDS and may play a role in sound perception by hair cells of the inner ear.\nConcepts: Channel, TRPA1 (Amino Acid, Peptide, or Protein)\tsaccharopine dehydrogenase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tPseudohypertrophic Muscular Dystrophy (Disease or Syndrome)\tOroantral fistula (Paranasal Sinus Disorder)\tnitrogen catabolite repression of transcription (Genetic Function)", + "output": "Channel, TRPA1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - During the last week, has it been easy or hard for your child to: Climb one flight of stairs?\nConcepts: Mucinous Adenocarcinoma of Prostate (Neoplastic Process)\tcitrate carrier activity (Molecular Function)\tLECTIN, C-TYPE, SUPERFAMILY MEMBER 12 (Immunoprotein Gene)\tPQL02-Hard Explain Illness to People (Intellectual Product)\tPODCI Adolescent Parent-Reported Version - Climb One Flight of Stairs (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "PODCI Adolescent Parent-Reported Version - Climb One Flight of Stairs (PODCI Adolescent Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: something described as a congenital or acquired defect in the bile acid biosynthesis, resulting in progressive liver disease.\nConcepts: LYMPH NODE, ILEOCECOCOLIC (Experimental Organism Anatomical Concept)\tAdolescent age (Age)\tAurora- and Ipl1-like midbody-associated protein 1 (Enzyme)\tBile Acid Synthesis Defect (Disease or Syndrome)\tSpermatozoid DNA Fragmentation Determination Reagents (Medical Device)", + "output": "Bile Acid Synthesis Defect (Disease or Syndrome)" + }, + { + "input": "Definition: something described as combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein.\nConcepts: phosphoarginine metabolism (phosphagen metabolic process)\tContinuous with relation (Intellectual Product)\talpha1 adrenoceptor (Molecular Function)\tCESPID (Intellectual Product)\tCAT (Symptom Specific Assessment Tool)", + "output": "alpha1 adrenoceptor (Molecular Function)" + }, + { + "input": "Definition: something described as a species of PESTIVIRUS causing systemic infections (BOVINE VIRUS DIARRHEA-MUCOSAL DISEASE) in cattle and some other cloven-hoofed animals. There are several strains and two biotypes: cytopathic (rare) and non-cytopathic. Infections range from clinically inapparent to severe, but do not correlate with biotypes.\nConcepts: MCV increased (Finding)\tSalvia officinalis / sage essence (Pharmacologic Substance)\tBovine viral diarrhea virus 1 (Bovine Viral Diarrhea Viruses)\tadult development (Phenomenon or Process)\tLACTOBACILLUS CATENAFORMIS (Lactobacillus)", + "output": "Bovine viral diarrhea virus 1 (Bovine Viral Diarrhea Viruses)" + }, + { + "input": "Definition: Cell Differentiation process described as the process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell.\nConcepts: Joint inflammation (Vertebral column)\tBuspirone hydrochloride (Anti-Anxiety Agents)\tTesticular Plasmacytoma (Neoplastic Process)\tear polyp (Ear disorders NEC)\tplant epidermal cell differentiation (Cell Function)", + "output": "plant epidermal cell differentiation (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of phosphatidylinositol 5-phosphate.\nConcepts: SODIUM-GLUCOSE COTRANSPORTER, RENAL (Transport Protein Gene)\tIPA0226D (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tDecoy Receptor, Tumor Necrosis Factor (Biologically Active Substance)\tChildhood MALToma (Neoplastic Process)\tphosphatidylinositol 5-phosphate synthesis (Molecular Function)", + "output": "phosphatidylinositol 5-phosphate synthesis (Molecular Function)" + }, + { + "input": "Definition: Device Labeled for Single Use described as solvent material designed to remove adhesive tape or other adhesive-based products (e.g., bandages, dressings, ostomy wafers, etc.) and the associated adhesive residue from the skin or other surfaces. The solvent is typically packaged in various forms for application, e.g., spray bottles or pre-soaked pads or swabs.\nConcepts: response to interleukin-2 (Cell Function)\tupregulation of prostaglandin biosynthetic process (positive regulation of unsaturated fatty acid biosynthetic process)\tShort Umbilical Cord (examination of umbilical cord)\tLYS-CYS-ASN-THR-ALA-THR-CYS-ALA-THR-GLN-ARG-LEU-ALA-ASN-PHE-LEU-VAL-HIS-SER-SER-ASN-ASN-PHE-GLY-PRO-ILE-LEU-PRO-PRO-THR-ASN-VAL-GLY-SER-ASN-THR-TYR-NH2 (Amylin Analog [EPC])\tadhesive remover MISCELL EACH (Device Labeled for Single Use)", + "output": "adhesive remover MISCELL EACH (Device Labeled for Single Use)" + }, + { + "input": "Definition: something described as kurtzke Functional Systems Scores test code.\nConcepts: CDISC Questionnaire KFSS Test Code Terminology (CDISC Questionnaire Terminology)\tregulation of B-lymphocyte activation (Cell Function)\tmuguet (Female external genitalia structure)\tNuclear Medicine Study Software (Intellectual Product)\tMPAI1-Social Contact-Friends/Coworkers (MPAI-4 Questionnaire Question)", + "output": "CDISC Questionnaire KFSS Test Code Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Intellectual Product described as performance of the Upper Limb Module for DMD 2.0 (PUL 2.0) Picking up coins.\nConcepts: positive regulation of transcription from RNA polymerase II promoter in response to salt stress (Genetic Function)\tMLL/SEPT6 FUSION GENE (Fusion Gene)\tCase Study (Intellectual Product)\tPoorly Perfused (Cardiovascular finding)\tPUL02-Picking Up Coins (Intellectual Product)", + "output": "PUL02-Picking Up Coins (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as the process of synaptic transmission from a neuron to another neuron across a synapse.\nConcepts: DISH, TISSUE CULTURE (Medical Device)\tneuron-neuron synaptic transmission (chemical synaptic transmission)\tB-Ion (Specimen)\tCaproic Acid (saturated carboxylic acid)\tUnbearable Pain (Sign or Symptom)", + "output": "neuron-neuron synaptic transmission (chemical synaptic transmission)" + }, + { + "input": "Definition: something described as an antibody drug conjugate (ADC) composed of a monoclonal antibody that targets the tumor-associated antigen (TAA) AG7 and is linked, through a hydrophilic, self-immolative linker, to a proprietary cytotoxic payload, with potential antineoplastic activity. Upon administration of AbGn-107 the antibody moiety targets and binds to the AG7 antigen expressed on a variety of cancer cells. Upon binding and internalization, the linker is cleaved and the payload is released, binds to tubulin, inhibits tubulin polymerization and kills the AG7-expressing tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C133818\" active clinical trials using this agent.\nConcepts: Cone-shaped end part of the outermost bone of the ring finger (Abnormality of the epiphysis of the distal phalanx of the 4th finger)\tembryonic anatomical structure morphogenesis (Morphogenesis)\tspinal nucleus of the trigeminal, oral part, middle dorsomedial part, dorsal zone (Body Part, Organ, or Organ Component)\tanti-AG7 antibody drug conjugate AbGn-107 (Immunoconjugates)\t1,4-bis((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-anthracenedione (Organic Chemical)", + "output": "anti-AG7 antibody drug conjugate AbGn-107 (Immunoconjugates)" + }, + { + "input": "Definition: something described as any anomaly of the scalp, the skin an subcutaneous tissue of the head on which head hair grows.\nConcepts: negative reinforcement (Reinforcement of behavior)\tdendritic spine membrane (Synaptic Membranes)\tAbuse;drug(s) (Drug Dependence)\t3-hydroxy-2-naphthoate 2,3-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tAnomaly of scalp (Anatomical Abnormality)", + "output": "Anomaly of scalp (Anatomical Abnormality)" + }, + { + "input": "Definition: Mucosal Melanoma of the Head and Neck described as melanoma that arises from the mucosal surface of the nasal cavity and paranasal sinus.\nConcepts: Sinonasal Melanoma (Nasal Cavity and Paranasal Sinus Neoplasm)\tSPAAT 7 (Simplified Preoperative Assessment for Appendix Tumor Score)\tDislike of Extremity (Clinical or Research Assessment Answer)\tRAI (Heart)\tbeta 2 integrin biosynthesis (integrin biosynthetic process)", + "output": "Sinonasal Melanoma (Nasal Cavity and Paranasal Sinus Neoplasm)" + }, + { + "input": "Definition: something described as stage IVA includes: (T4a, N1-2, M0); (T4a, NX, M0); (T4b, N0-2, M0); (Any T, N3, M0). T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. NX: Regional lymph nodes cannot be assessed. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis.\nConcepts: pistil development (Biologic Function)\tStage IVA Esophageal Squamous Cell Cancer (Neoplastic Process)\tEarly ossification of capital femoral epiphyses (Abnormal epiphyseal ossification)\tListening (Purposeful sensory experiences)\tMetastatic Cervical Adenocarcinoma (Neoplastic Process)", + "output": "Stage IVA Esophageal Squamous Cell Cancer (Neoplastic Process)" + }, + { + "input": "Definition: something described as the cell differentiation process that results in commitment of a cell to become part of the mesoderm.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Gastrointestinal Hormone, Gastric Inhibitory Polypeptide (Medical Device)\tGrade 3 Cranial nerve infection (Cranial Nerve Infection, CTCAE)\tPharbitis nil (L.) Choisy, 1834 (Ipomoea)\tMetenolone-containing product (Therapeutic Steroid Hormone)\tmesoderm cell fate commitment (Organ or Tissue Function)", + "output": "mesoderm cell fate commitment (Organ or Tissue Function)" + }, + { + "input": "Definition: Neisseria described as a species of nonmotile, aerobic, catalase-negative, asaccharolytic, oxidase-positive, urea-negative, gram-negative coccobacillus bacterium in the family Neisseriaceae. It is found in the oral bacterial flora of the human pharynx and throat. In rare cases N. elongata is a causative agent of bacterial endocarditis.\nConcepts: Neisseria elongata Bovre and Holten 1970 (Gram-negative bacillus)\tClassical transposition of great vessels (Heart)\tshort stature (Congenital Abnormality)\tApproach Anatomic Site Directionality Code (Intellectual Product)\tguanosine tetraphosphate binding (anion binding)", + "output": "Neisseria elongata Bovre and Holten 1970 (Gram-negative bacillus)" + }, + { + "input": "Definition: P [Preparations] described as a cardiotonic glycoside isolated from Scilla maritima var. alba (Squill).\nConcepts: Advanced Hepatocellular Carcinoma (Metastatic hepatocellular carcinoma)\tactivating transcription factor (Biologically Active Substance)\tpositive regulation of interleukin-1 anabolism (positive regulation of interleukin-1 production)\tBufa-4,20,22-trienolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-14-hydroxy-, (3beta)- (Organic Chemical)\tNADPH:Fe3+-EDTA reductase activity (oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor)", + "output": "Bufa-4,20,22-trienolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-14-hydroxy-, (3beta)- (Organic Chemical)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.\nConcepts: SEX (CDISC SDTM Terminology)\tAbdominal guarding (Palpation of abdomen)\tCentralized Testing Filenote (Note)\tToll-like receptor 2 binding (Toll-like receptor binding)\tAntigen, NOS (Immunologic Factors)", + "output": "Toll-like receptor 2 binding (Toll-like receptor binding)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate.\nConcepts: DALOTUZUMAB (D [Preparations])\timmune cell chemotaxis during immune response (leukocyte migration involved in immune response)\torotate reductase (NADH) activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tregulation of amyloid fibril formation (regulation of protein metabolic process)\tbreast cancer metastasis suppressor 1 (Gene or Genome)", + "output": "orotate reductase (NADH) activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Laboratory Procedure described as a laboratory test to find and measure the amount of a specific substance.\nConcepts: Fatty kidney (Disease or Syndrome)\tskeleton facial (Face)\tAccuracy, Dimensional Measurement (Reproducibility of Results)\tGlottic Carcinoma pT3 TNM Finding v8 (Glottic Cancer Pathologic Primary Tumor TNM Finding v8)\tAssay technique (Mixed Category Laboratory Procedure)", + "output": "Assay technique (Mixed Category Laboratory Procedure)" + }, + { + "input": "Definition: Musculoskeletal disorders congenital NEC described as a rare, overgrowth disorder in which babies are large at birth and may develop low blood sugar. Other common symptoms are a large tongue, large internal organs, and defects of the abdominal wall near the navel. Beckwith-Wiedemann syndrome increases the risk of developing certain cancers, especially Wilms tumor.\nConcepts: Beckwith syndrome (Disorder of body wall and cavities)\thC2GnT-M (glycosyltransferase)\tSGRQ Past 4 Weeks Version - My Cough is Embarrassing in Public (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)\tFAC05210 (Intellectual Product)\tBipolar Neuron (Neurons)", + "output": "Beckwith syndrome (Disorder of body wall and cavities)" + }, + { + "input": "Definition: Organism Function described as functions of the maintenance of structural integrity of the joints.\nConcepts: lamina affixa of the lateral ventricle (Region of wall of lateral ventricle)\tStability of joint functions (Stability of joint functions)\ttRNA export from nucleus (ncRNA export from nucleus)\tNonanaplastic Renal Wilms Tumor (Neoplastic Process)\tinositol heptakisphosphate 6-kinase activity (Molecular Function)", + "output": "Stability of joint functions (Stability of joint functions)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic compound of the polyamine class of chemicals with potential antineoplastic activity. Natural endogenous polyamines bind to DNA and are involved in a number of cellular processes such as cell division, differentiation, and membrane function. SL11093 displaces these polyamines from their DNA binding sites, resulting in cessation of cell growth and cell death.\nConcepts: Cyclo(L-phenylalanyl-L-phenylalanyl-D-pipecolinyl-L-2-amino-8-oxo -9,10-epoxy - decanoyl) (Amino Acid, Peptide, or Protein)\tCannot see (Eye)\tStudyOversightAuthority (Organization)\tprogrammed cell death by necrosis (Apoptosis)\tPolyamine Analog SL11093 (Pharmacologic Substance)", + "output": "Polyamine Analog SL11093 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a protein encoded by the CLDN18 gene.\nConcepts: MAC-1 Gene Mutation (Cell or Molecular Dysfunction)\tTL-118 (Angiogenesis Inhibitors)\tFamily Coxiellaceae (Gram-Negative Aerobic Rods and Cocci)\toligosaccharide (Sugars)\tCLDN18 Gene Product (Amino Acid, Peptide, or Protein)", + "output": "CLDN18 Gene Product (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Topical Spray described as ointment formed at the time of administration from a liquid preparation in a pressurized container with a spray valve or in a container equipped with a spray pump.\nConcepts: SDTM-VRTEST (Intellectual Product)\tTopical Ointment Spray Dosage Form (Biomedical or Dental Material)\tbrachydactyly-dwarfism-hearing loss-microcephaly-mental retardation syndrome (Disease or Syndrome)\tHypopharyngeal Cancer pN2a TNM Finding v7 (Hypopharyngeal Cancer pN2 TNM Finding v7)\tregulation of myometrium contraction (regulation of smooth muscle contraction)", + "output": "Topical Ointment Spray Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as a benign or malignant, primary or metastatic neoplasm affecting the accessory urethral gland.\nConcepts: Impedance Converter (Manufactured Object)\tAvadomide Hydrochloride (Organic Chemical)\tAccessory Urethral Gland Neoplasm (Neoplastic Process)\tcanthaxanthin (Pharmacologic Substance)\tHEAT-SHOCK PROTEIN, 70-KD, 1B (Gene or Genome)", + "output": "Accessory Urethral Gland Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Binding described as free Radical Binding involves temporary interaction with chemically unstable and highly reactive molecules (free radicals) having an unsatisfied electron valence pair. Agents of tissue damage through exposure to radiation, environment chemicals, and aging, reactive free radicals stabilize themselves by appropriating an electron from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell.\nConcepts: ribes nigrum seed oil (Organic Chemical)\tTumor Cell Vaccine plus BCG (Tumor Cell Derivative Vaccine)\tAutologous MAGE-A4 C1032 TCR-modified T Cells (therapeutic autologous lymphocytes)\tGlottic Cancer Pathologic Primary Tumor TNM Finding v7 (Finding)\tFree Radical Binding (Molecular Function)", + "output": "Free Radical Binding (Molecular Function)" + }, + { + "input": "Definition: something described as a terminology for coding clinical information in relation to drug therapy, used throughout the WHO Program by member countries and around the world by pharmaceutical companies and clinical research organisations. It has been developed over more than thirty years to serve as a basis for rational coding of adverse reaction terms.\nConcepts: downregulation of lymphocyte mediated immunity (Physiologic Function)\tWHO Adverse Reaction Dictionary (CodeSystem)\tgracile fasciculus (Medulla oblongata tract)\tOrthopedic External Fixation Systems, Fracture (Orthopedic External Fixation Systems)\tSclerostomy, NOS (Anterior segment of eye incision)", + "output": "WHO Adverse Reaction Dictionary (CodeSystem)" + }, + { + "input": "Definition: Cell metabolism disorders NEC described as the process by which phagocytes engulf and digest microorganisms and cellular debris; an important defense against infection.\nConcepts: Testosterone Vaginal Cream (Therapeutic Testosterone)\tphagocytosis (Immune System Phenomena)\tFACT-LYM Version 4 - I Have Pain (Intellectual Product)\tADCT-601 (Pharmacologic Substance)\tcobalt-precorrin 5A acetaldehyde-lyase activity (lyase activity)", + "output": "phagocytosis (Immune System Phenomena)" + }, + { + "input": "Definition: something described as bromine.\nConcepts: Frustrated by Being Too Tired to Do Things (Intellectual Product)\tmalignant mixed germ cell tumor of testis (Mixed Germ Cell Tumor)\tOver the past seven days how often did you have nausea (Findings-Based Question)\tBromine, Homeopathic preparation (Pharmacologic Substance)\tSWE (Geographic Area)", + "output": "Bromine, Homeopathic preparation (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a mutual, positive relationship between two people such as a parent/caregiver and an infant/child.\nConcepts: Penicillium notatum IgG Antibody (Immunoglobulin measurement)\tDiterpenoid, Abietane (Organic Chemical)\tENZYMATIC, CARBON-DIOXIDE (Indicator, Reagent, or Diagnostic Aid)\tbonding/attachment (Finding)\tC4.4A (Gene or Genome)", + "output": "bonding/attachment (Finding)" + }, + { + "input": "Definition: Non-Neoplastic Thymus Disorder described as the sudden shrinking and/or complete disappearance of the thymus gland; this often happens as a response to a physiologic stressor, such as infection or malnutrition.\nConcepts: MMS206A (Intellectual Product)\tRefractory Laryngeal Throat Squamous Cell Cancer (Neoplastic Process)\tMGC5149 (Gene or Genome)\tAcute Thymic Involution (Non-Neoplastic Thymus Disorder)\tHow Often Problems with Sexual Interest or Activity (Intellectual Product)", + "output": "Acute Thymic Involution (Non-Neoplastic Thymus Disorder)" + }, + { + "input": "Definition: Region of Canada described as an island in the Atlantic Ocean, off the east coast of Canada, constituting with Labrador on the mainland, a province of Canada. The name describing a land just discovered was recorded by John Cabot in 1497.\nConcepts: Cutaneous Melanoma cN3c TNM Finding v8 (Finding)\tATP2A2 protein, human (Carrier Proteins)\tSPIROCHETE INFECT (Other spirochetal diseases)\tnewfoundland (Region of Canada)\tAccelerated Starvation (Ketotic hypoglycemia)", + "output": "newfoundland (Region of Canada)" + }, + { + "input": "Definition: Toll-Like Receptor Signaling Pathway described as any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response.\nConcepts: MyD88-independent TLR signaling pathway (Toll-Like Receptor Signaling Pathway)\taspergillus infections (Hyalohyphomycosis)\tClinical Neurophysiology - Physicians (Physicians; Physician/Osteopath)\tM5a leukemia, adult acute (Neoplastic Process)\tcellular response to acadesine (cellular response to organonitrogen compound)", + "output": "MyD88-independent TLR signaling pathway (Toll-Like Receptor Signaling Pathway)" + }, + { + "input": "Definition: Chondrogenic Neoplasm described as a locally aggressive or rarely metastasizing cartilaginous matrix-producing neoplasm characterized by the presence of neoplastic chondrocytes.\nConcepts: Acro-renal-uterine-mandibular syndrome (Congenital Abnormality)\tIntermediate Chondrogenic Neoplasm (Neoplastic Process)\tPlexus uterovaginalis (Autonomic plexus)\tBreast Cancer 1 c.5265 5266insC (BRCA1 gene mutation)\tKalaallit (Population Group)", + "output": "Intermediate Chondrogenic Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Gestational Trophoblastic Tumor Pathologic Primary Tumor TNM Finding v7 described as gestational trophoblastic tumor in which the primary tumor cannot be assessed.\nConcepts: High-Resistance Angioplasty Cautery Units, Electrothermal (Electrothermal Cautery Units, High-Resistance, Transcatheter)\tAGRT (Gene or Genome)\tNasal Nerve (Body Part, Organ, or Organ Component)\tGestational Trophoblastic Tumor pTX TNM Finding v7 (Finding)\tpeptide cross-linking via L-cystine (peptide cross-linking)", + "output": "Gestational Trophoblastic Tumor pTX TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Choroidal and Ciliary Body Melanoma pT3 TNM Finding v8 described as choroidal and ciliary body melanoma, tumor size category 3 with ciliary body involvement and extraocular extension 5 mm or less in largest diameter.\nConcepts: bacterial-type flagellum basal body, distal rod, P ring (Cell Component)\tTooth Enamel Color Charts (Intellectual Product)\tMaternally Acquired Immunities (Organism Function)\tProduct containing macitentan (Organic Chemical)\tChoroidal and Ciliary Body Melanoma pT3d TNM Finding v8 (Choroidal and Ciliary Body Melanoma pT3 TNM Finding v8)", + "output": "Choroidal and Ciliary Body Melanoma pT3d TNM Finding v8 (Choroidal and Ciliary Body Melanoma pT3 TNM Finding v8)" + }, + { + "input": "Definition: Activity described as a sterilization method that uses a disinfectant for a period of time to kill all microorganisms except small numbers of bacterial spores.\nConcepts: EF-5 (Pharmacologic Substance)\tHigh-level Disinfectant Sterilization (Sterilization for infection control)\tSpinocerebellar ataxia with axonal neuropathy type 1 (Ataxia, Spinocerebellar)\tpharmacy (DedicatedNonClinicalLocationRoleType)\tDisease of anus (Anorectal Diseases)", + "output": "High-level Disinfectant Sterilization (Sterilization for infection control)" + }, + { + "input": "Definition: Safety described as programs or activities for accident prevention in aquatic environments.\nConcepts: HYPERTENSION ARTERIAL (Non-Cancer Diagnosis)\tMild neurosensory hearing loss (Mild hearing impairment)\tVENOUS SINUS (head vessels)\twater safety (Knowledge level: personal safety)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, LGMD2B (Medical Device)", + "output": "water safety (Knowledge level: personal safety)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child) In the past one month, how much of a problem has this been for your child: My child's legs hurt.\nConcepts: cyanelle thylakoid membrane (Cell Component)\tPQL08-Legs Hurt (Intellectual Product)\tSaws, Surgical, Bone, Pneumatic, Reciprocating, Sternum (Saws, Surgical, Bone, Pneumatic, Reciprocating)\tLoss of fat tissue in trunk (MUSCLE SOFT, TISSUE)\tPK (Physiologic Function)", + "output": "PQL08-Legs Hurt (Intellectual Product)" + }, + { + "input": "Definition: Abnormal P wave described as p wave below instead of above the baseline. P-wave inversion in the inferior leads may indicate a non-sinus origin of the P waves. []\nConcepts: WD4-Getting Dressed (Intellectual Product)\tErythrocyte macrocytosis (Hematopoietic system finding)\tregulation of hydrogen peroxide-mediated programmed cell death (regulation of programmed cell death)\tP wave inversion (Abnormal P wave)\tGallbladder (Gallbladder)", + "output": "P wave inversion (Abnormal P wave)" + }, + { + "input": "Definition: something described as blockage of the lumen of the pulmonary vein.\nConcepts: Magnaporthes (Ascomycota)\tStructure of myocardium of right ventricle (Body Part, Organ, or Organ Component)\tWnt receptor signalling pathway involved in digestive tract morphogenesis (Wnt Signaling Pathway)\tAgencies - Case Management (Health Care Related Organization)\tPulmonary vein obstruction (Cardiovascular finding)", + "output": "Pulmonary vein obstruction (Cardiovascular finding)" + }, + { + "input": "Definition: Conceptual Entity described as the confirmation (by other methods or modalities) that a tumor, which has not been previously seen or characterized, is present in the subject.\nConcepts: Cytotoxicities, Antibody-Dependent Cell (leukocyte mediated cytotoxicity)\tNew Tumor Confirmation (Conceptual Entity)\tCmax to Cmax Ratio Measurement (Pharmaceutical Product Characteristics)\tQuadriceps (Body Part, Organ, or Organ Component)\tEthanolamine Ammonia Lyase (Lyase)", + "output": "New Tumor Confirmation (Conceptual Entity)" + }, + { + "input": "Definition: something described as human ARHGEF5 wild-type allele is located within 7q33-q35 and is approximately 25 kb in length. This allele, which encodes Rho guanine nucleotide exchange factor 5 protein, plays a role in both Rho signal transduction and cytoskeletal organization.\nConcepts: 2,4-dichlorophenoxyacetic acid degradation (ether catabolic process)\tAnti-CD19/CD3 Tetravalent Antibody AFM11 (Pharmacologic Substance)\tStage III Extrahepatic Bile Duct Carcinoma (Neoplastic Process)\tentrepreneurship (Organizations & Organizational Behavior)\tARHGEF5 wt Allele (Gene or Genome)", + "output": "ARHGEF5 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Polypeptide Hormones described as a potent synthetic analog of GONADOTROPIN-RELEASING HORMONE with D-serine substitution at residue 6, glycine10 deletion, and other modifications.\nConcepts: (S)-(-)-carbidopa (Dopa decarboxylase inhibitor-containing product)\t6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Luteinizing Hormone-releasing Hormone Agonist)\tEuropean Union (Developed Countries)\tFollowing routines (Carrying out daily routine)\tForm FDA 1572 (Manufactured form)", + "output": "6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Luteinizing Hormone-releasing Hormone Agonist)" + }, + { + "input": "Definition: Mental Process described as process of reliving painful experiences and feelings, and the associated emotional responses.\nConcepts: fructose 6-phosphate aldolase activity (Molecular Function)\tCatharses (Mental Process)\tHistory Data Type (DataType)\tFamilial Hypotransferrinemia (Disease or Syndrome)\tSodium(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-Dioxide (sulbactam)", + "output": "Catharses (Mental Process)" + }, + { + "input": "Definition: Clinical Attribute described as a measurement of the occlusal plane to the Frankfort horizontal plane.\nConcepts: Lac vaccinum, cow milk, Homeopathic preparation (Homeopathic remedies letter L)\tCant of occlusal plane (Clinical Attribute)\tDiaminotoluene (Carcinogenic Aromatic Amine)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Cryptococcus Species (IVD Test Reagent/Kits, Serology, Fungi/Yeast)\tBisulfite reductase (Amino Acid, Peptide, or Protein)", + "output": "Cant of occlusal plane (Clinical Attribute)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a microorganism differentiation and identification device is a device intended for medical purposes that consists of one or more components, such as differential culture media, biochemical reagents, and paper discs or paper strips impregnated with test reagents, that are usually contained in individual compartments and used to differentiate and identify selected microorganisms. The device aids in the diagnosis of disease.\nConcepts: rnax educate about breast feeding (Intervention regimes)\tAbnormality of adrenal physiology (Pathologic Function)\tTEST,VAGINAL,BACTERIAL SIALIDASE (Indicator, Reagent, or Diagnostic Aid)\tbiohazard detection (evaluation/testing)\tETOFORMIN HYDROCHLORIDE (Pharmacologic Substance)", + "output": "TEST,VAGINAL,BACTERIAL SIALIDASE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: organic cation transmembrane transporter activity described as catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out).\nConcepts: metanephric glomerular endothelium development (metanephric glomerular epithelium development)\targinine-agmatine exchange transporter activity (Molecular Function)\tParaventricular nucleus of the hypothalamus, descending division (Body Part, Organ, or Organ Component)\tspine cancer (Central nervous system neoplasms malignant NEC)\tEntomobirnaviruses (Virus)", + "output": "arginine-agmatine exchange transporter activity (Molecular Function)" + }, + { + "input": "Definition: Implant-related action described as the act of fixing something firmly or setting something securely or deeply into the body.\nConcepts: pulmonary vein stenosis (Heart valve disease)\tCornus alternifolia / swamp walnut (Pharmacologic Substance)\timplant procedures (Operative Surgical Procedures)\thas-mir-105 (Nucleic Acid, Nucleoside, or Nucleotide)\tcarrier protein activity (Molecular Function)", + "output": "implant procedures (Operative Surgical Procedures)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the thymidylate synthetase (TYMS) gene, located at chromosome 18p11.32, which encodes the protein thymidylate synthase. Genetic variants at this locus have been associated with altered response to chemotherapy drugs.\nConcepts: Prophylactic treatment - intent (Thesaurus of Psychological Index Terms)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TYMS (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tExo-alpha-Sialidase (Amino Acid, Peptide, or Protein)\tBlood Chemical Analysis (Chemistry, Clinical)\tprimary miRNA methylation (primary miRNA modification)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TYMS (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Pharmacologic Substance described as a bacterial cell wall mimetic. It is a potent inducer of cytokines and is beginning Phase II trials in combination with chemotherapy for patients with non-small cell lung cancer.\nConcepts: 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity (Molecular Function)\tCyA 246 (Pharmacologic Substance)\tLC (Pontine structure)\tHemangiopericytoma, NOS (Neoplasm of perivascular myoid type - category)\tdown-regulation of nodal signaling pathway involved in determination of left/right asymmetry (negative regulation of nodal signaling pathway)", + "output": "CyA 246 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as disease that manifests either a quantitative or a qualitative defect of factor I\nConcepts: Septomarginal band (Set of organ components of heart)\tFactor I deficiency disease (Disease or Syndrome)\tBluetongue infection (Disease or Syndrome)\tLead Placement (Orientation)\tStage IIIA Rectal Neuroendocrine Tumor AJCC v8 (Neoplastic Process)", + "output": "Factor I deficiency disease (Disease or Syndrome)" + }, + { + "input": "Definition: R [Preparations] described as the hydrochloride salt form of rolapitant, an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of SP with the NK1-receptor plays a key role in the induction of nausea and vomiting caused by emetogenic cancer chemotherapy. Compared to other NK1-receptor antagonists, rolapitant has both a more rapid onset of action and a much longer half-life. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97955\" active clinical trials using this agent.\nConcepts: Poorly Perfused (Cardiovascular finding)\tRolapitant hydrochloride (R [Preparations])\tendosulfan monooxygenase I activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\tSlight Chance of Dozing (Findings-Based Question)\tRearrangement of 10p12.3 (Cell or Molecular Dysfunction)", + "output": "Rolapitant hydrochloride (R [Preparations])" + }, + { + "input": "Definition: viral process described as a process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects.\nConcepts: Flavonols (Flavonoids)\tCarcinoembryonic antigen: (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tPlasmids (Genetic Structures)\tlysogenic commitment (viral process)\tNucleus Pulposus (Mucous connective tissue)", + "output": "lysogenic commitment (viral process)" + }, + { + "input": "Definition: Estrogen Antagonists described as the citrate salt of a nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species.\nConcepts: Set of periodontal ligaments (Tooth Components)\tAbnormality of the fingernails (Anatomical Abnormality)\tProduct containing toremifene citrate (toremifene)\tNucleus (Thesaurus of Psychological Index Terms)\tTEST, SCREENING, FOR D POSITIVE FETAL RBC'S (Medical Device)", + "output": "Product containing toremifene citrate (toremifene)" + }, + { + "input": "Definition: Spatial Concept described as physical location of GAS8_Gene\nConcepts: GRAFT VERSUS HOST DIS (Unspecified disorder of immune mechanism)\tER-Golgi intermediate compartment membrane (bounding membrane of organelle)\tWNT2B Gene (Gene or Genome)\tdownregulation of norepinephrine uptake (regulation of norepinephrine uptake)\t16: 88616509-88638880 (Chromosome 16 Physical Location)", + "output": "16: 88616509-88638880 (Chromosome 16 Physical Location)" + }, + { + "input": "Definition: something described as this gene is involved in histone demethylation and brain development.\nConcepts: KDM7A Gene (Gene or Genome)\tDENTITION (Head and Neck Part)\tDrop Solution Dosage Form (Solution Dosage Form)\talpha6-beta4 integrin-CD151 complex (plasma membrane protein complex)\tpotassium ion binding (Molecular Function)", + "output": "KDM7A Gene (Gene or Genome)" + }, + { + "input": "Definition: Databases, Factual described as databases devoted to knowledge about specific genes and gene products.\nConcepts: Genetic Data Banks (Intellectual Product)\tregulation of glutamate-cysteine ligase activity (Molecular Function)\tfatty acid derivative degradation (Molecular Function)\tAutologous-Cell Leukemia Vaccine (Autologous Tumor Cell Vaccine)\timidazole (Pharmacologic Substance)", + "output": "Genetic Data Banks (Intellectual Product)" + }, + { + "input": "Definition: Activity described as the displacement of activities or cognitive content from one area to another.\nConcepts: Transference (Activity)\tprimaryPurposeCode (Intellectual Product)\tUPD2-Left Toe Tapping (MDS-UPDRS Questionnaire Question)\tAcetylcholine Receptors (Amino Acid, Peptide, or Protein)\tLOCATION OF INTEREST (Location)", + "output": "Transference (Activity)" + }, + { + "input": "Definition: cell population proliferation described as the multiplication or reproduction of cells, resulting in the expansion of a cell population in the bone marrow.\nConcepts: transmembrane L-histidine transport from lysosomal lumen to cytosol (Cell Function)\tSexually Immature (Organism Attribute)\tbone marrow cell proliferation (Cell Function)\tNeuroscience and Neuropsychiatric Research (Research Activity)\tVascular Capacitance (Finding)", + "output": "bone marrow cell proliferation (Cell Function)" + }, + { + "input": "Definition: Neuromuscular procedure described as interruption of the conduction of impulses in peripheral nerves or nerve trunks by the injection of a local anesthetic solution.\nConcepts: Spinal block (Operative procedure on spine)\tNasal Nerve (Body Part, Organ, or Organ Component)\tMacro (Conceptual Entity)\t5-methylcytosine biosynthesis (aromatic compound biosynthetic process)\tEffective Regurgitant Orifice Area (cardiac ultrasound)", + "output": "Spinal block (Operative procedure on spine)" + }, + { + "input": "Definition: something described as symptom Impact Questionnaire (SIQR) Please rate your level of balance problems.\nConcepts: MICRO RNA 574 (Gene or Genome)\tSquamous cell carcinoma of exocrine pancreas (Squamous cell carcinoma)\tdermis structure (Dense irregular connective tissue)\tSIQR0120 (Intellectual Product)\tSpinal Disk Implant (Medical Device)", + "output": "SIQR0120 (Intellectual Product)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 12 + 24-Item Interviewer - In the past 30 days, how much difficulty did you have in: Moving around inside your home?\nConcepts: Dermatofibrosarcoma Protuberan, Fibrosarcomatous (Dermatofibrosarcoma Protuberans)\tDRG2 protein, human (Binding Proteins)\tCYRM (Intellectual Product)\tLOCDTH (Spatial Concept)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Moving Around Inside Your Home (Intellectual Product)", + "output": "WHODAS 2.0 12+24-item Version Interviewer-administered - Moving Around Inside Your Home (Intellectual Product)" + }, + { + "input": "Definition: something described as human IKBIP wild-type allele is located in the vicinity of 12q23.1 and is approximately 31 kb in length. This allele, which encodes inhibitor of nuclear factor kappa-B kinase-interacting protein, is involved in the promotion of apoptosis.\nConcepts: Lamin-A/C (Biologically Active Substance)\tIKBKB Interacting Protein wt Allele (Gene or Genome)\tCognitions (PHYSIOLOGICAL DOMAIN)\tdown-regulation of vernalization response (regulation of vernalization response)\tPeriodontium of maxillary secondary tooth (Body Part, Organ, or Organ Component)", + "output": "IKBKB Interacting Protein wt Allele (Gene or Genome)" + }, + { + "input": "Definition: monovalent inorganic cation transmembrane transporter activity described as enables the transfer of potassium ions (K+) from one side of a membrane to the other.\nConcepts: potassium transporter activity (metal ion transmembrane transporter activity)\tPerformedObservationResult.valueNullFlavorReason (Idea or Concept)\tSURG REVISION (Surgical Procedure by Type)\tAPCH116 (APACHE II Clinical Classification Question)\tStage III Adult Diffuse Small Non-Cleaved Cell Lymphoma (Neoplastic Process)", + "output": "potassium transporter activity (metal ion transmembrane transporter activity)" + }, + { + "input": "Definition: Finding described as any abnormality in the proportion of CD8 T cells relative to the total number of T cells. []\nConcepts: Anticachexia Agent MT-102 (Pharmacologic Substance)\tAbnormal proportion of CD8+ T cells (Finding)\tClient Computer (Manufactured Object)\tCapsule Dose Form Category (Biomedical or Dental Material)\tLower anterior face height (Clinical Attribute)", + "output": "Abnormal proportion of CD8+ T cells (Finding)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify variants in the majority of genes known to be associated with pulmonary disorders, a collection of disorders affecting the structure and/or function of the lungs. Genetic variants at multiple loci have been associated with pulmonary disorders. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in the majority of pulmonary disorder-associated loci simultaneously.\nConcepts: Radial Growth Phase (Finding)\tParalysis, Sleep (Parasomnia)\tsabarubicin (Anthracycline Antibiotics)\tZinc Cation (Element, Ion, or Isotope)\tComprehensive Pulmonary Disorder Gene Panel Reagents (Medical Device)", + "output": "Comprehensive Pulmonary Disorder Gene Panel Reagents (Medical Device)" + }, + { + "input": "Definition: something described as acronym for a number of attributes or dimensions included in ALCOA, plus the following: Complete, Consistent, Enduring, and Available when needed. NOTE: ALCOA + is a recent way to summarily refer to the attributes or dimensions of data integrity.) After EMA Reflection Paper on eSOURCE in effect since 2010. See also WHO Annex V, Guidance on Good Data and Record Management Practices. See also ALCOA, data integrity.\nConcepts: Childhood Yolk Sac Neoplasm (Childhood Nongerminomatous Germ Cell Tumor)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Immunosuppressant, Tacrolimus (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Immunosuppressant)\tAttributable, Legible, Contemporaneous, Original, Accurate Plus (Intellectual Product)\tPleuroperitoneal membrane (Developmental membrane)\treferring (General Qualifier)", + "output": "Attributable, Legible, Contemporaneous, Original, Accurate Plus (Intellectual Product)" + }, + { + "input": "Definition: something described as fluid which has escaped from retinal blood vessels with a high concentration of lipid, protein, and cellular debris with a typically bright, reflective, white or cream colored appearance on the surface of the retina.\nConcepts: retinal exudates (Ocular vascular disorders NEC)\tAVL01-List A Recall 3 Word 9 (ADNI-AVLT Questionnaire Question)\tDarkening of skin around the mouth (Abnormal pigmentation)\tCRYOABLATION (surgical mechanism)\tdichotomous subdivision of terminal units involved in lung branching (dichotomous subdivision of an epithelial terminal unit)", + "output": "retinal exudates (Ocular vascular disorders NEC)" + }, + { + "input": "Definition: something described as assists with the insertion of central vascular access to administer IV fluids, medications, and blood products as ordered or for monitoring hemodynamics.\nConcepts: WNT10A Gene (WNT Family Gene)\tEstablishes central vascular access (Therapeutic or Preventive Procedure)\tComputer-Assisted Radiation Therapy (Therapy, Computer-Assisted)\tGolgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane (vesicle fusion with Golgi apparatus)\tup-regulation of long-day photoperiodism, flowering (regulation of long-day photoperiodism, flowering)", + "output": "Establishes central vascular access (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as the directed movement of a motile cell or organism away from the source of gravity.\nConcepts: no (Response)\tNottingham Grade 3 (Nottingham Grade)\tReviewable Unit Type Code (Intellectual Product)\tintercalated periaqueductal gray (Body Part, Organ, or Organ Component)\tnegative gravitactic behaviour (gravitaxis)", + "output": "negative gravitactic behaviour (gravitaxis)" + }, + { + "input": "Definition: Inclusion Bodies described as cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments.\nConcepts: Stage II Mixed Cellularity Classical Hodgkin Lymphoma (Neoplastic Process)\tIGF2BP3 (Biologically Active Substance)\tLewy body-like hyaline inclusion (Inclusion Bodies)\tSulfenic Acids (inorganic sulfur acid)\tD1F15S1A (MST1L gene)", + "output": "Lewy body-like hyaline inclusion (Inclusion Bodies)" + }, + { + "input": "Definition: Intellectual Product described as any one of several evaluation/assessment tools used to ascertain a patient's complaints with regard to his or her specific condition or diagnosis.\nConcepts: Clopidogrel-containing product (Antiplatelet Agents)\thost cellular process involved in virus induced gene silencing (Cell Function)\tSymptom-Specific Assessment Tool (Research or Clinical Assessment Tool)\tChoroidal and Ciliary Body Melanoma Pathologic Primary Tumor TNM Finding v8 (Uveal Melanoma Pathologic TNM Finding v8)\tRecombinant Beta Thromboglobulin (Amino Acid, Peptide, or Protein)", + "output": "Symptom-Specific Assessment Tool (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Governmental or Regulatory Activity described as the NIH is emphasizing the use of administrative supplements to attract underrepresented minorities into biomedical and behavioral research. Funds are available for administrative supplements to existing grants for the support and recruitment of underrepresented minority investigators and students. The aim of these supplements is to attract and encourage minority individuals to enter and pursue biomedical and behavioral research careers in areas within the missions of all the awarding components of the NIH by providing supplemental funds to certain ongoing research grants.\nConcepts: Bothnia retinal dystrophy (Disease or Syndrome)\tResearch Supplements for Underrepresented Minorities, Notice (Governmental or Regulatory Activity)\tFracture of metacarpus, NOS (Hand)\tlyases (Substance categorized by disposition)\tIntra-Ocular Injections (Intraocular Route of Drug Administration)", + "output": "Research Supplements for Underrepresented Minorities, Notice (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: something described as in the context of clinical outcomes, a comprehensive statement that fully and clearly describes and justifies the way a COA is to be used and the drug development-related purpose of the use. NOTE: The context of use defines the boundaries within which the available data adequately justify use of the COA and describes important criteria regarding the circumstances under which the COA is qualified.\nConcepts: membrane evagination (vesicle organization)\tLactobacillus johnsonii (Lactobacillus)\tIncrease in glutamine content of the diet compared to the assessed baseline intake of glutamine for the individual. (Glutamine modified diet)\tregulation of cell wall (1->3)-beta-D-glucan biosynthetic process (regulation of cellular component biogenesis)\tcontext of use (Description)", + "output": "context of use (Description)" + }, + { + "input": "Definition: CPTAC Responses described as a response that evidence of disease was not present after completion of therapy.\nConcepts: Cellulomonas turbata (Erikson 1954) Stackebrandt et al. 1983 (Cellulomonas)\tEvidence of Disease Absent after Completion of Therapy (Finding)\tdeterioration (Phenomenon or Process)\tChromatography Injectors (Injector)\tDetergent - cleaning agent (Detergents, Surfactants and Soaps)", + "output": "Evidence of Disease Absent after Completion of Therapy (Finding)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a molecular genetic abnormality indicating the presence of a mutation in exon 9 of the KIT gene located within 4q11-q12.\nConcepts: Abnormality of external carotid artery (Abnormal carotid artery morphology)\tKIT Proto-Oncogene Tyrosine Protein Kinase Gene Exon 9 Mutation (Cell or Molecular Dysfunction)\tpositive regulation of sulfur amino acid metabolism (regulation of sulfur amino acid metabolic process)\tAKN -028 (Pharmacologic Substance)\tPlace Cells (Pyramidal Cells)", + "output": "KIT Proto-Oncogene Tyrosine Protein Kinase Gene Exon 9 Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as the concurrent presence of three copies each of chromosomes 4 and 10.\nConcepts: Trisomy 4 and 10 (Cell or Molecular Dysfunction)\tcolposcopic biopsy (Biopsy)\tFibroblast Growth Factor Receptor Family Gene Amplification (Cell or Molecular Dysfunction)\toligosaccharide transport (carbohydrate transport)\t3-cym-5-yl methylcarbamate (Organic Chemical)", + "output": "Trisomy 4 and 10 (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Virus described as a strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.\nConcepts: Cytochrome P450 Family 1 (Cytochrome P450)\tpurine deoxyribonucleoside salvage (nucleoside salvage)\tFriend Murine Leukemia Virus (Murine leukemia virus)\tRegenerating Islet-Derived 3 Alpha wt Allele (Gene or Genome)\tHSPA4L gene (Chaperone Gene)", + "output": "Friend Murine Leukemia Virus (Murine leukemia virus)" + }, + { + "input": "Definition: something described as a questionnaire designed to measure key aspects of the delivery of primary care from the perspective of patients visiting their family physician, and to report the association of these aspects with patient satisfaction.\nConcepts: up regulation of autophagic cell death (positive regulation of programmed cell death)\tdownregulation of heparan sulfate binding (negative regulation of binding)\tComponents of Primary Care Instrument (Intellectual Product)\tMASEV (Qualitative Concept)\tmephenesin (Pharmacologic Substance)", + "output": "Components of Primary Care Instrument (Intellectual Product)" + }, + { + "input": "Definition: something described as a surgical procedure done largely for cosmetic reasons to correct receding chins, chin misalignment, or chin excess.\nConcepts: Scotoma, central (Scotoma, Central)\tELMO1 wt Allele (ELMO1 gene)\tANTISERA, FLUORESCENT, ALL GLOBULINS, PROTEUS SPP. (Indicator, Reagent, or Diagnostic Aid)\tRepositioning, Chin (Osteoplasty of mandible)\tTIM22 mitochondrial import inner membrane insertion complex (Cell Component)", + "output": "Repositioning, Chin (Osteoplasty of mandible)" + }, + { + "input": "Definition: Drug allergens described as a hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.\nConcepts: anti-FLT3 monoclonal antibody IMC-EB10 (Amino Acid, Peptide, or Protein)\tSimaroubaceae DC., 1811 (Angiosperm)\tORTHOSIS, SPINAL PEDICLE FIXATION, FOR DEGENERATIVE DISC DISEASE (Medical Device)\tProbability Sampling Method (Sampling Design)\tl asparaginase (Pharmacologic Substance)", + "output": "l asparaginase (Pharmacologic Substance)" + }, + { + "input": "Definition: Chromosome 19 Physical Location described as physical location of GLTSCR1_Gene\nConcepts: 19: 52874031-52898291 (Spatial Concept)\tReduction (Metabolism)\tCardiotachometers (Medical Device)\tHAMA - Fears (HAMA Questionnaire Question)\tPerformed Material Process Step Standard Time Indicator (Standard Time Indicator)", + "output": "19: 52874031-52898291 (Spatial Concept)" + }, + { + "input": "Definition: something described as human USF3 wild-type allele is located in the vicinity of 3q13.2 and is approximately 48 kb in length. This allele, which encodes basic helix-loop-helix domain-containing protein USF3, may be involved in transcription regulation.\nConcepts: CSS0212 (Intellectual Product)\tFallopian Tube Mucinous Metaplasia (Epithelial metaplasia)\tcalculus; salivary gland or duct (Calculi)\tKIAA2018 (Gene or Genome)\tWD2-Concentrating for Ten Minutes (Intellectual Product)", + "output": "KIAA2018 (Gene or Genome)" + }, + { + "input": "Definition: Abnormality of the proximal phalanx of the 3rd finger described as curved appearance of the proximal phalanx of the 3rd finger.\nConcepts: FAC100-Sev: Making a Bed Why Not (Intellectual Product)\tNeoplasms, Primary Brainstem (Central Nervous System Neoplasms, Primary)\tKappa Light Chain Restriction (Laboratory test result abnormal)\tCurved proximal phalanx of the 3rd finger (Anatomical Abnormality)\tSpecialist referral no charge (Adjunct care orders and/or referrals with or without ICD diagnosis)", + "output": "Curved proximal phalanx of the 3rd finger (Anatomical Abnormality)" + }, + { + "input": "Definition: Coordination Complexes described as manganese derivative of ethylenebisdithiocarbamate. It is used in agriculture as a fungicide and has been shown to cause irritation to the eyes, nose, skin, and throat.\nConcepts: Manganese, ((1,2-ethanediylbis(carbamodithioato))(2-))- (Medicinal product categorized by structure)\tRegio entorhinalis (Body Location or Region)\tHistone Cluster 1, H2AI Gene (Gene or Genome)\tdeoxyribonuclease (restriction endodeoxyribonuclease activity)\tPassers, Wire (Passer)", + "output": "Manganese, ((1,2-ethanediylbis(carbamodithioato))(2-))- (Medicinal product categorized by structure)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-folate receptor alpha (FRa; folate receptor 1; FOLR1) single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (CD3zeta; CD3z), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon administration, autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa are directed to and induce selective toxicity in FRa-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. FRa is overexpressed in various tumor cell types, and is associated with increased leukemic cell proliferation and aggressiveness. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity.\nConcepts: Stereotypies and motor perseveration (Organism Function)\tCSS05-Non-Spec Suicid Thought, Describe (C-SSRS Already Enrolled Subjects Questionnaire Question)\tIREL (Gene or Genome)\tProduct containing potassium nitrate (Nitrates)\tAutologous FRa-4SCAR-expressing T-cells 4SCAR-FRa (therapeutic autologous lymphocytes)", + "output": "Autologous FRa-4SCAR-expressing T-cells 4SCAR-FRa (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: Fusion protein described as a fusion protein encoded by the KIAA1549/BRAF fusion gene. This protein is comprised of half of the N-terminus of the putative UPF0606 protein KIAA1549 fused to the C-terminal half of the serine/threonine-protein kinase B-raf protein.\nConcepts: positive regulation of cytotoxic T cell granule exocytosis (Cell Function)\tregulation of metalloendopeptidase activity involved in APP catabolic process (Molecular Function)\tKIAA1549/BRAF Fusion Protein (Fusion protein)\tMaterials (Substance)\tperinuclear theca (Cell Component)", + "output": "KIAA1549/BRAF Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: something described as a type of clinical outcome assessment. A measurement based on a report that comes directly from the patient (i.e., study subject) about the status of a patient's health condition without amendment or interpretation of the patient's response by a clinician or anyone else. NOTE: A PRO can be measured by self-report or by interview provided that the interviewer records only the patient's response. Symptoms or other unobservable concepts known only to the patient can only be measured by PRO measures. PROs can also assess the patient perspective on functioning or activities that may also be observable by others.\nConcepts: Patient-Reported Outcome (Intellectual Product)\tAlarms, Foot Load (Alarm device)\tCoating, Roller (Laboratory Procedure)\tHeat Shock Protein 90 Inhibitor (Pharmacologic Substance)\tFAC07008 (Intellectual Product)", + "output": "Patient-Reported Outcome (Intellectual Product)" + }, + { + "input": "Definition: Peptic Ulcer described as an ulcerated lesion in the mucosal surface of the stomach. It may progress to involve the deeper layers of the gastric wall.\nConcepts: L-tyrosine phenol-lyase (carbon-carbon lyase activity)\tstomach; ulcer (gastric/duodenal)\tDietary Protocol (Treatment Protocols)\tpatient age at enrollment (Age)\tpeptide deformylase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)", + "output": "stomach; ulcer (gastric/duodenal)" + }, + { + "input": "Definition: Finding described as the method by which conception or impregnation is prevented. This may be achieved through the use of devices, drugs or surgery.\nConcepts: 2,4(1H,3H)-Pyrimidinedione, 5-beta-D-ribofuranosyl- (Nucleic Acid, Nucleoside, or Nucleotide)\tDICOM Derivation (Action)\tFreezers, Laboratory, Multiuse, Upright (Medical Device)\tp,p-sulphonylbisbenzenamine (Pharmacologic Substance)\tBCMETHOD (birth control)", + "output": "BCMETHOD (birth control)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as a form of diazoxide-sensitive diffuse hyperinsulinism caused by a lowered threshold for insulin release. Characterised by excessive/uncontrolled insulin secretion and recurrent episodes of profound hypoglycaemia induced by fasting and protein rich meals, requiring rapid and intensive treatment to prevent neurological sequelae. Activating mutations of GCK (7p15.3-p15.1) that encodes glucokinase have been identified as the cause.\nConcepts: ZNF750 wt Allele (ZNF750 gene)\tHyperinsulinism due to deficiency of glucokinase (Digestive system hereditary disorder)\tStudy Subject Radiography Report (Report)\tCyclophosphamide/Etoposide/Prednisone/Procarbazine Plus Rituximab (Regimen Used to Treat Non-Hodgkin Lymphoma)\tQLES161 (Q-LES-Q Questionnaire Question)", + "output": "Hyperinsulinism due to deficiency of glucokinase (Digestive system hereditary disorder)" + }, + { + "input": "Definition: Solid Dose Form described as solid sterile preparation consisting of a pliable piece of material impregnated or coated with a sealant or with a powder that forms a sealant after contact with an appropriate fluid (e.g. blood). It may act as a hemostatic agent and/or tissue glue. The matrix may itself form part of the seal, and is usually absorbed by the body over time.\nConcepts: Valine (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tThree of Four Patients Will Have Penile Erections Firm Enough to Have Sexual Intercourse After Surgery for Prostate Cancer (Intellectual Product)\tValvuloplasty (Plastic repair of unspecified valve of heart NOS)\tSealant matrix (Biomedical or Dental Material)\tGrade 2 Gastrointestinal Disorders - Other, Specify, CTCAE (Gastrointestinal Disorders - Other, Specify, CTCAE)", + "output": "Sealant matrix (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as physical location of CASP8_Gene\nConcepts: LDL Receptor Disorder (Disorder of lipid storage and metabolism)\tLinkage Analysis, Genetic (Molecular Analysis)\tNeoplasm of the anterior pituitary (Pituitary Neoplasms)\tImplantation Classification Supplemental Qualifiers Dataset (Intellectual Product)\t2: 201923719-201977938 (Chromosome 2 Physical Location)", + "output": "2: 201923719-201977938 (Chromosome 2 Physical Location)" + }, + { + "input": "Definition: Embryonic Structure described as a tissue layer of the early embryo comprised by the union of endoderm with splanchnic mesoderm, which ultimately forms the connective tissue and muscles of the digestive tube.\nConcepts: Potassium, Penicillin V (Antibiotic)\tSplanchnopleure (Embryonic Structure)\tSeastars (Sponges, Coelenterates and Echinoderms)\tUrethral Cancer by AJCC v7 Stage (Neoplastic Process)\tJuvenile Lesion (Lesion)", + "output": "Splanchnopleure (Embryonic Structure)" + }, + { + "input": "Definition: organic cyclic compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid.\nConcepts: quinate catabolism (Molecular Function)\tmiR-1246 (Nucleic Acid, Nucleoside, or Nucleotide)\tStrontium bromatum / strontium bromide (Inorganic Chemical)\tnegative regulation of type II hypersensitivity (Organism Function)\tMyopathy, Myofibrillar, Zasp-Related (Autosomal dominant hereditary disorder)", + "output": "quinate catabolism (Molecular Function)" + }, + { + "input": "Definition: Q [Preparations] described as quinine ascorbate is listed by USP as a smoking deterrent.\nConcepts: Mutation (Genetic Function)\tPerson (Polish translation of the Medical Subject Headings)\tQuinine product (Q [Preparations])\tVaginography (Imaging of genitourinary system)\tDORSOLATERAL (Anatomy Qualifier)", + "output": "Quinine product (Q [Preparations])" + }, + { + "input": "Definition: Genetic investigation procedure described as research conducted on related or non-related members of families, examining the affects of genetics, the environment, or twin offspring.\nConcepts: congenital heart disorder (Congenital vascular disorder)\tup-regulation of synaptic vesicle transport (positive regulation of transport)\tSubject Visit Start Day (Temporal Concept)\tFamily Based Study (Genetic investigation procedure)\tCore binding factor acute myeloid leukaemia (Acute myeloid leukemia with recurrent genetic abnormality)", + "output": "Family Based Study (Genetic investigation procedure)" + }, + { + "input": "Definition: Deidentification described as the process of protecting privacy that removes the association between the identifying data and the data subject. In anonymized data, the patient cannot be identified by the recipient of the information.\nConcepts: anonymization (Occupational Activity)\tPangolin (Mammals)\tLeft auricle wall (Body Part, Organ, or Organ Component)\tROSIGLITAZONE CHOLINATE (Thiazolidinedione Antidiabetic Agent)\tNKA (Protein or Enzyme Type Measurement)", + "output": "anonymization (Occupational Activity)" + }, + { + "input": "Definition: Euryarchaeota described as an order of extremely thermophilic, sulfate-reducing archaea, in the kingdom EURYARCHAEOTA. The single family Archaeoglobaceae contains one genus ARCHAEOGLOBUS.\nConcepts: Colorectal Cancer pNX TNM Finding v6 (Colorectal Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tGynecomastia (Reproductive System and Breast Disorders, CTCAE)\tLifts, Wheelchair, Vertical (Medical Device)\tFluoroscopy, NOS (Endoscopy)\tArchaeoglobales (CLASS ARCHAEOBACTERIA)", + "output": "Archaeoglobales (CLASS ARCHAEOBACTERIA)" + }, + { + "input": "Definition: Gene or Genome described as human KIR2DL3 wild-type allele is located in the vicinity of 19q13.4 and is approximately 15 kb in length. This allele, which encodes killer cell immunoglobulin-like receptor 2DL3 protein, plays a role in the regulation of the immune response.\nConcepts: positive regulation of auxin biosynthetic process (positive regulation of auxin metabolic process)\tAndersen cardiodysrhythmic periodic paralysis (Congenital heart disease)\tKiller Cell Immunoglobulin Like Receptor, Two Ig Domains and Long Cytoplasmic Tail 3 wt Allele (KIR2DL3 gene)\tAG 370 (Pharmacologic Substance)\tInterrogate, Difficult To (Failure to Interrogate)", + "output": "Killer Cell Immunoglobulin Like Receptor, Two Ig Domains and Long Cytoplasmic Tail 3 wt Allele (KIR2DL3 gene)" + }, + { + "input": "Definition: Myotonic Dystrophy described as a multisystemic disease characterized by the association of proximal muscle weakness with myotonia, cardiac manifestations and cataract. Patients usually present during adulthood. There are no reports of congenital or childhood onset but a rare juvenile form of the disease has been described. The disease is transmitted in an autosomal dominant manner and is caused by expansion of a CCTG repeat in intron 1 of the CNBP gene (3q21).\nConcepts: microfilament branch point (cellular anatomical entity)\testablishment of cell polarity involved in gastrulation cell migration (Cell Function)\tNegative Therapeutic Reaction (Psychotherapeutic Processes)\tConspecifics (Thesaurus of Psychological Index Terms)\tDYSTROPHIA MYOTONICA 2 (Autosomal dominant hereditary disorder)", + "output": "DYSTROPHIA MYOTONICA 2 (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: positive regulation of glial cell differentiation described as any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation.\nConcepts: isophenphos (Organic Chemical)\tCatheters, Nasopharyngeal, Oxygen Supply (Medical Device)\t/(s*kPa) (Unit of Lung Diffusion Capacity)\tV. posterior (Right posterior bronchopulmonary segment)\tup-regulation of oligodendrocyte differentiation (positive regulation of glial cell differentiation)", + "output": "up-regulation of oligodendrocyte differentiation (positive regulation of glial cell differentiation)" + }, + { + "input": "Definition: Fibroblast Growth Factor Gene Family described as this gene plays a role in neural development.\nConcepts: negative regulation of norepinephrine secretion (negative regulation of catecholamine secretion)\tLayer of CA1 field (Body Part, Organ, or Organ Component)\tCowdria ruminantium (Cowdry 1925) Moshkovski 1947 (canis group)\tMUC1 Peptide-Poly-ICLC Vaccine (Pharmacologic Substance)\tfibroblast growth factor 13 (Fibroblast Growth Factor Gene Family)", + "output": "fibroblast growth factor 13 (Fibroblast Growth Factor Gene Family)" + }, + { + "input": "Definition: Multi-Drug Resistance described as multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents.\nConcepts: fluid shift (Physiologic Function)\tPEGylation (Laboratory Procedure)\tFlurbiprofenum (Nonsteroidal Anti-inflammatory Drug [EPC])\tSR Record (Intellectual Product)\tMultidrug Resistance Inhibition (Cell Function)", + "output": "Multidrug Resistance Inhibition (Cell Function)" + }, + { + "input": "Definition: regulation of organ growth described as any process that modulates the rate, frequency, or extent of the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage.\nConcepts: regulation of growth plate cartilage chondrocyte differentiation (regulation of chondrocyte differentiation involved in endochondral bone morphogenesis)\tplasma cell neoplasm (blood/lymphatic neoplasm)\trRNA pseudouridine synthase activity (pseudouridine synthase activity)\tRacks, Filing, Large Document (Racks, Filing)\tnegative regulation of MyD88-dependent toll-like receptor signalling pathway (negative regulation of toll-like receptor signaling pathway)", + "output": "regulation of growth plate cartilage chondrocyte differentiation (regulation of chondrocyte differentiation involved in endochondral bone morphogenesis)" + }, + { + "input": "Definition: something described as a genus of tapeworms of the family Diphyllobothriidae, which are parasites of fish-eating cats, dogs, and birds. Infection in man is caused by eating undercooked fish. The larval form is called SPARGANUM.\nConcepts: Exercise-induced lactic acidemia (Acidosis, Lactic)\tGrade 1 Anosmia (Finding)\tSpirometra, NOS (Class Cestoda)\tmitotic actomyosin contractile ring contraction (Cell Function)\tStudy Outcome Measure Time Frame Text (Intellectual Product)", + "output": "Spirometra, NOS (Class Cestoda)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3 Toddler Parent Report - In the past one month, how much of a problem has this been for your child: My child takes a long time to eat.\nConcepts: At time of trough level (Finding)\tPQL09-Take Long Time to Eat (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)\tA65 ANTICOAGULANTS (Blood Products and Modifiers)\tZinc Finger and BTB Domain-Containing Protein 38 (Transcription Regulatory Protein)\tOxyphilic Endometrial Endometrioid Adenocarcinoma (Adenocarcinoma, Oxyphilic)", + "output": "PQL09-Take Long Time to Eat (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)" + }, + { + "input": "Definition: something described as the largest activity concentration occurring for a voxel within a volume of interest.\nConcepts: Apoptotic BCL2L1-Antisense Long Non-Coding RNA Gene (Apoptosis Regulation Gene)\tMEF2C wt Allele (Gene or Genome)\tSmall Cell Carcinoma of Breast (Extrapulmonary Small Cell Carcinoma)\tTumor status (Qualitative Concept)\tMaximum Voxel (Quantitative Concept)", + "output": "Maximum Voxel (Quantitative Concept)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as wall of ventricle which is continuous with the wall of pulmonary trunk.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PMM2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tTebi (Quantitative Concept)\tWall of right ventricle (Right ventricular structure)\tKeratitis;measles (Inflammatory abnormality of the eye)\targinine succinate synthetase activity (ligase activity, forming carbon-nitrogen bonds)", + "output": "Wall of right ventricle (Right ventricular structure)" + }, + { + "input": "Definition: something described as catalysis of the reaction: NAD(1-) + a sphinganine <=> 3-dehydrosphinganinium(1+) + NADH + H+.\nConcepts: LIM Domain-Binding Protein 2 (Transcription Regulatory Protein)\tPyrrolo-Iminoquinones (Indolequinones)\t3-ketodihydrosphinganine (C18) reductase activity (Molecular Function)\tStudy Research Coordinator (Study Personnel)\tELECTROPHORETIC, GLOBULIN (Medical Device)", + "output": "3-ketodihydrosphinganine (C18) reductase activity (Molecular Function)" + }, + { + "input": "Definition: Disorder of synovium described as non-neoplastic tumor-like lesions at joints, developed from the SYNOVIAL MEMBRANE of a joint through the JOINT CAPSULE into the periarticular tissues. They are filled with SYNOVIAL FLUID with a smooth and translucent appearance. A synovial cyst can develop from any joint, but most commonly at the back of the knee, where it is known as POPLITEAL CYST.\nConcepts: downregulation of de novo NAD biosynthetic process from tryptophan (regulation of 'de novo' NAD biosynthetic process from tryptophan)\tSynovial cyst unspecified (Skeletal)\tMalignant Tumor of the Inferior Vena Cava (Neoplastic Process)\tAnti-c-Met Monoclonal Antibody ARGX-111 (Anti-c-Met Monoclonal Antibody)\tSyndromes, Retinitis Pigmentosa-Deafness (Usher Syndrome)", + "output": "Synovial cyst unspecified (Skeletal)" + }, + { + "input": "Definition: Organic Chemical described as organic compound that contains carbon and hydrogen, with chlorine atoms substituting for one or more hydrogens.\nConcepts: regulation of shade avoidance (regulation of response to red or far red light)\tAlpha-carboxylase (Amino Acid, Peptide, or Protein)\tChlorinated hydrocarbon, NOS (Organic Chemicals)\tRecurrent Primary Amyloidosis (Neoplastic Process)\tcomputer (manufactured apparatus)", + "output": "Chlorinated hydrocarbon, NOS (Organic Chemicals)" + }, + { + "input": "Definition: something described as the first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments.\nConcepts: ERBB c.2572 2573CT>AA (Cell or Molecular Dysfunction)\tPEP-CMV vaccine (Amino Acid, Peptide, or Protein)\tisovaleryl-CoA(4-) synthesis (isovaleryl-CoA(4-) metabolic process)\tIsometric Exercise (Therapeutic or Preventive Procedure)\ti phase trials (Research Activity)", + "output": "i phase trials (Research Activity)" + }, + { + "input": "Definition: something described as instruments or technological means of communication that reach large numbers of people with a common message; includes press, radio, television, etc.\nConcepts: Anti-CD79a Antibody (Immunologic Factor)\tdown regulation of cellular response to heat stress (negative regulation of response to stimulus)\tmass information media (Computers & Media)\tPerforation of the colon (Injury of large intestine)\tregulation of TNF-beta production (Organism Function)", + "output": "mass information media (Computers & Media)" + }, + { + "input": "Definition: something described as the identifier AAML1031, assigned to a study in a clinical trial.\nConcepts: FACIT-F Version 4 - I Feel Close to My Friends (FACIT-F Version 4 Questionnaire Question)\tAAML1031 (Intellectual Product)\tlemnae seu spirodelae/fu pin (Plant)\tenhancement of host programmed cell death by organism (Organism Function)\tLog10 per Milliliter (Unit of Dose Calculation)", + "output": "AAML1031 (Intellectual Product)" + }, + { + "input": "Definition: something described as a standardized guideline developed by the Response Evaluation Criteria in Solid Tumors (RECIST) Working Group in 2000, which is an objective response criteria used to assess solid tumor response and to measure change in tumor size for use in adult and pediatric cancer clinical trials. RECIST version 1.0 contains the following key features: definitions of minimum size of measurable lesions, instructions on how many lesions to follow, and the use of uni-dimensional rather than bi-dimensional measures for evaluation of tumor burden.\nConcepts: Response Evaluation Criteria in Solid Tumors Version 1.0 (Intellectual Product)\tTRIO wt Allele (Gene or Genome)\tN-acetylindoxyl:oxygen oxidoreductase activity (Molecular Function)\tRecorders, Videonystagmography (Diagnostic Equipment, Ophthalmological)\tJIG, PISTON CUTTING, ENT, STERILE (Medical Device)", + "output": "Response Evaluation Criteria in Solid Tumors Version 1.0 (Intellectual Product)" + }, + { + "input": "Definition: Geographic Area described as second largest continent, after Asia, covering about one-fifth of the total land surface of the Earth; the continent is bounded on the west by the Atlantic Ocean, on the north by the Mediterranean Sea, on the east by the Red Sea and the Indian Ocean, and on the south by the mingling waters of the Atlantic and Indian oceans.\nConcepts: Africa (Geographic Area)\tLensometers, Manual (Medical Device)\tAntibody, Catalytic (Biologically Active Substance)\tregulation of protein adenylation (regulation of protein modification process)\tdiazepam level test (Laboratory Procedure)", + "output": "Africa (Geographic Area)" + }, + { + "input": "Definition: extracellular polysaccharide metabolic process described as the chemical reactions and pathways resulting in the breakdown of polysaccharides used in extracellular structures.\nConcepts: mitoguazone di-HCl (Pharmacologic Substance)\tCSS11-Most Severe Idea, Reasons-Life (C-SSRS Lifetime/Recent Version Questionnaire Question)\tacetylcholine secretion, neurotransmission (acetylcholine secretion)\tNational Nanotechnology Initiative Project Component Area 7 (Classification)\textracellular polysaccharide breakdown (cellular polysaccharide catabolic process)", + "output": "extracellular polysaccharide breakdown (cellular polysaccharide catabolic process)" + }, + { + "input": "Definition: something described as a family of low MOLECULAR WEIGHT actin-binding proteins found throughout eukaryotes. They remodel the actin CYTOSKELETON by severing ACTIN FILAMENTS and increasing the rate of monomer dissociation.\nConcepts: Advanced Bile Duct Carcinoma (Metastatic Bile Duct Carcinoma)\tFAC10073 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tCofilin Proteins (Biologically Active Substance)\tPTEN1 Gene Alteration Positive (PTEN Alteration Positive)\tseptin collar (septin cytoskeleton)", + "output": "Cofilin Proteins (Biologically Active Substance)" + }, + { + "input": "Definition: Liver Failure described as a constellation of signs and symptoms characterized by changes in personality, consciousness, and reflexes, resulting from neuropsychiatric abnormalities secondary to liver failure without evidence of other brain disease.\nConcepts: C-SSRS Since Last Visit - Suicide (Intellectual Product)\tStage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma (Ann Arbor Stage II Non-Contiguous Aggressive Adult Non-Hodgkin Lymphoma)\tencephalopathy hepatic (Liver diseases)\tCYP2C9, T299A (Gene or Genome)\tSelf-Management: Known Allergy (Finding)", + "output": "encephalopathy hepatic (Liver diseases)" + }, + { + "input": "Definition: phosphoric monoester hydrolase activity described as catalysis of the reaction: ribitol-5-phosphate + H20 = ribitol + phosphate.\nConcepts: HAWAIIAN (Polynesians)\tribitol-5-phosphatase activity (Molecular Function)\tbHLHc3 (TRANSCRIPTION FACTOR)\tparental attitudes (Qualitative Concept)\tDifferentiated and Anaplastic Thyroid Carcinoma pT4 TNM Finding v8 (Finding)", + "output": "ribitol-5-phosphatase activity (Molecular Function)" + }, + { + "input": "Definition: negative regulation of steroid hormone biosynthetic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.\nConcepts: Leydig cells (Epithelioid Cells)\tEnamel abnormality (Tooth structure)\tdown regulation of aldosterone biosynthetic process (negative regulation of alcohol biosynthetic process)\trF-PSA/PSMA/TRICOM (Recombinant Fowlpox-TRICOM Vaccine)\tprotein vacuolar targeting (establishment of protein localization to vacuole)", + "output": "down regulation of aldosterone biosynthetic process (negative regulation of alcohol biosynthetic process)" + }, + { + "input": "Definition: Diagnostic Procedure described as diagnostic tests performed on infants to assess overall health and identify potential areas of concern.\nConcepts: Was KRAS Mutation Analysis Performed (Intellectual Product)\thomotetrameric ADPG pyrophosphorylase complex location (ADPG pyrophosphorylase complex)\tInfant Screening (Age Appropriate Screening)\tHow Often Discuss or Consider Divorce, Separation or Terminating Relationship (Clinical or Research Assessment Question)\tClinical Stage IA Melanoma of the Skin AJCC v8 (Neoplastic Process)", + "output": "Infant Screening (Age Appropriate Screening)" + }, + { + "input": "Definition: Anatomical feature described as subdivision of viscerocranial mucosa behind the opening of the pharyngotympanic tube. Examples: There are only two instances, right and left salpingopharyngeal folds.\nConcepts: NRS 6-Point (Numeric Rating Scale)\tADTC01TC (CDISC Questionnaire Terminology)\tStructure of salpingopharyngeal fold (Body Location or Region)\tSegmentation (Part)\tRetinoblastoma cT1a TNM Finding v8 (Finding)", + "output": "Structure of salpingopharyngeal fold (Body Location or Region)" + }, + { + "input": "Definition: PHQ Screener Version Questionnaire Question described as patient Health Questionnaire Screener Version - Think about your last bad anxiety attack. Did you have hot flashes or chills?\nConcepts: Fiberoptic Cladding Device (Manufactured Object)\tPHQ0304F (PHQ Screener Version Questionnaire Question)\tacetate cellulose electrophoresis (Electrophoresis)\tDisproportionately large nose (HEENT)\tSet of areolar tubercles (Sebaceous Glands)", + "output": "PHQ0304F (PHQ Screener Version Questionnaire Question)" + }, + { + "input": "Definition: Erythrocyte Abnormalities, General and NEC described as the presence of erythrocytes that are sphere-shaped.\nConcepts: Tamoxifen Citrate Regimen (Therapeutic or Preventive Procedure)\tTWO-COLOR MICROARRAY (Microarray)\tDimer, Cyclobutane-Pyrimidine (Oligonucleotides)\tAudible Prompt/Feedback (Finding)\tSPHEROCYTOSIS (Red blood cell shape - finding)", + "output": "SPHEROCYTOSIS (Red blood cell shape - finding)" + }, + { + "input": "Definition: hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the reaction: H2O + scopolin <=> beta-D-glucose + scopoletin.\nConcepts: BRUCELLA MELITENSIS (Bacterium)\tscopolin beta-glucosidase activity (Molecular Function)\tConnarus (Plant)\tSEX (Personal Attribute)\tAnti-alpha5beta1 Integrin Monoclonal Antibody PF-04605412 (Angiogenesis Inhibitors)", + "output": "scopolin beta-glucosidase activity (Molecular Function)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as a form of syndromic craniosynostosis with characteristics of craniosynostosis, mild facial dysmorphism (prominent supraorbital ridges, mild proptosis and maxillary hypoplasia) and calcification of the basal ganglia. The disease is associated with a favorable neurological outcome, normal intelligence and is inherited in an autosomal recessive manner.\nConcepts: IDSR125 (Intellectual Product)\tMENINGOHYDROENCEPHALOCELE (Neural Tube Defects)\tCraniosynostosis and intracranial calcification syndrome (Anomalies of cerebrum)\tFibrosarcoma non-metastatic (Non-Metastatic Neoplasm)\tRotating Pan Coating Method (Drug Formulation Process)", + "output": "Craniosynostosis and intracranial calcification syndrome (Anomalies of cerebrum)" + }, + { + "input": "Definition: something described as absence or underdevelopment of a cranial sinus or sinuses.\nConcepts: Endotracheal Route of Drug Administration (Intravenous Route of Drug Administration)\tfistulas gastrointestinal (Disease or Syndrome)\tMPAI1-Irritablity, Anger, Aggression (MPAI-4 Questionnaire Question)\tEzatiostat Hydrochloride (Amino Acid, Peptide, or Protein)\tAplasia/Hypoplasia involving the sinuses (Anatomical Abnormality)", + "output": "Aplasia/Hypoplasia involving the sinuses (Anatomical Abnormality)" + }, + { + "input": "Definition: Stage IA Lung Non-Small Cell Carcinoma AJCC v7 described as stage IA2 includes: T1b, N0, M0. T1b: Tumor measuring more than 1 cm but 2 cm or less in greatest dimension. N0: No regional lymph node metastases. M0: No distant metastasis.\nConcepts: Plasmodium berghei (Plasmodium)\tStage IA2 Lung Cancer AJCC v8 (Stage I Lung Cancer AJCC v8)\tMYXOMA (Myxomatous neoplasm)\tEvery five hours (Temporal Concept)\tAbnormality of the atrial septum (Atrial cardiopathy)", + "output": "Stage IA2 Lung Cancer AJCC v8 (Stage I Lung Cancer AJCC v8)" + }, + { + "input": "Definition: something described as surgical removal of the fallopian tubes and ovaries.\nConcepts: oophorectomies salpingo (Ovarian ablation)\tPHQ-15 - Dizziness (Intellectual Product)\tDietary supplements (Food)\tCitrobacter freundii (Braak 1928) Werkman and Gillen 1932 (Bacterium)\tCDISC Questionnaire CGI Test Code Terminology (Intellectual Product)", + "output": "oophorectomies salpingo (Ovarian ablation)" + }, + { + "input": "Definition: something described as the progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart.\nConcepts: micelle (Organic Chemical)\tStandard weaning infant formula (Standard infant formula)\tcollagen breakdown (Catabolism)\theart fibrous skeleton development (connective tissue development)\tComprehensive prolonged subsequent 90 minute follow-up phone consult homeopathic intake (Phone conversations with or without ICD diagnosis)", + "output": "heart fibrous skeleton development (connective tissue development)" + }, + { + "input": "Definition: something described as a score of 34 on the COXEN Sensitivity Scale.\nConcepts: Abnormal urine colour, NOS (Abnormality of urine homeostasis)\t2-(4-tert-butyl-2,6-dimethyl-3-hydroxybenzyl)-2-imidazoline (Vasoconstrictor [EPC])\tCacao tree (Family Sterculiaceae)\tCalcyclin (Cell Cycle Proteins)\tCOXEN Score 34 (Finding)", + "output": "COXEN Score 34 (Finding)" + }, + { + "input": "Definition: Body Surface Area Formula described as the formula to calculate body surface area in cats. It is mathematically defined as: BSA (m^2) = (10.1 x Weight(g)^2/3)/1000\nConcepts: Hepatitis E Virus RNA (Microbiology procedure)\tBSA Formula for Cats (Body Surface Area Formula)\tDeoxycorticosterone 21 acetate (Organic Chemical)\tsmall cell carcinoma of larynx (Neoplastic Process)\tregulation of amine transport (Molecular Function)", + "output": "BSA Formula for Cats (Body Surface Area Formula)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder of sexual development in persons with 46XY karyotype, characterized by an abnormality of the genes encoding androgen receptors. It results in a female sex appearance or the development of both male and female characteristics.\nConcepts: ANDROGEN RECEPTOR DEFICIENCY (Disorder of steroid metabolism)\tFHRV - Fetal heart rate variability (Antepartum fetal status)\tBlasts/Total Cells (Laboratory Procedure)\tHow Much Bothered or Troubled by Not Being Able to Sleep (Intellectual Product)\tInsulin C-peptide measurement (Chemical procedure)", + "output": "ANDROGEN RECEPTOR DEFICIENCY (Disorder of steroid metabolism)" + }, + { + "input": "Definition: Infections and Infestations, CTCAE described as a disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).\nConcepts: Absent photopic (cone) responses on ERG (Abnormal light-adapted electroretinogram)\tALX4 wt Allele (Gene or Genome)\tRecurrent Testicular Lymphoma (Recurrent Primary Malignant Neoplasm)\tStoma Site Infection (Finding)\tCavernous lymphangioma (Congenital lymphatic malformation)", + "output": "Stoma Site Infection (Finding)" + }, + { + "input": "Definition: Biological Clearance Rate described as the total body clearance for intravascular administration, calculated using the predicted value of the last non-zero concentration.\nConcepts: PUL01C (PUL 1.2 Functional Test Question)\tATPase-coupled cGMP transmembrane transporter activity (Molecular Function)\tbreast disease paget's (Primary malignant neoplasm)\tTotal CL Pred (Biological Clearance Rate)\taggressive adult non-Hodgkin's lymphoma stage III (Aggressive Adult Non-Hodgkin Lymphoma)", + "output": "Total CL Pred (Biological Clearance Rate)" + }, + { + "input": "Definition: Porphyrin measurement described as the determination of the amount of protoporphyrin present in a sample.\nConcepts: ErbA-Related Protein-3 (Biologically Active Substance)\tRBC protoporphyrin measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tFatty Acid 18:1 (Fatty Acids, Monounsaturated)\tNeural Grooves (Other Embryologic Structure)\tADL01-Pastime: Other (ADCS-ADL Questionnaire Question)", + "output": "RBC protoporphyrin measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine antisulfated 3-glucuronyl paragloboside antibodies (anti-SGPG antibodies) in which activity is directed against peripheral nerve antigens. These antibodies are mostly found in demyelinating neuropathies.\nConcepts: spectrosome organization (Cell Function)\tVz Pred by F Norm by WT (Predicted Volume of Distribution of Absorbed Fraction)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antimyelin Antibody, SGPG (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antimyelin Antibody)\tsuppression of telomeric recombination at telomere (regulation of DNA recombination at telomere)\tLugano Classification Stage IIE Adult Hodgkin Lymphoma AJCC v8 (Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8)", + "output": "IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antimyelin Antibody, SGPG (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antimyelin Antibody)" + }, + { + "input": "Definition: organic cyclic compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of a purine-containing compound, i.e. any compound that contains purine or a formal derivative thereof.\nConcepts: decaprenyldihydroxybenzoate methyltransferase activity (3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity)\tVestibulocochlear Nerve (craniospinal nerves)\tphospholipase C-activating rhodopsin mediated signaling pathway (phospholipase C-activating G protein-coupled receptor signaling pathway)\tADCRGW19 (ADAS-Cog CDISC Version Questionnaire Question)\tpurine-containing compound catabolism (organonitrogen compound catabolic process)", + "output": "purine-containing compound catabolism (organonitrogen compound catabolic process)" + }, + { + "input": "Definition: something described as any elsewhere undefined homeopathic remedy letter D, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: undef.homeo rmds ltr D narr (Pharmacologic Substance)\tClinical Stage I Cutaneous Melanoma AJCC v8 (Neoplastic Process)\tAmnioscope, device (SCOPES AND CAMERAS)\tSideroblastic anemia (ANEMIAS DUE TO UNKNOWN OR MULTIPLE MECHANISMS)\tFAC100-Sev: Carrying 5-10 Lbs Why Not (Intellectual Product)", + "output": "undef.homeo rmds ltr D narr (Pharmacologic Substance)" + }, + { + "input": "Definition: Idea or Concept described as having the same intensity as another object. Used to describe the results of imaging tests, such as x-rays, MRIs, or CT scans.\nConcepts: Grade 2 Hypoalbuminemia (Hypoalbuminemia, CTCAE 5)\tPODCI1-Put on His/Her Coat (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tOrchitides (Abnormal testis morphology)\tIsointense (Idea or Concept)\tCervical Carcinosarcoma (Malignant Cervical Mixed Epithelial and Mesenchymal Neoplasm)", + "output": "Isointense (Idea or Concept)" + }, + { + "input": "Definition: Regimen Used to Treat Non-Small Cell Lung Carcinoma described as a regimen consisting of cisplatin and docetaxel that can be used in the treatment of non-small cell lung cancer (NSCLC) and squamous cell cancer of the head and neck.\nConcepts: Retinal Cone-Rod Dystrophy (Eye)\tMelanoma of the Conjunctiva cT1a TNM Finding v7 (Finding)\t2',3'-CN Phosphodiesterase (Amino Acid, Peptide, or Protein)\tDocetaxel-Cisplatin (Regimen Used to Treat Malignant Head and Neck Neoplasm)\tFistula, Arterio-Arterial (Vascular anomaly)", + "output": "Docetaxel-Cisplatin (Regimen Used to Treat Malignant Head and Neck Neoplasm)" + }, + { + "input": "Definition: Cell Component described as the giant, cup-shaped axon terminal of a vestibular afferent neuron, serving as a post-synaptic contact to a type I hair cell.\nConcepts: anthropometry (Research Activity)\tArsenic 5+ (Element, Ion, or Isotope)\tReduced muscle fiber beta sarcoglycan (Finding)\tvestibular calyx terminal (Nerve Endings)\tphosphatidyl-inositol-bisphosphate phosphatase activity (Molecular Function)", + "output": "vestibular calyx terminal (Nerve Endings)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in protein sumoylation.\nConcepts: Depression, Postnatal (Major Depressive Disorder)\tDrepanocytes (Red Blood Cell Count measurement)\tZNF451 (Gene or Genome)\tIF-3, Initiation Factor (Prokaryotic Initiation Factors)\tMyosclerosis (Disease or Syndrome)", + "output": "ZNF451 (Gene or Genome)" + }, + { + "input": "Definition: Disorder of soft tissue of trunk described as inflammation of the peritoneum (tissue that lines the abdominal wall and covers most of the organs in the abdomen). Peritonitis can result from infection, injury, or certain diseases. Symptoms may include swelling of the abdomen, severe pain, and weight loss.\nConcepts: FF-10101-01 (Pharmacologic Substance)\tEpidemiology, Pharmaceutical (Pharmacology)\tPeritonitis, NOS (Peritonitis and retroperitoneal infections)\tVascular Medias (General anatomical term)\tALOE VERA TOP GEL (Topical Preparation)", + "output": "Peritonitis, NOS (Peritonitis and retroperitoneal infections)" + }, + { + "input": "Definition: Intellectual Product described as one of a series of documents that are published periodically.\nConcepts: CDISC Questionnaire VFQ25-Self Administered Format Test Name Terminology (CDISC Questionnaire Terminology)\tHYPERICUM OIL (Organic Chemical)\tPODCI1-Pain/Comfort Scale (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tN,N-dibenzyldaunorubicin (Anthracycline Antibiotics)\tIssue (Document type)", + "output": "Issue (Document type)" + }, + { + "input": "Definition: something described as weakness of the peroneal muscles.\nConcepts: ASSAY, PROLIFERATION, IN VITRO, T LYMPHOCYTE (Medical Device)\tferric iron import across cell outer membrane (Cell Function)\tPERONEAL MUSCLE WEAKNESS (MUSCLE SOFT, TISSUE)\tEGFR Gly719Val (EGFR NP 005219.2:p.G719X)\tmacrophage migration inhibitory factor signaling pathway (Cell Function)", + "output": "PERONEAL MUSCLE WEAKNESS (MUSCLE SOFT, TISSUE)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's distress related to their physical problems with pain.\nConcepts: Immediate Release (Biomedical or Dental Material)\tHyperparathyroidism, NOS (Disease or Syndrome)\tMedical History Start Date (Start Date)\theme o catabolic process (Molecular Function)\tDistress over Physical Problem with Pain (Intellectual Product)", + "output": "Distress over Physical Problem with Pain (Intellectual Product)" + }, + { + "input": "Definition: something described as lower intake of boron compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)\nConcepts: piscicida, Pfiesteria (Pfiesteria)\tVentricular Tachycardia, Sustained (Heart)\tPOMC Deficiency (Melanocortin Pathway Defect)\tInadequate boron intake (Finding)\tEarly Diagnosis (Diagnosis)", + "output": "Inadequate boron intake (Finding)" + }, + { + "input": "Definition: Therapeutic Device described as instruments designed for the accurate measurement of the diameter or thickness of an object or, less frequently, the distance between two points on a plane. These instruments are typically metallic, compasslike, handheld instruments with two adjustable, frequently curved, hinged legs or jaws; some instruments display the results of measurements on analog (e.g., mechanical scales) or digital (electronic) displays. Metallic and/or rigid plastic calipers are available with an L-shaped frame with a linear scale along its longer arm and a second L-shaped sliding arm with an auxiliary graduated scale to facilitate fine adjustment and to increase the accuracy of measurement (i.e., vernier calipers). Dedicated clinical calipers are intended mainly to measure organ and/or tissue (e.g., bones, eyes, skin) diameters and/or thicknesses and, less frequently, to determine length and distances on graphic recordings (e.g., electrocardiograms).\nConcepts: Familial Pancreatitis (Pancreatic disorders congenital)\tGrade 3 Hematuria (Hematuria, CTCAE)\tCALIPER (ORTHOPEDIC DEVICES AND HARDWARE)\tHAIRY/ENHANCER OF SPLIT, DROSOPHILA, HOMOLOG OF, 6 (Transcription Coregulator Gene)\tNeoplasm of the Follicular Infundibulum (Neoplastic Process)", + "output": "CALIPER (ORTHOPEDIC DEVICES AND HARDWARE)" + }, + { + "input": "Definition: N-acyltransferase activity described as catalysis of the reaction: crotonyl-CoA + lysine in peptide = CoA + N-crotonyl-lysine-peptide.\nConcepts: AMSLER GRID (Procedure categorized by device involved)\tCSS0906A (Intellectual Product)\tExpectorant (Organic Chemical)\tLCT (Consolidation Therapy)\tpeptide crotonyltransferase activity (Molecular Function)", + "output": "peptide crotonyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as dedifferentiated liposarcoma that is amenable to surgical resection.\nConcepts: Bacteroides melaninogenicus subsp. intermedius Holdeman and Moore 1970 (Bacteroides)\tSubject Age (Age)\theterodyning (Natural Phenomenon or Process)\tResectable Dedifferentiated Liposarcoma (Resectable Liposarcoma)\tAnisospondyly (Finding)", + "output": "Resectable Dedifferentiated Liposarcoma (Resectable Liposarcoma)" + }, + { + "input": "Definition: Cell Function described as programmed cell death that occurs in the developing retina.\nConcepts: retinal programmed cell death (Cell Function)\tNewly Diagnosed (Disease Clinical Qualifier)\tWarming/Cooling Units, Patient, Heart-Lung Bypass (Medical Device)\tHelcococcus kunzii Collins et al. 1993 (Helcococcus)\tTreatment Emergent Flag (Flag)", + "output": "retinal programmed cell death (Cell Function)" + }, + { + "input": "Definition: positive regulation of transcription by RNA polymerase II described as any process that regulates the internal concentration of potassium ions at the level of a cell by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter.\nConcepts: Goiters, Substernal (Thyroid Diseases)\tURL Related to Study Description (Description)\tanti-Mullerian hormone signaling pathway (cell surface receptor signaling pathway)\tChalkley Score (Other Finding)\tregulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter (positive regulation of transcription by RNA polymerase II)", + "output": "regulation of potassium ion concentration by positive regulation of transcription from RNA polymerase II promoter (positive regulation of transcription by RNA polymerase II)" + }, + { + "input": "Definition: Physical therapy described as any treatment designed to lessen the effects of dysphagia. Treatment may include restoration of normal swallow function (rehabilitative), modifications to diet consistency and patient behavior (compensatory), or a combination of these approaches.\nConcepts: beta-1,6-glucosidase activity (Molecular Function)\tmicrotubule plus-end (Microtubules)\tSwallowing promotion therapy (Therapeutic or Preventive Procedure)\tHuman T Cell Leukemia Lymphoma (Virus-Related Lymphoma)\tregulation of postsynaptic dense core vesicle exocytosis (regulation of cellular localization)", + "output": "Swallowing promotion therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: regulation of histone acetylation described as any process that modulates the frequency, rate or extent of histone H3-K27 acetylation.\nConcepts: regulation of histone H3K27 acetylation (regulation of histone acetylation)\tMarital Status Date Range (Temporal Concept)\tIVD Test Reagent/Kits, Serology, Virus, Hepatitis B, X Protein (Medical Device)\tneuregulin binding (Molecular Function)\tPartial hysterectomy (procedure) [Ambiguous] (Hysterectomy)", + "output": "regulation of histone H3K27 acetylation (regulation of histone acetylation)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio) of the Hepatitis C virus antibody signal in a biological specimen to Hepatitis C virus positive internal control.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Phenytoin (Medical Device)\tNERVOUS SYSTEM AZOREAN DIS (Ataxia, Spinocerebellar)\tHCVSHCVC (Immunologic Tests)\tBinet Stage A (Intellectual Product)\tcarbon-oxygen lyase activity, acting on polysaccharides (Molecular Function)", + "output": "HCVSHCVC (Immunologic Tests)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as commissural leaflet of mitral valve which is attached to the posteromedial head of the posterior papillary muscle of left ventricle.\nConcepts: Posterior commissural leaflet of mitral valve (Set of commissural cusps of mitral valve)\tExploratory Behaviors (Individual Behavior)\tLower Case Letter (Qualitative Concept)\tFamily coping impairment (Nursing Assessment Entity)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Anti-Hu Antibody (Medical Device)", + "output": "Posterior commissural leaflet of mitral valve (Set of commissural cusps of mitral valve)" + }, + { + "input": "Definition: Organic Chemical described as the most potent form of the naturally occurring steroid sex hormone in humans, produced by ovary, placenta, testis, and in small amount by adrenal cortex. Estradiol binds to a specific intracellular estrogen receptor located in female organs, breasts, hypothalamus and pituitary. The receptor-ligand complex promotes gene expression necessary for the maintenance of fertility and secondary sexual characteristics in females. In addition, estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability. Estradiol, the principal intracellular human estrogen, is substantially more active at the cellular level than its metabolites, estrone and estriol.\nConcepts: SACT (Intellectual Product)\tFAC10035 (Intellectual Product)\tGenotype-Phenotype Correlation (Finding)\tEstradiol-17 beta (Hormone)\tFHL2 wt Allele (Gene or Genome)", + "output": "Estradiol-17 beta (Hormone)" + }, + { + "input": "Definition: something described as this gene is involved in neuroblast migration and axon guidance.\nConcepts: TYMPANIC MEMBRANE REPAIR (Therapeutic or Preventive Procedure)\tPerformedLesionDescription.lesionNumber (Intellectual Product)\tDAD0142 (DAD Questionnaire Question)\tSDS01-Days Unproductive (Intellectual Product)\tROBO1 gene (Gene or Genome)", + "output": "ROBO1 gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a cholesterol carbonate derivative of 4-demethylpenclomedine (DM-PEN) with potential antineoplastic alkylating activity. Upon intravenous administration of 4-demethylcholesteryloxycarbonylpenclomedine, the carbonium moiety binds to and alkylates DNA at the N7 guanine position, thereby causing DNA crosslinks. This prevents DNA replication, inhibits cellular proliferation and triggers apoptosis. In addition, due to its lipophilic cholesteryl moiety this agent is able to cross the blood brain barrier (BBB) and therefore can be given intravenously compared to other alkylating agents that need to be given intra-cranially. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90539\" active clinical trials using this agent.\nConcepts: North American Indian language (World languages)\t4-DEMETHYLCHOLESTERYLOXYCARBONYLPENCLOMEDINE (Pharmacologic Substance)\tPalpable Masses Location (Spatial Concept)\t4-isopropylaniline dehydrogenase activity (Molecular Function)\tMonitoring Systems, Physiologic, Hemodynamic, Non/Minimally Invasive (Monitoring Systems, Physiologic, Hemodynamic)", + "output": "4-DEMETHYLCHOLESTERYLOXYCARBONYLPENCLOMEDINE (Pharmacologic Substance)" + }, + { + "input": "Definition: Enzyme described as a carboxylating enzyme that catalyzes the conversion of ATP, acetyl-CoA, and HCO3- to ADP, orthophosphate, and malonyl-CoA. It is a biotinyl-protein that also catalyzes transcarboxylation. The plant enzyme also carboxylates propanoyl-CoA and butanoyl-CoA (From Enzyme Nomenclature, 1992) EC 6.4.1.2.\nConcepts: Physical Illness (Physical & Psychosomatic Disorders)\ttrivalent inorganic cation homeostasis (Physiologic Function)\tSouffle, uterine (Clinical sign related to pregnancy)\tUsed Quit Cigarette Smoking Books and/or Pamphlets (Finding)\tCarboxylase, Acetyl-CoA (Multifunctional Enzymes)", + "output": "Carboxylase, Acetyl-CoA (Multifunctional Enzymes)" + }, + { + "input": "Definition: Angioedema described as usually transient vascular reaction involving the upper dermis, representing local edema caused by dilation and increased permeability of the capilliaries and the development of wheals.\nConcepts: Urtication (Dermatoses, General and NEC)\tStage I Lip and Oral Cavity Cancer AJCC v6 and v7 (Lip and Oral Cavity Cancer by AJCC v6 and v7 Stage)\tHypericum Volatile Oil (Plant Oils)\tHealth Personnel, Allied (Professional or Occupational Group)\ttimed up and go (TUG) mobility test (Functional assessment)", + "output": "Urtication (Dermatoses, General and NEC)" + }, + { + "input": "Definition: Toxicology described as the branch of toxicology focusing on the effects of poisons on the immune system.\nConcepts: NELFINAVIR (Chemical categorised functionally)\tImmunotoxicology (Biomedical Occupation or Discipline)\tDoctor and I Shared Responsibility for Deciding Which Treatment is Best for Me (Intellectual Product)\tcardiomyocyte differentiation (cardiocyte differentiation)\tMolindone-containing product (Indoles)", + "output": "Immunotoxicology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare form of juvenile dermatomyositis that manifests with characteristic cutaneous findings for at least six months in the absence of any detectable muscle involvement.\nConcepts: UPDRS - Activities of Daily Living: Walking (Intellectual Product)\tCeramidases (Lysosomal storage disease marker)\tCardiovascular pharmacology (Biomedical Occupation or Discipline)\tvitamine E PEG-1000-succinate (Vitamin)\tJuvenile Dermatomyositis sine Myositis (Dermatomyositis, Childhood Type)", + "output": "Juvenile Dermatomyositis sine Myositis (Dermatomyositis, Childhood Type)" + }, + { + "input": "Definition: something described as older adults or aged individuals who are lacking in general strength and are unusually susceptible to disease or to other infirmity.\nConcepts: Stage II Ovarian Polyembryoma (polyembryoma of ovary)\tElders, Frail (human old age)\tmL/(ug/m2) (Unit of Dose Calculation)\tpaper chromatography (Liquid Chromatography)\t19: 56026591-56020357 (Chromosome 19 Physical Location)", + "output": "Elders, Frail (human old age)" + }, + { + "input": "Definition: Alkylphosphocholine Compound described as a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called alkylphospholipids.\nConcepts: HEMOGLOBIN C (Medical Device)\tPERIFOSINE (Pharmacologic Substance)\tsignaling lymphocytic activation molecule, human (Biologically Active Substance)\tleft-right determination factor 1 protein, human (Transforming Growth Factor beta)\tHeide syndrome (Disease or Syndrome)", + "output": "PERIFOSINE (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the urinary system findings domain.\nConcepts: Mammographic Digital Radiography Workstation Management Software (Intellectual Product)\tUrinary System Findings Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)\tLead Site aVF-Ventral (Electrocardiograph Lead Placement Location)\tColon Adenoma with Severe Dysplasia (Neoplastic Process)\tSphenoid Sinus Schneiderian Papilloma (Benign neoplasm of sphenoidal sinus)", + "output": "Urinary System Findings Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: something described as an assessment of the size difference in comparison to a baseline or previous value.\nConcepts: osteosarcoma, telangiectatic (OSSEOUS AND CHONDROMATOUS NEOPLASMS)\tUDP-N-acetylglucosamine transmembrane transport (pyrimidine nucleotide-sugar transmembrane transport)\tResidual cancer burden index (Research or Clinical Assessment Tool)\tRelative Size Change (Quantitative Concept)\tHEADACHE HISTAMINE (Cluster Headache)", + "output": "Relative Size Change (Quantitative Concept)" + }, + { + "input": "Definition: Myotonus described as an inherited progressive disorder affecting the muscles. It is characterized by muscle wasting and hypotonia, cataracts, heart conduction defects and endocrinopathies.\nConcepts: Abnormal urine phosphate concentration (Abnormal urinary electrolyte concentration)\tsteinert's disease (congenital neuromuscular disorder)\tSOLAMEN syndrome (Lipomatosis)\tSIQ0132 (SIQ Questionnaire Question)\tNCNU (Nitrosourea Compounds)", + "output": "steinert's disease (congenital neuromuscular disorder)" + }, + { + "input": "Definition: Abnormal 3rd finger phalanx morphology described as a third finger with short and wide phalanx that tapers distally. Bullet-shaped phalanges lack the normal diaphyseal constriction.\nConcepts: methylgalactoside transmembrane transporter activity (carbohydrate derivative transmembrane transporter activity)\tHalf-sibling (Natural sibling)\tComplications, Postoperative (Pathologic Processes)\tNitro-compound Carcinogen (Classification)\tBullet-shaped phalanges of the 3rd finger (Anatomical Abnormality)", + "output": "Bullet-shaped phalanges of the 3rd finger (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as warming units designed for temporary food storage at temperatures below the water boiling point (typical temperatures are 80 to 85 degrees Celsius/176 to 185 degrees Farenheit). These units usually consist of cabinet-like structures; the units are usually available in stand-alone or under counter configurations. They may include forced-air circulation systems, humidity and temperature controls, and alarms in addition to the heaters. Food warming units are used to keep prepared food warm for a short time before its distribution; units including racks that can accommodate roll-in baking pans to activate yeast in food containing flour mixtures (i.e., proofing units) are also available.\nConcepts: Nitrobenzylmercaptopurine Riboside (NBMPR)-Insensitive, Equilibrative Nucleoside Transporter (Amino Acid, Peptide, or Protein)\tB cell receptor transport within lipid bilayer (protein transport within lipid bilayer)\tWarming Units, Food (Medical Device)\tFLUORESCENCE, VISUAL OBSERVATION (QUAL., U.V.), GLUTATHIONE REDUCTASE (Indicator, Reagent, or Diagnostic Aid)\tDentifrices (Device associated with dental materials)", + "output": "Warming Units, Food (Medical Device)" + }, + { + "input": "Definition: Mass of abdominal cavity structure described as an abnormal growth in the adrenal gland.\nConcepts: Apex cardiograph (Device associated with transducers)\tHeme Regulated eIF 2alpha Kinase (Enzyme)\tMass of adrenal gland (Disease or Syndrome)\tGorilla (Mammal)\tU2 snRNA 3' end processing (snRNA 3'-end processing)", + "output": "Mass of adrenal gland (Disease or Syndrome)" + }, + { + "input": "Definition: Blepharal carcinoma described as a term that refers to the staging of eyelid carcinoma according to the American Joint Committee on Cancer, 8th edition. This staging system applies to all primary carcinomas of the eyelid, including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), sebaceous carcinoma, and other rare carcinomas, such as all varieties of sweat gland carcinoma (e.g., eccrine carcinoma). It does not apply to carcinomas of the head and neck with direct extension to eyelid (are staged according to the cutaneous squamous cell carcinomas of the head and neck), Merkel cell carcinomas of the eyelid (are staged according to the classification for Merkel cell carcinomas), and melanomas of the eyelid (are staged according to the classification for melanomas of the skin).\nConcepts: Eyelid Carcinoma by AJCC v8 Stage (Blepharal carcinoma)\tPETEST (Intellectual Product)\tSPECIES (Intellectual Product)\tDystopic os odontoideum (Finding)\tfluids pleural (Body part)", + "output": "Eyelid Carcinoma by AJCC v8 Stage (Blepharal carcinoma)" + }, + { + "input": "Definition: Medical Device described as plain (nonimpregnated) dressings made of synthetic (e.g., polymers) or semisynthetic materials. These dressings may be adhesive or nonadhesive, and made of one or more synthetic polymers, including polyethylene and polyurethane. Synthetic dressings are intended to maintain a moist environment, absorb wound exudates and/or prevent the dressings from contact with bacteria; they are used in the management of dry or exudative wounds.\nConcepts: Deep external pudendal vein (Body Part, Organ, or Organ Component)\tHIV gag Gene Product p24 (Amino Acid, Peptide, or Protein)\tLipodystrophy, Reverse Partial (Hereditary Connective Tissue Disorder)\tNEU Overexpression (Finding)\tSynthetic Dressings, Non-Impregnated (Medical Device)", + "output": "Synthetic Dressings, Non-Impregnated (Medical Device)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of iridophore differentiation.\nConcepts: Streptococcus faecalis ATCC 9790 (Bacterium)\tphase contrast microscopy (Light Microscopy)\tLimitations in Use of Hands or Fingers; Requires Help for All Tasks (Finding)\tregulation of iridophore differentiation (regulation of pigment cell differentiation)\tPatella (Eukaryote)", + "output": "regulation of iridophore differentiation (regulation of pigment cell differentiation)" + }, + { + "input": "Definition: Terminology Subset described as terminology used in support of the American College of Cardiology (ACC)/American Heart Association's (AHA) efforts to collect key elements pertaining to clinical data obtained from electronic health records.\nConcepts: American College of Cardiology/American Heart Association Electronic Health Records Terminology (Intellectual Product)\tPSTIMLSP (Quantitative Concept)\tplatelet-derived growth factor receptor-like gene product, human (Candidate Tumor Suppressor Protein)\tROS1 Rearrangement (Cell or Molecular Dysfunction)\tEyelid Carcinoma pT3c TNM Finding v8 (Finding)", + "output": "American College of Cardiology/American Heart Association Electronic Health Records Terminology (Intellectual Product)" + }, + { + "input": "Definition: COMPLEX MIXED AND STROMAL NEOPLASMS described as malignant kidney tumor made up of three cell types: blastemal, stromal, and epithelial, but not all present in every case.\nConcepts: weanling animal (Animal)\tSocietal attitudes (Social Behavior)\tt(12;22)(q13;q12) (Chromosomal translocation)\twilm's tumor (Embryonal Neoplasm)\tcellular response to tropane (cellular response to alkaloid)", + "output": "wilm's tumor (Embryonal Neoplasm)" + }, + { + "input": "Definition: negative regulation of cardiac chamber morphogenesis described as any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis.\nConcepts: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis (Cell Function)\tregulation of Golgi calcium ion concentration (cellular calcium ion homeostasis)\teye photoreceptor cell fate commitment (Cell Function)\tInactivating CDKN2B Mutation (Cell or Molecular Dysfunction)\tDrug Shortage (Qualitative Concept)", + "output": "negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis (Cell Function)" + }, + { + "input": "Definition: something described as serous cystadenoma of childhood is a benign epithelial ovarian neoplasm with characteristics of a usually unilateral, cystic, unilocular or multilocular lesion with a thin wall or septa and no intracystic solid portion on imaging. It often presents with abdominal pain or an asymptomatic abdominal mass and can be associated with ovarian torsion or malignant transformation.\nConcepts: Farnesyl Transferase Inhibitor (Pharmacologic Substance)\tSDTM-RSKASMT (CDISC SDTM Terminology)\tMajor Salivary Gland Carcinoma pT4b TNM Finding v8 (Major Salivary Gland Cancer pT4 TNM Finding v8)\tSerous cystadenoma of ovary in childhood (Serous cystadenoma of ovary)\tregulation of oligodendrocyte apoptosis (regulation of glial cell apoptotic process)", + "output": "Serous cystadenoma of ovary in childhood (Serous cystadenoma of ovary)" + }, + { + "input": "Definition: something described as UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.\nConcepts: VORTICELLA (Vorticellidae)\tLymphofolliculosis, Eosinophilic (Salivary Gland Diseases)\tLow serum potassium level (Potassium imbalance)\tthreatened; abortion (Pathologic Function)\tSKIP1 protein, human (Signaling Protein)", + "output": "threatened; abortion (Pathologic Function)" + }, + { + "input": "Definition: CONGENITAL ANOMALIES OF THE GENITAL SYSTEMS: GENERAL CONDITIONS described as gonads of one sex are present, while the external genital organs resemble in whole or in part those of the opposite sex. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)\nConcepts: carcinine import across plasma membrane (Import into cell)\tDysgenetic pseudohermaphroditism syndrome (Congenital Abnormality)\tcarnitine transmembrane transporter activity (quaternary ammonium group transmembrane transporter activity)\tPALB2-Mutated Breast Carcinoma (Breast Cancer, Familial)\tCefetecol (Cephalosporins)", + "output": "Dysgenetic pseudohermaphroditism syndrome (Congenital Abnormality)" + }, + { + "input": "Definition: Idea or Concept described as partiality, favor, priority or advantage granted to one over another; a liking for a person, place, thing, behavior, action, etc.; closely related to CHOICE and BIAS.\nConcepts: IB Receipt Confirmation (Document type)\tPreferred (Attitude)\tPerformed Product Investigation Result Defect Type Code (Defect Type Code)\tdown-regulation of dendrite morphogenesis (regulation of dendrite morphogenesis)\tMeat-Packing Industries (Organization)", + "output": "Preferred (Attitude)" + }, + { + "input": "Definition: Effervescent tablet described as solid preparation consisting of a tablet usually containing acid substances and carbonates or hydrogen carbonates that react rapidly in the presence of aqueous liquid to release carbon dioxide, intended for generation of vapour to be inhaled to obtain a local effect. The vapour may be generated by adding the tablet to hot water.\nConcepts: Pancreatic divisum (Congenital Abnormality)\tPhosphoramides (Phosphates)\tATF1 (Amino Acid, Peptide, or Protein)\tEffervescent Tablet Inhalation Vapor (Biomedical or Dental Material)\tCELL DYSPLASIA KIDNEY (Renal disorders NEC)", + "output": "Effervescent Tablet Inhalation Vapor (Biomedical or Dental Material)" + }, + { + "input": "Definition: Heart valve disease described as dysfunction of one of the cardiac valves characterized by incomplete valve closure.\nConcepts: Intrauterine (Dose form intended site)\tInsufficiency, Valvular (Cardiac flow)\tCapgras Syndrome (Miscellaneous Mental Disorders, Syndromes and Conditions)\tpolyphenic determination (Phenomenon or Process)\tTFIIH Core Subunit Gene (Gene or Genome)", + "output": "Insufficiency, Valvular (Cardiac flow)" + }, + { + "input": "Definition: something described as minutes times micromoles per liter, divided by meters squared.\nConcepts: Carbohydrate deficient glycoprotein syndrome (Syndrome)\tPast 30 Days Smoked Any Cigarettes (Intellectual Product)\tmin.umol/l/m2 (Measurement Unit Description)\tUnable to walk alone, even with walking equipment. Able to walk short distances with the help of another person, and required a wheelchair to get around the neighborhood (Finding)\tDense calvaria (Skull)", + "output": "min.umol/l/m2 (Measurement Unit Description)" + }, + { + "input": "Definition: Genetic Function described as interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II.\nConcepts: Triangular shaped distal phalanx of the thumb (Triangular shaped distal phalanges of the hand)\txstng hm visit 60min (Existing client home-visit with ICD diagnosis)\tpyridoxine deficiency (Deficiency of other B group vitamins)\tRNA polymerase II transcription factor binding (transcription factor binding)\tAplasia cutis congenita, naevus sebaceous syndrome (Congenital anomaly of visual system)", + "output": "RNA polymerase II transcription factor binding (transcription factor binding)" + }, + { + "input": "Definition: something described as a species of obligately anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Bacteroidetes. This species is nonmotile, non-spore forming, pigmented, sucrose and indole positive, but xylose, arabinose, cellobiose, rhamnose, salicin, lactose, esculin hydrolysis, beta-N-acetyl-glucosaminidase, beta-glucosidase and glycine aminopeptidase negative. P. intermedia is found in gingival crevices where it can cause gingivitis, chronic periodontitis, and other infections of the oral cavity, but is also associated with abscesses and a variety of systemic infections.\nConcepts: [2aR-[2a alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester (Plant Extracts)\tBacteroides intermedia (Bacterium)\tvelocardiofacial syndrome (Transcription factor genes)\tEritrea (Country)\ttransferase activity, transferring aldehyde or ketonic groups (Molecular Function)", + "output": "Bacteroides intermedia (Bacterium)" + }, + { + "input": "Definition: Epilepsy described as an autosomal dominant condition caused by mutation(s) in the LGI1 gene, encoding leucine-rich glioma-inactivated protein 1. It is characterized by partial seizures originating in the temporal lobe and often accompanied by auditory sensory manifestations.\nConcepts: downregulation of cell communication by electrical coupling involved in cardiac conduction (regulation of cell communication by electrical coupling involved in cardiac conduction)\tEpilepsy, Familial Temporal Lobe 1 (Disease or Syndrome)\tC147279 (Laboratory Procedure)\tdcr (Operation on lacrimal sac)\tEnlargement;thyroid (Viscus structure finding)", + "output": "Epilepsy, Familial Temporal Lobe 1 (Disease or Syndrome)" + }, + { + "input": "Definition: In Vitro Diagnostics and Laboratory Equipment described as a densitometer is a device used to measure the transmission of light through an indicator in a sample of blood.\nConcepts: EFS (Intellectual Product)\tShortness of Breath Score 1 (Intellectual Product)\tdensitometers (In Vitro Diagnostics and Laboratory Equipment)\tMT3 Receptor, Melatonin (Receptor)\tN-acetylphosphatidylethanolamine-hydrolysing phospholipase activity (phosphoric diester hydrolase activity)", + "output": "densitometers (In Vitro Diagnostics and Laboratory Equipment)" + }, + { + "input": "Definition: something described as upper limb prostheses designed for partial functional (e.g., rotation, flexion) and/or cosmetic replacement of the distal portion of a limb amputated at the shoulder articulation, in which the shoulder blade (i.e., the glenoid cavity) of the articulation is preserved. These prostheses typically consist of external or partially implantable devices with an elbow, a wrist, and a terminal device (e.g., hand, hook) and with a mechanism that provides rotational and flexion movements and locking positions at the distal end. They are usually attached at the proximal end with a thoracic socket (e.g., basket, frame-style) that encloses and rests on the shoulder girdle and thoracic area to optimize stability and provide a sturdy mounting surface for control switches of externally powered prostheses. The prostheses may be mechanically operated (e.g., using cables and springs) or electrically powered (e.g., using external switches, electronic controls, and electrical motors). Shoulder disarticulation prostheses are available in a great variety of configurations and sizes; they are used in patients who suffered amputations due to illness (e.g., diabetes), or traumatic accidents or, less frequently, in patients who have congenital abnormalities.\nConcepts: Papillary adenofibroma (Neoplastic Process)\tBAFME - Benign adult familial myoclonic epilepsy (Autosomal dominant hereditary disorder)\tChildhood Carcinoid Tumor (Neoplastic Process)\tDAD0128 (Intellectual Product)\tProstheses, Upper Limb, Shoulder Disarticulation (Medical Device)", + "output": "Prostheses, Upper Limb, Shoulder Disarticulation (Medical Device)" + }, + { + "input": "Definition: Event Occurrence Indicator described as an indication or description that substance usage is continuing.\nConcepts: CUSHION, EARPHONE (Medical Device)\tTHERMAL IONIZATION MASS SPECTROMETRY (Mass Spectrometry)\tOngoing Substance Use (Event Occurrence Indicator)\tProvenge Regimen (Regimen Used to Treat Prostate Carcinoma)\tagonistic anti-CD134 monoclonal antibody MEDI6469 (Anti-OX40 Monoclonal Antibody)", + "output": "Ongoing Substance Use (Event Occurrence Indicator)" + }, + { + "input": "Definition: something described as catalysis of the reaction: bixin + S-adenosyl-L-methionine <=> bixin dimethyl ester + S-adenosyl-L-homocysteine.\nConcepts: antitumor (Qualitative Concept)\tchemical informatics (Science of Chemistry)\tFerrum pernitricum / iron pernitrate (Inorganic Chemical)\tbixin methyltransferase activity (methyltransferase activity)\tSerous pericardium of superior pulmonary vein (Serous pericardium of pulmonary vein)", + "output": "bixin methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: Peptides described as mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.\nConcepts: stereotactic radiation therapy (Radiosurgery)\tFactor, Platelet-Derived Growth (Intercellular Signaling Peptides and Proteins)\tPerson.name (Name)\tacrodermatitis (Inflammatory dermatosis)\t8: 143542379-143623370 (Chromosome 8 Physical Location)", + "output": "Factor, Platelet-Derived Growth (Intercellular Signaling Peptides and Proteins)" + }, + { + "input": "Definition: Neuroanatomy described as denotes a composite substructure that includes nuclei in the midline of the reticular formation (classical) of the upper cerebrospinal trunk extending from the caudal medulla to the midbrain. It includes the raphe nuclei of the medulla ( nucleus raphe magnus, nucleus raphe obscurus and nucleus raphe pallidus); the nucleus raphe pontis and the inferior central nucleus of the pontine reticular formation and the dorsal raphe nucleus and the median raphe nucleus of the midbrain reticular formation ( Carpenter-1983 ). Recent authors include the caudal linear nucleus of the raphe ( Hornung-2012 ) or both the caudal and the rostral linear nucleus of the raphe ( Paxinos-2012 ).\\r\\nAll of the nuclei except the rostral linear nucleus overlap the serotonergic cell groups ( Hornung-2012 ). They are found in the human ( Paxinos-2012 ), the macaque ( Paxinos-2009a ), the rat ( Paxinos-2009b ) and the mouse ( Franklin-2008 ). See also raphe nuclei (functional).\nConcepts: Branch of dorsalis pedis artery (Structure of dorsum of foot)\tBohr effect (Respiration)\tNucleus raphe (Body Part, Organ, or Organ Component)\tLaparoscopic Radical Prostatectomy with Robotics (Laparoscopic Radical Prostatectomy)\tGlaucarubolone (Pharmacologic Substance)", + "output": "Nucleus raphe (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as serology reagents intended to detect antibodies to Parainfluenza viruses, a group of single-stranded RNA viruses of the family Paramyxoviridae. Parainfluenza viruses affecting humans are classified into the genera Paramyxovirus (including human Parainfluenza virus types 1 and 3) and Rubulavirus (includes human Parainfluenza virus types 2 and 4). These viruses are the etiologic agent of parainfluenza and several upper respiratory tract infections (e.g., bronchitis, pneumonia) of varying severity. Dedicated reagents are available to identify particular types of Parainfluenza viruses.\nConcepts: hyaluronic acid (Laboratory Procedure)\tPQL11-Hard Tell Doctors/Nurses How Feel (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults Questionnaire Question)\tIVD Test Reagent/Kits, Serology, Virus, Parainfluenza, Antibody (Medical Device)\tbutyryl-CoA catabolism (fatty-acyl-CoA catabolic process)\tcomplement component C3a binding (complement binding)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Parainfluenza, Antibody (Medical Device)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Children - Remembering scary things.\nConcepts: TSCC0112 (Intellectual Product)\tAPPROVED DRUG PRODUCT MANUFACTURED EXCLUSIVELY FOR PRIVATE LABEL DISTRIBUTOR (Qualitative Concept)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Eastern Equine Encephalitis, RNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Eastern Equine Encephalitis)\tNebule Dosing Unit (Quantitative Concept)\tFACT-L Version 4 - I am Forced to Spend Time in Bed (Intellectual Product)", + "output": "TSCC0112 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as chronic Respiratory Questionnaire Self-Administered Standardized Format Follow-Up Administration Version Questionnaire (CRQ-SAS Follow-Up Administration Version) In general, how often during the last 2 weeks have you felt restless, tense, or uptight?\nConcepts: CRQ02-Felt Restless, Tense or Uptight (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\tIntermediate frontal area (Body Part, Organ, or Organ Component)\tMycosis Fungoides and Sezary Syndrome NX TNM Finding v8 (Finding)\tVLA-3 complex (integrin complex)\tmV2/Hz (Unit of Electricity and Magnetism)", + "output": "CRQ02-Felt Restless, Tense or Uptight (CRQ-SAS Follow-Up Administration Version Questionnaire Question)" + }, + { + "input": "Definition: Topical anti-infective described as the hemisulfate salt form of proflavine, an acridine-derived fluorescent contrast and disinfectant agent that can potentially be used for cellular imaging and antiseptic purposes. Upon topical application of proflavine hemisulfate, proflavine diffuses into cells and intercalates into DNA, thereby accumulating in and staining the nucleus. During fluorescence imaging, the cell nuclei can be visualized. This allows nuclear morphometry and the identification of cancer cells. In addition, proflavine exerts its antibacterial effect by binding to bacterial DNA, thereby disrupting DNA synthesis and halting bacterial cell growth.\nConcepts: SPR-2 (Transcription factor genes)\tCSS07-Non-Spec Suicid Thought-P6M (Intellectual Product)\tBenign congenital hypotonia (Congenital anomaly of muscle AND/OR tendon)\tProflavine hemisulfate (P [Preparations])\tcarboplatin-etoposide-vincristine regimen (Therapeutic or Preventive Procedure)", + "output": "Proflavine hemisulfate (P [Preparations])" + }, + { + "input": "Definition: something described as cellular accumulation of GM1 gangliosides.\nConcepts: pentamidine isethionate (Antiprotozoal Agents)\tEarly Inflammatory Arthritis (Disease or Syndrome)\tGM1-ganglioside accumulation (Finding)\tSellar Neurilemmoma (Neoplastic Process)\tTracheitis, CTCAE (Infections and Infestations, CTCAE)", + "output": "GM1-ganglioside accumulation (Finding)" + }, + { + "input": "Definition: Adrenal Cortex Hormones described as a drug used to help patients gain weight after injury, chronic infection, or severe illness. It belongs to the family of drugs called anabolic steroids.\nConcepts: IFN-Lambda-4 (Amino Acid, Peptide, or Protein)\tendosomal proteolysis associated with antigen processing and presentation (proteolysis associated with antigen processing and presentation)\tUterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Clinical Distant Metastasis TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Clinical TNM Finding v8)\tToxaemia of pregnancy, NOS (Hypertensive disease)\tOxandrolon (Adrenal Cortex Hormones)", + "output": "Oxandrolon (Adrenal Cortex Hormones)" + }, + { + "input": "Definition: something described as the human MIR125A wild-type allele is located in the vicinity of 19q13.33 and is approximately 85 bases in length. This allele, which encodes MIR125A pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with development of medulloblastoma and breast cancer.\nConcepts: hsa-mir-125a (MIR125A gene)\tScleranthus, Bach flower essence (Pharmacologic Substance)\tRenin Activity Measurement (Protein or Enzyme Type Measurement)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Neisseria gonorrhoeae, rRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Neisseria gonorrhoeae)\tE.F.G complex (Cell Component)", + "output": "hsa-mir-125a (MIR125A gene)" + }, + { + "input": "Definition: Functions and Abnormal Functions of the Esophagus described as the act of taking solids and liquids into the GASTROINTESTINAL TRACT through the mouth and throat.\nConcepts: Colon diverticulitis (Colonic lesion)\tMonosomy 10p11.21p12.31 (Multiple malformation syndrome with facial defects as major feature)\tswallowing (Physiological action)\tCare Facility, Extended (Nursing Homes)\tSST receptor activity (Molecular Function)", + "output": "swallowing (Physiological action)" + }, + { + "input": "Definition: Communication impairment described as using speech and language rehabilitation therapy, including brain activation exercises, with a patient to improve his or her ability to name objects and/or to recognize the written and/or spoken names of objects.\nConcepts: Genus Aquifex (Aquificaceae)\tregulation by symbiont of host excretion (regulation of excretion)\tPancreatic Neuroendocrine Microadenoma (Non functioning pancreatic endocrine tumor)\tEthmoidal Artery (Branch of ophthalmic artery)\tAnomia speech and language rehabilitation (Communication impairment)", + "output": "Anomia speech and language rehabilitation (Communication impairment)" + }, + { + "input": "Definition: Supplemental Qualifiers Tabulation Dataset described as a dataset used to represent non-standard variables and their association to parent records in the Biospecimen Events domain.\nConcepts: Gastric Carcinoma pTis TNM Finding v8 (Finding)\tdislocations wrist (Abnormality of the wrist)\tmandibular condyle (Temporomandibular Joint)\tSupplemental Qualifiers for Biospecimen Events (Intellectual Product)\tLipoxygenases (Nonheme Iron Proteins)", + "output": "Supplemental Qualifiers for Biospecimen Events (Intellectual Product)" + }, + { + "input": "Definition: Electromechanical Devices described as instruments designed to measure the functional length andor to dilate and measure the lumen of the urethra. These devices are typically manual, handheld instruments consisting of a set of cylindrical (e.g., metallic, plastic) urethral dilators of several sizes and a mechanism that displays the diameter and/or degree of dilation (i.e., expansion) of the urethral conduit on a dial. Instruments intended to measure the functional length of the urethra (urethral profile) are also available. Urethrometers are intended to measure the urethra during procedures such as urethral stricture dilation and urethral abnormality studies.\nConcepts: 21p (Arm of chromosome)\tLate Endosomal/Lysosomal Adaptor and MAPK and MTOR Activator 5 (Amino Acid, Peptide, or Protein)\tUrethrometers (Electromechanical Devices)\tCutaneous (Spatial Concept)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MAPT (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Urethrometers (Electromechanical Devices)" + }, + { + "input": "Definition: something described as the conditions contributing to the treatment related mortality.\nConcepts: Epstein-Barr Early Antigen (Immunologic Tests)\tEnterobacter cloacae complex (Bacterium)\tSupplemental Qualifiers for Protocol Deviations (Intellectual Product)\tcytolysis by symbiont of host cells (cytolysis in other organism involved in symbiotic interaction)\tDetails of Treatment Related Mortality (Details)", + "output": "Details of Treatment Related Mortality (Details)" + }, + { + "input": "Definition: Oils, Volatile described as ravensara.\nConcepts: Male genital organs (Urogenital organ)\travensara aromatica (Oils, Volatile)\tElongated superior cerebellar peduncle (Finding)\tATG (Caribbean Islands)\tADCS-ADL Severe Dementia - Description of Usual Performance of Finding Personal Belonging at Home (ADCS-ADL Severe Dementia Questionnaire Question)", + "output": "ravensara aromatica (Oils, Volatile)" + }, + { + "input": "Definition: something described as the myosin part of any complex of actin, myosin, and accessory proteins.\nConcepts: Stomach Aspirator/Irrigators (Medical Device)\tNitri spiritus dulcis / sweet spirits of nitre (Organic Chemical)\tLabel Type Flag (Flag)\tEpidural block (Local anesthetic nerve block around spinal cord meninges)\tactomyosin, myosin complex location part (Cell Component)", + "output": "actomyosin, myosin complex location part (Cell Component)" + }, + { + "input": "Definition: ovulation cycle process described as increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.\nConcepts: Inactivating BAP1 Mutation Positive (Positive Laboratory Test Result)\tmixed tissue and cell culture (Laboratory Procedure)\tStage III Ampulla of Vater Cancer (Neoplastic Process)\tpreantral ovarian follicle growth (ovulation cycle process)\tDeath, Brain (Other conditions of brain)", + "output": "preantral ovarian follicle growth (ovulation cycle process)" + }, + { + "input": "Definition: something described as a standardized 19-item rating scale for symptoms of advanced kidney cancer that is comprised of disease-related, treatment side effects, and general function and well-being subscales. Originally developed by Rao et al. in 2006, it is a modified version of the National Comprehensive Cancer Network (NCCN) 15-item Functional Assessment of Cancer Therapy - Kidney Symptom Index (FKSI-15) that incorporates additional symptoms rated as highest priority by patients and clinicians from the Functional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-Related Symptoms (FKSI-DRS).\nConcepts: Stage IV Renal Cell Carcinoma AJCC v8 (Renal Cell Cancer by AJCC v8 Stage)\tornaline synthase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tOviduct (Animal Structures)\tenterostomal therapist (Biomedical Occupation or Discipline)\tNational Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Kidney Symptom Index-19 Version 2 Questionnaire (Intellectual Product)", + "output": "National Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Kidney Symptom Index-19 Version 2 Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Psychotropic Drugs described as one of several indole alkaloids extracted from Tabernanthe iboga, Baill. It has a complex pharmacological profile, and interacts with multiple systems of neurotransmission. Ibogaine has psychoactive properties and appears to modulate tolerance to opiates.\nConcepts: 12-Methoxyibogamine (methoxyindole)\tmembrane-enclosed organelle (Cell Component)\tportal hypertension (Liver diseases)\tchorionic trophoblast cell development (Cell Function)\tMelanoma of the Conjunctiva pT4 TNM Finding v7 (Melanoma of the Conjunctiva Pathologic Primary Tumor TNM Finding v7)", + "output": "12-Methoxyibogamine (methoxyindole)" + }, + { + "input": "Definition: something described as any process that activates, maintains or increases the frequency, rate or extent of zoospore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Non-tuberculous mycobacteria (Microbiology procedure)\tpositive regulation of zoospore encystment on host (modulation of zoospore encystment on host)\tLung Carcinoma by AJCC v6 Stage (Carcinoma of lung)\tWD5D1 5 (Intellectual Product)\tOrganization Role (Generic Role)", + "output": "positive regulation of zoospore encystment on host (modulation of zoospore encystment on host)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in transcriptional regulation of immune processes.\nConcepts: transforming growth factor, beta 2 (Transforming Growth Factor-Beta Family Gene)\tNeovascularization inhibitors (ophthalmic preparation)\tCentimeter (SI Unit of length)\tCarrot/Jilin Ginseng/Licorice Root/Tangerine Peel/Soy Beverage (Dietary Supplements)\tIREL (Gene or Genome)", + "output": "IREL (Gene or Genome)" + }, + { + "input": "Definition: Leukopoiesis described as the hematopoietic process that refers to the production of granulocytes.\nConcepts: regulation of heart induction by canonical Wnt signaling pathway (Cell Function)\tGranulopoiesis (Leukocyte Differentiation)\tblood cell counts low red (Abnormality of red blood cells)\tOrder (Intellectual Product)\tN-(5-chloropyridin-2-yl)-N'-((1S,2R,4S)-4-(N,N-dimethylcarbamoyl)-2-(5-methyl-4,5,6,7- tetrahydro(1,3)thiazolo(5,4-c)pyridine-2-carboxamido)cyclohexyl)oxamide (Fibrinolytic Agents)", + "output": "Granulopoiesis (Leukocyte Differentiation)" + }, + { + "input": "Definition: Medication Management described as the current medications an individual is taking.\nConcepts: Sinonasal Adenocarcinoma, Intestinal-Type with Colonic Pattern (Sinonasal Adenocarcinoma, Intestinal-Type)\tsalivary gland cell death (programmed cell death involved in cell development)\tCurrent Medication (Medication Management)\tmalignant extra-adrenal paraganglioma (Paraganglioma AND/OR glomus tumor)\tBORTEZOMIB (Antineoplastic Agents)", + "output": "Current Medication (Medication Management)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as trunk of lymphatic tree organ part, each instance of which is either of the two lymphatic trunks (right and left) that drain some pulmonary, bronchopulmonary, tracheobronchial, tracheal, and parasternal lymphatic chains (lymph nodes and lymphatic vessels): that on the right side drains into some right lymphatic duct or subclavian vein, and that on the left into some thoracic duct or some subclavian vein.\nConcepts: Weak Opioids (Finding)\tGrade 2 Tooth infection (Tooth Infection, CTCAE)\tAnti-ICOS Agonist MAb JTX-2011 (Amino Acid, Peptide, or Protein)\tnegative regulation of proteolysis associated with antigen processing and presentation (regulation of proteolysis associated with antigen processing and presentation)\tBronchomediastinal lymph trunk (Structure of lymphatic vessel of mediastinum)", + "output": "Bronchomediastinal lymph trunk (Structure of lymphatic vessel of mediastinum)" + }, + { + "input": "Definition: aminotransferase activity described as catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate.\nConcepts: down-regulation of coagulation (negative regulation of multicellular organismal process)\tCompartment of lumbar vertebral column (Intervertebral compartment)\tGenus Cytomegalovirus (Betaherpesvirinae)\tbrain third ventricle (Body Space or Junction)\tpyridoxamine 5'-phosphate transaminase activity (Molecular Function)", + "output": "pyridoxamine 5'-phosphate transaminase activity (Molecular Function)" + }, + { + "input": "Definition: Genetics, Population described as the regular and simultaneous occurrence of alternative nucleotide sequences at equivalent locations of the genetic material among individuals of a single interbreeding population that are not maintained by recurrent mutation. Polymorphisms may range in size from single nucleotide to large nucleotide sequence variation visible at the chromosomal level.\nConcepts: IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Diabetes Mellitus Type 2, Del/Dup (IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Diabetes Mellitus Type 2)\tMegakaryocyte and Megakaryoblast Morph (Hematologic Tests)\tReply Card (Intellectual Product)\tgene polymorphism (Variation)\tAuditory evoked-potential graphic recorder (Stimulator)", + "output": "gene polymorphism (Variation)" + }, + { + "input": "Definition: Cell Function described as a process that occurs in response to signals generated as a result of G2/M transition DNA damage checkpoint signaling.\nConcepts: CHISEL, OSTEOTOME, SURGICAL (Medical Device)\tG2/M transition DNA damage checkpoint effector process (response to DNA damage checkpoint signaling)\tGemifloxacin mesylate (Pharmacologic Substance)\tSelf-Reported and Medical Record (Self-Report)\tChildhood Spindle Cell Rhabdomyosarcoma (Spindle cell rhabdomyosarcoma)", + "output": "G2/M transition DNA damage checkpoint effector process (response to DNA damage checkpoint signaling)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a course of radiotherapy where minimal imaging support (i.e. X-rays films) is used to determine the positioning of radiotherapy.\nConcepts: 2D Conventional Radiotherapy (Therapeutic or Preventive Procedure)\tacidosis lactic (Metabolic acidosis)\tAggregatibacter Norskov-Lauritsen and Kilian 2006 (Pasteurellaceae)\tUnable to perform breast-feeding (Breast finding)\tTransition zone like (Finding)", + "output": "2D Conventional Radiotherapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as this gene plays a role in RNA splicing.\nConcepts: CSS0618B (C-SSRS Children's Baseline Questionnaire Question)\tUnderdevelopment of zygomatic bone (Anatomical Abnormality)\tDHX16 Gene (Gene or Genome)\tUreteric Anastomotic Leakage (Urinary Tract Anastomotic Leakage)\tVelpatasvir-containing product (ethyl ether)", + "output": "DHX16 Gene (Gene or Genome)" + }, + { + "input": "Definition: appendage morphogenesis described as the process in which the anatomical structures of a fin are generated and organized.\nConcepts: fin morphogenesis (Organism Function)\tTrial Operations Subcategory (Document type)\tST Segment Depression, Aggregate (Quantitative Concept)\tBiocompatibility Problem Identified (Finding)\tSpleen Neoplasm (Disorder of abdomen)", + "output": "fin morphogenesis (Organism Function)" + }, + { + "input": "Definition: Physical shape described as an increase in the number of mitotic figures.\nConcepts: Low-output congestive heart failure (Disease or Syndrome)\tastrocyte chemotaxis (cell chemotaxis)\tAIDS-Related Malignant Tumor of Anus (Malignant neoplasm of anus)\tStage 0is Bladder Cancer (Stage 0 Bladder Carcinoma)\tMITOTIC FIGURES, INCREASED (Physical shape)", + "output": "MITOTIC FIGURES, INCREASED (Physical shape)" + }, + { + "input": "Definition: Disease or Syndrome described as an association of endocrine and neuroectodermal abnormalities consisting of growth hormone deficiency, diabetes mellitus, alopecia, deafness, hypogonadism, anosmia, pili torti, retinitis pigmentosa, and mental retardation.\nConcepts: Nurse simple new home-visit 10 minutes (Health Care Activity)\tresponse to amino acid starvation (Organism Function)\tColorectal Neuroendocrine Tumor by AJCC v8 Stage (Colorectal Neuroendocrine Tumor)\tParenchyma Cell, Palisade (Cell)\tfamilial endocrine-neuroectodermal abnormalities syndrome (Disease or Syndrome)", + "output": "familial endocrine-neuroectodermal abnormalities syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as any process that mediates the transfer of information from one cell to another.\nConcepts: PALSY (Finding)\tintralumenal vesicle formation (endosome organization)\tcell-cell signalling involved in placenta development (Intercellular Communication Process)\tGastric Acid Secretion Inhibition (Gastrointestinal Secretory Inhibition)\tGlycogen storage disease type 0a (Disease or Syndrome)", + "output": "cell-cell signalling involved in placenta development (Intercellular Communication Process)" + }, + { + "input": "Definition: Trunk of right coronary artery described as the opening of the right coronary artery at its origin.\nConcepts: 64Cu-NOTA-PSMA-PEG-Cy5.5-C' Dots (Indicator, Reagent, or Diagnostic Aid)\tErythrocyte Ankyrin (Amino Acid, Peptide, or Protein)\tRight Coronary Artery Ostium (Body Space or Junction)\tSinus pain (Sign or Symptom)\tHigh risk pregnancies (Finding of pattern of pregnancy)", + "output": "Right Coronary Artery Ostium (Body Space or Junction)" + }, + { + "input": "Definition: Diffuse large B-cell lymphoma recurrent described as the reemergence of intravascular large B-cell lymphoma after a period of remission.\nConcepts: response to drought (response to water)\tRecurrent Intravascular B-Cell Lymphoma (Angioendotheliomatosis)\tNilotic language (Language)\tStage IIIC Esophageal Adenocarcinoma AJCC v7 (Stage III Esophageal Adenocarcinoma AJCC v7)\tpositive regulation of mRNA decay (Molecular Function)", + "output": "Recurrent Intravascular B-Cell Lymphoma (Angioendotheliomatosis)" + }, + { + "input": "Definition: Pharmacologic Substance described as a monoclonal antibody directed against a specific tumor-associated antigen (TAA).\nConcepts: Shared Anti-Idiotype-AB-S025 (Immunologic Factor)\tasians (Asian - ethnic group)\tADSD Version 1.0 - Rate Breathing at Its Worst (ADSD Version 1.0 Questionnaire Question)\tScissors, Surgical, Brain (Surgical Scissors)\tBiophila wadsworthia (Bilophila)", + "output": "Shared Anti-Idiotype-AB-S025 (Immunologic Factor)" + }, + { + "input": "Definition: Cell Component described as a region at which the centric regions of polytene chromosomes are joined together.\nConcepts: Ectoderm cell (Colligocyte)\tanti-LOXL2 monoclonal antibody GS-6634 (Amino Acid, Peptide, or Protein)\tPontocerebellar hypoplasia type 2 (Brain Development Abnormality)\tpolytene chromosome chromocentre (Cell Component)\tEpistaxis (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)", + "output": "polytene chromosome chromocentre (Cell Component)" + }, + { + "input": "Definition: Audiometry, Speech described as a test to determine the lowest sound intensity level at which fifty percent or more of the spondaic test words (words of two syllables having equal stress) are repeated correctly.\nConcepts: TEST SRT (Audiometry, Speech)\tSyringes, Plunger, Catheter Tip, Aspiration/Irrigation (Medical Device)\tCongenital hematological disorder (Hematological Disease)\tPlannedCriterionGroupCompositionRelationship.pauseQuantity (Pause Quantity)\tcortical microtubule, transverse to long axis (Cell Component)", + "output": "TEST SRT (Audiometry, Speech)" + }, + { + "input": "Definition: Appendiceal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7 described as appendiceal carcinoma with metastasis in 1-3 regional lymph nodes.\nConcepts: ORDER CROCODILIA (Reptiles)\tAttenuation Correction Type (Quantitative Concept)\tCenersen (Antisense Oligonucleotides)\tGrade 1 Pleural Hemorrhage, CTCAE (Finding)\tAppendiceal Carcinoma pN1 TNM Finding v7 (Appendiceal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7)", + "output": "Appendiceal Carcinoma pN1 TNM Finding v7 (Appendiceal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Virus, Cytomegalovirus described as serology reagents intended to detect antibodies to cytomegalovirus (CMV), a DNA virus of the family Herpesviridae. Some types of CMV may cause a variety of diseases (i.e., cytomegalic inclusion diseases, leukemia) depending on the immune status and age of the host; persistence of the virus for the lifetime of the host is common.\nConcepts: ENZYMATIC METHOD, ALCOHOL DEHYDROGENASE, ULTRAVIOLET (Indicator, Reagent, or Diagnostic Aid)\tIVD Test Reagent/Kits, Serology, Virus, Cytomegalovirus, Antibody (IVD Test Reagent/Kits, Serology, Virus, Cytomegalovirus)\tpositive regulation of G-CSF production (positive regulation of macrophage colony-stimulating factor production)\tAble to See Well Enough without Correction (Clinical or Research Assessment Answer)\tSaws, Surgical, Bone, Electric, Reciprocating (Saws, Surgical, Bone, Electric)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Cytomegalovirus, Antibody (IVD Test Reagent/Kits, Serology, Virus, Cytomegalovirus)" + }, + { + "input": "Definition: something described as diseases of the fourth cranial (trochlear) nerve or its nucleus in the midbrain. The nerve crosses as it exits the midbrain dorsally and may be injured along its course through the intracranial space, cavernous sinus, superior orbital fissure, or orbit. Clinical manifestations include weakness of the superior oblique muscle which causes vertical DIPLOPIA that is maximal when the affected eye is adducted and directed inferiorly. Head tilt may be seen as a compensatory mechanism for diplopia and rotation of the visual axis. Common etiologies include CRANIOCEREBRAL TRAUMA and INFRATENTORIAL NEOPLASMS.\nConcepts: midlines (Spatial Concept)\tSGRQC1-Wheeze Worse in the Morning (Intellectual Product)\tmale germ-line stem cell asymmetric division (germline stem cell asymmetric division)\tNeuropathies, Trochlear (Disease or Syndrome)\tSEZCE (Lymphoma Cell Count)", + "output": "Neuropathies, Trochlear (Disease or Syndrome)" + }, + { + "input": "Definition: Disease or Syndrome described as abnormal passage communicating with the PANCREAS.\nConcepts: pancreatic fistula (pathologic fistula)\tmulti-organism localization (establishment and maintenance of localization)\tDictionary Name (Intellectual Product)\tXQZ (Country)\tintegrins (Receptor)", + "output": "pancreatic fistula (pathologic fistula)" + }, + { + "input": "Definition: Carbamate pesticide described as carbamate derivative used as an insecticide, acaricide, and nematocide.\nConcepts: Autologous vein graft (Body Part, Organ, or Organ Component)\tregulation of timing of neuron differentiation (regulation of neuron differentiation)\tAnti-EGFR CAR-transduced IL-12-expressing T-lymphocytes (Antineoplastic Immune Cell)\tCytomegalovirus Positive (Positive Laboratory Test Result)\tALDICARB (Hazardous or Poisonous Substance)", + "output": "ALDICARB (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: something described as the regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.\nConcepts: UHDR120 (UHDRS 1999 Version Clinical Classification Question)\tMixed Oligodendroglioma-Astrocytomas (Mixed Oligodendroglioma-Astrocytoma)\tdownregulation of monooxygenase activity (negative regulation of oxidoreductase activity)\tdorsal/ventral pattern formation (Organ or Tissue Function)\tBG (Intellectual Product)", + "output": "dorsal/ventral pattern formation (Organ or Tissue Function)" + }, + { + "input": "Definition: Hereditary Connective Tissue Disorder described as a subtype of junctional epidermolysis bullosa (JEB) with characteristics of skin and mucosal blistering, nail dystrophy or nail absence and enamel hypoplasia. Postinflammatory hypopigmentation or dyspigmentation may be striking in some patients. A generalised subtype with atrophic scarring and more extensive extracutaneous involvement has been described as well as a milder localised subtype. Caused by mutations in the COL17A1 (10q24.3) and LAMA3 (18q11.2), LAMB3 (1q32) and LAMC2 (1q25-q31) genes. The condition follows an autosomal recessive pattern of inheritance.\nConcepts: PerformedEligibilityCriterion.displayOrder (Display Order)\tPhysiologic Pressure Transducer Simulators (Physically-generated physiologic parameter simulator)\tEpidermolysis bullosa junctionalis, Disentis type (Disease or Syndrome)\tIntratendinous route (Parenteral Route of Drug Administration)\tmin.fg/mL/(mg/g) (Quantitative Concept)", + "output": "Epidermolysis bullosa junctionalis, Disentis type (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence.\nConcepts: RegulatoryApplication.typeCode (Intellectual Product)\tMucosal Melanoma of the Head and Neck pT4a TNM Finding v8 (Mucosal Melanoma of the Head and Neck pT4 TNM Finding v8)\tsidalcea glaucescens/mallow (Flower Essences)\tglyoxylate-glutamate aminotransferase activity (aminotransferase activity)\tclone cells (Cultured Cells)", + "output": "clone cells (Cultured Cells)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the injection of whole blood or a blood component directly into the bloodstream.\nConcepts: Molecular Fingerprint of Tumor (Molecular Signature)\tFibrobacter sp. (Fibrobacter)\tBlood transfusion (Medical & Physical Treatment)\tHOST CELL FACTOR C 001 (TRANSCRIPTION FACTOR)\tExocrine and Endocrine Pancreatic Cancer pM1 TNM Finding v7 (Exocrine and Endocrine Pancreatic Cancer Pathologic Distant Metastasis TNM Finding v7)", + "output": "Blood transfusion (Medical & Physical Treatment)" + }, + { + "input": "Definition: Bronchopulmonary Dysplasia, Adverse Event described as an adverse event in a newborn characterized by the need for supplemental oxygen at 28 days AND need for greater than 30% oxygen or positive pressure at 36 weeks postmenstrual age (PMA) in infants born less than 32 weeks' gestation; need for greater than 30% oxygen or positive pressure by 56 days postnatal age in infants born greater than 32 weeks' gestation; need for greater than 30% oxygen and/or positive pressure at discharge. Note: For conversion of oxygen administered by different modalities to fraction of inspired oxygen (FiO2): see http://nicutools.org/MediCalcs/ActualO2.php3.\nConcepts: positive regulation of peptide secretion (positive regulation of secretion)\tmelanins (Pigment cell)\tGrade 3 Bronchopulmonary Dysplasia, Adverse Event (Bronchopulmonary Dysplasia, Adverse Event)\tIDSR110 (IDS-SR Questionnaire Question)\tFamilial thrombotic thrombocytopenic purpura / haemolytic uraemic syndrome (Inherited platelet disorder)", + "output": "Grade 3 Bronchopulmonary Dysplasia, Adverse Event (Bronchopulmonary Dysplasia, Adverse Event)" + }, + { + "input": "Definition: Cardiovascular finding described as the creation of hematoma outside the arterial wall following bleeding due to puncture of the arterial wall. Pseudoaneurysms can also occur in the heart chambers following myocardial infarction and bleeding.\nConcepts: neonatal brachial plexus palsy (Brachial Plexus Neuropathies)\tAutosomal dominant Charcot-Marie-Tooth disease type 2J (Disease or Syndrome)\tIVD Test Reagent/Kits, Serology, Parasite, Fasciola hepatica, Antibody (IVD Test Reagent/Kits, Serology, Parasite)\timmunoadjuvant (Immunologic Factors)\tAneurysm, False (Aneurysm)", + "output": "Aneurysm, False (Aneurysm)" + }, + { + "input": "Definition: Recurrent Malignant Neoplasm described as the return of a malignancy, other than the original one, after a period of remission.\nConcepts: MIR183 Gene (Gene or Genome)\tNasal Cavity and Paranasal Sinuses Carcinoma pN2c TNM Finding v8 (Finding)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs TNM Finding v8 (Soft Tissue Sarcoma TNM Finding v8)\tRecurrent Subsequent Malignancy (Neoplastic Process)\tundef.nrse new inofc W nrsng (New client in-office with nursing diagnosis)", + "output": "Recurrent Subsequent Malignancy (Neoplastic Process)" + }, + { + "input": "Definition: something described as cell membrane glycoproteins that are selectively permeable to potassium ions.\nConcepts: Betaretrovirus (Orthoretrovirinae)\tPotassium Channels (Ion Channel)\tfluvoxaMINE (Obsessive compulsive disorder drugs)\tTuberculous pleural empyema (Thoracic Diseases)\tFAC071-Functional Subscale Score (Intellectual Product)", + "output": "Potassium Channels (Ion Channel)" + }, + { + "input": "Definition: Biospecimen described as a specimen obtained by biopsy, which is a process of removing tissue from living patients for diagnostic examination.\nConcepts: Objective Measurement (Finding)\tlipopolysaccharide 3-alpha-galactosyltransferase activity (UDP-galactosyltransferase activity)\tRASVAC-V (Immunologic Factor)\tGlioblastoma, no ICD-O subtype (Glioblastoma)\tbiopsy specimen (Biospecimen)", + "output": "biopsy specimen (Biospecimen)" + }, + { + "input": "Definition: Spatial Concept described as physical location of ANP32C_Gene\nConcepts: CDISC SEND Country Terminology (Intellectual Product)\tPeriosteal fibroma (Neoplastic Process)\tganglioneuroblastoma of central nervous system (Neoplastic Process)\tpretargeted radioimmunotherapy (Therapeutic or Preventive Procedure)\t4: 165476468-165475764 (Spatial Concept)", + "output": "4: 165476468-165475764 (Spatial Concept)" + }, + { + "input": "Definition: cyclase regulator activity described as modulates the activity of guanylate cyclase.\nConcepts: Type 0-I (Classification)\tOcclusion (Functional Concept)\tguanylate cyclase regulator activity (cyclase regulator activity)\tIFF/VNB (Therapeutic or Preventive Procedure)\tphosphoribosylaminoimidazole carboxylase complex (catalytic complex location)", + "output": "guanylate cyclase regulator activity (cyclase regulator activity)" + }, + { + "input": "Definition: Unknown Primary Tumor cN2 TNM Finding v8 described as unknown primary tumor with metastases in multiple ipsilateral cervical lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).\nConcepts: Unknown Primary Tumor cN2b TNM Finding v8 (Unknown Primary Tumor cN2 TNM Finding v8)\tRepair of eardrum (Tympanic membrane operation)\tSEND Implementation Guide Version (Version)\tAssay of citrate (biochemical test)\tNM 005228.3:c.1476C>A (Cell or Molecular Dysfunction)", + "output": "Unknown Primary Tumor cN2b TNM Finding v8 (Unknown Primary Tumor cN2 TNM Finding v8)" + }, + { + "input": "Definition: something described as the hydrochloride salt of mechlorethamine, a nitrogen mustard and an analogue of sulfur mustard, with antineoplastic and immunosuppressive activities. Mechlorethamine is metabolized to an unstable, highly reactive ethyleniminium intemediate that alkylates DNA, particularly the 7 nitrogen of guanine residues, resulting in DNA base pair mismatching, DNA interstrand crosslinking, the inhibition of DNA repair and synthesis, cell-cycle arrest, and apoptosis. This agent also exhibits lympholytic properties. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C627\" active clinical trials using this agent.\nConcepts: ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride (Nitrogen Mustard Antineoplastic Compounds)\tup-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria (regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria)\tMalfunction Only (No AE) Report (Report)\tviolaceol II degradation (catechol-containing compound catabolic process)\tWARMER, BLOOD, ELECTROMAGNETIC RADIATION (Medical Device)", + "output": "ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl Hydrochloride (Nitrogen Mustard Antineoplastic Compounds)" + }, + { + "input": "Definition: Infusion Pump described as a small device installed under the skin to provide long-term controlled-rate delivery of drugs such as chemotherapeutic agents or analgesics. Delivery rate may be externally controlled or osmotically or peristaltically controlled with the aid of transcutaneous monitoring.\nConcepts: Did you use a stimulant at least once a week or more often (Clinical or Research Assessment Question)\tRADIOIMMUNOASSAY, PREGNENOLONE (Indicator, Reagent, or Diagnostic Aid)\tCK2N (CSNK2B gene)\tAvailable For Evaluation Indicator (Indicator)\tImplantable infusion pump (Medical Device)", + "output": "Implantable infusion pump (Medical Device)" + }, + { + "input": "Definition: Health Care Activity described as a method of euthanasia whereby a subject is given a lethal intracardiac injection to induce death.\nConcepts: Orthoses, Lower Limb, Foot, Gait, Shoe Modifier, Extended Shank (Medical Device)\tLETHAL INJECTION INTRACARDIAC (Lethal Injection)\tInfluenza C viruses (Virus)\tVESICULAR GLUTAMATE TRANSPORT PROTEIN 01 (Biologically Active Substance)\tJuvenile systemic scleroderma (Systemic Scleroderma)", + "output": "LETHAL INJECTION INTRACARDIAC (Lethal Injection)" + }, + { + "input": "Definition: something described as an orally bioavailable pyrrolopyridine derivative and Smoothened (Smo) antagonist with potential antineoplastic activity. Smo antagonist TAK-441 selectively binds to and inhibits the activity Smo, which is a cell surface co-receptor for ligands in the Hedgehog (Hh) family. This may result in a suppression of Hh-mediated signaling pathways, thereby inhibiting the growth of tumor cells in which this pathway is aberrantly activated. Smo is a G-protein coupled receptor that lies just downstream of the Hh cell surface receptor Patched-1 in the Hh pathway; in the absence of ligand, Patched-1 (Ptch1) inhibits Smo, and ligand binding to Ptch1 results in increased levels of Smo. The Hh-mediated signaling pathways play an important role in cellular growth and differentiation, and tissue repair; constitutive activation of this pathway is associated with uncontrolled cellular proliferation in a variety of cancers.\nConcepts: ESRS-A - Akathisia: Objective (Intellectual Product)\toral hedgehog signaling pathway inhibitor TAK-441 (Organic Chemical)\tHSP90AA1 wt Allele (Gene or Genome)\tOncostatin M Receptor wt Allele (Gene or Genome)\tUnit of Angular Acceleration (Quantitative Concept)", + "output": "oral hedgehog signaling pathway inhibitor TAK-441 (Organic Chemical)" + }, + { + "input": "Definition: something described as providing a client/patient with travel related to his or her care, narrative required.\nConcepts: undef.pp srvc narr req'd (Therapeutic or Preventive Procedure)\tStage II Choroidal and Ciliary Body Melanoma (Neoplastic Process)\tCarrying out multiple tasks (Undertaking multiple tasks)\tClient-related travel narrative required (Extended services with or without ICD diagnosis)\tANIMAL RECORDS (Information)", + "output": "Client-related travel narrative required (Extended services with or without ICD diagnosis)" + }, + { + "input": "Definition: Cell Function described as an apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf.\nConcepts: non-professional antigen presenting cell antigen processing and presentation (Cell Function)\tepithelial cell apoptotic process involved in palatal shelf morphogenesis (Cell Function)\tCluster of differentiation antigen 55 (Immunologic Factor)\tstage IIB penile squamous cell carcinoma AJCC v8 (Neoplastic Process)\tsecretin human, synthetic (secretin)", + "output": "epithelial cell apoptotic process involved in palatal shelf morphogenesis (Cell Function)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a cytoarchitectural term denoting the layer of the CA fields that is deep to the pyramidal cell layer of the hippocampus and superficial to the alveus ( Stephan-1975 ).\nConcepts: Ectodermal dysplasia syndactyly syndrome (Multiple malformation syndrome with limb defect as major feature)\tINTERFERON-STIMULATED GENE, 43-KD (Cysteine Protease Genes)\tCatheters, Urinary, Foley (Sterile urethral catheters)\tNeurons, GABA (Neurons)\tOriens layer of hippocampus proper (Body Part, Organ, or Organ Component)", + "output": "Oriens layer of hippocampus proper (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: chondroitin sulfotransferase activity described as catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate.\nConcepts: 3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity (Molecular Function)\tCDISC Protocol Subject Allocation Response Terminology (Intellectual Product)\tHER2/Neu Status by Validated Dual-probe in Situ Hybridization (Molecular Biology Research Technique)\tVaginal Powder Dosage Form (Powder dose form)\tLASOFOXIFENE (Pharmacologic Substance)", + "output": "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity (Molecular Function)" + }, + { + "input": "Definition: Bodywork described as manipulating a client's soft tissue to identify abnormalities and restructure neural response(s) to normalize his or her muscle function. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.\nConcepts: Squalene (Indicator, Reagent, or Diagnostic Aid)\tCd (Cadmium and cadmium compound)\tNeuromuscular therapy each 15 minutes (Bodywork)\tResynchronization Defibrillator/Pacemakers (Medical Device)\tmUPD14 Syndrome (Disease or Syndrome)", + "output": "Neuromuscular therapy each 15 minutes (Bodywork)" + }, + { + "input": "Definition: BODY AS A WHOLE - GENERAL DISORDERS described as profuse sweating.\nConcepts: Fore-Brain (Cerebrum)\tGLIMEPIRIDE (Sulfonylureas for blood glucose lowering)\tStage IIB Colorectal Cancer (Neoplastic Process)\tSweating profusely (Hyperhidrosis disorder)\tMonoclonal Antibody COL-6 (Pharmacologic Substance)", + "output": "Sweating profusely (Hyperhidrosis disorder)" + }, + { + "input": "Definition: something described as the appearance of interferon-delta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\nConcepts: MicroRNA 21 wt Allele (MIR21 gene)\tinterferon-delta production (type I interferon production)\tChildhood Parosteal Osteogenic Sarcoma (Childhood Osteosarcoma)\tregulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase (Molecular Function)\tadolescent mother (Mother)", + "output": "interferon-delta production (type I interferon production)" + }, + { + "input": "Definition: SI unit of mass described as the metric unit of mass equal to one trillionth of a gram (10E-12 gram).\nConcepts: Picogram (Unit of mass)\tanti-CD19 immunotoxin (Immunotoxins)\tSyndrome (Hereditary Diseases)\tTortuosity of conjunctival vessels (Abnormal morphology of the conjunctival vasculature)\tRegional Perfusion Unit Heat Exchangers (Heat Exchangers)", + "output": "Picogram (Unit of mass)" + }, + { + "input": "Definition: positive regulation of axon regeneration described as any process that activates or increases the frequency, rate or extent of MAPK cascade involved in axon regeneration.\nConcepts: FACT-COG Version 3 - Able Remember to Do Things (Intellectual Product)\tCan Adjust to Things I Cannot Change (Clinical or Research Assessment Question)\tOral mucosa leukoplakia NOS (Disorder of oral soft tissues)\tStructured Product Labeling Shape Terminology (Intellectual Product)\tpositive regulation of MAPKKK cascade involved in axon regeneration (positive regulation of MAPK cascade)", + "output": "positive regulation of MAPKKK cascade involved in axon regeneration (positive regulation of MAPK cascade)" + }, + { + "input": "Definition: Hereditary disorder of musculoskeletal system described as an extremely rare fatal central nervous system malformation occurring during embryogenesis presenting prenatally on the ultrasound with holoprosencephaly and fetal hypokinesia as major features. Other manifestations include microcephaly, multiple contractures, intrauterine growth restriction. An X-linked recessive inheritance has been suggested.\nConcepts: Caldesmon 1 Gene (Gene or Genome)\tGland of third eyelid (EYES AND EYE APPENDAGES)\tHoloprosencephaly sequence with hypokinesia and congenital joint contracture syndrome (Genetic Diseases, X-Linked)\tAbility to walk in corridor (Ability to walk on the flat)\tDRRI-2 - M: Relationship With Spouse Ended (Intellectual Product)", + "output": "Holoprosencephaly sequence with hypokinesia and congenital joint contracture syndrome (Genetic Diseases, X-Linked)" + }, + { + "input": "Definition: something described as a subjective score of 6 on a difficulty falling asleep scale that ranges from 0: No difficulty to 10: Didn't fall asleep.\nConcepts: Grade 4 Small intestine ulcer (Finding)\tCATENIN, GAMMA (Gene or Genome)\tSafety Communications (Intellectual Product)\tDifficulty Falling Asleep Score 6 (Finding)\tIAP (Biologically Active Substance)", + "output": "Difficulty Falling Asleep Score 6 (Finding)" + }, + { + "input": "Definition: something described as transformation of chronic lymphocytic leukemia into aggressive non-Hodgkin's lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant). Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues. Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C35424\" active clinical trials using this agent.\nConcepts: Prevotella corporis (Johnson and Holdeman 1983) Shah and Collins 1990 emend. Hahnke et al. 2016 (Bacterium)\tFunctional Method (Osteopathic manipulation)\tenvironmental smoke tobacco (Tobacco smoke)\tRichter syndrome (Neoplastic disease)\tSWP73, YEAST, HOMOLOG OF (Gene or Genome)", + "output": "Richter syndrome (Neoplastic disease)" + }, + { + "input": "Definition: Genome Encoded Entity described as a primary RNA transcript synthesized from a DNA template in eukaryotic nuclei which is post-transcriptionally modified and spliced to produce a mature mRNA.\nConcepts: mRNA Precursor (Nucleic Acid, Nucleoside, or Nucleotide)\tPoint Mutations (Cell or Molecular Dysfunction)\tIMMUNOELECTROPHORETIC, IMMUNOGLOBULINS, (Medical Device)\tAlpha-2 macroglobulin (Drug measurement)\tProduct containing levobunolol (Phenoxypropanolamines)", + "output": "mRNA Precursor (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoma that arises from the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear.\nConcepts: Carcinoma;ear (Cancer of Ear)\tAqua pura / alchemical water (Homeopathic remedies letter A)\tNippostrongylus (Nippostrongylinae)\tStructured Product Labeling REMS Stakeholder Terminology (Intellectual Product)\tRNA interference, production of ta-siRNAs (Genetic Function)", + "output": "Carcinoma;ear (Cancer of Ear)" + }, + { + "input": "Definition: Benign Basal Cell Neoplasm described as a benign hair follicle neoplasm in the outer hair sheath and infundibulum, characterized by abrupt keratinization and central lumen with ghost cells.\nConcepts: amylin receptor complex location 3 (amylin receptor complex)\tBrevetoxin (Marine Toxins)\tCalcifying Epitherlioma of Malherbe (Benign Basal Cell Neoplasm)\tsharp chest pain (Sign or Symptom)\tDefined Imaging Contrast Agent Enhancement Indicator (Contrast Agent Enhancement Indicator)", + "output": "Calcifying Epitherlioma of Malherbe (Benign Basal Cell Neoplasm)" + }, + { + "input": "Definition: Stage III Diffuse Large B-Cell Lymphoma described as ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).\nConcepts: Control Agent, Biological (Biological Products)\tRing (Solid Dose Form)\tDNA DAMAGE-INDUCIBLE TRANSCRIPT 1 (Signaling Pathway Gene)\tStage III Mediastinal (Primary Mediastinal (Thymic) Large B-Cell Lymphoma by Ann Arbor Stage)\tEstrogen Replacement Therapy (Estrogen Therapy)", + "output": "Stage III Mediastinal (Primary Mediastinal (Thymic) Large B-Cell Lymphoma by Ann Arbor Stage)" + }, + { + "input": "Definition: RoleClassRelationshipFormal described as a native or naturalized member of a state or country, especially one entitled to vote and enjoy other privileges there.\nConcepts: citizen (RoleClassRelationshipFormal)\tProtein, ras (Monomeric GTP-Binding Proteins)\tbenzene 1,2-dioxygenase activity (Molecular Function)\tC3H/HeJ Mouse (Mice, Inbred Strains)\tRadioactive Technetium/Carbon Particle Encapsulated Gas Generators (Radiology/Radiation Therapy Equipment and Supplies)", + "output": "citizen (RoleClassRelationshipFormal)" + }, + { + "input": "Definition: Sequence Homology, Amino Acid described as the degree of 3-dimensional shape similarity between proteins. It can be an indication of distant AMINO ACID SEQUENCE HOMOLOGY and used for rational DRUG DESIGN.\nConcepts: bidens connata/beggars tick/ (Bidens)\tsmall Cajal body-specific RNA 19 (Gene or Genome)\tPaclitaxel/Ramucirumab (Regimen Used to Treat Gastric Carcinoma)\tScorpaeniformes (Class osteichthyes - bony fish)\tProtein Structural Homologies (Protein Conformation)", + "output": "Protein Structural Homologies (Protein Conformation)" + }, + { + "input": "Definition: something described as a chromosome band present on 4q\nConcepts: 21D Tab (Tablet Dosage Form)\tSexual Maturity Status at Neutering (Finding)\tNEW MYOCARDIAL INFARCTION (Finding)\t4q21.1 (Chromosome band)\tcarcinoma pancreatic (Pancreatic neoplasms malignant)", + "output": "4q21.1 (Chromosome band)" + }, + { + "input": "Definition: Temporal Concept described as every two weeks.\nConcepts: alphaIIb-beta3 integrin-talin complex (plasma membrane protein complex)\tSmoothened antagonist LDE225 topical (Organic Chemical)\tQ2S (Schedule Frequency)\tSite of New Distant Metastasis Tumor Event (CPTAC Questions)\tBcr-Abl (b2a2)-Derived Peptide Vaccine (Immunologic Factor)", + "output": "Q2S (Schedule Frequency)" + }, + { + "input": "Definition: something described as lip and oral cavity cancer with distant metastasis.\nConcepts: Soft Palate Benign Granular Cell Tumor (Benign neoplasm of soft palate)\tAnimal.strain (Organism Strain)\tStructure of anterior cardiac vein (Veins)\tLip and Oral Cavity Carcinoma cM1 TNM Finding v8 (Finding)\tMDI (Intellectual Product)", + "output": "Lip and Oral Cavity Carcinoma cM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Genetic Function described as any process that activates or increases the frequency, rate or extent of reverse transcription.\nConcepts: negative regulation of protein targeting to membrane (negative regulation of protein localization to membrane)\tup-regulation of ductus arteriosus closure (Organ or Tissue Function)\tupregulation of reverse transcription (positive regulation of DNA biosynthetic process)\tInvestigational (Qualitative Concept)\to-Dihydroxybenzenes (Organic Chemical)", + "output": "upregulation of reverse transcription (positive regulation of DNA biosynthetic process)" + }, + { + "input": "Definition: Qualitative Concept described as describes something that causes the blood vessels to constrict (get narrower) or dilate (get wider).\nConcepts: vasoactive (Active)\tKidney Neuroendocrine Neoplasm (Neuroendocrine Tumors)\tAMA-M2 Measurement (Immunologic Tests)\tdigestions (Gastrointestinal Process)\tregulation of progesterone biosynthesis (regulation of hormone biosynthetic process)", + "output": "vasoactive (Active)" + }, + { + "input": "Definition: something described as a bacteriostatic antibiotic with activity against Gram-positive bacteria. Clofoctol is used in the treatment of upper and lower respiratory tract infections.\nConcepts: GEMTUZUMAB (Pharmacologic Substance)\toctofene (C [Preparations])\tPatent ductus arteriosus, bicuspid aortic valve, hand anomaly syndrome (Finding of bone in hand)\tProminent xiphoid process (Abnormality of the xiphoid process)\t(2S,5S)-2,5-diamino-6-[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]hexanoic acid (Antifungal Agents)", + "output": "octofene (C [Preparations])" + }, + { + "input": "Definition: dibenzodiazepines described as a selective blocker of DOPAMINE D2 RECEPTORS and SEROTONIN 5-HT2 RECEPTORS that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of SCHIZOPHRENIA.\nConcepts: Mouse Teratocarcinoma (Neoplastic Process)\tFocal emotional seizure with fear/anxiety/panic (Disease or Syndrome)\tStage II Vulvar Cancer AJCC v8 (Vulvar Cancer by AJCC v8 Stage)\tNumeric Country Code (Country Code)\t4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl- (Pharmacologic Substance)", + "output": "4H-Pyrido(1,2-a)pyrimidin-4-one, 3-(2-(4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl)ethyl)-6 ,7,8,9-tetrahydro-2-methyl- (Pharmacologic Substance)" + }, + { + "input": "Definition: nucleoside monophosphate kinase activity described as catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.\nConcepts: uridylate kinase activity (nucleoside monophosphate kinase activity)\tPROSTHESIS, SHOULDER, SEMI-CONSTRAINED, METAL/POLYMER CEMENTED (Medical Device)\tDermatophylus congolense (Bacterium)\tHepatitis B Antigens (Antigens)\tmodulation of transcription in other organism involved in symbiotic interaction (modulation of process of other organism involved in symbiotic interaction)", + "output": "uridylate kinase activity (nucleoside monophosphate kinase activity)" + }, + { + "input": "Definition: Histone H2A Gene described as this gene is involved in cellular functions that are modulated by the histone code.\nConcepts: Gossypibomas (Inflammatory Myofibroblastic Tumor)\txenobiotics (Hazardous or Poisonous Substance)\tPromotion of Health (Counseling)\ttoluate dioxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor)\tH2AW (Histone H2A Gene)", + "output": "H2AW (Histone H2A Gene)" + }, + { + "input": "Definition: something described as application of the beneficial effects of drugs to control or cure neoplastic growth.\nConcepts: neoplasm pharmacotherapy (Therapeutic or Preventive Procedure)\tpeptidyl-tryptophan oxidation to tryptophyl quinone (protein oxidation)\tRetinal arterial tortuosity (Arterial tortuosity)\tImportance Score 0 (10-Point Importance Scale)\tRenal Papilla (Set of inner region of renal pyramids)", + "output": "neoplasm pharmacotherapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Aminoquinoline antimalarial described as the prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.\nConcepts: Erythrocyte sedimentation rate (ESR) abnormal (Haematological analyses NEC)\tMechanic, Breathing (Respiration)\tplacental protein 13, human (Phospholipase)\tstethoscopes (Medical Device)\tCHLOROQUINE (Amebicides)", + "output": "CHLOROQUINE (Amebicides)" + }, + { + "input": "Definition: Organic Chemical described as a second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, glisoxepide exerts greater binding affinity than the first-generation compounds. Glisoxepide shows peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity, has a short half-life and is excreted in both the bile and urine. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C72801\" active clinical trials using this agent.\nConcepts: MAF Gene (Gene or Genome)\tGlisoxepide (Organic Chemical)\tSNP ID (Intellectual Product)\tcaprate dehydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tbenzazepines (Pharmacologic Substance)", + "output": "Glisoxepide (Organic Chemical)" + }, + { + "input": "Definition: something described as underdevelopment of the trapezium.\nConcepts: Small trapezium (Abnormality of the trapezium)\tCDKN2A c.89C>T (Cell or Molecular Dysfunction)\tM2 Macrophage (Cell)\tSyndromic microphthalmia type 10 (Brain Diseases)\tHeart Sound Auscultation at Left Axilla (Finding)", + "output": "Small trapezium (Abnormality of the trapezium)" + }, + { + "input": "Definition: something described as elevated concentration of SO4(2-), i.e., sulfate, in the urine.\nConcepts: PIVAMPICILLIN PROBENATE (penicillins)\tDRRI-2 - F: Exposed to Nuclear Weapons (DRRI-2 Questionnaire Question)\tBreast Fluids and Secretions (Body Substance)\tADTC0103 (AUDIT-C Questionnaire Question)\tIncreased urinary sulphate (Abnormal urinary sulfate concentration)", + "output": "Increased urinary sulphate (Abnormal urinary sulfate concentration)" + }, + { + "input": "Definition: Needle device described as needles designed to pass a suture filament or fine wire underneath a blood vessel or to other tissues or body parts (e.g., tumor pedicle) to tie, bind, or partially strangulate it. These devices consist of a slender steel needle with a long handle and a curved end with an eye and a sharp or blunt tip appropriate to handle the ligatures. Ligature needles are available both for right and left handed surgeons. Stronger ligatures with a bigger diameter are usually manipulated using ligature passers (also known as ligature carriers).\nConcepts: Grade 3 Hearing impaired (Hearing Impaired, CTCAE)\tNeedles, Ligature (Medical Device)\tglycoprotein network (cellular anatomical entity)\tSkin Test Domain (Intellectual Product)\tCDISC SDTM Pharmaceutical Dosage Form Terminology (CDISC SDTM Terminology)", + "output": "Needles, Ligature (Medical Device)" + }, + { + "input": "Definition: Finding described as a finding of no labial escape during swallowing.\nConcepts: Proto-Oncogene Pim-2 (Serine Threonine Kinase) Gene (PIM2 gene)\tKnob Device (Manufactured Object)\tNo Labial Escape (Impairment of Lip Closure)\tCRS1 (Chemotherapy Response Score)\tAryl sulphotransferase (Enzyme)", + "output": "No Labial Escape (Impairment of Lip Closure)" + }, + { + "input": "Definition: something described as a lack of bone mineralization of one or more body of cervical vertebra.\nConcepts: 3: 50624207-50618930 (Spatial Concept)\tgeraniol 10-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tOchotonidae (Mammal)\tDRRI-2 - K: Made Crude Sexual Remarks at Me (Intellectual Product)\tAbsent ossification of cervical vertebral bodies (Absent or minimally ossified vertebral bodies)", + "output": "Absent ossification of cervical vertebral bodies (Absent or minimally ossified vertebral bodies)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 12q\nConcepts: 2-ketoglutarate metabolic process (dicarboxylic acid metabolic process)\thRAD54 (Gene or Genome)\tTwin Studies (Intellectual Product)\t12q22-q23 (Chromosome band)\tsperm chromatin condensation (cellular process involved in reproduction in multicellular organism)", + "output": "12q22-q23 (Chromosome band)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) In the past 4 weeks, did the subject use a household appliance to do chores?\nConcepts: Skin of hand and finger, NOS (Skin of part of hand)\trnax teach about safe sex practices (Public health service)\tVerbal Reinforcements (Reinforcement, Social)\tStimulators (Monitor, alarm AND/OR stimulator)\tADL01-Use Household Appliance (ADCS-ADL Questionnaire Question)", + "output": "ADL01-Use Household Appliance (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of the symbiont or its cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting molecules of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Lumicolchicines (colchicine)\tresponse to host (Cell Function)\tgallopamil (Class IV antiarrhythmic agent)\tNatural Rubber Latex (Industrial and household substance)\tMRL lpr Mice (Mammal)", + "output": "response to host (Cell Function)" + }, + { + "input": "Definition: Enzyme Inhibitors described as the free base form of a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cycle arrest by preventing phosphorylation of cyclin-dependent kinases (CDKs) and by down-regulating cyclin D1 and D3 expression, resulting in G1 cell cycle arrest and apoptosis. This agent is also a competitive inhibitor of adenosine triphosphate activity.\nConcepts: PEG3 (Imprinting Gene)\t(-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one (Pharmacologic Substance)\tGenus Elizabethkingia (Flavobacteriaceae)\ttrans-lignocero-2-enoyl-CoA reductase activity (Molecular Function)\tStage I Differentiated Thyroid Gland Carcinoma 45 Years and Older AJCC v7 (Stage I Differentiated Thyroid Gland Carcinoma AJCC v7)", + "output": "(-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as enables the transmembrane transfer of a calcium ion by a channel that opens when cyclic adenosine diphosphate ribose (cADPR) has been bound by the channel complex or one of its constituent parts.\nConcepts: Ovarian Vein (Lateral half of abdominopelvic structure)\tcADPR-sensitive calcium-release channel activity (calcium-release channel activity)\tFLJ40451 (Gene or Genome)\tIsolated Glucocorticoid Deficiency (Hereditary disorder of endocrine system)\tP450C2D (CYP2D6 gene)", + "output": "cADPR-sensitive calcium-release channel activity (calcium-release channel activity)" + }, + { + "input": "Definition: something described as an indication or description that a healthcare encounter was previously determined, characterized, or detailed.\nConcepts: Healthcare Encounters Pre-specified (Pre-specified)\tDyskeratosis congenita syndrome (Ectodermal Dysplasia)\ttherapeutic blood vessel occlusion (Cardiovascular Surgical Procedures)\tMiniature pinscher dog (Dog family)\tursodeoxycholate (U [Preparations])", + "output": "Healthcare Encounters Pre-specified (Pre-specified)" + }, + { + "input": "Definition: Immunoregulation described as renewed rapid production of an antibody on the second (or subsequent) encounter with the same antigen.\nConcepts: Schedule I Substance (Schedule of Controlled Substances)\tMemory Dysfunction (Mental disorders)\tImmunological Memories (Immune System Processes)\tCobra venom (Vaccines and Antiserums)\tIlleal Lipid-Binding Protein (Biologically Active Substance)", + "output": "Immunological Memories (Immune System Processes)" + }, + { + "input": "Definition: something described as the anhydrous form of piperacillin, a broad-spectrum semisynthetic ureidopenicillin antibiotic. Piperacillin binds to penicillin binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, cell wall synthesis is interrupted leading to a weakened cell wall and eventually cell lysis.\nConcepts: PIPERACILLIN ANHYDROUS (Acylaminopenicillin)\tEN - Erythema nodosum (Inflammation of specific body structures or tissue)\tAbnormality of the intermaxillary bone (Anatomical Abnormality)\tGenus Cercocebus (Mammal)\tBCL2-LIKE 9 (Apoptosis Promoter Gene)", + "output": "PIPERACILLIN ANHYDROUS (Acylaminopenicillin)" + }, + { + "input": "Definition: something described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Self-Administered Format - How much time did you usually spend walking on one of those days?: minutes per day.\nConcepts: Multiple chromosomal breaks (LABORATORY ABNORMALITIES)\tSpermatic cord obstruction (Reproductive System and Breast Disorders, CTCAE)\tInfluenza A Virus, H3N2 Subtype (Virus)\tIPA0406B (IPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question)\tamine biosynthesis (cellular nitrogen compound biosynthetic process)", + "output": "IPA0406B (IPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question)" + }, + { + "input": "Definition: something described as general management of a hospital, or the more specific processes involved in the management of an individual department.\nConcepts: lanolin (Pharmacologic Substance)\tEuthyroid Condition (Disease or Syndrome)\tHOSP ADMIN (Health Facility Administration)\tTAC1 Gene Product (Biologically Active Substance)\tsediment urine (Sediment)", + "output": "HOSP ADMIN (Health Facility Administration)" + }, + { + "input": "Definition: Adenovirus Vaccine described as a recombinant replication-defective adenovirus which encodes the gene for the cytokine human interferon-beta (IFN-beta). Once inserted into and replicating in host tumor cells, recombinant adenovirus-hIFN-beta expresses human IFN-beta, which may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce caspase-mediated tumor cell apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28550\" active clinical trials using this agent.\nConcepts: Non-Parameningeal Head and Neck Area (Head and Neck Part)\tVulva Intraepithelial Neoplasia (Lesion of vulva)\testablishment of planar polarity of follicular epithelium (establishment or maintenance of polarity of follicular epithelium)\tcollagen/aloe vera/vitamin E/lidocaine topical hydrogel (Clinical Drug)\tRecombinant Adenovirus-hIFN-beta (Pharmacologic Substance)", + "output": "Recombinant Adenovirus-hIFN-beta (Pharmacologic Substance)" + }, + { + "input": "Definition: Examination of nail described as deeply placed nails.\nConcepts: nails deep-set (Nail plate)\tJopamidol (Benzoate derivative)\tEndogenous Thrombin Potential Lag Time Measurement (Blood coagulation tests)\tNeutron radiation (Heavy particle radiation)\tReady for enhanced family processes (General clinical state finding)", + "output": "nails deep-set (Nail plate)" + }, + { + "input": "Definition: Regimen Used to Treat Kaposi Sarcoma described as a chemotherapy regimen consisting of thalidomide that may be used in the treatment of AIDS-related Kaposi sarcoma.\nConcepts: Thalomid Regimen (Therapeutic or Preventive Procedure)\tpN0(i+) Carcinoma of Breast v6 (Finding)\tWhat did you take (Clinical or Research Assessment Question)\tDigoxin - chemical (Cardiac Glycoside [EPC])\theparin catabolism (sulfur compound catabolic process)", + "output": "Thalomid Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a solitary fibrous tumor that arises from the bladder. Most tumors are benign.\nConcepts: SARCOMA (neoplasm/cancer type)\tregulation of system process (Biologic Function)\tchlorophyllide-a:geranyl-geranyl diphosphate geranyl-geranyl transferase activity (Molecular Function)\tMUNC18-2 protein, human (Carrier Proteins)\tBladder Solitary Fibrous Tumor (Bladder Soft Tissue Neoplasm)", + "output": "Bladder Solitary Fibrous Tumor (Bladder Soft Tissue Neoplasm)" + }, + { + "input": "Definition: Biologically Active Substance described as neural cell adhesion molecule 1 (761 aa, ~84 kDa) is encoded by the human NCAM1 gene. This protein is involved in the mediation of neuron-neuron adhesion.\nConcepts: Tragion (Body Location or Region)\tTrial Documents (Intellectual Product)\tPAM complex location (Cell Component)\tCD56 Antigen (Biologically Active Substance)\tlymphangioma (Lymphangioma)", + "output": "CD56 Antigen (Biologically Active Substance)" + }, + { + "input": "Definition: something described as published by the US Veterans' Administration. National Drug File Reference Terminology covers clinical drugs used at the VA.\nConcepts: US Department of Veterans Affairs National Drug Formulary Reference Terminology (Information Resources)\tFAC07116 (Intellectual Product)\tMSNGMTRX (Laboratory Procedure)\tCenters, Respiratory (Body Part, Organ, or Organ Component)\tPediatric Nodular Lymphocyte Predominant Hodgkin's Disease (Neoplastic Process)", + "output": "US Department of Veterans Affairs National Drug Formulary Reference Terminology (Information Resources)" + }, + { + "input": "Definition: Qualitative Concept described as awareness of, or attitudes toward, potential risk. Primarily used for risk associated with disease or behavior.\nConcepts: pancreatic D cell differentiation (Cell Function)\tperception of risk (safe and unsafe behavior)\tInferior mesenteric arterial tree (Systemic arterial tree)\tBendamustine/Ara-C (Regimen Used to Treat Non-Hodgkin Lymphoma)\tIVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Urine, Single Analyte (Medical Device)", + "output": "perception of risk (safe and unsafe behavior)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is or was afraid the treatment may harm their body.\nConcepts: Ineffective esophageal peristalsis (Finding)\tHot flashes (Intellectual Product)\tAfraid Treatment May Harm Body (Intellectual Product)\tpleated septate junction (Cell Component)\tGait Disturbance (Finding)", + "output": "Afraid Treatment May Harm Body (Intellectual Product)" + }, + { + "input": "Definition: Radical perineal prostatectomy described as surgery to remove all of the prostate through an incision between the scrotum and the anus. Nearby lymph nodes are sometimes removed through a separate incision in the wall of the abdomen.\nConcepts: Radical perineal prostatectomy (Radical perineal prostatectomy)\tglandula tarsales development (Organ or Tissue Function)\tNEUTGT (Neutrophil count)\tMaxillary Sinus Cancer pTis TNM Finding (Finding)\tanaerobic phenol-containing compound degradation (phenol-containing compound catabolic process)", + "output": "Radical perineal prostatectomy (Radical perineal prostatectomy)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as the value obtained from condensing three replicate measures using a strategy provided by GeneData Screener software.\nConcepts: Materials--Testing (Investigative Techniques)\tcytokine biosynthetic process involved in immune response (Molecular Function)\tCondensed Activity (Numerical value)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Adenovirus, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Adenovirus)\ttrue vocal cords impaired mobility bilateral cord paralysis (Vocal Cord Paralysis)", + "output": "Condensed Activity (Numerical value)" + }, + { + "input": "Definition: regulation of basement membrane assembly involved in embryonic body morphogenesis described as any process that activates or increases the frequency, rate or extent of basement membrane assembly involved in embryonic body morphogenesis.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Rapid Test, Toxicology, Antidepressant (Medical Device)\tnegative regulation of transmembrane receptor protein serine/threonine kinase signalling pathway (regulation of transmembrane receptor protein serine/threonine kinase signaling pathway)\tup-regulation of basement membrane assembly involved in embryonic body morphogenesis (positive regulation of extracellular matrix assembly)\tIncrease in fiber content of the diet compared to the assessed baseline intake of fiber for the individual. (Modified basic hospital diet)\tGelatinase (Metalloendopeptidases)", + "output": "up-regulation of basement membrane assembly involved in embryonic body morphogenesis (positive regulation of extracellular matrix assembly)" + }, + { + "input": "Definition: Enzyme Replacement or Supplement Agent described as a drug used to treat acute lymphoblastic leukemia (ALL). It is a form of the drug asparaginase that is linked to a substance called PEG, which makes the drug stay in the body longer. Asparaginase is an enzyme that breaks down the amino acid asparagine and may block the growth of tumor cells that need asparagine to grow. It is a type of protein synthesis inhibitor.\nConcepts: Ann Arbor Stage II Lymphoma (Lymphoma stage finding)\tTreadmill Exercisers (Exerciser)\tPegaspargase (Hydrolase)\tRegulatory Assessment Date (Temporal Concept)\tCutaneous Melanoma cM1a(1) TNM Finding v8 (Cutaneous Melanoma cM1a TNM Finding v8)", + "output": "Pegaspargase (Hydrolase)" + }, + { + "input": "Definition: positive regulation of cell activation described as any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation.\nConcepts: Stratum Group Number (Intellectual Product)\tAbsent end part of the outermost bone of the big toe (Abnormality of the epiphysis of the distal phalanx of the hallux)\tpositive regulation of hepatic stellate cell activation (regulation of hepatic stellate cell activation)\tassistive devices technology (biomedical engineering field)\tregulation of extent of heterochromatin assembly (regulation of heterochromatin assembly)", + "output": "positive regulation of hepatic stellate cell activation (regulation of hepatic stellate cell activation)" + }, + { + "input": "Definition: 14q partial trisomy syndrome described as a rare chromosomal anomaly characterized by developmental delay, mild to severe intellectual disability with speech impairment and epilepsy. Additionally, it may include dysmorphic features (such as hypo or hypertelorism, dysplastic ears, short palpebral fissures), microcephaly or macrocephaly, behavioral abnormalities, stereotyped hand movements, ataxia, hypotonia, cleft palate.\nConcepts: Trisomy 14q11.2 (Disease or Syndrome)\tBasement Membranes (Epithelium proper of esophagus)\t9,10-dihydroxybenzo(a)pyrene dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tRegio pubica (Structure of subregion of abdomen)\tactivation of store-operated calcium channel activity (Cell Function)", + "output": "Trisomy 14q11.2 (Disease or Syndrome)" + }, + { + "input": "Definition: something described as treatment using more than one anticancer drug.\nConcepts: Listeria welshimeri (Listeria)\tRNASE3L Gene Mutation (Cell or Molecular Dysfunction)\t0.5 L (Quantitative Concept)\tChemotherapy, Combination (Therapeutic or Preventive Procedure)\tRituximab Plus Hyper-CVAD Alternating with R-Methotrexate/Cytarabine (Therapeutic or Preventive Procedure)", + "output": "Chemotherapy, Combination (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a benign breast neoplasm characterized by the proliferation of multiple papillomas within the lumen of the ducts.\nConcepts: DYNAMIC SUSCEPTIBILITY-CONTRAST MRI (Magnetic Resonance Imaging)\tIntraductal Papillomatosis of the Breast (Breast Papillomatosis)\tTransition Dyspnea Index Clinical Classification (Clinical Classification)\tAnalog, Nucleoside (Pharmacologic Substance)\tZopiclonum (Pharmaceutical Preparations)", + "output": "Intraductal Papillomatosis of the Breast (Breast Papillomatosis)" + }, + { + "input": "Definition: Vulvar Cancer by AJCC v6 Stage described as stage IV includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0); IVB (Any T, Any N, M1). T4: Tumor invades any of the following: upper urethra bladder mucosa, rectal mucosa, or is fixed to the pubic bone. N2: Bilateral regional lymph node metastasis. M1: distant metastasis (including pelvic lymph node metastasis).\nConcepts: response to 5-fluoro-2'-deoxyuridine (response to antineoplastic agent)\tH2A Clustered Histone 15 Gene (Gene or Genome)\tStage IV Vulvar Cancer (Vulvovaginal cysts and neoplasms)\tKelch-Like ECH-Associated Protein 1 Gene Alteration Positive (Laboratory or Test Result)\tLaryngeal Carcinoma by AJCC v6 Stage (Carcinoma of larynx)", + "output": "Stage IV Vulvar Cancer (Vulvovaginal cysts and neoplasms)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is afraid that their children would have a high chance of getting cancer.\nConcepts: Stage III Keratinizing Squamous Cell Carcinoma of the Nasopharynx (Stage III Nasopharyngeal Carcinoma)\tDisease Steps Clinical Classification Test Code (CDISC Clinical Classification Terminology)\tday*ug/mL/m2 (Measurement Unit Description)\tI am afraid my children would have a high chance of getting cancer (Clinical or Research Assessment Question)\tBarium product (Elements, Ions and Simple Compounds)", + "output": "I am afraid my children would have a high chance of getting cancer (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the long ascending sensory pathways located lateral to the reticular formation of the brainstem. They include the medial lemniscus of the midbrain, the medial lemniscus of the pons, the medial lemniscus of the medulla, the lateral lemniscus, the spinothalamic tract, the dorsal trigeminal tract, the ventral trigeminal tract and the spinal trigeminal tract ( Carpenter-1983 ).\nConcepts: Peptide Hormone Measurement (Drug Class Measurement)\tlemniscal system (Afferent Pathways)\tStudy Personnel (Research Personnel)\tPremature breast development at puberty (Finding related to development of the breasts)\tattachment of spindle microtubules to mitotic chromosome (mitotic cell cycle process)", + "output": "lemniscal system (Afferent Pathways)" + }, + { + "input": "Definition: Globulin level - finding described as a measurement of the thyroxine binding globulin protein in a biological specimen.\nConcepts: Anti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704 (Pharmacologic Substance)\tTBG - Thyroxine binding globulin level (Thyroid Function Tests)\tN Terminal Acetyltransferase Type B (peptide N-alpha acetyltransferase)\tNCI Program (Governmental or Regulatory Activity)\tAbelson-Related Gene Protein (Amino Acid, Peptide, or Protein)", + "output": "TBG - Thyroxine binding globulin level (Thyroid Function Tests)" + }, + { + "input": "Definition: Street Drugs described as a highly addictive form of cocaine that is either smoked, injected intravenously, or orally ingested.\nConcepts: Aqueous chamber (Anterior eyeball segment structure)\tOrthoses, Lower Limb, Knee-Ankle-Foot, Therapeutic, Infant Bowleg, Static Brace (Orthoses, Lower Limb, Knee-Ankle-Foot, Therapeutic, Infant Bowleg)\tcrack cocaine (Psychostimulant)\tPulse Wave Amplitude Measurement (ACC-AHA Measure)\tDAEC (Enteroadherent Escherichia coli)", + "output": "crack cocaine (Psychostimulant)" + }, + { + "input": "Definition: Findings values described as not known\nConcepts: glucose catabolic process to lactate and acetate (glucose catabolic process)\tIn the past 7 days, did you miss an expected menstrual period (Intellectual Product)\tundetermined (Qualitative Concept)\tmethanopterin metabolism (organophosphate metabolic process)\tTSCYC1-Very Angry Over a Little Thing (Intellectual Product)", + "output": "undetermined (Qualitative Concept)" + }, + { + "input": "Definition: Placenta and umbilical cord described as increased size of the placenta.\nConcepts: Stains, Electron Microscopy (IVD Test Reagent/Kits)\tgossip (Personal Communication)\tBreast tumors of unspecified malignancy (Classification)\tRecurrent Adenoid Cystic Carcinoma of Oral Cavity (Recurrent Adenoid Cystic Carcinoma)\tLarge placenta (Placenta size)", + "output": "Large placenta (Placenta size)" + }, + { + "input": "Definition: Body Space or Junction described as region of posterior wall of prostatic part of urethra, each instance of which is a posterolateral recess between the urethral crest and the wall of some urethra, where the prostatic ductules empty into the urethra.\nConcepts: Sinus prostaticus (Segment of prostatic urethra)\tPressure Relief Pads, Air (Decubitis Care Equipment)\tSoft Tissue Sarcoma pT0 TNM Finding v7 (Finding)\tTrypanosoma sp. (Subphylum Mastigophora)\tcytoplasmic streaming (Biological Transport)", + "output": "Sinus prostaticus (Segment of prostatic urethra)" + }, + { + "input": "Definition: Cell described as a preparation of genetically modified autologous T-cells transduced with a replication incompetent, self-inactivating lentiviral vector expressing a fourth generation chimeric antigen receptor (4SCAR) consisting of an anti-CD22 single chain variable fragment (scFv) that is coupled to the costimulatory signaling domains CD28, CD137, CD27 and the zeta chain of the T-cell receptor (TCR), and is fused with the suicide gene inducible caspase 9 (iCasp9), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, autologous CD22-4SCAR-expressing T-cells 4SCAR22 are directed to and induce selective toxicity in CD22-expressing tumor cells. iCasp9 consists of a human FK506 drug-binding domain with an F36V mutation (FKBP12-F36V) linked to human caspase 9. If the administered T-cells lead to unacceptable side effects, the chemical homodimerizer AP1903 can be administered. AP1903 binds to the drug binding FKBP12-F36V domain and induces activation of caspase 9, which results in the apoptosis of the administered T-cells and enhances safety of this agent. CD22, a B-lineage-restricted, transmembrane phosphoglycoprotein, is expressed on malignant B cells. CD28, CD137 and CD27, T-cell surface-associated co-stimulatory molecules, are required for full T-cell activation and enhance both proliferation of T-cells and antitumor activity.\nConcepts: 4SCAR22 (Antineoplastic Immune Cell)\tFLUOROCHOLINE F-18 (Fluorine Compounds)\tbacterial-type flagellum stator complex location (integral component of plasma membrane)\tPackage Dosing Unit (Unit dose)\tInterleukin 1 Beta (Immunologic Tests)", + "output": "4SCAR22 (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Metal and metallic compound described as a colorless, volatile and highly flammable, liquid inorganic compound with a characteristic, musty odor that emits toxic carbon monoxide fumes upon heating. Nickel carbonyl is primarily used for nickel coatings and to manufacture high-purity nickel powder. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel carbonyl is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers.\nConcepts: Nickel tetracarbonyl (Nickel compound)\tresponse to 5-fluorouracil (response to xenobiotic stimulus)\tanti-alpha 5 beta 1 integrin monoclonal antibody (Pharmacologic Substance)\ttri-virus/GD2-specific allogeneic cytotoxic T-lymphocytes (Allogeneic Lymphocyte)\tPain in the pharynx (Finding of head and neck region)", + "output": "Nickel tetracarbonyl (Nickel compound)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(1;22)(p13;q13) which fuses the 5' portion of the MKL1 gene to the 3' portion of the RBM15 gene. This rearrangement is associated with infantile acute megakaryoblastic leukemia.\nConcepts: MKL1/RBM15 Fusion Gene (Fusion Gene)\t1q22-q24 (Chromosome band)\tHow Often Feel Sexually Attractive When Unclothed (Intellectual Product)\tWest Haven Hepatic Encephalopathy Grade 0 (West Haven Criteria - West Haven Hepatic Encephalopathy Grade)\tpostsynapse biogenesis (Cell Function)", + "output": "MKL1/RBM15 Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Bar form described as a solid dosage form usually in the form of a rectangle that is meant to be chewed.\nConcepts: RETRO (Parenteral Route of Drug Administration)\tpyrimidine nucleoside transport (nucleoside transport)\tblastocysti hominis (Eukaryote)\tIsomerase (Isomerase)\tChewable Bar Dosage Form (Biomedical or Dental Material)", + "output": "Chewable Bar Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Fungi/Yeast described as serology reagents intended to detect antibody titers or antigens to Pneumocystis jiroveci (formerly known as Pneumocystis carinii sp. hominis), yeast-like imperfect fungi of the family Pneumocystidaceae. P. jiroveci is an opportunistic pathogen of the respiratory tract, especially in immunocompromised patients.\nConcepts: Scavenger Receptors, Class D (Amino Acid, Peptide, or Protein)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Pneumocystis jiroveci (IVD Test Reagent/Kits, Serology, Fungi/Yeast)\tanhydrotetracycline oxygenase activity (Molecular Function)\tNuclear-Associated Protein SPAN-Xe (Regulatory Protein)\tGerson Diet (CAM Multimodality Therapy)", + "output": "IVD Test Reagent/Kits, Serology, Fungi/Yeast, Pneumocystis jiroveci (IVD Test Reagent/Kits, Serology, Fungi/Yeast)" + }, + { + "input": "Definition: Nucleic Acids described as double-stranded DNA or single-stranded RNA oligonucleotide sequences with the capacity to recognize target molecules with high affinity and specificity. Fundamentally distinct from antibodies, aptamers mimic their properties and have emerged as a promising class of molecules in both therapeutic and diagnostic formats. In having small size (8-15 kDa) relative to antibodies (150 kDa), aptamers are candidates for rapid tumor penetration and blood clearance.\nConcepts: aptamers (Nucleic Acid, Nucleoside, or Nucleotide)\tUnmethylated MGMT Glioblastoma (Glioblastoma)\tribostamycin degradation (antibiotic catabolic process)\tmannosyl diphosphorylinositol ceramide metabolism (Molecular Function)\tIndocyanine Green Solution (Indicator, Reagent, or Diagnostic Aid)", + "output": "aptamers (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Intellectual Product described as a question about how frequently an individual is or was more anxious about having prostate cancer whenever they heard about a friend or public figure with prostate cancer.\nConcepts: Antibody-Coated Plate (Research Device)\tDiphenhydramine/Phenylephrine-containing Syrup (Pharmacologic Substance)\tBPD, AE (Neonatal Adverse Event)\tCirculatory precautions (Precautionary procedure)\tMore Anxious about Having Prostate Cancer Whenever Hearing about Friend or Public Figure with Prostate Cancer (Clinical or Research Assessment Question)", + "output": "More Anxious about Having Prostate Cancer Whenever Hearing about Friend or Public Figure with Prostate Cancer (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in both the regulation of gene expression and tumor suppression.\nConcepts: KM12 (Experimental Model of Disease)\tp16INK4a Positive by Immunohistochemistry (Laboratory or Test Result)\tMICRO RNA 31 (MicroRNA Gene)\tpmol/L/(kg/m2) (Unit of concentration)\tforespore membrane SPB attachment site (cellular anatomical entity)", + "output": "MICRO RNA 31 (MicroRNA Gene)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of pro-platelet basic protein present in a sample.\nConcepts: pre-pulse inhibition (Thesaurus of Psychological Index Terms)\textended amygdala (Body Part, Organ, or Organ Component)\tPPBP (Laboratory Procedure)\tTorulopsis nadaensis (Fungus)\tRecognition odor (Biological Factors)", + "output": "PPBP (Laboratory Procedure)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Fungi/Yeast described as serology reagents intended to detect antigens to strains of species of the genus Blastomyces, imperfect fungi of the class Hyphomycetes. Some species of Blastomyces may cause self-limited or localized pulmonary lesions (blastomycosis); affected immunocompromised patients may develop a chronically progressive illness in the skin and/or organs (e.g., lungs, genitourinary tract, central nervous system).\nConcepts: Process output (Concept model attribute)\tRubella IgG Antibody Measurement (Rubella Antibody Measurement)\tSym015 (Amino Acid, Peptide, or Protein)\tcontrast-enhanced magnetic resonance imaging (Magnetic Resonance Imaging)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Blastomyces Species, Antigen (IVD Test Reagent/Kits, Serology, Fungi/Yeast)", + "output": "IVD Test Reagent/Kits, Serology, Fungi/Yeast, Blastomyces Species, Antigen (IVD Test Reagent/Kits, Serology, Fungi/Yeast)" + }, + { + "input": "Definition: Phosphatidylinositide 3-Kinase Inhibitor described as an orally bioavailable, highly selective small molecule inhibitor of the gamma isoform of phosphoinositide-3 kinase (PI3K-gamma) with potential immunomodulating and antineoplastic activities. Upon administration, IPI-549 prevents the activation of the PI3K-gamma-mediated signaling pathways, which may lead to a reduction in cellular proliferation in PI3K-gamma-expressing tumor cells. In addition, this agent is able to modulate anti-tumor immune responses and inhibit tumor-mediated immunosuppression. Unlike other isoforms of PI3K, the gamma isoform is overexpressed in certain tumor cell types and immune cells; its expression increases tumor cell proliferation and survival. By selectively targeting the gamma isoform, PI3K signaling in normal, non-neoplastic cells is minimally or not affected, which results in a reduced side effect profile.\nConcepts: Medullary Thyroid Carcinoma cNX TNM Finding v8 (Medullary Thyroid Carcinoma Clinical Regional Lymph Nodes TNM Finding v8)\taudiotape (Electronic recording medium)\tGrounded Theory (Intellectual Product)\tPI3K-gamma inhibitor IPI-549 (Pharmacologic Substance)\tunbound T4 level (Thyroxine measurement)", + "output": "PI3K-gamma inhibitor IPI-549 (Pharmacologic Substance)" + }, + { + "input": "Definition: Cell Function described as the series of events by which an injury stimulus is received and converted into a molecular signal.\nConcepts: GLUCOSYLCERAMIDASE (Gene or Genome)\tpericiliary membrane compartment (Region of plasma membrane)\tCOMPASS complex (Cell Component)\tTime management (Higher-level cognitive functions)\tdetection of injury (Cell Function)", + "output": "detection of injury (Cell Function)" + }, + { + "input": "Definition: Cell Component described as the outer of two mucus layers secreted by epithelial cells in the colon; the outer mucus layer is loosely packed and can be colonized by bacteria.\nConcepts: International Myositis Assessment and Clinical Studies Group (Professional Organization or Group)\tPledget (Biomedical or Dental Material)\tsuppression of transcription from RNA polymerase II promoter under ER stress (negative regulation of transcription from RNA polymerase II promoter in response to stress)\touter mucus layer (Cell Component)\tbranch elongation of an epithelium (Organism Function)", + "output": "outer mucus layer (Cell Component)" + }, + { + "input": "Definition: Potency Unit described as a United States liquid unit equal to 32 fluid ounces; four quarts equal one gallon.\nConcepts: neuropeptide receptor activity (Molecular Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SMN2 (Medical Device)\tCool Color Map (Color Mapping Function)\tRED-S (Mental or Behavioral Dysfunction)\tQUART (Unit of volume)", + "output": "QUART (Unit of volume)" + }, + { + "input": "Definition: Reproductive process described as any process that mediates the transfer of information from a mesenchymal cell to an epithelial cell where it is received and interpreted contributing to the progression of the prostate gland over time.\nConcepts: intersexuality (reproductive system disorder)\tmesenchymal-epithelial cell signalling involved in prostate gland development (Cell Function)\tBILIVERDIN IX-ALPHA REDUCTASE (Gene or Genome)\tMoldable Splints, Aluminum (Orthoses, Multipurpose Splint, Moldable)\tAdverse Event Location Description (Intellectual Product)", + "output": "mesenchymal-epithelial cell signalling involved in prostate gland development (Cell Function)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Functional Well-Being: I am able to enjoy life.\nConcepts: FAC017-I Am Able to Enjoy Life (FACT-LEU Version 4 Questionnaire Question)\tSclerosis of the middle phalanx of the 3rd toe (Sclerosis of middle toe phalanx)\tabl Gene (Proto-Oncogenes)\tPlannedExperimentalUnitAllocationResult (Finding)\tLymphoid Stem Cell (Hematopoietic stem cells)", + "output": "FAC017-I Am Able to Enjoy Life (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Neoplastic Process described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.\nConcepts: embolization uterine artery (Embolization of internal iliac artery)\tcellular protein complex disassembly (protein-containing complex disassembly)\tAngiocentric lymphoma stage IV (Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage)\tREG INSECT GROWTH (Insect Hormones)\tCOMPONENT, EXTERNAL, LIMB, ANKLE/FOOT (Medical Device)", + "output": "Angiocentric lymphoma stage IV (Nasal Type NK/T-Cell Lymphoma by Ann Arbor Stage)" + }, + { + "input": "Definition: something described as problem associated with installing updates to a software system that affects the device performance or communication with another device.\nConcepts: TNF Receptor Superfamily Member 19-Like (Amino Acid, Peptide, or Protein)\tPoorly cohesive carcinoma (Cystic, mucinous AND/OR serous neoplasm)\tCDC HIV High Risk Donor Indicator (Conceptual Entity)\tDietary Phospholipid (Dietary Fats)\tApplication Program Version or Upgrade Problem (Application Program Issue Associated with Medical Device)", + "output": "Application Program Version or Upgrade Problem (Application Program Issue Associated with Medical Device)" + }, + { + "input": "Definition: something described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 5, Word 6.\nConcepts: Reflux within Device Medical Device Problem (Improper Flow or Infusion)\tIDH Gene Family Mutation Status Unknown (Genetic finding)\tperineal fistula (Soft tissue lesion of pelvic region)\tAVL01074 (ADNI-AVLT Questionnaire Question)\tTubes, Esophageal, Decompression, Infant (Medical Device)", + "output": "AVL01074 (ADNI-AVLT Questionnaire Question)" + }, + { + "input": "Definition: Functional Concept described as injection of a medicinal product into the cardiac muscle and/or cardiac cavity.\nConcepts: FBXO32 (Gene or Genome)\tINTRACARDIAC (Cardiovascular route)\tTrkA-III (NTRK1 Gene Product)\tPsychrobacter phenylpyruvicus (Bovre and Henriksen 1967) Bowman et al. 1996 (Moraxella )\tHOSP NURSERY (Nurseries)", + "output": "INTRACARDIAC (Cardiovascular route)" + }, + { + "input": "Definition: something described as d(2) dopamine receptor (443 aa, ~51 kDa) is encoded by the human DRD2 gene. This protein plays a role in dopamine binding, angiogenesis inhibition, and receptor signaling.\nConcepts: SPWEIGHT (Mixed Category Laboratory Procedure)\tAsp (Dicarboxylate)\tGALK2 (phosphotransferase activity, alcohol group as acceptor)\tDRD2 (Dopamine Receptor)\tInfection, NOS (Infectious and Communicable Diseases)", + "output": "DRD2 (Dopamine Receptor)" + }, + { + "input": "Definition: Quantitative Concept described as the number of brothers that are biologically related to the subject.\nConcepts: Number of Brothers, Biological (Quantitative Concept)\ttyrosine biosynthetic process (alpha-amino acid biosynthetic process)\tAsparaginase-Doxorubicin-Prednisone-Vincristine (Regimen Used to Treat Acute Lymphoblastic Leukemia)\tAtrioventricular Nodal Reentrant Tachycardia (Finding)\tEMG: continuous motor unit activity at rest (Electromyogram abnormal)", + "output": "Number of Brothers, Biological (Quantitative Concept)" + }, + { + "input": "Definition: Homeopathic remedies letter R described as ribonucleic acid; polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached; RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity.\nConcepts: Abnormal dense granule content (Anatomical Abnormality)\tADCS-ADL Severe Dementia - Usual Conversation Participation (Intellectual Product)\trna (Homeopathic remedies letter R)\tMalignant Neoplasm of Lung - Multiple Primary Sites (Neoplastic Process)\tcellular response to triterpenoid (Cell Function)", + "output": "rna (Homeopathic remedies letter R)" + }, + { + "input": "Definition: Postgastrectomy Syndromes described as sequelae of gastrectomy from the second week after operation on. Include recurrent or anastomotic ulcer, postprandial syndromes (DUMPING SYNDROME and late postprandial hypoglycemia), disordered bowel action, and nutritional deficiencies.\nConcepts: Grade 3 Pain of Skin, CTCAE (Pain of Skin, CTCAE 5)\tQTCLSB (ECG Measurement)\tepithelial cell maturation involved in prostate gland development (Cell Function)\tPOST GASTRECTOMY SYNDROME (Functional digestive disorders, NEC in ICD9CM 2014)\tFAC10036 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "POST GASTRECTOMY SYNDROME (Functional digestive disorders, NEC in ICD9CM 2014)" + }, + { + "input": "Definition: something described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, urine) to identify and/or measure the levels of one or more of a group of chemical compounds administered to humans for diagnosis, treatment, or prevention of a disease or other abnormal condition or for the relief of pain (i.e., therapeutic drugs) present in the sample. These reagents are used in tests intended to monitor therapeutic drugs such as antibiotics, drugs for the cardiovascular and nervous systems, antiasthmatic drugs, antineoplastic drugs, immunosuppressants, and pain relievers.\nConcepts: Margins of excision (Post-surgical anatomy)\tPancreas neoplasm NOS (Neoplasm of intra-abdominal organs)\tSalivary duct inflammation (Gastrointestinal Disorders, CTCAE)\tImmunoassay Reagents, Therapeutic Drug (Medical Device)\tRetinal Cone Photoreceptor Cells (Neuron of retina)", + "output": "Immunoassay Reagents, Therapeutic Drug (Medical Device)" + }, + { + "input": "Definition: Anastomosis coupler described as implantable devices intended to be used to join and transect excess tissue of gastrointestinal structures, typically through the coupling of two ring-shaped components that are inserted into the ends of the segments to be attached. These devices may be permanent or biofragmentable.\nConcepts: EAR WASH, SOLUTION (Otic dosage form)\theteroglycan binding (Molecular Function)\tAcute myeloid leukaemia, CBF-beta/MYH11 (Neoplastic Process)\tHemoglobin-Beta Locus (Gene or Genome)\tDEVICE, ANASTOMOSIS FOR GASTRO-UROLOGY USE (Medical Device)", + "output": "DEVICE, ANASTOMOSIS FOR GASTRO-UROLOGY USE (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an orally bioavailable antagonist of the prostaglandin E2 receptor subtype 4 (PTGER4; EP4), with potential analgesic, immunomodulating and antineoplastic activities. Upon administration, the EP4 antagonist ONO-4578 selectively targets and binds to EP4, inhibiting the binding of the immunosuppressive prostaglandin E2 (PGE2) to EP4. This prevents the activation of EP4 and inhibits PGE2-EP4-mediated signaling, thereby inhibiting proliferation of tumor cells in which the PGE2-EP4 signaling pathway is over-activated. In addition, EP4 inhibition prevents the activity of tumor-associated myeloid cells (TAMCs) in the tumor microenvironment (TME) by inhibiting interleukin-23 (IL-23) production and the IL-23-mediated expansion of Th17 cells. EP4, a prostanoid receptor, is a G protein-coupled receptor that is expressed in certain types of cancers; it promotes tumor cell proliferation and invasion.\nConcepts: MF-3 (European Consensus on Grading of Bone Marrow Fibrosis)\tselective PGE2 receptor 4 antagonist ONO-4578 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tpositive regulation of T-cell migration (regulation of T cell migration)\t12l (area 12 of Carmichael)\textended-release onapristone (Progesterone Antagonist)", + "output": "selective PGE2 receptor 4 antagonist ONO-4578 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)" + }, + { + "input": "Definition: Receptor Tyrosine Kinase Gene described as this gene plays a regulatory role in angiogenesis.\nConcepts: Application (Functional Concept)\tDeep Intracranial Venous System (Intracranial Venous System)\tTIE1 (Gene or Genome)\tWas a TP53 Mutation Identified (Were Molecular Abnormalities Detected)\tgentian (Plant)", + "output": "TIE1 (Gene or Genome)" + }, + { + "input": "Definition: BIRC6 gene described as human BIRC6 wild-type allele is located within 2p22-p21 and is approximately 261 kb in length. This allele, which encodes baculoviral IAP repeat-containing protein 6, is involved in apoptotic inhibition by ubiquitination regulation.\nConcepts: CIC-DUX4 Sarcoma (Neoplastic Process)\tBaculoviral IAP Repeat-Containing Protein 6 Gene (Gene or Genome)\tPPD skin test (Delayed hypersensitivity skin test)\tRecommended nutrient intake (Nutritional Physiological Phenomena)\tHead Models, Human Anatomy (Manufactured Object)", + "output": "Baculoviral IAP Repeat-Containing Protein 6 Gene (Gene or Genome)" + }, + { + "input": "Definition: FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 (FACT-P Version 4) Physical Well-Being: I am forced to spend time in bed.\nConcepts: FACT-P Version 4 - I Am Forced to Spend Time in Bed (FACT-P Version 4 Questionnaire Question)\torap (Organic Chemical)\t1-4 finger syndactyly (Syndactyly of fingers)\tSuperficial Abdominal Muscle (Body Part, Organ, or Organ Component)\tcis-4-(8-hydroxypyren-7-yl)-2-oxobut-3-enoate lyase activity (oxo-acid-lyase activity)", + "output": "FACT-P Version 4 - I Am Forced to Spend Time in Bed (FACT-P Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs that selectively bind to and activate alpha adrenergic receptors.\nConcepts: Crushing pain (Pain by sensation quality)\tregulation of arachidonic acid secretion (Cell Function)\tDiabetes mellitus, NOS (Non-Cancer Diagnosis)\talpha adrenergic agent (Adrenergic Agents)\tLactams (nitrogenous heterocyclic compound)", + "output": "alpha adrenergic agent (Adrenergic Agents)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the gliadin IgG antibody in a biological specimen.\nConcepts: 3-propanolide (Cyclic Ether Carcinogen)\tGenus Pimenta (Plant)\tantibody Gliadin IgG (Immunoglobulin measurement)\tinvestigational (General Qualifier)\tUHDRS 1999 Version - Self-esteem/Guilt: Frequency (UHDRS 1999 Version Clinical Classification Question)", + "output": "antibody Gliadin IgG (Immunoglobulin measurement)" + }, + { + "input": "Definition: striated muscle cell proliferation described as the multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.\nConcepts: skeletal muscle cell proliferation (striated muscle cell proliferation)\tTime patient sent for (Temporal Concept)\tOLD ASSOCIATION (NCI Thesaurus Property)\tMNSI1-Hurt When Bed Covers Touch Skin (MNSI Questionnaire Question)\tKnowledge: cardiac disease management (Knowledge Level)", + "output": "skeletal muscle cell proliferation (striated muscle cell proliferation)" + }, + { + "input": "Definition: something described as human PSMB9 wild-type allele is located in the vicinity of 6p21.3 and is approximately 6 kb in length. This allele, which encodes proteasome subunit beta type-9 protein, plays a role in the regulation of the catabolism of proteins to generate class I major histocompatibility complex antigens.\nConcepts: UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity (Molecular Function)\tSloping ulnar metaphysis (Abnormality of ulnar metaphysis)\tManagement of soy protein intake (Health Care Activity)\tPSMB6i (PSMB9 gene)\tMelanoma of the Skin Clinical TNM Finding v8 (Finding)", + "output": "PSMB6i (PSMB9 gene)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with the tail region of a myosin II heavy chain.\nConcepts: Pvt1 oncogene homolog (Gene or Genome)\tPelczaria (Bacterium)\tmyosin II tail binding (myosin tail binding)\tantagonists agonists (Agent)\tDisconnected (Finding)", + "output": "myosin II tail binding (myosin tail binding)" + }, + { + "input": "Definition: Social Behavior described as rivalry between two or more individuals striving for the same goals; may also be used in relation to economics as an effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice.\nConcepts: platelet activating factor secretion (lipid localization)\tPQL11-Long Time to Bathe/Shower (Intellectual Product)\tNizp1 protein, human (Amino Acid, Peptide, or Protein)\tsocial competition (Social Behavior)\tIntegrin Beta 6 (Amino Acid, Peptide, or Protein)", + "output": "social competition (Social Behavior)" + }, + { + "input": "Definition: Publication Formats described as content from transmission of live or pre-recorded audio or video via connection or download from the INTERNET.\nConcepts: Lipoma of Parotid Gland (Neoplastic Process)\tWebcast (Intellectual Product)\tCardiopulmonary Stress Exercise Monitoring Systems (Stress exercise monitoring system)\tserine decarboxylase activity (Molecular Function)\tIntradermal melanocytic naevus (Nevus)", + "output": "Webcast (Intellectual Product)" + }, + { + "input": "Definition: Behavior described as sending and receiving verbal and nonverbal information\nConcepts: Acute pancreatitis (Classification)\tSpeckled calcifications in the end part of the outermost thumb bone (Stippling of thumb epiphysis)\tCommunication (Perception/cognition)\tSEER Geocode Region (Geographic Area)\tCDK2 Gene (Cyclin-Dependent Kinase Gene)", + "output": "Communication (Perception/cognition)" + }, + { + "input": "Definition: something described as somewhat flattened, globular echinoderms, having thin, brittle shells of calcareous plates. They are useful models for studying FERTILIZATION and EMBRYO DEVELOPMENT.\nConcepts: anger bhvr mgmt grp ea.h (Therapeutic or Preventive Procedure)\tUrchin, Sea (Eukaryote)\tPerformer Identifier (Intellectual Product)\tIn the last month, how often have you been able to control the way you spend your time (Intellectual Product)\taxoneme (Subcellular structure)", + "output": "Urchin, Sea (Eukaryote)" + }, + { + "input": "Definition: Family planning counseling described as a method of providing future reproductive opportunities before a medical treatment with known risk of loss of fertility. Typically reproductive organs or tissues (e.g., sperm, egg, embryos and ovarian or testicular tissues) are cryopreserved for future use before the medical treatment (e.g., chemotherapy, radiation) begins.\nConcepts: TESTER, PACEMAKER ELECTRODE FUNCTION (Medical Device)\tMI Positive (Laboratory or Test Result)\tFertility Care (Therapeutic procedure)\tCushing; syndrome or disease (Metabolic Diseases)\tODI01TN (CDISC Questionnaire Terminology)", + "output": "Fertility Care (Therapeutic procedure)" + }, + { + "input": "Definition: International Classification of Functioning, Disability and Health described as environmental factors considered as variables in disease incident, transmission, and control.\nConcepts: 48,XYYY syndrome (Disease or Syndrome)\tRadon (Radon and radon compound)\tmin*mol/L/(kg/m2) (Quantitative Concept)\tExogenous Factors (Epidemiological Factors)\tnicotania tabacum (Oils, Volatile)", + "output": "Exogenous Factors (Epidemiological Factors)" + }, + { + "input": "Definition: Molecular Sequence Data described as sequences of DNA or RNA that occur in multiple copies.\nConcepts: (11alpha,13E,15S)-11,15-dihydroxy-9-oxoprost-13-en-1-oic acid (Prostaglandin Analog [EPC])\tNUCLEIC ACID REPET SEQ (Nucleic Acid, Nucleoside, or Nucleotide)\tAnterior Annulus of the Mitral Valve (Structure of anulus fibrosus of mitral orifice)\tC-x(9)-C motif containing 2 (Gene or Genome)\t11-Dehydrothromboxane B2 Excretion Rate (Laboratory Procedure)", + "output": "NUCLEIC ACID REPET SEQ (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Laboratory Procedure described as sorting and/or purification of specific cells from a mixture using antibody-based reagents.\nConcepts: pT4 Exocrine Pancreatic Cancer v6 (Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v6)\tImmunological Flow Cytometry (Laboratory Procedure)\tTesticular Cancer cTis TNM Finding v8 (Testicular Cancer Clinical Primary Tumor TNM Finding v8)\tN-terminal protein myristoylation (Molecular Function)\tHendra-like virus (Henipavirus)", + "output": "Immunological Flow Cytometry (Laboratory Procedure)" + }, + { + "input": "Definition: Vitritis described as infection of the interior of the eye, especially the aqueous and/or vitreous humor, by a parasite.\nConcepts: Resiquimod (Pharmacologic Substance)\tNodi lymphoidei regionales (lymph nodes)\tpyridoxal metabolic process (organic hydroxy compound metabolic process)\tTumorigenicity Tests (Carcinogen Screening)\tendophthalmitis; parasitic (Other endophthalmitis)", + "output": "endophthalmitis; parasitic (Other endophthalmitis)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 5q\nConcepts: 5q33.2-qter (Cell Component)\tDental Materials, Restorative, Composite Resin, Heat-Cured (Medical Device)\tCSS01-Most Severe Ideation, Reasons (C-SSRS Baseline Questionnaire Question)\tOxidation of Odd-Numbered Chain Fatty Acid Pathway (Lipid Metabolism Pathway)\tResultor Moestrup, 1991, nom. inval. (Resultomonadaceae)", + "output": "5q33.2-qter (Cell Component)" + }, + { + "input": "Definition: something described as north Star Ambulatory Assessment (NSAA) Can you stand on your right leg for as long as you can?\nConcepts: NSAA1-Stand on One Leg - Right (NSAA Clinical Classification Question)\tStage I Liver Carcinoma (Neoplastic Process)\tmannoprotein metabolic process (Molecular Function)\tBland Embolization (Therapeutic or Preventive Procedure)\tFossa, Middle Cranial (Head and neck structure)", + "output": "NSAA1-Stand on One Leg - Right (NSAA Clinical Classification Question)" + }, + { + "input": "Definition: modification by symbiont of host cell membrane described as the aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction.\nConcepts: glycine transmembrane transporter activity (neutral amino acid transmembrane transporter activity)\tpore formation in membrane of other organism during symbiotic interaction (modification by symbiont of host cell membrane)\t1: 158288316-158302322 (Chromosome 1 Physical Location)\tPHYSIOLOGIC ANTAGONIST (Substance with receptor antagonist mechanism of action)\tLow Density Array (Hybridization Array)", + "output": "pore formation in membrane of other organism during symbiotic interaction (modification by symbiont of host cell membrane)" + }, + { + "input": "Definition: something described as a pathologist that submits a proposal or letter of intent to participate in a study or who submits results or diagnoses for use in a study.\nConcepts: CSS0103 (C-SSRS Baseline Questionnaire Question)\tMarchantia L., 1753 (Marchantiaceae)\tSubmitting Pathologist (Research Personnel)\tCrooke Hyaline Change (Finding)\tRefractory Ph-Like Acute Lymphoblastic Leukemia (Refractory Acute Lymphoblastic Leukemia)", + "output": "Submitting Pathologist (Research Personnel)" + }, + { + "input": "Definition: Quantitative Concept described as the number of regional nodes examined by the pathologist and found to contain metastases.\nConcepts: Number of Regional Lymph Nodes Positive (Quantitative Concept)\tTsukasaki Leukemia Lymphoma 2009 Oncology Response Criteria (Intellectual Product)\tSoftware, Physiologic Recording, Electroencephalography (Intellectual Product)\tNCI CTEP SDC Reproductive System Neoplasm, Female Category Terminology (Intellectual Product)\tWilms tumor 1 associated protein, human (Amino Acid, Peptide, or Protein)", + "output": "Number of Regional Lymph Nodes Positive (Quantitative Concept)" + }, + { + "input": "Definition: Cell Function described as maintaining a protein in an unfolded, soluble state.\nConcepts: IPAQ Short Last 7 Days Telephone Format Version - Days Moderate Physical Activities (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tablation cardiac (Cardiac therapeutic procedures)\tCardiotrophin 1 wt Allele (Gene or Genome)\tmaintenance of unfolded protein (regulation of protein stability)\tFDA Unique Device Identifier (Unique device identifier)", + "output": "maintenance of unfolded protein (regulation of protein stability)" + }, + { + "input": "Definition: something described as human PRRT2 wild-type allele is located in the vicinity of 16p11.2 and is approximately 4 kb in length. This allele, which encodes proline-rich transmembrane protein 2, may be involved in the development of the brain and spinal cord. Mutation of the gene is associated with both episodic kinesigenic dyskinesia-1 and infantile convulsion and choreoathetosis syndrome.\nConcepts: Childhood Intracortical Osteosarcoma (Childhood Osteosarcoma)\tTape (Medical Device)\tNucleoside Receptor Binding (Receptor Binding)\tPharmacogenomics/Genetics Methods and Supporting Information Test Name (Intellectual Product)\tDKFZp547J199 (Gene or Genome)", + "output": "DKFZp547J199 (Gene or Genome)" + }, + { + "input": "Definition: Professional or Occupational Group described as persons who assist ill, elderly, or disabled persons in the home, carrying out personal care and housekeeping tasks.\nConcepts: Focal autonomic seizure with lacrimation (Disease or Syndrome)\tMacrothrombocytopenia with mitral valve insufficiency (Thrombocytopenia)\tHome Health Aides (Occupational Groups)\tlimb regeneration (Natural regeneration)\tregulation of isomerase activity (Molecular Function)", + "output": "Home Health Aides (Occupational Groups)" + }, + { + "input": "Definition: Hemophagocytic Syndrome described as a rare disorder in which histiocytes and lymphocytes (types of white blood cells) build up in organs including the skin, spleen, and liver, and destroy other blood cells. Hemophagocytic lymphohistiocytosis may be inherited or caused by certain conditions or diseases, including infections, immunodeficiency (inability of the body to fight infections), and cancer.\nConcepts: neoplasm of adipose tissue (Lipomatous neoplasm)\tdorsal closure, amnioserosa morphology change (Organ or Tissue Function)\tlymphohistiocytosis; hemophagocytic (Certain diseases involving lymphoreticular tissue and reticulohistiocytic system)\tTEST,IMMUNOASSAY,BIOSENSOR,HCG (Medical Device)\tCough (Intellectual Product)", + "output": "lymphohistiocytosis; hemophagocytic (Certain diseases involving lymphoreticular tissue and reticulohistiocytic system)" + }, + { + "input": "Definition: Mental Process described as the awareness of the spatial properties of objects; includes physical space.\nConcepts: chlorophyllide a oxygenase activity (Molecular Function)\tGanglion, Sympathetic (Sympathetic nerve structure)\tnegative regulation of stem cell proliferation (Cell Function)\tjoy (Psychological Well Being)\tSpatial Orientation (Perception)", + "output": "Spatial Orientation (Perception)" + }, + { + "input": "Definition: something described as a drug hypersensitivity reaction with a relatively long latency period after exposure characterized by rash,fever, lymphadenopathy, hematologic abnormalities including eosinophilia and atypical lymphocytosis and internal organ involvement. Clinical presentation is highly variable. Eosinophilia is present in 50-90% of cases.\nConcepts: DRESS Syndromes (Allergic condition)\tSkilled Industrial Workers (Professional or Occupational Group)\tregulation of hormone metabolic process (Cell Function)\t3-hydroxypropionate:NADP+ oxidoreductase (Molecular Function)\tdouble-stranded DNA specific 5'-3' exodeoxyribonuclease activity (double-stranded DNA exodeoxyribonuclease activity)", + "output": "DRESS Syndromes (Allergic condition)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plastoglobule. Plastoglobule is a lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids.\nConcepts: positive regulation of embryonic skeletal joint development (Physiologic Function)\tplastoglobule organisation (Cell Function)\tSpent most of the day lifting or carrying heavy objects (Finding)\tBrachydactyly types B and E combined (Autosomal dominant hereditary disorder)\tInoculating Loops (Fixed Loop Instruments)", + "output": "plastoglobule organisation (Cell Function)" + }, + { + "input": "Definition: something described as a function that transforms the colors of one (source) image to the colors of another (target) image.\nConcepts: Aplasia of the pituitary gland (Finding)\tColor Map (Intellectual Product)\tsuccinate dehydrogenase complex location (succinate dehydrogenase complex location)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DHCR7 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tup-regulation of physiological fear response (Physiologic Function)", + "output": "Color Map (Intellectual Product)" + }, + { + "input": "Definition: something described as catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O.\nConcepts: Cancer Disease Progression (Tumor Progression)\tL-tryptophan,NADPH:oxygen oxidoreductase (Molecular Function)\tETH (Africa, Eastern)\tLevel of Joint Stiffness (Intellectual Product)\tType 1 Angiotensin Receptor Antagonists (Angiotensin Receptor Antagonists)", + "output": "L-tryptophan,NADPH:oxygen oxidoreductase (Molecular Function)" + }, + { + "input": "Definition: Raised hematology finding described as a laboratory test result which indicates increased levels of hemoglobin in a biological specimen.\nConcepts: phosphatidylinositol acyl-chain remodeling (phosphatidylinositol metabolic process)\tpteridine analog (Analog)\tcellular response to phenylpropanoid (cellular response to organic cyclic compound)\tregulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction (regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction)\themoglobin high (Red blood cell test)", + "output": "hemoglobin high (Red blood cell test)" + }, + { + "input": "Definition: Lesion of mucosa described as cervical glandular intraepithelial neoplasia characterized by the presence of mild dysplastic changes.\nConcepts: Low grade cervical glandular intraepithelial neoplasia (Lesion of mucosa)\tEnteric bacteria (Bacterium)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT2 TNM Finding v8 (Finding)\tEnvironmental pollution (Physical environment)\t8-demethylnovobiocate synthase activity (acid-ammonia (or amide) ligase activity)", + "output": "Low grade cervical glandular intraepithelial neoplasia (Lesion of mucosa)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the smallest of four parts of the cingulate cortex in the human and the macaque. The others are the anterior cingulate cortex, the midcingulate cortex, and the posterior cingulate cortex. It is a cytoarchitecturally defined portion of periarchicortex ( Stephan-1975 ).\\r\\nLocated in the ventral bank of the posterior cingulate gyrus and bordered internally by the callosal sulcus, it arches around the splenium of the corpus callosum. Externally it is bounded by area 23. It is continuous rostrally with area 33, which, similarly, separates an outer area 24 from the corpus callosum. It has two components: a granular area: area 29 ( Vogt-2012 ), and area 30, which is described as dysgranular by some authors ( Vogt-2012 ) and agranular by others ( Zilles-2004 ). \\r\\nIn the cerebrocortical segmentation of the fMRI-based Human Connectome Project ( Glasser-2016 ), it is named 'retrosplenial complex' and defined on the basis of internal MRI structure, connectivity, and fMRI activation during behavioral tasks. In that segmentation it is bounded, in caudorostral order, by area POS1, area v23ab, area d23ab, and area 23d. It has strong functional connectivity with area POS2. It is fMRI-activated in a MOTOR CUE task, activated or deactivated in WORKING MEMORY and GAMBLING tasks depending on the area compared, and deactivated in LANGUAGE STORY, STORY and THEORY OF MIND tasks ( Glasser-2016 ).\\r\\nIn the rat and mouse, area 29 is divided into two parts: retrosplenial dysgranular area and retrosplenial granular area ( Paxinos-2009b ).\nConcepts: sperm retrieval (Semen specimen collection)\tCortex, Retrosplenial (Cingulate Cortex)\tLeft aortic arch with retroesophageal right subclavian artery (Abnormal branching pattern of left aortic arch)\tHeat Shock Protein 90 Inhibitor DS-2248 (Pharmacologic Substance)\tCarts, Storage/Transport, Catheter (Carts, Storage/Transport)", + "output": "Cortex, Retrosplenial (Cingulate Cortex)" + }, + { + "input": "Definition: Neurobiology described as functions and activities of the nervous system as a whole or with reference to the peripheral or the central nervous system; includes the functioning of the nervous system in sensing changes in both the internal and external environments, the interpretation of those changes and the coordination of responses.\nConcepts: Genes, Protozoan (Gene or Genome)\tFocal aware emotional seizure with agitation (Focal aware emotional seizure)\tureteronephrectomy (Therapeutic or Preventive Procedure)\tAdenosine Triphosphatase, Myosin (Enzyme)\tneural function (Physiology)", + "output": "neural function (Physiology)" + }, + { + "input": "Definition: IL1RL1 gene described as human IL1RL1 wild-type allele is located in the vicinity of 2q12 and is approximately 41 kb in length. This allele, which encodes interleukin-1 receptor-like 1, is involved in immune response signal transduction.\nConcepts: regulation of sweet taste perception (regulation of sensory perception)\tLIVED IN REFUGEE CAMP (Organism Attribute)\tCardiac Dysrhythmia Gene Panel Reagents (Medical Device)\t1p22.1 (Chromosome band)\tIL1RL1 wt Allele (Gene or Genome)", + "output": "IL1RL1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized cell acquires specialized features of a neuron.\nConcepts: HIV-1 Load (Viral Load result)\tGrade 2 Administration Site Complication Neonatal (Neonatal Administration Site Complication, AE)\tventral horn of the spinal cord (Body Part, Organ, or Organ Component)\tneuron differentiation (Cell Function)\tCalreticulin Protein Variant (Gene Product Sequence Variation)", + "output": "neuron differentiation (Cell Function)" + }, + { + "input": "Definition: positive regulation of oxidoreductase activity described as any process that activates or increases the frequency, rate or extent of ribonucleoside-diphosphate reductase activity.\nConcepts: glucuronoside synthesis (carboxylic acid biosynthetic process)\tMOV34-34KD (Genes, Regulator)\tSheltered workshops (Rehabilitation)\tbundle of Probst (Body Part, Organ, or Organ Component)\tpositive regulation of ribonucleoside-diphosphate reductase activity (positive regulation of oxidoreductase activity)", + "output": "positive regulation of ribonucleoside-diphosphate reductase activity (positive regulation of oxidoreductase activity)" + }, + { + "input": "Definition: fungal-type cell wall disassembly described as any fungal-type cell wall disassembly that is involved in conjugation with cellular fusion.\nConcepts: anaerobic pectin degradation (pectin catabolic process)\tfungal-type cell wall disassembly involved in conjugation with cellular fusion (cell wall organization involved in conjugation with cellular fusion)\tTECHNOL HIGH COST (Occupation or Discipline)\thypotonic-hyporesponsive episode (BODY AS A WHOLE - GENERAL DISORDERS)\tKeratosis NOS (Hyperkeratosis)", + "output": "fungal-type cell wall disassembly involved in conjugation with cellular fusion (cell wall organization involved in conjugation with cellular fusion)" + }, + { + "input": "Definition: something described as any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Taenia saginata, DNA (Medical Device)\tRecurrent T-Cell Prolymphocytic Leukemia (Recurrent Lymphoproliferative Disorder)\tBronchial Balloon Hemostatic Catheters (Bronchial balloon catheter)\tRecurrent High Grade Fallopian Tube Serous Adenocarcinoma (High Grade Fallopian Tube Serous Adenocarcinoma)\tnegative regulation of cell communication (negative regulation of cellular process)", + "output": "negative regulation of cell communication (negative regulation of cellular process)" + }, + { + "input": "Definition: something described as the study of human populations to identify causes of disease and factors determining and influencing the frequency and distribution of disease, injury, and other health related events. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C15721\" active clinical trials using this agent.\nConcepts: Epidemiology Research (Epidemiologic Study Characteristics)\tSubcortical band heterotopia (Brain Development Abnormality)\tNucleolin wt Allele (Gene or Genome)\tDeferent duct fluid (Portion of body fluid suspension)\tVon Bogaert-Bertrand Disease (Hereditary Central Nervous System Demyelinating Diseases)", + "output": "Epidemiology Research (Epidemiologic Study Characteristics)" + }, + { + "input": "Definition: something described as a non-Hodgkin lymphoma occurring in HIV-positive patients. It is composed of small cleaved lymphocytes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8297\" active clinical trials using this agent.\nConcepts: 16q13 (Cell Component)\tKitasamycin (Leucomycins)\tDRRI-2 - H: Prepared to Operate as Team (DRRI-2 Questionnaire Question)\tAIDS-associated diffuse small cleaved cell lymphoma (Neoplastic Process)\tRisk for decreased cardiac tissue perfusion (Cardiovascular/pulmonary responses)", + "output": "AIDS-associated diffuse small cleaved cell lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure.\nConcepts: ul/{dose} (Unit of Dose Calculation)\telectron transfer activity (oxidoreductase activity)\tProlonged-release oral granules (Biomedical or Dental Material)\tContrast Enhanced Digital Mammography (Digital Mammography)\temboliform nucleus development (Organ or Tissue Function)", + "output": "emboliform nucleus development (Organ or Tissue Function)" + }, + { + "input": "Definition: Temporal Concept described as the date and time of tumor findings data collection.\nConcepts: Rumination (Feeding and Eating Disorders)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, AFG3L2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tLatex allergy response risk (Finding)\tTumor Findings Collection Date Time (Collection Date Time)\tVM4-037 (Radioconjugate)", + "output": "Tumor Findings Collection Date Time (Collection Date Time)" + }, + { + "input": "Definition: something described as RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits.\nConcepts: ATP2B (Amino Acid, Peptide, or Protein)\tAbnormal Serum Immunoglobulin Free Light Chain Ratio (Abnormal Blood Chemistry and Hematology Test Result)\tMegakaryocyte to Total Cell Ratio Measurement (Laboratory Procedure)\tHow True Feel Sluggish Right Now (Intellectual Product)\tRNA polymerase V complex (Cell Component)", + "output": "RNA polymerase V complex (Cell Component)" + }, + { + "input": "Definition: something described as a non-metastasizing neoplasm arising from the fibrous tissue. It is characterized by the presence of spindle-shaped fibroblasts.\nConcepts: Fibroma, no International Classification of Diseases for Oncology subtype (Sarcoma of soft tissue)\t5-dehydro-2-deoxy-D-gluconate-6-phosphate malonate-semialdehyde-lyase activity (Molecular Function)\tBH4 Domain (Bcl-2 Homology Domain)\tCLP1, cleavage and polyadenylation factor I subunit, homolog (Gene or Genome)\tpresynaptic modulation of chemical synaptic transmission (modulation of chemical synaptic transmission)", + "output": "Fibroma, no International Classification of Diseases for Oncology subtype (Sarcoma of soft tissue)" + }, + { + "input": "Definition: Medical Device described as wooden sticks intended for medical and/or cosmetic uses. These devices are thin, flat sticks made of fine-grain wood (originally orange wood), providing a smooth finish and good tensile strength. Orange sticks may be used to apply ointments on the skin, for manicuring fingernails, or to depress the tongue during oral examination; they are also used in some biting tests that help determine proper mandible function (e.g., to assess possible mandible fracture).\nConcepts: up regulation of epithelial to mesenchymal transition involved in endocardial cushion formation (regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)\tOrange Sticks (Device Labeled for Single Use)\tEpidermal naevus (Non-neoplastic nevus of skin)\tSPSMTIME (Elapsed Time)\tregulation of ascospore formation (regulation of sexual sporulation resulting in formation of a cellular spore)", + "output": "Orange Sticks (Device Labeled for Single Use)" + }, + { + "input": "Definition: Lesion described as the largest tumor lesion targeted by therapy.\nConcepts: Trankimazin (Organic Chemical)\tNeonatal Alloimmune Thrombocytopenias (Neonatal disorder)\tIndex Lesion (Lesion)\tCTP:2-trans,-6-trans-farnesol phosphotransferase activity (farnesol kinase activity)\tFoetal parvovirus syndrome (Infections, Parvovirus)", + "output": "Index Lesion (Lesion)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of apolipoprotein C2 present in a sample.\nConcepts: Apolipoprotein C2 (Laboratory Procedure)\tClinical Stage IVB Gastroesophageal Junction Adenocarcinoma AJCC v8 (Neoplastic Process)\tAurum muriaticum natronatum / double chloride of gold and sodium / sodium chloroaurate (Inorganic Chemical)\tRHBDF2 Gene (Gene or Genome)\tbutyrate metabolism (Molecular Function)", + "output": "Apolipoprotein C2 (Laboratory Procedure)" + }, + { + "input": "Definition: Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Primary Tumor TNM Finding v8 described as regional skin involvement: multiple lesions limited to one body region or two contiguous body regions.\nConcepts: negative regulation of steroid hormone biosynthetic process (Molecular Function)\tPrimary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma T2 TNM Finding v8 (Finding)\tresponse to propan-1-ol (Cell Function)\tWD2-Concentrating for Ten Minutes (Intellectual Product)\tCoronary Thrombus TIMI Grade Clinical Classification Test Name (CDISC Clinical Classification Terminology)", + "output": "Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma T2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as a type of allergic process that results in an immune response to a foreign antigen.\nConcepts: down regulation of SUMO conjugating enzyme activity (negative regulation of transferase activity)\tAllergic sensitization process (Sensitization process)\tINTERVENING SEQ (Genes)\tKennedy's Disease (Spinal Muscular Atrophy)\tGlcNAc transferase activity (hexosyltransferase activity)", + "output": "Allergic sensitization process (Sensitization process)" + }, + { + "input": "Definition: ether metabolic process described as the chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.\nConcepts: childhood subependymal giant cell astrocytoma (Neoplastic Process)\tepoxide metabolic process (Molecular Function)\tacnu (Pharmacologic Substance)\tMAPKKK3 (Gene or Genome)\tchemotherapeutics growth-signaling inhibitors lorlatinib (Antineoplastic Enzyme Inhibitor)", + "output": "epoxide metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 755 of the coding sequence of the FGFR2 gene where cytosine has been mutated to guanine.\nConcepts: NM 000141.4:c.755C>G (FGFR2 Gene Mutation)\tInherited Maternally (Genetic Function)\tresponse to nitrosative stress (biological adaptation to stress)\tLaw, Natural (Idea or Concept)\tbotulinum toxin (Allergen class)", + "output": "NM 000141.4:c.755C>G (FGFR2 Gene Mutation)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the mediation of leukocyte rolling and cell adhesion.\nConcepts: negative regulation of mesonephric glomerulus development (negative regulation of mesonephros development)\tENDINSPR (Finding)\tBocaviruses (Virus)\tUDP-rhamnose metabolism (nucleotide-sugar metabolic process)\tSELPLG (Cell Adhesion Molecule Gene)", + "output": "SELPLG (Cell Adhesion Molecule Gene)" + }, + { + "input": "Definition: Cell Function described as megakaryocyte Proliferation involves multiplication or reproduction through cell division of megakaryocytes, a large cell in the bone marrow with a lobulated nucleus that releases mature blood platelets from its cytoplasm.\nConcepts: Megakaryocyte Proliferation (Cell Function)\tregulation of early endosome to late endosome transport (regulation of vesicle-mediated transport)\tPSA Level Greater than One Hundred and Fifty (Laboratory or Test Result)\tT-Box Brain2 (Amino Acid, Peptide, or Protein)\tmL/cage/wk (Quantitative Concept)", + "output": "Megakaryocyte Proliferation (Cell Function)" + }, + { + "input": "Definition: Quantitative Concept described as a recognized billing qualifier that may be used to identify a milliliter as the NDC unit of measure. This is often used when describing a liquid, solution, or suspension.\nConcepts: 4-AD 9alpha-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)\tNational Drug Code Milliliter (National Drug Code Unit of Measure)\tWhen drinking beer, wine or other spirits (Intellectual Product)\tADL03-Pastime: Other (Intellectual Product)\tLung Cancer cM1 TNM Finding v7 (Finding)", + "output": "National Drug Code Milliliter (National Drug Code Unit of Measure)" + }, + { + "input": "Definition: Intellectual Product described as modified Fatigue Impact Scale (MFIS) Because of my fatigue during the past 4 weeks I have been less motivated to do anything that requires physical effort.\nConcepts: behavioral therapy (Learning)\tMFIS - Less Motivated to Do Anything That Requires Physical Effort (MFIS Questionnaire Question)\tCardenolide (cardiac glycoside aglycone)\tHas died (General clinical state finding)\tUDP-xylose transmembrane transporter activity (pyrimidine nucleotide-sugar transmembrane transporter activity)", + "output": "MFIS - Less Motivated to Do Anything That Requires Physical Effort (MFIS Questionnaire Question)" + }, + { + "input": "Definition: Laparoscopic Procedures on the Biliary Tract described as surgical removal of the gallbladder,using a laparoscope.\nConcepts: diiodophenylpyruvate reductase activity (Molecular Function)\tFenretinide Lipid Matrix (Organic Chemical)\tlap chole (Cholecystectomy procedure)\tSEND Microbiology Test Code (CDISC SEND Terminology)\tregulation of protein folding in endoplasmic reticulum (Cell Function)", + "output": "lap chole (Cholecystectomy procedure)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions or duplications of the aprataxin (APTX) gene, located at chromosome 9p13.3, which encodes the protein aprataxin. Genetic variants at this locus have been associated with adult onset ataxia with oculomotor apraxia.\nConcepts: Lab Supply Import Documentation (Document type)\tplasma membrane raft (Region of plasma membrane)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, APTX (Medical Device)\tCLSIG (Finding)\tepiboly (morphogenesis of an epithelial sheet)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, APTX (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) Are you responsible for any household duties/housework/homemaker activities (e.g., cleaning, shopping, doing dishes, food shopping or preparation) for your-self or for other people?\nConcepts: NCI CTEP SDC Hematopoietic Neoplasm (excluding Leukemia, Lymphoma and Myeloma) Category Terminology (Intellectual Product)\tQ-LES-Q - Responsible for Household (Intellectual Product)\tunrelated (General Qualifier)\tpoloxalene (Surface-Active Agents)\tC130133 (Immunoglobulin measurement)", + "output": "Q-LES-Q - Responsible for Household (Intellectual Product)" + }, + { + "input": "Definition: Human described as a person or entity with a role in a clinical study. NOTE: Participants can be human subjects or study personnel. The term \"participant\" is used with growing frequency in some clinical and patient-facing documents like the informed consent form, Plain Language Summaries of study results, and publications. Subject or patient are terms used in regulatory guidelines, databases, other clinical research documents, or systems to refer to study participants. See also human subject, patient, study participant.\nConcepts: Entity With Role in Clinical Study (Human)\tUDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity (UDP-galactosyltransferase activity)\tent-copalyl-diphosphate diphosphate-lyase (Molecular Function)\tpositive regulation of amine metabolism (regulation of cellular amine metabolic process)\tfilix mas/male fern (Homeopathic remedies letter F)", + "output": "Entity With Role in Clinical Study (Human)" + }, + { + "input": "Definition: Test Result described as the result of the investigation of the absorption, distribution, metabolism, and excretion (ADME) of an experimental substance by an organism.\nConcepts: Medullary Thyroid Carcinoma Clinical Regional Lymph Nodes TNM Finding v8 (Medullary Thyroid Carcinoma Clinical TNM Finding v8)\tQS-PROSQOLI TEST (Intellectual Product)\tmethyl alcohol (Organic Chemical)\tAbsorption, Distribution, Metabolism, and Excretion Finding (Finding)\tfood processing/preparation (Food Science and Technology)", + "output": "Absorption, Distribution, Metabolism, and Excretion Finding (Finding)" + }, + { + "input": "Definition: MYELODYSPLASTIC SYNDROME described as a rare disorder caused by loss of part of the long arm (Q arm) of human chromosome 5. This syndrome affects myeloid (bone marrow) cells, causing treatment-resistant anemia, and myelodysplastic syndromes that may lead to acute myelogenous leukemia.\nConcepts: COGNITIVE DISTURBANCE (Neurological observations)\tMyelodysplastic syndrome with 5Q deletion (Primary malignant neoplasm of bone marrow)\tanaerobic rhamnose catabolic process (Molecular Function)\tMonoterpenes, Cyclopentane (Organic Chemical)\tTRKA (Gene or Genome)", + "output": "Myelodysplastic syndrome with 5Q deletion (Primary malignant neoplasm of bone marrow)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 7p\nConcepts: BNT-411 (Immunologic Factor)\t*Arbitrary (Qualitative Concept)\tconn's syndrome (Hyperaldosteronism)\tFamilial Sarcoma Gene Panel Reagents (Medical Device)\t7p15-p13 (Chromosome band)", + "output": "7p15-p13 (Chromosome band)" + }, + { + "input": "Definition: Kluyveromyces described as a species of yeasts in the family Saccharomycetaceae and phylum Ascomycota with the ability to utilize lactose and convert it into lactic acid. The species is heterothallic, with a predominantly haploid life cycle. K. lactis has emerged as an important yeast species for research and industrial biotechnology.\nConcepts: COX6C wt Allele (COX6C gene)\tRoleClassServiceDeliveryLocation (event location)\tCandida sphaerica (Fungus)\tMVP Gene (Gene or Genome)\tneurotransmitter binding (Molecular Function)", + "output": "Candida sphaerica (Fungus)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals.\nConcepts: positive regulation of fructose 1,6-bisphosphate metabolic process (positive regulation of phosphate metabolic process)\tangiostatin binding (Protein Binding)\tHypoxia (Oxygen Disorders)\tammonium transmembrane transporter activity (monovalent inorganic cation transmembrane transporter activity)\tMyelocyte Count (White Blood Cell Count procedure)", + "output": "ammonium transmembrane transporter activity (monovalent inorganic cation transmembrane transporter activity)" + }, + { + "input": "Definition: Thoracic aorta described as an artery arising from the thoracic aorta that runs along the bottom of the twelfth rib.\nConcepts: CXC Chemokine Receptor 6 (Amino Acid, Peptide, or Protein)\tArthrogryposis, distal (Congenital contracture)\tUse Trials, Compassionate (Therapies, Investigational)\tPreexisting Chronic Kidney Disease, Stage 3 (Finding)\tStructure of subcostal artery (Posterior chest wall)", + "output": "Structure of subcostal artery (Posterior chest wall)" + }, + { + "input": "Definition: Published Comment described as additional description of the reference result. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: X: 128382976-128306013 (Spatial Concept)\tR-SPONDIN 3 (Gene or Genome)\tReference Result Comment (Intellectual Product)\tBlocks, Residual (Pathologic Function)\tPR55alpha (PPP2R2A gene)", + "output": "Reference Result Comment (Intellectual Product)" + }, + { + "input": "Definition: something described as a burn caused by exposure to x-ray, radium, sunlight, atomic or any other type of radiant energy.\nConcepts: Satisfaction with How Your Abdomen Looks When Unclothed (Clinical or Research Assessment Question)\thistone methylase activity (Molecular Function)\tRibonuclease Inhibitor (Enzyme inhibitor protein)\tMetamyelocyte to Leukocyte Ratio Measurement (Laboratory Procedure)\tRadiation Burn (Injury or Poisoning)", + "output": "Radiation Burn (Injury or Poisoning)" + }, + { + "input": "Definition: Bacillus cereus group described as a species of aerobic or facultatively anaerobic, Gram-positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is motile, spore forming, and catalase positive, hydrolyzes casein, starch, and gelatin, and produces the toxin cereulide. B. cereus is found in soil and associated with diarrheal and emetic forms of food-borne illness as well as opportunistic infections in both humans and domestic animals.\nConcepts: Centrifuges, Tabletop, High-Speed (Medical Device)\tBacillus endorhythmos (Bacterium)\tMDS-UPDRS Questionnaire Question (Intellectual Product)\tHMN2 (HSPB8 gene)\tXylylcarb (Acetylcholinesterase Inhibitors)", + "output": "Bacillus endorhythmos (Bacterium)" + }, + { + "input": "Definition: Virus described as RNA viruses that have their genetic material encoded in the form of single-stranded, positive-sense RNA. Unlike RETROVIRUSES they do not employ DNA intermediates in their life-cycle.\nConcepts: Renal Pelvis and Ureter Cancer Clinical TNM Finding v8 (Renal Pelvis and Ureter Cancer TNM Finding v8)\t3-hydroxy-arachidoyl-CoA dehydratase activity (hydro-lyase activity)\tRNA Virus, Positive-Strand (Virus)\tAnti-GITR Monoclonal Antibody MK-4166 (Antineoplastic Antibody)\tperoxisomal transport (Cell Function)", + "output": "RNA Virus, Positive-Strand (Virus)" + }, + { + "input": "Definition: Fibroid Tumor described as a benign smooth muscle neoplasm arising from the small intestine. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.\nConcepts: Autoradiograph (Plain x-ray)\tSmall intestinal leiomyoma (Uterine Fibroids)\tResident physician (Medical practitioner grade)\tNPI - Show Any Other Signs of Feeling Too Good or Being Too Happy (NPI Questionnaire Question)\tDiaphanography (Miscellaneous diagnostic tests)", + "output": "Small intestinal leiomyoma (Uterine Fibroids)" + }, + { + "input": "Definition: methanogenesis described as the chemical reactions and pathways resulting in the formation of a methane from a formic acid.\nConcepts: Hypercitraturia (Finding)\tmethane biosynthetic process from formic acid (Molecular Function)\tSeizure;atonic (Seizures and seizure disorders NEC)\tFamily integration promotion group each 60 minutes (Therapeutic or Preventive Procedure)\tSleep-wake cycle disturbance (Finding)", + "output": "methane biosynthetic process from formic acid (Molecular Function)" + }, + { + "input": "Definition: Body tissue described as tissue and cells derived from nonhuman animals for use in research, as opposed to whole living animals.\nConcepts: BCLX protein, human (BCL2L1 Gene Product)\tMerkel Cell Carcinoma Pathologic TNM Finding v8 (Finding)\tThreonine to Creatinine Ratio Measurement (Laboratory Procedure)\tanimal tissues (Tissue)\tSomatotropin abnormal (Finding)", + "output": "animal tissues (Tissue)" + }, + { + "input": "Definition: something described as a biphasic synovial sarcoma arising from the lungs.\nConcepts: Food--Packaging (Food Handling)\tSyndecan 4 Gene (Cell Adhesion Molecule Gene)\tSignal (Conceptual Entity)\t46,XY disorder of sex development, adrenal insufficiency due to cytochrome P450 family 11 subfamily A member 1 deficiency (Reproductive system hereditary disorder)\tLung Biphasic Synovial Sarcoma (Synovial sarcoma, biphasic)", + "output": "Lung Biphasic Synovial Sarcoma (Synovial sarcoma, biphasic)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of activation-induced cell death of T cells.\nConcepts: Synthesis, Ribosomal Protein (Genetic finding)\ttemporal artery biopsy (Procedure on artery of head and neck)\tOral Health and Dental History Questions (Intellectual Product)\tCornus nuttallii / Pacific dogwood (Pharmacologic Substance)\tpositive regulation of activation-induced cell death of T cells (positive regulation of immune system process)", + "output": "positive regulation of activation-induced cell death of T cells (positive regulation of immune system process)" + }, + { + "input": "Definition: something described as transferring neural cells, tissues or organs within an individual, between individuals of the same species, or between individuals of different species.\nConcepts: PF04518600 (Anti-OX40 Monoclonal Antibody)\tnervous system transplantation (Neurosurgical Procedures)\tAJCC V7 (Clinical Classification)\tl/pg/min (Quantitative Concept)\tANNULLED (Finding)", + "output": "nervous system transplantation (Neurosurgical Procedures)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Measles (Rubeola) virus IgM antibody in a biological specimen.\nConcepts: negative regulation of neutrophil mediated killing of bacterium (Cell Function)\tHave Mood Swings (Intellectual Product)\tpreclinical studies (Study)\tMetacarpal bone, NOS (Skeletal bone)\tRubeola IgM Antibody Measurement (Measles antibody Assay)", + "output": "Rubeola IgM Antibody Measurement (Measles antibody Assay)" + }, + { + "input": "Definition: pre-miRNA described as MIR206 is an oligoribonucleotide that is encoded by the human MIR206 gene and has a role in the regulation of gene expression.\nConcepts: NCI CTEP SDC Embryonal Tumors of the CNS Sub-Category Terminology (NCI CTEP SDC CNS Neoplasm (Primary Tumor) Category Terminology)\tEGFR-targeted EnGeneIC dream vectors containing doxorubicin (EGFR-targeting Agent)\tHemofiltration solution (Dialysis dosage form)\tMIR206 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\thydronephrosis (Kidney)", + "output": "MIR206 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as columbia-Suicide Severity Rating Scale Since Last Visit test code.\nConcepts: Reese-Ellsworth Classification IA (Reese-Ellsworth Classification Group I)\tBiologicEntityPart.anatomicSiteLateralityCode (Intellectual Product)\tCSS02TC (Intellectual Product)\tCytochrome c6 (Cytochrome c Group)\tParvorder (Classification)", + "output": "CSS02TC (Intellectual Product)" + }, + { + "input": "Definition: Carpometacarpal joint structure described as a plane joint between the fifth metacarpal and the pisiform.\nConcepts: CGI Original Version - Efficacy Index (Intellectual Product)\tCarpometacarpal Joint 5 (Carpometacarpal joint structure)\tup regulation of mammary gland epithelial cell proliferation (positive regulation of developmental process)\tAntioxidant Activity (molecular function)\tMarketed under Conditional NADA (Structured Product Labeling Marketing Category)", + "output": "Carpometacarpal Joint 5 (Carpometacarpal joint structure)" + }, + { + "input": "Definition: Breast Carcinoma described as breast Carcinoma that is negative for hormone receptors.\nConcepts: Estrogen Receptor and Progesterone Receptor Negative Breast Carcinoma (Neoplastic Process)\tGTF3C4 Gene (Gene or Genome)\tNKG2D Ligand 1 (Amino Acid, Peptide, or Protein)\tADAMS-STOKES SYNDROME (Disease or Syndrome)\tDecreased mean platelet volume (Abnormal platelet volume)", + "output": "Estrogen Receptor and Progesterone Receptor Negative Breast Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: sulfur compound binding described as interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system.\nConcepts: alpha-amino acid anabolism (Molecular Function)\tpenicillin binding (organic cyclic compound binding)\tUnknown Primary Tumor cN2b TNM Finding v8 (Finding)\tPhenytoin level (Measurement of substance)\tSynapsis (Intercellular Junctions)", + "output": "penicillin binding (organic cyclic compound binding)" + }, + { + "input": "Definition: Intellectual Product described as test codes of questionnaire questions associated with the Expanded Prostate Cancer Index Composite Short Form (EPIC-26) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Purchasing, Shared (Purchasing, Hospital)\tserine decarboxylase activity (Molecular Function)\tinterstitial collagenase (Gene or Genome)\tANTISERUM, CF, LYMPHOCYTIC CHORIOMENINGITIS VIRUS (Indicator, Reagent, or Diagnostic Aid)\tEPIC1TC (Intellectual Product)", + "output": "EPIC1TC (Intellectual Product)" + }, + { + "input": "Definition: something described as a process of DNA-dependent DNA replication initiation that occurs as part of premeiotic DNA replication.\nConcepts: AlphaX Integrin Chain Negative (Expression Negative)\tDEXTROSE (glucose)\tarchives (History)\tanesthesiology (Specialties, Surgical)\tpremeiotic DNA replication initiation (Genetic Function)", + "output": "premeiotic DNA replication initiation (Genetic Function)" + }, + { + "input": "Definition: something described as cell-cell signaling between presynapse and postsynapse mediated by a soluble gas ligand crossing the synaptic cleft.\nConcepts: trans-synaptic signaling by soluble gas (trans-synaptic signaling)\tinterim clinical trial/study report (Intellectual Product)\tGrade 3 Infant Sedation (Infant Sedation, Adverse Event)\tchildhood CML (Neoplastic Process)\tMetatarsophalangeal Joint 1 (Metatarsophalangeal joint structure)", + "output": "trans-synaptic signaling by soluble gas (trans-synaptic signaling)" + }, + { + "input": "Definition: something described as a cardiopulmonary bypass level sensing monitor and/or control is a device used to monitor and/or control the level of blood in the blood reservoir and to sound an alarm when the level falls below a predetermined value.\nConcepts: U.V. METHOD, GALACTOSE (Medical Device)\tclear cell sarcoma of the kidney (Sarcoma of kidney)\tAbdomen injury NOS (Injury or Poisoning)\tGAIA Neonatal Encephalopathy Level of Diagnostic Certainty Terminology (GAIA Terminology)\tMONITOR AND/OR CONTROL, LEVEL SENSING, CARDIOPULMONARY BYPASS (Medical Device)", + "output": "MONITOR AND/OR CONTROL, LEVEL SENSING, CARDIOPULMONARY BYPASS (Medical Device)" + }, + { + "input": "Definition: Complicated hereditary spastic paraplegia described as syndrome with the association of an axonal sensory and autonomic neuropathy and spastic paraplegia. So far, around nine families have been described in the literature, together with a few sporadic cases. Onset occurs between 1 and 5 years of age with spasticity and progressive severe loss of temperature and pain sensation associated with ulcero-mutilating acropathy. Linkage to chromosome 5q15.31-14.1 was identified in a consanguineous Moroccan family with an autosomal recessive mode of inheritance. Early reports suggested autosomal dominant inheritance but transmission in more recently described families appeared to be autosomal recessive.\nConcepts: Alabama Parenting Questionnaire (Research or Clinical Assessment Tool)\tHereditary sensory and autonomic neuropathy with spastic paraplegia (Disease or Syndrome)\tregulation of mitochondrial RNA catabolic process (regulation of RNA metabolic process)\tRecurrent Acute Myeloid Leukemia with Recurrent Genetic Abnormalities (Recurrent Acute Myeloid Leukemia)\tProduct Testing Laboratory - Independent (Health Care Related Organization)", + "output": "Hereditary sensory and autonomic neuropathy with spastic paraplegia (Disease or Syndrome)" + }, + { + "input": "Definition: Medical Device described as analytical instruments designed to identify and quantify elements and compounds by sorting of gaseous ions in electric and/or electromagnetic fields to determine their mass-to-charge ratio using electrical detection.. These devices typically consist of a sample inlet, a high vacuum system, an ionization chamber with an ion source to produce a beam of charged particles, a mass analyzer to separate the beam in its components, an electrical detector, and computerized data system. Samples can be inserted directly into the sample inlet or injected into a gas or liquid chromatograph previously to separate the sample into individual components. Mass spectrometers are frequently classified according to the type of mass analyzer used (e.g., magnetic sector, double focusing, ion trap). They are used in the clinical laboratory and also in monitors dedicated to measure inspired and/or exhaled gas concentrations (e.g., oxygen, nitrogen, halogenated anesthetics) during surgical procedures.\nConcepts: Spectrometers, Mass (Medical Device)\tHDCAB1-HD-CAB Total Score (Intellectual Product)\tSnares, Eye, Enucleation (Snare instrument)\tPontocerebellar fibers (Body Part, Organ, or Organ Component)\tCholedochocoele (Cyst of biliary tract)", + "output": "Spectrometers, Mass (Medical Device)" + }, + { + "input": "Definition: Epstein-Barr Virus Infections described as infection with human herpesvirus 4 (HERPESVIRUS 4, HUMAN); which may facilitate the development of various lymphoproliferative disorders. These include BURKITT LYMPHOMA (African type), INFECTIOUS MONONUCLEOSIS, and oral hairy leukoplakia (LEUKOPLAKIA, HAIRY).\nConcepts: eyelid disorder edema (Other disorders of eyelid)\tinfection epstein-barr virus (Virus Diseases)\tMRXS21 (Intellectual Disability)\tFACT-LYM Version 4 - I Get Tired Easily (Intellectual Product)\tnon-encapsulated part of cell (cellular anatomical entity)", + "output": "infection epstein-barr virus (Virus Diseases)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: P1-P6-bis(5'-adenosyl) pentaphosphate + H2O = AMP + adenosine 5'-tetraphosphate.\nConcepts: Personalized (Qualitative Concept)\tlateral spinothalamic tract (Spinothalamic Tracts)\tRetinoic Acid Early Transcript 1H (Amino Acid, Peptide, or Protein)\tbis(5'-adenosyl)-pentaphosphatase activity (nucleotide pyrophosphatase activity)\ttyramine anabolism (primary amino compound biosynthetic process)", + "output": "bis(5'-adenosyl)-pentaphosphatase activity (nucleotide pyrophosphatase activity)" + }, + { + "input": "Definition: Medical Device described as surgical trephines designed to percutaneously cut and remove (i.e., harvest) cylindrical sections of bone from donor sites. These instruments typically consist of a hollow cylinder with a circular-saw-like edge, a centering point, and a handheld, powered (e.g., electric) rotary surgical handpiece. Bone harvesting surgery trephines are used to obtain bone grafts (plugs) from donor sites (e.g., iliac crest, tibia, femur) used in autologous transplants for osseous reconstruction in procedures such as the repair of craniomaxillofacial bony defects.\nConcepts: thyroid hormone metabolism (cellular modified amino acid metabolic process)\tBone Harvesting Trephines (Trephines, Surgical)\tgrowth of symbiont in host cell (Organism Function)\tregulation of oxidative phosphorylation, NADH to ubiquinone (regulation of mitochondrial ATP synthesis coupled electron transport)\tExposure Daily Dose (Quantitative Concept)", + "output": "Bone Harvesting Trephines (Trephines, Surgical)" + }, + { + "input": "Definition: something described as a unit of measurement equal to 10 to the tenth power of entities per unit of volume equal to one liter.\nConcepts: 2: 148436296-148519244 (Chromosome 2 Physical Location)\tADCOFO11 (ADAS-Cog CDISC Version Questionnaire Question)\t10*10/l (Unit of Number Concentration)\tarchives (History)\tregulation of convergent extension involved in gastrulation (regulation of morphogenesis of an epithelium)", + "output": "10*10/l (Unit of Number Concentration)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify adenovirus, a DNA virus of the family Adenoviridae, by detecting the nucleic acid of the target virus. Some species of these viruses may cause acute respiratory, gastrointestinal, and urinary tract diseases; adenoviruses also cause latent infections of the tonsils and adenoids in children. Many species are likely to induce malignancies.\nConcepts: Synovitides (Abnormality of the synovia)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Adenovirus (Medical Device)\tSpectrophotometric measurement, NOS (Spectrometry)\tReporter Group (Conceptual Entity)\tNitrendipino (Dihydropyridines)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Adenovirus (Medical Device)" + }, + { + "input": "Definition: Biologically Active Substance described as molecule-sized pores in biomembranes that permit the passage of hydrophilic solutes such as inorganic ions, and the proteins that form such pores and control their permeability.\nConcepts: Activation Mutations (Mutation)\tChannels, Ion (Amino Acid, Peptide, or Protein)\tabscess perianal (Inflammation of large intestine)\tContingent negative variation (Cortical Evoked Potentials)\tRIF formula (Pharmacologic Substance)", + "output": "Channels, Ion (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as a photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I.\nConcepts: Rudivirus (Virus)\tnegative regulation of NAD(P)H oxidase activity (Organism Function)\tGrade 1 Neonatal Respiratory Distress Syndrome, Adverse Event (Finding)\tphotosynthetic electron transport in photosystem II (photosynthetic electron transport chain activity)\tLeukemia-Associated RhoGEF (Guanine Nucleotide Exchange Factors)", + "output": "photosynthetic electron transport in photosystem II (photosynthetic electron transport chain activity)" + }, + { + "input": "Definition: something described as the protein transport macromolecular complex of the chloroplast membrane that interacts with the precursor proteins and contains components of both the outer membrane and inner membrane complexes containing at least Toc75, Toc159, Toc34 and Tic110.\nConcepts: Ablation of Cardiac Accessory Pathway (Cardiac ablation)\tGrade 4 Tracheal stenosis (Finding)\tTOC-TIC supercomplex I (Cell Component)\tSPO11 (Amino Acid, Peptide, or Protein)\tDeoxyribonucleic acid, NOS (Nucleic Acids)", + "output": "TOC-TIC supercomplex I (Cell Component)" + }, + { + "input": "Definition: Liver described as fusion of the liver with the lung.\nConcepts: Have you felt embarrassed because of your urostomy (Intellectual Product)\talanine-glyoxylate transaminase activity (Molecular Function)\tHepatopulmonary fusion (Liver)\tHEMOPEXIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tGrb2-Shc complex location (Cell Component)", + "output": "Hepatopulmonary fusion (Liver)" + }, + { + "input": "Definition: Medical Device described as aid used for the administration of a drug by nose.\nConcepts: Adjudicator 2 (Professional or Occupational Group)\tNasal Applicator Device (Medical Device)\tProgressive sensorineural hearing loss and hypertrophic cardiomyopathy syndrome (Sensorineural Hearing Loss)\tBony pectoral girdle (Body Location or Region)\tvariolinum/small pox nosode (Organic Chemical)", + "output": "Nasal Applicator Device (Medical Device)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as an orally available inhibitor of lysine specific histone demethylase 1 (KDM1A; LSD1), with potential antineoplastic activity. Upon administration, iadademstat binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the di- and mono-methylated forms of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4, respectively. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. In addition, LSD1 demethylates mono- or di-methylated H3K9, which increases gene expression of tumor promoting genes; inhibition of LSD1 promotes H3K9 methylation and decreases transcription of these genes. LSD1, an enzyme belonging to the flavin adenine dinucleotide (FAD)-dependent amine oxidase family, is overexpressed in certain tumor cells and plays a key role in in the regulation of gene expression, tumor cell growth and survival.\nConcepts: Citrobacter Genomospecies 7 (Citrobacter freundii complex)\ttrans-N1-((1R,2S)-2-Phenylcyclopropyl)-1,4-cyclohexanediamine (Antineoplastic Enzyme Inhibitor)\tobstetrics (Specialties, Surgical)\tValue Set (Information Resources)\tEosinophilic dermal infiltration (Skin finding)", + "output": "trans-N1-((1R,2S)-2-Phenylcyclopropyl)-1,4-cyclohexanediamine (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: something described as a clinical syndrome resulting from direct or indirect muscle injury and subsequent release of myoglobin into the plasma.\nConcepts: SK-OV-3 (Experimental Model of Disease)\tDisorder of sclera, NOS (Sclera and episclera finding)\tcataract diabetic (Cataract)\tRHABDOMYOLYSIS (Disorder of skeletal muscle)\tmedium-chain fatty-acyl-CoA metabolic process (fatty-acyl-CoA metabolic process)", + "output": "RHABDOMYOLYSIS (Disorder of skeletal muscle)" + }, + { + "input": "Definition: Abnormality of the upper limb described as inability to elicit tendon reflexes in the upper limbs.\nConcepts: Areflexia of upper limbs (Abnormality of the upper limb)\tglucose-6-phosphate transmembrane transporter activity (Molecular Function)\tLeukemic Cell (Tumor cells, malignant)\tPatient Care Episodes (patient care)\tAbnormality of the heart valves (Heart)", + "output": "Areflexia of upper limbs (Abnormality of the upper limb)" + }, + { + "input": "Definition: Climate described as a type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall.\nConcepts: Cytomegalovirus, Rat (Virus)\thomeostasis of number of meristem cells (Organism Function)\tSeveral (Numerical descriptors)\tRenal Pelvis and Ureter Cancer pN2 TNM Finding v7 (Renal Pelvis and Ureter Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tDesert Climates (Natural Phenomenon or Process)", + "output": "Desert Climates (Natural Phenomenon or Process)" + }, + { + "input": "Definition: organic anion transmembrane transporter activity described as enables the transfer of 5'-adenylyl sulfate from one side of a membrane to the other.\nConcepts: glutamate breakdown to aspartate (glutamate catabolic process)\tTNF Receptor Associated Factor 4 (Amino Acid, Peptide, or Protein)\tSTIM1 Protein (Stromal Interaction Molecules)\tpentraxin binding (Molecular Function)\t5'-adenylyl sulfate transmembrane transporter activity (sulfur compound transmembrane transporter activity)", + "output": "5'-adenylyl sulfate transmembrane transporter activity (sulfur compound transmembrane transporter activity)" + }, + { + "input": "Definition: positive regulation of transport described as any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.\nConcepts: positive regulation of secretion (Cell Function)\txstng infclt 25min (Therapeutic or Preventive Procedure)\tLigase, Aspartate-Ammonia (Amide Synthases)\tCODAS SYNDROME (Syndrome)\tbladder disorders (Bladder finding)", + "output": "positive regulation of secretion (Cell Function)" + }, + { + "input": "Definition: Mast Cell Neoplasm described as the presence of an increased number of mast cells and CD34+ mast cell precursors in the body.\nConcepts: up regulation of terrequinone A biosynthetic process (positive regulation of small molecule metabolic process)\tmastocytoses (Skin Abnormalities)\tlateral nucleus of oculomotor nerve (Body Part, Organ, or Organ Component)\tSensations associated with urinary functions (Urinary functions)\tInguinal region, NOS (Lateral anterior abdominal surface region)", + "output": "mastocytoses (Skin Abnormalities)" + }, + { + "input": "Definition: regulation of mitotic spindle formation described as any process that activates or increases the frequency, rate or extent of mitotic spindle formation (spindle phase one).\nConcepts: NPI1C09 (Intellectual Product)\tglucuronoxylan xylanohydrolase activity (xylanase activity)\tfirst meiotic cell division (meiotic cell cycle process)\tpositive regulation of mitotic spindle formation (positive regulation of mitotic spindle elongation)\tFusion of gums (Congenital Abnormality)", + "output": "positive regulation of mitotic spindle formation (positive regulation of mitotic spindle elongation)" + }, + { + "input": "Definition: Medical Device described as clinical chemistry reagents used to determine several components in a sample of urine in a short period of time, typically several minutes (i.e., rapid tests). These reagents may be impregnated in one or more areas of a paper strip (reagent strip) that undergo a color change when reacted with specific substances. Urinary rapid-test multianalyte reagents are mostly used for simultaneous determination of two or more of the most important clinical substances in urine (e.g., protein, albumin, glucose, ketone bodies, occult blood, bilirubin, urobilinogen).\nConcepts: Axitinib-containing product (Substance with benzamide structure)\tOther Cytogenetic Analysis Abnormality Type (CPTAC Responses)\tNeedles, Suture, Ophthalmic (Ophthalmic device)\tImpregnated material (Basic Dosage Form Category)\tIVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Urine, Multianalyte (IVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Urine)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Urine, Multianalyte (IVD Test Reagent/Kits, Clinical Chemistry, Rapid Test, Urine)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a portion of the anterior hypothalamic area of the macaque defined on the basis of Nissl stain ( Paxinos-2009 ).\nConcepts: Disturbance in role performance (Nursing Assessment Entity)\tsulfating enzyme (Amino Acid, Peptide, or Protein)\tanterior part of the anterior hypothalamic area (Body Part, Organ, or Organ Component)\tFASN inhibitor TVB-2640 (Enzyme Inhibitor Drugs)\tDryers, Lyophilization (Dryers)", + "output": "anterior part of the anterior hypothalamic area (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Acetylcholinesterase Inhibitors described as the fourth-generation (also known as Novichok or A series) nerve agent A-234.\nConcepts: Kidney Synovial Sarcoma (synovial sarcoma)\tA-234 (Nerve Agents)\tSOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER, ADENINE NUCLEOTIDE TRANSLOCATOR), MEMBER 4 (Gene Mutation)\tRTEL1 protein, human (Amino Acid, Peptide, or Protein)\tPyrazoloacridine (Organic Chemical)", + "output": "A-234 (Nerve Agents)" + }, + { + "input": "Definition: Cell Component described as a protein complex that contains the cell adhesion molecules protocadherin-alpha-v4 and protocadherin-gamma-b4, and is involved in the regulation of protein localization to the plasma membrane.\nConcepts: ng/mL/(kg/m2) (Unit of concentration)\taffection (Mental Process)\tdorso-medial periolivary nucleus (Body Part, Organ, or Organ Component)\tPcdhga1-Pcdhgb4 complex location (protocadherin-alpha-protocadherin-gamma complex)\tZEDOARY OIL (Organic Chemical)", + "output": "Pcdhga1-Pcdhgb4 complex location (protocadherin-alpha-protocadherin-gamma complex)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.\nConcepts: kidney tubule (Nephrons)\tDHRD (Ligand Binding Protein Gene)\tAmelia (Limb Deformities, Congenital)\tSet of meninges (Membrane organ structure)\tCell Culture-Based Biosynthesis (Synthesis)", + "output": "kidney tubule (Nephrons)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in).\nConcepts: polar-amino acid-importing ATPase activity (ATPase-coupled amino acid transmembrane transporter activity)\tglands infections salivary (Disease or Syndrome)\tCYP2D6, K281del (Gene or Genome)\tGATA1-TAL1-TCF3-Lmo2 complex (protein-containing complex)\tMAID protocol (Therapeutic or Preventive Procedure)", + "output": "polar-amino acid-importing ATPase activity (ATPase-coupled amino acid transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a chromosome band present on 9q\nConcepts: BACILLUS MYCOIDES (Bacillus cereus group)\tADL0312B (ADCS-ADL MCI Questionnaire Question)\tpost synaptic density organization (Cell Function)\tAV Fistula Thrombosis (Disorder of surgical arteriovenous fistula)\t9q22.3 (Cell Component)", + "output": "9q22.3 (Cell Component)" + }, + { + "input": "Definition: Shellfish described as distributed worldwide, crustaceans are distinguished by having two pairs of antenna-like appendages in front of the mouth and other paired appendages near the mouth that act like jaws. Most species are marine, including shrimps and barnacles. Some, including crayfishes, live in freshwater habitats; others (e.g., sand fleas, land crabs, and sow bugs) live in moist terrestrial environments.\nConcepts: MET Tyrosine Kinase Inhibitor SAR125844 (Pharmacologic Substance)\tCD147-gamma-secretase complex (plasma membrane protein complex)\tGrowth Inhibitor (Pharmacologic Substance)\tIVD Panels, Human Genetics, Hearing Loss, Syndromic, Usher Syndrome, Mutation (IVD Panels, Human Genetics, Hearing Loss, Syndromic, Usher Syndrome)\tCrustacean - dietary (Shellfish - dietary)", + "output": "Crustacean - dietary (Shellfish - dietary)" + }, + { + "input": "Definition: Transient neutropenia described as transient neutropenia caused by an infection, such as with a virus, bacteria or protozoan.\nConcepts: Orbital Sarcoma pT3 TNM Finding v8 (Finding)\tIDH2 Wildtype (Laboratory or Test Result)\tRadiography Study File (Intellectual Product)\tInfection associated neutropenia (Transient neutropenia)\tSF-MPQ-2 - Sickening (Intellectual Product)", + "output": "Infection associated neutropenia (Transient neutropenia)" + }, + { + "input": "Definition: Spatial Concept described as physical location of KDR_Gene\nConcepts: I 131 Lipiodol (Indicator, Reagent, or Diagnostic Aid)\tFacilities, Residential (Thesaurus of Psychological Index Terms)\tmesonephric nephron development (nephron development)\t4: 55832690-55785577 (Chromosome 4 Physical Location)\tSlit-like opening of the exterior auditory meatus (Ear structure)", + "output": "4: 55832690-55785577 (Chromosome 4 Physical Location)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as autologous lymphocytes transduced with a retroviral vector encoding a chimeric antigen receptor (CAR) specific for the tumor-associated antigen human carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. Upon administration, the anti-CEA-CAR autologous T-lymphocytes target and bind to tumor cells expressing CEA, which results in the cytotoxic T-lymphocyte (CTL)-mediated cell killing of CEA-expressing tumor cells. CEA is overexpressed in various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121784\" active clinical trials using this agent.\nConcepts: Laboratory Test Reference Identifier (Intellectual Product)\tadenoid cystic carcinoma of esophagus (Neoplastic Process)\tdeviated septum (Disorder of nasal septum)\tAnti-CEA-CAR Autologous T Lymphocytes (therapeutic autologous lymphocytes)\tmeta AMSA (Antineoplastic Agents)", + "output": "Anti-CEA-CAR Autologous T Lymphocytes (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: Anatomical Abnormality described as fragmented appearance of the epiphyses of the 5th finger.\nConcepts: PCLC (Finding)\tFragmentation of the epiphyses of the 5th finger (Anatomical Abnormality)\tinterleukin 27 receptor subunit alpha (Cytokine Receptor Gene)\tDAD - Carry Out an Appropriate Telephone Conversation (DAD Questionnaire Question)\tChronic disease-related malnutrition (Nutrition Disorders)", + "output": "Fragmentation of the epiphyses of the 5th finger (Anatomical Abnormality)" + }, + { + "input": "Definition: Cell Function described as the process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.\nConcepts: Left Ventricular Mid Inferoseptal Segment (Body Part, Organ, or Organ Component)\tExtrahepatic Bile Duct Carcinosarcoma (Carcinosarcoma)\tArbacia punctulatas (Eukaryote)\tPost tp lymphprolif dis (Disorder of body system)\tdorsal spinal cord interneuron anterior axon guidance (Cell Function)", + "output": "dorsal spinal cord interneuron anterior axon guidance (Cell Function)" + }, + { + "input": "Definition: something described as an evaluation of interstitial fibrosis in a biological specimen.\nConcepts: Right ventricular hypoplasia (Hypoplasia of right heart)\tSkin Signet Ring Cell Basal Cell Carcinoma (Skin Basal Cell Carcinoma)\tLimited in Pursuing Hobbies or Leisure Activities (Findings-Based Question)\tCEV14 (Gene or Genome)\tInterstitial Fibrosis Assessment (Diagnostic Procedure)", + "output": "Interstitial Fibrosis Assessment (Diagnostic Procedure)" + }, + { + "input": "Definition: Duration described as the period of time in which the entity, activity, event or result is held to be true.\nConcepts: PSYCHIATRIC NONSPECIFIC (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Korean Edition)\tfocalDuration (Duration)\tGrade 1 Herpes simplex reactivation (Herpes Simplex Reactivation, CTCAE)\tCorpora Cavernosa (Body of penis)\tBenzoic acid, 3,4,5-trimethoxy-, 4-(acetyloxy)-6,10-dimethyl-3-(1-methylethyl)-11-oxabicyclo(8.1.0)undec-6-en-2-yl ester (Structural protein)", + "output": "focalDuration (Duration)" + }, + { + "input": "Definition: Acute inflammatory disease described as an acute inflammatory process that affects the nasopharynx. It is caused by viruses. Signs and symptoms include fever, coughing, sneezing, and sore throat.\nConcepts: EMA (Organization)\tWheel of Wheelchair (Manufactured Object)\tInadequate vitamin intake (Nutrient intake - finding)\tviral upper respiratory infection (Upper Respiratory Infections)\tacyl-CoA:16-epivellosimine O-acetyltransferase (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "viral upper respiratory infection (Upper Respiratory Infections)" + }, + { + "input": "Definition: Records described as compilations of data on hospital activities and programs; excludes patient medical records.\nConcepts: CD13 Expressing Cell Count (Cell Count)\thospital records (Records)\tDysplasia of the femoral head (Abnormality of the femoral head)\tOrthoethoxybenzoic Acid Dental Cement (Zinc Oxide-Eugenol Cement)\tanti-EGFR monoclonal antibody RO5083945 (Antineoplastic Antibody)", + "output": "hospital records (Records)" + }, + { + "input": "Definition: something described as a chromosome band present on 10q\nConcepts: Adonis vernalis / pheasant's eye (Organic Chemical)\t10q26.13 (Chromosome band)\tRecurrent Large Pleural Effusion (Large Pleural Effusion)\tKDM1A (Gene or Genome)\tMy doctor/nurse and I work together to make decisions (Intellectual Product)", + "output": "10q26.13 (Chromosome band)" + }, + { + "input": "Definition: Disorder of the genitourinary system described as a benign or malignant neoplasm that affects the uterine corpus. Representative examples of benign neoplasms include leiomyoma, adenomyoma, endometrial stromal nodule, and endometrial polyp. Representative examples of malignant neoplasms include endometrial carcinoma, adenosarcoma, carcinosarcoma, and leiomyosarcoma.\nConcepts: tyrosylprotein sulfotransferase activity (sulfotransferase activity)\tnail detachment (Dystrophia unguium)\tLower Lobe (Body Part, Organ, or Organ Component)\tCorpus Uteri Neoplasm (Disorder of pelvis)\tAnti-ppUL38 Antibody (Amino Acid, Peptide, or Protein)", + "output": "Corpus Uteri Neoplasm (Disorder of pelvis)" + }, + { + "input": "Definition: Therapeutic Uses described as drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.\nConcepts: Glottic Cancer pT2 TNM Finding v6 and v7 (Glottic Cancer Pathologic Primary Tumor TNM Finding v7)\trenal drug (Pharmaceutical Preparations)\tGrade 2 Duodenal Hemorrhage, CTCAE (Finding)\tLowenstein-Jensen Medium (Indicator, Reagent, or Diagnostic Aid)\t3p14.3-p14.2 (Chromosome band)", + "output": "renal drug (Pharmaceutical Preparations)" + }, + { + "input": "Definition: Medication Management described as the distribution, sale, or transfer of a drug not pursuant to a specific prescription.\nConcepts: Medication Distribution (Therapeutic or Preventive Procedure)\tKIAA1680 (Gene or Genome)\tpyrimidine (Nucleic Acid, Nucleoside, or Nucleotide)\tAPPLIANCE, FIXATION, NAIL/BLADE/PLATE COMBINATION, MULTIPLE COMPONENT, METAL COMPOSITE (Medical Device)\tplatelet alpha-granule lumen (Cell Component)", + "output": "Medication Distribution (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Glandular Cell Intraepithelial Neoplasia described as a pre-cancerous, non-invasive pancreatic epithelial neoplasm that arises from and is confined to the pancreatic ducts. It is a papillary or flat neoplasm that usually measures less than 5 mm in diameter.\nConcepts: 4-(hexadecylamino)benzoic acid (Antilipidemic Agent)\tMissing Test Results (Test Result Inaccurate Medical Device Problem)\tguideline practice (Intellectual Product)\tPancreatic intraepithelial neoplasia (Borderline Exocrine Pancreatic Neoplasm)\tthromboembolic event (Hematology)", + "output": "Pancreatic intraepithelial neoplasia (Borderline Exocrine Pancreatic Neoplasm)" + }, + { + "input": "Definition: something described as a benign, well-circumscribed, bone-forming neoplasm predominantly composed of lamellar bone. It usually arises from the calvarial, facial, or jaw bones. It is usually asymptomatic but it may cause local swelling or obstruction of the paranasal sinuses. Asymptomatic cases have an indolent clinical course.\nConcepts: Receptor, Opiate (Neuropeptide Receptor)\tSDTM-SZFATSCD (Intellectual Product)\tpancreatic bud formation (animal organ formation)\tOsteoma (Malignant neoplasm musculoskeletal)\tFrenulum (General anatomical term)", + "output": "Osteoma (Malignant neoplasm musculoskeletal)" + }, + { + "input": "Definition: something described as the maximum excretion rate divided by the weight.\nConcepts: WD4H1 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tImaging, Single Particle (Laboratory Procedure)\trisk for infection (At risk of disease)\tCongenital hypoplasia of cerebellum (Congenital hypoplasia of part of brain)\tMaximum Observed Excretion Rate Normalized by Weight (Quantitative Concept)", + "output": "Maximum Observed Excretion Rate Normalized by Weight (Quantitative Concept)" + }, + { + "input": "Definition: something described as a class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control.\nConcepts: Lysosome, NOS (Organelles)\tregulation of amino acid export (regulation of amino acid transmembrane transport)\tINPC (Classification)\tDNA Topoisomerase 2-Alpha Protein Variant (Cell or Molecular Dysfunction)\tCPS1 (carbamoyl-phosphate synthetase 1) deficiency (Metabolic Diseases)", + "output": "Lysosome, NOS (Organelles)" + }, + { + "input": "Definition: something described as a measurement of the Clostridium difficile toxin B (tcdB) DNA in a biological specimen.\nConcepts: Xenorhabdus Thomas and Poinar 1979 (Approved Lists 1980) emend. Akhurst 1983 (Enterobacteriaceae)\tClostridium difficile tcdB DNA (Laboratory Procedure)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Urinary Bladder (IVD Test Reagent/Kits, Immunoassay, Tumor Marker)\tfatty-acyl group transport (Cell Function)\tNotch signaling pathway inhibitor MK0752 (Signal Transduction Inhibitor)", + "output": "Clostridium difficile tcdB DNA (Laboratory Procedure)" + }, + { + "input": "Definition: Functional Concept described as set of measurements and inspections taken to verify that performance of equipment and procedures remains within specified limits.\nConcepts: ostomy irrigation edkshn (Teaching how to perform procedure)\tpM1 Cancer of the Lung v6 (Finding)\tMobility of several joints (Organism Function)\tWas thorough (Clinical or Research Assessment Question)\tQA Report (Functional Concept)", + "output": "QA Report (Functional Concept)" + }, + { + "input": "Definition: something described as in a paper submission, listings of data that may be organized by domain (type of data) or by subject. See also eCRT.\nConcepts: Fanconi Anemia, Complementation Group N Gene Mutation (Fanconi Anemia Complementation Group Gene Mutation)\tSmooth Muscle Myosins (Amino Acid, Peptide, or Protein)\tcase report tabulations (Intellectual Product)\tA-Microtubule (Cilium Microtubule)\tI know which options are available to me (Intellectual Product)", + "output": "case report tabulations (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as programmer/testers designed for noninvasively testing and/or changing (i.e., programming) the drug-delivery rate of implanted infusion pumps. These devices typically consist of a computerized unit, including a programming head that can interact with the implanted infusion pump, sending programming signals to the pump and receiving status information from it. Implantable infusion pump programmer/testers are used during patient checkup to test and/or change the drug-delivery rate of the implanted pump (e.g., intrathecal delivery pumps); they are usually appropriate only for a particular set of implantable infusion pumps.\nConcepts: N-(4-Methoxyphenyl)retinamide (Retinoids)\tBat Wing Sign (Radiologic finding)\tGrade 1 Hemoglobin increased (Hemoglobin Increased, CTCAE)\tProgrammer/Testers, Implantable Infusion Pump (Medical Device)\tAuxilin (Vesicular Transport Proteins)", + "output": "Programmer/Testers, Implantable Infusion Pump (Medical Device)" + }, + { + "input": "Definition: something described as this gene plays a role in chromosome instability in embryonic cells and oocytes.\nConcepts: Elevated urinary dopamine (Finding)\tAdGMCAIX-transduced Autologous Dendritic Cells (Antineoplastic Immune Cell)\tH1-8 Gene (Gene or Genome)\tPI3K Inhibitor GSK1059615 (Organic Chemical)\tOxytocic Agent (Oxytocics)", + "output": "H1-8 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale (HAQ-DI Without VAS) Hygiene: Are you able to take a tub bath?\nConcepts: Multifactor Dimensionality Reduction (Intellectual Product)\tREPET MOTION DIS (Injury by mechanism)\tHAQ-DI Without VAS - Take a Tub Bath (HAQ-DI Without VAS Questionnaire Question)\tAbnormality of internal jugular vein (Anatomical Abnormality)\tautologous anti-BCMA-CAR-4-1BB-CD3zeta-expressing CD4+/CD8+ T lymphocytes JCARH125 (Cell)", + "output": "HAQ-DI Without VAS - Take a Tub Bath (HAQ-DI Without VAS Questionnaire Question)" + }, + { + "input": "Definition: something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated\nConcepts: INSUFFLATOR, AUTOMATIC CARBON-DIOXIDE FOR ENDOSCOPE (Medical Device)\toxidized protein catabolic process (Molecular Function)\tGrade 1 Brachial Plexopathy, CTCAE (Brachial Plexopathy, CTCAE 5.0)\tbenzoic hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor)\tfemale germline ring canal inner rim (Cell Component)", + "output": "Grade 1 Brachial Plexopathy, CTCAE (Brachial Plexopathy, CTCAE 5.0)" + }, + { + "input": "Definition: TSCC Questionnaire Question described as trauma Symptom Checklist for Children (TSCC) Daydreaming.\nConcepts: TSCC - Daydreaming (TSCC Questionnaire Question)\tSplicing Factor U2AF 35 kDa Subunit (RNA-Binding Proteins)\tHereditary Hyperbilirubinemia (Disease or Syndrome)\tSagittal synostosis (Skull)\tstage IIA distal bile duct cancer AJCC v7 (Distal Bile Duct Cancer by AJCC v7 Stage)", + "output": "TSCC - Daydreaming (TSCC Questionnaire Question)" + }, + { + "input": "Definition: Structure of alveolar epithelium described as cuboidal epithelial cells that line the PULMONARY ALVEOLI and produce and secret PULMONARY SURFACTANTS.\nConcepts: NFKB2 Gene Product (TRANSCRIPTION FACTOR)\tLAGE-2B Positive (Positive Laboratory Test Result)\t1: 85455604-85443954 (Chromosome 1 Physical Location)\tAlveolar type II cell (Alveolar Epithelial Cells)\tNPI - Anxiety Frequency (NPI Questionnaire Question)", + "output": "Alveolar type II cell (Alveolar Epithelial Cells)" + }, + { + "input": "Definition: Tissue Differentiation described as a morphologic finding that indicates the presence of myofibroblastic differentiation in a cellular infiltrate of a tissue sample.\nConcepts: TAPE, TELEVISION & VIDEO, CLOSED-CIRCUIT, USED DURING ENDOSCOPIC PROCEDURE (Medical Device)\tMyofibroblastic Differentiation (Finding)\tAbsent end part of the long bone of hand (Absent epiphyses)\tBaseline Nausea and Vomiting Score 3 (Baseline Nausea and Vomiting Scale)\tUbiquitin Carboxyl-Terminal Hydrolase (Parkinson Disease Associated Proteins)", + "output": "Myofibroblastic Differentiation (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs that bind to and activate excitatory amino acid receptors.\nConcepts: cataract (Other cataract)\tAA AGON EXCITATORY (Pharmacologic Substance)\tDrosha Ribonuclease III Gene (Gene or Genome)\tNPI1C03 (Intellectual Product)\tSDTM-DRSTAT (Intellectual Product)", + "output": "AA AGON EXCITATORY (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as human TFIIH Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, ERCC2, and ERCC3, encode six subunits of the nuclear core-TFIIH basal transcription factor. These subunits are involved in transcription-coupled DNA nucleotide excision repair, and basal RNA polymerase II transcription when complexed to CAK (CDK7/Cyclin H/MAT1). Phosphorylated 548-aa 62-kDa GTF2H1 contains 2 BSD domains. The 395-aa 44-kDa GTF2H2 contains a C4-type zinc finger and a VWFA domain. The N-terminus interacts with and regulates XPD, while the C-terminus promotes escape of RNAPII from the promoter. GTF2H2 also interacts with XPB, p62, and p34. Containing a C4-type zinc finger, 303-aa 34-kDa GTF2H3 anchors XPB. ATP-dependent 760-aa 87-kDa ERCC2 DNA helicase anchors CAK to core-TFIIH; interaction with p44 stimulates helicase activity. ERCC3 is a 782-aa 89-kDa ATP-dependent DNA helicase.\nConcepts: mugs (Exposure to attack by other person)\tneck anatomy (Scalp and/or neck structure)\tCapsaicinoid (Bioactive Food Component)\tTFIIH Core Subunit Gene (TFIIH Subunit Gene)\tmonitoring system (Clinical Recorders and Monitors)", + "output": "TFIIH Core Subunit Gene (TFIIH Subunit Gene)" + }, + { + "input": "Definition: Duplication of phalanx of 2nd finger described as a partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the phalanges of the 2nd finger. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.\nConcepts: Talimogene Laherparepvec Regimen (Therapeutic or Preventive Procedure)\tBilateral Breast Carcinoma (Breast Carcinoma)\tPartial duplication of the bones of the index finger (Duplication of phalanx of 2nd finger)\tpositive regulation of cytochrome c oxidase activity (positive regulation of cation transmembrane transport)\tModified Glasgow coma score (Component of Glasgow coma scale)", + "output": "Partial duplication of the bones of the index finger (Duplication of phalanx of 2nd finger)" + }, + { + "input": "Definition: somatic afferent nerve described as unmyelinated sensory axons in peripheral nerves which carry slow pain responses; attached nociceptors are thought to be activated by a chemical released into the extracellular fluid as a result of tissue damage; widely distributed in deep tissue as well as skin.\nConcepts: Brompheniramine Maleate (Histamine H1 Antagonists)\tC Fiber (somatic afferent nerve)\tStage IVC Nasopharyngeal Throat Cancer (Stage IVC Pharyngeal Carcinoma)\tExtra-osseous Ewing's sarcoma NOS (Malignant musculoskeletal and connective tissue neoplasms)\tBenzoic acid, 3,4,5-trimethoxy-, (tetrahydro-1H-1,4-diazepine-1,4(5H)-diyl)di-3,1-propanediyl ester (Other vasodilators used in cardiac diseases in ATC)", + "output": "C Fiber (somatic afferent nerve)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle.\nConcepts: 1,5-anhydro-D-fructose anabolism (organic cyclic compound biosynthetic process)\tresponse to transition metal nanoparticle (response to chemical)\tlarge bowel (Lower Gastrointestinal Tract)\tDisinfect, Failure To (Medical Device Disinfection or Sterilization Issue)\tnucleophosmid (Amino Acid, Peptide, or Protein)", + "output": "response to transition metal nanoparticle (response to chemical)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: [citrate (pro-3S)-lyase](acetyl form) + H2O = [citrate (pro-3S)-lyase](thiol form) + acetate.\nConcepts: citrate-(pro-3S)-lyase thioesterase activity (Molecular Function)\tnegative regulation of mitotic cohesin loading (regulation of mitotic cohesin loading)\tGreig syndrome (MISCELLANEOUS MULTIPLE MALFORMATION SYNDROMES)\tStage IVB Nasal Cavity and Paranasal Sinus Squamous Cell Cancer (Stage IV Nasal Cavity and Paranasal Sinus Squamous Cell Carcinoma AJCC v7)\tPutative Uncharacterized Protein KIAA0125 (Biologically Active Substance)", + "output": "citrate-(pro-3S)-lyase thioesterase activity (Molecular Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as measures to limit noise and conversation in the patient's room; keep light levels low and minimise tactile stimulation.\nConcepts: Anterior Gradient 3, Xenopus, Homolog of Gene (Gene or Genome)\tPAXIP1 associated glutamate rich protein 1 (Transcription Regulation Gene)\tribonuclease E activity (ribonuclease activity)\tPhosphatidylinositol-3,4,5-Trisphosphate-Dependent Rac Exchange Factor 2 wt Allele (Gene or Genome)\tMinimising environmental stimulation (Environmental care procedure)", + "output": "Minimising environmental stimulation (Environmental care procedure)" + }, + { + "input": "Definition: racemase and epimerase activity described as catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule.\nConcepts: racemase and epimerase activity, acting on carbohydrates and derivatives (racemase and epimerase activity)\tGrade 2 Forced expiratory volume decreased (Forced Expiratory Volume Decreased, CTCAE)\tNCCN Guidelines Version 1.2011 Distress Management Problem List Screening Tool (Research or Clinical Assessment Tool)\tgibberellin A12,oxoglutarate:oxygen oxidoreductase activity (Molecular Function)\tCyclic peptides (Macrocyclic Compounds)", + "output": "racemase and epimerase activity, acting on carbohydrates and derivatives (racemase and epimerase activity)" + }, + { + "input": "Definition: Structure of ligament of elbow joint described as ligament of elbow joint, each instance of which is a fibrous band attached to inferior border of radial notch on some ulna and to neck of some radius.\nConcepts: Ligamentum quadratum (Structure of ligament of elbow joint)\tNon-T Non-B CALLA Positive Adult Acute Lymphoblastic Leukemia (Adult Non-T Non-B Acute Lymphoblastic Leukemia)\tACID, PYRUVIC, ENZYMATIC (Indicator, Reagent, or Diagnostic Aid)\tGenus Ebola-like viruses (Virus)\tTablet 12 Hour Sustained Release Dosage Form (Biomedical or Dental Material)", + "output": "Ligamentum quadratum (Structure of ligament of elbow joint)" + }, + { + "input": "Definition: something described as a surgical drape and drape accessories is a device made of natural or synthetic materials intended to be used as a protective patient covering, such as to isolate a site of surgical incision from microbial and other contamination. The device includes a plastic wound protector that may adhere to the skin around a surgical incision or be placed in a wound to cover its exposed edges, and a latex drape with a self-retaining finger cot that is intended to allow repeated insertion of the surgeon's finger into the rectum during performance of a transurethral prostatectomy.\nConcepts: DRAPE, PATIENT, OPHTHALMIC (Medical Device)\tMalignant Squamous Cell Neoplasm (Neoplasms)\tATRIAL TRIGEMINY (Disease or Syndrome)\tIndium In 111-Autologous CMV-pp65-LAMP mRNA Loaded Dendritic Cells (Cell)\tScrewdrivers, Surgical, Bone/Bone Prosthesis (Medical Device)", + "output": "DRAPE, PATIENT, OPHTHALMIC (Medical Device)" + }, + { + "input": "Definition: Agent Combination Not Indexed in Open Clinical Trials described as an herbal combination of two plants, devil's claw (Harpagophytum procumbens) and jambul (Eugenia jambolana) that may be administered both orally and topically in various formulations. Devil's claw has been used as a tonic, as a hypoglycemic, to cleanse the lymph system, and in the treatment of arthritis and rheumatism. This agent may have anti-inflammatory and analgesic properties, possibly due to the presence of antioxidants, phenols, tannins, triterpenoids and volatile oils. Jambul seeds and fruits have important carminative and astringent properties and may reduce blood sugar levels. This agent contains glucosides, jamboline and ellagic acid which may check the conversion of starch into sugar.\nConcepts: data entry (Entry)\tHILAR (Anatomy Qualifier)\tosteogenesis imperfecta-optic atrophy-retinopathy-developmental delay syndrome (Disease or Syndrome)\tDevil's Foot/Jambul (Agent Combination Not Indexed in Open Clinical Trials)\tMesothelial neoplasms (Malignant Neoplasms)", + "output": "Devil's Foot/Jambul (Agent Combination Not Indexed in Open Clinical Trials)" + }, + { + "input": "Definition: something described as the determination of the ratio of lipocalin-2 compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Lipocalin-2 to Creatinine Ratio Measurement (Laboratory Procedure)\tresponse to peptidoglycan (response to organonitrogen compound)\tPost-Kala-azar dermal leishman (Sequelae of disorders classified by disorder-system)\tRanBP2-Like and GRIP Domain-Containing Protein 3 (Amino Acid, Peptide, or Protein)\tR3601TC (Intellectual Product)", + "output": "Lipocalin-2 to Creatinine Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Triangular shaped phalanges of the 4th finger described as triangular shaped proximal phalanx of the 4th (ring) finger. A triangular or so called delta shaped phalanx is a typical result after a bracket epiphysis of the affected phalanx.\nConcepts: PR - Time to Meaningful Pain Relief (PR Questionnaire Question)\tTriangular shaped innermost bone of the ring finger (Triangular shaped proximal phalanges of the hand)\tNecrosis pituitary (Pituitary Diseases)\tPlatelet-Derived Growth Factor Beta Polypeptide Gene Mutation (Cell or Molecular Dysfunction)\tDisease, Machado-Joseph (Cerebellar Ataxia, Late Onset)", + "output": "Triangular shaped innermost bone of the ring finger (Triangular shaped proximal phalanges of the hand)" + }, + { + "input": "Definition: something described as a variant of infiltrating bladder urothelial carcinoma. It is characterized by a nested growth pattern.\nConcepts: Anti-PD-1 Monoclonal Antibody Sym021 (Immunologic Factor)\tcongenital malformations of musculoskeletal system (Congenital malformations of musculoskeletal system, not elsewhere classified)\tElectrocardiography/Vital Signs Monitors (Medical Device)\tRacquet Sport (Sports)\tNested urothelial carcinoma (Infiltrating Bladder Urothelial Carcinoma)", + "output": "Nested urothelial carcinoma (Infiltrating Bladder Urothelial Carcinoma)" + }, + { + "input": "Definition: Chemical procedure described as measurements of light resulting from CHEMILUMINESCENCE.\nConcepts: Sociopathic personality disorder (Mental or Behavioral Dysfunction)\tInhibitor, Sodium Channel (Cardiovascular Agents)\tresponse to manganese-induced ER stress (response to endoplasmic reticulum stress)\tShortness of Breath (Research or Clinical Assessment Tool)\tChemoluminescence Measurement (Chemical method)", + "output": "Chemoluminescence Measurement (Chemical method)" + }, + { + "input": "Definition: Surgical Instruments described as a manual gastroenterology-urology surgical instrument and accessories is a device designed to be used for gastroenterological and urological surgical procedures. The device may be nonpowered, hand-held, or hand-manipulated. Manual gastroenterology-urology surgical instruments include the biopsy forceps cover, biopsy tray without biopsy instruments, line clamp, nonpowered rectal probe, nonelectrical clamp, colostomy spur-crushers, locking device for intestinal clamp, needle holder, gastro-urology hook, gastro-urology probe and director, nonself-retaining retractor, laparotomy rings, nonelectrical snare, rectal specula, bladder neck spreader, self-retaining retractor, and scoop.\nConcepts: Fossa epigastrica (Abdomen)\tPlunger Device (Device Component or Accessory)\tSCOOP (Medical Device)\tautophagic vacuole (Vacuole)\tRothia mucilaginosa (Bergan and Kocur 1982) Collins et al. 2000 (Bacterium)", + "output": "SCOOP (Medical Device)" + }, + { + "input": "Definition: EORTC QLQ-C30 Version 3 Questionnaire Question described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Have you lacked appetite?\nConcepts: Technetium Tc-99m Hydroxydiphosphonate (Pharmacologic Substance)\tCubic Millimeter per Square Millimeter per Year (Unit of Volumetric Flow Rate)\tEOR0113 (EORTC QLQ-C30 Version 3 Questionnaire Question)\tMilliliter per 100 Milliliters (Potency Unit)\tHuman Figures Drawing (Diagnostic Procedure)", + "output": "EOR0113 (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated\nConcepts: Appendix Neuroendocrine Tumor pT4 TNM Finding v8 (Finding)\tFloating-point (DataType)\tTesticular Cancer cN1 TNM Finding v8 (Testicular Cancer Clinical Regional Lymph Nodes TNM Finding v8)\tGrade 4 Dehydration (Dehydration, CTCAE)\tCRESYL VIOLET ACETATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "Grade 4 Dehydration (Dehydration, CTCAE)" + }, + { + "input": "Definition: Finding described as patchy (irregular) increase in bone density of one or more of the phalanges of the fifth toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.\nConcepts: Knife, device (Cutlery)\tPatchy sclerosis of 5th toe phalanx (Patchy sclerosis of toe phalanx)\tDermatome Carriers (Medical Device)\tNeoplasm of the Thyroid Gland (Thyroid Diseases)\tBone of Extremity (Regional bone structure)", + "output": "Patchy sclerosis of 5th toe phalanx (Patchy sclerosis of toe phalanx)" + }, + { + "input": "Definition: Medical Device described as aorta vascular stents designed to be expanded by the application of a constant radial pressure to the artery walls using a low-pressure balloon after delivery through an appropriate stent delivery system. These endoprostheses are usually metallic (e.g., stainless steel) stents; they are available in a variety of lengths (e.g., from 4 to 25 cm/1.5 to 10 inches) with maximum diameter after expansion about 50 mm (2 inches). Balloon-expandable aorta stents are intended to form a scaffold that holds and reinforces the aorta open to prevent restenosis; they are usually mounted on balloon delivery catheters. Stents intended to treat aorta (type A) dissections (that may be combined with placement of aorta prostheses during open surgery) and for lower aorta dissections (usually performed percutaneously through the vasculature) are available.\nConcepts: Excision Repair Cross Complementing-Group (Amino Acid, Peptide, or Protein)\tStents, Vascular, Aorta, Balloon Expandable (Medical Device)\tcell proliferation involved in atrioventricular junction remodeling (cell proliferation involved in heart morphogenesis)\tskin sheep (Pressure Relief Pads)\tcellular response to 1,4-Butanediamine (cellular response to organonitrogen compound)", + "output": "Stents, Vascular, Aorta, Balloon Expandable (Medical Device)" + }, + { + "input": "Definition: Abnormality of urine homeostasis described as an abnormally high level of uric acid in the urine.\nConcepts: Uric acid concentration in urine above normal (Abnormal composition of urine)\tfatty liver acute (Steatohepatitis)\tRecurrent Non-Cutaneous Melanoma (Non-Cutaneous Melanoma)\tFGFR2(IIIb) Overexpression (Finding)\tIVD Test Reagent/Kits, Serology, Virus, Retrovirus, HIV-1, Antibody, Confirmatory (Medical Device)", + "output": "Uric acid concentration in urine above normal (Abnormal composition of urine)" + }, + { + "input": "Definition: Mammal described as a member of the Chinchillidae family of crepuscular rodents native to the Andes mountains in South America. These animals are highly prized for their fur and are used in biomedical research for auditory system research as well as bacterial infections caused by Listeria, Yersinia and Pseudomonas.\nConcepts: Unhappiness (Level of depression)\tIntrahepatic Bile Duct Cancer pT2b TNM Finding v7 (Intrahepatic Bile Duct Cancer pT2 TNM Finding v7)\tWild chinchilla (Rodent)\tDefinedCriterionGroupOptionRelationship.pauseQuantity (Pause Quantity)\tDischarge from virtual ward (Health Care Activity)", + "output": "Wild chinchilla (Rodent)" + }, + { + "input": "Definition: Qualitative Concept described as deviation or aberration in the practical implementation of standard empirical procedures, distinct from MEDICAL ERRORS and SCIENTIFIC MISCONDUCT.\nConcepts: inositol (Carbohydrates)\tVisuospatial perception (Mental Process)\tactivation of apoptotic process of metanephric collecting duct development (positive regulation of metanephros development)\tMycobacterium malmoense Schroder and Juhlin 1977 (Slow growing mycobacteria)\tError, Scientific Experimental (Qualitative Concept)", + "output": "Error, Scientific Experimental (Qualitative Concept)" + }, + { + "input": "Definition: Finding described as effusion with physiologic consequences\nConcepts: enzyme active site formation via O-phospho-L-serine (peptidyl-serine phosphorylation)\tregulation of acetylcholine-gated cation channel activity (regulation of cation channel activity)\tGrade 3 Pericardial Effusion, CTCAE (Finding)\tmolecular psychobiology (Biomedical Occupation or Discipline)\tX-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (Genetic Diseases, X-Linked)", + "output": "Grade 3 Pericardial Effusion, CTCAE (Finding)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism.\nConcepts: retroviral integrase activity (Molecular Function)\tRNA-binding protein, IRP-2 (Aconitate Hydratase)\tIVD Test Reagent/Kits, Microbiology, Parasite, Identification, Trypanosoma Species (Medical Device)\tContrast End (Identifier)\tOPTN protein, human (Regulatory Protein)", + "output": "retroviral integrase activity (Molecular Function)" + }, + { + "input": "Definition: Aromatase Inhibitors described as a family of drugs that decrease the production of sex hormones (estrogen or testosterone) and slow the growth of tumors that need sex hormones to grow.\nConcepts: Ovarian stromal tumor (Neoplasm of uncertain behavior of female genital organ)\tAcinetobacter sp. phenon 4 (Acinetobacter)\tTherapeutic (General Qualifier)\tNon-Steroidal Aromatase Inhibitor (Aromatase Inhibitors)\tExtent of Sexual Activity (Intellectual Product)", + "output": "Non-Steroidal Aromatase Inhibitor (Aromatase Inhibitors)" + }, + { + "input": "Definition: Finding described as any deviation from the normal concentration of ornithine in the cerebrospinal fluid.\nConcepts: It took longer than I expected (Intellectual Product)\tAbnormal CSF ornithine concentration (Finding)\tTNB-383B (Antineoplastic Antibody)\tAnalytical Ultracentrifugation (Laboratory Procedure)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum, Antibody (Medical Device)", + "output": "Abnormal CSF ornithine concentration (Finding)" + }, + { + "input": "Definition: Neonatal Adverse Event described as an adverse event in a newborn characterized by hemorrhage originating at any site located within the gastrointestinal tract.\nConcepts: Neonatal Gastrointestinal Bleeding, AE (Finding)\tCiclosporina (Cyclosporine and cyclosporine derivative)\tComel-Netherton syndrome (Disease or Syndrome)\tAble to Hear without Hearing Aids (Clinical or Research Assessment Answer)\tUterine Pain, CTCAE 5 (Reproductive System and Breast Disorders, CTCAE)", + "output": "Neonatal Gastrointestinal Bleeding, AE (Finding)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of TRAIL-activated apoptotic signaling pathway.\nConcepts: up regulation of TRAIL-activated extrinsic apoptotic signaling pathway (Molecular Function)\tAVL02-List B Word 11 (AVLT-REY Functional Test Question)\tHas Target (Idea or Concept)\tregulation of chorionic trophoblast cell proliferation (regulation of cell population proliferation)\tNORMAL FLORA (Specimen related microbial interpretation)", + "output": "up regulation of TRAIL-activated extrinsic apoptotic signaling pathway (Molecular Function)" + }, + { + "input": "Definition: Broad phalanges of the hand described as increased width of the phalanges of the 4th finger.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Limit: Walking Fast 1 Mile (Intellectual Product)\tBroad phalanges of the 4th finger (Broad phalanges of the hand)\tPlanned Time Point Number (Intellectual Product)\tRural Health Service (Health Care Activity)\tNRP Measurement (Protein or Enzyme Type Measurement)", + "output": "Broad phalanges of the 4th finger (Broad phalanges of the hand)" + }, + { + "input": "Definition: Intellectual Product described as a subjective answer indicating the opinion of not being skilled.\nConcepts: Tyro7 Gene Amplification (Cell or Molecular Dysfunction)\tGrade 1 Atrial flutter (Finding)\tnegative regulation of toll-like receptor 4 signalling pathway (negative regulation of toll-like receptor signaling pathway)\tguanine nucleotide-releasing factor 2 protein, human (Amino Acid, Peptide, or Protein)\tNot at All Good (Intellectual Product)", + "output": "Not at All Good (Intellectual Product)" + }, + { + "input": "Definition: Anthelmintics described as potentially toxic, but effective antischistosomal agent, it is a metabolite of LUCANTHONE.\nConcepts: HYC (Thioxanthenes)\tup-regulation of white fat cell proliferation (positive regulation of fat cell proliferation)\twww-other (Publications)\t13-lipoxin reductase activity (Molecular Function)\tBougies, Urethra, Filiform (Urethral bougie)", + "output": "HYC (Thioxanthenes)" + }, + { + "input": "Definition: Gastric function described as a digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again.\nConcepts: Testicular Yolk Sac Tumor, Hepatoid Pattern (Neoplastic Process)\tKIT p.S840I (KIT Protein Variant)\tArterial Embolism (Non-site specific embolism and thrombosis)\tGap b3 (Receptor)\tRegurgitation and rechewing (Digestion)", + "output": "Regurgitation and rechewing (Digestion)" + }, + { + "input": "Definition: Cell Function described as any intercellular signaling process that reduces the frequency or extent of binding of a cognate ligand to an intracellular or transmembrane receptor to initiate an intracellular response. Receptor inhibition is involved in numerous processes, including metabolism, immune response, sexual development, nervous system function, and regulation of circadian rhythms, mood and behavior.\nConcepts: Negative Regulation of Receptor Activation (Cell Function)\tRestrictive ventric sept def (Ventricular Septal Defects)\t2D (Dimensionality)\tPESCAT (Classification)\t17q24.2 (Chromosome band)", + "output": "Negative Regulation of Receptor Activation (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the cardiovascular system findings domain.\nConcepts: u[IU]/ml/(mg/kg/d) (Unit of concentration)\tSupplemental Qualifiers for Cardiovascular System Findings (Supplemental Qualifiers Tabulation Dataset)\t(+)-(7S,9S)-9-Acetyl-9-amino-7-((2-deoxy-beta-D-erythro-pentopyranosyl)oxy)- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione (Anthracycline Antibiotics)\tAssays, Cell Migration (Laboratory Procedure)\tGlutamic Acid Decarboxylase 1 Measurement (Protein or Enzyme Type Measurement)", + "output": "Supplemental Qualifiers for Cardiovascular System Findings (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: something described as hamilton Anxiety Rating Scale test name.\nConcepts: YTTRIUM Y-90 IBRITUMOMAB TIUXETAN (Radioimmunoconjugates)\tcnidium monnieri/she chuang (Oriental herbs and natural substances letter C)\tHCV DNA Vaccine INO-8000 (Pharmacologic Substance)\tQS-HAMA TEST (CDISC Clinical Classification Terminology)\tdorsal tegmental tract (midbrain related medial forebrain bundle system)", + "output": "QS-HAMA TEST (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Disease or Syndrome described as nephrotic syndrome presenting within the first three months of life, and which is associated with an infectious process.\nConcepts: Fungus, antigenic product (Specific antigen)\tIVD Test Reagent/Kits, Serology, Virus, Influenza B, Antibody (IVD Test Reagent/Kits, Serology, Virus, Influenza B)\tN-acetylaspartate and N-acetyl-aspartylglutamate Measurement (Protein or Enzyme Type Measurement)\tGanda language (World languages)\tInfection Associated Congenital Nephrotic Syndrome (Nephrosis, congenital)", + "output": "Infection Associated Congenital Nephrotic Syndrome (Nephrosis, congenital)" + }, + { + "input": "Definition: Expectorants described as the concrete oleoresin obtained from PINACEAE such as longleaf pine (Pinus palustris). It contains a volatile oil, to which its properties are due, and to which form it is generally used. Turpentine is used as a solvent and an experimental irritant in biomedical research.\nConcepts: FAC01632 (Intellectual Product)\tTURPENTINE SPIRITS (Resins, Plant)\tOcular Sebaceous Carcinoma (carcinoma of eye)\tAbducens nerve disorder (Finding)\t17: 59437839-59433688 (Spatial Concept)", + "output": "TURPENTINE SPIRITS (Resins, Plant)" + }, + { + "input": "Definition: cellular response to vitamin described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a folic acid stimulus.\nConcepts: response to vitamin B9 (response to folic acid)\tGrade 4 Methemoglobinemia (Methemoglobinemia, CTCAE)\tHPV-58 (Virus)\tDandruff brand (Pharmacologic Substance)\tAffiliated (General Qualifier)", + "output": "response to vitamin B9 (response to folic acid)" + }, + { + "input": "Definition: Conjunctival Diseases described as a disorder of the vasculature of the cornea.\nConcepts: PROS0103 (Intellectual Product)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Problem Because of Barriers in World (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tConjunctival vascular disorder (Ocular vascular disorders NEC)\tdibromodulcitol (Organic Chemical)\tTRIPTORELIN PAMOATE (Gonad regulating hormone agent)", + "output": "Conjunctival vascular disorder (Ocular vascular disorders NEC)" + }, + { + "input": "Definition: benzamide described as an orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.\nConcepts: Tribbles Pseudokinase 1 wt Allele (TRIB1 gene)\tADL01-Clear Dishes Usual Performance (ADCS-ADL Questionnaire Question)\tDRRI1E05 (Intellectual Product)\tSpontaneous rupture of the globe (Disease or Syndrome)\tEnzalutamida (E [Preparations])", + "output": "Enzalutamida (E [Preparations])" + }, + { + "input": "Definition: Hyperbilirubinemia, Hereditary described as an inherited autosomal recessive disorder characterized by the presence of mild jaundice due to abnormalities in the bilirubin transportation from the liver parenchyma to the biliary system.\nConcepts: EMO1-Number Stimuli Portraying Disgust (Intellectual Product)\tRP-HPLC (Chromatography, Affinity)\tPAQR1 (Gene or Genome)\tTrimethoprim Sulfate (Pharmacologic Substance)\tHYPERBILIRUBINEMIA, DUBIN-JOHNSON TYPE (Inherited disorder of bilirubin metabolism)", + "output": "HYPERBILIRUBINEMIA, DUBIN-JOHNSON TYPE (Inherited disorder of bilirubin metabolism)" + }, + { + "input": "Definition: Finding described as a response that the left lymph node dissection was not done.\nConcepts: FAC062-I Worry About Dying (FACT-BRM Version 4 Questionnaire Question)\tResident tissue macrophage (Mononuclear cell)\tRight Lymph Node Dissection not Done (CPTAC Responses)\tandrostene (Organic Chemical)\tProduct containing tazobactam (Organic Chemical)", + "output": "Right Lymph Node Dissection not Done (CPTAC Responses)" + }, + { + "input": "Definition: Duodenum and Ampulla of Vater Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 described as duodenum and ampulla of Vater neuroendocrine tumor in which the primary tumor cannot be assessed.\nConcepts: Glutathione Peroxidase 3 wt Allele (Gene or Genome)\tETHNIC (racial and ethnic origin)\tPrecursor B-Lymphoblastic Lymphoma Stage III (B Lymphoblastic Lymphoma)\tLung Injury, Acute (Pulmonary Edema)\tDuodenum and Ampulla of Vater Neuroendocrine Tumor pTX TNM Finding v8 (Duodenum and Ampulla of Vater Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8)", + "output": "Duodenum and Ampulla of Vater Neuroendocrine Tumor pTX TNM Finding v8 (Duodenum and Ampulla of Vater Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: something described as human MAS1 wild-type allele is located within 6q25.3-q26 and is approximately 1 kb in length. This allele, which encodes proto-oncogene Mas protein is involved in growth regulation.\nConcepts: MAPK activation (Molecular Function)\tBILIARY OBSTRUCTION (Biliary Tract Diseases)\tDelayed Release Particle Tablet Dose Form (Biomedical or Dental Material)\tJejunum and Ileum Neuroendocrine Tumor Pathologic Distant Metastasis TNM Finding v8 (Jejunum and Ileum Neuroendocrine Tumor Pathologic TNM Finding v8)\tMGRA (MAS1 gene)", + "output": "MGRA (MAS1 gene)" + }, + { + "input": "Definition: regulation of translation in response to endoplasmic reticulum stress described as any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.\nConcepts: By mouth (Drug Administration Routes)\tStage IIIA (Classification)\tpositive regulation of translation in response to ER stress (regulation of translation in response to endoplasmic reticulum stress)\tintegrin alphav-beta5 complex (integrin complex)\tAlphacoronavirus-1 (Genus Alphacoronavirus)", + "output": "positive regulation of translation in response to ER stress (regulation of translation in response to endoplasmic reticulum stress)" + }, + { + "input": "Definition: Molecular Function described as the oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain.\nConcepts: Xanthotoxine (DNA Crosslinking Agent)\tregulation of cell adhesion involved in growth plate cartilage morphogenesis (Cell Function)\tAmsler chart assessment (Ophthalmic examination and evaluation)\tpeptide cross-linking via L-cystine (peptide cross-linking)\tERG Deregulation (Cell or Molecular Dysfunction)", + "output": "peptide cross-linking via L-cystine (peptide cross-linking)" + }, + { + "input": "Definition: Pharmacologic Substance described as an alkaloid drug belonging to a class of anticancer agents called topoisomerase inhibitors.\nConcepts: radiation carcinogenesis (Neoplastic Process)\t9-nitro-CPT (Pharmacologic Substance)\tSecretin measurement (Gastrointestinal hormone measurement)\tElectronic Supplementary Material (Intellectual Product)\tMIRN433 (Gene or Genome)", + "output": "9-nitro-CPT (Pharmacologic Substance)" + }, + { + "input": "Definition: Toy Breed described as a compact, stocky toy dog with a long, straight-flowing coat that has profuse feathering and may be any color. It has a broad head with large, slightly prominent eyes, and drooping heart-shaped, long feathering ears. The average height range is 6-9 inches and the average weight range is 8-10 pounds.\nConcepts: Million Organisms per Milligram (Unit of Arbitrary Substance Concentration)\tobstruction; gastric outlet (Stomach Diseases)\tBig Endothelin-1 (Amino Acid, Peptide, or Protein)\tGastric Irrigation/Lavage Procedure Kit/Trays (Procedure Kit/Trays, Irrigation/Lavage)\tPekingese dog (Dog family)", + "output": "Pekingese dog (Dog family)" + }, + { + "input": "Definition: RESPIRATORY FUNCTIONS: GENERAL TERMS described as the process of exchange of gases and removal of the end products of metabolism\nConcepts: LYMPHOSARCOMA, MALIGNANT (Experimental Organism Neoplasm)\tcommittee for the protection of human subjects (Professional or Occupational Group)\tRespiratory function (Inspiration function)\tCONTROL, HEMATOCRIT (Indicator, Reagent, or Diagnostic Aid)\tCavitas oris, NOS (Gastrointestinal tract structure)", + "output": "Respiratory function (Inspiration function)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Self-administered (WHODAS 2.0 36-item Version Self-administered) Overall, in the past 30 days, how many days were these difficulties present?\nConcepts: MT MMP Enzymes (Amino Acid, Peptide, or Protein)\tWD7H1 (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)\tLiter per Microgram per Meter Squared (Unit of Dose Calculation)\tHand Navicular Bone (Bone structure of proximal carpus)\tDiscectomy Curettes (Medical Device)", + "output": "WD7H1 (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: something described as moderate symptoms; oral intervention indicated\nConcepts: Anhydrides, Phthalic (Organic Chemical)\tGrade 2 Lung Infection, CTCAE (Finding)\tDermatitis due to unspecified substance taken internally (Noninfectious, vesicular AND/OR bullous disease)\tCIR (Ion Channel Protein Gene)\tRenal medullary interstitial inflammation (Pathologic Function)", + "output": "Grade 2 Lung Infection, CTCAE (Finding)" + }, + { + "input": "Definition: Medical Device described as a dental hand instrument is a hand-held device intended to perform various tasks in general dentistry and oral surgery procedures. The device includes the operative burnisher, operative amalgam carrier, operative dental amalgam carver, surgical bone chisel, operative amalgam and foil condenser, endodontic curette, operative curette, periodontic curette, surgical curette, dental surgical elevator, operative dental excavator, operative explorer surgical bone file, operative margin finishing file, periodontic file, periodontic probe, surgical rongeur forceps, surgical tooth extractor forceps, surgical hemostat, periodontic hoe, operative matrix contouring instrument, operative cutting instrument, operative margin finishing periodontic knife, periodontic marker, operative pliers, endodontic root canal plugger, endodontic root canal preparer, surgical biopsy punch, endodontic pulp canal reamer, crown remover, periodontic scaler, collar and crown scissors, endodontic pulp canal filling material spreader, surgical osteotome chisel, endodontic broach, dental wax carver, endodontic pulp canal file, hand instrument for calculus removal, dental depth gauge instrument, plastic dental filling instrument, dental instrument handle, surgical tissue scissors, mouth mirror, orthodontic band driver, orthodontic band pusher, orthodontic band setter, orthodontic bracket aligner, orthodontic pliers, orthodontic ligature tucking instrument, forceps, for articulation paper, forceps for dental dressing, dental matrix band, matrix retainer, dental retractor, dental retractor accessories, periodontic or endodontic irrigating syringe, and restorative or impression material syringe.\nConcepts: Sacral Nerve Stimulator (Medical Device)\tleukonychia totalis was seen (Congenital leukonychia)\tINSTRUMENT, CUTTING, OPERATIVE (Medical Device)\tHemoglobin Subunit Beta (Carrier Proteins)\tmin.umol/l/m2 (Quantitative Concept)", + "output": "INSTRUMENT, CUTTING, OPERATIVE (Medical Device)" + }, + { + "input": "Definition: facit collagen location described as a collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils.\nConcepts: Service Item (product)\tN-acetylprocainamide (Pharmacologic Substance)\tPartial duplication of the bones of the ring finger (Duplication of phalanx of 4th finger)\tcollagen type XVI trimer (Fibril-Associated Collagens)\tSTF1 (Stefin Family Gene)", + "output": "collagen type XVI trimer (Fibril-Associated Collagens)" + }, + { + "input": "Definition: something described as the determination of the amount of antithrombin activity in a sample.\nConcepts: ANTHRMA (anticoagulant assays)\tGated Protein Transport (Cell Function)\tAutologous Anti-CD19CAR-HER2t/CD22CAR-EGFRt-expressing T-cells (Antineoplastic Immune Cell)\ttype IV protein secretion system (secretion by the type IV secretion system)\tHomograft, Syngeneic (Allograft surgical material)", + "output": "ANTHRMA (anticoagulant assays)" + }, + { + "input": "Definition: Quantitative Concept described as a derived unit of viable cell concentration defined as the number of billion colony forming units (10E9 CFU) in one gram of substance.\nConcepts: Distress Thermometer (Visual Analog Scale)\thistone H2A ubiquitination (Molecular Function)\ttriazoles (Azoles)\tStage IIA Bone Cancer AJCC v8 (Stage II Bone Cancer AJCC v8)\tbillion colony forming units/gram (Quantitative Concept)", + "output": "billion colony forming units/gram (Quantitative Concept)" + }, + { + "input": "Definition: phospholipase inhibitor activity described as stops, prevents or reduces the activity of a phospholipase D, an enzyme that catalyzes the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.\nConcepts: Seoul (Geographic Area)\tFacial Nerve Palsy Related to Birth (Disease or Syndrome)\tphospholipase D inhibitor activity (Molecular Function)\tpolycythemia stress (Disease or Syndrome)\tD-galactonate transmembrane transport (Molecular Function)", + "output": "phospholipase D inhibitor activity (Molecular Function)" + }, + { + "input": "Definition: something described as a response indicating that a person's primary treatment goal is to reduce suffering.\nConcepts: 73 URETERS (Body Part, Organ, or Organ Component)\tPrimary Goal to Lessen Suffering (Intellectual Product)\tStructure of triangular ligament (Peritoneum)\tVaccinia Vaccine (Immunologic Factor)\tAudio Visual Aids (Teaching Materials)", + "output": "Primary Goal to Lessen Suffering (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a GLYCOINOSITOL PHOSPHOLIPID MEMBRANE ANCHOR-containing ephrin with a high affinity for the EPHA3 RECEPTOR. Early in embryogenesis it is expressed at high levels in the MESENCEPHALON; SOMITES; branchial arches, and LIMB BUDS.\nConcepts: iodine 131-6-beta-iodomethyl-19-norcholesterol (Organic Chemical)\tLERK 6 Protein (Biologically Active Substance)\tshwachman-diamond syndrome (Osteochondrodysplasias)\taromatherapy massage (Aromatherapy)\tMARK (Gene or Genome)", + "output": "LERK 6 Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate.\nConcepts: PpGpp-3'-pyrophosphohydrolase activity (diphosphoric monoester hydrolase activity)\tUnresected (Disease Treatment Qualifier)\tHereditary sensory and autonomic neuropathy type VII (Rare Non-Neoplastic Disorder)\tfluoride transmembrane transport (Cell Function)\tThymic Germ Cell Tumor T2b TNM Finding (Mediastinal Germ Cell Tumor T2 TNM Finding)", + "output": "PpGpp-3'-pyrophosphohydrolase activity (diphosphoric monoester hydrolase activity)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of blood microparticle formation.\nConcepts: arginine anabolism via ornithine (Molecular Function)\tMIR122 Pre-miRNA (pre-miRNA)\tExfoliative Syndrome (Anterior chamber structural change, deposit and degeneration)\tsalicin transport (Cell Function)\tpositive regulation of microparticle generation (regulation of blood microparticle formation)", + "output": "positive regulation of microparticle generation (regulation of blood microparticle formation)" + }, + { + "input": "Definition: Hereditary retinal dystrophy described as an autosomal recessive familial disorder that usually presents in childhood with POLYNEUROPATHY; SENSORINEURAL HEARING LOSS; ICHTHYOSIS; ATAXIA; RETINITIS PIGMENTOSA; and CARDIOMYOPATHIES. (From Joynt, Clinical Neurology, 1991, Ch37, p58-9; Rev Med Interne 1996;17(5):391-8) This condition can be caused by mutation in the genes encoding peroxisomal phytanoyl-CoA hydroxylase or proteins associated peroxisomal membrane, leading to impaired catabolism of PHYTANIC ACID in PEROXISOMES.\nConcepts: Cistaceae (Magnoliopsida)\tHereditary Motor And Sensory Neuropathy IV (Disorder of fatty acid metabolism)\tanthranilate synthase complex (Cell Component)\tRight Tubo-Ovarian (Anatomy Qualifier)\tNuclear Division Alteration (regulation of organelle organization)", + "output": "Hereditary Motor And Sensory Neuropathy IV (Disorder of fatty acid metabolism)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Proxy-administered (WHODAS 2.0 36-item Version Proxy-administered) In the past 30 days, how much difficulty did your relative have in: Moving around inside their home?\nConcepts: Asymmetry of nostrils (Abnormality of the nares)\tAnalyzers, Point-of-Care, Whole Blood, Gas/pH/Electrolyte/Metabolite (Medical Device)\tIL-15R (Molecular Function)\tCyanophora (Algae)\tWD6D2 3 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", + "output": "WD6D2 3 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormal amount of hair.\nConcepts: FT-PUL 2.0 TESTCD (CDISC Functional Test Terminology)\tCutaneous Mastocytoses (Hematologic neoplasm of uncertain behavior)\tAJCC v7 - Anatomic Stage (Intellectual Product)\tC6 Zinc Cluster (Zinc Fingers)\tAbnormality of hair density (Abnormal hair morphology)", + "output": "Abnormality of hair density (Abnormal hair morphology)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+).\nConcepts: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity (methyltransferase activity)\tNephrogenic metaplasia (Glandular metaplasia)\tnifedipine oxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tMetastatic Non-Cutaneous Melanoma (Metastatic melanoma)\t1-16:0-2-18:2-digalactosyldiacylglycerol desaturase activity (Molecular Function)", + "output": "nifedipine oxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: something described as a cyclin subtype that is specific for CYCLIN-DEPENDENT KINASE 4 and CYCLIN-DEPENDENT KINASE 6. Unlike most cyclins, cyclin D expression is not cyclical, but rather it is expressed in response to proliferative signals. Cyclin D may therefore play a role in cellular responses to mitogenic signals.\nConcepts: Tentatively Approved (Approved)\tIVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Cortical, Lissencephaly (Medical Device)\tCyclin-D (Protein Family)\tRegimen Used to Treat Sarcoma (Chemo/immuno/hormone Therapy Regimen)\tEPM (STX2 gene)", + "output": "Cyclin-D (Protein Family)" + }, + { + "input": "Definition: Muscular Dystrophy described as an X-linked genetic disorder caused by a mutation in the dystrophin gene characterized by early onset, rapidly progressive skeletal muscle weakness and atrophy initially involving the lower extremities that eventually affect the entire body including respiratory and cardiac muscles.\nConcepts: Metastatic Tumor Site Indicator (Finding)\tdystrophy; muscular, Duchenne type (Disease or Syndrome)\tpositive regulation of CD4-positive, alpha-beta T cell proliferation (positive regulation of CD4-positive, alpha-beta T cell activation)\thot weather (Natural Phenomenon or Process)\tDyes (Indicator, Reagent, or Diagnostic Aid)", + "output": "dystrophy; muscular, Duchenne type (Disease or Syndrome)" + }, + { + "input": "Definition: Laryngeal stent described as stents designed for deployment into the larynx to prevent opposing mucosal surfaces from touching, instead of providing 360 degrees of support as most stents do. These stents typically consist of a silicone (either clear or radiopaque) tube often with a wide T configuration, but some other keels resemble an umbrella; the stents are available in several sizes. Keel stents are mainly intended to prevent the laryngeal web from reforming; they are frequently used in children with congenital laryngeal web or laryngeal stenosis (i.e., atresia), to repair anterior glottis stenosis, and to prevent stenosis after hemilaryngectomy.\nConcepts: Phenyl acetate (Pharmacologic Substance)\tLaryngeal keel (Implants)\tregulation of muscle contraction (Organ or Tissue Function)\tStage D1 (Intellectual Product)\tJOINT (Skeletal bone)", + "output": "Laryngeal keel (Implants)" + }, + { + "input": "Definition: Medical Device described as a gastroenterology-urology biopsy instrument is a device used to remove, by cutting or aspiration, a specimen of tissue for microscopic examination. This generic type of device includes the biopsy punch, gastrointestinal mechanical biopsy instrument, suction biopsy instrument, gastro-urology biopsy needle and needle set, and nonelectric biopsy forceps. This section does not apply to biopsy instruments that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.\nConcepts: myelin formation in central nervous system (myelin assembly)\taldose 1-epimerase activity (Molecular Function)\tINSTRUMENT, BIOPSY, MECHANICAL, GASTROINTESTINAL (Medical Device)\tFAC006-I Get Support From My Friends (FACT-BL Version 4 Questionnaire Question)\tEndothelium, Lymphatic (Tissue)", + "output": "INSTRUMENT, BIOPSY, MECHANICAL, GASTROINTESTINAL (Medical Device)" + }, + { + "input": "Definition: Biologically Active Substance described as multidrug resistance-associated protein 5 (1437 aa, ~161 kDa) is encoded by the human ABCC5 gene. This protein plays a role in the export of cyclic nucleotides.\nConcepts: pABC11 (Biologically Active Substance)\tSample Expt Docn (Intellectual Product)\tM-CSF production (cytokine production)\tMicrocephaly deafness syndrome (Hereditary disorder of nervous system)\tcellular response to cortisone stimulus (response to cortisone)", + "output": "pABC11 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as GTP-binding nuclear protein Ran (216 aa, ~24 kDa) is encoded by the human RAN gene. This protein is involved in nucleocytoplasmic transport of proteins and RNAs.\nConcepts: J591 monoclonal antibody (Pharmacologic Substance)\tUpper eyelid edema (Edema of eyelid)\tMR (Africa, Western)\tGTP-Binding Nuclear Protein Ran (Amino Acid, Peptide, or Protein)\tDifferentiated Thyroid Gland Carcinoma Under 45 Years AJCC v7 Stage (Neoplastic Process)", + "output": "GTP-Binding Nuclear Protein Ran (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: examination of eyelids described as delayed descent of the upper eyelid on downgaze. Also described by some authors as von Graefe sign.\nConcepts: tannase activity (Molecular Function)\tVaginal Mixed Epithelial and Mesenchymal Tumor (Mixed Neoplasm)\tneuromuscular transmissions (Organ or Tissue Function)\tLid lag (Abnormal eyelid movement)\tNPI1-Burden to Family (NPI Questionnaire Question)", + "output": "Lid lag (Abnormal eyelid movement)" + }, + { + "input": "Definition: something described as a natural analogue of actinomycin, a chromopeptide antineoplastic antibiotic isolated from the bacterial genus Streptomyces. Actinomycin C3 inhibits DNA replication as well as RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA and interfering with the function of topoisomerase II.\nConcepts: Bruton Tyrosine Kinase Measurement (Protein or Enzyme Type Measurement)\t2A-D-alloisoleucine-2B-D-alloisoleucine actinomycino-D (Actinomycin)\tProblem (Finding with explicit context)\tProstate Cancer Therapeutic Area User Guide v1.0 (CDISC Therapeutic Area User Guide Name and Version)\tOsteopathia, NOS (Parathyroid Diseases)", + "output": "2A-D-alloisoleucine-2B-D-alloisoleucine actinomycino-D (Actinomycin)" + }, + { + "input": "Definition: Extracorporeal Circulation described as procedures involving non-continuous blood purification (e.g., dialysis, filtration or perfusion) via vascular access with settings for dialysate and blood flow rates and treatment duration settings hybrid between CRRT TECHNIQUE and IRRT TECHNIQUE.\nConcepts: Mcl1 Inhibitor (Antineoplastic Agents)\tFacial melanosis (Disorder of skin of head)\tHybrid RRTs (Therapeutic or Preventive Procedure)\tBRAF/EGFR Inhibitor BGB-283 (BRAF inhibitor)\tENDINSPR (Pulmonary function tests)", + "output": "Hybrid RRTs (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as representation of data as a chronological sequence of events. Each event occurs at an instant in time and marks a change of state in a system.\nConcepts: traditional Chinese medicine Hou Gu Mi Xi (Traditional Chinese Medicine Formulation)\tIVD Test Reagent/Kits, Clinical Chemistry, Protein, Glycated (IVD Test Reagent/Kits, Clinical Chemistry, Protein)\tSROBJ (Intellectual Product)\tDiscrete Modeling (Modeling)\tEAA Agents (Pharmacologic Substance)", + "output": "Discrete Modeling (Modeling)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Actinomadura pelletieri.\nConcepts: PQL0125 (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tMicrococcus pelletieri (Bacterium)\tazepine (Organic Chemical)\tPHQ0104 (Intellectual Product)\tLung Carcinoma Metastatic in the Bone (Carcinoma bone)", + "output": "Micrococcus pelletieri (Bacterium)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of L-dopa decarboxylase activity.\nConcepts: FAC05207 (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)\tMB07133 (pyrimidine analog)\tup regulation of L-dopa decarboxylase activity (Molecular Function)\tv-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog Positive (Positive Laboratory Test Result)\tLisinopril product (Medicinal product categorized by structure)", + "output": "up regulation of L-dopa decarboxylase activity (Molecular Function)" + }, + { + "input": "Definition: Potassium-sparing Diuretic [EPC] described as a pteridinetriamine compound that inhibits SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS.\nConcepts: TRIAMTERENE (Pteridines)\tnuclear envelope breakdown (nuclear envelope organization)\tmeso-tartrate dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tLCN2CREA (Urine protein test)\tmenth-2-enone hydratase activity (Molecular Function)", + "output": "TRIAMTERENE (Pteridines)" + }, + { + "input": "Definition: Mediastinal Germ Cell Tumor Primary Tumor TNM Finding described as mediastinal germ cell tumor with pleural or pericardial dissemination.\nConcepts: NEISSERIA GONORRHOEAE, PENICILLINASE POSITIVE (Bacterium)\tDistress Score 0 (Distress Score Visual Analogue Scale)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, KRT14 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tFAC01541 (Intellectual Product)\tMediastinal Germ Cell Tumor T4 TNM Finding (Finding)", + "output": "Mediastinal Germ Cell Tumor T4 TNM Finding (Finding)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of genetic imprinting.\nConcepts: Gastric folds set (Set of anatomical folds)\tregulation of genetic imprinting (Cell Function)\tfms Proto-Oncogene Protein (Amino Acid, Peptide, or Protein)\tFAMILY TROGLOTREMATIDAE (Order Plagiorchiida)\tBRCA1 Mutation Negative (Laboratory or Test Result)", + "output": "regulation of genetic imprinting (Cell Function)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3.\nConcepts: saquinivir (Antiretroviral/Anti HIV)\tLeiomyosarcoma (Neoplastic Process)\tmicromitophagy (Mitophagy)\tTPO Signaling Pathway (Cell Function)\theme A formation (heme a metabolic process)", + "output": "heme A formation (heme a metabolic process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as mineralocorticoid receptor (984 aa, ~107 kDa) is encoded by the human NR3C2 gene. This protein is involved in the modulation of mineralcorticoid and glucocorticoid-dependent gene transcription.\nConcepts: Nuclear Receptor Subfamily 3 Group C Member 2 (Receptor)\tMandibular laterognathia (Disorder of mandible)\tWnt Positive (Positive Laboratory Test Result)\tMobility of bone functions (Functions of the joints and bones)\tUropod (Cell appendage)", + "output": "Nuclear Receptor Subfamily 3 Group C Member 2 (Receptor)" + }, + { + "input": "Definition: something described as a composite superficial feature of the frontal lobe of the macaque. Located on the dorsolateral surface, it consists of the superior limb of the arcuate sulcus, the inferior ramus of the arcuate sulcus and the spur of the arcuate sulcus ( Krieg-1975; Walker-1940 ). \\r\\nThe adult human has no feature topologically equivalent to the arcuate sulcus of the macaque ( Matelli-2004 ). One finds a similar angular depression, however, in the fetal cortex of the 32-33 week human. There the vertical, inferior limb appears to become the inferior precentral sulcus. The depression located rostral to it in the 32-33 week human fetus, a location comparable to that of the principal sulcus, appears to become the inferior frontal sulcus instead ( Savel'ev-2005 ). And, based upon the organization of architectonic areas relative to sulcal features, the superior, horizontal component appears similar in location to the superior frontal sulcus and superior precentral sulcus.\\r\\n Equivalent structures are not found in the smooth cerebral cortex of the rat or mouse ( NeuroNames ).\nConcepts: UDPG:flavonoid-3-O-glucosyltransferase activity (Molecular Function)\tSulcus arcuata (Body Part, Organ, or Organ Component)\tStructured Product Labeling Equivalence Codes Terminology (Intellectual Product)\tPropedeutic, Medical (health care personnel education)\ttoll-like receptor-2 (Toll-like receptors)", + "output": "Sulcus arcuata (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a monoclonal antibody directed against a specific tumor-associated antigen (TAA).\nConcepts: Nucleus lateralis anuli aqueductus (Body Part, Organ, or Organ Component)\tfucose:hydrogen symporter activity (fucose transmembrane transporter activity)\tWoolen Fibers (Textiles)\tfrontal association areas (Brain Gray Matter)\tShared Anti-Idiotype-AB-S016 (Monoclonal Antibodies)", + "output": "Shared Anti-Idiotype-AB-S016 (Monoclonal Antibodies)" + }, + { + "input": "Definition: Transferase described as an enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.\nConcepts: Choline acetyltransferase (Acetyltransferase)\tChronic Hepatitis C Therapeutic Area User Guide v1.0 (Intellectual Product)\tchromosome 15q tetrasomy syndrome (Disease or Syndrome)\tMENTAL RETARDATION, X-LINKED 19 (Disease or Syndrome)\tBrooke Modified Medical Research Council Manual Muscle Test Score, Plantar Flexion (Score)", + "output": "Choline acetyltransferase (Acetyltransferase)" + }, + { + "input": "Definition: Adenocarcinoma described as a carcinoma arising from the sweat glands. Representative examples include tubular carcinoma, spiradenocarcinoma, eccrine carcinoma, hidradenocarcinoma, and apocrine carcinoma.\nConcepts: Poor impulse control (symptoms related to behavior)\tThenar abnormality (Abnormality of the musculature of the hand)\tabsolute risk (Statistical Technique)\tNurse simple new home-visit 10 minutes (Health Care Activity)\tCarcinoma of Sweat Gland (Adenocarcinoma)", + "output": "Carcinoma of Sweat Gland (Adenocarcinoma)" + }, + { + "input": "Definition: LABORATORY ABNORMALITIES described as a group of five inherited disorders caused by mutations in the AUH, DNAJC19, OPA3, and TAZ genes. The disorders are characterized by impairment in the function of mitochondria, resulting in the accumulation and excretion of 3-methylglutaconic acid, and the presence of 3-methylglutaric acid in the urine.\nConcepts: Acute cholangitis (Disease or Syndrome)\tTUM (Yao language - Bantu)\tanti-CD22 immunotoxin (Immunotoxins)\tState and Local Projects, Risk Assessment and Prevention (Classification)\t3-@METHYLGLUTACONIC ACIDURIA (organic acidemias)", + "output": "3-@METHYLGLUTACONIC ACIDURIA (organic acidemias)" + }, + { + "input": "Definition: something described as transcription factor SOX-18 (384 aa, ~41 kDa) is encoded by the human SOX18 gene. This protein plays a role in the modulation of transcription.\nConcepts: UPDRS - Motor Examination: Rigidity Neck (Intellectual Product)\tstudy report completion date (End date)\tCervical Spinal Cord Ependymal Tumor (Neoplastic Process)\tStenosis;urethral meatal (Urethral Stenosis)\tTranscription Factor SOX-18 (TRANSCRIPTION FACTOR)", + "output": "Transcription Factor SOX-18 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as quality Of Life Enjoyment And Satisfaction Questionnaire - During the past week how much of the time have you: Dealt with the course/class work without undue stress?\nConcepts: Place.name (Name)\tg/mL/(ug/m2) (Unit of concentration)\tAmbient Intelligence (User-Computer Interface)\tup-regulation of kinin cascade (regulation of kinin cascade)\tQLES1-Course/Class Work Without Stress (Q-LES-Q Questionnaire Question)", + "output": "QLES1-Course/Class Work Without Stress (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: something described as extended Glasgow Outcome Scale - What has been the extent of disruption or strain?\nConcepts: GOSE - Family and Friendships: Extent of Disruption or Strain (GOSE Questionnaire Question)\turea amidohydrolase (Helicobacter pylori)\tProstate Acinar Adenocarcinoma, Lymphoepithelioma-Like Variant (Neoplastic Process)\tTaxilin Alpha wt Allele (TXLNA gene)\tBlood Corpuscle, White (Structure of myelopoietic tissue)", + "output": "GOSE - Family and Friendships: Extent of Disruption or Strain (GOSE Questionnaire Question)" + }, + { + "input": "Definition: something described as movement of lipids through a biological system; can be across cell membranes and epithelial layers and also can occur within intracellular compartments and extracellular compartments.\nConcepts: Lipid Transport (Biological Transport)\tcyclic-GMP-AMP synthase activity (nucleotidyltransferase activity)\tSSX4B wt Allele (SSX4B gene)\twt gain asistnce ndvdlea.15m (Nutrition management)\tGorilla gorillas (Hominidae)", + "output": "Lipid Transport (Biological Transport)" + }, + { + "input": "Definition: Antibody by function described as antibody which interferes with the reactivity of the others by binding available epitopes of homologous specificity; or, univalent antibody that can coat antigen bearing cells but not agglutinate them.\nConcepts: Parasitology, Other (Biomedical Occupation or Discipline)\tNeutralizing Antibody (Antibodies)\tUrologists (Physicians; Physician/Osteopath)\tAntibodies, Heterophile (MISCELLANEOUS SPECIFIC ANTIBODIES)\tmodulation by virus of host process (Cell Function)", + "output": "Neutralizing Antibody (Antibodies)" + }, + { + "input": "Definition: Congenital abnormal shape of digit described as digits that appear disproportionately short compared to the hand/foot. The word brachydactyly is used here to describe a series distinct patterns of shortened digits (brachydactyly types A-E). This is the sense used here.\nConcepts: pT0 Carcinoma of the Breast v6 (Breast Cancer Pathologic Primary Tumor TNM Finding v7)\tGlandula suprarenalis (Adrenal Glands)\tbenign neoplasm of uterus (Uterine Diseases)\tPRISM, FRESNEL, OPHTHALMIC (Communication and information assistive device)\tbrachydactyly was noted (Short digit)", + "output": "brachydactyly was noted (Short digit)" + }, + { + "input": "Definition: Functional Concept described as the act of hindering or obstructing or impeding.\nConcepts: interfere (Action)\t(Potency Unit)\tCaveola (Plasma membrane)\tCYTOMEGALOVIRUS INFECT (Viral disease other/nos)\tRNA-Binding Motif Protein 4 (Amino Acid, Peptide, or Protein)", + "output": "interfere (Action)" + }, + { + "input": "Definition: Neoplastic Process described as the return of an original malignancy after a period of remission.\nConcepts: PARASITIC INFECTION INFECTIOUS (Disorders, General, Functional and NEC)\tRecurrent Primary Malignancy (Recurrent Malignant Neoplasm)\tFoamy myocardial transformation of infancy (Disease or Syndrome)\tnegative regulation of membrane permeability (regulation of membrane permeability)\tFAD pyrophosphatase activity (nucleotide pyrophosphatase activity)", + "output": "Recurrent Primary Malignancy (Recurrent Malignant Neoplasm)" + }, + { + "input": "Definition: MMSE Functional Test Question described as mini-Mental State Examination - Where are we now? What is the building (name or type)?\nConcepts: Relative Bioavailability (Quantitative Concept)\tDRRI1F06 (Intellectual Product)\tPenile Cancer Clinical TNM Finding v8 (Finding)\tMMS1-What Is the Building (Intellectual Product)\tProfessional (Occupation or Discipline)", + "output": "MMS1-What Is the Building (Intellectual Product)" + }, + { + "input": "Definition: something described as invasive cancer more extensive than stage I, usually involving local lymph nodes without spread to distant anatomic sites. The definition of stage IIA depends on the particular type of cancer that it refers to; for example, for breast cancer, stage IIA is defined as follows: (T0, N1, M0); (T1, N1, M0); (T2, N0, M0). T0: No evidence of primary tumor. T1: Tumor 20 mm or less in greatest dimension. T1 includes T1mi. T1mi: Tumor 1 mm or less in greatest dimension. T2: Tumor more than 20 mm but not more than 50 mm in greatest dimension. N1: Metastasis to movable ipsilateral level I, II axillary lymph node(s). N0: No regional lymph node metastasis. M0: No clinical or radiographic evidence of distant metastasis. M0 includes M0(i+); for bone cancer, stage IIA is defined as follows: T1, N0, M0, G3, G4. T1: Tumor 8 cm or less in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G3: Poorly differentiated. G4: Undifferentiated.\nConcepts: rnrx infertility care (Health Care Activity)\tHave Nausea at Least Half the Time (Clinical or Research Assessment Answer)\trhizobactin 1021 metabolic process (Molecular Function)\tNasal Cavity and Ethmoid Sinus Cancer pMX TNM Finding v6 (Nasal Cavity and Ethmoid Sinus Cancer Pathologic Distant Metastasis TNM Finding v6)\tStage 2A (Classification)", + "output": "Stage 2A (Classification)" + }, + { + "input": "Definition: Anthelmintics described as anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region.\nConcepts: Santonin (Sesquiterpenes, Eudesmane)\tsynaptophysin (Membrane Proteins)\tNonfunctional Endocrine Neoplasm (Neoplastic Process)\tAm as Healthy as Anybody (Intellectual Product)\tE6-Binding Protein (Biologically Active Substance)", + "output": "Santonin (Sesquiterpenes, Eudesmane)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 (FACT-COG Version 3) Comments From Others: Other people have told me I seemed to have trouble remembering information.\nConcepts: PRKCDBP (CAVIN3 gene)\tFAC07521 (Intellectual Product)\tHyperhidrosis (Skin and Subcutaneous Tissue Disorders, CTCAE)\tEmtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate (Emtricitabine- and tenofovir-containing product)\tCavernous hemangioma of liver (Benign neoplasm of blood vessel of abdomen)", + "output": "FAC07521 (Intellectual Product)" + }, + { + "input": "Definition: Soft tissue lesion described as abnormal calcification of the vasculature.\nConcepts: Vascular calcifications (Disease or Syndrome)\tFACT-C Version 4 - Satisfied Communication Illness (Intellectual Product)\tMicroalbumin 4+ (Finding)\t4-aminoantipyrine (Indicator, Reagent, or Diagnostic Aid)\tGrade 1 Lymphocele (Lymphocele, CTCAE)", + "output": "Vascular calcifications (Disease or Syndrome)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Baseline (C-SSRS Baseline) Most lethal actual attempt date.\nConcepts: castor equi/horse hoof (Pharmacologic Substance)\tPharmacodynamics (Pharmacology)\tCSS0122A (C-SSRS Baseline Questionnaire Question)\tPSA RNA-pulsed dendritic cell vaccine (Immunologic Factor)\tIDSC1-Early Morning Insomnia (Intellectual Product)", + "output": "CSS0122A (C-SSRS Baseline Questionnaire Question)" + }, + { + "input": "Definition: Genetic Function described as any mutation that appears in the gametes and which will therefore be transmitted to the progeny with some frequency.\nConcepts: Mutation, Germline (Mutation Abnormality)\tFallopian Tube Cancer (Primary malignant neoplasm of fallopian tube)\ttest interpretation (Finding)\tPG13/LNc8 Retroviral Transduced Cloned T-Cells (Genetically-engineered Immune Cell)\tLectins (Antibody type)", + "output": "Mutation, Germline (Mutation Abnormality)" + }, + { + "input": "Definition: Cell Function described as the period of the cell cycle when CELLS divide their nucleus and cytoplasm.\nConcepts: vinculin-related protein, human (Amino Acid, Peptide, or Protein)\tAcupuncture needle (Medical Device)\tPhase, Cell Division (Cell Cycle Phase)\tIsointense (General Qualifier)\tAPL with t(17;17)(q21;q21); STAT5B-RARA (Acute Myeloid Leukemia with a Variant RARA Translocation)", + "output": "Phase, Cell Division (Cell Cycle Phase)" + }, + { + "input": "Definition: something described as a genus of nematodes of the superfamily ASCARIDOIDEA. Its organisms are found in the stomachs of marine animals and birds. Human infection occurs by ingestion of raw fish that contain larvae.\nConcepts: Spinal Muscular Atrophy of Childhood (Disease or Syndrome)\tanisakis (Superfamily Heterocheiloidea)\tGrade 4 Premature delivery (Premature Delivery, CTCAE)\tHCS01-Mean HCS Score (Intellectual Product)\tregulation of nitrate assimilation (regulation of nitrogen cycle metabolic process)", + "output": "anisakis (Superfamily Heterocheiloidea)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the small nuclear ribonucleoprotein polypeptide N (SNRPN) gene, located at chromosome 15q11.2, which encodes the protein small nuclear ribonucleoprotein-associated protein N. Genetic variants at this locus have been associated with Prader-Willi syndrome and autistic disorder of childhood onset.\nConcepts: PASI - Trunk (T): Sum X Area (PASI Clinical Classification Question)\tStimulus Attenuation (Stimulus Parameters)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SNRPN (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tNortheastern Asian Ancestry (Population Group)\tCDISC Clinical Classification WHO Clinical Staging of HIV/AIDS for Children Test Code Terminology (CDISC Clinical Classification Terminology)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SNRPN (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Medical & Physical Treatment described as a surgical procedure on the heart.\nConcepts: Monoplegic Cerebral Palsy (Spastic cerebral palsy)\tSURG PROCEDURE HEART (Cardiac Surgery procedures)\tpositive regulation of macrophage chemotaxis (positive regulation of macrophage migration)\tSupraglottic Cancer pN2a TNM Finding (Supraglottic Cancer Pathologic Regional Lymph Nodes TNM Finding v6)\tMeasured oral intake of 100 percent fruit juice in 24 hours (Oral intake)", + "output": "SURG PROCEDURE HEART (Cardiac Surgery procedures)" + }, + { + "input": "Definition: EYES AND EYE APPENDAGES described as lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.\nConcepts: Substantia propria corneae (Connective tissue by site)\tHuman MHC Non-Restricted Cytotoxic T-Cell Line TALL-104 (Pharmacologic Substance)\tphosphorus (Pharmacologic Substance)\tGene therapies (Therapeutic procedures and supportive care NEC)\tI (gray spinal laminae)", + "output": "Substantia propria corneae (Connective tissue by site)" + }, + { + "input": "Definition: HMG Family Gene described as human HMGB Family Genes encode abundant DNA-binding and bending HMG-Box Family proteins (with structure, rather than sequence, specificity) that play an architectural role in nucleoprotein assembly. They have two homologous DNA-binding HMG-box domains connected by a short basic linker to an acidic C-terminus that differs in length. Tail length may be the dominant factor mediating property differences among HMGB proteins and determines DNA-binding properties of the HMG boxes. The tail is essential for DNA-binding.\nConcepts: pacemaker battery (Electrical battery)\treturnedToReprocessorDate (Date in time)\t2nd grade completed (Finding)\tCarditis (Disease or Syndrome)\tHigh Mobility Group B Gene Family (Gene or Genome)", + "output": "High Mobility Group B Gene Family (Gene or Genome)" + }, + { + "input": "Definition: Receptor Mediated Endocytosis described as a family of high molecular weight GTP phosphohydrolases that play a direct role in vesicle transport. They associate with microtubule bundles (MICROTUBULES) and are believed to produce mechanical force via a process linked to GTP hydrolysis. This enzyme was formerly listed as EC 3.6.1.50.\nConcepts: Study Day of Organ Measurements (Temporal Concept)\tC165907 (Immunoglobulin G measurement)\tExternal Defibrillators (Medical Device)\tDynamins (Receptor Mediated Endocytosis)\tBone Mineral Density (Diagnostic Procedure)", + "output": "Dynamins (Receptor Mediated Endocytosis)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.\nConcepts: negative regulation of type IV hypersensitivity (negative regulation of T cell mediated immunity)\tRelevant Communications (Document type)\tCostochondral pain (Finding)\tHyperphosphaturia (DISORDERS OF PHOSPHORUS AND CALCIUM METABOLISM)\tStay at Home Parent (Occupation or Discipline)", + "output": "negative regulation of type IV hypersensitivity (negative regulation of T cell mediated immunity)" + }, + { + "input": "Definition: axis specification described as polarization of the follicle cells of an insect ovary along the anterior/posterior axis.\nConcepts: anterior/posterior axis specification, follicular epithelium (axis specification)\thypovitaminosis d (Reduced bone mineral density)\tC1 esterase inhibitor defic (Vascular Diseases)\tpositive regulation by host of cytolysis of symbiont cells (Cell Function)\tCarotenes (Vitamins)", + "output": "anterior/posterior axis specification, follicular epithelium (axis specification)" + }, + { + "input": "Definition: Decorative product described as an inactive substance used to make a product bigger or easier to handle. For example, fillers are often used to make pills or capsules because the amount of active drug is too small to be handled conveniently.\nConcepts: plant cell papilla (cell projection)\t4NT catabolism (nitrotoluene catabolic process)\tFiller (Industrial Aid)\tmethylnaphthalene catabolic process (naphthalene-containing compound metabolic process)\tMycete (Fungus)", + "output": "Filler (Industrial Aid)" + }, + { + "input": "Definition: something described as stage III includes: (T4, N0-2, M0, B0-1); IIIA (T4, N0-2, M0, B0); IIIB (T4, N0-2, M0, B1). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. M0: No visceral organ involvement. B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2.\nConcepts: cephalomannine (Taxanes)\tLINAPRAZAN (Proton Pump Inhibitors)\tStage III Mycosis Fungoides and S\u00e9zary Syndrome (Neoplastic Process)\tCytochrome P450, Family 11, Subfamily B, Polypeptide 1 wt Allele (Gene or Genome)\tWound, Penetrating (Traumatic injury)", + "output": "Stage III Mycosis Fungoides and S\u00e9zary Syndrome (Neoplastic Process)" + }, + { + "input": "Definition: Finding described as number of times an individual falls\nConcepts: Falls occurrence (Finding)\t17q23 (Chromosome band)\tAbnormality of zygomaticus major muscle (Anatomical Abnormality)\tCTV (Irradiated volume)\tNASAL POLYPECTOMY (Nasal therapeutic procedures)", + "output": "Falls occurrence (Finding)" + }, + { + "input": "Definition: Cell described as human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.\nConcepts: IL-18BP protein, human (Biologically Active Substance)\tDistal 15q deletion syndrome (Deletion of part of chromosome 15)\tpolar body extrusion after meiotic divisions (meiotic cytokinesis)\tCeralasertib (ATR Inhibitor)\tht-29 cell (Epithelial Cells)", + "output": "ht-29 cell (Epithelial Cells)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a vitamin A test system is a device intended to measure vitamin A in serum or plasma. Measurements obtained by this device are used in the diagnosis and treatment of vitamin A deficiency conditions, including night blindness, or skin, eye, or intestinal disorders.\nConcepts: Fibroma of Ovary (Ovarian Tumor of the Thecoma/Fibroma Group)\tACID, TRIFLUOROACETIC, VITAMIN A, HEXANE EXTRACTION (Indicator, Reagent, or Diagnostic Aid)\treceiptDate (Temporal Concept)\tNeonatal Sinus Tachycardia (Finding)\tNASAL POLYPOSIS (Polyp of nasal cavity and/or nasal sinus)", + "output": "ACID, TRIFLUOROACETIC, VITAMIN A, HEXANE EXTRACTION (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Dermal and epidermal conditions NEC described as a group of connective tissue diseases in which skin hangs in loose pendulous folds. It is believed to be associated with decreased elastic tissue formation as well as an abnormality in elastin formation. Cutis laxa is usually a genetic disease, but acquired cases have been reported.\nConcepts: APOA5 (Protein or Enzyme Type Measurement)\tATP:nucleoside-phosphate phosphotransferase activity (Molecular Function)\tStructure of intralimbic gyrus (Limbic gyrus)\tGeneralised elastolysis (Skin, Human)\tCarts, Filing, Radiographic Film/Cassette (Medical Device)", + "output": "Generalised elastolysis (Skin, Human)" + }, + { + "input": "Definition: Cell Function described as any biochemical process that results in the specification, formation or maintenance of the physical structure of chromatin.\nConcepts: monographs (Publications)\tnegative regulation of signal transduction involved in conjugation with cellular fusion (negative regulation of reproductive process)\tDRRI1F01 (DRRI-2 Questionnaire Question)\t2',2'-difluorodeoxycytidine (Nucleoside Metabolic Inhibitor [EPC])\tChromatin Structural Process (Cell Function)", + "output": "Chromatin Structural Process (Cell Function)" + }, + { + "input": "Definition: Gene or Genome described as human NEDD8 wild-type allele is located in the vicinity of 14q12 and is approximately 15 kb in length. This allele, which encodes NEDD8 protein, is involved in the regulation of cell cycle progression, protein ubiquitination and protein catabolism.\nConcepts: Oral Fluorouracil-Uracil (tegafur)\tPanniculitis Ossificans (Non-Neoplastic Soft Tissue Disorder)\tPeptostreptococcus (living organism) (Clostridiales)\tNEDD-8 (NEDD8 gene)\tMultiple Known Primary Tumors Unknown at Initial Melanoma Diagnosis (CPTAC Responses)", + "output": "NEDD-8 (NEDD8 gene)" + }, + { + "input": "Definition: something described as the multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population.\nConcepts: CHROMATOGRAPHIC, CYSTINE (Medical Device)\tPancreatic Intraductal Papillary Mucinous Neoplasm, Pancreatobiliary-Type (Pancreatic Intraductal Papillary Mucinous Neoplasm)\tmedial ganglionic eminence cell proliferation (subpallium cell proliferation in forebrain)\tOrganizationIdentifier.identifier (Identifier)\tBrown Adipose Tissue Uncoupling Protein (Carrier Proteins)", + "output": "medial ganglionic eminence cell proliferation (subpallium cell proliferation in forebrain)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in both small GTPase activity and NMDA receptor signaling.\nConcepts: regulation of actin cable assembly (Cell Function)\tup regulation of production of molecular mediator of immune response (Physiologic Function)\tp250GAP (Signaling Pathway Gene)\tAppendix Neoplasm (Appendix mass)\tProblem;body image (Self-esteem disturbance)", + "output": "p250GAP (Signaling Pathway Gene)" + }, + { + "input": "Definition: Transport Protein Gene described as this gene plays a role in zinc transport.\nConcepts: Multichannel electrocardiograph (Medical Device)\tCurrent smoker (Smoking Status)\tSharps container (Medical Device)\tsolute carrier family 39 member 6 (Transport Protein Gene)\tnegative regulation of neutrophil chemotaxis (regulation of neutrophil chemotaxis)", + "output": "solute carrier family 39 member 6 (Transport Protein Gene)" + }, + { + "input": "Definition: Carts, Storage/Transport described as carts designed to store, display, and provide ready access to dressings and bandages. These carts usually include large wheels (e.g., 4 inch/10cm) and a closed stainless steel multiple drawer, shelf, or shelf/drawer cabinet-like structure; they may have hinged or sliding (either glass or metallic) doors. Most carts also include trays, a dressing/sponge bowl, and a pail for trash. Dressing/bandage carts may also include storage for handheld surgical instruments, drugs, and other supplies needed to perform dressing and/or bandaging.\nConcepts: Nerve agent GA (Organic Chemical)\tCarts, Storage/Transport, Dressing/Bandage (Carts, Storage/Transport)\tDRRI-2 - D: Witnessed Someone Unit Wounded (Intellectual Product)\tTrout, Rainbow (Salmonidae)\tOrganization Effective Date Range (Temporal Concept)", + "output": "Carts, Storage/Transport, Dressing/Bandage (Carts, Storage/Transport)" + }, + { + "input": "Definition: Terpenes described as fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24.\nConcepts: adult grade III lymphomatoid granulomatosis (Grade III Lymphomatoid Granulomatosis)\tAbnormality of hair texture (Abnormal hair morphology)\tNeoplasm of Anterior Tongue (Tongue Neoplasms)\tsesquiterpene (Organic Chemical)\tvital exhaustion; state (Finding)", + "output": "sesquiterpene (Organic Chemical)" + }, + { + "input": "Definition: Pharmacologic Substance described as the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression. Nortriptyline blocks the norepinephrine presynaptic receptors, thereby blocking the reuptake of this neurotransmitter and raising the concentration in the synaptic cleft in the CNS. Nortriptyline also binds to alpha-adrenergic, histaminergic and cholinergic receptors. Long-term treatment with nortriptyline produces a downregulation of adrenergic receptors due to the increased stimulation of these receptors.\nConcepts: nortriptyline HCl (Organic Chemical)\tG quartet binding (DNA Binding)\tLymphocyte, Cytotoxic T (T-Lymphocyte)\tThyroid Stimulating Hormone Secreting Adenoma of Pituitary Gland (Thyrotroph adenoma)\tTF2S (TCEA1 gene)", + "output": "nortriptyline HCl (Organic Chemical)" + }, + { + "input": "Definition: Lung diseases described as a chronic and progressive lung disorder characterized by the loss of elasticity of the bronchial tree and the air sacs, destruction of the air sacs wall, thickening of the bronchial wall, and mucous accumulation in the bronchial tree. The pathologic changes result in the disruption of the air flow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough, and chest tightness. The two main types of chronic obstructive pulmonary disease are chronic obstructive bronchitis and emphysema.\nConcepts: Chronic Obstructive Airway Disease (Lesion of bronchus)\tCan you get to places out of walking distance (Intellectual Product)\tHPV-Related Verrucous Carcinoma (Human Papillomavirus-Related Squamous Cell Carcinoma)\tIVD Panels, Human Genetics, Peripheral Neuropathy, Motor, Mutation (Medical Device)\tERT - Fear Responded as Anger (ERT Functional Test Question)", + "output": "Chronic Obstructive Airway Disease (Lesion of bronchus)" + }, + { + "input": "Definition: Biologically Active Substance described as spectrin beta chain, non-erythrocytic 1 (2364 aa, ~275 kDa) is encoded by the human SPTBN1 gene. This protein plays a role in both calcium-dependent intercellular transport and cell morphology.\nConcepts: Pacemaker Procedure (Equipment-related procedure)\tstriated muscle myosin thick filament assembly (myosin filament assembly)\tBeta-Spectrin II (Cytoskeletal Proteins)\tGrade 4 Anorectal infection (Anorectal Infection, CTCAE)\tClimbing 9 Steps (Intellectual Product)", + "output": "Beta-Spectrin II (Cytoskeletal Proteins)" + }, + { + "input": "Definition: Tributary of brachiocephalic vein described as a superficial vein that is located on the cerebellum and that drains the cerebellum.\nConcepts: FISH (Food)\tPSN (Nodule Consistency)\tsodium:galactoside symporter activity (solute:sodium symporter activity)\tAlprostadil product (alprostadil)\tSet of cerebellar veins (Tributary of brachiocephalic vein)", + "output": "Set of cerebellar veins (Tributary of brachiocephalic vein)" + }, + { + "input": "Definition: negative regulation of G1/S transition of mitotic cell cycle described as any process that stops, prevents, or reduces the frequency, rate or extent of G1/S transition of mitotic cell cycle by stopping, preventing, or reducing the frequency, rate or extent of transcription from an RNA polymerase II promoter.\nConcepts: MGC26389 (ID2 gene)\tROCK01TN (CDISC Functional Test Terminology)\tnegative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter (negative regulation of G1/S transition of mitotic cell cycle)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TYR (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\t5,7-dichloro-8-hydroxyquinaldine (Medicament patch test product)", + "output": "negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter (negative regulation of G1/S transition of mitotic cell cycle)" + }, + { + "input": "Definition: Nematodes described as a genus of parasitic nematode worms which infest the duodenum and stomach of domestic and wild herbivores, which ingest it with the grasses (POACEAE) they eat. Infestation of man is accidental.\nConcepts: tissue fixation (Laboratory Procedure)\talkylglycerophosphoethanolamine phosphodiesterase activity (Molecular Function)\tHemonchus (Trichostrongyloidea)\tEEN (SH3GL1 gene)\tcrooked neck-like 1 protein, human (Amino Acid, Peptide, or Protein)", + "output": "Hemonchus (Trichostrongyloidea)" + }, + { + "input": "Definition: Breast Carcinoma described as a carcinoma that arises from the breast and is not caused by inherited genetic mutations.\nConcepts: Sporadic Breast Cancer (Breast Carcinoma)\tMyocardial Infarction, Non-ST-Elevation (Disease or Syndrome)\tMolecular Genetic (genetics and heredity)\tGastric Cancer pT1 TNM Finding v7 (Finding)\ttesticular feminisation syndrome (Disorder of steroid metabolism)", + "output": "Sporadic Breast Cancer (Breast Carcinoma)" + }, + { + "input": "Definition: Spatial Concept described as of, or pertaining to, the area surrounding the ventricles of the brain.\nConcepts: PERIVENTRICULAR (Spatial Concept)\tHistone 1, H3d Gene (Gene or Genome)\tendocardial cushion to mesenchymal transition (Cell Function)\t1-Propanesulfonamide, N-(3-((5-(4-chlorophenyl)-1H-pyrrolo(2,3-b)pyridin-3-yl)carbonyl)-2,4-difluorophenyl)- (Protein kinase inhibitors, antineoplastic drugs)\tCannot Be With People Due to Appearance (Intellectual Product)", + "output": "PERIVENTRICULAR (Spatial Concept)" + }, + { + "input": "Definition: Intravascular occluding catheter described as occlusion vascular catheters designed to interrupt blood flow in a vessel (i.e., embolization of an artery or vein) permanently. These catheters occlude the vessels by introduction of occlusion devices, such as detachable balloons, thrombogenic coils, or embolization microspheres. Permanent occlusion catheters are used in the treatment of spinal, cerebral, abdominal, and peripheral vascular lesions (e.g., inferior vena cava occlusion); they are also used for embolization of the uterine arteries in treatments such as arteriovenous malformations, carcinomas, ectopic pregnancy, and fibroid tumors.\nConcepts: 961 FAMILY COLUMBIDAE (Bird)\tStudy Protocol Version Target Accrual Number Range (Quantitative Concept)\tPermanent Vascular Occlusion Catheters (Intravascular occluding catheter)\tGalactokinase (Carbohydrate metabolism disorder marker)\t4: 78884157-78890165 (Chromosome 4 Physical Location)", + "output": "Permanent Vascular Occlusion Catheters (Intravascular occluding catheter)" + }, + { + "input": "Definition: something described as for an NCI Thesaurus role this association specifies the role's domain kind.\nConcepts: Role Has Domain (Idea or Concept)\tHPV-Mediated (p16-Positive) Oropharyngeal Cancer TNM Finding v8 (Finding)\tescherichia coli o157 (Enterohemorrhagic Escherichia coli)\tMicrobiomes (Genome)\tTibio-fibular synostosis (Congenital Abnormality)", + "output": "Role Has Domain (Idea or Concept)" + }, + { + "input": "Definition: COXEN Sensitivity Scale described as a score of 12 on the COXEN Sensitivity Scale.\nConcepts: Polydactyly of hand (Upper Extremity Deformities, Congenital)\tCOXEN Score 12 (COXEN Sensitivity Scale)\tA. frontobasalis medialis (Anterior cerebral artery A2 segment)\tCancers, Infratentorial (Malignant neoplasm of brain)\tbHLHa3 (Biologically Active Substance)", + "output": "COXEN Score 12 (COXEN Sensitivity Scale)" + }, + { + "input": "Definition: something described as c-X-C motif chemokine 2 (107 aa, ~11 kDa) is encoded by the human CXCL2 gene. This protein is involved in the regulation of both chemotaxis and hematopoietic stem cell proliferation.\nConcepts: regulation of intracellular cholesterol transport (Cell Function)\tFOOT PRURITUS (Pruritus)\tregulation of L-tyrosine uptake (regulation of amino acid import across plasma membrane)\tGROB Protein (Immunologic Factor)\tpresynaptic endocytic zone membrane (Synaptic Membranes)", + "output": "GROB Protein (Immunologic Factor)" + }, + { + "input": "Definition: something described as the formula to calculate body surface area as described by John D. Current. It is mathematically defined as: BSA (m^2) = 1321 + 0.3433 x Weight\nConcepts: Elasticity (Mechanical Phenomena)\tScheduledActivity.statusDate (Status Date)\tERY974 (Amino Acid, Peptide, or Protein)\tLinear Regression Body Surface Area Formula for Infants and Children (Body Surface Area Formula)\tAmenorrhea primary (Primary physiologic amenorrhea)", + "output": "Linear Regression Body Surface Area Formula for Infants and Children (Body Surface Area Formula)" + }, + { + "input": "Definition: Relationships described as something regarded as a normative example.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Borrelia Species (Medical Device)\tTranscendental Meditation(TM) short course group each course (Hypnotherapy and/or meditation)\tClassic (Qualitative Concept)\tPostpartum Uterine Inversion (Uterine Prolapse)\tHave you had pain in your mouth (Intellectual Product)", + "output": "Classic (Qualitative Concept)" + }, + { + "input": "Definition: Basic Dosage Form Category described as a type of semi-solid pharmaceutical dose form that hardens after application to form a seal or bond.\nConcepts: Hematopoietic Cell Transplant Relapse Standard Risk Rate (Rate)\t8-Core Prostate Biopsy (Diagnostic Procedure)\tMurine coronavirus (Virus)\tCement (Biomedical or Dental Material)\tBrachytelephalangy (Finding)", + "output": "Cement (Biomedical or Dental Material)" + }, + { + "input": "Definition: developmental cell growth described as the process in which outgrowths develop from the shafts of existing axons.\nConcepts: proline:proton symporter activity (hydrogen:amino acid symporter activity)\tMetaphyseal chondrodysplasia (Skeletal dysplasia)\tcollateral sprouting (Cell Function)\tFlow Rates, Forced Expiratory (Pulmonary Ventilation)\tinterleukin 6 receptor (Receptor)", + "output": "collateral sprouting (Cell Function)" + }, + { + "input": "Definition: LILRB2 gene described as human LILRB2 wild-type allele is located in the vicinity of 19q13.4 and is approximately 7 kb in length. This allele, which encodes leukocyte immunoglobulin-like receptor subfamily B member 2 protein, plays a role in binding to class I MHC antigens and the regulation of T-cell responses.\nConcepts: L2-L3 INTERVERTEBRAL SPACE (Body Part, Organ, or Organ Component)\tStage I Sarcoma of the Soft Tissue (Soft Tissue Sarcoma by AJCC v7 Stage)\tUDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity (UDP-galactosyltransferase activity)\tLeukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 wt Allele (LILRB2 gene)\tpharmacogenetics (Pharmacology)", + "output": "Leukocyte Immunoglobulin-Like Receptor, Subfamily B (With TM and ITIM Domains), Member 2 wt Allele (LILRB2 gene)" + }, + { + "input": "Definition: Neoplastic Process described as a non-encapsulated, well defined pulmonary blastoma, composed of irregular tubular structures. It affects mostly middle-aged adults and it is rare in children. The prognosis is better compared to the biphasic pulmonary blastoma.\nConcepts: Promotional Material Type (DataType)\taspartate family amino acid formation (alpha-amino acid biosynthetic process)\tcalcium-independent cell-matrix adhesion (Cell Function)\tENTEROCOCCUS HIRAE (Enterococcus, group III)\tEpithelial Predominant Pulmonary Blastoma (Epithelial Neoplasm)", + "output": "Epithelial Predominant Pulmonary Blastoma (Epithelial Neoplasm)" + }, + { + "input": "Definition: something described as prepackaged collections of the devices and supplies (either custom or standard) needed for the insertion of a catheter whose tip will reach the central venous system. The catheters are usually inserted into a large vein in the neck (internal or external jugular vein), chest (subclavian vein), or groin (femoral vein). Items in these kits may include gauge needles, sterile gloves, appropriate intravenous (IV) catheters, alcohol swabs, gauze pads, IV bags with solution, and tubing. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Central intravenous catheterization procedure kits and trays are intended for use during a variety of procedures, including the administration of fluids (e.g., medication, parenteral feeding), to perform central venous pressure measurements, and/or for other blood tests. They are used in hospitals (e.g., intensive and emergency care) and other healthcare facilities.\nConcepts: Invasive encapsulated follicular variant of papillary thyroid carcinoma (Tumor contained within organ capsule)\tDRRI-2 - D: Encountered Land Mines (Intellectual Product)\tProcedure Kit/Trays, Catheterization, Intravenous, Central Vein (Medical Device)\tSoftware, Nuclear Medicine Study (Intellectual Product)\tSGRQ Past 3 Months Version - Everything Too Much Effort (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)", + "output": "Procedure Kit/Trays, Catheterization, Intravenous, Central Vein (Medical Device)" + }, + { + "input": "Definition: Salpingectomy described as complete removal of the fallopian tube(s).\nConcepts: Test, Neuropsychological (Psychological Tests)\tPerihilar Bile Duct Cancer pT3 TNM Finding v8 (Perihilar Bile Duct Cancer Pathologic Primary Tumor TNM Finding v8)\tComplete Salpingectomy (Therapeutic or Preventive Procedure)\tIL-9 (Gene or Genome)\tdialects (Language)", + "output": "Complete Salpingectomy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production.\nConcepts: positive regulation of Th2 cell cytokine production (positive regulation of T cell cytokine production)\tBorderline Ovarian Mucinous Tumor/Atypical Proliferative Ovarian Mucinous Tumor with Microinvasion (Ovarian mucinous tumor)\tcellular response to interleukin-3 (cellular response to cytokine stimulus)\tPerformedClinicalInterpretation.severityCode (Severity Code)\tMicrobiology Susceptibility Completion Status (Qualitative Concept)", + "output": "positive regulation of Th2 cell cytokine production (positive regulation of T cell cytokine production)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of histone antibodies in a biological specimen.\nConcepts: Histone antibody Assay (Autoimmunity analyses)\tA27 CORPUS CALLOSUM (CEREBRAL HEMISPHERES, CORPUS CALLOSUM AND RHINENCEPHALON)\tInserters, Contact Lens (Medical Device)\tDRUM (Package Type)\tIncreased level of hippuric acid in urine (Finding)", + "output": "Histone antibody Assay (Autoimmunity analyses)" + }, + { + "input": "Definition: Experience of self and time functions described as specific mental functions of the subjective experiences related to the length and passage of time.\nConcepts: Bladder Urachal Cancer (Neoplastic Process)\tSecondary Pulmonary Hypertension (Pulmonary Hypertension)\tExperience of time (Experience of self and time functions)\t2'-hydroxydihydrodaidzein:NADP(+) 2'-oxidoreductase activity (Molecular Function)\tSOAPR1-Suggested Drug or Alcohol Problem (Intellectual Product)", + "output": "Experience of time (Experience of self and time functions)" + }, + { + "input": "Definition: Squamous cell carcinoma, keratinizing described as a squamous cell carcinoma of the skin with a prominent clear cell component.\nConcepts: Weight gain assistance individual each 15 minutes (Nutritional Support)\tSodium Chloride/Sodium Gluconate/Sodium Acetate/Potassium Chloride/Magnesium Chloride Solution (Pharmacologic Substance)\tCYAMORPH (Crystal Growth Measurement)\tvirus tail, fiber (Cell Component)\tskin neoplasm carcinoma squamous cell clear cell (Malignant epithelial neoplasm of skin)", + "output": "skin neoplasm carcinoma squamous cell clear cell (Malignant epithelial neoplasm of skin)" + }, + { + "input": "Definition: Structure of lower female genitourinary tract described as the genital canal in the female, extending from the UTERUS to the VULVA.\nConcepts: Vaginal structure (Female genitalia)\tJELLY, LUBRICATING, FOR TRANSURETHRAL SURGICAL INSTRUMENT (Medical Device)\tregulation of mesenchymal stem cell apoptosis involved in mesonephric nephron morphogenesis (Biologic Function)\tHandoff Report (Information Management)\tPlatycodi grandifolii / jie geng (Plant)", + "output": "Vaginal structure (Female genitalia)" + }, + { + "input": "Definition: GAD-7 Version 2 Questionnaire Question described as generalized Anxiety Disorder - 7 Version 2 (GAD-7 Version 2) Feeling afraid as if something awful might happen.\nConcepts: Immune Presence (Other Finding)\topen to enrollment (Clinical Study Status)\tMicrotubule-Organizing Center (cellular anatomical entity)\tTan (Qualitative Concept)\tGAD-7 Version 2 - Feel Afraid If Something Awful Happen (Intellectual Product)", + "output": "GAD-7 Version 2 - Feel Afraid If Something Awful Happen (Intellectual Product)" + }, + { + "input": "Definition: something described as tissue derived from a cardiac outflow tract from which the valve structure is rendered nonfunctional, or a segment of cardiac conduit.\nConcepts: Human Cardiac Tissue Non-valved (Tissue)\tpolytene chromosome ectopic fiber (cellular anatomical entity)\tChildhood absence epilepsy (Generalized Nonconvulsive Seizure Disorder)\tKH Domain Containing, RNA Binding, Signal Transduction Associated 1 wt Allele (Gene or Genome)\tparoxysmal hemoglobinuria (Anemia, Hemolytic)", + "output": "Human Cardiac Tissue Non-valved (Tissue)" + }, + { + "input": "Definition: Pharmacologic Substance described as a natural or synthetic substance, such as a drug, vitamin, hormone, plant product or food supplement, that may reduce the risk of developing or recurrence of tumor formation. Chemopreventive agent may work at different stages and may inhibit the initiation, promotion, transformation, and/or progression of the malignant process.\nConcepts: NRARP wt Allele (Gene or Genome)\tChemopreventive Agent (Pharmacologic Substance)\t3-(3-(4-((METHYLAMINO)METHYL)PHENYL)-1,2-OXAZOL-5-YL)-5-(4-(PROPANE-2-SULFONYL)PHENYL)PYRAZIN-2-AMINE (ATR Inhibitor)\tregulation of eosinophil activation (regulation of leukocyte activation)\tzantac [brand name] (Organic Chemical)", + "output": "Chemopreventive Agent (Pharmacologic Substance)" + }, + { + "input": "Definition: Common nursing interventions II described as caring for a patient to alleviate his or her rectal injury(ies) and/or symptoms. Service is billed in 15-minute increments.\nConcepts: HASIGGAB (Laboratory Procedure)\tDevice Status Tags (Medical Device)\tnucleobase-containing compound catabolic process (heterocycle catabolic process)\tRvs161p-Rvs167p complex (Cell Component)\tRectal care each 15 minutes (Elimination Management)", + "output": "Rectal care each 15 minutes (Elimination Management)" + }, + { + "input": "Definition: Agenesis of permanent molar described as agenesis of either mandibular second permanent molar or maxillary second permanent molar.\nConcepts: ACETYLGALACTOSAMINYLTRANSFERASES N (N-Acetylhexosaminyltransferases)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media, Manual Test (IVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media)\t2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tLaryngeal Cancer pN2a TNM Finding v8 (Finding)\tAgenesis of second permanent molar (Congenital Abnormality)", + "output": "Agenesis of second permanent molar (Congenital Abnormality)" + }, + { + "input": "Definition: Benign tumor of skin with pilar differentiation described as a benign hair follicle neoplasm in the outer hair sheath and infundibulum, characterized by abrupt keratinization and central lumen with ghost cells.\nConcepts: cloaca septation (tube morphogenesis)\tBenign Pilomatrixoma (Neoplasm of skin with adnexal differentiation)\tPlatelet Threshold At Response (Intellectual Product)\tChemical Agent Protection Garments (Medical Device)\tsurfactant homeostasis (chemical homeostasis within a tissue)", + "output": "Benign Pilomatrixoma (Neoplasm of skin with adnexal differentiation)" + }, + { + "input": "Definition: Albinism, Ocular described as an X-linked inherited disorder caused by mutations in the GPR143 gene. It is characterized by reduced visual acuity and reduced stereoscopic vision. Other abnormalities include nystagmus, strabismus, and photophobia.\nConcepts: TLR3 wt Allele (TLR3 gene)\tcapsule poly-gamma-glutamate synthesis (poly-gamma-glutamate biosynthetic process)\tX-linked recess ocular albin (Genetic Diseases, X-Linked)\tashermans syndrome (Noninflammatory disorder of the female genital organs)\trhythmic synaptic transmission (Organ or Tissue Function)", + "output": "X-linked recess ocular albin (Genetic Diseases, X-Linked)" + }, + { + "input": "Definition: Surface of region of neck of scapula described as surface of region of neck of scapula bounding infraglenoid tubercle.\nConcepts: Inferior surface of neck of scapula (Surface of region of neck of scapula)\tGPRC5C (Amino Acid, Peptide, or Protein)\t8C-naringenin dibenzoylmethane tautomer glucosyltransferase activity (Molecular Function)\tnegative regulation of Rho-dependent protein serine/threonine kinase activity (negative regulation of protein serine/threonine kinase activity)\tcomplicated by (Behavior descriptors)", + "output": "Inferior surface of neck of scapula (Surface of region of neck of scapula)" + }, + { + "input": "Definition: Cell Function described as the process in which relatively unspecialized cells acquire specialized structural and/or functional features cells that make up the notochord. Differentiation includes the processes involved in commitment of a cell to a notochord cell fate.\nConcepts: monilial (Fungi)\tnotochord cell differentiation (Cell Function)\tAdenoviral Cancer Vaccine PF-06936308 (Pharmacologic Substance)\tContinuous Temperature Monitoring Device (Manufactured Object)\tThrombospondin 1 Measurement (Laboratory Procedure)", + "output": "notochord cell differentiation (Cell Function)" + }, + { + "input": "Definition: cellular anatomical entity described as non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode.\nConcepts: BPI1-Surgery in Past Month (BPI Questionnaire Question)\tlateral loop (Cell Component)\tGrowth Hormone Insensitivity Syndrome (Disease or Syndrome)\tIsolation Room Supply Carts (Carts, Storage/Transport)\tUnusual infection (Abnormality of immune system physiology)", + "output": "lateral loop (Cell Component)" + }, + { + "input": "Definition: Genitourinary symptoms described as excretion of urine; commonly denotes production of unusually large volumes of urine.\nConcepts: MATH domain binding (Molecular Function)\tRespiratory airway clearance (Organ or Tissue Function)\tdiureses (Urinary Tract Physiological Processes)\tLevel 2a Small for Gestational Age (GAIA Small for Gestational Age Level of Diagnostic Certainty)\tBrachycephalofrontonasal dysplasia (Hereditary Connective Tissue Disorder)", + "output": "diureses (Urinary Tract Physiological Processes)" + }, + { + "input": "Definition: Nucleotide Sequence described as the proximal (short) arm of chromosome Y.\nConcepts: Ligand Gated Ion Channel (Amino Acid, Peptide, or Protein)\tGamma rays (Natural Phenomenon or Process)\tADL03-Pastime: Reading (Intellectual Product)\tYp (Nucleotide Sequence)\tMLL/AF10 FUSION GENE (Gene or Genome)", + "output": "Yp (Nucleotide Sequence)" + }, + { + "input": "Definition: something described as a digital image obtained from a formalin-fixed, paraffin embedded CD20-positive B-cell specimen.\nConcepts: Radioimmunoassay Analyzers, Semiautomated (Medical Device)\tDigital Image-FFPE B-Cell (CD20) Slide (Intellectual Product)\tNucleus area H1 (Body Part, Organ, or Organ Component)\tUDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity (UDP-galactosyltransferase activity)\tOligometastatic Malignant Solid Neoplasm (Metastatic Malignant Solid Neoplasm)", + "output": "Digital Image-FFPE B-Cell (CD20) Slide (Intellectual Product)" + }, + { + "input": "Definition: Experimental Organism Neoplasm described as a malignant schwannoma of the heart of the heart arising from intramural swan cells that appears as a poorly circumscribed spindle cell mass within the ventricular myocardium with a more discrete boundary, that is generally more infiltrative than expansile.\nConcepts: Eye Dryness Affects Vision or Prevents Working (Intellectual Product)\tProductRelationship.typeCode (Intellectual Product)\tfetal process involved in parturition (Physiologic Function)\tSCHWANNOMA, INTRAMURAL, MALIGNANT (Neoplastic Process)\tCardiac troponin T increased (hematology: nonspecific abnormal findings)", + "output": "SCHWANNOMA, INTRAMURAL, MALIGNANT (Neoplastic Process)" + }, + { + "input": "Definition: Family health status described as capacity of a family to develop strategies for optimal functioning when a member has a chronic illness or disability\nConcepts: epigenetics (Science of genetics)\tLimb girdle muscular dystrophy due to gamma-sarcoglycan deficiency (Autosomal recessive muscular dystrophy with limb girdle distribution)\tFamily Normalization (Family Well-Being)\tCryptosporidial (Coccidia)\tRAD/ZD 1839 (Agent Combination Not Indexed in Open Clinical Trials)", + "output": "Family Normalization (Family Well-Being)" + }, + { + "input": "Definition: something described as a plasmid encoding the protein antiangiogenic metargidin plasmid (AMEP), the disintegrin domain of ADAM-15 (metargidin), with potential antiangiogenic and antimetastatic activities. Upon intratumoral electrotransfer of plasmid encoding AMEP, AMEP binds to cellular integrin receptors alpha-v-beta-3 (avb3) and alpha-5-beta-1 (a5b1), which are upregulated on activated endothelial cells and a variety of tumor cells. Binding to the integrin receptors may inhibit angiogenesis and may inhibit tumor cell proliferation.\nConcepts: Ledum latifolium (Plant)\tCan Taste Some Foods (Clinical or Research Assessment Answer)\tplasmid encoding antiangiogenic metargidin peptide (Angiogenesis Inhibitors)\tSevere dysplasia (DYSPLASIAS: GENERAL TERMS)\tTransport, Biologic (Cell Function)", + "output": "plasmid encoding antiangiogenic metargidin peptide (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as a coded value specifying the kind of application received and processed. EXAMPLE(S): Type 5 (Noncompeting Grant Progress Report)Type 1\nConcepts: FACT-L Version 4 - Have You Ever Smoked (FACT-L Version 4 Questionnaire Question)\tHypermobility of interphalangeal joints (Range of joint movement increased)\tGovernmentFunding.fundingTypeCode (Intellectual Product)\tMuscle attachment process (Organ or Tissue Function)\tLevel 3a Assessment of Prematurity and Gestational Age (Intellectual Product)", + "output": "GovernmentFunding.fundingTypeCode (Intellectual Product)" + }, + { + "input": "Definition: Gingival Overgrowth described as generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule.\nConcepts: Gingival Fibromatoses (Anatomical Abnormality)\tstage 0is transitional cell cancer of the renal pelvis and ureter (Carcinoma in Situ)\tMicrosomal Triglyceride Transfer Protein Deficiency (Retinal structural change, deposit and degeneration)\tEtOH (Nerve depressant drugs)\tSSTR2 Gene Product (G-Protein-Coupled Receptors)", + "output": "Gingival Fibromatoses (Anatomical Abnormality)" + }, + { + "input": "Definition: Ubiquitin-Transferase Gene described as this gene is involved in ubiquitination.\nConcepts: non-sensory hair (plasma membrane bounded cell projection)\tWW DOMAIN-CONTAINING PROTEIN 2 (Ubiquitin-Transferase Gene)\tNon-Neoplastic Internal Ear Disorder (Non-Neoplastic Ear Disorder)\tcomorbidity (Finding)\tNoncompaction of ventricular myocardium (Cardiomyopathies)", + "output": "WW DOMAIN-CONTAINING PROTEIN 2 (Ubiquitin-Transferase Gene)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum) to determine circulating antibodies directed toward the A2hnRNP core protein, known as anti-RA33 antibodies. Determination of anti-RA33 antibodies, combined with the determination of rheumatoid factor antibodies, may be used in the identification of patients at risk of erosive arthritis, especially those patients who suffer from systemic lupus erythematosus.\nConcepts: post-embryonic limb morphogenesis (post-embryonic appendage morphogenesis)\tThree tier interpretation model: Low risk (Finding)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism, Anti-RA33 Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism)\tbrugada syndrome (Cardiac Arrhythmia)\tADAM-Binding Protein Eve-1 (Amino Acid, Peptide, or Protein)", + "output": "IVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism, Anti-RA33 Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism)" + }, + { + "input": "Definition: Primary malignant neoplasm of trunk described as an adenocarcinoma of the breast arising from the lobules. This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal.\nConcepts: Malaria NOS (Parasitic Diseases)\tcarcinoma lobular (Adenocarcinoma)\tpVAXrcPSAv53l vaccine (Pharmacologic Substance)\tOrthodontic Appliance, Activator (Removable Orthodontic Appliances)\tGene Product, pol (Viral Replicase Complex Proteins)", + "output": "carcinoma lobular (Adenocarcinoma)" + }, + { + "input": "Definition: sulfurtransferase activity described as catalysis of the reaction: 2 S-adenosyl-L-methionine + a [2-oxoglutarate-dehydrogenase E2 protein] N6-octanoyl-L-lysine + 2 a sulfurated [sulfur carrier] = 2 L-methionine + 2 5'-deoxyadenosine + 2 H+ + a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine + 2 an unsulfurated [sulfur carrier].\nConcepts: Vascular Complications, Diabetic (Complications of Diabetes Mellitus)\tlipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein (Molecular Function)\tDeath-Like Domains (Amino Acid Sequence)\tmeal srvc ea.15min (Common nursing interventions)\tInferior and lateral ST segment elevation (Inferior ST segment elevation)", + "output": "lipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein (Molecular Function)" + }, + { + "input": "Definition: something described as the application of computer and information sciences to improve dental practice, research, education and management.\nConcepts: Score 0 (Finding)\tDental informatics (Biomedical Occupation or Discipline)\tguanine metabolism (Molecular Function)\tSYRINGOMYELIA/HYDROMYELIA (Syringomyelia)\tmetencephalon development (Organ or Tissue Function)", + "output": "Dental informatics (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: medications and vaccines described as drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction; they prevent acetylcholine from triggering muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, and in convulsive states.\nConcepts: TUBEROSE SCLEROSIS (Congenital hamartoma)\tNuclei metathalami (Cerebral nucleus)\tEnlarged antitragus (Abnormality of the antitragus)\tNEUROMUSCULAR BLOCK AGENTS (medications and vaccines)\tstructural constituent of presynapse (Molecular Function)", + "output": "NEUROMUSCULAR BLOCK AGENTS (medications and vaccines)" + }, + { + "input": "Definition: cellular protein modification process described as the addition of a tyrosine molecule to a protein amino acid.\nConcepts: protein tyrosinylation (Molecular Function)\tUDP-glucose:N-acylsphingosine D-glucosyltransferase activity (Molecular Function)\telectronic pacemaker (electronic stimulator)\tPolyglutamate Camptothecin (Organic Chemical)\tlateral part of the medial preoptic nucleus (Structure of medial preoptic nucleus)", + "output": "protein tyrosinylation (Molecular Function)" + }, + { + "input": "Definition: succinyl-CoA metabolic process described as the chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next, from other compounds, including glycine and succinyl-CoA.\nConcepts: Conjunctival hyperemia (Eye)\tSYSTEM, DIALYSATE DELIVERY, SEMI-AUTOMATIC, PERITONEAL (Medical Device)\tO-acetyl-ADP-ribose deacetylase activity (deacetylase activity)\tascrinvacumab (Monoclonal Antibodies)\ttetrapyrrole anabolism from glycine and succinyl-CoA (succinyl-CoA metabolic process)", + "output": "tetrapyrrole anabolism from glycine and succinyl-CoA (succinyl-CoA metabolic process)" + }, + { + "input": "Definition: something described as colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.\nConcepts: AerosolDrugForm (Dosage Form by Physical Form)\tAbnormal morphology of left ventricular trabeculae (Abnormal morphology of myocardial trabeculae)\tprotein-peroxisome targeting (peroxisomal transport)\tHomeodomain (Spatial Concept)\tactomyosin contractile ring, distal actin filament layer (cellular anatomical entity)", + "output": "AerosolDrugForm (Dosage Form by Physical Form)" + }, + { + "input": "Definition: DNA Sequence described as a sequence in DNA that can be recognized by a specific restriction enzyme.\nConcepts: Restriction Enzyme Recognition Site (Nucleotide Sequence)\tHypoinsulinemic hypoglycaemia and body hemihypertrophy (Digestive system hereditary disorder)\tCCQ02-Breathing Limit Social Activity (Intellectual Product)\tChiropractor - Nutrition (Professional or Occupational Group)\tregulation of DNA-dependent transcription in response to stress (regulation of transcription, DNA-templated)", + "output": "Restriction Enzyme Recognition Site (Nucleotide Sequence)" + }, + { + "input": "Definition: something described as catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate.\nConcepts: Anti-Adenovirus Serotype 5 Antibody (Adenovirus antibody)\tComplement C3a DesArg (Complement C3a measurement)\tCell Division Cycle Proteins (Regulatory Protein)\tammonia-lyase activity (carbon-nitrogen lyase activity)\thost peribacteroid membrane (Cell Component)", + "output": "ammonia-lyase activity (carbon-nitrogen lyase activity)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radioactive drug that is used for the diagnosis or treatment of disease. EXAMPLE(S): Technetium^99m DMSA Sodium fluoride F^18^ Fluorodeoxyglucose F^18^ OTHER NAME(S): Medicinal radiocompounds Radioactive tracer NOTE(S):\nConcepts: embryonal carcinoma of ovary (Malignant Ovarian Germ Cell Neoplasm)\tradioactive drug (Indicator, Reagent, or Diagnostic Aid)\tFLJ00029 (Gene or Genome)\tHematopoietin (Amino Acid, Peptide, or Protein)\tMyeloid Neoplasms with Germline GATA2 Mutation (Neoplastic Process)", + "output": "radioactive drug (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as an autosomal recessive disorder that is the most severe, neonatally lethal form of arthrogryposis a disorder characterised by congenital nonprogressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.\nConcepts: Multiple contracture syndrome, Finnish type (Inherited arthrogryposis)\tSubstance Use Ongoing (Event Occurrence Indicator)\tAlready mapped above AAHA ID #: 858 (Symptomatic disorders of the gastrointestinal tract)\tCOPPER REDUCTION, GLUCOSE (Indicator, Reagent, or Diagnostic Aid)\tLPS receptor activity (pattern recognition receptor activity)", + "output": "Multiple contracture syndrome, Finnish type (Inherited arthrogryposis)" + }, + { + "input": "Definition: Quantitative Concept described as hour times nanogram per milliliter, divided by milligram per gram.\nConcepts: Dia Interacting Protein Gene (Gene or Genome)\th.ng/ml/(mg/g) (Measurement Unit Description)\tzoology (biology)\trosiglitazone maleate (R [Preparations])\tMIR (Antisense RNA)", + "output": "h.ng/ml/(mg/g) (Measurement Unit Description)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of seed maturation.\nConcepts: Bone Marrow Donation (Operation on bone marrow)\tnegative regulation of seed maturation (negative regulation of post-embryonic development)\tpeptidyl-arginine deglycation (Molecular Function)\tdaphnetin 4-O-beta-glucosyltransferase activity (hexosyltransferase activity)\tInformation Systems, Data Management, Hospital, Asset/Maintenance (Manufactured Object)", + "output": "negative regulation of seed maturation (negative regulation of post-embryonic development)" + }, + { + "input": "Definition: something described as orally available, nanobubble-based, electrokinetically modified water (EMW) composed of reverse osmosis water where the minerals calcium chloride, magnesium chloride, and potassium bicarbonate have been added and with an increased oxygen concentration compared to normal water. Upon consumption, the EMW may have a beneficial effect on fatigue. This water may protect muscle cells against damage and may improve skeletal muscle function. The water is pretreated with strong, controlled turbulence to create charge-stabilized nanostructures.\nConcepts: OBNMFBT (Qualitative Concept)\tCLAUDIN-LIKE PROTEIN, 24-KD (Cell Adhesion Molecule Gene)\tTest Site Location (Geographic Area)\telectrokinetically modified water (Protective Agents)\tAdenoma of Oral Cavity (Neoplastic Process)", + "output": "electrokinetically modified water (Protective Agents)" + }, + { + "input": "Definition: Ligase described as e3 SUMO-protein ligase NSE2 (247 aa, ~28 kDa) is encoded by the human NSMCE2 gene. This protein plays a role in DNA double-strand break repair by homologous recombination, the prevention of DNA damage-induced apoptosis, and the sumolyation of protein substrates.\nConcepts: abuse physical (Domestic abuse)\tGrade 4 Bone Infection, CTCAE (Finding)\tNon-Structural Maintenance Of Chromosomes Element 2 Homolog (Amino Acid, Peptide, or Protein)\tubiquinone metabolism (oxidoreduction coenzyme metabolic process)\tLeukemic Cell (Neoplastic Hematopoietic and Lymphoid Cell)", + "output": "Non-Structural Maintenance Of Chromosomes Element 2 Homolog (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Enzyme described as abelson tyrosine-protein kinase 2 (1182 aa, ~128 kDa) is encoded by the human ABL2 gene. This protein plays a role in cell motility, apoptosis, cell adhesion, receptor endocytosis, autophagy, tyrosine phosphorylation and signal transduction.\nConcepts: regulation of fumigaclavine C formation (Molecular Function)\tclinical research and development (Research Activity)\tBSW (Bachelor's Degree)\tConcentrated Specimen (Biospecimen Condition)\tAbelson-Related Gene Protein (Protein Tyrosine Kinase)", + "output": "Abelson-Related Gene Protein (Protein Tyrosine Kinase)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a prognostic index for mantle cell lymphoma based on: age, performance status, lactate dehydrogenase (LDH), and leukocyte count. It differentiates patients into low-, intermediate-, and high-risk groups.\nConcepts: MCL International Prognostic Index (International Prognostic Index)\tPerfusion Pumps, Implantable (Medical Device)\tArea Under First Moment Curve (Area Under Curve)\tVFQ1-Difficulty Noticing Objects to Side (VFQ25-Interviewer Administered Format Questionnaire Question)\tIxazomib-Dexamethasone Regimen (Therapeutic or Preventive Procedure)", + "output": "MCL International Prognostic Index (International Prognostic Index)" + }, + { + "input": "Definition: something described as human SIAH2 wild-type allele is located in the vicinity of 3q25 and is approximately 22 kb in length. This allele, which encodes E3 ubiquitin-protein ligase SIAH2 protein, is involved in the mediation of ubiquitination. Expression of the gene may play a role in the development or progression of metastatic prostate neuroendocrine tumor.\nConcepts: Seven in Absentia Homolog 2 (Drosophila)wt Allele (Gene or Genome)\tGrade 3 Conjunctivitis infective (Conjunctivitis Infective, CTCAE)\tOximeters/Co-Oximeters (Measuring Instruments)\tOther (Form Directive)\tLeucine Crystal Measurement (Crystal Growth Measurement)", + "output": "Seven in Absentia Homolog 2 (Drosophila)wt Allele (Gene or Genome)" + }, + { + "input": "Definition: CDC25C gene described as human CDC25C wild-type allele is located in the vicinity of 5q31 and is approximately 53 kb in length. This allele, which encodes m-phase inducer phosphatase 3 protein, is involved in mitotic control and cell cycle progression.\nConcepts: Persistent open cranial sutures (Joint structure of suture of skull)\tCell Division Cycle 25 Homolog C wt Allele (CDC25C gene)\tRefractory Acute Lymphoblastic Leukemia (Childhood Acute Lymphoblastic Leukemia)\texit of virus from host cell nucleus (Cell Function)\tAphorisms and Proverbs as Topic (Intellectual Product)", + "output": "Cell Division Cycle 25 Homolog C wt Allele (CDC25C gene)" + }, + { + "input": "Definition: Cytological Techniques described as a technique used for the highly specific and selective capture and isolation of a cell population from a heterogeneous tissue section, cytological preparation, or live cell culture. This technique uses direct visualization of the cells via microscopy as well as a laser energy source for cutting and extraction of the cells.\nConcepts: -glucosamine 3-sulfotransferase 2 activity (heparan sulfate sulfotransferase activity)\tLaser Capture Microdissections (tissue/cell preparation)\tColour blindness, NOS (Abnormal retinal morphology)\tNLR Family Member X1 wt Allele (NLRX1 gene)\tMyelosuppressive Therapy (Therapeutic or Preventive Procedure)", + "output": "Laser Capture Microdissections (tissue/cell preparation)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as a synthetic 1-benzofuran and ethyl ester compound, and carbamate acetylcholinesterase inhibitor, that is used as a pesticide. It is characterized as a pale yellow viscous oily liquid, and exposure occurs by inhalation, ingestion, or contact.\nConcepts: negative regulation of adipocyte proliferation (regulation of fat cell proliferation)\tplacenta increta (Morbidly adherent placenta)\tVaginal Cancer Pathologic Distant Metastasis TNM Finding v7 (Vaginal Cancer Pathologic TNM Finding v7)\tcraniofacial dysmorphism-absent corpus callosum-iris colobomas-connective tissue dysplasia syndrome (Disease or Syndrome)\tbenfuracarb (Hazardous or Poisonous Substance)", + "output": "benfuracarb (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\nConcepts: Registration Specialist (Research Personnel)\tForensic Digital Data Copiers (Digital Data Copiers)\tI received high quality care from my regular doctor (Finding)\tregulation of fibroblast growth factor production (Cell Function)\tA4STR103 (4 Stair Ascend Functional Test Question)", + "output": "regulation of fibroblast growth factor production (Cell Function)" + }, + { + "input": "Definition: Motion Perception described as monocular distance cues for motion perception based on observer movements and the resultant movements of objects in the visual field.\nConcepts: Motion Parallax (Distance Perception)\tNM 006218.1:c.3139C>T (Cell or Molecular Dysfunction)\tLandolt Ring (Ophthalmic examination and evaluation)\tMEGESTROL (Hormone)\tNasal Cavity and Paranasal Sinuses Cancer pN2 TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Motion Parallax (Distance Perception)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as the arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.\nConcepts: Arteriovenous fistula maturation failure (Other Finding)\tanti-GITR MoAb BMS-986156 (Anti-GITR Monoclonal Antibody)\tAURC Infinity Predicted Normalized by Surface Area (Quantitative Concept)\tLocalised severe aggressive periodontitis (Disease or Syndrome)\tSequence Alignments (Genetic Techniques)", + "output": "Sequence Alignments (Genetic Techniques)" + }, + { + "input": "Definition: clathrin-coated vesicle membrane described as the lipid bilayer surrounding a clathrin-sculpted glutamate transport vesicle.\nConcepts: clathrin-sculpted glutamate transport vesicle membrane (Transport vesicle membrane)\tCSS0501A (Intellectual Product)\tMedium frequency (Heart Sound Categorized by Pitch)\tIRE1-DAB2IP complex location (protein-containing complex)\tPolyneuropathy associated with monoclonal immunoglobulin M antibodies to myelin-associated glycoprotein (Peripheral demyelinating neuropathy)", + "output": "clathrin-sculpted glutamate transport vesicle membrane (Transport vesicle membrane)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a sequence of single-stranded RNA, that is 20-25 nucleotides in length, which is transcribed from DNA but is not translated into a protein. This nucleic acid may regulate the transcription or translation of other genes.\nConcepts: Micro RNA (RNA, Small Untranslated)\tSecoviridae (Picornavirales)\tnegative regulation of cell proliferation involved in mesonephros development (negative regulation of mesonephros development)\tSite of New Primary Melanoma (Intellectual Product)\tMeans (Conceptual Entity)", + "output": "Micro RNA (RNA, Small Untranslated)" + }, + { + "input": "Definition: something described as an autonomic plexus that is derived from the celiac plexus, more specifically renal and hypogastric plexi, that accompanies the ureteric artery to the ureter\nConcepts: Sure (General Qualifier)\tVentricular Aneurysm Resection (Cardiovascular Surgical Procedures)\tStructure of ureteral plexus (Celiac Plexus)\tLytic Cycle (Virus Physiological Phenomena)\tSydnones (Oxadiazoles)", + "output": "Structure of ureteral plexus (Celiac Plexus)" + }, + { + "input": "Definition: E [Preparations] described as an orally bioavailable, non-steroidal estrogen naturally produced by the metabolism of the isoflavonoid daidzein by human intestinal microflora, with potential chemoprotective and estrogen receptor (ER) modulating activities. S-equol preferentially binds to and activates the beta isoform of ER in certain target tissues, while having an antagonistic effect in other tissues. This modulates the expression of ER-responsive genes in a tissue-specific manner. This agent may increase bone mineral density, affect vasomotor symptoms, and may decrease the proliferation rate of susceptible cancer cells. In addition, this agent interferes with the activity of enzymes involved in steroid biosynthesis. S-equol inhibits dihydrotestosterone (DHT) production and may inhibit the proliferation of androgen-driven prostate cancer. S-equol is the biologically active enantiomer while R-equol is essentially inactive and has a weak affinity for alpha-ER. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120313\" active clinical trials using this agent.\nConcepts: 1p13 (Cell Component)\t(2Z)-2,4-dihydroxydec-2-enedioate aldolase activity (oxo-acid-lyase activity)\tBlack Scour Worm (Trichostrongyloidea)\t2H-1-benzopyran-7-ol, 3,4-Dihydro-3-(4-hydroxyphenyl)-, (3S)- (E [Preparations])\tX: 151573740-151569863 (Spatial Concept)", + "output": "2H-1-benzopyran-7-ol, 3,4-Dihydro-3-(4-hydroxyphenyl)-, (3S)- (E [Preparations])" + }, + { + "input": "Definition: Urethral Anastomotic Leak, CTCAE described as severe symptoms; invasive intervention indicated\nConcepts: EQ5D02-Mobility (EQ-5D-5L Questionnaire Question)\tgerm-band extension (embryonic morphogenesis)\tGrade 3 Urethral anastomotic leak (Urethral Anastomotic Leak, CTCAE)\tN-(3-tert-Butyl-1-p-tolyl-1H-pyrazol-5-yl)-N'-(5-fluoro-2-(1-(2-hydroxyethyl)-1H-indazol-5-yloxy)benzyl)urea (Antineoplastic Enzyme Inhibitor)\tprotein localisation to cell tip (Cell Function)", + "output": "Grade 3 Urethral anastomotic leak (Urethral Anastomotic Leak, CTCAE)" + }, + { + "input": "Definition: Solvent Dosage Form Category described as liquid sterile preparation consisting of a solvent containing no active substances, intended for use in the preparation of a product for parenteral use. Comment: This term is only for use when describing a product that is authorised/marketed individually, and not to describe a manufactured item that is part of a product such as 'Powder and solvent for solution for injection'. In such cases, see instead 'Solvent for...'.\nConcepts: HT-Zip Domain (Amino Acid Sequence)\tEnvironmental Control Units (Medical Device)\tSolvent for parenteral use (Type of drug preparation)\tpilot projects (research)\ttype 1 cannabinoid receptor binding (cannabinoid receptor binding)", + "output": "Solvent for parenteral use (Type of drug preparation)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in genes associated with hypophosphatemic rickets, a form of rickets characterized by low levels of phosphate in the blood. Genetic variants at multiple loci have been associated with hypophosphatemic rickets. These reagents are intended to detect mutations in multiple hypophosphatemic rickets-associated loci simultaneously.\nConcepts: Angiogenetic Antagonist (Antineoplastic Agents)\tanterior olfactory nucleus, lateral part (Body Part, Organ, or Organ Component)\tAcral keratosis (Disorder of hand)\tHypophosphatemic Rickets Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Abnormal Mineralization Disorder, Rickets, Hypophosphatemic)\tElement, Group 2 (Elements)", + "output": "Hypophosphatemic Rickets Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Abnormal Mineralization Disorder, Rickets, Hypophosphatemic)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction.\nConcepts: MVE Freezer (Freezer)\tSou1p (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tTerbinafine (ANTIFUNGALS FOR SYSTEMIC USE)\tAIMS01-Severity of Abnormal Movements (Intellectual Product)\thTERT Vaccine V934/V935 (Pharmacologic Substance)", + "output": "Sou1p (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: something described as a response indicating that there was almost enough money left over to make ends meet.\nConcepts: Medicated swab (Medical Device)\tdilantin (Pharmacologic Substance)\tAlmost Enough to Make Ends Meet (Clinical or Research Assessment Answer)\t14: 61231992-61284729 (Chromosome 14 Physical Location)\tAbnormal G6PD level in blood (Finding)", + "output": "Almost Enough to Make Ends Meet (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Eye Disorder, Retinopathy, Macular Dystrophy, Stargardt Disease described as molecular assay reagents intended to identify mutations in genes associated with Stargardt disease, a form of macular dystrophy typically characterized by the accumulation of lipofuscin in cells underlying the macula, which leads to progressive central and night vision loss. Genetic variants at multiple loci have been associated with Stargardt disease. These reagents are intended to detect mutations in multiple Stargardt disease-associated loci simultaneously.\nConcepts: Stargardt Disease Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Eye Disorder, Retinopathy, Macular Dystrophy, Stargardt Disease)\tSupraglottic Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Supraglottic Cancer Pathologic TNM Finding v6)\tOs zygomaticum (Irregular bone)\tMEKK (Gene or Genome)\tsodium 4-phenylbutyrate (Central Nervous System Agents)", + "output": "Stargardt Disease Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Eye Disorder, Retinopathy, Macular Dystrophy, Stargardt Disease)" + }, + { + "input": "Definition: Lamiaceae described as a plant genus of the family CAMPANULACEAE used medicinally and is a source of LOBELINE.\nConcepts: brain atrophy (Atrophy/Degeneration affecting the central nervous system)\tFine-Lubinsky syndrome (Autosomal recessive hereditary disorder)\tlobelia (Campanulaceae)\tGMSS0114 (GMSS Version Type 1 Diabetes Questionnaire Question)\tE3 (LAPTM5 gene)", + "output": "lobelia (Campanulaceae)" + }, + { + "input": "Definition: something described as the histopathological evaluation of the liver based on the Meta-analysis of Histological Data in Viral Hepatitis (Metavir) scoring system.\nConcepts: Hamster Uterine Leiomyosarcoma (Hamster Neoplasm)\tSemaphorin 3D Gene (Gene or Genome)\tStage IA Breast Cancer (malignant neoplasm of breast stage I)\tOpportunistic bacterial infection (Disease or Syndrome)\tMETAVIR Fibrosis Score (Classification)", + "output": "METAVIR Fibrosis Score (Classification)" + }, + { + "input": "Definition: Disease or Syndrome described as blood coagulation disorder usually inherited as an autosomal recessive trait, though it can be acquired. It is characterized by defective activity in both the intrinsic and extrinsic pathways, impaired thromboplastin time, and impaired prothrombin consumption.\nConcepts: Inferior prosthion (Anatomical point)\terythema migrans chronicum (Disease or Syndrome)\tStuart-Prower; deficiency (Coagulation factor deficiency syndrome)\tKnowledge: Dementia Management (Finding)\tBenign tumor of peritoneum (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE DIGESTIVE SYSTEM)", + "output": "Stuart-Prower; deficiency (Coagulation factor deficiency syndrome)" + }, + { + "input": "Definition: something described as device that is controlled from a distance that passes electrical current through a circuit; current evokes or elicits action (response) in a muscle, gland, nerve or other excitable tissue.\nConcepts: Acute leukaemia, morphology, including blast cell OR undifferentiated leukaemia (Leukocyte Abnormalities, General and NEC)\tprotein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity (Molecular Function)\tnodal signaling pathway involved in determination of left/right asymmetry (Molecular Function)\tBCL3 (Gene or Genome)\tradio controlled electronic stimulator (electronic stimulator)", + "output": "radio controlled electronic stimulator (electronic stimulator)" + }, + { + "input": "Definition: CARTOX 10 Point Neurological Assessment described as a score of 10 on the CARTOX-10 assessment, indicating no neurotoxicity.\nConcepts: Structure of lacrimal nerve (Structure of ophthalmic nerve)\tGrade 4 Creatinine Increased, CTCAE (Finding)\tKnowledge: Allergy Management (Finding)\tEsophageal segment (Subdivision of esophagus)\tCARTOX No Neurological Impairment (CARTOX 10 Point Neurological Assessment)", + "output": "CARTOX No Neurological Impairment (CARTOX 10 Point Neurological Assessment)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as epidemiologic research on the environmental and genetic determinants of cancer.\nConcepts: Definitely disagree (Finding)\tMolecular Epidemiology of Cancer (Biomedical Occupation or Discipline)\tNephrogenic Adenoma of Urethra (Nephrogenic metaplasia)\tcyclins (Cell Cycle Proteins)\tsmooth muscle cell migration (Cell Function)", + "output": "Molecular Epidemiology of Cancer (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Central Nervous System described as generalized (diffuse, unlocalized) amyotrophy (muscle atrophy) affecting multiple muscles.\nConcepts: Epiblast (Other Embryologic Structure)\tReiki therapy (Complementary therapies)\tnegative regulation of optic nerve formation (regulation of optic nerve formation)\t(R)-malate hydro-lyase activity (Molecular Function)\tMuscular atrophy, generalized (Disease or Syndrome)", + "output": "Muscular atrophy, generalized (Disease or Syndrome)" + }, + { + "input": "Definition: Disease or Syndrome described as a laboratory test result indicating an abnormally high quantity of immature red blood cells.\nConcepts: Erythroid hyperplasia (Hyperplasia)\tGlucocorticoid Receptor Antagonist ORIC-101 (Antineoplastic Agents)\tSUPRACLAVICULAR FOSSA (Fossa)\tstructure tendon (Tendon and/or tendon sheath structure)\tPhosphorus, Dietary (Element, Ion, or Isotope)", + "output": "Erythroid hyperplasia (Hyperplasia)" + }, + { + "input": "Definition: Yao language - Bantu described as a Niger-Congo Bantu language spoken in Tanzania.\nConcepts: Sukuma (World languages)\thorseradish peroxidase (Staining method)\t/kg (Quantitative Concept)\thumanized human milk fat globule-1 monoclonal antibody (Amino Acid, Peptide, or Protein)\tArab Republic of Egypt (Geographic Area)", + "output": "Sukuma (World languages)" + }, + { + "input": "Definition: something described as a question about the extent to which an individual has or had unintentional release or leakage of urine.\nConcepts: regulation of mitotic spindle breakdown (Cell Function)\tAssisted insemination (Fertility and fertilisation interventions female)\textrinsic to organelle membrane (Cell Component)\tspermathecum morphogenesis (animal organ morphogenesis)\tHave Urinary Incontinence (Intellectual Product)", + "output": "Have Urinary Incontinence (Intellectual Product)" + }, + { + "input": "Definition: egress of virus within host cell described as the directed movement of a virus, or part of a virus, within the host cell cytoplasm via the host's actin filaments. Actin-dependent transport is induced by viral proteins that interact with actin and/or host cell motor proteins like myosins or that promotes actin polymerization/depolymerization reactions.\nConcepts: SCISSORS, EPISIOTOMY (Obstetrical/Gynecological scissors)\tProtein Expression Analysis by IHC (Laboratory Procedure)\tGrade 3 Pharyngeal Hemorrhage, CTCAE (Pharyngeal Hemorrhage, CTCAE)\tactin-dependent intracellular transport of viral material (egress of virus within host cell)\tJoint Range of Motion Decreased (Musculoskeletal and Connective Tissue Disorders, CTCAE)", + "output": "actin-dependent intracellular transport of viral material (egress of virus within host cell)" + }, + { + "input": "Definition: something described as AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of homosexual orientation\nConcepts: Saccades (Nystagmus)\tAIDS, Homosexual (AIDS Treatment Research)\tGlottic Cancer pM0 TNM Finding (Glottic Cancer Pathologic Distant Metastasis TNM Finding v6)\tHaemoglobin S -RETIRED- (Abnormal hemoglobin, beta-chain variant)\tANXA8 (Amino Acid, Peptide, or Protein)", + "output": "AIDS, Homosexual (AIDS Treatment Research)" + }, + { + "input": "Definition: Intellectual Product described as an international set of guidelines that helps make sure that the results of a clinical trial are reliable and that the patients are protected. Good Clinical Practice covers the way a clinical trial is designed, conducted, performed, monitored, audited, recorded, analyzed, and reported.\nConcepts: MMS202D (Intellectual Product)\tVehicle Transmission (Indirect Transmission)\tupregulation of neurological process (positive regulation of multicellular organismal process)\tGCRP (Clinical Practice Guideline)\tlipped (Gastrointestinal tract structure)", + "output": "GCRP (Clinical Practice Guideline)" + }, + { + "input": "Definition: something described as hormones produced by the GONADS, including both steroid and peptide hormones. The major steroid hormones include ESTRADIOL and PROGESTERONE from the OVARY, and TESTOSTERONE from the TESTIS. The major peptide hormones include ACTIVINS and INHIBINS.\nConcepts: 6-sulfanilamido-2,4-dimethoxypyrimidine (Sulfanilamides)\tC-SSRS Screening - Duration of Most Severe Ideation (Intellectual Product)\tTreatment Regimen #4 (Therapeutic or Preventive Procedure)\tGonadal Hormones (Endocrine substance, NOS)\tMycoplasma pulmonis (Mycoplasma)", + "output": "Gonadal Hormones (Endocrine substance, NOS)" + }, + { + "input": "Definition: Intellectual Product described as the 1.0 version of the FDA Clinical Endpoint BE Studies Technical Specifications Guidance.\nConcepts: GROSS LESION (Morphologically abnormal structure)\tViral Assembly (Virus Replication)\tUS FDA Clinical Endpoint BE Studies v1.0 (Intellectual Product)\tIntraepiderm SCC-Bowen's type (Intraepithelial Squamous Cell Carcinoma)\tvacuolar aspartate import (vacuolar transmembrane transport)", + "output": "US FDA Clinical Endpoint BE Studies v1.0 (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare hereditary hemolytic anemia due to a red cell membrane anomaly characterized by fatigue, mild anemia and pseudohyperkalemia due to a potassium leak from the red blood cells. A hallmark of this condition is that red blood cells lyse on storage at 4 degrees centigrade. There is evidence this disease is caused by heterozygous mutation in the SLC4A1 gene on chromosome 17q21.\nConcepts: Hereditary cryohydrocytosis with normal stomatin (Disease or Syndrome)\tGarlic Oil (Oils, Volatile)\tIndans (Organic Chemical)\tvirus factory (Inclusion Bodies, Viral)\tFeline Large Granular Lymphocyte Lymphoma (Neoplastic Process)", + "output": "Hereditary cryohydrocytosis with normal stomatin (Disease or Syndrome)" + }, + { + "input": "Definition: something described as serology reagents used in rapid tests to detect antigens or antibodies in a patient's sample to viruses belonging to the family Retroviridae. The most common subfamilies of pathogenic retroviruses are Oncovirinae, Spumavirinae, and Lentivirinae. Lentiviruses are the cause of acquired immunodeficiency syndrome (AIDS), and oncoviruses are associated with human T-Cell lymphomas and leukemia.\nConcepts: IVD Test Reagent/Kits, Serology, Rapid Test, Virus, Retrovirus (IVD Test Reagent/Kits, Serology, Rapid Test, Virus)\tDuodenum and Ampulla of Vater Neuroendocrine Tumor pT2 TNM Finding v8 (Duodenum and Ampulla of Vater Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8)\tmiR-509-5p (Biologically Active Substance)\tposterior part of the dorsomedial hypothalamic nucleus (Structure of dorsomedial hypothalamic nucleus)\t4-(Aminobutyl)guanidine (Organic Chemical)", + "output": "IVD Test Reagent/Kits, Serology, Rapid Test, Virus, Retrovirus (IVD Test Reagent/Kits, Serology, Rapid Test, Virus)" + }, + { + "input": "Definition: Nail abnormality described as nail whose growth pattern or speed deviates from normal.\nConcepts: Abnormal nail growth (Nail abnormality)\tST (Intellectual Product)\tCTRB2 (Peptidase Gene)\tLHRHR (G Protein-Coupled Receptor Genes)\tenvenomation resulting in negative regulation of circulating fibrinogen in other organism (Biologic Function)", + "output": "Abnormal nail growth (Nail abnormality)" + }, + { + "input": "Definition: something described as instruments designed to trap, retrieve, and/or manipulate stones for the treatment of conditions such as cholelithiasis (i.e., presence of calculi in the bile duct or gallbladder). These instruments typically comprise a flexible sheath with a multiwire, self-expanding (typically nitinol) basket at the distal end and a handle at the proximal end designed to open, close, and rotate the basket. These devices are intended to be used through the working channel of an endoscope in procedures such as endoscopic retrograde cholangiopancreatography (ERCP) or laparoscopic cholecystectomy.\nConcepts: What is the Status of the Residual Tumor After Surgery for New Tumor Event (Intellectual Product)\tBaskets, Retrieval, Biliary Stone (Endoscopes)\tFAC071-Frustrated by Being Too Tired (FACIT-F Version 4 Questionnaire Question)\tFentanyl Citrate Pectin-Based Nasal Spray (Opioid Receptor Agonist)\tParagonimus species (Eukaryote)", + "output": "Baskets, Retrieval, Biliary Stone (Endoscopes)" + }, + { + "input": "Definition: Biologic Function described as increased capacity to repair radiation-induced DNA damage; a heritable property of certain tumor cells and normal cells; determinating factors are oncogenes, tumor metabolic state and vascular supply.\nConcepts: Postnatal growth retardation, severe (Finding)\tBile Duct Disorder (Hepatobiliary Disorder)\tCMLE activity (intramolecular lyase activity)\tbiological radiation resistance (Biologic Function)\tFuG (Cortex of occipital lobe)", + "output": "biological radiation resistance (Biologic Function)" + }, + { + "input": "Definition: something described as a complex substitution where the nucleotide sequence at positions 35 and 36 of the coding sequence of the HRAS gene has changed from guanine-cytosine to adenine-thymine.\nConcepts: Acrocephalopolysyndactyly Type II (Acrocephalosyndactylia)\tIntramedullary Route of Drug Administration (RouteBySite)\tHarvey Rat Sarcoma Viral Oncogene Homolog c.35 36GC>AT (H-ras gene mutation)\tGDS - Feel Happy Most of Time (Intellectual Product)\tElevated gamma-glutamyltransferase level (Abnormal enzyme/coenzyme activity)", + "output": "Harvey Rat Sarcoma Viral Oncogene Homolog c.35 36GC>AT (H-ras gene mutation)" + }, + { + "input": "Definition: something described as species of the genus MASTADENOVIRUS that causes fever, edema, vomiting, and diarrhea in dogs and encephalitis in foxes. Epizootics have also been caused in bears, wolves, coyotes, and skunks. The official species name is Canine adenovirus and it contains two serotypes.\nConcepts: Ts and As - Tonsils & adenoids (Tonsillectomy and/or adenoidectomy)\tCasparian strip (cellular anatomical entity)\tViruses, Canine Hepatitis (Virus)\tVascular Aorta Artery Stylets (Stylets, Vascular, Artery)\tHUP48 (Gene or Genome)", + "output": "Viruses, Canine Hepatitis (Virus)" + }, + { + "input": "Definition: something described as hypophosphatemic rickets due to mutation(s) in the X-chromosomal CLCN5 gene, encoding H(+)/Cl(-) exchange transporter 5. This condition is expressed in male individuals hemizygous for the mutation(s), and in female individuals homozygous for the mutation(s). The disorder of the proximal renal tubules is characterized by low-molecular weight proteinuria, hypercalciuria, renal phosphate wasting, nephrocalcinosis, nephrolithiasis, progressive kidney failure, and elevated 1,25-dihydroxyvitamin D (calcitriol) concentrations.\nConcepts: Visual Perception (Vision)\tSpinocerebellar ataxia type 40 (Ataxia, Spinocerebellar)\tDent's Disease (Hereditary nephropathy)\tFLJ13660 (Genes, cdc)\tMDS-UPDRS - Dressing (Intellectual Product)", + "output": "Dent's Disease (Hereditary nephropathy)" + }, + { + "input": "Definition: Shoulder described as the paired bone that is situated between the sternum and the shoulder.\nConcepts: retrograde trans-synaptic signaling by lipid (retrograde trans-synaptic signaling)\tPPP1R74 (Gene or Genome)\tnegative regulation of astrocyte chemotaxis (negative regulation of glial cell migration)\tClavicle/Clavicular (Body part)\tdown regulation of triacylglycerol transport (regulation of triglyceride transport)", + "output": "Clavicle/Clavicular (Body part)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions and duplications in genes associated with xeroderma pigmentosum, a disorder caused by defects in DNA damage repair systems and characterized by sensitivity of the skin to ultraviolet light exposure. Genetic variants at multiple loci have been associated with xeroderma pigmentosum. These reagents are intended to detect deletions and duplications in multiple xeroderma pigmentosum-associated loci simultaneously.\nConcepts: GLRX5 (glutaredoxin 5) related sideroblastic anaemia (Disease or Syndrome)\tMeasure of duration of menstrual cycle (Duration measure of menstruation)\tIVD Panels, Human Genetics, Multisystem Disorder, Xeroderma Pigmentosum, Del/Dup (Medical Device)\tHER-2-neu, CEA peptides, GM-CSF, Montanide ISA-51 vaccine (Agent Combination Not Indexed in Open Clinical Trials)\tGNA13 wt Allele (GNA13 gene)", + "output": "IVD Panels, Human Genetics, Multisystem Disorder, Xeroderma Pigmentosum, Del/Dup (Medical Device)" + }, + { + "input": "Definition: Hypocalcemia Severity described as a sharp pain that occurs when a muscle suddenly contracts (tightens up). Cramps commonly occur in the abdomen and legs.\nConcepts: Cramp, Muscle (General finding of soft tissue)\tStructure of Descemet membrane (Corneal Endothelium)\tEndoscopic Microsurgeries, Transanal (Transanal Endoscopic Surgery)\tFAC099TN (Intellectual Product)\tACID PHOSPHATASE, THYMOLPHTHALE INMONOPHOSPHATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "Cramp, Muscle (General finding of soft tissue)" + }, + { + "input": "Definition: something described as serine/threonine-protein kinase 3 (491 aa, ~56 kDa) is encoded by the human STK3 gene. This protein plays a role in the mediation of both protein phosphorylation and signaling.\nConcepts: SERRATIA ODORIFERA (Serratia)\tBiemond syndrome type 2 (Intellectual Disability)\tMST-2 (Enzyme)\tLymphedema Management (Therapeutic or Preventive Procedure)\t14q12 (Cell Component)", + "output": "MST-2 (Enzyme)" + }, + { + "input": "Definition: something described as a point in time that indicates the beginning of a procedure.\nConcepts: CDISC Questionnaire C-SSRS Children's Baseline Test Name Terminology (Intellectual Product)\tDefinition Class Scheme Item (UML Entity)\tPRSTTPT (Temporal Concept)\tFluorine F 18 BMS-986229 (Indicator, Reagent, or Diagnostic Aid)\tNeural Growth (Nervous System Physiological Phenomena)", + "output": "PRSTTPT (Temporal Concept)" + }, + { + "input": "Definition: Genetic Inheritance described as a mode of inheritance that is observed for traits related to a gene encoded on the mitochondrial genome. Because the mitochondrial genome is essentially always maternally inherited, a mitochondrial condition can only be transmitted by females, although the condition can affect both sexes. The proportion of mutant mitochondria can vary (heteroplasmy).\nConcepts: Caring for teeth (Daily or Recreational Activity)\tBEBQ01-Baby Is Always Demanding a Feed (Intellectual Product)\tMitochondrial inheritance (organelle inheritance)\tDisorder of mandibular and maxillary dental arch relationship (Micrognathism)\tNISCHARIN (Gene or Genome)", + "output": "Mitochondrial inheritance (organelle inheritance)" + }, + { + "input": "Definition: Cardiovascular finding described as a decrease in blood supply caused by blockage of blood vessel\nConcepts: Did your family receive free/subsidized school lunch (Intellectual Product)\tPapillomavirus regulatory factor 1 protein, human (Amino Acid, Peptide, or Protein)\tVaginal Basaloid Carcinoma (Basaloid squamous cell carcinoma)\tISCHEMIA (Perfusion finding)\ttranslation initiation factor activity (translation factor activity, RNA binding)", + "output": "ISCHEMIA (Perfusion finding)" + }, + { + "input": "Definition: Pathologic Function described as the structural changes in the number, mass, size and/or composition of the airway tissues.\nConcepts: propionyl coenzyme A carboxylase activity (Molecular Function)\tFAC006-I Am Able to Work (FACT-BL Version 4 Questionnaire Question)\tAirway Remodelling (Respiratory physiology)\tSternoclavicular device adju (Therapeutic or Preventive Procedure)\tMutation Analysis (Molecular Genetic Technique)", + "output": "Airway Remodelling (Respiratory physiology)" + }, + { + "input": "Definition: SULT1C2 gene described as human SULT1C2 wild-type allele is located in the vicinity of 2q12.3 and is approximately 21 kb in length. This allele, which encodes sulfotransferase 1C2 protein, is involved in the metabolism of hormones, xenobiotics and ribonucleotides.\nConcepts: PGH2 (Prostaglandins)\tprotein maturation (Cell Function)\tPolygonum punctatum Elliott (Western herbs and natural substances letter P)\tSULT1C2 wt Allele (Gene or Genome)\tbreast; carcinoma, intraductal papillary (Papillary carcinoma of the breast)", + "output": "SULT1C2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as the integumentary covering of the upper limb and shoulder region.\nConcepts: Biomedical materials (Biomedical or Dental Material)\tSkin of arm and shoulder (Skin, Human)\tReflex, Absent (Reflex, Abnormal)\tLanguages, Programming (Languages)\tVentral sacroiliac ligament (Ligaments)", + "output": "Skin of arm and shoulder (Skin, Human)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as collagen alpha-2(IV) chain (1712 aa, ~168 kDa) is encoded by the human COL4A2 gene. This protein is involved in basement membrane formation.\nConcepts: Gastric Carcinoma cM0 TNM Finding v8 (Gastric Cancer Clinical Distant Metastasis TNM Finding v8)\toculogyric; crisis (Miscellaneous Common Eye and Eyelid Symptoms)\tacylglycerone-phosphate reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tSeminoma of the Mediastinum (Malignant germ cell neoplasm of mediastinum)\tCollagen Type IV Alpha-2 Chain (COL4A2 Gene Product)", + "output": "Collagen Type IV Alpha-2 Chain (COL4A2 Gene Product)" + }, + { + "input": "Definition: something described as proving a patient with hospice care. For additional time, use NAATK. Service is billed in 60-minute increments.\nConcepts: FACT-B Version 4 - Worry My Condition Will Get Worse (Intellectual Product)\tPrescribing, Inappropriate (Pharmacotherapy)\tHospice care initial 60 minutes (Therapeutic or Preventive Procedure)\tEnergy estimated intake from oral nutrition in 24 hours (Quantitative Concept)\tFilling, Aseptic, Powder, Isolator Process (Filling Method)", + "output": "Hospice care initial 60 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Nutraceuticals described as a multi-organ, animal-based dietary supplement used to help strengthen, support and improve heart functions. This product is used prior to taking CellLife(TM) Forever Heart 2 Support in cases of severe heart problems.\nConcepts: Naevus;intradermal (Acquired melanocytic nevus)\tAffects (Psychological function)\tCellLife(TM) Forever Heart 1 Support multi-organ each 3 ml bottle (Pharmacologic Substance)\tCandida boidinii C. Ramirez, 1953 (Candida)\tSeminal Vesicle Secretory Proteins (Amino Acid, Peptide, or Protein)", + "output": "CellLife(TM) Forever Heart 1 Support multi-organ each 3 ml bottle (Pharmacologic Substance)" + }, + { + "input": "Definition: Allocortex described as a composite substructure of the limbic lobe defined on the basis of dissection and internal structure as revealed by Nissl stain. In the human and the macaque it includes the hippocampal formation, the fasciola cinerea, the supracallosal gyrus and the paraterminal gyrus ( Stephan-1975 ). It constitutes 3.5% of the surface area of the cerebral cortex ( Zilles-1990 ). See also hippocampal region.\nConcepts: Suture Dose Form (Biomedical or Dental Material)\tGranular Cell Leiomyosarcoma (leiomyosarcoma)\tSEXUAL DESIRE INCREASED (Sexual Problems of the Second Decade)\tArchipallium (Allocortex)\tBilateral trilobed lungs due to isomerism of right lung (Trilobed left lung)", + "output": "Archipallium (Allocortex)" + }, + { + "input": "Definition: Quantitative Concept described as a dosing measurement based on the cigarette unit.\nConcepts: HAQ0126 (Intellectual Product)\tCart Washer/Sterilizers (Washer/Sterilizing Units)\tCigarette Dosing Unit (Potency Unit)\tMalva (Malvaceae)\tSER401 (Biological Response Modifiers)", + "output": "Cigarette Dosing Unit (Potency Unit)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Was {S} left away from home, for 15 minutes or longer, during the day?\nConcepts: Acquired Factor IX Deficiency (Hemophilia B)\tADL03-Left Away From Home (ADCS-ADL MCI Questionnaire Question)\tthyroid hormone catabolism (hormone catabolic process)\tendonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (endonucleolytic cleavage of tricistronic rRNA transcript)\tAntigens, CD33 (Clusters of differentiation)", + "output": "ADL03-Left Away From Home (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: something described as responding in a similar manner to different stimuli which have some common physical property. Also known as primary generalization. Compare GENERALIZATION (LEARNING) and RESPONSE GENERALIZATION.\nConcepts: Evaluates verification process for correct patient, procedure, site, side, and level surgery (Safety)\tstimulus generalization (Learning Generalization)\tMPP1 protein, human (Biologically Active Substance)\tbone (Anatomical set)\tMETHYLMALONIC ACIDURIA, cblB TYPE (Methylmalonic acidemia)", + "output": "stimulus generalization (Learning Generalization)" + }, + { + "input": "Definition: positive regulation of gene silencing by miRNA described as any process that activates or increases the frequency, rate or extent of production of miRNAs involved in gene silencing by miRNA.\nConcepts: DNA Damage-Binding Protein b (DNA repair protein)\tCrangonidae (Eukaryote)\tdental implant [device] (Intraoral maxillofacial prosthesis)\tpositive regulation of production of miRNAs involved in gene silencing by miRNA (Genetic Function)\tauxin mediated signalling (Molecular Function)", + "output": "positive regulation of production of miRNAs involved in gene silencing by miRNA (Genetic Function)" + }, + { + "input": "Definition: something described as an agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.\nConcepts: Hirsutism - hypertrichosis (Skin, Human)\tBuchnera (Bacterium)\tL-pipecolate oxidase activity (oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor)\tDigital Imaging Systems, Computed Radiography (Image Digitization Systems)\tQuisqualic Acid (Oxadiazoles)", + "output": "Quisqualic Acid (Oxadiazoles)" + }, + { + "input": "Definition: Lamiaceae described as a genus of the LAMIACEAE family. It is known for its mild calming effect and for the way cats are attracted to the aroma.\nConcepts: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child - Wake Up Tired (Intellectual Product)\tField Balm (Labiate family)\t22q13.31 (Chromosome band)\tenvenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism (envenomation resulting in modulation of receptor activity in other organism)\tAlveolar air (Body Substance)", + "output": "Field Balm (Labiate family)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a rare primary immunodeficiency due to a defect in adaptive immunity characterized by the absence of CD8 positive T cells with normal immunoglobulin and specific antibody titers in blood and susceptibility to recurrent respiratory bacterial and viral infections. Symptom severity ranges from fatal respiratory insufficiency to mild or asymptomatic phenotypes.\nConcepts: Board (Organization)\tnegative regulation of cell communication (Cell Function)\tCalcification of coronary arteries (Vascular)\tReproductive Physiology (Biomedical Occupation or Discipline)\tCD8 Deficiency, Familial (Autosomal recessive hereditary disorder)", + "output": "CD8 Deficiency, Familial (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: Intellectual Product described as barnes Akathisia Rating Scale test code.\nConcepts: androgen receptor antagonist SHR3680 (Androgen Receptor Inhibitor)\tInhalation Strain (Somatic dysfunction of rib)\tQS-BARS TESTCD (Intellectual Product)\tME (Quantitative Concept)\tvylns mgmt (Common nursing interventions)", + "output": "QS-BARS TESTCD (Intellectual Product)" + }, + { + "input": "Definition: something described as a laboratory test result indicating the presence of HLA-A*01 positive cells in a tissue sample.\nConcepts: Durie/Salmon Stage (Disease Stage Qualifier)\tBradyrhizobium species (Bradyrhizobium)\tHLA-A1 Positive Cells Present (Finding)\tChambers, Laboratory, Thermostatic Controlled, Chromatography Column (Chamber)\tExperimental Sampling (Statistical Theory & Experimentation)", + "output": "HLA-A1 Positive Cells Present (Finding)" + }, + { + "input": "Definition: Anatomical Abnormality described as a structural anomaly of the growth plates (epiphyseal plates), areas of cartilage located near the ends of long bones that are located between the metaphysis (widened part of the shaft of the bone) and the epiphysis (end of the bone) and in which growth occurs in the developing bone. After conclusion of bone growth, the growth plates ossify (harden into solid bone). []\nConcepts: Tranquillizing Agents (Tranquilizers and Antidepressant Drugs)\tb-Hexachlorobenzene (Hazardous or Poisonous Substance)\tAbnormality of growth plate morphology (Anatomical Abnormality)\tCavernitides, Fibrous (Disease or Syndrome)\tSulphonamide -class of antibiotic- (Antibiotics)", + "output": "Abnormality of growth plate morphology (Anatomical Abnormality)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase.\nConcepts: Molybdenum (Dietary Molybdenum)\taorta dissections (Aneurysm, Dissecting)\tBoxing (Activities involving other specified sports and athletics)\tnickel-tetrapyrrole coenzyme metabolic process (tetrapyrrole metabolic process)\tWRIGHT STAIN (Staining technique)", + "output": "nickel-tetrapyrrole coenzyme metabolic process (tetrapyrrole metabolic process)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C415\" active clinical trials using this agent.\nConcepts: Catheters, Intracranial, Ventricular, Hydrocephalic (Medical Device)\tDiphenasone (Sulfur and sulfur compound-containing product)\tlateral tegmental nucleus (Body Part, Organ, or Organ Component)\tMitogen Activated Protein Kinase (Proline-Directed Protein Kinases)\tRRP (Synaptic Vesicles)", + "output": "Diphenasone (Sulfur and sulfur compound-containing product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule.\nConcepts: serine O-acyltransferase activity (Molecular Function)\tNR3C1 Gene (Gene or Genome)\tT-cell lymphoma stage IV (T-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage)\toncology, dermatologic (oncology field)\tPedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Hard for Family to Plan Activities (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report Questionnaire Question)", + "output": "serine O-acyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Cell Function described as any mesenchymal cell apoptotic process that is involved in metanephric nephron morphogenesis.\nConcepts: Cilia and Flagella Associated Protein 39 (Translocase)\tPhenomenons, Virus Physiological (Biological Processes)\tObs of bleeding of nose (Hemorrhage of blood vessel)\tPhysiologic motion (Clinical Attribute)\tmesenchymal cell apoptotic process involved in metanephric nephron morphogenesis (mesenchymal cell apoptotic process involved in nephron morphogenesis)", + "output": "mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis (mesenchymal cell apoptotic process involved in nephron morphogenesis)" + }, + { + "input": "Definition: Antitussive Agents described as a traditional East Asian herbal medicine composed of six herbs, including Ophiopogonis tuber, Pinelliae tuber, Glycyrrhizae radix, Zizyphi fructus, Ginseng radix, and Oryzae semen, with potential anti-tussive activity. Maekmoondong-tang is traditionally prescribed for respiratory symptoms to direct the qi downwards and compensate for lung-yin deficiency or dry lung by tonifying yin and moistening the lung. Although the exact mechanisms through which Maekmoondong-tang exerts its effects have yet to be fully elucidated, this agent may, upon administration, improve the severity of chronic cough, reduce airway hyper-responsiveness possibly by reducing the cough reflex and bronchodilation, and airway inflammation possibly through anti-inflammatory and immunomodulatory effects.\nConcepts: Maekgeuron Granules (Organic Chemical)\tTMEM70 related mitochondrial encephalo-cardio-myopathy (Neonatal metabolic disorder)\tHypopharyngeal Cancer pN3 TNM Finding v7 (Finding)\tProduct containing iodine AND/OR iodine compound (I [Preparations])\tCounselling about nutrition using social learning theory approach (Therapeutic or Preventive Procedure)", + "output": "Maekgeuron Granules (Organic Chemical)" + }, + { + "input": "Definition: plasma membrane protein complex described as a protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.\nConcepts: inositol tetrakisphosphate phosphatase activity (inositol phosphate phosphatase activity)\tRDQ01-Use Handrail to Get Upstairs (RDQ Questionnaire Question)\talphav-beta3 integrin-PKCalpha complex (Cell Component)\tplannedChangeIndicator (Qualitative Concept)\tdinucleotide repeat insertion binding (dinucleotide insertion or deletion binding)", + "output": "alphav-beta3 integrin-PKCalpha complex (Cell Component)" + }, + { + "input": "Definition: kinase activity described as catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+).\nConcepts: IPAQ Long Last 7 Days Telephone Format Version - Moderate Work Hours per Day (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tLENS, SPECTACLE (PRESCRIPTION), FOR READING DISCOMFORT (Medical Device)\toxidoreductase activity, oxidizing metal ions with flavin as acceptor (oxidoreductase activity, oxidizing metal ions)\tBox (Manufactured Object)\ttaurocyamine phosphotransferase activity (Molecular Function)", + "output": "taurocyamine phosphotransferase activity (Molecular Function)" + }, + { + "input": "Definition: Antibiotic described as an antitumor antibiotic of the enediyne class. It has demonstrated high DNA cleavage activity in the presence of NADPH, antimicrobial and tumor growth-inhibiting properties. Dynemicin recognizes and cleaves conformationally flexible regions of DNA. It attacks bases at 3'-side of purine residues such as 5'-AG, 5'-AT, and 5'-GC sequences.\nConcepts: Follicular lymphoma, grade 3B (Lymphoma, Follicular, Grade 3)\tFlorigen (Plant Proteins)\tnegative regulation of response to benzene (regulation of response to benzene)\tDynemicin (Enediyne Antineoplastic Antibiotic)\tradiation enteritis (Intestinal Diseases)", + "output": "Dynemicin (Enediyne Antineoplastic Antibiotic)" + }, + { + "input": "Definition: Otitis Externa, CTCAE described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated\nConcepts: FA Complementation Group G Gene (FA Complementation Group Gene)\tLymphoid cholangitis (Disease or Syndrome)\tN-terminal peptidyl-isoleucine methylation (Molecular Function)\tSaccular conjunctival dilatations (Abnormal morphology of the conjunctival vasculature)\tGrade 3 Otitis Externa, CTCAE (Finding)", + "output": "Grade 3 Otitis Externa, CTCAE (Finding)" + }, + { + "input": "Definition: something described as a genetic disorder that affects the adrenal gland. It includes adrenal gland hyperplasia and adrenal gland hypoplasia.\nConcepts: Infant Acute Lymphoblastic Leukemia with MLL Rearrangement (Neoplastic Process)\tIdarubicin-Fludarabine-AraC/G-CSF Regimen (Chemotherapy Regimen Used to Treat Childhood Acute Myeloid Leukemia)\tFeel in Complete Control of Breathing Problems (Clinical or Research Assessment Question)\tCongenital Adrenal Gland Disorder (Non-Neoplastic Adrenal Gland Disorder)\tColon or Rectum Neuroendocrine Tumor cM1 TNM Finding v7 (Finding)", + "output": "Congenital Adrenal Gland Disorder (Non-Neoplastic Adrenal Gland Disorder)" + }, + { + "input": "Definition: something described as posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor.\nConcepts: Influenza Type B Virus Positive (Laboratory or Test Result)\tGDS - More Memory Problems Than Most (GDS Questionnaire Question)\t1,2-beta-D-fructan:1,2-beta-D-fructan 1F-beta-D-fructosyltransferase activity (Molecular Function)\tRNA methylation (RNA modification)\tselective mutism (Disorders of social functioning with onset specific to childhood and adolescence)", + "output": "RNA methylation (RNA modification)" + }, + { + "input": "Definition: Plant described as cang zhu, bai zhu\nConcepts: Breast Infection, CTCAE (Infections and Infestations, CTCAE)\tInfections, Oxyurida (Secernentea Infections)\tresponse to high fluence blue light stimulus by blue high-fluence system (response to high light intensity)\tAtractylodes lancia / cang zhu / bai zhu (Plant)\tRadish bacillus (Bacterium)", + "output": "Atractylodes lancia / cang zhu / bai zhu (Plant)" + }, + { + "input": "Definition: something described as using homeopathic assessment methods in a simple, 15-minute, in-office meeting to assess the health status of a new homeopathy client to develop a homeopathic treatment plan.\nConcepts: Slipped capilal femoral epiphysis (Limb structure)\tNSF (Connective Tissue Diseases)\tIL2RA gene (Cytokine Receptor Gene)\tneutrophil mediated killing of symbiont cell (Cell Function)\tSimple new 15 minutes in-office homeopathic intake (New client in-office without ICD diagnosis)", + "output": "Simple new 15 minutes in-office homeopathic intake (New client in-office without ICD diagnosis)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in fatty acid oxidation.\nConcepts: HACL1 (Gene or Genome)\tmsg therp ref.nc (Health Care Activity)\tTerminology Concept (Intellectual Product)\tcreatinine metabolic process (organonitrogen compound metabolic process)\tPermanent lower right first molar tooth (Structure of right half of body)", + "output": "HACL1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a regimen consisting of fludarabine, mitoxantrone and dexamethasone used to treat indolent non-Hodgkin lymphoma.\nConcepts: Erythropoetin (Hormone)\tInjections, Intra Ocular (Injection Route of Drug Administration)\tregulation of signaling receptor activity (regulation of molecular function)\tasymmetric neuroblast division (neuroblast division)\tDexamethasone-Fludarabine-Mitoxantrone (Therapeutic or Preventive Procedure)", + "output": "Dexamethasone-Fludarabine-Mitoxantrone (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a chromosome band present on Xp\nConcepts: RPAP3/R2TP/prefoldin-like complex location (protein-containing complex)\tnegative regulation of retrograde axon cargo transport (regulation of retrograde axon cargo transport)\tXp11.4-p11.21 (Chromosome band)\tERYTHROBLASTOSIS FETALIS (Erythroblastosis, Fetal)\tDate stopped (Date in time)", + "output": "Xp11.4-p11.21 (Chromosome band)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the prolymphocytes in a biological specimen.\nConcepts: pyrimidine deoxyribonucleoside salvage (pyrimidine nucleoside salvage)\tInquilinus limosus (Bacterium)\tprolymphocyte count (Laboratory Procedure)\tCorneal dellen (Non-Neoplastic Corneal Disorder)\tHayfever (Allergic rhinitis)", + "output": "prolymphocyte count (Laboratory Procedure)" + }, + { + "input": "Definition: Eyelid Neoplasms described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C88133\" active clinical trials using this agent.\nConcepts: Undercollimation (Collimation Error)\tMOR209/ES414 (Amino Acid, Peptide, or Protein)\tmyeloid cell homeostasis (homeostasis of number of cells)\tCutaneous Assessment Tool (Intellectual Product)\tstage IV eyelid carcinoma (Eyelid Neoplasms)", + "output": "stage IV eyelid carcinoma (Eyelid Neoplasms)" + }, + { + "input": "Definition: something described as the Epidemiology and Cancer Control Shared Resource provides consultation and support to the Cancer Center investigators conducting research projects related to cancer epidemiology and control, health behavior and quality of life research, and molecular and clinical oncology. Areas of support are, but not limited to: study design, data collection, quality control and analysis, software and measurement error models development, statistical programming, and interpretation and dissemination of results.\nConcepts: FACT-B Version 4 - Self-conscious About Way I Dress (FACT-B Version 4 Questionnaire Question)\tphosphonates (Phosphorus Compounds, Unspecified)\tQIDSC1-Appetite (QIDS-C Clinical Classification Question)\tEpidemiology and Cancer Control Shared Resource (Health Care Related Organization)\tMAT complex (Cell Component)", + "output": "Epidemiology and Cancer Control Shared Resource (Health Care Related Organization)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 3 Months Version - We would like to know how your respiratory problems usually affect your daily life: I cannot play sports or do other physical activities.\nConcepts: Medial Meniscus (Knee meniscus structure)\tHalf Maximal Inhibitory Concentration Fold Change from Baseline Measurement (Laboratory Procedure)\tSGRQ0146 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tBreak, Single-Stranded DNA (DNA Breaks)\t2''-aminoglycoside nucleotidyltransferase activity (aminoglycoside nucleotidyltransferase activity)", + "output": "SGRQ0146 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)" + }, + { + "input": "Definition: CPTAC Responses described as a response indicating that physician diagnosed diabetes is absent.\nConcepts: Physician Diagnosed Diabetes Absent (Finding)\tinitiation of dorsal closure (Organism Function)\tAssesses risk factors for infection (Physiologic Responses)\tAbnormally Displaced Point of Maximum Impulse (Finding)\tStudyOutcomeMeasure (Measurement)", + "output": "Physician Diagnosed Diabetes Absent (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of etoposide, ifosfamide, mitoxantrone and dexamethasone used for treatment of relapsed or refractory Hodgkin Lymphoma.\nConcepts: HAMD3-Suicidal Thoughts (HAMD 24 Clinical Classification Question)\tAwls, Cartilage (Medical Device)\thypnoTx strs mgmt ndvdl ea.1 (Hypnotherapy and/or meditation)\tVP-16/Ifosfamide/Mitoxantrone/Dexamethasone (Regimen Used to Treat Hodgkin Lymphoma)\t(s)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one (Non-nucleoside reverse transcriptase inhibitors)", + "output": "VP-16/Ifosfamide/Mitoxantrone/Dexamethasone (Regimen Used to Treat Hodgkin Lymphoma)" + }, + { + "input": "Definition: Telomere Maintenance described as telomeres in human cancer cells consist of a tandem array of telomeric DNA repeats bound to a specialized telomeric proteins. Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. Both telomerase and recombination can lengthen telomeres.\nConcepts: Support Vector Machine (Supervised Machine Learning)\tB-Lymphoblastic Leukemia/Lymphoma with Hypodiploidy (B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities)\tHepatocyte Nuclear Factor 1-alpha (Biologically Active Substance)\tdown-regulation of female receptivity, post-mating (negative regulation of female receptivity)\tLength Maintenance (Telomere Maintenance)", + "output": "Length Maintenance (Telomere Maintenance)" + }, + { + "input": "Definition: something described as absence of distal phalanx of the second toe as a result of developmental aplasia.\nConcepts: Anti-ds-DNA Antibodies (Serum Autoantibody Test)\tbase (GENERAL CHEMICAL TERMS)\tAbsent distal phalanx of the 2nd toe (Aplasia of the phalanges of the 2nd toe)\tSelf-Responsibility Facilitation (Motivating patient)\tYeast brewer's (Non-Standardized Food Allergenic Extract)", + "output": "Absent distal phalanx of the 2nd toe (Aplasia of the phalanges of the 2nd toe)" + }, + { + "input": "Definition: something described as monoterpenes that include a cyclopentane ring in their structure.\nConcepts: Breast Cancer-Related Arm Lymphedema (Lymphedema)\tDifferentiation Proteins Inhibitor (Biologically Active Substance)\tIPAQ Long Last 7 Days Self-Administered Format Version - Moderate Leisure Minutes per Day (Intellectual Product)\tMicrobiology Specimen Link Identifier (Record Link Identifier)\tMonoterpenes, Cyclopentane (Organic Chemical)", + "output": "Monoterpenes, Cyclopentane (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Child Report (PedsQL Neuromuscular Module Acute Version 3.0 Child Report) In the past 7 days, how much of a problem has this been for you: It is hard to breathe.\nConcepts: PQL1401 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)\tMultiple Identity Disorders (Dissociative disorder)\tAbsorption (Physical Phenomenon or Property)\tOcular Adnexal Lymphoma pM1c TNM Finding v7 (Finding)\tR360133 (Intellectual Product)", + "output": "PQL1401 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)" + }, + { + "input": "Definition: Social Perception described as process by which an individual transforms various perceptions and observations about another person or group into an overall impression or set of attitudes toward or about that person or group.\nConcepts: Olfactory Membranes (Tissue)\tImpression Formation (Social Perception)\tModified beverage, medical food supplement therapy (Medical food supplement therapy)\thydrencephaly (CNS disorder)\tchronic sorrow (Sad mood)", + "output": "Impression Formation (Social Perception)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 5 on a well-being scale that ranges from 0: No Well-Being to 10: Worst Possible Well-Being.\nConcepts: Monitors, Physiologic, Central Station (Medical Device)\tgamma-glutamylaminecyclotransferase activity (Molecular Function)\tT-Cell Lymphoma Invasion and Metastasis 1 wt Allele (TIAM1 gene)\tWell-Being Score 5 (Well Being Visual Analogue Scale)\tmutationTypeCode (Intellectual Product)", + "output": "Well-Being Score 5 (Well Being Visual Analogue Scale)" + }, + { + "input": "Definition: FACT-Taxane Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Taxane Version 4 (FACT-Taxane Version 4) Social/Family Well-Being: My family has accepted my illness.\nConcepts: FACT-Taxane Version 4 - My Family Has Accepted My Illness (FACT-Taxane Version 4 Questionnaire Question)\tType III Epithelial Receptor Cell (Taste bud cell)\tCorticosterone Methyl Oxidase Deficiency Type 2 (Aldosterone Synthase Deficiency)\tPethidine hydrochloride [anaesthesia] (meperidine)\tRecurrent Cerebellar Astrocytoma (Neoplastic Process)", + "output": "FACT-Taxane Version 4 - My Family Has Accepted My Illness (FACT-Taxane Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as a particular category of a regulatory submission regarded as having particular characteristics, purposes, and causing different regulatory requests.\nConcepts: hospital organization/administration (Health Care Activity)\tviral infectious cycle (viral process)\tMOTPTREF (Reference Time Point)\tRegulatory Submission Unit Type (Qualitative Concept)\tTotal MSAS Score (Intellectual Product)", + "output": "Regulatory Submission Unit Type (Qualitative Concept)" + }, + { + "input": "Definition: something described as sharply defined group of nerve cell bodies in the anterior hypothalamic region immediately above the lateral part of the optic chiasm; many of its cells are neurosecretory in function, secreting antidiuretic hormone; other cells are osmoreceptors.\nConcepts: PYTESTCD (Intellectual Product)\tVariant GM2-Gangliosidoses, AB (Gangliosidoses, GM2)\tcadmium-transporting ATPase activity (cadmium ion transmembrane transporter activity)\tsupraoptical nucleus (Magnocellular hypothalamic nuclei)\tCTCAE Grade 4 Myositis (Myositis, CTCAE 5.0)", + "output": "supraoptical nucleus (Magnocellular hypothalamic nuclei)" + }, + { + "input": "Definition: something described as monitors designed to measure various physiologic parameters associated with a patient's condition while the patient is being transported from one location to another (e.g., during interhospital or intrahospital transport). These monitors typically include capabilities for monitoring of electrocardiogram, hemoglobin oxygen saturation percentage, noninvasive blood pressure, and respiratory rate values; other monitoring capabilities (e.g., cardiac output, invasive blood pressure, intracranial blood pressure, end-tidal carbon dioxide) may also be included. Transport monitors are typically small, lightweight, and battery powered; intrahospital devices should be able to operate for several hours on battery power. Transport monitors may include configured, configured/modular, or modular designs.\nConcepts: CLASSICAL PHILOL (Intellectual Product)\tAnal Membrane (Embryonic Structure)\tGrade 3 Corneal infection (Corneal Infection, CTCAE)\tTransport Monitors (Medical Device)\t19: 46914377-46925686 (Spatial Concept)", + "output": "Transport Monitors (Medical Device)" + }, + { + "input": "Definition: Package Type described as container for semi-solid pharmaceutical forms, usually multidose, consisting of collapsible material intended to release the contents via a nozzle by squeezing the package.\nConcepts: Sick sinus syndrome (Cardiac Disorders, CTCAE)\tAnn Arbor Stage IIIE and IIIS (Ann Arbor lymphoma staging system)\tInhibitors, Phosphodiesterase 3 (Phosphodiesterase Inhibitors)\tTube (Medical Device)\tMedical Device Incompatibility Problem (Finding)", + "output": "Tube (Medical Device)" + }, + { + "input": "Definition: Perinatology described as a subspecialty of Pediatrics concerned with the newborn infant.\nConcepts: pregnancy circulation disorder (Disorder of pregnancy)\tMicrobial Liquid Culture (Culturing, In Vitro Microbial)\tNEONATOL (Pediatrics)\t11q22-q23 (Cell Component)\tStage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor (Neoplastic Process)", + "output": "NEONATOL (Pediatrics)" + }, + { + "input": "Definition: Biological Processes described as any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.\nConcepts: OMLAT (With laterality)\tregulation (biological control)\tVirulence (General Qualifier)\tAbnormality of inferior alveolar nerve (Abnormality of peripheral nerves)\tTherapeutic Skin Surgery (Therapeutic or Preventive Procedure)", + "output": "regulation (biological control)" + }, + { + "input": "Definition: something described as human EIF2S1 wild-type allele is located in the vicinity of 14q21.3 and is approximately 27 kb in length. This allele, which encodes eukaryotic translation initiation factor 2 subunit 1 protein, is involved in the initiation of protein translation.\nConcepts: Stage IIIB Uterine Corpus Leiomyosarcoma (Stage III Uterine Corpus Leiomyosarcoma AJCC v8)\tmultiparametric MRI (Diagnostic Procedure)\tEIF2 (Gene or Genome)\t-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)\tnicotinate nucleotide metabolic process (pyridine nucleotide metabolic process)", + "output": "EIF2 (Gene or Genome)" + }, + { + "input": "Definition: Cell Cycle Regulation Pathway described as the focus of this pathway is to illustrate the role of Polo-like Kinase 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorylation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3, like Chk1 and Chk2, also phosphorylates Cdc25C on serine-216 contributing to cell cycle arrest. Additionally they found that Plk3 also phosphorylates p53 on serine 20, a step that is stimulatory in the process leading up to p53-mediated apoptosis. Wang Q et al. found that Plk3 is closely associated with the centrosome and that this is dependent on the integrity of the microtubules. Expression of constitutively active or defective Plk3 kinase had significant defects on the shape and nature of the microtubule apparatus of the cell. In either case cell cycle progression was halted and apoptosis occurred.\nConcepts: Acquired monoclonal immunoglobulin light chain-associated Fanconi syndrome (Disease or Syndrome)\tHUMIDIFIER, NON-DIRECT PATIENT INTERFACE (Medical Device)\tFocal impaired awareness cognitive seizure with deja vu/jamais vu (Focal cognitive seizure with deja vu/jamais vu)\tCell Cycle Progression Pathway (Cell Function)\taccessory trigeminal nucleus (Body Part, Organ, or Organ Component)", + "output": "Cell Cycle Progression Pathway (Cell Function)" + }, + { + "input": "Definition: Orbital region described as smooth muscle layer located at the back of orbit where it spans the inferior orbital fissure.\nConcepts: EPHRIN RECEPTOR EphA4 (Receptor Tyrosine Kinase Gene)\tAcquired purpura fulminans (Disease or Syndrome)\tOrbitalis muscle (Muscle structure of orbit)\tNucleus motorius dissipatus formationis reticularis (Body Part, Organ, or Organ Component)\tSynovial tendon sheath of tibialis anterior (Synovial tendon sheath of foot)", + "output": "Orbitalis muscle (Muscle structure of orbit)" + }, + { + "input": "Definition: Diffuse large B-cell lymphoma of central nervous system described as the reemergence of primary diffuse large B-cell lymphoma of the central nervous system after a period of remission.\nConcepts: zinc II ion plasma membrane import (inorganic cation import across plasma membrane)\tRecurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System (Diffuse large B-cell lymphoma recurrent)\tERT - Total Negative Stimuli Administered (ERT Functional Test Question)\tUndesired Sedation Score 10 (Undesired Sedation Scale)\tploidy (Quantitative Concept)", + "output": "Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System (Diffuse large B-cell lymphoma recurrent)" + }, + { + "input": "Definition: something described as liquid sterile preparation consisting of an aqueous solution of electrolytes typically at a concentration close to the intracellular electrolyte composition, intended for storage, protection and/or perfusion of mammalian body organs that are in particular destined for transplantation.\nConcepts: aminoglycoside 3''-adenylyltransferase activity (aminoglycoside nucleotidyltransferase activity)\tDecreased ADOCBL (Abnormal vitamin B12 level)\tOrgan preservation solution (Biomedical or Dental Material)\tFilling, Nonsterile, Liquid, Pressure (Laboratory Procedure)\t17-allylamino-17-demethoxygeldanamycin hydroquinone (Pharmacologic Substance)", + "output": "Organ preservation solution (Biomedical or Dental Material)" + }, + { + "input": "Definition: regulation of striated muscle contraction described as any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle contraction.\nConcepts: negative regulation of striated muscle contraction (Organism Function)\tHDL3 (plasma lipoprotein particle)\tresponse to fenofibrate (response to organic cyclic compound)\tefflux pump complex location (transmembrane transporter complex)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Diabetes, Islet Cell Antibody (Medical Device)", + "output": "negative regulation of striated muscle contraction (Organism Function)" + }, + { + "input": "Definition: Streptococcus pneumoniae IgG Antibody Measurement described as a measurement of the Streptococcus pneumoniae serotype 14 IgG antibody in a biological specimen.\nConcepts: 8: 143958238-143952218 (Spatial Concept)\tStreptococcus pneumoniae Serotype 14 IgG Antibody (Streptococcus pneumoniae IgG Antibody Measurement)\tSpiritualism (Religious Philosophies)\tMicrowave Surgical Units, Scalpel (Medical Device)\tParachlamydiaceae Everett et al. 1999 (Parachlamydiales)", + "output": "Streptococcus pneumoniae Serotype 14 IgG Antibody (Streptococcus pneumoniae IgG Antibody Measurement)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as cognitive disorders characterized by an impaired ability to perceive the nature of objects or concepts through use of the sense organs. These include spatial neglect syndromes, where an individual does not attend to visual, auditory, or sensory stimuli presented from one side of the body.\nConcepts: Nucleotide Excision Repair Inhibition (Genetic Function)\tLife Support Care (Health Care Activity)\tDose Extravasation (Finding)\tPerivascular epithelioid cell tumour (Soft Tissue Tumor of Uncertain Differentiation)\tPERCEPTUAL DIS (Neurobehavioral Manifestations)", + "output": "PERCEPTUAL DIS (Neurobehavioral Manifestations)" + }, + { + "input": "Definition: Intellectual Product described as controlled Oral Word Association Test - Number correct words: Now I'm going to give you another letter, and again, say all words beginning with that letter that you can think of. You will have a minute for each one. The first letter is C.\nConcepts: HAQ02-Aid: Raised Toilet Seat (Intellectual Product)\tIncrease or decrease in fiber content of the diet. (Therapeutic or Preventive Procedure)\tCOWAT - Number Correct Words: C (COWAT Functional Test Question)\tRenal papillary necrosis caused by analgesic drug (Kidney Papillary Necrosis)\tFAC029-I Have a Lack of Energy (Intellectual Product)", + "output": "COWAT - Number Correct Words: C (COWAT Functional Test Question)" + }, + { + "input": "Definition: something described as specifies whether a change in the substance administration in relation to the previous substance administration is planned or not. EXAMPLE(S): True = planned, False = unplanned OTHER NAME(S): NOTE(S):\nConcepts: Performed Substance Administration Planned Change Indicator (Planned Change Indicator)\tKanuka Oil (Natural Products)\tAbnormality of threonine metabolism (Finding)\t3'GT (glucosyltransferase activity)\tTorulasporas (Saccharomycetales)", + "output": "Performed Substance Administration Planned Change Indicator (Planned Change Indicator)" + }, + { + "input": "Definition: Intermediary product of metabolism described as compounds of the type R-SO2-NHCONH-; when R=Ph, these are a group of hypoglycemic agents which enhance insulin secretion by beta cells and insulin sensitivity in target tissue, and so are effective in type II (noninsulin-dependent) diabetes mellitus.\nConcepts: Dopamine agonist agent (Drug groups primarily affecting the central nervous system)\tSulfonylureas (Intermediary product of metabolism)\tresection wedge (Surgical incisions)\tMetal, Alkaline Earth (Metals)\tLeft Testicular Artery (Body Part, Organ, or Organ Component)", + "output": "Sulfonylureas (Intermediary product of metabolism)" + }, + { + "input": "Definition: Finding described as moderate symptoms; limiting instrumental ADL\nConcepts: Grade 2 Vertigo, CTCAE (Finding)\tDizziness on lying flat (Positional Vertigo)\tDentinogenesis (Odontogenesis)\tresponse to isooctane (response to alkane)\tGrade 1 Pulmonary edema (Pulmonary Edema, CTCAE)", + "output": "Grade 2 Vertigo, CTCAE (Finding)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - Because of your health condition, in the past 30 days, how much difficulty did you have in: Getting all the work done that you need to do?\nConcepts: regulation of (R)-carnitine transmembrane transport (Cell Function)\tnormal skin (Observation of appearance of skin)\tNipple prosthesis, external (Prosthesis)\tT Cell-Directed CC Chemokine (beta-Chemokines)\tWD7-Getting All Work Done You Need (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)", + "output": "WD7-Getting All Work Done You Need (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: something described as human POU2F1 wild-type allele is located in the vicinity of 1q22-q23 and is approximately 206 kb in length. This allele, which encodes POU domain, class 2, transcription factor 1 protein, is involved in the modulation of transcription by RNA polymerase II.\nConcepts: Trigonum retromolare (Region of surface of bone organ)\tMachiavellianism (Personality)\tPOU Domain, Class 2, Transcription Factor 1 wt Allele (POU2F1 gene)\tTrauma Symptom Checklist for Children Questionnaire Test Name (Intellectual Product)\tIncreased vertebral height (Vertebral column)", + "output": "POU Domain, Class 2, Transcription Factor 1 wt Allele (POU2F1 gene)" + }, + { + "input": "Definition: Cell described as inducible regulatory T-lymphocytes that express CD4, CD25 (the alpha chain of the interleukin 2 receptor) and forkhead box P3 (FOXP3), with potential immunomodulating activity. Inducible CD4+CD25+ T regulatory cells (iTregs) are a subset of CD4+ T lymphocytes that are induced from CD25- precursors in peripheral lymphoid organs with interleukin-2 and transforming growth factor-beta. These regulatory T cells are essential in maintaining immunologic homeostasis. They may also prevent autoimmunity by suppressing self-reactive T cells, and may induce tolerance to allogeneic organ transplants such as in hematopoietic stem cell transplants.\nConcepts: Recombinant Interleukins (Recombinant Cytokines)\tsedimentation (Laboratory Procedure)\tinducible CD4+CD25+ regulatory T cells (Cell)\tStructure of piriform area (Olfactory Pathways)\tkitalase activity (beta-glucosidase activity)", + "output": "inducible CD4+CD25+ regulatory T cells (Cell)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the side of the body (or a paired organ) that is an access point for a procedure.\nConcepts: PerformedProcedure.approachAnatomicSiteLateralityCode (Approach Anatomic Site Laterality Code)\tOsteoporosis Susceptibility Gene Panel Reagents (Medical Device)\tPseudo-gout (Metabolic Bone Disorder)\tDefined Green Tea Catechin Extract OIntment (Clinical Drug)\tEC1456 (Pharmacologic Substance)", + "output": "PerformedProcedure.approachAnatomicSiteLateralityCode (Approach Anatomic Site Laterality Code)" + }, + { + "input": "Definition: CEP43 gene described as human FGFR1OP wild-type allele is located within 6q27 and is approximately 41 kb in length. This allele, which encodes FGFR1 oncogene partner protein, plays a role in anchoring microtubules to the centrosome. Translocation of the FGFR10P gene is associated with certain myeloproliferative disorders.\nConcepts: FGFR1 Oncogene Partner wt Allele (Gene or Genome)\tDifficult to breathe (Symptoms)\tDialysis Services and Procedures (office and lab procedure)\tUS Recommended Intake (Conceptual Entity)\tLL-37 (Amino Acid, Peptide, or Protein)", + "output": "FGFR1 Oncogene Partner wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire - Short Form - Taking everything into consideration, during the past week how satisfied have you been with your: Living/housing situation?\nConcepts: leucine zipper (Amino Acid, Peptide, or Protein)\tKawashima tsuji syndrome (Hereditary disorder of nervous system)\tQLES2-Living/Housing Situation (Intellectual Product)\tHaemophilus parahaemolyticus, Beta-Lactamase Negative (Bacterium)\tGlioblastoma multiforme (High Grade Astrocytic Tumor)", + "output": "QLES2-Living/Housing Situation (Intellectual Product)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the reason why an individual did not wash dishes.\nConcepts: Adoptive Cell Transfer Agent (Biological Response Modifiers)\tAugmented Cream Dosage Form (Cream)\tdown-regulation of pharyngeal pumping (negative regulation of eating behavior)\tHyperkinesia (nervous system disorder)\tDid Not Wash Dishes (Clinical or Research Assessment Question)", + "output": "Did Not Wash Dishes (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Laboratory Procedure described as cloning and characterization of viral vectors using producer cell lines or by transient production using plasmids.\nConcepts: Banking, Viral Vectors (Preparation)\tregulation of sequestering of zinc ion (regulation of cellular localization)\tPast Seven Days Frequency of Feeling Urge to Urinate All of a Sudden (Clinical or Research Assessment Question)\tPDGF-Receptor Beta-Like Tumor Suppressor (Biologically Active Substance)\tC147277 (Immunologic Tests)", + "output": "Banking, Viral Vectors (Preparation)" + }, + { + "input": "Definition: collagen binding described as interacting selectively and non-covalently with a type V collagen trimer.\nConcepts: Claims, Moral (Idea or Concept)\tFAMILY TARSIIDAE (Primates)\tBA (Southeastern Europe)\tRenal Afferent Vessel (Kidney part)\tcollagen V binding (Molecular Function)", + "output": "collagen V binding (Molecular Function)" + }, + { + "input": "Definition: something described as laryngeal cancer with no metastasis to regional lymph nodes.\nConcepts: Malig melanoma in preca melais (Nevus AND/OR melanoma)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Celiac Disease, Antigliadin Antibody (Medical Device)\tAnnotated Tissue (Intellectual Product)\tLaryngeal Cancer pN0 TNM Finding v8 (Laryngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tsite-specific DNA replication termination at RTS1 barrier (Genetic Function)", + "output": "Laryngeal Cancer pN0 TNM Finding v8 (Laryngeal Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radioimmunoconjugate consisting of murine monoclonal antibody (M195) and bismuth 213 (Bi213). Monoclonal antibody M195 binds to CD33, a surface antigen expressed by myelogenous leukemia cells. Bismuth 213 is an isotope that emits short-ranged high-energy alpha particles. This radioimmunoconjugate selectively delivers alpha particle-mediated cytotoxicity to leukemic cells, thereby limiting the exposure of normal tissues to ionizing radiation.\nConcepts: Washers, Laundry (Manufactured Object)\tThree tier interpretation model: Moderate risk (Finding)\tleukemia relapse (leukemia)\testablishment or maintenance of polarity of larval imaginal disc epithelium (establishment or maintenance of cell polarity)\tBi213 MOAB M195 (Pharmacologic Substance)", + "output": "Bi213 MOAB M195 (Pharmacologic Substance)" + }, + { + "input": "Definition: Pigmentation changes NEC described as disorders of pigmentation of the skin and other organs, including discoloration, hyperpigmentation and hypopigmentation.\nConcepts: nmol/l/(mg/m2) (Quantitative Concept)\tPigmentation disorder NOS (Pigmentation Disorders)\tEGFR NP 005219.2:p.Asp770 Asn771insSerValPro (Cell or Molecular Dysfunction)\tCognitive deficits (Hyperchloremia Severity)\tregulation of microglial cell mediated cytotoxicity (Cell Function)", + "output": "Pigmentation disorder NOS (Pigmentation Disorders)" + }, + { + "input": "Definition: modulation of spore germination on or near host described as any process that modulates the frequency, rate or extent of encysted zoospore germination on or near host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: HAMDS1-Psychic Anxiety (HAM-D6 Self-Report Version Questionnaire Question)\tmodulation of encysted zoospore germination on or near host (Biologic Function)\tExcision-Repair, Complementing Defective, In Chinese Hamster, 3 Gene (Gene or Genome)\tPulmonary Vascular Disorder (Vascular pulmonary disorders NEC)\tApplication site (Acquired body structure)", + "output": "modulation of encysted zoospore germination on or near host (Biologic Function)" + }, + { + "input": "Definition: regulation of protein linear polyubiquitination described as any process that stops, prevents or reduces the frequency, rate or extent of protein linear polyubiquitination.\nConcepts: negative regulation of protein linear polyubiquitination (negative regulation of protein polyubiquitination)\tHigh Risk (Intellectual Product)\tPubertal stage (Temporal Concept)\tInterparietal fissure (Sulcus of brain)\tAllergic reaction NOS (Disorder of blood / lymphatics / immune system)", + "output": "negative regulation of protein linear polyubiquitination (negative regulation of protein polyubiquitination)" + }, + { + "input": "Definition: Immediate hypersensitivity described as asthmatic adverse reaction (e.g., BRONCHOCONSTRICTION) to conventional NSAIDS including aspirin use.\nConcepts: blood vessel endothelial cell proliferation involved in sprouting angiogenesis (Cell Function)\tSyndromes, Aspirin-Induced Asthma (Adverse reaction to antiplatelet agent)\t3-beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase activity (Molecular Function)\tLancing Devices, Blood (Medical Device)\tammonia:ferredoxin oxidoreductase activity (Molecular Function)", + "output": "Syndromes, Aspirin-Induced Asthma (Adverse reaction to antiplatelet agent)" + }, + { + "input": "Definition: something described as no tumor in either eye is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea.\nConcepts: Thermoanaerobacterium Lee et al. 1993 emend. Cann et al. 2001 (Thermoanaerobacterium)\tLeukoencephalopathy (Nervous System Disorders, CTCAE)\tCissampelo (Cissampelideae)\tRetinoblastoma cT1a TNM Finding v7 (Retinoblastoma cT1 TNM Finding v7)\tHydroxypyruvate Reductase (Oxidoreductase)", + "output": "Retinoblastoma cT1a TNM Finding v7 (Retinoblastoma cT1 TNM Finding v7)" + }, + { + "input": "Definition: carbohydrate derivative binding described as interacting selectively and non-covalently with ascr#2.\nConcepts: Limited Quality (Image Quality)\tascr#2 binding (carbohydrate derivative binding)\tBiologic Dressings (Bandage)\tDNA, Z-Form (Nucleic Acid Conformation)\tdownregulation of chromosome condensation (negative regulation of chromosome organization)", + "output": "ascr#2 binding (carbohydrate derivative binding)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a number of different mechanisms of action. In vivo, fluoruracil is converted to the active metabolite 5-fluoroxyuridine monophosphate (F-UMP); replacing uracil, F-UMP incorporates into RNA and inhibits RNA processing, thereby inhibiting cell growth. Another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase, resulting in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in the in vivo synthesis of DNA. Other fluorouracil metabolites incorporate into both RNA and DNA; incorporation into RNA results in major effects on both RNA processing and functions.\nConcepts: Mid Cells (Blood Cell Count Ratio Measurement)\tVUS BRCA (DNA Repair Gene Mutation)\tGrowth Factor Gene (Genes)\t2,4(1H,3H)-Pyrimidinedione, 5-fluoro- (F [Preparations])\tRights of Indigenous Peoples (Regulation or Law)", + "output": "2,4(1H,3H)-Pyrimidinedione, 5-fluoro- (F [Preparations])" + }, + { + "input": "Definition: WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Your day-to-day work/school?\nConcepts: Taenia coli (Muscle layer of large intestine)\tFatty Acid Binding Protein 1 (Laboratory Procedure)\tWD1-Your Day-to-Day Work/School (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)\ttransformations (Cell Function)\tGERP95 (AGO1 gene)", + "output": "WD1-Your Day-to-Day Work/School (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: something described as fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit.\nConcepts: fusion of viral membrane with host outer nuclear membrane involved in nuclear egress (multi-organism membrane fusion)\tChemokine STCP-1, CC (beta-Chemokines)\tsucrose:2,1-beta-D-fructan 1-beta-D-fructosyltransferase activity (hexosyltransferase activity)\tdisease heart pulmonary (Respiratory System Disorders, General, Functional and NEC)\tIC95 Fold Change from Baseline (Inhibitory Concentration Test)", + "output": "fusion of viral membrane with host outer nuclear membrane involved in nuclear egress (multi-organism membrane fusion)" + }, + { + "input": "Definition: Cell described as a preparation of human CD8-positive tumor-specific T lymphocytes engineered to express the natural killer cell activating receptor group 2D (NKG2D) and the serine/threonine kinase AKT, with potential immunomodulating and antineoplastic activities. Upon administration of CD8+NKG2D+ AKT cells, these cells target and kill tumor cells. AKT-mediated signaling enhances the activation, differentiation, proliferation and cytokine production of tumor specific T cells, which enhances their anti-tumor effects; AKT activity in T cells is often downregulated in the tumor environment. NKG2D, a stimulatory lymphocyte receptor, mediates the recognition of tumors cells and promotes T-cell activation and T-cell-mediated tumor cell killing; NKG2D ligands are expressed on cancer cells, while they are minimally expressed by or absent from normal, healthy cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C132027\" active clinical trials using this agent.\nConcepts: WD2-Washing His/Her Whole Body (Intellectual Product)\tPUL 1.2 - Shoulder Flexion to Height (Intellectual Product)\tgondoic acid (Organic Chemical)\tchromosome 22 monosomy syndrome (Monosomy and deletion from autosome)\tNKG2D/AKT-expressing CD8-positive T-cells (Antineoplastic Immune Cell)", + "output": "NKG2D/AKT-expressing CD8-positive T-cells (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glycerol 1,2-cyclic phosphate + H(2)O = glycerol 1-phosphate + H(+).\nConcepts: Thrombocytopaenia (Purpura and other hemorrhagic conditions)\trac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity (Molecular Function)\tGrade 2 Pharyngolaryngeal pain (Finding)\tIVD Panels, Human Genetics, Pulmonary Disorder, Fibrosis/Hermansky-Pudlak Syndrome, Del/Dup (IVD Panels, Human Genetics, Pulmonary Disorder, Fibrosis/Hermansky-Pudlak Syndrome)\tendocardial cell differentiation (Cell Function)", + "output": "rac-glycerol 1:2-cyclic phosphate 2-phosphodiesterase activity (Molecular Function)" + }, + { + "input": "Definition: Renal clearance diagnostic test described as the clearance of a substance from the blood by the kidneys divided by the body mass index.\nConcepts: Extracellular matrix proteins (Scleroproteins)\tRENALCLB (Renal clearance diagnostic test)\thomeo box A5 (HOXA@ gene cluster)\tPriority of Disease Contact (Intellectual Product)\tReduced muscle fibre emerin (Finding)", + "output": "RENALCLB (Renal clearance diagnostic test)" + }, + { + "input": "Definition: Cerebrovascular Disorders described as blockage of the central retinal artery.\nConcepts: occlusion of central retinal artery (Retinal Artery Occlusion)\tCAMK2B wt Allele (CAMK2B gene)\tTTYPE (CDISC Protocol Terminology)\tspeechreading (Language Arts)\tCartoon as Topics (Caricatures as Topic)", + "output": "occlusion of central retinal artery (Retinal Artery Occlusion)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport.\nConcepts: FAC062-I Have Emotional Ups and Downs (Intellectual Product)\tchaperone protein binding (Protein Binding)\tregulation of planar cell polarity pathway involved in ventricular septum morphogenesis (Cell Function)\tGrade 4 Respiratory failure (Finding)\ttrial design element (Study Element)", + "output": "chaperone protein binding (Protein Binding)" + }, + { + "input": "Definition: Medical Device described as metal devices for fastening together two or more parts of dental prostheses for stabilizing or retaining them by attachment to abutment teeth. For a precision attachment for a partial denture DENTURE PRECISION ATTACHMENT is available.\nConcepts: Labour (Female genital tract functions)\tmannose 6 phosphate (Sugar Phosphates)\tPROSTHESIS, KNEE, PATELLOFEMOROTIBIAL, SEMI-CONSTRAINED, METAL/POLYMER, MOBILE BEARING (Medical Device)\tbacterial CNS infection (Bacterial infection of the nervous system)\tClasps, Dental (Dentures)", + "output": "Clasps, Dental (Dentures)" + }, + { + "input": "Definition: Immunologic Factor described as a cell-based cancer vaccine consisting of hybrid cells created by electrofusing autologous dendritic cells (DCs) and allogeneic lymphoma cells with potential immunostimulating and antitumor activities. Upon administration, autologous lymphoma cell/allogeneic dendritic cell electrofusion hybrid vaccine may stimulate the immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against specific autologous lymphoma-associated antigens, resulting in lymphoma cell apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85451\" active clinical trials using this agent.\nConcepts: regulation of single strand break repair (Genetic Function)\tPerigraft Leak (Postoperative Hemorrhage)\tautologous lymphoma cell/allogeneic dendritic cell electrofusion hybrid vaccine (Dendritic Cell Vaccine)\tblood administration set MISCELL EACH (Device set)\tMALDIVIAN (Asians)", + "output": "autologous lymphoma cell/allogeneic dendritic cell electrofusion hybrid vaccine (Dendritic Cell Vaccine)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Severe human suffering: Part of my job.\nConcepts: period effect (Effect)\tLEC0113D (LEC-5 Standard Version Questionnaire Question)\tStage I Hypopharyngeal Throat Cancer (Hypopharyngeal Carcinoma by AJCC v7 Stage)\tTSCYC1-Being Easily Scared (TSCYC Questionnaire Question)\tParticipating Organization (Organization)", + "output": "LEC0113D (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Skin Manifestations described as skin lumpiness or skin surface dimpling often seen on the thighs, buttocks and abdomen. It is due to protrusion of SUBCUTANEOUS FAT into the DERMIS layer of skin.\nConcepts: lysosomal proteolysis associated with antigen processing and presentation (Molecular Function)\tMental Retardation, Non-Syndromic, Autosomal Recessive, 21 Gene (Gene or Genome)\tPODCI386 (Intellectual Product)\tCellulite (Skin dimple)\tReportVersion.physicianSignOffIndicator (Physician Sign Off Indicator)", + "output": "Cellulite (Skin dimple)" + }, + { + "input": "Definition: something described as survival motor neuron protein (294 aa, ~32 kDa) is encoded by the human SMN1 and SMN2 genes. This protein plays a role in the assembly of small nuclear ribonucleoproteins.\nConcepts: Body of the Penis (penis)\tSurvival Motor Neuron Protein (Biologically Active Substance)\tregulation of protein export from cell nucleus (regulation of intracellular protein transport)\tall-trans-retinol binding (Molecular Function)\tMelanoma of the Uvea Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)", + "output": "Survival Motor Neuron Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as lectins purified from the germinating seeds of common wheat (Triticum vulgare); these bind to certain carbohydrate moieties on cell surface glycoproteins and are used to identify certain cell populations and inhibit or promote some immunological or physiological activities. There are at least two isoforms of this lectin.\nConcepts: Cyst, Schizencephalic (Congenital anomaly of head)\tWheat Germ Agglutinins (Amino Acid, Peptide, or Protein)\tMale Gender, Self Reported (Qualitative Concept)\tGLUTAMATE RECEPTOR, METABOTROPIC, 3 (Gene or Genome)\tarea paAr of Pandya-1973 (Body Location or Region)", + "output": "Wheat Germ Agglutinins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Neoplastic Process described as the reemergence of submandibular gland squamous cell carcinoma after a period of remission.\nConcepts: Recurrent Submandibular Gland Squamous Cell Carcinoma (Recurrent Head and Neck Squamous Cell Carcinoma)\tDHS (Auditory system hereditary disorder)\tNADPH-dependent curcumin reductase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\teswl (Destructive procedure)\tAbnormality of the coccyx (Anatomical Abnormality)", + "output": "Recurrent Submandibular Gland Squamous Cell Carcinoma (Recurrent Head and Neck Squamous Cell Carcinoma)" + }, + { + "input": "Definition: Organic Chemical described as the V-series nerve agent VS.\nConcepts: response to butan-1-ol (response to alcohol)\tVS (Organic Chemical)\tAdenoiditis (Upper respiratory tract infections NEC)\tC20orf139 (Gene or Genome)\tCAMPYLOBACTER PYLORI (Indicator, Reagent, or Diagnostic Aid)", + "output": "VS (Organic Chemical)" + }, + { + "input": "Definition: Lipid Metabolism Disorders described as a rare, fatal, autosomal recessive lipid storage disorder caused by mutations in the HEXA gene. It is characterized by deficiency of beta-hexosaminidase A, resulting in accumulation of gangliosides in the neurons of the brain and spinal cord. Signs and symptoms include progressive deterioration of the mental and physical abilities early in life, accompanied by blindness, deafness, muscle atrophy, and paralysis.\nConcepts: myosin filament disassembly (Molecular Function)\tAdrenal-Neuroendocrine Tumor pT1 TNM Finding v8 (Finding)\tRET Rearrangement Analysis Testing Method (Specify Molecular Abnormality Analysis Method)\tTay-Sachs (Lysosomal Storage Diseases)\tPKCM (Gene or Genome)", + "output": "Tay-Sachs (Lysosomal Storage Diseases)" + }, + { + "input": "Definition: something described as this gene is involved in cell-cell signaling.\nConcepts: Htk-L (Ligand Binding Protein Gene)\tposterior auditory area (Auditory area)\tL-serine hydro-lyase (Molecular Function)\thistone demethylation (histone modification)\tHerpes Simplex Virus 1/2 IgG Antibody Measurement (Immunologic Tests)", + "output": "Htk-L (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: neural nucleus development described as the progression of the retrotrapezoid nucleus (RTN) over time from it's initial formation to its mature state. The retrotrapezoid nucleus is a group of neurons in the rostral medulla, which are responsible regulating respiration.\nConcepts: Non-Hereditary Lesion (Finding)\tPLK3 wt Allele (Gene or Genome)\topaque (Appearance)\tretrotrapezoid nucleus development (neural nucleus development)\t49 UNCLASSIFIED FUNGI (Fungi)", + "output": "retrotrapezoid nucleus development (neural nucleus development)" + }, + { + "input": "Definition: Gene or Genome described as human DIS3 wild-type allele is located in the vicinity of 13q22.1 and is approximately 27 kb in length. This allele, which encodes exosome complex exonuclease RRP44 protein, plays a role in the modulation of ribosomal RNA processing.\nConcepts: Type B2 (Classification)\tProsthetic Valve Thrombosis (Thrombosis)\tAcanthomas, Pilar Sheath (Benign tumor of skin with pilar differentiation)\tMRImagingAcquisitionProtocolElement.multipleSpinEchoIndicator (Functional Concept)\tdis3p (DIS3 gene)", + "output": "dis3p (DIS3 gene)" + }, + { + "input": "Definition: Anomalous coronary artery arising from the opposite sinus described as origin of the right coronary artery (RCA) from the left sinus of Valsalva or of the left main (LM) or left anterior descending (LAD) coronary artery from the right sinus of Valsalva, with the additional feature that the artery passes between the two great arteries. This carries a risk of the artery being compressed by these two vessels,\nConcepts: Coronary artery sandwich anomaly (Anomalous coronary artery arising from the opposite sinus)\tN-terminal protein formylation (protein formylation)\tPopulation, Suburban (geographic population)\tradiopharmacology (Biomedical Occupation or Discipline)\tSIQR - Memory Problems (SIQR Questionnaire Question)", + "output": "Coronary artery sandwich anomaly (Anomalous coronary artery arising from the opposite sinus)" + }, + { + "input": "Definition: something described as a Cremophor EL-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of the solvent Cremophor, thereby permitting the administration of larger doses of paclitaxel while avoiding the toxic effects associated with Cremophor.\nConcepts: co-transcriptional gene silencing by RNA interference machinery (gene silencing by RNA)\tintegral component of postsynaptic endocytic zone membrane (Cell Component)\tbuffers (chemicals subcategory)\tnab paclitaxel (paclitaxel)\tAbsolute Bioavailability (Quantitative Concept)", + "output": "nab paclitaxel (paclitaxel)" + }, + { + "input": "Definition: something described as not occurring regularly or at short intervals.\nConcepts: Intratubular calcium phosphate casts (Finding)\tOccasional (Frequencies)\tSafeties, Patient (Category II Codes)\tSomatic Hypermutator Phenotype (Organism Attribute)\tCervical Carcinoma Clinical TNM Finding v8 (Cervical Cancer TNM Finding v8)", + "output": "Occasional (Frequencies)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cyclin-dependent kinase 10 (360 aa, ~41 kDa) is encoded by the human CDK10 gene. This protein plays a role in cell cycle regulation and protein phosphorylation.\nConcepts: Stage I Gastric Neuroendocrine Tumor (Neoplastic Process)\tBlastoderm (Embryo, Nonmammalian)\tEC 2.7.1.11 (Enzyme)\tAdT (protein-containing complex)\tregulation of GTP binding (Molecular Function)", + "output": "EC 2.7.1.11 (Enzyme)" + }, + { + "input": "Definition: something described as a gel-based formulation composed of a very dilute solution of hydrogen peroxide (H2O2) combined with hyaluronic acid (HA), with potential radiosensitizing activity. Upon intratumoral injection and slow-release (SR) of H2O2 from the gel, H2O2 releases oxygen and inactivates anti-oxidative enzymes, thereby increasing the oxygen concentration in the tumor environment, which increases the efficacy of radiotherapeutic treatment. HA increases viscosity of the formulation and allows for the SR of H2O2; as compared to the injection of H2O2 alone, the addition of HA decreases diffusion of H2O2 to surrounding areas and enhances intratumoral H2O2 concentration over an increased period of time. Hypoxic tumors show a decreased response to radiotherapy; thus, increasing oxygen content increases tumor response to radiotherapy.\nConcepts: Epidermolysis Bullosa, Junctional, Non-Herlitz Type (Hereditary Connective Tissue Disorder)\tMyosin Light Chain 3 Measurement (Laboratory Procedure)\tCongenital Phrenic Nerve Palsy (Phrenic nerve paralysis)\tsupercomputer (computer system hardware)\tHydrogen Peroxide-hyaluronic Acid Intratumoral Injectable Formulation (Pharmacologic Substance)", + "output": "Hydrogen Peroxide-hyaluronic Acid Intratumoral Injectable Formulation (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as providing a client/patient with labor and delivery care when she has chosen to have a water birth in an out-of-hospital setting. Service is billed per delivery.\nConcepts: regulation of mesenchymal cell proliferation involved in prostate gland development (regulation of reproductive process)\tRx (Document type)\tCervical Mixed Epithelial and Mesenchymal Neoplasm (Neoplastic Process)\tCD4-positive, alpha-beta T cell proliferation (alpha-beta T cell proliferation)\tH2O brth Xhosp ea.dlvry (Obstetric Delivery)", + "output": "H2O brth Xhosp ea.dlvry (Obstetric Delivery)" + }, + { + "input": "Definition: something described as stage I breast cancer is divided into stages IA and IB. In stage IA, the tumor is 2 centimeters or smaller and has not spread outside the breast.\nConcepts: vesicle endocytosis (membrane activity)\tstage IA breast cancer (Neoplastic Process)\tpyridine-3,4-diol dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tPAKISTANI (Population Group)\ttoluene catabolism (drug catabolic process)", + "output": "stage IA breast cancer (Neoplastic Process)" + }, + { + "input": "Definition: Biospecimen described as a specimen that is mounted for microscopic study following preparation methods which use dyes, reagents, or other materials to produce coloration of cellular structures.\nConcepts: Lymphotoxin Beta Gene (LTB gene)\tMyeloid and Lymphoid Neoplasms with PDGFRB Rearrangement (Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2)\tStained Specimen (Biospecimen)\tKeratoderma palmoplantar, with deafness (Hereditary palmoplantar keratoderma)\tantibody Dengue virus (Antibody studies)", + "output": "Stained Specimen (Biospecimen)" + }, + { + "input": "Definition: something described as gan jiang\nConcepts: synaptobrevin 2-SNAP-25-syntaxin-2 complex (Cell Component)\tPR0105 (PR Questionnaire Question)\tMalig melanoma of soft tissue (Neoplastic Process)\tZingiberis siccatum / gan jiang (Plant)\tDisplays (Functional Concept)", + "output": "Zingiberis siccatum / gan jiang (Plant)" + }, + { + "input": "Definition: Geographic Area described as the geographical area of Africa comprising ALGERIA; EGYPT; LIBYA; MOROCCO and TUNISIA. It includes also the vast deserts and oases of the Sahara. It is often referred to as North Africa or the Maghreb.\nConcepts: Africa, Northern (Geographic Area)\tSex chromosome (Cell Component)\tPKA C-Beta (Amino Acid, Peptide, or Protein)\tStage IA3 (Stage 1A)\tpositive regulation of (PG)H synthase activity (Molecular Function)", + "output": "Africa, Northern (Geographic Area)" + }, + { + "input": "Definition: therapeutic autologous dendritic cells described as a therapeutic melanoma vaccine consisting of autologous dendritic cells (DCs) pulsed with antigens from lethally irradiated autologous tumor cells derived from a patient-specific, continuously proliferating and melanoma-initiating cell line and suspended in a solution containing the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon subcutaneous administration, melapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the patient's repertoire of melanoma-associated antigens, particularly tumor stem cell antigens, found in the irradiated autologous cancer cells. As an immunostimulant, GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes.\nConcepts: Curets (Surgical Instruments)\tPerson (UML Entity)\tMelapuldencel-T (therapeutic autologous dendritic cells)\tCell, Hepatic Stellate (Cells)\tinterferon alfa-2a,recomb. (Pharmacologic Substance)", + "output": "Melapuldencel-T (therapeutic autologous dendritic cells)" + }, + { + "input": "Definition: something described as a ubiquitously-expressed claudin subtype that acts as a general barrier-forming protein in TIGHT JUNCTIONS. Elevated expression of claudin-3 is found in a variety of tumor cell types, suggesting its role as a therapeutic target for specific ANTINEOPLASTIC AGENTS.\nConcepts: 17q21.3-q22.1 (Cell Component)\tIntrapartum Process (Period)\tCYP2D6*6 (CYP2D6 gene)\tstage IV adult Burkitt lymphoma (Stage IV Burkitt Lymphoma)\tclaudin 3 (Amino Acid, Peptide, or Protein)", + "output": "claudin 3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as brief Pain Inventory - Other methods I use to relieve pain include: distraction.\nConcepts: Fusion Gene (Gene or Genome)\tBPI1-Distraction to Relieve Pain (BPI Questionnaire Question)\tTUBE, BRONCHIAL (biomedical tube device)\tLugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 (Lugano Classification Hodgkin Lymphoma by AJCC v8 Stage)\tNasal cartilage loss (Ear, nose and throat finding)", + "output": "BPI1-Distraction to Relieve Pain (BPI Questionnaire Question)" + }, + { + "input": "Definition: Language described as a group of languages spoken in the northwestern Caucasus region, chiefly in three Russian republics (Adygea, Kabardino-Balkaria, Karachay-Cherkessia), the territory of Abkhazia, and Turkey, with smaller communities scattered throughout the Middle East.\nConcepts: ATOMIC ABSORPTION, CALCIUM (Medical Device)\tSacral spinal cord (Spinal cord part)\tWest Caucasian (Language)\tTechnic, Delphi (Research Activity)\tDecreased casein diet (Diet modified for specific foods or ingredients)", + "output": "West Caucasian (Language)" + }, + { + "input": "Definition: Anomaly of eye described as ring dermoid of cornea has characteristics of annular limbal dermoids (growths with a skin-like structure) with corneal and conjunctival extension. Less than 30 cases have been described. Transmission is autosomal dominant and mutations in the PITX2 gene on chromosome 4q25 have been suggested as a potential cause of the condition.\nConcepts: RING DERMOID OF CORNEA (Mass of cornea)\tAVL01-List A 30 Min Delay Recall Total (Intellectual Product)\tSWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 2 wt Allele (SMARCC2 gene)\tPHOTOREFRACTOR (Medical Device)\tFerrum sulphuricum / iron sulphate (Inorganic Chemical)", + "output": "RING DERMOID OF CORNEA (Mass of cornea)" + }, + { + "input": "Definition: RNA Recognition Motif described as an RNA-binding motif characterized by an alpha-beta-beta-beta-alpha fold that binds DOUBLE-STRANDED RNA. It occurs in many eukaryotic proteins as well as in bacterial and viral proteins.\nConcepts: Choledochoscopes, Laparoscopic (Medical Device)\tDouble-Stranded RNA Binding Domain (RNA-Binding Motifs)\tAcute Sinusitis (Korean Standard Classification of Disease Version 5)\ttranscription regulator complex location (Cell Component)\tFAC015-I Get Support From My Friends (FACT-HEP Version 4 Questionnaire Question)", + "output": "Double-Stranded RNA Binding Domain (RNA-Binding Motifs)" + }, + { + "input": "Definition: Geographic Area described as a country in northern Africa, bordering the Mediterranean Sea, between Algeria and Libya.\nConcepts: TUN (Geographic Area)\tmelanoma antigen family B18 (Gene or Genome)\tMAZINDOL (Heterocyclic Compounds)\tDelayed hypersensitivity skin test, multitest (Delayed hypersensitivity skin test)\tMGB1 Positive (Laboratory or Test Result)", + "output": "TUN (Geographic Area)" + }, + { + "input": "Definition: something described as a homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.\nConcepts: BET inhibitor FT-1101 (Organic Chemical)\toxygen homeostasis (Biologic Function)\tfrontal pole (Body Part, Organ, or Organ Component)\tTPM2 protein, human (Amino Acid, Peptide, or Protein)\tProcedure Kit/Trays, Irrigation/Lavage, Perineal (Procedure Kit/Trays, Irrigation/Lavage)", + "output": "oxygen homeostasis (Biologic Function)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - Since returning: I get along well with my family members.\nConcepts: DRRI1-P: I Get Along Well With My Family (Intellectual Product)\tzebra fish (Fishes)\tSynovial fluid WBC (Synovial Fluid: Other Laboratory Findings)\tNotch 2 Gene (Receptor Gene)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard for Family to Plan Activities (Intellectual Product)", + "output": "DRRI1-P: I Get Along Well With My Family (Intellectual Product)" + }, + { + "input": "Definition: Malignant neoplasm of gastrointestinal tract described as a primary or metastatic malignant neoplasm that affects the appendix. Representative examples include carcinoma and lymphoma.\nConcepts: Psychology, Perceptual (Biomedical Occupation or Discipline)\tHaemophilia Activities List (Intellectual Product)\tAbnormal blood Cl concentration (Finding)\tMalignant Tumor of Appendix (Malignant tumor of colon)\tErythroid Maturation Index (Laboratory Procedure)", + "output": "Malignant Tumor of Appendix (Malignant tumor of colon)" + }, + { + "input": "Definition: myosin II filament organization described as the disassembly of a bipolar filament composed of myosin II molecules.\nConcepts: toll like receptor 7 (Toll-Like Receptor Family Gene)\tmyosin II filament disassembly (myosin filament disassembly)\tFOAMY MYOCARDIAL TRANSFORMATION OF INFANCY (Disease or Syndrome)\t5'-Diphosphocholine, Cytidine (Other psychostimulants and nootropics in ATC)\tSupernatant (Specimen component)", + "output": "myosin II filament disassembly (myosin filament disassembly)" + }, + { + "input": "Definition: Form family Moniliaceae described as a species of zoophilic fungi in the phylum Ascomycota with a worldwide distribution and a wide range of animal hosts. This species causes inflammatory skin or scalp lesions in humans.\nConcepts: Acid, Nitric (Acids, Noncarboxylic)\tConcentrate for Solution for Intraocular Irrigation Dosage Form (Concentrated Solution Dosage Form)\tMicroides mentagrophytes (Fungus)\tTSP-1-mimetic Peptide ABT-510 (Amino Acid, Peptide, or Protein)\tGrade 4 Blood bilirubin increased (Finding)", + "output": "Microides mentagrophytes (Fungus)" + }, + { + "input": "Definition: something described as dehydration resulting from abnormally high levels of sodium in the blood. Infants and individuals that are intubated are at highest risk.\nConcepts: Familial Alzheimer's Disease, Type 1 (Disease or Syndrome)\tpost-embryonic root development (Organism Function)\tGestational Trophoblastic Tumor Pathologic Primary Tumor TNM Finding v7 (Finding)\tPerceptual Aftereffect (Illusions)\tHypernatremic dehydration (Finding)", + "output": "Hypernatremic dehydration (Finding)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.\nConcepts: 2: 27478096-27460374 (Spatial Concept)\tN-methylnicotinate transport (Cell Function)\tprotein localization to linear element (Cell Function)\ttraditional medicine (Complementary therapies)\tEnlarged heart right atrium (Right atrial abnormality)", + "output": "traditional medicine (Complementary therapies)" + }, + { + "input": "Definition: starch described as a starch consisting of exclusively alpha-D glucose monomers connected by a 1-4 bond.\nConcepts: Reference Result Target Anatomic Site Laterality Code (Target Anatomic Site Laterality Code)\tClark melanoma level (GENERAL LINKAGE/MODIFIERS)\tKbr, Ex and Mer complex location (protein-containing complex)\tValue Code Modified Text (Intellectual Product)\tamylose (Polysaccharides)", + "output": "amylose (Polysaccharides)" + }, + { + "input": "Definition: something described as a urodynamics measurement system is a device used to measure volume and pressure in the urinary bladder when it is filled through a catheter with carbon dioxide or water. The device controls the supply of carbon dioxide or water and may also record the electrical activity of the muscles associated with urination. The device system may include transducers, electronic signal conditioning and display equipment, a catheter withdrawal device to enable a urethral pressure profile to be obtained, and special catheters for urethral profilometry and electrodes for electromyography. This generic type of device includes the cystometric gas (carbon dioxide) device, the cystometric hydrualic device, and the electrical recording cystometer, but excludes any device that uses air to fill the bladder.\nConcepts: Loiases (Filariasis)\tPegylated Liposomal Irinotecan (Topoisomerase I Inhibitors)\tBlood Protein Disorders (Disease or Syndrome)\tCYSTOMETRIC GAS (CARBON-DIOXIDE) ON HYDRAULIC DEVICE (Medical Device)\tulna; hypoplasia (Limb structure)", + "output": "CYSTOMETRIC GAS (CARBON-DIOXIDE) ON HYDRAULIC DEVICE (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Sexual activities?\nConcepts: WHODAS 2.0 36-item Version Interviewer-administered - Sexual Activities (Intellectual Product)\tHuMV833 monoclonal antibody (Angiogenesis Activator Inhibitor)\tMeconium ileus due to guanylate cyclase 2C deficiency (Digestive system hereditary disorder)\tSWITZERLAND (Affiliate Realms)\tPhysiatry (Biomedical Occupation or Discipline)", + "output": "WHODAS 2.0 36-item Version Interviewer-administered - Sexual Activities (Intellectual Product)" + }, + { + "input": "Definition: Gel described as gel (e.g., carbohydrate polymer) designed to act as a temporary barrier inhibiting postsurgical adhesion between tissues and organs. This gel is applied to the surface of tissues and organs at the end of surgery, before surgical close, and is typically resorbed by the body in a short period (e.g., several days or weeks). Postsurgical adhesion inhibition gel is mostly used as an adhesion barrier following spinal surgery (e.g., laminectomy) or tendon and peipheral nerve surgery. Some adhesion inhibition gels are inteneded for use in pelvic, gynecological, abdominal, or implant surgery\nConcepts: Adhesion Barrier Gel (Gel)\tInjury, Ankle (Injury of free lower limb)\tMapping, Peptide (Chemistry, Analytic)\tMarigolds (Calenduleae)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MCOLN1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Adhesion Barrier Gel (Gel)" + }, + { + "input": "Definition: Surgical Clamps described as a vascular clamp is a surgical instrument used to occlude a blood vessel temporarily.\nConcepts: pleomorphic (Qualitative Concept)\tCSEPI (Laboratory Procedure)\tDefibrillation Threshold (Quantitative Concept)\tsulfur molecular entity transmembrane transporter activity (transmembrane transporter activity)\tVascular Surgery Clamps (Medical Device)", + "output": "Vascular Surgery Clamps (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an 85-amino acid recombinant peptide derived from protein c2 of the hemophagocytic hookworm Ancylostoma caninum (a common canine parasite) with anticoagulant activity. Recombinant nematode anticoagulant protein c2 (rNAPc2) binds to circulating activated factor X (FXa) or zymogen factor X (FX) to form a binary complex which subsequently binds to and inhibits membrane-bound activated factor VII/tissue factor complex (FVIIa/TF). When administered prophylactically, this agent may reduce the incidence of deep venous thrombosis without hemostatic compromise. Because rNAPc2 inhibits the formation of the FVIIa/TF protease complex, which may play a role in the cellular signaling of both metastatic and angiogenic processes, it may impede tumor progression. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C69129\" active clinical trials using this agent.\nConcepts: Autoimmune lymphoproliferative syndrome type IV (Immunodeficiency associated with chromosomal abnormality)\tmeiotic prophase II (Prophase)\tNegotiating (Interpersonal Relations)\trNAPc2 (Amino Acid, Peptide, or Protein)\tADCS-ADL Severe Dementia - Sum of Items 1-5 (Intellectual Product)", + "output": "rNAPc2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Young Child (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to turn him or herself during the night.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, UMOD (Medical Device)\tTransdermal Solution Dosage Form (Solution Dosage Form)\tclathrin-dependent endocytosis involved in vitellogenesis (Physiologic Function)\tcellular response to laminar fluid shear stress (response to laminar fluid shear stress)\tPQL17-Hard to Turn During Night (Intellectual Product)", + "output": "PQL17-Hard to Turn During Night (Intellectual Product)" + }, + { + "input": "Definition: something described as combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.\nConcepts: amino acid import (Cell Function)\tG protein-coupled bile acid receptor activity (bile acid receptor activity)\tFood Security (Qualitative Concept)\tClaus Model Lifetime Breast Cancer Risk Assessment (Assessment scales)\tE170 (Amino Acid, Peptide, or Protein)", + "output": "G protein-coupled bile acid receptor activity (bile acid receptor activity)" + }, + { + "input": "Definition: Occupational Activity described as monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the air; includes periodic or continuous surveillance or testing to determine the level of compliance with statutory requirements and/or pollutant levels in the air.\nConcepts: pyrimidine nucleoside diphosphate catabolic process (Molecular Function)\tAbuse Recovery (Detail of abuse)\t12 Lead Placement Mason Likar (Lead Placement)\tair sampling/monitoring (Occupational Activity)\tmethomyl (Insecticides)", + "output": "air sampling/monitoring (Occupational Activity)" + }, + { + "input": "Definition: Cell described as provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.\nConcepts: Tablet Container (Containers)\tOccasional Urinary Incontinence (Clinical or Research Assessment Answer)\tFe-S transferase activity (Molecular Function)\tEnglish, UK (Language)\tBG04 (Cell)", + "output": "BG04 (Cell)" + }, + { + "input": "Definition: Suction regulator described as suction regulators designed to provide a low airflow rate (usually under 0.3 lpm). These regulators typically allow vacuum levels between 40 to 120 mm Hg. Low-volume suction regulators may be used in gastrointestinal suctioning.\nConcepts: Arthropod venom (Hazardous or Poisonous Substance)\tRegulators, Suction, Low-Volume (Medical Device)\tOrthoses, Multipurpose Splint (Medical Device)\tInhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors (Genetic Function)\tmetabolism disorder diagnosis (Diagnosis)", + "output": "Regulators, Suction, Low-Volume (Medical Device)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a ribonucleotide variation in the sequence of a fully processed microRNA.\nConcepts: penta-snRNP complex (Cell Component)\tTaxonomy (biology)\tdemethyldiazepam (Benzodiazepines)\tRSS as Topic (Intellectual Product)\tMature miRNA Variant (Gene Product Sequence Variation)", + "output": "Mature miRNA Variant (Gene Product Sequence Variation)" + }, + { + "input": "Definition: something described as 6-membered aromatic ring structure with one nitrogen heteroatom.\nConcepts: Corticotropin-releasing factor (Therapeutic Hormone)\tPyridines (Organic Chemical)\ta group of nerve cell (Neuroanatomy)\tregulation of vegetative phase change (regulation of post-embryonic development)\tregulation of immune cell mediated cell death (regulation of leukocyte mediated immunity)", + "output": "Pyridines (Organic Chemical)" + }, + { + "input": "Definition: Health Care Related Organization described as an entity, facility, or distinct part of a facility providing analysis of family history, genetic laboratory testing and analysis, diagnosis of genetic trait, prognosis and options. Laboratory studies may be outsourced.\nConcepts: Ambulatory Health Care Facilities; Clinic/Center, Genetics (Health Care Related Organization)\tLymphocytopenia (White blood cell count laboratory result)\tnegative regulation of HGF receptor signalling pathway (negative regulation of signal transduction)\tSPLEEN NEOPL (Neoplasm of intra-abdominal organs)\timaginal disc-derived genitalia morphogenesis (post-embryonic genitalia morphogenesis)", + "output": "Ambulatory Health Care Facilities; Clinic/Center, Genetics (Health Care Related Organization)" + }, + { + "input": "Definition: Cyanobacteria described as a genus of CYANOBACTERIA in the family Synechococcaceae that is free-floating and occurs in various water environments attaching to algae and submersed plants.\nConcepts: Compression procedure (Therapeutic procedure)\tPannus Hickel 1991 (Cyanobacteria)\t5'-3' RNA polymerase activity (RNA polymerase activity)\tAnakinra (Recombinant interleukin 1 receptor blocking agent)\tSyndrome, MacLeod (Disease or Syndrome)", + "output": "Pannus Hickel 1991 (Cyanobacteria)" + }, + { + "input": "Definition: regulation of oogenesis described as any process that modulates the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.\nConcepts: Grade 4 CPK Increased, CTCAE (Finding)\tMyrica cerifera, homeopathic preparation (Homeopathic remedies letter M)\tprostate tumor antigen-activated autologous dendritic cell vaccine (Immunologic Factor)\tSymbolisms (History)\tregulation of oocyte development (regulation of oogenesis)", + "output": "regulation of oocyte development (regulation of oogenesis)" + }, + { + "input": "Definition: Group Attribute described as the development and maintenance of optimal physical, mental, spiritual, and social well-being and function with advancing age.\nConcepts: Well Aging (Wellness and Lifestyle)\tExpanded Prostate Cancer Index Composite for Clinical Practice Questionnaire (Clinical or Research Assessment Questionnaire)\tThyroid cartilage (EPIGLOTTIS AND LARYNX)\tLEC01-Sudden Accidental Death: Learned (Intellectual Product)\tInfrared rays (light spectrum)", + "output": "Well Aging (Wellness and Lifestyle)" + }, + { + "input": "Definition: protein-containing complex binding described as interacting selectively and non-covalently with a NuA4 histone acetyltransferase complex.\nConcepts: Peptococcaceae Rogosa 1971 (Clostridiales)\tOrdered component type reference set (Intellectual Product)\tNuA4 histone acetyltransferase complex binding (protein-containing complex binding)\tSociety, American Cancer (Professional Society)\tHow Often Felt Difficulties Too High To Overcome (Findings-Based Question)", + "output": "NuA4 histone acetyltransferase complex binding (protein-containing complex binding)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Veillonella atypica.\nConcepts: cAMP Responsive Element Binding Protein-Like 2 wt Allele (CREBL2 gene)\tHLCDGP1 (CSNK1A1 gene)\tVeillonella atypica (Rogosa 1965) Mays et al. 1982 (Bacterium)\tCD34/TK75 Retroviral Vector-Transduced Donor Lymphocytes (Allogeneic Lymphocyte)\tFAC09912 (Peds-FACIT-F Questionnaire Question)", + "output": "Veillonella atypica (Rogosa 1965) Mays et al. 1982 (Bacterium)" + }, + { + "input": "Definition: Environmental Effect of Humans described as the material that descends to the earth or water well beyond the site of a surface or subsurface nuclear explosion.\nConcepts: Antisense Oligonucleotide Therapy (Therapeutic or Preventive Procedure)\tWhole Body Counting (Scintillation Counting)\tInjectable Extended Release Suspension Dosage Form (Extended Release Suspension)\tRadioactive Fallout (Environmental Effect of Humans)\tnegative regulation of progression through cell cycle (Mitotic Cell Cycle)", + "output": "Radioactive Fallout (Environmental Effect of Humans)" + }, + { + "input": "Definition: something described as test codes of functional test questions associated with the mini-mental state examination (MMSE) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: PI3K/ALK/MTOR Pathway Mutation (Cell or Molecular Dysfunction)\thistidine decarboxylase (Enzymes)\tBypass of Impending Intestinal Obstruction (Bowel resection)\tMMS1TC (Intellectual Product)\tMeasurement of alpha-2 antiplasmin (Blood coagulation tests)", + "output": "MMS1TC (Intellectual Product)" + }, + { + "input": "Definition: developmental process involved in reproduction described as the increase in size or mass of the prostate gland where the increase in size or mass has the specific outcome of the progression of the gland, from its formation to its mature state.\nConcepts: Nephropathy due to Amphotericin (Drug-induced Nephropathy)\tprostate gland growth (developmental process involved in reproduction)\thimalaya proselect, abana 60 (Clinical Drug)\tComplete Pharyngeal Contraction (Impairment of Pharyngeal Contraction)\tNumber of Children in Household (Quantitative Concept)", + "output": "prostate gland growth (developmental process involved in reproduction)" + }, + { + "input": "Definition: Other general symptoms and signs described as an abnormal enlargement of the terminal phalanges accompanied by increased length-wise curvature of the nails, giving the digits a club-like appearance. Clubbing has been noted with a wide variety of conditions, including pulmonary and cardiac diseases, liver disorders, and disorders of the gastrointestinal tract.\nConcepts: heat/cold application (Therapeutic or Preventive Procedure)\tCisplatin-Vinblastine-Dacarbazine-Aldesleukin-Interferon alfa-2b (Regimen Used to Treat Melanoma)\tNaevus;intradermal (Benign melanocytic nevus)\tBRADYKININ (Amino Acid, Peptide, or Protein)\tFinger clubbing (Acquired deformity of upper limb)", + "output": "Finger clubbing (Acquired deformity of upper limb)" + }, + { + "input": "Definition: Pathology report described as a pathology report based upon samples obtained by or during surgery.\nConcepts: Stage III Oropharyngeal (p16-Negative) Throat Cancer (Neoplastic Process)\tSurgical Pathology Report (Pathology report)\tHalogenated hydrocarbon-containing product (Hydrocarbons, Halogenated)\tWorst Possible Depression (Intellectual Product)\ttrisomy; syndrome, 13 (Anomaly of chromosome pair 13)", + "output": "Surgical Pathology Report (Pathology report)" + }, + { + "input": "Definition: something described as catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O.\nConcepts: Lomustine Regimen (Regimen Used to Treat Central Nervous System Neoplasm)\tSkin Integrity Component (Intervention regimes)\tVENTRICULAR SEPTAL CLOSURE (Septal Defect Repair)\tSet of aggregated lymphoid nodules of small intestine (Anatomical set)\tmyristoyl-CoA 11-(Z) desaturase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)", + "output": "myristoyl-CoA 11-(Z) desaturase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)" + }, + { + "input": "Definition: Shields, Mechanical described as shields designed for mechanical protection and support of the nose. These trusses typically consist of a hard plastic, thermoplastic, or metallic cup-like prefabricated or custom-made device that is attached to the face using dressings and/or straps. Nose mechanical shields are mainly used to protect the external nasal bones and cartilage from injuries after trauma, illness, and/or surgery (e.g., rhinoplasty). Dedicated masks intended mainly to shield the nose are also available.\nConcepts: IVD Test Reagent/Kits, Home Assay, Whole Blood (Medical Device)\tTBC (protein-containing complex)\tShields, Mechanical, Nasal (Shields, Mechanical)\tCAM Nutritional Therapy (Medical Nutrition Therapy)\tphosphocellobiase activity (Molecular Function)", + "output": "Shields, Mechanical, Nasal (Shields, Mechanical)" + }, + { + "input": "Definition: something described as catalysis of the reaction: formate + a quinone = CO2 + a quinol.\nConcepts: intercellular transport (cellular process)\t4,5,6,7-Tetrachloro-2',4',5',7'-Tetraiodofluorescein (R [Preparations])\tformate:quinone oxidoreductase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor)\tmultiple TAA-loaded DC vaccine (Pharmacologic Substance)\tSymptom Interference with Life Score 4 (Clinical or Research Assessment Answer)", + "output": "formate:quinone oxidoreductase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, with a quinone or similar compound as acceptor)" + }, + { + "input": "Definition: Finding described as life-threatening respiratory and/or hemodynamic compromise (e.g. tension pneumothorax); urgent major care change required.\nConcepts: tumor antigen vaccine (Immunologic Factor)\tqatar (Geographic Area)\t1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-((2-methylamino)carbonyl)hydrazine (Pharmacologic Substance)\tGrade 4 Neonatal Pneumothorax (Finding)\tNPI1-Beliefs Untrue (NPI Questionnaire Question)", + "output": "Grade 4 Neonatal Pneumothorax (Finding)" + }, + { + "input": "Definition: Autonomic nervous system disorders described as diseases of the parasympathetic or sympathetic divisions of the AUTONOMIC NERVOUS SYSTEM; which has components located in the CENTRAL NERVOUS SYSTEM and PERIPHERAL NERVOUS SYSTEM. Autonomic dysfunction may be associated with HYPOTHALAMIC DISEASES; BRAIN STEM disorders; SPINAL CORD DISEASES; and PERIPHERAL NERVOUS SYSTEM DISEASES. Manifestations include impairments of vegetative functions including the maintenance of BLOOD PRESSURE; HEART RATE; pupil function; SWEATING; REPRODUCTIVE AND URINARY PHYSIOLOGY; and DIGESTION.\nConcepts: Copine I Gene (Gene or Genome)\tcentral tolerance induction (Biologic Function)\tNursery School Students (Age Group)\tPhosphatase and Tensin Homolog (Protein or Enzyme Type Measurement)\tANS Diseases (Neurological Disorders)", + "output": "ANS Diseases (Neurological Disorders)" + }, + { + "input": "Definition: something described as a preparation of human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene coupled to the signaling domains from CD28, 4-1BB (CD137) and CD3 zeta, and modified to express the cytokine interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the EGFR-overexpressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance.\nConcepts: AssessedResultRelationship.typeCode (Intellectual Product)\tacceptance of pollen (recognition of pollen)\tAnti-EGFR CAR-transduced IL-12-expressing T-lymphocytes (Antineoplastic Immune Cell)\tReception of language, unspecified (Mental functions of language)\tstage IIIB testicular cancer AJCC v7 (Stage III Testicular Cancer AJCC v6 and v7)", + "output": "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Commands task for put the pencil on top of the card and then put it back.\nConcepts: Camellia sinensis (Theaceae)\tADCCMD03 (Intellectual Product)\tVestibular function of determination of movement (Vestibular functions)\tPlaces, Work (Spatial Concept)\tAutologous NY-ESO-1 TCR-targeted T Lymphocytes (Cell)", + "output": "ADCCMD03 (Intellectual Product)" + }, + { + "input": "Definition: Carboxypeptidase described as cl- dependent, zinc glycoprotein that is generally membrane bound.\nConcepts: Not at all tired (Finding)\tAngiotensin Converting Enzyme (Amino Acid, Peptide, or Protein)\teyelid; absent (Congenital Abnormality)\tFilters, Air, Gas/Vapor (Air Filters)\tForensic Digital Data Copiers (Manufactured Object)", + "output": "Angiotensin Converting Enzyme (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Peri-; endo-; and myocarditis; cardiomyopathy described as condition in which there is a deviation from or interruption of the normal structure or function of the myocardium, the middle and thickest layer of the heart wall, composed of heart muscle.\nConcepts: Have Gained Weight (Findings-Based Question)\tresponse to zinc ion (Cell Function)\tWidespread Chronic Pain (Musculoskeletal and connective tissue pain and discomfort)\tCT-guided optical sensor-guided radiofrequency ablation (Therapeutic or Preventive Procedure)\tmyocardial disease (HEART: MYOCARDIUM/PERICARDIUM)", + "output": "myocardial disease (HEART: MYOCARDIUM/PERICARDIUM)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation.\nConcepts: gemella morbillorum (Streptococcus)\tRhizopus hangchow (Fungus)\tpositive regulation of T-helper 17 cell extravasation (positive regulation of CD8-positive, alpha-beta T cell extravasation)\tMeballymal (Barbiturate sedative)\tmmol/L/(kg/m2) (Quantitative Concept)", + "output": "positive regulation of T-helper 17 cell extravasation (positive regulation of CD8-positive, alpha-beta T cell extravasation)" + }, + { + "input": "Definition: something described as dye slowly enters but fails to exit the microvasculature.\nConcepts: Shoulder girdle structure (Pectoral girdle structure)\tAbsorption, Peritoneal (Organ or Tissue Function)\tWord Recognition: Word [14] (ADAS-Cog CDISC Version Questionnaire Question)\tTIMI 1 (Finding)\tauditory discrimination (Perceptual Discrimination)", + "output": "TIMI 1 (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in protein trafficking through the endoplasmic reticulum and Golgi apparatus.\nConcepts: ARF1 Gene (Gene or Genome)\tMicrobial Limit (quality assurance)\tsexual behavior (Detail of sexuality and sexual activity)\tCisterna of the Endosome (Cell Component)\tHapnes Boman Skeie syndrome (Congenital malposition of digit)", + "output": "ARF1 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as this gene is involved in cell cycle regulation.\nConcepts: mesoderm cell differentiation (Cell Function)\tContracture with ectodermal dysplasia and orofacial cleft syndrome (Congenital abnormality of oral cavity)\tCDK2/CYCLIN A-ASSOCIATED PROTEIN p45 (Gene or Genome)\tGastric Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v8 (Finding)\tcranial nerve V (Trigeminal nerve and its branches)", + "output": "CDK2/CYCLIN A-ASSOCIATED PROTEIN p45 (Gene or Genome)" + }, + { + "input": "Definition: High Grade Burkitt-Like Lymphoma described as stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3).\nConcepts: VZFOB (Quantitative Concept)\tStage II High Grade Burkitt-Like Lymphoma (High Grade Burkitt-Like Lymphoma)\tBACTERIAL ENDOCARDITIS (Infective endocarditis)\tN-(4-(((2,6-dimethylphenoxy)acetyl)amino)-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)tetrahydro-alpha-(1-methylethyl)-2-oxo-1(2H)-pydrimidineacetamide (Retroviral protease inhibitor)\tprotein transport along microtubule to mitotic spindle pole body (Cell Function)", + "output": "Stage II High Grade Burkitt-Like Lymphoma (High Grade Burkitt-Like Lymphoma)" + }, + { + "input": "Definition: Quantitative Concept described as a measurement of the length of the span between the protuberances of the parietal bones of the skull.\nConcepts: BIPADIST (Distance)\tSmall Intestinal Mucositis (Gastrointestinal mucositis)\tGlycosidase -RETIRED- (hydrolase activity)\tGrade 3 Recurrent laryngeal nerve palsy (Finding)\tPDK1 wt Allele (PDK1 gene)", + "output": "BIPADIST (Distance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein found in skin and eye cells that make melanin (a pigment that gives color to the skin and helps protect it from damage by ultraviolet light). People with certain changes in the gene for MC1R have a higher risk of developing melanoma (skin cancer that begins in melanocytes).\nConcepts: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor (Cell Function)\textrinsic motivation (Mental Process)\tketanserina (Serotonin Antagonists)\tMelanocyte-Stimulating Hormone Receptor (G-Protein-Coupled Receptors)\tEORTC QLQ-C30 Version 3 (Intellectual Product)", + "output": "Melanocyte-Stimulating Hormone Receptor (G-Protein-Coupled Receptors)" + }, + { + "input": "Definition: Congenital anomaly of endocrine gonad described as a disorder of sex development associated with anomalies in gonadal development that results in genital ambiguity of variable degree ranging from almost female phenotype to almost male phenotype in a patient carrying a male 46,XY karyotype. The disorder is heterogeneous and associated with partial abnormality of both Leydig cell and Sertoli cell function that may result from deletions or point mutations in the SRY gene or dose sensitive sex (NR0B1) locus duplication on the X chromosome. More important are mutations in steroidogenic factor 1 (SF1, NR5A1, Ad4BP). SF-1 is a nuclear receptor and regulator of multiple genes involved in adrenal and gonadal development, steroidogenesis, and the reproductive axis. Therefore, affected patients may also have adrenal insufficiency. Syndromic forms have been associated with WT-1 mutations, which lead to variable testicular dysgenesis and an increased risk of renal abnormalities, namely Wilms tumours or nephrotic syndrome.\nConcepts: Eribulin Hydrochloride Regimen (Regimen Used to Treat Endometrial Carcinoma)\t46,XY partial gonadal dysgenesis (Congenital anomaly of endocrine gonad)\tEarly awakening (Intellectual Product)\tThyrotropin Secretagogue (Pharmacologic Substance)\t13: 107665883-107657795 (Chromosome 13 Physical Location)", + "output": "46,XY partial gonadal dysgenesis (Congenital anomaly of endocrine gonad)" + }, + { + "input": "Definition: cellular diagnosis, childhood liver cancer described as a hepatocellular carcinoma occurring in children. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7955\" active clinical trials using this agent.\nConcepts: Basaloid Squamous Carcinoma of Esophagus (Squamous cell carcinoma of esophagus)\tExtra rib (Congenital Abnormality)\tregulation of blood pressure by chemoreceptor signalling pathway (blood pressure regulation)\tEnteral stomach tube levine (Enteral Feeding Supplies)\tChildhood Hepatocellular Carcinoma (cellular diagnosis, childhood liver cancer)", + "output": "Childhood Hepatocellular Carcinoma (cellular diagnosis, childhood liver cancer)" + }, + { + "input": "Definition: Intellectual Product described as a web site (http://cancernet.nci.nih.gov/) which hosts NCI's searchable clinical trials database containing information on over 1,800 active clinical trials.\nConcepts: repairing (SURGICAL REPAIRS, CLOSURES AND RECONSTRUCTIONS)\textrathymic T cell differentiation (T cell differentiation)\tresponse to host immune response (response to host defenses)\tCancerNet (Intellectual Product)\tWD4-Problem Doing Things for Relaxation (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)", + "output": "CancerNet (Intellectual Product)" + }, + { + "input": "Definition: Disorder of extraembryonic membrane described as a condition of abnormally low AMNIOTIC FLUID volume. Principal causes include malformations of fetal URINARY TRACT; FETAL GROWTH RETARDATION; GESTATIONAL HYPERTENSION; nicotine poisoning; and PROLONGED PREGNANCY.\nConcepts: endonuclease (Esterases)\tCorgi - Pembroke Welsh (Mammal)\tDeficient liquor (Disorder of amniotic cavity AND/OR membrane)\tmisfolded protein binding (Protein Binding)\tup regulation of phospholipid scramblase activity (regulation of phospholipid scramblase activity)", + "output": "Deficient liquor (Disorder of amniotic cavity AND/OR membrane)" + }, + { + "input": "Definition: Neoplastic Process described as an undifferentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular, squamous, or neuroendocrine differentiation.\nConcepts: lung cancer, undifferentiated large cell (cellular diagnosis, non-small cell lung cancer)\tperque hematin new frmulatio (Nutraceuticals)\tMelanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7 (Finding)\trespiratory syncytial virus RS (Pneumovirus)\tMedial Lenticulostriate Artery (Body Part, Organ, or Organ Component)", + "output": "lung cancer, undifferentiated large cell (cellular diagnosis, non-small cell lung cancer)" + }, + { + "input": "Definition: Emergency procedure described as a cesarean delivery that is not scheduled, planned or anticipated and is typically undertaken with short notice.\nConcepts: ventral hippocampal commissure (Body Space or Junction)\tBilateral Proliferative Retinopathy (Proliferative retinopathy)\tPIROXANTRONE HYDROCHLORIDE (Anthrapyrazole Antineoplastic Antibiotic)\tcoliphage T4 (Tequatrovirus)\tEmergency Cesarean Section (Therapeutic or Preventive Procedure)", + "output": "Emergency Cesarean Section (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the oculocutaneous albinism II (OCA2) gene, located at chromosome 15q11.2-q12, which is involved in producing the pigment melanin, the substance that gives skin, hair, and eyes their color. Mutations at this locus have been identified in individuals with light-colored hair and fair skin.\nConcepts: FACT-C Version 4 - I Can Digest My Food Well (FACT-C Version 4 Questionnaire Question)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CAV3 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tStage 0 Non-Small Cell Lung Cancer (Stage 0 Lung Cancer AJCC v6 and v7)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, OCA2 (Medical Device)\tDefinedActivity.repeatQuantity (Quantitative Concept)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, OCA2 (Medical Device)" + }, + { + "input": "Definition: something described as the initial segment of a nerve leaving the cervical spine. There are eight pairs of cervical roots, each consisting of two parts: the ventral (efferent motor) and the dorsal (afferent sensory) root which unite to form a single spinal nerve. All cervical nerves exit superiorly to their corresponding vertebrae with the exception of C8, which exits inferiorly to the C7 vertebra.\nConcepts: Anti-BCMA Antibody-drug Conjugate AMG 224 (Pharmacologic Substance)\tColonoscopy with Marking of Cancerous Polyp (colonoscopy)\tRumination, Cognitive (Cognition)\t/10^4 (Quantitative Concept)\tcervical spinal nerve root structure (Structure of soft tissue of cervical region of back)", + "output": "cervical spinal nerve root structure (Structure of soft tissue of cervical region of back)" + }, + { + "input": "Definition: something described as the population from which study subjects are recruited.\nConcepts: arsenic level test (biochemical test)\tBCG Tokyo-172 strain vaccine (Pharmacologic Substance)\tSample Study Population (Study Population)\tTAPE (Biomedical or Dental Material)\tsyncytium formation by plasma membrane fusion (Cell fusion)", + "output": "Sample Study Population (Study Population)" + }, + { + "input": "Definition: something described as terminology used in Individual Case Safety Reports to specify a type of substance administration.\nConcepts: long-term memory (Finding of memory performance)\tENSAT Staging Finding v7 (Other Finding)\tSubstance Administration Individual Case Safety Report Terminology (Intellectual Product)\tsecondary olfactory areas (Body Location or Region)\tAtrium, Left (Left side of heart)", + "output": "Substance Administration Individual Case Safety Report Terminology (Intellectual Product)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 8p\nConcepts: down regulation of mitotic telomere tethering at nuclear periphery (regulation of mitotic telomere tethering at nuclear periphery)\tA2B5 (Gangliosides)\tAuditory Threshold (Quantitative Concept)\tFP Regimen (Therapeutic or Preventive Procedure)\t8p21-p11.2 (Cell Component)", + "output": "8p21-p11.2 (Cell Component)" + }, + { + "input": "Definition: Tooth structure described as the most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces.\nConcepts: molar (Tooth structure)\tNeedles, Ophthalmic Procedure (Medical Device)\tlive-attenuated Listeria monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine ADU-623 (Attenuated Bacteria Vaccine)\tSystem for Primary Care Professionals (Computer Systems)\tassembly of spliceosomal tri-snRNP (spliceosomal snRNP assembly)", + "output": "molar (Tooth structure)" + }, + { + "input": "Definition: Findings-Based Question described as a question about how much an individual worries or worried about their cancer coming back.\nConcepts: Short form McGil pain question (Intellectual Product)\tE7107 (Antibiotics, Antineoplastic)\tMultiple antimicrobial drug resistant bacteria (Bacterium)\tcellular triglyceride homeostasis (triglyceride homeostasis)\tI Worry About My Cancer Coming Back (Findings-Based Question)", + "output": "I Worry About My Cancer Coming Back (Findings-Based Question)" + }, + { + "input": "Definition: something described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.\nConcepts: status pregnancy (Finding)\tventral anterior cingulate area 24 (Brodmann area)\tSTPK13 protein, human (Amino Acid, Peptide, or Protein)\tAZOCARMINE B (Organic Chemical)\tProstate transurethral resection (Transurethral relief of prostatic and bladder neck obstruction)", + "output": "AZOCARMINE B (Organic Chemical)" + }, + { + "input": "Definition: Abnormality of the humerus described as absence (due to failure to form) or underdevelopment of the humerus.\nConcepts: Aplasia/hypoplasia of the humerus (Finding)\tGCG Gene Product (Amino Acid, Peptide, or Protein)\tUncinate fasciculus of pons (frontal lobe)\tMyelin Associated Glycoprotein (Biologically Active Substance)\tED1-Few Words or Random Answers/Shouting (Intellectual Product)", + "output": "Aplasia/hypoplasia of the humerus (Finding)" + }, + { + "input": "Definition: Medical Device described as a magnesium test system is a device intended to measure magnesium levels in serum and plasma. Magnesium measurements are used in the diagnosis and treatment of hypomagnesemia (abnormally low plasma levels of magnesium) and hypermagnesemia (abnormally high plasma levels of magnesium).\nConcepts: Planned Criterion Group Composition Relationship Sequence Number (Sequence Number)\tAcids, Mandelic (Hydroxy Acids)\tAppendiceal Carcinoma cM1 TNM Finding v7 (Appendiceal Carcinoma Clinical Distant Metastasis TNM Finding v7)\tPHOTOMETRIC METHOD, MAGNESIUM (Medical Device)\tTrichodysplasia with amelogenesis imperfecta syndrome (Amelogenesis Imperfecta)", + "output": "PHOTOMETRIC METHOD, MAGNESIUM (Medical Device)" + }, + { + "input": "Definition: mineral analysis described as a measurement of the lead in a biological specimen.\nConcepts: Pb (Chemical procedure)\tPQL1814 (Intellectual Product)\tAkesson syndrome (Disease or Syndrome)\tapc (Cardiac Arrhythmia)\tEstimated intake of vitamin B12 and vitamin B12 derivative in 24 hours (Quantitative Concept)", + "output": "Pb (Chemical procedure)" + }, + { + "input": "Definition: Medical Device described as devices designed to restore or assist the physiologic function of a patient's cardiac and/or respiratory system for a short time when the performance of one or both of those systems is inadequate to sustain life or is completely absent. Most resuscitators are simple in design and operation, permitting their use in emergencies both inside and outside the hospital, and also during transportation. Resuscitators are typically used in emergency rooms, ambulances, patient care areas throughout the hospital, and in emergency rescue.\nConcepts: protocatechualdehyde:oxygen oxidoreductase activity (Molecular Function)\tGlucosephosphatase Deficiency (Congenital anomaly of skeletal muscle)\tHFE Protein (Amino Acid, Peptide, or Protein)\tResuscitator, NOS (Medical Device)\tupregulation of catecholamine uptake during transmission of nerve impulse (positive regulation of amine transport)", + "output": "Resuscitator, NOS (Medical Device)" + }, + { + "input": "Definition: something described as the level of governmental organization and function at the national or country-wide level.\nConcepts: Interrupter Device (Device Component or Accessory)\tFederal Government (political unit)\tPrimary Adrenal Insufficiency (Disease or Syndrome)\tMediastinal Germ Cell Tumor with Somatic-Type Malignancy (Malignant germ cell neoplasm of mediastinum)\trhabdomere development (Cell Function)", + "output": "Federal Government (political unit)" + }, + { + "input": "Definition: Cell Component described as a protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle.\nConcepts: SeqA-DNA complex location (Cell Component)\tPURULENT DISCHARGE (BODY AS A WHOLE - GENERAL DISORDERS)\tendocardial cushion cell fate commitment (Cell Function)\tCT5.2 Positive (Positive Laboratory Test Result)\tTAPVR Type I (Disease or Syndrome)", + "output": "SeqA-DNA complex location (Cell Component)" + }, + { + "input": "Definition: Anatomical Abnormality described as partial duplication of a phalanx of second toe.\nConcepts: Ptelea trifoliata / hop tree / wafer ash (Plant)\tPartial duplication of phalanx of the 2nd toe (Duplication of the phalanges of the 2nd toe)\tMetastatic non-small cell carcinoma (Malignant epithelial neoplasm - category)\tupregulation of transcription of nuclear rRNA large Pol I transcript (positive regulation of transcription by RNA polymerase I)\tup-regulation of sprouting of injured axon (positive regulation of developmental growth)", + "output": "Partial duplication of phalanx of the 2nd toe (Duplication of the phalanges of the 2nd toe)" + }, + { + "input": "Definition: Pathologic Function described as accumulation of blood in the SUBDURAL SPACE with delayed onset of neurological symptoms. Symptoms may include loss of consciousness, severe HEADACHE, and deteriorating mental status.\nConcepts: Subdural Hematoma, Chronic (Pathologic Function)\tADT01-Injured Because of Your Drinking (Intellectual Product)\tNeuroblastoma RAS Viral (v-ras) Oncogene Homolog c.183A>C (Cell or Molecular Dysfunction)\tClinical Complete Remission (Disease Response)\tsyndrome; afferent loop, postgastric surgery (Duodenal Diseases)", + "output": "Subdural Hematoma, Chronic (Pathologic Function)" + }, + { + "input": "Definition: Neoplasms described as the presence of an adenoma in the cortex of the kidney.\nConcepts: renal neoplasm cortical adenoma (Benign tumor of renal parenchyma)\tprotein localization in plasma membrane (Cell Function)\tPaced Tapping - Total Trials Completed (Paced Tapping Functional Test Question)\tInstinctive Behavior (Behavior)\tantepartum (Temporal Concept)", + "output": "renal neoplasm cortical adenoma (Benign tumor of renal parenchyma)" + }, + { + "input": "Definition: Immunologic Factor described as an antinuclear antibody directed against small nuclear ribonucleoproteins (snRNPs), that is highly specific, but has poor sensitivity for systemic lupus erythematosus (SLE). Presence of anti-Sm antibodies are associated with central nervous system, kidney, lung and cardiac involvement in SLE, but are not indicative of disease activity.\nConcepts: EC 1.14.16.4 (Oxidoreductase)\tPhytotherapy (Therapeutic procedures NEC)\tBiomechanics Platforms (Medical Device)\tBlood group antibody Smith (Extractable nuclear antibody)\tFLJ36832 (Gene or Genome)", + "output": "Blood group antibody Smith (Extractable nuclear antibody)" + }, + { + "input": "Definition: something described as a role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure always involves partial excision of the specified anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where partial excision is explicit or can be inferred (e.g. biopsy). The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.\nConcepts: Procedure Has Partially Excised Anatomy (Conceptual Entity)\tPaced Tapping - Median Interval Self All (Paced Tapping Functional Test Question)\ta wheelchair anti-tipping device (Medical Device)\tCystectomy, partial; simple (Operation on bladder)\tbeta-galactosidase activity (Molecular Function)", + "output": "Procedure Has Partially Excised Anatomy (Conceptual Entity)" + }, + { + "input": "Definition: something described as a flattened vertebral body shape with reduced distance beween the vertebral endplates affecting the thoracic spine.\nConcepts: de pointe torsades (Ventricular arrhythmia)\tNPI1J04 (Intellectual Product)\tThoracic platyspondyly (Platyspondyly)\tEyelid Carcinoma cN1a TNM Finding v8 (Eyelid Carcinoma cN1 TNM Finding v8)\tBPI209C (BPI Short Form Questionnaire Question)", + "output": "Thoracic platyspondyly (Platyspondyly)" + }, + { + "input": "Definition: Developmental entity described as a process that promotes the formation of new, more mature, or differentiated tissues, organs, or organ systems. May be, and often is, part of general development, but is not restricted to occur only during general development.\nConcepts: Grade 4 Biliary Fistula, CTCAE (Finding)\tDevelopmental process (Biological Processes)\tcollateral sprouting of injured axon (Organ or Tissue Function)\tGabriele-de Vries Syndrome (Disease or Syndrome)\tPiscirickettsia Fryer et al. 1992 (Piscirickettsiaceae)", + "output": "Developmental process (Biological Processes)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of alpha glutathione-s-transferase compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: BCR/ABL Fusion Protein with M351T (Fusion Proteins, bcr-abl)\tC-SSRS Children's Since Last Visit - Most Lethal Suicide Attempt Potential Lethality (Intellectual Product)\tGCLM gene (Protein Complex Subunit Gene)\tHepatitis B Virus Surface Antibody (Immunologic Factor)\tAlpha Glutathione-S-Transferase to Creatinine Ratio Measurement (Laboratory Procedure)", + "output": "Alpha Glutathione-S-Transferase to Creatinine Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a release characteristic where a dose form displays a rate and time of release of the active substance(s) in the dose form based on their intrinsic properties and also displays a delayed release of some of the active substance(s) within the same dose form. This may be achieved by a special formulation design, manufacturing process or other methods.\nConcepts: 3H-dT-LI (Clinical Attribute)\tFanconi Anemia, Complementation Group S Protein Variant (Gene Product Sequence Variation)\tETRP0101 (E-TRIP Clinical Classification Question)\tFUNGUS DIS (SKIN, NAILS, HAIR)\tConventional release and prolonged-release (Conventional release)", + "output": "Conventional release and prolonged-release (Conventional release)" + }, + { + "input": "Definition: regulation of cellular component biogenesis described as any process that modulates the frequency, rate or extent of extracellular matrix assembly.\nConcepts: regulation of extracellular matrix assembly (regulation of cellular component biogenesis)\tDDS03-How Best to Help: Moderate (Intellectual Product)\tOccupancy Alarm Systems (Medical Device)\tCELLULARITY, INCREASED (Physical shape)\tExtracellular Signal-regulated Kinase 1/2 Inhibitor ASTX029 (Organic Chemical)", + "output": "regulation of extracellular matrix assembly (regulation of cellular component biogenesis)" + }, + { + "input": "Definition: glomerulus vasculature morphogenesis described as the process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.\nConcepts: regulation of exonuclease activity (regulation of nuclease activity)\tInner Enamel Epithelium (Epithelium)\tmetanephric glomerulus vasculature morphogenesis (Organ or Tissue Function)\tmeiotic attachment of telomeric heterochromatin to spindle pole body (microtubule-based process)\tDNA Damage Repair (cellular response to DNA damage stimulus)", + "output": "metanephric glomerulus vasculature morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: Oligodeoxyribonucleotides described as short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.\nConcepts: Short chordae tendineae of the mitral valve (Abnormal morphology of the chordae tendinae of the mitral valve)\tTea Dosage Form Category (Biomedical or Dental Material)\tDNA Primers (Nucleic Acid, Nucleoside, or Nucleotide)\tMerkel Cell Carcinoma Pathologic Distant Metastasis TNM Finding v7 (Finding)\tprofessional role (Social Role)", + "output": "DNA Primers (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Site-specific disorder of skin described as skin lesion, greater than 2 cm, flat, colored; differs from a macule only in size.\nConcepts: ajmaline metabolic process (organic hydroxy compound metabolic process)\tG-protein coupled purinergic nucleotide receptor signaling pathway (Molecular Function)\tVaginal Infection (Finding)\tPlaque Lesion (Dermal and epidermal conditions NEC)\tpositive regulation of nurse cell apoptotic process (regulation of nurse cell apoptotic process)", + "output": "Plaque Lesion (Dermal and epidermal conditions NEC)" + }, + { + "input": "Definition: something described as a paralytic poliomyelitis syndrome associated with the orally administered live attenuated strain of the poliovirus, OPV.\nConcepts: Bucket handle rib motion (Finding of movement of ribs)\tpoliomyelitis paralytic vaccine-associated (Vaccination related complications)\tCDISC Questionnaire KFSS Test Code Terminology (Intellectual Product)\tFree prostate-specific antigen (Laboratory Procedure)\tPrimary CD59 deficiency (Hereditary disorder of immune system)", + "output": "poliomyelitis paralytic vaccine-associated (Vaccination related complications)" + }, + { + "input": "Definition: Abnormality of urine bicarbonate concentration described as abnormally decreased concentration of hydrogencarbonate in the urine. []\nConcepts: Decreased urine HCO3 concentration (Finding)\tmyeloperoxidase (Substance with white blood cell enzyme mechanism of action)\tCardiac Valvular Stenosis Severity (Qualitative Concept)\tL1Ag (Immunologic Factor)\tShort QT Syndrome Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Cardiac Disorder, Arrhythmia, Short QT Syndrome)", + "output": "Decreased urine HCO3 concentration (Finding)" + }, + { + "input": "Definition: something described as human KDM7A wild-type allele is located in the vicinity of 7q34 and is approximately 92 kb in length. This allele, which encodes lysine-specific demethylase 7A protein, plays a role in brain development and histone modification.\nConcepts: recombinant fowlpox-prostate specific antigen vaccine (fowlpox virus vaccine)\tdata clarification (Functional Concept)\tGABAergic Modulators (Pharmacologic Substance)\tPost-transplant lymphoproliferative disorder (Monoclonal), NOS (Neoplastic Process)\tKDM7A wt Allele (Gene or Genome)", + "output": "KDM7A wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as an intravenous formulation containing docetaxel, a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata, with potential antineoplastic activity. Taxol analogue SID 530 binds to and stabilizes tubulin, inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death.\nConcepts: IVD Panels, Human Genetics, Eye Disorder, Retinopathy, Retinitis Pigmentosa/Leber Congenital Amaurosis, Mutation (Medical Device)\tTaxol Analogue SID 530 (Taxane-Pocket Binding Agent)\tregulation of dephosphorylation (Molecular Function)\tGLYPHOSINE (Organic Chemical)\tgiant axonal neuropathy (Gene or Genome)", + "output": "Taxol Analogue SID 530 (Taxane-Pocket Binding Agent)" + }, + { + "input": "Definition: something described as cutaneous melanoma involving two to three regional lymph nodes, or involving the regional intra-lymphatic system without nodal involvement.\nConcepts: Swollen lymph nodes affecting all regions of the body (Disorder of lymph node)\tFucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific) wt Allele (FUT4 gene)\tReduced taurine levels in the blood (Finding)\tWatery eye (Finding of lacrimation)\tpN2 Melanoma of the Skin v6 (Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v6)", + "output": "pN2 Melanoma of the Skin v6 (Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v6)" + }, + { + "input": "Definition: Cell Count described as the determination of the amount of circulating endothelial cells present in a sample.\nConcepts: Abnormal central microtubular pair morphology of respiratory motile cilia (Anatomical Abnormality)\tPetroselinums (Apiaceae)\tStenosis of aortic valve (Abnormality of aortic valve)\tValvotomy (Valvular Surgery)\tCirculating Endothelial Cells (Laboratory Procedure)", + "output": "Circulating Endothelial Cells (Laboratory Procedure)" + }, + { + "input": "Definition: Stent, device described as a hollow tube that is advanced into an obstructed bile duct to allow the flow of bile into the bowel.\nConcepts: Biliary Duct Stent (Stent, device)\tBlack Elderberries (Plant)\tGrade 2 Ovarian Rupture, CTCAE (Ovarian Rupture, CTCAE)\tAbnormality of shape of incisor (Anatomical Abnormality)\tcap mRNA methylation (mRNA methylation)", + "output": "Biliary Duct Stent (Stent, device)" + }, + { + "input": "Definition: Peripheral axonal neuropathy described as progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.\nConcepts: Ability to do Heavy Household Chores (Intellectual Product)\tNon-Neoplastic Chest Wall Disorder (Disease or Syndrome)\tPENIS PROSTHESIS (Medical Device)\t1-18:1-2-18:2-phosphatidylcholine desaturase activity (Molecular Function)\tMotor axonal neuropathy (Disease or Syndrome)", + "output": "Motor axonal neuropathy (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a complication requiring surgical, endoscopic, or radiological intervention.\nConcepts: Grade III (Clavien-Dindo Classification)\tsecretory granule organization (vesicle organization)\tGrade 4 Bronchial Infection, CTCAE (Finding)\tONEM (Clinical or Research Assessment Questionnaire)\tBetween Severe and Very severe (Intellectual Product)", + "output": "Grade III (Clavien-Dindo Classification)" + }, + { + "input": "Definition: central nervous system neuron differentiation described as the process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.\nConcepts: cerebellar basket cell differentiation (central nervous system neuron differentiation)\tmating-type M-factor pheromone receptor activity (mating-type factor pheromone receptor activity)\tWD5D6 4 (Intellectual Product)\tCTSL wt Allele (Gene or Genome)\tvitritis (Inflammation of orbit)", + "output": "cerebellar basket cell differentiation (central nervous system neuron differentiation)" + }, + { + "input": "Definition: Paenibacillus described as a taxonomic grouping of facultative anaerobic, endospore-forming bacteria that can be assigned to the genus Paenibacillus.\nConcepts: Paenibacillus Ash et al. 1994 emend. Behrendt et al. 2010 (Bacterium)\tComplement C3a DesArg Measurement (Complement C3a measurement)\tNeuroepithelial Neoplasm (Neuronal and mixed neuronal-glial tumor)\tp16-INK4 Protein Variant Arg80Xxx (CDKN2A Protein Variant)\tnucleotide-excision repair, preincision complex formation (Genetic Function)", + "output": "Paenibacillus Ash et al. 1994 emend. Behrendt et al. 2010 (Bacterium)" + }, + { + "input": "Definition: indole alkaloid metabolic process described as the chemical reactions and pathways involving 3alpha(S)-strictosidine.\nConcepts: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor (oxidoreductase activity, acting on the CH-NH group of donors)\tIRF1 Gene (Transcription Coactivator Gene)\t3alpha(S)-strictosidine metabolic process (Molecular Function)\tEPIC-CP - Vitality/Hormonal Symptom Score (Intellectual Product)\tCannabinoid Receptor Agonists (Pharmacologic Substance)", + "output": "3alpha(S)-strictosidine metabolic process (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as a glenoid fossa prosthesis is a device that is intended to be implanted in the temporomandibular joint to augment a glenoid fossa or to provide an articulation surface for the head of a mandibular condyle.\nConcepts: Multifocal Lesion (Finding)\tTransient ischemic attacks (Nervous System Disorders, CTCAE)\tGLENOID FOSSA PROSTHESIS (Medical Device)\tFacility Regulation and Control (Social Control, Formal)\tProminent glabella microcephaly hypogenitalism (Disorder of face)", + "output": "GLENOID FOSSA PROSTHESIS (Medical Device)" + }, + { + "input": "Definition: Acute GVH disease described as acute graft versus host disease occurring in the gastrointestinal tract.\nConcepts: nonblood rheology (Measurement)\tNon-Hematologic Malignancy (Malignant Neoplasms)\tGastrointestinal Tract Acute Graft Versus Host Disease (Disease or Syndrome)\tinitial segment (cellular anatomical entity)\tUnconventional Myosin-Va (Cytoskeletal Proteins)", + "output": "Gastrointestinal Tract Acute Graft Versus Host Disease (Disease or Syndrome)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Young Children - Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Being tense.\nConcepts: Gyrus, Rectus (Gyrus of brain)\tSF-36 v2.0 Standard - Question 3e (SF36 v2 0 Standard Questionnaire Question)\tmodulation by symbiont of host response to abiotic stimulus (regulation of response to stimulus)\tTSCYC156 (TSCYC Questionnaire Question)\tAS03-Adjuvanted H1N1 Pandemic Influenza Vaccine (Vaccines, Inactivated)", + "output": "TSCYC156 (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as a process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum.\nConcepts: MIDDLE PHALANX 4 OF THE HAND (Structure of phalanx of middle finger)\tER organization and biogenesis (organelle organization)\ttherapeutic angiotensin-(1-7) (Biological Factors)\tGi Go G Proteins (Enzyme)\tTamponade cardiac (Viscus structure finding)", + "output": "ER organization and biogenesis (organelle organization)" + }, + { + "input": "Definition: Intellectual Product described as quick Inventory of Depressive Symptomatology - Clinician-Rated (QIDS-C) (Copyright UT Southwestern Medical Center at Dallas. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, Markowitz JC, Ninan PT, Kornstein S, Manber R, Thase ME, Kocsis JH, Keller MB. The 16-item Quick Inventory of Depressive Symptomatology (QIDS) Clinician Rating (QIDS-C) and Self-Report (QIDS-SR): A psychometric evaluation in patients with chronic major depression. Biological Psychiatry, 54:573-583, 2003).\nConcepts: Amylopectin (Polysaccharides)\talimentary canal (Digestive tract part)\tGUCA2 (GUCA2A gene)\tQIDSC1 (Intellectual Product)\tSea urchin (Pharmacologic Substance)", + "output": "QIDSC1 (Intellectual Product)" + }, + { + "input": "Definition: Glutamate Plasma Membrane Transport Proteins described as a glutamate plasma membrane transporter protein that is primarily expressed in the RETINA.\nConcepts: Subependymal gray matter heterotopia (Central Nervous System)\tExcitatory Amino Acid Transporter 5 (Biologically Active Substance)\tWW Domain Containing Transcription Regulator 1/Calmodulin Binding Transcription Activator 1 Fusion Gene (Fusion Gene)\ttanibirumab (Immunologic Factor)\tJRB (Language)", + "output": "Excitatory Amino Acid Transporter 5 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a measurement of the mumps virus IgG antibody in a biological specimen.\nConcepts: V8-Asp/Glu Protein Cleavage Reagent (Indicator, Reagent, or Diagnostic Aid)\tC-SSRS Already Enrolled Subjects Questionnaire Question (Intellectual Product)\tMumps Virus IgG Antibody (Immunologic Tests)\tShame (Emotional states)\tAngelman syndrome (Congenital neurologic anomalies)", + "output": "Mumps Virus IgG Antibody (Immunologic Tests)" + }, + { + "input": "Definition: Air Pollution described as an odorless, tasteless, poisonous gas, CO, that results from the incomplete combustion of carbon. Inhalation causes central nervous system damage and asphyxiation.\nConcepts: Aromasin/Ibrance (Therapeutic or Preventive Procedure)\tCarboneum oxygenisatum (Inorganic carbon)\tHemoglobin E/Total Hemoglobin (Hemoglobin measurement)\tremoval of adenoids (Tonsillar therapeutic procedures)\tVSORRESU (Quantitative Concept)", + "output": "Carboneum oxygenisatum (Inorganic carbon)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as propagation (or reproduction) of a species in its natural environment or in captive settings. Includes birth rate and breeding success. Compare ANIMAL DOMESTICATION, EUGENICS, and SELECTIVE BREEDING.\nConcepts: Stage III Malignant Ovarian Germ Cell Tumor (Neoplastic Process)\ttrachea cartilage morphogenesis (cartilage morphogenesis)\tSpeckled calcifications in the end part of the big toe bone (Abnormality of the epiphyses of the hallux)\tstrand invasion involved in gene conversion at mating-type locus (Reproductive process)\tAnimal Breeding (Thesaurus of Psychological Index Terms)", + "output": "Animal Breeding (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: EYES AND EYE APPENDAGES described as the core of the crystalline lens, surrounded by the cortex.\nConcepts: Beta-glucuronidase measurement, NOS (Protein or Enzyme Type Measurement)\tStructure of nucleus of lens (Lens, Crystalline)\tWD4-Getting Out of Your Home (Intellectual Product)\t7: 54860934-55049240 (Chromosome 7 Physical Location)\tTertiary Chorionic Villus (Embryonic Structure)", + "output": "Structure of nucleus of lens (Lens, Crystalline)" + }, + { + "input": "Definition: Disease or Syndrome described as duplication of the long arm of chromosome 6 with intrauterine growth retardation, dolichocephaly, depressed nasal bridge, almond-shaped palpebral fissures, short neck, flexion contractures of the wrists, hypertonia, and retarded mental development.\nConcepts: (1->4)-beta-D-galactan binding (Molecular Function)\tDistal Duplication 6q (6q+ Syndrome, Partial)\tPORPHYROMONAS (Bacteroidaceae)\tMEK Kinase 1 (Amino Acid, Peptide, or Protein)\tNuremberg Code (Document type)", + "output": "Distal Duplication 6q (6q+ Syndrome, Partial)" + }, + { + "input": "Definition: something described as stage IIIB includes: (T4, N0, M0); (Any T, N1, M0). T4: Tumor involving local extrahepatic structures by direct invasion. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis. (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C134618\" active clinical trials using this agent.\nConcepts: Grade 3 Cardiac troponin T increased (Finding)\tBullet-shaped middle phalanx of the 3rd toe (Anatomical Abnormality)\tMODIFY (Functional Concept)\tstage IIIB intrahepatic bile duct cancer AJCC v8 (Stage III Intrahepatic Bile Duct Cancer AJCC v8)\tdown-regulation of type I restriction endodeoxyribonuclease activity (negative regulation of restriction endodeoxyribonuclease activity)", + "output": "stage IIIB intrahepatic bile duct cancer AJCC v8 (Stage III Intrahepatic Bile Duct Cancer AJCC v8)" + }, + { + "input": "Definition: something described as an orally bioavailable imidazopyridazine and inhibitor of Janus kinase 2 mutant V617F (JAK2V617F), with potential antineoplastic activity. Upon oral administration, gandotinib selectively and competitively inhibits the activation of JAK2V617F, which may result in the inhibition of the JAK-STAT signaling pathway and the induction of apoptosis in JAK2V617F-expressing tumor cells. JAK2V617F has a substitution of phenylalanine for valine at amino acid position 617 and plays a key role in tumor cell proliferation and survival.\nConcepts: 3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo(1,2-b)pyridazin-6-amine (Pharmacologic Substance)\tPlasminogen Activator Inhibitor-1 Antigen Measurement (Laboratory Procedure)\tresearch coordinator (Study Personnel)\tpulsatilla (Organic Chemical)\tMonosomy 19q13.11 (Intellectual Disability)", + "output": "3-(4-chloro-2-fluorobenzyl)-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholinomethyl)imidazo(1,2-b)pyridazin-6-amine (Pharmacologic Substance)" + }, + { + "input": "Definition: Disorder of lipoprotein AND/OR lipid metabolism described as a type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.\nConcepts: public health nurs (Biomedical Occupation or Discipline)\tCandida krusei (Pichia)\tParalemmin 2 (Amino Acid, Peptide, or Protein)\tFamilial comb hyperlipidaemia (Lipid Metabolism, Inborn Errors)\tketone body anabolism (ketone body metabolic process)", + "output": "Familial comb hyperlipidaemia (Lipid Metabolism, Inborn Errors)" + }, + { + "input": "Definition: something described as the determination of the amount of P-selectin present in a sample.\nConcepts: PSELECT (Laboratory Procedure)\t2-hydroxyadenine deaminase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)\tFerredoxin--nitrate reductase (Nitrite Reductase)\tgranuloma eosinophilic (Pathologic Function)\tRELAPSED DISEASE (Clinical course)", + "output": "PSELECT (Laboratory Procedure)" + }, + { + "input": "Definition: Benign genital neoplasm described as a benign neoplasm arising from the parathyroid glands.\nConcepts: Benign neoplasm of parathyroid gland (Benign genital neoplasm)\tMDS-UPDRS - Eating Tasks (Intellectual Product)\tTrial Visits Domain (Intellectual Product)\tESRSA1-Akathisia: Subjective (ESRS-A Clinical Classification Question)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, HAMP (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Benign neoplasm of parathyroid gland (Benign genital neoplasm)" + }, + { + "input": "Definition: Glomerulonephritis described as inflammation of the glomeruli, in which all glomeruli are affected, resulting in renal failure.\nConcepts: Aborted Embryos (embryo and fetus)\tI-TUBUL (Functional Concept)\tPituitary Gland Double Adenomas (Neoplastic Process)\tHypoplastic distal humeri (Limb structure)\tGlomerulonephritis diffuse (Disease or Syndrome)", + "output": "Glomerulonephritis diffuse (Disease or Syndrome)" + }, + { + "input": "Definition: something described as this gene is involved in the regulation of apoptosis.\nConcepts: NDPP (Apoptosis Regulation Gene)\tGAN (Peripheral Nervous System Diseases)\tWnt 5a Protein (Biologically Active Substance)\tNEWLWIND (Functional Concept)\tFair (Qualitative Concept)", + "output": "NDPP (Apoptosis Regulation Gene)" + }, + { + "input": "Definition: Chromosome replaced with ring or dicentric described as a rare chromosomal anomaly syndrome with a highly variable phenotype. Principle characteristics are pre and postnatal growth retardation, short stature, developmental delay, mild to severe intellectual disability, microcephaly and mild dysmorphic features (including triangular face, dysplastic ears, upslanting palpebral fissures, epicanthic folds, broad nasal bridge, full nasal tip, long philtrum, downturned corners of the mouth, and micro/retrognathia). Additional manifestations reported include hypotonia, mild articular limitation, hearing loss, digital anomalies (clinodactyly, brachydactyly), cafe au lait patches and hypospadias.\nConcepts: Snores (Nasopharynx)\tCD70 Molecule (Amino Acid, Peptide, or Protein)\tPressure Issue (Infusion or Flow Problem)\tShop, Hospital (Hospital Administration)\tRing chromosome 3 (Chromosome replaced with ring or dicentric)", + "output": "Ring chromosome 3 (Chromosome replaced with ring or dicentric)" + }, + { + "input": "Definition: something described as a response indication the administration of adjuvant post-operative radiation therapy is unknown.\nConcepts: Adjuvant Post-operative Radiation Therapy Administration Unknown (Finding)\tBlinding Schema (Study)\tCompounds, Diazonium (Azo Compounds)\toral behavior (Behavior)\t(mL/min)/(ug/kg/d) (Quantitative Concept)", + "output": "Adjuvant Post-operative Radiation Therapy Administration Unknown (Finding)" + }, + { + "input": "Definition: Discipline of Nursing described as nursing care of the aged patient given in the home, the hospital, or special institutions such as nursing homes or psychiatric institutions.\nConcepts: Digilanides (Organic Chemical)\tnegative regulation of cytolysis in other organism (negative regulation of killing of cells of other organism)\tNURS GERIATRIC (Care given by nurses)\tMegakaryocyte-Erythroid Progenitor Cells (Myeloid Progenitor Cells)\tUveal Melanoma cM1b TNM Finding v8 (Finding)", + "output": "NURS GERIATRIC (Care given by nurses)" + }, + { + "input": "Definition: Wound Infection described as an infection that occurs at a surgical site within 30 days after an operation.\nConcepts: INCISIONAL INFECTION (Injury by mechanism)\tDevice Complication (Finding)\tFAC01831 (FACT-LYM Version 4 Questionnaire Question)\tRoutine (Qualitative Concept)\t6MWT - Distance at 3 Minutes (Intellectual Product)", + "output": "INCISIONAL INFECTION (Injury by mechanism)" + }, + { + "input": "Definition: Peripheral Nervous System Diseases described as general term indicating inflammation of a peripheral or cranial nerve.\nConcepts: Neuritides, Peripheral (Non-Neoplastic Peripheral Nervous System Disorder)\t(4R,9aS)-5-hydroxy-2-methyl-6,10-dioxo-3,4,6,9,9a,10-hexahydro-2H-1-oxa-4a,8a-diaza-anthracene-7-carboxylic acid- 2,4 difluorobenzylamide (Organic Chemical)\tPP (Hormones)\tMETAMYCE (Bone Marrow Cell Count Ratio Measurement)\tBranchio-otic syndrome (Hearing loss associated with syndrome)", + "output": "Neuritides, Peripheral (Non-Neoplastic Peripheral Nervous System Disorder)" + }, + { + "input": "Definition: RecQ Helicase Family Protein described as werner syndrome ATP-dependent helicase (1432 aa, ~162 kDa) is encoded by the human WRN gene. This protein plays a role in both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang.\nConcepts: meiotic cohesin complex (Cell Component)\tPODCI2-His/Her Health in General (Intellectual Product)\tCommunity (Intellectual Product)\tLignocaine HCl [anaesthesia] (Local anaesthetic allergens)\tEC 3.6.4.12 (Enzyme)", + "output": "EC 3.6.4.12 (Enzyme)" + }, + { + "input": "Definition: something described as a chromosome band present on 6q\nConcepts: 6q24-q25.1 (Chromosome band)\talkyne formation (organic substance biosynthetic process)\tprotein oligomer assembly (Molecular Function)\tCecostomy operations (Anastomosis of large intestine to large intestine)\tBlood monocyte (Peripheral blood mononuclear cell)", + "output": "6q24-q25.1 (Chromosome band)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in proteolysis and blood clotting.\nConcepts: astrocyte fate commitment (Cell Function)\tbullied (Mental or Behavioral Dysfunction)\tregulation of cell proliferation in mesencephalon (regulation of nervous system development)\tskeletal myofibril assembly (myofibril assembly)\tCOAGULATION FACTOR X (Peptidase Gene)", + "output": "COAGULATION FACTOR X (Peptidase Gene)" + }, + { + "input": "Definition: purine deoxyribonucleotide metabolic process described as the chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.\nConcepts: FAMITINIB (Organic Chemical)\tFamilial mesial temporal lobe epilepsy with febrile seizures (Hereditary disorder of nervous system)\tGastric Neuroendocrine Tumor pTX TNM Finding v7 (Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7)\tpurine deoxyribonucleotide catabolic process (Molecular Function)\tPhospholipase 2 Receptor Membranous Nephropathy (Membranous glomerulonephritis)", + "output": "purine deoxyribonucleotide catabolic process (Molecular Function)" + }, + { + "input": "Definition: Health Policy described as regulations to prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks.\nConcepts: Maximal voluntary ventilation (Finding)\tInternational Health Regulation (Health Policy)\tELLA (Laboratory Procedure)\tCDISC Questionnaire FACIT-Dyspnea 10 Item Short Form Test Code Terminology (Intellectual Product)\tIgG-HD37-SMPT-dgA (Immunologic Factor)", + "output": "International Health Regulation (Health Policy)" + }, + { + "input": "Definition: Measurement of substance described as a measurement of the fluvoxamine present in a biological specimen.\nConcepts: untreated childhood oligoastrocytoma (Untreated Central Nervous System Neoplasm)\tKLH-conjugated GM2 Ganglioside Vaccine (Cancer Vaccines)\tBenzodiones (Quinones)\tRetinoblastoma Pathologic Primary Tumor TNM Finding v8 (Retinoblastoma Pathologic TNM Finding v8)\tFluvoxamine measurement (Chemical procedure)", + "output": "Fluvoxamine measurement (Chemical procedure)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.\nConcepts: regulation of vasoconstriction by circulating adrenaline (regulation of vasoconstriction by epinephrine)\t1-deoxy-D-xylulose 5-phosphate metabolic process (phosphate-containing compound metabolic process)\tPowder for Suspension for Fish Treatment Dosage Form (Powder for Suspension Dosage Form)\tverruca plantaris (Verruca vulgaris of skin of lower extremity)\td.ng/ml/m2 (Quantitative Concept)", + "output": "1-deoxy-D-xylulose 5-phosphate metabolic process (phosphate-containing compound metabolic process)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.\nConcepts: Microcephalus, brain defect, spasticity, hypernatremia syndrome (Multiple system malformation syndrome)\t(All-Z)-7, 10, 13, 16, 19-docosapentaenoic Acid (Organic Chemical)\tglycogen metabolism (energy reserve metabolic process)\tstem cell factor receptor binding (Molecular Function)\tcytoplasmic side of rough endoplasmic reticulum membrane (Cell Component)", + "output": "stem cell factor receptor binding (Molecular Function)" + }, + { + "input": "Definition: Wounds, Penetrating described as disjoining the limbs or other parts of a corpse, often in association with criminal acts.\nConcepts: Dismemberment, Cadaver (Crime Act)\tRetinoblastoma pT3 TNM Finding v7 (Retinoblastoma Pathologic Primary Tumor TNM Finding v7)\tNSAA1-Climb Box Step - Right (Intellectual Product)\tAURC Infinity Pred Norm by Dose (Quantitative Concept)\tMIRLET7A3 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Dismemberment, Cadaver (Crime Act)" + }, + { + "input": "Definition: Disease Clinical Qualifier described as cancer that is likely to recur (come back), or spread.\nConcepts: Minute Times Milligram per Milliliter per Kilogram per Meter Squared (Measurement Unit Description)\thigh-risk cancer (Disease Clinical Qualifier)\tWhen people tell you the chance of something happening, do you prefer that they use words (\"it rarely happens\") or numbers (Clinical or Research Assessment Question)\tAcid, Aurin Tricarboxylic (Organic Chemical)\tIndole (tryptophan)", + "output": "high-risk cancer (Disease Clinical Qualifier)" + }, + { + "input": "Definition: something described as EEG with focal sharp transient waves in the occipital region, i.e., focal sharp waves of a duration less than 80 msec followed by a slow wave.\nConcepts: EEG with occipital focal spike waves (EEG with focal spike waves)\tdendritic transport (axo-dendritic transport)\tRadiographic unit (Diagnostic imaging equipment)\tCZECHIA (Country)\tOral Leukokeratosis (Oral Cavity and Lip Precancerous Condition)", + "output": "EEG with occipital focal spike waves (EEG with focal spike waves)" + }, + { + "input": "Definition: Simple physiological organic compound described as a histidine derivative that has a methyl group bound to the nitrogen at position 1 and results from the metabolism of the dipeptide anserine. Urinary levels of 1-methylhistidine may be indicative of myofibrillar protein degradation or a high protein diet.\nConcepts: myofiber development (striated muscle cell development)\tSTAMBP gene (Gene or Genome)\tPuerto Rico (Caribbean country)\t1-Methyl histidine (Amino Acid, Peptide, or Protein)\tHYPERPLASIAS (Growth and Maturation Alteration)", + "output": "1-Methyl histidine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as assisting clients/patients in a group setting in gaining weight. Service is billed in 60-minute increments per client.\nConcepts: Study Protocol Document Version Public Title Type Code (Intellectual Product)\tmesiodens tooth (Congenital Abnormality)\tSLOAN LETTER EYE CHART 100% (Ophthalmic examination and evaluation)\tEpstein-Barr Nuclear Antigen Antibody (LABORATORY IMMUNOLOGIC PROCEDURES)\twt gain asistnce grpea.h (Nutrition management)", + "output": "wt gain asistnce grpea.h (Nutrition management)" + }, + { + "input": "Definition: Dipeptidyl Peptidase-4 Inhibitor described as an orally available, potent, selective inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity. Compared to vildagliptin, anagliptin caused longer lasting inhibition of DPP-4 activity.\nConcepts: Unintended Power Up (Power Problem)\tDisk (Body Part, Organ, or Organ Component)\tReceptor, EphA6 (Receptors, Eph Family)\tcollagen type XIII trimer (Cell Component)\tanagliptin (Dipeptidyl Peptidase-4 Inhibitor)", + "output": "anagliptin (Dipeptidyl Peptidase-4 Inhibitor)" + }, + { + "input": "Definition: protein-containing complex described as a heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.\nConcepts: plaque forming unit (Quantitative Concept)\tposterior intralaminar thalamic nucleus (Body Part, Organ, or Organ Component)\ttranslocation and assembly module protein complex (Cell Component)\tLBORNRLO (Normal Range Lower Limit Original Unit)\tProduct, Incorrect (Finding)", + "output": "translocation and assembly module protein complex (Cell Component)" + }, + { + "input": "Definition: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor described as catalysis of the reaction: A [sulfatase]-L-cysteine + O(2) + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H(2)O.\nConcepts: detection of pH by aortic body chemoreceptor signalling (detection of pH by chemoreceptor signaling)\tCTX/5-FU/MTX/PRED/TMX (Therapeutic or Preventive Procedure)\tTelomere Homeostasis (Cell division)\tFormylglycine-generating oxidase activity (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor)\tVLP-encapsulated TLR9 agonist CMP-001 (Organic Chemical)", + "output": "Formylglycine-generating oxidase activity (oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor)" + }, + { + "input": "Definition: something described as a precancerous neoplastic process that affects the small or large intestine. It is characterized by low or high grade dysplasia of the mucosal epithelium. There is no evidence of invasion.\nConcepts: CSS03-Number of Interrupted Attempts (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tIntestinal Dysplasia (Intestinal Precancerous Condition)\torganized labor (Organization administrative structures)\tMacrophage Inflammatory Protein-2 (Laboratory Procedure)\tSmall epiphysis of the proximal phalanx of the 4th finger (Abnormality of the epiphysis of the proximal phalanx of the 4th finger)", + "output": "Intestinal Dysplasia (Intestinal Precancerous Condition)" + }, + { + "input": "Definition: Quantitative Concept described as the final aggregate amount.\nConcepts: Sibling Relations (Social Behavior)\tpinene synthase activity (Molecular Function)\tSum (Quantitative Concept)\tNP 004295.2:p.Phe1245Xxx (ALK Protein Variant)\tGrade 4 Feeding Intolerance, Adverse Event (Finding)", + "output": "Sum (Quantitative Concept)" + }, + { + "input": "Definition: something described as common name for fish of the family Ostraciitae.\nConcepts: FAMILY OSTRACIIDAE - BOXFISHES (Fish)\turea metabolism (small molecule metabolic process)\tMethods, Kangaroo-Mother Care (Positioning patient)\tNE (US State)\tGroup III intron splicing (Genetic Function)", + "output": "FAMILY OSTRACIIDAE - BOXFISHES (Fish)" + }, + { + "input": "Definition: nitric oxide binding described as interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO).\nConcepts: NO sensor activity (small molecule sensor activity)\tkorsakoff psychosis (Psychoses, Drug)\tTemporary Epidural Catheter Placement (Epidural Anesthesia)\tPregnancy Related Skin Change (Sign or Symptom)\tRetinoblastoma Pathologic Regional Lymph Nodes TNM Finding v7 (Retinoblastoma Pathologic TNM Finding v7)", + "output": "NO sensor activity (small molecule sensor activity)" + }, + { + "input": "Definition: Organism Attribute described as the length of a person's life, stated in months since birth.\nConcepts: reperfusion therapy (Perfusion)\tAge-Months (Age)\tHypoxias, Tumor Cell (Cell Hypoxia)\tINFECTION FUNGAL (Disease or Syndrome)\tHAIP (Medical Device)", + "output": "Age-Months (Age)" + }, + { + "input": "Definition: Subdivision Ustilaginomycotina described as an order of basidiomycetous fungi; some species are parasitic on grasses (POACEAE) and maize.\nConcepts: anal (Gastrointestinal system)\tsmut (Ustilaginales)\tALESTRAMUSTINE (Pharmacologic Substance)\tfructose-1-phosphatase activity (Molecular Function)\tJoin Code (Intellectual Product)", + "output": "smut (Ustilaginales)" + }, + { + "input": "Definition: Enhancer Elements, Genetic described as cis-acting regulatory sequences in the HIV long terminal repeat (LTR) which play a major role in induction or augmentation of HIV gene expression in response to environmental stimuli such as mitogens, phorbol esters, or other viruses. The HIV enhancer is the binding site for many cellular transcription factors including the nuclear factor NF-kappa B.\nConcepts: Balances, Mechanical, Analytic (Analytical balance)\tCMC5 (Carpometacarpal joint structure)\tHIV Enhancers (Nucleic Acid, Nucleoside, or Nucleotide)\tTrue nearly all the time (How True)\tBiological Carcinogenesis (Biomedical Occupation or Discipline)", + "output": "HIV Enhancers (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: something described as the symptoms of neck stiffness, headache, and photophobia resulting from meningeal irritation.\nConcepts: VP14 (carotenoid dioxygenase activity)\tAwls, Cartilage, Nasal (Medical Device)\tOxidation-Reduction Potential (Physical Phenomenon or Property)\tATLAS - Treatment With Antibiotics (Intellectual Product)\tpseudomeningitis (BRAIN IRRITATION)", + "output": "pseudomeningitis (BRAIN IRRITATION)" + }, + { + "input": "Definition: something described as any one of the seven vertebrae that start with C1, connecting the skull to the spine, and ends with C7, which joins the cervical with the thoracic spine.\nConcepts: Fibular metaphyseal irregularity (Anatomical Abnormality)\tCervical vertebrae (Cervical Vertebrae)\tpostcentral sensory area (Body Part, Organ, or Organ Component)\tpositive regulation of photosynthesis (positive regulation of cellular metabolic process)\tCURI complex location (protein-containing complex)", + "output": "Cervical vertebrae (Cervical Vertebrae)" + }, + { + "input": "Definition: Nucleus of spinal nerve described as spinal nerve nucleus located in the thoracic region of spinal cord.\nConcepts: Lumbar platyspondyly (Platyspondyly)\t1q41-q42 (Chromosome band)\tLog10 Colony Forming Units per Gram (Unit of Arbitrary Substance Concentration)\tThoracic spinal nerve soma group (Body Location or Region)\tPQL11TN (CDISC Questionnaire Terminology)", + "output": "Thoracic spinal nerve soma group (Body Location or Region)" + }, + { + "input": "Definition: something described as an inorganic or organic molecule which binds metal ions. Metal chelators are frequently polydentate, indicating that they form multiple bonds with the metal ion, resulting in more stable coordination complexes.\nConcepts: 351 TRICUSPID VALVE (Entire heart valve)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycobacterium avium Complex, rRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycobacterium avium, rRNA)\tMetal Chelator (Chelating Agents)\tCELF2 gene (Gene or Genome)\tCASP7 protein (caspase)", + "output": "Metal Chelator (Chelating Agents)" + }, + { + "input": "Definition: Pharmacologic Substance described as an antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells.\nConcepts: carboxymethyloxysuccinate glycolate-lyase (Molecular Function)\tGrade 3 Sinus disorder (Finding)\tNasal Cavity and Paranasal Sinuses Cancer cM1 TNM Finding v8 (Finding)\tmethyl 5-acetylamino-6,7-dihydro-9,10,11-trimethoxy-5H-dibenzo(a,c)cycloheptene-3-carboxylate (Pharmacologic Substance)\tformin-nucleated actin cable organization (actin filament bundle organization)", + "output": "methyl 5-acetylamino-6,7-dihydro-9,10,11-trimethoxy-5H-dibenzo(a,c)cycloheptene-3-carboxylate (Pharmacologic Substance)" + }, + { + "input": "Definition: HLA-DRB3 & HLA-DRB4 & HLA DRB5 described as a subtype of HLA-DRB beta chains that includes over 50 allelic variants. The HLA-DRB3 beta-chain subtype is associated with HLA-DR52 serological subtype.\nConcepts: Knock-in (Organism Modification)\tConcomitant Medication Reason Not Collected (Not-Done Reason)\tGadolinium-Based Nanoparticle (Organic Chemical)\tHLA DRB3 Chains (HLA-DRB3 & HLA-DRB4 & HLA DRB5)\tPostnatal growth failure (Weight)", + "output": "HLA DRB3 Chains (HLA-DRB3 & HLA-DRB4 & HLA DRB5)" + }, + { + "input": "Definition: something described as brief Pain Inventory - Are you having problems with side effects from your pain medication?\nConcepts: intrinsic to endosome membrane (Cell Component)\tField Survey (Population Study)\tEthanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1) (NMDA receptor antagonist)\tCROWN AND BRIDGE, TEMPORARY, RESIN (Biomedical or Dental Material)\tBPI1-Problems with Side Effects Pain Med (Intellectual Product)", + "output": "BPI1-Problems with Side Effects Pain Med (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of osteoblast differentiation.\nConcepts: amygdalostriatal transition area (Body Location or Region)\tPalbociclib Regimen (Regimen Used to Treat Breast Carcinoma)\tShields, Mechanical, Eye, Collagen (Medical dressing)\tupregulation of osteoblast differentiation (regulation of osteoblast differentiation)\tlymphadenopathy; angioimmunoblastic (Neoplasm, uncertain whether benign or malignant)", + "output": "upregulation of osteoblast differentiation (regulation of osteoblast differentiation)" + }, + { + "input": "Definition: Follicular keratosis described as a very common, non-neoplastic dermatologic disorder characterized by keratinization of hair follicles of the skin. It manifests as small, rough folliculocentric keratotic papules, usually in the outer-upper arms and thighs. It affects children and adolescents and usually improves with age.\nConcepts: Keratosis pillaris (Hyperkeratosis)\tAlleles (Genetic finding)\tmodulation of biological quality in other organism (modulation of process of other organism)\tIVD Test Reagent/Kits, Immunoassay, Toxicology, Antidepressant, Protriptyline (IVD Test Reagent/Kits, Immunoassay, Toxicology, Antidepressant)\tnegative regulation of cytokinesis, actomyosin contractile ring assembly (negative regulation of cytokinesis)", + "output": "Keratosis pillaris (Hyperkeratosis)" + }, + { + "input": "Definition: cellular anatomical entity described as a cell part consisting of multiple, closely packed actin-based cell projections.\nConcepts: Cutaneous Squamous Cell Carcinoma of the Head and Neck cN3b TNM Finding v8 (Finding)\tAbsent/small lower limb bones (Finding)\tSevere intellectual disability, short stature, behavioural abnormalities, facial dysmorphism syndrome (Dwarfism)\tTranscription Factor ETV6/Beta-Type Platelet-Derived Growth Factor Receptor Fusion Protein (Fusion protein)\tcluster of actin-based cell projections (Cell Component)", + "output": "cluster of actin-based cell projections (Cell Component)" + }, + { + "input": "Definition: Implantation Site Characterization described as an implantation site that contains no discernible embryonic or placental tissue but may contain remnants of the implantation.\nConcepts: EMPTY IMPLANTATION SITE (Finding)\tCMSTDTC (Observation Start Date Time)\tGrade 2 Bladder spasms (Finding)\tRaf/MEK Serine/Threonine Kinase Inhibitor RO5126766 (Pharmacologic Substance)\tnegative regulation of release of cytochrome c from mitochondria (negative regulation of apoptotic signaling pathway)", + "output": "EMPTY IMPLANTATION SITE (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human TSLP wild-type allele is located in the vicinity of 5q22.1 and is approximately 5 kb in length. This allele, which encodes thymic stromal lymphopoietin protein, plays a role in hematopoiesis and chemotaxis.\nConcepts: Rater 1 (Professional or Occupational Group)\tTSLP wt Allele (Gene or Genome)\tPleuropericardial Membrane (Embryonic Structure)\tmale germ cell proliferation (Cell Function)\tBenign nocturnal alternating hemiplegia of childhood (Alternating hemiplegia of childhood)", + "output": "TSLP wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Abnormality of the ribs described as a physical quality in which the rib is undulating.\nConcepts: Undulate ribs (Ribs, sternum, clavicles, and scapulae)\tTrans-Tibial Prostheses, External Component (Medical Device)\tEunuchoid habitus (Finding)\tchylomicron (plasma lipoprotein particle)\tStructure of retinal pigment epithelium (Body Part, Organ, or Organ Component)", + "output": "Undulate ribs (Ribs, sternum, clavicles, and scapulae)" + }, + { + "input": "Definition: Concept described as a terminology concept modeled in a structured and formally well-understood way using logic-based semantics which can be given by a translation into first-order predicate logic.\nConcepts: up-regulation of chaperone-mediated autophagy (positive regulation of autophagy)\tANGIOLIPOMATOSIS, FAMILIAL (Disease or Syndrome)\tGum Arabic (Organic Chemical)\tEmbryo at Carnegie stage 14 (Embryonic Structure)\tDesc Logic Concept (Concept)", + "output": "Desc Logic Concept (Concept)" + }, + { + "input": "Definition: Intellectual Product described as a rating scale included in the Pediatric Quality of Life Inventory Version 4 (PedsQL 4.0) that measures problems with a child's physical health and activities.\nConcepts: cellular response to cyclosporin A (response to cyclosporin A)\tEosinophils/Total Cells (Blood Cell Count Ratio Measurement)\tPhysical Functioning Scale (Research or Clinical Assessment Tool)\tIVD Test Reagent/Kits, Immunoassay, Calibration, Vitamin (Medical Device)\tOptical Distortion (Finding)", + "output": "Physical Functioning Scale (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as a measurement of the eotaxin-1 in a biological specimen.\nConcepts: Microdialysis (Physical Dialysis)\tresponse to fatty acid (response to lipid)\tEotaxin-1 Measurement (Chemokine Measurement)\tdiphosphonate (Organic Chemicals)\tCentral Nervous System Leiomyoma (Benign Central Nervous System Mesenchymal, Non-Meningothelial Neoplasm)", + "output": "Eotaxin-1 Measurement (Chemokine Measurement)" + }, + { + "input": "Definition: Female Genital Diseases described as a benign, precancerous, or malignant neoplasm that affects the female reproductive system. Representative examples include uterine corpus leiomyoma, endocervical polyp, ovarian carcinoma, cervical carcinoma, and endometrial carcinoma.\nConcepts: TPM3 Gene Product (Cytoskeletal Proteins)\tFemale reproductive neoplasm (Genitourinary Neoplasms)\tContraceptive device (Medical Devices)\tregulation of lipid binding (Molecular Function)\tcentral nervous system maturation (Organ or Tissue Function)", + "output": "Female reproductive neoplasm (Genitourinary Neoplasms)" + }, + { + "input": "Definition: Helpessness described as exposure to adverse and uncontrollable events often causes the reaction of helplessness; symptoms include: difficulty in learning behavior patterns in reaction to controllable adversities, reduced motivation in initiating coping responses, and emotional reactions of sadness or depression.\nConcepts: Benign Unclassifiable Tumor (oncologic disorders)\tNucleus supraopticus hypothalami (Hypothalamus, Anterior)\tPALB2 Mutation Analysis (Laboratory Procedure)\tlearned helplessness (Helpessness)\tCSF RBC Count (Red Blood Cell Count measurement)", + "output": "learned helplessness (Helpessness)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an alanine amino transferase (ALT/SGPT) test system is a device intended to measure the activity of the enzyme alanine amino transferase (ALT) (also known as a serum glutamic pyruvic transaminase or SGPT) in serum and plasma. Alanine amino transferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases.\nConcepts: Transglycosylase (Enzyme)\tCordonnier Bacterial Complication (Cordonnier Infectious Complications Grading Scale)\tOrganelle structure (cellular anatomical entity)\tDIAZO, ALT/SGPT (Indicator, Reagent, or Diagnostic Aid)\tPhysiologic Psychology (Psychobiology)", + "output": "DIAZO, ALT/SGPT (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as micrograms per milliliter (concentration), divided by meters squared (surface area).\nConcepts: Microgram per Milliliter per Meter Squared (Unit of concentration)\tSacral Nerve Stimulator (Medical Device)\tSodium-Glucose Transporter 1 (Biologically Active Substance)\tcramps muscles (Systemic Toxin Clearance: Dialysis)\tInstitutional Ethics (Idea or Concept)", + "output": "Microgram per Milliliter per Meter Squared (Unit of concentration)" + }, + { + "input": "Definition: polysaccharide metabolic process described as the chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues.\nConcepts: arabinan metabolic process (polysaccharide metabolic process)\tresponse to salicylic acid stimulus (response to organic cyclic compound)\tdorsomedial hypothalamic nucleus, anterior part (Body Part, Organ, or Organ Component)\tepigastric; pain (Upper abdominal pain)\tSerum Phosphate Measurement (Laboratory Procedure)", + "output": "arabinan metabolic process (polysaccharide metabolic process)" + }, + { + "input": "Definition: something described as a ureteral stone dislodger is a device that consists of a bougie or a catheter with an expandable wire basket near the tip, a special flexible tip, or other special construction. It is inserted through a cystoscope and used to entrap and remove stones from the ureter. This generic type of device includes the metal basket and the flexible ureteral stone dislodger.\nConcepts: Branchiura (Class Maxillopoda)\tR-HD-MTX/ARA-C (Regimen Used to Treat Non-Hodgkin Lymphoma)\tAfraid to be Far from a Toilet (Clinical or Research Assessment Question)\tDISLODGER, STONE, FLEXIBLE (Medical Device)\tIVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Antiglobulin, Polyspecific (IVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Antiglobulin)", + "output": "DISLODGER, STONE, FLEXIBLE (Medical Device)" + }, + { + "input": "Definition: SMN Complex Proteins described as an SMN complex protein that contains a TUDOR DOMAIN and is essential for the function of the SMN protein complex. In humans, the protein is encoded by a single gene found near the inversion TELOMERE of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.\nConcepts: Adult elemental anti-inflammatory GI intolerance critical care specialty formula (Adult elemental formula)\tleukemia, acute (Neoplastic Process)\tSugar, Blood (Body Fluids)\tMannose Receptor, C Type 1 (Amino Acid, Peptide, or Protein)\tSurvival of Motor Neuron 1 Protein (SMN Complex Proteins)", + "output": "Survival of Motor Neuron 1 Protein (SMN Complex Proteins)" + }, + { + "input": "Definition: Molecular Analysis described as a test that measures the gene expression profile in a removed tissue sample that contains ductal carcinoma in situ (DCIS). The result is reported as DCIS score and is used for treatment decisions tailored to the specific patient and to calculate the chances of recurrence.\nConcepts: DCIS Score (Laboratory Procedure)\tCDISC SDTM Coronary Artery Disease Presentation Terminology (Intellectual Product)\tIVD Test Reagent/Kits, Home Assay, Whole Blood, Sampling (IVD Test Reagent/Kits, Home Assay, Whole Blood)\tregulation of inward rectifier potassium channel activity (regulation of potassium ion transmembrane transporter activity)\tPostpartal care (Woman)", + "output": "DCIS Score (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a response of 1 on an illness intrusiveness scale that ranges from 1: Not Very Much to 7: Very Much.\nConcepts: slingshot homolog 1 (Protein Phosphatase Gene)\tTsetse Fly (Eukaryote)\tanti-HER2-CAR-engineered NK-92/5.28.z cells (Cell)\tMASKED (Missing Value Reason)\t1 (Illness Intrusiveness Ratings Scale)", + "output": "1 (Illness Intrusiveness Ratings Scale)" + }, + { + "input": "Definition: Mental Process described as feeling or showing sorrow; the sense of being unhappy. It is related to DEPRESSION but is not synonymous.\nConcepts: sadness (Level of depression)\tVitamin B-3 (Nicotinic acid and derivatives, lipid modifying, plain)\tPropionicibacterium avidum (P [Preparations])\tcrotonyl-CoA hydratase activity (hydro-lyase activity)\tAPCH110 (Intellectual Product)", + "output": "sadness (Level of depression)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the larger chamber on the left side of the heart, which receives oxygenated blood from the left atrium and pumps it through the aortic valve into the aorta.\nConcepts: 326 LEFT VENTRICLE (Left ventricular structure)\tCongenital ankylosis of temporomandibular joint (Congenital anomaly of jaw)\tObliterative portal venopathy (Disorder of hepatic portal vein)\tI feel lightheaded (Intellectual Product)\tSqualus (Squalidae)", + "output": "326 LEFT VENTRICLE (Left ventricular structure)" + }, + { + "input": "Definition: Property or Attribute described as an indication that the subject has fulfilled the criteria needed to continue to the next study period.\nConcepts: ecgonine methyl ester biosynthesis (Molecular Function)\tIVD Test Reagent/Kits, Hematology, Control, Whole Blood (Medical Device)\tELIGIBILITY CRITERIA MET (Property or Attribute)\tdown-regulation of retina development in camera-style eye (Physiologic Function)\tInfluenza-Specific Culture (Culturing, In Vitro Microbial)", + "output": "ELIGIBILITY CRITERIA MET (Property or Attribute)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA.\nConcepts: Colorectal Carcinoma Metastatic in the Liver (Metastatic Colorectal Carcinoma)\tAnti-Integrin Monoclonal Antibody-DM4 Immunoconjugate IMGN388 (Antineoplastic Antibody-Drug Conjugate)\tthalictroides, Caulophyllum (Plant)\tsnoRNA metabolic process (ncRNA metabolic process)\tProduct containing cetuximab (Antineoplastic Antibody)", + "output": "snoRNA metabolic process (ncRNA metabolic process)" + }, + { + "input": "Definition: Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v7 described as major salivary gland cancer with metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension.\nConcepts: cardiovascular disorder epidemiology (Occupation or Discipline)\tMajor Salivary Gland Cancer pN1 TNM Finding (Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v6)\tCUTANEOUS SPRAY, SUSPENSION (Cutaneous AND/OR transdermal dosage form)\tUniform Resource Identifier (Intellectual Product)\tCarcinoma of the Conjunctiva pT4d TNM Finding v7 (Finding)", + "output": "Major Salivary Gland Cancer pN1 TNM Finding (Major Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v6)" + }, + { + "input": "Definition: Drug allergens described as a gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.\nConcepts: echoPlanarPulseSequenceIndicator (Indicator)\tTechnetium Tc-99m Medronate (Indicator, Reagent, or Diagnostic Aid)\tdorsal 3rd ventricle (Body Part, Organ, or Organ Component)\tregulation of NLRP3 inflammasome complex assembly (Cell Function)\tpositive regulation of cytokine production involved in immune response (Organism Function)", + "output": "Technetium Tc-99m Medronate (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Hydrocarbons described as colorless, odorless, inflammable gas, CH4, produced by decomposition of organic matter, which may explode when mixed with air or oxygen; the first member of a homologous series of saturated hydrocarbons, including ethane, propane, and butane.\nConcepts: Receptor, G-CSF (Receptors, Colony-Stimulating Factor)\tmethane (Alkanes)\tPerformed Imaging Study (imaging studies)\tup-regulation of 3'-untranslated region-mediated mRNA stabilization (positive regulation of gene expression)\tCT45.2 (Gene or Genome)", + "output": "methane (Alkanes)" + }, + { + "input": "Definition: Denominators of time described as a rate of occurrences within a period of time equal to one hour.\nConcepts: Power, Loss Of (Finding)\tPost-Transcriptional Regulation Process (Genetic Function)\tMdm 2 Protein (Nuclear Proteins)\t/hour (Temporal Concept)\tQuestion mark ears (Finding)", + "output": "/hour (Temporal Concept)" + }, + { + "input": "Definition: Organ component of radius described as long bone, each instance of which articulates with some humerus, ulna, lunate and scaphoid.\nConcepts: Cell membrane structure (Plasma membrane)\tHFE-transferrin receptor complex (plasma membrane signaling receptor complex)\tIWG-MRT Myelofibrosis Spleen Response (IWG-MRT Criteria for Treatment Response in Myelofibrosis)\tbones radius (Body part)\tMethylhistidines (Amino Acid, Peptide, or Protein)", + "output": "bones radius (Body part)" + }, + { + "input": "Definition: Nasal Cavity and Paranasal Sinus Neoplasm described as melanoma that arises from the mucosal surface of the nasal cavity and paranasal sinus.\nConcepts: Sinonasal Melanoma (Mucosal Melanoma of the Head and Neck)\tWHEELCHAIR, STANDUP (Medical Device)\tEuphorbiaceae (Wild flowers)\tEar spray emulsion (Otic dosage form)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Light Chain (Medical Device)", + "output": "Sinonasal Melanoma (Mucosal Melanoma of the Head and Neck)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving a fatty acid which has a chain length greater than C22.\nConcepts: Total mastectomy NOS (Procedures on breast)\tIntravenous Solution Storage Cabinets, Pole-Mounted (Manufactured Object)\tREAGENT, IMMUNOASSAY, IGG (Medical Device)\t3-Methylglutaconicaciduria (Abnormality of mitochondrial metabolism)\tvery long chain fatty acid metabolic process (Fatty Acid Metabolism Pathway)", + "output": "very long chain fatty acid metabolic process (Fatty Acid Metabolism Pathway)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as viral proteins that facilitate the movement of viruses between plant cells by means of PLASMODESMATA, channels that traverse the plant cell walls.\nConcepts: Step Relative (Family Group)\tMovement Proteins, Virus, Plant (Viral Structural Proteins)\tIVD Test Reagent/Kits, Molecular Assay, Immunology (Medical Device)\tWear Special Eyewear or Scleral Lenses to Relieve Eye Pain (Intellectual Product)\tperfluoroctylbromide (Other magnetic resonance imaging contrast media in ATC)", + "output": "Movement Proteins, Virus, Plant (Viral Structural Proteins)" + }, + { + "input": "Definition: C-SSRS Screening Questionnaire Question described as columbia-Suicide Severity Rating Scale Screening - Total number of actual attempts.\nConcepts: Cardiotrophin 1 wt Allele (Gene or Genome)\tNonconformance to editorial policy component (Concept inactivation value)\tphosphocreatine metabolic process (Molecular Function)\tC-SSRS Screening - Number of Actual Suicide Attempts (Intellectual Product)\tdetermination of adaxial/abaxial asymmetry (Organism Function)", + "output": "C-SSRS Screening - Number of Actual Suicide Attempts (Intellectual Product)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the myotubular myopathy 1 (MTM1) gene, located at chromosome Xq28, which encodes for a lipid phosphatase required for muscle cell differentiation. Mutations at this locus have been identified in patients with X-linked myotubular myopathy type 1 (also called X-linked centronuclear myopathy).\nConcepts: ovarian follicle cell adhesion (epithelial cell-cell adhesion)\tmmol/sec (Unit of Dose Calculation)\tPQL0803 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MTM1 (Medical Device)\tTotal CL Pred by F (Quantitative Concept)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MTM1 (Medical Device)" + }, + { + "input": "Definition: Paraphilias and paraphilic disorders described as sexual urges, fantasies, or behaviors generally involving themes of suffering, humiliation, sexual activity with non-consenting partners, or an orientation toward non-human objects for sexual arousal.\nConcepts: Paraphilic Disorders (Psychosexual Behavior)\tB-Cells, Regulatory (Cell)\t46,xy gonadal dysgenesis (Gonadal Dysgenesis)\tRecurrent Ph-Like Acute Lymphoblastic Leukemia (Ph-Like Acute Lymphoblastic Leukemia)\tChecked-Out (Qualitative Concept)", + "output": "Paraphilic Disorders (Psychosexual Behavior)" + }, + { + "input": "Definition: something described as a myopathy that was caused by a primary disorder of glycogen storage.\nConcepts: Natural Cytotoxicity Receptor (Protein Family)\tA2B Receptors, Adenosine (Amino Acid, Peptide, or Protein)\tVirus, Abelson Leukemia (unclassified Gammaretrovirus)\tGlycogen storage disorder (Other Finding)\tIVD Panels, Human Genetics, Neuromuscular Disorder, Spinal Muscular Atrophy, Comprehensive, Mutation (IVD Panels, Human Genetics, Neuromuscular Disorder, Spinal Muscular Atrophy, Comprehensive)", + "output": "Glycogen storage disorder (Other Finding)" + }, + { + "input": "Definition: something described as compounds with three contiguous nitrogen atoms in linear format R2N-N=NR.\nConcepts: Poliovirus Receptor-Like 4 Positive (Laboratory or Test Result)\tSA nodal myocyte (Nodal myocyte)\tNightmare Disorder (Mental or Behavioral Dysfunction)\tCompounds, Diazoamino (Organic Chemical)\tLower Extensor Surface (Body Location or Region)", + "output": "Compounds, Diazoamino (Organic Chemical)" + }, + { + "input": "Definition: Statistical Imputation described as the substitution of missing data with the most recent data collected that is not missing.\nConcepts: Flexor digitorum longus (Skeletal muscle structure of lower leg)\tLabels, Spin (Indicator, Reagent, or Diagnostic Aid)\tguanidinodeoxy-scyllo-inositol-4-phosphatase activity (Molecular Function)\tReceptor Tyrosine Kinase-Like Orphan Receptor 1 Gene (Receptor Tyrosine Kinase Gene)\tLast Observation Carried Forward Imputation Technique (Statistical Imputation)", + "output": "Last Observation Carried Forward Imputation Technique (Statistical Imputation)" + }, + { + "input": "Definition: Finding described as a facial appearance characteristic of myopathic conditions. The face appears expressionless with sunken cheeks, bilateral ptosis, and inability to elevate the corners of the mouth, due to muscle weakness.\nConcepts: breast intraductal papilloma (Papilloma, Intraductal)\tDeoxyhemoglobin Measurement (Laboratory Procedure)\tL-tyrosine:2-oxoglutarate aminotransferase activity (L-tyrosine aminotransferase activity)\tMyopathic face (Finding)\tqiaos, Lian (Forsythieae)", + "output": "Myopathic face (Finding)" + }, + { + "input": "Definition: Scrotal Infection, CTCAE described as localized, local intervention indicated\nConcepts: Grade 1 Scrotal infection (Finding)\tSigmund Freud (Human)\tpositive regulation of cobalamin metabolic process (positive regulation of tetrapyrrole metabolic process)\tQIDSR1-View of Myself (QIDS-SR Questionnaire Question)\tI have had to work really hard to pay attention or I would make a mistake (Clinical or Research Assessment Question)", + "output": "Grade 1 Scrotal infection (Finding)" + }, + { + "input": "Definition: Relationships described as the relationship of an event to a device, which may or may not be a device under study.\nConcepts: Hospital Medical Record Obtained Indicator (Conceptual Entity)\tRLDEV (Functional Concept)\tElectrode, device (Reusable Devices)\tEscherichia coli k12 (Bacterium)\tzantac (Branded drug names Z)", + "output": "RLDEV (Functional Concept)" + }, + { + "input": "Definition: German translation of the Medical Subject Headings described as minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane; cells are the fundamental, structural, and functional units of living organisms.\nConcepts: Mean (Numerical descriptors)\tregulation of humoral immune response mediated by circulating immunoglobulin (regulation of humoral immune response)\tLEPTOSPIRA (ORDER SPIROCHAETALES)\tplastid mRNA editing complex (Cell Component)\tCellular structures (Measureable Entity)", + "output": "Cellular structures (Measureable Entity)" + }, + { + "input": "Definition: Organism Function described as the specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers.\nConcepts: EXACT1-Tired or Weak (EXACT Questionnaire Question)\tUnspecified cells (Cell Fraction)\tAdjusted Bonferroni Method (Quantitative Concept)\tEyes Dry or Gritty (Clinical or Research Assessment Question)\tembryo shoot apical meristem specification (embryonic meristem initiation)", + "output": "embryo shoot apical meristem specification (embryonic meristem initiation)" + }, + { + "input": "Definition: Piperidine derivative described as a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis.\nConcepts: Zero Full Term Pregnancies (Number of Full Term Pregnancies)\t(\u00b1)-thalidomide (T [Preparations])\tCoated Pellet in Capsule Dose Form (Oral Capsule)\tGondi language (Dravidian language)\tFree Tau Protein Measurement (Laboratory Procedure)", + "output": "(\u00b1)-thalidomide (T [Preparations])" + }, + { + "input": "Definition: Application described as television advertisements submitted to FDA for pre-dissemination review in compliance with section 503B of the Federal Food, Drug, and Cosmetic Act.\nConcepts: demethylsterigmatocystin methyltransferase activity (O-methyltransferase activity)\ttype A/type B personality (Personality)\tPromotional 503b (Intellectual Product)\tWD6D1 4 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)\tProximal Volar (Anatomy Qualifier)", + "output": "Promotional 503b (Intellectual Product)" + }, + { + "input": "Definition: public health medicine described as demographic and epidemiologic changes that have occurred in the last five decades in many developing countries and that are characterized by major growth in the number and proportion of middle-aged and elderly persons and in the frequency of the diseases that occur in these age groups. The health transition is the result of efforts to improve maternal and child health via primary care and outreach services and such efforts have been responsible for a decrease in the birth rate; reduced maternal mortality; improved preventive services; reduced infant mortality, and the increased life expectancy that defines the transition. (From Ann Intern Med 1992 Mar 15;116(6):499-504)\nConcepts: Interleukin 3 Measurement (Laboratory Procedure)\tRelation, Dental Centric (Jaw Relation Record)\tobsolete Abnormal concentration of calcium in blood (Abnormal blood inorganic cation concentration)\tHealth transition (Population Dynamics)\tSialylated Lewis a Antigen (Antigens, Tumor-Associated, Carbohydrate)", + "output": "Health transition (Population Dynamics)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an alteration in a gene that is present for the first time in one family member as a result of a mutation in a germ cell (egg or sperm) of one of the parents, or a mutation that arises in the fertilized egg itself during early embryogenesis.\nConcepts: primary sclerosing cholangitis (Cholangitis)\tglutamate breakdown to oxaloacetate (glutamate catabolic process)\tNPS - Tell Us How Sensitive Your Skin is to Light Touch or Clothing (NPS Questionnaire Question)\tde novo mutation (Mutation Abnormality)\tHeller's Myotomy (Digestive System Surgical Procedures)", + "output": "de novo mutation (Mutation Abnormality)" + }, + { + "input": "Definition: Finding described as severe pain; limiting self care ADL\nConcepts: regulation of Hulle cell development (regulation of cell development)\tGrade 3 Breast Pain, CTCAE (Breast Pain, CTCAE 5.0)\tLaryngeal edema (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tLKLF (Gene or Genome)\tproteinoplast (Cell Component)", + "output": "Grade 3 Breast Pain, CTCAE (Breast Pain, CTCAE 5.0)" + }, + { + "input": "Definition: Health Care Related Organization described as NCI meetings on state-of-the-art or emerging technologies\nConcepts: upregulation of mRNA metabolic process (Genetic Function)\tJoining Organizations with Leading Technologies (Professional Organization or Group)\tMycolicibacter terrae (Wayne 1966) Gupta et al. 2018 (Mycobacterium terrae complex)\tASIC Channel (Sodium Channel)\tACAD3 (ACADS gene)", + "output": "Joining Organizations with Leading Technologies (Professional Organization or Group)" + }, + { + "input": "Definition: Xanthine or xanthine derivative described as a plant genus of the family RUBIACEAE. It is best known for the COFFEE beverage prepared from the beans (SEEDS).\nConcepts: Coffea (Rubiaceae)\tAppropriate Placental Villous Maturation (Placental finding)\tRefractory Cytopenia with Multilineage Dysplasia (Neoplastic Process)\tDistrito Federal of Mexico (Geographic Area)\tAbnormal platelet ATP dense granule secretion (Abnormal platelet dense granule secretion)", + "output": "Coffea (Rubiaceae)" + }, + { + "input": "Definition: something described as the infusion of plasma into the bloodstream.\nConcepts: pineocytomas (Neoplastic Process)\tInfections, Filarioidea (Filariasis)\ttransfusion plasma (Transfusion)\tSiglecs (Receptor)\tPositive Airway Pressure Therapies (Therapeutic or Preventive Procedure)", + "output": "transfusion plasma (Transfusion)" + }, + { + "input": "Definition: Gene or Genome described as human APOE*4 allele is located in the vicinity of 19q13.2 and is approximately 4 kb in length. This allele, which encodes apolipoprotein E4, plays a role in triglyceride metabolism. The allele is associated with increased occurrence of both Alzheimer disease and coronary artery disease.\nConcepts: APOE4 Allele (Gene or Genome)\tUrinary tract function, NOS (Biological Processes)\tAcquired resp distress syndrom (Other respiratory diseases principally affecting the interstitium)\tMONITOR, AIR EMBOLISM, ULTRASONIC (Medical Device)\tBreast Cancer pN2a TNM Finding v8 (Finding)", + "output": "APOE4 Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles.\nConcepts: regulation of multivesicular body size (regulation of endosome size)\tUlnar-mammary syndrome (Anomaly of chromosome pair 12)\tdelamination (Negative Regulation of Cell-Cell Adhesion)\tCD2AP gene (Gene or Genome)\toxygen binding (small molecule binding)", + "output": "regulation of multivesicular body size (regulation of endosome size)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Carrying something weighing 10-20 lbs (about 4.5-9kg, like a large bag of groceries) from one room to another.\nConcepts: FAC10017 (Intellectual Product)\tregulation of cell morphogenesis of phenotypic switching (Biologic Function)\tFAC070-Trouble Starting Things (FACIT-Fatigue 13-Item Version 4 Questionnaire Question)\tHypotonic Cerebral Palsies (Non-spastic cerebral palsy)\tNecrotizing Funisitis (Funisitis)", + "output": "FAC10017 (Intellectual Product)" + }, + { + "input": "Definition: UPDRS Questionnaire Question described as unified Parkinson's Disease Rating Scale - Activities of daily living sub-total.\nConcepts: Cutaneous Neuroendocrine Carcinoma pN1b TNM Finding v7 (Finding)\tUPD1-Activities Daily Living Sub-Total (UPDRS Questionnaire Question)\tRenal failure unspecified (Decreased renal function)\tProduct containing carbohydrate (Caloric agent)\tmitochondria-nucleus signal transduction (Cell Function)", + "output": "UPD1-Activities Daily Living Sub-Total (UPDRS Questionnaire Question)" + }, + { + "input": "Definition: response to cation stress described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment.\nConcepts: SEXUAL PRECOCITY, FAMILIAL, GONADOTROPIN-INDEPENDENT (Congenital anomaly of endocrine testis)\tHigh energy enteral formula (Adult high energy formula)\tHomotypic cortex (Body Part, Organ, or Organ Component)\tcellular response to cation stress (cellular response to salt stress)\tGallbladder Carcinoma pTis TNM Finding v8 (Gallbladder Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "cellular response to cation stress (cellular response to salt stress)" + }, + { + "input": "Definition: something described as proteins found in blood, milk, etc.\nConcepts: globulin (Serum Proteins)\tphosphonate-transporting ATPase activity (Molecular Function)\tphytanate-CoA ligase activity (acid-thiol ligase activity)\tCep170B (Biologically Active Substance)\tquercetin-3-glucoside (Pharmacologic Substance)", + "output": "globulin (Serum Proteins)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate.\nConcepts: Unit of Measure System (Classification)\tADL0122K (Intellectual Product)\tpositive regulation of initiation of acetate catabolic process by acetate (positive regulation of response to acetate)\tBMP signalling pathway involved in renal system segmentation (Molecular Function)\tSputter/Carbon Coaters, Electron Microscopy (In Vitro Diagnostics and Laboratory Equipment)", + "output": "positive regulation of initiation of acetate catabolic process by acetate (positive regulation of response to acetate)" + }, + { + "input": "Definition: Finding described as the presence of discolored lateral incisors.\nConcepts: negative regulation of NK cell cytokine production (Cell Function)\tSH2-Binding Motif (Amino Acid Sequence)\tCDC group Ve-2 (Pseudomonas)\tDiscolored lateral incisors (Tooth structure)\tLIDOCAINE 5% PATCH (lidocaine Topical Product)", + "output": "Discolored lateral incisors (Tooth structure)" + }, + { + "input": "Definition: Antibiotic described as any of a group of broad spectrum naphthacene antibiotics isolated from various species of Streptomyces or produced semisynthetically. In bacteria, tetracycline antibiotics block binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1595\" active clinical trials using this agent.\nConcepts: pyruvate membrane transport (pyruvate transport)\tLPS localization to cell outer membrane (lipid localization)\tUHDR129A (UHDRS 1999 Version Clinical Classification Question)\ttetracycline antibiotic (ANTIBACTERIALS FOR SYSTEMIC USE)\tPharmaceutical Quality/CMC Testing Site Unique Identifier Type Terminology (Unused Subset Concept)", + "output": "tetracycline antibiotic (ANTIBACTERIALS FOR SYSTEMIC USE)" + }, + { + "input": "Definition: Energy Metabolism Pathway described as the chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.\nConcepts: sulfur metabolism (Metabolic Process, Cellular)\tEndocardial Heart Tube (Other Embryologic Structure)\tVS (nuclear viral factory)\tConstipation/Impaction Management (Elimination Management)\tBiologic Risk Code (Risk Code)", + "output": "sulfur metabolism (Metabolic Process, Cellular)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of m7G(5')pppN diphosphatase activity.\nConcepts: Fusibacterium gonidiiformans (Genus Fusobacterium)\tTeratoma of Mediastinum (Teratoma)\tregulation of M(7)G(5')pppN pyrophosphatase activity (Molecular Function)\tTranscription Factor-2, Octamer (Octamer Transcription Factors)\tcycloheximide:proton antiporter activity (Molecular Function)", + "output": "regulation of M(7)G(5')pppN pyrophosphatase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the regulated release of any member of the interleukin-17 family of cytokines from a cell.\nConcepts: Urine concentration defect (Kidney)\tEmbolus Care: Pulmonary (Therapeutic or Preventive Procedure)\tExtrahepatic portal hypertension (Disease or Syndrome)\tIDSR114 (IDS-SR Questionnaire Question)\tCytotoxic T-lymphocyte-associated antigen 8 secretion (cytokine secretion)", + "output": "Cytotoxic T-lymphocyte-associated antigen 8 secretion (cytokine secretion)" + }, + { + "input": "Definition: something described as a subjective score of 5 on a scale that ranges from 0: None to 10: The worst you can think of.\nConcepts: Study Protocol Version Periodic Target Accrual Number (Periodic Target Accrual Number)\tglucosaminyl 3-O-sulfotransferase activity (Molecular Function)\tMCT1 Hyperinsulinism (Disorder of endocrine pancreas)\tprotein deglycase activity (Molecular Function)\tNausea Score 5 (Finding)", + "output": "Nausea Score 5 (Finding)" + }, + { + "input": "Definition: Laboratory or Test Result described as indicates that expression of C2 has not been detected in a sample.\nConcepts: Cold-Stress Responses (Organism Function)\tKeratinized squamous cell of esophagus (Squamous Epithelial Cells)\tlevan hydrolase activity (Molecular Function)\tjaffe-campanacci syndrome (Disorganized development of cartilaginous and fibrous components of the skeleton)\tCD2 Antigen Negative (Expression Negative)", + "output": "CD2 Antigen Negative (Expression Negative)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate.\nConcepts: Care of wet cast (Immobility Management)\tDFNA17 (Cytoskeletal Gene)\tPSA Nadir Plus 2 (Raised prostate specific antigen)\tFacility Closure, Health (Health care facility)\tdeoxy-GTPase activity (Molecular Function)", + "output": "deoxy-GTPase activity (Molecular Function)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with the neurotrophin TRKC receptor.\nConcepts: Toxicology, Non-Drug (Toxicology)\tnegative aerotaxis (negative energy taxis)\tneurotrophin TRKC receptor binding (Molecular Function)\toxygen tension (respiratory oxygen)\t5-hydroxytryptamine antagonists (Serotonin Agents)", + "output": "neurotrophin TRKC receptor binding (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a focal cognitive seizure with dysgraphia / agraphia characterized by retained awareness throughout the seizure.\nConcepts: ECG Test Results (Intellectual Product)\t1,2-5,6-Dianhydrogalactitol (Organic Chemical)\thydrocephalus, agyria, retinal dysplasia with or without encephalocele syndrome (Autosomal recessive hereditary disorder)\tFocal aware cognitive seizure with dysgraphia/agraphia (Disease or Syndrome)\tGAIA Neonatal Respiratory Distress Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)", + "output": "Focal aware cognitive seizure with dysgraphia/agraphia (Disease or Syndrome)" + }, + { + "input": "Definition: something described as any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription.\nConcepts: Ether, Tetraethyleneglycol Lauryl (Non-ionic surfactant)\tnegative regulation of cellular carbohydrate metabolic process by repression of transcription (negative regulation of cellular carbohydrate metabolic process)\tAnatomical space (body cavity, body space, body barrier)\tFlexor hallucis longus in leg (Deep muscle of posterior compartment of leg)\tBALOXAVIR MARBOXIL (Pharmacologic Substance)", + "output": "negative regulation of cellular carbohydrate metabolic process by repression of transcription (negative regulation of cellular carbohydrate metabolic process)" + }, + { + "input": "Definition: pyramidal cell layer of the hippocampus described as a layer of the CA2 field as identified by MRI in the macaque (Macaque Brain by Dubach-2008). It corresponds to the combination of the pyramidal cell layer of the hippocampus and the oriens layer of the hippocampus in the CA2 field.\nConcepts: SH2B Adaptor Protein 2 Gene (Adaptor Signaling Protein Gene)\tmRNA (cytosine-5-)-methyltransferase activity (Genetic Function)\tnew15min inofc NatAm ntak (New client in-office without ICD diagnosis)\ttechnology, manufacturing, and agriculture (Latvian translation of the Medical Subject Headings)\tstratum pyramidale of the CA2 field (layers CApy)", + "output": "stratum pyramidale of the CA2 field (layers CApy)" + }, + { + "input": "Definition: Medical Device described as devices used to produce high-resolution multiformat films directly from image data acquired during diagnostic radiology procedures (e.g., computed tomography, magnetic resonance imaging, ultrasound, digital radiography, digital photospot fluoroscopy), using dry-processing imaging. Typically, dry-processing imagers are used during a procedure that does not require a ribbon (i.e., thermal recording process). The imagers include a thermal head, heat-responsive microcapsules filled with dye precursors, and a developer; when heat is applied, the developer passes through the microcapsule walls and reacts with the dye precursor to form a dye that creates an image on film or paper. Dry-processing imagers allow diagnoses to be made from a hard copy rather than from an electronic image on a monitor screen. They are not intended to digitize film images.\nConcepts: SRCA (Laboratory Procedure)\tImagers, Dry-Processing (Electromechanical Devices)\tCa++-Dependent Secretion Activator 2 (Amino Acid, Peptide, or Protein)\tSRC3 (Gene or Genome)\tEndogenous Factors (Epidemiological Factors)", + "output": "Imagers, Dry-Processing (Electromechanical Devices)" + }, + { + "input": "Definition: Anatomical Abnormality described as partial duplication of the proximal phalanx of fifth toe.\nConcepts: Partial duplication of the innermost bone of the pinky toe (Duplication of the proximal phalanx of the 5th toe)\tInfantile Vomiting, AE (Finding)\tL-phenylalanine aminotransferase activity (Molecular Function)\tMalignant Paranasal Sinus Tumor (Malignant neoplasm of other sites of nasal cavity, middle ear and accessory sinuses)\tFLD (Location)", + "output": "Partial duplication of the innermost bone of the pinky toe (Duplication of the proximal phalanx of the 5th toe)" + }, + { + "input": "Definition: Stage II Hepatocellular Carcinoma AJCC v6 and v7 described as all of the cancer was removed by surgery, except for a small amount of cancer that can be seen only with a microscope, or tumor cells that may have spilled into the abdomen during surgery.\nConcepts: Serositis (inflammatory soft tissue disorders)\tStage II Hepatocellular Cancer (Childhood Hepatocellular Carcinoma)\tpT1c Carcinoma of Ovary v6 (Ovarian Cancer pT1 TNM Finding v6)\tBurkholderia cepacia Complex (Burkholderia)\tDigital Archive (Digital Data Repository)", + "output": "Stage II Hepatocellular Cancer (Childhood Hepatocellular Carcinoma)" + }, + { + "input": "Definition: Document type described as a Category name for the eTMF domain used to classify a set of documents shared between an Institutional Review Board (IRB), Independent Ethics Committee (IEC), or other committee and a sponsor or designee regarding the conduct of a trial. General IRB documents are trial level documents, not site specific documents. Local IRB-IEC are filed under Site Management, IRB-IEC Documents category.\nConcepts: Interleukin 11 Measurement (Cytokine Measurement)\tOral Cachet Dosage Form (Biomedical or Dental Material)\tartificial intelligence (Computer software)\tIRB-IEC Sponsor Communication Category (Document type)\tOleandomycin - chemical (Antibiotic)", + "output": "IRB-IEC Sponsor Communication Category (Document type)" + }, + { + "input": "Definition: Papiliotrema described as any fungal organism that can be assigned to the species Cryptococcus laurentii.\nConcepts: Extracellular Signal-Regulated Kinase, p97 (Amino Acid, Peptide, or Protein)\tCryptococcus laurentii (Papiliotrema)\tImmunoradiotherapies (Radionuclide therapy)\thh signaling pathway involved in spinal cord motor neuron cell fate specification (Molecular Function)\tRXR binding (retinoic acid receptor binding)", + "output": "Cryptococcus laurentii (Papiliotrema)" + }, + { + "input": "Definition: Miscellaneous Molecular Biology Terms described as general term for a piece of DNA or RNA corresponding to a gene or sequence of interest, that has been labelled either radioactively or with some other detectable molecule, such as biotin, digoxygenin or fluorescein. As stretches of DNA or RNA with complementary sequences will hybridize, a probe will label viral plaques, bacterial colonies or bands on a gel that contain the gene of interest.\nConcepts: secondary metabolic process (Metabolism)\tLights, Illumination, Stand-Alone (Lights, Illumination)\tlipid sensor activity (Molecular Function)\tLYMAT (Lymphocyte Count measurement)\tprobe gene fragment (Gene or Genome)", + "output": "probe gene fragment (Gene or Genome)" + }, + { + "input": "Definition: Hematologic Tests described as a measurement of the Auer rods (elongated needle structures that are found in the cytoplasm of leukemic blasts and are formed by clumps of azurophilic granular material) in a biological specimen.\nConcepts: AUERRODS (Laboratory Procedure)\tIrrigators, Wound (Medical Device)\tinfratonic therp ea.20min (Sound - physical agent)\tglucosylglycerol synthesis (Molecular Function)\tUnclassified Cast Measurement (Laboratory Procedure)", + "output": "AUERRODS (Laboratory Procedure)" + }, + { + "input": "Definition: Primary malignant neoplasm described as a chondrosarcoma of adolescence to old age of the proximal EPIPHYSES of long bones. It has variably clear cytoplasm of the mostly neoplastic CHONDROCYTES with little intervening matrix.\nConcepts: IDSC1-Panic/Phobic Symptoms (IDS-C Clinical Classification Question)\thyperemesis gravidarum (Other complications of pregnancy)\tRelapsed Malignant Mesothelioma of the Pleura (Mesothelioma malignant recurrent)\tClear Cell Chondrosarcoma (Chondrosarcoma - category)\tSystemic arterial tree (Arterial tree organ)", + "output": "Clear Cell Chondrosarcoma (Chondrosarcoma - category)" + }, + { + "input": "Definition: Eyelid Carcinoma Clinical Regional Lymph Nodes TNM Finding v8 described as eyelid carcinoma with metastasis in a single ipsilateral regional lymph node, measuring more than 3 cm in greatest dimension, or in bilateral or contralateral lymph nodes.\nConcepts: CSS0607 (C-SSRS Children's Baseline Questionnaire Question)\tTentorial sinus (Straight sinus and its tributaries)\tEyelid Carcinoma cN2 TNM Finding v8 (Finding)\tFollicular (Body Part, Organ, or Organ Component)\tXIAP Associated Factor 1 wt Allele (XAF1 gene)", + "output": "Eyelid Carcinoma cN2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in antigen presentation.\nConcepts: tapasin (Gene or Genome)\tChlamydia trachomatis (Bacterium)\tCock-walk gait (Dystonic gait)\tSGRQC1 (Clinical or Research Assessment Questionnaire)\tStandard Gibbs Free Energy Change (Physical Phenomenon or Property)", + "output": "tapasin (Gene or Genome)" + }, + { + "input": "Definition: Oncologic complications and emergencies described as a condition in which cancer causes an abnormal amount of fluid to collect between the thin layers of tissue (pleura) lining the outside of the lung and the wall of the chest cavity. Lung cancer, breast cancer, lymphoma, and leukemia cause most malignant pleural effusions.\nConcepts: Object Title (Name)\tmucin 4, tracheobronchial protein, human (Binding Proteins)\tmalignant effusion (Pleural effusion in conditions classified elsewhere)\tVOXDIMZ (Voxel Size)\tSuccinylcholine Chloride (S [Preparations])", + "output": "malignant effusion (Pleural effusion in conditions classified elsewhere)" + }, + { + "input": "Definition: Occupational Activity described as monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the air; includes periodic or continuous surveillance or testing to determine the level of compliance with statutory requirements and/or pollutant levels in the air.\nConcepts: regulation of voltage-sensitive sodium channel (regulation of sodium ion transmembrane transporter activity)\tFocal aware autonomic seizure with erection (Disease or Syndrome)\tprotein-bound paclitaxel (Organic Chemical)\tAdrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage (Sympathetic paraganglioma)\tair sampling/monitoring (evaluation/testing)", + "output": "air sampling/monitoring (evaluation/testing)" + }, + { + "input": "Definition: Expression Negative described as an indication that CD38 expression has not been detected in a sample.\nConcepts: MALAR RASH (Head finding)\tSGRQ0115 (Intellectual Product)\tADP-Ribosyl Cyclase 1 Negative (Expression Negative)\tTannicum acidum / tannic acid (Pharmacologic Substance)\tCode Translation (Machine Activity)", + "output": "ADP-Ribosyl Cyclase 1 Negative (Expression Negative)" + }, + { + "input": "Definition: Intellectual Product described as a domain utilized for the submission of subject characteristics records related to persons associated with the study subject.\nConcepts: Unplanned (General Qualifier)\tAssociated Persons Subject Characteristics (Associated Persons Domain)\tDrug Metabolism Induction (Molecular Function)\tAsystole, CTCAE 5.0 (Cardiac Disorders, CTCAE)\tMass Spectrometer Sample Ionizers, Real Time (In Vitro Diagnostics and Laboratory Equipment)", + "output": "Associated Persons Subject Characteristics (Associated Persons Domain)" + }, + { + "input": "Definition: regulation of integrin biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins.\nConcepts: Unknown Primary Tumor Clinical Cervical Lymph Nodes TNM Finding v8 (Head and Neck Cancer Clinical TNM Finding v8)\tregulation of beta 2 integrin formation (regulation of integrin biosynthetic process)\tVasogenic Edema (Finding)\tCYR61 Protein (Amino Acid, Peptide, or Protein)\tCoated aorta (Disease or Syndrome)", + "output": "regulation of beta 2 integrin formation (regulation of integrin biosynthetic process)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as complete removal of the fallopian tube(s).\nConcepts: Complete Salpingectomy (Salpingectomy)\tNeoplastic Plasma Cells 10-59 Percent of Bone Marrow Nucleated Cells (Finding)\tpakd rthrocyts elemntl anal. (nutritional analysis)\tPsychological testing each 15 minutes (Health Care Activity)\tAtomizer, device (Electromechanical Devices)", + "output": "Complete Salpingectomy (Salpingectomy)" + }, + { + "input": "Definition: WNT Family Gene described as this gene plays a role in signal transduction and intercellular communication. It is involved in the growth of progenitor cells during embryogenesis.\nConcepts: Orthoses, Lower Limb, Foot, Accommodative (Medical Device)\tWNT2B Gene (Gene or Genome)\tEncorafenib-containing product (Antineoplastic Enzyme Inhibitor)\tATP:D-glucose 6-phosphotransferase activity (Molecular Function)\tAurora B Serine/Threonine Kinase Inhibitor TAK-901 (Aurora Kinase Inhibitor)", + "output": "WNT2B Gene (Gene or Genome)" + }, + { + "input": "Definition: Neoplastic Process described as a squamous cell carcinoma arising in a skin site exposed to solar radiation.\nConcepts: Solid dose form (Biomedical or Dental Material)\tSolar Radiation-Related Skin Squamous Cell Carcinoma (Solar Radiation-Related Malignant Neoplasm)\tGirodazole (Pharmacologic Substance)\tTomographic Laser Scanners (Medical Device)\tUnable to do (Finding)", + "output": "Solar Radiation-Related Skin Squamous Cell Carcinoma (Solar Radiation-Related Malignant Neoplasm)" + }, + { + "input": "Definition: something described as immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.\nConcepts: tetraurelias, Paramecium (Eukaryote)\tdetection of other organism (detection of external biotic stimulus)\tCounterimmunoelectrophoresis (HCPCS Level I Preferred Terms, Obsolete)\tExtent Have Felt Ill (Clinical or Research Assessment Question)\tAble to Think Clearly and Solve Day-to-day Problems (Finding)", + "output": "Counterimmunoelectrophoresis (HCPCS Level I Preferred Terms, Obsolete)" + }, + { + "input": "Definition: MT-RNR2 gene described as human MT-RNR2 wild-type allele is located within the circular mitochondrial (MT) chromosome and is approximately 2 kb in length. This allele, which encodes both 16S mitochondrial ribosomal RNA and humanin protein, is involved in mitochondrial protein translation and the negative regulation of apoptosis.\nConcepts: ATP-dependent microtubule motor activity (Molecular Function)\tpositive regulation of glycogen synthesis (Cell Function)\tMitochondrially Encoded 16S RNA wt Allele (Gene or Genome)\tbaclofen/amitriptyline/ketamine gel (Pharmacologic Substance)\tSource Age (Finding)", + "output": "Mitochondrially Encoded 16S RNA wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Drug level decreased described as decreased time following drug administration at which the peak drug blood concentration occurs.\nConcepts: Arthromyodysplasia, Congenital (MULTISYSTEM DISORDER)\tscaffold attachment factor B (Gene or Genome)\tDECREASED DRUG TMAX (Finding)\tType II Collagen C-Telopeptides (Laboratory Procedure)\tparallel actin filament bundle assembly (actin filament bundle assembly)", + "output": "DECREASED DRUG TMAX (Finding)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an erythrocytic glucose-6-phosphate dehydrogenase assay is a device used to measure the activity of the enzyme glucose-6-phosphate dehydrogenase or of glucose-6-phosphate dehydrogenase isoenzymes. The results of this assay are used in the diagnosis and treatment of nonspherocytic congenital hemolytic anemia or drug-induced hemolytic anemia associated with a glucose-6-phosphate dehydrogenase deficiency. This generic device includes assays based on fluorescence, electrophoresis, methemoglobin reduction, catalase inhibition, and ultraviolet kinetics.\nConcepts: regulation of ER stress-induced neuron intrinsic apoptotic signaling pathway (regulation of neuron apoptotic process)\tFcGR (FCGR2A gene)\tIgG4 Measurement (Laboratory Procedure)\tNormal periodontal tissue with attachment loss (Finding)\tISOENZYMES, ELECTROPHORETIC, GLUCOSE-6-PHOSPHATE DEHYDROGENASE (Indicator, Reagent, or Diagnostic Aid)", + "output": "ISOENZYMES, ELECTROPHORETIC, GLUCOSE-6-PHOSPHATE DEHYDROGENASE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Organic Chemical described as sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.\nConcepts: Sulfonium Compounds (Onium Compounds)\t9q31.1q31.3 microdeletion syndrome (Disease or Syndrome)\tSurgical Procedures on the Cardiovascular System (Cardiovascular Surgical Procedures)\tSubglottic Carcinoma pT4 TNM Finding v8 (Subglottic Cancer Pathologic Primary Tumor TNM Finding v8)\tTeratoma with malignant transformation (Malignant teratoma - category)", + "output": "Sulfonium Compounds (Onium Compounds)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.\nConcepts: I-Kappa-B (Amino Acid, Peptide, or Protein)\tdiacylglycerol metabolic process (acylglycerol metabolic process)\tNPI1-Take Liberties or Touch Others (NPI Questionnaire Question)\tinterleukin-23 production (Organism Function)\tSerrate Proteins (Amino Acid, Peptide, or Protein)", + "output": "diacylglycerol metabolic process (acylglycerol metabolic process)" + }, + { + "input": "Definition: Cell Cycle Proteins described as tumor suppressor gene products; cell cycle regulatory proteins; deregulation is theorized to lead to tumorigenesis.\nConcepts: Pulmonary Reactance (Pulmonary function tests)\tdisorders eyelid (Disease or Syndrome)\tSPINOCEREBELLAR ATAXIA, 16q22-LINKED (Ataxia, Spinocerebellar)\ttumour suppressor protein (Protein, Organized by Function)\tErythrophagocytosis (White blood cell abnormal findings NEC)", + "output": "tumour suppressor protein (Protein, Organized by Function)" + }, + { + "input": "Definition: Chest and abdomen described as the anterior side of the thorax from the neck to the abdomen. The shape of the chest is often regarded as potential insight into a disease process, as in the case of barrel chest and respiratory dysfunction.\nConcepts: high risk behavior/lifestyle (Obsessive compulsive behavior)\tPhage Therapy (Therapeutic or Preventive Procedure)\tContract Research Organization (Research Organization)\tFine Granular Cast Measurement (Laboratory Procedure)\tarea thoracic (Trunk structure)", + "output": "area thoracic (Trunk structure)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version - Have you made a suicide attempt? Have you done anything to harm yourself? Have you done anything dangerous where you could have died? (Lifetime).\nConcepts: CSS1112A (C-SSRS Lifetime/Recent Version Questionnaire Question)\tCHRONIC IDIOPATHIC JAUNDICE (Disorder of bilirubin metabolism)\tN-Acetyl Glucosamide to Creatinine Ratio Measurement (Laboratory Procedure)\tpigment cell development (Cell Function)\tOphthalmic Image Digitization System Software (Software, Image Digitization System)", + "output": "CSS1112A (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: Neck Lymph Node Boundary Levels and Sublevels described as the following anatomical structures define the neck lymph node boundary for level VII: Superior: suprasternal notch; inferior: innominate artery; anterior (medial): sternum; posterior (lateral): trachea, esophagus, and prevertebral fascia.\nConcepts: Traditional Indigenous System (Alternative Medical System)\tGrade 2 Facial Pain, CTCAE (Finding)\tCD (Clinical Attribute)\tCervicothoracic spine orthosis (Orthoses, Spine)\tNeck Lymph Node Boundary Level VII (Finding)", + "output": "Neck Lymph Node Boundary Level VII (Finding)" + }, + { + "input": "Definition: something described as human EPS8L3 wild-type allele is located in the vicinity of 1p13.3 and is approximately 14 kb in length. This allele, which encodes EPS8-like 3 protein, is involved in erythroid differentiation and proliferation. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been identified in cases of chronic myeloproliferative disorder.\nConcepts: FOSQUIDONE (Organic Chemical)\tMigration or Expulsion of Device (Unintended Movement Medical Device Problem)\tCarbonates, Hydrogen (Electrolytes)\tEPS8-Like 3 Gene (EPS8L3 gene)\tRight Coronary Artery Ostium (Coronary artery)", + "output": "EPS8-Like 3 Gene (EPS8L3 gene)" + }, + { + "input": "Definition: Neoplasm of skeletal system described as a benign, well-circumscribed, bone-forming neoplasm predominantly composed of lamellar bone. It usually arises from the calvarial, facial, or jaw bones. It is usually asymptomatic but it may cause local swelling or obstruction of the paranasal sinuses. Asymptomatic cases have an indolent clinical course.\nConcepts: benign osteoma of bone (Neoplasms, Bone Tissue)\tAntigen of Bacillus Calmette-Guerin (Antigens, Bacterial)\tGrade 1 Skin Hyperpigmentation, CTCAE (Skin Hyperpigmentation, CTCAE 5)\tBuccal pouch (Cheek structure)\tPhobias NOS (other psychiatric disorders)", + "output": "benign osteoma of bone (Neoplasms, Bone Tissue)" + }, + { + "input": "Definition: Medical Device described as breast implants that are either prefilled or filled during surgery with saline solution. These implants typically consist of a single-lumen outer shell (e.g., silicone elastomer), saline solution as filler, and a patch to seal the shell once filled. The implants may be either prefilled or filled during surgery through a valve with a fixed volume of saline; some implants that are filled during surgery may allow adjustment of the saline content after implantation. Saline breast implants are intended for breast reconstruction and/or augmentation.\nConcepts: BREAST IMPLANT SALINE (Device associated with saline solutions)\t4K (Laboratory Procedure)\tAbnormal metabolism (Finding)\t(2beta,3beta,4beta,5alpha,12beta,19alpha)-4-(Acetyloxy)-6,7-didehydro-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid (Multidrug Resistance Modulator)\tanaerobic ribonucleoside-triphosphate reductase complex (Cell Component)", + "output": "BREAST IMPLANT SALINE (Device associated with saline solutions)" + }, + { + "input": "Definition: Hospital Departments described as hospital department responsible for the administration and management of nuclear medicine services.\nConcepts: Diethyldithiocarbamate (D [Preparations])\tBacteroides faecis (Bacterium)\tVSL3 (Pharmacologic Substance)\tHospital Nuclear Medicine Department (Hospital Departments)\tForename (Person Name)", + "output": "Hospital Nuclear Medicine Department (Hospital Departments)" + }, + { + "input": "Definition: something described as an immunohistochemical technique used to detect the presence of vitamin D3 receptor in a tissue sample.\nConcepts: 15q11.2 (Cell Component)\tcell wall beta-1,3 glucan metabolic process (Molecular Function)\tVDR Staining Method (Immunohistochemistry)\tSocial skills behavior modification (Behavior Therapy)\tCatheters, Spinal, Epidural, Anesthetic (Epidural catheter)", + "output": "VDR Staining Method (Immunohistochemistry)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: UDP-alpha-D-glucose + 7,8-dihydroxycoumarin <=> UDP + 4-O- beta -D-glucosyl-daphnetin + H+.\nConcepts: daphnetin 4-O-beta-glucosyltransferase activity (hexosyltransferase activity)\tplasma membrane proton-transporting ATP synthase, stator stalk (plasma membrane protein complex)\tLaboratory Test Reference Range Upper Limit Original Unit (High Test Reference Range)\tClinical Outcome Assessment Construct Validation (Quantitative Concept)\tareca catechu/betel nut (Homeopathic remedies letter A)", + "output": "daphnetin 4-O-beta-glucosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: Clinical Trials described as trials that consider an individual patient as the sole unit of observation in a study investigating the efficacy or side-effects of different interventions to determine the optimal intervention for an individual patient using objective data-driven criteria.\nConcepts: Single-Case Study (Research Activity)\tCharge, Static (Natural Phenomenon or Process)\tObturation obstruction of intestine (Intestinal Obstruction)\tMET Tyrosine Kinase Inhibitor EMD 1204831 (Antineoplastic Enzyme Inhibitor)\tPluralibacter gergoviae (Enterobacter)", + "output": "Single-Case Study (Research Activity)" + }, + { + "input": "Definition: protein-containing complex described as a conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.\nConcepts: Cervical Serous Adenocarcinoma (Serous Cystadenocarcinoma)\tSacral Flexion (Finding of movement of sacrum)\tmelanosome assembly (melanosome organization)\tchromatin assembly factor 1 complex (protein-containing complex)\tconnexin complex (Cell Component)", + "output": "chromatin assembly factor 1 complex (protein-containing complex)" + }, + { + "input": "Definition: something described as indicates the person or authoritative body who brought the item into existence.\nConcepts: METMA-B (Antineoplastic Antibody)\tApparent mineralocorticoid excess (Endocrine disorders congenital NEC)\tdownregulation of chemokine (C-C motif) ligand 20 production (Organism Function)\tblowflies (Diptera)\tCreated By (General Qualifier)", + "output": "Created By (General Qualifier)" + }, + { + "input": "Definition: Mucosal Melanoma described as a primary malignant neoplasm of the vagina composed of malignant melanocytes.\nConcepts: 5-methylthioribose kinase activity (Molecular Function)\tCT with Contrast of Inguinal Region (Diagnostic Procedure)\tVaginal Melanoma (Neoplastic Process)\tnegative regulation of DNA damage checkpoint (negative regulation of response to DNA damage stimulus)\tResidue on Pyriform Sinuses Following Swallowing (Location of Pharyngeal Residue Following Swallowing)", + "output": "Vaginal Melanoma (Neoplastic Process)" + }, + { + "input": "Definition: Cell described as a group of cells identified on FLOW CYTOMETRY profiles as distinct from the main group of cells by their ability to extrude the fluorescent dye Hoechst 33342, often a characteristic property of less differentiated progenitor and STEM CELLS.\nConcepts: Anal Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Finding)\tAsthma, NOS (Lung)\tCarts, Central Supply, Intravenous Solution Bag/Container (Carts, Central Supply)\tSide Population Cells (Stem cells)\tNot applicable (NoInformation)", + "output": "Side Population Cells (Stem cells)" + }, + { + "input": "Definition: Other extrapyramidal diseases and abnormal movement disorders described as neuronal degeneration in the cerebellum, pontine nuclei, and inferior olivary nucleus.\nConcepts: PF 06651600 (Organic Chemical)\tGOSE1-Similar Problems Before Injury (GOSE Questionnaire Question)\tcomputed tomography perfusion (X-Ray Computed Tomography)\tVeterinary School (Manufactured Object)\tD\u00e9jerine-Thomas atrophy (Non-Neoplastic Brain Disorder)", + "output": "D\u00e9jerine-Thomas atrophy (Non-Neoplastic Brain Disorder)" + }, + { + "input": "Definition: Manufactured Object described as controllers designed to regulate the performance of a chromatography system from a single point. These controllers may control each of the modules (e.g., columns, detectors) of a chromatography system from a centralized control point; controllers typically can identify each component, control the transfer of samples between modules, and display the status of the system using dedicated software. Chromatography system controllers are intended to facilitate performance of automated chromatography tests with fewer errors in the procedure; they can interact with a laboratory information system by receiving and/or sending information.\nConcepts: Controllers, Chromatography System (Manufactured Object)\tRegistrar (Professional or Occupational Group)\tSaxitonin (Marine Toxins)\tpositive regulation of supramolecular fiber organization (positive regulation of cellular component organization)\tNeuroimaging, Functional (Research Activity)", + "output": "Controllers, Chromatography System (Manufactured Object)" + }, + { + "input": "Definition: Intellectual Product described as a question about how much an individual's symptoms interfere or interfered with their mood.\nConcepts: carbon catabolite activation of transcription (carbon catabolite regulation of transcription)\tProstate malignant tumors (Classification)\tMeninges, NOS (Membrane of the Brain or Spinal Cord)\tSymptoms Interfered with Mood (Intellectual Product)\tD-xylose ketoisomerase activity (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)", + "output": "Symptoms Interfered with Mood (Intellectual Product)" + }, + { + "input": "Definition: Finding described as the status of the device is unknown.\nConcepts: positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (Cell Function)\tDevice Status Unknown (Finding)\tLOC285194 (Gene or Genome)\tIVD Panels, Human Genetics, Neurodevelopmental Disorder, Nerve, Hirschsprung Disease, Mutation (Medical Device)\tsplicing factor proline and glutamine rich (Gene or Genome)", + "output": "Device Status Unknown (Finding)" + }, + { + "input": "Definition: Thyroid & Parathyroid Glands: Excision described as surgery involving the complete excision of the thyroid gland.\nConcepts: MAGI-2 Gene Mutation (Gene Mutant)\tprotein amino acid phosphate-linked glycosylation via serine (Molecular Function)\tLysine Methyltransferase 2A Gene Mutation (Cell or Molecular Dysfunction)\tREMOVAL OF THYROID (Thyroid & Parathyroid Glands: Excision)\tIncreased level of oxalate in urine (Urinary abnormalities)", + "output": "REMOVAL OF THYROID (Thyroid & Parathyroid Glands: Excision)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the formation of basement membrane collagen structures.\nConcepts: catabolism by organism of macromolecule in other organism involved in symbiotic interaction (Molecular Function)\tSelf Criticism (criticism)\tcollagen type IV alpha 2 (Collagen Gene)\tMitochondrial complex I deficiency due to deficiency of acyl-coenzyme A dehydrogenase 9 (Disease or Syndrome)\tDRRI1D01 (DRRI-2 Questionnaire Question)", + "output": "collagen type IV alpha 2 (Collagen Gene)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Initial/first attempt potential lethality.\nConcepts: proline-rich region binding (Molecular Function)\tCSS05-First Attempt Potential (Intellectual Product)\tdown-regulation of microglia differentiation (negative regulation of glial cell differentiation)\tPractice, Public Health (public health medicine)\tCarbenicillin Disodium (Extended Spectrum Penicillin Antibiotic)", + "output": "CSS05-First Attempt Potential (Intellectual Product)" + }, + { + "input": "Definition: Trunk structure described as that portion of the body that lies between the THORAX and the PELVIS.\nConcepts: Ameliorated by pregnancy (Finding)\tabdominal (Whole body)\tGBR (Europe)\tIntraspinal Injection (Spinal Canal & Spinal Cord Structures: Application, Insertion, Removal)\tIL-1 secretion (Cell Function)", + "output": "abdominal (Whole body)" + }, + { + "input": "Definition: Organic Chemical described as polyunsaturated fatty acid with 18 carbons and 4 double bonds at the 3rd, 6th, 9th, and 12th carbons from the methyl end.\nConcepts: CHDH gene (Oxidoreductase Gene)\tArginine-transfer ribonucleic acid ligase (Enzyme)\tFatty Acid 18:4 n-3 (parinaric acid)\tCocculus/Nux vomica/Tabacum/Petroleum Extract (Organic Chemical)\tXBP1 Gene (Transcription factor genes)", + "output": "Fatty Acid 18:4 n-3 (parinaric acid)" + }, + { + "input": "Definition: Amino Acids described as found in large amounts in the plasma and urine of patients with malignant melanoma. It is therefore used in the diagnosis of melanoma and for the detection of postoperative metastases. Cysteinyldopa is believed to be formed by the rapid enzymatic hydrolysis of 5-S-glutathionedopa found in melanin-producing cells.\nConcepts: L-Tyrosine, 3-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (R)- (Dopa)\tVascular constriction, function (Hemodynamics)\tendothelial cell fate determination (cell fate determination)\tskin wrist (Skin structure of upper limb)\tAbnormality of the lower urinary tract (Abnormality of the urinary system)", + "output": "L-Tyrosine, 3-((2-amino-2-carboxyethyl)thio)-5-hydroxy-, (R)- (Dopa)" + }, + { + "input": "Definition: Urinary Calculi described as low-density crystals or stones in any part of the URINARY TRACT. Their chemical compositions often include CALCIUM OXALATE, magnesium ammonium phosphate (struvite), CYSTINE, or URIC ACID.\nConcepts: NIDCR (Component of the National Institutes of Health)\tStone, Urinary (Genitourinary tract problem)\tHock (Body Part, Organ, or Organ Component)\t16: 64958064-64996190 (Spatial Concept)\tFPA 150 (Pharmacologic Substance)", + "output": "Stone, Urinary (Genitourinary tract problem)" + }, + { + "input": "Definition: Disorder of eye described as pathologic changes of the eye due to a severe complication of diabetes mellitus.\nConcepts: Units of Presentation (EDQM Health Care Terminology)\tnursing audits (Clinical Audit)\tbasophil cell differentiation (Cell Function)\tdiabetic ophthalmopathy (Diabetes Mellitus)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SMN2 (Medical Device)", + "output": "diabetic ophthalmopathy (Diabetes Mellitus)" + }, + { + "input": "Definition: Molecular Function described as the cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed.\nConcepts: Analyzers, Laboratory, Microbiology, Urine Bacteriuria (Medical Device)\tCyclin Regulation of Cell Cycle Pathway (Molecular Function)\tCPHD4 (Gene or Genome)\tEthylestrenol product (Adrenal Cortex Hormones)\tFAC061-I Have Tremors (FACT-BMT Version 4 Questionnaire Question)", + "output": "Cyclin Regulation of Cell Cycle Pathway (Molecular Function)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in).\nConcepts: Metastatic Appendix Carcinoma (Neoplastic Process)\tglutamate:sodium symporter activity (amino acid:sodium symporter activity)\tMethicillin resistance (Penicillin Resistance)\tDECOQUINATE (Organic Chemical)\tHealth risk factor education (Patient counseling education)", + "output": "glutamate:sodium symporter activity (amino acid:sodium symporter activity)" + }, + { + "input": "Definition: Organization and Administration described as health care professional business directed towards treatment and care of patients.\nConcepts: IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Campylobacter Species (Medical Device)\tlarval foraging behavior (Individual Behavior)\tdownregulation of ubiquitin transferase activity (negative regulation of protein ubiquitination)\tFamily Aeromonadaceae (Bacterium)\tpractice professional (Occupational Activity)", + "output": "practice professional (Occupational Activity)" + }, + { + "input": "Definition: Growth and Development function described as milestones of physical, cognitive, and psychosocial progression from 6 years through 11 years of age\nConcepts: Estonia (Europe, Eastern)\tHemoglobin Theta 1 wt Allele (HBQ1 gene)\tChild development: middle childhood (Finding)\tMIC (Native North American language)\tL-methionine formation from S-adenosylmethionine (Molecular Function)", + "output": "Child development: middle childhood (Finding)" + }, + { + "input": "Definition: Anatomical Abnormality described as absence of the anterior chamber of the eye owing to a developmental defect. []\nConcepts: Absent anterior chamber of eye (Anatomical Abnormality)\tStratum basalis of endometrium (Layer of endometrium)\tDental Attachments, Semiprecision, Partial Denture, Implant (Medical Device)\tacidocalcisome lumen (intracellular organelle lumen)\tmicroRNA 509 (Gene or Genome)", + "output": "Absent anterior chamber of eye (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as analytic techniques for modeling decision making in light of possible consequences or outcomes.\nConcepts: guideline practice (Intellectual Product)\tDecision Theory (Intellectual Product)\tIdelalisib Regimen (Regimen Used to Treat Non-Hodgkin Lymphoma)\tMultilayered ER Tab (Biomedical or Dental Material)\tRFSTDTC (Observation Start Date Time)", + "output": "Decision Theory (Intellectual Product)" + }, + { + "input": "Definition: Malignant neoplasm of lung described as a group of at least three distinct histological types of lung cancer, including non-small cell squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Non-small cell lung carcinomas have a poor response to conventional chemotherapy.\nConcepts: Non Small Cell Lung Cancer NOS (Carcinoma of lung)\tDefined Criterion Group Composition Relationship Join Code (Join Code)\tabnormalities joint (Abnormality of skeletal morphology)\tRNA polymerase I core element sequence-specific DNA binding (Genetic Function)\tmale gametophyte formation (Cell Function)", + "output": "Non Small Cell Lung Cancer NOS (Carcinoma of lung)" + }, + { + "input": "Definition: Structure of deltoid muscle described as the muscle that creates the rounded contour of the shoulder which originates from the lateral third of the clavicle, the superior surface of the acromion process, and the posterior border of the spine of the scapula and inserts on the lateral side of the shaft of the humerus. The deltoid muscle is innervated by the brachial plexus arising from the fifth and sixth cervical nerves and controls abduction, extension, flexion, and rotation of the arm. This is the deltoid on the right side of the body.\nConcepts: Kromfohrlander (Mammal)\tTFIIA Subunit Gene (Gene or Genome)\tRight deltoid (Structure of deltoid muscle)\tTRAM-dependent toll-like receptor signaling pathway (Molecular Function)\t8A1 FAMILY EQUIDAE - EQUIDS (Mammal)", + "output": "Right deltoid (Structure of deltoid muscle)" + }, + { + "input": "Definition: Fluid Balance described as swelling due to an excessive accumulation of fluid in the upper or lower extremities.\nConcepts: public assistance (Financing, Government)\tpurine nucleotide formation (purine nucleotide metabolic process)\textremity edema (Total fluid volume increased)\tmtDNA breakdown (mitochondrial DNA metabolic process)\tnmol/l/(ug/m2/d) (Measurement Unit Description)", + "output": "extremity edema (Total fluid volume increased)" + }, + { + "input": "Definition: something described as a finding about one or more characteristics of sarcoma of the orbit, following the rules of the TNM AJCC v7 classification system. No stage grouping is presently recommended for sarcoma of the orbit.\nConcepts: Dissociative disorder or reaction, unspecified (Dissociative, conversion and factitious disorders)\tup-regulation of AMPA receptor clustering (regulation of AMPA glutamate receptor clustering)\tAir Cleaners, Particulate/Gas/Vapor, Germicidal (Air Cleaners, Particulate/Gas/Vapor)\tSarcoma of the Orbit TNM Finding v7 (Ophthalmic Sites Cancer TNM Finding v7)\tMutagenic Process (Cell or Molecular Dysfunction)", + "output": "Sarcoma of the Orbit TNM Finding v7 (Ophthalmic Sites Cancer TNM Finding v7)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of study outcome measure. EXAMPLE(S): n/a, safety, efficacy, bio-equivalence, bio-availability, pharmacokinetics, pharmacodynamics\nConcepts: Agents, Anti-Diuretic (Pharmacologic Substance)\tThe atmosphere in our home is calm (Intellectual Product)\tIC512AB (Laboratory Procedure)\tStudyOutcomeMeasure.typeCode (Intellectual Product)\tRecombinant 7 (Murine leukemia virus)", + "output": "StudyOutcomeMeasure.typeCode (Intellectual Product)" + }, + { + "input": "Definition: General Qualifier described as the state of reverse blood flow through a valve or orifice\nConcepts: nicotinate-nucleotide adenylyltransferase activity (Molecular Function)\tVoltage-Dependent Anion Channel 1 (Amino Acid, Peptide, or Protein)\tRetrograde direction (General Qualifier)\trecombinant hsp110-gp100 chaperone complex vaccine (Pharmacologic Substance)\tundef.saliva anal.narr req'd (Saliva analysis)", + "output": "Retrograde direction (General Qualifier)" + }, + { + "input": "Definition: something described as catalysis of the hydroxylation of an ecdysteroid at carbon position 25. Ecdysteroids are a group of polyhydroxylated ketosteroids which initiate post-embryonic development, particularly metamorphosis, in insects and other arthropods.\nConcepts: Granule for Syrup Dosage Form (Granules dose form)\tecdysteroid 25-hydroxylase activity (Molecular Function)\tt-circle formation (Genetic Function)\tProducts, Vegetable (Food)\tSPERMATID RETENTION (Finding)", + "output": "ecdysteroid 25-hydroxylase activity (Molecular Function)" + }, + { + "input": "Definition: Multiple malformation syndrome with facial-limb defects as major feature described as a rare genetic syndrome characterized by agenesis of the corpus callosum, polydactyly, mental and motor retardation.\nConcepts: Dictation Systems, Digital, Speech Recognition/Transcription (Digital dictation system)\tAcrocallosal Syndrome (Multiple malformation syndrome with facial-limb defects as major feature)\tPhosphodiesterase (Enzyme)\tMHC protein complex location (plasma membrane protein complex)\tOvarian Cancer by FIGO Stage (Neoplastic Process)", + "output": "Acrocallosal Syndrome (Multiple malformation syndrome with facial-limb defects as major feature)" + }, + { + "input": "Definition: ubiquitin-protein ligase described as TNF receptor-associated factor 6 (522 aa, ~60 kDa) is encoded by the human TRAF6 gene. This protein is involved in polyubiquitination of protein substrates.\nConcepts: Interleukin 1 Signal Transducer (ubiquitin-protein ligase)\tnegative regulation of blood vessel endothelial cell differentiation (Cell Function)\tAngiotensin 1 (Polypeptide Hormones)\t5-Hydroxytetracycline (Medicinal product categorized by structure)\tFMC63-28Z CAR-transduced Allogeneic T-lymphocytes (Cell)", + "output": "Interleukin 1 Signal Transducer (ubiquitin-protein ligase)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of rituximab, gemcitabine and oxaliplatin used in the treatment of diffuse large B-cell lymphoma (DLBCL).\nConcepts: TOURNIQUET, PNEUMATIC (Medical Device)\tEnlarged epiphysis of the proximal phalanx of the thumb (Abnormality of the epiphysis of the proximal phalanx of the thumb)\tRituximab-Gemcitabine-Oxaliplatin (Regimen Used to Treat Non-Hodgkin Lymphoma)\tNephrosis (Kidney)\tpositive regulation of granulocyte differentiation (regulation of granulocyte differentiation)", + "output": "Rituximab-Gemcitabine-Oxaliplatin (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Chromosome 2 Physical Location described as physical location of CREB1_Gene\nConcepts: Genetic Reference Sequence Identifier (Intellectual Product)\tAmbulance Diversions (Health Care Activity)\tt(1;19)(q10;p10) (Chromosomal translocation)\tboss receptor activity (transmembrane receptor protein tyrosine kinase activity)\t2: 208220192-208289079 (Spatial Concept)", + "output": "2: 208220192-208289079 (Spatial Concept)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Already Enrolled Subjects (C-SSRS Already Enrolled Subjects ) Total number of interrupted. (Since Study Start).\nConcepts: Bullet-shaped bones of the 4th toe (Bullet-shaped toe phalanx)\tacute leukemia not otherwise specified (Acute leukemia)\tvoltage-gated potassium channel activity involved in SAN cell action potential depolarization (Molecular Function)\tC-SSRS Already Enrolled Subjects - Number of Interrupted Suicide Attempts (Intellectual Product)\tDKFZp779K1053 (HDAC9 gene)", + "output": "C-SSRS Already Enrolled Subjects - Number of Interrupted Suicide Attempts (Intellectual Product)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as a rare neurologic disease characterized by global developmental delay, intellectual disability, multiple ischemic lesions on brain MRI, behavioral abnormalities, dystonia, choreic movements and pyramidal syndrome, facial dysmorphism (hypertelorism, arched palate, macroglossia), retinitis pigmentosa, scoliosis, seizures.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tAutosomal recessive leukoencephalopathy, ischaemic stroke, retinitis pigmentosa syndrome (Congenital vascular disorder)\tregulation of intestinal cholesterol absorption (regulation of cholesterol transport)\tBernard Syndrome (Oncologic complications and emergencies)\tIBP3 (Gene or Genome)", + "output": "Autosomal recessive leukoencephalopathy, ischaemic stroke, retinitis pigmentosa syndrome (Congenital vascular disorder)" + }, + { + "input": "Definition: Computer-enhanced radiology described as taking and analyzing an X-ray image of a client/patient's nonspinal, skeletal body part or region to assess his or her condition in motion. Any practitioner using this code must document appropriate training and/or certification. Service is billed per report.\nConcepts: dynmc mshn X-ray nonspin.1rg (Computer-enhanced radiology)\tLanguage therapy (Speech pathology procedure)\tDecreased proportion of CD19+CD38+IgM+ cells (Finding)\tAre you currently immunodeficient (Intellectual Product)\tPerformedDiagnosis.diseaseStatusMissingReasonCode (Disease Status Missing Reason Code)", + "output": "dynmc mshn X-ray nonspin.1rg (Computer-enhanced radiology)" + }, + { + "input": "Definition: Amines described as a family of alicyclic hydrocarbons containing an amine group with the general formula R-C6H10NH2.\nConcepts: Ongoing loss of nerve cells (Central Nervous System)\tTreatment Emergent Flag (Conceptual Entity)\tCyclohexylamine (Cyclohexanes)\tStaphylococcus gallinarum (Staphylococcus, coagulase negative)\tNPS - Tell Us How Intense Your Pain Is (NPS Questionnaire Question)", + "output": "Cyclohexylamine (Cyclohexanes)" + }, + { + "input": "Definition: Aplasia/Hypoplasia of the 5th finger described as hypoplasia (congenital reduction in size) of the fifth finger, also known as the little finger.\nConcepts: Liposarcoma morphology (liposarcoma)\tLEC-5 Standard Version - Sudden Accidental Death: Not Apply (LEC-5 Standard Version Questionnaire Question)\tShort 5th fingers (Congenital Abnormality)\tPKC deactivation (regulation of G protein-coupled receptor signaling pathway)\tVaginal atresia (Congenital Abnormality)", + "output": "Short 5th fingers (Congenital Abnormality)" + }, + { + "input": "Definition: Infusion procedures described as administration of medications or nutrients directly into the venous system.\nConcepts: receptor mediated endocytosis (Endocytosis)\tInfusion, intravenous (Therapeutic or Preventive Procedure)\tphosphatidic acid carrier activity (phospholipid transfer activity)\tHamano Tsukamoto syndrome (Disease or Syndrome)\tCD334 Gene Amplification (Cell or Molecular Dysfunction)", + "output": "Infusion, intravenous (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a radiograph obtained by tomography.\nConcepts: TT00420 (Aurora Kinase Inhibitor)\tPlaying tennis or racquetball (Intellectual Product)\tNorthern blotting (Molecular Probe Techniques)\tTomogram (Medical Image)\tEpendyma and Remnants of the Central Canal of the Spinal Cord (Membrane of the Brain or Spinal Cord)", + "output": "Tomogram (Medical Image)" + }, + { + "input": "Definition: something described as a plant genus in the family LILIACEAE generally growing in temperate areas. The word lily is also used in the common names of many plants of other genera that resemble true lilies. True lilies are erect perennial plants with leafy stems, scaly bulbs, usually narrow leaves, and solitary or clustered flowers.\nConcepts: UHDRS 1999 Version - ADL (UHDRS 1999 Version Clinical Classification Question)\tsurgical incision (Operations, procedures and interventions)\tastragalus mollissimus/purpl (Homeopathic remedies letter A)\tFAC063-Have Joint Pain or Muscle Cramps (Intellectual Product)\tLilium L. (Plant)", + "output": "Lilium L. (Plant)" + }, + { + "input": "Definition: Quantitative Concept described as micromoles per liter (concentration), divided by milligrams per kilogram per day (daily dose normalized by body weight) or nanomoles per liter (concentration), divided by micrograms per kilogram per day (daily dose normalized by body weight).\nConcepts: congenital blood protein disorder (congenital blood disorder)\tPhysical anatomical entity (Physical object)\tbfeedbck montrng ea.session (PSYCHOLOGIC AND PSYCHIATRIC PROCEDURES AND SERVICES)\tJuxtaarticular Myxoma (Myxoma)\tnmol/L/(ug/kg/d) (Quantitative Concept)", + "output": "nmol/L/(ug/kg/d) (Quantitative Concept)" + }, + { + "input": "Definition: Gene or Genome described as a leftward transcribed region of the human herpesvirus-8 genome containing the immediate early genes ORF48 and ORF29b.\nConcepts: FAC084-Part I: Walk for 1/2 Mile Why Not (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)\tLichen sclerosus of penis (Other disorders of penis)\tSarcoma of the Orbit pTX TNM Finding v7 (Finding)\tKaposi's Sarcoma-Associated Herpesvirus Immediate-Early Region-4 Gene Locus (Gene or Genome)\tAscites drainage (Drainage to evacuate)", + "output": "Kaposi's Sarcoma-Associated Herpesvirus Immediate-Early Region-4 Gene Locus (Gene or Genome)" + }, + { + "input": "Definition: regulation of nuclear migration during mitotic telophase described as any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration during mitotic telophase.\nConcepts: down-regulation of nuclear migration during mitotic telophase (negative regulation of nuclear migration along microtubule)\tmiddiastolic murmur (Finding)\tGLAND, COAGULATING (Body Part, Organ, or Organ Component)\tcereus giganteus/saguaro (Flower Essences)\tEmbryonal Carcinoma of the Sellar Region (Central Nervous System Embryonal Carcinoma)", + "output": "down-regulation of nuclear migration during mitotic telophase (negative regulation of nuclear migration along microtubule)" + }, + { + "input": "Definition: something described as problem associated with perforations that lead to bursting of the device.\nConcepts: ABVD Regimen (Therapeutic or Preventive Procedure)\tPrior Medication Usage (Event)\tMMS104AA (MMSE Functional Test Question)\tdura mater (Membrane of the Brain or Spinal Cord)\tMaterial Rupture (Finding)", + "output": "Material Rupture (Finding)" + }, + { + "input": "Definition: something described as facilitating the patient to perceive, appreciate, and express what is funny, amusing, or ludicrous in order to establish relationships, relieve tension, release anger, facilitate learning, or cope with painful feelings\nConcepts: 46XY (Genotype)\tseaweed (Algae)\tHaemophilus haemolyticus, Penicillinase Positive (Haemophilus haemolyticus)\tHumor therp ndvdl ea.15min (Coping Assistance)\tAtadenovirus (Virus)", + "output": "Humor therp ndvdl ea.15min (Coping Assistance)" + }, + { + "input": "Definition: C-terminal protein amino acid modification described as the removal of a C-terminal, gene-encoded glutamate residue from a protein.\nConcepts: streptococcus group b (Lancefield group streptococcus)\tGallbladder Cancer Clinical TNM Finding v7 (Gallbladder Cancer TNM Finding v7)\tApplication Program Freezes, Becomes Nonfunctional (Application Program Issue Associated with Medical Device)\tLight Sources, Flexible Endoscope, Direct Attachment (Light Sources, Endoscope, Direct Attachment)\tprotein primary sequence deglutamylation (C-terminal protein amino acid modification)", + "output": "protein primary sequence deglutamylation (C-terminal protein amino acid modification)" + }, + { + "input": "Definition: something described as the smallest particle of a substance that retains the chemical and physical properties of the substance\nConcepts: Strong Opioids Less than or Equal to 75 mg Oral Morphine Equivalent per Day (Finding)\tpupillography (Diagnostic Techniques, Ophthalmological)\tMolecule (Elementary Particles)\tSevere Mosquito Bite Allergy (Atypical lymphoproliferative disorder)\tProduct Type Code (Type Code)", + "output": "Molecule (Elementary Particles)" + }, + { + "input": "Definition: something described as vaccines or candidate vaccines used to prevent infections with STREPTOCOCCUS PNEUMONIAE.\nConcepts: Branch (Polymers)\tXanthobacter (Xanthobacteraceae)\tLocally Advanced Ovarian Carcinoma (Stage IV Ovarian Carcinoma)\tFMN binding (Molecular Function)\tPNEUMOCOCCAL VACCINE (Pharmacologic Substance)", + "output": "PNEUMOCOCCAL VACCINE (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a type 2 angiotensin receptor.\nConcepts: PQL12-Hard to Gain/Lose Weight (Intellectual Product)\tPancreatic cysts (Mass of pancreas)\ttype 2 angiotensin receptor binding (Molecular Function)\tEC 3.4.19.- (Biologically Active Substance)\tmetanephric distal convoluted tubule development (Organ or Tissue Function)", + "output": "type 2 angiotensin receptor binding (Molecular Function)" + }, + { + "input": "Definition: Statistical Probability described as the ability of a statistic to reject a false hypothesis.\nConcepts: fluciclatide (Indicator, Reagent, or Diagnostic Aid)\terodium cicutarium/hemlock s (Organic Chemical)\ttype 2 correct determination probability (Research Activity)\tThlaspi (Thlaspideae)\tplasma membrane ATP synthesis coupled electron transport (ATP synthesis coupled electron transport)", + "output": "type 2 correct determination probability (Research Activity)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Arcanobacterium haemolyticum.\nConcepts: Stage II Diffuse Large Cell Lymphoma (Neoplastic Process)\tSolution for blood fraction modification (Solution Dosage Form)\txylene breakdown (aromatic compound catabolic process)\tArcanibacterium haemolyticum (Bacterium)\tMalignant Tumor of the Anterior Urethra (Malignant neoplasm of urethra)", + "output": "Arcanibacterium haemolyticum (Bacterium)" + }, + { + "input": "Definition: Retroperitoneal Neoplasms described as a solid, unencapsulated tumor of the KIDNEY composed of spindle mesenchymal cells that resemble FIBROBLASTS or muscle cells. The homogeneous mass typically extends into the renal parenchyma and replaces most of the kidney. In most cases, mesoblastic nephroma is benign and occurs in the fetus or newborn, and rarely in the older child or the adult.\nConcepts: Had Trouble Pronouncing Words (Intellectual Product)\tCystic pattern on pulmonary HRCT (Finding)\tNephroma, Mesoblastic (Neoplasm of uncertain or unknown behavior of kidney)\tmir-135b (MIR135B gene)\tnifedipine, micronized (nifedipine)", + "output": "Nephroma, Mesoblastic (Neoplasm of uncertain or unknown behavior of kidney)" + }, + { + "input": "Definition: Plastics described as any material made from or containing natural latex in its native liquid or colloidal state. Natural latex is an extract of the rubber tree (H. brasiliensis) and contains the allergens responsible for latex hyper-sensitivity reactions. Products that may contain NRL are medical gloves and condoms. See 21 CFR 801.437 for full regulatory definition.\nConcepts: Antibody, Catalytic (Biologically Active Substance)\tTachycardia, Junctional Ectopic (Cardiac and vascular procedural complications)\trubber (Industrial product)\tcryotherapy (Procedure categorized by device involved)\tcollecting duct development (Organ or Tissue Function)", + "output": "rubber (Industrial product)" + }, + { + "input": "Definition: cysteine biosynthetic process described as the chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine.\nConcepts: cysteine synthesis via S-sulfo-L-cysteine (Molecular Function)\tPenile Cancer pT1b TNM Finding v8 (Penile Cancer pT1 TNM Finding v8)\tdownward deviation of eyes (Eye)\tL-valine transmembrane transport (valine transport)\t2-Ethyl-2-Phenylmalonamide (Malonates)", + "output": "cysteine synthesis via S-sulfo-L-cysteine (Molecular Function)" + }, + { + "input": "Definition: something described as a method for obtaining an optimal programming algorithm. Thousands of randomly created programs are progressively evolved over time using an evolutionary search based on the principle of survival of the fittest. Mechanisms include the equivalent of recombination, mutation, duplication, deletion, etc.\nConcepts: Feline Sarcoma Oncogene wt Allele (Gene or Genome)\tCromolyn product (Organic Chemical)\tGenetic Programming (Intellectual Product)\t1,2-Dibromo-3-Chloropropane (Saturated aliphatic hydrocarbon)\tPerformedObservation.focalDuration (Focal Duration)", + "output": "Genetic Programming (Intellectual Product)" + }, + { + "input": "Definition: Testicular and epididymal neoplasms described as a malignant germ cell tumor that arises from the testis and has spread to another anatomic site.\nConcepts: prenylcysteine biosynthetic process (Molecular Function)\tMetastatic Malignant Testicular Germ Cell Tumor (Malignant neoplasm of testis)\tBlood Protein Electrophoresis (Electrophoresis)\tAntimetabolite (agents used in body system disorders)\tPROSTHESIS, THIGH SOCKET, EXTERNAL COMPONENT (Medical Device)", + "output": "Metastatic Malignant Testicular Germ Cell Tumor (Malignant neoplasm of testis)" + }, + { + "input": "Definition: Cyclins described as a 50-kDa protein that complexes with CYCLIN-DEPENDENT KINASE 2 in the late G1 phase of the cell cycle.\nConcepts: scp (Cerebellar peduncle)\tThermal sensation (skin sense)\tHigh-Mobility Group Nucleosomal Binding Domain 2 Gene (Gene or Genome)\tcyclin e (Biologically Active Substance)\tnegative regulation of muscle hyperplasia (Physiologic Function)", + "output": "cyclin e (Biologically Active Substance)" + }, + { + "input": "Definition: Great Relative described as a female child of one's niece or nephew.\nConcepts: Grade 3 Paresthesia, CTCAE (Paresthesia, CTCAE)\tmentha-1,3-dione-CoA ligase activity (acid-thiol ligase activity)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Up 20 Stairs Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tGreat Niece (Family Group)\tAUC to Last Nonzero Conc, Unbound Drug (Area Under the Curve From Dosing to Last Concentration)", + "output": "Great Niece (Family Group)" + }, + { + "input": "Definition: something described as the process in which a tricarboxylic acid is transported across a membrane.\nConcepts: PROCESSOR, CINE FILM (X-Ray Film Processors, Automatic)\tlipemia-clearing factor (triglyceride lipase activity)\tDRRI1-M: Family Got Into Trouble (DRRI-2 Questionnaire Question)\ttricarboxylic acid membrane transport (tricarboxylic acid transport)\t22: 28967302-28960997 (Chromosome 22 Physical Location)", + "output": "tricarboxylic acid membrane transport (tricarboxylic acid transport)" + }, + { + "input": "Definition: Tectal plate described as either of the superior (rostral) pair of rounded eminences symmetrically located in the tectum of the mesencephalon, containing reflex centers for visual sensations.\nConcepts: FEDERAL HEALTH CARE FACILITY (Health care facility)\tdorsal claustrum (Basal Ganglia, Claustrum, Internal and External Capsules)\tendopiriform nucleus dorsal part (Body Part, Organ, or Organ Component)\tStructure of superior colliculus of corpora quadrigemina (Tectum Mesencephali)\tBoolean Value (Any)", + "output": "Structure of superior colliculus of corpora quadrigemina (Tectum Mesencephali)" + }, + { + "input": "Definition: ObservationMethod - CodeSystem described as a method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions.\nConcepts: Mass to volume ratio (Kind of quantity)\tBrushes, Surgical, Bone, Intramedullary, Femoral Canal (Medical Device)\tBioassays (Chemical method)\tFollicular Lymphoma Grade 3b (Lymphoma, Large-Cell, Follicular)\tPineal structure (Circumventricular organ of neuraxis)", + "output": "Bioassays (Chemical method)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of ampulla of Vater cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of regional lymph nodes.\nConcepts: Abstinence (Thesaurus of Psychological Index Terms)\tNPC assembly (Cell Function)\tAmpulla of Vater Cancer Pathologic Regional Lymph Nodes TNM Finding v8 (Ampulla of Vater Cancer Pathologic TNM Finding v8)\tClosed-loop insulin infusion system (Medical Device)\tRAD50 DEFICIENCY (Congenital anomaly of brain)", + "output": "Ampulla of Vater Cancer Pathologic Regional Lymph Nodes TNM Finding v8 (Ampulla of Vater Cancer Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Systemic Therapy described as a type of radiation therapy in which a radioactive substance, such radioactive iodine or a radioactively labeled monoclonal antibody, is swallowed or injected into the body and travels through the blood, locating and killing tumor cells.\nConcepts: MRD17 (Syndrome)\tPeritoneal Dialysis Catheters (Peritoneal catheter)\tInjectable (Pharmacologic Substance)\tsystemic radiation therapy (Therapeutic radiology procedure)\tRoot of sacral nerve (Lumbosacral spinal cord nerve root)", + "output": "systemic radiation therapy (Therapeutic radiology procedure)" + }, + { + "input": "Definition: something described as cell-cell signaling in which the ligand is carried between cells by an exosome.\nConcepts: exosome mediated (Cell Function)\terotica (Publications)\tRelaxation Technic (Behavior Therapy)\tapurinic/apyrimidinic endoribonuclease activity (Genetic Function)\tup-regulation of chronic inflammatory response to antigenic stimulus (regulation of chronic inflammatory response to antigenic stimulus)", + "output": "exosome mediated (Cell Function)" + }, + { + "input": "Definition: Enzyme described as histone acetyltransferase KAT6A (2004 aa, ~225 kDa) is encoded by the human KAT6A gene. This protein is a histone acetyltransferase that is involved in the regulation of transcription.\nConcepts: viral attachment to host adhesion receptor (Cell Function)\tMYST Protein 3 (Enzyme)\tATPase-coupled cadmium transmembrane transporter activity (Molecular Function)\tsbsqnt15min inofc homeo ntak (Health Care Activity)\tRing Finger Protein 43 Gene c.461C>T (RNF43 Gene Mutation)", + "output": "MYST Protein 3 (Enzyme)" + }, + { + "input": "Definition: Intellectual Product described as an identifier that describes the relative position of an exposure data within a series.\nConcepts: isotype switching to IgA isotypes (Genetic Function)\tchromosome 5p tetrasomy syndrome (Disease or Syndrome)\tnegative regulation of sodium-dependent phosphate transport (negative regulation of anion transport)\tEXSEQ (Intellectual Product)\tnegative regulation of lymphocyte mediated immunity (Physiologic Function)", + "output": "EXSEQ (Intellectual Product)" + }, + { + "input": "Definition: Method of administration of drug described as administration of drugs or chemicals by one's self. Used clinically or experimentally for humans or animals. Not to be confused with SELF MEDICATION.\nConcepts: major histocompatibility complex class II biosynthesis (macromolecule biosynthetic process)\tDistal region of muscle organ (Body Location or Region)\tAdministration, Self (Method of administration of drug)\tMinimal Response of Multiple Myeloma (Finding)\t(3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide (Cardiovascular Agents)", + "output": "Administration, Self (Method of administration of drug)" + }, + { + "input": "Definition: Abnormal mitochondrial shape described as the mitochondrial matrix refers to the substance occupying the space enclosed by the inner membrane of a mitochondrion, which contains enzymes, DNA, granules, and inclusions of protein crystals, glycogen, and lipid. Mitochondrial swelling refers to an increase in size of the mitochondrial matrix. This phenomenon is thought to be related to a permeabilized inner membrane that originates a large swelling in the mitochondrial matrix. Mitochondrial swelling may distend the outer membrane until it ruptures.\nConcepts: PQL02-Get Sores and/or Rashes (Intellectual Product)\tMen who have Sex with Men (Population Group)\tRadiation Cerebritis (Injury or Poisoning)\tSwellings, Mitochondrial (Cell Physiological Processes)\tFood and Beverage Serving Workers (Professional or Occupational Group)", + "output": "Swellings, Mitochondrial (Cell Physiological Processes)" + }, + { + "input": "Definition: something described as an arbitrary unit of substance content expressed in units of biological activity per 10^12 red blood cells.\nConcepts: Chenodeoxycholic acid product (Dihydroxy bile acid)\tFifth lumbar spinous process (Body Part, Organ, or Organ Component)\tng/ml/(ug/kg) (Unit of concentration)\tHorizontal Canal (Body Part, Organ, or Organ Component)\tU/10*12{RBC} (Arbitrary Unit of Substance Rate)", + "output": "U/10*12{RBC} (Arbitrary Unit of Substance Rate)" + }, + { + "input": "Definition: something described as this gene is involved in the modulation of gene transcription.\nConcepts: Nongrowing End of Microtubule (microtubule end)\tdeletion 2q syndrome (Disease or Syndrome)\tEDG1 (Transcription Regulation Gene)\tImpaired continence (Impairment of activities of daily living)\tMoxalactam-containing product (Antibiotic)", + "output": "EDG1 (Transcription Regulation Gene)" + }, + { + "input": "Definition: Catarrhini described as a taxonomic family that was originally restricted to humans and their extinct relatives, but now also includes the gorilla, orangutan, chimpanzee and bonobo.\nConcepts: L-lysine oxidase activity (Molecular Function)\tHypermethioninaemia due to S-adenosylhomocysteine hydrolase deficiency (Hypermethioninemia)\thominidae (Hominoidea)\tAbacavir sulfate + lamivudine + zidovudine (abacavir / lamivudine)\tvidarabine anhydrous (Purine antagonist)", + "output": "hominidae (Hominoidea)" + }, + { + "input": "Definition: something described as a clinical study that includes all eligible patients identified by the researchers during the study registration period. The patients are treated in the order in which they are identified. This type of study usually does not have a control group.\nConcepts: consecutive case series (Research Activity)\tcalcium-dependent cell-matrix adhesion (Cell-Matrix Junction)\tSMO antagonist BMS 833923 (Organic Chemical)\tIVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis, Antigen (IVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis)\tAVL01-List A Recall 3 Word 14 (Intellectual Product)", + "output": "consecutive case series (Research Activity)" + }, + { + "input": "Definition: gallbladder and biliary tree disorders described as impairment of the bile flow caused by an obstruction in the portion of the bile duct system located outside of the liver.\nConcepts: 5-fluoro-5'-deoxyuridine (Pharmacologic Substance)\tT-helper 17 cell extravasation (Cell Function)\tup-regulation of asexual reproduction (regulation of asexual reproduction)\tBiliary Stasis, Extrahepatic (Finding of biliary tract)\tML (National Drug Code Unit of Measure)", + "output": "Biliary Stasis, Extrahepatic (Finding of biliary tract)" + }, + { + "input": "Definition: Finding described as an increased number of mitochondria detected in neutrophils.\nConcepts: Increased neutrophil mitochondria (Abnormality of neutrophil morphology)\tKindergarten Students (Population Group)\tPirazmonam Sodium (Monobactams)\tMinimal Residual Disease Sample Source (Finding)\tTHYROID DYSGENESIS (Abnormality of thyroid morphology)", + "output": "Increased neutrophil mitochondria (Abnormality of neutrophil morphology)" + }, + { + "input": "Definition: Teratoma described as a teratoma located within the mediastinum (the cavity between the pleural sacs that contains the heart and all of the thoracic viscera except the lungs).\nConcepts: satisfaction client (Health Care Evaluation Mechanisms)\tMixed Exocrine-Endocrine Carcinoma of the Pancreas (Gastrointestinal Mixed Adenoneuroendocrine Carcinoma)\tTeratoma of the Mediastinum (Mediastinal Germ Cell Tumor)\tChlorambucil Plus Rituximab (Regimen Used to Treat Non-Hodgkin Lymphoma)\tdownregulation of cardiac muscle fiber development (Physiologic Function)", + "output": "Teratoma of the Mediastinum (Mediastinal Germ Cell Tumor)" + }, + { + "input": "Definition: Benzoic acid ester and benzoic acid ester derivative described as the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodium channels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation.\nConcepts: Assesses patient and designated support person's educational needs (Behavioral Responses: Patient and Family - Knowledge/Psychosocial)\tcranial suture morphogenesis (Organism Function)\tAccomplished less than you would like (Intellectual Product)\tProcaine Hydrochloride (aniline)\tClinical Observation (Diagnostic tests)", + "output": "Procaine Hydrochloride (aniline)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen-containing compound stimulus.\nConcepts: response to oxygen-containing compound (Cell Function)\tIntra-pelvic structure of true pelvis (Intra-abdominopelvic structure)\tGrade 1 Bruising, CTCAE (Finding)\tChief Complaint Present in the Evening (Chief complaint)\tBone-in-Bone Sign (Radiologic finding)", + "output": "response to oxygen-containing compound (Cell Function)" + }, + { + "input": "Definition: something described as cancer is found in the cervix only. Stage I is divided into stages IA and IB, based on the amount of cancer that is found. In stage IA, a very small amount of cancer that can only be seen with a microscope is found in the tissues of the cervix. The cancer is not deeper than 5 millimeters and not wider than 7 millimeters. In stage IB, the cancer is still within the cervix and either (1) can only be seen with a microscope and is deeper than 5 millimeters or wider than 7 millimeters; or (2) can be seen without a microscope and may be larger than 4 centimeters.\nConcepts: IVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Comprehensive, Mutation (Medical Device)\tBlasts 1 Percent of Peripheral Blood White Cells (Laboratory or Test Result)\tCorynebacterium preisz-nocardi (Bacterium)\tCDISC ADAS-Cog - Orientation Summary Score (Intellectual Product)\tStage I Cervical Cancer AJCC v6 and v7 (Cervical Cancer by AJCC v7 Stage)", + "output": "Stage I Cervical Cancer AJCC v6 and v7 (Cervical Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: Echocardiogram abnormal described as a diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.\nConcepts: MDS-UPDRS - Rest Tremor Amplitude Right Lower Extremity (MDS-UPDRS Questionnaire Question)\tReduced ejection fraction (Finding)\tpositive pregnancy tests (Urogenital finding)\tcellular alkene metabolic process (Metabolic Process, Cellular)\tAnalysis and interpretation of laboratory findings each report (Analysis and/or documentation services with or without ICD diagnosis)", + "output": "Reduced ejection fraction (Finding)" + }, + { + "input": "Definition: alpha-beta T cell activation involved in immune response described as the expansion of an alpha-beta T cell population by cell division as part of an immune response.\nConcepts: Purchasing, Group (Health Care Activity)\tEwing Sarcoma (NCI CTEP SDC Bone Neoplasm Category Terminology)\tr(6) syndrome (Chromosome replaced with ring or dicentric)\talpha-beta T cell proliferation involved in immune response (T cell proliferation involved in immune response)\tUnipolar Depressions (Mental Depression)", + "output": "alpha-beta T cell proliferation involved in immune response (T cell proliferation involved in immune response)" + }, + { + "input": "Definition: Mutation described as process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.\nConcepts: Mutagenesis (Genetic Processes)\tDistractors, Surgical, Ankle (Medical Device)\tPrevention Research (Research Activities)\tDomestication (Thesaurus of Psychological Index Terms)\tcprhnsv male horm.prfle ea.t (Laboratory Procedure)", + "output": "Mutagenesis (Genetic Processes)" + }, + { + "input": "Definition: Laboratory Procedure described as a procedure to ascertain the level of antigen in a specimen.\nConcepts: Respiratory syncytial virus antigen level (Viral antigen assay)\tEnterobacteriaceae (ex Rahn 1937) Ewing et al. 1980 (Coliform bacteria)\tbutyryl-CoA biosynthesis from acetyl-CoA (butyryl-CoA biosynthetic process)\tL-glutamate import into mitochondrion (mitochondrial transmembrane transport)\tStudy of Disease Mechanisms (Study)", + "output": "Respiratory syncytial virus antigen level (Viral antigen assay)" + }, + { + "input": "Definition: Alkyl and Aryl Transferases described as an enzyme that catalyzes the biosynthesis of cysteine in microorganisms and plants from O-acetyl-L-serine and hydrogen sulfide. This enzyme was formerly listed as EC 4.2.99.8.\nConcepts: regulation of nuclear size (Physiologic Function)\tAverage Concentration from T1 to T2 (Quantitative Concept)\tmedulloblastoma brain tumor (Medulloblastoma)\tO Acetylserine Sulfhydrylase (Enzyme)\tTF Positive (Laboratory or Test Result)", + "output": "O Acetylserine Sulfhydrylase (Enzyme)" + }, + { + "input": "Definition: something described as an assay that measures the proliferative response of lymphocytes from one individual when they are exposed to inactivated lymphocytes from another individual. The reaction can be performed on lymphocytes from the same individual (auto-MLR), from different individuals of the same species (allo-MLR), or individuals from different species (xeno-MLR). It is used to evaluate the potential for graft-versus-host or host-versus-graft reactions during transplantation procedures involving mismatched tissue types or individuals.\nConcepts: Bilophila (Desulfovibrionaceae)\tcell germ ovaries tumors (Gonadal Disorders)\tMLC assay, NOS (Immunologic identification of antigen or antibody)\tARCHITECTURAL ACCESS (Qualitative Concept)\tShunt Thrombosis (Non-site specific procedural complications)", + "output": "MLC assay, NOS (Immunologic identification of antigen or antibody)" + }, + { + "input": "Definition: something described as human IL7R wild-type allele is located within 5p13 and is approximately 20 kb in length. This allele, which encodes interleukin-7 receptor alpha chain protein, is involved in V(D)J recombination during lymphocyte development.\nConcepts: Gram (SI unit of mass)\tVisual Tracking (psychomotor tracking)\tCD127 (IL7R gene)\tSignet Ring Adenocarcinoma of Rectum (Colorectal Signet Ring Cell Carcinoma)\tProduct containing oprelvekin (Recombinant Interleukins)", + "output": "CD127 (IL7R gene)" + }, + { + "input": "Definition: Peripheral embolism and thrombosis described as a condition that is caused by recurring atheroembolism in the lower extremities. It is characterized by cyanotic discoloration of the toes, usually the first, fourth, and fifth toes. Discoloration may extend to the lateral aspect of the foot. Despite the gangrene-like appearance, blue toes may respond to conservative therapy without amputation.\nConcepts: Powder and solvent for solution for infusion (Combined Dosage Form)\tPerformed Material Storage (Material Storage)\tMitochondrial Transmembrane Permeability Driven Necrosis (Cell Function)\t4-hydroxyphenylacetate transmembrane transporter activity (organic hydroxy compound transmembrane transporter activity)\tBlue Toe Syndrome (Cholesterol Embolism)", + "output": "Blue Toe Syndrome (Cholesterol Embolism)" + }, + { + "input": "Definition: Collection Date Time described as the date and time morphology data was collected.\nConcepts: Transport protein, NOS (Functional Immunologic Units)\tXenygloxal (Pharmacologic Substance)\tFAC01542 (FACT-HEP Version 4 Questionnaire Question)\tMorphology Data Collection Date Time (Collection Date Time)\tChemical Carcinogenesis (Neoplastic Process)", + "output": "Morphology Data Collection Date Time (Collection Date Time)" + }, + { + "input": "Definition: Disease or Syndrome described as inflammed tongue with hyperplastic (enlarged) fungiform papillae that is said to resemble a strawberry or raspberry.\nConcepts: Rana clamitans Latreille, 1801 (Aquarana)\tCutaneous Melanoma pN3a TNM Finding v8 (Finding)\tInvasive haemodynamic monitoring (Therapeutic or Preventive Procedure)\tStrawberry tongue (Tongue signs and symptoms)\tSGRQ-C - Cannot Take a Bath or Shower (Intellectual Product)", + "output": "Strawberry tongue (Tongue signs and symptoms)" + }, + { + "input": "Definition: something described as thrombotic disorders are diseases characterized by formation of a thrombus that obstructs vascular blood flow locally or detaches and embolizes to occlude blood flow downstream. Embolism is the sudden blocking of a vessel by a clot or foreign material which has been brought to its site of lodgement by the blood current. (Thrombo-)phlebitis is an inflammation of a vein (phlebitis) associated with thrombus formation (thrombosis).\nConcepts: SubstanceExtractionAdministrationRelationship (Relationships)\tendobronchial ultrasonography (Ultrasonography of thorax)\tPASTEURELLA AEROGENES (aerogenes-[Pasteurella] mairii-[Actinobacillus] rossii complex)\tlymphangiectasia (Angiectasis)\tEmbolic and thrombotic events (Classification)", + "output": "Embolic and thrombotic events (Classification)" + }, + { + "input": "Definition: Virus described as genus in the family Orthomyxoviridae causing influenza and other diseases in humans and animals; contains many strains as well as antigenic subtypes of the integral membrane proteins hemagglutinin and neuraminidase.\nConcepts: Influenzavirus A (Influenza virus)\tJust hearing the words \"prostate cancer\" scared me (Intellectual Product)\tPenile pain (Finding)\tVery often indeed (Temporal Qualifier)\tPharmaceutic Education, Continuing (Educational Activity)", + "output": "Influenzavirus A (Influenza virus)" + }, + { + "input": "Definition: Neuroendocrine carcinoma of prostate described as an exceptionally rare neuroendocrine carcinoma that arises from the prostate gland. It is characterized by the presence of malignant large cells.\nConcepts: Prostate Large Cell Neuroendocrine Carcinoma (Large cell neuroendocrine carcinoma)\tQ-LES-Q - Solved House Problems Without Stress (Q-LES-Q Questionnaire Question)\tIntervertebral disk prostheses (Medical Device)\tDRC3 (EPS8L1 gene)\tALS - Amyotrophic lateral sclerosis (Degenerative Diseases, Central Nervous System)", + "output": "Prostate Large Cell Neuroendocrine Carcinoma (Large cell neuroendocrine carcinoma)" + }, + { + "input": "Definition: Quantitative Concept described as a measure of the correlation of two variables X and Y measured on the same object or organism, that is, a measure of the tendency of the variables to increase or decrease together. It is defined as the sum of the products of the standard scores of the two measures divided by the degrees of freedom.\nConcepts: Lamina medullaris medialis of inferior colliculus (Body Part, Organ, or Organ Component)\tRAD51-like 3 (Gene or Genome)\tPearson Product Moment Correlation Coefficient (Statistical Technique)\tjudgment (Mental Process)\tIntraoesophageal route (Drug Administration Routes)", + "output": "Pearson Product Moment Correlation Coefficient (Statistical Technique)" + }, + { + "input": "Definition: Biologically Active Substance described as trans-activator protein BZLF1 (245 aa, ~27 kDa) is encoded by the Epstein-Barr virus BZLF1 gene. This protein is involved in the induction of both the expression of early lytic cycle genes and the replication of the viral genome.\nConcepts: mitochondrial mRNA processing (mitochondrial RNA processing)\tRisk for dysfunctional gastrointestinal motility (Finding)\tDRRI1-E: Observed Homes Been Destroyed (Intellectual Product)\tHave Trouble Finishing Things (Clinical or Research Assessment Question)\tEpstein-Barr Virus BZLF-1 (Amino Acid, Peptide, or Protein)", + "output": "Epstein-Barr Virus BZLF-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as nucleocytoplasmic transport molecules that bind to ALPHA KARYOPHERINS in the CYTOSOL and are involved in transport of molecules through the NUCLEAR PORE COMPLEX. Once inside the CELL NUCLEUS beta karyopherins interact with RAN GTP-BINDING PROTEIN and dissociate from alpha karyopherins. Beta karyopherins bound to RAN GTP-BINDING PROTEIN are then re-transported to the cytoplasm where hydrolysis of the GTP of RAN GTP-BINDING PROTEIN causes release of karyopherin beta.\nConcepts: h.mol/L/(kg/m2) (Quantitative Concept)\tHemoglobin B Measurement (Hemoglobin measurement)\tKap95 protein (Biologically Active Substance)\tpositive regulation of reciprocal meiotic recombination (regulation of reciprocal meiotic recombination)\tDidemnin (Immunosuppressive Agents)", + "output": "Kap95 protein (Biologically Active Substance)" + }, + { + "input": "Definition: Immunologic Factor described as a radioimmunoconjugate of a murine whole immunoglobulin G monoclonal antibody MAb-170 labeled with Technetium 99m (Tc-99m). MAb-170, originally raised against a carbohydrate epitope (a synthetic Thomsen-Friedenreich antigen), has been found to have panadenocarcinoma affinity, including adenocarcinomas of breast, fallopian tube, colon, endometrium, prostate, bladder, liver, lung, and ovary. Tc-99m MAb-170 delivers gamma emission Tc-99m nuclide directly to adenocarcinoma tissues, thereby this agent may be used for diagnostic or imaging purposes.\nConcepts: Avastrovirus (Virus)\tTc 99m Monoclonal Antibody 170 (Immunologic Factor)\tJob Decision Latitude (Idea or Concept)\tBlood Drawing Stations (Casework and Furniture)\thistone demethylase activity (histone demethylase activity)", + "output": "Tc 99m Monoclonal Antibody 170 (Immunologic Factor)" + }, + { + "input": "Definition: Disease or Syndrome described as a seizure precipitated by movement or a change in posture.\nConcepts: Bone Cancer pNX TNM Finding v8 (Finding)\tTumor or Lesion Properties Test Result (CDISC SDTM Terminology)\tProprioceptive-induced seizure (Disease or Syndrome)\tStage IIIC1 (Classification)\tSarcoma by FNCLCC Grade (Sarcoma)", + "output": "Proprioceptive-induced seizure (Disease or Syndrome)" + }, + { + "input": "Definition: Apnea, CTCAE described as present; medical intervention indicated\nConcepts: Teaching: Prescribed Medication (drug management)\tGrade 3 Apnea, CTCAE (Finding)\tFibrocartilage, NOS (Cartilage)\tHow motivated are you to exercise (Clinical or Research Assessment Question)\tFactor D, complement component (Serine Endopeptidases)", + "output": "Grade 3 Apnea, CTCAE (Finding)" + }, + { + "input": "Definition: Goldenhar Syndrome described as an extremely rare syndrome with characteristics of multiple unerupted permanent teeth, hypoplasia of the alveolar process and of the maxillo-zygomatic region, severe genu valgum and deformed ears. Consanguinity in the family suggested autosomal recessive inheritance.\nConcepts: Non-eruption of teeth, maxillary hypoplasia, genu valgum syndrome (Congenital anomaly of jaw)\tGLYCERALDEHYDEPHOSPHATE DE NADP P 03 (Enzyme)\ttemperature receptor (Sensory Receptor Cells)\tFoveal hypopigmentation (Abnormality of foveal pigmentation)\tClinical Trial Investigator Site Documentation (Intellectual Product)", + "output": "Non-eruption of teeth, maxillary hypoplasia, genu valgum syndrome (Congenital anomaly of jaw)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: 2,6-dioxo-6-phenylhexanoate + NADP(+) = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H(+) + NADPH.\nConcepts: 2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity (Molecular Function)\tStage III Skin Carcinoma (Neoplastic Process)\tFundus Uterus (Uterus)\tTotivirus (Totiviridae)\tBenign Mediastinal Germ Cell Neoplasm (Neoplastic Process)", + "output": "2-hydroxy-6-oxo-phenylhexa-2,4-dienoate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity (Molecular Function)" + }, + { + "input": "Definition: Stage II Pancreatic Cancer AJCC v8 described as stage IIA includes: T3, N0, M0. T3: Tumor measuring more than 4 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Stage IIA Exocrine Pancreatic Carcinoma AJCC v8 (Stage II Pancreatic Cancer AJCC v8)\tasparagine-oxo-acid aminotransferase activity (aminotransferase activity)\tLEUKEMIA, ACUTE PROMYELOCYTIC (leukemia)\tNeedle Cappers (Medical Device)\tExocrine Pancreatic Cancer Clinical Distant Metastasis TNM Finding v8 (Exocrine Pancreatic Cancer Clinical TNM Finding v8)", + "output": "Stage IIA Exocrine Pancreatic Carcinoma AJCC v8 (Stage II Pancreatic Cancer AJCC v8)" + }, + { + "input": "Definition: Languages described as work consisting of common terms, phrases, idioms, and typical conversations, e.g., between health professional and patients. These are often intended for use by non-native speakers of a language.\nConcepts: Vadacabtagene Leraleucel (Chimeric Antigen Receptor T-cells)\tSubchorionic haematoma (Disorder of extraembryonic membrane)\tSocial Skills (Intellectual Product)\tRelapsed Grade II Follicular Lymphoma (Recurrent Follicular Lymphoma)\tPhrases (Intellectual Product)", + "output": "Phrases (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as an oral proprietary P-glycoprotein (P-gp) pump inhibitor-based formulation containing the taxane docetaxel, a semisynthetic analogue of paclitaxel, and a P-gp pump inhibitor, with potential antineoplastic activity. Upon administration of oral docetaxel, the P-gp pump inhibitor moiety, which is not absorbed, binds to the P-gp pump in the gastrointestinal (GI) tract and prevents the P-gp pump-mediated efflux of docetaxel from cells the docetaxel has been internalized by back into the GI tract. This decreases P-gp-mediated excretion and enhances absorption of docetaxel. Upon absorption, docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizes tubulin and inhibits microtubule disassembly, which results in cell-cycle arrest at the G2/M phase and cell death. The P-gp pump inhibitor enhances the bioavailability of certain poorly bioavailable agents and thereby allows oral administration of those agents. P-gp, an efflux membrane transporter, plays a key role in active drug export, and prevents cellular uptake and accumulation of certain substances.\nConcepts: SEND IG DART Version 1.1 (Version)\tMHC protein complex assembly (cellular protein-containing complex assembly)\tDandelions (Crepidinae)\tFN14 (Gene or Genome)\tdocetaxel-P-glycoprotein inhibitor (Organic Chemical)", + "output": "docetaxel-P-glycoprotein inhibitor (Organic Chemical)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a solution, which after usually being administered in a drop-wise fashion, forms a gel.\nConcepts: FREE RADICAL ASSAY, METHADONE (Indicator, Reagent, or Diagnostic Aid)\tregulation of resting membrane potential (Cell Function)\tsuccinate membrane transport (drug transmembrane transport)\tSevere conductive hearing impairment (Conductive hearing loss)\tSOLUTION, GEL FORMING / DROPS (Biomedical or Dental Material)", + "output": "SOLUTION, GEL FORMING / DROPS (Biomedical or Dental Material)" + }, + { + "input": "Definition: Absence Seizures described as an absence with eyelid myoclonia seizure is a type of generalized non-motor (absence) seizure characterised by forced upward jerking of the eyelids during an absence seizure.\nConcepts: posterior spino-olivary tract of the spinal cord (Body Part, Organ, or Organ Component)\t5'-3' Exoribonuclease 2 Gene (Ribonuclease Gene)\tPrimary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma M0 TNM Finding v8 (Primary Cutaneous B-Cell/T-Cell (Non-MF/SS) Lymphoma Distant Metastasis TNM Finding v8)\tAbsence seizures with eyelid myoclonia (Eyelid myoclonia seizure)\tViral Genetics (Science of Microbial Genetics)", + "output": "Absence seizures with eyelid myoclonia (Eyelid myoclonia seizure)" + }, + { + "input": "Definition: something described as a geographic area displaying a higher-than-expected rate of cancer incidence.\nConcepts: FLOT1 wt Allele (FLOT1 gene)\tcancer cluster (Hot Spots)\tStatic Light Scattering (Light Scattering)\tNPI1J09 (NPI Questionnaire Question)\tAdapter Protein Gene (Gene or Genome)", + "output": "cancer cluster (Hot Spots)" + }, + { + "input": "Definition: Disease or Syndrome described as a syndromic developmental defect of the eye with characteristics of dislocated or subluxated crystalline lenses, anterior segment abnormalities, and distinctive facial features such as flat cheeks and a prominent, beaked nose. Affected individuals may develop nontraumatic conjunctival cysts, also referred to as filtering blebs. There is evidence the syndrome is caused by homozygous mutation in the ASPH gene on chromosome 8q12.\nConcepts: SHAWAF-TRABOULSI SYNDROME (Disease or Syndrome)\trested (Daily or Recreational Activity)\tclinical course (Signs and Symptoms)\tBoykin Spaniel (Mammal)\tApheresis Units, Therapeutic, Phototherapy (Medical Device)", + "output": "SHAWAF-TRABOULSI SYNDROME (Disease or Syndrome)" + }, + { + "input": "Definition: something described as an integrin complex that comprises one alpha3 subunit and one beta1 subunit.\nConcepts: SET, GAVAGE, INFANT, STERILE (Medical Device)\tfibroblast growth factor receptor signalling pathway involved in mammary gland specification (fibroblast growth factor receptor signaling pathway)\tPerformed Activity Order Date (Order Date)\tBCLAF1 Gene (Gene or Genome)\tVLA-3 complex location (Cell Component)", + "output": "VLA-3 complex location (Cell Component)" + }, + { + "input": "Definition: Psychological therapies described as interventions to reinforce or promote desirable cognitive functioning or alter undesirable cognitive functioning\nConcepts: Cardiovascular Abnormalities (Phenotypic abnormality)\tExperimental Organism Malignant Neuroepithelial Carcinoma (Neoplastic Process)\tDay Times Mole per Liter per Kilogram per Meter Squared (Quantitative Concept)\tLARYNX, ARTIFICIAL (Medical Device)\tcognitive behavior therapy (Cognitive Techniques)", + "output": "cognitive behavior therapy (Cognitive Techniques)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of iris melanoma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.\nConcepts: negative regulation of macrophage cytokine production (negative regulation of cytokine production involved in immune response)\tNSCLC103 (NSCLC-SAQ Version 1.0 Questionnaire Question)\tRoland Morris Disability Questionnaire Questionnaire Test Name (Intellectual Product)\tSolder Joint (Manufactured Object)\tIris Melanoma Pathologic Primary Tumor TNM Finding v8 (Finding)", + "output": "Iris Melanoma Pathologic Primary Tumor TNM Finding v8 (Finding)" + }, + { + "input": "Definition: negative regulation of animal organ morphogenesis described as any process that stops, prevents or reduces the frequency, rate or extent of apoptotic process involved in outflow tract morphogenesis.\nConcepts: Division Head (Professional or Occupational Group)\tnegative regulation of apoptotic process involved in outflow tract morphogenesis (negative regulation of apoptotic process involved in morphogenesis)\tNeurogenic Bowel (Gastrointestinal disorders NEC)\tRetinoblastoma-Binding Protein 4 (Transcription Regulatory Protein)\tTRAP150 (THRAP3 gene)", + "output": "negative regulation of apoptotic process involved in outflow tract morphogenesis (negative regulation of apoptotic process involved in morphogenesis)" + }, + { + "input": "Definition: Intellectual Product described as subcategory name for the eTMF domain containing a collection of Subject Tomography files for a specific study.\nConcepts: Global Assessment Variable (Study Variable)\tALK Intron 19 ATI Isoform Protein (Enzyme)\tRHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 28 (Signaling Pathway Gene)\tComputed Tomography Study File (Intellectual Product)\tIntrahepatic Bile Duct Cancer pT4 TNM Finding v7 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Computed Tomography Study File (Intellectual Product)" + }, + { + "input": "Definition: Finding described as urethral cancer with no regional lymph node metastasis.\nConcepts: Genus Ceratocystis (Fungus)\tScarring of kidney arteries (Urologic Diseases)\tPort-Wine Stains (Cutaneous vascular malformation)\tcolon structure (Large intestine part)\tUrethral Carcinoma pN0 TNM Finding v8 (Finding)", + "output": "Urethral Carcinoma pN0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Conversation and use of communication devices and techniques described as an extended communication (often interactive) dealing with some particular topic.\nConcepts: cemiplimab (Antineoplastic Antibody)\tGyrus fornicatus (Body Part, Organ, or Organ Component)\tVestibular nuclei (Pontine structure)\tgzip File Format (Format)\tDiscuss (Social Behavior)", + "output": "Discuss (Social Behavior)" + }, + { + "input": "Definition: Animal described as experimental organism whose genome has been altered by the transfer of a gene or genes from another species or breed.\nConcepts: Transgenic Animals (Animal)\tFoxes, Flying (Megachiroptera)\tPost-intervention (Imaging Techniques)\tCSS08-Aborted/Self-Interrupted Attempt (Intellectual Product)\tFAC030-I Am Losing Weight (NCCN-FACT FBRSI-24 Version 2 Questionnaire Question)", + "output": "Transgenic Animals (Animal)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of pheochromocytoma and paraganglioma, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.\nConcepts: 922 KERATOLYTIC AGENTS (Medicinal product categorized by therapeutic role)\tHand Digit 2 Phalanx (Body Part, Organ, or Organ Component)\tpyruvate transmembrane transport (carboxylic acid transmembrane transport)\tProstate Ductal Adenocarcinoma, Papillary Pattern (Neoplastic Process)\tAdrenal-Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Finding)", + "output": "Adrenal-Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as problems related to immunity or capabilities to resist electromagnetic interference (EMI).\nConcepts: Inadequate Device Immunity (Finding)\tAnalyzers, Point-of-Care, Whole Blood, Gas/pH/Electrolyte/Metabolite (Medical Device)\tBioluminescence Resonance Energy Transfer Techniques (Laboratory Procedure)\tgentiana quinqueflora/5 flow (Organic Chemical)\tPQL01-Hard for Family to Rest (Intellectual Product)", + "output": "Inadequate Device Immunity (Finding)" + }, + { + "input": "Definition: Lichen Planus described as a rare variant of cutaneous lichen planus with the presence of hyperpigmented lichenoid lesions in sun-exposed or flexural areas of the body. A rare disease in Europe but it is common in Indian populations and in the Middle East. The overall prevalence is unknown. There is no difference in distribution between males and females. The disease usually appears in the third and fourth decade of life. The lesions are asymptomatic or mildly pruritic. Skin changes are dark brown or slate grey macules or papules with, in most cases, a diffuse pigmentation pattern. They most commonly affect the face, neck and upper limbs. Cause is unknown but various factors (e.g. viral infections and certain topical agents including mustard oil and henna hair dyes) can trigger the disease.\nConcepts: anti-GITR MoAb BMS-986156 (Anti-GITR Monoclonal Antibody)\tregulation of protein deubiquitination (regulation of protein modification by small protein conjugation or removal)\tAnalyses, Semen Quality (Body fluid analysis)\tPost-inflamm hyperpigt in LP (Disease or Syndrome)\tMoebius congenital oculofacial paralysis (Disorder of extremity)", + "output": "Post-inflamm hyperpigt in LP (Disease or Syndrome)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of potassium ions.\nConcepts: Forensic Psychology (Biomedical Occupation or Discipline)\tregulation of macrophage apoptotic process (Cell Function)\tcellular response to potassium starvation (Cell Function)\tCYCLAZOCINE (Azocines)\tDocumentVersion.versionNumberText (Intellectual Product)", + "output": "cellular response to potassium starvation (Cell Function)" + }, + { + "input": "Definition: Neoplasm by body site described as a malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.\nConcepts: Nephrotic syndrome with lesion of membranous glomerulonephritis (Disease or Syndrome)\tSulfadiazine silver (Anti-Bacterial Agents)\tGrade 3 Adrenal insufficiency (Adrenal Insufficiency, CTCAE)\tnegative aerotaxis (negative energy taxis)\tMyeloma-Multiples (Plasmacytoma)", + "output": "Myeloma-Multiples (Plasmacytoma)" + }, + { + "input": "Definition: Functional Concept described as an indication that a data element corresponding to a microbiology susceptibility assessment has been derived from one or more data elements.\nConcepts: Uterine Monitorings (Obstetric procedure)\tANALYZER, GAS, NITROGEN, GASEOUS-PHASE (Analyzers, Laboratory, Breath)\tFAC006-I Am Losing Weight (FACT-BL Version 4 Questionnaire Question)\tMicrobiology Susceptibility Derived Flag (Functional Concept)\tAdult Attitudes (Attitude)", + "output": "Microbiology Susceptibility Derived Flag (Functional Concept)" + }, + { + "input": "Definition: something described as a fusion gene (~2.4 kb) that results from a chromosomal translocation t(2;3)(p23;q21) which fuses a third of the 5' portion of the TFG gene to the last 10 exons of the ALK gene. This rearrangement is associated with anaplastic large cell lymphoma.\nConcepts: economic competition (Occupational Activity)\tMauthner's neuron (Cell)\tDeleterious LyF-1 Gene Mutation (IKZF1 Gene Mutation)\tTFG/ALK Short Form Fusion Gene (Gene or Genome)\tskin allografts (Allograft surgical material)", + "output": "TFG/ALK Short Form Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: Skin of part of ankle and foot described as the skin covering the foot.\nConcepts: Ocular Adnexal Lymphoma cM1b TNM Finding v8 (Ocular Adnexal Lymphoma Clinical Distant Metastasis TNM Finding v8)\tNEK9 gene (Gene or Genome)\tHMUDG (Hydrolase Gene)\tFoot skin (Skin of part of foot)\tcell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (Molecular Function)", + "output": "Foot skin (Skin of part of foot)" + }, + { + "input": "Definition: MYO ENDO PERICARDIAL & VALVE DISORDERS described as myocardial fibrosis is characterized by dysregulated collagen turnover (increased synthesis predominates over unchanged or decreased degradation) and excessive diffuse collagen accumulation in the interstitial and perivascular spaces as well as by phenotypically transformed fibroblasts, termed myofibroblasts.\nConcepts: OXACREAT (Laboratory Procedure)\tMYOCARDIAL FIBROSIS (HEART: MYOCARDIUM/PERICARDIUM)\tStreptomyces coelicolor subspecies coelicolor (Streptomyces albidoflavus group)\tPROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE, 1 (Gene or Genome)\tIVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification (IVD Test Reagent/Kits, Immunohematology)", + "output": "MYOCARDIAL FIBROSIS (HEART: MYOCARDIUM/PERICARDIUM)" + }, + { + "input": "Definition: something described as a perfluorocarbon blood substitute in trials for the treatment of severe anemia\nConcepts: meiotic chromosome decondensation (chromosome organization involved in meiotic cell cycle)\t2,6-Dithia-1,3,5,7-tetraazaadamantane, 2,2,6,6-tetraoxide (Rodenticides)\tregulation of melanosome organization (Cell Function)\tFluosol-DA (Blood Substitutes)\tFAC016-Get Emotional Support From Family (FACT-L Version 4 Questionnaire Question)", + "output": "Fluosol-DA (Blood Substitutes)" + }, + { + "input": "Definition: negative regulation of tumor necrosis factor superfamily cytokine production described as any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.\nConcepts: Thermotherapy, Transurethral Microwave (Procedure by transurethral approach)\tPROMIS Bank v1.0 - Psychosocial Illness Impact-Pos (Research or Clinical Assessment Tool)\tPolyoxyl 50 Hydrogenated Castor Oil (hydrogenated castor oil)\tnegative regulation of lymphotoxin-alpha production (Organism Function)\tTRP2 mRNA-electroporated autologous langerhans-type dendritic cell vaccine (Dendritic Cell Vaccine)", + "output": "negative regulation of lymphotoxin-alpha production (Organism Function)" + }, + { + "input": "Definition: something described as the maximum amount that can be contained, in the first dimension of size of the equipment. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: GALANIN RECEPTOR 2 (Gene or Genome)\tCinguloparietal transition area (Brodmann area)\tAcute annular outer retinopathy (Acute disease of eye)\tStorageEquipment.dimensionOneCapacity (Dimension One Capacity)\tDBA/2 Mouse (Mice, Inbred Strains)", + "output": "StorageEquipment.dimensionOneCapacity (Dimension One Capacity)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.\nConcepts: mannitol dehydrogenase (cytochrome) activity (oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor)\tcellular response to mechanical stimulus (cellular response to abiotic stimulus)\t1,2,3-trihydroxybenzene:oxygen 1,2-oxidoreductase (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tIrregular epiphysis of the middle phalanx of the 4th finger (Irregular epiphyses of the 4th finger)\tMicrosatellite Instability Present (Genomic Instability)", + "output": "cellular response to mechanical stimulus (cellular response to abiotic stimulus)" + }, + { + "input": "Definition: something described as airway Questionnaire 20 (AQ20) Do you worry a lot about your chest trouble?\nConcepts: planar cell polarity pathway involved in cardiac right atrium morphogenesis (planar cell polarity pathway involved in heart morphogenesis)\tAQ0120 (AQ20 Questionnaire Question)\tCytogenetics, Clinical - Physicians (Professional or Occupational Group)\tjmml (Hematological Disease)\tAgricultural Inoculant (Fungi)", + "output": "AQ0120 (AQ20 Questionnaire Question)" + }, + { + "input": "Definition: Coagulation factor deficiency syndrome described as an autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of factor X activity in the blood.\nConcepts: Hereditary Stuart-Prower deficiency disease (Coagulation factor deficiency syndrome)\tNeurotrophic Receptor Tyrosine Kinase 1 c.1792C>T (NTRK1 Gene Mutation)\tchitosamine metabolic process (amino sugar metabolic process)\tQS-Expanded DRS-PI Caregiver Version TEST (Intellectual Product)\tStage III Lip and Oral Cavity Cancer (Lip and Oral Cavity Cancer by AJCC v8 Stage)", + "output": "Hereditary Stuart-Prower deficiency disease (Coagulation factor deficiency syndrome)" + }, + { + "input": "Definition: Potency Unit described as a dosing measurement based on the suppository unit.\nConcepts: CULTURE MEDIA, VITAMIN ASSAY (Medical Device)\tSyringes, Plunger, Arterial Blood Sampling, Protective, Luer Slip (Medical Device)\tAR (Quantitative Concept)\tY chromosome deletions (Y Chromosome)\tTW2 radius-ulna-short (RUS) bones (Intellectual Product)", + "output": "AR (Quantitative Concept)" + }, + { + "input": "Definition: Urologic Surgical Procedures described as temporary or permanent diversion of the flow of urine through the ureter away from the URINARY BLADDER in the presence of a bladder disease or after cystectomy. There is a variety of techniques: direct anastomosis of ureter and bowel, cutaneous ureterostomy, ileal, jejunal or colon conduit, ureterosigmoidostomy, etc.\nConcepts: Analysis, Sex Determination (Diagnostic Techniques and Procedures)\tImplantable Electrodes (Prostheses and Implants)\turinary diversion procedure (Ureter operation)\tannual reports (organizational document)\tG protein subunit gamma 12 (Heterotrimeric G Protein Subunit Gene)", + "output": "urinary diversion procedure (Ureter operation)" + }, + { + "input": "Definition: something described as the area under the urinary excretion rate curve (AURC) extrapolated to infinity, calculated using the predicted value of the last non-zero excretion rate, divded by the weight.\nConcepts: Glucose Clamp Techniques (Research Activity)\tangiocardioultrasonography (Diagnostic Procedure)\tMethylglyoxal (glyoxal)\tVFQ211 (VFQ25-Self Administered Format Questionnaire Question)\tAURC Infinity Predicted Normalized by Weight (Area Under Urinary Excretion Rate Curve)", + "output": "AURC Infinity Predicted Normalized by Weight (Area Under Urinary Excretion Rate Curve)" + }, + { + "input": "Definition: Hereditary disorder of musculoskeletal system described as a rare genetic neuro-ophthalmological disease with characteristics of progressive weakness of the external eye muscles, resulting in bilateral ptosis and diffuse, symmetric ophthalmoparesis. Additional signs may include generalised skeletal muscle weakness, muscle atrophy, sensory axonal neuropathy, ataxia, cardiomyopathy, and psychiatric symptoms. It is usually more severe than autosomal dominant form.\nConcepts: Autosomal recessive progressive external ophthalmoplegia (Mitochondrial cytopathy)\tThymidine Phosphorylase wt Allele (Gene or Genome)\tPapillomavirus Transforming Protein E6 (Biologically Active Substance)\tHspB1 (Biologically Active Substance)\tPLASMA THROMBOPLASTIN COMPONENT DEFICIENCY (LABORATORY ABNORMALITIES)", + "output": "Autosomal recessive progressive external ophthalmoplegia (Mitochondrial cytopathy)" + }, + { + "input": "Definition: something described as cells from human blood or umbilical cord blood for transplantation or infusion.\nConcepts: Fiber Device (Device Component or Accessory)\tGenome, Plastid (Gene or Genome)\tHuman Peripheral And Cord Blood Cell Product (Blood product)\tLumiliximab (Amino Acid, Peptide, or Protein)\tAcute Kidney Injuries (Injury of kidney)", + "output": "Human Peripheral And Cord Blood Cell Product (Blood product)" + }, + { + "input": "Definition: something described as forms of the element arsenic found in foods.\nConcepts: 17-O-acetylnorajmaline:NADP+ oxidoreductase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tDietary Arsenic (dietary mineral)\tOdontogenic tumour, malignant (Primary malignant neoplasm)\tTIMG0101 (Intellectual Product)\tRespiratory System Findings Reason Not Done (Not-Done Reason)", + "output": "Dietary Arsenic (dietary mineral)" + }, + { + "input": "Definition: something described as pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity. It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion. PID may be either symptomatic or asymptomatic. It may cause infertility and it may raise the risk of ectopic pregnancy. PID is a disease associated with HIV infection.\nConcepts: fermentative hydrogen production (Fermentation)\tRetinoid (Targeted Therapy Agent)\tDiseases, Pelvic Inflammatory (Inflammatory disorder of genitourinary system)\tLYMPHOMA HODGKIN RECURRENT (Neoplastic Process)\t131I-MIBG (Radioisotopes)", + "output": "Diseases, Pelvic Inflammatory (Inflammatory disorder of genitourinary system)" + }, + { + "input": "Definition: something described as this gene is involved in circadian rhythm.\nConcepts: CONGENITAL HYPOTHALAMIC HAMARTOMA SYNDROME (Abnormal hypothalamus morphology)\tpeptidyl-arginine hydroxylation (Molecular Function)\tDifficulty (Finding)\tCryptochrome 2 (Photolyase-Like) Gene (Genes, Regulator)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Cryptococcus neoformans, rRNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Cryptococcus neoformans)", + "output": "Cryptochrome 2 (Photolyase-Like) Gene (Genes, Regulator)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 1, Word 6.\nConcepts: ADNI AVLT - List A Recall 1 Word 6 (Intellectual Product)\tTSCYC1-Being Absent-minded (TSCYC Questionnaire Question)\tRefractory Malignant Lip and Oral Cavity Neoplasm (Neoplastic Process)\tTracheobronchomalacias (Tracheobronchial disorder)\tChronic sphenoidal sinusitis (Chronic sinusitis)", + "output": "ADNI AVLT - List A Recall 1 Word 6 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicide Severity Rating Scale Children's Since Last Visit - Description of active suicidal ideation with specific plan and intent.\nConcepts: Mixed type liposarcoma (Lipomatous neoplasm)\tScroto- (Male external genitalia structure)\tPurkinje myocyte to ventricular cardiac muscle cell communication (Cell Function)\tCholesterol to HDL-Cholesterol Ratio Measurement (Lipids measurement)\tC-SSRS Children's Since Last Visit - Description of Active Suicidal Ideation with Specific Plan and Intent (C-SSRS Children's Since Last Visit Questionnaire Question)", + "output": "C-SSRS Children's Since Last Visit - Description of Active Suicidal Ideation with Specific Plan and Intent (C-SSRS Children's Since Last Visit Questionnaire Question)" + }, + { + "input": "Definition: something described as a cranial malformation with characteristics of facial dysmorphism (proptosis, frontal bossing, midface and zygomatic arches hypoplasia, short nose with anteverted nostrils, microstomia with persistent buccopharyngeal membrane, severe hypoglossia with glossoptosis, severe mandibular hypoplasia and low set ears) associated with laryngeal hypoplasia and craniosynostosis. Other variable features include cleft palate, optic nerve coloboma and choanal stenosis. An autosomal recessive mode of inheritance has been suggested.\nConcepts: MONOPHOSPHORYL LIPID A (Pharmacologic Substance)\tgeneral body state finding asthenia (Asthenic conditions)\tthymidylate nucleotidase activity (Molecular Function)\tPre-Prints as Topics (Publishing)\tHYPOMANDIBULAR FACIOCRANIAL DYSOSTOSIS (Hereditary disorder of musculoskeletal system)", + "output": "HYPOMANDIBULAR FACIOCRANIAL DYSOSTOSIS (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: Physiologic Function described as any process that activates or increases the frequency, rate or extent of epiboly involved in gastrulation with mouth forming second.\nConcepts: First (General Qualifier)\themoprotein metabolism (Protein Metabolism Process)\tpeptidoglycan cross-bridge peptide endopeptidase activity (Molecular Function)\tPlaster Dose Form (Biomedical or Dental Material)\tup regulation of epiboly involved in gastrulation with mouth forming second (positive regulation of morphogenesis of an epithelium)", + "output": "up regulation of epiboly involved in gastrulation with mouth forming second (positive regulation of morphogenesis of an epithelium)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of lead (Pb) ions from one side of a membrane to the other.\nConcepts: positive regulation of molecular function in other organism (negative regulation of molecular function)\tEmployment (employment/unemployment)\tHuman MOAB LICO 28a32 (Monoclonal Antibodies)\tup regulation of short-day photoperiodism, flowering (Physiologic Function)\tlead ion transmembrane transporter activity (inorganic molecular entity transmembrane transporter activity)", + "output": "lead ion transmembrane transporter activity (inorganic molecular entity transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a site of slightly thickened desmosomes in the stratum spinosum of the epidermis.\nConcepts: Alcohol Breath Analyzers (General hospital device)\tDeltaNp63 Alpha (Biologically Active Substance)\tNode of Bizzozero (Body Location or Region)\tNon-Medicare Approved Hospital Transfusion Service (Clinical Services)\tMuscular Cramps (Neuromuscular Manifestations)", + "output": "Node of Bizzozero (Body Location or Region)" + }, + { + "input": "Definition: Food described as infant formula with nutrient composition designed to meet standard infant nutritional needs and meet guidelines for organic labeling.\nConcepts: Nursery School (Organization)\tembryonic heart tube morphogenesis (Organism Function)\tHematopoiesis, Clonal (Finding)\tStandard infant organic formula (Standard infant formula)\tStage III Lip and Oral Cavity Cancer AJCC v7 (Neoplastic Process)", + "output": "Standard infant organic formula (Standard infant formula)" + }, + { + "input": "Definition: tumor necrosis factor family gene described as this gene is involved in T-cell regulation.\nConcepts: tax-transcriptionally activated glycoprotein 1, 34kD (tumor necrosis factor family gene)\tCentisecond (Quantitative Concept)\talditol biosynthesis (Molecular Function)\tRadionuclide Scanning and Imaging (Radionuclide Imaging)\thistone lysine N-acetyltransferase activity (H3 histone acetyltransferase activity)", + "output": "tax-transcriptionally activated glycoprotein 1, 34kD (tumor necrosis factor family gene)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: indole-3-acetyl-beta-4-D-glucose + H2O <=> H+ + indole-3-acetate + beta-D-glucose.\nConcepts: Neurogenic Locus Notch Homolog Protein 1 Ser2467GlyfsTer11 (NOTCH1 NP 060087.3:p.S2467 Frameshift)\tindole-3-acetyl-beta-4-D-glucose hydrolase activity (Molecular Function)\t1 (Finding)\tAlzheimer Disease Gene Panel Reagents (IVD Panels, Human Genetics, Neurodegenerative Disorder, Dementia)\tRisk for shock (Finding)", + "output": "indole-3-acetyl-beta-4-D-glucose hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Transferase described as an enzyme that catalyzes the transfer of glucose from ADPglucose to glucose-containing polysaccharides in 1,4-alpha-linkages. EC 2.4.1.21.\nConcepts: C4ST-1 (Enzyme)\tVulvar Liposarcoma (Sarcoma of vulva)\tStarch (bacterial glycogen) synthase (Transferase)\t6\u03b1-Methyl-4-pregnene-3,20-dion-17\u03b1-ol acetate (Progestins)\tchromosome passenger complex localization to central spindle (Cell Function)", + "output": "Starch (bacterial glycogen) synthase (Transferase)" + }, + { + "input": "Definition: something described as impaired or altered function of the foot.\nConcepts: Tyrosine Kinase DDR (Amino Acid, Peptide, or Protein)\tEffervescent powder and powder for oral suspension (Combined Dosage Form)\tml/h (Quantitative Concept)\tBody Surface Area Formula for Cats (Quantitative Concept)\tFoot Somatic Dysfunction (Finding)", + "output": "Foot Somatic Dysfunction (Finding)" + }, + { + "input": "Definition: Peripheral Nerves described as a major nerve of the upper extremity. The fibers of the musculocutaneous nerve originate in the lower cervical spinal cord (usually C5 to C7), travel via the lateral cord of the brachial plexus, and supply sensory and motor innervation to the upper arm, elbow, and forearm.\nConcepts: positive regulation of blood vessel remodeling (regulation of blood vessel remodeling)\tAcinar Cell Cystadenocarcinoma (Carcinoma)\tDAD01-Decide to Brush Teeth Dentures (Intellectual Product)\tup-regulation of neuron apoptosis (Cell Function)\tStructure of musculocutaneous nerve (Brachial plexus structure)", + "output": "Structure of musculocutaneous nerve (Brachial plexus structure)" + }, + { + "input": "Definition: something described as this gene plays a role in T-cell homing.\nConcepts: TSCYC1-Acting Like He/She Was in Trance (Intellectual Product)\tOlfactory nerve structure (Body Part, Organ, or Organ Component)\tGPR15 Gene (G Protein-Coupled Receptor Genes)\tGrade 3 Premature Delivery, CTCAE (Premature Delivery, CTCAE)\tEpileptic fits NOS (Korean Standard Classification of Disease Version 5)", + "output": "GPR15 Gene (G Protein-Coupled Receptor Genes)" + }, + { + "input": "Definition: something described as non-native organisms brought into a region, habitat, or ECOSYSTEM by human activity.\nConcepts: diverticulum unci (Body Part, Organ, or Organ Component)\tAlien Specy (Population Group)\tPULDIABP (Pulmonary function tests)\tmammectomy (Operations on the integumentary system)\td.g/mL/(mg/g) (Quantitative Concept)", + "output": "Alien Specy (Population Group)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the mediation of acute phase inflammatory responses.\nConcepts: Siglec (Receptor)\tStage IIIB Primary Peritoneal Cancer AJCC v7 (Stage III Primary Peritoneal Cancer AJCC v7)\tresponse to biphenyl (Cell Function)\tEpiglottis (EPIGLOTTIS AND LARYNX)\tInterleukin 1, Beta Gene (Gene or Genome)", + "output": "Interleukin 1, Beta Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as writings originating from the 15th century A.D. to the present\nConcepts: Ubiquitin Ligase, SCF (ubiquitin-protein ligase)\tDecompensation, Corneal (Corneal Diseases)\tMetastatic Tumor to the Brain Stem (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE NERVOUS SYSTEM AND SPECIAL SENSE ORGANS)\tHeterotheca (North American clade)\tLIT MODERN (Intellectual Product)", + "output": "LIT MODERN (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.\nConcepts: CYTOCHROMES A 01 (Biologically Active Substance)\tgrade 1 follicular lymphoma (Malignant lymphoma, follicular AND/OR nodular)\tHODY (Temporal Concept)\tup-regulation of meiotic cell cycle process involved in oocyte maturation (regulation of meiotic cell cycle process involved in oocyte maturation)\tHBZ (Globin Gene)", + "output": "up-regulation of meiotic cell cycle process involved in oocyte maturation (regulation of meiotic cell cycle process involved in oocyte maturation)" + }, + { + "input": "Definition: Mucosal findings abnormal described as an acute or chronic infectious process affecting a mucosal surface.\nConcepts: infection mucosa (Infections NEC)\tmeso-Tetramethoxy-4,4'-(2,3-dimethyltetramethylene)dipyrocatechol (Organic Chemical)\t(+)-delta-cadinene-8-hydroxylase activity (Molecular Function)\tRNase D activity (exoribonuclease activity, producing 5'-phosphomonoesters)\tCell Growth Regulation (regulation of growth)", + "output": "infection mucosa (Infections NEC)" + }, + { + "input": "Definition: something described as pediatric Functional Assessment of Chronic Illness Therapy-Fatigue - I had trouble finishing things because I was too tired.\nConcepts: PODCI Pediatric Parent-Reported Version - Competitive Sports Limited by: Instruction (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tFAC099-Trouble Finishing Things (Peds-FACIT-F Questionnaire Question)\tKhaini (Organic Chemical)\tTilia vulgaris (Plant)\tconversion of methionyl-tRNA to N-formyl-methionyl-tRNA (Genetic Function)", + "output": "FAC099-Trouble Finishing Things (Peds-FACIT-F Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as the sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies.\nConcepts: Trunk, NOS (Topographic Regions and Cellular Structure)\tthor.osseous mnplxn ea.mnplx (Therapeutic or Preventive Procedure)\tMole/second (Moles per unit time)\tphosphorylated protein binding (Protein Binding)\tAllopurinol Sodium (Chemical categorised functionally)", + "output": "Allopurinol Sodium (Chemical categorised functionally)" + }, + { + "input": "Definition: Spatulas, Surgical, Eye described as spatulas designed to manipulate and/or dissect eye tissue during the surgical formation of a communication between the anterior chamber of the eye and the suprachoroidal space (i.e., cyclodialysis) performed during surgical procedures for treatment of glaucoma. These devices typically consist of a metallic (e.g., stainless steel) handheld instrument with a straight or curved very thin, flat, blunt distal tip. Some glaucoma surgical eye spatulas are double-ended with a spatula on each end of the handle. Surgical eye spatulas for glaucoma are used in cyclodialysis ophthalmic surgical procedures.\nConcepts: Scotoma (Finding)\teukaryotic initiation factor eIF2 binding (translation initiation factor binding)\tWorkstations, Computer Aided Design/Manufacturing, Orthopedic, Spinal Orthosis/Prosthesis/Seat Cushion (Workstations, Computer-Aided Design/Manufacturing, Orthopedic)\tThiamin supplement therapy (vitamin therapy)\tEye Surgery Spatulas, Glaucoma (Medical Device)", + "output": "Eye Surgery Spatulas, Glaucoma (Medical Device)" + }, + { + "input": "Definition: Environmental Effect of Humans described as a treatment process that uses naturally occurring microorganisms to degrade hazardous substances into less toxic or nontoxic substances.\nConcepts: Central Nervous System Sarcoma (Neoplastic Process)\tmTOR Protein (Protein Kinases)\tBioremediation (Environmental Effect of Humans)\tDiglyceride Kinase (Phosphotransferases)\tMucosal Melanoma of the Head and Neck pN0 TNM Finding v7 (Finding)", + "output": "Bioremediation (Environmental Effect of Humans)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene = 1,2-dihydroxy-8-carboxynaphthalene + 2 H+ + 2 e-.\nConcepts: NC-318 (Monoclonal Antibodies)\tcis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity (Molecular Function)\tHistone-Lysine N-Methyltransferase MLL4 (Enzyme)\tTelencephalon medium (Body Part, Organ, or Organ Component)\tashi 15min (Oriental massage)", + "output": "cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: FACIT-Dyspnea 10 Item Short Form Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part II Functional Limitation. Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Walking 50 steps/paces on flat ground at a normal speed without stopping.\nConcepts: Clinodactyly of the little finger (Clinodactyly of fingers)\tFACIT-Dyspnea 10 Item Short Form - Part II: Walk 50 Steps (Intellectual Product)\tregulation of dorsal/ventral axon guidance (regulation of axon guidance)\tcooking (Food Handling)\tPreauricular tags (Skin tag)", + "output": "FACIT-Dyspnea 10 Item Short Form - Part II: Walk 50 Steps (Intellectual Product)" + }, + { + "input": "Definition: something described as abnormally increased levels of tryptophan in cerebrospinal fluid.\nConcepts: UPD23C1 (MDS-UPDRS Questionnaire Question)\tVaccines, Typhoid (Vaccines)\tprotein arginine phosphatase activity (protein phosphatase activity)\tIncreased CSF tryptophan concentration (Abnormal CSF tryptophan concentration)\tInitiate (Action)", + "output": "Increased CSF tryptophan concentration (Abnormal CSF tryptophan concentration)" + }, + { + "input": "Definition: something described as human UGT1A9 wild-type allele is located in the vicinity of 2q37 and is approximately 101 kb in length. This allele, which encodes UDP-glucuronosyltransferase 1-9 protein, plays a role in the detoxification of phenolic compounds.\nConcepts: UGT1-9 (Gene or Genome)\tregulation of AMPA receptor activity (regulation of glutamate receptor signaling pathway)\tFocal aware pedal automatism seizure (Disease or Syndrome)\tAbsolute Neutrophil (Laboratory Procedure)\tEndoscopic retrograde cholangiopancreatography -RETIRED- (Liver and/or pancreas and/or biliary tract contrast procedure)", + "output": "UGT1-9 (Gene or Genome)" + }, + { + "input": "Definition: something described as a chromosome band present on 17q\nConcepts: protein localisation in lateral cortical node (protein localization to cell cortex)\tricefish (Class osteichthyes - bony fish)\tplantar fibromatosis (MUSCLE SOFT, TISSUE)\t17q11-q21.3 (Cell Component)\tFowler position (Supine Position)", + "output": "17q11-q21.3 (Cell Component)" + }, + { + "input": "Definition: something described as a reproductive behavior in which a parent cares for and rears offspring.\nConcepts: body space (Anatomic structures)\tAromatic hydrocarbon (Aromatic Compounds)\tparental behavior (Individual Behavior)\tSiblings (status by family relationship)\tflavone synthase activity (Molecular Function)", + "output": "parental behavior (Individual Behavior)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective score of 2 on a scale that ranges from 0: As Bad As It Can Be to 10: As Good As It Can Be.\nConcepts: mesonephric macula densa development (macula densa development)\tContinuous Phase (Substance)\tFeeling Intensity Score 2 (Clinical or Research Assessment Answer)\tdeinstitutionalization (Mental health program)\tFocal impaired awareness hyperkinetic seizure (Focal hyperkinetic seizure)", + "output": "Feeling Intensity Score 2 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as a non-metastasizing neoplasm that arises from the renal pelvis. Urothelial papilloma is a representative example.\nConcepts: Benign Tumor of Renal Pelvis (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE GENITOURINARY SYSTEM)\tFluorosis dental (Intrinsic staining of tooth)\tglutamate breakdown to aspartate (aspartate metabolic process)\tIVD Test Reagent/Kits, Immunoassay, Endocrine Hormone, Insulin-Like Growth Factor I (IVD Test Reagent/Kits, Immunoassay, Endocrine Hormone)\tAPBA1 (Amino Acid, Peptide, or Protein)", + "output": "Benign Tumor of Renal Pelvis (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE GENITOURINARY SYSTEM)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable traditional Chinese medicine (TCM) composed of a granule containing an aqueous extract of Trametes robiniophila murr (Huaier), a mushroom found on hardwood tree trunks, with potential antineoplastic and anti-angiogenic activities. Although the exact mechanism of action through which Huaier exerts its effects is largely unknown, upon administration, this agent induces cell cycle arrest and apoptosis, and inhibits proliferation and migration of susceptible cancer cells through the modulation of various signal transduction pathways involved in carcinogenesis and angiogenesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125001\" active clinical trials using this agent.\nConcepts: Ophthalmic Ointment (Ointments)\tHuaier extract granule (Antineoplastic Agents)\thistone H2A-K119 monoubiquitination (Molecular Function)\tIVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Early Epileptic, Comprehensive, Del/Dup (Medical Device)\tHypothalamic hypometabolism in FDG PET (Finding)", + "output": "Huaier extract granule (Antineoplastic Agents)" + }, + { + "input": "Definition: Oncogene Deregulation described as a molecular genetic abnormality indicating the presence of multiple copies of the MYC gene.\nConcepts: PARATHION (Acetylcholinesterase Inhibitors)\tCentral Nervous System Radiation Injury (Injury or Poisoning)\tGenetic Testing Molecular Assay Laboratory Analysis Software (Software, Laboratory Analysis, Molecular Assay)\tFluids, Intracellular (Intracellular Space)\tMYC Amplification (Gene Amplification Abnormality)", + "output": "MYC Amplification (Gene Amplification Abnormality)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual is or was able to put their thoughts together.\nConcepts: pN1mi Cancer of the Breast v6 (Breast Cancer pN1 TNM Finding v6)\tAble to Put Thoughts Together (Intellectual Product)\t(R)-sulfopropanediol 2-dehydrogenase activity (Molecular Function)\tGDS01-Memory Problems (GDS Questionnaire Question)\tregulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signaling (Cell Function)", + "output": "Able to Put Thoughts Together (Intellectual Product)" + }, + { + "input": "Definition: something described as physical location of ETS1_Gene\nConcepts: 11: 127897371-127833873 (Chromosome 11 Physical Location)\tTermgroup (Terminology Entity)\tComplex endometrial hyperplasia without atypia (Pathologic Function)\tDescription of Epochs of O2 Desaturation Less than 92% Greater than 5 Minutes Prior to Organ Excision (CPTAC Questions)\t6MWT - Distance at 6 Minutes (6MWT Functional Test Question)", + "output": "11: 127897371-127833873 (Chromosome 11 Physical Location)" + }, + { + "input": "Definition: Analgesics described as a combination preparation of methenamine, methylene blue, benzoic acid, phenyl salicylate, atropine sulfate, and hyoscyamine sulfate, with anti-inflammatory, antispasmodic and analgesic properties. Methenamine hydrolyzes into formaldehyde in acidic urine, thereby providing mild antiseptic effect. Methylene blue also exerts mild antiseptic activity and may inhibit bacterial proliferation. Benzoic acid exerts mild antibacterial and antifungal activities and helps maintain an acidic pH in the urine necessary for the degradation of methenamine to formaldehyde. Phenyl salicylate exerts mild analgesic, antipyretic and anti-inflammatory actions. Atropine sulfate and hyoscyamine sulfate are antimuscarinic agents that prevent smooth muscle spasms by antagonizing actions of acetylcholine. Urised is used for the relief of symptoms associated with urinary tract infections or diagnostic procedures.\nConcepts: Interruption of Chemotherapy (Therapeutic or Preventive Procedure)\tgastrin-induced gastric acid secretion (Organ or Tissue Function)\tregulation of axon extension involved in regeneration (Biologic Function)\tAtropine/Hyoscyamine/Methenamine/Methylene Blue/Phenyl Salicylate/Benzoic Acid (Analgesics)\tCytoplasmic (Erythrocytes)", + "output": "Atropine/Hyoscyamine/Methenamine/Methylene Blue/Phenyl Salicylate/Benzoic Acid (Analgesics)" + }, + { + "input": "Definition: Oral Manifestations described as bleeding from the blood vessels of the mouth, which may occur as a result of injuries to the mouth, accidents in oral surgery, or diseases of the gums.\nConcepts: haemorrhage oral (Gastrointestinal Hemorrhage)\tIVD Test Reagent/Kits, Immunoassay, Control, Therapeutic Drug (Medical Device)\tprotein-cysteine S-oleoyltransferase activity (protein-cysteine S-acyltransferase activity)\tUrea Cycle Disorder (Amino Acid Metabolism, Inborn Errors)\tsyndrome tolosa-hunt (Fifth cranial nerve finding)", + "output": "haemorrhage oral (Gastrointestinal Hemorrhage)" + }, + { + "input": "Definition: something described as physical location of BCAR3_Gene\nConcepts: EHF Protein (TRANSCRIPTION FACTOR)\t1: 93859223-93739372 (Chromosome 1 Physical Location)\tFanconi Anemia Group D2 Nuclear Foci Absent (Normal Laboratory Test Result)\tVaginal Cancer Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)\tadenosylcobinamide kinase (GTP-specific) activity (adenosylcobinamide kinase activity)", + "output": "1: 93859223-93739372 (Chromosome 1 Physical Location)" + }, + { + "input": "Definition: Stretch Receptors described as the Muscle Spindle is composed of intrafusal fibers that are located within and run parallel to the extrafusal fibers of skeletal muscle. When the extrafusal fibers are stretched, the intrafusal fibers of the spindle stretch as well. When stretching occurs, the sensory neuron from the muscle spindle signals the motor neurons located within the ventral horn of the spinal cord. This signal causes the motor neurons to fire, resulting in contraction of the muscle. This reflex arc provides negative feedback. The muscular contraction induced by the stretching works against or negates further muscle stretch. This mechanism helps to maintain proper muscle tension or tone. Although the muscle spindle helps to maintain proper muscle tension, unlike the Golgi tendon organ, it is not an indicator of muscle tension, but rather of muscle length.\nConcepts: Midazolam-containing product (Benzodiazepine [EPC])\tphosphoglucomutase (glucose-cofactor) activity (Molecular Function)\tStretch Receptor, Muscle (Muscle part)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report - Back Feels Stiff (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tquercetin 3-O-methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)", + "output": "Stretch Receptor, Muscle (Muscle part)" + }, + { + "input": "Definition: something described as documentation given to a study subject, which is not otherwise classified.\nConcepts: Aplasia/Hypoplasia of the iris (Aplasia/Hypoplasia affecting the anterior segment of the eye)\tCHROMATOGRAPHIC SEPARATION/ZIMMERMAN, 17-KETOSTEROIDS (Medical Device)\tCircumflex (Anatomy Qualifier)\tHistone Deacetylation (histone modification)\tOther Subject Forms (Intellectual Product)", + "output": "Other Subject Forms (Intellectual Product)" + }, + { + "input": "Definition: Amino acids measurement described as a measurement of the arginine in a biological specimen.\nConcepts: One Active Hour (Finding)\tArginine Test (Laboratory Procedure)\tregulation of protein localisation to phagocytic vesicle (Cell Function)\tGoeldi's Monkey (Callitrichinae)\tvvDD-CDSR (Immunologic Factor)", + "output": "Arginine Test (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as a sequence of digits or characters used to identify a particular telephone, fax, or email of the authoring device. EXAMPLE(S): OTHER NAME(S): NOTE(S): The set of digits that serves as the address for a telephone device. Included in the phone number are country, city, and area codes needed to uniquely address the telephone. A URL or e-mail would be similarly described.\nConcepts: Optic Papillas (Anatomical feature)\tOlfactory receptor cell (olfactory nerve system)\tSensory Art Therapies (Therapeutic or Preventive Procedure)\tAuthoringDevice.telecomAddress (Intellectual Product)\tBleomycin/Dacarbazine/Doxorubicin/Prednisone/Vincristine (Therapeutic or Preventive Procedure)", + "output": "AuthoringDevice.telecomAddress (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the regulation of both glucocorticoid receptor gene expression and Rac GTPase-activating activity.\nConcepts: superoxide release (Molecular Function)\t1: 150161148-150159257 (Spatial Concept)\tRho GTPase activating protein 35 (Gene or Genome)\tsiderosis (Poisoning by iron)\tMitochondrial Myopathy with Sensorimotor Polyneuropathy, Ophthalmoplegia, and Pseudo-Obstruction (Chronic digestive system disorder)", + "output": "Rho GTPase activating protein 35 (Gene or Genome)" + }, + { + "input": "Definition: Clinical Enzyme Tests described as the determination of the amount of beta glucuronidase present in a sample.\nConcepts: Beta Glucuronidase Measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tcalcium oxalates (Oxalates)\tAntisickling agents (Pharmacologic Substance)\tprosopis (Plant)\tSDTM Version 1.3 (Study Data Tabulation Model Version)", + "output": "Beta Glucuronidase Measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: Benzodiazepines described as a synthetic derivative of thienobenzodiazepine with antipsychotic, antinausea, and antiemetic activities. As a selective monoaminergic antagonist, olanzapine binds with high affinity binding to the following receptors: serotoninergic, dopaminergic, muscarinic M1-5, histamine H1, and alpha-1-adrenergic receptors; it binds weakly to gamma-aminobutyric acid type A, benzodiazepine, and beta-adrenergic receptors. The antinausea and antiemetic effects of this agent appear to be due to the blockade of 5-HT2 and 5-HT3 receptors for serotonin. Although its exact mechanism of action in schizophrenia is unknown, it has been proposed that olanzapine's antipsychotic activity is mediated through antagonism to dopamine D2 receptors with rapid ligand-receptor dissociation kinetics that help to minimize extrapyramidal symptoms (EPS). Olanzapine may also stimulate appetite. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47639\" active clinical trials using this agent.\nConcepts: Microsatellitosis Absent (Physical shape)\tBartonelloses (Disease or Syndrome)\tPTGS1 Gene (Signaling Pathway Gene)\tHypopharyngeal Cancer TNM Finding v6 (Finding)\tOlanzapine product (Drug allergens)", + "output": "Olanzapine product (Drug allergens)" + }, + { + "input": "Definition: Urinary tract fluids and spaces described as excretion in liquid state processed by the kidney.\nConcepts: macropexophagy (selective autophagy)\tTrogopterorum / wu ling zhi (Plant)\tPubic Symphysis Diastasis (dislocation of the lumbar spine and pelvis)\tSARCOIDOSIS (Infectious and Communicable Diseases of Undetermined Etiology)\tUrinary System, Urine (URINARY TRACT: GENERAL TERMS)", + "output": "Urinary System, Urine (URINARY TRACT: GENERAL TERMS)" + }, + { + "input": "Definition: Group ID described as a character or string that represents an adverse event group.\nConcepts: HL20 (DNAH9 gene)\tINFECT ENCEPH (Infective disorder of head)\tinduction by virus of host mRNA catabolic process (modulation by virus of host cellular process)\tPolo-Box Domain (Protein Domain)\tAdverse Event Group Identifier (Intellectual Product)", + "output": "Adverse Event Group Identifier (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human Phosphoinositol Kinase Family Genes encode Phosphoinositol Kinases, enzymes that phosphorylate at various positions the inositol group in membrane-bound phosphatidylinositol, often in response to extracellular signals through G-Protein Coupled Receptors or Receptor Tyrosine Kinases. The resultant phosphoinositides act as selective membrane docking sites for signal transduction proteins with diverse PH domains. Phosphorylated inositols are released as second messengers by enzymatic cleavage of the phosphoinositides.\nConcepts: Phosphoinositol Kinase Family Gene (Kinase Family Gene)\tNCCN-FACT-FPSI 17 Version 2 - I Have Trouble Moving My Bowels (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)\tocclusion; retina, central retinal artery (Disorder of soft tissue of head)\tSkin biopsy, subcutaneous RA nodule (Finding)\tCivil rights (Human Rights)", + "output": "Phosphoinositol Kinase Family Gene (Kinase Family Gene)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter L described as fang feng\nConcepts: fang feng (Plant)\tDoes your health now limit you in bending, kneeling, or stooping (Intellectual Product)\ticodextrin solution (Organic Chemical)\tGrade 1 Allergic Reaction, CTCAE (Allergic Reaction, CTCAE)\tPlant Tissue, Cells (Biospecimen)", + "output": "fang feng (Plant)" + }, + { + "input": "Definition: Cancer Etiology described as investigations into the relationship between immune function and cancer. Immunodeficient individuals are less able to mount an attack on cancerous cells.\nConcepts: UPD2105 (MDS-UPDRS Questionnaire Question)\tEthics Committees (Ethics)\tbombesin receptor binding (neuropeptide receptor binding)\tTPR (Carrier Proteins)\tImmunodeficiency and Cancer (Cancer Etiology)", + "output": "Immunodeficiency and Cancer (Cancer Etiology)" + }, + { + "input": "Definition: Flexion contracture of the 2nd finger described as chronic loss of joint motion of the proximal interphalangeal joint of the 2nd finger due to structural changes in non-bony tissue.\nConcepts: down-regulation of transmembrane iron ion transport (Cell Function)\tContracture of the proximal interphalangeal joint of the 2nd finger (Anatomical Abnormality)\tCintirorgon (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tglial cell migration in lateral line nerve (glial cell migration)\tAntigens, House Dust Mites (Amino Acid, Peptide, or Protein)", + "output": "Contracture of the proximal interphalangeal joint of the 2nd finger (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as this gene is involved in the mediation of development in the nervous system.\nConcepts: Rubia tinctorum preparation (Homeopathic remedies letter R)\tONCOGENE EPH (Gene or Genome)\tCommunication Skills (Research or Clinical Assessment Tool)\tOropharyngeal Pain, CTCAE (Finding)\tConcurrent Reviews (Utilization Review)", + "output": "ONCOGENE EPH (Gene or Genome)" + }, + { + "input": "Definition: Organic Chemical described as a cytotoxic sulfhydryl reagent that inhibits several subcellular metabolic systems and is used as a tool in cellular physiology.\nConcepts: Cellular fibroma (Fibromatous neoplasm of borderline malignancy)\tPLASMA, FIBRINOGEN CONTROL (Indicator, Reagent, or Diagnostic Aid)\tDERMATOLEUKODYSTROPHY (Hereditary disorder of the integument)\tregulation of microRNA metabolic process (Genetic Function)\tp-Chloromercuriphenylsulphonate (Phenylmercury Compounds)", + "output": "p-Chloromercuriphenylsulphonate (Phenylmercury Compounds)" + }, + { + "input": "Definition: Body Substance described as fluid withdrawn from a lump, often a cyst, or a nipple.\nConcepts: Gastric Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Gastric Cancer Pathologic TNM Finding v6)\tAcanthoma, Degos (Hyperplasia)\tArea 35 of Brodmann (Brodmann area)\t7-[beta-D-apiofuranosyl-(1->6)-beta-D-glucopyranosyloxy]isoflavonoid beta-D-apiofuranosyl-(1->6)-D-glucohydrolase activity (Molecular Function)\tAsp (Specimen)", + "output": "Asp (Specimen)" + }, + { + "input": "Definition: Common nursing interventions described as managing, monitoring and/or caring for a patient while he or she is undergoing chemotherapy.\nConcepts: chemotherapy care (Procedure with a procedure focus)\tSunday and/or holiday care narrative required (Extended services with or without ICD diagnosis)\t6: 152220800-152516520 (Spatial Concept)\tPiperidines (Organic Chemical)\tSeverity of Chief Complaint (Qualitative Concept)", + "output": "chemotherapy care (Procedure with a procedure focus)" + }, + { + "input": "Definition: Congenital Abnormality described as concomitant PANCREATICOBILIARY MALJUNCTION and local dilatation of the extrahepatic bile duct.\nConcepts: Endometrioid Stromal Sarcoma of the Vagina (Neoplastic Process)\tInvasive Lobular Breast Carcinoma, Solid Variant (Invasive Lobular Breast Carcinoma)\tCongenital Biliary Dilatations (Congenital Abnormality)\tresponse to UV (Biologic Function)\tintracranial pressures (Cerebrospinal Fluid Pressure)", + "output": "Congenital Biliary Dilatations (Congenital Abnormality)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as inserting oil and/or instructing a client in the insertion of oil into his or her colon to restore individual constitutional balance and health. Service is billed in 15-minute increments.\nConcepts: ADNI AVLT - List A Recall 3 Word 1 (ADNI-AVLT Questionnaire Question)\tAnuvasana basti insertion and/or instruction each 15 minutes (Medicine, Ayurvedic)\tLeft coronary arterial branch (Coronary artery)\tAt Times Forget to Take Prescription Medication (Intellectual Product)\tAKR1B1 (Amino Acid, Peptide, or Protein)", + "output": "Anuvasana basti insertion and/or instruction each 15 minutes (Medicine, Ayurvedic)" + }, + { + "input": "Definition: pigment catabolic process described as the chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.\nConcepts: Four to Six Active Hours (Finding)\theme catabolism (Molecular Function)\tgenital (Body part)\tMapatumumab (Pharmacologic Substance)\tEhrlichia ruminantium (Cowdry 1925) Dumler et al. 2001 (Cowdria sp)", + "output": "heme catabolism (Molecular Function)" + }, + { + "input": "Definition: Organic Carcinogen described as a white crystalline solid, both naturally occurring and synthetic, that is soluble in water, ammonium thiocyanate solution and ethanol. In the past, it was used as a photographic toning agent, a component of hair preparations and a dry cleaning agent. Currently, it is only used in animal glue liquefiers and silver tarnish removers. When heated to decomposition, thiourea emits toxic fumes of nitrogen oxides and sulfur oxides. Long-term exposure of humans to thiourea may cause bone marrow damage, resulting in reduced levels of red blood cells, white blood cells and/or platelets. It is reasonably anticipated to be a human carcinogen.\nConcepts: Simulators, Training, Endovascular Procedure (Manufactured Object)\tFreeze-dried Black Raspberry Bioadhesive Gel (Chemopreventive Agent)\tProduct containing thiourea (Nitrogen and nitrogen compound)\tSEND DART IG v1.0 (Version)\tBMP signaling pathway involved in Malpighian tubule cell chemotaxis (Molecular Function)", + "output": "Product containing thiourea (Nitrogen and nitrogen compound)" + }, + { + "input": "Definition: something described as a multisubunit complex that catalyzes the acetylation of histones H4 and H2A.\nConcepts: inhibition of DNA replication initiation involved in mitotic cell cycle DNA replication (regulation of mitotic DNA replication initiation)\tPOU2F1 (Gene or Genome)\tidronoxil suppository NOX66 (Antineoplastic Enzyme Inhibitor)\tcatheter device (C Codes - CMS Hospital Outpatient System)\tH4/H2A histone acetyltransferase complex location (H4 histone acetyltransferase complex)", + "output": "H4/H2A histone acetyltransferase complex location (H4 histone acetyltransferase complex)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as the mesylate salt of rivoceranib, an orally bioavailable, small-molecule receptor tyrosine kinase inhibitor with potential antiangiogenic and antineoplastic activities. Rivoceranib selectively binds to and inhibits vascular endothelial growth factor receptor 2, which may inhibit VEGF-stimulated endothelial cell migration and proliferation and decrease tumor microvessel density. In addition, this agent mildly inhibits c-Kit and c-SRC tyrosine kinases.\nConcepts: APATINIB (Pharmacologic Substance)\tUndifferentiated Vaginal Cancer (Vagina Carcinoma)\tGASTROINTESTINAL SYSTEM (Finding)\tAdenosin (Pharmacologic Substance)\tisophane insulin human (I [Preparations])", + "output": "APATINIB (Pharmacologic Substance)" + }, + { + "input": "Definition: shoot system development described as the regeneration process by which a damaged or lost shoot regrows or re-differentiates. This process may occur via de-differentiation and subsequent reprogramming of somatic cells or activation of existing undifferentiated (meristematic) cells to produce a new shoot meristem and subsequently a new shoot.\nConcepts: Drug Kinetics (Drug Development)\tGenus Octodon (Subfamily Ctenomyinae)\tshoot regeneration (shoot system development)\tRETPT (Intellectual Product)\tAvian Malaria (Malaria)", + "output": "shoot regeneration (shoot system development)" + }, + { + "input": "Definition: something described as applying a cold or ice pack, cap, collar or compress of cold water or alcohol to one or more of a client's body parts or regions. Service is billed in 20-minute increments.\nConcepts: Cold or ice pack each 20 minutes (Therapeutic or Preventive Procedure)\tDistal (Spatial pattern)\tPackage DI Number (Primary Identifier)\tNEISSERIA CONTROLS (Medical Device)\tbacillus pumilus (Bacterium)", + "output": "Cold or ice pack each 20 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as the administration of a drug within the vertebral column. High therapeutic ratio is based on drug delivery directly to central nervous system sites of action.\nConcepts: up regulation by organism of host apoptotic programmed cell death (positive regulation by symbiont of host programmed cell death)\tmultivariate analysis (Correlation Study)\tFAC00103 (FACT-G Version 4 Questionnaire Question)\ttRNA Acylations (Genetic Function)\tIntraspinal route (RouteBySite)", + "output": "Intraspinal route (RouteBySite)" + }, + { + "input": "Definition: Intellectual Product described as the Short Form 36 Health Survey Standard, US Version 2.0 (SF36 v2.0 Standard) Question 9a.\nConcepts: Agents, Cryoprotective (Protective Agents)\tVery Slight Exertion (Intellectual Product)\tPhysical restraints (Procedure categorized by device involved)\tExercise-induced hemolysis (Anemia, Hemolytic)\tSF-36 v2.0 Standard - Question 9a (SF36 v2 0 Standard Questionnaire Question)", + "output": "SF-36 v2.0 Standard - Question 9a (SF36 v2 0 Standard Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as a surgical camera and accessories is a device intended to be used to record operative procedures.\nConcepts: CAMERA, STILL, MICROSURGICAL (Medical Device)\tDRRI1-D: Witnessed Someone Unit Wounded (Intellectual Product)\t1D-myo-inositol-tetrakisphosphate 6-kinase activity (inositol tetrakisphosphate kinase activity)\tthiamine triphosphatase (Acid Anhydride Hydrolases)\tSPRED1 wt Allele (SPRED1 gene)", + "output": "CAMERA, STILL, MICROSURGICAL (Medical Device)" + }, + { + "input": "Definition: Specified cutaneous AND/OR peripheral T cell lymphoma described as a lymph node-based peripheral T-cell lymphoma of T-follicular helper (TFH) cells, with a predominantly follicular growth pattern. It lacks characteristic features of angioimmunoblastic T-cell lymphoma such as proliferation of high endothelial venules or extrafollicular follicular dendritic cells.\nConcepts: Paroxysmal supravent.tachycard (Supraventricular tachycardia)\tTUBE, SHUNT, ENDOLYMPHATIC WITH VALVE (Medical Device)\tElectrosurgical Gas Delivery Units (Medical Device)\tpancreaticojejunostomy, Puestow procedure (Anastomosis of jejunum)\tFollicular Variant Peripheral T-Cell Lymphoma (Neoplastic Process)", + "output": "Follicular Variant Peripheral T-Cell Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: mineral metabolism described as sum of chemical changes that occur within the tissues of an organism consisting of anabolism (biosynthesis) and catabolism of iron; the buildup and breakdown of iron for utilization by the organism.\nConcepts: ELECTROPHORETIC METHOD, CATECHOLAMINES (Medical Device)\tMST1 gene (Gene or Genome)\tiron metabolism (metal metabolism)\tARMET (MANF gene)\tMonoclonal Antibody 95-5-49 (Amino Acid, Peptide, or Protein)", + "output": "iron metabolism (metal metabolism)" + }, + { + "input": "Definition: something described as organ with organ cavity, each instance of which has as its parts some serous membrane and serous cavity . Examples: pleural sac, pericardial sac, tendon sheath, bursa.\nConcepts: MARRIED (Finding of marital or partnership status)\tSerous sac (soft tissue)\tCaryophanaceae Peshkoff 1939 (Firmicutes)\tCongenital Generalized Lipodystrophy Type 1 (Disease or Syndrome)\tExposure Time Point (Temporal Concept)", + "output": "Serous sac (soft tissue)" + }, + { + "input": "Definition: Blasts 10 Percent or More of Bone Marrow Nucleated Cells described as a semi-quantitative microscopic finding indicating that more than 10 percent of the nucleated cells in a bone marrow sample are immature mononuclear cells.\nConcepts: 3-Hydroxy-3-methylglutaric Acid (Organic Chemical)\tI have swelling at my melanoma site (Intellectual Product)\tHydrogenations (Biochemical Phenomena)\tSSX family member 4B (Genes, Regulator)\tBlasts Over 10 Percent of Bone Marrow Nucleated Cells (Finding)", + "output": "Blasts Over 10 Percent of Bone Marrow Nucleated Cells (Finding)" + }, + { + "input": "Definition: Neuroanatomy described as the control of lower brain centers by the cerebrum or cerebral cortex. Compare LATERAL DOMINANCE.\nConcepts: Sulfamethomidine (Long-acting sulfonamides)\tpersicae/tao ren (Plant)\tBalance exerciser (Medical Device)\tADNI AVLT - List A 30 Min Delay Recall Word 2 (Intellectual Product)\tcerebral lateralization (Finding of cerebral dominance)", + "output": "cerebral lateralization (Finding of cerebral dominance)" + }, + { + "input": "Definition: something described as an intraosseous ameloblastoma that arises from the jaw, usually the mandible. It grows slowly, invades locally, and recurs frequently. It presents with swelling of the jaw.\nConcepts: Mucosal Melanoma of the Head and Neck pT3 TNM Finding v8 (Finding)\tIntraosseous Ameloblastoma (Ameloblastoma of jaw)\tAgencies; Community/Behavioral Health (Health Care Related Organization)\tRefractory Epithelioid Malignant Peripheral Nerve Sheath Tumor (Refractory Malignant Peripheral Nerve Sheath Tumor)\trnp (Amino Acid, Peptide, or Protein)", + "output": "Intraosseous Ameloblastoma (Ameloblastoma of jaw)" + }, + { + "input": "Definition: Research Design described as a term allowing the classification of the experiment based on the overall experimental design. EXAMPLE(S): factorial designs, covariance designs, blocking designs, titration study OTHER NAME(S): NOTE(S):\nConcepts: Junctional Adhesion Molecule 3 (Amino Acid, Peptide, or Protein)\tStage IVA Uterine (including Endometrial) Cancer (Neoplastic Process)\tExperiment Design Type (Research Activity)\tIGF-BP4 - Insulin-like growth factor binding protein 4 (Amino Acid, Peptide, or Protein)\tSF-36 v2.0 Acute - Question 9a (SF36 v2 0 Acute Questionnaire Question)", + "output": "Experiment Design Type (Research Activity)" + }, + { + "input": "Definition: Immunologic Factor described as a cancer vaccine consisting of a human epidermal growth factor receptor variant III (EGFRvIIi)-specific peptide conjugated to the non-specific immunomodulator keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. Vaccination with rindopepimut may elicit a cytotoxic T-lymphocyte (CTL) immune response against tumor cells expressing EGFRvIII. EGFRvIII, a functional variant of EGFR that is not expressed in normal tissues, was originally discovered in glioblastoma multiforme (GBM) and has also been found in various other cancers such as breast, ovarian, metastatic prostate, colorectal, and head and neck cancers. EGFRvIII contains an 83 amino acid deletion in its extracellular domain and has been shown to transform NIH/3T3 mouse embryonic fibroblast cells in vitro.\nConcepts: Colorectal Carcinoma pT4b TNM Finding v8 (Colorectal Cancer pT4 TNM Finding v8)\tL-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Cancer Vaccines)\tPHQ0304D (Intellectual Product)\tColour vision deficiencies (Disease or Syndrome)\tRenal Vein or Vena Cava Thrombosis or Other Coagulopathies (Intellectual Product)", + "output": "L-Cysteine, L-leucyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-lysylglycyl-L-asparaginyl-L-tyrosyl-L-valyl-L-valyl-L-threonyl-L-alpha-aspartyl-L-histidyl-S-(1-((4-carboxycyclohexyl)methyl)-2,5-dioxo-3-pyrrolidinyl)-, complex with hemocyanin (Cancer Vaccines)" + }, + { + "input": "Definition: Eicosadienoic Acid described as polyunsaturated fatty acid with 20 carbons and 2 double bonds at the 6th and 9th carbons from the methyl end.\nConcepts: delta11,14-20:2 (fatty acids, omega-6)\tbispecific antibody (Biological Factors)\tInterleukin 12 p70 (Cytokine Measurement)\tbirth controls (Sexuality related problem)\tEltanolone (Pharmacologic Substance)", + "output": "delta11,14-20:2 (fatty acids, omega-6)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual feels their breast is or was swollen.\nConcepts: NPC1L1 gene (Gene or Genome)\tPowder for Beehive Solution Dosage Form (Beehive Dosage Form)\tWhipple's disease (Bacterial intestinal infectious disease)\tDoes your breast appear or feel swollen (Findings-Based Question)\tgamma counter (Medical Device)", + "output": "Does your breast appear or feel swollen (Findings-Based Question)" + }, + { + "input": "Definition: Observation End Day described as the final day of the vital signs assessment.\nConcepts: Contrast Media Injectors, Ultrasound (Medical Device)\tbeta-1,3-mannan 3-mannanohydrolase activity (Molecular Function)\tVSENDY (Observation End Day)\tDAD01-Brush Teeth Take Care of Dentures (DAD Questionnaire Question)\tpositive regulation of store-operated calcium channel activity (Molecular Function)", + "output": "VSENDY (Observation End Day)" + }, + { + "input": "Definition: Organic Chemical described as a group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. They are usually cytotoxic and used as antineoplastic agents.\nConcepts: protein kinase activity (catalytic activity, acting on a protein)\tGrade 1 General disorders and administration site conditions - Other, specify (General Disorders and Administration Site Conditions - Other, Specify, CTCAE)\tthromboembolic disease (cancer-related problem/condition)\tMustards, Phosphoramide (Organophosphorus Compounds)\talditol phosphate metabolic process (phosphate-containing compound metabolic process)", + "output": "Mustards, Phosphoramide (Organophosphorus Compounds)" + }, + { + "input": "Definition: something described as an orally available preparation containing curcumin, quercetin, hyaluronic acid, and chondroitin sulfate with potential radioprotective activity. Upon administration, the glycosaminoglycans may improve barrier function and reduce inflammation and irritation in the genitourinary tract caused by radiotherapy.\nConcepts: cyanate degradation (organonitrogen compound catabolic process)\tCurcumin/Chondroitin Sulfate/Hyaluronic Acid/Quercetin Soft Gels (Pharmacologic Substance)\tStage II Enteropathy-Associated T-Cell Lymphoma (Enteropathy-Associated T-Cell Lymphoma by Ann Arbor Stage)\tGolgi transport vesicle coating (vesicle coating)\tGermline Pathogenicity (Organism Attribute)", + "output": "Curcumin/Chondroitin Sulfate/Hyaluronic Acid/Quercetin Soft Gels (Pharmacologic Substance)" + }, + { + "input": "Definition: Apocynaceae described as a plant genus of the family APOCYNACEAE. Species of this genus contain YOHIMBINE.\nConcepts: Kimmerle's anomaly (Congenital Abnormality)\tAmsonia Walter, 1788 (Apocynaceae)\tRelationships, Professional Patient (Delivery of Health Care)\tRetinoph prematr,stage 3 (Other proliferative retinopathy)\tVacutainer with K2EDTA (Vacutainer)", + "output": "Amsonia Walter, 1788 (Apocynaceae)" + }, + { + "input": "Definition: something described as an orally available small molecule inhibitor of Aurora kinases (AKs) A and B and other currently undisclosed kinases with potential antineoplastic and immunomodulatory activities. Upon oral administration, Aurora kinase inhibitor TT-00420 selectively binds to and inhibits AKs A and B, which may inhibit cell division in tumor cells that overexpress AKs. TT-00420 may also target other not yet disclosed kinases that play a role in tumor-associated inflammation and immune evasion. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of cancer cell types.\nConcepts: Clostridium innocuum (Clostridium)\tMillet (Plant)\tAdverse Event Attributed to Research (Finding)\tRefractory Anaplastic Pleomorphic Xanthoastrocytoma (Neoplastic Process)\tTT 00420 (Organic Chemical)", + "output": "TT 00420 (Organic Chemical)" + }, + { + "input": "Definition: something described as moderate symptoms; limiting instrumental ADL\nConcepts: Communicable Disease Control (Public Health Practice)\tCTCAE Grade 1 Urticaria (Urticaria, CTCAE)\tpositive regulation of response to amylopectin (positive regulation of response to stimulus)\tMyelin oligodendrocyte glycoprotein (GPI-Linked Proteins)\tGrade 2 Accessory Nerve Disorder, CTCAE (Finding)", + "output": "Grade 2 Accessory Nerve Disorder, CTCAE (Finding)" + }, + { + "input": "Definition: Hypoglycemia described as an etiologically heterogenous condition resulting in dysregulated insulin secretion whose cause is present from birth. It is the most common cause of persistent hypoglycemia in neonates, infants and children.\nConcepts: Iron, reduced (Element, Ion, or Isotope)\tHypoglycemias, Persistent Hyperinsulinemic (Hyperinsulinism)\tpositive regulation of chylomicron remnant clearance (Organism Function)\tIVD Test Reagent/Kits, Immunohematology, Blood Grouping, ABO Typing, Cell (Medical Device)\tGrade 1 Headache (Headache, CTCAE)", + "output": "Hypoglycemias, Persistent Hyperinsulinemic (Hyperinsulinism)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as world Health Organization Disability Assessment Schedule 2.0 - 12+24-item Version, Interviewer-administered (WHODAS 2.0 - 12+24-item Version Interviewer-administered) (Reproduced, with permission of WHO, from Measuring Health and Disability: Manual for WHO Disability Assessment Schedule (WHODAS 2.0). Geneva,World Health Organization, 2010 (WHODAS 2.0 12+24-Item Version, Interviewer-Administered www.who.int/classifications/icf/whodasii/en)).\nConcepts: Immunoglobulin Heavy Chain Joining Region (Amino Acid, Peptide, or Protein)\tmodulation by host of viral release from host cell (regulation of viral release from host cell)\tWorld Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered Questionnaire (Intellectual Product)\tTSC complex subunit 1 protein, human (Binding Proteins)\tpolarity (Quantitative Concept)", + "output": "World Health Organization Disability Assessment Schedule 2.0 12+24-item Version Interviewer-administered Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of carbon monoxide present in a sample.\nConcepts: pentylenetetrazole (Pharmacologic Substance)\tCMONOX (Laboratory Procedure)\tAnti-Neutrophil Cytoplasmic Antibody Measurement (Immunologic Tests)\tKNS (Congenital anomaly of visual system)\tmin.ng/ml/(mg/g/d) (Quantitative Concept)", + "output": "CMONOX (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as symptomatic; altered GI function\nConcepts: ADL0324A (ADCS-ADL MCI Questionnaire Question)\tskeletal dysplasia-joint laxity-mental retardation syndrome (Disease or Syndrome)\tGrade 2 Ileal ulcer (Finding)\tregulation of branching involved in mammary cord morphogenesis by fat precursor cell-epithelial cell signalling (regulation of branching involved in mammary gland duct morphogenesis)\tOther purposeful sensing (Purposeful sensory experiences)", + "output": "Grade 2 Ileal ulcer (Finding)" + }, + { + "input": "Definition: Organ or Tissue Function described as embryogenesis is the developmental process by which an embryo is formed and developed. The process begins following fertilization and involves cellular differentiation, leading to the completion of the embryonic stage.\nConcepts: Testicular Cancer pNX TNM Finding v7 (Testicular Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SERPINC1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tDistraction, bone (Closed dislocation)\tIn the last month, how often have you felt that you were effectively coping with important changes that were occurring in your life (Clinical or Research Assessment Question)\tembryonal development (Anatomical transformation relationship)", + "output": "embryonal development (Anatomical transformation relationship)" + }, + { + "input": "Definition: something described as the final stage of the spinal somatic examination in which the nature of the somatic problem is detailed at a segmental level.\nConcepts: Liver-Type Fatty Acid-Binding Protein (Biologically Active Substance)\tPeripheral Schwannoma (Neurilemmoma)\tSegmental Diagnosis (Physical Examination)\tABC - Aneurysmal bone cyst (Bone Cysts)\tdelta-Ureidonorvaline (Amino Acids, Diamino)", + "output": "Segmental Diagnosis (Physical Examination)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators.\nConcepts: Thyroid Hormone Receptor Alpha-1, Oncogene (ERB Oncogene Family)\tgibberellin biosynthesis (carboxylic acid biosynthetic process)\tHormone, Thyroid (Allergen class)\tyoga (Therapeutic or Preventive Procedure)\tosteocyte (Osteoblasts)", + "output": "gibberellin biosynthesis (carboxylic acid biosynthetic process)" + }, + { + "input": "Definition: Gleason Grading System described as only individual discrete well-formed glands.\nConcepts: Group 1 (Gleason Grading System)\tTreatments, Salvage (Therapeutic procedure)\tpostsynaptic neurotransmitter receptor cycle (neurotransmitter receptor cycle)\tDisease Characteristics Table (Data Table)\tfracture; base of skull (Fracture of skull and facial bones)", + "output": "Group 1 (Gleason Grading System)" + }, + { + "input": "Definition: renal capsule formation described as the developmental process pertaining to the initial formation of a mesonephric capsule from unspecified parts. The mesonephric capsule is the tough fibrous layer surrounding the mesonephros, covered in a thick layer of perinephric adipose tissue. It provides some protection from trauma and damage.\nConcepts: Acetogenins (Furans)\tAdaptive Testing (Intellectual Product)\tLactobacillus acidophilus/Streptococcus thermophilus/Bifidobacterium lactis/L. rhamnosus/B. longum/B. bifidum-based probiotic supplement (Pharmacologic Substance)\tPhysiological Malfunction Arising from Mental Factor (NEUROTIC DISORDERS, PERSONALITY DISORDERS, AND OTHER NONPSYCHOTIC MENTAL DISORDERS)\tmesonephric capsule formation (renal capsule formation)", + "output": "mesonephric capsule formation (renal capsule formation)" + }, + { + "input": "Definition: something described as small cell lung carcinoma that is not amenable to surgical resection.\nConcepts: regulation of definitive erythropoiesis (regulation of erythrocyte differentiation)\tUnresectable Lung Small Cell Carcinoma (Neoplastic Process)\tBPI1-Spouse's Occupation (BPI Questionnaire Question)\tYAF1 (Gene or Genome)\tOTAMIXABAN (Pharmacologic Substance)", + "output": "Unresectable Lung Small Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Qualitative Concept described as organ that has two lobes or is divided into two lobes.\nConcepts: maintenance of epithelial cell apical/basal polarity (maintenance of apical/basal cell polarity)\tabnormality; smear cervix (Diseases Component)\tBilobular (Qualitative Concept)\tCURIE (Quantitative Concept)\tNeonatal unilateral epileptic spasm (Disease or Syndrome)", + "output": "Bilobular (Qualitative Concept)" + }, + { + "input": "Definition: Fusion Protein Expression described as a fusion protein that results from a t(1;3)(p36;q23-25). This fusion protein expression is seen in virtually all cases of epithelioid hemangioendothelioma and is unique to this neoplasm.\nConcepts: Micrococcus sedentarius ZoBell and Upham 1944 (Micrococcus)\tPlannedContingentOnRelationship.comment (Published Comment)\tWWTR1-CAMTA1 Fusion Protein Expression (Cell or Molecular Dysfunction)\tconvergent extension involved in organogenesis (convergent extension)\tPartial Retinal Arterial Occlusion (Disorders of choroid and retina)", + "output": "WWTR1-CAMTA1 Fusion Protein Expression (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Finding described as increased chance of harm during the time period immediately following the delivery of an offspring / child\nConcepts: metarubricyte (Erythroblasts)\tMoving around in different locations (Daily or Recreational Activity)\tPostpartum Risk (Finding)\tRAND-36 - Health Limit Vigorous Activities (RAND-36 Questionnaire Question)\tIfex/Mesnex/Taxol (Therapeutic or Preventive Procedure)", + "output": "Postpartum Risk (Finding)" + }, + { + "input": "Definition: College student described as students attending public postsecondary institutions offering 2-year degree programs and transfer components.\nConcepts: Community College Students (College student)\tFLOWMETER, NONBACK-PRESSURE COMPENSATED, BOURDON GAUGE (Medical Device)\tHow Often Experienced Difficulty Sitting up Because Abdominal Muscle Weakness (Clinical or Research Assessment Question)\tvisual loss (General visual observation)\tDissolve - RouteOfAdministration (RouteByMethod)", + "output": "Community College Students (College student)" + }, + { + "input": "Definition: Benign Cervical Soft Tissue Neoplasm described as an uncommon benign smooth muscle neoplasm that arises from the cervix.\nConcepts: Cervical Leiomyoma (Fibroid Tumor)\tpeptide pheromone secretion (peptide pheromone export)\tIsosorbide (Diuretics, Osmotic)\tAxillary Lymph Node (lymph nodes)\tDT-PACE Plus Bortezomib (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "Cervical Leiomyoma (Fibroid Tumor)" + }, + { + "input": "Definition: something described as this attribute specifies the numerator unit for the presentation strength of a product.\nConcepts: bacteriocin transport (Cell Function)\tHas presentation strength numerator unit (Concept model attribute)\tMalignant Lung Tumor (Lung Neoplasms)\tUHDR131B (Intellectual Product)\tProstate Carcinoma pN0 TNM Finding v8 (Prostate Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Has presentation strength numerator unit (Concept model attribute)" + }, + { + "input": "Definition: something described as patchy (irregular) increase in bone density of one or more of the phalanges of the third toe. This can take on many forms depending on severity and distribution as can be seen on x-rays.\nConcepts: Tubes, Esophageal, Decompression (Medical Device)\tPolycystic Kidney Disease 1 Like 1 wt Allele (Gene or Genome)\tINCB040093 (Organic Chemical)\tsouth america (Americas)\tPatchy sclerosis of 3rd toe phalanx (Abnormality of the phalanges of the 3rd toe)", + "output": "Patchy sclerosis of 3rd toe phalanx (Abnormality of the phalanges of the 3rd toe)" + }, + { + "input": "Definition: Wounds and Injuries described as act of inflicting permanent physical damage to oneself, such as cutting off or destroying a limb or other part of the body. Compare SELF INFLICTED WOUNDS.\nConcepts: self inflicted injury (mental health)\tHearing Aid Programming/Testing Software (Software, Device Programming/Testing)\tmevalonate pyrophosphate decarboxylase activity (Molecular Function)\tCongenital malabsorptive diarrhea due to paucity of enteroendocrine cells (Disease or Syndrome)\tQUALITY CONTROL SLIDES (Medical Device)", + "output": "self inflicted injury (mental health)" + }, + { + "input": "Definition: Biologically Active Substance described as a rho GDP-dissociation inhibitor subtype that has a unique C-terminal alpha helical membrane-binding domain. It is found bound to CYTOPLASMIC VESICLES such as those associated with the GOLGI APPARATUS.\nConcepts: Dysfunction, Vocal Cord (Finding of function of vocal cords)\theme formation (pigment biosynthetic process)\tpituitary protein 7B2 (Nerve Tissue Proteins)\tarea 8 alpha of Vogts (Body Part, Organ, or Organ Component)\trho Guanine Nucleotide Dissociation Inhibitor gamma (Biologically Active Substance)", + "output": "rho Guanine Nucleotide Dissociation Inhibitor gamma (Biologically Active Substance)" + }, + { + "input": "Definition: something described as catalysis of the reaction: quercetin 3,3'-bissulfate + 3'-phosphoadenosine 5'-phosphosulfate = quercetin 3,3',7-trissulfate + adenosine 3',5'-bisphosphate.\nConcepts: hepatomegaly (Hepatomegaly)\tupregulation of DNA endoreduplication (positive regulation of DNA-dependent DNA replication)\t3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity (sulfotransferase activity)\tspinal cord injury (Spinal Cord Diseases)\tEyelid Surgery Scissors (Medical Device)", + "output": "3'-phosphoadenylyl-sulfate:quercetin-3,3'-bissulfate 7-sulfotransferase activity (sulfotransferase activity)" + }, + { + "input": "Definition: Eukaryote described as a family of MITES in the subclass ACARI. It includes the single genus Varroa.\nConcepts: 11: 14950427-14946626 (Chromosome 11 Physical Location)\tMature T-Cell and NK-Cell Lymphoma (Peripheral T-cell lymphomas NEC)\tFloor - story of building (HL7 Vocabulary Version 2.5)\tFreezers, Blood Bank, Plasma (Freezer)\tVarroidae (Mites)", + "output": "Varroidae (Mites)" + }, + { + "input": "Definition: Stem cells described as an undifferentiated stromal cell with the ability to develop into the cells that form distinct mesenchymal tissues; such as bone, muscle, connective tissue, blood vessels, and lymphatic tissue. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C43423\" active clinical trials using this agent.\nConcepts: leukemia; aleukemic (Neoplastic Process)\tmesenchymal cell (Multipotent Stem Cells)\ttorula cerevisiae/yeast plan (Pharmacologic Substance)\tFeline Osteosarcoma (Neoplastic Process)\tProsthodontic Dental Knives (Medical Device)", + "output": "mesenchymal cell (Multipotent Stem Cells)" + }, + { + "input": "Definition: something described as the \"electrode, flexible suction coagulator, reprocessed\" is intended to be used endoscopically to provide simultaneous suction of fluids and coagulation of tissue. This device is indicated for reuse/reprocessing.\nConcepts: viral budding (viral process)\tHeme b Cytochromes (Enzyme)\tEREG wt Allele (Gene or Genome)\tELECTRODE, FLEXIBLE SUCTION COAGULATOR, REPROCESSED (Medical Device)\tHuman Papillomavirus-Related Cervical Carcinoma (Human Papillomavirus-Related Carcinoma)", + "output": "ELECTRODE, FLEXIBLE SUCTION COAGULATOR, REPROCESSED (Medical Device)" + }, + { + "input": "Definition: Behavior descriptors described as having to do with symptoms, which are signs of a condition or disease.\nConcepts: interleukin-5 biosynthetic process (Molecular Function)\tRECEPTOR ADENOSINE A 03 (Receptor)\tInhaled air (Body Substance)\tEpendymoma (Malignant Glioma)\tsymptomatic (Functional Concept)", + "output": "symptomatic (Functional Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as a 547 nucleotide (nt), noncoding, uncapped single-stranded RNA (ssRNA) containing several polyU-repeats complexed with a polymeric carrier formed by disulfide-crosslinked cationic peptides, with potential immunostimulating activity. Upon intratumoral injection, the ssRNA in CV8102 activates toll-like receptors (TLRs) and retinoic acid-inducible gene I (RIG I; RIG-I; DDX58). This stimulates a T-helper type 1 cell (Th1) response, the production of a variety of pro-inflammatory cytokines and chemokines, and activates a systemic cytotoxic-T-lymphocyte (CTL)-mediated immune response against the tumor cells when simultaneously exposed to tumor-associated antigens (TAAs). The cationic carrier peptides protect the ssRNA from RNase degradation.\nConcepts: CYTOCHEM (Histology)\tGLAND, CIRCUMANAL (Anus)\tLeukocyte Cell Biology (Cytology)\tWounds, Penetrating (Injury or Poisoning)\tCV-8102 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)", + "output": "CV-8102 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Lung Version 4 - Social/Family Well-Being: I am satisfied with my sex life.\nConcepts: FAC01614 (FACT-L Version 4 Questionnaire Question)\tAdjustment Reaction with Brief Depressive Reaction (Mental or Behavioral Dysfunction)\tarsenate ion transmembrane transporter activity (Molecular Function)\tduodenal carcinoma (Primary malignant neoplasm of small intestine)\tChemical Modifier (Drug, Food, Chemical or Biomedical Material)", + "output": "FAC01614 (FACT-L Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Phosphoric Monoester Hydrolases described as sphingosine-1-phosphate phosphatase 2 (399 aa, ~48 kDa) is encoded by the human SGPP2 gene. This protein plays a role in regulating intracellular and extracellular sphingosine-1-phosphate levels.\nConcepts: IFNb-secreting MSCs (Cell)\tSMDDS Version 1.0 - How Difficult to Enjoy Daily Life (SMDDS Version 1.0 Questionnaire Question)\tExo-1,3 beta-D-Glucosidase (Amino Acid, Peptide, or Protein)\tImmunophenotype (Immunology procedure)\tSGPP2 (Biologically Active Substance)", + "output": "SGPP2 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as this syndrome has characteristics of severe growth retardation associated with immunodeficiency. Less than 10 cases have been described in literature. Individuals present with typical clinical and biochemical features of Laron syndrome such as post-natal growth retardation, delayed bone age and facial dysmorphism (prominent forehead, hypoplastic nasal bridge), and low serum IGF-1 concentrations with normal or high GH concentrations. Immunodeficiency has manifestations of moderate lymphopenia which leads to recurrent infections of the skin and respiratory tract. The syndrome is due to mutation in the signal transducer and activator of transcription 5b gene (STAT5b). Transmission is autosomal recessive.\nConcepts: Morphologic artifact, NOS (Urinalysis)\tConfidence Score 1 (5-Point Confidence Scale)\t1 8 cineole (E [Preparations])\tTherapeutic suppression of lactation (Therapeutic procedure)\tLaron-like syndrome (Combined immunodeficiency disease)", + "output": "Laron-like syndrome (Combined immunodeficiency disease)" + }, + { + "input": "Definition: something described as an abnormality of the larynx.\nConcepts: abbreviation (Additional values)\tpeptidyl-sarcosine incorporation (Molecular Function)\tLaryngeal abnormalities (Anatomical Abnormality)\tJuvenile aseptic necrosis (Avascular necrosis of bone)\thuman herpesvirus 4 group (Virus)", + "output": "Laryngeal abnormalities (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as test cods of questionnaire questions associated with the European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: up-regulation of developmental pigmentation (positive regulation of biological process)\tPerihilar Bile Duct Cancer TNM Finding v7 (Finding)\tLip and Oral Cavity Cancer pN2c TNM Finding v7 (Lip and Oral Cavity Cancer pN2 TNM Finding v7)\tCDISC Questionnaire EQ-5D-5L Test Code Terminology (CDISC Questionnaire Terminology)\tHistidine, L-isomer (Pharmacologic Substance)", + "output": "CDISC Questionnaire EQ-5D-5L Test Code Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in fetal progression.\nConcepts: Capecitabine RDT (pyrimidine analog)\tHPAFP (Ligand Binding Protein Gene)\tTarget Anatomic Site Condition Code (Code)\tMalignant Disease Indicator (Finding)\tpediatric nursing (Biomedical Occupation or Discipline)", + "output": "HPAFP (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an insertion of nine nucleotides, GCAGCGTGG, between position 2308 and 2309 of the coding sequence of the EGFR gene.\nConcepts: Vital Signs Baseline Flag (Baseline Flag)\tPulmonary Edema (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tBPIFD2 (LBP gene)\tHER1 c.2308 2309ins9 (EGFR Exon 20 Insertion Mutation)\tregulation of serine protease activity (regulation of peptidase activity)", + "output": "HER1 c.2308 2309ins9 (EGFR Exon 20 Insertion Mutation)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of Chlamydia trachomatis IgG antibody present in a sample.\nConcepts: intrinsic component of postsynaptic endocytic zone membrane (intrinsic component of postsynaptic membrane)\tAbility to Lift a Box to an Overhead Shelf (Clinical or Research Assessment Question)\tExocanthion (Anatomical point of face)\tMIR342 wt Allele (Gene or Genome)\tCTRIGGAB (Laboratory Procedure)", + "output": "CTRIGGAB (Laboratory Procedure)" + }, + { + "input": "Definition: something described as the modification of putrescine by addition of acetyl groups.\nConcepts: putrescine acetylation (polyamine acetylation)\t4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide (Organic fluoride compound)\tHTLV12AB (Laboratory Procedure)\tCHROMOSOMES HUMAN PAIR 09 (Chromosomes, Human)\tAgenesis of pineal gland (Anatomical Abnormality)", + "output": "putrescine acetylation (polyamine acetylation)" + }, + { + "input": "Definition: something described as a question about whether additional anesthesia was administered.\nConcepts: Plant Bark (Plant Epidermis)\tAdditional Anesthesia Agents Used (Intellectual Product)\tactomyosin contractile ring, distal actin filament layer (Cell Component)\tDefined Adverse Event Category Code (Intellectual Product)\tpulmonary; infarction (Abnormality of the vasculature)", + "output": "Additional Anesthesia Agents Used (Intellectual Product)" + }, + { + "input": "Definition: Spinal Cord Diseases described as a group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary.\nConcepts: FOIA Requests (Functional Concept)\tGLUCOSE TRANSPORTER TYPE 004 (Glucose Transporter)\tatrophy muscular sma spinal (Myopathy)\tpositive regulation of antigen processing and presentation of peptide antigen via MHC class Ib (positive regulation of antigen processing and presentation via MHC class Ib)\tUHDR1-Pronate/Supinate: Hands: Right (Intellectual Product)", + "output": "atrophy muscular sma spinal (Myopathy)" + }, + { + "input": "Definition: Intellectual Product described as a subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to morphology findings.\nConcepts: AVL01-List A Recall 6 (After B) Word 13 (ADNI-AVLT Questionnaire Question)\tMorphology (Intellectual Product)\tReceptor Ligands, EGF (Intercellular Signaling Peptides and Proteins)\tpN2 Cutaneous Melanoma v6 (Finding)\tHydrocarbons, Polycyclic (Organic Chemical)", + "output": "Morphology (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of glial cell proliferation.\nConcepts: Cancer Treatment (Therapeutic or Preventive Procedure)\tregulation of glial cell proliferation (Biologic Function)\tconjunctival cyst (Orbital cyst)\tUterine Corpus Carcinoma pT3a TNM Finding v7 (Uterine Corpus Carcinoma pT3 TNM Finding v7)\tAdenoid Cystic Carcinoma of the Prostate (Adenoid Cystic Carcinoma)", + "output": "regulation of glial cell proliferation (Biologic Function)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the maximum concentration of thrombin generated during a thrombin generation test.\nConcepts: Dacrocystitis (Inflammation of specific body systems)\tEndogenous Thrombin Potential Peak Height Measurement (Laboratory Procedure)\tTrigger for Intervention (Finding)\tBCL2 Associated Athanogene 5 Gene (Genes, Regulator)\tFinding During Childbirth Labor (Finding)", + "output": "Endogenous Thrombin Potential Peak Height Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Disease or Syndrome described as an increased amount of arginine levels in the blood.\nConcepts: Serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 5 wt Allele (SERPINB5 gene)\tsingle-stranded DNA 5'-3' exodeoxyribonuclease activity (5'-3' exodeoxyribonuclease activity)\targinase deficiency (Rare Non-Neoplastic Disorder)\tprolymphocyte count (Laboratory Procedure)\tserotonin secretion, neurotransmission (neurotransmitter release)", + "output": "arginase deficiency (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Medical Device described as an endoscope and accessories is a device used to provide access, illumination, and allow observation or manipulation of body cavities, hollow organs, and canals. The device consists of various rigid or flexible instruments that are inserted into body spaces and may include an optical system for conveying an image to the user's eye and their accessories may assist in gaining access or increase the versatility and augment the capabilities of the devices. Examples of devices that are within this generic type of device include cleaning accessories for endoscopes, photographic accessories for endoscopes, nonpowered anoscopes, binolcular attachments for endoscopes, pocket battery boxes, flexible or rigid choledochoscopes, colonoscopes, diagnostic cystoscopes, cystourethroscopes, enteroscopes, esophagogastroduodenoscopes, rigid esophagoscopes, fiberoptic illuminators for endoscopes, incandescent endoscope lamps, biliary pancreatoscopes, proctoscopes, resectoscopes, nephroscopes, sigmoidoscopes, ureteroscopes, urethroscopes, endomagnetic retrievers, cytology brushes for endoscopes, and lubricating jelly for transurethral surgical instruments. This section does not apply to endoscopes that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.\nConcepts: UPD1-Mentation:Motivation/Initiative (UPDRS Questionnaire Question)\tNebulisation use (Functional Concept)\tCAMERA, SURGICAL AND ACCESSORIES (Medical Device)\tStage III Duodenal Neuroendocrine Tumor AJCC v8 (Neoplastic Process)\tSCISSORS FOR CYSTOSCOPE (Medical Device)", + "output": "SCISSORS FOR CYSTOSCOPE (Medical Device)" + }, + { + "input": "Definition: Cardiac internal structure described as this structure includes the thin muscular atrial septum between the two HEART ATRIA, and the thick muscular ventricular septum between the two HEART VENTRICLES.\nConcepts: Underdeveloped tear gland (Aplastic/hypoplastic lacrimal glands)\tHeart Septa (Septum of organ)\tSN (Intellectual Product)\tGastric Neuroendocrine Tumor pN0 TNM Finding v7 (Gastric Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v7)\tchaplain (Person Role Title)", + "output": "Heart Septa (Septum of organ)" + }, + { + "input": "Definition: Qualitative Concept described as the tendency of something to act in a certain manner under given circumstances resulting from natural constitution; nature; quality; orderly arrangement.\nConcepts: DISPOSITION (Qualitative Concept)\tGenome, Microbial (Genome)\tCyclophilin-40 (Immunologic Factor)\tferredoxin:thioredoxin reductase activity (Molecular Function)\tLonicera japonica / ren dong teng (Oriental herbs and natural substances letter L)", + "output": "DISPOSITION (Qualitative Concept)" + }, + { + "input": "Definition: something described as a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antimetabolites.\nConcepts: Vitelline Membrane (Embryonic Structure)\tdibenzo-p-dioxin metabolic process (cellular aromatic compound metabolic process)\tObstructions, Urethral (Urethral Diseases)\tL-2-amino-3-[(N-nitroso)hydroxylamino]propionic acid (Amino Acid, Peptide, or Protein)\tSF-MPQ-2 - Heavy Pain (Short-Form MPQ-2 Questionnaire Question)", + "output": "L-2-amino-3-[(N-nitroso)hydroxylamino]propionic acid (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Uterine Corpus Endometrial Stromal and Related Neoplasms described as a uterine corpus sarcoma originating from the endometrial stroma. It is further subdivided into low grade and high grade endometrial stromal sarcoma.\nConcepts: down regulation of leukocyte adhesion to arterial endothelial cell (negative regulation of leukocyte adhesion to vascular endothelial cell)\tPASAT102 (Intellectual Product)\tSample Size Calculation (Calculation)\tUterine Corpus Endometrial Stromal Sarcoma (Endometrial Stromal Sarcoma)\tKetamine product (Analgesics)", + "output": "Uterine Corpus Endometrial Stromal Sarcoma (Endometrial Stromal Sarcoma)" + }, + { + "input": "Definition: contact person described as the main or principle contact person for a clinical investigator network.\nConcepts: CAIX Protein (Antigens, Neoplasm)\tStage IIIA Esophageal Adenocarcinoma (Postneoadjuvant Therapy Stage III Esophageal Adenocarcinoma AJCC v8)\tTHEAFLAVIN (Chemical Viewed Structurally)\tT-Cell Non-Hodgkin's Lymphoma of the Breast (T-Cell Lymphoma)\tCLINICAL NETWORK CONTACT (Human)", + "output": "CLINICAL NETWORK CONTACT (Human)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: hexose + phosphoramidate = hexose 1-phosphate + NH3.\nConcepts: IVD Panels, Human Genetics, Pharmacogenetic, Substance Abuse (IVD Panels, Human Genetics, Pharmacogenetic)\tphosphoramidate:hexose 1-phosphotransferase activity (phosphotransferase activity, alcohol group as acceptor)\tmeiotic spindle checkpoint (Cell Function)\tcurli secretion complex (transmembrane transporter complex)\tDiagnostic Error (Diagnosis)", + "output": "phosphoramidate:hexose 1-phosphotransferase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: something described as a measurement that describes the pressure of the circulating blood against the walls of the blood vessels. Measurement is taken from extremities other than the right arm.\nConcepts: Vital Signs - Other Extremity Blood Pressure (Diagnostic Procedure)\tstripes of Baillarger (Body Part, Organ, or Organ Component)\tMapped ICD-O-3.1 Morphology Terminology (Intellectual Product)\tThoracic and Lumbosacral Spinal Cord Ependymal Tumor (Neoplastic Process)\tDISH, TISSUE CULTURE (Medical Device)", + "output": "Vital Signs - Other Extremity Blood Pressure (Diagnostic Procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate.\nConcepts: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity (Molecular Function)\tRNA polymerase IV activity (Genetic Function)\tAge in Days at Bone Marrow Analysis (Finding)\troot epidermal cell differentiation (Cell Function)\tSite Initiation Visit Report (Intellectual Product)", + "output": "N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: Stage II Adult Diffuse Large Cell Lymphoma described as ann Arbor Classification: stage II: involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8480\" active clinical trials using this agent.\nConcepts: Stage II Diffuse Large Cell Lymphoma (Stage II Adult Diffuse Large Cell Lymphoma)\tDIED - NATURALLY (Finding)\tDRRI-2 - M: Family Member Wasted Money (DRRI-2 Questionnaire Question)\t18q21.1 (Cell Component)\t17: 31337852-31334805 (Chromosome 17 Physical Location)", + "output": "Stage II Diffuse Large Cell Lymphoma (Stage II Adult Diffuse Large Cell Lymphoma)" + }, + { + "input": "Definition: Non human viruses described as a species of MORBILLIVIRUS causing a severe, often fatal enteritis and pneumonia (PESTE-DES-PETITS-RUMINANTS) in sheep and goats.\nConcepts: Stage IIIC Colon Cancer AJCC v7 (Stage III Colon Cancer AJCC v7)\tDistress About Illness or Treatment to Those Close to You (Intellectual Product)\tkidney tumor (Neoplastic disease)\tCOXEN Score 17 (COXEN Sensitivity Scale)\tPseudorinderpest virus (Virus)", + "output": "Pseudorinderpest virus (Virus)" + }, + { + "input": "Definition: something described as a protein complex located at the mitochondrial ribosome tunnel exit that is involved in efficient translation and protein complex assembly.\nConcepts: anti-inflammatory/antimicrobial/analgesic aqueous mouth rinse (Biological Response Modifiers)\tADVERSE EVENT (Pathologic Function)\tElevated urinary norepinephrine (Elevated urinary catecholamines)\tmelanoma antigen family A2 (LINC01194 gene)\tCbp3p-Cbp6 complex location (protein-containing complex)", + "output": "Cbp3p-Cbp6 complex location (protein-containing complex)" + }, + { + "input": "Definition: Complication due to and following neuromuscular block described as failure of neuromuscular block reversal agents to antagonise a neuro muscular blocking drug.\nConcepts: hydroxymethylsilanetriol oxidase activity (Molecular Function)\tovary right (Body Part, Organ, or Organ Component)\tDysarthric speech (Speech & Language Disorders)\tInability to reverse neuromuscular block (Complication due to and following neuromuscular block)\tAUGMENTATION OF ORAL DIURETIC THERAPY (Therapeutic or Preventive Procedure)", + "output": "Inability to reverse neuromuscular block (Complication due to and following neuromuscular block)" + }, + { + "input": "Definition: something described as an ophthalmic nanoemulsion consisting of the tartrate salt form of brimonidine, an imidazole derivative and selective alpha-2 adrenergic receptor agonist, with potential anti-inflammatory and vasoconstrictive activities. Upon ophthalmic instillation, brimonidine tartrate nanoemulsion OCU-300 reduces intraocular pressure by promoting the outflow and decreasing the production of aqueous humor and may reduce ocular erythema through direct vasoconstriction. Additionally, brimonidine may disrupt leukocyte extravasation into the ocular tissue, inhibit nociception and reduce inflammation associated with ocular graft-versus-host disease (oGvHD). The nanoemulsion formulation may enhance distribution of brimonidine to target tissues, thereby allowing more of the active drug to reach underlying ocular tissue.\nConcepts: bone marrow preservation (Laboratory Procedure)\tJoystick (Device Component or Accessory)\tBrimonidine Tartrate Nanoemulsion OCU-300 (Pharmacologic Substance)\tSkin Pigmentation Disorders (Skin lesion)\tFACT-Taxane Version 4 - I Have Trouble Hearing (FACT-Taxane Version 4 Questionnaire Question)", + "output": "Brimonidine Tartrate Nanoemulsion OCU-300 (Pharmacologic Substance)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to mow the lawn using a power mower, not a riding mower.\nConcepts: Mucositis (Digestive System Disorders)\themopoietic organ development (gland development)\tFaecal incontinence not due to organic disease (Behavioral Symptoms)\tMowing The Lawn with a Power Mower (Intellectual Product)\tAMG211 (Amino Acid, Peptide, or Protein)", + "output": "Mowing The Lawn with a Power Mower (Intellectual Product)" + }, + { + "input": "Definition: cellular localization described as any process in which a substance or cellular entity, such as a protein complex or organelle, is transported to, and/or maintained in, a specific location within a membrane.\nConcepts: venereal wart (Non-Cancer Diagnosis)\tCapable of only limited selfcare, confined to bed or chair more than 50% of waking hours (Finding)\tlocalization within membrane (cellular localization)\tMastication, function (Gastrointestinal Process)\tmetallochaperone complex location (protein-containing complex)", + "output": "localization within membrane (cellular localization)" + }, + { + "input": "Definition: something described as the directed movement of a lipid hydroperoxide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: Immunotherapy (Immunomodulation)\tAcq hypertrichosis lanuginosa (Hypertrichosis lanuginosa)\tlipid hydroperoxide transport (organic substance transport)\tascending aorta morphogenesis (Organ or Tissue Function)\tComprehensive prolonged 120 minute new phone consult homeopathic intake (Phone conversations with or without ICD diagnosis)", + "output": "lipid hydroperoxide transport (organic substance transport)" + }, + { + "input": "Definition: Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma by AJCC v8 Stage described as stage III includes: (T1, N1, M0); (T2, N1, M0); (T3, Any N, M0). T1: Pheochromocytoma measuring less than 5 cm in greatest dimension, with no extra-adrenal invasion. T2: Pheochromocytoma measuring 5 cm or more in greatest dimension or paraganglioma-sympathetic of any size, with no extra-adrenal invasion. T3: Tumor of any size with invasion into surrounding tissues (e.g., liver, pancreas, spleen, kidneys). N1: Regional lymph node metastasis. M0: No distant metastasis.\nConcepts: TSCYC108 (Intellectual Product)\tMTBIGAAB (Laboratory Procedure)\tup regulation of macrophage antigen processing and presentation (Cell Function)\tHepatic Hemodialysis Units (Medical Device)\tStage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8 (Neoplastic Process)", + "output": "Stage III Adrenal Gland Pheochromocytoma and Sympathetic Paraganglioma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Aggressive Non-Hodgkin Lymphoma described as an uncommon type of lymphoma. It constitutes approximately 10% of cases of lymphoblastic lymphoma. Approximately 75% of cases reported in a literature review involved patients who were less than 18 years of age. The most commonly affected sites are the skin, bone, soft tissue, and lymph nodes. It has a high remission rate with a median survival of approximately 60 months.\nConcepts: Cyclophosphamide/Fluorouracil/Methotrexate/Vincristine (Therapeutic or Preventive Procedure)\tActual Number of Subjects (Group Attribute)\tStage IIIC Colorectal (Colon or Rectal) Cancer (Stage III Colorectal Cancer AJCC v8)\tAlbumin-bound Paclitaxel Regimen (Regimen Used to Treat Malignant Fallopian Tube Neoplasm)\tPrecursor B-lymphoblastic lymphomas (Precursor cell lymphoblastic lymphoma)", + "output": "Precursor B-lymphoblastic lymphomas (Precursor cell lymphoblastic lymphoma)" + }, + { + "input": "Definition: Manufactured Object described as brushes designed to remove debris from the surface of devices, instruments, and/or working areas. These brushes typically include a set of tufts of bristles or other flexible materials that are mounted along a single plane at the distal end of a handle or radiate from a central shaft for proper manipulation. Dedicated cleaning brushes of the appropriate shape, size, and materials are available for cleaning devices and instruments (e.g., burs, dilators, endoscopes), prostheses (e.g., dentures, hearing aids), and labware and for general surface cleaning (including housekeeping) in healthcare facilities.\nConcepts: Vasodilating agent, NOS (Cardiovascular Agents)\tCleaning Brushes (Brush device)\tdeath domain binding (protein domain specific binding)\tLeptotrichia, NOS (BACTERIA AND RICKETTSIAE)\tMGC166915 (Transcription factor genes)", + "output": "Cleaning Brushes (Brush device)" + }, + { + "input": "Definition: Yeast Proteins described as SWP82, around 82 KD, is one of the subunits of SWI/SNF complex from S. cerevisiae.\nConcepts: Carcinoma, Cholangiocellular (Malignant hepatobiliary neoplasms)\tdefences host (Immune System Processes)\tMAPK phosphatase activity involved in regulation of innate immune response (Molecular Function)\tKnowledge: Lipid Disorder Management (Knowledge Health Condition)\tSWP82 (Yeast Proteins)", + "output": "SWP82 (Yeast Proteins)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Adult Report (PedsQL Neuromuscular Module Version 3.0 Young Adult Report) In the past one month, how much of a problem has this been for you: It takes me a long time to bathe or shower.\nConcepts: NCCN-FACT FBRSI-24 Version 2 - Content With Quality of My Life (Intellectual Product)\tPQL01-Long Time to Bathe/Shower (Intellectual Product)\tpositive regulation of encysted zoospore germination on or near host (positive regulation of spore germination on or near host)\tT-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster (Genes, T-Cell Receptor)\tGravid Uterus Adjusted Maternal Body Weight Gain (Finding)", + "output": "PQL01-Long Time to Bathe/Shower (Intellectual Product)" + }, + { + "input": "Definition: something described as workstations designed to obtain and process the digital data and images acquired by ophthalmic instruments, by still image and video cameras (including pictures from slit lamps), and/or from patient records. These workstations typically acquire the information directly from measuring and imaging instruments (e.g., refraction, corneal topography), information systems (e.g., picture archiving and communication), and administrative data (e.g., patient identification, schedule of tests and appointments). Ophthalmic workstations typically consist of a high-speed digital computer, high-definition printers, magneto-optical disks, input and output devices, and processors; they usually follow the instructions of specialized software for data and image processing. The workstations may work as an autonomous unit or be installed as a component of or interact with hospital information systems, including picture archiving and communication systems. Dedicated ophthalmic workstations, intended to be used to facilitate refractive diagnoses, laser treatments, and the performance of cataract surgery, are also available.\nConcepts: compact substance of bone (Bone Tissue, Human)\tOphthalmology Workstations (Manufactured Object)\tLacrimal Gland Carcinoma Clinical Distant Metastasis TNM Finding v8 (Lacrimal Gland Carcinoma Clinical TNM Finding v8)\tcupula development (Organ or Tissue Function)\tMauss's area 9 (Body Part, Organ, or Organ Component)", + "output": "Ophthalmology Workstations (Manufactured Object)" + }, + { + "input": "Definition: Bladder Anastomotic Leak, CTCAE described as life-threatening consequences; urgent operative intervention indicated\nConcepts: Every Three Hours (Intervals of hours)\tpleurisy (Disorder of pleura and pleural cavity)\tGrade 4 Bladder anastomotic leak (Bladder Anastomotic Leak, CTCAE)\tQIDS-SR - Energy Level (QIDS-SR Questionnaire Question)\tUreter Part (Ureter)", + "output": "Grade 4 Bladder anastomotic leak (Bladder Anastomotic Leak, CTCAE)" + }, + { + "input": "Definition: Finding described as any deviation from the normal concentration of the HDL2a subfraction in the blood circulation. An HDL2B particle is defined as an HDL particle with a size of 9.7-12 nm.\nConcepts: HP802247 (Biological Factors)\tAbnormal HDL2b concentration (Finding)\tAllogeneic CD123R(EQ)28zeta/EGFRt+ T Cells (Pharmacologic Substance)\tIntramammary Suspension Dosage Form (Intramammary Dosage Form)\t5 Butyl 2 pyridinedicarboxylic Acid (Pharmacologic Substance)", + "output": "Abnormal HDL2b concentration (Finding)" + }, + { + "input": "Definition: Disproportionate short-trunk short stature described as a type of disproportionate short stature characterized by a short trunk but a average-sized limbs with onset in infancy.\nConcepts: negative regulation of plus-end directed microtubule sliding (regulation of plus-end directed microtubule sliding)\tDistal Bile Duct Cancer Pathologic Primary Tumor TNM Finding v8 (Finding)\tShort-trunk dwarfism, identifiable in infancy (Disproportionate short-trunk short stature)\tglycine betaine biosynthetic process (Molecular Function)\tlysine 6-dehydrogenase activity (oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor)", + "output": "Short-trunk dwarfism, identifiable in infancy (Disproportionate short-trunk short stature)" + }, + { + "input": "Definition: something described as an abnormality of the physiological functioning of B cells.\nConcepts: Abnormality of B cell physiology (Finding)\tSimple Breath-holding Spell (Sign or Symptom)\tupregulation of inflammatory response (regulation of inflammatory response)\tFAC02816 (Intellectual Product)\tnegative regulation of protein tyrosine kinase activity (negative regulation of peptidyl-tyrosine phosphorylation)", + "output": "Abnormality of B cell physiology (Finding)" + }, + { + "input": "Definition: Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v8 described as breast cancer in which no regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only.\nConcepts: Anaemia (Non-Neoplastic Hematologic and Lymphocytic Disorder)\tBreast Carcinoma pN0 TNM Finding v8 (Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tDrainage Systems, Pleural (Device system)\tEntamoeba Casagrandi & Barbagallo 1897 (Sarcodina, Amoeba and Sporozoa)\tBiliary tumor (Biliary Tract Diseases)", + "output": "Breast Carcinoma pN0 TNM Finding v8 (Breast Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: something described as the ability to repress or the practice of repressing one's behavior, impulsive reactions, emotions, or desires.\nConcepts: Egg White IgE Antibody RAST Score Measurement (Laboratory Procedure)\tEntrezGene ID (NCI Thesaurus Property)\tSelf-control (Social Behavior)\tputrescine biosynthesis from arginine via N-carbamoylputrescine (Molecular Function)\tCongenital amegakaryocytic thrombocytopenia (Amegakaryocytic thrombocytopenia)", + "output": "Self-control (Social Behavior)" + }, + { + "input": "Definition: something described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to species of Leptospira, a genus of finely coiled, motile bacteria of the family Leptospiraceae. Leptospira interrogans is typically the species that is pathologic to humans, causing leptospirosis. Leptospirosis is acquired directly by contact with the urine or tissue of infected animals (e.g., rodents, dogs) or indirectly by contact with contaminated water, soil, or vegetation.\nConcepts: Nurse simple new in-facility 10 minutes (Health Care Activity)\tColorectal Cancer pNX TNM Finding v6 and v7 (Colorectal Cancer Pathologic Regional Lymph Nodes TNM Finding v6)\tEmployment status (Employee, Occupational & Job Characteristics)\tIVD Test Reagent/Kits, Serology, Bacteria, Leptospira Species, IgG Antibody (Medical Device)\ttechnique development (Research Activities)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Leptospira Species, IgG Antibody (Medical Device)" + }, + { + "input": "Definition: Anatomy Qualifier described as located in tissues surrounding a tumor.\nConcepts: PODCI2-Able to Do More at School (Intellectual Product)\tAutosomal recessive limb girdle muscular dystrophy type 2P (Autosomal recessive muscular dystrophy with limb girdle distribution)\tFOSI - I Have Cramps in My Stomach Area (Intellectual Product)\tPeritumoral (Spatial Concept)\tParathyroid dysgenesis (Anatomical Abnormality)", + "output": "Peritumoral (Spatial Concept)" + }, + { + "input": "Definition: Carbohydrate metabolism disorder marker described as a hexose which is almost identical to glucose except that orientation of -H and -OH on carbon 4 are exchanged, making it an epimer at C-4 of glucose (in Fisher projection). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68482\" active clinical trials using this agent.\nConcepts: Galactopyranose (Indicator, Reagent, or Diagnostic Aid)\tPrecursor T Lymphoblastic Lymphoma (Precursor cell lymphoblastic lymphoma)\t51 ANTIHISTAMINE DRUGS (medications and vaccines)\tRE (Physicians; Physician/Osteopath)\tI-SMAD binding (SMAD binding)", + "output": "Galactopyranose (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: AlkB Enzymes described as a dioxygenase and alkylation repair homolog that demethylates RNA by oxidative demethylation. It specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA in higher eukaryotes. It can also demethylate N(6)-methyladenosine in SINGLE-STRANDED DNA.\nConcepts: Sequence Read Count (Count)\tAlkB Homolog 5, RNA Demethylase (Enzyme)\tcog'tv stim&nrtrns educ.ndvd (Therapeutic or Preventive Procedure)\toogenesis, establishment and maintenance of oocyte localization (localization of cell)\t9,10 (9', 10')-carotenoid-cleaving dioxygenase activity (Molecular Function)", + "output": "AlkB Homolog 5, RNA Demethylase (Enzyme)" + }, + { + "input": "Definition: Eukaryote described as a species of parasitic nematodes in the family Capillariidae. C. hepaticum causes hepatic capillariasis in rodents and other mammals. Its life cycle is completed in a single host species but the eggs must mature outside of the host body prior to infecting a new host.\nConcepts: BRIEF (Clinical or Research Assessment Questionnaire)\tSSX2B Positive (Laboratory or Test Result)\tCalodium hepaticum (Eukaryote)\tChanges in skin (Clinical or Research Assessment Question)\tdown-regulation of interleukin-6 production (regulation of interleukin-6 production)", + "output": "Calodium hepaticum (Eukaryote)" + }, + { + "input": "Definition: DEPDC5 gene described as human DEPDC5 wild-type allele is located within 22q12.2-q12.3 and is approximately 153 kb in length. This allele, which encodes GATOR complex protein DEPDC5, is involved in the modulation of signaling by Ras-related GTP-binding proteins. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci and with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection.\nConcepts: FFEVF1 (Gene or Genome)\tINTERVENTIONS (Classification)\tcellular response to nitrogen levels (cellular response to nutrient levels)\tForm FDA 1572 (Intellectual Product)\tInfectious Myositides (Soft Tissue Infection)", + "output": "FFEVF1 (Gene or Genome)" + }, + { + "input": "Definition: Perineal care described as caring for a client/patient's postpartum perineal skin to relieve discomfort and/or promote her perineal healing. Service is billed in 15-minute increments.\nConcepts: hypothalamus gonadotrophin-releasing hormone neuron development (forebrain neuron development)\tPostpartum perineal care each 15 minutes (Postpartum Period)\tSPONASTRIME (Fanconi Anemia)\tFAC071-Limit Social Activity, I am Tired (Intellectual Product)\tRGO - Reciprocat gait orthosis (Walking orthosis)", + "output": "Postpartum perineal care each 15 minutes (Postpartum Period)" + }, + { + "input": "Definition: Quantitative Concept described as the frequency of caffeine consumed on a regular basis.\nConcepts: Frequency of Routine Caffeine Intake (ACC-AHA Measure)\tSIRIUS RED (Organic Chemical)\tT-Cell Proliferation of Uncertain Malignant Potential (Neoplastic Process)\tNE (Geographic Area)\tDecreased iodine diet (Therapeutic or Preventive Procedure)", + "output": "Frequency of Routine Caffeine Intake (ACC-AHA Measure)" + }, + { + "input": "Definition: something described as cyclin-dependent kinase inhibitor-2A (CDKN2A) goes by the colloquial designation p16, which is sometimes referred to as p16(INK4). The alpha transcript of CDKN2A has been shown to encode p16(INK4a), a recognized tumor suppressor that induces a G1 cell cycle arrest by inhibiting the phosphorylation of the RB protein by the cyclin-dependent kinases CDK4 and CDK6. The beta transcript of CDKN2A encodes p14(ARF). The predicted 132-amino acid p14(ARF) is shorter than the corresponding mouse protein, p19(ARF), and the 2 proteins share only 50% identity. However, both proteins have the ability to elicit a p53 response, manifest in the increased expression of both CDKN1A and MDM2, and resulting in a distinctive cell cycle arrest in both the G1 and G2/M phases. Two unrelated proteins encoded by the INK4A-ARF locus function in tumor suppression. ARF binds to MDM2 and promotes the rapid degradation of MDM2. This interaction is mediated by the E1-beta-encoded N-terminal domain of ARF and a C-terminal region of MDM2. ARF-promoted MDM2 degradation is associated with MDM2 modification and concurrent p53 stabilization and accumulation. The p19(Arf) tumor suppressor inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors. These effects correlate with but do not strictly depend upon inhibition of rRNA biosynthesis or cell cycle arrest, are not mimicked by p53, and require neither p53 nor Mdm2. Arf mutants lacking conserved amino acid residues 2-14 do not block rRNA synthesis and processing or inhibit cell proliferation. Evolution may have linked a primordial nucleolar Arf function to Mdm2 and p53, creating a more efficient checkpoint-signaling pathway for coordinating ribosomal biogenesis and cell cycle progression.\nConcepts: metanephric glomerular epithelium development (glomerular epithelium development)\tHow often have you found you stopped and started again several times when you urinated (Clinical or Research Assessment Question)\tRibosomal Biogenesis Pathway (Molecular Function)\tphagolysosome (Secondary lysosome)\tProblem of Device to Self-Test (Device Evaluation Result)", + "output": "Ribosomal Biogenesis Pathway (Molecular Function)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.\nConcepts: quality of sleep (Finding)\t15q11.2-q21.3 (Cell Component)\tTPP biosynthesis (organophosphate biosynthetic process)\tbiles (Bile and Pancreatic Fluid)\tCivil protection systems (Governmental or Regulatory Activity)", + "output": "TPP biosynthesis (organophosphate biosynthetic process)" + }, + { + "input": "Definition: something described as human MUCL1 wild-type allele is located in the vicinity of 12q and is approximately 4 kb in length. This allele, which encodes mucin-like protein 1, may be involved in the modulation of epithelial basement membrane structure. The expression of the gene may be a marker for metastatic breast cancer because it is expressed at elevated levels in breast carcinomas displaying lymph node metastases.\nConcepts: Apparent Size (Quantitative Concept)\t3T3 Cell, NIH (Mouse Cell Line)\t18S rRNA binding (Genetic Function)\tMucin-Like 1 wt Allele (Gene or Genome)\tGrade 2 Neonatal Administration Site Complication, AE (Neonatal Administration Site Complication, AE)", + "output": "Mucin-Like 1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Phenomenon or Process described as a phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.\nConcepts: Mucositis, NOS (Nonsuppurative inflammation)\tAnti-CD123 ADC IMGN632 (Pharmacologic Substance)\tFounder Effects (Genetic Phenomena)\tR1530 (Antineoplastic Enzyme Inhibitor)\tspin labels (Free Radicals)", + "output": "Founder Effects (Genetic Phenomena)" + }, + { + "input": "Definition: Recurrent Diffuse Astrocytoma described as the reemergence of diffuse astrocytoma in childhood after a period of remission.\nConcepts: Recurrent Childhood Diffuse Astrocytoma (Childhood Diffuse Astrocytoma)\talbino (Amino Acid Metabolism, Inborn Errors)\tComplete duplication of the phalanges of the hallux (Duplication of phalanx of hallux)\tglycine metabolism (Molecular Function)\tNPRL3 (Amino Acid, Peptide, or Protein)", + "output": "Recurrent Childhood Diffuse Astrocytoma (Childhood Diffuse Astrocytoma)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of Herpes Simplex virus 1/2 IgG antibody present in a sample.\nConcepts: Climb (Moving around)\trndx perinatal risk (Finding related to perinatal risk factor)\tHerpes Simplex Virus 1/2 IgG Antibody Measurement (Laboratory Procedure)\tDecreased CSF valine concentration (Finding)\toccupational exposure (Employee, Occupational & Job Characteristics)", + "output": "Herpes Simplex Virus 1/2 IgG Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as adhesive tapes made of plastic material (e.g., polyethylene, PVC). These tapes are usually long and narrow strips supplied in rolls. They may be available as foams or nonwoven films; they are usually waterproof. Plastic tapes are intended to attach objects (dressings, bandages, tubes, catheters) to the body.\nConcepts: FLOT1 wt Allele (Gene or Genome)\t(S)-dihydroorotate:quinone oxidoreductase activity (oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor)\tPlastic Tapes, Adhesive (Adhesive tape)\tSMPD4 (Amino Acid, Peptide, or Protein)\t{log}.[TCID 50]/uL (Quantitative Concept)", + "output": "Plastic Tapes, Adhesive (Adhesive tape)" + }, + { + "input": "Definition: Medical Device described as endoscopes designed for direct insertion through the anal canal in the lower gastrointestinal tract for visual examination, biopsy, and treatment of lesions of the interior of the anal canal and lower rectum (e.g., fissures, fistulae, hemorrhoids). These devices are rigid endoscopes that may include fiberoptic light sources.\nConcepts: RING Finger Protein 66 (Amino Acid, Peptide, or Protein)\tCilium (membrane prolongation)\tAnoscopes (SCOPES AND CAMERAS)\tOffice of the Director (Health Care Related Organization)\tFIGO Stage IVB Ovarian Carcinoma (Ovarian cancer stage IV)", + "output": "Anoscopes (SCOPES AND CAMERAS)" + }, + { + "input": "Definition: rectal/anal described as a repeated, painful urge to defecate without excreting stool.\nConcepts: Familial steroid-resistant nephrotic syndrome with sensorineural deafness (Disease or Syndrome)\tTWIN (Multiple Birth Offspring)\tSEND Microscopic Findings Test Name (CDISC SEND Terminology)\tDetailed new 30 minutes out-of-office massage therapy intake (Health Care Activity)\tDefecation urge painful (Abnormal large intestine physiology)", + "output": "Defecation urge painful (Abnormal large intestine physiology)" + }, + { + "input": "Definition: something described as stage IV includes: IVA (Any T, N0, M1a, Any G); IVB (Any T, N1, Any M, Any G); (Any T, Any N, M1b, Any G). N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M1a: Distant metastasis to lung. M1b: Metastasis to other distant sites.\nConcepts: Stage IV Bone Cancer (Neoplastic Process)\tPug (Toy Breed)\tspinovestibular fibers (Spinothalamic Tracts)\tEhlers-Danlos syndrome arterial type E-D (Connective Tissue Diseases)\tPOIKILO (Laboratory Procedure)", + "output": "Stage IV Bone Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of methionine from one side of a membrane to the other.\nConcepts: S-phase of mitotic cell cycle (S Phase)\tAbnormality of cartilage of nose (Abnormality of the external nose)\tstage IVB uterine sarcoma (Neoplastic Process)\tmethionine transmembrane transporter activity (sulfur amino acid transmembrane transporter activity)\tTesticular Cancer cN2 TNM Finding v8 (Finding)", + "output": "methionine transmembrane transporter activity (sulfur amino acid transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a digoxin test system is a device intended to measure digoxin, a cardiovascular drug, in serum and plasma. Measurements obtained by this device are used in the diagnosis and treatment of digoxin overdose and in monitoring levels of digoxin to ensure appropriate therapy.\nConcepts: Sinhala (Language)\tHistological Type of New Non-Melanoma Tumor Event (CPTAC Questions)\tInsulin Like Growth Factor Receptors (Receptor)\tRADIOIMMUNOASSAY, DIGOXIN (125-I), GOAT ANTIBODY, 2ND ANTIBODY SEP. (Indicator, Reagent, or Diagnostic Aid)\tForgetfulness (Intellectual Product)", + "output": "RADIOIMMUNOASSAY, DIGOXIN (125-I), GOAT ANTIBODY, 2ND ANTIBODY SEP. (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a paired evagination of embryonic pharyngeal endoderm, which is located between pharyngeal arches two and three, and which contributes to the formation of the middle ear and palatine tonsils.\nConcepts: ASS1 Gene (Gene Mutation)\tHemoglobin Barts to Total Hemoglobin Ratio Measurement (Laboratory Procedure)\tclinical significance (Other Finding)\tLead Site aV6 (Electrocardiograph Lead Placement Location)\tSecond branchial pouch (Embryonic Structures)", + "output": "Second branchial pouch (Embryonic Structures)" + }, + { + "input": "Definition: organonitrogen compound biosynthetic process described as the chemical reactions and pathways resulting in the formation of interleukin-6.\nConcepts: Simple ear (Ear structure)\tcondiment (Food)\tDeazaadenosine (Purine Nucleosides)\tinterleukin-6 anabolism (cytokine biosynthesis)\tFutuximab/Modotuximab Mixture (Angiogenesis Inhibitors)", + "output": "interleukin-6 anabolism (cytokine biosynthesis)" + }, + { + "input": "Definition: Reproductive Behavior described as behavior patterns of those practicing CONTRACEPTION.\nConcepts: Prostheses, Vascular (Cardiovascular prosthesis)\tCDISC Clinical Classification NHLBI CAD Grade Test Name Terminology (CDISC Clinical Classification Terminology)\t10^3/[HPF] (Unit of Number Concentration)\tBIE - Bullous ichthyosiform erythroderma (Skin Histology)\tContraception Behaviors (Social Behavior)", + "output": "Contraception Behaviors (Social Behavior)" + }, + { + "input": "Definition: something described as a calcium salt formulation of gemcabene, a dialkyl ether dicarboxylic acid with antihyperlipidemic activity.\nConcepts: Placental Hormone Activity Alteration (Hormonal Change)\tReceptor Protein-Tyrosine Kinase TKT (Receptor Protein-Tyrosine Kinases)\tStreptonivicin (Medicinal product categorized by disposition)\tGemcabene Calcium (Organic Chemical)\tNSCLC102 (Intellectual Product)", + "output": "Gemcabene Calcium (Organic Chemical)" + }, + { + "input": "Definition: Immunologic Factor described as a 9-residue human leukocyte antigen (HLA)-restricted fragment of carcinoembryonic antigen (CEA). CEA:571-579 peptide, which has the amino acid sequence YLSGANLNL, may elicit a cytotoxic T lymphocyte (CTL) immune response against tumors expressing CEA. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2622\" active clinical trials using this agent.\nConcepts: Spermatozoa, Progressive/Spermatozoa (Laboratory Procedure)\tmixed glioma, adult brainstem (Adult Mixed Glioma)\tMinute Times Microgram Per Milliliter Per Milligram Per Gram Per Day (Quantitative Concept)\tUrostomy Perforation (Urinary Tract Perforation)\tCEA PEP 1-6D (Amino Acid, Peptide, or Protein)", + "output": "CEA PEP 1-6D (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Congenital Abnormality described as a kind of bronchopulmonary sequestration that is completely discrete from the normal lung and is surrounded by separate pleura.\nConcepts: central B cell selection (Biologic Function)\tTriglycerides/HDL Cholesterol (Lipids measurement)\tExtralobar sequestration (Bronchopulmonary Sequestration)\tPPK (Gene or Genome)\tDie Cutting Formulation Process (Laboratory Procedure)", + "output": "Extralobar sequestration (Bronchopulmonary Sequestration)" + }, + { + "input": "Definition: NCI Thesaurus Role described as a role used to assert a relationship between a surgical procedure and its target anatomy, specifically that a particular procedure sometimes results in complete excision of the target anatomy. This role is applicable to procedures or techniques that involve excision of solid tissues or organs, and where complete excision is explicit or can be inferred. The domain and range for this role are 'Clinical or Research Activity' and 'Anatomic Structure, System, or Substance', respectively.\nConcepts: cellular response to L-glutamate (cellular response to drug)\t(mL/h)/g (Quantitative Concept)\tProcedure May Have Completely Excised Anatomy (NCI Thesaurus Role)\tmental retardation-sparse hair syndrome (Disease or Syndrome)\tErythrocyte Cell Clumps (Cell Count)", + "output": "Procedure May Have Completely Excised Anatomy (NCI Thesaurus Role)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process.\nConcepts: mandible; agenesis (Aplasia/Hypoplasia of the mandible)\tnegative regulation of microRNA catabolic process (regulation of miRNA catabolic process)\tManagement of plant sterol ester intake (Health Care Activity)\tRenal mucinous tubular and spindle cell carcinoma (Renal Cell Carcinoma)\tBenign scapuloperoneal muscular dystrophy with early contractures (Genetic Diseases, X-Linked)", + "output": "negative regulation of microRNA catabolic process (regulation of miRNA catabolic process)" + }, + { + "input": "Definition: Reduced visual acuity described as diminished clarity of vision without optical correction (glasses and/or contacts).\nConcepts: Electrodes, (e.g., apnea monitor), per pair (Reusable Devices)\tpeptide YY (Peptide Hormone Gene)\tVaginal germ cell malignant tumour (Germ cell tumor)\tBody Mass Index Greater than or Equal to 30 (Body Mass Index Greater Than or Equal to 23)\tDecreased Uncorrected Visual Acuity (Reduced visual acuity)", + "output": "Decreased Uncorrected Visual Acuity (Reduced visual acuity)" + }, + { + "input": "Definition: something described as a rare genetic limb reduction defects syndrome with characteristics of bilateral radial aplasia/hypoplasia manifesting with absent/short forearms in association with anogenital abnormalities (for example hypospadias or imperforate anus). Additional features reported include hydrocephalus and absent preaxial digits. There have been no further descriptions in the literature since 1993.\nConcepts: sodium:inorganic phosphate symporter activity (Molecular Function)\tAUMC Infinity Predicted Normalized by Surface Area (Area Under First Moment Curve)\tErythrina L. (Phaseoleae)\tCane Corso (Non-Sporting Breed)\tAbsent radius, anogenital anomalies syndrome (Congenital anomaly of perineum)", + "output": "Absent radius, anogenital anomalies syndrome (Congenital anomaly of perineum)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had pain that kept them from doing things they wanted to do.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Calibration, Neuroendocrine Hormone (Medical Device)\tBenign Ovarian Transitional Cell Tumor (Neoplastic Process)\tregulation of chondrocyte hypertrophy (Cell Growth Regulation)\tWash (Biomedical or Dental Material)\tPain Keeps Me From Doing Things I Want to Do (Intellectual Product)", + "output": "Pain Keeps Me From Doing Things I Want to Do (Intellectual Product)" + }, + { + "input": "Definition: Plant described as a plant genus of the family FABACEAE.\nConcepts: 1-(2-((1-carboxy-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylic acid (Pharmacologic Substance)\tHEMODIALYZER, RE-USE, HIGH FLUX (Medical Device)\tClover (Trifolieae)\toff label use (Off-Label Treatment)\tCyproterone acet [malignancy] (Progesterone derivative)", + "output": "Clover (Trifolieae)" + }, + { + "input": "Definition: Lambda Z described as the first order rate constant associated with the terminal (log-linear) portion of the curve, calculated within a dosing interval.\nConcepts: SS1(dsFv)PE38 (Immunologic Factor)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, GH1 (Medical Device)\tUrine xenobiotic (Finding)\tLAMZTAU (Lambda Z)\tUrinary Bladder Nephrogenic Adenoma (Disease or Syndrome)", + "output": "LAMZTAU (Lambda Z)" + }, + { + "input": "Definition: Meliaceae described as a plant genus. Members contain LIMONOIDS.\nConcepts: regulation of defecation rhythm (regulation of defecation)\tinsertions (RouteByMethod)\tTrichilia (Meliaceae)\tTubulointerstitial microganismal infiltration (Abnormal tubulointerstitial morphology)\tnegative regulation of fibroblast migration (negative regulation of cell migration)", + "output": "Trichilia (Meliaceae)" + }, + { + "input": "Definition: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor described as catalysis of the reaction: 2 cob(II)alamin + NAD+ = 2 aquacob(III)alamin + NADH + H+.\nConcepts: PURPLE BACT (Gram-negative bacillus)\tAiredale terrier (Terrier)\tMaterial Name with Attribute Name (Name)\tketo-D-gluconate metabolism (ketogluconate metabolic process)\tvitamin B(12a) reductase activity (oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor)", + "output": "vitamin B(12a) reductase activity (oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor)" + }, + { + "input": "Definition: peptidyl-tyrosine modification described as the uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase.\nConcepts: down regulation of glycine import (negative regulation of response to drug)\tresponse to temperature stimulus (Biologic Function)\tpeptidyl-tyrosine uridylylation (protein uridylylation)\tPhenobarbital embryopathy (Fetus with drug damage)\tODI v2.1a - Travelling (Intellectual Product)", + "output": "peptidyl-tyrosine uridylylation (protein uridylylation)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an eph family receptor found in a number of tissues including BRAIN; LUNG; KIDNEY; PANCREAS; INTESTINE; and HEART. During embryogenesis EphB3 receptor is expressed at high levels in the brain.\nConcepts: Pitch (Audiological test feature)\tEPH B 003 RECEPTOR (Receptor)\tFaceplant (Sign or Symptom)\tEnterobacter hormaechei (Bacterium)\tPsychological testing comprehensive assessment each 15 minutes (Therapeutic or Preventive Procedure)", + "output": "EPH B 003 RECEPTOR (Receptor)" + }, + { + "input": "Definition: something described as a measure of linguistic development based on a person's ability to accurately repeat nonsense words.\nConcepts: Non-word Repetition (Research or Clinical Assessment Tool)\tautologous oxidized ovarian tumor cell lysate vaccine (Pharmacologic Substance)\tHypermethylation (DNA Methylation)\tModest Extremity Pain (Clinical or Research Assessment Answer)\tGrade 1 Oligospermia (Finding)", + "output": "Non-word Repetition (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as tumor measuring 2 cm or less in greatest dimension limited to the thyroid.\nConcepts: positive regulation of interferon-alpha production (regulation of interferon-alpha production)\tNeonatal Complication (Pathologic Function)\tanti-TRAIL receptor 2 monoclonal antibody HGS-ETR2 (Amino Acid, Peptide, or Protein)\tNon-specified HCPCS II hospital service or procedure reference code no charge (Tracking code use with or without ICD diagnosis)\tPapillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pT1 TNM Finding v8 (Finding)", + "output": "Papillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pT1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a variation in the amino acid sequence for DNA mismatch repair protein Msh2.\nConcepts: late preg.asesmnt ea.15min (Procedure with a clinical finding focus)\tMutS Protein Homolog 2 Protein Variant (Cell or Molecular Dysfunction)\tARPP-21 (Amino Acid, Peptide, or Protein)\ttrisomy 12 (Disease or Syndrome)\tFrustration (Mental and Behavioral Signs and Symptoms)", + "output": "MutS Protein Homolog 2 Protein Variant (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as argan oil from seeds is consumed raw in the southwest part of Morocco.\nConcepts: Argania (Plant)\tMucositis Oral (Finding)\tSet of regions of back (Surface region of back)\tERT - Neutral Responded as Sadness (Intellectual Product)\tCOLECTOMY (Large intestine excision)", + "output": "Argania (Plant)" + }, + { + "input": "Definition: Mediastinitis described as inflammation of the mediastinum, the area between the pleural sacs.\nConcepts: Inflammations, Mediastinum (Chest Pain)\tlignan degradation (Molecular Function)\tGrade 4 Night blindness (Finding)\tPremature breast development at puberty (endocrine disorders of female reproductive system)\tPODCI Pediatric Parent-Reported Version - Get In and Out of Bed (PODCI Pediatric Parent-Reported Version Questionnaire Question)", + "output": "Inflammations, Mediastinum (Chest Pain)" + }, + { + "input": "Definition: Supraglottic Cancer TNM Finding v7 described as a pathologic finding about one or more characteristics of supraglottic cancer, following the rules of the TNM AJCC v7 classification system. The pathologic staging requires the use of all information obtained in clinical staging and in histologic study of the surgically resected specimens.\nConcepts: Organizational Contact (contact person)\tstromal myosis (Benign stromal tumor)\tBone Cancer pM1b TNM Finding v7 (Bone Cancer pM1 TNM Finding v7)\tDisk Degenerations (Intervertebral disc disorders NEC)\tSupraglottic Cancer Pathologic TNM Finding v7 (Supraglottic Cancer TNM Finding v7)", + "output": "Supraglottic Cancer Pathologic TNM Finding v7 (Supraglottic Cancer TNM Finding v7)" + }, + { + "input": "Definition: something described as high grade B-cell lymphoma with MYC and BCL2 or BCL6 rearrangements that is resistant to treatment.\nConcepts: Open biopsy (Surgical incisions)\tGt, Transducin G Protein (GTP-Binding Proteins)\ttransforming growth factor beta receptor signaling pathway involved in axial mesodermal cell fate specification (transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification)\tneural control (Organ or Tissue Function)\tRefractory Double-Hit Lymphoma (Neoplastic Process)", + "output": "Refractory Double-Hit Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Plant Proteins described as dietary protein from EDIBLE GRAINS.\nConcepts: Social Communication Disorders (Actual Impaired Interactive Behavior)\tIPA0102D (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tGrain Proteins [EXT] (Immunologic Factor)\tIndex Date (Temporal Concept)\tautologous CD133-positive brain tumor stem cell mRNA-pulsed autologous dendritic cell vaccine (Immunologic Factor)", + "output": "Grain Proteins [EXT] (Immunologic Factor)" + }, + { + "input": "Definition: cation transmembrane transport described as the directed movement of isoleucine across a membrane.\nConcepts: MIR92A2 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tIn-Ear Tinnitus Therapy Units (Tinnitus Therapy Units)\tisoleucine transmembrane transport (amino acid transmembrane transport)\tIntracranial Thrombus (Disease or Syndrome)\tlycopene metabolic process (Molecular Function)", + "output": "isoleucine transmembrane transport (amino acid transmembrane transport)" + }, + { + "input": "Definition: something described as a question about whether an individual's eyes hurt because of the wind.\nConcepts: Have Eye Pain in Wind (Intellectual Product)\tHypodermic needles (SYRINGES/NEEDLES)\tzymogen binding (Molecular Function)\tPDZ and LIM Domain 3 wt Allele (Gene or Genome)\tintake dietary (Finding)", + "output": "Have Eye Pain in Wind (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inositol stimulus.\nConcepts: endocrocin formation (secondary metabolite biosynthetic process)\tUNIT, ELECTROLYSIS, AC-POWERED, OPHTHALMIC (Medical Device)\tTourniquet, device (Equipment and Supplies)\tresponse to inositol (response to organic substance)\tGrade 2 Pancreatic Enzymes Decreased, CTCAE (Pancreatic Enzymes Decreased, CTCAE)", + "output": "response to inositol (response to organic substance)" + }, + { + "input": "Definition: Organism Function described as the process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.\nConcepts: artery; occlusion, retina (partial) (Lesion of brain)\tEnteric Coated Tablet Dose Form (Biomedical or Dental Material)\th.mmol/L/(mg/g) (Quantitative Concept)\tneuron generation (Organism Function)\textrapyramidal signs (Sign or Symptom)", + "output": "neuron generation (Organism Function)" + }, + { + "input": "Definition: Tunica Media described as the smooth muscle tissue present in the tunica media which is the middle layer of the wall of an artery.\nConcepts: Artery Smooth Muscle Tissue (Tissue)\tDuodenum and Ampulla of Vater Neuroendocrine Tumor pT2 TNM Finding v8 (Finding)\tpositive regulation of interleukin-2-mediated signalling pathway (positive regulation of cytokine-mediated signaling pathway)\torlandin metabolism (Molecular Function)\tCHK1 Inhibitor MK-8776 (Antineoplastic Enzyme Inhibitor)", + "output": "Artery Smooth Muscle Tissue (Tissue)" + }, + { + "input": "Definition: Duration described as the intended length of time for the activity. EXAMPLE(S): 6 weeks may be the duration for a composite activity. P7D may be used to represent a duration of 7 days. OTHER NAME(S): NOTE(S):\nConcepts: NCIWG Cheson CLL 1996 Oncology Response Criteria (Tumor Response Criterion)\tDefined Subject Activity Group Duration (Duration)\tDevice Over The Counter Product Indicator (Qualitative Concept)\tCusatuzumab (Amino Acid, Peptide, or Protein)\t3C Viral Proteases (Cysteine Endopeptidases)", + "output": "Defined Subject Activity Group Duration (Duration)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in immune system processes and is involved in angiogenesis.\nConcepts: Prostheses, Ear Auricle (Prosthesis)\tMOB1, MOUSE, HOMOLOG OF (CXC Cytokine Gene)\t4-nitrotoluene metabolism (Molecular Function)\t68Ga-NODAGA-ZIGF-1R:4\uff1a40 (Indicator, Reagent, or Diagnostic Aid)\tBurkholderia cepacia complex (Bacterium)", + "output": "MOB1, MOUSE, HOMOLOG OF (CXC Cytokine Gene)" + }, + { + "input": "Definition: Recombinant Proteins described as a recombinant dimeric fusion protein consisting of the extracellular CD2-binding domain of the human leukocyte function-associated antigen 3 (LFA-3; CD58) linked to the Fc portion of human immunoglobulin G1 (IgG1) with potential immunosuppressive activity. Alefacept binds to the CD2 receptor expressed on the majority of T lymphocytes, blocking the binding of endogenous LFA-3, located on antigen-presenting cells (APCs), to the CD2 receptor; the activation and proliferation of T lymphocytes in response to LFA-3 binding is thus inhibited. In addition, binding of the IgG1 moiety of this agent to the Fc gamma receptor on the surface of natural killer (NK)cells may bridge NK cells and target T lymphocytes, initiating NK cell-mediated apoptosis of T lymphocytes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C65220\" active clinical trials using this agent.\nConcepts: positive regulation of innate immune response (regulation of innate immune response)\tPODCI Adolescent Self-Reported Version - Competitive Sports Limited by: Instructions (PODCI Adolescent Self-Reported Version Questionnaire Question)\tBothered by Itching Skin (Intellectual Product)\tTimolol Maleate (Timolol in ophthalmic dosage form)\tLFA-3 IgG1 Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "LFA-3 IgG1 Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a family of prenylated protein tyrosine phosphatases that plays a role in both phosphotyrosine catabolism and signal transduction pathways, which in turn modulate many different cellular processes.\nConcepts: ribonuclease V activity (Genetic Function)\tPOU5F1 Staining Method (Laboratory Procedure)\tL-Tyrosine, N-(N-(N-(N2-L-arginyl-L-lysyl)-L-alpha-aspartyl)-L-valyl)- (Thymopoietins)\tfever hemorrhagic (Haemorrhages NEC)\tPTPN4A (Protein Family)", + "output": "PTPN4A (Protein Family)" + }, + { + "input": "Definition: regulation of maintenance of mitotic sister chromatid cohesion described as any process that modulates the frequency, rate or extent of maintenance of mitotic sister chromatid cohesion, telomeric.\nConcepts: Compensatory Hyperinsulinemia (Disease or Syndrome)\tAntithrombin III Antigen (Immunologic Tests)\tPediatric Rehabilitation Medicine - Physicians (Professional or Occupational Group)\tHIST3H3 (Histone H3)\tregulation of maintenance of mitotic sister chromatid cohesion, telomeric (regulation of maintenance of mitotic sister chromatid cohesion)", + "output": "regulation of maintenance of mitotic sister chromatid cohesion, telomeric (regulation of maintenance of mitotic sister chromatid cohesion)" + }, + { + "input": "Definition: something described as any process that decreases the concentration of calcium ions in the cytosol.\nConcepts: nuclear matrix organization and biogenesis (nucleus organization)\t1(2H)-Isoquinolinone, 8-Chloro-2-phenyl-3-((1S)-1-(9H-purin-6-ylamino)ethyl)- (Pharmacologic Substance)\tFractures, Compression (Fracture)\tBeryllium Disease (Disease or Syndrome)\treduction of calcium ion concentration in cytosol (regulation of cytosolic calcium ion concentration)", + "output": "reduction of calcium ion concentration in cytosol (regulation of cytosolic calcium ion concentration)" + }, + { + "input": "Definition: something described as involvement of ipsilateral regional lymph nodes. Note: The regional lymph nodes include preauricular (parotid), submandibular, and cervical.\nConcepts: Ocular Adnexal Lymphoma pN1 TNM Finding v7 (Ocular Adnexal Lymphoma Pathologic Regional Lymph Nodes TNM Finding v7)\tELA1 (Protein or Enzyme Type Measurement)\tGrade 2 Cytomegalovirus Infection Reactivation, CTCAE (Cytomegalovirus Infection Reactivation, CTCAE)\tNicotine nasal spray (Nicotine-containing product in nasal dose form)\tDietary & Nutritional Service Providers; \"Dietitian, Registered\", \"Nutrition, Gerontological\" (Professional or Occupational Group)", + "output": "Ocular Adnexal Lymphoma pN1 TNM Finding v7 (Ocular Adnexal Lymphoma Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: something described as any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation.\nConcepts: up regulation of macroautophagy (regulation of macroautophagy)\tAnti-DNA Antibodies (Immunologic Tests)\tISG15 transferase activity (Molecular Function)\tMurine hepatitis virus (Genus Betacoronavirus)\tBendamustine-Rituximab (Therapeutic or Preventive Procedure)", + "output": "up regulation of macroautophagy (regulation of macroautophagy)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation.\nConcepts: HDAC5 (Gene or Genome)\tCSS0115 (Intellectual Product)\tSepta interalveolaria mandibulae (Zone of body of mandible)\tendodermal cell differentiation (Cell Differentiation process)\tchromatin accessibility complex location (ISWI-type complex)", + "output": "HDAC5 (Gene or Genome)" + }, + { + "input": "Definition: Aza Compounds described as a synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is converted intracellularly into mono, di-, and triphosphate derivatives, which incorporate into RNA and inhibit protein synthesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C291\" active clinical trials using this agent.\nConcepts: Riboazauracil (Orotidylate Decarboxylase Inhibitor)\tFresh (Biospecimen)\tsulfate transmembrane transport (Cell Function)\tThree tier interpretation model: Moderate risk (Finding)\tULCER SKIN (Disease of Skin and Appendages)", + "output": "Riboazauracil (Orotidylate Decarboxylase Inhibitor)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in protein phosphorylation and limb development.\nConcepts: 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo- (General anesthetic drugs)\tbirt-hogg-dube syndrome (Skin Diseases, Genetic)\tHarrier (Mammal)\tHSP70I (HSPA1A gene)\tSerine/Threonine Kinase 32B Gene (Gene or Genome)", + "output": "Serine/Threonine Kinase 32B Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a fusion protein that is encoded by the HEY1/NCOA2 fusion gene. This protein contains the N-terminal basic helix-loop-helix domain of hairy/enhancer-of-split related with YRPW motif protein 1 fused to the C-terminal region of the nuclear receptor coactivator 2 protein, which includes its CREB binding and histone acetyl transferase domains.\nConcepts: brain wave (Nervous System Physiological Phenomena)\tPenile Cancer pNX TNM Finding v8 (Finding)\tGAD-7 - Problems Made it Difficult to Work, Take Care of Things, or Get Along with Other People (GAD-7 Questionnaire Question)\tOXYBUTYNIN CHLORIDE (ANTISPASMODICS,URINARY)\tHairy/Enhancer-of-Split Related With YRPW Motif Protein 1/Nuclear Receptor Coactivator 2 Fusion Protein (Fusion protein)", + "output": "Hairy/Enhancer-of-Split Related With YRPW Motif Protein 1/Nuclear Receptor Coactivator 2 Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: something described as an aggressive mature T-cell non Hodgkin lymphoma involving the skin. It is characterized by the presence of a polymorphic cellular infiltrate which contains neoplastic small to medium sized T-lymphocytes.\nConcepts: Cutaneous Angioimmunoblastic T-Cell Lymphoma (Malignant neoplasm of skin)\tascospore release from ascus (Cell Function)\tSDTM-SIZE (Intellectual Product)\tadministrable dosage form (Biomedical or Dental Material)\tN-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity (catalytic activity, acting on a glycoprotein)", + "output": "Cutaneous Angioimmunoblastic T-Cell Lymphoma (Malignant neoplasm of skin)" + }, + { + "input": "Definition: something described as anterior schisis (cleft or cleavage) of vertebral bodies.\nConcepts: Chondroitin Sulfate B (chondroitin sulfates)\tMyxomatous degen mitral valve (Mitral Valve Insufficiency)\tE3 (Molecular Function)\twet bed (Psychiatric problem)\tAnterior clefting of vertebral bodies (Finding)", + "output": "Anterior clefting of vertebral bodies (Finding)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as venoms from jellyfish; CORALS; SEA ANEMONES; etc. They contain hemo-, cardio-, dermo- , and neuro-toxic substances and probably ENZYMES. They include palytoxin, sarcophine, and anthopleurine.\nConcepts: Colorectal Cancer pTis Intraepithelial TNM Finding (Finding)\tVenom, Cnidarian (Amino Acid, Peptide, or Protein)\tcytoplasmic mRNP granule (cytoplasmic ribonucleoprotein granule)\tCSS05-Interrupted Attempt, Describe (Intellectual Product)\ttRNA aminoacylation for protein translation (Genetic Function)", + "output": "Venom, Cnidarian (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as klebsiella spp. serological reagents are devices that consist of antigens and antisera, including antisera conjugated with a fluorescent dye (immunofluorescent reagents), that are used in serological tests to identify Klebsiella spp. from cultured isolates derived from clinical specimens. The identification aids in the diagnosis of diseases caused by bacteria belonging to the genus Klebsiella and provides epidemiological information on these diseases. These organisms can cause serious urinary tract and pulmonary infections, particularly in hospitalized patients.\nConcepts: ANTISERA, ALL TYPES, KLEBSIELLA SPP. (Indicator, Reagent, or Diagnostic Aid)\tStayed Off Cigarettes More than One Year Since Diagnosis (Finding)\tMicrosatellite Stability Assessment (Diagnostic Procedure)\tGDS0115 (GDS Questionnaire Question)\tAnger Control Assistance (Cognitive Therapy)", + "output": "ANTISERA, ALL TYPES, KLEBSIELLA SPP. (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Abuse recovery status described as a feeling of self-worth, self-confidence, and self-respect.\nConcepts: Self Esteem (Mental Process)\tAAUGIX (Cardiovascular examination)\tantiglaucoma drug (Pharmacologic Substance)\tCN III formation (cranial nerve formation)\tMitral insufficiency (Heart valve disease)", + "output": "Self Esteem (Mental Process)" + }, + { + "input": "Definition: Hypersensitivity skin testing described as a preparation of an antigenic component of an infectious agent that is administered to a patient in order to determine whether previous exposure to the agent has occurred, and/or to assess the integrity of the patient's cellular immune system. Depending on the clinical situation, the appearance of a delayed (cellular) hypersensitivity response, which manifests as an area of induration and erythema at the injection site, i.e. a positive test result, may indicate previous exposure to a particular infectious agent.\nConcepts: Stage I Lymphoepithelioma of Nasopharynx (Stage I Nasopharyngeal Carcinoma)\tSkin test (Diagnostic Procedure)\tTractus rubroolivaris (Brain stem part)\tMembranous Nephropathy - Idiopathic (Disease or Syndrome)\taminocarb (Pesticides)", + "output": "Skin test (Diagnostic Procedure)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Severe human suffering: Witnessed it.\nConcepts: Picrogram/Deciliter (Quantitative Concept)\ttermination of MAPK activity (negative regulation of MAP kinase activity)\tCSS05-Number of Actual Attempts-Since (C-SSRS Already Enrolled Subjects Questionnaire Question)\twater-soluble vitamin metabolic process (Molecular Function)\tLEC-5 Standard Version - Severe Human Suffering: Witnessed (LEC-5 Standard Version Questionnaire Question)", + "output": "LEC-5 Standard Version - Severe Human Suffering: Witnessed (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Finding described as abnormally high concentration of lactate in the blood.\nConcepts: pain in shoulder (Sign or Symptom)\tl/h/m2 (Quantitative Concept)\tacetyl-CoA synthesis from ethanol (acetyl-CoA biosynthetic process)\tfractalkine (Cytokine Gene)\tElevated Lactate (Abnormal Blood Chemistry and Hematology Test Result)", + "output": "Elevated Lactate (Abnormal Blood Chemistry and Hematology Test Result)" + }, + { + "input": "Definition: Elevated cholesterol with elevated triglycerides described as rather uncommon form of familial hyperlipemia characterized by the presence of lipoproteins of abnormal composition; the main abnormal lipoproteins are called beta-VLDL and have a different apoprotein content and a higher proportion of cholesterol relative to triglyceride than normal VLDL.\nConcepts: PQL1512 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)\tFamilial dysbetalipoproteinemia (Hyperlipoproteinemias)\tSystems, Single-Payer (Financing, Organized)\tCryoglobulin (Paraproteins)\tSensory Filtering (Nervous System Physiological Processes)", + "output": "Familial dysbetalipoproteinemia (Hyperlipoproteinemias)" + }, + { + "input": "Definition: Property or Attribute described as to determine the number or amount of something; the result of this activity.\nConcepts: subfornical region (Body Location or Region)\tregulation of L-glutamine biosynthetic process (regulation of cellular amino acid biosynthetic process)\tcount (Quantitative Concept)\tdeath receptor 5, human (Tumor Necrosis Factor Receptor)\tEncapsulated Cytarabine (phospholipids)", + "output": "count (Quantitative Concept)" + }, + { + "input": "Definition: Dissociative, conversion and factitious disorders described as a disruption and/or discontinuity in the normal integration of consciousness, memory, identity, emotion, perception, body representation, motor control, and behavior. Clinical presentations of dissociation may include a wide variety of symptoms, including experiences of depersonalization, derealisation, emotional numbing, flashbacks of traumatic events, absorption, amnesia, voice hearing, interruptions in awareness, and identity alteration.\nConcepts: reaction; dissociative (Dissociative states)\tCRK7 (Gene or Genome)\tCuldoscopes (Medical Device)\tSIGLEC9 protein, human (Immunologic Factor)\tCognition Clock Test (Research or Clinical Assessment Tool)", + "output": "reaction; dissociative (Dissociative states)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Rivermead Post-Concussion Symptoms Questionnaire (RPQ) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: mitochondrial cytochrome bc(1) complex assembly (mitochondrial respiratory chain complex assembly)\tPerformedObservationResult.uncertaintyCode (Uncertainty Code)\tRivermead Post Concussion Symptoms Questionnaire Questionnaire Test Name (Intellectual Product)\tpeptidoglycan-based cell wall biogenesis (cell wall biogenesis)\tsodium/iodide symporter activity (Molecular Function)", + "output": "Rivermead Post Concussion Symptoms Questionnaire Questionnaire Test Name (Intellectual Product)" + }, + { + "input": "Definition: something described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of body fluids to detect and/or measure the level of one or more of a group (at least 20) of immunologically distinct proteins found in blood and tissue fluids (complement components). These proteins are synthesized by the liver and are normally present in the blood as functionally inactive molecules. Complement components of the classical and final pathway are numbered from C1 to C9 (except C4), and those of the alternative path are designated by single capitals (e.g., B, D), except C3, which is common to both paths. Lower-case suffixes (i.e., a, b, c) denote fragments into which a component has been split. In living organisms, complement components can interact with cell membranes to destroy viruses, bacteria, and cells; abnormal serum levels of complement components may be due to either inherited or acquired diseases.\nConcepts: regulation of myoblast proliferation (regulation of cell population proliferation)\tthyroid hormone binding (Molecular Function)\tIVD Test Reagent/Kits, Immunoassay, Protein, Complement Component (Medical Device)\tGA733 (Amino Acid, Peptide, or Protein)\tpicokatal (SI unit of catalytic amount)", + "output": "IVD Test Reagent/Kits, Immunoassay, Protein, Complement Component (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the regulation of calcium signaling to T lymphocytes and other cells.\nConcepts: Vinblastine sulphate (Vinca-Domain Binding Agent)\tCNU (Conceptual Entity)\tGET2 (Gene or Genome)\tspinomedullary junction (Body Space or Junction)\tSTDs (Virus Diseases)", + "output": "GET2 (Gene or Genome)" + }, + { + "input": "Definition: Lugano Classification Limited Stage Adult Non-Hodgkin Lymphoma AJCC v8 described as stage IE: Single extralymphatic site in the absence of nodal involvement.\nConcepts: clathrin coating of Golgi vesicle (clathrin coat assembly)\tRemovable Orthodontic Appliances (Medical Device)\tVisual Feedback Mirrors (Mirror)\tIDH1/IDH2 Sequencing (Laboratory Procedure)\tLugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8 (Neoplastic Process)", + "output": "Lugano Classification Stage IE Adult Non-Hodgkin Lymphoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: something described as the ability of the knee to move past its normal range of motion, (knee hyperextension is greater than 10 degrees).\nConcepts: Pulmonary vein part of pericardial sac (Body Part, Organ, or Organ Component)\tDPDE4 (Enzyme)\tOrder Thermoplasmatales (Archaeon)\tPODCI Adolescent Self-Reported Version - Have Pain Relief (Intellectual Product)\tKnee joint over-flexibility (Increased range of knee movement)", + "output": "Knee joint over-flexibility (Increased range of knee movement)" + }, + { + "input": "Definition: Intellectual Product described as an axiom that indicates the inclusion and exclusion criteria for possible study subjects.\nConcepts: positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)\tBone Cancer Pathologic Primary Tumor TNM Finding v7 (Finding)\tTIRL (Rule)\tnucleic acid inhibitor (antagonists & inhibitors)\tFinAnaly Output (system output)", + "output": "TIRL (Rule)" + }, + { + "input": "Definition: Biological Science Disciplines described as the study of tissues and cells under a microscope.\nConcepts: OXcarbazepine (Carbamazepine and derivatives)\tCommunicative (Mental association)\tmyofibroblast (Entire cell)\thistology (Biomedical Occupation or Discipline)\tNeuron Conduction Induction (Neurologic Effect)", + "output": "histology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Adrenergic Agents described as a sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension.\nConcepts: SPL REMS Stakeholder Terminology (SPL Risk Evaluation and Mitigation Strategies Terminology)\tinhibition of (+)-kotanin formation (regulation of (+)-kotanin biosynthetic process)\tTFBS Ablation (Transcription Factor Binding Site Mutation)\tCough (Clinical or Research Assessment Question)\t4-Chloro-a,a-dimethylphenethylamine (Amphetamines)", + "output": "4-Chloro-a,a-dimethylphenethylamine (Amphetamines)" + }, + { + "input": "Definition: Tumor Necrosis Factor Blocker [EPC] described as a Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80972\" active clinical trials using this agent.\nConcepts: pancreatic delta cell development (Cell Function)\tCERTOLIZUMAB (Monoclonal Antibodies)\ttaurine-pyruvate aminotransferase activity (aminotransferase activity)\tdown-regulation of leucyl-transfer ribonucleate synthetase activity (Molecular Function)\tphosphate ion transmembrane transporter activity (inorganic anion transmembrane transporter activity)", + "output": "CERTOLIZUMAB (Monoclonal Antibodies)" + }, + { + "input": "Definition: Country described as former Netherlands overseas territory in the Lesser Antilles in the West Indies. It had included the islands of Aruba, Bonaire, Curacao, Saba, St. Eustatius, and the southern part of St. Martin. The Netherlands Antilles dissolved on October 10, 2010.\nConcepts: Visual Prompts will not Clear (Medical Device Operates Differently Than Expected)\tNN (Country)\tLeptospirosis Nephropathy (Disease or Syndrome)\tPatient Health Questionnaire - 15 Item Questionnaire Test Code (Intellectual Product)\talphav-beta5 integrin-vitronectin complex location (Cell Component)", + "output": "NN (Country)" + }, + { + "input": "Definition: organic anion transport described as the process in which triose phosphate (glyceraldehyde 3-phosphate) is transported across a membrane. Glyceraldehyde 3-phosphate is any organic three carbon compound phosphate ester.\nConcepts: Stolon (Plant Part)\tPost-Surgical Complication (Pathologic Function)\tTIL Research (Basic Cancer Research)\ttriose phosphate transmembrane transport (Molecular Function)\tneurofilaments (Intermediate Filaments)", + "output": "triose phosphate transmembrane transport (Molecular Function)" + }, + { + "input": "Definition: membrane protein complex described as any protein complex that is part of the outer mitochondrial membrane.\nConcepts: Glandular cell neoplasm (Neoplastic Process)\tMonoclonal Antibody Nuclear Imaging Procedure Kit/Trays (Procedure Kit/Trays, Nuclear Imaging)\touter mitochondrial membrane protein complex (Cell Component)\tLimb Salvage (Therapeutic or Preventive Procedure)\t4,4-dimethyl-3-oxopentanoate decarboxylase activity (carboxy-lyase activity)", + "output": "outer mitochondrial membrane protein complex (Cell Component)" + }, + { + "input": "Definition: Abnormal morphology of female internal genitalia described as an abnormality of the fallopian tube.\nConcepts: ADP-dependent glucokinase activity (Molecular Function)\tvery long-chain acyl-thioester hydrolase activity (Molecular Function)\tregulation of interleukin-11 secretion (regulation of cytokine secretion)\tFallopian Tube Abnormality (Anatomical Abnormality)\tAcetylmethadolum (M [Preparations])", + "output": "Fallopian Tube Abnormality (Anatomical Abnormality)" + }, + { + "input": "Definition: Blood Cell Count Ratio Measurement described as a relative measurement (ratio or percentage) of the immature neutrophils to leukocytes in a biological specimen.\nConcepts: Special Storage Conditions (Qualitative Concept)\tNEUTIMLE (Blood Cell Count Ratio Measurement)\tTemplate (Reference set attribute)\tPatients should be treated as if they were partners with the doctor, equal in power and status (Intellectual Product)\tOcclusion of ureter NOS (Disorder of ureter)", + "output": "NEUTIMLE (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: something described as providing vitamins and minerals based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis.\nConcepts: Wheelchair Ramps, Portable (Medical Device)\tSpray Container (Containers)\tmedical nutrition therapy supplement vitamin & mineral (Nutrition supplement therapy)\tNodular lymphoid hyperplasia of lung (Disease or Syndrome)\tupregulation of glycine secretion, neurotransmission (positive regulation of synaptic transmission, glycinergic)", + "output": "medical nutrition therapy supplement vitamin & mineral (Nutrition supplement therapy)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative and/or quantitative analyses of a sample of body fluids (e.g., serum) to determine the parathyroid hormone (PTH), the final product in the biosynthesis from a 115 amino acid peptide called pre-PTH. PTH is synthesized and secreted by the parathyroid glands; its secretion is primarily regulated by the level of free calcium in plasma or extracellular fluid.\nConcepts: Metastatic Gastrointestinal Stromal Tumor (Gastrointestinal Stromal Sarcoma)\tupregulation of inflammatory response to antigenic stimulus (Organism Function)\tIVD Test Reagent/Kits, Immunoassay, Bone Metabolism Hormone, Parathyroid Hormone (Medical Device)\tG(M2) Activator Protein (Amino Acid, Peptide, or Protein)\tdUMP metabolic process (pyrimidine deoxyribonucleotide metabolic process)", + "output": "IVD Test Reagent/Kits, Immunoassay, Bone Metabolism Hormone, Parathyroid Hormone (Medical Device)" + }, + { + "input": "Definition: hydrolase activity, acting on acid sulfur-sulfur bonds described as catalysis of the reaction: H(2)O + trithionate = H(+) + sulfate + thiosulfate.\nConcepts: Abnormal circulating osteocalcin level (Abnormal circulating hormone level)\ttrithionate thiosulfohydrolase activity (Molecular Function)\tDrainage - action (Therapeutic or Preventive Procedure)\trespiratory gaseous exchange by respiratory system (multicellular organismal process)\tMammographically Dense Breast (Finding)", + "output": "trithionate thiosulfohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a preparation of autologous T-lymphocytes that have been transduced with a lentiviral vector to express a T-cell receptor mimetic (TCRm) antibody synthesized by a proprietary phage display platform, targeting the immunogenetic human tumor-associated antigen (TAA) alpha-fetoprotein (AFP) complexed with human leukocyte antigen (HLA)-A*02 (HLA-A*02/AFP), with potential antineoplastic and immunomodulatory activities. Upon administration, the autologous anti-HLA-A*02/AFP TCRm-expressing T-cells ET140202 specifically recognize and selectively bind to AFP peptides presented by HLA-A*02. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of AFP-expressing tumor cells. AFP, an intracellularly expressed fetal glycoprotein rarely expressed in adult tissues, is overexpressed in certain tumors of endodermal origin and plays a key role in tumor cell proliferation and survival. AFP is processed into peptides and presented by class I major histocompatibility complexes (MHCs) on the surface of tumor cells.\nConcepts: Actual (General Qualifier)\tcarotenoid vesicle (Cytoplasmic Vesicles)\tNeoantigen-Positive (Positive Laboratory Test Result)\tET-140202 (Antineoplastic Immune Cell)\tStoneroot (Collinsonia)", + "output": "ET-140202 (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: Non-site specific injuries NEC described as any injury that arises during participation in sports; most are not actually specific to sports.\nConcepts: TFIIIC 90 kDa Subunit (Transcription Factors, General)\tExpanded Access Study Protocol Intervention Or Procedure (Intellectual Product)\tATHLETIC INJ (Wellness and Lifestyle)\tREITERS DIS (Postinfective and reactive arthropathies)\tAdenocarcinoma of Anogenital Mammary-Like Glands (Neoplastic Process)", + "output": "ATHLETIC INJ (Wellness and Lifestyle)" + }, + { + "input": "Definition: something described as an mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.\nConcepts: hippocampal neuron apoptotic process (Apoptosis of neurons)\tLabial Artery (Arteries)\tartery morphogenesis (Organ or Tissue Function)\tREMETHOD (Laboratory Procedure)\tmitochondrial editosome (Cell Component)", + "output": "mitochondrial editosome (Cell Component)" + }, + { + "input": "Definition: Organic Chemical described as polycyclic compounds consisting of a furan ring fused with coumarin. They commonly occur in PLANTS, especially UMBELLIFERAE and RUTACEAE, as well as PSORALEA.\nConcepts: DOC-2 (Gene or Genome)\tCoronary valve (Structure of cardiac vein)\tYou should make your decision about which kind of treatment within 6 months, or the cancer can spread beyond cure (Intellectual Product)\tLearning to write (Mental Process)\tFurocoumarin (Dyes)", + "output": "Furocoumarin (Dyes)" + }, + { + "input": "Definition: Intellectual Product described as a subjective response indicating something was worse than expected.\nConcepts: Worse than I expected (Clinical or Research Assessment Answer)\tstudy publication date (Date in time)\tSinus prostaticus (Segment of prostatic urethra)\tIPSS-R Risk Category Intermediate (Finding)\tRibosomal RNA-1 (Biologically Active Substance)", + "output": "Worse than I expected (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Lymphangiectasis, Intestinal described as an acquired from of intestinal lymphangiectasia manifesting as a protein-losing enteropathy due to another disorder such as Crohn's disease, congestive heart failure, sarcoidosis, Turner syndrome and often in patients who have undergone a Fontan operation. It is characterised by malabsorption, diarrhoea, oedema due hypoproteinaemia, steatorrhoea and serosal effusions.\nConcepts: p21 CDC42/RAC1-ACTIVATED KINASE 1 (Serine/Threonine Protein Kinase Gene)\timmune globulin IV (immunoglobulin G)\tanti-CD157 monoclonal antibody MEN1112 (Amino Acid, Peptide, or Protein)\tSecondary intestinal lymphangiectasia (Lymphangiectasis, Intestinal)\tRISK INDICATORS (GENERAL PROBLEMS AND COMPLAINTS)", + "output": "Secondary intestinal lymphangiectasia (Lymphangiectasis, Intestinal)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as 7,8-dihydro-8-oxoguanine triphosphatase (197 aa, ~23 kDa) is encoded by the human NUDT1 gene. This protein is involved in the metabolism of both dGTP and DNA.\nConcepts: 2-Hydroxy-dATP Diphosphatase (Amino Acid, Peptide, or Protein)\tFAMS01-I Am Able to Enjoy Life (Intellectual Product)\tCystic leucoencephalopathy without megalencephaly (Congenital anomaly of cerebrum)\tCystic Neoplasm (Neoplasm by Special Category)\tHAIRINESS (Disease or Syndrome)", + "output": "2-Hydroxy-dATP Diphosphatase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Numerical Chromosomal Abnormality described as a chromosomal abnormality in which a near-haploid cell line is masked by a co-existing hyperdiploid line.\nConcepts: Piere-Robin syndrome (Multisystem disorder O-P)\tStage II Esophageal Adenocarcinoma (Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage)\tHypopharyngeal Cancer pT4b TNM Finding v6 (Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v6)\tGERM CELL DEGENERATION (biologic degeneration)\tMasked Near-Haploidy (Numerical Chromosomal Abnormality)", + "output": "Masked Near-Haploidy (Numerical Chromosomal Abnormality)" + }, + { + "input": "Definition: cellular aldehyde metabolic process described as the chemical reactions and pathways involving chanoclavine-I aldehyde.\nConcepts: Shelters, Emergency (Manufactured Object)\tMelanoma of the Skin pN1 TNM Finding v8 (Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v8)\tchanoclavine-I aldehyde metabolic process (Molecular Function)\tthylakoid lumen (cellular anatomical entity)\tmacromolecule (Chemical Viewed Structurally)", + "output": "chanoclavine-I aldehyde metabolic process (Molecular Function)" + }, + { + "input": "Definition: Central Nervous System Agents described as group of agents used as alcoholism deterrents, either by causing unpleasant symptoms when ethanol is ingested or as aids in withdrawal or maintenance of abstinence.\nConcepts: alcohol deterrents (alcohol relapse prevention agents)\tpontine reticular nucleus (Body Part, Organ, or Organ Component)\tIVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG, AFF2 Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Disorder, Trinucleotide Repeats, CGG)\tSubject Visit Start Day (Observation Start Day)\tfluoro-ara-AMP (Ribonucleotide Reductase Inhibitor)", + "output": "alcohol deterrents (alcohol relapse prevention agents)" + }, + { + "input": "Definition: something described as an inherited condition characterized by the development of kidney oncocytomas which are often bilateral and multifocal. This condition may be connected to Birt-Hogg-Dube syndrome.\nConcepts: Testicular Cancer pT1 TNM Finding v7 (Finding)\tEPIPHYSEAL DYSPLASIA, MULTIPLE, WITH EARLY-ONSET DIABETES MELLITUS (Syndrome)\tExtremity Gait (Clinical or Research Assessment Question)\tp-Hydroxynorephedrine (phenylpropanolamine)\tFamilial Renal Oncocytoma (Neoplastic Process)", + "output": "Familial Renal Oncocytoma (Neoplastic Process)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: (6E)-8-hydroxygeranial + NADP <=> (6E)-8-oxogeranial + NADPH + H+.\nConcepts: GSHPX-GI (GPX2 gene)\tB-RAF Inhibitor (Protein Kinase Inhibitors)\twitnesses (Adjudication)\t10-hydroxygeranial oxidoreductase activity (Molecular Function)\tSclerosing Thymoma (Thymoma)", + "output": "10-hydroxygeranial oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as mice homozygous for the mutant autosomal recessive gene, quaking (qk), associated with disorder in myelin formation and manifested by axial tremors.\nConcepts: Quaking Mice (Mice, Mutant Strains)\tOABQ01-Decrease Your Physical Activities (OAB-q Questionnaire Question)\tchloroplast outer membrane (chloroplast membrane)\tprotein kinase C activation (Molecular Function)\tPicomole per Liter per Milligram (Quantitative Concept)", + "output": "Quaking Mice (Mice, Mutant Strains)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a protein cleavage reagent comprised of the serine proteinase trypsin/P that cleaves proteins into peptides at the C-terminal side of a lysine or arginine residue.\nConcepts: Grade 3 Gallbladder Pain, CTCAE (Gallbladder Pain, CTCAE 5.0)\tEpilepsy, unspecified (Neurological Disorders)\tTrypsin/P Protein Cleavage Reagent (Protein Cleavage Reagent)\tlacking motivation (Behavioral/psychiatric manifestations)\tToo much calcium deposited in kidneys (kidney morphologic)", + "output": "Trypsin/P Protein Cleavage Reagent (Protein Cleavage Reagent)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Adult - In the past 7 days, how much of a problem has this been for you: My back feels stiff.\nConcepts: Grade 1 Stoma site infection (Stoma Site Infection, CTCAE)\tBiospecimen Pre-analytical Variables (Cancer Research)\tPQL1006 (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report Questionnaire Question)\tred light photoreceptor activity (Molecular Function)\tAyurvedic shaman fasting each 10 minutes (Medicine, Ayurvedic)", + "output": "PQL1006 (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report Questionnaire Question)" + }, + { + "input": "Definition: something described as instruments designed for the manual mechanical crushing of renal stones (calculi) in the urinary tract and/or bladder. These devices are typically consist handheld manual instruments with a distal end appropriate for grasping and crushing the stones and an attached handle designed to manipulate the instrument and apply the manual force needed to crush the stone. Lithotrites are used, frequently through the working channel of a cystoscope, to crush renal stones until the fragments are small enough to be extracted using irrigation and suctioning devices.\nConcepts: Dyspareunia, NOS (Female Reproductive System Disorder)\tLupus erythematosus, discoid (Lupus erythematosus and associated conditions)\tExercise tolerance functions, unspecified (Clinical Attribute)\tIL-3 receptor complex location (Cell Component)\tLithotrites (Medical Device)", + "output": "Lithotrites (Medical Device)" + }, + { + "input": "Definition: DNA repair protein described as nibrin (754 aa, ~85 kDa) is encoded by the human NBN gene. This protein is involved in cell cycle checkpoint control, DNA damage responses and meiotic recombination.\nConcepts: integrin alpha7-beta1 complex (integrin complex)\tNibrin (Biologically Active Substance)\tFreezers, Laboratory, Flammable Material (Laboratory freezer)\tChunking (cognitive processes)\tStatisticalAnalysisPlanVersionStatus (Status)", + "output": "Nibrin (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a respiratory tract route that begins within the nasal or periorbital sinuses.\nConcepts: Knowledge: Weight Management (Finding)\tafter image (Ocular Physiological Phenomena)\tSomeone to take you to the doctor if you needed it (Intellectual Product)\tI-SINAL (Drug Administration Routes)\tRisk Control: Environmental Hazards (Risk control behavior)", + "output": "I-SINAL (Drug Administration Routes)" + }, + { + "input": "Definition: Gene or Genome described as the human ETS2 wild-type allele is located in the vicinity of 21q22 and is approximately 19 kb in length. This allele, which encodes protein C-ets-2, is involved in the modulation of transcription by RNA polymerase II.\nConcepts: regulation of skeletal muscle contraction (Organism Function)\tETS2 wt Allele (ETS2 gene)\tPeriampullary adenocarcinoma (Adenocarcinoma of duodenum)\tKnobloch syndrome, type 1 (Gene or Genome)\tTargetoid Lesion (Lesion)", + "output": "ETS2 wt Allele (ETS2 gene)" + }, + { + "input": "Definition: something described as a system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.\nConcepts: Trial Tm Training Matl (Study Material)\thernia; umbilical, with gangrene (Gastrointestinal necrosis and vascular insufficiency)\tLECTIN, C-TYPE, SUPERFAMILY MEMBER 11 (Immunoprotein Gene)\tbiosynthetic process of protein-protein cross-link via 2-imino-methionine 5-imidazolinone glycine (protein-chromophore linkage)\tmismatch repair (Genetic Function)", + "output": "mismatch repair (Genetic Function)" + }, + { + "input": "Definition: Organic Chemical described as synthetic or natural chemical compounds which resemble xanthine in structure and/or function.\nConcepts: xanthine analog (Purine analog-containing product)\tPractices, Professional (Occupational Activity)\tDeath by Alcohol Ingestion (Cause of Death)\tNon-specified minor surgical procedure reference code no charge (Health Care Activity)\tupregulation of monooxygenase activity (Molecular Function)", + "output": "xanthine analog (Purine analog-containing product)" + }, + { + "input": "Definition: Multiple Organ Syndromes NEC described as adverse drug effects associated with CHOLINERGIC ANTAGONISTS. Clinical features include TACHYCARDIA; HYPERTHERMIA; MYDRIASIS, dry skin and dry mucous membranes, decreased bowel sounds and urinary retention in peripheral anticholinergic syndrome; and HALLUCINATIONS; PSYCHOSES; SEIZURES; and COMA in central anticholinergic syndrome.\nConcepts: esterosome lumen (cytoplasmic vesicle lumen)\tATROPINE-LIKE SYNDROME (Parasympatholytics)\tActuation Spray Valve Device (Container Closure System)\tnucleic acid-protein covalent cross-linking (Molecular Function)\tthyroid tumors (Neoplasm of trunk)", + "output": "ATROPINE-LIKE SYNDROME (Parasympatholytics)" + }, + { + "input": "Definition: Cytologic atypia described as abnormal cells from the outer walls of the cervix (the lower, narrow end of the uterus). Abnormal squamous cells (thin, flat cells that look like fish scales) are found in a low number of Pap smears (a procedure used to detect cervical cancer) and may indicate infection with the human papillomavirus (HPV) or another infectious agent. The risk of developing cervical cancer is very low for patients with ASCUS without HPV infection.\nConcepts: feeling emotional (Sign or Symptom)\tSalivary glands--Diseases (Salivary Gland Diseases)\tregulation of B lymphocyte activation (Cell Function)\tatypical squamous cells of undetermined significance (Squamous cell atypia)\tSDTIGVER (Intellectual Product)", + "output": "atypical squamous cells of undetermined significance (Squamous cell atypia)" + }, + { + "input": "Definition: Protein phosphatase described as a eukayrotic protein serine-threonine phosphatase subtype that dephosphorylates a wide variety of cellular proteins. The enzyme is comprised of a catalytic subunit and regulatory subunit. Several isoforms of the protein phosphatase catalytic subunit exist due to the presence of multiple genes and the alternative splicing of their mRNAs. A large number of proteins have been shown to act as regulatory subunits for this enzyme. Many of the regulatory subunits have additional cellular functions.\nConcepts: DEVELOPMENTAL DIS SPEECH LANGUAGE (Disorder of speech and language development)\tProtein Phosphatase 1 (Protein phosphatase)\tFelt Like a Failure (Intellectual Product)\tmaternal specification of dorsoventral axis, oocyte, soma encoded (oocyte dorsal/ventral axis specification)\tastaxanthin metabolism (xanthophyll metabolic process)", + "output": "Protein Phosphatase 1 (Protein phosphatase)" + }, + { + "input": "Definition: something described as compounds that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host.\nConcepts: Hantaan and related viruses (Virus)\tArea infraradiata ventralis (Body Location or Region)\tFruit or Vegetable (Food)\tComplement Inhibitors (Immunosuppressive Agents)\tFibrotic muscularis propria (Anatomical Abnormality)", + "output": "Complement Inhibitors (Immunosuppressive Agents)" + }, + { + "input": "Definition: Medical Device described as optical filter allowing transmission of violet light\nConcepts: intracellular organelle (Organelles)\tPI3K c.3140A>G (PIK3CA Exon 20 Mutation)\tpomegranate-extract pill (Dietary Supplements)\tViolet optical filter of optical microscope (Optical filter)\tiron-molybdenum cofactor metabolic process (cofactor metabolic process)", + "output": "Violet optical filter of optical microscope (Optical filter)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-furoyl-CoA + A + H(2)O = 5-hydroxy-2-furoyl-CoA + AH(2) + H(+).\nConcepts: MDX-1411 (Amino Acid, Peptide, or Protein)\tGrade 1 Oral cavity pain (Oral Pain, CTCAE 5.0)\tSystem, Stomatognathic (Body System)\t2-furoyl-CoA:acceptor 5-oxidoreductase (Molecular Function)\tDRRI-2 - D: Search/Disarm Potential Enemy (Intellectual Product)", + "output": "2-furoyl-CoA:acceptor 5-oxidoreductase (Molecular Function)" + }, + { + "input": "Definition: Body Location or Region described as the posterior aspect of the stomach.\nConcepts: ornithine esterase activity (Molecular Function)\teukaryotic translation initiation factor 4F complex (protein-containing complex)\tPosterior surface of stomach (Anatomic Surface)\tGATA binding protein 4 (Transcription factor genes)\tFolate Receptor 1 (Adult) Gene (Gene or Genome)", + "output": "Posterior surface of stomach (Anatomic Surface)" + }, + { + "input": "Definition: something described as intrahepatic bile duct cancer with no evidence of primary tumor.\nConcepts: SSR-97225 (Pharmacologic Substance)\tZinc Chromate (Hazardous or Poisonous Substance)\tSecondary Cardiac Lymphoma (Lymphoma by Site)\tIntrahepatic Bile Duct Cancer pT0 TNM Finding v7 (Finding)\tN box binding (Genetic Function)", + "output": "Intrahepatic Bile Duct Cancer pT0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Allergen class described as a glycosidase that hydrolyzes a glucosylceramide to yield free ceramide plus glucose. Deficiency of this enzyme leads to abnormally high concentrations of glucosylceramide in the brain in GAUCHER DISEASE. EC 3.2.1.45.\nConcepts: Physical Examination Group Identifier (Group ID)\tGlucocerebroside beta-glucosidase (Inborn errors metabolism lysosomal)\tL-Glutamin (Alternative medicine agent)\tbeta-D-ribosyl-6-methylthiopurine (Purine antagonist)\tPerformedSubstanceAdministration.interruptionDuration (Interruption Duration)", + "output": "Glucocerebroside beta-glucosidase (Inborn errors metabolism lysosomal)" + }, + { + "input": "Definition: something described as the Overactive Bladder Questionnaire Short Form - Made you feel like there is something wrong with you?\nConcepts: GAMMA FC RECEPT (CD Antigens)\tOAB-q Short Form - Feel Like There is Something Wrong with You (OAB-q Short Form Questionnaire Question)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen - Long Time to Bathe or Shower (Intellectual Product)\tIFE- immunofixation electrophoresis (Immunology procedure)\tIncreased PIVKA-II (Finding)", + "output": "OAB-q Short Form - Feel Like There is Something Wrong with You (OAB-q Short Form Questionnaire Question)" + }, + { + "input": "Definition: something described as devices intended for use to remove cemented castings from the teeth. Typically, these devices consist of a hooked bar that is applied to the cervical margin of the casting retainer; the weight against the handle provides the lever action which dislodges the crown.\nConcepts: Thymic carcinoma (Mediastinal Diseases)\tADL01-Number Don't Know Responses (Intellectual Product)\tFIJ (Melanesian language)\tCrown/Inlay Removers (Medical Device)\tUndefined male-specific test narrative required (Laboratory Procedure)", + "output": "Crown/Inlay Removers (Medical Device)" + }, + { + "input": "Definition: Aggregatibacter aphrophilus described as any bacterial organism that can be assigned to the species Aggregatibacter aphrophilus and is penicillinase positive.\nConcepts: up-regulation of latent-TGF-beta1 activation (Molecular Function)\tTransventricular (Anatomy Qualifier)\tAGGREGATIBACTER APHROPHILUS, PENICILLINASE POSITIVE (Bacterium)\tPUL 1.2 - Elbow Contractures (PUL 1.2 Functional Test Question)\tI have a lot of plans (Intellectual Product)", + "output": "AGGREGATIBACTER APHROPHILUS, PENICILLINASE POSITIVE (Bacterium)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the nine paired arteries arising from the aorta that supply the intercostal spaces (area between the ribs).\nConcepts: intercostal artery (Chest wall artery)\t4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(241)-en-3beta-ol-4alpha-methyl oxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tCusp Flail Severity (Cardiovascular finding)\tSNS01-T Nanoparticles (Pharmacologic Substance)\ttricuspid valve morphogenesis (atrioventricular valve morphogenesis)", + "output": "intercostal artery (Chest wall artery)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Leukemia Version 4 - Emotional Well-Being: I feel nervous.\nConcepts: HAQ02 (Intellectual Product)\tFACT-LEU Version 4 - I Feel Nervous (FACT-LEU Version 4 Questionnaire Question)\tRNARADSN (Name)\tRINZF (ZBTB46 gene)\tDecibel (Unit of Sound Intensity)", + "output": "FACT-LEU Version 4 - I Feel Nervous (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as a hamartoma (a benign, focal malformation consisting of a disorganized mixture of cells and tissues) of the retina.\nConcepts: trehalose PTS transporter activity (trehalose transmembrane transporter activity)\tRetinal hamartoma (Eye)\tMARKER, PERIODONTIC (Medical Device)\tgrowth population (Population Dynamics)\tXDP degradation (purine ribonucleotide catabolic process)", + "output": "Retinal hamartoma (Eye)" + }, + { + "input": "Definition: Gene Therapy Agent described as a replication-defective, recombinant adenoviral vector encoding the wild-type human tumor-suppressor protein p53 gene with potential antineoplastic activity. Upon intratumoral administration, rAD-p53 binds to the coxsakie-and-adenovirus receptor (CAR) on tumor cells and enters cells selectively via receptor-mediated endocytosis, which may result in the overexpression of wild-type p53 intracellularly and p53-mediated tumor regression. In addition, this agent may stimulate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against tumor cells, may activate natural killer (NK) cells to exert antitumor 'bystander effects' and may downregulate the expression of various oncogenes. The p53 protein blocks tumor cell cycle progression and directly initiates apoptosis; the p53 gene, a tumor suppressor gene, is deleted or mutated in a significant number of cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C85485\" active clinical trials using this agent.\nConcepts: Hexachlorobenzene (chlorobenzene)\trAd/p53 (Gene Transfer or Gene Delivery Agent)\tNUP98-HOXD13 Fusion Gene (Fusion Gene)\tZIC (ZIC1 gene)\tBupivacaine-containing product (Amide Local Anesthetic)", + "output": "rAd/p53 (Gene Transfer or Gene Delivery Agent)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in melanosome transport.\nConcepts: Refractory Round Cell Liposarcoma (Round Cell Liposarcoma)\tU.V. SPECTROMETRY, THEOPHYLLINE (Medical Device)\tParotid Gland Mucoepidermoid Carcinoma (Mucoepidermoid carcinoma of salivary gland)\tStem Cell Transplantation (Introduction of substance by body site)\tln (Trafficking Protein Gene)", + "output": "ln (Trafficking Protein Gene)" + }, + { + "input": "Definition: something described as the covalent addition to a protein of Smt3, a ubiquitin-like protein.\nConcepts: MEN (multiple endocrine neoplasia) 4 syndrome (Multiple Endocrine Neoplasia)\tSmt3p-protein conjugation (protein modification by small protein conjugation)\tUnknown Primary Tumor pN0 TNM Finding v8 (Finding)\tChlorocebus aethiops (Cercopithecidae)\tmetoclopramide HCl (benzamide)", + "output": "Smt3p-protein conjugation (protein modification by small protein conjugation)" + }, + { + "input": "Definition: Maxillary Sinus Cancer Pathologic Regional Lymph Nodes TNM Finding v7 described as maxillary sinus cancer with no metastasis to regional lymph nodes.\nConcepts: Interleukin 16 wt Allele (Gene or Genome)\tMaxillary Sinus Cancer pN0 TNM Finding v6 (Maxillary Sinus Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tStudy Schematic (Component of Study Protocol)\tAUF1 (Gene or Genome)\tSubject Status Test Code (Test Code)", + "output": "Maxillary Sinus Cancer pN0 TNM Finding v6 (Maxillary Sinus Cancer Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: Lights, manufactured described as lights designed to provide radiation mainly in the 100 to 380 nm wavelength range on the area being examined. These ultraviolet (UV) lights typically consist of low-pressure mercury vapor tubes that emit radiations that are invisible to the naked eye; however, when they are emitted from an ultraviolet lamp and directed at the surface of the examined area they are often transformed into visible colors. Most UV examination lights include an optically ground and polished magnifier lens to provide a clearer viewing area. Ultraviolet examination lights are used for observing and diagnosing diseases and injuries to the skin and eye including detection of corneal scratches, foreign bodies, blocked tear ducts, head lice, and fungal and/or bacterial infections. They are used in medical offices, emergency rooms, and other healthcare facilities.\nConcepts: QLES1-Free of Visual Problems (Q-LES-Q Questionnaire Question)\tLights, Examination, Ultraviolet (Medical Device)\tPharyngeal Mucositis (Non-Neoplastic Pharyngeal Disorder)\tBreast Neoplasm, Miscellaneous (NCI CTEP SDC Breast Neoplasm Category Terminology)\tIneffective thermoregulation (Temperature-associated finding)", + "output": "Lights, Examination, Ultraviolet (Medical Device)" + }, + { + "input": "Definition: Cell Function described as the process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules.\nConcepts: Nasal Cavity and Paranasal Sinuses Carcinoma pNX TNM Finding v8 (Finding)\tcolobomata (Congenital Abnormality)\tMacular drusen (exudative macular degeneration)\tOvens, Dental, Endodontic Gutta Percha Point Obturator (Electromechanical Devices)\texogenous peptide antigen processing and presentation via MHC class I (antigen processing and presentation of exogenous peptide antigen)", + "output": "exogenous peptide antigen processing and presentation via MHC class I (antigen processing and presentation of exogenous peptide antigen)" + }, + { + "input": "Definition: Pharmacologic Substance described as a derivative of the Canarypox Virus, ALVAC can infect mammalian cells but it can't replicate. Thus, it produces a self-limiting infection which does not produce symptoms or harm the host. When carrying foreign genes it will cause transient expression of protein.\nConcepts: DOC - Deoxycorticosterone (Corticosteroid and corticosteroid derivative)\tcubic millimetre (Quantitative Concept)\t2 (1H))-quinolinone,6-(amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl)-4-(3-chlorophenyl)-1-methyl-,(+)- (Organic Chemical)\tZinc sulfate-containing product (Zinc Compounds)\tALVAC Vaccine (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "ALVAC Vaccine (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - Either in preparation for or during my deployment: I was exposed to fumes or exhaust from heaters or generators, including heaters in tents.\nConcepts: DNA, C Form (Nucleic Acid, Nucleoside, or Nucleotide)\tNumber of Para-aortic Lymph Nodes Positive for Tumor by IHC Staining Only (Numbers)\tupregulation of carotenoid synthesis (positive regulation of cellular biosynthetic process)\tparallel fiber to Purkinje cell synapse (Excitatory Synapse)\tDRRI1-F: Exposed to Fumes From Heaters (DRRI-2 Questionnaire Question)", + "output": "DRRI1-F: Exposed to Fumes From Heaters (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: something described as an order of extremely halophilic archaea, in the kingdom EURYARCHAEOTA. They occur ubiquitously in nature where the salt concentration is high, and are chemoorganotrophic, using amino acids or carbohydrates as a carbon source.\nConcepts: Have Autoimmune or Inflammatory Condition (Findings-Based Question)\tORDER HALOBACTERIALES (Halobacteria)\tPODCI2-Easy to Make Friends (PODCI Adolescent Parent-Reported Version Questionnaire Question)\t3-keto-5-aminohexanoate cleavage enzyme (Molecular Function)\tUndesired Sedation Score 1 (Intellectual Product)", + "output": "ORDER HALOBACTERIALES (Halobacteria)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify variants in the majority of genes known to be associated with muscular dystrophies, a collection of neuromuscular diseases characterized by progressive weakening and degeneration of skeletal muscles. Genetic variants at multiple loci have been associated with muscular dystrophies. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in the majority of muscular dystrophy-associated loci simultaneously.\nConcepts: Subgen:Primate immunodef virus (Genus: Lentivirus group)\tIVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy, Comprehensive (Medical Device)\tCecum Ulcer, CTCAE (Finding)\tgrape seed extract supplement (Protective Agents)\tMyeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 1 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "IVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy, Comprehensive (Medical Device)" + }, + { + "input": "Definition: Implants described as a small device used to correct a heartbeat that is abnormal (too fast, too slow, or irregular). The device is placed by surgery in the chest or abdomen. Wires are passed through a vein to connect the device to the heart. When it detects abnormal heartbeats, it sends an electrical shock to the heart to restore the heartbeat to normal.\nConcepts: n (Anatomic landmark of head)\tCardioverter Defibrillator, Implantable (Automatic cardiac defibrillator)\tmL/ug/day (Unit of Dose Calculation)\ttube morphogenesis (Organism Function)\tDefined Activity Name Code (Intellectual Product)", + "output": "Cardioverter Defibrillator, Implantable (Automatic cardiac defibrillator)" + }, + { + "input": "Definition: guanine deglycation described as the removal of methylglyoxal from a glycated guanine, to form lactate and a deglycated guanine.\nConcepts: oculocardiac reflex (Organ or Tissue Function)\tHypothyroidism, Primary (Disease or Syndrome)\tWD7-How Many Days Difficulties Present (Intellectual Product)\touter dense plaque of desmosome (cellular anatomical entity)\tguanine deglycation, methylglyoxal removal (Molecular Function)", + "output": "guanine deglycation, methylglyoxal removal (Molecular Function)" + }, + { + "input": "Definition: something described as the methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine.\nConcepts: Ventilation, Intermittent Positive-Pressure (Positive-Pressure Respiration)\tScatter Artifact (CT Image Artifact)\tN-terminal peptidyl-methionine methylation (Molecular Function)\tadenine nucleotide transmembrane transporter activity (purine nucleotide transmembrane transporter activity)\tDry Heat Sterilization (Sterilization for infection control)", + "output": "N-terminal peptidyl-methionine methylation (Molecular Function)" + }, + { + "input": "Definition: Meningioma, benign, no ICD-O subtype described as a WHO grade I meningioma characterized by the presence of epithelial differentiation and numerous intracellular PAS positive bodies that are rich in glycogen.\nConcepts: PHENOXYBENZAMINE HYDROCHLORIDE (Nonspecific alpha-adrenergic blocking agent, NOS)\tSOLUTION, FORMOL CALCIUM (Indicator, Reagent, or Diagnostic Aid)\tupregulation of G quadruplex DNA binding (positive regulation of DNA binding)\tSecretory meningioma (Meningioma)\tC9, Complement (Immunologic Factor)", + "output": "Secretory meningioma (Meningioma)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities.\nConcepts: downregulation of tetrapyrrole formation from glutamate (negative regulation of tetrapyrrole biosynthetic process)\tStage II Supradiaphragmatic Hodgkin's Lymphoma (Neoplastic Process)\tArthus Reaction (Immune complex urticaria)\tFISH test (In Situ Hybridization)\tprostaglandin metabolic process (Molecular Function)", + "output": "prostaglandin metabolic process (Molecular Function)" + }, + { + "input": "Definition: Cell Cycle Proteins described as interferon-inducible protein AIM2 (343 aa, ~39 kDa) is encoded by the human AIM2 gene. This protein may be involved in apoptosis, inflammation and tumor suppression.\nConcepts: chromosome 19 (Chromosomes, Human)\tAbsent in Melanoma 2 (Biologically Active Substance)\tcellular response to polyamines (Cell Function)\tLymphoid Enhancer-Binding Factor 1 (Immunologic Factor)\tstriated muscle cell proliferation (muscle cell proliferation)", + "output": "Absent in Melanoma 2 (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a question associated with the VFQ25-Self Administered Format questionnaire.\nConcepts: regulation of synaptic vesicle neurotransmitter loading (Cell Function)\tRotors, Centrifuge (Laboratory instruments and equipment)\tVFQ25-Self Administered Format Questionnaire Question (Intellectual Product)\tMetyrapone-containing product (M [Preparations])\tIntravenous administration tubing extension set (Device Labeled for Single Use)", + "output": "VFQ25-Self Administered Format Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: Paranasal Sinus Neoplasms described as tumors or cancer of the MAXILLARY SINUS. They represent the majority of paranasal neoplasms.\nConcepts: Recombinant dHER2 Vaccine (Cancer Vaccines)\tMetanephrine Secreting (Hormonal Change)\tbiopsy of salivary gland (Respiratory tract evaluation)\tMUC6 (Amino Acid, Peptide, or Protein)\tMaxillary Antrum Tumor (Neoplasms)", + "output": "Maxillary Antrum Tumor (Neoplasms)" + }, + { + "input": "Definition: Approach Anatomic Site Laterality Code described as a coded value specifying the side of the body (or a paired organ) that is an access point for a procedure. EXAMPLE(S): bilateral, left, right OTHER NAME(S): NOTE(S): This attribute was deprecated in BRIDG 3.1 but undeprecated in 4.0 since source use cases for separate laterality include SDTM and CTOM. This change ensures that users of the BRIDG model are not bound to a particular kind of vocabulary, such as pre- or post-coordinated vocabularies. Collapsing laterality into the target site code is an implementation option.\nConcepts: Performed Procedure Approach Anatomic Site Laterality Code (Intellectual Product)\tubiquitin-independent protein catabolic process via the multivesicular body sorting pathway (Molecular Function)\tSuprapubic Region (Entire subregion of abdomen)\t231-232 INSECTICIDES (Hazardous Substances)\tmin.ug/ml/(mg/g) (Measurement Unit Description)", + "output": "Performed Procedure Approach Anatomic Site Laterality Code (Intellectual Product)" + }, + { + "input": "Definition: Transfusion Reaction described as presence of free hemoglobin in the urine.\nConcepts: Asternia (Congenital Abnormality)\tOcclusion Body Matrix Proteins (Amino Acid, Peptide, or Protein)\tPerformed Procedure Step SOP Class UID (Identifier)\tgtpases (Enzyme)\themoglobinuria (Presence of drug - finding)", + "output": "hemoglobinuria (Presence of drug - finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the amino acids and their 3-D arrangement in constituting a protein.\nConcepts: Itchy palm (Finding)\tMOTPTREF (Temporal Concept)\tInsertion of staple (Reparative closure)\tHospital, District (Health Care Related Organization)\tprotein structure (Molecular Structure)", + "output": "protein structure (Molecular Structure)" + }, + { + "input": "Definition: something described as conjunctival melanoma with tumor of any size invading the central nervous system.\nConcepts: 7beta,17alpha-Dimethyltestosterone (Pharmacologic Substance)\tLoss of Function ATRX Gene Mutation (Cell or Molecular Dysfunction)\tSexual preference (Finding relating to sexuality and sexual activity)\tSevere Difficulty (Finding)\tConjunctival Melanoma pT4 TNM Finding v8 (Finding)", + "output": "Conjunctival Melanoma pT4 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Colorectal Version 4 - Physical Well-Being: Because of my physical condition, I have trouble meeting the needs of my family.\nConcepts: 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine aldehydohydrolase activity (ether hydrolase activity)\tGRG1 (Gene or Genome)\tPresent (Action)\tFACT-C Version 4 - Trouble Meeting Needs of Family (FACT-C Version 4 Questionnaire Question)\tCYP2A7 gene (Gene or Genome)", + "output": "FACT-C Version 4 - Trouble Meeting Needs of Family (FACT-C Version 4 Questionnaire Question)" + }, + { + "input": "Definition: protein domain specific binding described as interacting selectively and non-covalently with a phosphotyrosine-binding (PTB) domain of a protein.\nConcepts: hexose degradation to propan-2-ol (Molecular Function)\tMNSI126 (MNSI Questionnaire Question)\tCatheter introducer (catheter device)\tnegative regulation of mannan degradation (Cell Function)\tphosphotyrosine-interacting domain binding (Molecular Function)", + "output": "phosphotyrosine-interacting domain binding (Molecular Function)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Raoultella planticola.\nConcepts: Environmental Cell-Transmission Electron Microscope (Medical Device)\tKlebsiella planticola Bagley et al. 1982 (Bacterium)\tSinistrocardia, NOS (Abnormal spatial orientation of the cardiac segments)\tVulvar Cancer pN3 TNM Finding v7 (Finding)\tanti-Gram-negative bacterial polypeptide induction (Molecular Function)", + "output": "Klebsiella planticola Bagley et al. 1982 (Bacterium)" + }, + { + "input": "Definition: something described as a eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.\nConcepts: PODCI275 (Intellectual Product)\tchromosomal passenger complex location (microtubule associated complex)\tnegative regulation of mitochondrial RNA catabolic process (Molecular Function)\tGDS0117 (GDS Questionnaire Question)\tPhosphodiesterase Type 3 Inhibitors (Phosphodiesterase Inhibitors)", + "output": "chromosomal passenger complex location (microtubule associated complex)" + }, + { + "input": "Definition: Analyte described as linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.\nConcepts: MutLalpha complex binding (Molecular Function)\tGrade 4 Hypophysitis (Hypophysitis, CTCAE)\tHave Vaginal Discharge (Intellectual Product)\tProtein, NOS (Organic Chemicals)\tCongenital syphilis NOS (Neonatal disorder)", + "output": "Protein, NOS (Organic Chemicals)" + }, + { + "input": "Definition: something described as biologically active molecules which are covalently bound to the enzymes or binding proteins normally acting on them. Binding occurs due to activation of the label by ultraviolet light. These labels are used primarily to identify binding sites on proteins.\nConcepts: Labels, Photoaffinity (Affinity Labels)\tup regulation of protein complex disassembly (regulation of protein-containing complex disassembly)\tGalanin 3 Receptor (Amino Acid, Peptide, or Protein)\tMYH11 wt Allele (Gene or Genome)\tBarr chromatin body (Heterochromatin)", + "output": "Labels, Photoaffinity (Affinity Labels)" + }, + { + "input": "Definition: Medical Device described as nasal surgical hooks designed to temporarily secure nasal tissues by catching and/or pulling them during dissection and excision in plastic surgical procedures with minimal trauma. Nasal surgical hooks typically consist of handheld manual stainless steel instruments with a shank bent near the distal end (usually at angles from 135 to 180 degrees) and a sharp or blunt tip. Rhinoplasty surgical hooks usually include two prongs at the distal tip and are available in different sizes. They can be supplied with an angled shaft to utilize the strength in the hand and provide an effective grip. These hooks are commonly used in plastic surgery procedures for reshaping the nose (e.g., rhinoplasty).\nConcepts: Lined Canister (Canister, device)\tCSS0119A (Intellectual Product)\tHooks, Rhinoplastic (Hooks, Surgical, Nasal)\tRestart (Qualitative Concept)\tVerbal Learning (Academic Learning & Achievement)", + "output": "Hooks, Rhinoplastic (Hooks, Surgical, Nasal)" + }, + { + "input": "Definition: intracellular immature spore described as portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions.\nConcepts: endospore-forming forespore (Cell Component)\t(p-Aminobenzolsulfonyl)-2-amino-4-methylpyrimidin (Sulfonamides, topical)\tmechanical stress (Mechanical Phenomena)\tWD1S6 (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)\ttrichiura, Trichuris (Eukaryote)", + "output": "endospore-forming forespore (Cell Component)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of aflatoxin biosynthetic process.\nConcepts: MSQL102 (MSQOL-54 Questionnaire Question)\tCapital Letter (Qualitative Concept)\tup-regulation of aflatoxin formation (Molecular Function)\tIn remission, NOS (Thesaurus of Psychological Index Terms)\tDispersion for Infusion Dosage Form (Liquid Dosage Form)", + "output": "up-regulation of aflatoxin formation (Molecular Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2,4,4-trimethylpentanal + H2O = 2,4,4-trimethylpentanoate + 3 H+ + 2 e-.\nConcepts: Platelet Activating Factor Stabilization (Physiologic Function)\tGrade 1 Night Blindness, CTCAE (Finding)\t2,4,4-trimethylpentanal dehydrogenase activity (Molecular Function)\tPretreatment Period (Temporal Concept)\tInternal fetal rotation (Sign or Symptom)", + "output": "2,4,4-trimethylpentanal dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: Anatomical Abnormality described as the presence of a fistula affecting the rectum.\nConcepts: ZFP423 (Gene or Genome)\tAgent, Antimalarial (Drugs and Biologicals)\tRectal Fistula (Lesion of rectum)\tChromium Hexavalent Compound (Carcinogenic Metal)\tMeasured oral intake of liquid meal replacement in 24 hours (Quantitative Concept)", + "output": "Rectal Fistula (Lesion of rectum)" + }, + { + "input": "Definition: something described as a pregnancy involving three fetuses.\nConcepts: pregnancy triplet (Multiple Pregnancy)\tEEG: generalised low amplitude activity (Finding)\tLength of catheter (Length)\tphosphoribosylpyrophosphate synthase activity (diphosphotransferase activity)\t3 Times Per Year (Schedule Frequency)", + "output": "pregnancy triplet (Multiple Pregnancy)" + }, + { + "input": "Definition: RNA, Untranslated described as single-stranded RNA molecules that are expressed in animal cells and form complexes with Piwi proteins. They are involved in transcriptional gene silencing.\nConcepts: HYDRAZINE SULFATE (Nitrogen and nitrogen compound)\tPiwi-Interacting RNA (Nucleic Acid, Nucleoside, or Nucleotide)\tALLRED STAINING INTENSITY SCORE (Finding)\tNucleus pulvinaris medialis dorsalis (Body Part, Organ, or Organ Component)\tProlyl 4-Hydroxylase, Alpha Polypeptide II Gene (Oxidoreductase Gene)", + "output": "Piwi-Interacting RNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Organic Chemical described as a novel pyrrolopyrimidine derivative, and an orally available inhibitor of the serine/threonine protein kinase AKT (protein kinase B) with potential antineoplastic activity. AKT inhibitor AZD5363 binds to and inhibits all AKT isoforms. Inhibition of AKT prevents the phosphorylation of AKT substrates that mediate cellular processes, such as cell division, apoptosis, and glucose and fatty acid metabolism. A wide range of solid and hematological malignancies show dysregulated PI3K/AKT/mTOR signaling due to mutations in multiple signaling components. By targeting AKT, the key node in the PIK3/AKT signaling network, this agent may be used as monotherapy or combination therapy for a variety of human cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102564\" active clinical trials using this agent.\nConcepts: MIR222 Gene (MicroRNA Gene)\tHypertelorism hypospadias polysyndactyly syndrome (Congenital anomaly of digit)\tAlveolar cell type II (Lung)\tAtypical Breast Myoepitheliosis (Neoplastic Process)\tAkt inhibitor AZD5363 (Organic Chemical)", + "output": "Akt inhibitor AZD5363 (Organic Chemical)" + }, + { + "input": "Definition: Organism Function described as the process pertaining to the initial formation of a limb bud from unspecified parts. This process begins with the formation of a local condensation of mesenchyme cells within the prospective limb field, and ends when a limb bud is recognizable.\nConcepts: Percent of Prostate Cores Positive for Carcinoma (Finding)\tepilepsy generalized (Disease or Syndrome)\tAbnormality of the gastrointestinal tract (Anatomical Abnormality)\tlimb formation (anatomical structure formation involved in morphogenesis)\tvirus maturation (Cell Function)", + "output": "limb formation (anatomical structure formation involved in morphogenesis)" + }, + { + "input": "Definition: Surgical Procedure by Method described as a procedure for destroying tissue using an electrical current.\nConcepts: growth hormone secreting cell differentiation (Cell Differentiation process)\tPanIN (Borderline Exocrine Pancreatic Neoplasm)\tELECTROCOAG (Cauterization - action)\tregulation of transcription, start site selection (regulation of nucleobase-containing compound metabolic process)\tCOMM1-Borrowed Meds From Others (COMM Questionnaire Question)", + "output": "ELECTROCOAG (Cauterization - action)" + }, + { + "input": "Definition: Intellectual Product described as a collection of agendas, presentation materials, and other documents generated for attendees during a safety report meeting.\nConcepts: Infant Abduction Prevention Systems (Intellectual Product)\tCyst, Popliteal (Soft tissue lesion of knee region)\tAdenocarcinoma in-situ (Carcinoma in Situ)\tSafe Mtng Matl (Intellectual Product)\tTorsade de pointes with short coupling interval syndrome (Torsades de Pointes)", + "output": "Safe Mtng Matl (Intellectual Product)" + }, + { + "input": "Definition: Peripheral vasoconstriction, necrosis and vascular insufficiency described as a rare condition characterized by skin inflammation, blister formation, swelling and ulcerations in the extremities. It occurs in persons exposed to cold temperatures.\nConcepts: Mis4-Ssl3 cohesin loading complex location (Cell Component)\tDizzy Frequency (Clinical or Research Assessment Question)\tchilblain (Other effects of reduced temperature)\tMoraxella, NOS (Aerobic Gram Negative Bacillus)\tmulticellular organism development (Organ or Tissue Function)", + "output": "chilblain (Other effects of reduced temperature)" + }, + { + "input": "Definition: something described as symbol Digit Modalities Test test code.\nConcepts: new 60min inofc ntrn ntak (Health Care Activity)\tSealyham Terrier (Dog family)\tpyridoxamineu-pyruvic transaminase activity (Molecular Function)\tCHRM3 Gene (Gene or Genome)\tCDISC Functional Test SDMT Test Code Terminology (Intellectual Product)", + "output": "CDISC Functional Test SDMT Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: something described as video image processors designed to convert video formats (e.g., PAL and NTSC; high-resolution RGB signals played back on low-resolution RGB monitors/projectors; low resolution RGB signals played back on high-resolution RGB monitors/projectors). These devices typically consist of electronic units with capabilities that include automatic input signal recognition, upward and downward conversions, scan line doubling, and other characteristics that improve image quality. Format conversion video image processors are intended to facilitate the operation of multiformat video environments existing in healthcare facilities.\nConcepts: Video Image Processors, Format Conversion (Video image processor)\tUbiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) Gene (UBE2S gene)\tsulphur amino acid biosynthesis (Molecular Function)\tPostmenopausal with no Prior Oophorectomy Status (Intellectual Product)\tSPEN Homolog (Biologically Active Substance)", + "output": "Video Image Processors, Format Conversion (Video image processor)" + }, + { + "input": "Definition: Electrodes, Blood Gas described as electrodes used in the chemical analysis of the blood for the concentration of oxygen. The electrode usually consists of a platinum wire or dropping mercury; oxygen concentration in blood samples is measured by polarography.\nConcepts: Abnormal cricoid cartilage morphology (Anatomical Abnormality)\tregulation of defence response to bacteria (regulation of response to external stimulus)\tElectrodes, Blood Gas, Oxygen (Medical Device)\tProtection Garments, Environmental, Decontamination/Cleaning (Medical Device)\tMicroscopes, Scanning Laser (Microscopes)", + "output": "Electrodes, Blood Gas, Oxygen (Medical Device)" + }, + { + "input": "Definition: Mitosis Modulators described as agents that arrest cells in MITOSIS, most notably TUBULIN MODULATORS.\nConcepts: Electronic Amplifiers (Electronics discipline)\tLithium Iodide Battery (Manufactured Object)\tMyb complex (protein-containing complex)\tUric acid (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tProduct containing mitotic inhibitor (Mitosis Modulators)", + "output": "Product containing mitotic inhibitor (Mitosis Modulators)" + }, + { + "input": "Definition: something described as the study of the chemistry, actions, and effects of drugs on living organisms or tissues. Used for intended effects of drugs; for adverse or undesired effects of drugs, use SIDE EFFECTS (DRUG). For the use of drugs in a treatment capacity, use DRUG THERAPY.\nConcepts: heredity (genetics and heredity)\tuL/ug/day (Unit of Dose Calculation)\tPharmacological (Biomedicine)\tNumber areic (Property)\t89Zr-DFO-cRGDY-PEG-Cy5-C' Dots (Radioimmunoconjugates)", + "output": "Pharmacological (Biomedicine)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+).\nConcepts: PNEUMOTACHOMETER (Medical Device)\tPARANOID SCHIZOPHRENIA (Schizophrenia)\tP2Y5 nucleotide receptor binding (Molecular Function)\tD-arabinose-5-phosphate ketol-isomerase activity (Molecular Function)\tnuc ish(13q14x1)[60]/(13q14x2)[40] (Finding)", + "output": "D-arabinose-5-phosphate ketol-isomerase activity (Molecular Function)" + }, + { + "input": "Definition: something described as alcohol Use Disorder Identification Test Self-Report Version (AUDIT) How often during the last year have you been unable to remember what happened the night before because of your drinking?\nConcepts: C11-PiB (Organic Chemical)\tKeratinizing Head and Neck Squamous Cell Carcinoma (Neoplastic Process)\tAcute myeloid leukaemia with inv(3)(q21q26.2) or t(3;3)(q21;q26.2); RPN1-EVI1 (Acute myeloid leukemia with recurrent genetic abnormality)\tADT0108 (Intellectual Product)\tToremifene Citrate Regimen (Therapeutic or Preventive Procedure)", + "output": "ADT0108 (Intellectual Product)" + }, + { + "input": "Definition: something described as anatomical fissure of eyeball, each instance of which is some groove at the junction of some sclera and cornea.\nConcepts: Hand Immobilizer (Manufactured Object)\tGrade 3 Varices (esophageal) hemorrhage (Esophageal Varices Hemorrhage, CTCAE 3.0)\tGrade 5 Neonatal Bradyarrhythmia (Neonatal Bradyarrhythmia, Adverse Event)\tStage IV Cervical Cancer AJCC v6 and v7 (Neoplastic Process)\tScleral sulcus (Body Location or Region)", + "output": "Scleral sulcus (Body Location or Region)" + }, + { + "input": "Definition: Gene or Genome described as human ILDR2 wild-type allele is located in the vicinity of 1q24.1 and is approximately 93 kb in length. This allele, which encodes immunoglobulin-like domain-containing receptor 2 protein, may be involved in immunomodulation, Notch signaling, the response to glucose and cellular homeostasis. Overexpression of the gene may be associated with increased susceptibility for type 2 diabetes.\nConcepts: Non-Neoplastic Brain Disorder (Brain Diseases)\tobsolete cell part (Cell Component)\t2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone (Organic Chemical)\tILDR2 wt Allele (Gene or Genome)\tAcupuncture (Biomedical Occupation or Discipline)", + "output": "ILDR2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Specimen Collection, Preparation and Reporting Procedures described as any procedure that involves testing or manipulating a sample of blood, urine, or other body substance in a laboratory setting.\nConcepts: General laboratory procedure, NOS (Knowledge: Preterm Infant Care)\tBothered a little (Clinical or Research Assessment Answer)\tlicartin (Pharmacologic Substance)\tBroadsides as Topic (Intellectual Product)\tUmbilical Cord Blood Stem Cell (Stem cells)", + "output": "General laboratory procedure, NOS (Knowledge: Preterm Infant Care)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as the effect that a cardiac rhythm device malfunction had on the ability to stimulate the heart.\nConcepts: CDISC SDTM Cardiac Rhythm Device Failure Manifestation Terminology (Intellectual Product)\tregulation of phagosome maturation (regulation of organelle organization)\tCall (Instruction Imperative)\tColorectal Neuroendocrine Tumor pT3 TNM Finding v8 (Finding)\tCSS0104A (Intellectual Product)", + "output": "CDISC SDTM Cardiac Rhythm Device Failure Manifestation Terminology (Intellectual Product)" + }, + { + "input": "Definition: Hospital furniture described as a patient conveyance device consisting of a platform (e.g., a sheet of canvas, a coach) supported by a framework on which an individual can be carried, usually in a supine or prone position. Stretchers are mostly used for transporting sick or injured persons. Mobile stretchers intended for use in health care facilities and ambulances as well as portable stretchers are available; stretchers designed to carry laboratory research animals are also available. Some stretchers are designed specifically for use in magnetic resonance imaging (MRI) environments (i.e., MRI-compatible stretchers) and are made from nonmagnetic materials so that they can be safely used in an MRI suite.\nConcepts: spen homolog, transcriptional regulator (Gene or Genome)\tsuppression by virus of host cytokine activity (suppression by virus of host molecular function)\tTHER ULTRASONIC (Physical agent therapy)\tstretcher (Hospital furniture)\tplastoglobuli (cellular anatomical entity)", + "output": "stretcher (Hospital furniture)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen.\nConcepts: Communities (Group)\tanaerobic benzoate metabolism (benzoate metabolic process)\tDextran 40 and 5% Albumin in Normal Saline (Agent Affecting Blood or Body Fluid)\trelaxation (Mind-Body Therapies)\tCountersinks (Medical Device)", + "output": "anaerobic benzoate metabolism (benzoate metabolic process)" + }, + { + "input": "Definition: something described as a role used to represent that another disease or disorder will only be observed in some cases of the specified disease. Both the domain and the range for this role are 'Disease, Disorder or Finding'.\nConcepts: Single Cell Analysis (Cytological Techniques)\tsite short name (Intellectual Product)\tLEFTB (Gene or Genome)\tIntervention Not Given for Kawasaki Disease (Other Finding)\tDisease May Have Associated Disease (Idea or Concept)", + "output": "Disease May Have Associated Disease (Idea or Concept)" + }, + { + "input": "Definition: CNS GENERAL described as a generalized tonic-clonic seizure.\nConcepts: Light Sources, Endoscope, Direct Attachment (Light Sources, Endoscope)\tIndigofera tinctoria / Indian maddar (Pharmacologic Substance)\tClonic-tonic convulsions (nervous system disorder)\tEmpyema, Pleural, Tuberculous (Disorder of pleura and pleural cavity)\tHobnail Variant Thyroid Gland Papillary Carcinoma (Neoplastic Process)", + "output": "Clonic-tonic convulsions (nervous system disorder)" + }, + { + "input": "Definition: Finding described as an indication or description that an event occurs concurrently with a substance overdose.\nConcepts: SOD (Result)\tGLNN (Gene or Genome)\tProduct containing amitriptyline (Tricyclic compound)\tPLL development (lateral line development)\t17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)- (Organic Chemical)", + "output": "SOD (Result)" + }, + { + "input": "Definition: something described as curved appearance of the distal phalanx of the 3rd finger.\nConcepts: Sodium Borocaptate (Inorganic Chemical)\tAtaxia-deafness syndrome X-linked (Auditory system hereditary disorder)\tCurved distal phalanx of the 3rd finger (Curved phalanges of the 3rd finger)\tSquare facies (Face)\tGMNCOC (Laboratory Procedure)", + "output": "Curved distal phalanx of the 3rd finger (Curved phalanges of the 3rd finger)" + }, + { + "input": "Definition: Pharmacologic Substance described as a potent, selective and orally bioavailable, cyanopyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.\nConcepts: Glasses, Eye (Ocular Prosthesis)\tAgree (Finding)\tGrade 4 Rectum perforation (Rectum Perforation, CTCAE 3)\tCD161a/Lymphocytes (Blood Cell Count Ratio Measurement)\t(2S,4S)-4-Fluoro-1-(2-(((1R,3S)-3-((1H-1,2,4-Triazol-1-yl)Methyl)Cyclopentyl)Amino)Acetyl)Pyrrolidine-2-Carbonitrile (Pharmacologic Substance)", + "output": "(2S,4S)-4-Fluoro-1-(2-(((1R,3S)-3-((1H-1,2,4-Triazol-1-yl)Methyl)Cyclopentyl)Amino)Acetyl)Pyrrolidine-2-Carbonitrile (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+).\nConcepts: recognition memory (Mental Processes)\torsellinate-depside hydrolase activity (Molecular Function)\tFunctions of orgasmic phase (Organism Function)\teukaryotic translation initiation factor 3 subunit E (Translation Process Gene)\taerosolized liposomal rubitecan (Topoisomerase I Inhibitors)", + "output": "orsellinate-depside hydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Placental finding described as three or more foci of two or more placental terminal villi showing karyorrhexis of fetal cells with preservation of the surrounding trophoblast. The villi may also show stromal hypercellularity and mineralization, and can either be hypovascular or only exhibit capillary degenerative changes. Entrapped red blood cells and red blood cell fragments are often seen.\nConcepts: Products and technology of suburban land development (Products and technology of land development)\tHemorrhagic Placental Endovasculitis (Placental finding)\tPEROXISOME BIOGENESIS DISORDER 7A (Disease or Syndrome)\tlaminaria/hai dai (Plant)\tDoxorubicin/Etoposide/Methotrexate Regimen (Regimen Used to Treat Small Cell Lung Carcinoma)", + "output": "Hemorrhagic Placental Endovasculitis (Placental finding)" + }, + { + "input": "Definition: Student Populations described as includes the middle and/or upper elementary school grades, usually grades 4, 5, and 6. Use ELEMENTARY SCHOOL STUDENTS unless specific reference is made to population as intermediate school students.\nConcepts: Connective tissue macrophage (macrophage)\tStage IVC Nasal Cavity and Paranasal Sinus Carcinoma AJCC v8 (Stage IV Nasal Cavity and Paranasal Sinus Cancer AJCC v8)\tIntermediate School Students (Population Group)\tPSD95 (DLG4 gene)\tSubdivision of front of trunk (Region of trunk)", + "output": "Intermediate School Students (Population Group)" + }, + { + "input": "Definition: Genetic Diseases, X-Linked described as this syndrome has characteristics of moderate intellectual deficit and precocious puberty. It has been described in three males from two generations of one Australian family. Morbid obesity was noted in the mothers of the patients. Transmission is X-linke\nConcepts: dreams (Thesaurus of Psychological Index Terms)\tBacterium pyocyaneum (Bacterium)\tVein Graft Holding Instruments, Surgical (Reusable Devices)\tFasciola (Trematoda)\tX-linked intellectual disability with precocious puberty and obesity syndrome (Hereditary disorder of endocrine system)", + "output": "X-linked intellectual disability with precocious puberty and obesity syndrome (Hereditary disorder of endocrine system)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: N(6)-dimethylallyladenine + S-adenosyl-L-methionine(1+) = S-methyl-5'-thioadenosine + discadenine + H(+).\nConcepts: SF36 v1.0 Standard Questionnaire Question (Clinical or Research Assessment Question)\tnodal receptor complex (Cell Component)\tIVD Test Reagent/Kits, Clinical Chemistry, Calibration, Cerebrospinal Fluid Test (IVD Test Reagent/Kits, Clinical Chemistry, Calibration)\tSample Study Population (Study Population)\tdiscadenine synthase activity (Molecular Function)", + "output": "discadenine synthase activity (Molecular Function)" + }, + { + "input": "Definition: something described as this gene plays a role in sulfate transport.\nConcepts: Grade 4 Urostomy stenosis (Urostomy Stenosis, CTCAE)\tdendritic cell dendrite (Cell Component)\tDRA (Ion Channel Protein Gene)\tStage I Carcinoma of the Urethra (stage, urethral cancer)\tOsteosarcoma, Metastatic (Sarcoma, metastatic)", + "output": "DRA (Ion Channel Protein Gene)" + }, + { + "input": "Definition: Sertoli-Leydig cell tumor of ovary described as a Sertoli-Leydig cell tumor characterized by the presence of spaces that resemble rete testis (retiform elements). These spaces form anastomosing patterns and comprise at least ten percent but less than ninety percent of the tumor. When the retiform elements comprise ninety percent or more of the tumor, the term retiform Sertoli-Leydig cell tumor is used. A minority of patients may have an aggressive clinical course.\nConcepts: Posterior spinal artery (Branch of posterior inferior cerebellar artery)\tBladder Carcinosarcoma (Neoplastic Process)\tgenetic counseling (Medical Genetics specialty)\tLeigh syndrome , French Canadian type (Leigh Disease)\tOvarian Sertoli-Leydig Cell Tumor with Retiform Elements (Sertoli-Leydig cell tumor of ovary)", + "output": "Ovarian Sertoli-Leydig Cell Tumor with Retiform Elements (Sertoli-Leydig cell tumor of ovary)" + }, + { + "input": "Definition: CCQ 24 Hour Version Questionnaire Question described as clinical COPD Questionnaire 24 Hour Version (CCQ 24 Hour Version) On average, during the past 24 hours, how often did you feel: Short of breath while doing physical activities?\nConcepts: CCQ0102 (CCQ 24 Hour Version Questionnaire Question)\tdebulking (Therapeutic or Preventive Procedure)\tOptic Atrophy Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Eye Disorder, Optic Atrophy)\tSyringes, Plunger, Arterial Blood Sampling, Luer Lock (Syringes, Plunger, Arterial Blood Sampling)\tICRUCUMAB (Anti-VEGFR Monoclonal Antibody)", + "output": "CCQ0102 (CCQ 24 Hour Version Questionnaire Question)" + }, + { + "input": "Definition: Other Organism Groupings described as organisms whose GENOME has been changed by a GENETIC ENGINEERING technique.\nConcepts: Abnormality of the palmar creases (Hand)\tnegative regulation of phenazine biosynthetic process (negative regulation of cellular biosynthetic process)\tc-erbB1 Amplification Analysis (Laboratory Procedure)\tModified Organism, Genetically (Plants)\tValve of coronary sinus (Coronary sinus structure)", + "output": "Modified Organism, Genetically (Plants)" + }, + { + "input": "Definition: Organic Chemical described as brand name of insecticide\nConcepts: MONITOR (Hazardous or Poisonous Substance)\t2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide cis-trans-isomerase activity (cis-trans isomerase activity)\tN-cyclopropylmelamine metabolic process (s-triazine compound metabolic process)\tAmazon Manatee (Mammal)\tMOTPT (Planned Time Point Name)", + "output": "MONITOR (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the premaxilla (the embryonic structure that forms the anterior part of the maxilla) causing it to appear relatively large in size compared to the other parts of the maxilla or other facial structures.\nConcepts: Submaxillary (Body part)\tmonoclonal immunoglobulin deposition disease (Neoplasm, uncertain whether benign or malignant)\tMycosis fungoides refractory (Mycosis Fungoides)\tparvalbumin (Amino Acid, Peptide, or Protein)\tIncreased size of the primary palate bone (Abnormality of the premaxilla)", + "output": "Increased size of the primary palate bone (Abnormality of the premaxilla)" + }, + { + "input": "Definition: Intellectual Product described as an ordered list of times at which things are planned to occur.\nConcepts: HDAC Inhibitor VRx-3996 (Pharmacologic Substance)\tHIST1 (H1-1 gene)\tSchedules (Intellectual Product)\tCampylobacter Jejuni Infection (Disease or Syndrome)\tPathogen Confirmation (Clinical or Research Assessment Question)", + "output": "Schedules (Intellectual Product)" + }, + { + "input": "Definition: Optic Nerve Glioma, Childhood described as an astrocytoma that arises from the visual pathway and occurs during childhood.\nConcepts: C-IV (Schedule of Controlled Substances)\tDermoid Cyst of the Orbit (Orbital cyst)\tPQL04-Wake Up Tired (Intellectual Product)\tChildhood Optic Tract Astrocytoma (Neoplastic Process)\td.umol/L/g (Quantitative Concept)", + "output": "Childhood Optic Tract Astrocytoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as an annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.\nConcepts: N Nitrosodimethylamine (Nitrosamines)\tsoya (Pulse vegetables)\tChiapas (Geographic Area)\tHDMP (Regimen Used to Treat Acute Lymphoblastic Leukemia)\t(15S)-15-Methyl-PGF2alpha (C [Preparations])", + "output": "soya (Pulse vegetables)" + }, + { + "input": "Definition: Level of fatigue described as pain in muscle.\nConcepts: Bromothymol Blue (thymol)\tPerceptual Masking (Auditory Perception)\tBaclofen-containing product (Allergen class)\tMUSCLE DISCOMFORT (neuromuscular, connective tissue, or soft tissue symptoms)\tCCQ01-Produce Sputum or Phlegm (Intellectual Product)", + "output": "MUSCLE DISCOMFORT (neuromuscular, connective tissue, or soft tissue symptoms)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving pyrrolysine, N6-{[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrol-2-yl]carbonyl}-L-lysine.\nConcepts: pyrrolysine metabolic process (cellular modified amino acid metabolic process)\tERBB2 Exon 20 Insertion Mutation (ERBB2 Exon 20 Mutation)\tcentimeter squared (SI-derived unit of area)\tsynthesis of RNA primer involved in cell cycle DNA replication (DNA replication, synthesis of RNA primer)\tGliosarcoma (gliosarcoma)", + "output": "pyrrolysine metabolic process (cellular modified amino acid metabolic process)" + }, + { + "input": "Definition: something described as polymers composed of galactose residues and occurring in plants, for example, agar.\nConcepts: ectodermal digestive tract morphogenesis (Organ or Tissue Function)\tPhysiologic monitoring system (Monitor Device)\t16: 30815429-30822382 (Spatial Concept)\tPolygalactoses (Organic Chemical)\tMitochondrial Anemia Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Mitochondrial Disorder, Anemia)", + "output": "Polygalactoses (Organic Chemical)" + }, + { + "input": "Definition: Finding described as retinoblastoma with no metastasis.\nConcepts: Kidney Injury Molecule-1 Excretion Rate (Quantitative Concept)\tNon-Neoplastic Vascular Disorder (Vascular Diseases)\tRetinoblastoma cM0 TNM Finding v7 (Finding)\ttranslocated promoter region (to activated MET oncogene) protein, human (Amino Acid, Peptide, or Protein)\tInsulinotropic Polypeptide Receptor, Glucose-Dependent Gene (Gene or Genome)", + "output": "Retinoblastoma cM0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as the completed action of determining the total number of an item in a project. EXAMPLE(S): The number of subjects that have completed the screening process in a study; the number of study sites that have received their site initiation visit. OTHER NAME(S): NOTE(S):\nConcepts: Performed Progress Count (Count)\tblunted affect (Behavioral/psychiatric manifestations)\tup regulation of satellite cell differentiation (Biologic Function)\tP450 omega-hydroxylase pathway (Molecular Function)\tcarotenes (Hydrocarbons)", + "output": "Performed Progress Count (Count)" + }, + { + "input": "Definition: something described as the opening of the ureter in the bladder that is situated at the lateral angle of the trigone.\nConcepts: ROR3 (RORA gene)\tOrifice of the Ureter (Neoplastic Process)\tAbnormal position of the lacrimal punctum (Abnormal lacrimal punctum morphology)\tHead and neck region (Topographic Regions and Cellular Structure)\tmyo-inositol-hexakisphosphate 5-phosphohydrolase activity (Molecular Function)", + "output": "Orifice of the Ureter (Neoplastic Process)" + }, + { + "input": "Definition: fowlpox virus vaccine described as a cancer vaccine comprised of a recombinant fowlpox virus vector encoding the melanoma antigen glycoprotein 100 (gp 100) with potential antineoplastic activity. The expression of gp100 may generate a cellular immune response to melanoma cells; this effect is enhanced by the co-administration of interleukin 2 (IL-2).\nConcepts: Gastrointestinal Stromal Tumor pM1 TNM Finding v8 (Gastrointestinal Stromal Tumor Pathologic Distant Metastasis TNM Finding v8)\tSRGRPID (Intellectual Product)\tgp100-fowlpox vaccine (Pharmacologic Substance)\tAorticopulmonary Septal Defect (Heart Septal Defects)\tFifth finger distal phalanx clinodactyly (Clinodactyly of the 5th finger)", + "output": "gp100-fowlpox vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: Organic Chemical described as pumpkin seed.\nConcepts: nonspecific NADPH-dependent carbonyl reductase activity (Molecular Function)\tcurcurbita pepo/pumpkin seed (Homeopathic remedies letter C)\tPERSISTENT PUPILLARY MEMBRANE (Congenital Abnormality)\tBLCS0101 (BLCS Questionnaire Question)\thallucinating (Delusions)", + "output": "curcurbita pepo/pumpkin seed (Homeopathic remedies letter C)" + }, + { + "input": "Definition: Device set described as a setting and safety feature on a device to control the maximum amount of a substance delivered in a single bolus.\nConcepts: Budd-Chiari Syndrome (Venous Thrombosis)\tMaximum Bolus (Functional Concept)\tInterstitial Route of Drug Administration (Drug Administration Routes)\tPK2 (PKM gene)\tMethanobrevibacter (Bacterium)", + "output": "Maximum Bolus (Functional Concept)" + }, + { + "input": "Definition: something described as a measurement of the Chlamydia pneumoniae IgA antibody in a biological specimen.\nConcepts: EGEVLINT (Temporal Concept)\tprostaglandin e1 pge1 (Organic Chemical)\t5-hydroxytryptamine 6 receptor binding (G protein-coupled serotonin receptor binding)\tguanosine salvage (guanosine biosynthetic process)\tChlamydia pneumoniae IgA Antibody Measurement (Laboratory Procedure)", + "output": "Chlamydia pneumoniae IgA Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Pathological fracture described as a pathologic fracture occurs when a bone breaks in an area that is weakened secondary to another disease process such as tumor, infection, and certain inherited bone disorders. A pathologic fracture can occur without a degree of trauma required to cause fracture in healthy bone.\nConcepts: GM2 lactone/GD2 lactone/GM3 lactone-KLH conjugate trivalent vaccine (Pharmacologic Substance)\tDIA/DIG - desmoplastic infantile astrocytoma/ganglioglioma (Low grade glioma of cerebrum)\tPathologic fracture (Limb structure)\tAbnormal pulmonary thoracic imaging finding (Finding)\tELISA/ACT(R) Screening Food Block 142 each test (Laboratory Procedure)", + "output": "Pathologic fracture (Limb structure)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify Mycoplasma pneumoniae, a species of bacterium of the genus Mycoplasma, family Mycoplasmataceae, by detecting specific genetic information of the ribosomal ribonucleic acid (rRNA) of the target bacteria. These bacteria are the etiologic agent of mycoplasmosis, primary atypical pneumonia (i.e., mycoplasmal pneumonia), and other febrile upper-respiratory-tract infections.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycoplasma pneumoniae, rRNA (Medical Device)\tcellular response to light stimulus (Cell Function)\thomocysteine anabolism (homocysteine metabolic process)\tNeurohormones (Hormones)\tSTIMULATOR, ELECTRICAL, IMPLANTABLE, FOR INCONTINENCE (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycoplasma pneumoniae, rRNA (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as alkaloid of cocaine.\nConcepts: Scanning Tunneling Microscopies (Atomic Resolution Microscopy)\tPancreatic Prohormone (Amino Acid, Peptide, or Protein)\tCalreticulin (Calcium-Binding Proteins)\tEdema of larynx (Pathologic Function)\tcocaine/cocaine alkaloid (Organic Chemical)", + "output": "cocaine/cocaine alkaloid (Organic Chemical)" + }, + { + "input": "Definition: Import into cell described as the directed movement of uracil from outside of a cell, across the plasma membrane and into the cytosol.\nConcepts: Immunocompatibility, Maternal-Fetal (Histocompatibility)\turacil import into cell (Cell Function)\tDocumentation of client/patient choice of alternate care no charge (Health Care Activity)\tBoNT/B8 (Hazardous or Poisonous Substance)\tneuron fate specification (cell fate specification)", + "output": "uracil import into cell (Cell Function)" + }, + { + "input": "Definition: something described as an electrocardiographic finding of relatively short duration QRS complexes that originate from the region of the posterior fascicle (or occasionally the anterior fascicle) of the left bundle branch.\nConcepts: Onset of complaint(s) following surgery (Medical History)\tFascicular Tachycardia by EKG Finding (Disease or Syndrome)\tphosphodiesterase E4 dunce homolog (Gene or Genome)\tPQL08-Hands Are Weak (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)\tsequoyitol galactinol:D-galactosylononitol galactosyltransferase activity (Molecular Function)", + "output": "Fascicular Tachycardia by EKG Finding (Disease or Syndrome)" + }, + { + "input": "Definition: Interferons described as a recombinant form of the natural Interferon beta that varies in the amino acid sequence and lacks the carbohydrate side chain. Clinical Use: Multiple Sclerosis.\nConcepts: Rey Auditory Verbal Learning Test Functional Test Test Code (Intellectual Product)\tMarsupial (Theria )\tMitochondrial Gene (Gene or Genome)\tCassavas (Manihoteae)\tSer(17) IFN-beta (Immunologic Factor)", + "output": "Ser(17) IFN-beta (Immunologic Factor)" + }, + { + "input": "Definition: Intellectual Product described as the terminology that includes concepts relevant to the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND) body weight test names.\nConcepts: BWTEST (CDISC SEND Terminology)\th.ng/ml/kg (Quantitative Concept)\tNursing Service Providers; Licensed Vocational Nurse (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tIntraoral Electrogalvanisms (Dentistry)\tVibrio septicus (Clostridium)", + "output": "BWTEST (CDISC SEND Terminology)" + }, + { + "input": "Definition: cell fate commitment described as the process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell.\nConcepts: stem cell fate commitment (Cell Function)\tIKAROS Family Zinc Finger 1 Protein 1 N159Y (Cell or Molecular Dysfunction)\tFDF (Manufactured form)\tComplete clearance; esophageal coating (Finding)\tpositive regulation of clotting (regulation of coagulation)", + "output": "stem cell fate commitment (Cell Function)" + }, + { + "input": "Definition: Rattus described as a strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).\nConcepts: Stage IVA Paranasal Sinus Cancer AJCC v7 (Neoplastic Process)\tsourceTypeCode (Intellectual Product)\tIntermediary Metabolism Disorder (Inborn Errors of Metabolism)\tRat, WKY (Rattus norvegicus)\tPORPHYROMONAS GINGIVALIS (Bacterium)", + "output": "Rat, WKY (Rattus norvegicus)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIIA includes: IIIA1: T1/2, N1, M0; IIIA2: T3a, N0/N1, M0. T1: Fallopian tube cancer with tumor limited to fallopian tube(s). T2: Fallopian tube cancer with tumor involving fallopian tubes with pelvic extension below pelvic brim. T3a: Fallopian tube cancer with microscopic extrapelvic (above the pelvic brim) peritoneal involvement with or without positive retroperitoneal lymph nodes. N0: No regional lymph node metastasis. N1: Positive retroperitoneal lymph nodes only (histologically confirmed). M0: No distant metastasis.\nConcepts: Grade 2 Nipple deformity (Nipple Deformity, CTCAE)\tPachygyria with cortical thickness > 10 mm anterior predominant (Thick pachygyria)\tHLA-DR Serological Subtypes (HLA-DR Antigens)\tBurkholderia cepacia Complex (Burkholderia)\tStage IIIA Fallopian Tube Carcinoma AJCC v8 (Neoplastic Process)", + "output": "Stage IIIA Fallopian Tube Carcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Time patterns described as accessory, accompanying especially in a subordinate or incidental way, occurring or existing during the same period of time.\nConcepts: simultaneously (Temporal Concept)\tMulticystic Mesothelioma of the Peritoneum (Benign neoplasm of peritoneum)\tcellular response to Thyroglobulin triiodothyronine (response to Thyroglobulin triiodothyronine)\tCDRS-R - Excessive Guilt (CDRS-R Clinical Classification Question)\tconsciousness states (Conscious)", + "output": "simultaneously (Temporal Concept)" + }, + { + "input": "Definition: Blood Coagulation Disorders described as a clotting condition characterized as a disruption in the homeostatic balance of the coagulation and fibrinolytic systems presenting as a pathological activation of coagulation mechanisms leading to the formation of small clots inside the blood vessels throughout the body of the newborn.\nConcepts: Set of internal thoracic veins (Intrathoracic systemic vein)\tMYCOBACT BURULI (Atypical mycobacteria species n-z)\tADL0211 (ADCS-ADL Severe Dementia Questionnaire Question)\tDisseminated intravascular coagulation of fetus and newborn (Neonatal hematologic disorder)\tPenile Mesenchymal Neoplasm (Penile Neoplasms)", + "output": "Disseminated intravascular coagulation of fetus and newborn (Neonatal hematologic disorder)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as an autosomal dominant form of hereditary motor and sensory neuropathy with dominant proximal involvement. Manifestations include adult-onset proximal neurogenic atrophy, sensory involvement, painful muscle cramps, fasciculations, areflexia, and high incidences of elevated creatine kinase levels, hyperlipidaemia, and diabetes mellitus.\nConcepts: HEREDITARY MOTOR AND SENSORY NEUROPATHY, PROXIMAL TYPE (Disease or Syndrome)\tCYP3A4, L293P (CYP3A4 gene)\tHave you gained weight (Clinical or Research Assessment Question)\tLead Placement Bicycle (Lead Placement)\tSF-36 v2.0 Acute - Question 4b (SF36 v2 0 Acute Questionnaire Question)", + "output": "HEREDITARY MOTOR AND SENSORY NEUROPATHY, PROXIMAL TYPE (Disease or Syndrome)" + }, + { + "input": "Definition: Basic Research described as 1B; Basic Science Research (includes vaccine and chemotherapy development), Neuroscience And Neuropsychiatric Research\nConcepts: Filament, Actin (Cytoskeleton)\tallogeneic transplantation (Organ Transplantation)\tNeuroscience and Neuropsychiatric Research (Research Activity)\tColorimetry (Spectrometry)\tMyocarditis, CTCAE 5.0 (Finding)", + "output": "Neuroscience and Neuropsychiatric Research (Research Activity)" + }, + { + "input": "Definition: Finding described as absence of the distal phalanx of the ring (4th) finger.\nConcepts: Hemodialysis Units, Renal, Intermittent (Medical Device)\tLarge nares (Finding of appearance of nose)\tAplasia of the distal phalanx of the 4th finger (Aplasia of the 4th finger)\tTissue/Specimen Collection (Health Care Related Organization)\tKLK3 protein, human (Amino Acid, Peptide, or Protein)", + "output": "Aplasia of the distal phalanx of the 4th finger (Aplasia of the 4th finger)" + }, + { + "input": "Definition: Central Nervous System described as atrophy of the cortex of the cerebrum.\nConcepts: Intimal dissection (Non-Neoplastic Vascular Disorder)\tGrade 2 Injury To Jugular Vein, CTCAE (Finding)\tOVARIAN CYST BENIGN (Neoplastic Process)\tCommissure, Forebrain (Body Part, Organ, or Organ Component)\tcortical; atrophy (Central Nervous System)", + "output": "cortical; atrophy (Central Nervous System)" + }, + { + "input": "Definition: antibiotic biosynthetic process described as the chemical reactions and pathways resulting in the formation of 2-deoxystreptamine.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Limit: Walking Up 5 Stairs (Intellectual Product)\tBullet-shaped bones of 3rd toe (Anatomical Abnormality)\tHand Digit 4 Distal Phalanx (Distal phalanx of hand)\t2-deoxystreptamine anabolism (antibiotic biosynthetic process)\tPedsQL Neuromuscular Module Version 3.0 Teen Report - Hard for Family to Plan Activities (PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question)", + "output": "2-deoxystreptamine anabolism (antibiotic biosynthetic process)" + }, + { + "input": "Definition: Peripheral Nervous System Part described as the division of the peripheral nervous system that comprises the afferent loop of the somatic nervous system, which functions to relay somatosensory perception, including touch, heat, and cold to the spinal cord and CNS.\nConcepts: Deformation Problem (Finding)\tSensory-Somatic Nervous System (Peripheral Nervous System Part)\tHypoplastic fibulae (Short long bone)\t9H-Purine, 6-(methylthio)-9-.beta.-D-ribofuranosyl- (Nucleic Acid, Nucleoside, or Nucleotide)\tatrophy multiple system (Pathologic Function)", + "output": "Sensory-Somatic Nervous System (Peripheral Nervous System Part)" + }, + { + "input": "Definition: Set of subarachnoid sulci described as a superficial feature of the lateral surface of the parietal lobe identified by dissection. In the human it is located caudal and parallel to the central sulcus, it is continuous in about half of cases and discontinuous with 2 or 3 segments in half. Dorsally it separates the postcentral gyrus from the superior parietal lobule, ventrally from the supramarginal gyrus of the inferior parietal lobule ( Ono-1990 ).\\r\\nIn the macaque it is a short sulcus located on the dorsolateral surface of the lobe, where it partially separates the postcentral gyrus from the superior parietal lobule ( Martin-2000 ). \\r\\nEquivalent features are not found in the smooth cerebral cortex of the rat or mouse ( NeuroNames ).\nConcepts: stage III pleural mesothelioma (Neoplastic Process)\tpocs (Cerebral sulcus)\tAllopathic & Osteopathic Physicians; Psychiatry & Neurology, Obesity Medicine (Professional or Occupational Group)\tDLQI1-Affected Social, Leisure Activity (DLQI Questionnaire Question)\tmodulation by symbiont of host systemic acquired resistance (Organism Function)", + "output": "pocs (Cerebral sulcus)" + }, + { + "input": "Definition: something described as a separation (dissection) of the layers of the external carotid artery wall.\nConcepts: Lidocaine Patch (Anesthetics)\tFerromagnetic Foreign Body Detectors (Medical Device)\tdissection of external carotid artery (Disease or Syndrome)\tNPI - Periods of Shortness of Breath, Gasping, or Sighing for No Apparent Reason (Intellectual Product)\tHAMD 24 - Hopelessness (Intellectual Product)", + "output": "dissection of external carotid artery (Disease or Syndrome)" + }, + { + "input": "Definition: RNA described as short chains of RNA (100-300 nucleotides long) that are abundant in the nucleus and usually complexed with proteins in small nuclear ribonucleoproteins; many function in the processing of messenger RNA precursors; others, the small nucleolar RNAs, are involved with the processing of ribosomal RNA precursors.\nConcepts: phosphatidylinositol phospholipase C activity (Molecular Function)\tSmall Nuclear RNA (RNA, Untranslated)\tcentral nervous system vasculitis (Autoimmune Diseases of the Nervous System)\t1H-Pyrrole-3-methanamine, 5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-, (2E)-2-Butenedioate (Cytoprotective agent)\tPneumatic Test Stands (Medical Device)", + "output": "Small Nuclear RNA (RNA, Untranslated)" + }, + { + "input": "Definition: Hemodynamics described as the measure of a BLOOD VESSEL's ability to increase the volume of BLOOD it holds without a large increase in BLOOD PRESSURE. The vascular capacitance is equal to the change in volume divided by the change in pressure.\nConcepts: synaptobrevin 2-SNAP-25-syntaxin-4 complex (Cell Component)\tKIAA0085 (Gene or Genome)\tgibberellin A4 carboxyl methyltransferase activity (methyltransferase activity)\theart muscle growth (Organ or Tissue Function)\tCapacitance, Vascular (Hemodynamics)", + "output": "Capacitance, Vascular (Hemodynamics)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.\nConcepts: retina development in camera-type eye (Organ or Tissue Function)\tCells, Veiled (Langerhans cell)\t2-octaprenyl-6-hydroxy phenol methylase activity (Molecular Function)\tIncreased anti-nut food product IgE antibody level (Increased anti-food allergen IgE antibody level)\tanterior polar ring of apical complex location (Cell Component)", + "output": "retina development in camera-type eye (Organ or Tissue Function)" + }, + { + "input": "Definition: Geographic Area described as the geographic area of the midwestern region of the United States in general or when the specific state or states are not indicated. The states usually included in this region are Illinois, Indiana, Iowa, Kansas, Kentucky, Michigan, Minnesota, Missouri, Nebraska, Ohio, Oklahoma, North Dakota, South Dakota and Wisconsin.\nConcepts: MENTHOL, UNSPECIFIED FORM (Drug allergens)\tMidwest US (United States)\tBile Duct, Intrahepatic (Biliary tract structure)\t3-(2-(Dimethylamino)ethyl)indole (Hypnotics, Sedatives and Psychotomimetic Agents)\tPancreatic insufficiency, dyserythropoietic anaemia, calvarial hyperostosis syndrome (Digestive system hereditary disorder)", + "output": "Midwest US (United States)" + }, + { + "input": "Definition: Regulatory Protein described as myelodysplastic syndrome 2 translocation-associated protein (140 aa, ~15 kDa) is encoded by the human MDS2 gene. This protein plays a role in myelodysplastic syndrome.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PEX7 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tNEF4 complex location (Cell Component)\tTNFR1-Associated Death Domain Protein (Death Domain Receptor Signaling Adaptor Proteins)\tMyelodysplastic Syndrome 2 Translocation-Associated Protein (Regulatory Protein)\t965 JUDGEMENT (Cognition)", + "output": "Myelodysplastic Syndrome 2 Translocation-Associated Protein (Regulatory Protein)" + }, + { + "input": "Definition: something described as an extract prepared from the fruit of Morinda citrifolia, a plant that yields various herbal preparations. Morinda citrifolia fruit juice has antioxidant properties and may prevent tumorigenesis via inhibition of DNA-carcinogen adduct formation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C26662\" active clinical trials using this agent.\nConcepts: NONI FRUIT (Plant or Plant Part Extract)\tPREVOTELLA INTERMEDIA/NIGRESCENS GROUP (Bacterium)\tFPR - facilitated positional release (Osteopathic manipulation)\tNPI1-Stubborn (NPI Questionnaire Question)\tcoll-2 (Gene or Genome)", + "output": "NONI FRUIT (Plant or Plant Part Extract)" + }, + { + "input": "Definition: Organic Chemical described as any agent that targets the human vascular endothelial growth factor receptor (VEGFR).\nConcepts: professional practice (Health Occupations)\tRespiratory Tract Absorption (Organ or Tissue Function)\tProtein Jagged-1 (Biologically Active Substance)\tVEGFR-targeting Agent (Pharmacologic Substance)\tAnimal migration (Behavior, Animal)", + "output": "VEGFR-targeting Agent (Pharmacologic Substance)" + }, + { + "input": "Definition: Structure of adductor muscle of thigh described as a muscle located in the medial compartment of the thigh that adducts, flexes, extends, and medially rotates the thigh at the hip joint. It originates on the ischiopubic ramus and ischial tuberosity, and inserts into the gluteal tuberosity of the femur, medial lip of the linea aspera, medial supracondylar ridge, and adductor tubercle. It is innervated by the obturator and tibial nerves and supplied by branches of the deep femoral and popliteal arteries, and the inferior gluteal and obturator arteries.\nConcepts: Adductor magnus (Adductor of hip joint)\tTamil Language (Language)\tSerenoa (Organic Chemical)\tcell communication (Cell Function)\tSpiritual support (rnox behavior)", + "output": "Adductor magnus (Adductor of hip joint)" + }, + { + "input": "Definition: Signaling Protein described as cellular retinoic acid-binding protein 2 (138 aa, ~16 kDa) is encoded by the human CRABP2 gene. This protein plays a role in retinoic acid signaling.\nConcepts: Cellular Retinoic Acid-Binding Protein 2 (Signaling Protein)\tradioactive isotopes (GENERAL CHEMICAL TERMS)\t3-dehydroquinate synthase activity (carbon-oxygen lyase activity, acting on phosphates)\tEpimembranous nephritis (Disease or Syndrome)\tmammary gland bud formation (morphogenesis of embryonic epithelium)", + "output": "Cellular Retinoic Acid-Binding Protein 2 (Signaling Protein)" + }, + { + "input": "Definition: Gene or Genome described as human NONO wild-type allele is located in the vicinity of Xq13.1 and is approximately 18 kb in length. This allele, which encodes non-POU domain containing, octamer-binding protein, may play a role in the mediation of transcription, RNA splicing and DNA secondary structure. The gene can be involved in an inversion inv(X)(p11.2;q12) with the TFE3 gene in some papillary renal cell carcinomas.\nConcepts: Combination Anti-Infective Agent (Anti-Infective Agents)\tStrip Dose Form (Biomedical or Dental Material)\tVz Obs by F Norm by BMI (Quantitative Concept)\t3,4-dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-\u03b2-phenylethylamine (Catecholamines)\tP54 (NONO gene)", + "output": "P54 (NONO gene)" + }, + { + "input": "Definition: Neoplastic Process described as a neoplastic condition that is relevant to either disease states or models of disease in experimental organisms.\nConcepts: Sine Oculis Homeobox (Drosophila) Homolog 4 (Amino Acid, Peptide, or Protein)\tEGFR Mutation Analysis Was Performed (Finding)\tAlcoholic liver disease, unspecified (Korean Standard Classification of Disease Version 5)\tExperimental Organism Neoplasm (Neoplastic Process)\tSinu-atrial node (Right ventricular structure)", + "output": "Experimental Organism Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.\nConcepts: Global Alignment of Immunization safety Assessment in pregnancy Insufficient Evidence for Diagnosis of Gestational Diabetes Mellitus (Intellectual Product)\tfetoprotein (Proteins)\tendoplasmic reticulum signal peptide binding (Molecular Function)\tSomatic dysfunction of sphenobasilar synchondrosis (Finding)\tSIALOGR (Radiography of head or neck)", + "output": "endoplasmic reticulum signal peptide binding (Molecular Function)" + }, + { + "input": "Definition: something described as an indication that human herpesvirus 8 has been detected in a sample.\nConcepts: Chromosome X Open Reading Frame 53 Gene (BRCC3 gene)\tDental surface disorders (Dental and gingival conditions)\tMLL/ARHGEF12 Fusion Gene (Gene or Genome)\tcerebral projection fibers (Cell Component)\tHuman Herpesvirus-8 Positive (Laboratory or Test Result)", + "output": "Human Herpesvirus-8 Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: Psychologist described as a psychologist with a proficiency that involves the application of psychological treatment of addiction stemming from the use of alcohol and other psychoactive substances (e.g., nicotine, marijuana, cocaine, heroin) or behavioral addictions (e.g., gambling) with the aim of cessation or reduction of use and/or the amelioration of emotional, behavioral, interpersonal and other problems arising from the addictive behavior.\nConcepts: MRt (Body Part, Organ, or Organ Component)\tSphincter, Velopharyngeal (Anatomical line)\tPsychologist - Addiction (Professional or Occupational Group)\tAEO (Fatty Acids)\tHSCR1 protein, human (RET Gene Product)", + "output": "Psychologist - Addiction (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as a functional anomaly of that portion of the cardiosvascular system that carries deoxygenated blood from the heart to the lungs and returns oxygenated blood back to the heart.\nConcepts: Kerstersia gyiorum Coenye et al. 2003 (Kerstersia)\tPlanned Activity Blinded Description (Intellectual Product)\tcytoskeletal protein (Scleroproteins)\tRECEPTOR MELANOCORTIN TYPE 03 (melanocortin receptor)\tAbnormality of pulmonary circulation (Abnormal breathing)", + "output": "Abnormality of pulmonary circulation (Abnormal breathing)" + }, + { + "input": "Definition: Tumor Necrosis Factor Receptor-Associated Peptides and Proteins described as a 34 kDa signal transducing adaptor protein that associates with TUMOR NECROSIS FACTOR RECEPTOR TYPE 1. It facilitates the recruitment of signaling proteins such as TNF RECEPTOR-ASSOCIATED FACTOR 2 and FAS ASSOCIATED DEATH DOMAIN PROTEIN to the receptor complex.\nConcepts: acetylcholine receptor activity (transmembrane signaling receptor activity)\tIron-Molybdenum Cofactor (Nitrogenase)\tAbnormal TLCO (Lung function testing abnormal)\tTNFR1-Associated DEATH Domain Protein (Amino Acid, Peptide, or Protein)\tShoe Covers, Surgical (Manufactured Object)", + "output": "TNFR1-Associated DEATH Domain Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.\nConcepts: Low-Grade Astrocytic Neoplasm (Astrocytoma)\tIrrigation (Therapeutic or Preventive Procedure)\tBreast Cancer Clinical Regional Lymph Nodes TNM Finding v7 (Finding)\tPseudolymphoma of Spiegler (Lymphoproliferative Disorder of the Skin)\tL-arginine import across plasma membrane (Cell Function)", + "output": "L-arginine import across plasma membrane (Cell Function)" + }, + { + "input": "Definition: something described as this gene is involved in cell communication and signal transduction.\nConcepts: phosphoenolpyruvate carboxylase (Molecular Function)\tintegrin subunit beta 5 (Gene or Genome)\tCDISC SEND Severity Terminology (Intellectual Product)\tPleural Fluid Supernatant (Supernatant)\tHomeobox Protein en-2 (Amino Acid, Peptide, or Protein)", + "output": "integrin subunit beta 5 (Gene or Genome)" + }, + { + "input": "Definition: Molality Unit described as a rate unit expressed in nanomole(s) per liter of solution per period of time equal to sixty minutes.\nConcepts: pmol/mL/h (Quantitative Concept)\tGrade 1 Thyroid Stimulating Hormone Increased, CTCAE (Finding)\tVenous System Endothelium (Tissue)\tUnknown History of Kawasaki Disease (Medical History)\tCTCAE Grade 1 Myositis (Myositis, CTCAE 3.0)", + "output": "pmol/mL/h (Quantitative Concept)" + }, + { + "input": "Definition: Plant Part described as the outermost layer of the mature ovary wall.\nConcepts: Pancreatic Insulin Producing NET (Neoplastic Process)\tregulation of natural killer cell granule exocytosis (regulation of natural killer cell mediated cytotoxicity)\thelper T cell chemotaxis (Cell Function)\tInto (Unapproved attribute)\tExocarpium (Plant Part)", + "output": "Exocarpium (Plant Part)" + }, + { + "input": "Definition: Abnormality of the immune system described as a functional abnormality of the immune system.\nConcepts: OMOD1 (Omodysplasia)\tAnal Buschke-Lowenstein Tumor (Verrucous carcinoma)\tAbnormality of immune system physiology (Pathologic Function)\tTissue Culture Shared Resource (Health Care Related Organization)\tANTIMICROBIALS (Pesticides)", + "output": "Abnormality of immune system physiology (Pathologic Function)" + }, + { + "input": "Definition: Numbers described as does Not Interfere\nConcepts: Progressive Neoplastic Disease (Neoplastic Process)\tArabic numeral 0 (Arabic numeral)\tmaltose transport complex location, core subunit (Cell Component)\tMagnetic Resonance Safe (Functional Concept)\tEra (Gene or Genome)", + "output": "Arabic numeral 0 (Arabic numeral)" + }, + { + "input": "Definition: Social group described as social groups used as sources for personal and behavioral identification, motivation, and evaluation of one's own status.\nConcepts: DINACICLIB (Pharmacologic Substance)\tPREVOTELLA HISTICOLA (Prevotella)\tReference Group (Social group)\tautologous NY-ESO-1-melanoma-specific CD8+ T cells (Cell)\tcolitis eosinophilic (Colitis)", + "output": "Reference Group (Social group)" + }, + { + "input": "Definition: regulation of antimicrobial peptide production described as any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis.\nConcepts: Estrogen Receptor 1 Gene Mutation (Cell or Molecular Dysfunction)\tPODCI - ADOLESCENT PARENT REPORTED (Clinical or Research Assessment Questionnaire)\tgastroenterostomy (Bypass of esophagus)\ttrophectoderm cell proliferation (Cell Function)\tregulation of antimicrobial peptide biosynthetic process (regulation of cellular biosynthetic process)", + "output": "regulation of antimicrobial peptide biosynthetic process (regulation of cellular biosynthetic process)" + }, + { + "input": "Definition: Physiologic Function described as enzyme Reactivation involves initiation of function, following prior inhibition, of a biological molecule that possesses catalytic activity.\nConcepts: Pilocarpus (Amyridoideae)\tpoly-gamma-glutamate metabolic process (cellular macromolecule metabolic process)\tDeploy, Difficult To (Finding)\tEnzyme Reactivation (Physiologic Function)\tAcquired monoclonal immunoglobulin light chain-associated Fanconi syndrome (Renal Tubular Acidosis, Type II)", + "output": "Enzyme Reactivation (Physiologic Function)" + }, + { + "input": "Definition: Organic Chemical described as a substance that is being studied as a treatment for advanced prostate cancer and for pain caused by prostate cancer that has spread to the bone. It belongs to the family of drugs called endothelin ETA receptor antagonists.\nConcepts: Piezoelectric Orthopedic External Shock Wave Therapy Systems (Medical Device)\tglomus development (Organ or Tissue Function)\tAdult Botryoid Sarcoma (Botryoid-Type Embryonal Rhabdomyosarcoma)\tYM598 (Organic Chemical)\tendoplasmic reticulum tubular network membrane organization (endoplasmic reticulum tubular network organization)", + "output": "YM598 (Organic Chemical)" + }, + { + "input": "Definition: Regulators described as power supplies designed to deliver an almost steady, predetermined value of AC voltage (e.g., 120 V) for a limited range of input line voltage variations (e.g., plus or minus 10%). These devices typically include an electronic line voltage monitor to detect line voltage fluctuations and some electric or electronic stabilization circuit or device to compensate for these variations. Line voltage stabilizing power supplies are mostly used to maintain normal operation of electrical equipment (e.g., motors, pumps, lights, refrigerators) under reduced-voltage conditions (brownouts).\nConcepts: Performance fear (Fear symptoms and phobic disorders)\tethanolamine kinase (kinase activity)\tActinomyces radingae Wust et al. 1995 emend Vandamme et al. 1998 (Actinomyces)\tDiagnostic arthroscopy of hip joint (Other incision of hip)\tPower Supplies, Line-Voltage Stabilization (Regulators)", + "output": "Power Supplies, Line-Voltage Stabilization (Regulators)" + }, + { + "input": "Definition: Poaceae described as prolamins in the endosperm of SEEDS from the Triticeae tribe which includes species of WHEAT; BARLEY; and RYE.\nConcepts: Gluten Proteins (Amino Acid, Peptide, or Protein)\tTendon approximator (Approximator)\tCDK2-associated protein 2 (Genes, cdc)\tacyl coa dehydrogenase (Oxidoreductase)\t2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (Molecular Function)", + "output": "Gluten Proteins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Disorder of keratinization described as hyperkeratosis is thickening of the outer layer of the skin, the stratum corneum, which is composed of large, polyhedral, plate-like envelopes filled with keratin which are the dead cells that have migrated up from the stratum granulosum.\nConcepts: Breast Cancer by AJCC v8 Prognostic Stage (Breast Cancer by AJCC v8 Stage)\tInterleukin (Amino Acid, Peptide, or Protein)\tCA 125 (Immunologic Factor)\tskin hyperkeratosis (Hyperkeratosis)\tLimb Salvage (Therapeutic or Preventive Procedure)", + "output": "skin hyperkeratosis (Hyperkeratosis)" + }, + { + "input": "Definition: pantothenic acid described as an alcoholic analogue of D-pantothenic acid and cholinergic agent. Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine. Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.\nConcepts: farnesylated protein binding (Protein Binding)\t2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide (OTHER OPHTHALMOLOGICALS IN ATC)\tcrossbridge (Cell Component)\tMercury compounds (Inorganic Chemical)\tDeleted in Liver Cancer 1 wt Allele (DLC1 gene)", + "output": "2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide (OTHER OPHTHALMOLOGICALS IN ATC)" + }, + { + "input": "Definition: Oxidoreductase Gene described as this gene plays a role in fatty acid metabolism.\nConcepts: Lamellated Corpuscle (Contact receptor)\tGallbladder Cancer pTX TNM Finding v7 (Finding)\tdelta-9-desaturase (Oxidoreductase Gene)\tfolic acid binding (amide binding)\tsurvivin Sur1M2 peptide vaccine (Immunologic Factor)", + "output": "delta-9-desaturase (Oxidoreductase Gene)" + }, + { + "input": "Definition: Dermatitis and eczema described as an X-linked recessive autoimmune condition caused by mutation(s) in the FOXP3 gene, encoding the forkhead box P3 transcription factor. The condition is characterized by infantile onset of severe diarrhea due to enteropathy, type 1 diabetes mellitus, and dermatitis. Associated features may include hypothyroidism, autoimmune hemolytic anemia, thrombocytopenia, lymphadenopathy, hepatitis, and nephritis. The condition is usually fatal before age 2 years if not treated with bone marrow transplantation.\nConcepts: DD-mediated complex assembly (protein-containing complex assembly)\tExclude Body Weight Gain Data From Statistics Indicator (Finding)\tupregulation of interleukin-5 production (positive regulation of cytokine production)\tPancreatic hyperplasia (Finding)\tCongen diab mell secret diarrh (Polyglandular endocrine disorders)", + "output": "Congen diab mell secret diarrh (Polyglandular endocrine disorders)" + }, + { + "input": "Definition: something described as initiating, maintaining, shaping and terminating a dialogue or interchange with more than one individual, such as in starting and participating in a group interchange.\nConcepts: Conversing with many people (Social Behavior)\tglycerides (Lipids)\tVasoproliferative tumour of retina (Benign neoplasm of retina)\tOther (Other Finding)\tPubic Hair (Entire hair of trunk)", + "output": "Conversing with many people (Social Behavior)" + }, + { + "input": "Definition: CRQ-SAS First Administration Version Questionnaire Question described as chronic Respiratory Questionnaire Self-Administered Standardized Format First Administration Version Questionnaire (CRQ-SAS First Administration Version) How often during the last 2 weeks have you felt low in energy?\nConcepts: Elastolysis (Congenital anomaly of integument)\tnecroptotic execution phase (cellular process)\tSite Representative Investigator (Professional or Occupational Group)\tregulation of semaphorin-plexin signalling pathway (regulation of signal transduction)\tCRQ01-Felt Low in Energy (Intellectual Product)", + "output": "CRQ01-Felt Low in Energy (Intellectual Product)" + }, + { + "input": "Definition: Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8 described as lip and oral cavity cancer with tumor size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than 10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm or less DOI.\nConcepts: S152 (Cell Count)\tLip and Oral Cavity Cancer pT2 TNM Finding v8 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8)\tGDS - Geriat depression scale (depression scale)\tPheochromocytoma (Sympathetic paraganglioma)\tadenose (Dysplasia)", + "output": "Lip and Oral Cavity Cancer pT2 TNM Finding v8 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: sulfhydryl oxidase activity described as catalysis of the formation of disulfide bridges.\nConcepts: Random Access Memory Device (Memory Device)\tTumor Antigen-specific Antibody (Amino Acid, Peptide, or Protein)\tUrethral Cancer Clinical TNM Finding v7 (Finding)\tMYCOL (Occupation or Discipline)\tflavin-linked sulfhydryl oxidase activity (Molecular Function)", + "output": "flavin-linked sulfhydryl oxidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the ground tissue occupying the center of the root within the vascular cylinder; usually consists of parenchyma.\nConcepts: positive regulation of CTLA-8 secretion (positive regulation of interleukin-17 production)\tPith, Root (Plant Part)\tDevice system (Device Component or Accessory)\tWAVE regulatory complex (protein-containing complex)\tspermine biosynthetic process (Molecular Function)", + "output": "Pith, Root (Plant Part)" + }, + { + "input": "Definition: structural molecule activity described as the action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve.\nConcepts: structural constituent of myelin sheath (structural molecule activity)\tCase Managers (Health Personnel)\tSingle fiber EMG abnormality (Anatomical Abnormality)\tCTX (Peptides)\tAssisted Ventilation, Liquid (Therapeutic or Preventive Procedure)", + "output": "structural constituent of myelin sheath (structural molecule activity)" + }, + { + "input": "Definition: Hyperopia, High described as a term to describe when farsightedness is masked when the accommodative muscles are used to increase the focusing power of the eye. []\nConcepts: Latent hypermetropia (Hyperopia, High)\tcollagen type VI location (collagen location)\tHER2 Bispecific Antibody KN026 (Anti-HER2 Monoclonal Antibody)\tSupraglottic Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Finding)\tCharacteristic Modified Indicator (Indicator)", + "output": "Latent hypermetropia (Hyperopia, High)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.\nConcepts: finasteride (Synthetic antiestrogen, NOS)\tMetastases to pituitary gland (Metastatic Malignant Neoplasm in the Sellar Region)\tNeurocognitive disorder (Cognition Disorders)\tferrichrome synthesis (ferrichrome metabolic process)\t15: 78483887-78677329 (Chromosome 15 Physical Location)", + "output": "ferrichrome synthesis (ferrichrome metabolic process)" + }, + { + "input": "Definition: Croatian translation of the Medical Subject Headings described as infections or infestations with parasitic organisms; they are often contracted through contact with an intermediate vector, but may occur as the result of direct exposure.\nConcepts: ZEN4, C. ELEGANS, HOMOLOG OF (Gene or Genome)\tRefractory Malignant Thyroid Gland Neoplasm (Refractory Malignant Head and Neck Neoplasm)\tclathrin-sculpted gamma-aminobutyric acid transport vesicle (Cell Component)\tReceptors, P2Y2 (Receptors, Purinergic P2Y)\tdisease caused by a parasite (Physical & Psychosomatic Disorders)", + "output": "disease caused by a parasite (Physical & Psychosomatic Disorders)" + }, + { + "input": "Definition: Neoplastic Process described as a serous adenocarcinoma that arises from the lining of the peritoneum. It is characterized by high grade histopathologic features.\nConcepts: positive regulation of cell migration (positive regulation of cell motility)\t13q12 (Chromosome band)\tSURG SCISSORS (Scissors)\tAutobiographies as Topic (Biography as Topic)\tPrimary Peritoneal High-Grade Serous Adenocarcinoma (Primary Peritoneal Serous Adenocarcinoma)", + "output": "Primary Peritoneal High-Grade Serous Adenocarcinoma (Primary Peritoneal Serous Adenocarcinoma)" + }, + { + "input": "Definition: Idea or Concept described as influenced to undertake a course of action or embrace a point of view by means of argument, reasoning, or entreaty.\nConcepts: positive regulation of ethanol catabolic process by positive regulation of transcription from RNA polymerase II promoter (Genetic Function)\tpersuasive communication (Idea or Concept)\tAlbania (Geographic Area)\tB-cell homeostatic proliferation (B Cell Proliferation)\tIVD Test Reagent/Kits, Serology, Virus, Arenavirus (IVD Test Reagent/Kits, Serology, Virus)", + "output": "persuasive communication (Idea or Concept)" + }, + { + "input": "Definition: Acids, Acyclic described as derivatives of caproic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated six carbon aliphatic structure.\nConcepts: Caproates (Acids, Acyclic)\tNYN domain and retroviral integrase containing (Ligand Binding Protein Gene)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Yersinia pestis (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Yersinia Species)\tElectrical alternation of heart (Electrocardiogram abnormal)\tMedication Administration: Subcutaneous (Introduction of therapeutic substance into soft tissue)", + "output": "Caproates (Acids, Acyclic)" + }, + { + "input": "Definition: Hereditary disorder of cellular element of blood described as an autosomal dominant disorder characterized by thrombocytopenia, giant platelets, nephritis, and deafness; it is associated with mutation of the MYH9 gene.\nConcepts: Condensed Activity (Molecular Biology Research Technique)\tScheduled Substance Administration Product Dose Description (Product Dose Description)\tVelcade/adriamycin/dexamethasone regimen (Therapeutic or Preventive Procedure)\tHave Weakness on One Side of Body (Clinical or Research Assessment Question)\tepstein's syndrome (Chronic disease of hematopoietic system)", + "output": "epstein's syndrome (Chronic disease of hematopoietic system)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic organic thiophosphate compound and organophosphate acetylcholinesterase inhibitor that is the methyl homolog of parathion and is used as a pesticide. It is characterized as a colorless to white or tan crystalline solid that is odorless or has a pungent garlic-like odor, and exposure occurs by inhalation, ingestion, or contact.\nConcepts: Methyl parathion -RETIRED- (Hazardous or Poisonous Substance)\tScience of Virology (Biomedical Occupation or Discipline)\tModifier (Property or Attribute)\tThe Breast-Impact of Treatment Scale (Research or Clinical Assessment Tool)\tGenus Amazona (Bird)", + "output": "Methyl parathion -RETIRED- (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 19q\nConcepts: Gram Negative Bacteria Measurement (Microbiology procedure)\t19q13.3-q13.4 (Chromosome band)\tAbnormal autonomic nervous system morphology (Abnormality of the autonomic nervous system)\tSpiradenoma eccrine (Benign Neoplasm)\tExercise Therapy: Muscle Control (Therapeutic or Preventive Procedure)", + "output": "19q13.3-q13.4 (Chromosome band)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as an anticancer drug that belongs to the family of drugs called antimetabolites.\nConcepts: 4-Amino-PGA (Rodenticides)\tTigecycline-containing product (Anti-Bacterial Agents)\tTelomere (Cell Component)\tVaginal cyst (Abdominal mass)\tPEGDMA Hydrogels (Pharmacologic Substance)", + "output": "4-Amino-PGA (Rodenticides)" + }, + { + "input": "Definition: Hepatobiliary Disorder described as a carcinoma arising from the intrahepatic or extrahepatic bile ducts.\nConcepts: Increased blood lactate (Acidosis)\tStudyInvestigator (Research Personnel)\tBile duct carcinoma (Biliary Tract Cancer)\tprerubral tract (Body Part, Organ, or Organ Component)\tKnown History of Allergy to Medication (Finding)", + "output": "Bile duct carcinoma (Biliary Tract Cancer)" + }, + { + "input": "Definition: something described as human FOXP1 wild-type allele is located in the vicinity of 3p14.1 and is approximately 629 kb in length. This allele, which encodes forkhead box protein P1, plays a role in the negative regulation of transcription. Mutation of the gene is associated with mental retardation with language impairment and autistic features. A translocation t(9;3)(p13;p14.1) of this gene with the PAX5 gene is associated with acute lymphoblastic leukemia.\nConcepts: Synechocystis (Cyanobacteria)\tHave Tingling Fingers or Hands (Clinical or Research Assessment Question)\tMedical Device Mechanical Issue (Device physical property issue)\tHave you felt embarrassed because of your urostomy (Intellectual Product)\tMGC99551 (FOXP1 gene)", + "output": "MGC99551 (FOXP1 gene)" + }, + { + "input": "Definition: Health Care Related Organization described as the section of a hospital or clinic staffed and equipped to provide immediate medical treatment.\nConcepts: L-serine catabolic process (L-serine metabolic process)\tset of teeth (Body part)\tcontralateral (Spatial Concept)\tFistula, Stomach (Digestive System Fistula)\tEmergency Service, Hospital (Health Care Related Organization)", + "output": "Emergency Service, Hospital (Health Care Related Organization)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue.\nConcepts: prenylcysteine metabolism (sulfur amino acid metabolic process)\tGrade 1 Thrush, CTCAE (Finding)\tLOCATOR, INTRACORPOREAL DEVICE, ULTRASONIC (Medical Device)\tGarcinia morella / gambogia (Organic Chemical)\tent-kaur-16-en-19-al oxidase activity (Molecular Function)", + "output": "prenylcysteine metabolism (sulfur amino acid metabolic process)" + }, + { + "input": "Definition: something described as charcot-Marie-Tooth disease, type 4G (CMT4G) is a demyelinating CMT peripheral sensorimotor polyneuropathy. Onset occurs between 8 and 16 years of age with distal lower limb weakness, followed by distal upper limb involvement with a more variable age of onset of between 10 and 43 years. Sensory loss is also a prominent feature. The disease-causing gene has not yet been identified but linkage analysis and recombination mapping have led to identification of a small interval on 10q23.2. Transmitted in an autosomal recessive manner.\nConcepts: Mexiletine (Antiarrythmic drugs)\tVision check NOS (Vision Tests)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, DHCR7 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tglanders due to Malleomyces mallei (Bacterial Zoonoses)\tCmt4g (Disease or Syndrome)", + "output": "Cmt4g (Disease or Syndrome)" + }, + { + "input": "Definition: tyrothricin described as a group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.\nConcepts: Extracardiac Examination (Diagnostic Procedure)\tMassage therapy referral no charge (Health Care Activity)\tGramicidin product (Topical anti-infective)\tPosterior crocodile shagreen of the cornea (Central corneal dystrophy)\tmethyl coenzyme M reductase complex location (Cell Component)", + "output": "Gramicidin product (Topical anti-infective)" + }, + { + "input": "Definition: something described as complete loss of ability to move facial muscles innervated by the facial nerve (i.e., the seventh cranial nerve).\nConcepts: Cytomegalovirus, guinea pig (Virus)\tpalsy facial (Facial Nerve Diseases)\tCardiopulmonary (Anatomy Qualifier)\tUPD2-Pain and other Sensations (Intellectual Product)\tMethadone product (Narcotics)", + "output": "palsy facial (Facial Nerve Diseases)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination.\nConcepts: LET7A1, stRNA (Gene or Genome)\tBOCA (Gene or Genome)\tPhenylalanine Ammonia-Lyase (Ammonia-Lyases)\tSperm Motility (Motility)\tdown-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (Cell Function)", + "output": "down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (Cell Function)" + }, + { + "input": "Definition: Hereditary Connective Tissue Disorder described as this syndrome has characteristics of craniofacial dysplasia, cone-shaped physes of the hands and feet and neurological manifestations resembling cerebral palsy. It has been described in one family. The syndrome appeared to be transmitted as a dominant trait.\nConcepts: Craniofacial conodysplasia syndrome (Congenital anomaly of face bones)\tMonosporium apiospermum (Pseudallescheria boydii and/or Scedosporium boydii complex)\tCDRS-R - Social Withdrawal (CDRS-R Clinical Classification Question)\tCases (Potency Unit)\tsemaphorin-plexin signalling pathway involved in outflow tract morphogenesis (Molecular Function)", + "output": "Craniofacial conodysplasia syndrome (Congenital anomaly of face bones)" + }, + { + "input": "Definition: small cell carcinoma of salivary gland described as an infrequent small cell carcinoma that arises from a minor salivary gland and is characterized by the presence of a high number of mitotic figures.\nConcepts: emulsion (Chemical Viewed Structurally)\tMinor Salivary Gland Small Cell Carcinoma (Neoplastic Process)\tmesonephric glomerular parietal epithelial cell differentiation (Cell Function)\tRETROCRURAL LYMPH NODE (Lymph Node by Anatomic Site)\tDevice.reprocessedDeviceCode (Intellectual Product)", + "output": "Minor Salivary Gland Small Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Syndrome described as an autosomal recessive condition caused by mutation(s) in the TBCE gene, encoding tubulin-specific chaperone E. It is characterized by congenital hypoparathyroidism, mental retardation, seizures and developmental delay.\nConcepts: Filters, Air, Gas/Vapor, Toxic Industrial Contaminant (Filters, Air, Gas/Vapor)\tLegislative Liaison (Miscellaneous Occupation)\t20: 48844975-49827121 (Spatial Concept)\tDegranulation Tests, Basophil (LABORATORY IMMUNOLOGIC PROCEDURES)\tHYPOPARATHYROIDISM WITH SHORT STATURE, MENTAL RETARDATION, AND SEIZURES (Rare Non-Neoplastic Disorder)", + "output": "HYPOPARATHYROIDISM WITH SHORT STATURE, MENTAL RETARDATION, AND SEIZURES (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Cardiovascular finding described as the quantitative measurement of the effective regurgitant orifice area of a cardiac valve.\nConcepts: ECROMEXIMAB (Amino Acid, Peptide, or Protein)\tEFFRGOA (Cardiovascular finding)\tHeart-Lung Bypass Unit Air Detectors (Detectors, Air Bubble/Foam)\tr(18) syndrome (Disease or Syndrome)\tNational Library of Medicine, RxNorm Project (Intellectual Product)", + "output": "EFFRGOA (Cardiovascular finding)" + }, + { + "input": "Definition: Organism Function described as the process in which the anatomical structures of the hindlimb are generated and organized.\nConcepts: Toxicokinetic Description (Description)\tulna; hypoplasia (Congenital Abnormality)\tLeukoencephalopathy, ataxia, hypodontia, hypomyelination syndrome (Disease or Syndrome)\tBlood Product Collection (Biospecimen Collection Method)\thindlimb morphogenesis (Organism Function)", + "output": "hindlimb morphogenesis (Organism Function)" + }, + { + "input": "Definition: something described as long dan\nConcepts: Vestibular nerve (Vestibulocochlear nerve and its branches)\tFIBRILLATION ATRIAL (Fibrillation)\tAnaerococcus (Bacterium)\tGentiana scabra / long dan (Oriental herbs and natural substances letter G)\tService and Testing Personnel (Personnel)", + "output": "Gentiana scabra / long dan (Oriental herbs and natural substances letter G)" + }, + { + "input": "Definition: Mammal described as a medium-sized squarely proportioned dog that looks more like a sheepdog than a terrier. It has a fine outer coat that is straight or wavy, and a soft, wooly undercoat. The coat is long, but should not touch the ground. The feathered tail is heavily furnished and carried over the back. This breed's unique, large, flat feet are well furnished with hair and produce a snowshoe effect that provides traction and flotation in snow. The average height range is 14-17 inches and the average weight range is 18-30 pounds.\nConcepts: Hypophoria (Hypodeviation)\tPsychomotor skills group each 15 minutes (Therapeutic or Preventive Procedure)\tpurpura was seen (Dermatologic disorders)\tTibetan terrier (Dog family)\tCRSR0103 (CRS-R Clinical Classification Question)", + "output": "Tibetan terrier (Dog family)" + }, + { + "input": "Definition: Radiologic Health described as the effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.\nConcepts: Enhancer Factor, Lymphoid (TRANSCRIPTION FACTOR)\tEffects, Radiation (Radiologic Health)\tFilgrastim Regimen (Regimen Used to Treat Non-neoplastic Hematologic Disorders)\tIL-1 receptor complex (plasma membrane signaling receptor complex)\tOrphan Nuclear Receptor PXR (Receptors, Nuclear)", + "output": "Effects, Radiation (Radiologic Health)" + }, + { + "input": "Definition: something described as abnormally large size of the metaphyseal epiphyses.\nConcepts: DAS181-F02 (Pharmacologic Substance)\tAmbiguous genitalia, female (Ambiguous Genitalia)\tEnlarged end part of long bone of hand (Enlarged epiphyses)\tNeuroepithelial Cells (Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System)\tRefractory Childhood Hodgkin Lymphoma (Refractory Hodgkin Lymphoma)", + "output": "Enlarged end part of long bone of hand (Enlarged epiphyses)" + }, + { + "input": "Definition: Intellectual Product described as records pertaining to the completion of a data validation test.\nConcepts: Edit Check Validation (Document type)\tcancer of the salivary gland, poorly differentiated (Neoplastic Process)\tDialyzer Reaction (Anaphylactic and anaphylactoid responses)\tM0 leukemia, childhood acute (Childhood Acute Myeloid Leukemia Not Otherwise Specified)\tregulation of multivesicular body size (Cell Function)", + "output": "Edit Check Validation (Document type)" + }, + { + "input": "Definition: Body part described as distal part of the small intestine, extending from the jejunum to the cecum.\nConcepts: ileos (Region of small intestine)\tNeoplastic (Qualitative Concept)\tSurgical Aspirator/Irrigators (Aspirator/Irrigators)\tINO80-type complex (Cell Component)\tMethyltransferase II (Transferase)", + "output": "ileos (Region of small intestine)" + }, + { + "input": "Definition: something described as a finding that the tail has a localized undulation.\nConcepts: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor (Molecular Function)\tKINKED TAIL (Experimental Organism Finding)\tZiv-aflibercept (Angiogenesis Activator Inhibitor)\tMN1 (Transcription Coactivator Gene)\tSpinal stenoses (Spinal stenosis other than cervical)", + "output": "KINKED TAIL (Experimental Organism Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a type of radiation procedure in which radiation is applied first in an anteroposterior anatomical plane and then in a posteroanterior anatomical plane.\nConcepts: AP/PA SEQUENTIAL (Therapeutic radiology procedure)\tStage III Carcinoma of Colon AJCC v6 (Mass of digestive structure)\tParathyroid Hormone, N-Terminal (Hormone measurement)\tMedial Rectus Muscle (Body Part, Organ, or Organ Component)\tHooks, Rhinoplastic (Surgical Hooks)", + "output": "AP/PA SEQUENTIAL (Therapeutic radiology procedure)" + }, + { + "input": "Definition: Hospital Departments described as organized services in a hospital which provide medical care on an outpatient basis.\nConcepts: Hospital Outpatient Clinic (Ambulatory Care Facilities)\tGrade 4 Pharyngitis (Pharyngitis, CTCAE)\tAbdominal Ureter (Body Part, Organ, or Organ Component)\tFold in descemet membran (Anatomical Abnormality)\t3-oxalomalate glyoxylate-lyase activity (Molecular Function)", + "output": "Hospital Outpatient Clinic (Ambulatory Care Facilities)" + }, + { + "input": "Definition: Neoplastic Process described as a red-pigmented tumor that occurs in a goldfish.\nConcepts: Goldfish Erythrophoroma (Fish Experimental Organism Diagnosis)\tPORTER SILBER HYDRAZONE, 17-HYDROXYCORTICOSTEROIDS (Indicator, Reagent, or Diagnostic Aid)\tFAC061-I Have a Lack of Energy (Intellectual Product)\tPrimary Goal to Keep Hoping (Clinical or Research Assessment Question)\tLocally Extensive (Qualitative Concept)", + "output": "Goldfish Erythrophoroma (Fish Experimental Organism Diagnosis)" + }, + { + "input": "Definition: treatment - ActInformationManagementReason described as the health outcomes of a group of individuals, including the distribution of such outcomes within the group. These populations are often geographic regions, such as nations or communities, but they can also be other groups. (From Am J Public Health. 2003 March; 93(3): 380-383)\nConcepts: protein secretion by the T2SS (protein transport across the cell outer membrane)\tpartial trisomy 9q non-distal (9q partial trisomy syndrome)\t19: 778831-783017 (Spatial Concept)\tDRRI1-E: Sight/Sound/Smell Dead Animals (DRRI-2 Questionnaire Question)\tPopulation Health (treatment - ActInformationManagementReason)", + "output": "Population Health (treatment - ActInformationManagementReason)" + }, + { + "input": "Definition: something described as a triangular muscle within the iliac fossa that flexes the thigh and rotates the leg medially.\nConcepts: Anomaly of the basal ganglia (Abnormality of the cerebral subcortex)\t4-(hydroxymethyl)benzenesulfonate dehydrogenase activity (Molecular Function)\tPelvimeter (Sizer)\tNOTCHED T WAVES (Finding)\tMusculus iliacus (Muscle of pelvic girdle)", + "output": "Musculus iliacus (Muscle of pelvic girdle)" + }, + { + "input": "Definition: peptide hormone binding described as interacting selectively and non-covalently with thyrotropin-releasing hormone, a tripeptide hormone that stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary and it is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system.\nConcepts: BASC-2 (Research or Clinical Assessment Tool)\tmean (Measure of Central Tendency)\tthyrotropin releasing hormone binding (peptide hormone binding)\tWide space between 4th and 5th toe (Abnormality of the 4th toe)\tSH2D1A Gene Expression Analysis (Laboratory Procedure)", + "output": "thyrotropin releasing hormone binding (peptide hormone binding)" + }, + { + "input": "Definition: Cell Function described as any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity.\nConcepts: Delirium (Finding)\tLoss of confidence in your body (Clinical or Research Assessment Question)\tAbsent aortic valve (Congenital absence of aortic valve)\tIL12RB2 Gene (Gene or Genome)\tinhibition of host RNA polymerase II by virus (suppression by virus of host molecular function)", + "output": "inhibition of host RNA polymerase II by virus (suppression by virus of host molecular function)" + }, + { + "input": "Definition: Neoplastic Process described as an adrenal gland pheochromocytoma that has spread extensively to other anatomical sites or is no longer responding to treatment.\nConcepts: mesonephric glomerular visceral epithelial cell development (glomerular visceral epithelial cell development)\tUHDR112G (UHDRS 1999 Version Clinical Classification Question)\tFinancially poor (Financial circumstances - finding)\tLung Biopsy (Biopsy of lung or pleura)\tAdvanced Adrenal Gland Pheochromocytoma (Neoplastic Process)", + "output": "Advanced Adrenal Gland Pheochromocytoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a conjugate of two agents, estradiol and an alkylating mustard (usually mechlorethamine or non-nitrogen mustard). Estramustine is one such agent (see Estramustine Phosphate Sodium).\nConcepts: DNA ligation involved in DNA replication involved in S phase (Genetic Function)\tTrace Column of Contrast or Air Between Soft Palate and Pharyngeal Wall During Swallowing (Finding)\tpositive regulation of histamine secretion by mast cell (positive regulation of ion transport)\tFDADRIND (Conceptual Entity)\tEstradiol Mustard (Nitrogen Mustard Antineoplastic Compounds)", + "output": "Estradiol Mustard (Nitrogen Mustard Antineoplastic Compounds)" + }, + { + "input": "Definition: Eukaryote described as a superfamily of parasitic nematodes consisting of several genera. ENTEROBIUS, which occurs in humans, and Oxyuris, which occurs in horses, are two of the most common. Other genera are: Skrjabinema, Passalurus, Dermatoxys, and Probstmayria.\nConcepts: Triple Phosphate Crystals (Urine Chemistry Measurement)\tOxyuroidea (Eukaryote)\t2-mercaptobenzothiazole desulfurase activity (Molecular Function)\tFat atrophy (Skin and Subcutaneous Tissue Disorders, CTCAE)\tColiforms (Microorganism)", + "output": "Oxyuroidea (Eukaryote)" + }, + { + "input": "Definition: Modifier AND/OR qualifier described as an aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent.\nConcepts: Urea Cycle Disorder Gene Mutation Panel Reagents (Medical Device)\tKiller Cell Immunoglobulin-Like Receptor 2DL5 (Killer-Cell Immunoglobulin-Like Receptor)\tAMYLOIDOSIS, SECONDARY (Connective Tissue Diseases)\tmin.ug/ml/m2 (Quantitative Concept)\trisk factors (Finding)", + "output": "risk factors (Finding)" + }, + { + "input": "Definition: Body Fluids described as material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.\nConcepts: SPUTUM (RESPIRATORY SYSTEM: GENERAL TERMS)\tresponse to glutathione (Organism Function)\tAQ01-Emotional Upset Worse Chest Trouble (Intellectual Product)\tEmpiricism (Philosophy, Medical)\tLoratadine-containing product (Pharmacologic Substance)", + "output": "SPUTUM (RESPIRATORY SYSTEM: GENERAL TERMS)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a comprehensive set of rating scales designed to facilitate the differential diagnosis and classification of a variety of emotional and behavioral disorders of children, aid in the design of treatment plans, and provide insight into an individual's thoughts and feelings. Version three incorporates additional questionnaires, scales and forms.\nConcepts: d,1-alpha- Methylphenethylamine (Types of drugs A-G)\tPrimary hyperoxaluria type III (Disease or Syndrome)\tBehavior Assessment System for Children, Third Edition (Research or Clinical Assessment Tool)\tBasic and Applied Science (Occupation or Discipline)\tRespiratory System Findings Completion Status (Completion Status)", + "output": "Behavior Assessment System for Children, Third Edition (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Labeling, Instructions for Use or Training Problem described as problem associated with inaccuracies in any written, printed, or graphic matter that is affixed to the device or its packaging with any matter that accompanies the device including verbal instructions related to identification, technical description and use of device provided by the device manufacturers that is intended for healthcare professionals.\nConcepts: Three-Dimensional Echo-Planar Spectroscopic Imaging (Diagnostic Procedure)\tMJDIAMVS (Finding)\tInadequate Instructions for Healthcare Professional (Labeling, Instructions for Use or Training Problem)\tlipoprotein transport (Cell Function)\tDecreased glucose-6-phosphate dehydrogenase level in tissue (Abnormal glucose-6-phosphate dehydrogenase level in tissue)", + "output": "Inadequate Instructions for Healthcare Professional (Labeling, Instructions for Use or Training Problem)" + }, + { + "input": "Definition: Disease or Syndrome described as disorder caused by an interruption of the mineralization of organic bone matrix leading to bone softening, bone pain, and weakness. It is the adult form of rickets resulting from disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis.\nConcepts: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen - Hands Are Weak (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)\tlymphoma liver (Neoplastic Process)\tATOMOXETINE HYDROCHLORIDE (Antidepressive Agents)\tToluidine Blue Staining Method (Special Histology Staining Method)\tOsteomalacia (Vitamin D Deficiency)", + "output": "Osteomalacia (Vitamin D Deficiency)" + }, + { + "input": "Definition: positive regulation of cellular biosynthetic process described as any process that activates or increases the frequency, rate or extent of spermidine biosynthetic process.\nConcepts: Word Recall: Word [1] (Intellectual Product)\tup-regulation of spermidine formation (positive regulation of cellular amine metabolic process)\tVFQ25-Interviewer Administered Format - Have to Rely On Other People Because of Eyesight (Intellectual Product)\tmedication course number (Quantitative Concept)\tchloromas (Neoplastic Process)", + "output": "up-regulation of spermidine formation (positive regulation of cellular amine metabolic process)" + }, + { + "input": "Definition: Cell Component described as the end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation.\nConcepts: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration (actin cytoskeleton organization)\thyphal tip (Cell Component)\tExtent of Trouble Having Physical Contact with Family or Friends (Intellectual Product)\tRight alare (Alare)\tPacked Column Gas Chromatography Systems (Chromatography Systems, Gas)", + "output": "hyphal tip (Cell Component)" + }, + { + "input": "Definition: DNA Repair Pathway described as nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.\nConcepts: Benztropine-containing product (Anticholinergic Agents)\tOromucosal Drops Dosage Form (Oromucosal AND/OR gingival dosage form)\tFAC01810 (FACT-LYM Version 4 Questionnaire Question)\tSoftware, Magnetic Resonance Imaging Scanning, Extremity (Software, Magnetic Resonance Imaging Scanning)\tNon-homologous end-joining (Functional Concept)", + "output": "Non-homologous end-joining (Functional Concept)" + }, + { + "input": "Definition: Mental Processes described as emotional sensations.\nConcepts: Nephroureterectomy (Ureterectomy)\tfeelings (Mental Processes)\tHepatocyte Growth Factor Receptor Gene Deletion (Gene Deletion Abnormality)\tTopical Betulinic Acid (Pharmacologic Substance)\tregulation of transcription from RNA polymerase II promoter by glucose (Genetic Function)", + "output": "feelings (Mental Processes)" + }, + { + "input": "Definition: Diffuse large B-cell lymphoma refractory described as mediastinal (thymic) large B-cell lymphoma that is resistant to treatment.\nConcepts: ScheduledSubstanceAdministration.activeIngredientDose (Active Ingredient Dose)\tRefractory Mediastinal (Thymic) Large B-Cell Cell Lymphoma (Neoplastic Process)\tIncreased urinary galactosylated oligosaccharide (Oligosacchariduria)\tCarcinoma, Male Breast (Primary malignant neoplasm of male breast)\tLiver Partial Response GvHD (Partial Response in GvHD)", + "output": "Refractory Mediastinal (Thymic) Large B-Cell Cell Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the microtubule-associated protein tau (MAPT) gene, located at chromosome 17q21.1, which encodes for the microtubule-associated protein tau (MAPT). The MAPT transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. Mutations at this locus have been identifed in patients with a variety of frontotemporal dementias.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MAPT (Medical Device)\tPositive Airway Pressure Units, Bi-Level (Positive Airway Pressure Units)\tearly experience (Event Experiences)\tcortisol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tC-SSRS Since Last Visit - Most Lethal Actual Attempt Potential Lethality (C-SSRS Since Last Visit Questionnaire Question)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MAPT (Medical Device)" + }, + { + "input": "Definition: something described as perque(TM) 1 Lipotropic and Amino Acid each 60 tablets. UPC Code 791760015907.\nConcepts: Webster Deming syndrome (Congenital anomaly of bone and joint)\tClinical Stage IIB Gastric Carcinoma AJCC v8 (Neoplastic Process)\tAdult-onset immunodeficiency with anti-interferon-gamma autoantibodies (Disease or Syndrome)\tperque 1lipotropic&aa ea.60 (Nutraceuticals)\tKingdom Protozoa trophozoite (Protozoa)", + "output": "perque 1lipotropic&aa ea.60 (Nutraceuticals)" + }, + { + "input": "Definition: something described as hematology reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically plasma) to determine the activated form of coagulation factor XIII (i.e., factor XIIIa) as the result of the combined action of thrombin and calcium in the final stage of the clotting cascade.\nConcepts: Pharmacokinetic Parameter Date Time (Temporal Concept)\tMOPIDAMOL (Pharmacologic Substance)\tprotein localisation to organelle (Cell Function)\tIVD Test Reagent/Kits, Hematology, Coagulation Factor XIII, Activated (Medical Device)\tregulation of activation-induced cell death of T cells (Cell Function)", + "output": "IVD Test Reagent/Kits, Hematology, Coagulation Factor XIII, Activated (Medical Device)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.\nConcepts: K48-linked polyubiquitin modification-dependent protein binding (Molecular Function)\tGrade 3 Gastric ulcer (Finding)\tAbility to administer parenteral medication (Ability to self-administer medication)\tMitochondrial encephalocardiomyopathy due to transmembrane protein 70 mutation (Hereditary disorder of musculoskeletal system)\tBIOL MARINE (biology)", + "output": "K48-linked polyubiquitin modification-dependent protein binding (Molecular Function)" + }, + { + "input": "Definition: Accessory Supraoptic Group described as a group of cells located in the central part of the anterior hypothalamic nucleus in the anterior hypothalamic region of the rat ( Swanson-2004 ) and the mouse ( Paxinos-2001 ). Functionally it belongs to the magnocellular neuroendocrine cell groups of the subcortical motor system ( Swanson-2004 ).\nConcepts: Mascot Scoring Engine (Tandem Mass Spectrometry Scoring Engine)\tnucleus circularis (Body Part, Organ, or Organ Component)\tIVD Test Reagent/Kits, Serology, Virus, Hepatitis C (Medical Device)\tCarcinoma of Choroid Plexus (Neoplastic Process)\tumbilical cord blood-derived natural killer cells (Cell)", + "output": "nucleus circularis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Neoplastic Process described as a glioblastoma that arises de novo. It is more commonly seen in older patients. Mutations in IDH1 or IDH2 genes are not present.\nConcepts: A Medium Amount of Time (Finding)\tRectal Obstruction (Gastrointestinal Obstruction, CTCAE)\tFat estimated intake from oral nutrition in 24 hours (Quantitative Concept)\tBLS-ILS-E710c (Cancer Vaccines)\tPrimary Glioblastoma (Neoplastic Process)", + "output": "Primary Glioblastoma (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of subject identifier.\nConcepts: Subject Identifier Type Code (Type Code)\tDocumentVersionWorkflowStatus.comment (Published Comment)\tCFU-E (Cell)\tglycolytic fermentation via PFL pathway (glycolytic fermentation)\tInterleukin 35, EBI3 Subunit (EBI3 gene)", + "output": "Subject Identifier Type Code (Type Code)" + }, + { + "input": "Definition: modulation by symbiont of host receptor-mediated signal transduction described as any process in which the symbiont modulates the frequency, rate or extent of transmembrane receptor-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Cytokine-containing product (Mediator of immune response)\tVascular Access Graft Failure (Finding)\tmodulation by symbiont of host transmembrane receptor-mediated signal transduction (Organism Function)\tcatalytic activity, acting on a glycoprotein (Molecular Function)\tLabor and employment services, systems and policies (CHAPTER 5 SERVICES, SYSTEMS AND POLICIES)", + "output": "modulation by symbiont of host transmembrane receptor-mediated signal transduction (Organism Function)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the basophilic normoblasts in a biological specimen taken from a non-human organism.\nConcepts: malabsorption (disorder of jejunum and ileum)\tGrade 3 Intraoperative Splenic Injury, CTCAE (Finding)\tNORMBASO (Laboratory Procedure)\tHMM Forward-only (algorithm)\tParameterizable Application (UML Entity)", + "output": "NORMBASO (Laboratory Procedure)" + }, + { + "input": "Definition: Spatial Concept described as physical location of FGF7_Gene\nConcepts: VENTRICULAR HYPERTROPHY, LEFT (Cardiovascular finding)\tmolecular probes (Indicators and Reagents)\tKNL1 (Genes, cdc)\t15: 47502751-47566815 (Spatial Concept)\tPseudoepiphyses of the middle phalanges of the hand (Abnormality of the epiphyses of the middle phalanges of the hand)", + "output": "15: 47502751-47566815 (Spatial Concept)" + }, + { + "input": "Definition: something described as reduced antithrombin antigen. A reduced level of antithrombin may lead to an increased risk of thrombus formation. []\nConcepts: Anti-CD30 Antibody-drug Conjugate (Pharmacologic Substance)\tFAC00823 (FACT-C Version 4 Questionnaire Question)\tSpecify Mutation Analysis Method (Specify Molecular Abnormality Analysis Method)\tDachshund, NOS (Canis familiaris)\tReduced antithrombin antigen (Abnormality of the common coagulation pathway)", + "output": "Reduced antithrombin antigen (Abnormality of the common coagulation pathway)" + }, + { + "input": "Definition: Abnormality of the rib cage described as malformation of the rib cage.\nConcepts: 1: 15596096-15564103 (Spatial Concept)\tprotein guanylyltransferase activity (guanylyltransferase activity)\tadrenal adenocarcinoma (Malignant neoplasm of adrenal cortex)\tSteele-Richardson-Olszewski Disease (Motor Neuron Disease)\tDeformed rib cage (Ribs, sternum, clavicles, and scapulae)", + "output": "Deformed rib cage (Ribs, sternum, clavicles, and scapulae)" + }, + { + "input": "Definition: Retriever described as a large, athletic retriever with a distinctive crisp curly coat. The thick black or liver-colored coat of tight curls protects the dog from brambles and icy water. The smallish ears are pendant. The average height range is 25-27 inches and the average weight range is 65-80 pounds.\nConcepts: Care Facilities, Intermediate (Health Care Related Organization)\tbisphenol A hydroxylase A activity (Molecular Function)\tChoroidal and Ciliary Body Melanoma pT3b TNM Finding v8 (Finding)\tCurly-coated retriever (Mammal)\tATM kinase inhibitor AZD0156 (Antineoplastic Enzyme Inhibitor)", + "output": "Curly-coated retriever (Mammal)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Dermatophagoides farinae antigen IgE antibody in a biological specimen.\nConcepts: MECONIUM (Laboratory Procedure)\tNon-Infiltrating Ductal Carcinoma and ILC (Ductal Breast Carcinoma In Situ and Invasive Lobular Carcinoma)\tD. farinae Antigen IgE Antibody (Immunoglobulin measurement)\tPolymyositis (Muscle infections and inflammations)\tsedimentation (separation method)", + "output": "D. farinae Antigen IgE Antibody (Immunoglobulin measurement)" + }, + { + "input": "Definition: Branchial arch structure described as the second of the six pharyngeal arch pairs, which are formed of mesodermal outpouchings and located on either side of the developing pharynx; structures formed from the second arch include the stapes, the temporal styloid process, the stylohyoid ligament, the lesser cornu of the hyoid bone, and multiple muscle groups, including the muscles of facial expression.\nConcepts: cysteine protease inhibitor activity (Molecular Function)\tSERPINA8 (Proteinase Inhibitor Gene)\tSecond branchial arch structure (Embryonic Structure)\tTrapezium-Trapezoid Joint (Wrist joint)\t4-hydroxybutyrate CoA-transferase activity (CoA-transferase activity)", + "output": "Second branchial arch structure (Embryonic Structure)" + }, + { + "input": "Definition: Karyotype morphology described as the chromosomal constitution of cells, in which each type of CHROMOSOME is represented once. Symbol: N.\nConcepts: Colonic Obstruction, CTCAE 5 (Gastrointestinal Disorders, CTCAE)\tCORONARY CIRC (Organ or Tissue Function)\tTaxane Analogue TPI 287 (Taxane-Pocket Binding Agent)\thaploidy (Ploidies)\tAdenocarc., metastatic NOS (ADENOMAS AND ADENOCARCINOMAS)", + "output": "haploidy (Ploidies)" + }, + { + "input": "Definition: something described as one of the possible results of an adverse event outcome that indicates that the event has not improved or recuperated.\nConcepts: EGFR p.L858M (EGFR Protein Variant)\tILF2 Gene (Transcription factor genes)\tBilateral coronal suture synostosis (Skull)\tNOT RECOVERED/NOT RESOLVED (Clinical Course General)\tGrade 2 Urethral Infection, CTCAE (Urethral Infection, CTCAE)", + "output": "NOT RECOVERED/NOT RESOLVED (Clinical Course General)" + }, + { + "input": "Definition: something described as a coded value specifying the anatomic location that is the focus of a study. EXAMPLE(S): breast, ovary\nConcepts: Angioscope (Endoscopes)\tSt. Vituss Dance (Chorea)\tStudyProtocolVersion.targetAnatomicSiteCode (Intellectual Product)\tStage IIIA Squamous Cell Lung Carcinoma (Neoplastic Process)\tProthrombin Fragments 1 + 2 (Laboratory Procedure)", + "output": "StudyProtocolVersion.targetAnatomicSiteCode (Intellectual Product)" + }, + { + "input": "Definition: Cytokine Gene described as this gene plays a role in antiviral responses and JAK-STAT pathway activation.\nConcepts: Made Final Selection of My Treatment After Seriously Considering Doctor's Opinion (Intellectual Product)\tCDISC SDTM Model Version 1.7 (Intellectual Product)\tStage IIIA Cancer of Testis (stage III testicular cancer)\tinterferon lambda 4 (Gene or Genome)\tStrain Substrain Details (Details)", + "output": "interferon lambda 4 (Gene or Genome)" + }, + { + "input": "Definition: something described as acute Iritis: inflammation of the iris, usually marked by pain, photophobia, constriction of the pupil, and a flair of scleral erythema surrounding the iris. It is best diagnosed by a slit lamp examination. In JRA there may be little discomfort.\nConcepts: brown fat cell proliferation (fat cell proliferation)\tShort stature, nail dysplasia, marginal palmoplantar keratoderma, oral hyperpigmentation syndrome (Congenital anomaly of nail)\tcichorium intybus/chicory/wi (Flower Essences)\tAcute anterior uveitis or iridocyclitis or hypopyon (Disease or Syndrome)\tCapnocytophaga, NOS (Non-photosynthetic, non-fruiting gliding bacteria)", + "output": "Acute anterior uveitis or iridocyclitis or hypopyon (Disease or Syndrome)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in).\nConcepts: Influenza-bacillus (Hemophilus)\tNUANCE protein, human (Structural protein)\tpolyamine porter activity (polyamine transmembrane transporter activity)\t9q22.3 (Chromosome band)\tPhytochrome, PhyA (Protein-Serine-Threonine Kinases)", + "output": "polyamine porter activity (polyamine transmembrane transporter activity)" + }, + { + "input": "Definition: alanine-oxo-acid transaminase activity described as catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate.\nConcepts: GCS01-Confounder: Hypoxia/Hypotension (GCS NINDS Version Clinical Classification Question)\tPENCLOMEDINE (Organic Chemical)\talanine aminotransferase activity (alanine-oxo-acid transaminase activity)\tIVD Test Reagent/Kits, Serology, Rapid Test, Virus, Cytomegalovirus (IVD Test Reagent/Kits, Serology, Rapid Test, Virus)\tHomework, function (Teaching & Teaching Methods)", + "output": "alanine aminotransferase activity (alanine-oxo-acid transaminase activity)" + }, + { + "input": "Definition: Organism Function described as functions related to the force generated by the contraction of specific and isolated muscles and muscle groups.\nConcepts: regulation of toll-like receptor 5 signalling pathway (Physiologic Function)\tTIMI 3 (Finding)\tPower of isolated muscles and muscle groups (Muscle power functions)\tVertexometers (Ophthalmological Equipment and Supplies)\tPhysical Examination Location (Finding)", + "output": "Power of isolated muscles and muscle groups (Muscle power functions)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with interleukin-11.\nConcepts: rRNA (guanine) methyltransferase activity (Genetic Function)\tIL-11 (Growth Factor Binding)\tCSS0210 (C-SSRS Since Last Visit Questionnaire Question)\tWestern Ragweed Pollen IgG Measurement (Laboratory Procedure)\tZ-Average (Quantitative Concept)", + "output": "IL-11 (Growth Factor Binding)" + }, + { + "input": "Definition: Bacterium described as a species of obligately-anaerobic, non-spore-forming, Gram-negative bacillus-shaped bacteria in the phylum Bacteroidetes. This species is part of the indigenous bacterial flora in the oral cavity of humans and animals.\nConcepts: Pressure Transducer Domes (Medical Device)\tlongitudinal sarcoplasmic reticulum lumen (sarcoplasmic reticulum lumen)\tPORPHYROMONAS BENNONIS (Bacterium)\tDNA replication initiation involved in meiotic DNA replication (meiotic cell cycle process)\tinfection by Ancylostoma braziliense (Ancylostomiasis)", + "output": "PORPHYROMONAS BENNONIS (Bacterium)" + }, + { + "input": "Definition: something described as a minimally invasive procedure in which a surgeon performs tumor resection through the mouth using a microscope for visualization and a CO2 laser for incisions.\nConcepts: GGDP Synthase (Alkyl and Aryl Transferases)\tplasmodesmatal plasma membrane (Cell Component)\tCEA/Tetanus Toxoid T Helper Epitope Fusion Protein-Expressing DNA Plasmid Vaccine (Cancer Vaccines)\tTLM (Laser Surgery)\tDispensers, Drug, Pill, Unit-Dose, Programmable (Medical Device)", + "output": "TLM (Laser Surgery)" + }, + { + "input": "Definition: Immunologic Factor described as exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription.\nConcepts: membrane protein positioning (establishment of protein localization to membrane)\tprotein location to meiotic spindle pole body (Cell Function)\tNo Problem Detected (Finding)\tCytotoxic Lymphocyte Maturation Factor (cytokine)\tdown regulation of cardiac chamber morphogenesis (Physiologic Function)", + "output": "Cytotoxic Lymphocyte Maturation Factor (cytokine)" + }, + { + "input": "Definition: Somatic dysfunction of rib described as a somatic dysfunction usually characterized by a rib being held in a position of inhalation such that motion toward inhalation is more free and motion toward exhalation is restricted. Synonyms: inhaled rib, anterior rib, inhalation strain, elevated rib, exhalation restriction.\nConcepts: double-stranded DNA exodeoxyribonuclease activity (exodeoxyribonuclease activity, producing 5'-phosphomonoesters)\tBGORRES (Finding)\tElevated rib (Finding)\tEndopeduncular nucleus (Body Part, Organ, or Organ Component)\tt(4;11) (Chromosomal translocation)", + "output": "Elevated rib (Finding)" + }, + { + "input": "Definition: Biospecimen Collection described as any of various methods or devices to allow an individual to collect their own sample for detection of human papillomavirus DNA.\nConcepts: response to anisomycin (Cell Function)\tOAB-q Short Form (Intellectual Product)\tHuman Papillomavirus Self-Collection (Diagnostic Procedure)\tMNSI1-Total Score (MNSI Questionnaire Question)\tAdenoid Cystic Carcinoma of the Lacrimal Gland (carcinoma of lacrimal gland)", + "output": "Human Papillomavirus Self-Collection (Diagnostic Procedure)" + }, + { + "input": "Definition: B-Cell Differentiation described as the process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.\nConcepts: posterior neuropore closure (morphogenesis of embryonic epithelium)\tAnterior Surface of the Stomach (Region of surface of stomach)\tEnd time (Time)\tProline-Rich Proteins, Salivary (Amino Acid, Peptide, or Protein)\tmature B lymphocyte differentiation (B-Cell Differentiation)", + "output": "mature B lymphocyte differentiation (B-Cell Differentiation)" + }, + { + "input": "Definition: Embryonic Structure described as an embryological structure composed of epithelial cells surrounded by mesenchyme that gives rise, in the male, to the prostate gland.\nConcepts: bilberry (Vaccinium)\tAerococcus (Catalase-negative Gram-positive coccus)\tLAMPS, MICROSCOPE (Medical Device)\tPROSTATIC RUDIMENT (Other Embryologic Structure)\tCAG codon-amino acid adaptor activity (Genetic Function)", + "output": "PROSTATIC RUDIMENT (Other Embryologic Structure)" + }, + { + "input": "Definition: Oncogenes described as mutated forms of G-protein genes which encode a diverse group of regulatory proteins that act as molecular switches. Under normal cellular conditions, the activity of these proteins is tightly controlled. Activation of G-protein proto-oncogenes via mutation results in G-protein oncogenes. These aberrant genes express protein products that disrupt normal cell function.\nConcepts: 8-Core Prostate Biopsy (Diagnostic Procedure)\tHEAVY CHAIN DIS (Neoplastic Process)\tClinical Document (Clinical report)\tAbsent shoulder blade (Aplasia/Hypoplasia of the scapulae)\tOncogenes, G-Proteins (Gene or Genome)", + "output": "Oncogenes, G-Proteins (Gene or Genome)" + }, + { + "input": "Definition: Quantitative Concept described as that proportion of disease in the whole population that can be ascribed to the risk factor of concern.\nConcepts: Cockayne syndrome type C (Cockayne Syndrome)\tSerum Carcinoembryonic Antigen Measurement (Carcinoembryonic antigen measurement)\tSDMT01TC (Intellectual Product)\tPopulation-Attributable Risk (Quantitative Concept)\tCoagulation Factor Alteration (Cell Function)", + "output": "Population-Attributable Risk (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as expanded Disability Rating Scale - Postacute Interview Survivor Version - Do you understand what eating or feeding utensils or equipment are for and how they should be used?\nConcepts: ED2-Understand Feeding Utensils (Intellectual Product)\tFACT/GOG-NTX Version 4 Questionnaire Question (Intellectual Product)\tNuclear pore (Part of nuclear wall)\tEC 6.3.2.25 (Ligase)\tRatios, Waist-Hip (Body measure result)", + "output": "ED2-Understand Feeding Utensils (Intellectual Product)" + }, + { + "input": "Definition: Mesothelioma, Cystic described as a rare benign tumor characterized by the formation of intra-abdominal multilocular cystic masses. It occurs more frequently in women of child-bearing age. In women, the masses are generally located on the peritoneal surface of the uterus and rectum, while in men they are generally located on the peritoneal surface of the bladder and rectum. The tumor can also spread into the upper portions of the peritoneal cavity. Appears to originate from the peritoneal mesothelium.There is no relation with asbestos exposure. Invasive or malignant progression has been described.\nConcepts: syndrome; meconium plug (Neonatal gastrointestinal disorder)\tDihydropyrimidine Dehydrogenase Protein Variant (Gene Product Sequence Variation)\tSD-01-filgrastim (Colony-Stimulating Factors)\tBenign multicystic peritoneal mesothelioma (Peritoneal Mesothelioma)\t10^3.{copies}/mL (cpy/mL)", + "output": "Benign multicystic peritoneal mesothelioma (Peritoneal Mesothelioma)" + }, + { + "input": "Definition: Hormones described as substances secreted by neurons into the blood, CNS, or intercellular space.\nConcepts: acrofrontofacionasal dysostosis syndrome 1 (Disease or Syndrome)\tneurohormone (neuroactive substances)\tEnd Expiratory Pause (Pulmonary function tests)\tPlatelet count (Hematology procedure)\tTumor Reoccurrence Unknown After Initial Treatment (CPTAC Responses)", + "output": "neurohormone (neuroactive substances)" + }, + { + "input": "Definition: something described as bladder cancer in which the lymph nodes cannot be assessed.\nConcepts: isatin (Organic Chemical)\tChromosome Aberration, Sex (Chromosomal abnormalities, gene alterations and gene variants)\tBladder Carcinoma pNX TNM Finding v8 (Bladder Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tCDISC Questionnaire SWLS Test Name Terminology (CDISC Questionnaire Terminology)\tendocrine Lloyd's syndrome (Autoimmune endocrine disease)", + "output": "Bladder Carcinoma pNX TNM Finding v8 (Bladder Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: TCF Transcription Factors described as a TCF transcription factor that was originally identified as a DNA-binding protein that interacts with the enhancers of T-CELL RECEPTOR ALPHA GENES. It plays a role in T-LYMPHOCYTE development.\nConcepts: Helicobacter pylori Antigen (Microbiology procedure)\tGrade 1 Testicular Hemorrhage, CTCAE (Finding)\tThymic Atypical Carcinoid Tumor (Atypical carcinoid tumor)\tTranscription Factor 7 (Biologically Active Substance)\tLipohemarthrosis (Pathologic Function)", + "output": "Transcription Factor 7 (Biologically Active Substance)" + }, + { + "input": "Definition: FACT-HEP Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 (FACT-HEP Version 4) Additional Concerns: I am losing weight.\nConcepts: neither good or bad (Finding)\tFAC01529 (Intellectual Product)\tDnaA-oriC complex (primosome complex)\tHaemophilus influenzae, beta lactamase negative (Bacterium)\t10E12 Cells/L (Quantitative Concept)", + "output": "FAC01529 (Intellectual Product)" + }, + { + "input": "Definition: Limb structure described as leg shortening because of underdevelopment of one or more bones of the lower extremity.\nConcepts: TSCC01-My Mind Going Empty or Blank (Intellectual Product)\thypoplasia; limb, lower (Reduction deformity of lower limb)\tfamily characteristics (Socioeconomic Factors)\tBiological terrain analysis each test (General laboratory tests)\tschool learning (Academic Learning & Achievement)", + "output": "hypoplasia; limb, lower (Reduction deformity of lower limb)" + }, + { + "input": "Definition: something described as carts that include special structures designed for concealed transportation of a cadaver; they are also used for temporary storage of cadavers in the morgue. These carts may include special covers and/or a cadaver carrier under the surface of the cart. The cart resembles an empty stretcher while transporting the concealed body. Concealed cadaver carts are used to move deceased patients throughout a healthcare facility without disturbing patients, personnel, or visitors; they are not appropriate to perform autopsies or other post-mortem procedures.\nConcepts: auditory (Functional Concept)\tCovered Cadaver Carts (Carts, Storage/Transport, Cadaver)\tVaginal Carcinoma FIGO Stage I (Finding)\tFGD4 Gene (Gene or Genome)\tAnti-Mullerian Hormone Measurement (Laboratory Procedure)", + "output": "Covered Cadaver Carts (Carts, Storage/Transport, Cadaver)" + }, + { + "input": "Definition: positive regulation of extrinsic apoptotic signaling pathway described as any process that activates or increases the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand.\nConcepts: Depolymerizing Factors, Actin (Biologically Active Substance)\tspherocyte (Red blood cell shape)\tPteridinones (Organic Chemical)\tHAQ02-Othr Aid (HAQ-DI Without VAS Questionnaire Question)\tpositive regulation of extrinsic apoptotic signalling pathway in absence of ligand (Molecular Function)", + "output": "positive regulation of extrinsic apoptotic signalling pathway in absence of ligand (Molecular Function)" + }, + { + "input": "Definition: something described as an infectious disease that occurs in infancy, childhood, or adolescence.\nConcepts: Tet Oncogene Family Member 2 Loss (Laboratory or Test Result)\tFACT/GOG-NTX Version 4 - I Feel Weak All Over (FACT/GOG-NTX Version 4 Questionnaire Question)\tPoverty Areas (Poverty)\tPediatric Infectious Disease (Communicable Diseases)\tMy desire for sexual intimacy (Intellectual Product)", + "output": "Pediatric Infectious Disease (Communicable Diseases)" + }, + { + "input": "Definition: something described as endonucleolytic cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA.\nConcepts: 8q22-q23 (Cell Component)\tERG2 (Amino Acid, Peptide, or Protein)\tendonucleolytic tRNA 3'-end cleavage (Genetic Function)\tDelayed ability to roll over (Gross motor development delay)\tisoleucine N-monooxygenase (oxime forming) activity (Molecular Function)", + "output": "endonucleolytic tRNA 3'-end cleavage (Genetic Function)" + }, + { + "input": "Definition: something described as surgery to completely remove the larynx.\nConcepts: kp (Quantitative Concept)\tLARYNGECTOMY TOTAL (Complete excision)\tDocosadienoic Acid (Very long chain fatty acid)\tMumps Measles Rubella Vaccine (VaccineType)\tVOLUMETRIC/MANOMETRIC, CARBON-DIOXIDE (Medical Device)", + "output": "LARYNGECTOMY TOTAL (Complete excision)" + }, + { + "input": "Definition: Intellectual Product described as records detailing the type biological specimen being exported.\nConcepts: positive regulation of branching involved in lung morphogenesis (positive regulation of animal organ morphogenesis)\tSample Expt Docn (Intellectual Product)\tnitrate reductase (oxidoreductase activity, acting on other nitrogenous compounds as donors)\tFACT/GOG-NTX Version 4 - I Have Pain (FACT/GOG-NTX Version 4 Questionnaire Question)\tPelvic Declination (Body position)", + "output": "Sample Expt Docn (Intellectual Product)" + }, + { + "input": "Definition: something described as a subjective score of 4 on a scale that ranges from 1: Strongly Disagree to 6: Strongly Agree.\nConcepts: Hedeoma pulegioides, homeopathic preparation (Homeopathic remedies letter H)\tAgreement Rating Score 4 (Finding)\tNewfoundland dog (Dog family)\tRefractory Glioblastoma (Refractory Malignant Glioma)\tAlteration in patterns of urinary elimination (Urinary Elimination Component)", + "output": "Agreement Rating Score 4 (Finding)" + }, + { + "input": "Definition: something described as the sexual attraction or relationship between members of both the same and the opposite SEX.\nConcepts: AVL01-List A Recall 6 (After B) Word 5 (Intellectual Product)\tBisexuality (Sexuality issues)\tPSA Levels Greater than 2.5 (Laboratory or Test Result)\tADL03-Keep Appointments (ADCS-ADL MCI Questionnaire Question)\tANSD0101 (Intellectual Product)", + "output": "Bisexuality (Sexuality issues)" + }, + { + "input": "Definition: Nutrition, Dietary Components described as role of trace elements in cancer causation or prevention and in general health.\nConcepts: Trace Nutrients (Research Activity)\tlipopolysaccharide (Glycoconjugates)\tcardiac muscle cell action potential (Cell Function)\tTSCYC142 (Intellectual Product)\tThis Doctor Knows Me Well as a Person (Clinical or Research Assessment Question)", + "output": "Trace Nutrients (Research Activity)" + }, + { + "input": "Definition: something described as this gene may play a role in the regulation of both ion channels and ubiquitination.\nConcepts: Q-LES-Q-SF (Intellectual Product)\tpositive regulation of exonucleolytic catabolism of deadenylated mRNA (regulation of exonucleolytic catabolism of deadenylated mRNA)\tIslet Cell 512 Antibody Measurement (Laboratory Procedure)\tC20orf188 (Gene or Genome)\tWD6H4 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", + "output": "C20orf188 (Gene or Genome)" + }, + { + "input": "Definition: receptor described as c-type mannose receptor 2 (1479 aa, ~167 kDa) is encoded by the human MRC2 gene. This protein is involved in remodeling of the extracellular matrix and may play a role in the tumorigenesis and metastasis.\nConcepts: Have Weight Loss Problem (Findings-Based Question)\tMacrophage Mannose Receptor 2 (Amino Acid, Peptide, or Protein)\tRisk For Perioperative Injury (Safety)\tNonencapsulated sclerosing tumour (Neoplastic Process)\tcoenzyme A transmembrane transporter activity (coenzyme transmembrane transporter activity)", + "output": "Macrophage Mannose Receptor 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as health insurance providing benefits to cover or partly cover hospital expenses.\nConcepts: Hospitalization Insurance (Health Care Activity)\tComprehensive new wellness 60 minutes (New client wellness visit with or without ICD diagnosis)\tAlpha Particle Emitter (Element, Ion, or Isotope)\tTyrosine Kinase Inhibitor XL228 (Protein-tyrosine kinase inhibitor)\tregulation of prostaglandin secretion (regulation of signaling)", + "output": "Hospitalization Insurance (Health Care Activity)" + }, + { + "input": "Definition: Gene or Genome described as human L1CAM wild-type allele is located in the vicinity of Xq28 and is approximately 48 kb in length. This allele, which encodes neural cell adhesion molecule L1 protein, is involved in neuron-neuron cell adhesion, axon guidance and bundling of neurons. Mutation of the gene is associated with hydrocephalus due to stenosis of the aqueduct of Sylvius (HSAS), mental retardation, aphasia, shuffling gait, and adducted thumbs syndrome (MASA or CRASH syndrome), spastic paraplegia 1, X-linked and agenesis of the corpus callosum, X-linked, partial and may contribute to intestinal aganglionosis in Hirschsprung disease.\nConcepts: Ganglionectomies (Denervation)\tAmino Acid (Nitrogen and nitrogen compound)\tChemical Warfare Agents (Poisons)\tSlightly False (Clinical or Research Assessment Answer)\tN-CAML1 (L1CAM gene)", + "output": "N-CAML1 (L1CAM gene)" + }, + { + "input": "Definition: IL5RA gene described as human IL5RA wild-type allele is located within 3p26-p24 and is approximately 41 kb in length. This allele, which encodes interleukin-5 receptor subunit alpha protein, is involved in transcriptional mediation and cytokine regulation.\nConcepts: Anophthalmia Waardenburg syndrome (Eye Abnormalities)\tPD-1/PD-L1 Antibody-producing T cells (Chimeric Antigen Receptor T-cells)\tDeaminase, Deoxycytidine Monophosphate (Enzyme)\tCDw125 (IL5RA gene)\tANISOMETROPIA (Disorder of refraction AND/OR accommodation)", + "output": "CDw125 (IL5RA gene)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a benzoic acid stimulus.\nConcepts: response to benzoic acid (Cell Function)\tcadaverine transport (nitrogen compound transport)\tDesoxyephedrine hydrochloride (Hazardous or Poisonous Substance)\tDorsum of abdomen (Lumbar Region)\tcell wall hydroxyproline-rich glycoprotein metabolic process (Molecular Function)", + "output": "response to benzoic acid (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Toddler Parent Report - In the past one month, how much of a problem has this been for your child: It takes my child a long time to bathe or shower.\nConcepts: Stage IV Head and Neck Squamous Cell Cancer (Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage)\tDeficiency, N-Laurylsphingosine Deacylase (Rare Non-Neoplastic Disorder)\tPlacental Proteins (Endocrine system)\tporosome (Cell Component)\tPQL0913 (Intellectual Product)", + "output": "PQL0913 (Intellectual Product)" + }, + { + "input": "Definition: Carcinoma of extrahepatic bile duct described as the reemergence of an extrahepatic bile duct carcinoma after a period of remission.\nConcepts: glycerate transmembrane transport (Cell Function)\tbile duct cancer, recurrent extrahepatic (Carcinoma of extrahepatic bile duct)\tCircumferences, Waist (abdominal inspection)\tSoft Tissue Sarcoma of the Trunk and Extremities pN1 TNM Finding v8 (Finding)\tAntidiuretic Hormone Analogue (Therapeutic Hormone)", + "output": "bile duct cancer, recurrent extrahepatic (Carcinoma of extrahepatic bile duct)" + }, + { + "input": "Definition: FACT-LEU Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Leukemia Version 4 - Additional Concerns: I am losing weight.\nConcepts: L-xylulose reductase (NAD+) activity (Molecular Function)\telectronystagmogram (Ophthalmological test)\tCACREAT (Calcium measurement)\tCytosolic NADP-Isocitrate Dehydrogenase Protein Arg132His Negative (Laboratory or Test Result)\tFAC01737 (FACT-LEU Version 4 Questionnaire Question)", + "output": "FAC01737 (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Philosophy described as branch of philosophy concerned with the fundamental nature of things and existence.\nConcepts: VFQ1-Difficulty Reading Street Signs (VFQ25-Interviewer Administered Format Questionnaire Question)\tlachnanthes tinctoria/spirit (Homeopathic remedies letter L)\tSTOCKING, MEDICAL SUPPORT (Device associated with venous compression systems)\tmetaphysics (Occupation or Discipline)\tSFMP2 (Clinical or Research Assessment Questionnaire)", + "output": "metaphysics (Occupation or Discipline)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as axons of certain cells in the DENTATE GYRUS. They project to the polymorphic layer of the dentate gyrus and to the proximal dendrites of PYRAMIDAL CELLS of the HIPPOCAMPUS. These mossy fibers should not be confused with mossy fibers that are cerebellar afferents (see NERVE FIBERS).\nConcepts: posterior horn (Neuroanatomy)\tAlzheimer's Disease Cooperative Study-Activities of Daily Living Inventory Mild Cognitive Impairment Questionnaire (Intellectual Product)\thippocampal mossy fiber (Structure of dentate gyrus)\tMICRO YUCATAN MINIATURE SWINE (Mammal)\tnational institute mental health (Component of the National Institutes of Health)", + "output": "hippocampal mossy fiber (Structure of dentate gyrus)" + }, + { + "input": "Definition: Human Factors Issue Associated with Medical Device described as problem associated with failure to process, service, or operate the device according to the manufacturer's recommendations or recognized best practices.\nConcepts: I feel a throat obstacle during swallowing (Clinical or Research Assessment Question)\t12: 64504458-64646266 (Chromosome 12 Physical Location)\tUse of Device Problem (Medication errors, product use errors and issues NEC)\tTwin pregnancy NOS (Female Reproductive System Finding)\tendemic polyneuritis (Thiamine and niacin deficiency states)", + "output": "Use of Device Problem (Medication errors, product use errors and issues NEC)" + }, + { + "input": "Definition: Radiation injury described as congenital changes in the morphology of organs produced by exposure to ionizing or non-ionizing radiation.\nConcepts: ABRAXAS1 Gene Mutation (Cell or Molecular Dysfunction)\t2 Ala 4 MePhe 5 Gly Enkephalin (Amino Acid, Peptide, or Protein)\tAbnormality, Radiation-Induced (Injury or Poisoning)\tMBSTRESN (Numeric Test Result)\tHYPERAMMONAEMIA (Pathologic Processes)", + "output": "Abnormality, Radiation-Induced (Injury or Poisoning)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by Diener et al in 1985, which is used to measure global cognitive judgments of satisfaction with one's life. The questionnaire contains 5 questions and is scored ranging from 1 (Strongly disagree) to 7 (Strongly agree).\nConcepts: diplegia (Nerve palsy)\tIntraductal Lesion (Finding)\tretinol binding protein 4 (Gene or Genome)\tHerpes, Other Than Genital Virus (Classification)\tSatisfaction With Life Scale Questionnaire (Intellectual Product)", + "output": "Satisfaction With Life Scale Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Adverse Event by CTCAE v4 Severity Grade described as an adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).\nConcepts: CTCAE v4 Grade 2 (Finding)\tattenuation (Action)\tClinical Trials, Diagnosis (Trial Indication Type)\tSRTESTCD (Test Code)\tLong-Term Care Insurance (Health Insurance)", + "output": "CTCAE v4 Grade 2 (Finding)" + }, + { + "input": "Definition: Coagulation factor deficiency syndrome described as a coagulation disorder characterized by the partial or complete absence of prothrombin (factor II) activity in the blood.\nConcepts: Biological Process Has Result Biological Process (NCI Thesaurus Role)\tcell pole (cellular anatomical entity)\tFactor II Deficiency (Disease or Syndrome)\tPRICKLE1 Gene (Signaling Pathway Gene)\tmorphogenesis of an epithelium (Organ or Tissue Function)", + "output": "Factor II Deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a syndrome of congenital cataracts, hydrophthalmia, delayed growth and mental development, vitamin D-resistant rickets, aminoaciduria, and reduced production of ammonia by the kidneys. Additional manifestations include areflexia, hypotonia, glaucoma, corneal keloid, and noninflammatory arthropathy.\nConcepts: dA dT, Poly (Polydeoxyribonucleotides)\tholo-[acyl-carrier-protein] biosynthesis (macromolecule biosynthetic process)\tcaprolactam metabolic process (organonitrogen compound metabolic process)\tmusic therp grp ea.h (Therapeutic or Preventive Procedure)\tdystrophy; oculocerebrorenal (Congenital eye disorders NEC)", + "output": "dystrophy; oculocerebrorenal (Congenital eye disorders NEC)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the side of the body (or a paired organ) that is an access point for a observation. EXAMPLE(S): bilateral, left, right OTHER NAME(S): NOTE(S): This attribute was deprecated in BRIDG 3.1 but undeprecated in 4.0 since source use cases for separate laterality include SDTM and CTOM. This change ensures that users of the BRIDG model are not bound to a particular kind of vocabulary, such as pre- or post-coordinated vocabularies. Collapsing laterality into the target site code is an implementation option.\nConcepts: PerformedObservation.approachAnatomicSiteLateralityCode (Approach Anatomic Site Laterality Code)\tDistress over Family Problem of Dealing with Children (Findings-Based Question)\tLEC0117B (Intellectual Product)\tntraplrl tube nsrxn 4subst a (Substance administration management)\tSoft Tissue Sarcoma pT0 TNM Finding v7 (Finding)", + "output": "PerformedObservation.approachAnatomicSiteLateralityCode (Approach Anatomic Site Laterality Code)" + }, + { + "input": "Definition: Intellectual Product described as a character or string used to name, or characterize a microbiology susceptibility reference.\nConcepts: myelin sheath (Cell appendage)\tNucleic acid hybridization, function (Genetic Techniques)\tMSREFID (Intellectual Product)\tVirion (virus characteristic)\tHealth, Suburban (Health)", + "output": "MSREFID (Intellectual Product)" + }, + { + "input": "Definition: something described as dental caries involving a discrete area of tooth not including an existing restoration.\nConcepts: Software, Stereotactic System, Image-Guided Radiosurgery (Intellectual Product)\tNCI-H23 (NCI-60 Cell Line)\tPrimary caries (Caries)\tFGF3 (Biologically Active Substance)\tExcepted from Direct Marking (Status)", + "output": "Primary caries (Caries)" + }, + { + "input": "Definition: something described as impact of Visual Impairment Scale - During the past 4 weeks, how difficult did you find it to read or access dials, such as on stoves, thermostats, etc.?\nConcepts: Inherited predisposition to essential thrombocythemia (Thrombocythemia, Essential)\tAnatomical junction, NOS (Anatomical cluster)\tTissue Culture Infection Dose (Quantitative Concept)\tAnti-immunoglobulin (Ig) and Immunoreceptor Tyrosine-based iInhibitory Motif Monoclonal Antibody (Amino Acid, Peptide, or Protein)\tIVIS01-Read or Access Dials (Intellectual Product)", + "output": "IVIS01-Read or Access Dials (Intellectual Product)" + }, + { + "input": "Definition: something described as mild or intermittent change from normal voice\nConcepts: dendrobium/shi hu (Plant)\tPain Interference Score 3 (Intellectual Product)\tGrade 1 Voice Alteration, CTCAE (Finding)\tbenzoate catabolism (aromatic compound catabolic process)\tRefractory Atypical Teratoid/Rhabdoid Tumor (Neoplastic Process)", + "output": "Grade 1 Voice Alteration, CTCAE (Finding)" + }, + { + "input": "Definition: mRNA Degradation described as the chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells.\nConcepts: Division of Lung Diseases (Health Care Related Organization)\tPSIP1 Gene Product (Amino Acid, Peptide, or Protein)\tnuclear mRNA degradation (mRNA Degradation)\tHYPERPITUITARISM (Hyperpituitarism)\tchamomilla matricaria/german (Oils, Volatile)", + "output": "nuclear mRNA degradation (mRNA Degradation)" + }, + { + "input": "Definition: Indicator described as an indication as to whether there is doming of a cardiac valve cusp.\nConcepts: Adult-onset immunodeficiency with anti-interferon-gamma autoantibodies (Adult-onset immunodeficiency)\tFACT-LEU Version 4 - Able to Do My Usual Activities (FACT-LEU Version 4 Questionnaire Question)\tregulation of lipid binding (regulation of binding)\tMy decision shows what is important to me (Clinical or Research Assessment Question)\tCSPDIND (Indicator)", + "output": "CSPDIND (Indicator)" + }, + { + "input": "Definition: something described as a stack of flattened vesicles located between the nucleus and the secretory pole or surface of a cell. Functions in posttranslational processing and sorting of proteins, receiving them from the rough endoplasmic reticulum and directing them to secretory vesicles, lysosomes, or the cell membrane. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or golgi apparatus and fuse with the golgi, lysosomes or cell membrane.\nConcepts: Insufficient Heating (Temperature Problem)\tGolgi apparatus (Cell Component)\tPapilloma (Disease of Skin and Appendages)\tablactation (infant nutrition)\tBurkholderia cepacia complex (Bacterium)", + "output": "Golgi apparatus (Cell Component)" + }, + { + "input": "Definition: something described as a large highly-conserved family of ATPases with diverse functions in cells that are characterized by the presence of a P-LOOP and a ring shape. They couple the energy generated by ATP hydrolysis to remodeling or mechanical translocation of their target molecules.\nConcepts: Readiness Score 2 (Finding)\tMedical Inspection (Health Care Activity)\tATPases Associated with Diverse Cellular Activities (Adenosine Triphosphatases)\tImagings, Ultrasound (MISCELLANEOUS DIAGNOSTIC AND THERAPEUTIC PROCEDURES)\tSubstantially compromised occlusal scheme (Dental occlusion finding)", + "output": "ATPases Associated with Diverse Cellular Activities (Adenosine Triphosphatases)" + }, + { + "input": "Definition: Trees and shrubs described as a plant family of the order Celastrales, subclass Rosidae, class Magnoliopsida.\nConcepts: Membranous Canal of the Cochlea (Cell Component)\tAldehyde Dehydrogenase Blockers (Pharmacologic Substance)\tfemale gametophyte central cell differentiation (Cell Function)\tFamily Celastraceae (Phylogenetic group 10)\tAcquired Fanconi Syndrome (Metabolic acidoses)", + "output": "Family Celastraceae (Phylogenetic group 10)" + }, + { + "input": "Definition: something described as an ~60 amino acid extracellular protein domain that contains a conserved tryptophan and four invariant cysteines (Cys), where Cys 1 and Cys 3 form one disulfide bridge and Cys 2 and Cys 4 form another. The tertiary structure for sushi domains is based on a beta-sandwich, where one face is made up of three beta-strands that are hydrogen-bonded forming a central hydrophobic triple-stranded region and the other face is comprised of two additional beta-strands.\nConcepts: History of recent animal bite (Finding)\therpes zoster (Alphaherpesvirinae)\tfibroblast migration (Cell Function)\tMoraxella (subgen. Moraxella Lwoff 1939) nonliquefaciens (Scarlett 1916) Bovre 1984 (Bacterium)\tShort Consensus Repeat (Protein Binding Motif)", + "output": "Short Consensus Repeat (Protein Binding Motif)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in excretion of toxic electrolytes.\nConcepts: regulation of mRNA export from nucleus during heat stress (regulation of cellular response to heat)\tAlpha-2-Plasmin Inhibitor (Serine Proteinase Inhibitors)\ttellurium (Metalloids)\tNSA0107 (Intellectual Product)\tMATE2-K (Transport Protein Gene)", + "output": "MATE2-K (Transport Protein Gene)" + }, + { + "input": "Definition: Protein Binding Motif described as the approximately 70 amino acid SAM (Sterile Alpha Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein-protein interaction via the formation of homo and hetero-typic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined.\nConcepts: Sterile Alpha Domain (Amino Acid Motifs)\tAnti-progesterones (Pharmacologic Substance)\tINULIN (Oligosaccharides)\tpositive regulation by symbiont of RNA levels in host (modulation by symbiont of RNA levels in host)\tI-SMAD binding (SMAD binding)", + "output": "Sterile Alpha Domain (Amino Acid Motifs)" + }, + { + "input": "Definition: Gram Negative Bacteria described as any bacterial organism that can be assigned to the species Francisella tularensis.\nConcepts: C-terminal peptidyl-cysteine amidation (peptidyl-cysteine modification)\tFrancisella tularense (Francisella)\tInfection, Aliivibrio (Disease or Syndrome)\tSET, TRANSFER (Medical Device)\tMultiple Nucleotide Abnormalities (Mutation Abnormality)", + "output": "Francisella tularense (Francisella)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subclass of purinergic P2 receptors whose signaling is coupled through a G-PROTEIN signaling mechanism.\nConcepts: I have no problem with my shoulder (Intellectual Product)\tP2Y Purinoceptors (Receptors, Purinergic P2)\tRetroperitoneal Soft Tissue Sarcoma pT0 TNM Finding v8 (Soft Tissue Sarcoma of the Retroperitoneum Pathologic Primary Tumor TNM Finding v8)\tChildhood Nasal Cavity Carcinoma (Rare Childhood Malignant Neoplasm)\tPhrenic Nerve Palsy, Congenital (Disease or Syndrome)", + "output": "P2Y Purinoceptors (Receptors, Purinergic P2)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the medial basal segment of the inferior lobe of the left lung.\nConcepts: LUNG, LEFT, INFERIOR LOBE, MEDIAL BASAL SEGMENT (Body Part, Organ, or Organ Component)\tEndolymphatic sac (Endolymphatic duct)\tCD210 Antigen (Receptor)\tgoiter nontoxic (Disease or Syndrome)\tpositive regulation of body size (Organism Function)", + "output": "LUNG, LEFT, INFERIOR LOBE, MEDIAL BASAL SEGMENT (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Breast Carcinoma described as a term that refers to the staging of breast cancer, following the rules of the TNM AJCC v8 classification system. It applies to invasive (infiltrating) carcinoma of the breast and ductal carcinoma in situ of the breast. It does not apply to breast sarcoma, phyllodes tumor, and breast lymphoma.\nConcepts: Continuing Education (Adult education)\tBreast Cancer by AJCC v8 Stage (Neoplastic Process)\tPolyamine Compound (Organic Chemical)\tSchool Health Nursing (Community Health Nursing)\tSTUMP (Melanocytic nevus)", + "output": "Breast Cancer by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Genetic finding described as a finding indicating that there is no information regarding the presence or absence of IDH1 or IDH2 gene mutations in a tumor sample.\nConcepts: negative regulation of serine-type peptidase activity (regulation of serine-type peptidase activity)\themotoxin (Toxin)\tScrotal Pain (Finding)\ttoxic encephalopathy hyperammonemic due to carbonic anhydrase va deficiency (Hyperammonemic encephalopathy)\tIDH Gene Family Mutation Status Unknown (Laboratory or Test Result)", + "output": "IDH Gene Family Mutation Status Unknown (Laboratory or Test Result)" + }, + { + "input": "Definition: regulation of isoprenoid metabolic process described as any process that modulates the frequency, rate or extent of ent-pimara-8(14),15-diene biosynthetic process.\nConcepts: deprivation social (Stimulus Deprivation)\tIVD Panels, Human Genetics, Immunodeficiency, Primary, Autoimmune Lymphoproliferative Syndrome (IVD Panels, Human Genetics, Immunodeficiency, Primary)\tregulation of ent-pimara-8(14),15-diene anabolism (regulation of lipid biosynthetic process)\tBrucella abortus brucellosis (Non-human disorder)\tAsbestos fibers, NOS (Lungs and Breathing)", + "output": "regulation of ent-pimara-8(14),15-diene anabolism (regulation of lipid biosynthetic process)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell.\nConcepts: Zoonoses (Bacterial Infections and Mycoses)\tanisotropic cell growth (Cell Growth)\tAtaxy (Abnormal coordination)\tALK NM 004304.4:c.3185A>T (Cell or Molecular Dysfunction)\tBone cell cancer (skeletal neoplasm)", + "output": "anisotropic cell growth (Cell Growth)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: agmatine + H(2)O = putrescine + urea.\nConcepts: HAMD302 (HAMD 24 Clinical Classification Question)\tresponse to parathyroid hormone (Cell Function)\tagmatine ureohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)\tDisease Risk Index High Risk (Intellectual Product)\tMucosal Invasion (Finding)", + "output": "agmatine ureohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines)" + }, + { + "input": "Definition: something described as a transmembrane protein complex located in the ER that is involved in ER-mitochondrial membrane tethering, which is required to facilitate lipid transfer from the ER to the mitochondrial membrane. In S. cerevisiae, it has six members: EMC1, EMC2, AIM27, EMC4, KRE27, and EMC6.\nConcepts: echoPlanarPulseSequenceIndicator (Indicator)\tCPTAC THCA Baseline Form (Intellectual Product)\tdephosphorylation-gated channel activity (gated channel activity)\tER membrane protein complex (Cell Component)\tAmpicillin Resistances (Finding)", + "output": "ER membrane protein complex (Cell Component)" + }, + { + "input": "Definition: glucocorticoid secretion described as the regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland.\nConcepts: Wrist skin (Wrist)\tzinc efflux transmembrane transporter activity (cation efflux transmembrane transporter activity)\tMultipurpose Sponges (Medical Device)\tANTIGEN, RUBELLA, OTHER (Medical Device)\tcortisol secretion (organic hydroxy compound transport)", + "output": "cortisol secretion (organic hydroxy compound transport)" + }, + { + "input": "Definition: Enzyme described as sulfhydryl oxidase 2 (698 aa, ~78 kDa) is encoded by the human QSOX2 gene. This protein plays a role in the oxidation of sulfhydryl groups to disulfides in extracellular peptides and proteins.\nConcepts: SPRING (Seasons)\tGonadotropin-Releasing Hormone Signaling Pathway (Functional Concept)\tstage 0is ureter urothelial carcinoma AJCC v8 (Neoplastic Process)\tQuiescin Sulfhydryl Oxidase 2 (Amino Acid, Peptide, or Protein)\tpN1b Melanoma of Skin v6 (Cutaneous Melanoma pN1 TNM Finding v6)", + "output": "Quiescin Sulfhydryl Oxidase 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Poisoning, Toxicology, Environmental Health described as any part of a signal that is not the true or original signal but is introduced by the communication mechanism.\nConcepts: Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs (Gonadal Dysgenesis)\tData Noise (Environmental Pollution)\tDid Caregiving Responsibilities Make it Difficult to Get Going Easily at Beginning of Workday (Intellectual Product)\tPerformed Medical History Result Occurrence Date Range (Temporal Concept)\tFAQ02-Playing a Game of Skill (Intellectual Product)", + "output": "Data Noise (Environmental Pollution)" + }, + { + "input": "Definition: Speech & Language Disorders described as the inability to recognize a familiar face or to learn to recognize new faces. This visual agnosia is most often associated with lesions involving the junctional regions between the temporal and occipital lobes. The majority of cases are associated with bilateral lesions, however unilateral damage to the right occipito-temporal cortex has also been associated with this condition. (From Cortex 1995 Jun;31(2):317-29)\nConcepts: PRITBCON (CDISC SDTM Terminology)\tsecondary olfactory cortical area (Body Location or Region)\tFACE BLINDNESS (Physical & Psychosomatic Disorders)\ttelomere dispersion during interphase (Physiologic Function)\tColorectal Cancer Pathologic Primary Tumor TNM Finding v6 (Colorectal Cancer Pathologic TNM Finding v6)", + "output": "FACE BLINDNESS (Physical & Psychosomatic Disorders)" + }, + { + "input": "Definition: Patient or Disabled Group described as a patient is the subject of observations.\nConcepts: Hypopharyngeal Cancer cN2a TNM Finding v8 (Hypopharyngeal Cancer cN2 TNM Finding v8)\tcytoplasmic side of apical plasma membrane (internal side of plasma membrane)\tLAY USER/PATIENT (Treatment (General))\tLate Effects, Prenatal Exposure (Injury or Poisoning)\tregulation of glycolysis through fructose-6-phosphate (Cell Function)", + "output": "LAY USER/PATIENT (Treatment (General))" + }, + { + "input": "Definition: something described as a genus of aerobic, gram negative, coccobacilli shaped bacterium assigned to the phylum Proteobacteria and the family Alcaligenaceae.\nConcepts: Mental Health @ None @ Family Psychotherapy @ Other Family Psychotherapy @ None @ None @ None (Psychiatric therapeutic procedure)\tGLIPR2 gene (Gene or Genome)\tExperiential auras (Sign or Symptom)\tRestriction Enzyme (DNA Restriction-Modification Enzymes)\t226 OLIGELLA (Alcaligenaceae)", + "output": "226 OLIGELLA (Alcaligenaceae)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid.\nConcepts: lysine metabolism (aspartate family amino acid metabolic process)\tCLB/DACT/DOX/DTIC/MTX/VCR (Therapeutic or Preventive Procedure)\tPerihilar Bile Duct Cancer Clinical Distant Metastasis TNM Finding v7 (Perihilar Bile Duct Cancer Clinical TNM Finding v7)\tInvasive Procedure (Therapeutic or Preventive Procedure)\tNut allergy (Nut and Peanut Hypersensitivity)", + "output": "lysine metabolism (aspartate family amino acid metabolic process)" + }, + { + "input": "Definition: Area Under Urinary Excretion Rate Curve described as the area under the urinary excretion rate curve (AURC) extrapolated to infinity, based on the last predicted excretion rate, divided by the body mass index.\nConcepts: Norepinephrine bitartrate (Adrenal medulla hormone)\tComplete duplication of the proximal phalanx of the 5th finger (Anatomical Abnormality)\tAURC Infinity Pred Norm by BMI (Quantitative Concept)\tCatheter Introducers-Hemostasis Valve (Medical Device)\tHBB Protein Variant (Gene Product Sequence Variation)", + "output": "AURC Infinity Pred Norm by BMI (Quantitative Concept)" + }, + { + "input": "Definition: PTK7 gene described as human PTK7 wild-type allele is located within 6p21.1-p12.2 and is approximately 85 kb in length. This allele, which encodes tyrosine-protein kinase-like 7 protein, plays a role in tyrosine kinase signal transduction and may be involved in cellular adhesion.\nConcepts: CCK4 (PTK7 gene)\tCachet (Type of drug preparation)\tMagnetic IONPs (Metal Nanoparticles)\tMotif, Tudor (Protein Interaction Domains and Motifs)\terythronium purpurea/fawn li (Flower Essences)", + "output": "CCK4 (PTK7 gene)" + }, + { + "input": "Definition: something described as catalysis of the reaction: (-)-trans-permethrin + H2O <=> H+ + (3-phenoxyphenyl)methanol + (1S,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate.\nConcepts: calcium ion binding involved in regulation of postsynaptic cytosolic calcium levels (calcium ion binding involved in regulation of cytosolic calcium ion concentration)\tLEC-5 Standard Version - Serious Accident: Learned (LEC-5 Standard Version Questionnaire Question)\tregulation of amniotic stem cell differentiation (regulation of mesenchymal stem cell differentiation)\ttrans-permethrin hydrolase activity (carboxylic ester hydrolase activity)\tSpinal cord terminal ventricle (Spinal Cord)", + "output": "trans-permethrin hydrolase activity (carboxylic ester hydrolase activity)" + }, + { + "input": "Definition: Abnormal buccal mucosa cell morphology described as an anomalous amount or location of cell junction proteins such as plakoglobin or Cx43.\nConcepts: immunoglobulin d (Antibodies)\tAbnormal distribution of cell junction proteins in buccal mucosal cells (Abnormal buccal mucosa cell morphology)\tBone Cancer cM0 TNM Finding v8 (Finding)\tAmphibole asbestos (Inorganic Chemical)\tFoxtail Millets (Plant)", + "output": "Abnormal distribution of cell junction proteins in buccal mucosal cells (Abnormal buccal mucosa cell morphology)" + }, + { + "input": "Definition: Professional or Occupational Group described as clinical Neurophysiology is a subspecialty with psychiatric or neurologic expertise in the diagnosis and management of central, peripheral, and autonomic nervous system disorders using combined clinical evaluation and electrophysiologic testing such as electroencephalography (EEG), electromyography (EMG), and nerve conduction studies (NCS).\nConcepts: Nostrums (Pharmaceutical Preparations)\tcavum septum pellucidum-cavum vergae-macrocephaly-seizures-mental retardation syndrome (Disease or Syndrome)\tPhysicians; Physician/Osteopath; Neurophysiology, Clinical (Professional or Occupational Group)\tESR (Laboratory Procedure)\tALKBH7 Gene (Oxidoreductase Gene)", + "output": "Physicians; Physician/Osteopath; Neurophysiology, Clinical (Professional or Occupational Group)" + }, + { + "input": "Definition: Diagnostic Imaging described as the use of light interaction (scattering, absorption, and fluorescence) with biological tissue to obtain morphologically based information. It includes measuring inherent tissue optical properties such as scattering, absorption, and autofluorescence; or optical properties of exogenous targeted fluorescent molecular probes such as those used in optical MOLECULAR IMAGING, or nontargeted optical CONTRAST AGENTS.\nConcepts: nuclear (Serology)\tHow much did this feeling bother you or trouble you (Intellectual Product)\tImaging, Optical (Diagnostic Procedure)\tsperm banks (Supportive care)\tEwing Sarcoma of Bone (Malignant tumor of bone and articular cartilage)", + "output": "Imaging, Optical (Diagnostic Procedure)" + }, + { + "input": "Definition: axis specification described as the establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.\nConcepts: RecQ Like Helicase 4 Gene Mutation (DNA Repair Gene Mutation)\t2q37.2 (Cell Component)\tWrite Code, Software Platform/Architecture, in Vitro Diagnostics Device (Testing)\tmammary gland alveolus development (Organ or Tissue Function)\tanterior/posterior axis determination (axis specification)", + "output": "anterior/posterior axis determination (axis specification)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of carbohydrate derivative.\nConcepts: positive regulation of gastric acid secretion (regulation of gastric acid secretion)\tHaemophilus parainfluenzae Rivers 1922 (Bacterium)\tanti-FGFR3 monoclonal antibody MFGR1877S (Immunologic Factor)\tcarbohydrate derivative catabolic process (organic substance catabolic process)\tDoses, Maximally Tolerated (Toxicity Tests)", + "output": "carbohydrate derivative catabolic process (organic substance catabolic process)" + }, + { + "input": "Definition: Pharmacologic Substance described as a preparation of lymphocytes harvested from a patient with an Epstein-Barr virus (EBV)-positive tumor. Ex vivo, the lymphocytes are activated against EBV-specific antigens and then returned to the patient, where they mount a specific immune response against EBV-positive tumor cells.\nConcepts: AVSD - Atriovent septal defect (Congenital heart disease)\tAnalysis Dataset (Domain)\tReexploration (Exploration procedure)\tPhotofluorometers (Photometers, Filter)\tEBV-Specific Cytotoxic T-Lymphocytes (therapeutic autologous lymphocytes)", + "output": "EBV-Specific Cytotoxic T-Lymphocytes (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to walk 1 mile nonstop.\nConcepts: positive regulation of lamellipodium morphogenesis (positive regulation of lamellipodium organization)\tCarotid Artery, External (Common carotid artery)\tSuppliers; Indian Health Service/Tribal/Urban Indian Health (I/T/U) Pharmacy (Health Care Related Organization)\tWalking 1 Mile Nonstop (Intellectual Product)\tClinical polymyositis syndrome (Connective Tissue Diseases)", + "output": "Walking 1 Mile Nonstop (Intellectual Product)" + }, + { + "input": "Definition: Bacterium described as a species of Gram-positive, alpha- or beta-hemolytic bacteria in the order Lactobacillales. The species is split into two subspecies, S. dysgalactiae subsp. dysgalactiae and S. dysgalactiae subsp. equisimilis.\nConcepts: nmol/min/mL (Moles per unit time per unit volume)\tCelosias (Plant)\tStreptococcus pseudogalactiae (Streptococcus)\tAtxn 10 Protein (Amino Acid, Peptide, or Protein)\tSeverity One Out of Four (Finding)", + "output": "Streptococcus pseudogalactiae (Streptococcus)" + }, + { + "input": "Definition: something described as a synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity. Talampanel noncompetitively binds to the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C38139\" active clinical trials using this agent.\nConcepts: Peritoneal Lymph Node (Lymph Node by Anatomic Site)\tfrontal male pattern baldness (Hair)\tCzechoslovakian Vlcak (Mammal)\tTesticular Cancer cTX TNM Finding v8 (Finding)\t(R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine (Central Nervous System Stimulants)", + "output": "(R)-(-)-1-(4-Aminophenyl)-3-acetyl-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzodiazepine (Central Nervous System Stimulants)" + }, + { + "input": "Definition: something described as systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.\nConcepts: Wnt-FZD-LRP5/6 trimeric complex location (Cell Component)\tadult-onset; Still (Adult-Onset Still Disease)\tJTCFAG (ECG Measurement)\tShared Anti-Idiotype AB-S005 (Monoclonal Antibodies)\tTEAR (Eye fluid)", + "output": "adult-onset; Still (Adult-Onset Still Disease)" + }, + { + "input": "Definition: Therapeutic procedure described as the use of custom fitted oral devices to treat snoring, obstructive sleep apnea or nocturnal grinding of teeth.\nConcepts: RNA RIBOSOMAL 05S (Nucleic Acid, Nucleoside, or Nucleotide)\tKnives, Surgical, Tumor, Microsurgery (scalpel)\tHave to Use Written Lists More Often than Usual to Not Forget Things (Clinical or Research Assessment Question)\thigh affinity IgA receptor activity (Molecular Function)\toral appliances (Therapeutic procedure)", + "output": "oral appliances (Therapeutic procedure)" + }, + { + "input": "Definition: Fish described as a wild-type zebrafish line, the stock of which was obtained from an area east of Calcutta in a district called Nadia.\nConcepts: Am Rested (Intellectual Product)\tComputer-Aided Design/Manufacturing Systems, Orthopedic (Computer-Aided Design/Manufacturing Systems)\tNA (Zebrafish)\tMalate-aspartate shuttle (mitochondrial transmembrane transport)\tMaize streak virus (Virus)", + "output": "NA (Zebrafish)" + }, + { + "input": "Definition: something described as a gene mutation observed with high frequency in a group that is or was geographically or culturally isolated, in which one or more of the ancestors was a carrier of the mutant gene. This phenomenon is often called a founder effect.\nConcepts: head of pancreas (Subdivision of pancreas)\tInadequate cobalt intake (Finding)\tImaging Information (Qualitative Concept)\tFounder Mutation (Cell or Molecular Dysfunction)\tnegative regulation of nucleotide degradation (regulation of nucleotide catabolic process)", + "output": "Founder Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the hydrolysis of (1->2)-alpha-D- and (1->6)-alpha-D- linkages in mannan, releasing D-mannose.\nConcepts: How satisfied or dissatisfied are you with the ability of the medication to prevent or treat your condition (Intellectual Product)\tNewborn Hearing Screening Devices (Auditory Function Screening Devices)\tTrichoadenoma of Nikolowski (Epithelial neoplasm of skin)\tIVD Test Reagent/Kits, Hematology, Fibrinolysis, Plasmin Inhibitor (IVD Test Reagent/Kits, Hematology, Fibrinolysis)\t1,2-1,6-alpha-D-mannan D-mannohydrolase activity (Molecular Function)", + "output": "1,2-1,6-alpha-D-mannan D-mannohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Tumor Suppressor Proteins described as a protein that plays a role in the inhibition of cyclin-dependent kinases.\nConcepts: CDKI Proteins (Tumor Suppressor Proteins)\tanchored component of synaptic membrane (intrinsic component of synaptic membrane)\ttracheal lumen formation (regulation of tube architecture, open tracheal system)\t6: 80001174-79967683 (Spatial Concept)\tNPI1E06 (Intellectual Product)", + "output": "CDKI Proteins (Tumor Suppressor Proteins)" + }, + { + "input": "Definition: Disease Stage Qualifier described as a mediastinal malignant germ cell tumor stage defined according to the Pediatric Study Group classification criteria.\nConcepts: Gas for Dispersion for Infusion Dosage Form (Biomedical or Dental Material)\tBIOTECHNOL (Technology)\tMediastinal Malignant Germ Cell Tumor Stage (Classification)\tActivating NTRK Point Mutation (Cell or Molecular Dysfunction)\tFollicular infundibulum tumour (Neoplasm of skin with adnexal differentiation)", + "output": "Mediastinal Malignant Germ Cell Tumor Stage (Classification)" + }, + { + "input": "Definition: something described as the cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle.\nConcepts: Parasuicide (Mental or Behavioral Dysfunction)\tS phase of mitotic cell cycle (Cell Function)\tUnplanned pregnancy counseling (Family planning counseling)\tNaIO4 compound (Indicator, Reagent, or Diagnostic Aid)\tBone-conduction hearing aid (Hearing Aids)", + "output": "S phase of mitotic cell cycle (Cell Function)" + }, + { + "input": "Definition: Compound dental impression material described as compound dental impression materials with thermoplastic properties, whose main component is wax. They are designed to make an accurate negative reproduction of a given area of the oral cavity. These compound dental impression materials consist of a base wax (e.g., hydrocarbon or ester types), additional waxes acting as modifiers, colorants, and excipients. Compound wax dental impression materials are supplied in sheets, wafers, and/or sticks. These compound dental impression materials should not shrink or distort as they cool. They are used in dental offices for checking and maintaining accurate occlusal records, for construction of nonmetallic denture bases and for laboratory work.\nConcepts: Bone Cancer Pathologic Primary Tumor TNM Finding v8 (Bone Cancer Pathologic TNM Finding v8)\tegocentrism (Mental Process)\tmetaplastic cell transformation (Pathologic Function)\tWax Compound Dental Impression Materials (Compound dental impression material)\tABC13 (Gene or Genome)", + "output": "Wax Compound Dental Impression Materials (Compound dental impression material)" + }, + { + "input": "Definition: Sphygmomanometers, Electronic, Automatic described as automatic electronic sphygmomanometers that measure the change in blood volume taking place in a single finger. Most of these instruments use a cuff wrapped around a finger; the cuff detects minute arterial volume changes in conjunction with an inflatable bladder which exerts pressure (counterpressure) just sufficient to equal the arterial pressure.\nConcepts: Microcephalus, glomerulonephritis, marfanoid habitus syndrome (Mental Retardation)\tAnti-Tac (Murine-human monoclonal immunoglobulin G antibody)\tCollagen Type IV Alpha 6 Chain wt Allele (Gene or Genome)\tHave Problem with Repeated Injections (Intellectual Product)\tSphygmomanometers, Electronic, Automatic, Plethysmographic (Medical Device)", + "output": "Sphygmomanometers, Electronic, Automatic, Plethysmographic (Medical Device)" + }, + { + "input": "Definition: something described as human HRAS wild-type allele is located in the vicinity of 11p15.5 and is approximately 3 kb in length. This allele, which encodes GTPase HRas protein, is involved in cellular mitogenesis. Mutations of HRAS are implicated in Costello syndrome, bladder cancer and oral squamous cell carcinoma.\nConcepts: C-H-RAS (HRAS gene)\tMyo-Inositol 1,4,5-Trisphosphate (Biologically Active Substance)\tModerate Reduction in Energy or Pep that Limits a Few Activities (Clinical or Research Assessment Answer)\tMyocardium of papillary muscle of right ventricle (Myocardium of region of ventricle)\tConcomitant Medication Class (Qualitative Concept)", + "output": "C-H-RAS (HRAS gene)" + }, + { + "input": "Definition: something described as DNA-binding protein inhibitor ID-2 (134 aa, ~15 kDa) is encoded by the human ID2 gene. This protein is involved in the modulation of DNA binding by transcription factors.\nConcepts: Midline supraumbilical raphe (External features)\tFAC043-I Have a Lack of Energy (Intellectual Product)\tID2H protein, human (Biologically Active Substance)\tAlseroxylon - chemical (Biologically Active Substance)\tCardiac conduction disorder (Heart)", + "output": "ID2H protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a class of proteins that bind DNA but require the presence of specific string of bases.\nConcepts: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine (Molecular Function)\tReagents, Hematology, Stain (Indicator, Reagent, or Diagnostic Aid)\tglycerol-3-phosphate transmembrane transport (organophosphate ester transport)\tMixed oligoastrocytoma (Neoplastic Process)\tSequence-Specific DNA Binding Protein (Biologically Active Substance)", + "output": "Sequence-Specific DNA Binding Protein (Biologically Active Substance)" + }, + { + "input": "Definition: pulmonary fibrosis/granuloma described as chronic inflammation and progressive fibrosis of the pulmonary alveolar walls with steady progressive dyspnea; finally, resulting in death from lack of oxygen or right heart failure.\nConcepts: Cryptogenic Fibrosing Alveolitis (Alveolitis)\tBovine Albumin (Serum Albumin)\tNSAA - Hop Right Leg (NSAA Clinical Classification Question)\tProduct containing adenosine A2 receptor agonist (Purinergic P1 Receptor Agonists)\tpositive regulation of stomach fundus smooth muscle contraction (positive regulation of gastro-intestinal system smooth muscle contraction)", + "output": "Cryptogenic Fibrosing Alveolitis (Alveolitis)" + }, + { + "input": "Definition: Leukoplakia, Oral described as leukoplakia of the oral mucosa that is clinically characterized by the presence of erythematous or red and white patches.\nConcepts: PLAP-1 (Gene or Genome)\tintra abdominal lymph nodes (Lymph Node by Anatomic Site)\terythroleukoplakia (Disease or Syndrome)\tStage IIIA Eyelid Carcinoma (stage III eyelid carcinoma)\tCells, Sertoli (Testis)", + "output": "erythroleukoplakia (Disease or Syndrome)" + }, + { + "input": "Definition: something described as prostaglandin E synthase (152 aa, ~17 kDa) is encoded by the human PTGES gene. This protein may play a role in TP53 induced apoptosis.\nConcepts: X-Linked West Syndrome (Dystonia Disorders)\tSIQ01-Killing Myself Would Solve Problem (SIQ Questionnaire Question)\tGrade 1 Teratoma (Neoplastic Process)\tProstaglandin E Synthase, human (Enzyme)\tHypothalamohypophyseal Portal System (Portal Venous System)", + "output": "Prostaglandin E Synthase, human (Enzyme)" + }, + { + "input": "Definition: Domain described as an interventions domain that contains the agents administered to the subject as part of a procedure or assessment, as opposed to drugs, medications and therapies administered with therapeutic intent.\nConcepts: Procedure Agents Domain (Intellectual Product)\tpleural mesothelioma (Neoplasia of the pleura)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(8;14) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)\tnegative regulation of glucocorticoid secretion (negative regulation of corticosteroid hormone secretion)\tchldbrth prep ndvdl ea.15min (Therapeutic or Preventive Procedure)", + "output": "Procedure Agents Domain (Intellectual Product)" + }, + { + "input": "Definition: nitrogenous heterocyclic compound described as a series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.\nConcepts: lens fiber cell apoptotic process (Cell Function)\tBVAS - Birmingham Vasculitis Activity Score (Intellectual Product)\tamygdaloid islands (Body Part, Organ, or Organ Component)\tpurine (Heterocyclic Compounds, 2-Ring)\tEpidermal Growth Factor Receptor Gene c.2240 2254del15 (EGFR Exon 19 Deletion Mutation)", + "output": "purine (Heterocyclic Compounds, 2-Ring)" + }, + { + "input": "Definition: Finding described as lung cancer with separate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor.\nConcepts: Claudin-7 Staining Method (Immunohistochemistry)\tSimaba (Plant)\tAdult sialic acid storage dis (Sialic storage disease)\tLung Cancer pM1a TNM Finding v8 (Lung Cancer pM1 TNM Finding v8)\tH (Temporal Concept)", + "output": "Lung Cancer pM1a TNM Finding v8 (Lung Cancer pM1 TNM Finding v8)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the autonomic nervous system over time, from its formation to the mature structure. The autonomic nervous system is composed of neurons that are not under conscious control, and is comprised of two antagonistic components, the sympathetic and parasympathetic nervous systems. The autonomic nervous system regulates key functions including the activity of the cardiac (heart) muscle, smooth muscles (e.g. of the gut), and glands.\nConcepts: Action Potential (Membrane Potentials)\tCommon Acute Lymphoblastic Leukemia Antigen (Enzyme)\tautonomic nervous system development (system development -- biological)\tregulation of DNA stability (regulation of biological quality)\tPimelic Acids (Dicarboxylic Acids)", + "output": "autonomic nervous system development (system development -- biological)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire - With regard to your physical health, during the past week how much of the time have you: Felt able to be as physically active as needed?\nConcepts: Adult Hodgkin Lymphoma by Ann Arbor Stage (Hodgkin Lymphoma by Ann Arbor Stage)\tQLES1-Be as Physically Active as Needed (Q-LES-Q Questionnaire Question)\tresponse to erythromycin (response to organic cyclic compound)\tFlat sella turcica (Deformed sella turcica)\tPSA Level Between Zero and Two (Laboratory or Test Result)", + "output": "QLES1-Be as Physically Active as Needed (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: something described as any series of molecular signals generated as a consequence of binding to toll-like receptor 12.\nConcepts: Procedure Kit/Trays, Implant Delivery, Hyoid Bone/Tongue Suspension (Procedure Kit/Trays, Implant Delivery)\tFC (Dietary Practices)\tposterior insular cortex (Insula of Reil)\tConductometry (Laboratory Procedure)\tTLR12 signaling pathway (Toll-Like Receptor Signaling Pathway)", + "output": "TLR12 signaling pathway (Toll-Like Receptor Signaling Pathway)" + }, + { + "input": "Definition: A [Preparations] described as a drug combination that contains THEOPHYLLINE and ethylenediamine. It is more soluble in water than theophylline but has similar pharmacologic actions. It's most common use is in bronchial asthma, but it has been investigated for several other applications.\nConcepts: Tester/Chargers, Battery (Manufactured Object)\tplasmid encoding antiangiogenic metargidin peptide (Angiogenesis Inhibitors)\tCSS08-Interrupted Attempt, Describe (Intellectual Product)\tSeptal division of left branch of atrioventricular bundle (Body Part, Organ, or Organ Component)\tTheophyline Ethylenediamine (Organic Chemical)", + "output": "Theophyline Ethylenediamine (Organic Chemical)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify genetic variants associated with Bardet-Biedl syndrome, a multisystem disorder characterized by vision loss, obesity, and additional signs and symptoms affecting other parts of the body. Genetic variants at multiple loci have been associated with Bardet-Biedl syndrome. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple Bardet-Biedl syndrome-associated loci simultaneously.\nConcepts: Bardet-Biedl Syndrome Gene Panel Reagents (Medical Device)\tInsurance, Vision Care (Health Insurance)\tgenetic strain (Biologic Function)\tSUBCONTRACTOR CONTACT (contact person)\tSecretory-Stage Ameloblast (Ameloblasts)", + "output": "Bardet-Biedl Syndrome Gene Panel Reagents (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as a terminology subset for the NCPDP that contains concepts of various measurements of vital signs, particularly those pertaining to information about a patient that would be shared between clinician and pharmacy in order to determine proper pharmaceutical care.\nConcepts: Fractional Excretion of Calcium (Laboratory Procedure)\tBahamian race (Population Group)\tHC (Adrenal Cortex Hormones)\tNCPDP Measurement Unit Code Terminology (Intellectual Product)\tSmall stomach worm (Trichostrongylus)", + "output": "NCPDP Measurement Unit Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: Immunity, Innate described as a defense response against viruses mediated through an innate immune response. An innate immune response is mediated by germline encoded components that directly recognize components of potential pathogens.\nConcepts: DNA, D(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) (Antineoplastic Agents)\tSensory Gating (Nervous System Physiological Phenomena)\tNeurocognitive Assessment (Assessment: Cognition)\tHallopeau Siemens Disease (Vesiculobullous Diseases)\tantiviral innate immune response (Organism Attribute)", + "output": "antiviral innate immune response (Organism Attribute)" + }, + { + "input": "Definition: Signaling Pathway Gene described as this gene may play a role in signal transduction.\nConcepts: RCS (Gene or Genome)\tcountries (Geographic Area)\tBiliary Atresia, Intrahepatic (Abnormality of the intrahepatic bile duct)\tGranules for Vaginal Solution Dosage Form (Granule for Solution Dosage Form)\tHER2 (Protein or Enzyme Type Measurement)", + "output": "RCS (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as surgical scissors designed to cut and dissect tissues in the uterus and surrounding tissues. These scissors are typically handheld manual instruments with two metallic (e.g., stainless steel) wide, straight, or curved blades with rounded blunt tips that slide past each other (i.e., shearing action). The blades are attached to handles with the proximal end conformed as a ring to facilitate holding and operating with the fingers; both parts are joined by a swivel pin in the center. Uterine surgery scissors are used in procedures involving the uterus and surrounding tissues; dedicated scissors for cutting the parametrium in radical vaginal hysterectomy are also available.\nConcepts: Sheets, Operating Room Table (Bed sheets)\tSquamoid Ductal Eccrine Carcinoma (Neoplastic Process)\tChest/Abdominal/Pelvic CT without Contrast (Diagnostic Procedure)\tScissors, Surgical, Uterine (Medical Device)\tSchistosoma japonicum (Eukaryote)", + "output": "Scissors, Surgical, Uterine (Medical Device)" + }, + { + "input": "Definition: Parapsoriasis described as a variant of parapsoriasis in which the plaques are small.\nConcepts: Gastrointestinal hemorrhage (Hemorrhage of digestive system)\tDengue Virus Antibody Measurement (Laboratory Procedure)\tSmall Plaque Parapsoriasis (Parapsoriasis)\tEmory Treatment Resistance Interview for PTSD Clinical Classification Test Name (Intellectual Product)\tpreterm infant animal (Animal)", + "output": "Small Plaque Parapsoriasis (Parapsoriasis)" + }, + { + "input": "Definition: Health Care Activity described as any elsewhere undefined new client home-visit with nursing diagnosis, narrative required. Use this code to describe advanced nursing care without physician oversight. The client may or may not have a medical diagnosis. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: ethanol oxidation (Ethanol Metabolism)\tDNA HELICASE, RECQ-LIKE, TYPE 4 (Gene or Genome)\tCongenital dislocation, NOS (Congenital anomaly of bone and joint)\tQLES153A (Q-LES-Q Questionnaire Question)\tUndefined nurse new client home-visit with nursing diagnosis narrative required (New client home-visit with nursing diagnosis)", + "output": "Undefined nurse new client home-visit with nursing diagnosis narrative required (New client home-visit with nursing diagnosis)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a spray contained in a device with valves that permits the dispensing of a specified quantity of active and/or inert ingredient(s) upon activation.\nConcepts: Spray, metered (Spray Dosage Form)\tSesquiterpene Lactone (Biologically Active Substance)\t2-Aminobutanoic Acid (Amino Acid, Peptide, or Protein)\tcyanelle intermembrane space (plastid intermembrane space)\tkarenitecin (Organic Chemical)", + "output": "Spray, metered (Spray Dosage Form)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Colorectal Version 4 (FACT-C Version 4) Additional Concerns: Do you have an ostomy appliance?\nConcepts: SPINOCEREBELLAR ATAXIA, X-LINKED 4 (Ataxia, Spinocerebellar)\tpositive regulation of turning behavior involved in mating (positive regulation of male mating behavior)\tCreative thought (Personality Traits)\tDoxorubicin-Fluorouracil-Semustine (Therapeutic or Preventive Procedure)\tFAC008-Do You Have an Ostomy Appliance (Intellectual Product)", + "output": "FAC008-Do You Have an Ostomy Appliance (Intellectual Product)" + }, + { + "input": "Definition: something described as an intermediate in the pathway of coenzyme A formation in mammalian liver and some microorganisms.\nConcepts: Comp prolonged new 180 min (Health Care Activity)\tRAB6 interacting protein 2 (Signaling Pathway Gene)\tAssociated Persons Medical History Domain (Associated Persons Domain)\tCTImagingAcquisitionProtocolElement.tableSpeed (Quantitative Concept)\tPantetheine (Sulfhydryl Compounds)", + "output": "Pantetheine (Sulfhydryl Compounds)" + }, + { + "input": "Definition: GABAergic neuron differentiation described as the process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex.\nConcepts: su./hol care narr req'd (Therapeutic or Preventive Procedure)\tcerebellar Golgi cell differentiation (cell differentiation in hindbrain)\tHCGF (Biologically Active Substance)\tDEND (developmental delay, epilepsy, neonatal diabetes) syndrome (Epilepsy)\tESRSA1-Dyskinesia: Hips/Lower Limbs/Feet (ESRS-A Clinical Classification Question)", + "output": "cerebellar Golgi cell differentiation (cell differentiation in hindbrain)" + }, + { + "input": "Definition: Ophthalmological equipment described as an optokinetic drum is a drum-like device covered with alternating white and dark stripes or pictures that can be rotated on its handle. The device is intended to elicit and evaluate nystagmus (involuntary rapid movement of the eyeball) in patients.\nConcepts: Swine influenza (Non-human disorder)\tAntitachycardia Pacing (Therapeutic or Preventive Procedure)\tOptokinetic drum (Ophthalmological equipment)\tRadiation, Beta (Ionizing radiation)\tmagnocellular nucleus of the posterior commissure (Body Part, Organ, or Organ Component)", + "output": "Optokinetic drum (Ophthalmological equipment)" + }, + { + "input": "Definition: something described as hypodermic needles designed to provide needlestick protection. These needles include some manually and/or automatically activated mechanism intended to shield, blunt, or recess the needle during or after use or, by some other means, to reduce the possibility of contact between the healthcare provider and the sharp needle. Protective hypodermic needles may be used with hypodermic syringes designed for specific injection sites (e.g., dental).\nConcepts: piRNA dual-strand cluster binding (Genetic Function)\tGlucose Monitoring Software (Intellectual Product)\tLower lobe of left lung (Body Part, Organ, or Organ Component)\tInfant ALL (Childhood Acute Lymphoblastic Leukemia)\tHypodermic Needles, Protective (Medical Device)", + "output": "Hypodermic Needles, Protective (Medical Device)" + }, + { + "input": "Definition: Vesicular Neurotransmitter Transport Proteins described as a family of vesicular neurotransmitter transporter proteins that were originally characterized as sodium dependent inorganic phosphate cotransporters. Vesicular glutamate transport proteins sequester the excitatory neurotransmitter GLUTAMATE from the CYTOPLASM into SECRETORY VESICLES in exchange for lumenal PROTONS.\nConcepts: Nabumetonum (Nonsteroidal Anti-inflammatory Drug [EPC])\tDual-time Scan (Diagnostic Procedure)\tAngioimmunoblastic T-Cell Lymphoma Stage III (Angioimmunoblastic T-Cell Lymphoma by Ann Arbor Stage)\tVesicular Glutamate Transporter (Biologically Active Substance)\tShoes, Orthopedic, Rotation Correction (Shoes, Orthopedic)", + "output": "Vesicular Glutamate Transporter (Biologically Active Substance)" + }, + { + "input": "Definition: Verbal Rating Scale described as a type of verbal rating scale composed of 4 items.\nConcepts: ENSAT Stage II Adrenal Cortex Carcinoma (Adrenal Cortex Carcinoma by ENSAT Stage)\tVRS 4-Point (Intellectual Product)\t3q25.1-q26.1 (Chromosome band)\tBladder Spasm, CTCAE 5 (Renal and Urinary Disorders, CTCAE)\tDecreased female libido (Female sexual dysfunction)", + "output": "VRS 4-Point (Intellectual Product)" + }, + { + "input": "Definition: Property or Attribute described as a condition superior to an earlier condition.\nConcepts: negative regulation of neuromuscular junction organization (Cell Function)\tImprovement (Conceptual Entity)\tI have accepted my illness (Intellectual Product)\tNational Institute on Deafness and Other Communication Disorders (Health Care Related Organization)\tUlnar Nerve Compression, Cubital Tunnel (Mononeuropathies)", + "output": "Improvement (Conceptual Entity)" + }, + { + "input": "Definition: something described as a collection of agendas, presentation materials and other documentation generated for attendees during an internal or external Trial Management category-related meeting. These are agreements or significant discussions, including but not limited to meeting minutes, or Q&A, attendance sheets, and any pre-meeting material.\nConcepts: Trial Mgmt Mtng (Study Material)\tFACT-LEU Version 4 - I Bleed Easily (FACT-LEU Version 4 Questionnaire Question)\tOlfactory Sensory Cells (olfactory nerve system)\tHeel bone (Organ component of calcaneus)\tMeditation Therapy (Mind-Body Medicine)", + "output": "Trial Mgmt Mtng (Study Material)" + }, + { + "input": "Definition: Disorder of body cavity described as a non-neoplastic or neoplastic disorder affecting the ureter.\nConcepts: regulation of acute inflammatory response to antigenic stimulus (Pathologic Function)\tI have been so anxious about my PSA test that I have thought about delaying it (Clinical or Research Assessment Question)\tUreteric Disorder (Kidneys and Urinary System)\tIPA03-No Vigorous Activity Leisure Time (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tg/ml/(ug/d) (Quantitative Concept)", + "output": "Ureteric Disorder (Kidneys and Urinary System)" + }, + { + "input": "Definition: Topical Dosage Form described as a topical formulation containing the antimetabolite 5-fluorouracil (5-FU), with antineoplastic activity. Upon topical administration, 5-FU is converted into the active metabolite 5-fluoroxyuridine monophosphate (F-UMP), which competes with uracil during RNA synthesis and inhibits RNA processing. Conversion of 5-FU into another active metabolite, 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate (F-dUMP), inhibits thymidylate synthase; this results in the depletion of thymidine triphosphate (TTP), one of the four nucleotide triphosphates used in DNA synthesis, and thus inhibits DNA synthesis. Altogether, this prevents the proliferation of tumor cells locally. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C125194\" active clinical trials using this agent.\nConcepts: How Often Urination Problem (Clinical or Research Assessment Question)\tExposure Sequence Number (Intellectual Product)\tFluorouracil Topical (fluorouracil)\tApoptosis-Inducing Receptor AIR (Tumor Necrosis Factor Receptor)\tTargetAnatomicSiteDirectionalityCode (Intellectual Product)", + "output": "Fluorouracil Topical (fluorouracil)" + }, + { + "input": "Definition: methyltransferase activity described as catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate.\nConcepts: Alkaloid Opiates (Organic Chemical)\t5-methyltetrahydrofolate-dependent methyltransferase activity (Molecular Function)\tCCL2/CCR2 signaling pathway (chemokine (C-C motif) ligand 2 signaling pathway)\tPROTPATN (Protein or Enzyme Type Measurement)\tInfection, Secondary (Disease or Syndrome)", + "output": "5-methyltetrahydrofolate-dependent methyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as a contraceptive tubal occlusion device (TOD) and introducer is a device designed to close a fallopian tube with a mechanical structure, e.g., a band or clip on the outside of the fallopian tube or a plug or valve on the inside. The devices are used to prevent pregnancy.\nConcepts: CNK1 (CNKSR1 gene)\tDepolymerization (Macromolecular alteration)\tINSERT, TUBAL OCCLUSION (Medical Device)\tIVD Test Reagent/Kits, Immunoassay, Lipoprotein-Associated Enzyme Phospholipase A2 (Medical Device)\tPheochromocyte (Paraganglia structure)", + "output": "INSERT, TUBAL OCCLUSION (Medical Device)" + }, + { + "input": "Definition: protein localization to cilium described as a process in which a protein is transported to, or maintained in, a location within a ciliary inversin compartment.\nConcepts: protein localization to ciliary inversin compartment (protein localization to cilium)\tbenign tumor of Bartholin's gland (Lesion of female perineum)\tOCI (Intellectual Product)\tPolycomb Repressive Complex Protein (Chromosomal Proteins, Non-Histone)\tNeurofilament-H (Neurofilaments)", + "output": "protein localization to ciliary inversin compartment (protein localization to cilium)" + }, + { + "input": "Definition: Idea or Concept described as a well-substantiated explanation of some aspect of the natural world.\nConcepts: bones structures (Body Part, Organ, or Organ Component)\tK (Elements, Ions and Simple Compounds)\tInositol-Trisphosphate 3-Kinase C (Enzyme)\tTheory (Thesaurus of Psychological Index Terms)\t16: 88280579-88290263 (Spatial Concept)", + "output": "Theory (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Finding described as problem associated with information unable to be read or deciphered.\nConcepts: Progesterone Receptor Positive by Immunohistochemistry 91-100 Percent (Progesterone Receptor Positive by Immunohistochemistry)\tIntraoperative ear injury (Intraoperative injury)\tIllegible Information (Device Markings/Labeling Problem)\tIpomoea (Ipomoeeae)\tMANOMETER, WATER (Medical Device)", + "output": "Illegible Information (Device Markings/Labeling Problem)" + }, + { + "input": "Definition: something described as a question about an individual's assessment of how often they have been bothered by emotional problems in the past seven days.\nConcepts: Moderately Satisfied (Clinical or Research Assessment Answer)\tIn the past 7 days, how often have you been bothered by emotional problems such as feeling anxious, depressed or irritable (Intellectual Product)\tpyramidal neuron development (forebrain neuron development)\tmyomegalin protein, human (Binding Proteins)\tSuture of palate (Mouth repair)", + "output": "In the past 7 days, how often have you been bothered by emotional problems such as feeling anxious, depressed or irritable (Intellectual Product)" + }, + { + "input": "Definition: something described as a unique symbol that establishes identity of the place.\nConcepts: Stratified Cuboidal Epithelium (Tissue)\tregulation of chromosome separation (Cell Function)\tACER3 wt Allele (ACER3 gene)\tHistory, Ancient (Temporal Concept)\tPlace Identifier (Identifier)", + "output": "Place Identifier (Identifier)" + }, + { + "input": "Definition: Gestational Trophoblastic Neoplasms described as this term is used when a complete mole or very rarely a partial mole invades the myometrium. Microscopically, villi of hydatidiform mole are present within the myometrium or the myometrial vessels. Patients have persistent or rising hCG levels. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6985\" active clinical trials using this agent.\nConcepts: Invasive Hydatidiform Moles (Gestational Trophoblastic Neoplasms)\tSOFTWARE UPDATE (Maintenance)\t11: 47247535-47308158 (Spatial Concept)\tcycloCMP hydrochloride (Pharmacologic Substance)\tPerceptions, Self (Mental Process)", + "output": "Invasive Hydatidiform Moles (Gestational Trophoblastic Neoplasms)" + }, + { + "input": "Definition: something described as a temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual. []\nConcepts: management medication (Therapeutic procedure)\tD-methionine transmembrane transporter activity (methionine transmembrane transporter activity)\tProtein Expression (Gene Expression Process)\tdetection of low humidity stimulus involved in sensory perception (Organ or Tissue Function)\tAbnormal temper tantrums (Mental or Behavioral Dysfunction)", + "output": "Abnormal temper tantrums (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a group of blood proteins that contains antibodies\nConcepts: ii phase study (Clinical Trials)\tEnteroscope (Medical Device)\tgamma-globulin (Vaccine, immunoglobulin, AND/OR antiserum)\tPaclitaxel (Taxane derivative)\tPerformed Activity Negation Indicator (Negation Indicator)", + "output": "gamma-globulin (Vaccine, immunoglobulin, AND/OR antiserum)" + }, + { + "input": "Definition: something described as a question about an individual's distress from feeling bloated.\nConcepts: Grade 2 Sinus pain (Sinus Pain, CTCAE 3.0)\tTumor Susceptibility Gene 101 wt Allele (TSG101 gene)\tPhenylpyruvic Acids (Acids, Carbocyclic)\tresponse to abscisic acid (response to alcohol)\tFeeling bloated (Intellectual Product)", + "output": "Feeling bloated (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as any process that activates, maintains or increases the frequency, rate or extent of sporangiospore formation, a process in which sporangiospores, a type of asexual spore found in fungi, are formed. Sporangiospores are formed within sac-like structure, the sporangium, following the division of the cytoplasm.\nConcepts: COXEN Score 17 (COXEN Sensitivity Scale)\tpositive regulation of sporangiospore formation (regulation of sporangiospore formation)\tCD56+ (Laboratory or Test Result)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, OTC (Medical Device)\tFluid and/or electrolyte management initial 60 minutes (Common nursing interventions)", + "output": "positive regulation of sporangiospore formation (regulation of sporangiospore formation)" + }, + { + "input": "Definition: Benign neoplasm of skin described as a benign adenoma neoplasm with sebaceous differentiation.\nConcepts: nicotinamide riboside transmembrane transporter activity (nucleoside transmembrane transporter activity)\tPhenylbutyrates (Butyrates)\tSebaceous gland adenoma (Adnexal AND/OR skin appendage neoplasm)\tcow (Ambiguous concept)\tChaplaincy Services, Hospital (Hospital Departments)", + "output": "Sebaceous gland adenoma (Adnexal AND/OR skin appendage neoplasm)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as using naturopathic techniques to manipulate the flow of cerebrospinal fluid to affect a client's craniosacral rhythm. Service is billed per manipulation.\nConcepts: 68Ga-NODAGA-E(c[RGDyK])2 (Indicator, Reagent, or Diagnostic Aid)\tCraniosacral osseous manipulation each manipulation (Therapeutic or Preventive Procedure)\tCongenital Neurogenic Bladder (Neurogenic Urinary Bladder)\tIVD Test Reagent/Kits, Serology, Bacteria, Listeria monocytogenes, IgM Antibody (Medical Device)\tEnah/Vasp-like (Gene or Genome)", + "output": "Craniosacral osseous manipulation each manipulation (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Psychoanalytic Theory described as self-love in which all sources of pleasure are unrealistically believed to emanate from within oneself, resulting in a false sense of omnipotence, and in which the libido is no longer attached to external love objects, but is redirected to one's self.\nConcepts: SF-36 v2.0 Acute - Question 5a (SF36 v2 0 Acute Questionnaire Question)\tFalse Mayweed (Asteraceae)\tnarcissism (Psychoanalytic Theory)\tDetectors, Gas Chromatography (Chromatography Systems)\tchick embryo (Embryo, Nonmammalian)", + "output": "narcissism (Psychoanalytic Theory)" + }, + { + "input": "Definition: Discipline of Nursing described as clinical nursing applies the skills and processes of nursing to patients in an acute care environment.\nConcepts: Bretylium Compounds (Benzylammonium Compounds)\tchildhood Hodgkin's disease, relapsed (Recurrent Hodgkin Lymphoma)\tNursing Sciences, Clinical (Health Care Activity)\tMastocytosis (stage, chronic myeloproliferative neoplasms)\tLiver Kidney Microsomal Type 1 IgM Antibody Measurement (Laboratory Procedure)", + "output": "Nursing Sciences, Clinical (Health Care Activity)" + }, + { + "input": "Definition: Regimen Used to Treat Gestational Trophoblastic Tumor described as a regimen consisting of dactionmycin, cisplatin and etoposide, used for the treatment of poor-prognosis metastatic gestational trophoblastic tumors.\nConcepts: boronic acid (Boron Compounds)\tAPE/Gestational Trophoblastic Tumor Regimen (Therapeutic or Preventive Procedure)\tUnknown (Unknown)\tMonitors, Compressed Air/Gas, Dew-Point (Medical Device)\tmyosin heavy chain binding (Molecular Function)", + "output": "APE/Gestational Trophoblastic Tumor Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Chimeric Antigen Receptor T-cells described as a preparation of genetically modified allogeneic T-cells transduced with a replication-incompetent, self-inactivating lentiviral vector expressing a hinge-optimized, chimeric antigen receptor (CAR), comprised of a CD28 co-stimulatory signaling domain fused to CD3 zeta, the single-chain variable fragment of CD123 antigen (interleukin-3 receptor alpha chain or IL3RA), and a truncated form of the human epidermal growth factor receptor (EGFRt), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, allogeneic CD123CAR-CD28-CD3zeta-EGFRt-expressing T-lymphocytes are directed to and induce selective toxicity in CD123-expressing tumor cells. CD123 is normally expressed on committed blood progenitor cells in the bone marrow; its overexpression is associated with increased leukemic cell proliferation and aggressiveness. Devoid of both ligand binding domains and tyrosine kinase activity, EGFRt both facilitates detection of the administered T-cells in vivo and can promote elimination of those cells following a cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) response. The costimulatory signaling domain enhances both proliferation of T-cells and antitumor activity. Hinge optimization prevents recognition of the CAR by Fc receptors (FcRs).\nConcepts: symphysis pubis (Joint structure of trunk)\tAllogeneic CD123R(EQ)28zeta/EGFRt+ T Cells (Chimeric Antigen Receptor T-cells)\tAnterolateral Myocardial Infarction by EKG Finding (Electrocardiogram: myocardial infarction)\thepatitis g (Disease or Syndrome)\tPseudohermaphroditism syndrome (Gender disorders)", + "output": "Allogeneic CD123R(EQ)28zeta/EGFRt+ T Cells (Chimeric Antigen Receptor T-cells)" + }, + { + "input": "Definition: something described as a modified electronic platform that uses an algorithmic approach that integrates treatment summaries, self-assessments, discussion guides, and survivorship care plans to provide personalized care in cancer survivorship clinics.\nConcepts: Lack of skin coloring on chest (Finding)\tAnaerobic Chambers (Chamber)\tHN-STAR (Intellectual Product)\tLY-3295668 (Antineoplastic Agents)\tup regulation of protein positioning (positive regulation of biological process)", + "output": "HN-STAR (Intellectual Product)" + }, + { + "input": "Definition: Phenotype described as a genetic marker marked by the presence of mutations in genes that maintain genomic integrity, which leads to greatly increased rates of mutation for the rest of the genome and may induce malignant transformation.\nConcepts: nicotinamide mononucleotide phosphatase activity (Molecular Function)\tpositive regulation of histone ubiquitination (Genetic Function)\tXAF1 (Gene or Genome)\tRecurrent Metastatic Malignant Neoplasm (Secondary Neoplasm)\tHypermutator Phenotype (Phenotype)", + "output": "Hypermutator Phenotype (Phenotype)" + }, + { + "input": "Definition: Refractory Sarcoma described as ewing sarcoma that does not respond to treatment.\nConcepts: Thoraco-abdominal enteric duplication (Congenital Abnormality)\tMelphalan-Cyclophosphamide-Prednisone (Therapeutic or Preventive Procedure)\tFACT-BMT Version 4 - I Have Tremors (FACT-BMT Version 4 Questionnaire Question)\tnegative regulation of neuronal cell death (Negative Regulation of Cell Death)\tRefractory Ewing Sarcoma (Ewings sarcoma)", + "output": "Refractory Ewing Sarcoma (Ewings sarcoma)" + }, + { + "input": "Definition: something described as the volume enclosed by the membrane of a COPI-coated endocytic vesicle.\nConcepts: vascular transport (Biological Transport)\tCobalt 60 (Cobalt Radioisotopes)\tfemale meiosis chromosome segregation (Cell Function)\tCOPI-coated vesicle lumen (cytoplasmic vesicle lumen)\tPrimary Cerebral Non-Hodgkin's Lymphoma (Neoplastic Process)", + "output": "COPI-coated vesicle lumen (cytoplasmic vesicle lumen)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient believe that unwelcome guests are living in his/her house?\nConcepts: ADL03-Talk About TV Content Within a Day (ADCS-ADL MCI Questionnaire Question)\tPREVOTELLA NIGRESCENS (Bacterium)\tDelayed carpal ossification (Abnormality of carpal bone ossification)\tNPI1A04 (NPI Questionnaire Question)\tBDNF signalling pathway (Molecular Function)", + "output": "NPI1A04 (NPI Questionnaire Question)" + }, + { + "input": "Definition: Zygomycota described as the only fungal genus in the Syncephalastraceae family within the Mucorales order. Sporangiospores are produced asexually through the development of cylindrical merosporangia; however, syncephalastrum also undergoes a sexual cycle that produces zygospores. It is primarily isolated from animal excrement, plant material, and soil in tropical or subtropical regions.\nConcepts: Genus Syncephalastrum (Mucorales)\tMiddle Ears (Body Space or Junction)\tDifferential Uptake Ratio (Quantitative Concept)\tGDS01-Avoid Social Gatherings (Intellectual Product)\tup regulation by symbiont of host defense-related programmed cell death (Organism Function)", + "output": "Genus Syncephalastrum (Mucorales)" + }, + { + "input": "Definition: Medical Device described as microbiology reagents intended to identify fungi of more than one genera and/or species in clinical laboratory tests. The tests can typically detect fungi of the genera Aspergillus, Blastomyces, Coccidioides, and Histoplasma.\nConcepts: IVD Test Reagent/Kits, Microbiology, Fungi/Yeast, Identification, Multifungi (Medical Device)\tExtracorporeal Shockwave Therapy (Therapeutic or Preventive Procedure)\tX-linked intellectual disability Nascimento type (Disease or Syndrome)\tNurse Stations (Hospital Units)\tABSORBER, SALIVA, PAPER (Medical Device)", + "output": "IVD Test Reagent/Kits, Microbiology, Fungi/Yeast, Identification, Multifungi (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as human LYVE1 wild-type allele is located in the vicinity of 11p15 and is approximately 11 kb in length. This allele, which encodes lymphatic vessel endothelial hyaluronic acid receptor 1 protein, plays a role in binding hyaluronan and may regulate intracellular transport of hyaluronan.\nConcepts: HAR (Gene or Genome)\tSZ (South African country)\tItem Response Theory (Theory)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Legs Hurt (Intellectual Product)\tBRACHIOSKELETOGENITAL SYNDROME (Mental Retardation)", + "output": "HAR (Gene or Genome)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"no\" to Question 52 above, was your child's activity limited by: Too young?\nConcepts: Facility Contact Backup (Human)\tpluripotent (General Qualifier)\tAir Cleaners, Particulate/Gas/Vapor (Air Cleaners - Device)\tPODCI258 (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tT Cell Receptor gamma Chain (Amino Acid, Peptide, or Protein)", + "output": "PODCI258 (PODCI Adolescent Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.\nConcepts: mcg*min/mL (Quantitative Concept)\tcyanuric acid metabolism (s-triazine compound metabolic process)\tShields, Radiotherapy Block (Medical Device)\tup regulation of wax synthesis (positive regulation of biosynthetic process)\tLeave, Plant (Plant Components, Aerial)", + "output": "cyanuric acid metabolism (s-triazine compound metabolic process)" + }, + { + "input": "Definition: Fiat anatomical line of head described as fiat anatomical line of head bounded by subnasale and gnathion.\nConcepts: inulin (I [Preparations])\tLower facial vertical line (Body Location or Region)\tRetrochiasmatic region (Hypothalamus, Middle)\tPROTHROMBIN DEFIC (Coagulation factor deficiency syndrome)\tNIPPLE, LAMBS FEEDING (Medical Device)", + "output": "Lower facial vertical line (Body Location or Region)" + }, + { + "input": "Definition: something described as the determination of the maximum amount of oxygen that can be combined chemically with hemoglobin in a volume of blood.\nConcepts: Cryptococcus neoformans gattii (Cryptococcus gattii species complex)\tOxygen Capacity Measurement (Hematologic Tests)\tpigment granule transport (pigment granule localization)\tGastrointestinal status is maintained at or improved from baseline levels (Physiologic Responses)\tSEC14-Like Protein 1 (Amino Acid, Peptide, or Protein)", + "output": "Oxygen Capacity Measurement (Hematologic Tests)" + }, + { + "input": "Definition: negative regulation of oogenesis described as any process that decreases the rate or extent of the process whose specific outcome is the progression of an oocyte over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell.\nConcepts: INPE5792 (Gene or Genome)\tA Little Helpful (Intellectual Product)\tAPOPTOSIS-ASSOCIATED SPECK-LIKE PROTEIN CONTAINING A CARD (Apoptosis Promoter Gene)\tGrade 4 Neonatal Edema, Adverse Event (Neonatal Edema, Adverse Event)\tnegative regulation of oocyte development (Cell Function)", + "output": "negative regulation of oocyte development (Cell Function)" + }, + { + "input": "Definition: Hypopituitarism described as a rare acquired pituitary hormone deficiency characterized by combination of headache, visual field defects that correlate with cyst size and pituitary dysfunction. Most frequent hormonal manifestations are hypogonadism with amenorrhea/impotence or low libido and galactorrhea.\nConcepts: tissue homeostasis (anatomical structure homeostasis)\tSpondylothoracic Dysostosis (MISCELLANEOUS MULTIPLE MALFORMATION SYNDROMES)\tFAC02314 (Intellectual Product)\tPituitary deficiency due to Rathke's cleft cysts (Disease or Syndrome)\tMRS Questionnaire Question (Clinical or Research Assessment Question)", + "output": "Pituitary deficiency due to Rathke's cleft cysts (Disease or Syndrome)" + }, + { + "input": "Definition: Procedure Kit/Trays described as prepackaged collections of the devices and supplies (i.e., either custom or standard kits) needed for procedures intended to inject directly into a large bone marrow (i.e., intraosseous). Items in these kits usually include intraosseus infusion needles, syringes, intravenous (IV) tubing and solutions, povidone-iodine swabs, and tape. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Intraosseous infusion procedure kits and trays are intended to provide fluids, blood, and medication usually when an IV line is not available or cannot be used. They are used in the field and in emergency rooms and/or other areas in healthcare facilities.\nConcepts: periodontitis chronic localized severe (Localized chronic periodontitis)\tAscending Frontal Convolution (Brain part)\tregulation of T-helper 2 cell cytokine production (regulation of T cell cytokine production)\tIntraosseous Infusion Procedure Kit/Trays (Medical Device)\tShort Limb Dwarfism-Saddle Nose-Spinal Alterations-Metaphyseal Striation Syndrome (Disease or Syndrome)", + "output": "Intraosseous Infusion Procedure Kit/Trays (Medical Device)" + }, + { + "input": "Definition: glycerophospholipid biosynthetic process described as the chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine.\nConcepts: Community Risk Control: Communicable Disease (Community risk control behavior)\tphosphatidylethanolamine synthesis (glycerophospholipid biosynthetic process)\tostomy irrigator (Medical Device)\tFM (Domain)\tNickel Protoxide (Inorganic Chemical)", + "output": "phosphatidylethanolamine synthesis (glycerophospholipid biosynthetic process)" + }, + { + "input": "Definition: Hydrocarbons described as highly carcinogenic polycyclic aromatic hydrocarbon synthesized by pyrolytic degradation of cholic acid, deoxycholic acid, or cholesterol; a procarcinogen that requires metabolic activation to exert a mutagenic effect.\nConcepts: dipeptidase activity (Molecular Function)\tMethylcholanthrene (Benz(a)Anthracenes)\tLoss of Power Identified (Device Evaluation Result)\tManual Communications (Correction of Hearing Impairment)\tviral entry via permeabilization of endosomal membrane (viral entry via permeabilization of host membrane)", + "output": "Methylcholanthrene (Benz(a)Anthracenes)" + }, + { + "input": "Definition: cellular protein-containing complex localization described as any process in which an exocyst is transported to, or maintained in, a specific location. An exocyst is a protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse.\nConcepts: Bone Marrow Unilineage Dysplasia Present (Bone Marrow Dysplasia Present)\toocyte microtubule cytoskeleton organisation (cellular process involved in reproduction in multicellular organism)\tPercutaneous (Functional Concept)\testablishment and maintenance of exocyst localization (cellular protein-containing complex localization)\tgranulomas (Physical shape)", + "output": "establishment and maintenance of exocyst localization (cellular protein-containing complex localization)" + }, + { + "input": "Definition: Anthracyclines and related substances described as a substance being studied in the treatment of lung cancer. It is a type of anthracycline analog.\nConcepts: Childhood Malignant Testicular Germ Cell Tumor (cellular diagnosis, testicular cancer)\tLIVED IN REFUGEE CAMP (Organism Attribute)\tN. meningitidis (Neisseria species)\tCellulomonas hominis (Cellulomonas)\t(+)-(7S,9S)-9-Acetyl-9-amino-7-((2-deoxy-beta-D-erythro-pentopyranosyl)oxy)- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione (Antibiotic)", + "output": "(+)-(7S,9S)-9-Acetyl-9-amino-7-((2-deoxy-beta-D-erythro-pentopyranosyl)oxy)- 6,11-dihydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione (Antibiotic)" + }, + { + "input": "Definition: cell gliding described as a process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.\nConcepts: Porphyromonas catoniae (Moore and Moore 1994) Willems and Collins 1995 emend. Hahnke et al. 2016 (Bacterium)\tPCORnet-defined Condition Algorithm (Intellectual Product)\tadventurous gliding movement (cell gliding)\tRDIORESP (Finding)\tleucine 2,3-aminomutase activity (Molecular Function)", + "output": "adventurous gliding movement (cell gliding)" + }, + { + "input": "Definition: Quantitative Concept described as general term for properties that are related to the conductance of electricity by material.\nConcepts: Citrobacter werkmanii (Citrobacter freundii complex)\telectrical property (Physical Phenomenon or Property)\tregulation of glucose detection (regulation of response to stimulus)\tdADP phosphorylation (dADP metabolic process)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Time Spend on Your Health Condition (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)", + "output": "electrical property (Physical Phenomenon or Property)" + }, + { + "input": "Definition: Malignant neoplasm of endometrium described as a highly malignant subset of neoplasms arising from the endometrial stroma. Tumors in this group infiltrate the stroma with a wide range of atypia cells and numerous mitoses. They are capable of widespread metastases (NEOPLASM METASTASIS).\nConcepts: Blasts Under 20% of Peripheral Blood White Cells (Blasts 20 Percent or Less of Peripheral Blood White Cells)\tendometrial stromal sarcomas (Neoplastic Process)\tCALIBRATOR (Manufactured Object)\tMaternal virilization in pregnancy (Finding)\tGrade 4 Skin induration (Skin Induration, CTCAE)", + "output": "endometrial stromal sarcomas (Neoplastic Process)" + }, + { + "input": "Definition: Biologically Active Substance described as myosin-11 (1972 aa, ~227 kDa) is encoded by the human MYH11 gene. This protein is involved in muscle contraction.\nConcepts: Divergent Differentiation (Tissue Differentiation)\tUNIT, BETA, RADIATION, OPHTHALMIC (Medical Device)\tSMMHC (Cytoskeletal Proteins)\tWV (Region of United States of America)\tEGFR c.2310 2311ins9 (Cell or Molecular Dysfunction)", + "output": "SMMHC (Cytoskeletal Proteins)" + }, + { + "input": "Definition: Medicinal product categorized by therapeutic role described as a class of drugs producing both physiological and psychological effects through a variety of mechanisms. They can be divided into \"specific\" agents, e.g., affecting an identifiable molecular mechanism unique to target cells bearing receptors for that agent, and \"nonspecific\" agents, those producing effects on different target cells and acting by diverse molecular mechanisms. Those with nonspecific mechanisms are generally further classed according to whether they produce behavioral depression or stimulation. Those with specific mechanisms are classed by locus of action or specific therapeutic use.\nConcepts: Acids, Boric (Boron Compounds)\tsystem ct scan (Medical Device)\tpharmacologic therapy (Functional Concept)\tblack spider (Organic Chemical)\tcns agents (Pharmacologic Substance)", + "output": "cns agents (Pharmacologic Substance)" + }, + { + "input": "Definition: Diet described as a typical, daily diet. In the United States a typical diet consists of about 2,200 calories per day, with 50% of calories from carbohydrates, 15% protein, and 35% fat.\nConcepts: Standard Diet (Diet)\tnegative regulation of RNA binding (regulation of RNA binding)\tBody Shape (Organism Attribute)\tD82 FAMILY ACERACEAE (Plant)\tCDISC ADAS-Cog - Constructional Praxis: Diamond (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Standard Diet (Diet)" + }, + { + "input": "Definition: Pharmacologic Substance described as a vaginal lubricant formulated as a topical gel used to prevent and treat vaginal dryness. With a pH similar to that of normal vaginal discharge, Clino-San vaginal lubricant may reduce dryness, pain and irritation often caused by insufficient vaginal discharge due to atrophy of the vulvovaginal mucosa. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C74018\" active clinical trials using this agent.\nConcepts: 8th (Disease Stage Qualifier)\tAB-928 (Immunologic Adjuvants)\tClino-San vaginal lubricant (Topical Preparation)\tGrade 4 Cholesterol high (Finding)\tActive Comparator (Clinical Study Element)", + "output": "Clino-San vaginal lubricant (Topical Preparation)" + }, + { + "input": "Definition: Arteritis described as an extremely uncommon form of vasculitis. Eleven documented cases have been reported in the literature, affecting older children and young adults. In contrast to the classic form of temporal arteritis, it is not a systemic disease nor does it cause local symptoms at the temporal area.The term juvenile temporal arteritis was coined by Lie and his colleagues, in 1975, when they reported four cases of an otherwise asymptomatic disease presenting with a painless nodule at the temporal region. None of the cases showed evidence of systemic disease or history of trauma to the temporal region. Excisional biopsy of the lesions revealed a non-giant cell granulomatous inflammation of the temporal arteries with eosinophilic infiltration, intimal proliferation and micro aneurysmal disruption of the media. The disease has a benign clinical course, is treated by surgical excision and does not recur.\nConcepts: Increased circulating antibody level (Abnormal immunoglobulin level)\tThea (Drink)\tOCULOPHARYNGODISTAL MYOPATHY (Blepharoptosis)\tMycobacterium tuberculosis hominis (Bacterium)\tNon-giant cell granulomatous temporal arteritis with eosinophilia (Granulomatous disorder)", + "output": "Non-giant cell granulomatous temporal arteritis with eosinophilia (Granulomatous disorder)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic organic compound that selectively inhibits the kinase activity of Mitogen-Activated Protein kinase, preventing cytokine and prostaglandin E2 production.\nConcepts: UO126 (Mitogen-Activated Protein Kinase Inhibitor)\tNanomole/hour (Quantitative Concept)\tFollistatin-Related Gene Protein (Binding Proteins)\tS phase (Interphase)\tAssignments, Medicare (Health Care Activity)", + "output": "UO126 (Mitogen-Activated Protein Kinase Inhibitor)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein].\nConcepts: acyl-ACP:lyso-MGDG acyltransferase activity (O-acyltransferase activity)\tExternal hemorrhoid (Disorder of vein)\tHereditary progressive mucinous histiocytosis (Non-Langerhans cell histiocytic dermatosis)\tAfrican Prunes (Prunus)\tStage II Vaginal Cancer (Vaginal Cancer by AJCC v7 Stage)", + "output": "acyl-ACP:lyso-MGDG acyltransferase activity (O-acyltransferase activity)" + }, + { + "input": "Definition: Bone absent described as absence of a lateral half (arch + hemicentrum) of a vertebra. Structural change involving the bone precursor. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)\nConcepts: Bone Surgery Saws (Surgical saw)\tUnresectable Inflammatory Breast Carcinoma (Unresectable Breast Carcinoma)\tST2 (Candidate Tumor Suppressor Gene)\thalf vertebra (Congenital anomaly of skeletal bone)\tInfantile spastic cerebral palsy (Muscle Spasticity)", + "output": "half vertebra (Congenital anomaly of skeletal bone)" + }, + { + "input": "Definition: something described as an observation of an individual's soft palate elevation during swallowing.\nConcepts: Pasteurella multocida (Lehmann and Neumann 1899) Rosenbusch and Merchant 1939 (Pasteurellaceae)\tQSSTRESN (Quantitative Concept)\tDolichyl Mannosyl Phosphate (Polyisoprenyl Phosphate Monosaccharides)\tocellus photoreceptor cell development (photoreceptor cell development)\tSoft Palate Elevation (Pharyngeal Impairment During Swallowing)", + "output": "Soft Palate Elevation (Pharyngeal Impairment During Swallowing)" + }, + { + "input": "Definition: something described as a validated risk prediction tool for patients with metastatic renal cell carcinoma (mRCC) receiving first-line targeted therapy. The model considers: Karnofsky performance status less than 80%, time from diagnosis to first-line targeted therapy less than 1 year, hemoglobin concentration less than lower limit of normal, neutrophil count greater than upper limit of normal, platelet count greater than upper limit of normal, and serum calcium concentration greater than upper limit of normal.\nConcepts: collagent type XII location (anchoring collagen complex)\tStage III Ampulla of Vater Neuroendocrine Tumor (Ampulla of Vater Neuroendocrine Tumor by AJCC v8 Stage)\tInternational Metastatic Renal Cell Carcinoma Database Consortium Criteria (Intellectual Product)\tIL27 gene (Interleukin Gene)\tOropharyngeal (p16-Negative) Carcinoma pN3b TNM Finding v8 (Oropharyngeal (p16-Negative) Cancer pN3 TNM Finding v8)", + "output": "International Metastatic Renal Cell Carcinoma Database Consortium Criteria (Intellectual Product)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bladder Version 4 (FACT-BL Version 4) Additional Concerns: I have diarrhea (diarrhoea).\nConcepts: FAC00632 (Intellectual Product)\tCanadians, Native (Indians, North American)\tstent (Medical Devices)\tVentral median fissure of spinal cord (Subarachnoid fissure)\tSkin Graft (Body Part, Organ, or Organ Component)", + "output": "FAC00632 (Intellectual Product)" + }, + { + "input": "Definition: Antibiotic described as a short-acting sulfonamide antibiotic and by-product of the non-steroidal anti-inflammatory drug sulfasalazine. Its manufacture and use were discontinued in 1990.\nConcepts: Sulfapyridine (sulfanilamide)\tRight hepatic lymph node (Body Part, Organ, or Organ Component)\tInflammation, Brain (Inflammation of specific body organs)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(12;21) (Medical Device)\tRestorative Material Kits, Dental, Porcelain Repair (Dental Materials)", + "output": "Sulfapyridine (sulfanilamide)" + }, + { + "input": "Definition: regulation of synapse organization described as a posttranscriptional regulation of gene expression that results in regulation of synapse organization.\nConcepts: HPOT1 (Gene or Genome)\tregulation of synapse organisation by posttranscriptional regulation of gene expression (posttranscriptional regulation of gene expression)\tFornix of brain (Diencephalon part)\tAPOMORPHINE HYDROCHLORIDE (Drug allergens)\tPTP(CAAX1) (Gene or Genome)", + "output": "regulation of synapse organisation by posttranscriptional regulation of gene expression (posttranscriptional regulation of gene expression)" + }, + { + "input": "Definition: Cell Component described as the lipid bilayer surrounding a vesicle transporting substances within the Golgi.\nConcepts: PE-1 (ETS Family Gene)\tAmyloidogenesis (Pathologic Processes)\tFACIT-F Version 4 - I Am Able to Work (Intellectual Product)\tinter-Golgi transport constitutive secretory pathway transport vesicle membrane (COPI-coated vesicle membrane)\tBALB C Mouse (Mice, Inbred Strains)", + "output": "inter-Golgi transport constitutive secretory pathway transport vesicle membrane (COPI-coated vesicle membrane)" + }, + { + "input": "Definition: something described as physical location of CDK2AP1_Gene\nConcepts: 12: 122281567-122270422 (Spatial Concept)\tnail disorder (Nail and nail bed conditions)\tApplies chemical hemostatic agents (Implementation of hemostasis techniques)\tCongenital megalourethra (Congenital Abnormality)\thexose (Organic Chemical)", + "output": "12: 122281567-122270422 (Spatial Concept)" + }, + { + "input": "Definition: something described as human MCM6 wild-type allele is located in the vicinity of 2q21 and is approximately 37 kb in length. This allele, which encodes DNA replication licensing factor MCM6 protein, is involved in the regulation of genomic replication.\nConcepts: Zinc Finger Protein 89B (Amino Acid, Peptide, or Protein)\tsielris/fan feng (Plant)\tresponse to heparin (Cell Function)\tTelecommunication Address Type (Type - attribute)\tMis5 (MCM6 gene)", + "output": "Mis5 (MCM6 gene)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as t-box transcription factor T (435 aa, ~47 kDa) is encoded by the human TBXT gene. This protein is involved in the regulation of both mesoderm development and transcription.\nConcepts: pleuropericarditis (Non-infectious pericarditis)\tFZR1 (Genes, Regulator)\tT-Box Transcription Factor T (Amino Acid, Peptide, or Protein)\tGamma-Chemokines (Amino Acid, Peptide, or Protein)\tNucleoside Diphosphate Kinase D (Amino Acid, Peptide, or Protein)", + "output": "T-Box Transcription Factor T (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Abnormality of the distal phalanx of the 3rd finger described as dissolution or degeneration of bone tissue of the distal phalanx of the 3rd finger.\nConcepts: Transmethylase, Homocysteine (Enzyme)\tLytic defect of terminal phalanx of middle finger (Abnormality of the distal phalanx of the 3rd finger)\tchromatin assembly factor 1 complex location (protein-containing complex)\tair indoor quality (Qualitative Concept)\tup regulation of penicillin synthesis (positive regulation of cellular biosynthetic process)", + "output": "Lytic defect of terminal phalanx of middle finger (Abnormality of the distal phalanx of the 3rd finger)" + }, + { + "input": "Definition: Spatial Concept described as the position and orientation of the image slice relative to the patient-based coordinate system.\nConcepts: Academic Dissertations (Publication Formats)\tWHODAS 2.0 12-item Version Proxy-administered - Washing His or Her Whole Body (WHODAS 2.0 12-item Version Proxy-administered Questionnaire Question)\tASEX02TC (Intellectual Product)\tMesocestoides (Eukaryote)\tAnatomical Plane (Spatial Concept)", + "output": "Anatomical Plane (Spatial Concept)" + }, + { + "input": "Definition: something described as a question about an individual's assessment of how often they have been bothered by emotional problems in the past seven days.\nConcepts: Eiken Type Chondrodysplasia (Rare Non-Neoplastic Disorder)\twet bed (Mental or Behavioral Dysfunction)\tIn the past 7 days, how often have you been bothered by emotional problems such as feeling anxious, depressed or irritable (Intellectual Product)\tfamily interventions (intervention by agent or context)\tElectrocardiogram Derived Flag (Derived Flag)", + "output": "In the past 7 days, how often have you been bothered by emotional problems such as feeling anxious, depressed or irritable (Intellectual Product)" + }, + { + "input": "Definition: something described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.\nConcepts: Tonsil suturing needle (Suture needle)\tBlood antidiuretic hormone abnormal (Finding)\tDefinedSubstanceAdministration.periodDoseTotal (Quantitative Concept)\tHemoglobin-Beta Locus (Gene or Genome)\tBISMARCK BROWN Y (Indicator, Reagent, or Diagnostic Aid)", + "output": "BISMARCK BROWN Y (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as test codes of questionnaire questions associated with the Columbia-Suicide Severity Rating Scale (C-SSRS) Baseline/Screening Version Phase 1 Study Version 1/14/09 for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: LC (Company)\tSerpulina murdochii Stanton et al. 1997 (Genus Brachyspira)\tColumbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study Questionnaire Test Code (CDISC Questionnaire Terminology)\tMicroinjectors (Injector)\tFAC03616 (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)", + "output": "Columbia-Suicide Severity Rating Scale Baseline/Screening Version Phase 1 Study Questionnaire Test Code (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP.\nConcepts: Photography, microscopic (Diagnostic Imaging)\tStage II Contiguous Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma (Ann Arbor Stage II Contiguous Adult Aggressive Non-Hodgkin Lymphoma)\tmyo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity (Molecular Function)\tRescue Medications (Pharmacologic Substance)\tMyxoid Liposarcoma of Ovary (Ovarian Liposarcoma)", + "output": "myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity (Molecular Function)" + }, + { + "input": "Definition: External Fixators described as systems of devices/components that are designed for external application for the purpose of stabilizing, holding and/or fastening (i.e., fixation) bones. External orthopedic fixation systems are used mainly for temporary stabilization of fractured and/or otherwise weakened bones during the healing process.\nConcepts: Laryngotracheal stenosis, arthropathy, prognathism and short stature (Autosomal dominant hereditary disorder)\tpyridoxamine binding (Molecular Function)\tnatural killer cell mediated immune response to tumor cell (immune response to tumor cell)\tLikely pathogenic (Nucleotide Sequence)\tOrthopedic External Fixation Systems (Medical Device)", + "output": "Orthopedic External Fixation Systems (Medical Device)" + }, + { + "input": "Definition: something described as moral principles of conducting professional research or practices.\nConcepts: Arterioles (ARTERIES: TYPE AND STRUCTURE)\tregulation of transcription initiation from RNA polymerase II promoter (regulation of transcription by RNA polymerase II)\torigin recognition complex subunit 5 (ORC Subunit Gene)\tethics professional (Idea or Concept)\tSFMP2-Throbbing Pain (Intellectual Product)", + "output": "ethics professional (Idea or Concept)" + }, + { + "input": "Definition: something described as the free part of the epithelium that faces the interior surface of the lumen of an organ or towards the interstitium.\nConcepts: Basal Domain of the Epithelium (Tissue)\tPersistent (modifier) (Temporal Concept)\tup regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway (positive regulation of intrinsic apoptotic signaling pathway)\tcellular response to IL-12 (Cell Function)\tFIQR01-Overwhelmed by Fibromyalgia (Intellectual Product)", + "output": "Basal Domain of the Epithelium (Tissue)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as zinc finger protein 423 (1284 aa, ~145 kDa) is encoded by the human ZNF423 gene. This protein is involved in differentiation of olfactory receptor neurons.\nConcepts: DDS02-Leave Home and Cannot Protect Him (Intellectual Product)\tlactone catabolic process (organic cyclic compound catabolic process)\tHCT-116 (NCI-60 Cell Line)\tfolate receptor-targeted epothilone BMS753493 (Epothilones)\tZinc Finger Protein 423 (TRANSCRIPTION FACTOR)", + "output": "Zinc Finger Protein 423 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: Rosaceae described as a plant species in the family ROSACEAE. It is the source of apricot fruit.\nConcepts: Stromal Hemosiderin Deposition (Hemosiderin pigmentation)\tpositive regulation of muscle atrophy (Physiologic Function)\tNotch homolog 2 (Drosophila) protein, human (receptor)\tPrior Primary Treatment (Other Finding)\tApricot Tree (Prunus)", + "output": "Apricot Tree (Prunus)" + }, + { + "input": "Definition: Organism Function described as any process that stops, prevents or reduces the frequency, rate or extent of phosphatidylcholine biosynthetic process.\nConcepts: negative regulation of phosphatidylcholine formation (negative regulation of phospholipid biosynthetic process)\tresponse to antidepressant (drug response)\tSystem, Social Support (SocCi)\tnegative regulation of folliculin secretion (negative regulation of response to drug)\tlab-based chem measurements fetal fibronectin (Laboratory Procedure)", + "output": "negative regulation of phosphatidylcholine formation (negative regulation of phospholipid biosynthetic process)" + }, + { + "input": "Definition: something described as systemic lupus erythematosus nephritis, with global or segmental subepithelial immune deposits or their morphologic sequelae by light microscopy and by immunofluorescence or electron microscopy, with or without mesangial alterations. (Weening, Jan J. et al. (2004). The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited. Journal of the American Society of Nephrology 15(2), 241-50.)\nConcepts: Family Atelidae (Anthropoidea)\tMovement Barrier (Finding)\tSystemic Lupus Erythematosus Nephritis Class V (Disease or Syndrome)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Streptokinase Antibody (Medical Device)\tTransmembrane O-Mannosyltransferase Targeting Cadherins 1 wt Allele (Gene or Genome)", + "output": "Systemic Lupus Erythematosus Nephritis Class V (Disease or Syndrome)" + }, + { + "input": "Definition: something described as entities sponsored by local hospitals, physician groups, and other licensed providers which are affiliated through common ownership or control and share financial risk whose purpose is to deliver health care services.\nConcepts: Tapering pointed ends of distal finger phalanges (Anatomical Abnormality)\tRegulation, Gene Expression, Viral (Gene Expression Regulation)\tOrganizations, Provider-Sponsored (Delivery of Health Care, Integrated)\tActinomycete Infections (Bacterial Infections)\tFanconi anemia complementation group J (Fanconi Anemia)", + "output": "Organizations, Provider-Sponsored (Delivery of Health Care, Integrated)" + }, + { + "input": "Definition: Refractory cancer described as malignant endocrine neoplasm that is resistant to treatment.\nConcepts: LACR1 (Gene or Genome)\tinterleukin-6-mediated signalling pathway (Cell Function)\tBiernacki Reaction (Single-Result Physical Property Test)\tTrimetrexato (Antiprotozoal Agents)\tRefractory Malignant Endocrine Neoplasm (Malignant neoplasm of endocrine gland)", + "output": "Refractory Malignant Endocrine Neoplasm (Malignant neoplasm of endocrine gland)" + }, + { + "input": "Definition: Laboratory Procedure described as providing an analysis of a client/patient's stool sample to assess his or her intestinal lysozyme levels. Service is billed per test.\nConcepts: UMS Gene Mutation (Gene Mutant)\tScaphoid-Radius Joint (Body Space or Junction)\tleukemia myelocytic (Leukemia)\tstrontium chromate (Hazardous or Poisonous Substance)\tintstinal lysozyme ea.tst (Laboratory Procedure)", + "output": "intstinal lysozyme ea.tst (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated - Dyskinesia: Hips, lower limbs, feet.\nConcepts: Bifidobacterium Orla-Jensen 1924 (Bacterium)\tRhonchi/wheezing (Added respiratory sounds)\tglucosamines (Over the counter healthfood/herbal products)\tESRSA121 (Intellectual Product)\tNucleic Acid Sequence Feature Type Code (Intellectual Product)", + "output": "ESRSA121 (Intellectual Product)" + }, + { + "input": "Definition: something described as physical location of GLMN_Gene\nConcepts: Unknown Primary Tumor cN2 TNM Finding v8 (Finding)\tDolosigranulum pigrum Aguirre et al. 1994 (Bacterium)\tGrade 1 Anxiety, CTCAE (Anxiety, CTCAE 3.0)\tregulation of shoot system development (Biologic Function)\t1: 92476565-92424068 (Spatial Concept)", + "output": "1: 92476565-92424068 (Spatial Concept)" + }, + { + "input": "Definition: Gene or Genome described as variants of proto-oncogenes that are members of the MYC family of early response genes, which encode regulatory proteins that act as homo- or hetero-dimers. These aberrant genes are activated by mutations or amplification, resulting in overexpression of the protein products. This can cause uncontrolled cell proliferation.\nConcepts: gamma-aminobutyric acid (GABA) B receptor, 2 protein, human (Receptor)\tScheduled Activity Status Change Reason Code (Status Change Reason Code)\tMYC-Family Oncogene (Oncogene, Transcription Factor)\tNeurokinin A (Laboratory Procedure)\t6p22 (Chromosome band)", + "output": "MYC-Family Oncogene (Oncogene, Transcription Factor)" + }, + { + "input": "Definition: Disease or Syndrome described as diffusely widened perivascular spaces in the basal ganglia, affecting especially the corpus striatum. Status cribrosum is usually symmetrical, with the perivascular spaces showing CSF signal and without diffusion restriction. The word cribriform means sievelike, with multiple perforations.\nConcepts: Status cribrosum (Abnormality of the basal ganglia)\tPediatric Quality of Life Neuromuscular Module Acute Version 3 Young Adult Parent Report Questionnaire Test Code (CDISC Questionnaire Terminology)\tstreptococcinum bacteria/str (Organic Chemical)\tdifferentially placenta 1 expressed protein (Gene or Genome)\tDocetaxel/Cisplatin (Therapeutic or Preventive Procedure)", + "output": "Status cribrosum (Abnormality of the basal ganglia)" + }, + { + "input": "Definition: something described as a group of nerve cells in the medulla ( Crosby-1962 ).\nConcepts: LINTUZUMAB (Antineoplastic Antibody)\tviral receptor activity (exogenous protein binding)\tmeta Iodobenzylguanidine (Sympathomimetics)\tamino acid adenylylation by nonribosomal peptide synthase (amino acid activation for nonribosomal peptide biosynthetic process)\tNucleus interfascicularis hypoglossi (Body Part, Organ, or Organ Component)", + "output": "Nucleus interfascicularis hypoglossi (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: negative regulation of wound healing described as any process that stops, prevents or reduces the frequency, rate or extent of epithelium regeneration.\nConcepts: inhibition of tetrapyrrole biosynthesis from glycine and succinyl-CoA (negative regulation of tetrapyrrole biosynthetic process)\tdownregulation of regeneration of epithelium (negative regulation of developmental growth)\tClonal evolution (Genetic Phenomena)\tficolin-1 rich granule (Cell Component)\tUrea, N-methyl-N-nitroso- (Organic Chemical)", + "output": "downregulation of regeneration of epithelium (negative regulation of developmental growth)" + }, + { + "input": "Definition: something described as a term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 6th edition.\nConcepts: Topical Solution/Cream/Gels, Injured Skin (Topical Solution/Cream/Gels)\tDNA polymerase delta 3, accessory subunit (Gene or Genome)\tPRTN3 wt Allele (Gene or Genome)\tGallbladder Cancer by AJCC v6 Stage (Neoplastic Process)\tCyclin D3 Protein Overexpression (Protein Deregulation)", + "output": "Gallbladder Cancer by AJCC v6 Stage (Neoplastic Process)" + }, + { + "input": "Definition: something described as nuclear receptor subfamily 1 group D member 1 (614 aa, ~67 kDa) is encoded by the human NR1D1 gene. This protein plays a role in transcriptional regulation of genes involved in metabolic processes and circadian rhythm.\nConcepts: Reagents, Quality Control, Immunodiagnostic (IVD Test Reagent/Kits, Immunoassay)\tIL18EXR (Excretion Rate)\tNuclear Receptor Subfamily 1 Group D Member 1 (Receptors, Nuclear)\tpomegranate juice (Food)\tN2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity (aminotransferase activity)", + "output": "Nuclear Receptor Subfamily 1 Group D Member 1 (Receptors, Nuclear)" + }, + { + "input": "Definition: Bibliographic Reference described as chemical measurement or determination.\nConcepts: FACT-BMT Version 4 - Get Emotional Support From Family (FACT-BMT Version 4 Questionnaire Question)\tGrade 2 Cushingoid (Finding)\tLilium (Liliaceae)\tAbnormality of limb epiphysis morphology (Anatomical Abnormality)\tChemical (Intellectual Product)", + "output": "Chemical (Intellectual Product)" + }, + { + "input": "Definition: Untreated Hairy Cell Leukemia described as a hairy cell leukemia requiring initial treatment because of the presence of signs of progression. Signs of progression include cytopenia (especially if symptomatic), increasing splenomegaly, and infectious complications. Therapy is not necessary if the patients are asymptomatic and the blood counts are maintained in an acceptable range.\nConcepts: HAI0101 (Intellectual Product)\tMoschcowitz Disease (CLOTTING DECREASED)\tProgressive Hairy Cell Leukemia Initial Treatment (Hairy Cell Leukemia)\tPeptidyl Arginine Deiminase Type II (Protein-arginine deiminase)\tSense of smell (Sensory Process)", + "output": "Progressive Hairy Cell Leukemia Initial Treatment (Hairy Cell Leukemia)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of hepatocellular carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.\nConcepts: HEALTH CARE ECON ORGAN (Italian translation of Medical Subject Headings)\tCFC1 wt Allele (Gene or Genome)\tRectal Solution (Biomedical or Dental Material)\tLiver Cell Carcinoma Pathologic Distant Metastasis TNM Finding v8 (Finding)\tTrypsin 1 and Trypsinogen 1 Measurement (Protein or Enzyme Type Measurement)", + "output": "Liver Cell Carcinoma Pathologic Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Anatomical Abnormality described as abnormality of the anal canal.\nConcepts: anus abnormality (Anatomical Abnormality)\tInsertion-Deletion Mutations (Mutation)\tSepto-Optic Dysplasia with Growth Hormone Deficiency (Structural brain disorders NEC)\tVirulizin (Immunologic Adjuvants)\tNo abdominal bruits (Finding)", + "output": "anus abnormality (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as the point in time that acts as a fixed reference point to a musculoskeletal finding.\nConcepts: ERK inhibitor LTT462 (Pharmacologic Substance)\tStage I (SIOP/COG/NWTSG Staging System)\tCA 125 (GENERAL ANTIGENS AND ANTIGENIC PHENOMENA)\tmultiple; neuritis (DISORDERS OF PERIPHERAL NERVOUS SYSTEM: GENERAL TERMS)\tMKTPTREF (Reference Time Point)", + "output": "MKTPTREF (Reference Time Point)" + }, + { + "input": "Definition: Osseous ankylosis described as a developmental defect leading to the union of two adjacent vertebrae.\nConcepts: Lateral Second Diagonal Branch Artery (Body Part, Organ, or Organ Component)\tSpinal fusion (Vertebral column)\tZinc Finger CCCH-type, RNA Binding Motif and Serine/Arginine Rich 2 Gene Nonsense Mutation (Cell or Molecular Dysfunction)\tCardiac Arrest Prior to Percutaneous Coronary Intervention (Finding)\tFat Droplet Measurement (Chemical procedure)", + "output": "Spinal fusion (Vertebral column)" + }, + { + "input": "Definition: something described as a statement about an electrocardiographic recording describing technical issues or interference during the recording, processing, or transmission of the data. This does not represent an electrocardiographic diagnosis.\nConcepts: Trapezoid Bone (Bone structure of carpus)\tFAC071-I Need to Sleep During the Day (Intellectual Product)\tPhyllobacteriaceae Mergaert and Swings 2006 (Alphaproteobacteria)\tTechnical Quality (ECG Measurement)\thRlf Beta Subunit (Biologically Active Substance)", + "output": "Technical Quality (ECG Measurement)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).\nConcepts: positive regulation of cumulus cell differentiation (positive regulation of epithelial cell differentiation)\trosa canina/wild rose (Flower Essences)\tGrade 2 Burn, CTCAE (Finding)\tL-kynurenine,NADPH:oxygen oxidoreductase (Molecular Function)\tng/mL/(ug/m2/d) (Quantitative Concept)", + "output": "L-kynurenine,NADPH:oxygen oxidoreductase (Molecular Function)" + }, + { + "input": "Definition: multicellular organismal process described as the process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.\nConcepts: amyloid-beta clearance (multicellular organismal process)\tImmediate Complete Dentures (Medical Device)\tFull (General Qualifier)\tTopical Myristyl Nicotinate Cream (Protective Agents)\tTNFRSF5 Receptor (Receptor)", + "output": "amyloid-beta clearance (multicellular organismal process)" + }, + { + "input": "Definition: QIDS-SR Questionnaire Question described as quick Inventory of Depressive Symptomatology Self-Report Version (QIDS-SR) Please circle the one response to each item that best describes you for the past seven days: General interest.\nConcepts: Focal impaired awareness perseverative automatism seizure (Focal impaired awareness automatism seizure)\tQIDSR1-General Interest (QIDS-SR Questionnaire Question)\tmesonephric smooth muscle tissue development (Organ or Tissue Function)\tKinase Suppressor of Ras (Adaptor Proteins, Signal Transducing)\tcalcarea fluorica/calcium fl (Pharmacologic Substance)", + "output": "QIDSR1-General Interest (QIDS-SR Questionnaire Question)" + }, + { + "input": "Definition: Target Anatomic Site Laterality Code described as a coded value specifying the side of the body (or a paired organ) that is a target site for an observation. EXAMPLE(S): bilateral, left, right OTHER NAME(S): NOTE(S): This attribute was deprecated in BRIDG 3.1 but undeprecated in 4.0 since source use cases for separate laterality include SDTM and CTOM. This change ensures that users of the BRIDG model are not bound to a particular kind of vocabulary, such as pre- or post-coordinated vocabularies. Collapsing laterality into the target site code is an implementation option.\nConcepts: regulation of hemopoietic stem cell proliferation (regulation of stem cell proliferation)\tDefined Observation Target Anatomic Site Laterality Code (Intellectual Product)\tOINTMENT (Type of drug preparation)\tAfrican green monkey (Cercopithecus)\ttebipenem pivoxil (Pharmacologic Substance)", + "output": "Defined Observation Target Anatomic Site Laterality Code (Intellectual Product)" + }, + { + "input": "Definition: something described as fragmented appearance of the epiphyses of the phalanges of the fingers.\nConcepts: Fragmentation of end part of finger bones (Abnormal epiphysis morphology of the phalanges of the hand)\toxamyl (Epichlorohydrin)\tIntrapelvic (Anatomy Qualifier)\tLaurales Juss. ex Bercht. & J.Presl, 1820 (Subclass Magnoliidae)\tProstate Cancer cTX TNM Finding v7 (Prostate Cancer Clinical Primary Tumor TNM Finding v7)", + "output": "Fragmentation of end part of finger bones (Abnormal epiphysis morphology of the phalanges of the hand)" + }, + { + "input": "Definition: something described as the inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.\nConcepts: 2-(Phenylsulfonylamino)-1,3,4-thiadiazole-5-sulfonamide (Carbonic Anhydrase Inhibitors)\tTanibirumab (Immunologic Factor)\tInner segment of photoreceptor (Cell Component)\tMycobacterium gastri (Nontuberculous Mycobacteria)\tstage IIIA pleural malignant mesothelioma AJCC v8 (Stage III Pleural Malignant Mesothelioma AJCC v8)", + "output": "Inner segment of photoreceptor (Cell Component)" + }, + { + "input": "Definition: something described as vaginal cancer with no evidence of primary tumor.\nConcepts: myopathy-lactic acidosis-sideroblastic anemia syndrome (Disease or Syndrome)\tWMS-IV Visual Reproduction I (Intellectual Product)\tSequences, mRNA Leader (Biologically Active Substance)\tMotor (Anatomy Qualifier)\tVaginal Cancer pT0 TNM Finding v7 (Finding)", + "output": "Vaginal Cancer pT0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as a rare syndromic form of cerebellar dysgenesis with characteristics of moderate to severe intellectual deficit and cerebellar abnormalities. OPHN1 syndrome is very rare. To date, up to 12 families have been reported. Affected male patients present moderate to severe intellectual disability, hypotonia, severe developmental delay, early-onset complex partial or tonic-clonic seizures, strabismus, dysmetria and occasionally ataxia. Cryptorchidism and genital hypoplasia have been reported. Various mutations including deletions and splice site mutations in the OPHN1 gene (Xq12) have been reported in patients with this syndrome. Transmission appears to follow an X-linked semi-dominant pattern.\nConcepts: Vagotomies, Proximal Gastric (Excision)\tOPHN1 syndrome (Intellectual Disability)\tMeaning (Idea or Concept)\tQLES186 (Intellectual Product)\tcellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process (Molecular Function)", + "output": "OPHN1 syndrome (Intellectual Disability)" + }, + { + "input": "Definition: Dog Breed described as small, affectionate, sociable and adaptable dogs that are popular with city dwellers because they make ideal apartment dogs. They are smart, full of energy and many have strong protective instincts.\nConcepts: Toy Breed (Dog Breed)\tHyperosmolar non-ketotic diabetic coma (Coma states)\tPower of muscles of one limb (Muscle power functions)\tPreliminary Data (Data Collection)\tPerformed Substance Administration Interruption Duration (Temporal Concept)", + "output": "Toy Breed (Dog Breed)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as the presence of mutations in both alleles of the ATM gene that either lead to loss of expression of the ATM protein or result in the translation of an inactive ATM protein.\nConcepts: Fast Neutrons (Quantitative Concept)\tcase mgmt (Health System Mediation)\tAtaxia Telangiectasia Mutated Biallelic Gene Inactivation (Cell or Molecular Dysfunction)\tFCR Regimen (Therapeutic or Preventive Procedure)\taorta abdominalis; aneurysm (Vascular disease of abdomen)", + "output": "Ataxia Telangiectasia Mutated Biallelic Gene Inactivation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a type 2A serotonin receptor.\nConcepts: PODCI2-Games Limited by: Too Young (Intellectual Product)\ttuberosa sclerosis (Skin and subcutaneous conditions NEC)\t5-hydroxytryptamine 2A receptor binding (Molecular Function)\tNeutral Sidebent Rotated (Pathologic Function)\tA Little Helpful (Intellectual Product)", + "output": "5-hydroxytryptamine 2A receptor binding (Molecular Function)" + }, + { + "input": "Definition: something described as a protein-bound iodine test system is a device intended to measure protein-bound iodine in serum. Measurements of protein-bound iodine obtained by this device are used in the diagnosis and treatment of thyroid disorders.\nConcepts: DRY ASH METHOD, PROTEIN-BOUND IODINE (Medical Device)\tProblem with Sleep (Intellectual Product)\tFormation, Erythrocyte Rouleaux (Cell Function)\tcell-mediated immunity (Immune status)\tErwinia amylovora (Burrill 1882) Winslow et al. 1920 (AL 1980) emend. Hauben et al. 1999 (Bacterium)", + "output": "DRY ASH METHOD, PROTEIN-BOUND IODINE (Medical Device)" + }, + { + "input": "Definition: Bronchiolar part of bronchial tree described as the narrowest airway of the bronchial tree, which is formed by the division of terminal bronchioles, and which contains alveoli along its wall for gas exchange.\nConcepts: Matrix Wedges, Dental (Dental Equipment and Supplies)\tupregulation of chemokine biosynthetic process (Cell Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CLN5 (Medical Device)\tRespiratory Bronchioles (Body Part, Organ, or Organ Component)\tfemale pregnancy (Biologic Development)", + "output": "Respiratory Bronchioles (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a triplet codon-amino acid adaptor activity that recognizes a CUG codon.\nConcepts: CTG codon-amino acid adaptor activity (triplet codon-amino acid adaptor activity)\tCURETTE, OPERATIVE (Medical Device)\tPODCI2-Friends Limited by: Not Around (Intellectual Product)\tstomachs (Foregut)\tCounseling;genetic (Therapeutic or Preventive Procedure)", + "output": "CTG codon-amino acid adaptor activity (triplet codon-amino acid adaptor activity)" + }, + { + "input": "Definition: Abnormal respiratory system morphology described as an abnormality of the pulmonary situs, i.e., of the sidedness of the morphological right and left lungs, which is defined by characteristics such as the number of lobes per lung and the relationship of the pulmonary arteries to their bronchi.\nConcepts: Parabacteroides johnsonii (Bacterium)\t(N-methylcarbamimidamido)acetic acid (Biologically Active Substance)\tnuclear euchromatin (Nuclear chromatin)\tAbnormal pulmonary situs morphology (Abnormal respiratory system morphology)\tComputational Intelligence (Computer software)", + "output": "Abnormal pulmonary situs morphology (Abnormal respiratory system morphology)" + }, + { + "input": "Definition: Medical Device described as a blood access device and accessories is a device intended to provide access to a patient's blood for hemodialysis or other chronic uses. When used in hemodialysis, it is part of an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and provides access to a patient's blood for hemodialysis. The device includes implanted blood access devices, nonimplanted blood access devices, and accessories for both the implanted and nonimplanted blood access devices. (1) The implanted blood access device consists of various flexible or rigid tubes, which are surgically implanted in appropriate blood vessels, may come through the skin, and are intended to remain in the body for 30 days or more. This generic type of device includes various shunts and connectors specifically designed to provide access to blood, such as the arteriovenous (A - V) shunt cannula and vessel tip. (2) The nonimplanted blood access device consists of various flexible or rigid tubes, such as catheters, cannulae or hollow needles, which are inserted into appropriate blood vessels or a vascular graft prosthesis (Secs. 870.3450 and 870.3460), and are intended to remain in the body for less than 30 days. This generic type of device includes fistula needles, the single needle dialysis set (coaxial flow needle), and the single needle dialysis set (alternating flow needle). (3) Accessories common to either type include the shunt adaptor, cannula clamp, shunt connector, shunt stabilizer, vessel dilator, disconnect forceps, shunt guard, crimp plier, tube plier, crimp ring, joint ring, fistula adaptor, and declotting tray (including contents).\nConcepts: STAPHYLOCOCCUS AUREUS SOMATIC ANTIGENS (Medical Device)\tDecreased Libido (Libido - finding)\tmonoclonal antibody GD2 anti-idiotype vaccine (Pharmacologic Substance)\tSynchronous (Synchronicities)\tCatheters, Femoral (Medical Device)", + "output": "Catheters, Femoral (Medical Device)" + }, + { + "input": "Definition: Abdomen described as any of the muscles of the abdomen that comprise the abdominal wall; these muscles include the rectus abdominis, the external and internal oblique muscles, the transversus abdominis, and the quadratus abdominis.\nConcepts: Progressive spinal muscular atrophy (Spinal Muscular Atrophy)\tdown-regulation of conjugation with cellular fusion (negative regulation of conjugation)\tabdominal muscles (Muscle)\tAnal Canal and Perianal (Anal Margin) Carcinoma pNX TNM Finding v8 (Finding)\torganic hydroxy compound anabolism (organic hydroxy compound metabolic process)", + "output": "abdominal muscles (Muscle)" + }, + { + "input": "Definition: Stage III Colon Cancer AJCC v7 described as stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.\nConcepts: parkin gene/protein (Enzymes)\tWelsh Corgi (Mammal)\tgeneration gap (Qualitative Concept)\tfamilial spastic paraplegia autosomal dominant type 37 (Pure hereditary spastic paraplegia)\tmalignant tumor of large intestine stage IIIc (Stage III Colon Cancer AJCC v7)", + "output": "malignant tumor of large intestine stage IIIc (Stage III Colon Cancer AJCC v7)" + }, + { + "input": "Definition: something described as the study of the structure and dynamics of computational systems using mathematical, logical, and empirical tools.\nConcepts: Adaptor Protein Gene (Signaling Pathway Gene)\tcomputer science (Occupation or Discipline)\tTask (Occupational Activity)\tRocker Boards (Balance board)\tFexofenadine HCl (Piperidine derivative antihistamine)", + "output": "computer science (Occupation or Discipline)" + }, + { + "input": "Definition: UML Entity described as listing of the genetic changes made deliberately in order to generate the animal model.\nConcepts: ELECTRODE, ION BASED, ENZYMATIC, CREATININE (Medical Device)\tvomeronasal-terminal nerve complex (Body Part, Organ, or Organ Component)\tPER1 (Regulatory Protein)\tGenotype Summary (UML Entity)\tRespirations, Artificial (Assisting)", + "output": "Genotype Summary (UML Entity)" + }, + { + "input": "Definition: Intellectual Product described as a citation in an external publication that refers to results of this study. NOTE(S): CT.gov instruction say to provide either the unique PubMed Identifier (PMID) of an article or enter the full bibliographic citation. \"Inbound\" references, could be to interim or final results, not a reference from this study to other studies.\nConcepts: Fructose Bisphosphatase (Enzymes)\tAbnormal tarsals (Finding)\tMagnetic Resonance Imaging with and without Contrast of Area of Interest (Diagnostic Procedure)\tCollagen Type VII (Biologically Active Substance)\tReferenceToStudyResults (Reference Document)", + "output": "ReferenceToStudyResults (Reference Document)" + }, + { + "input": "Definition: something described as the process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA.\nConcepts: L-theanine amidohydrolase activity (Molecular Function)\tprolyl-tRNA aminoacylation (Genetic Function)\tSomali wild ass (Mammal)\tType of Manufacturer Individual Case Safety Report Terminology (Intellectual Product)\tdisproportion of reconstructed breast (breast appearance - reconstruction)", + "output": "prolyl-tRNA aminoacylation (Genetic Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare, benign rheumatologic disorder or syndrome characterized by hyperostosis and soft tissue ossification between the clavicles and the anterior part of the upper ribs. It is often associated with the dermatologic disorder palmoplantar pustulosis, particularly in Japan. Careful diagnosis is required to distinguish it from psoriatic arthritis, OSTEITIS DEFORMANS, and other diseases. Spondylitis of pustulosis palmaris et plantaris is one of the possible causes; also, evidence suggests one origin may be bone infection. Bone imaging is especially useful for diagnosis. It was originally described by Sonozaki in 1974.\nConcepts: Dental Materials, Restorative, Mercury (Dental restorative material)\tSternocostoclavicular Hyperostoses (Rheumatism)\tPosterior Capsular Rupture, Ocular (Injury or Poisoning)\tSyphilis, Cutaneous (Sexually transmitted bacterial disease affecting skin)\tSystem Development, Musculoskeletal (Organ or Tissue Function)", + "output": "Sternocostoclavicular Hyperostoses (Rheumatism)" + }, + { + "input": "Definition: something described as a B7 antigen subtype that inhibits the costimulation of T-cell activation, proliferation, cytokine production and development of cytotoxicity. The over expression of this protein in a variety of tumor cell types suggests its role in TUMOR IMMUNE EVASION.\nConcepts: ecgonone methyl ester degradation (heterocycle catabolic process)\tAccessory medullary lamina of corpus striatum (Lamina of cerebral hemisphere)\tup regulation of histidine biosynthesis (Molecular Function)\tAutonomy, Personal (Freedom)\tV-Set Domain-Containing T-Cell Activation Inhibitor 1 (B7 Antigens)", + "output": "V-Set Domain-Containing T-Cell Activation Inhibitor 1 (B7 Antigens)" + }, + { + "input": "Definition: Gene or Genome described as human KLHL6 wild-type allele is located in the vicinity of 3q27.3 and is approximately 68 kb in length. This allele, which encodes kelch-like protein 6, may play a role in B-cell signaling.\nConcepts: Microorganism (CDISC SDTM Terminology)\tReal Time PCR Thermal Cyclers (Nucleic Acid Processors, Replication, Thermal Cycle)\tDNA 5'-adenylate hydrolase activity (Genetic Function)\tEvaluated Result Relationship Probability (Quantitative Concept)\tKelch-Like Family Member 6 wt Allele (Gene or Genome)", + "output": "Kelch-Like Family Member 6 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as unified Parkinson's Disease Rating Scale (UPDRS) Mentation, behavior and mood; depression.\nConcepts: Nuclear Receptor Corepressor 1 (Transcription Regulatory Protein)\tBPRSA114 (BPRS-A Clinical Classification Question)\tAngioplasties, Coronary Balloon (Myocardial Revascularization)\tUPD103 (Intellectual Product)\tInterventional Study Protocol Version Accepts Healthy Volunteers Indicator (Accepts Healthy Volunteers Indicator)", + "output": "UPD103 (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent.\nConcepts: Huntingtin-Interacting Protein 1 (Methyltransferase)\tStage I Thyroid Gland Follicular Cancer (Stage I Differentiated Thyroid Gland Carcinoma AJCC v8)\tChinese medicine Sheng-Yu-Tang (Immunologic Factor)\tCurie per Microgram (Quantitative Concept)\tCerivastatin product (C [Preparations])", + "output": "Cerivastatin product (C [Preparations])" + }, + { + "input": "Definition: Anatomical Abnormality described as abnormal concentration of lactate in the cerebrospinal fluid.\nConcepts: Hip Dysplasia, Beukes Type (Congenital anomaly of bone and joint)\tPercent Diameter Stenosis Measurement (Spatial Concept)\tregulation of establishment and maintenance of intracellular RNA localization (regulation of cellular localization)\tAbnormal CSF lactate level (Abnormal CSF metabolite level)\tschool learning (Mental Process)", + "output": "Abnormal CSF lactate level (Abnormal CSF metabolite level)" + }, + { + "input": "Definition: Organic Chemical described as conjugates of betalamic acid with AMINO ACIDS. Some of them are yellow COLORING AGENTS in the Caryophyllales order of PLANTS. This should not be confused with xanthin which is a term used for CAROTENES nor with XANTHINES.\nConcepts: route of administration oromucosal (Oral Route of Drug administration)\tStippling of the epiphyses of the 3rd finger (Epiphyseal stippling of finger phalanges)\tBetaxanthins (Organic Chemical)\tpolyadenylation-dependent ncRNA catabolic process (Genetic Function)\tBlades, Electric/Pneumatic Dermatome (Blades)", + "output": "Betaxanthins (Organic Chemical)" + }, + { + "input": "Definition: Breeding described as systematic approach to the development of genotype-dependent differences in a physical or behavioral trait. Compare ANIMAL BREEDING, ANIMAL DOMESTICATION, and EUGENICS.\nConcepts: GAIA Level 3a Prenatally Diagnosed Congenital Microcephaly (GAIA Prenatally Diagnosed Congenital Microcephaly Level of Diagnostic Certainty)\tSelective Breedings (Breeding)\tFACT-C Version 4 - I Worry About Dying (Intellectual Product)\tresponse to differentiation-inducing factor 2 (Organism Function)\tSmall cell carcinoma, fusiform cell type (Neuroendocrine tumor grade 3)", + "output": "Selective Breedings (Breeding)" + }, + { + "input": "Definition: Binding Proteins described as cohesin subunit SA-2 (1231 aa, ~141 kDa) is encoded by the human STAG2 gene. This protein is involved in chromosomal localization.\nConcepts: inhibition of cysteine-type endopeptidase activity involved in apoptotic process (Molecular Function)\tDDC wt Allele (Gene or Genome)\tclathrin coating of Golgi vesicle, plasma membrane to endosome targeting (Cell Function)\tStromal Antigen 2 (Binding Proteins)\tD-mannose 1,6-phosphomutase activity (Molecular Function)", + "output": "Stromal Antigen 2 (Binding Proteins)" + }, + { + "input": "Definition: Bacterium described as a species of aerobic or facultatively anaerobic, Gram-positive, coryneform, pleomorphic bacilli assigned to the phylum Actinobacteria. This species is nonmotile, non-spore forming, catalase positive, reduces nitrate, does not produce hydrogen sulfide, non-lipophilic, and is indole negative. C. matruchotii is present in human dental plaques.\nConcepts: Tibolone (T [Preparations])\tci (Quantitative Concept)\thelper t-cell (Lymphocyte)\tCYTOHISTOL PREP TECHNIQUE (Laboratory Procedure)\tBacterionema matruchotii (Mendel 1919) Gilmour et al. 1961 (Corynebacterium)", + "output": "Bacterionema matruchotii (Mendel 1919) Gilmour et al. 1961 (Corynebacterium)" + }, + { + "input": "Definition: Actinobacteridae described as a family of gram-positive bacteria found in soil and dairy products and as parasites on animals and man. Several are important pathogens.\nConcepts: YMRS01 (Intellectual Product)\tSuperficial Monoclonal Gastrointestinal Tract T-Cell Infiltrate Present (Abnormal Cells Present)\tFAMILY MYCOBACTERIACEAE (Actinobacteridae)\tlaser interstitial thermal therapy (Therapeutic or Preventive Procedure)\tmemantine hydrochloride (Alicyclic compound)", + "output": "FAMILY MYCOBACTERIACEAE (Actinobacteridae)" + }, + { + "input": "Definition: Physical Comfort Promotion described as attuning to the universal energy field by seeking to act as a healing influence using the natural sensitivity of hands and passing them over the body to gently focus, direct, and modulate the human energy field\nConcepts: Native American Healing sucking therapy individual each 15 minutes (Health Care Activity)\tTouch (Therapeutic tactile stimulation)\tCairn terrier (Canis familiaris)\tDurvalumab-containing product (Pharmacologic Substance)\tmultiple spine synapse organization, single dendrite (Cell Function)", + "output": "Touch (Therapeutic tactile stimulation)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.\nConcepts: Administrative Error (Clinical or Research Assessment Answer)\tDetection of sound (nervous system process)\tprotein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity (sucrose transmembrane transporter activity)\taminopeptidase activity (Molecular Function)\tCitrulline Test (biochemical test)", + "output": "protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity (sucrose transmembrane transporter activity)" + }, + { + "input": "Definition: something described as common name: R553X\nConcepts: Breast Carcinoma, Inflammatory (malignant neoplasm of breast staging)\tCaT regimen (Regimen Used to Treat Endometrial Carcinoma)\tTissue Oximetry Bedside Physiologic Monitors (Medical Device)\tc.1657C>T (Finding)\tprostanoid IP receptor binding (prostanoid receptor binding)", + "output": "c.1657C>T (Finding)" + }, + { + "input": "Definition: Finding described as a culture negative neonatal sepsis adverse event in a newborn which results in death.\nConcepts: Penicillin Amidohydrolase (Enzyme)\tElevated brain choline level by MRS (Abnormal brain choline level by MRS)\tPeriocular infection (BODY AS A WHOLE - GENERAL DISORDERS)\tClass III Angina (Canadian Cardiovascular Society Grading Scale Class)\tGrade 5 Culture Negative Neonatal Sepsis (Finding)", + "output": "Grade 5 Culture Negative Neonatal Sepsis (Finding)" + }, + { + "input": "Definition: Neoplastic Process described as stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: proteolipid (Amino Acid, Peptide, or Protein)\tStage 0 Paranasal Sinus Cancer (Stage 0 Nasal Cavity and Paranasal Sinus Cancer AJCC v6, v7, and v8)\tJNK STIMULATORY PHOSPHATASE 1 (Protein Phosphatase Gene)\tRheb Protein (Monomeric GTP-Binding Proteins)\tMajor Salivary Gland Cancer cN2a TNM Finding V8 (Major Salivary Gland Cancer cN2 TNM Finding V8)", + "output": "Stage 0 Paranasal Sinus Cancer (Stage 0 Nasal Cavity and Paranasal Sinus Cancer AJCC v6, v7, and v8)" + }, + { + "input": "Definition: Functional Concept described as the investigation involved the analysis of historical adverse events data of the actual device involved in the adverse event and/or of products from the same and/or different batches/lots.\nConcepts: Historical Data Analysis (Functional Concept)\tKrebs Cycle (Biochemical Processes)\tSolutions, Saline Hypertonic (Irrigation Solutions)\tDefinedObservationResult.targetAnatomicSiteLateralityCode (Target Anatomic Site Laterality Code)\tnicotine (Cholinergic receptor stimulating agent)", + "output": "Historical Data Analysis (Functional Concept)" + }, + { + "input": "Definition: something described as non-payable G-code for reporting functional limitation on physical therapy claim form\nConcepts: NP 000537.3:p.Arg213Gln (TP53 Protein Variant)\tgeranial dehydrogenase activity (Molecular Function)\tVoice (Intellectual Product)\tAbsent pinky finger (Aplasia/Hypoplasia of the 5th finger)\tMedian Nerve Neuropathy (Neuropathy of upper limb)", + "output": "Voice (Intellectual Product)" + }, + { + "input": "Definition: Qualitative Concept described as specifies whether the material is real (actual) vs. placeholder (kind of).\nConcepts: Material Actual Indicator (Actual Indicator)\tregulation of coenzyme metabolic process (regulation of cofactor metabolic process)\turacil breakdown (drug catabolic process)\tSAGA complex location (Cell Component)\tHSP 70 (Biologically Active Substance)", + "output": "Material Actual Indicator (Actual Indicator)" + }, + { + "input": "Definition: Neisseria described as a species of aerobic, Gram-negative, diplococci shaped bacteria assigned to the phylum Proteobacteria. This species is oxidase and catalase positive, grows best on blood agar medium or chocolate medium, is non-hemolytic, produces acid from glucose, but not from maltose, fructose, sucrose, mannose or lactose, does not synthesize polysaccharides, and reduces nitrite but not nitrate. N. gonorrhoeae is the causative agent of gonorrhea and is transmitted via sexual contact.\nConcepts: 10E7 Cells/kg (Quantitative Concept)\tPsychomotor Performance (Specific mental functions)\tInclusions, Cytoplasmic (Cardinal cell part)\tCESTTPT (Reference Start Time Point)\tgonorrheae neisseria (Gram-negative diplococcus)", + "output": "gonorrheae neisseria (Gram-negative diplococcus)" + }, + { + "input": "Definition: Medical Device described as single-bladder cuffs intended for a single-use (i.e., disposable) including an inflatable bladder and a contoured cuff that has a smaller diameter distally than proximally when wrapped. The cuffs are designed to exert a pressure on the circumference of an extremity by means of a compressed gas delivered by a pneumatic tourniquet. These devices usually include one bladder within the cuff that is inflated through tubes (e.g., hoses) that run from the bladder connectors to the source of compressed air located in the control unit of the tourniquet. The cuff is fastened to the extremity using contact mechanisms (e.g., clips) and frequently secured with an external ribbon. Contoured cuffs have an arced design to give them the smaller distal diameter when wrapped; some cuffs include pivoting fastening straps to allow adjustment of both distal and proximal diameters to suit the limb providing also more comfort to patients. Disposable single-bladder contoured cuffs are usually supplied sterile in individual pouches for only one use and are not intended for sterilization processes at the healthcare facility; they are usually made as an integral unit with components (e.g., bladder) that cannot be replaced. Single-bladder contoured cuffs are used mainly during surgical procedures in the extremities for patients who are obese or extremely muscular thus enabling surgeons to perform delicate procedures in bloodless operative fields. Contoured single-bladder cuffs (both reusable and disposable) intended for use on specific extremity areas (e.g., arm, thigh) are also available.\nConcepts: CETP (Laboratory Procedure)\tNon-synonymous JAK Family Gene Mutation (Cell or Molecular Dysfunction)\tALVAC-B7-CEA (Pharmacologic Substance)\tCuffs, Pneumatic Tourniquet, Single Bladder, Contoured, Disposable (Medical Device)\tGrade 1 Anal Mucositis, CTCAE (Anal Mucositis, CTCAE)", + "output": "Cuffs, Pneumatic Tourniquet, Single Bladder, Contoured, Disposable (Medical Device)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of etoposide, ifosfamide, cisplatin, and bleomycin that may be used in the treatment of certain germ cell tumors.\nConcepts: HLA Class II Histocompatibility Antigen DRB (Immunologic Factor)\tpyrimidine nucleoside transport (nucleoside transport)\tVIP-B Regimen (Chemo/immuno/hormone Therapy Regimen)\tBusiness Personnel (Personnel)\tBenign Thecal Cell Neoplasm of Ovary (Neoplastic Process)", + "output": "VIP-B Regimen (Chemo/immuno/hormone Therapy Regimen)" + }, + { + "input": "Definition: Chemical Phenomena described as the formation of a solid in a solution as a result of a chemical reaction or the aggregation of soluble substances into complexes large enough to fall out of solution.\nConcepts: Ryanodine Receptor (Amino Acid, Peptide, or Protein)\tCortex (Parietal Lobe)\tPrecipitation, Chemical (Natural Phenomenon or Process)\tPEPN (Gene or Genome)\tUnspecified non-Independent Data Monitoring Committee Document (Document type)", + "output": "Precipitation, Chemical (Natural Phenomenon or Process)" + }, + { + "input": "Definition: something described as metalloendopeptidases which convert BIG ENDOTHELIN to ENDOTHELIN-1.\nConcepts: ELAV-Like Protein 2 (Amino Acid, Peptide, or Protein)\tSCANNING ELECTRON MICROSCOPY (ObservationMethod - CodeSystem)\tDirect Cost (Quantitative Concept)\tPulp Stones, Dental (Disorder of face)\tEndothelin-Converting Enzyme (Metalloendopeptidases)", + "output": "Endothelin-Converting Enzyme (Metalloendopeptidases)" + }, + { + "input": "Definition: something described as a population of frozen, off-the-shelf, ready to administer, allogeneic, partially or closely human leukocyte antigen (HLA) matched cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad; AdV), with potential immunomodulating and anti-adenoviral activities. Ex vivo, Ad-derived peptides were mixed with peripheral blood mononuclear cells (PBMCs) from healthy donors and the Ad-reactive CTLs were selected, grown and frozen. Upon thawing and infusion, the partially HLA-matched Ad-specific CTLs may help reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections after allogeneic stem cell transplant (HSCT) or in Ad-infected immunocompromised hosts. This may induce killing of Ad-infected cells and may prevent or reduce severity of Ad infection.\nConcepts: Partially HLA-matched Ad-specific CTLs (Allogeneic Lymphocyte)\tMultiple sclerosis - MS (Diagnosis/Diseases Component)\tIntrauterine Growth Retardation (Finding)\tPleuropneumonia arthritidis muris (Mycoplasma)\tTransposition of Great Arteries (Congenital malformation of the great arteries)", + "output": "Partially HLA-matched Ad-specific CTLs (Allogeneic Lymphocyte)" + }, + { + "input": "Definition: Medical Device described as immunoassay reagents intended to perform qualitative analyses on a body fluid sample (typically serum or urine) to determine benzodiazepines and/or their metabolites in a short period of time, typically several minutes. Reagents for rapid determination of benzodoazepines are used in tests intended to diagnose and manage benzodiazepine intoxication caused by intentional or, less frequently, accidental ingestion, especially in emergency situations.\nConcepts: 5: 172130809-172127707 (Chromosome 5 Physical Location)\tAnalytical Grid Service (Machine Activity)\tN,N-Dimethylethanolamine (Ethanolamines)\tIVD Test Reagent/Kits, Immunoassay, Rapid Test, Drug-of-Abuse, Benzodiazepine/Metabolite (Medical Device)\tTRK1 Gene Rearrangement (Receptor Tyrosine Kinase Gene Rearrangement)", + "output": "IVD Test Reagent/Kits, Immunoassay, Rapid Test, Drug-of-Abuse, Benzodiazepine/Metabolite (Medical Device)" + }, + { + "input": "Definition: Hydrolase Gene described as this gene is involved in both the activation and detoxification of xenobiotics.\nConcepts: h*ug/mL/(mg/g/day) (Measurement Unit Description)\tEPOX (Hydrolase Gene)\tDecreased circulating A-type natriuretic peptide level (Finding)\tLevel 2 Low Birth Weight (Intellectual Product)\tLND (Radiation-Sensitizing Agents)", + "output": "EPOX (Hydrolase Gene)" + }, + { + "input": "Definition: Glucocorticoids described as a sodium phosphate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones.\nConcepts: Computer System or Software Supplier (Professional or Occupational Group)\tGrade 4 Ovarian rupture (Finding)\tup-regulation of granulocyte macrophage colony-stimulating factor production (Organism Function)\tdexamethasone sod phosphate (Organic Chemical)\tCELLULAR (Anatomy Qualifier)", + "output": "dexamethasone sod phosphate (Organic Chemical)" + }, + { + "input": "Definition: Microtubules described as any microtubule in the nucleus of a cell.\nConcepts: nuclear microtubule (Microtubules)\tpeptide cross-linking via L-cysteinyl-L-selenocysteine (peptidyl-selenocysteine modification)\tCraniofacial Dysostosis Syndromes (Congenital anomaly of face)\tmolybdenum incorporation via L-cysteinyl molybdopterin (molybdenum incorporation into molybdenum-molybdopterin complex)\tLattice corneal dystrophy Type II (Autosomal dominant hereditary disorder)", + "output": "nuclear microtubule (Microtubules)" + }, + { + "input": "Definition: cytoplasmic chromosome described as a circular DNA molecule containing plastid encoded genes.\nConcepts: Grade 2 Flushing, CTCAE (Finding)\tADACTYLY (Congenital Abnormality)\tprotein localization to cell periphery (Cell Function)\tCASP7 protein (Caspases, Effector)\tplastid chromosome (Cell Component)", + "output": "plastid chromosome (Cell Component)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Check all that were used: power tool (s).\nConcepts: Cell Movement (Cell Movement Process)\tStage II Intrahepatic Cholangiocarcinoma AJCC v8 (Stage II Intrahepatic Bile Duct Cancer AJCC v8)\tRosenberg (Intellectual Product)\tADL03-Appliance: Power Tools (Intellectual Product)\tDisapproval (Action)", + "output": "ADL03-Appliance: Power Tools (Intellectual Product)" + }, + { + "input": "Definition: UML Entity described as allows specification of the type of Reporter Design Element.\nConcepts: Reporter Group (UML Entity)\tInferior Palpebral Fold (Head and Neck Part)\tKRAS1 c.182A>G (KRAS Exon 3 Mutation)\tSaint Mary's Thistle Extract (M [Preparations])\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue, Scleroderma-70 Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue)", + "output": "Reporter Group (UML Entity)" + }, + { + "input": "Definition: something described as a unique symbol that establishes identity of the cancer registry. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: negative regulation of CAMKK-AMPK signaling cascade (negative regulation of calcium-mediated signaling)\tMembrane attack complex (Complement System Proteins)\tCancerRegistry.identifier (Identifier)\tDistal Bile Duct Cancer pN1 TNM Finding v8 (Finding)\tAngiosarcoma Associated with Lymphedema (Neoplastic Process)", + "output": "CancerRegistry.identifier (Identifier)" + }, + { + "input": "Definition: Bona fide anatomical surface described as anatomical surface, which is the external surface of a subdivision of a solid organ or the external or internal surface of a subdivision of a cavitated organ. Examples: Surface of lower lobe of right lung, surface of cervical part of esophagus, surface of body of vertebra, internal surface of fundus of stomach.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ABCA4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tDyskeratosis Congenita, X Linked (Disease or Syndrome)\tSurface of region of organ (Bona fide anatomical surface)\tIntermediate Cell Type Choroid Melanoma (Malignant melanoma of choroid)\tClino-San Vaginal Lubricant (Pharmacologic Substance)", + "output": "Surface of region of organ (Bona fide anatomical surface)" + }, + { + "input": "Definition: Sideroblastic anemia described as a type of sideroblastic anemia that is not responsive to treatment.\nConcepts: CIDP (Inflammatory neuropathy)\tRefractory sideroblastic anemia (Sideroblastic anemia)\tpositive regulation of actin filament polymerization involved in sperm capacitation (positive regulation of actin filament polymerization)\tChelion (Anatomical point of face)\tEstramustine-Etoposide Regimen (Therapeutic or Preventive Procedure)", + "output": "Refractory sideroblastic anemia (Sideroblastic anemia)" + }, + { + "input": "Definition: Pharmacologic Substance described as a natural tocopherol with less antioxidant activity than ALPHA-TOCOPHEROL. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in BETA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.\nConcepts: gamma tocopherol (vitamin E)\tDevice Unsafe to Use in Environment (Environmental Compatibility Problem)\tregulation of timing of anagen (Physiologic Function)\tPatchy variation in bone mineral density (Reduced bone mineral density)\tPlasmacytoma-Like Post-Transplant Lymphoproliferative Disorder (Plasma Cell Post-Transplant Lymphoproliferative Disorder)", + "output": "gamma tocopherol (vitamin E)" + }, + { + "input": "Definition: Glycerophospholipids described as a component of PHOSPHATIDYLCHOLINES or LECITHINS, in which the two hydroxy groups of GLYCEROL are esterified with fatty acids.\nConcepts: Paramembranous ventricular septal defect (Heart)\tSerous pericardium of ascending aorta (Body Location or Region)\tglycerol-3-phosphocholine (Biologically Active Substance)\tHL-20 (Gene or Genome)\tBPI123B (BPI Questionnaire Question)", + "output": "glycerol-3-phosphocholine (Biologically Active Substance)" + }, + { + "input": "Definition: something described as an increase in size, volume, quantity or scope in comparison to a previous enlarged state.\nConcepts: Further Enlargement (Enlargement procedure)\turidine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II activity (acetylgalactosaminyltransferase activity)\tiron-sulphur cluster binding (metal cluster binding)\taryl-alcohol dehydrogenase (NADP+) activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tTrisomy of Both Chromosomes 4 and 10 (Cell or Molecular Dysfunction)", + "output": "Further Enlargement (Enlargement procedure)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Pediatric Parent-Reported Version (PODCI Pediatric Parent-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 60 above, was your child's activity limited by: Fear the other kids won't like him/her?\nConcepts: thigmotropism (Organism Function)\tLumbosacral Orthoses (Medical Device)\tABA-GE beta-glucosidase activity (Molecular Function)\tPODCI1-Friends Limited by: Fear (Intellectual Product)\tCOWAT104 (COWAT Functional Test Question)", + "output": "PODCI1-Friends Limited by: Fear (Intellectual Product)" + }, + { + "input": "Definition: signaling receptor binding described as interacting selectively and non-covalently with a growth factor receptor.\nConcepts: Oedema of the basal ganglia (Abnormality of the basal ganglia)\tregulation of retinoic acid biosynthetic process (regulation of lipid biosynthetic process)\tRSRPNUM (Quantitative Concept)\tgrowth factor receptor binding (Molecular Function)\tNasopharyngeal Cancer Clinical TNM Finding v7 (Finding)", + "output": "growth factor receptor binding (Molecular Function)" + }, + { + "input": "Definition: Kidney Diseases described as distention of the pelvis and calices of the kidney with urine, as a result of obstruction of the ureter, with accompanying atrophy of the parenchyma of the organ.\nConcepts: DNA-directed RNA polymerase II, holoenzyme (Cell Component)\tHydronephrosis (STRUCTURAL URINARY TRACT)\tSertoli Cell Tumor of the Testis (Primary malignant neoplasm of testis)\tsmooth muscle cell differentiation (muscle cell differentiation)\tCSS0108 (C-SSRS Baseline Questionnaire Question)", + "output": "Hydronephrosis (STRUCTURAL URINARY TRACT)" + }, + { + "input": "Definition: Soft tissue lesion described as excess deposit and expansion of adipose tissue in an unusual pattern which cannot be lost through diet and exercise .\nConcepts: Relational Operator (HL7 Vocabulary Version 2.5)\tOcular (Functional Concept)\tUNC13B wt Allele (Gene or Genome)\tISMETHOD (Test Method)\tlipoedema (Lymphedema)", + "output": "lipoedema (Lymphedema)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents used in immunological tests to determine one or more of the alleles of the cell-surface proteins coded in the locus DQ of the class II genes of the major histocompatibility complex. These tests are mostly used to match donor and recipient tissues before transplants (e.g., kidney, medulla). Several alleles (e.g., DQ7) are associated with immune diseases.\nConcepts: Sacro-iliac joints: pain elicited by stress-test (Sign or Symptom)\tBRF1 (BRF1 gene)\tBirt-Hogg-Dub\u00e9 Syndrome (Skin Diseases, Genetic)\tIVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II, DQ Loci (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II)\tnegative regulation of mast cell activation involved in immune response (regulation of mast cell activation involved in immune response)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II, DQ Loci (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II)" + }, + { + "input": "Definition: Enzyme described as e3 ubiquitin-protein ligase TRIM36 (728 aa, ~83 kDa) is encoded by the human TRIM36 gene. This protein is involved in the regulation of protein degradation.\nConcepts: CES01-Ever Surrounded by the Enemy (CES Questionnaire Question)\tyW biosynthetic process (tRNA modification)\tRING Finger Protein 98 (Amino Acid, Peptide, or Protein)\tMSQL1-Amt Time Interfere Social Activity (MSQOL-54 Questionnaire Question)\tActivating RAF Mutation (RAF Family Gene Mutation)", + "output": "RING Finger Protein 98 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated\nConcepts: Bladder Carcinoma pT4a TNM Finding v8 (Bladder Cancer pT4 TNM Finding v8)\tGrade 4 Hepatic hemorrhage (Finding)\tPARK2 (Gene Mutation)\tVelocity Encoding Minimum Value (Qualitative Concept)\tKnowledge: Asthma Management (Knowledge Health Condition)", + "output": "Grade 4 Hepatic hemorrhage (Finding)" + }, + { + "input": "Definition: Organic Chemical described as a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by the Aspergillus flavus group of fungi. It is also mutagenic, teratogenic, and causes immunosuppression in animals. It is found as a contaminant in peanuts, cottonseed meal, corn, and other grains. The mycotoxin requires epoxidation to aflatoxin B1 2,3-oxide for activation. Microsomal monooxygenases biotransform the toxin to the less toxic metabolites aflatoxin M1 and Q1.\nConcepts: b1 aflatoxin (A [Preparations])\tUrochordates (Chordata, Nonvertebrate)\tCohort Study (Longitudinal Studies)\ttransport of peptides or proteins into host cell cytoplasm (Cell Function)\tPrimary Ectopic Meningioma of Ethmoidal Sinus (Neoplastic Process)", + "output": "b1 aflatoxin (A [Preparations])" + }, + { + "input": "Definition: plasma membrane protein complex described as a protein complex that contains Grb2, the adaptor protein Shc and the guanine nucleotide exchange factor Sos (or an ortholog thereof, such as mSos1), and is involved in linking EGFR activation to the p21-Ras pathway.\nConcepts: German Shepherd (Dog family)\tgalactolipid metabolism (glycolipid metabolic process)\tMLH1 (Laboratory Procedure)\tShc-Grb2-Sos complex (Cell Component)\tCXC Cytokine Gene (Gene or Genome)", + "output": "Shc-Grb2-Sos complex (Cell Component)" + }, + { + "input": "Definition: something described as RAND 36-Item Health Survey 1.0 (RAND-36) How much of the time during the past 4 weeks: Have you felt so down in the dumps that nothing could cheer you up?\nConcepts: C1-C2 subluxation (Cervical subluxation)\tStage I Cervical Cancer AJCC v8 (Cervical Cancer by AJCC v8 Stage)\tdownregulation of microtubule nucleation (regulation of microtubule nucleation)\tIPA03-Sitting Weekday Hours per Day (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tRAND-36 - Felt Nothing Could Cheer You Up (RAND-36 Questionnaire Question)", + "output": "RAND-36 - Felt Nothing Could Cheer You Up (RAND-36 Questionnaire Question)" + }, + { + "input": "Definition: Bacterium described as a genus of Gram-negative, non-spore forming rod-shaped bacteria in the phylum Proteobacteria.\nConcepts: shigellas (Salmonella)\tPlanned Study Site Duration (Temporal Concept)\tpeptidyl-serine O-acetylation (Molecular Function)\tN-(4-((4-(Cyclopropylmethyl)-1-piperazinyl)carbonyl)phenyl)-8-quinolinesulfonamide (Agent Affecting Blood or Body Fluid)\tNeoplastic Status (Intellectual Product)", + "output": "shigellas (Salmonella)" + }, + { + "input": "Definition: Laboratory Procedure described as a classification of the amount of Mucor racemosus antigen IgE antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen.\nConcepts: Tilia vulgaris (Plant)\tacute alcohol intoxication (Intoxication)\tHYPERTENSION OCULAR (Eye)\tVaccenic acid (5-octadecenoic acid)\tMucor racemosus IgE RAST Score (Immunoglobulin E measurement)", + "output": "Mucor racemosus IgE RAST Score (Immunoglobulin E measurement)" + }, + { + "input": "Definition: Congenital Disorders described as congenital severe form of flatfoot involving dislocation of the NAVICULAR BONE OF FOOT on the TALUS.\nConcepts: Up-front Treatment (Therapeutic procedure)\tJTMIN (Quantitative Concept)\tCVT - Congenit vertical talus (Musculoskeletal and connective tissue disorders of limbs congenital)\tCentrally nucleated skeletal muscle fibers (MUSCLE SOFT, TISSUE)\tUltrasonic wave (Sound - physical agent)", + "output": "CVT - Congenit vertical talus (Musculoskeletal and connective tissue disorders of limbs congenital)" + }, + { + "input": "Definition: dental agent described as preparations used for cleansing teeth; they usually contain an abrasive, detergent, binder and flavoring agent and may exist in the form of liquid, paste or powder; may also contain medication and caries preventives.\nConcepts: Cell Differentiation Inhibition (regulation of cell differentiation)\tDentifrices (Dental Materials)\tStudyPersonnel.primaryIndicator (Qualitative Concept)\tVery Fast Growing (Property or Attribute)\tprostatitis (Prostate Non-Neoplastic Disorder)", + "output": "Dentifrices (Dental Materials)" + }, + { + "input": "Definition: Document type described as a detailed record of a surgical procedure by the clinician who performed the operation.\nConcepts: FAMOTIDINE (Thiazoles)\tCell, Granulocytic Precursor (Cell)\thypophosphite dioxygenase activity (2-oxoglutarate-dependent dioxygenase activity)\tRubivirus (Rubivirus)\tOperative Report (Document type)", + "output": "Operative Report (Document type)" + }, + { + "input": "Definition: Methylobacterium described as any bacterial organism that can be assigned to the species Methylobacterium mesophilicum.\nConcepts: 9H-Purine-6Thio-98D (Purine antagonist)\tSaint Jude Children's Research Hospital (Health Care Related Organization)\tIleocolic Vein (Structure of tributary of superior mesenteric vein)\tSpray Suspension Dosage Form (Suspensions)\tPseudomonas mesophilica (Methylobacterium)", + "output": "Pseudomonas mesophilica (Methylobacterium)" + }, + { + "input": "Definition: Neoplastic Process described as a disease in which too many neutrophils (a type of white blood cell) are found in the blood. The extra neutrophils may cause the spleen and liver to become enlarged. Chronic neutrophilic leukemia may stay the same for many years or it may progress quickly to acute leukemia.\nConcepts: CRVT - Central retinal vein thrombosis (Venoocclusive disease)\tbeta-nerve growth factor production (neurotrophin production)\tadenoma apocrine (Benign skin tumor with apocrine differentiation)\tLeukemias, Chronic Neutrophilic (Myeloproliferative disease)\tSex cord stromal tumor (Neoplasm, uncertain whether benign or malignant)", + "output": "Leukemias, Chronic Neutrophilic (Myeloproliferative disease)" + }, + { + "input": "Definition: regulation of smooth muscle contraction described as any process that modulates the frequency, rate or extent of smooth muscle contraction involved in micturition.\nConcepts: regulation of smooth muscle contraction involved in micturition (Organ or Tissue Function)\tprocedure anesthesia (Administration of medication)\tPyroglutamic Acid (glutamic acid)\tRisk Evaluation and Mitigation Strategies Counsel Patient (Health Care Activity)\tTumor-Adjacent Normal Specimen (Biospecimen)", + "output": "regulation of smooth muscle contraction involved in micturition (Organ or Tissue Function)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) If yes, check household appliances that apply: microwave.\nConcepts: Male Gonadectomy (TESTIS AND EPIDIDYMIS: EXCISIONS)\tAbnormal urine Na concentration (Abnormal urinary electrolyte concentration)\tHydrazide, Isonicotinic Acid (Nitrogen and nitrogen compound)\tDIPYRIDAMOLE (Adenosine Deaminase Inhibitors)\tADCS-ADL MCI - Use Household Appliance: Microwave (ADCS-ADL MCI Questionnaire Question)", + "output": "ADCS-ADL MCI - Use Household Appliance: Microwave (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: Professional or Occupational Group described as occupational therapy assistants provide environmental modifications under the supervision of an occupational therapist. OTAs develop and implement an individualized occupational therapy environmental modification plan that reflects the relevant contexts of the client and relevant others and maximizes current and future occupational performance, safety, and participation of the client. Clients receive environmental modification recommendations and interventions that enable them to meet occupational performance and participation goals and that have adequate flexibility to accommodate for their future needs.\nConcepts: modulation by host of symbiont peptidase activity (modulation of peptidase activity in other organism involved in symbiotic interaction)\tBone Cancer pT0 TNM Finding v7 (Bone Cancer Pathologic Primary Tumor TNM Finding v7)\tTarget of Methylation-Induced Silencing 1 (Amino Acid, Peptide, or Protein)\tCULTURE MEDIA, ANTIFUNGAL, SUSCEPTIBILITY TEST (Medical Device)\t\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; Occupational Therapy Assistant, Environmental Modification (Professional or Occupational Group)", + "output": "\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; Occupational Therapy Assistant, Environmental Modification (Professional or Occupational Group)" + }, + { + "input": "Definition: Unit of Dose Calculation described as a unit of length equal to one millimeter that is used as a denominator to build a derived unit expressed as a ratio.\nConcepts: Dental Materials, Restorative, Amalgam (Dental Alloys)\tConcomitant Medication Use End Relative to Reference Period (End Relative to Reference Period)\tBuruli Ulcer (Skin and subcutaneous tissue ulcerations)\t/mm (Quantitative Concept)\tpositive regulation of G protein activated inward rectifier potassium channel activity (regulation of G-protein activated inward rectifier potassium channel activity)", + "output": "/mm (Quantitative Concept)" + }, + { + "input": "Definition: Muscle structure of pharynx described as a long, thin pharyngeal muscle, which originates on the styloid process with some fibers attaching to the constrictors and the lateral glossoepiglottic fold, while others attach to the thyroid cartilage; it functions to elevate the pharynx and larynx.\nConcepts: Nimustinum (Organic Chemical)\tStructure of stylopharyngeus muscle (Structure of half of neck lateral to midsagittal plane)\tBRAF V600 Wild Type (BRAF Gene Mutation Negative)\tActP (acetate transmembrane transporter activity)\tAutomatisms (Physical activity)", + "output": "Structure of stylopharyngeus muscle (Structure of half of neck lateral to midsagittal plane)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of pro-B cell differentiation.\nConcepts: substitute milk (Beverages)\tregulation of pro-B cell differentiation (Cell Function)\tPhage, Streptococcal (Bacteriophages)\tBreathing Effort Score (Apgar Score)\tbrainstem precerebellar neuron precursor migration (Cell Function)", + "output": "regulation of pro-B cell differentiation (Cell Function)" + }, + { + "input": "Definition: Synovial Fluid: Other Laboratory Findings described as WHAT: Synovial fluid\nConcepts: Synovial fluid mononuclear, % (Finding)\tMinimal distension/minimal duration; marked obstruction of flow (Finding)\tChronic gastritis, unspecified (Gastritis)\tSequences Total Score (Score)\tReactive Lymphocyte to Lymphocyte Ratio Measurement (Blood Cell Count Ratio Measurement)", + "output": "Synovial fluid mononuclear, % (Finding)" + }, + { + "input": "Definition: Governmental or Regulatory Activity described as a funding mechanism designed to ensure that new investigators share the same granting success rate as more established applicants.\nConcepts: Allopathic & Osteopathic Physicians; Psychiatry & Neurology, Diagnostic Neuroimaging (Professional or Occupational Group)\tIg heavy chain-bound ER chaperone complex location (Cell Component)\tSpecial Exceptions Process (Funding)\tCapillarities (Natural Phenomenon or Process)\tMyeloproliferative disease, NOS (Myeloproliferative disorders)", + "output": "Special Exceptions Process (Funding)" + }, + { + "input": "Definition: Sarcomatoid Mesothelioma described as malignant mesothelioma that arises from the pleura. It is characterized by the presence of spindle cells. Anaplastic morphologic features and multinucleated malignant cells may also be seen.\nConcepts: signs/symptoms-mental/emotional (Sign or Symptom)\tPleural Sarcomatoid Mesothelioma (Neoplastic Process)\tEC 1.1.1.105 (Oxidoreductase)\tColorectal Cancer pT4 TNM Finding v8 (Colorectal Cancer Pathologic Primary Tumor TNM Finding v8)\tGene Product Has Structural Domain Or Motif (Idea or Concept)", + "output": "Pleural Sarcomatoid Mesothelioma (Neoplastic Process)" + }, + { + "input": "Definition: Laboratory Procedure described as a bioassay used in the detection of interleukin-2 (IL-2) or interleukin-4 (IL-4) in the supernatants of in vitro-stimulated cells. It relies on the IL-2- or IL-4-dependence of a cytotoxic cell line (CTLL-2) for in vitro proliferation, and the measurement of the growth of the these cells is usually determined by tritiated-thymidine incorporation pulsed into the CTLL-2 culture 8-12 hours immediately prior to harvesting the CTLL-2 cells.\nConcepts: FAC062TC (Intellectual Product)\tCombined Oxidative Phosphorylation Deficiency 1 (Metabolic Diseases)\tInterleukin (IL)-2 assay (Cytokine assay)\tAcyl-Butyrolactone (Organic Chemical)\tCr (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "Interleukin (IL)-2 assay (Cytokine assay)" + }, + { + "input": "Definition: Congenital anomaly of brain described as a congenital abnormality characterized by a malformation of the head. The eyes are hypoteleric and the nose may be absent or misshapen (small, flattened, single nostril) and defective.\nConcepts: High Grade Squamous Intraepithelial Lesions (Squamous intraepithelial lesion)\tRelating with strangers (Particular interpersonal relationships)\tcebocephalus (Congenital anomaly of head)\tnegative regulation of type I interferon-mediated signaling pathway (negative regulation of innate immune response)\terythromycin topical cream (Anti-Infective Preparation)", + "output": "cebocephalus (Congenital anomaly of head)" + }, + { + "input": "Definition: Neoplastic Process described as stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0). T3: Tumor with direct invasion into any of the following: lung, brachiocephalic vein, superior vena cava, phrenic nerve, chest wall, or extrapericardial pulmonary artery or veins. T4: Tumor with invasion into any of the following: aorta (ascending, arch, or descending), arch vessels, intrapericardial pulmonary artery, myocardium, trachea, esophagus. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Stage III Thymus Epithelial Neoplasm (Neoplastic Process)\tThyroidinum / thyroid gland (Homeopathic remedies letter T)\tAbnormality of pulmonary circulation (Abnormal vascular physiology)\tnegative regulation of branch elongation involved in ureteric bud branching (negative regulation of developmental growth)\tMouth Partial Response GvHD (Partial Response in GvHD)", + "output": "Stage III Thymus Epithelial Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Enterobacteriaceae described as a genus of facultatively anaerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria and the family Enterobacteriaceae.\nConcepts: Muscle cramps with exertion (MUSCLE SOFT, TISSUE)\tSIAT7E (glycosyltransferase)\tThyroid Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)\tpositive regulation of vulval development (positive regulation of nematode larval development)\t163 MOELLERELLA (Moellerella)", + "output": "163 MOELLERELLA (Moellerella)" + }, + { + "input": "Definition: Amphotericin-containing product in parenteral dose form described as a liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B produced by the bacterium Streptomyces nodosus with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.\nConcepts: Mivavotinib (Protein-tyrosine kinase inhibitor)\tPartly Disagree (Finding)\tDAD01-Sub-Total Planning & Organization (Intellectual Product)\tAmphotericin B liposome product (phospholipids)\tTetracosapenta-9,12,15,18,21-enoic Acid (omega-3 fatty acids)", + "output": "Amphotericin B liposome product (phospholipids)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Elymus tricoides pollen antigen IgE antibody in a biological specimen.\nConcepts: ARGX-111 (Antineoplastic Antibody)\tElymus tricoides Pollen IgE Antibody Measurement (Laboratory Procedure)\tHDL Cholesterol/LDL Cholesterol (LDL Cholesterol Lipoproteins)\tInternet of Things (Internet)\tfamilies (Thesaurus of Psychological Index Terms)", + "output": "Elymus tricoides Pollen IgE Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) During the last week, has it been easy or hard for your child to: Climb three flights of stairs?\nConcepts: PODCI220 (Intellectual Product)\tcalbindin 2 (Ligand Binding Protein Gene)\tNFIA (Transcription factor genes)\tStool xenobiotic (Finding)\tpopulations (Quantitative Concept)", + "output": "PODCI220 (Intellectual Product)" + }, + { + "input": "Definition: something described as a question about whether an individual is or was limited by their ability to lift light objects because of their shoulder or neck.\nConcepts: Bermuda Grass Pollen IgG Measurement (Immunoglobulin measurement)\tHave you been limited in your ability to lift light objects because of your shoulder or neck (Intellectual Product)\tUnmasking (Blinded)\trhombomere 6 formation (rhombomere formation)\tNOT ASSIGNED (Finding)", + "output": "Have you been limited in your ability to lift light objects because of your shoulder or neck (Intellectual Product)" + }, + { + "input": "Definition: something described as extent of understanding conveyed about prevention of unintended pregnancy\nConcepts: Knowledge: Conception Prevention (Knowledge level: health promotion)\tDysphonia, NOS (voice functions)\tThyroid Gland Microfollicular Adenoma (Benign adenomatous neoplasm - category)\tregulation of 'de novo' NAD biosynthetic process from tryptophan (regulation of tryptophan metabolic process)\tcell proliferation involved in mesonephros development (Cell Function)", + "output": "Knowledge: Conception Prevention (Knowledge level: health promotion)" + }, + { + "input": "Definition: Urothelial cancer of renal pelvis described as renal pelvis urothelial carcinoma that has spread to another anatomical site.\nConcepts: BOF - Broncho-oesophag fistula (pathologic fistula)\tMetastatic Renal Pelvis Urothelial Cancer (Neoplastic Process)\tGastric Cancer pT1a TNM Finding v8 (Finding)\tCombined oxidative phosphorylation defect type 8 (Mitochondrial cytopathy)\tmol/L/(ug/kg) (Unit of concentration)", + "output": "Metastatic Renal Pelvis Urothelial Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as paced Tapping Test (Paced Tapping) Total number of intertap intervals within the self-paced tapping phase of Trial n, that were trimmed before analysis.\nConcepts: Respect and warmth in relationships (Social Behavior)\tPTAP114 (Paced Tapping Functional Test Question)\tnephron morphogenesis (Organ or Tissue Function)\tregulation of blood coagulation (regulation of hemostasis)\tcell plate formation involved in plant-type cell wall biogenesis (mitotic cell cycle process)", + "output": "PTAP114 (Paced Tapping Functional Test Question)" + }, + { + "input": "Definition: Minerals described as a metallic element with the atomic symbol V, atomic number 23, and atomic weight 50.94. It is used in the manufacture of vanadium steel. Prolonged exposure can lead to chronic intoxication caused by absorption usually via the lungs.\nConcepts: Patient cue monitoring each 15 minutes (Psychosocial intervention strategy)\tVANADIUM (Vanadium and vanadium compound)\tMAP1LC3A gene (Genes, Regulator)\tcope (Nursing Diagnoses)\tBARS, PARALLEL, POWERED (Medical Device)", + "output": "VANADIUM (Vanadium and vanadium compound)" + }, + { + "input": "Definition: something described as ultrasound therapy systems that deliver energy into the vessels to eliminate areas of narrowing (i.e., angioplasty). These systems include a radio-frequency generator (frequency of 20 kHz is typical), ultrasonic transducers, and a catheter. Some systems include a ball-tipped wire that act as an acoustic wave guide, transmitting the energy to the target areas within the artery; other systems use small ultrasonic transducers on the distal tip of a catheter that are excited to produce the ultrasonic waves. Ultrasound angioplasty systems are mostly used in total occlusion and calcified plaques and to facilitate balloon angioplasty.\nConcepts: Beta-TG (Biologically Active Substance)\telectronic pacemaker (Heart, Artificial)\tUltrasound Therapy Systems, Angioplasty (Ultrasound Therapy Systems)\t2 cyclooxygenase (Enzyme)\tType 1 Hypersensitivity Reaction (Immune System Diseases)", + "output": "Ultrasound Therapy Systems, Angioplasty (Ultrasound Therapy Systems)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order.\nConcepts: Social worker (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tViral Replicase Complex Proteins (Viral Nonstructural Proteins)\tMedulloblastoma NOS (Primary malignant neoplasm)\tComparative Genomic Hybridization (CGH) Microarrays (Medical Device)\trhombomere 4 development (Organ or Tissue Function)", + "output": "rhombomere 4 development (Organ or Tissue Function)" + }, + { + "input": "Definition: Enzyme described as ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (875 aa, ~100 kDa) is encoded by the human ENPP3 gene. This protein plays a role in the cleavage of phosphodiester and phosphosulfate bonds.\nConcepts: positive regulation of cell cycle process (Cell Function)\tENPP3 protein, human (Amino Acid, Peptide, or Protein)\tZinc Finger, GATA-Like Protein 1 Gene (Gene or Genome)\tMesembryanthemum (Plant)\tmammary gland lobule development (Organ or Tissue Function)", + "output": "ENPP3 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: GAIA Obstetric Case Definitions described as a classification of maternal and fetal outcomes relating to spontaneous abortion and ectopic pregnancy, developed by the Global Alignment of Immunization safety Assessment in pregnancy, based on the extent to which the diagnosis has been confirmed.\nConcepts: Propicillin (penicillins)\tCD9 antigen (p24) protein, human (Cell Adhesion Molecules)\tP450 CYP2C19 Inhibitors (Pharmacologic Substance)\tGAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty (Intellectual Product)\tZidapamide (Pharmacologic Substance)", + "output": "GAIA Spontaneous Abortion and Ectopic Pregnancy Level of Diagnostic Certainty (Intellectual Product)" + }, + { + "input": "Definition: Finding described as choroidal and ciliary body melanoma, any tumor size category with extraocular extension more than 5 mm in largest diameter.\nConcepts: SN Term Type (Term Type)\tUnopened tear duct (Disorder of nasolacrimal duct)\t1,2-dihydroxy-phenanthrene glycosyltransferase activity (phenol beta-glucosyltransferase activity)\tAnal Cancer by AJCC v8 Stage (Anal carcinoma)\tChoroidal and Ciliary Body Melanoma pT4e TNM Finding v8 (Finding)", + "output": "Choroidal and Ciliary Body Melanoma pT4e TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as a cortical structure located on the lateral surface of the cerebral hemisphere at the junction of the occipital lobe and temporal lobe, between early visual cortex and the MT+ complex of the human. Defined by multiple criteria, it is a part of MT+ neighbors. Compared to adjacent areas, it is fMRI activated in a TOOL task, a RELATIONAL-MATCH contrast, WORKING MEMORY, RELATIONAL, EMOTION, and PLACE tasks. It is less activated in a BODY task and is variably activated or deactivated, depending on the comparison area, in a FACES-SHAPES contrast. Other authors have referred to the same topological area as V3A,V3B, or hOC4la ( Glasser-2016 ).\nConcepts: CDISC Protocol Oversight Entity Value Set Terminology (Intellectual Product)\tSTILBIND (Intellectual Product)\tarea V3CD (Body Location or Region)\tAnalyzers, Laboratory, Blood, Urea Nitrogen (Analyzers, Laboratory, Blood)\tJ/kgK (Unit of Specific Entropy)", + "output": "area V3CD (Body Location or Region)" + }, + { + "input": "Definition: Molecular Function described as a photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II.\nConcepts: CDRS-R - Social Withdrawal (CDRS-R Clinical Classification Question)\tnoncyclic photosynthetic phosphorylation (Molecular Function)\tBronchial Constriction (Respiratory process)\tspleen trabecula formation (trabecula formation)\tresponse to sterol (Cell Function)", + "output": "noncyclic photosynthetic phosphorylation (Molecular Function)" + }, + { + "input": "Definition: Antifungal Agents described as a synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections.\nConcepts: allogeneic mesothelioma tumor lysate-pulsed autologous DC vaccine (Cell)\tCa(OH) - Calcium hydroxide (Calcium Compounds)\t(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one (Antifungal Agents)\tetidronate-cytarabine conjugate MBC-11 (Antineoplastic Agents)\tfluorine F 18 galacto-RGD peptide (Indicator, Reagent, or Diagnostic Aid)", + "output": "(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one (Antifungal Agents)" + }, + { + "input": "Definition: Intellectual Product described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Physical assault (for example, being attacked, hit, slapped, kicked, beaten up): Doesn't apply.\nConcepts: ELISA/ACT(R) Screening Mold Block 28 each test (Laboratory Procedure)\tNail Discoloration, CTCAE (Finding)\tLEC-5 Standard Version - Physical Assault: Not Apply (LEC-5 Standard Version Questionnaire Question)\tStage IV Nasopharyngeal Throat Cancer (Neoplastic Process)\trecurrent nasopharyngeal cancer (stage, nasopharyngeal cancer)", + "output": "LEC-5 Standard Version - Physical Assault: Not Apply (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Osteopathic manipulation described as a term used to describe the impact of intrathoracic pressure changes on lymphatic flow. This was the name originally given to the thoracic pump technique before the more extensive physiologic effects of the technique were recognised.\nConcepts: UHDRS 1999 Version - UDHR1-Delusions: Severity (UHDRS 1999 Version Clinical Classification Question)\tLymphatic pump (Osteopathic manipulation)\tviral DNA genome packaging, headful (viral DNA genome packaging)\tSelf-Application Tourniquets (Medical Device)\tCENP-T-W-S-X complex location (Cell Component)", + "output": "Lymphatic pump (Osteopathic manipulation)" + }, + { + "input": "Definition: something described as a country in Southern Europe, occupying a peninsula extending into the central Mediterranean Sea, northeast of Tunisia.\nConcepts: Abnormality of the forehead soft spot (Anatomical Abnormality)\tRetinoid Binding Protein (vitamin receptor)\tInfection, Intraabdominal (Disease or Syndrome)\tcity (Geographic Area)\titaly (Europe)", + "output": "italy (Europe)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of organic cyclic compound.\nConcepts: Vertebral cementoplasty (Orthopedic Surgical Procedures)\tTendinous sheath of extensor digitorum and extensor indicis (Wrist)\torganic cyclic compound biosynthesis (organic substance biosynthetic process)\tHartmannella species (Eukaryote)\tSubstance Use Start Date Time (Temporal Concept)", + "output": "organic cyclic compound biosynthesis (organic substance biosynthetic process)" + }, + { + "input": "Definition: something described as psoriasis Area and Severity Index (PASI) Trunk (T): Infiltration (I).\nConcepts: Exsanguinating Hemorrhages (Death)\tSwine Vesicular Disease Virus (Virus)\tAntagonists, Protein Synthesis (Protein, Organized by Function)\tatorvastatina (Azoles)\tPASI0109 (Intellectual Product)", + "output": "PASI0109 (Intellectual Product)" + }, + { + "input": "Definition: cell fate commitment described as the process in which a lymphoid progenitor cell becomes committed to become any type of B cell.\nConcepts: B cell lineage commitment (Cell Function)\tintermediate division of the basal nucleus (Body Part, Organ, or Organ Component)\tBase R CZ (Structure of right half of prostate)\tPancreatic Intraductal Papillary-Mucinous Tumor (Pancreatic Intraductal Neoplasms)\tGrade 4 Cecal Hemorrhage, CTCAE (Cecal Hemorrhage, CTCAE)", + "output": "B cell lineage commitment (Cell Function)" + }, + { + "input": "Definition: something described as any deviation from the normal concentration of glutamine-family amino acids in the cerebrospinal fluid.\nConcepts: F11R wt Allele (F11R gene)\tGlyprothiazol (Pharmacologic Substance)\tGuillotines, Rib (Device associated with blades)\tAbnormal CSF glutamine family amino acid concentration (Abnormal CSF amino acid concentration)\tWPAI-GH Version 2 - Activity Impairment Score (Intellectual Product)", + "output": "Abnormal CSF glutamine family amino acid concentration (Abnormal CSF amino acid concentration)" + }, + { + "input": "Definition: Pharmacologic Substance described as a cancer vacine containing four HLA-A*2402-restricted peptide epitopes with potential immunostimulatory and antitumor activities. Peptide epitopes in this vaccine are derived from: URLC10 (up-regulated lung cancer 10), TTK (TTK protein kinase), and VEGFRs (vascular endothelial growth factor receptors) 1 and 2. Upon administration, URLC10-TTK-KOC1-VEGFR1-VEGFR2 multipeptide vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells expressing URLC10, TTK, VEGFR 1 and 2 peptides, resulting in cell lysis and decreased tumor growth. HLA-A*2402 is an MHC class I molecule that presents antigenic peptides to CD8+ T cells; epitope design restricted to epitopes that bind most efficiently to HLA-A*2402 may improve antigenic peptide immunogenicity.\nConcepts: Cocrystallography (Crystallography)\tBoykin Spaniel (Sporting Breed)\tComplete duplication of the middle phalanx of the 2nd finger (Duplication of the middle phalanx of the 2nd finger)\tBahamian (Black Caribbean)\tHLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine (Vaccines, Peptide)", + "output": "HLA-A*2402-Restricted URLC10-TTK-VEGFR1-VEGFR2 Multipeptide Vaccine (Vaccines, Peptide)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Description of non-specific active suicidal thoughts.\nConcepts: Missed Indicator (Indicator)\tC-SSRS Children's Baseline/Screening - Description of Non-Specific Active Suicidal Thoughts (C-SSRS Children's Baseline/Screening Questionnaire Question)\tPQL03-Money Problem in Our Family (Intellectual Product)\tGrade 4 Neonatal Gastrointestinal Bleeding, Adverse Event (Neonatal Gastrointestinal Bleeding, AE)\tMelanoma of the Conjunctiva TNM Finding v7 (Finding)", + "output": "C-SSRS Children's Baseline/Screening - Description of Non-Specific Active Suicidal Thoughts (C-SSRS Children's Baseline/Screening Questionnaire Question)" + }, + { + "input": "Definition: Brain Diseases, Metabolic, Inborn described as a rare and severe disorder of urea cycle metabolism most commonly characterised by either a neonatal-onset of severe hyperammonaemia that occurs few days after birth and manifests with lethargy, vomiting, hypothermia, seizures, coma and death or a presentation outside the newborn period at any age with (sometimes) milder symptoms of hyperammonaemia. The disease is due to mutations in the CPS1 gene (2p) that encodes carbamoyl-phosphate synthetase I (CPS1), an enzyme located in the mitochondrial matrix of hepatocytes and epithelial cells of intestinal mucosa that controls the first step of the urea cycle where ammonia is converted into carbamoyl-phosphate. Mutations in this gene lead to an interruption in the urea cycle and excess nitrogen is not converted to urea for excretion by the kidneys, leading to hyperammonemia. Inherited in an autosomal recessive manner.\nConcepts: Stage IV Ampulla of Vater Cancer (Ampulla of Vater Cancer by AJCC v8 Stage)\tCarbamoyl Phosphate Synthetase I Deficiency Disease (Urea Cycle Disorders, Inborn)\tGastroenteritis-related afebrile seizure (Disease or Syndrome)\tComparative Brain Tumor Consortium (Component of the Center for Cancer Research)\tsolid (General adjectival modifier)", + "output": "Carbamoyl Phosphate Synthetase I Deficiency Disease (Urea Cycle Disorders, Inborn)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder characterised by persistent eosinophilia and acute endocardial lesions, which may progress to endomyocardial fibrosis; most cases are idopathic, but there is some association with malignant tumors.\nConcepts: EXTRA-AMNIOTIC (RouteBySite)\tFACILITY CONTACT (contact person)\t11: 62097927-62083649 (Chromosome 11 Physical Location)\tconstrictive endocarditis (Non-Neoplastic Heart Disorder)\tMeasurement of ribosomal P protein antibody (Antibody measurement)", + "output": "constrictive endocarditis (Non-Neoplastic Heart Disorder)" + }, + { + "input": "Definition: something described as a ligase that catalyzes the first step in the ubiquitination reaction via the ligation of the C-terminal lysine of ubiquitin to the E1 enzyme in an ATP-dependent reaction.\nConcepts: Germinoblastic sarc, follicul (Aggressive Non-Hodgkin Lymphoma)\tubiquitin activating enzyme (Ubiquitin-Protein Ligase Complexes)\tSFMP205 (Short-Form MPQ-2 Questionnaire Question)\tFerguson angle (Body Location or Region)\tserpins (Protein Family)", + "output": "ubiquitin activating enzyme (Ubiquitin-Protein Ligase Complexes)" + }, + { + "input": "Definition: Regimen Used to Treat Myelodysplastic Syndromes described as a regimen consisting of rabbit anti-thymocyte globulin, prednisone and tacrolimus that can be used in the treatment of myelodysplastic syndrome (MDS) and the prevention and treatment of graft rejection.\nConcepts: Health Technologists and Technicians (Miscellaneous Occupation)\tLeporine ATG/Prednisone/Tacrolimus Regimen (Therapeutic or Preventive Procedure)\tQuality of Work Life (Perceived quality of life)\tHealth System (Governmental or Regulatory Activity)\tTNFR1 Signaling Pathway (Cell Function)", + "output": "Leporine ATG/Prednisone/Tacrolimus Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a densely packed group of neurons dorsal to the inferior cerebellar peduncle that project to the oculomotor nuclear complex via the medial longitudinal fasciculus ( Carpenter-1983 ).\nConcepts: ciprofloxacin (Pharmacologic Substance)\tDissolvable Microneedle Array (Medical Device)\tB2 PINEAL BODY (Entire endocrine gland)\tMIRN510 (MIR510 gene)\tcell group y (Subdivision of inferior vestibular nucleus)", + "output": "cell group y (Subdivision of inferior vestibular nucleus)" + }, + { + "input": "Definition: Subgingival Curettage described as a procedure for smoothing of the roughened root surface or cementum of a tooth after subgingival curettage or scaling, as part of periodontal therapy.\nConcepts: Paracardial gastric lymph node (Lymph node of stomach)\tHyperinsulinism in the Infant of a Diabetic Mother (Disease or Syndrome)\tZ-band streaming (Finding)\tMedication-Taking Patient (Patient or Disabled Group)\tRP - Root planing of tooth (Dental Scaling)", + "output": "RP - Root planing of tooth (Dental Scaling)" + }, + { + "input": "Definition: something described as catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose.\nConcepts: Ethers, Methylphenyl (Methyl Ethers)\tcineangiography (angiogram)\tlactose synthase activity (UDP-galactosyltransferase activity)\t2(1H)-Pyrimidinone, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-iodo- (pyrimidine analog)\tPerformed Activity Order Care Setting Type Code (Order Care Setting Type Code)", + "output": "lactose synthase activity (UDP-galactosyltransferase activity)" + }, + { + "input": "Definition: DNA repair protein described as double-strand-break repair protein rad21 homolog (631 aa, ~72 kDa) is encoded by the human RAD21 gene. This protein is involved in DNA repair, cell cycle-dependent chromosomal cohesion and apoptosis.\nConcepts: Absent patellar reflexes (Peripheral Nervous System)\tEruptive Collagenoma (Collagen nevus of skin)\tSuntanning (Daily or Recreational Activity)\thHR21 (Amino Acid, Peptide, or Protein)\tCVAD Regimen (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "hHR21 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a procedure in which the catheter is passed into a peripheral vessel (usually in the groin) for the purpose of angiography of the abdomen, hands, arms, feet and legs.\nConcepts: angiograms peripheral (angiogram)\t3-Nitrobenzo[a]pyrene (Hazardous or Poisonous Substance)\tmRNA splicing, via endonucleolytic cleavage and ligation (Genetic Function)\t12p13.3 (Cell Component)\tMicroRNA 375 wt Allele (Gene or Genome)", + "output": "angiograms peripheral (angiogram)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of cytarabine and idarubicin used as both an induction and consolidation (post remission) treatment for acute myeloid leukemia.\nConcepts: TLR-directed cationic lipid-DNA complex JVRS-100 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tAdenolipoma (Neoplastic Process)\tCytarabine-Idarubicin Regimen (Regimen Used to Treat Acute Myeloid Leukemia)\tregulation of attachment of spindle microtubules to kinetochore involved in meiosis I (regulation of homologous chromosome segregation)\tossicular chain (Irregular bone)", + "output": "Cytarabine-Idarubicin Regimen (Regimen Used to Treat Acute Myeloid Leukemia)" + }, + { + "input": "Definition: mRNA Transport Gene described as this gene may be involved in the regulation of mRNA trafficking.\nConcepts: Autologous CART-19:TCR Cells (Antineoplastic Immune Cell)\tFAC057-Numbness or Tingling in My Feet (Intellectual Product)\tVAV Family Gene (Gene or Genome)\tMGC87458 (Gene or Genome)\tCalculated Left Ventricular Ejection Fraction (Diagnostic Procedure)", + "output": "MGC87458 (Gene or Genome)" + }, + { + "input": "Definition: Examination of penis described as the rounded, gland-like head of the penis.\nConcepts: Cancer Cluster (Hot Spots)\tGrade 4 Infective myositis (Finding)\tPENIS, GLANS (Zone of corpus spongiosum of penis)\t{CAN} (Unit dose)\tPDGFRalpha Mutation Analysis (Genetic Variation Analysis)", + "output": "PENIS, GLANS (Zone of corpus spongiosum of penis)" + }, + { + "input": "Definition: Protective Agents described as a proprietary formulation comprised of the serine protease inhibitor tranexamic acid (TXA), polyethylene glycol (PEG), electrolytes, and sugar, with potential GI protective activity. After reconstitution in water and upon oral or enteral administration before abdominal surgery, TXA in the protease inhibitor formulation LB1148 targets and inhibits several serine proteases in the gastrointestinal (GI) tract, thereby preventing and protecting the intestinal mucosa against degradation, which preserves gastrointestinal (GI) integrity, function and motility. By inhibiting digestive proteases, the intestinal mucosal barrier is preserved during acute physiologic shock, which may prevent multi-organ failure, postoperative ileus and surgical intra-abdominal adhesions. PEG enhances transport of TXA through the GI tract. The other components provide energy and balance dietary electrolytes, thereby promoting healing of the GI barrier.\nConcepts: Superfamily strongyloidea (Strongylida)\tPQL04-Hard Ask Doctors/Nurses Questions (Intellectual Product)\tCDISC Clinical Classification BDI Test Name Terminology (CDISC Clinical Classification Terminology)\tGILLES DE LA TOURETTE DIS (Congenital and hereditary neurological disorders NEC)\tProtease Inhibitor Formulation LB1148 (Organic Chemical)", + "output": "Protease Inhibitor Formulation LB1148 (Organic Chemical)" + }, + { + "input": "Definition: CDISC Functional Test Terminology described as nine-Hole Peg Test test code.\nConcepts: Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Gene (Adaptor Signaling Protein Gene)\tUrinary tract infection (Urinary tract infection)\tNine-Hole Peg Test Functional Test Test Code (Intellectual Product)\tCRF Completn Reqrt (Intellectual Product)\tsarcoma of tongue (sarcoma of oral cavity)", + "output": "Nine-Hole Peg Test Functional Test Test Code (Intellectual Product)" + }, + { + "input": "Definition: something described as the growth and division of pre-existing MITOCHONDRIA.\nConcepts: bifidum; sternum (Congenital Abnormality)\tStage III Soft Tissue Sarcoma of the Trunk and Extremities (Neoplastic Process)\tVena Cava Clips, Implantable (Clips, Implantable, Vascular)\tPlumeria L., 1753 (Plumeriinae)\tMitochondrial Biogenesis (Cell Function)", + "output": "Mitochondrial Biogenesis (Cell Function)" + }, + { + "input": "Definition: Brain Concussion described as the organic and psychogenic disturbances observed after closed head injuries (HEAD INJURIES, CLOSED). Post-concussion syndrome includes subjective physical complaints (i.e. headache, dizziness), cognitive, emotional, and behavioral changes. These disturbances can be chronic, permanent, or late emerging.\nConcepts: History of Medicine, Modern (Temporal Concept)\tdietary constituent (Substance)\tpost concussional syndrome (Brain Concussion)\tUterine Carcinosarcoma, Homologous Type (Uterine Carcinosarcoma)\tDRRI-2 - N: Unwanted Sexual Activity (DRRI-2 Questionnaire Question)", + "output": "post concussional syndrome (Brain Concussion)" + }, + { + "input": "Definition: Actinobacteria class described as a genus of high GC content gram positive bacteria of the family Pseudonocardiaceae in the order Pseudonocardiales. It is known for producing the antibiotics epoxyquinomycin, VANCOMYCIN, and RISTOCETIN which are used in treating various infections.\nConcepts: CCAAT-binding factor complex location (Cell Component)\tLasers, Ho:YAG, Angioplasty (Holmium:YAG laser device)\tLiving Arrangement (Idea or Concept)\tAd-hCMV-TK (Gene Therapy Agent)\tAmycolatopsis Lechevalier et al. 1986 emend. Tang et al. 2010 (unclassified Amycolatopsis)", + "output": "Amycolatopsis Lechevalier et al. 1986 emend. Tang et al. 2010 (unclassified Amycolatopsis)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate.\nConcepts: Renal Fanconi Syndrome (Disease or Syndrome)\tROP stage 3 (Retinopathy of Prematurity)\tgeranylgeranyl-diphosphate synthase activity (Molecular Function)\tcellular response to diosgenin (response to diosgenin)\tgeraniol catabolic process (primary alcohol catabolic process)", + "output": "geranylgeranyl-diphosphate synthase activity (Molecular Function)" + }, + { + "input": "Definition: detection of mechanical stimulus involved in sensory perception described as the series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal.\nConcepts: Mild Dementia or Depression (Finding)\t-phosphatase (Protein phosphatase)\tBlood Cancer-Derived Blood Sample, Post-Treatment (whole blood specimen)\tsensory transduction of sound (detection of mechanical stimulus involved in sensory perception)\tAnti-Fogging Solution/Gels (Device Labeled for Single Use)", + "output": "sensory transduction of sound (detection of mechanical stimulus involved in sensory perception)" + }, + { + "input": "Definition: Embryonic venous structure described as the veins occurring during embryonic development that drain the yolk sack.\nConcepts: Abnormality of the facial nerve (Abnormality of the cranial nerves)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Leishmania Species (Medical Device)\tVitelline Vein (Embryonic Structures)\tlarge-cell neuroendocrine carcinoma (Neuroendocrine Tumors)\tSurgery, Revision (Non-site specific procedural complications)", + "output": "Vitelline Vein (Embryonic Structures)" + }, + { + "input": "Definition: Anthracyclines described as tricyclic pentaglycosidic antibiotic from Streptomyces strains that inhibits RNA and protein synthesis by adhering to DNA; used as a fluorescent dye and as an antineoplastic agent, especially in bone and testicular tumors; also used to reduce hypercalcemia, especially that due to malignancies.\nConcepts: Nitric Oxide Synthase, Type I (Enzyme)\tsecondary cell wall (plant-type cell wall)\tEmbolic and thrombotic events, vessel type unspecified and mixed arterial and venous (Classification)\tCOVAL (Quantitative Concept)\tProduct containing plicamycin (Antineoplastic Agents)", + "output": "Product containing plicamycin (Antineoplastic Agents)" + }, + { + "input": "Definition: something described as the lipid bilayer surrounding the host cell endoplasmic reticulum.\nConcepts: Benzofuran (furan)\tLithium - Induced Nephropathy (Drug-induced Nephropathy)\tGluten-free diet (Food allergy diet)\thost cell endoplasmic reticulum membrane (Cell Component)\tcellular response to cadmium ion (response to cadmium ion)", + "output": "host cell endoplasmic reticulum membrane (Cell Component)" + }, + { + "input": "Definition: Health Services described as care given to patients by nursing service personnel.\nConcepts: Hyperinsulinism due to UCP2 deficiency (Hereditary disorder of endocrine system)\tNURS CARE (Care given by nurses)\tArachidonate:oxygen 12-oxidoreductase (Oxidoreductase)\tLysosomal-Associated Transmembrane Protein 4B (Regulatory Protein)\tPostprandial hyperglycaemia (Hyperglycemia)", + "output": "NURS CARE (Care given by nurses)" + }, + { + "input": "Definition: Level of stress described as abnormal frequency and fluidity of feces\nConcepts: amino acid fermentation (nitrogenous compound fermentation)\tAminoxafen (Organic Chemical)\tDiarrhoea (Chemotherapy: Disruptive Physical Effects)\teye refractometry (Vision Tests)\truvalcaba-myhre syndrome (Musculoskeletal and connective tissue disorders of skull congenital)", + "output": "Diarrhoea (Chemotherapy: Disruptive Physical Effects)" + }, + { + "input": "Definition: Diagnostic Equipment, Ophthalmological described as ophthalmic measuring instruments designed to determine the anomalies of color vision by assessing how the patient matches yellow light with a mixture of green and red light. The devices consist of a system of light sources, a lens, prisms, slit mechanism, eyepieces, and controls with scales for adjusting the intensity and wavelength of the lights; some have a digital display for light parameter values. A patient observes the field in the eye-piece, half of which presents a yellow light and half of which presents a mixing of red and green light, and matches the two half fields by adjusting the brightness of the yellow light and/or the proportion of the red/green mixture. Anomaloscopes are used mainly for the assessment of color vision and the detection of color vision deficiency.\nConcepts: stretch reflex (Organ or Tissue Function)\tMesothelioma malignant localised (stage, malignant mesothelioma)\tCryoglobulinemia (Abnormality of humoral immunity)\tAnomaloscope (Diagnostic Equipment, Ophthalmological)\tIntracranial Artery Stents (Vascular stent)", + "output": "Anomaloscope (Diagnostic Equipment, Ophthalmological)" + }, + { + "input": "Definition: Functional Concept described as in medicine, having to do with the movement of body parts.\nConcepts: Certified registered nurse anaesthetist (Advanced Practice Nurse)\tTesticular Mixed Germ Cell-Sex Cord-Stromal Neoplasm (Testicular Neoplasms)\tAcquiring skills of numeracy such as counting and ordering (Mental Process)\tRabdosia (Lamiaceae)\tmotor (Anatomy Qualifier)", + "output": "motor (Anatomy Qualifier)" + }, + { + "input": "Definition: something described as twenty-two species of new world monkeys in the genera Callithrix, Cebuella, Callibella, and Mico.\nConcepts: Marmoset (Cebidae)\tStudy Subject Digital Photograph (photograph)\tForty (Natural Number)\tMonocytes and Macrophages to Leukocytes Ratio Measurement (Laboratory Procedure)\tGrade 5 Neonatal Tachyarrhythmia, Adverse Event (Finding)", + "output": "Marmoset (Cebidae)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.\nConcepts: Wound is consistent with the stages of wound healing or improved from baseline levels (Physiologic Responses)\tnicotinamide nucleotide biosynthetic process (Molecular Function)\tSGRQ Past 3 Months Version - Wheeze Worse When Get Up in the Morning (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tL-Gossypol (Protein Kinase C Inhibitor)\tprimary charge separation in photosystem I (Molecular Function)", + "output": "nicotinamide nucleotide biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as an instrument for evaluation of social functioning in individuals from preschool to 18 years old. Focusing on adaptive behaviors, the results are meant to support the diagnosis of intellectual and developmental disabilities.\nConcepts: VABS (Intellectual Product)\tDevice Observer Physical Location During Observation (Location)\tImmunologic Factor Suppression (Immunologic Factor Process)\tRETPT (Intellectual Product)\tReproductive and Developmental Toxicity: Prenatal and Postnatal Development Including Maternal Function (Regulation or Law)", + "output": "VABS (Intellectual Product)" + }, + { + "input": "Definition: Stage II Non-Contiguous Adult Indolent Non-Hodgkin Lymphoma described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3).\nConcepts: vegetarian diet (Diet therapy)\tpositive regulation of DDX58 signaling pathway (regulation of RIG-I signaling pathway)\tStage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma (Stage II Adult Diffuse Small Cleaved Cell Lymphoma)\tAntramycin (DNA Minor Groove Binding Agent)\t6: 336760-3356193 (Chromosome 6 Physical Location)", + "output": "Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma (Stage II Adult Diffuse Small Cleaved Cell Lymphoma)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in ubiquitin-dependent proteolysis.\nConcepts: radiology pacs (Document Management System)\tUBC (Gene or Genome)\tIgE receptor activity (immunoglobulin receptor activity)\tRisk for complicated grieving (Finding)\tLiver Cell Carcinoma pN0 TNM Finding v8 (Hepatocellular Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "UBC (Gene or Genome)" + }, + { + "input": "Definition: something described as a fusion protein that is encoded by the RBM15/MKL1 fusion gene. This protein consists of most of the putative RNA-binding protein 15, including the RNA recognition motifs and the SPOC domain, fused to most of the MKL/myocardin-like protein 1, including the scaffold attachment factor box.\nConcepts: Congenital sacral meningocoele with conotruncal heart defect syndrome (Congenital anomaly of skeletal bone)\tFIQR01-Your Sleep (FIQR Questionnaire Question)\tRBM15/MRTFA Fusion Protein (Amino Acid, Peptide, or Protein)\tGIG3 (FADD gene)\tFocal aware clonic seizure (Focal motor aware seizure)", + "output": "RBM15/MRTFA Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Since Last Visit - Have you had these thoughts and had some intention of acting on them?\nConcepts: mandelate anabolism (mandelate metabolic process)\tIntrahepatic (Functional Concept)\tC-SSRS Since Last Visit - Ideation With Intent, No Plan (C-SSRS Since Last Visit Questionnaire Question)\tmesonephric glomerular parietal epithelial cell differentiation (mesonephric glomerular epithelial cell differentiation)\tmyoblast migration (Cell Function)", + "output": "C-SSRS Since Last Visit - Ideation With Intent, No Plan (C-SSRS Since Last Visit Questionnaire Question)" + }, + { + "input": "Definition: Autonomic nervous system described as disorders of the AUTONOMIC NERVOUS SYSTEM occurring as a primary condition. Manifestations can involve any or all body systems but commonly affect the BLOOD PRESSURE and HEART RATE.\nConcepts: peroxisome matrix protein import, docking (Cell Function)\tobsolete Dysautonomia (Non-Neoplastic Peripheral Nervous System Disorder)\tstannum metallicum/tin (Elements, Ions and Simple Compounds)\tLoans, Interlibrary (Library Services)\tsocioeconomic factor (Group Attribute)", + "output": "obsolete Dysautonomia (Non-Neoplastic Peripheral Nervous System Disorder)" + }, + { + "input": "Definition: Intellectual Product described as psoriasis Area and Severity Index - Upper Extremities (U): Desquamation (D).\nConcepts: Feeling more or less hungry than you usually do (Clinical or Research Assessment Question)\tHBGF 02 (Amino Acid, Peptide, or Protein)\tPASI - Upper Extremities (U): Desquamation (PASI Clinical Classification Question)\tGrade 4 Neonatal Diarrhea, Adverse Event (Neonatal Diarrhea, Adverse Event)\tProgressive encephalopathy with edema, hypsarrhythmia, and optic atrophy-like syndrome (Hereditary disorder of nervous system)", + "output": "PASI - Upper Extremities (U): Desquamation (PASI Clinical Classification Question)" + }, + { + "input": "Definition: BCOR Gene Mutation described as a genetic abnormality that arises from tandem duplications of the exon encoding the C-terminus of the BCL-6 corepressor (BCOR) protein, which results in constitutive activation of BCOR protein and its downstream signaling pathways.\nConcepts: Transplant-Related Bladder Urothelial Carcinoma (Neoplastic Process)\tProduct containing selenium sulfide (Topical anti-infective)\tMCOPS2 Final Exon Internal Tandem Duplication (Cell or Molecular Dysfunction)\tBerry-Kravis and Israel syndrome (Disease or Syndrome)\tPolus superior testis (Body Part, Organ, or Organ Component)", + "output": "MCOPS2 Final Exon Internal Tandem Duplication (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: ADCS-ADL MCI Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) Regarding physically getting dressed, which best describes his or her usual performance in the past 4 weeks.\nConcepts: Tumor Necrosis Factor alpha (Protein or Enzyme Type Measurement)\tReduced lymphocyte surface expression of sialophorin (Finding)\tADL03-Usual Physically Dressing Perform (Intellectual Product)\t(1H)-3-hydroxy-4-oxoquinoline 2,4-dioxygenase activity (Molecular Function)\tCD40 receptor binding (tumor necrosis factor receptor superfamily binding)", + "output": "ADL03-Usual Physically Dressing Perform (Intellectual Product)" + }, + { + "input": "Definition: Analog described as synthetic or natural compounds which resemble naturally occurring amino acids in structure and/or function.\nConcepts: dipeptidylpeptidase 9 (Gene or Genome)\taminoacid analog (Amino Acid, Peptide, or Protein)\tSTRONTIUM BROMIDE homeopathic preparation (Pharmacologic Substance)\tADCIP01 (ADAS-Cog CDISC Version Questionnaire Question)\tMajor cosmetic (Intellectual Product)", + "output": "aminoacid analog (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a carcinoma that arises from the oral cavity and has metastasized to another anatomic site.\nConcepts: microgram per meter squared (Mass per unit area)\tDefined Substance Administration Product Dose (Product Dose)\tCCL26 gene (CC Cytokine Gene)\tSections, Frozen (Cryoultramicrotomy)\tMetastatic Oral Cavity Carcinoma (Metastatic Lip and Oral Cavity Carcinoma)", + "output": "Metastatic Oral Cavity Carcinoma (Metastatic Lip and Oral Cavity Carcinoma)" + }, + { + "input": "Definition: Attenuated Bacteria Vaccine described as an oral rinse solution containing a strain of the bacteria Lactococcus lactis (L. lactis) genetically modified to express human Trefoil Factor 1 (hTFF1) with potential cytoprotective activity. With oral rinsing, human trefoil factor 1-secreting Lactococcus lactis AG013 may secrete and deliver hTFF1 to oral mucosal tissue, protecting or promoting the healing of damaged oral mucosa. hTFF1, a peptide belonging to the Trefoil factors family (TFF), is normally secreted by mucous epithelia and is involved in protecting mucosal tissue and maintaining mucosal surface integrity.\nConcepts: Stage IIA Vaginal Cancer (Neoplastic Process)\tregulation of cell wall chitin formation (regulation of cellular component biogenesis)\thTFF1-Secreting Lactococcus lactis AG013 (Pharmacologic Substance)\tRNA, Transfer, Gly (Nucleic Acid, Nucleoside, or Nucleotide)\tCompounds, Silicon (Inorganic Chemical)", + "output": "hTFF1-Secreting Lactococcus lactis AG013 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a subtype of endothelin receptor found predominantly in the KIDNEY. It may play a role in reducing systemic ENDOTHELIN levels.\nConcepts: up-regulation of phosphatidylinositol 3-kinase activity (positive regulation of lipid kinase activity)\tEndothelin Receptor Non-Selective Type (Receptor)\tcentipoise (Quantitative Concept)\tVaccineEntityType (Pharmaceutical Preparations)\tGenus Calymmatobacterium (Enterobacteriaceae)", + "output": "Endothelin Receptor Non-Selective Type (Receptor)" + }, + { + "input": "Definition: Geographic Area described as a civilization of ancient Northeastern Africa, concentrated along the lower reaches of the Nile River in the area of Egypt. It was active from 3100 B.C. until its conquest by Alexander the Great in 332 B.C.\nConcepts: Specimen collection, venous (Operative procedure on vein)\tEgypt, Ancient (Ancient Lands)\tPredicted Mean Residence Time Infinity (Mean Residence Time)\tDifferentiation Antigen (Clinical Attribute)\tProduct containing peptide (Amino Acid, Peptide, or Protein)", + "output": "Egypt, Ancient (Ancient Lands)" + }, + { + "input": "Definition: regulation of potassium ion transport described as any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: Moderately Short of Breath (Finding)\tdown-regulation of potassium ion transport (Cell Function)\tBeverages, Food And (Technology, Industry, Agriculture)\tForming (Functional Concept)\tGLOVE, PATIENT EXAMINATION, VINYL (Medical Device)", + "output": "down-regulation of potassium ion transport (Cell Function)" + }, + { + "input": "Definition: root described as the large vein that terminates in the right atrium and transports deoxygenated blood from the head, neck, arms, and chest to the heart.\nConcepts: Hartley guinea pig (OTHER DOMESTIC ANIMAL SPECIES)\t2-Chloro-1,3-Butadiene (Alkadienes)\tAge of Onset (Symptom Onset Date)\tovary cancer, serous cystadenocarcinoma (Ovarian and fallopian tube cysts and neoplasms)\tVena cava, Superior (Veins)", + "output": "Vena cava, Superior (Veins)" + }, + { + "input": "Definition: something described as a rare chromosomal anomaly syndrome, resulting from the partial deletion of the short arm of chromosome X. The disease has principle characteristics of classical Norrie disease (bilateral, severe retinal malformations and opacity of the lens leading to congenital blindness, on occasion associated with progressive sensorineural deafness and intellectual disability), microcephaly, hypotonia, psychomotor and growth delay and moderate to severe mental handicap. Clinical phenotype is highly variable and immunodeficiency, epilepsy and hypogonadism have also been reported.\nConcepts: E2A/TFPT Fusion Gene (Gene or Genome)\torganizational behavior (Organizations & Organizational Behavior)\tAdenosine Diphosphate (adenosine monophosphate)\tTransport Injury (Injury or Poisoning)\tAtypical Norrie disease due to Xp11.3 microdeletion (Anomaly of chromosome X)", + "output": "Atypical Norrie disease due to Xp11.3 microdeletion (Anomaly of chromosome X)" + }, + { + "input": "Definition: Pharmacologic Substance described as an aromatase inhibitor with a non-steroidal structure. Non-steroidal aromatase inhibitors work by reversible competition with the enzyme.\nConcepts: Non-Steroidal Estrogen Synthase Inhibitor (Aromatase Inhibitors)\tActinobacillus ureae (Jones 1962) Mutters et al. 1986 (Bacterium)\tMontefiore syndrome (Mental Retardation)\tRetinopathy of Prematurity with Plus Disease (Disease or Syndrome)\tbeta-glucoside PTS transporter activity (beta-glucoside transmembrane transporter activity)", + "output": "Non-Steroidal Estrogen Synthase Inhibitor (Aromatase Inhibitors)" + }, + { + "input": "Definition: Genus: Lentivirus group described as a lentivirus that is similar to human immunodeficiency virus and that infects cattle.\nConcepts: Rex (Molecular Function)\tSezary cell count (Lymphoma Cell Count)\tEnamel abnormality (Abnormality of odontoid tissue)\tImmunodeficiency Viruses, Bovine (Lentiviruses, Bovine)\tAVL01043 (ADNI-AVLT Questionnaire Question)", + "output": "Immunodeficiency Viruses, Bovine (Lentiviruses, Bovine)" + }, + { + "input": "Definition: Sinks described as sinks designed for cleaning the hands of healthcare personnel, patients, or other individuals without connection to external water supplies and/or drainage. These sinks typically consist of a structure made of plastic and/or metal. The sinks usually include a freshwater tank, a wastewater tank, tubing, and faucets; they a soap dispenser, a paper towel rack, and an electrically powered water pump. Portable sinks are used in field operations during emergencies, in mobile medical facilities and shelters, and for disabled patients who cannot move from a location.\nConcepts: Portable Sinks (Sinks)\tall-trans-retinyl ester acylhydrolase, 11-cis retinol forming activity (carboxylic ester hydrolase activity)\tProtoplasts (Cell)\tstage IV AIDS-related lymphoma (Neoplastic Process)\tVein, Femoral (Structure of tributary of external iliac vein)", + "output": "Portable Sinks (Sinks)" + }, + { + "input": "Definition: Congenital Heart Defects described as congenital constriction of the aorta just distal to the left subclavian artery; causes upper body hypertension but few other symptoms; may present as headache or dyspnea on exertion.\nConcepts: N-acetylglucosamine-1-phosphotransferase deficiency (Disorder of glycoprotein metabolism)\tNeonatal Complications (Complication)\tAORTA, COARCTATION (Congenital anomaly of aorta)\tPerfusion - action (Injection procedure)\tStage IIB Non-Small Cell Lung Cancer (Neoplastic Process)", + "output": "AORTA, COARCTATION (Congenital anomaly of aorta)" + }, + { + "input": "Definition: response to ether described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ionomycin stimulus.\nConcepts: Streptococcus lutetiensis Poyart et al. 2002 (Streptococcus bovis group)\tresponse to ionomycin (response to ether)\tReticulonodular pattern on pulmonary HRCT (Finding)\tProstate Ductal Adenocarcinoma, Cribriform Pattern (Endometrioid carcinoma of prostate)\tTranscription Factor, STAT2 (Amino Acid, Peptide, or Protein)", + "output": "response to ionomycin (response to ether)" + }, + { + "input": "Definition: carboxy-lyase activity described as catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2.\nConcepts: prnatl hmebrth nvrmnt prep e (Therapeutic or Preventive Procedure)\tMHBMA (Organic Chemical)\tParasternal short axis view at the mitral valve level (Spatial Concept)\tFAC005-One/Both Arms Are Swollen/Tender (FACT-B Version 4 Questionnaire Question)\t3-polyprenyl 4-hydroxybenzoate decarboxylase activity (Molecular Function)", + "output": "3-polyprenyl 4-hydroxybenzoate decarboxylase activity (Molecular Function)" + }, + { + "input": "Definition: Transferrin measurement described as the determination of the amount of transferrin with a reduced number of carbohydrate moieties present in a biological sample.\nConcepts: ASSAY OF CARBOHYDRATE DEFICIENT TRANSFERRIN (Laboratory Procedure)\tGAD0109 (Intellectual Product)\tHEALTH OCCUP (Finnish translations of the Medical Subject Headings)\tGrade 1 Ejaculation Disorder, CTCAE (Ejaculation Disorder, CTCAE)\tSoft Serve Ice Cream Freezer (Diagnostic, Therapeutic, and Research Equipment)", + "output": "ASSAY OF CARBOHYDRATE DEFICIENT TRANSFERRIN (Laboratory Procedure)" + }, + { + "input": "Definition: Idea or Concept described as a role used to link a gene with its physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range for this role are 'Gene' and 'Anatomic Structure, System, or Substance', respectively.\nConcepts: Grade 3 Sore Throat, CTCAE (Sore Throat, CTCAE)\tGene Has Physical Location (NCI Thesaurus Role)\tbiomedical engineering field (Health Occupations)\tcarbon catabolite repression of transcription from RNA polymerase II promoter by galactose (carbon catabolite repression of transcription by galactose)\tSP-A Receptor Subunit SP-R210 (Cytoskeletal Proteins)", + "output": "Gene Has Physical Location (NCI Thesaurus Role)" + }, + { + "input": "Definition: New client in-office without ICD diagnosis described as using homeopathic assessment methods in a comprehensive, 60-minute, in-office meeting to assess the health status of a new homeopathy client to develop a homeopathic treatment plan.\nConcepts: new60min inofc homeo ntak (New client in-office without ICD diagnosis)\tWHODAS 2.0 12+24-item Version Interviewer-administered - How Many Days Reduce Activities (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tPharmacogenomics Alternative Sequence Coverage (Alternative Sequence Read Depth)\taccessory olfactory cortical areas (Body Location or Region)\tMNSI - Feet Too Sensitive to Touch (MNSI Questionnaire Question)", + "output": "new60min inofc homeo ntak (New client in-office without ICD diagnosis)" + }, + { + "input": "Definition: Tooth structure described as agenesis of one or more maxillary lateral incisor, comprising the maxillary lateral primary incisor and maxillary lateral secondary incisor.\nConcepts: Vitamin B5 deficiency (Finding)\tFailure of development of maxillary lateral incisor (Tooth structure)\tSer (Body substance)\trRNA 2'-O-ribose methylation guide activity (RNA 2'-O-ribose methylation guide activity)\tMEGDEL syndrome (Developmental Disabilities)", + "output": "Failure of development of maxillary lateral incisor (Tooth structure)" + }, + { + "input": "Definition: Subdivision of mediastinum described as the part of the mediastinum that is located between the upper part of the sternum in the front and the upper thoracic vertebrae in the back.\nConcepts: Superior mediastinal part of chest (Subdivision of intrathoracic part of chest)\tgranulomatous rosacea (Inflammatory dermatosis)\tBody Mass Index Greater than or Equal to 30 (Body Mass Index Greater Than or Equal to 23)\tmannose PTS transporter activity (Molecular Function)\tPODCI1-Outdoor Limited by: Season (PODCI Pediatric Parent-Reported Version Questionnaire Question)", + "output": "Superior mediastinal part of chest (Subdivision of intrathoracic part of chest)" + }, + { + "input": "Definition: something described as a measurement of the alpha fetoprotein activity in a biological specimen.\nConcepts: DNA, Ancient (DNA)\tregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria (regulation of antibacterial peptide biosynthetic process)\tAFPA (Laboratory Procedure)\tUterine Corpus Lipomatous Leiomyoma (Neoplastic Process)\trhombomere 5 formation (rhombomere formation)", + "output": "AFPA (Laboratory Procedure)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the degree to which an individual feels desperate right now.\nConcepts: Phosphorylases, Pyrimidine (Amino Acid, Peptide, or Protein)\tPrinters, Laser, Color (Laser printer)\tDesperate (Clinical or Research Assessment Question)\tReductase, Ferredoxin-Nitrite (Oxidoreductase)\tstomatitis; angular (Skin Diseases, Bacterial)", + "output": "Desperate (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Journal described as a publication that contains original articles that have been written by scientists and evaluated for technical and scientific quality and correctness by other experts in the same field.\nConcepts: peer-reviewed scientific journal (Journal)\tPeriods (Organism Function)\tFLUORIDE (Laboratory Procedure)\tnucleobase-containing compound transmembrane transporter activity (transmembrane transporter activity)\tImmunotherapy-related (Finding)", + "output": "peer-reviewed scientific journal (Journal)" + }, + { + "input": "Definition: Cell described as any autologous or allogeneic immune cell that has been genetically modified.\nConcepts: Genetically-modified Immune Cell (Adoptive Cell Therapy Agent)\tLevel of Sexual Arousal During Sexual Activity or Intercourse (Clinical or Research Assessment Question)\tPerformedDiagnosis.priorityAtDischargeCode (Priority at Discharge Code)\tIn Urine (metabolic aspects)\tFDA Establishment Activity Terminology (Intellectual Product)", + "output": "Genetically-modified Immune Cell (Adoptive Cell Therapy Agent)" + }, + { + "input": "Definition: something described as extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix.\nConcepts: Vena submentalis (Veins)\tPowder and solvent for injection solution (Drug powder and solvent)\tstriatum development (Organ or Tissue Function)\tCrus of helix connected to antihelix (Abnormality of the crus of the helix)\tSlide Stainers, Hematology (Microscope slide stainer)", + "output": "Crus of helix connected to antihelix (Abnormality of the crus of the helix)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as consent given by a subject, or in the case of an individual that can only give assent, by a parent or legal guardian, for the participation in a clinical study only after having achieved an understanding of both the relevant medical facts and the relevant risks involved.\nConcepts: response to oomycetes (Organism Function)\tPromyeloblasts Measurement (Laboratory Procedure)\tRefractory Ovarian Endometrioid Adenocarcinoma (Neoplastic Process)\tInformed Consent (Patient Rights)\tommochrome breakdown (Molecular Function)", + "output": "Informed Consent (Patient Rights)" + }, + { + "input": "Definition: Sodium disorder described as lower than normal levels of sodium in the circulating blood.\nConcepts: Regional (Topographical modifier)\tcolon, adenocarcinoma of the (Intestinal Cancer)\tIntracystic Papillary Adenoma (Papilloma, Intraductal)\tHyponatremia, NOS (Symptomatology)\to-methyldiphenhydramine (Muscle Relaxing Drugs)", + "output": "Hyponatremia, NOS (Symptomatology)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tacrolimus stimulus.\nConcepts: Caffey pseudo-Hurler syndrome (Disease or Syndrome)\tcals (Nutrition, Dietary Components)\toxidoreductase activity, acting on phosphorus or arsenic in donors (oxidoreductase activity)\tCross Cultural Counseling (Cross Cultural Treatment)\tresponse to tacrolimus (drug response)", + "output": "response to tacrolimus (drug response)" + }, + { + "input": "Definition: Indication of described as a rationale for excluding a particular data point or subject from the statistical analysis.\nConcepts: Long chain 3-hydroxyacyl CoA dehydrogenase deficiency (Disease or Syndrome)\tDesert Hedgehog Protein (Signaling Protein)\tMismatched Related Donor (Human)\tPORTER SILBER HYDRAZONE, 17-HYDROXYCORTICOSTEROIDS (Indicator, Reagent, or Diagnostic Aid)\tREASEX (Intellectual Product)", + "output": "REASEX (Intellectual Product)" + }, + { + "input": "Definition: Finding described as sphenoid and occiput have rotated in opposite directions around an anterior-posterior (A-P) axis. SBS torsions are named for the high greater wing of the sphenoid, right or left.\nConcepts: chyles (Lymph)\tPseudoephedrine/Loratadine (loratadine)\tPericardial Sarcoma (Sarcoma of soft tissue)\tHibernomas (Lipomatous neoplasm)\tSphenobasilar Synchondrosis Torsion (Finding)", + "output": "Sphenobasilar Synchondrosis Torsion (Finding)" + }, + { + "input": "Definition: Gram Negative Bacteria described as a family of gram-negative bacteria, in the order Thiotrichales.\nConcepts: Family Piscirickettsiaceae (Bacterium)\tfamilies (Thesaurus of Psychological Index Terms)\tbasal dendrite arborization (Dendritic Arborization)\tHave Dry or Itchy Skin (Intellectual Product)\tSatisfaction with How Comfortably Bras Fit (Clinical or Research Assessment Question)", + "output": "Family Piscirickettsiaceae (Bacterium)" + }, + { + "input": "Definition: Laboratory or Test Result described as ABO phenotype B, corresponding to the genotype BO or BB. []\nConcepts: Clinicaltrials.gov NCT Number for the Expanded Access Record (Intellectual Product)\teyes proteins (Proteins)\tpositive regulation of pyloric antrum smooth muscle contraction (Organ or Tissue Function)\tblood group b (Blood grouping and cross-matching analyses)\tLaser Microdissection Systems (Medical Device)", + "output": "blood group b (Blood grouping and cross-matching analyses)" + }, + { + "input": "Definition: Body Location or Region described as a subdivision of the cytoarchitecturally defined postcentral region of cerebral cortex. In the human it is located in the postcentral gyrus where it is bounded cytoarchitecturally by the area 3 of Brodmann (human) and the area 2 of Brodmann (human) and, at its ventral tip, by the area 43 of Brodmann (human) ( Brodmann-1909 ).\nConcepts: Generalised moderate chronic periodontitis (Generalized chronic periodontitis)\tBrodmann area 1 (Brodmann area)\tGrade 4 Ventricular arrhythmia (Finding)\tOrbital Sarcoma pT0 TNM Finding v8 (Orbital Sarcoma Pathologic Primary Tumor TNM Finding v8)\tQLES1-Concentrate on Leisure Activities (Q-LES-Q Questionnaire Question)", + "output": "Brodmann area 1 (Brodmann area)" + }, + { + "input": "Definition: Intellectual Product described as software designed to operate physiologic measuring instruments, control/monitor a limited number of their functions, and/or process data obtained while measuring. This software is intended to work only with one or a few models of physiologic measuring instruments, usually from the same manufacturer. The software may perform a variety of algorithms to facilitate the operation and analysis of the measurements. Physiologic measuring software is not usually available separate from the tester but may be updated (i.e., through the release of modified versions) during the life of the measuring instrument. Dedicated physiologic measuring software intended for a great variety of measurements (e.g., cardiac output, spirometry, blood pressure) is available.\nConcepts: IDS-C - Sexual Interest (Intellectual Product)\tRal-GDS-Related Protein, human (Guanine Nucleotide Exchange Factors)\tPhysiologic Measurement Software (Computer software)\tmannose:proton symporter activity (Molecular Function)\tInternally nucleated skeletal muscle fibres (Abnormal sarcomere morphology)", + "output": "Physiologic Measurement Software (Computer software)" + }, + { + "input": "Definition: Next Generation Targeted Sequencing described as a type of whole transcriptome shotgun sequencing technique in which select portions of the transcriptome are selected for sequencing.\nConcepts: Proctoscope, device (Flexible endoscope)\t8: 6408172-6347601 (Chromosome 8 Physical Location)\tExtremity Hand Positioning (Clinical or Research Assessment Question)\tnegative regulation of interferon-beta production (negative regulation of type I interferon production)\tTARGETED TRANSCRIPTOME SEQUENCING (Next Generation Targeted Sequencing)", + "output": "TARGETED TRANSCRIPTOME SEQUENCING (Next Generation Targeted Sequencing)" + }, + { + "input": "Definition: Image Feature described as characteristic of the clarity of the boundary or edges of a finding or feature.\nConcepts: Amino-terminal pro-brain natriuretic peptide (Biologically Active Substance)\tGastric Cancer cM0 TNM Finding v7 (Gastric Cancer Clinical Distant Metastasis TNM Finding v7)\tBorder Definition (Image Feature)\tT cell meandering search (T cell migration)\tPrevious Labeling Company (Company)", + "output": "Border Definition (Image Feature)" + }, + { + "input": "Definition: Genetic Function described as any process that decreases the frequency, rate or extent of heterochromatin assembly by small RNA.\nConcepts: ATRX Mutation Analysis Was Not Performed (Mutation Analysis Was Not Performed)\tno effect (Clinical or Research Assessment Answer)\tnegative regulation of RNAi-mediated heterochromatin assembly (negative regulation of heterochromatin assembly)\tGonadal calcification (Abnormal internal genitalia)\tcricoarytenoideus (Laryngeal muscle structure)", + "output": "negative regulation of RNAi-mediated heterochromatin assembly (negative regulation of heterochromatin assembly)" + }, + { + "input": "Definition: something described as electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.\nConcepts: dense core granule (Cell Component)\tRAYS (Batoidea)\tMetabolic Control (Molecular Function)\toxidation-dependent protein degradation (modification-dependent protein catabolic process)\tMED SOCIOL (Biomedical Occupation or Discipline)", + "output": "dense core granule (Cell Component)" + }, + { + "input": "Definition: Organic Chemical described as azo compounds consisting of an aryl or alkyl group that is joined through two nitrogen atoms to an anion (R-N2+X-).\nConcepts: Cervical lymphocele with bowed long bones (Congenital Abnormality)\tSGRQ02-Describe Your Resp Condition (Intellectual Product)\tlipoyl(octanoyl) transferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tBoard Eligible (Qualitative Concept)\tDIAZONIUM CPDS (Azo Compounds)", + "output": "DIAZONIUM CPDS (Azo Compounds)" + }, + { + "input": "Definition: Abnormal curvature described as an appreciable lateral deviation in the normally straight vertical line of the spine.\nConcepts: placoda otica development (Organ or Tissue Function)\tScoliosis deviation of spine (Bones, Joints and Muscles)\t17q21-q22 (Cell Component)\tSubtyping, Immunologic (Laboratory Procedure)\tRecurrent T Acute Lymphoblastic Leukemia (Precursor T-lymphoblastic lymphoma/leukemia recurrent)", + "output": "Scoliosis deviation of spine (Bones, Joints and Muscles)" + }, + { + "input": "Definition: pteridine-containing compound metabolic process described as the chemical reactions and pathways involving tatiopterin.\nConcepts: isonicotinic acid hydrazide hydrolase activity (Molecular Function)\tnatural regeneration (Cyclic tissue alteration)\tSynthetase, Methionine (Transferase)\tANTISERA, AGGLUTINATING, B. PARAPERTUSSIS (Indicator, Reagent, or Diagnostic Aid)\ttatiopterin metabolic process (phosphorus metabolism)", + "output": "tatiopterin metabolic process (phosphorus metabolism)" + }, + { + "input": "Definition: ECG Measurement described as the average elevation of the ST segment, obtained from a set of measurements of the elevation of the ST segment.\nConcepts: TLH (Oxidoreductase Gene)\tFemale Castrations (Complete excision)\tMean ST Segment Elevation (Finding)\tDeficiency of vitamin K (Hemorrhagic Disorders)\t17: 71229111-71265494 (Spatial Concept)", + "output": "Mean ST Segment Elevation (Finding)" + }, + { + "input": "Definition: something described as the approximate intake in one day of a polyunsaturated, omega 6 and essential fatty acid with an 18 carbon chain length and two cis double bonds (18:2).\nConcepts: 2,7,4'-trihydroxyisoflavanone-4'-O-methyltransferase activity (methyltransferase activity)\tGrade 3b (Lymphoma, Large-Cell, Follicular)\tResistance to Second-Generation Androgen Receptor Axis-Targeted Agents (Finding)\tProcedure Portion or Totality (Portion or Totality)\tEstimated intake of linoleic acid in 24 hours (Linoleic acid intake)", + "output": "Estimated intake of linoleic acid in 24 hours (Linoleic acid intake)" + }, + { + "input": "Definition: Neoplastic Process described as an unusual variant of capillary hemangioma. It is characterized by a unique anastomosing sinusoidal-like architecture which may mimic angiosarcoma. It was originally described in the kidney but rare cases have been reported in other sites.\nConcepts: Poisoning risk (Health perception, health management pattern)\tAnastomosing Hemangioma (Neoplastic Process)\tpyranose-2-oxidase activity (oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor)\tRecombinant Adenovirus-hIFN-beta (Adenovirus Vaccine)\tMalignant Uvea Neoplasm (Uveal Neoplasms)", + "output": "Anastomosing Hemangioma (Neoplastic Process)" + }, + { + "input": "Definition: Infection status described as severity of signs and symptoms of infection during the first 28 days of life\nConcepts: g force (Force)\tInfection severity: newborn (Immune response)\tAdenoid Cystic Carcinoma of the Major Salivary Gland (Major Salivary Gland Carcinoma)\tN-RAS Gene Amplification (Gene Amplification Abnormality)\t11q13.4 (Cell Component)", + "output": "Infection severity: newborn (Immune response)" + }, + { + "input": "Definition: Pharmacologic Substance described as agents that inhibit PROTEIN KINASES.\nConcepts: Grade 3 Sinus Tachycardia, CTCAE (Finding)\tCES01 (Clinical or Research Assessment Questionnaire)\tTabulation Dataset (Intellectual Product)\tPROTEIN KINASE INHIB (Pharmacologic Substance)\tFive Hundred (Quantitative Concept)", + "output": "PROTEIN KINASE INHIB (Pharmacologic Substance)" + }, + { + "input": "Definition: Carcinoma described as a malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women.\nConcepts: Acinar Carcinomas (Carcinoma)\tCRQ0220 (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\tDDS03-Worry About Low Blood Sugars (Intellectual Product)\tStents, Pancreatic (Medical Device)\tGsalpha Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Acinar Carcinomas (Carcinoma)" + }, + { + "input": "Definition: Pharmacologic Substance described as a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.\nConcepts: Reduced nicotinamide adenine dinucleotide dehydrogenase (Enzyme)\tEXTRAP (Functional Concept)\tRidaforolimus (mTOR Inhibitor)\tCabinets, Treatment, Ultraviolet (Durable Medical Equipment)\tcounseling intervention (Thesaurus of Psychological Index Terms)", + "output": "Ridaforolimus (mTOR Inhibitor)" + }, + { + "input": "Definition: Calcium Channel Blocking Agents, Dihydropyridines described as a calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.\nConcepts: N-acetyl-beta-D-glucosaminidase Excretion Rate (Laboratory Procedure)\tALK Fusion Positive (Rearrangement Detected)\tNimodipine-containing product (Nitrogen and nitrogen compound)\tLaryngeal Route of Drug Administration (RouteBySite)\tAbnormal Serum Immunoglobulin Kappa to Lambda Free Light Chain Ratio (Laboratory or Test Result)", + "output": "Nimodipine-containing product (Nitrogen and nitrogen compound)" + }, + { + "input": "Definition: something described as the presence of a thrombus within a vascular shunt.\nConcepts: Shunt Thrombosis (Pathologic Function)\tCongenital ichthyosis unspec. (Skin Abnormalities)\tdenticles (Dental Pulp Diseases)\tlipoxygenase pathway (Fatty Acid Metabolism Pathway)\tCCQ01TN (Intellectual Product)", + "output": "Shunt Thrombosis (Pathologic Function)" + }, + { + "input": "Definition: Body Location or Region described as organ surface layert which constitutes the outermost layer of an organ.\nConcepts: Radiologist 1 (radiologist)\tAmide (Amine and amine derivative)\tspheroidene catabolism (xanthophyll catabolic process)\tOrgan external surface layer (Body Location or Region)\tMNB (DYRK1A gene)", + "output": "Organ external surface layer (Body Location or Region)" + }, + { + "input": "Definition: Cell Function described as a signal transduction process that contributes to a meiotic spindle assembly checkpoint.\nConcepts: Blasts Less than or Equal to 15 Percent of Bone Marrow Nucleated Cells (Blasts Under 20 Percent of Bone Marrow Nucleated Cells)\tdownregulation of hydrolase activity (regulation of hydrolase activity)\tsignal transduction involved in meiotic spindle assembly checkpoint (intracellular signal transduction involved in meiotic spindle checkpoint)\tregulation of mitochondrial mRNA stability (Genetic Function)\tpost-embryonic hindlimb morphogenesis (Organism Function)", + "output": "signal transduction involved in meiotic spindle assembly checkpoint (intracellular signal transduction involved in meiotic spindle checkpoint)" + }, + { + "input": "Definition: Intellectual Product described as patient Determined Disease Steps test code.\nConcepts: MMSE-2 Standard Version - Recall Word 2 (MMSE-2 Standard Version Functional Test Question)\tManaged Care Organizations; Point of Service (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tPDDS01TC (CDISC Questionnaire Terminology)\toxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor (oxidoreductase activity, acting on a heme group of donors)\trecombinant CD40-ligand (Amino Acid, Peptide, or Protein)", + "output": "PDDS01TC (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: RHOA gene described as human RHOA wild-type allele is located in the vicinity of 3p21.3 and is approximately 53 kb in length. This allele, which encodes transforming protein RhoA, is involved in the modulation of actin cytoskeletal organization.\nConcepts: Antimanic Agents (Pharmacologic Substance)\tRHOA wt Allele (Gene or Genome)\tregulation of lateral plate mesodermal cell fate determination (regulation of mesodermal cell fate determination)\tgenome (GENES: GENERAL TERMS)\tNCI Program (Extramural Funding Mechanisms)", + "output": "RHOA wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as rockport One Mile Walk Test - Time to complete one-mile walk.\nConcepts: Ets-family Transcription Factor Inhibitor TK216 (Pharmacologic Substance)\tup-regulation of L-dopa decarboxylase activity (positive regulation of lyase activity)\thorizontal nucleus of the diagonal band (Body Part, Organ, or Organ Component)\tROCK01-Time To Complete One Mile Walk (RFWT Version 1 Functional Test Question)\tParanasal Sinus Stent Delivery Kits (Stent Delivery Kits)", + "output": "ROCK01-Time To Complete One Mile Walk (RFWT Version 1 Functional Test Question)" + }, + { + "input": "Definition: something described as increase or decrease in insoluble fibre content of the diet.\nConcepts: NCAM1 Expressing Cell Measurement (Laboratory Procedure)\tHistone Deacetylation (protein deacetylation)\tInsoluble fiber modified diet (Modified fiber diet)\tAmino Acid Transport System y+ (Amino Acid Transport Systems, Basic)\tMedullary Thyroid Carcinoma TNM Finding v8 (Finding)", + "output": "Insoluble fiber modified diet (Modified fiber diet)" + }, + { + "input": "Definition: positive regulation of small molecule metabolic process described as any process that activates or increases the frequency, rate or extent of asperthecin biosynthetic process.\nConcepts: Satisfaction (Emotions)\tReceptor, P2X4 (Receptors, Purinergic P2X)\tBody Weight Maintenance (Body Weight)\tCLOSTRIDIUM SEPTICUM (Clostridium species q-z)\tup-regulation of asperthecin formation (positive regulation of secondary metabolite biosynthetic process)", + "output": "up-regulation of asperthecin formation (positive regulation of secondary metabolite biosynthetic process)" + }, + { + "input": "Definition: something described as tree section heading term for specific named groups; do not index.\nConcepts: UPD2307A (MDS-UPDRS Questionnaire Question)\tcalcium-dependent protein kinase regulator activity (protein kinase regulator activity)\tpopulations special (high-risk group and special population)\tCerebellar granular layer atrophy (Disease or Syndrome)\tDoppler Ultrasonography, Transcranial (Echoencephalography)", + "output": "populations special (high-risk group and special population)" + }, + { + "input": "Definition: Disease or Syndrome described as a type of microscopic colitis of unknown etiology. It is characterized by the presence of collagen deposits in the lamina propria of the colonic mucosa. Patients present with chronic watery diarrhea. Colonoscopy reveals normal-appearing mucosa. The diagnosis is made with the microscopic examination of the colonic biopsy samples.\nConcepts: Ig Kappa Chain V-I Region D-13 (Immunoproteins)\thippocampal formation (Body Part, Organ, or Organ Component)\tComputer/Peripheral Device Switches (Information/Telecommunications Systems)\tCollagenous colitis (Disease or Syndrome)\tCranial nerve nuclei, NOS (Body Part, Organ, or Organ Component)", + "output": "Collagenous colitis (Disease or Syndrome)" + }, + { + "input": "Definition: G-protein coupled receptor activity described as combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes.\nConcepts: bioactive lipid receptor activity (Molecular Function)\tTesticular Sex Cord-Stromal Tumor (Neoplastic Process)\t5q23-q32 (Chromosome band)\tMusculus papillaris posterior ventriculi sinistri (Region of papillary muscle)\tArteriovenous fistula, congenital (Arteriovenous fistula)", + "output": "bioactive lipid receptor activity (Molecular Function)" + }, + { + "input": "Definition: something described as enables the transfer of potassium ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.\nConcepts: high-affinity potassium ion transmembrane transporter activity (Molecular Function)\tATP6AP1 gene (Gene or Genome)\tElectrically Controlled Extended Release Patch (Extended Release Patch Dosage Form)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Antineutrophil Cytoplasmic Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune)\tNUP98/PRRX1 Fusion Gene (Fusion Gene)", + "output": "high-affinity potassium ion transmembrane transporter activity (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a focal autonomic seizure characterised by impaired awareness at some point within the seizure.\nConcepts: Microparticle-encapsulated CYP1B1-encoding DNA Vaccine ZYC300 (Gene Therapy Agent)\tLocalized autonomic seizure with altered responsiveness (Focal autonomic seizure)\tC-terminal peptidyl-methionine amidation (protein C-terminal amidation)\tConvergent squint (Esotropia)\tDifficulty concentrating (Clinical or Research Assessment Question)", + "output": "Localized autonomic seizure with altered responsiveness (Focal autonomic seizure)" + }, + { + "input": "Definition: something described as terminology related to the parameter codes of the challenge agent characteristics within a study.\nConcepts: Challenge Agent Parameter Code (CDISC SEND Terminology)\tuterine muscles (Body Part, Organ, or Organ Component)\tBCL2 family apoptosis regulator BOK (Gene or Genome)\tpositive regulation of interleukin-8 biosynthesis (positive regulation of cytokine biosynthetic process)\tTubulin (Amino Acid, Peptide, or Protein)", + "output": "Challenge Agent Parameter Code (CDISC SEND Terminology)" + }, + { + "input": "Definition: something described as a finding about one or more characteristics of sarcoma of the orbit, following the rules of the TNM AJCC v7 classification system. No stage grouping is presently recommended for sarcoma of the orbit.\nConcepts: Drowsiness Score 0 (Drowsiness Visual Analogue Scale)\tImmunologic Factor Activation (Multicellular Process)\tblood vessel endothelial cell migration (Cell Function)\tTeninitis (Musculoskeletal Diseases)\tSarcoma of the Orbit TNM Finding v7 (Finding)", + "output": "Sarcoma of the Orbit TNM Finding v7 (Finding)" + }, + { + "input": "Definition: catheter device described as a small, flexible tube used to deliver fluids into the body. A needle is used to insert the catheter into a vein, usually in the back of the hand or in the forearm. The tubing is then taped to the skin to hold it in place.\nConcepts: 89Zr-labeled nanocolloid human serum albumin (Amino Acid, Peptide, or Protein)\tPQL1501 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)\tperipheral venous catheter (catheter device)\tIntraoper cholangiogram (Diagnostic radiography during operative procedure)\tup-regulation of protein localisation to kinetochore (regulation of protein localization to kinetochore)", + "output": "peripheral venous catheter (catheter device)" + }, + { + "input": "Definition: Manufactured Object described as devices consisting of a surface mounted on a supporting structure that is designed to display images obtained from projectors with a size and optical characteristics that allow the view of the images by a large number of people. These screens typically provide a flat or curved surface (e.g., matte white) frequently made of fabrics which size, aspect ratio (e.g., 1:1; 4:3; 16:9), and optical characteristics (e.g., uniformity, viewing angle, definition) are appropriate for a given location (e.g., auditorium, conference rooms, classrooms, home theater). Projector screens may be permanently mounted on a rigid frame or rolled (manually or electric-powered) in a ceiling or other supporting structure (e.g., free standing, tripods) when not in use; painted walls are also used as screens. Dedicated screens appropriate to satisfy the characteristics of the projection method used (e.g., video), such as liquid crystal device (LCD), digital micro-mirror device (DMD), and 35 mm transparency are available. Projection screens are used in healthcare facilities for many purposes, including analysis of medical procedures, education of staff and patients, review of clinical laboratory slides, and ophthalmology tests.\nConcepts: Taxol Resistance Associated Gene 3 (Gene or Genome)\tProjector Screens (Manufactured Object)\tChoroid Tumor (Disorder of choroid of eye)\tBlood Grouping Systems, Automated (Analyzers, Laboratory, Hematology, Blood Grouping)\tacyl-CoA N-acyltransferase activity (N-acyltransferase activity)", + "output": "Projector Screens (Manufactured Object)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the collagen, type IX, alpha 2 (COL9A2) gene, located at chromosome 1p33-p32, which encodes for collagen type IX alpha 2, the major collagen component of hyaline cartilage. Mutations at this locus have been identified in patients with multiple epiphyseal dysplasia type II.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL9A2 (Medical Device)\tSeed entity (Conceptual Entity)\ttgf-beta 2 (Amino Acid, Peptide, or Protein)\tFACT-COG Version 3 - Cognitive Impairments Score (FACT-COG Version 3 Questionnaire Question)\tSocial contact (PSYCHOSOCIAL DOMAIN)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL9A2 (Medical Device)" + }, + { + "input": "Definition: Medical Device described as detectors designed to facilitate the visualization and identification of abnormalities in the periodontal and oral cavity tissues using fluorescent light. These devices are typically a light source (usually blue) that causes tissue fluorescence; healthy tissue observed through the handpiece has a bright green color, while abnormal and/or suspicious tissue appears darker due to a loss of fluorescence. Induced fluorescence periodontal/oral cavity tissue abnormality examination detectors are used by dental and other healthcare providers to identify abnormal tissue (e.g., oral cancer, dysplasia) that is not apparent in visible light; the devices are also used by surgeons to help distinguish diseased tissue that should be resected.\nConcepts: olfactory entorhinal cortex (Body Part, Organ, or Organ Component)\tInduced Fluorescense Periodontal Tissue Abnormality Detectors (Detectors)\tPlay Basketball, Soccer, or Racquetball (Intellectual Product)\tL-lysine degradation to acetyl-CoA via saccharopine (Molecular Function)\tDefined Activity Repeat Quantity (Repeat Quantity)", + "output": "Induced Fluorescense Periodontal Tissue Abnormality Detectors (Detectors)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the angiotensin I hormone in a biological specimen.\nConcepts: MPF complex (Cell Component)\tdown regulation of oviposition (regulation of oviposition)\tClostridium botulinum Toxin F3 (Hazardous or Poisonous Substance)\tAngiotensin I Assay (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tLife Scientists (Professional or Occupational Group)", + "output": "Angiotensin I Assay (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the TGFB-induced factor homeobox 1) (TGIF1)(formerly TGIF) gene, located at chromosome 18p11.3, which encodes for a protein that is a transcription regulator. This inherited genetic mutation has been identified in patients with early-onset holoprosencephaly-4.\nConcepts: Hodgkin's disease, stage IV, adult (Adult Hodgkin Lymphoma by Ann Arbor Stage)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TGIF1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tStage IVA Mucosal Melanoma of the Head and Neck (Neoplastic Process)\tIVD Test Reagent/Kits, Microbiology, Fungi/Yeast, Culture Media, Dehydrated (Medical Device)\tSpirochaetaceae Swellengrebel 1907 (Phylum Spirochaetes)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TGIF1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: RNA localization to nucleus described as a process in which an RNA is transported to, or maintained in, a Cajal body.\nConcepts: Clips, Implantable, Eye, Wound (Clips, Implantable, Eye)\tAnimals (Chordata)\tRNA localization to Cajal body (RNA localization to nucleus)\tvestibulo ocular reflex (Vestibulocochlear Physiological Phenomena)\tbathing trunk nevus (Nevus AND/OR melanoma)", + "output": "RNA localization to Cajal body (RNA localization to nucleus)" + }, + { + "input": "Definition: Intellectual Product described as diabetes Distress Scale for Partners of Adults with Type 1 Diabetes - During the past month, I have been: Concerned that my partner and I are not working well together when it comes to diabetes.\nConcepts: DDS0320 (Intellectual Product)\tSGRQ Past 4 Weeks Version - Washing or Dressing Yourself (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)\tlytic (Qualitative Concept)\tInterlaboratory (General Qualifier)\tleptin receptor overlapping transcript like 1 (Signaling Pathway Gene)", + "output": "DDS0320 (Intellectual Product)" + }, + { + "input": "Definition: something described as muscle strength exercisers designed to provide resistance to muscular contraction using a pneumatic mechanism when the user performs exercises of the upper limbs and/or the trunk muscles. These exercisers usually consist of a stand-alone machine with a pneumatic mechanism, a system to transmit the force (i.e., to convey the resistance), and lever bars on which the user exerts force to counteract the exerciser resistance. Upper limb/trunk muscle strength exercisers can be used to exercise the upper limb (e.g., bicep curl, triceps extension) and/or trunk (front pull down, chest press, bent over row, abdominal crunch) muscles. They are intended to improve muscle strength in the upper limbs (arm, shoulder, elbow, forearm, and wrist) and/or trunk.\nConcepts: GAS CHROMATOGRAPHY, SALICYLATE (Medical Device)\tGrade 4 Proctitis (Proctitis, CTCAE)\tPhantom limb syn w'out pain (Phantom Limb Syndrome)\tUpper Limb/Trunk Pneumatic Exerciser (Exercisers, Muscle Strength, Pneumatic)\tR360120 (RAND-36 Questionnaire Question)", + "output": "Upper Limb/Trunk Pneumatic Exerciser (Exercisers, Muscle Strength, Pneumatic)" + }, + { + "input": "Definition: peptidyl-tyrosine modification described as the modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link.\nConcepts: Penile Urethral Malignant Neoplasm (Male Urethral Malignant Neoplasm)\tpeptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine (peptidyl-tyrosine modification)\tindex (Intellectual Product)\tProlactin-Induced Protein Gene (Gene or Genome)\tGrade 3 Dysarthria (Finding)", + "output": "peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine (peptidyl-tyrosine modification)" + }, + { + "input": "Definition: something described as this gene plays a role in signal transduction and regulation of transcription.\nConcepts: CHUK gene (Signaling Pathway Gene)\tGovernmentFunding (Funding Mechanism)\tRegimen Used to Treat Malignant Skin Neoplasm (Therapeutic or Preventive Procedure)\tTHYROGLOBULIN, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tFollicular Carcinoma of Thyroid (Follicular neoplasm of thyroid)", + "output": "CHUK gene (Signaling Pathway Gene)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the ATP binding cassette subfamily C member 8 (ABCC8) gene, located at chromosome 11p15.1, which encodes the protein ATP-binding cassette sub-family C member 8. Genetic variants at this locus have been associated with transient neonatal diabetes mellitus 2, permanent neonatal diabetes mellitus, persistent hyperinsulinemic hypoglycemia of infancy, leucine-induced hypoglycemia, and diabetes mellitus type 2.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ABCC8 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\toxalosuccinate decarboxylase activity (Molecular Function)\tAbnormal circulating porphyrin concentration (Abnormal circulating metabolite concentration)\tIntramuscular route (Functional Concept)\tTablet for conventional release rectal suspension (Tablet Dosage Form)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ABCC8 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: something described as see intervention.\nConcepts: IL-7 (cytokine binding)\t1-18:2-2-18:1-phosphatidylcholine desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)\tINOTUZUMAB OZOGAMICIN (Monoclonal antibodies, antineoplastic)\tNeoplasm, Retinal (Eye Neoplasms)\tProtocol Agent (Agent)", + "output": "Protocol Agent (Agent)" + }, + { + "input": "Definition: Domain described as a domain of the Activity Card Sort (ACS) related to low-physical-demand leisure activities that may be part of an individual's routine such as puzzles, quilting, and photography.\nConcepts: Low-Demand Leisure Activities Domain (Domain)\tAmine, Biogenic (Hydrocarbons and chemical classes)\tFormestane product (Estrogen Antagonists)\tNeurohypophysis dysplasia (Abnormality of the posterior pituitary)\tDuodenal Refluxs (Disease or Syndrome)", + "output": "Low-Demand Leisure Activities Domain (Domain)" + }, + { + "input": "Definition: Immune system described as a thin tube that carries lymph (lymphatic fluid) and white blood cells through the lymphatic system.\nConcepts: lymphatic vessel (Lymphoid Tissue)\tIDSR117 (IDS-SR Questionnaire Question)\tOromucosal Patch Dosage Form (Biomedical or Dental Material)\tChronic Sphenoidal Sinusitis (Disease or Syndrome)\tB4 cell group (serotonergic cell groups)", + "output": "lymphatic vessel (Lymphoid Tissue)" + }, + { + "input": "Definition: something described as a peptide cancer vaccine comprised of peptides derived from the Wilms tumor gene 1 (WT1) protein, with potential immunomodulating and antineoplastic activities. Upon administration, WT1 protein-derived peptide vaccine DSP-7888 may induce a specific cytotoxic T-lymphocyte (CTL) response against WT1-overexpressing tumor cells. In addition, DSP-7888 induces a helper T-lymphocyte-mediated immune response against WT1 expressing tumor cells. WT1 protein, a zinc finger DNA-binding protein and transcription factor, is overexpressed in leukemic cells and in many non-hematological solid tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121957\" active clinical trials using this agent.\nConcepts: WT1 Protein-derived Peptide Vaccine DSP-7888 (Amino Acid, Peptide, or Protein)\tAdenovirus HER2-Transduced Autologous Dendritic Cell Vaccine (Pharmacologic Substance)\tRETINOL-BINDING PROTEIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tmitotic DNA damage checkpoint (Genetic Function)\tUpper pole of kidney (Kidney)", + "output": "WT1 Protein-derived Peptide Vaccine DSP-7888 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as catalysis of the reaction: N(2),6-disulfo-D-glucosamine + H(2)O = N-sulfo-D-glucosamine + H(+) + sulfate.\nConcepts: toxicology registry/referral center (Intellectual Product)\tACRCTSEV (Finding)\tDevice Alarm System (Finding)\tTAT gene, function (Gene Mutation)\tN-sulfoglucosamine-6-sulfatase activity (sulfuric ester hydrolase activity)", + "output": "N-sulfoglucosamine-6-sulfatase activity (sulfuric ester hydrolase activity)" + }, + { + "input": "Definition: Molecular Function described as an adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart, where the activated adrenergic receptor transmits the signal by Gi-mediated inhibition of adenylate cyclase activity.\nConcepts: Defined Study Activity (Study Activity)\tRectum/Anus (Anus)\tGi-coupled adrenergic receptor signaling pathway involved in heart process (Molecular Function)\tregulation of transcription from RNA polymerase II promoter by a nonfermentable carbon source (carbon catabolite regulation of transcription from RNA polymerase II promoter)\tBrachial Plexus Anesthesia (Injection of upper limb)", + "output": "Gi-coupled adrenergic receptor signaling pathway involved in heart process (Molecular Function)" + }, + { + "input": "Definition: something described as surgical hooks designed to temporarily secure vasa deferentia tissues by catching and/or pulling them during dissection, excision, and/or to perform other surgical procedures with minimal trauma. These surgical hooks typically consist of handheld manual stainless steel instruments that are straight at the working end and finished in a blunt or sharp tip. The hooks typically include a handle at the proximal end. Vasectomy surgical hooks are usually small and sharp tools used to penetrate the skin of the scrotum and pull out the vas deferens so that the surgeon can sever them. They are used during surgical procedures for male sterilization and/or permanent birth control (i.e. vasectomy).\nConcepts: mandelic acid metabolism (antibiotic metabolic process)\tHooks, Surgical, Vasectomy (Medical Device)\tProliferating Erythroid/Total Cells (Blood Cell Count Ratio Measurement)\tRetinoblastoma cN0 TNM Finding v7 (Retinoblastoma Clinical Regional Lymph Nodes TNM Finding v7)\tINSS Stage 2B (International Neuroblastoma Staging System)", + "output": "Hooks, Surgical, Vasectomy (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Proxy - In the past 30 days, how much difficulty did your relative have in: His or her day-to-day work/school?\nConcepts: WD6D5 5 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)\tEosinophilic gallbladder infiltration (Eosinophilic gastroenteritis)\tregulation of microtubule disassembly (regulation of supramolecular fiber organization)\tSOWSA106 (Intellectual Product)\tchloroplast outer envelope (chloroplast membrane)", + "output": "WD6D5 5 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)" + }, + { + "input": "Definition: Cardiac Myosins described as oforms of MYOSIN TYPE II, specifically found in the ventricular muscle of the HEART. Defects in the genes encoding ventricular myosins result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.\nConcepts: Interleukin 1, Alpha wt Allele (IL1A gene)\tnucleate red blood cell differentiation (Erythropoiesis)\tlvsp (Body Part, Organ, or Organ Component)\tIsomyosins, Ventricular (Cardiac Myosins)\tCessation of Treatment (Health Care Activity)", + "output": "Isomyosins, Ventricular (Cardiac Myosins)" + }, + { + "input": "Definition: Gene or Genome described as human WWP2 wild-type allele is located in the vicinity of 16q22.1 and is approximately 179 kb in length. This allele, which encodes NEDD4-like E3 ubiquitin-protein ligase WWP2 protein, plays a role in the modulation of both protein ubiquitination and protein degradation.\nConcepts: envenomation resulting in positive regulation of argininosuccinate synthase activity in other organism (envenomation resulting in modulation of process in other organism)\tLEC0116F (LEC-5 Standard Version Questionnaire Question)\tWWp2-like (WWP2 gene)\tADCCP02 (ADAS-Cog CDISC Version Questionnaire Question)\tMUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYE ANOMALIES), TYPE A, 6 (Muscular Dystrophy)", + "output": "WWp2-like (WWP2 gene)" + }, + { + "input": "Definition: Atomic Resolution Microscopy described as indirect, molecular-resolution imaging technique in which 3- dimensional tracings of a mobile probe across the specimen's surface are processed by computer into a topological image; in contrast to STM the probe is driven only by the mechanical resistance (topology and viscoelasticity) of the surface.\nConcepts: hypertrophy; nail (non-infectious skin disorders)\tMicroscopies, Scanning Force (Microscopy)\t5 - Nodular Formation and Incomplete Cirrhosis (Intellectual Product)\tcyclic GMP binding (anion binding)\tL-idonate transmembrane transport (Cell Function)", + "output": "Microscopies, Scanning Force (Microscopy)" + }, + { + "input": "Definition: Intellectual Product described as WHO Clinical Staging of HIV/AIDS for Adults and Adolescents (Copyright World Health Organization 2007, World Health Organization. WHO case definitions of HIV for surveillance and revised clinical staging and immunological classification of HIV-related disease in adults and children; 2007. Retrieved from http://www.who.int/hiv/pub/vct/hivstaging/en/).\nConcepts: coryneform bacteria (Bacteria)\ttrailing edge membrane (cellular anatomical entity)\tWHO HIV STAGING FOR ADULTS AND ADOLESCENTS (Intellectual Product)\tMinor surgical nail procedure reference code no charge (Tracking code use with or without ICD diagnosis)\tPsacalium (Tussilagininae)", + "output": "WHO HIV STAGING FOR ADULTS AND ADOLESCENTS (Intellectual Product)" + }, + { + "input": "Definition: Classification described as dehydration is a deficiency of body water caused by inadequate intake of water or, more commonly, loss of water and sodium by the kidneys, gastrointestinal tract or skin. Water depletion may affect extracellular or intracellular volume, or both. Dehydration results from abnormal water intake (hypothalamic malfunction) or renal water wasting (diabetes insipidus). Hypernatraemia (Na > 145 mmol/l) is common. When both water and sodium are depleted, tachycardia, hypotension, and weight loss are common. Clinical findings vary based on the severity of the dehydration. In mild dehydration, the patient is alert, has capillary refill of 2 seconds or less and normal mucous membranes, tears, respirations, blood pressure, pulse and skin turgor. The eyes and fontanelles appear normal. Heart rate is slightly increased and urine output is decreased. In moderate dehydration, patients are lethargic, have capillary refill between 2 and 4 seconds, dry mucous membranes, decreased tears, increased respirations and heart rate, normal blood pressure (although orthostasis is present), thready pulse and skin turgor is slow to recover. Fontanelles can be depressed, eyes are sunken and oliguria is present. In severe dehydration, the patient is obtunded, has capillary refill over 4 seconds, cool extremities, parched or cracked mucous membranes, absent tears, increased respiratory rate, hyperpnea, tachycardia, decreased blood pressure, faint or impalpable pulse, and increased skin turgor with tenting. Fontanelles are sunken, eyes are very sunken and oliguria/anuria is present.\nConcepts: IL-17D (Interleukins)\tDioscorea villosa / wild yam (Homeopathic remedies letter D)\tDehydration (Classification)\t3-(2-Aminoethyl)-1H-indole-5,7-diol (Organic Chemical)\tmodulation by symbiont of host autophagic process (modulation by symbiont of host cellular process)", + "output": "Dehydration (Classification)" + }, + { + "input": "Definition: Finding described as a transformation of the cells of the thyroid characterized by enlarged follicular cells, apically displaced nuclei, and large intracellular vacuole with homogeneous eosinophilic content located at the base of follicular epithelial cells.\nConcepts: Beta Distribution (Quantitative Concept)\tThyroid Dysplasia (Finding)\tmanganese (Metals and elements in tox)\tEarly yaws (Cutaneous disorders of Yaws)\tWar Exposure (Occupational Exposure)", + "output": "Thyroid Dysplasia (Finding)" + }, + { + "input": "Definition: Anatomical Abnormality described as an anomaly of vein.\nConcepts: N95 Respirators (Medical Device)\tVenous abnormality (Anatomical Abnormality)\tProheparin-Binding EGF-Like Growth Factor, human (Biologically Active Substance)\tPODCI2-Comp Sports Limited by: Too Young (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tBOTTLE, PUMP (Bottle, device)", + "output": "Venous abnormality (Anatomical Abnormality)" + }, + { + "input": "Definition: Neoplastic Process described as stage I includes: (T1, N0, M0) and (T2, N0, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria.\nConcepts: regulation of tryptophan metabolism (regulation of cellular amino acid metabolic process)\tdeoxycytidyl transferase activity (Molecular Function)\tAstler-Coller A Carcinoma of Rectum (Astler-Coller A Colorectal Carcinoma)\tLEC0102A (Intellectual Product)\tAvailabilities, Biological (drug disposition)", + "output": "Astler-Coller A Carcinoma of Rectum (Astler-Coller A Colorectal Carcinoma)" + }, + { + "input": "Definition: Bone Tumor of Undefined Neoplastic Nature described as a rare benign lesion that arises from the rib cage and affects infants. It results in the formation of a mass which is composed of spindle cells, cartilage, and hemorrhagic cysts. Surgical resection is usually curative.\nConcepts: Radiologist (Medical Occupation)\tSOWSA1 (Clinical or Research Assessment Questionnaire)\tChest Wall Hamartoma (Mesenchymal hamartoma)\tVacuum-Supplemented Dental Brushes (Dental prophylaxis brush)\tMoAb M-T412 (Monoclonal Antibodies)", + "output": "Chest Wall Hamartoma (Mesenchymal hamartoma)" + }, + { + "input": "Definition: something described as a defective avian leukemia virus in the family ALPHARETROVIRUS, causing progressive anemia and weakness in domestic and wild fowl.\nConcepts: Avian Erythroblastosis Virus (Virus)\tregulation of ATP:ADP antiporter activity (Molecular Function)\tdownregulation of selenocysteine incorporation (Genetic Function)\tPROTO ONCOGENE PROTEINS C BCL 006 (Biologically Active Substance)\tSelf-Care Facilitation (Health Care Activity)", + "output": "Avian Erythroblastosis Virus (Virus)" + }, + { + "input": "Definition: Procedure related to general anesthesia described as state of total unconsciousness resulting from anesthetic drugs.\nConcepts: Intracerebral (RouteBySite)\tDichloromethanediphosphonate (Clodronate)\tD3F15S2 (Gene or Genome)\tanaesthetic general (Admin Support Interventions: Anesthesia)\tprostaglandin receptor internalization (Cell Function)", + "output": "anaesthetic general (Admin Support Interventions: Anesthesia)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as MIR506 pre-miRNA (124 bases) is encoded by the human MIR506 gene. This oligoribonucleotide may be involved in the post-transcriptional regulation of gene expression.\nConcepts: MIR506 Pre-miRNA (pre-miRNA)\tRefractory Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor (Neoplastic Process)\tBEBQ01-Baby Seems Contented Feeding (Intellectual Product)\tStroop Effect (Thesaurus of Psychological Index Terms)\tdown regulation of interleukin-6 secretion (negative regulation of interleukin-6 production)", + "output": "MIR506 Pre-miRNA (pre-miRNA)" + }, + { + "input": "Definition: Reproductive System and Breast Disorders, CTCAE described as a disorder characterized by bleeding from the prostate gland.\nConcepts: Pharmacy Library (Organization)\tregulation of long-day photoperiodism, flowering (regulation of photoperiodism, flowering)\tTransient Myocardial Ischemia of Newborn (Acute heart disease)\tProstatic Hemorrhage (Genitourinary Hemorrhage, CTCAE)\taurachin C epoxide hydrolase/isomerase activity (Molecular Function)", + "output": "Prostatic Hemorrhage (Genitourinary Hemorrhage, CTCAE)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process in which the anatomical structure of a renal artery is generated and organized. Renal arteries supply the kidneys with blood.\nConcepts: centriolar subdistal appendage (Cell Component)\trenal artery morphogenesis (Organ or Tissue Function)\tRetractors, Surgical, Urinary Tract, Prostatic (Retractors, Surgical, Urinary Tract)\tregulation of estradiol secretion (Organ or Tissue Function)\tSNHG5 LincRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "renal artery morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 5p\nConcepts: CDISC Influenza Therapeutic Area User Guide Version 1.0 (CDISC Therapeutic Area User Guide Name and Version)\t5p13 (Chromosome band)\tIVD Panels, Human Genetics, Periodic Fever Syndrome, Comprehensive (IVD Panels, Human Genetics, Periodic Fever Syndrome)\tIVD Test Reagent/Kits, Immunoassay, Protein, Transport, Transferrin (IVD Test Reagent/Kits, Immunoassay, Protein, Transport)\tStudySitePersonnel (Study Personnel)", + "output": "5p13 (Chromosome band)" + }, + { + "input": "Definition: Sodium imbalance described as an abnormally decreased sodium concentration in the urine.\nConcepts: Biocatalyst (Pharmaceutical Preparations)\textension of a leading process involved in cell motility in cerebral cortex radial glia guided migration (pseudopodium assembly)\tHyponatriuria (Abnormal urine sodium concentration)\tLuminespib Mesylate (HSP90 Inhibitor)\tregulation of ribosomal subunit transport from nucleus to cytoplasm (regulation of ribosome biogenesis)", + "output": "Hyponatriuria (Abnormal urine sodium concentration)" + }, + { + "input": "Definition: Intellectual Product described as internet Other\nConcepts: Grade 4 Vaccination complication (Finding)\tPaired Box Protein Pax-6, human (Biologically Active Substance)\tInternet Other (Intellectual Product)\timitation (Mental Process)\tantidiarrheals (gastrointestinal preparations)", + "output": "Internet Other (Intellectual Product)" + }, + { + "input": "Definition: Manufactured Object described as collection of information resources relevant to MEDICINE.\nConcepts: aromatic (S)-hydroxynitrile lyase activity (Molecular Function)\tlibrary medical (Libraries, Special)\thippocampal formation (Body Part, Organ, or Organ Component)\tLocally Advanced Pancreatic Ductal Adenocarcinoma (Neoplastic Process)\tCells, Stem (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS: GENERAL TERMS)", + "output": "library medical (Libraries, Special)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVC includes: Any T, Any N, M1. M1: Distant metastasis.\nConcepts: tricaffeoyl spermidine:S-adenosyl-L-methionine O-methyltransferase activity (O-methyltransferase activity)\tmismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication (Genetic Function)\tEicosatrienoic Acid n-3 (Eicosatrienoic Acid)\thigh-affinity hydrogen:glucose transporter activity (Molecular Function)\tStage IVC Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v7 (Thyroid Gland Anaplastic Carcinoma by AJCC v7 Stage)", + "output": "Stage IVC Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v7 (Thyroid Gland Anaplastic Carcinoma by AJCC v7 Stage)" + }, + { + "input": "Definition: something described as subcategory name for the eTMF domain containing a collection of clinical trial document templates and forms, which are not subject or investigator specific. Includes, but not limited to Protocol, Investigator Brochure, Protocol Synopsis, and Sample Case Report Form.\nConcepts: series (Modifier mainly for procedure)\tintra-aortic balloon pump (Medical Device)\tCardiobacterium hominis (Cardiobacterium)\tCore Trial Doc Subcat (Document type)\tU7 snRNP (Small Nuclear Ribonucleoproteins)", + "output": "Core Trial Doc Subcat (Document type)" + }, + { + "input": "Definition: something described as an immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This immunotoxin was conjugated through SMPT linker, which confers a slower breakdown of the toxin, and limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells.\nConcepts: Decreased circulating ACTH level (Abnormality of circulating adrenocorticotropin level)\tCYP2D6*15 Allele (Gene or Genome)\tIgG-RFB4-SMPT-dgA Immunotoxin (CD22 Immunotoxin)\tmetaphase/anaphase transition of meiosis II (metaphase/anaphase transition of meiotic cell cycle)\tAbdominal Soft Tissue Necrosis (Musculoskeletal and Connective Tissue Disorders, CTCAE)", + "output": "IgG-RFB4-SMPT-dgA Immunotoxin (CD22 Immunotoxin)" + }, + { + "input": "Definition: Pharmacologic Substance described as an extract from Mycobacterium tuberculosis (M. tuberculosis) containing the polysaccharide arabinomannan, with potential immunostimulating activity. Upon administration of M. tuberculosis arabinomannan Z-100, this agent may activate the immune system by increasing the expression of various cytokines, such as interferon-gamma (IFNg) and interleukin-12. This inhibits the activity of suppressor T-cells, increases T helper 1 cell (Th1) activity and may restore the balance between Th1/Th2 cells. Additionally, Z-100 may inhibit metastasis and tumor cell proliferation.\nConcepts: z 100 (Organic Chemical)\tPolyhydramnios and hydramnios (Hydrops of placenta)\tentamoeba histolytica (E [Preparations])\tcampest-4-en-3-one hydroxylase activity (Molecular Function)\tRadiation Source (Medical Devices)", + "output": "z 100 (Organic Chemical)" + }, + { + "input": "Definition: Neurotransmitter Agents described as drugs used for their actions on histaminergic systems. Included are drugs that act at histamine receptors, affect the life cycle of histamine, or affect the state of histaminergic cells.\nConcepts: Histaminergic Agents (Neurotransmitter Agents)\tiodo (Pharmaceutical Preparations)\tregulation of methane biosynthetic process from carbon monoxide (regulation of alkane biosynthetic process)\tConjunctival Carcinoma pT4b TNM Finding v8 (Finding)\tHMG-1 Domain (Amino Acid Sequence)", + "output": "Histaminergic Agents (Neurotransmitter Agents)" + }, + { + "input": "Definition: Premalignant Hematologic Condition described as cellular proliferation of hematopoietic cells where a substantial proportion of the cells is derived from a single hematopoietic stem cell lineage.\nConcepts: Allergic sensitization (Allergic condition)\tNon-Melanoma Surgery (Therapeutic or Preventive Procedure)\tClonal Hematopoiesis (Premalignant Hematologic Condition)\tGrade 1 Fecal incontinence (Fecal Incontinence, CTCAE 5)\tSCF-YDR131C ubiquitin ligase complex location (SCF ubiquitin ligase complex)", + "output": "Clonal Hematopoiesis (Premalignant Hematologic Condition)" + }, + { + "input": "Definition: something described as a fold change based on a concentration of a specific drug expected to produce 95% inhibition of the standard growth of a viral organism, or of a biological/biochemical reaction. It is a ratio calculated by the current IC95 Treatment Result divided by the IC95 Treatment Result from the baseline visit.\nConcepts: Monocytes.abnormal (Hematology finding abnormal)\tmesonephric glomerular basement membrane development (glomerular basement membrane development)\tNUF2, NDC80 Kinetochore Complex Component, Homolog Gene (Gene or Genome)\tIC95 Fold Change from Baseline (Laboratory or Test Result)\tviral entry into host cell via pilus retraction and membrane fusion (Cell Function)", + "output": "IC95 Fold Change from Baseline (Laboratory or Test Result)" + }, + { + "input": "Definition: Embryonal renal neoplasm described as a type of kidney tumor that is usually found before birth by ultrasound or within the first 3 months of life. It contains fibroblastic cells (connective tissue cells), and may spread to the other kidney or to nearby tissue. Congenital mesoblastic nephroma is more common in males.\nConcepts: tumor necrosis factor-related apoptosis-inducing ligand (Amino Acid, Peptide, or Protein)\tTrypsin Digestion (Protein Digestion)\tcarcinoma kidney (ADENOMAS AND ADENOCARCINOMAS)\t94 TESTES (Scrotal and testis structures)\tNephromas, Congenital Mesoblastic (Abnormality of connective tissue)", + "output": "Nephromas, Congenital Mesoblastic (Abnormality of connective tissue)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a chloride test system is a device intended to measure the level of chloride in plasma, serum, sweat, and urine. Chloride measurements are used in the diagnosis and treatment of electrolyte and metabolic disorders such as cystic fibrosis and diabetic acidosis.\nConcepts: MERCURIC THIOCYANATE, COLORIMETRY, CHLORIDE (Indicator, Reagent, or Diagnostic Aid)\ttibias (Anatomical coordinate)\tpT2 Cancer Stage Finding (after operation)\tFAQ0202 (FAQ-NACC Version Questionnaire Question)\tGreen optical filter of optical mircroscope (Component of optical microscope)", + "output": "MERCURIC THIOCYANATE, COLORIMETRY, CHLORIDE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a unit of concentration (molarity unit) equal to one picomole of substance per 10^9 cells.\nConcepts: Tudor-SN (Gene or Genome)\tMamastrovirus (Astroviridae)\tSF-36 v1.0 Acute - Question 1 (Intellectual Product)\tTrismus, CTCAE (Finding)\tpmol/10^9 cells (Molality Unit)", + "output": "pmol/10^9 cells (Molality Unit)" + }, + { + "input": "Definition: something described as an orally bioavailable dual kinase inhibitor of c-Met (hepatocyte growth factor receptor) and VEGFR-2 (vascular endothelial growth factor receptor-2) tyrosine kinases with potential antineoplastic activity. Golvatinib binds to and inhibits the activities of both c-Met and VEGFR-2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases. c-Met and VEGFR-2 are upregulated in a variety of various tumor cell types and play important roles in tumor cell growth, migration and angiogenesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82363\" active clinical trials using this agent.\nConcepts: MED Gene Panel Reagents (Medical Device)\tHanseniaspora uvarum (Niehaus) Shehata, Mrak & Phaff ex M.T. Sm., 1984 (Fungus)\t1,1-cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1-piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)- (Antineoplastic Enzyme Inhibitor)\tpositive regulation of conidiophore development (regulation of conidiophore development)\tBrock Syndrome (Atelectasis)", + "output": "1,1-cyclopropanedicarboxamide, N-(2-fluoro-4-((2-(((4-(4-methyl-1-piperazinyl)-1-piperidinyl)carbonyl)amino)-4-pyridinyl)oxy)phenyl)-N'-(4-fluorophenyl)- (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Serum, Urine and Miscellaneous Proteins described as family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands.\nConcepts: Albumen (Plasma Proteins)\tUDP-4-keto-6-deoxy-glucose-3,5-epimerase activity (racemase and epimerase activity, acting on carbohydrates and derivatives)\tArteria obturatoria (Structure of artery of pelvic region)\tChronic Maternal Hypertension (Finding)\ttime of birth (Time)", + "output": "Albumen (Plasma Proteins)" + }, + { + "input": "Definition: Thyroidectomy described as surgery involving the complete excision of the thyroid gland.\nConcepts: microtubule polymerization based protein transport (protein transport along microtubule)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 1 Intra-abdominal Pregnancy (Intellectual Product)\tB lymphoblastic leukaemia lymphoma with hypodiploidy (B Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities)\tAcantholytic Squamous Cell Carcinoma of Skin (Squamous cell carcinoma, keratinizing)\tTotal Thyroidectomy (Thyroidectomy)", + "output": "Total Thyroidectomy (Thyroidectomy)" + }, + { + "input": "Definition: something described as proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine nucleophilic attack. Serine proteases participate in a wide range of functions in the body, including blood clotting, inflammation, and digestion.\nConcepts: ADCS-ADL - Clear Dishes After Meal or Snack (Intellectual Product)\tbenzene-1,2,4-triol:oxygen 1,2-oxidoreductase (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tdamage brain (Physical & Psychosomatic Disorders)\tFiberoptic (Manufactured Object)\tSerine protease (Enzyme)", + "output": "Serine protease (Enzyme)" + }, + { + "input": "Definition: Genetic Function described as a mutation that results in an increase in a gene's activity or in acquiring a new molecular function or a new pattern of gene expression.\nConcepts: Nasal ala line (Fiat anatomical line of head)\tEnvironmental Planning (Occupational Activity)\tSUBARACHNOID (Functional Concept)\tdihydrouracil oxidase activity (oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor)\tMutations, Activation (Mutation)", + "output": "Mutations, Activation (Mutation)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the degree to which an individual feels weary right now.\nConcepts: How True Feel Weary Right Now (Intellectual Product)\tReduced circulating beta-2-microglobulin level (Finding)\tATR Kinase Inhibitor (Pharmacologic Substance)\tFractional Potassium Excretion (Laboratory or Test Result)\tprotein localisation in membrane raft (protein localization to membrane)", + "output": "How True Feel Weary Right Now (Intellectual Product)" + }, + { + "input": "Definition: Note described as a record detailing decisions and/or clarification of any information relating to the Central Trial category.\nConcepts: CYTOSINE (Pyrimidinones)\tCTrial Flnote (Note)\tGrade 3 Burn, CTCAE (Burn, CTCAE)\tDIFFER CELL (Histogenic Process)\tIDSC1-Mood Attributed to Environment (Intellectual Product)", + "output": "CTrial Flnote (Note)" + }, + { + "input": "Definition: Primary malignant neoplasm described as a non-invasive or invasive adenocarcinoma arising from a tubulovillous adenoma.\nConcepts: PODCI Adolescent Self-Reported Version - Friends Limited by: Not Around (PODCI Adolescent Self-Reported Version Questionnaire Question)\tExercisers, Flexibility, Full Body (Flexibility exerciser)\tUndefined electrical or magnetic modality narrative required (Therapeutic or Preventive Procedure)\tAdenoca in tubulovill adenoma (Malignant adenomatous neoplasm - category)\tFd (Unit of Electric Charge)", + "output": "Adenoca in tubulovill adenoma (Malignant adenomatous neoplasm - category)" + }, + { + "input": "Definition: negative regulation of olefin metabolic process described as any process that stops, prevents or reduces the frequency, rate or extent of 18-methylnonadec-1-ene metabolic process.\nConcepts: hypophysis development (gland development)\tInternational Physical Activity Questionnaire (August 2002) Short Last 7 Days Self-Administered Format Questionnaire Test Name (CDISC Questionnaire Terminology)\tRetinoblastoma pN0 TNM Finding v7 (Retinoblastoma Pathologic Regional Lymph Nodes TNM Finding v7)\tdownregulation of 18-methylnonadec-1-ene metabolic process (negative regulation of olefin metabolic process)\tWild Type RAS (Negative Test Result)", + "output": "downregulation of 18-methylnonadec-1-ene metabolic process (negative regulation of olefin metabolic process)" + }, + { + "input": "Definition: Organic Chemical described as the diphosphate ester of a synthetic, nonsteroidal form of estrogen. A well-known teratogen and carcinogen, diethylstilbestrol inhibits the hypothalamic-pituitary-gonadal axis, thereby blocking the testicular synthesis of testosterone, lowering plasma testosterone, and inducing a chemical castration.\nConcepts: interventional cardiac catheterization (cardiovascular procedures not involving operating room)\tFusobacteraeota Oren et al. 2015 (Bacterium)\tisobazzanene synthase activity (carbon-oxygen lyase activity, acting on phosphates)\tNorephedrine (Adrenergic Agents)\talpha,alpha'-diethyl-4,4'-stilbenediol diphosphate (Estrogens, Non-Steroidal)", + "output": "alpha,alpha'-diethyl-4,4'-stilbenediol diphosphate (Estrogens, Non-Steroidal)" + }, + { + "input": "Definition: Pharmacologic Substance described as a vaccine containing HER2/Neu-derived epitope (amino acids 776-790) linked to li-Key peptide (li-Key/HER2/neu hybrid peptide or AE37), and combined with granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential antineoplastic and immunoadjuvant activities. Upon vaccination, AE37 may activate the immune system and stimulate T-helper cells against HER2/Neu expressing cancer cells. GM-CSF may potentiate the immune response against cancer cells expressing the HER2/Neu antigen. The Ii-Key moiety, a 4-amino acid (LRMK) epitope from the MHC class II-associated invariant chain (Ii protein), increases T-helper cell stimulation against HER2/neu antigen when compared to unmodified class II epitopes. HER2/neu, a tumor associated antigen (TAA), is overexpressed in a variety of tumor cell types and is highly immunogenic.\nConcepts: MOKA (FBXO38 gene)\tStage I Pediatric Hodgkin's Disease (Stage I Hodgkin Lymphoma)\tAE37 Peptide/GM-CSF Vaccine (Cancer Vaccines)\tRBC count (Erythrocyte Indices)\tHeel bone (Heel)", + "output": "AE37 Peptide/GM-CSF Vaccine (Cancer Vaccines)" + }, + { + "input": "Definition: positive regulation of cell communication described as any process that increases the rate, frequency or extent of c-di-GMP signaling.\nConcepts: agonist (Mixed Agonist/Antagonist)\tClavien-Dindo Grade IIIb (Clavien-Dindo Grade III)\tRegions, Sublingual (Oral cavity)\td-amphetamine (CNS Affecting Drug Measurement)\tpositive regulation of c-di-GMP signaling (positive regulation of cell communication)", + "output": "positive regulation of c-di-GMP signaling (positive regulation of cell communication)" + }, + { + "input": "Definition: Unit of Dose Calculation described as a unit of measure expressed in milliliter(s) per animal per period of time equal to twenty-four hours.\nConcepts: Social security policies (Governmental or Regulatory Activity)\tmL/{animal}/d (Quantitative Concept)\tDelay (Priorities)\tCDC25C gene (Gene or Genome)\tarterial hypoxemia (Measurement finding below reference range)", + "output": "mL/{animal}/d (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as a type of advance directive that gives a person (such as a relative, lawyer, or friend) the authority to make healthcare decisions for another person. It becomes active when that person loses the ability to make decisions for himself or herself.\nConcepts: Competitive Medical Plan (Managed Care Programs)\tCervical Cancer pT1a1 TNM Finding v8 (Finding)\tHCP (Intellectual Product)\tSpicule (Other Anatomic Concept)\tGrade 4 Gastrointestinal stoma necrosis (Gastrointestinal Stoma Necrosis, CTCAE)", + "output": "HCP (Intellectual Product)" + }, + { + "input": "Definition: Degree findings described as the quality of nearness to the truth or the true value.\nConcepts: Absent/underdeveloped big toe (Absent toe)\t-labeled anti-EGFR affibody molecule Ac-Cys-ZEGFR:1907 (Radioconjugate)\taccurate (Property or Attribute)\tRPFNA (Diagnostic Procedure)\ttranscription initiation from bacterial-type RNA polymerase promoter (DNA-templated transcription, initiation)", + "output": "accurate (Property or Attribute)" + }, + { + "input": "Definition: Attention described as mental functions that produce concentration for the period of time required.\nConcepts: Software, Anesthetic Gas Monitoring (Computer software)\tSustained attention (Attention)\tMPPH syndrome (Multiple system malformation syndrome)\tLipase, Acylcholesterol (Esterases)\tTotal hysterectomy after cesarean delivery (Therapeutic or Preventive Procedure)", + "output": "Sustained attention (Attention)" + }, + { + "input": "Definition: something described as impaired or delayed impulse conduction between the right and left HEART ATRIA. Advanced interatrial blocks are often associated with arrhythmias (e.g., ATRIAL FLUTTER; and ATRIAL FIBRILLATION), direct conduction block via the Bachmann's bundle and concomitant left atrial enlargement. Syndrome of advanced interatrial block associated with SUPRAVENTRICULAR TACHYCARDIA is referred to as Bayes syndrome.\nConcepts: Internal obturator muscle structure (Body Part, Organ, or Organ Component)\tbehavioral response to food (Behavior)\tI regret having the bone marrow transplant (Findings-Based Question)\thUBA3 (Gene or Genome)\tInteratrial Conduction Delay (Disease or Syndrome)", + "output": "Interatrial Conduction Delay (Disease or Syndrome)" + }, + { + "input": "Definition: Gastrointestinal Disorders, CTCAE described as a disorder characterized by a sensation of marked discomfort in the mouth, tongue or lips.\nConcepts: C-SSRS Baseline/Screening Version - Description of Interrupted Suicide Attempt (C-SSRS Baseline/Screening Version Questionnaire Question)\tSubstance, Humic (Biologically Active Substance)\tSyringe/Needle Destroyers (Reusable Devices)\tpositive regulation of cytokine activity (positive regulation of signal transduction)\tOral pain (Finding)", + "output": "Oral pain (Finding)" + }, + { + "input": "Definition: Hereditary Motor and Sensory Neuropathies described as spastic paraplegia that is transmitted from parent to child.\nConcepts: CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIb (Autosomal recessive hereditary disorder)\tparaplegia; spastic, hereditary (Spinocerebellar Degeneration)\tSTIMULATOR, MUSCLE, DIAGNOSTIC (Medical Device)\tMendelian susceptibility to mycobacterial disease due to complete ISG15 deficiency (Autosomal recessive hereditary disorder)\tNeptune (Geographic Area)", + "output": "paraplegia; spastic, hereditary (Spinocerebellar Degeneration)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as peptides with covalently attached carbohydrate, usually resulting from biodegradation or laboratory hydrolysis of glycoproteins.\nConcepts: Neoaortic valve regurgitation (Disease or Syndrome)\tStability Study Data File Type Terminology (FDA Stability Data Standards Terminology)\tent-cassadiene C11alpha-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tInterleukin-2 Jurkat Derived (Pharmacologic Substance)\tGlycopeptide (Amino Acid, Peptide, or Protein)", + "output": "Glycopeptide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Necrosis NEC described as relating to or affected by necrosis.\nConcepts: Health professionals (Education/welfare/health profession)\tcounseling (Procedure by method)\tNecroses (Physical findings)\tRas-Related Protein Rab-5C (Amino Acid, Peptide, or Protein)\tBegomoviruses (Geminiviridae)", + "output": "Necroses (Physical findings)" + }, + { + "input": "Definition: something described as intrahepatic bile duct cancer with distant metastasis.\nConcepts: 2-carene synthase activity (carbon-oxygen lyase activity, acting on phosphates)\tViral Hemagglutination (Virus Physiological Processes)\tNPI1L11 (NPI Questionnaire Question)\tIntrahepatic Bile Duct Cancer cM1 TNM Finding v7 (Finding)\tperque l-methionine glycine (Pharmacologic Substance)", + "output": "Intrahepatic Bile Duct Cancer cM1 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as skeletal ligament. each instance of which connects some tooth to some maxilla or mandible\nConcepts: (+)-neomenthol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tPop Culture (Anthropological Culture)\txylem histogenesis (phloem or xylem histogenesis)\tPeriodontal membrane (Tooth Components)\tdown-regulation of reactive oxygen species formation (Molecular Function)", + "output": "Periodontal membrane (Tooth Components)" + }, + { + "input": "Definition: Group ID described as a character or string that represents a cardiovascular system findings group.\nConcepts: T-Cell Receptor, alpha-beta (T-cell receptor marker)\tCVGRPID (Intellectual Product)\tMicrosatellite Instability Positive (gene mutation-related cancer)\tCatarrhs, Nasal (Upper respiratory tract infections NEC)\tCXXC-Type Zinc Finger Protein 2 (Amino Acid, Peptide, or Protein)", + "output": "CVGRPID (Intellectual Product)" + }, + { + "input": "Definition: Completion Status described as a term used to describe the state or condition of the completeness of the drug accountability data.\nConcepts: Cardiomyopathy due to diabetes mellitus (Diabetes Mellitus)\tNimodipine product (Dihydropyridine derivative)\tregulation of cyclodextrin metabolic process (Cell Function)\tHow Much Time Did it Take (Intellectual Product)\tDrug Accountability Completion Status (Completion Status)", + "output": "Drug Accountability Completion Status (Completion Status)" + }, + { + "input": "Definition: Virus described as a genus of single-stranded, positive-sense RNA viruses in the family coronaviridae. The coronavirus genome exhibits helical symmetry.\nConcepts: myoblast proliferation involved in skeletal muscle regeneration (Cell Function)\tBranch Chief (Professional or Occupational Group)\tubidecarenone nanodispersion BPM31510 (Antineoplastic Agents)\tNeuropsychologies (Biomedical Occupation or Discipline)\t335 CORONAVIRUS (Virus)", + "output": "335 CORONAVIRUS (Virus)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process whose specific outcome is the development of the umbilical cord, from its formation to the mature structure. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.\nConcepts: umbilical cord development (anatomical structure development)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Coccidioides immitis, IgA Antibody (Medical Device)\tSkin care treatments and procedures (TISSUE INTEGRITY COMPONENT)\tDisenfranchised Grief (Mental Process)\tAnterodorsal nucleus (Thalamic Nuclei)", + "output": "umbilical cord development (anatomical structure development)" + }, + { + "input": "Definition: something described as physical location of CXCL2_Gene\nConcepts: 4: 75329947-75327791 (Spatial Concept)\tBowel habits (Gastrointestinal system)\tGrade 2 Anorectal infection (Finding)\tpharmaceutical product (Pharmacologic Substance)\tCadmium measurement (Chemical procedure)", + "output": "4: 75329947-75327791 (Spatial Concept)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase.\nConcepts: ARQ 761 (Pharmacologic Substance)\tBRAF Mutation Analysis Was Not Performed (Mutation Analysis Was Not Performed)\tANTISERUM, PSEUDOMONAS PSEUDOMALLEI (Indicator, Reagent, or Diagnostic Aid)\tPKRL (Gene or Genome)\tDNA replication licensing (regulation of DNA metabolic process)", + "output": "DNA replication licensing (regulation of DNA metabolic process)" + }, + { + "input": "Definition: Antioxidants described as a class of natural flavonoids derived from the dried leaves of the plant Camellia sinensis (tea) and related plants with potent antioxidant properties. Theaflavins are polymers derived from natural catechins which are oxidized upon drying of the plant leaf. Flavonoids such as theaflavins neutralize free-radical species and increase the activity of detoxifying phase II enzymes in the liver. In animal studies, theaflavins have been shown to exhibit antitumor effects by inducing tumor cell apoptosis, arresting cell division, inhibiting cancer cell invasion, and blocking growth factor-induced angiogenesis. Black tea contains the highest concentrations of theaflavins.\nConcepts: ADTC01-How Often Drink Alcohol (AUDIT-C Questionnaire Question)\tregulation (Biological Processes)\tTheaflavine (Antioxidants)\tparotids (Cheek structure)\tDeleterious BARD-1 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Theaflavine (Antioxidants)" + }, + { + "input": "Definition: Postoperative shock described as a state of shock following a surgical operation.\nConcepts: Treatment Related Acute Myeloid Leukemia (Therapy-related acute myeloid leukemia and myelodysplastic syndrome)\tTetraethylammonium Ion (Organic Chemical)\tUnraveled Material (Finding)\tneuron process extension (developmental growth involved in morphogenesis)\t(Postoperative shock) or (collapse - postoperative NOS) (Shock, Surgical)", + "output": "(Postoperative shock) or (collapse - postoperative NOS) (Shock, Surgical)" + }, + { + "input": "Definition: something described as human ACE2 wild-type allele is located in the vicinity of Xp22 and is approximately 41 kb in length. This allele, which encodes angiotensin-converting enzyme 2 protein, is involved in both peptide hormone-processing and vasodilation.\nConcepts: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process (benzene-containing compound metabolic process)\tdown-regulation of intracellular sterol transport (regulation of intracellular sterol transport)\tSoutheastern States (Geographic Area)\tadenovirus 5-tumor necrosis factor alpha (Pharmacologic Substance)\tACEH (Gene or Genome)", + "output": "ACEH (Gene or Genome)" + }, + { + "input": "Definition: something described as neuregulin-1 (222 aa, ~24 kDa) is encoded by the human NRG1 gene. This protein is involved in binding to receptors from the EGF receptor family of protein tyrosine kinases.\nConcepts: C2 BLOOD (Blood, Heart and Circulation)\tcapillaria philippinensis (Superfamily Trichinelloidea)\tC-type Lectin Domain Family 4, Member C wt Allele (Gene or Genome)\tStenosis of artery (Abnormal systemic arterial morphology)\tARIA protein, human (Amino Acid, Peptide, or Protein)", + "output": "ARIA protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Malignant Neoplasms described as a primary or metastatic malignant neoplasm that affects the hard palate.\nConcepts: FACT-B Version 4 - I Am Able to Work (Intellectual Product)\tMATRIX METALLOPROTEINASE 8 (Metallopeptidase Gene)\tArea 30 of Mauss (Body Part, Organ, or Organ Component)\tMalignant Hard Palate Neoplasm (Neoplasm of hard palate)\tStage IIB Lung Adenosquamous Carcinoma AJCC v7 (Stage IIB Non-Small Cell Lung Carcinoma AJCC v7)", + "output": "Malignant Hard Palate Neoplasm (Neoplasm of hard palate)" + }, + { + "input": "Definition: something described as a regimen consisting of docetaxel and prednisone used for the treatment of metastatic hormone-refractory prostate cancer.\nConcepts: Grade 3 Delirium, CTCAE (Finding)\tplacenta abnormalities (CONGENITAL ANOMALIES OF THE FETUS AND AFTERBIRTH)\tdocetaxel/prednisone (Regimen Used to Treat Prostate Carcinoma)\tStage IB Mycosis Fungoides and Sezary Syndrome AJCC v8 (Neoplastic Process)\tRhabdomyosarcoma Group IIIb (Intergroup Rhabdomyosarcoma Clinical Group Extent of Disease)", + "output": "docetaxel/prednisone (Regimen Used to Treat Prostate Carcinoma)" + }, + { + "input": "Definition: Cytokine Measurement described as the determination of the amount of interleukin 5 present in a sample.\nConcepts: Interleukin 5 Measurement (Cytokine Measurement)\tFLUOROCYTOSINE 05 (Antibiotics)\tMAPK4 wt Allele (MAPK4 gene)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, HER2/NEU (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tCaribbean Indian (Racial group)", + "output": "Interleukin 5 Measurement (Cytokine Measurement)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Miliary TB (Korean Standard Classification of Disease Version 5)\tSuperior Intercostal Vein (Veins)\tMIR433 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tLymphocyte-Activation Gene 3 (Gene or Genome)\tQS-PARENT-DDS TEST (Intellectual Product)", + "output": "QS-PARENT-DDS TEST (Intellectual Product)" + }, + { + "input": "Definition: Menu: Laboratory described as WHAT: Synovial fluid, abnormal.\nConcepts: Express Gene Microarrays (Molecular Microarrays)\tAschoff-Tawara node (root)\tAutologous LMP1-/LMP2- Specific Cytotoxic T-Lymphocytes (Cell)\tSynovial or cerebrospinal fluid examination (Diagnostic Procedure)\tpurine deoxyribonucleoside triphosphate synthesis (deoxyribonucleoside triphosphate biosynthetic process)", + "output": "Synovial or cerebrospinal fluid examination (Diagnostic Procedure)" + }, + { + "input": "Definition: Organism Function described as positive regulation of a B cell mediated immune response mediated via cytokine production by a helper T cell.\nConcepts: DEVICES, MEASURE, ANTIBODIES TO GLOMERULAR BASEMENT MEMBRANE (Medical Device)\tHas intent (Concept model object attribute)\thelper T cell enhancement of B cell mediated immune response (helper T cell enhancement of adaptive immune response)\tlung saccule development (anatomical structure development)\tNeoplastic Plasma Cells More than 20 Percent of Bone Marrow Nucleated Cells (Laboratory or Test Result)", + "output": "helper T cell enhancement of B cell mediated immune response (helper T cell enhancement of adaptive immune response)" + }, + { + "input": "Definition: something described as this gene is involved in signal transduction and negative regulation of synaptic transmission.\nConcepts: transducin beta chain 1 (Heterotrimeric G Protein Subunit Gene)\tClinical Governance (Health Care Activity)\tLipoma of the Epicardium (Cardiac Lipoma)\tauditory feedback (Mental Process)\tType-1 Polarized DC-induced Antigen-specific Autologous CTLs (therapeutic autologous lymphocytes)", + "output": "transducin beta chain 1 (Heterotrimeric G Protein Subunit Gene)" + }, + { + "input": "Definition: Disorder of toe described as webbing or fusion of the toes, involving soft parts only or including bone structure. Bony fusions are referred to as bony\" Syndactyly if the fusion occurs in a radio-ulnar axis. Fusions of bones of the toes in a proximo-distal axis are referred to as \"Symphalangism\".\"\nConcepts: Advanced Gastroenteropancreatic Neuroendocrine Neoplasm (Advanced Neuroendocrine Neoplasm)\talbright's syndrome (Hamartosis, NOS)\tPainting, Interior or Exterior (Intellectual Product)\tBevacizumab-Cyclophosphamide (Regimen Used to Treat Malignant Peritoneal Neoplasm)\tsyndactyly; toes (Congenital Abnormality)", + "output": "syndactyly; toes (Congenital Abnormality)" + }, + { + "input": "Definition: Finding described as an abnormal magnetic resonance tomography signal from a vertebral endplate with a high signal on T1-weighted sequences and high- or isointense signal on T2 sequences. Modic type II signals are thought to indicate fatty replacement in the bone marrow.\nConcepts: MSQL1-Others Notice Your Memory Trouble (MSQOL-54 Questionnaire Question)\themoglobin subunit zeta (Globin Gene)\tCompression dressing (Bandage)\tModic type II vertebral endplate changes (Finding)\tperception of BLP (detection of molecule of bacterial origin)", + "output": "Modic type II vertebral endplate changes (Finding)" + }, + { + "input": "Definition: response to anesthetic described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.\nConcepts: Necrotizing angiitis (Necrosis of artery)\tRegulator Device (Device Component or Accessory)\tresponse to cocaine (response to organic cyclic compound)\tOrthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic (Medical Device)\tHyperautofluorescent retinal lesion (Abnormal fundus autofluorescence imaging)", + "output": "response to cocaine (response to organic cyclic compound)" + }, + { + "input": "Definition: protein-containing complex described as a protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3.\nConcepts: TBK1-IKBKE-DDX3 complex (Cell Component)\tUTP23 wt Allele (Gene or Genome)\tTendonitis NOS (Acute inflammatory disease)\tnmol/L/(ug/m2/d) (Quantitative Concept)\texodeoxyribonuclease activity, producing 5'-phosphomonoesters (exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters)", + "output": "TBK1-IKBKE-DDX3 complex (Cell Component)" + }, + { + "input": "Definition: Personal Health Issues described as degree to which individuals have the capacity to obtain, process, and understand basic health information and services needed to make appropriate health decisions.\nConcepts: viral DNA genome packaging (Viral Genome Packaging)\tAnthracosilicoses (Pneumoconiosis)\tFRS (sulfonamides, high-ceiling diuretics, plain)\tLEM Domain Containing 3 Gene (Gene or Genome)\tLiteracy, Health (Mental Process)", + "output": "Literacy, Health (Mental Process)" + }, + { + "input": "Definition: Medical Device described as surgical apparel are devices that are intended to be worn by operating room personnel during surgical procedures to protect both the surgical patient and the operating room personnel from transfer of microorganisms, body fluids, and particulate material. Examples include surgical caps, hoods, masks, gowns, operating room shoes and shoe covers, and isolation masks and gowns. Surgical suits and dresses, commonly known as scrub suits, are excluded.\nConcepts: malonate (Dicarboxylate)\tAPOE (Lipoprotein and lipid tests NEC)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, AIRE (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tphosphofurin acidic cluster sorting protein 1, human (Biologically Active Substance)\tCOVER, SHOE, OPERATING-ROOM (Medical Device)", + "output": "COVER, SHOE, OPERATING-ROOM (Medical Device)" + }, + { + "input": "Definition: niacinamide described as b complex vitamin used in the prophylaxis and treatment of pellagra; functions as a component of the coenzyme NAD (Nicotinamide-Adenine Dinucleotide).\nConcepts: up regulation of peptide antigen transport (regulation of peptide antigen transport)\tSquamous Transitional Epithelial Cell Count (Urine Sediment Analysis Measurement)\tHAQ0219 (HAQ-DI Without VAS Questionnaire Question)\taxonemal microtubule depolymerization (cilium disassembly)\tNIACINAMIDE (Vitamins - tox)", + "output": "NIACINAMIDE (Vitamins - tox)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures of the salivary gland are generated and organized.\nConcepts: SVUPDES (Intellectual Product)\tBody, Apoptotic (Extracellular Vesicles)\tAlgorithm Code (Intellectual Product)\tsalivary gland morphogenesis (Organ or Tissue Function)\tgamma-tubulin large complex (gamma-tubulin complex)", + "output": "salivary gland morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a single layer of specialized, flat, mitochondria-rich cells that line the posterior surface of the cornea, which govern fluid and solute transport across the posterior surface of the cornea.\nConcepts: Nuclear Protein in Testis Midline Carcinoma (Neoplasms malignant site unspecified NEC)\tCAPSULE, IMMEDIATE RELEASE (capsule)\tLack of Appetite Score 8 (Lack of Appetite Visual Analogue Scale)\tAngular Pregnancies (reproductive system disorder)\tCORNEAL ENDOTHELIUM (Body tissue)", + "output": "CORNEAL ENDOTHELIUM (Body tissue)" + }, + { + "input": "Definition: something described as a finding indicating that a subject has one or more measurable pathological lesions.\nConcepts: Outcome Measure Type (ObservationMeasureType)\tWarming Units, Patient, Conductive Layer, Infant (Medical Device)\tVideotelephony (Educational Activities)\tHepatopulmonary Syndrome (Other diseases of liver)\tMeasurable Disease (Disease or Syndrome)", + "output": "Measurable Disease (Disease or Syndrome)" + }, + { + "input": "Definition: Pongo described as a species of orangutan, family HOMINIDAE, found in the forests on the island of Sumatra.\nConcepts: SUV39H (Gene or Genome)\tI have breast sensitivity/tenderness (Findings-Based Question)\tprimary amino compound biosynthetic process (organonitrogen compound biosynthetic process)\tOrangutan, Sumatran (Pongo)\tBone dysplasia lethal Holmgren type (Disease or Syndrome)", + "output": "Orangutan, Sumatran (Pongo)" + }, + { + "input": "Definition: Disorder of oral soft tissues described as bleeding originating from the mouth.\nConcepts: CARBOFURAN (Organic Chemical)\tbleeding in mouth (Oral cavity finding)\tStage III Testicular Nonseminomatous Germ Cell Tumor (Stage III Testicular Cancer AJCC v6 and v7)\tForce-sensitive Electronic Probe (Conceptual Entity)\t2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid (Organic Chemical)", + "output": "bleeding in mouth (Oral cavity finding)" + }, + { + "input": "Definition: clathrin-dependent endocytosis described as clathrin-dependent endocytosis of presynaptic membrane regions comprising synaptic vesicles' membrane constituents. This is a relatively slow process occurring in the range of tens of seconds.\nConcepts: Infection, Togaviridae (Togaviridae Infections)\tclathrin-dependent synaptic vesicle endocytosis (Intracellular Transport)\tRhabdomyosarcoma of cervix uteri (Rhabdomyosarcoma)\tMedication for Rheumatic Fever (Therapeutic or Preventive Procedure)\tUrinary Casts (Biospecimen)", + "output": "clathrin-dependent synaptic vesicle endocytosis (Intracellular Transport)" + }, + { + "input": "Definition: Mitochondrial ADP, ATP Translocases described as a subtype of mitochondrial ADP, ATP translocase found primarily in FIBROBLASTS.\nConcepts: Has No Sibling (Other Finding)\tmyristyl nicotinate cream (Clinical Drug)\tANT-2 Transport Protein (Biologically Active Substance)\tAbnormal renal corticomedullary differentiation (Abnormal renal cortex morphology)\tAir compressor, device (Devices)", + "output": "ANT-2 Transport Protein (Biologically Active Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a recombinant form of the naturally occurring human pancreatic hormone insulin. Upon administration, regular insulin mimics the action of endogenous human insulin and binds to insulin receptors located on muscle and fat cells. This both facilitates the cellular uptake of glucose and lowers blood glucose levels. In addition, insulin inhibits the liver's conversion of stored glycogen into glucose, which also decreases blood glucose levels. Insulin also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C29125\" active clinical trials using this agent.\nConcepts: NR1D1 wt Allele (NR1D1 gene)\tmyocardial epithelial involution involved in heart jogging (morphogenesis of an epithelial fold)\tinsulin regular, human (Insulin [EPC])\tMetformin HCl (Antidiabetics)\tUterine Hemorrhages (Female Reproductive System Disorder)", + "output": "insulin regular, human (Insulin [EPC])" + }, + { + "input": "Definition: Malignant musculoskeletal and connective tissue neoplasms described as the reemergence of epithelioid sarcoma after a period of remission\nConcepts: Capitate-Hamate Joint (Body Space or Junction)\tStructure of lunula (Nail plate)\tZymomonas group (Sphingomonadales)\tEnglish Plantain Pollen IgE (Laboratory Procedure)\tEpithelioid Sarcoma, Recurrent (Neoplastic Process)", + "output": "Epithelioid Sarcoma, Recurrent (Neoplastic Process)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as edinburgh Postnatal Depression Scale test code.\nConcepts: CDISC Questionnaire EPDS Test Code Terminology (Intellectual Product)\tbiopsy muscle (Operation on skeletal muscle)\tKANAMYCIN A (Antibiotic)\tSurgical Instrument Pouches (Device Labeled for Single Use)\tDiplegias, Spastic (Spastic cerebral palsy)", + "output": "CDISC Questionnaire EPDS Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: something described as a retinal condition of very immature infants that may be characterized by non-vascularized retina that may lead to neovascularization, scarring, retinal detachment, and blindness.\nConcepts: Occlusion, Cerebrovascular (Cerebrovascular Disorders)\tCerebellar Purkinje layer atrophy (Anatomical Abnormality)\tcolumnar/cuboidal epithelial cell differentiation (Cell Function)\tMajor Salivary Gland Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Major Salivary Gland Cancer Pathologic TNM Finding v7)\tRetinopathy of Prematurity, Adverse Event (Finding)", + "output": "Retinopathy of Prematurity, Adverse Event (Finding)" + }, + { + "input": "Definition: Embryonic Structure described as an early stage in the development of the embryo that follows the blastocyst stage, during which the three germ layers, ectoderm, mesoderm, and endoderm are formed by the process of gastrulation.\nConcepts: DRD2 1 Allele (DRD2 gene)\tGastrulas (Embryo)\tSeminin (Antigens)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PHOX2B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tGrade 3 Chest Wall Pain, CTCAE (Finding)", + "output": "Gastrulas (Embryo)" + }, + { + "input": "Definition: Genus: Coronavirus described as a species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).\nConcepts: Pteroylmonoglutamic acid (Vitamin)\tMMS1-What Is the City/Town (MMSE Functional Test Question)\tMaximum Concentration of Unbound Drug (Cmax)\tSquatting (Physiologic Function)\tmurine hepatitis virus (Hepatitis Viruses)", + "output": "murine hepatitis virus (Hepatitis Viruses)" + }, + { + "input": "Definition: Peripheral Nerve Injuries described as traumatic injuries to the OCULOMOTOR NERVE. This may result in various eye movement dysfunction.\nConcepts: Third Nerve Trauma (Oculomotor Nerve Paralysis)\tFOSI - I Have Nausea (FOSI Questionnaire Question)\tallantoin:proton symporter activity (amide transmembrane transporter activity)\tRhizomelic syndrome Urbach type (Disease or Syndrome)\tcytoplasmic chromatin (Chromatin)", + "output": "Third Nerve Trauma (Oculomotor Nerve Paralysis)" + }, + { + "input": "Definition: Anatomy Qualifier described as the chambers of the heart, to which the BLOOD returns from the circulation.\nConcepts: VASCULITIS CEREBRAL (Inflammatory disorder of the cardiovascular system)\tNematocysts (Animal Structures)\tovarian development (Organ or Tissue Function)\theart atria (Body part)\tQIDSR1-Decreased Appetite (Intellectual Product)", + "output": "heart atria (Body part)" + }, + { + "input": "Definition: something described as an autosomal dominant condition caused by mutation(s) in the CAV3 gene, encoding caveolin-3. It is characterized by mechanically triggered contractions of skeletal muscles. Limb-girdle muscular dystrophy type 1C is an allelic disorder with an overlapping phenotype.\nConcepts: Service Delivery Location (Location)\tHPV-66 (human papillomavirus)\tanti-CD166-DM4 CX-2009 (Immunologic Factor)\tLGMD1C, FORMERLY (Disease or Syndrome)\t2: 206849840-206853158 (Spatial Concept)", + "output": "LGMD1C, FORMERLY (Disease or Syndrome)" + }, + { + "input": "Definition: Quantitative Concept described as an arbitrary unit of substance rate expressed in unit(s) per kilogram per period of time equal to sixty minutes.\nConcepts: Dosage Formation, Die Cutting (Laboratory Procedure)\t{Unit}/kg/h (Units per unit mass per unit time)\tabstracting and indexing (Occupational Activity)\tBlood Disorder Gene Panel Reagents (Medical Device)\tPressures, Subarachnoid (Neurological status)", + "output": "{Unit}/kg/h (Units per unit mass per unit time)" + }, + { + "input": "Definition: something described as a systematic collection of factual data pertaining to dental or oral health and disease in a human population within a given geographic area.\nConcepts: Juvenile onset Huntington's disease (Huntington Disease)\tChromint Program (Computer software)\tDental Health Survey (Research Activity)\tIMD54 (Immunologic Deficiency Syndromes)\tIVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy, Limb-Girdle (Medical Device)", + "output": "Dental Health Survey (Research Activity)" + }, + { + "input": "Definition: something described as insurance providing coverage for dental care.\nConcepts: Insurance, Dental (Health Insurance)\tChief Cells (Specialized epithelial cell)\tLearning Curve (Learning)\tInformation Systems (Informatics)\tPressure Plethysmographs (Medical Device)", + "output": "Insurance, Dental (Health Insurance)" + }, + { + "input": "Definition: somatic recombination of immunoglobulin gene segments described as the process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor.\nConcepts: Schistosoma Hematobium-Related Bladder Verrucous Carcinoma (verrucous carcinoma of bladder)\tB lymphocyte receptor editing (Genetic Function)\tExtensive Stage Small Cell Carcinoma of the Lung (Small cell carcinoma of lung)\tGrade 3 Infant Sedation, AE (Infant Sedation, Adverse Event)\tMismatch Information (UML Entity)", + "output": "B lymphocyte receptor editing (Genetic Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48409\" active clinical trials using this agent.\nConcepts: RAV12 (Monoclonal Antibodies)\tParainfluenza Virus 4, Human (Virus)\tregulation of inositol biosynthesis (regulation of alcohol biosynthetic process)\tAcute haemorrhagic oedema of infancy (Disease or Syndrome)\tNon-Metastatic Prostate Carcinoma (Neoplastic Process)", + "output": "RAV12 (Monoclonal Antibodies)" + }, + { + "input": "Definition: ADAS-Cog CDISC Version Questionnaire Question described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Delayed word recall task for word 7.\nConcepts: E39 Peptide Vaccine (Immunologic Factor)\tNolvadex Regimen (Therapeutic or Preventive Procedure)\tDelayed Word Recall: Word [7] (Intellectual Product)\tSITTING, LEGS DEPENDENT (Body position)\tConvalescent Hospitals (Health Care Related Organization)", + "output": "Delayed Word Recall: Word [7] (Intellectual Product)" + }, + { + "input": "Definition: Chemo/immuno/hormone Therapy Regimen described as any regimen that can be used for the treatment of malignant mesothelioma.\nConcepts: ADAM Metallopeptidase Domain 8 Measurement (Protein or Enzyme Type Measurement)\tRegimen Used to Treat Malignant Mesothelioma (Therapeutic or Preventive Procedure)\tDevice Difficult to Operate (Device Evaluation Result)\tresponse to interferon-lambda (response to cytokine)\tSyphilis, NOS (Spirochaetales Infections)", + "output": "Regimen Used to Treat Malignant Mesothelioma (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a disorder characterized by impaired gas exchange by the respiratory system resulting in hypoxia and a decrease in oxygenation of the tissues that may be associated with an increase in arterial levels of carbon dioxide.\nConcepts: epicardium-derived cardiac fibroblast cell differentiation (cardiac fibroblast cell differentiation)\tTiter Trays (Medical Device)\tRespiratory Failure (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tRelevantRegulation (Intellectual Product)\tDNA Modification (DNA metabolic process)", + "output": "Respiratory Failure (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVA includes: (Any T, Any N, M1a); (Any T, Any N, M1b). M1a: Tumor with separate tumor nodule(s) in a contralateral lobe; tumor with pleural or pericardial nodules or malignant pleural or pericardial effusion. Most pleural (pericardial) effusions with lung cancer are a result of the tumor. In a few patients, however, multiple microscopic examinations of pleural (pericardial) fluid are negative for tumor, and the fluid is nonbloody and not an exudate. If these elements and clinical judgment dictate that the effusion is not related to the tumor, the effusion should be excluded as a staging descriptor. M1b: Tumor with single extrathoracic metastasis in a single organ (including involvement of a single nonregional node). (AJCC 8th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C136483\" active clinical trials using this agent.\nConcepts: Stage IVA Lung Cancer (Neoplastic Process)\tPleomorphic Adenoma of the Soft Palate (Oral Cavity Pleomorphic Adenoma)\tKilogram/litre (Mass concentration)\tGrade 1 Fatigue, CTCAE (Fatigue, CTCAE 5.0)\tChildhood Nasal Type Extranodal NK/T-Cell Lymphoma (Nasal Type Extranodal NK/T-Cell Lymphoma)", + "output": "Stage IVA Lung Cancer (Neoplastic Process)" + }, + { + "input": "Definition: Structure of cardiac valve cusp described as leaflet of tricuspid valve which is attached to the anterior and septal papillary muscles through the chorda tendinea of right ventricle.\nConcepts: Sulfate Proteoglycans, Heparan (Biologically Active Substance)\tAnterosuperior tricuspid leaflet (Structure of leaflet of tricuspid valve)\tstage II small intestinal adenocarcinoma AJCC v8 (Small Intestinal Adenocarcinoma by AJCC v8 Stage)\tUIQ - Upper inner quad breast (Breast quadrant)\tpositive regulation of mammary placode formation by mesenchymal-epithelial signaling (positive regulation of animal organ morphogenesis)", + "output": "Anterosuperior tricuspid leaflet (Structure of leaflet of tricuspid valve)" + }, + { + "input": "Definition: something described as human PIP4K2A wild-type allele is located in the vicinity of 10p12.2 and is approximately 178 kb in length. This allele, which encodes phosphatidylinositol 5-phosphate 4-kinase type-2 alpha protein, is involved in the formation of phosphatidylinositol-4,5-biphosphate, the precursor to second messengers of phosphoinositide signal transduction pathways.\nConcepts: PIP4K2A wt Allele (PIP4K2A gene)\tSMDDS Version 1.0 - How Much Feel Not Worth Living (SMDDS Version 1.0 Questionnaire Question)\tPARENT (status by family relationship)\thigh-affinity thiamin:hydrogen symporter activity (thiamine:proton symporter activity)\tInfection precautions treatments and procedures (rnrx physical regulation)", + "output": "PIP4K2A wt Allele (PIP4K2A gene)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a colostrum immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the specific proteins in colostrum. Colostrum is a substance excreted by the mammary glands during pregnancy and until production of breast milk begins 1 to 5 days after childbirth.\nConcepts: DROXIDOPA (norepinephrine)\tcardiac glycoside aglycone (steroid glycoside aglycone)\tphosphatidylserine exposure on osteoblast involved in bone mineralization (plasma membrane phospholipid scrambling)\tSpinal reticular formation (Body Part, Organ, or Organ Component)\tCOLOSTRUM, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "COLOSTRUM, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as assessment of the functioning of health care employee in relation to work.\nConcepts: MIR26A2 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tQiagen HPV Lab Test (Laboratory Procedure)\tContinuous Thread Metal Container Closure (Container Closure System)\tinterleukin-17-mediated signalling pathway (cytokine-mediated signaling pathway)\thealth care personnel performance (Behavior)", + "output": "health care personnel performance (Behavior)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the glyoxylate and hydroxypyruvate reductase (GRHPR) gene, located at chromosome 9p13.2, which encodes the protein glyoxylate reductase/hydroxypyruvate reductase. Genetic variants at this locus have been associated with primary hyperoxaluria type II.\nConcepts: Genital itching/irritation (Intellectual Product)\tWilms' tumor and other childhood kidney tumors (Kidney Neoplasm)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GRHPR (Medical Device)\tAmpulla of Vater Clear Cell Adenocarcinoma (Neoplastic Process)\tmandrake (Organic Chemical)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GRHPR (Medical Device)" + }, + { + "input": "Definition: Study Personnel described as a person at the primary location of research that retains the responsibility for regulation compliance and ensures the proper administration of the objectives, study design, and methodology of study.\nConcepts: Open previously opened jars (Clinical or Research Assessment Question)\tProtocol Chair (Study Personnel)\tOdontometry (Diagnostic Procedure)\tSTX11 Gene (Trafficking Protein Gene)\tPDGFR Family Protein Overexpression (Protein Deregulation)", + "output": "Protocol Chair (Study Personnel)" + }, + { + "input": "Definition: Organic Chemical described as a thiosemicarbazone prodrug with antitubercular activity. Although the exact mechanism by which thioacetazone exerts its effect has yet to be fully elucidated, this agent, upon activation by bacterial monooxygenase EtaA, appears to target and inhibit cyclopropane mycolic acid synthases (CMASs), a family of S-adenosyl-methionine-dependent methyl transferases responsible for cyclopropanation of mycolic acid. By inhibiting mycolic acid synthesis, the bacterial cell wall becomes more permeable and less resistant to injury which eventually leads to cell lysis. Mycolic acids, long-chain fatty acids, are essential mycobacterial cell wall components and play a key role in resistance to cell injury and mycobacterial virulence.\nConcepts: beta Erythroidine, Dihydro (Heterocyclic Compounds, 4 or More Rings)\tthiacetazone (Pharmacologic Substance)\tPrenatal consultation each 15 minutes (Prenatal care)\tI don't look like myself (Intellectual Product)\tAlcohol, Dodecyl (D [Preparations])", + "output": "thiacetazone (Pharmacologic Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.\nConcepts: CONCENTRATED (Biospecimen Condition)\tCD86 biosynthesis (Molecular Function)\tWINGLESS-TYPE MMTV INTEGRATION SITE FAMILY, MEMBER 4 (WNT Family Gene)\tPhosphotransferases (Phosphotransferases)\tEPIC-CP - Quality of Erections (Intellectual Product)", + "output": "Phosphotransferases (Phosphotransferases)" + }, + { + "input": "Definition: Stage II Fallopian Tube Cancer described as stage IIA includes: T2a, N0, M0. T2a: Extension and/or metastasis to the uterus and/or ovaries. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: response to wounding (Organism Function)\tprimary cell-wall cellulose synthase complex location (cellulose synthase complex)\tC-SSRS Baseline/Screening Version - Most Recent Suicide Attempt Date (Intellectual Product)\t(+)-secoisolariciresinol synthesis ((+)-secoisolariciresinol metabolic process)\tFIGO stage IIA carcinoma of the fallopian tube (Stage II Fallopian Tube Cancer)", + "output": "FIGO stage IIA carcinoma of the fallopian tube (Stage II Fallopian Tube Cancer)" + }, + { + "input": "Definition: Malignant Peripheral Nerve Sheath Tumor described as a malignant peripheral nerve sheath tumor that affects the esophageal wall.\nConcepts: Glomerular Sclerosis (Nephropathies and tubular disorders NEC)\tPPP1R60 (Gene or Genome)\tKaryotype 47,XXX (Other sex chromosome abnormalities, female phenotype, not elsewhere classified)\tEsophageal Malignant Peripheral Nerve Sheath Tumor (Neoplastic Process)\tMorbillivirus Infection (Morbillivirus Infections)", + "output": "Esophageal Malignant Peripheral Nerve Sheath Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Not-Done Reason described as the explanation given as to why pharmacokinetic parameter was not assessed.\nConcepts: Pharmacokinetic Parameter Reason Not Done (Idea or Concept)\tGDS01-Find Life Exciting (GDS Questionnaire Question)\tTransmembrane Protein 138 Gene (Genes, Regulator)\tPhotosensitive myoclonic-tonic-clonic seizure (Disease or Syndrome)\tHuelle cell development (developmental process involved in reproduction)", + "output": "Pharmacokinetic Parameter Reason Not Done (Idea or Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as a combination preparation containing the third-generation cephalosporin ceftazidime and the sodium salt form of avibactam, a non-beta-lactam beta-lactamase inhibitor, with antibiotic and beta-lactamase inhibiting activity, respectively. Upon administration, ceftazidime binds to essential penicillin-binding proteins (PBPs) and inhibits cell wall synthesis in certain bacteria. Avibactam binds to and inactivates beta-lactamases, thereby protecting ceftazidime from degradation and increasing ceftazidime's efficacy.\nConcepts: Design (Activity)\tCeftazidime/Avibactam Sodium (Cephalosporins)\tcadmium bromatum/cadmium bro (Inorganic Chemical)\tSpermatic (cell type)\tKrypton laser (Ion laser)", + "output": "Ceftazidime/Avibactam Sodium (Cephalosporins)" + }, + { + "input": "Definition: something described as a non-taxonomic grouping of bacterial species that are phenotypically or genetically similar to the Mycobacterium tuberculosis species.\nConcepts: Hemodynamic instability (Disease or Syndrome)\tGrade 1 Pleural hemorrhage (Finding)\tMycobacterium tuberculosis complex (Non-photochromogenic mycobacteria)\tMAP3K14 gene (Gene or Genome)\tHLA DQ beta Chains (Immunologic Factor)", + "output": "Mycobacterium tuberculosis complex (Non-photochromogenic mycobacteria)" + }, + { + "input": "Definition: Laboratory or Test Result described as an immunohistochemical staining finding indicating that 31-40 percent of the cells in a tissue sample are expressing estrogen receptor.\nConcepts: Hematohistioblast (Cell Fraction)\tInteractions (physical chemical interaction)\tEstrogen Receptor Positive by Immunohistochemistry 31-40 Percent (Estrogen Receptor Positive by Immunohistochemistry)\tbeta-endorphin receptor activity (neuropeptide receptor activity)\tpositive regulation of postsynaptic cytosolic calcium concentration (regulation of postsynaptic cytosolic calcium ion concentration)", + "output": "Estrogen Receptor Positive by Immunohistochemistry 31-40 Percent (Estrogen Receptor Positive by Immunohistochemistry)" + }, + { + "input": "Definition: Pharmacologic Substance described as an autologous dendritic cell (DCs) vaccine targeting prostate cancer with immunostimulating activity. The autologous DC vaccine is prepared via transfecting DCs with mRNAs extracted from primary prostate cancer tissue, and mRNAs of human telomerase reverse transcriptase (hTERT) and survivin. Upon administration, this DC vaccine may elicit a potent cytotoxic T-cell (CTL) response against prostate cancer cells, resulting in tumor cell death. Both hTERT and survivin are essential in neoplastic growth, and are considered to be universal tumor antigens. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95771\" active clinical trials using this agent.\nConcepts: response to glucocorticoid (Cell Function)\tcompression of spinal cord (Disease or Syndrome)\tPlatelet-Derived Growth Factor Receptor, Beta Polypeptide wt Allele (PDGFRB gene)\tPrimary Prostate Cancer Tissue/hTERT/Survivin mRNA-loaded Autologous Dendritic Cell Vaccine (Immunologic Factor)\tDiseases, Coronary (Myocardial Ischemia)", + "output": "Primary Prostate Cancer Tissue/hTERT/Survivin mRNA-loaded Autologous Dendritic Cell Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: something described as equipment designed for automated or semiautomated aspiration (i.e., suction) and irrigation of body cavities and/or other body areas. These devices typically include pumps that deliver the liquid and/or suction the debris, an easy-to-handle (e.g., pistol-like) handpiece that usually has a clamp to control the power of the irrigation/suctioning flush, and appropriate tubing to connect the handpiece to the main suction and irrigation unit. The equipment is frequently supplied with dedicated auxiliary irrigation kits that may include connectors, splash shields, and adapters; some devices use the hospital vacuum system. Aspirator/irrigators are intended to clean and improve visualization of clinical or surgical procedure sites (e.g., body cavities) by irrigating and removing fluids, necrotic tissues, and debris. Dedicated aspirator/irrigators are available for surgical, ophthalmic, dental, wound care, and uterine procedures; devices intended for endoscopic and laparoscopic procedures are also available.\nConcepts: Absence deformity of leg and congenital cataract syndrome (Absence of lower limb)\tdownregulation of pteridine metabolic process (negative regulation of nitrogen compound metabolic process)\tTumour lysis syndrome (Other specified metabolic disorders)\tExcessive chromium intake (Finding)\tAspirator/Irrigators (Electromechanical Devices)", + "output": "Aspirator/Irrigators (Electromechanical Devices)" + }, + { + "input": "Definition: something described as a lyophilized formulation containing cultures of a low-virulent strain of Streptococcus pyogenes, treated and killed with penicillin G, with potential sclerosing, immunostimulating and antineoplastic activity. Besides from picibanil's direct damaging effect as a sclerosing agent, it seems to have multiple effects on the immune system as a non-specific immunostimulant. Picibanil activates the host immune system by stimulating the activity of natural killer cells, macrophages and lymphocytes, and by enhancing the production of several key immune mediators, including interleukins and tumor necrosis factor.\nConcepts: autologous cultured acute myeloid leukemia-specific cytotoxic T lymphocytes (therapeutic autologous lymphocytes)\tPicibanyl (Biological Factors)\tArgon Plasma Coagulation (Ablation)\tGrade 1 Hyperkeratosis, CTCAE (Hyperkeratosis, CTCAE)\tcarcinoma mucin secreting (Neoplasms, Cystic, Mucinous, and Serous)", + "output": "Picibanyl (Biological Factors)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate.\nConcepts: Abnormal proportion of marginal zone B cells (Abnormal proportion of memory B cells)\tC.L.F.pancreas suprt mult-or (Nutraceuticals)\t3,5-dichlorocatechol 1,2-dioxygenase activity (Molecular Function)\tSRY-RELATED HMG-BOX GENE 2 (Gene or Genome)\tMicroscopic Findings Test (Test Name)", + "output": "3,5-dichlorocatechol 1,2-dioxygenase activity (Molecular Function)" + }, + { + "input": "Definition: carboxy-lyase activity described as catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products.\nConcepts: CDISC SDTM Cardiovascular Test Name Terminology (Intellectual Product)\tLaceration(s), Peritoneal (Laceration)\tImmunospot Assays, Enzyme-Linked (Immunoassay method)\tphosphopyruvate carboxylase activity (Molecular Function)\tendothelial cell fate determination (cell fate determination)", + "output": "phosphopyruvate carboxylase activity (Molecular Function)" + }, + { + "input": "Definition: Nicotine Replacement Agent described as a device used to inhale (breathe in) small doses of nicotine through the mouth. The nicotine is absorbed through the lining of the mouth and goes into the blood. This helps stop nicotine cravings, and relieves symptoms that occur when a person is trying to quit smoking. A prescription is needed for nicotine inhalers.\nConcepts: Groups, Control (Research Design)\tNicotine inhaler (Medical Device)\th.umol/l/(kg/m2) (Quantitative Concept)\tFAC100-Limit: Lifting Less Than 5 Lbs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tthiosulfate binding (anion binding)", + "output": "Nicotine inhaler (Medical Device)" + }, + { + "input": "Definition: protein-containing complex binding described as interacting selectively and non-covalently with the P-TEFb complex.\nConcepts: MONOLE (Blood Cell Count Ratio Measurement)\tLaboratory tubing clamp (Laboratory instruments and equipment)\tdna fragmentation (Molecular Function)\tMale-to-Female Transsexual Animal (Animal)\tP-TEFb complex binding (Molecular Function)", + "output": "P-TEFb complex binding (Molecular Function)" + }, + { + "input": "Definition: something described as the non-circulating form of serum amyloid A protein. It is found deposited in a variety of tissues during AMYLOIDOSIS.\nConcepts: peer reviews (Health Care Activity)\tTreatment Response Determinations (Therapeutic evaluation)\tAmyloid Fibril Protein AA (Biologically Active Substance)\tEstrogen-responsive protein Efp controls cell cycle and breast tumors growth (Cell Function)\tEPIC-26 - Overall Problem Urinary Function (EPIC-26 Questionnaire Question)", + "output": "Amyloid Fibril Protein AA (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a molecular genetic abnormality indicating the presence of a mutation in exon 20 of the ERBB2 gene.\nConcepts: PSA Level Less than One Hundred (Laboratory or Test Result)\tIntermittent Energy Output (Finding)\tErb-B2 Receptor Tyrosine Kinase Exon 20 Mutation (ERBB2 Gene Mutation)\tintramolecular transferase activity, transferring hydroxy groups (Molecular Function)\tCCND1 Positive (Positive Laboratory Test Result)", + "output": "Erb-B2 Receptor Tyrosine Kinase Exon 20 Mutation (ERBB2 Gene Mutation)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had trouble shifting back and forth between different activities that require thinking.\nConcepts: I have trouble shifting back and forth between different activities that require thinking (Clinical or Research Assessment Question)\tPen Gram Protein (Quantitative Concept)\tCommiphora myrrha Oil (M [Preparations])\tCardiac standstill (Ventricular arrhythmias and cardiac arrest)\tExostosis, anetoderma, brachydactyly type E syndrome (Osteochondropathy)", + "output": "I have trouble shifting back and forth between different activities that require thinking (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Bacterium described as a genus of aerobic, Gram positive, cocci shaped bacterium assigned to the phylum Firmicutes and the family Planococcaceae.\nConcepts: mntl/bhvl hlth ndvdl 8 (mental health counseling)\tPlanococcus Bacteria (Planococcaceae)\tPHQ-15 - Trouble Sleeping (Intellectual Product)\tJeune thoracic dysplasia (Osteochondrodysplasias)\tClubmosses (Plant)", + "output": "Planococcus Bacteria (Planococcaceae)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of eyelid carcinoma, following the rules of the TNM AJCC v8 classification system.\nConcepts: Eyelid Carcinoma Clinical TNM Finding v8 (Eyelid Carcinoma TNM Finding v8)\tperiostin protein, human (Amino Acid, Peptide, or Protein)\tBack injury NOS (Injury or Poisoning)\tmetacyclogenesis (development of symbiont in host cell)\tTSCYC1-Acting as If Didn't Have Feelings (TSCYC Questionnaire Question)", + "output": "Eyelid Carcinoma Clinical TNM Finding v8 (Eyelid Carcinoma TNM Finding v8)" + }, + { + "input": "Definition: Victim status described as removal of a dead body from the earth after burial.\nConcepts: Ubiquitination Activating Enzyme E1 (Enzyme)\tExhumations (Human remains finding)\tSponge Counters, Surgical, Holding Rack (Sponge Counters, Surgical)\tType IV hypersensitivity reaction (Collagen Diseases)\tHAEMOPHILUS HAEMOLYTICUS, PENICILLINASE NEGATIVE (Haemophilus haemolyticus)", + "output": "Exhumations (Human remains finding)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate, or extent of peripheral tolerance induction.\nConcepts: positive regulation of interleukin-10 anabolism (positive regulation of interleukin-10 production)\tSSH3BP1 protein, human (Adaptor Proteins, Signal Transducing)\tNucleoporin 358 (Ligase)\tregulation of peripheral tolerance induction (Biologic Function)\tVirulence (Biologic Function)", + "output": "regulation of peripheral tolerance induction (Biologic Function)" + }, + { + "input": "Definition: negative regulation of cellular amino acid biosynthetic process described as any process that stops, prevents or reduces the frequency, rate or extent of leucine biosynthetic process.\nConcepts: Vocabulary Words (Languages)\tPlexus lienalis (Abdominal plexus)\tnegative regulation of leucine anabolism (regulation of leucine biosynthetic process)\tdown regulation of aspartate secretion (Molecular Function)\tQuinolizidines (Organic Chemical)", + "output": "negative regulation of leucine anabolism (regulation of leucine biosynthetic process)" + }, + { + "input": "Definition: Serum Proteins described as proteins found in blood, milk, etc.\nConcepts: Serum Globulin (Amino Acid, Peptide, or Protein)\tSlow-growing nails (Abnormal nail growth)\tOxazepam measurement (SPECIFIC DRUG AND TOXICOLOGY TESTS)\tG protein-coupled neurotensin receptor activity (Molecular Function)\tvinyl chloride (Special Chemical Categories)", + "output": "Serum Globulin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Carbon Monoxide Diffusing Capacity Decreased, CTCAE described as 6-8 units below LLN; for follow-up, an asymptomatic decrease of >5-8 units (ml/min/mm Hg) below the baseline value; symptomatic and intervention not indicated\nConcepts: Cardiolipin IgM Antibody Measurement (Laboratory Procedure)\tRho GTPase-Activating Protein 22 (Biologically Active Substance)\tCellular Tumor Antigen p53 G302fs (TP53 Protein Variant)\tinduction by symbiont of host ethylene-mediated defense response (Organism Function)\tGrade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE (Finding)", + "output": "Grade 2 Carbon Monoxide Diffusing Capacity Decreased, CTCAE (Finding)" + }, + { + "input": "Definition: Europe described as a peninsula in Southeast EUROPE between the Adriatic and Ionian seas on the West and Aegean and Black Seas on the East.\nConcepts: CDC group EF22 (Bacterium)\turethr(o)- (Pelvis)\tEmotional seizure (Disease or Syndrome)\tFOWLVAC (Immunologic Factor)\tBalkan Peninsula (Europe)", + "output": "Balkan Peninsula (Europe)" + }, + { + "input": "Definition: something described as histone deacetylase 3 (428 aa, ~49 kDa) is encoded by the human HDAC3 gene. This protein is involved in the negative regulation of apoptosis, histone deacetylation and signal regulation.\nConcepts: spindle midzone (cellular anatomical entity)\tEruption of tooth (Organ or Tissue Function)\tRPD3-2 (Histone Deacetylase)\tCYP3A4*18 Allele (CYP3A4 gene)\tHelianthemum Mill., 1754 (Cistaceae)", + "output": "RPD3-2 (Histone Deacetylase)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a method of birth coaching in assisting the mother by her partner, to relieve her distress during labor and delivery by applying relaxation techniques and encouraging abdominal breathing.\nConcepts: Cafe\u00edna (Drug allergens)\tPODCI1-Button Buttons (Intellectual Product)\tDextropropoxyphene hydrochlor. (Methadone analog-containing product)\tBirth Partner Coached Method of Delivery (Therapeutic or Preventive Procedure)\tBacillus medusa (Bacillus species)", + "output": "Birth Partner Coached Method of Delivery (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a group of neurons embedded in the pontine central gray of the pontine tegmentum. Located dorsal to the internal genu of the facial nerve, it is found in the human ( Paxinos-2012 ), the macaque ( Paxinos-2009a ), the rat ( Swanson-2004 ), and the mouse ( Franklin-2008 ). Functionally it is part of the dorsal pontine gray of the subcortical motor system ( Swanson-2004 ).\nConcepts: Contracture of the proximal interphalangeal joint of the 2nd finger (Flexion contracture of the 2nd finger)\tsupragenual nucleus (Body Part, Organ, or Organ Component)\tPotentilla tormentilla / bloodroot (Plant)\tKidney Infection (Renal tract inflammation)\tanti-LAG-3/PD-L1 bispecific antibody FS118 (Pharmacologic Substance)", + "output": "supragenual nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.\nConcepts: lymph nodes (Pathology procedure)\tCoronavirus group 1 (Orthocoronavirinae)\tMeiotic Spindle Apparatus (Spindle)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level of Diagnostic Certainty (Classification)\tPartially duplicated kidney (Accessory kidney)", + "output": "Meiotic Spindle Apparatus (Spindle)" + }, + { + "input": "Definition: Differentiation Inducer described as the dihydrochloride salt of efatutazone, an orally bioavailable agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma) with potential antineoplastic activity. Efatutazone binds to and activates PPAR-gamma, a nuclear hormone receptor and a ligand-activated transcription factor controling gene expression involved in macromolecule metabolism and cell differentiation, specifically adipocyte differentiation. Mediated through activation of PPAR-gamma, this agent is capable of inducing cell differentiation and apoptosis, thereby leading to a reduction in cellular proliferation.\nConcepts: bunolol (Organic Chemical)\tBACOAIND (Indicator)\tcalcineurin-NFAT signaling cascade (Cell Function)\tinolitazone dihydrochloride (Pharmacologic Substance)\tEpicardium proper (Body Part, Organ, or Organ Component)", + "output": "inolitazone dihydrochloride (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as diagnosis, consultation, and procedures intended to prevent, identify, or treat birth defects, congenital anomalies, or conditions.\nConcepts: ACTIVATOR, ULTRAVIOLET, FOR POLYMERIZATION (Medical Device)\tsucrose mediated signaling (Molecular Function)\tX-linked mental retardation 39 (Disease or Syndrome)\tgenetics (Health Care Activity)\tImidazoline Receptor Antisera-Selected Protein (Amino Acid, Peptide, or Protein)", + "output": "genetics (Health Care Activity)" + }, + { + "input": "Definition: abnormal frequency of menses described as abnormally high variation in the amount of time between periods.\nConcepts: WHODAS 2.0 36-item Version Proxy-administered - I Am (Fill in the Blank) of this Person (Intellectual Product)\tRepair of hernia (Therapeutic Surgical Procedure)\tPigments (Thesaurus of Psychological Index Terms)\tThymosin Beta-4, Y-Chromosomal (Cytoskeletal Proteins)\tIrregular menses (menstruation and menopause)", + "output": "Irregular menses (menstruation and menopause)" + }, + { + "input": "Definition: something described as any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).\nConcepts: aerobic respiration, using carbon monoxide as electron donor (Molecular Function)\tMilliliter/hour (Quantitative Concept)\tdown-regulation of antibacterial peptide secretion (negative regulation of antibacterial peptide production)\tMale (Organism Attribute)\tDrug Sensitivity Assay, Microbial (Microbiology procedure)", + "output": "Drug Sensitivity Assay, Microbial (Microbiology procedure)" + }, + { + "input": "Definition: Arbitrary Unit of Substance Content described as a quantity equivalent to one thousand units (10E3 units).\nConcepts: Does the patient have depression (Intellectual Product)\t10^3 U (Quantitative Concept)\tCurved phalanges of the toes (Anatomical Abnormality)\tUnexpected/Unintended Radiation Output (Radiation Output Problem)\tregulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway (regulation of G protein-coupled receptor signaling pathway)", + "output": "10^3 U (Quantitative Concept)" + }, + { + "input": "Definition: something described as RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. Transcription Corepressor Genes encode a group of transcriptional repressor/co-repressor factors that suppress transcription by binding to the operator.\nConcepts: IVD Test Reagent/Kits, Microbiology, Standard, Blood Culture Media (Medical Device)\tspindle breakdown (spindle organization)\tcaste determination, influence by environmental factors (caste determination)\tTranscription Repressor/Corepressor Gene (Gene or Genome)\tCordycepin Triphosphate (Antibiotic)", + "output": "Transcription Repressor/Corepressor Gene (Gene or Genome)" + }, + { + "input": "Definition: Contraceptive methods female described as contraceptive methods that utilize HORMONAL CONTRACEPTIVE AGENTS.\nConcepts: Hormonal Birth Control (Contraceptive methods female)\tGrade 2 Movements involuntary (Movements Involuntary, CTCAE)\tCDC Enteric group 10 (Bacterium)\tAngola (Geographic Area)\tCongenital growth hormone deficiency (Isolated somatotropin deficiency)", + "output": "Hormonal Birth Control (Contraceptive methods female)" + }, + { + "input": "Definition: something described as an interferon regulatory factor that recruits STAT1 PROTEIN and STAT2 PROTEIN heterodimers to interferon-stimulated response elements and functions as an immediate-early protein.\nConcepts: high affinity oligopeptide transporter activity (oligopeptide transmembrane transporter activity)\tRegulatory Factor-9, Interferon (Amino Acid, Peptide, or Protein)\tThermoregulation intervention (Therapeutic or Preventive Procedure)\tEC 3.4.19.12 (Amino Acid, Peptide, or Protein)\tTobacco Use and Related Risk Factors, Surveillance (Cancer Surveillance Project)", + "output": "Regulatory Factor-9, Interferon (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Agenesis of molar described as agenesis of secondary molar tooth.\nConcepts: Auricular malformation (Abnormality of the outer ear)\tproteolysis within ER associated with antigen processing and presentation (Molecular Function)\tAgenesis of permanent molar (Finding)\tOvarian Dermoid Cyst with Angiosarcoma (Neoplastic Process)\tZUCLOMIPHENE CITRATE (Organic Chemical)", + "output": "Agenesis of permanent molar (Finding)" + }, + { + "input": "Definition: Electromechanical Devices described as enclosures designed to provide a confined environment for the delivery and/or exhaustion of gases, vapors, and/or particles. Hoods are typically made of rigid plastics or metal (e.g., stainless steel); they are frequently connected by hoses or ducts to gas sources to provide a controlled atmosphere inside the hood and/or to exhaust gases and vapors to the outside. Some hoods include blowers, filters, and other devices according to the procedure to be performed or the protection needed for a particular application; ductless hoods recirculate the air inside the hood to the room environment after appropriate filtration. Hoods are used in the performance of procedures such as distillation and chemical reactions isolated from the general room environment and/or to exhaust toxic fumes from areas where hazardous or potentially hazardous materials are manipulated (e.g., clinical laboratories). Laboratory hoods are not biological safety enclosures; they should not be used when infectious or potentially infectious materials are handled.\nConcepts: Glucose Transport Inhibition (Molecular Transport)\tLaboratory Hoods (Electromechanical Devices)\tdateRange (Temporal Concept)\tMosaic Viruses, Tobacco (Plant Viruses)\tAttributes, Disease (Pathologic Processes)", + "output": "Laboratory Hoods (Electromechanical Devices)" + }, + { + "input": "Definition: Intellectual Product described as screener and Opioid Assessment for Patients with Pain - Revised - How often have you felt a need for higher doses of medication to treat your pain?\nConcepts: SOAPP-R - Need Higher Doses of Medication (Intellectual Product)\tTherapeutic Plasmapheresis (Operative procedure on vein)\tSCAPHOID-TRAPEZOID JOINT (Wrist joint)\tAbnormality of the anterior segment of the eye (Anatomical Abnormality)\tDNA hypermethylation (DNA Methylation Regulation)", + "output": "SOAPP-R - Need Higher Doses of Medication (Intellectual Product)" + }, + { + "input": "Definition: something described as the approximate intake in one day of folate and folate derivative.\nConcepts: AEROMONAS VERONII (Aeromonas)\tsouthern black widow (Family Theridiidae)\tHuman immunodeficiency virus negative (Human immunodeficiency virus (HIV) status)\tThalami, Pulvinar (Lateral Nuclear Group)\tEstimated intake of folate and folate derivative in 24 hours (Quantitative Concept)", + "output": "Estimated intake of folate and folate derivative in 24 hours (Quantitative Concept)" + }, + { + "input": "Definition: Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated - Parkinsonism-Rigidity: Neck.\nConcepts: Thebesian valve (Heart)\tGeminin (Amino Acid, Peptide, or Protein)\tAerosol tent, pediatric (Respiratory tent)\tMorphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, (5alpha)- (Drug allergens)\tESRSA1-Rigidity: Neck (ESRS-A Clinical Classification Question)", + "output": "ESRSA1-Rigidity: Neck (ESRS-A Clinical Classification Question)" + }, + { + "input": "Definition: Cell Function described as any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.\nConcepts: Nurses' Health Study II Activity and Inactivity Questionnaire (Clinical or Research Assessment Questionnaire)\tMinute Times Picomole per Milliliter (Quantitative Concept)\tesophageal cancer stage IIB (Stage II Esophageal Cancer)\tcellular detoxification (Metabolic Detoxication, Drug)\tCetrelimab (Amino Acid, Peptide, or Protein)", + "output": "cellular detoxification (Metabolic Detoxication, Drug)" + }, + { + "input": "Definition: N-acetyltransferase activity described as catalysis of the reaction: D-tryptophan + acetyl-CoA = N-acetyl-D-tryptophan + CoA + H(+).\nConcepts: Inverse Role Entity (Terminology Entity)\tProcessus condylaris (Bone structure of cranium)\tProcessing, Word (Occupational Activity)\tIVD Test Reagent/Kits, Immunoassay, Fertility Hormone, Dehydroepiandrosterone/Dehydroepiandrosterone-Sulfate (IVD Test Reagent/Kits, Immunoassay, Fertility Hormone)\tacetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity (N-acetyltransferase activity)", + "output": "acetyl-CoA-D-tryptophan-alpha-N-acetyltransferase activity (N-acetyltransferase activity)" + }, + { + "input": "Definition: Virus described as a species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.\nConcepts: E Isomer (Conceptual Entity)\tvirus lassa (Arenaviruses, Old World)\tAPOC2 (Laboratory Procedure)\tFungus-based Natural Product (Natural Products)\tOvarian Lymphoma (Lymphoma by Site)", + "output": "virus lassa (Arenaviruses, Old World)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as ovarian dysgenesis in female homozygotes and facultative deafness in male and female homozygotes associated with delayed mental and physical development and other defects.\nConcepts: Urine Pellet (Body Substance)\tCAIX Inhibitor DTP348 (Carbonic Anhydrase Inhibitors)\tion channel complex (transmembrane transporter complex)\tGonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance (Auditory system hereditary disorder)\tPQL0810 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)", + "output": "Gonadal dysgenesis with auditory dysfunction, autosomal recessive inheritance (Auditory system hereditary disorder)" + }, + { + "input": "Definition: Disease or Syndrome described as exotropia in an individual who has previously had esotropia or esophoria.\nConcepts: Upper GI Complete Response (Finding)\tOX40 Ligand (Amino Acid, Peptide, or Protein)\tConsecutive exotropia (Disease or Syndrome)\tglucosamine sulfate/chondroitin sulfate tablet (Clinical Drug)\tanti-CD22 monoclonal antibody-MMAE conjugate DCDT2980S (Amino Acid, Peptide, or Protein)", + "output": "Consecutive exotropia (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the tumor shows invasion into the capsule.\nConcepts: B7-1, intercellular adhesion molecule-1, and leukocyte function-associated antigen-3 (Immunologic Adjuvants)\tchemical peels skin (Procedure on skin)\tNEWLPROG (Finding)\tbcr-abl vaccine (Cancer Vaccines)\tMasaoka-Koga Stage II (Thymoma by Masaoka-Koga Stage)", + "output": "Masaoka-Koga Stage II (Thymoma by Masaoka-Koga Stage)" + }, + { + "input": "Definition: Congenital Abnormality described as a congenital abnormality characterized by the presence of a duplicated segment of the esophagus. The duplicated segment may by tubular or cystic.\nConcepts: Esophageal duplication (Congenital Abnormality)\tABOMASUM (Stomach)\tGrade 4 Laryngospasm (Laryngospasm, CTCAE)\tcoronary; cataract (CATARACT, MARNER TYPE)\tT-Cell Replacing Factor (Immunologic Factor)", + "output": "Esophageal duplication (Congenital Abnormality)" + }, + { + "input": "Definition: something described as >30% BSA; systemic intervention indicated\nConcepts: Rossiter System(TM) individual each 15 minutes (Health Care Activity)\tNA17 Peptide (Amino Acid, Peptide, or Protein)\tSystolic anterior motion of the mitral valve (Echocardiogram abnormal)\tHigh Risk Plasma Cell Myeloma (Neoplastic Process)\tGrade 3 Folliculitis (Folliculitis, CTCAE)", + "output": "Grade 3 Folliculitis (Folliculitis, CTCAE)" + }, + { + "input": "Definition: something described as an increased concentration of cystine within cells. This finding can be demonstrated on leukocytes, but is not specific to blood cells.\nConcepts: Timers, Radiotherapy (Timer, device)\tgas transport (Biological Transport)\tMIR204 Gene (Gene or Genome)\tElevated intracellular cystine (Abnormal cellular physiology)\talpha cell; tumor, unspecified site (Islet cell neoplasms and APUDoma NEC)", + "output": "Elevated intracellular cystine (Abnormal cellular physiology)" + }, + { + "input": "Definition: something described as a person worthy of responsibility or trust or one held accountable.\nConcepts: Hyperhomocystinemia (LABORATORY ABNORMALITIES)\tBermuda Grass Pollen IgA Measurement (Laboratory Procedure)\tResponsible to (Persons)\torientals (Asian or Pacific islander)\tnegative regulation of somatostatin secretion (Cell Function)", + "output": "Responsible to (Persons)" + }, + { + "input": "Definition: Finding described as symptomatic; medical intervention indicated; limiting instrumental ADL\nConcepts: Position Effect Trial (Research Activity)\tGrade 2 Duodenal Ulcer, CTCAE (Duodenal Ulcer, CTCAE 5)\t25-hydroxycholecalciferol-23-hydroxylase activity (vitamin D 23-hydroxylase activity)\tProchlorperazine maleate (Propylpiperazine derivative of phenothiazine)\tS,S-dimethyl-beta-propiothetin dimethyl-sulfide-lyase (carbon-sulfur lyase activity)", + "output": "Grade 2 Duodenal Ulcer, CTCAE (Duodenal Ulcer, CTCAE 5)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor.\nConcepts: alpha>2< HS glycoprotein (Fetuins)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, F13B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tMicroascus brevicaulis S.P.Abbott, 1998 (Mitosporic Fungi)\tEdg-5 sphingosine 1-phosphate receptor binding (endothelial differentiation G protein-coupled receptor binding)\tSPMA (Amino acid derivative)", + "output": "Edg-5 sphingosine 1-phosphate receptor binding (endothelial differentiation G protein-coupled receptor binding)" + }, + { + "input": "Definition: something described as a method of detecting sequence differences between normal DNA and the DNA to be tested. It is commonly used as a screening method to detect potential mutations in a gene.\nConcepts: Papillon-Lef\u00e8vre syndrome (Keratoderma, Palmoplantar, Diffuse)\theteroduplex analysis (Molecular Biology Research Technique)\tthorium (Element, Ion, or Isotope)\tConceptual (Conceptual Entity)\tProduct containing midodrine (Organic Chemical)", + "output": "heteroduplex analysis (Molecular Biology Research Technique)" + }, + { + "input": "Definition: Supplemental Qualifiers Tabulation Dataset described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the pharmacogenomics/genetics methods and supporting information domain.\nConcepts: urban area (Social Environment)\tVery severe peripheral visual field loss (Finding)\tHippocampus (Gyrus of limbic lobe)\tBlepharophimosis (Eye)\tPharmacogenomics/Genetics Methods and Supporting Information Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)", + "output": "Pharmacogenomics/Genetics Methods and Supporting Information Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: Cyclic AMP-Responsive DNA-Binding Protein described as cyclic AMP-responsive element-binding protein 1 (341 aa, ~37 kDa) is encoded by the human CREB1 gene. This protein plays a role in transcriptional regulation.\nConcepts: Reduced circulating fibronectin level (Finding)\tCREB-1 (Amino Acid, Peptide, or Protein)\t1-Methylhistidinuria (Finding)\tauditory discrimination (Speech)\tATLAS - Treatment With Antibiotics (ATLAS Clinical Classification Question)", + "output": "CREB-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Carcinoma, Lobular described as a breast carcinoma characterized by the presence of a predominant lobular carcinoma in situ component and a minor component of invasive carcinoma. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9136\" active clinical trials using this agent.\nConcepts: diadenosine tetraphosphate metabolic process (Molecular Function)\tInfiltrating Lobular Breast Carcinoma with Predominant In Situ Component (Carcinoma, Lobular)\tStructure of companion artery to median nerve (Body Part, Organ, or Organ Component)\tTremolite Asbestos (Asbestos)\tMyeloblasts Under 5 Percent of Peripheral Blood White Cells (Myeloblasts Under 10 Percent of Peripheral Blood White Cells)", + "output": "Infiltrating Lobular Breast Carcinoma with Predominant In Situ Component (Carcinoma, Lobular)" + }, + { + "input": "Definition: something described as a pathologic primary tumor TNM stage finding. The definition of pT3c stage finding depends on the particular type of cancer that it refers to; for example, for kidney cancer, pT3c stage finding is defined as follows: cancer with tumor grossly extending into the vena cava above the diaphragm, or invading the wall of the vena cava; for fallopian tube cancer, pT3c stage finding is defined as follows: cancer with peritoneal metastasis outside the pelvis and more than 2 cm in diameter.\nConcepts: male meiosis cytokinesis (Cell Function)\trndx community coping impairment (Coping responses)\tglyoxylic transacetase activity (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)\tpT3c Cancer Stage Finding (Finding)\tFAQ0207 (Intellectual Product)", + "output": "pT3c Cancer Stage Finding (Finding)" + }, + { + "input": "Definition: something described as familial embryonal neoplasm derived from nephrogenic blastemal cells. Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed. Comprises approximately 1% of Wilms tumors. (AFIP fascicle version 2.0 mo011000) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8496\" active clinical trials using this agent.\nConcepts: Aspirin [musculoskeletal use] (Platelet Aggregation Inhibitors)\tHereditary Renal Adenosarcoma (Neoplastic Process)\tCephalosporium, NOS (Plectosphaerellaceae)\tanterograde dendritic transport of messenger ribonucleoprotein complex (protein localization to postsynapse)\tGUCY1B2 protein, human (Amino Acid, Peptide, or Protein)", + "output": "Hereditary Renal Adenosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Antibiotic described as the sulfate salt form of polymyxin B1, a polypeptide obtained from Bacillus polymyxa strains with antimicrobial activity. Polymyxin B1 exerts its antimicrobial effect through its cationic detergent action on cell membranes. Specifically, this antibiotic binds to the negatively charged site in the lipopolysaccharide layer of the bacterial cell membrane via electrostatic affinity with the positively charged amino groups in the cyclic peptide portion. Subsequently, the fatty acid portion of polymyxin B1 dissolves in the hydrophobic region of the bacterial cell membrane. This results in an alteration in cell membrane structure, disruption of cell wall integrity and an increase in permeability for water and molecules. This will eventually lead to bacterial cell death.\nConcepts: Aberrant Crypt Focus (Precancerous Conditions)\tQ-LES-Q - Taken Courses or Going to Class (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, WT1 (Medical Device)\tPolymyxin B1 Sulfate (Polymyxin Antibiotic)\tENCEPHALOPATHY, CALLOSAL DEMYELINATING (Leukoencephalopathy)", + "output": "Polymyxin B1 Sulfate (Polymyxin Antibiotic)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Lung Version 4 (FACT-L Version 4) Additional Concerns: I feel tightness in my chest.\nConcepts: preferences (Thesaurus of Psychological Index Terms)\tnegative regulation of fibronectin-dependent thymocyte migration (Cell Function)\tFACT-L Version 4 - I Feel Tightness in My Chest (FACT-L Version 4 Questionnaire Question)\tMediastinal Germ Cell Tumor T0 TNM Finding (Mediastinal Germ Cell Tumor Primary Tumor TNM Finding)\tdendrite development (anatomical structure development)", + "output": "FACT-L Version 4 - I Feel Tightness in My Chest (FACT-L Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as the directed movement of arginine across a membrane.\nConcepts: Ureteroscopes, Rigid (Medical Device)\tpositive regulation of cGMP-mediated signaling (Molecular Function)\tPelvis Cancer pT3a TNM Finding v8 (Finding)\targinine transmembrane transport (cation transmembrane transport)\tPosterior pubic shear (Pubic Shear)", + "output": "arginine transmembrane transport (cation transmembrane transport)" + }, + { + "input": "Definition: positive regulation by symbiont of host programmed cell death described as a symbiont process in which a molecule secreted by the symbiont activates a resistance gene-dependent defense response signaling pathway in the plant host, in order to activate a hypersensitive response to induce necrosis. In the plant, this process involves the direct or indirect recognition of the symbiont effector protein for example through plant resistance receptor or R proteins (or R genes).\nConcepts: Tuber, Plant (Plant Roots)\tinduction by symbiont of host resistance gene-dependent defense response (modulation by symbiont of host resistance gene-dependent defense response)\tESRSA1TC (Intellectual Product)\tmV/sec (Quantitative Concept)\tChilopoda (Subphylum Myriapoda)", + "output": "induction by symbiont of host resistance gene-dependent defense response (modulation by symbiont of host resistance gene-dependent defense response)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).\nConcepts: Community or Hospital Associated Blood Products Testing Facility (Health Care Related Organization)\tA-esterase (Phosphoric Triester Hydrolases)\tCoordinator (Persons)\tentry into reproductive diapause (entry into diapause)\temetine hcl (Protein Synthesis Inhibitors)", + "output": "A-esterase (Phosphoric Triester Hydrolases)" + }, + { + "input": "Definition: Medical Device described as baths used for the cooling of a patient in order to lower the body temperature rapidly.\nConcepts: Information Storage (Storage)\tBaths, Freezing (Medical Device)\tRO7082859 (Immunologic Factor)\tAbnormal shape of limb bone (Abnormality of limb bone)\tGenus Flexibacter (Bacterium)", + "output": "Baths, Freezing (Medical Device)" + }, + { + "input": "Definition: Neurotransmitters & Neuroregulators described as non-essential amino acid; found primarily in gelatin and silk fibroin and used therapeutically as a nutrient; it is also a fast inhibitory neurotransmitter.\nConcepts: Metastatic Head and Neck Carcinoma (Metastatic Carcinoma)\tTCF1ALPHA (Transcription factor genes)\tGlykokoll (AMINO ACIDS PORPHYRINS)\tCd element (Metals, Heavy)\tGiant cell & spindle cell ca (Neoplastic Process)", + "output": "Glykokoll (AMINO ACIDS PORPHYRINS)" + }, + { + "input": "Definition: Remote location existing client without ICD diagnosis described as using personal training assessment methods in a comprehensive, subsequent, 60-minute, out-of-office meeting to assess the health status of an existing personal training client to reevaluate and/or develop a personal training plan.\nConcepts: Subfamily Alouattinae (Mammal)\tErythrocyte sedimentation rate (& level) (Red blood cell test)\tGrade 2 Recurrent Laryngeal Nerve Palsy, CTCAE (Finding)\tanatomical structure morphogenesis (Growth and Development function)\tsbsqnt 60min xofc ptrn ntak (Health Care Activity)", + "output": "sbsqnt 60min xofc ptrn ntak (Health Care Activity)" + }, + { + "input": "Definition: something described as the amount of time between one breath to the next breath calculated by inspiration time plus expiration time, per single respiratory cycle.\nConcepts: TI (Intellectual Product)\tcytosine synthesis (cytosine metabolic process)\tTracheal Obstruction, CTCAE (Finding)\tELTMBB (Elapsed Time)\tINO1001 (Poly(ADP-ribose) Polymerase Inhibitors)", + "output": "ELTMBB (Elapsed Time)" + }, + { + "input": "Definition: something described as a wheelchair component is a device intended for medical purposes that is generally sold as an integral part of a wheelchair, but may also be sold separately as a replacement part. Examples of wheelchair components are the following: Armrest, narrowing attachment, belt, extension brake, curb climber, cushion, antitip device, footrest, handrim, hill holder, leg rest, heel loops, and toe loops.\nConcepts: HANDRIM, WHEELCHAIR (Medical Device)\tRadiation (Electromagnetic Phenomena)\tcell morphogenesis involved in conjugation with cellular fusion (developmental process involved in reproduction)\tECG: left posterior fascicular block (Heart Block by ECG Finding)\tHis-Purkinje system cell development (cardiac cell development)", + "output": "HANDRIM, WHEELCHAIR (Medical Device)" + }, + { + "input": "Definition: Undifferentiated carcinoma described as a carcinoma without evidence of differentiation arising from the extrahepatic bile ducts.\nConcepts: Chloroquine-containing product (chloroquine)\tFAC10081 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tArachidonic Acid Lipoxygenase (Lipoxygenase)\tAnaplastic Carcinoma of Extrahepatic Bile Duct (Carcinoma of extrahepatic bile duct)\tregulation of calcium ion concentration in smooth ER (endoplasmic reticulum calcium ion homeostasis)", + "output": "Anaplastic Carcinoma of Extrahepatic Bile Duct (Carcinoma of extrahepatic bile duct)" + }, + { + "input": "Definition: ES ES Cell Line described as provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.\nConcepts: HES-5 (Cell)\tCUI (Unique Identifier)\tDFNB102 (EPS8 gene)\tFAC06127 (Intellectual Product)\tpositive regulation of violaceol II biosynthetic process (regulation of violaceol II biosynthetic process)", + "output": "HES-5 (Cell)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable allosteric inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor MK2206 binds to and inhibits the activity of Akt in a non-ATP competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.\nConcepts: SVN53-67/M57-KLH peptide vaccine (Pharmacologic Substance)\tAkt Inhibitor MK2206 (Pharmacologic Substance)\tMature T-Cell and NK-Cell Neoplasm (T-Cell and NK-Cell Neoplasm)\tGrade 2 Dyspepsia (Dyspepsia, CTCAE)\tGrade 1 Respiratory, Thoracic and Mediastinal Disorders - Other, Specify, CTCAE (Finding)", + "output": "Akt Inhibitor MK2206 (Pharmacologic Substance)" + }, + { + "input": "Definition: DNA ligase activity described as catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m).\nConcepts: Absent specific antibody response (Finding)\tgranulomatous lesions (Granuloma)\tpolynucleotide ligase (NAD+) activity (DNA ligase activity)\talpha-hydroxypropionate metabolism (Molecular Function)\tquercitrinase activity (Molecular Function)", + "output": "polynucleotide ligase (NAD+) activity (DNA ligase activity)" + }, + { + "input": "Definition: Bees, Wasps, Ants and Bugs described as insects of the family Formicidae, very common and widespread, probably the most successful of all the insect groups. All ants are social insects, and most colonies contain three castes, queens, males, and workers. Their habits are often very elaborate and a great many studies have been made of ant behavior. Ants produce a number of secretions that function in offense, defense, and communication.\nConcepts: Ant (living organism) (Formicoidea)\t3-BETA-HSD, ADRENAL AND GONADAL TYPE (Isomerase Gene)\tCDKN1B Gene (Gene Mutation)\tSulphoxone (Antitubercular Agents)\tEighty Nine (Natural Number)", + "output": "Ant (living organism) (Formicoidea)" + }, + { + "input": "Definition: something described as growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.\nConcepts: glial cell growth (Cell Function)\t89Zr-TAK-164 (Amino Acid, Peptide, or Protein)\tID-MS (Laboratory Procedure)\tWorkstations, Electrocardiography (Workstation)\tHOPS OIL (Natural Products)", + "output": "glial cell growth (Cell Function)" + }, + { + "input": "Definition: Neoplastic Process described as a squamous cell carcinoma that arises from the penis and is characterized by a mixture of morphologic patterns (e.g., high grade squamous cell carcinoma and verrucous carcinoma or warty-basaloid carcinoma).\nConcepts: Prostaglandin-Endoperoxide Synthase 2 wt Allele (Gene or Genome)\tcompetence (General clinical state finding)\tMixed Squamous Cell Carcinoma of the Penis (Non-Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis)\tIntervertebral foraminal space (BONES OF VERTEBRAL COLUMN)\talcohol dehydrogenase 1C (class I), gamma polypeptide (Gene or Genome)", + "output": "Mixed Squamous Cell Carcinoma of the Penis (Non-Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis)" + }, + { + "input": "Definition: something described as an Antiinflammatory Effect involves interference with, or restraint of, local events that constitute part of innate immunity, involve increased blood supply, and infiltration and activity of leukocytes at a site of injury or disease. Inflammation is induced by release of vasodilatory, opsonizing, and chemotactic mediators that attract phagocytizing macrophages and leukocytes; dilate local blood vessels, increasing local blood flow and capillary permeability; and induce pain.\nConcepts: Helpless (Emotional state observations)\tPyramidal layer of hippocampus (Neuronames Brain Hierarchy)\tAntiinflammatory Effect (Inflammatory Response)\tAortic valve prolapse (Aortic valve disorder)\tAletris farinosa / stargrass (Pharmacologic Substance)", + "output": "Antiinflammatory Effect (Inflammatory Response)" + }, + { + "input": "Definition: something described as terminology developed by a collaborative effort of the National Cancer Institute's Enterprise Vocabulary Services, the National Institute of Child Health and Human Development, and an international group of clinicians and informaticists to support the use of medical devices in the pediatric population.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Yersinia enterocolitica, IgG Antibody (IVD Test Reagent/Kits, Serology, Bacteria, Yersinia enterocolitica, Antibody)\tregulation of T-cell migration (Cell Function)\tspeaking (Communication)\tPediatric Medical Device Terminology (NICHD Terminology)\tSmoking Reduction (Individual Behavior)", + "output": "Pediatric Medical Device Terminology (NICHD Terminology)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus.\nConcepts: amnioserosa maintenance (Organism Function)\tLiving tissue equivalent (Biomedical or Dental Material)\tIMC-1C11 (Monoclonal Antibodies)\tClinical Investigator Network Contact (Human)\tresponse to ciliary neurotrophic factor (Cell Function)", + "output": "response to ciliary neurotrophic factor (Cell Function)" + }, + { + "input": "Definition: Argon and argon compound described as a noble gas with the atomic symbol Ar, atomic number 18, and atomic weight 39.948. It is used in fluorescent tubes and wherever an inert atmosphere is desired and nitrogen cannot be used.\nConcepts: new5min xofc NatAm ntak (Remote location new client without ICD diagnosis)\tPKP - Penetrating keratoplastly (Introduction procedure)\tHypotryptophanemia (Abnormal circulating tryptophan concentration)\tAr element (Element, Ion, or Isotope)\tPhaseolus vulgaris Lectins (Amino Acid, Peptide, or Protein)", + "output": "Ar element (Element, Ion, or Isotope)" + }, + { + "input": "Definition: something described as suicidal Ideation Questionnaire-JR - I thought about writing a will.\nConcepts: somatic diversification of immune receptors via gene conversion (somatic cell DNA recombination)\tdarwinism (Natural Phenomenon or Process)\tundifferentiated carcinoma of anal canal (Carcinoma of anal canal)\tprostanoid EP1 receptor binding (Molecular Function)\tSIQ02-I Thought About Writing a Will (Intellectual Product)", + "output": "SIQ02-I Thought About Writing a Will (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-naphthoyl-CoA + OH- = 2-naphthoate + CoASH.\nConcepts: Breast Cancer pN0(i+) TNM Finding v6 (Finding)\tHousehold Management (Daily or Recreational Activity)\tolivocochlear bundle (Pons part)\t2-naphthoate CoA-transferase activity (Molecular Function)\tPositive Romberg sign (Finding)", + "output": "2-naphthoate CoA-transferase activity (Molecular Function)" + }, + { + "input": "Definition: Spondyloepimetaphyseal disorder described as a rare primary bone dysplasia disorder with characteristics of normal birth length with early postnatal growth deficiency resulting in severe disproportionate short stature (with short trunk and limbs), severe genu varum, flexion contractures in the hips and lumbar hyperlordosis. Radiological findings reveal platyspondyly with central indentation of vertebral endplates, progressive and severe epimetaphyseal abnormalities that primarily affect the lower limbs and include very small, irregular proximal femoral and knee epiphyses, severe coxa vara, delayed ossification of proximal femoral epiphyses and irregular distal femoral and proximal tibial metaphyses.\nConcepts: strengthening exercises (Physical therapy)\tHFE2 (Gene or Genome)\tTherapeutic Insulin (Amino Acid, Peptide, or Protein)\tSpondyloepimetaphyseal dysplasia Isidor type (Disease or Syndrome)\tDoxapram product (pyrrolidine)", + "output": "Spondyloepimetaphyseal dysplasia Isidor type (Disease or Syndrome)" + }, + { + "input": "Definition: Sclerosing Agent [EPC] described as a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.\nConcepts: iodine I 131 NM404 (Radioimmunoconjugates)\t1-Amino-2-hydroxyethane (Organic Chemical)\tregulation of transcription involved in lymphatic endothelial cell fate commitment (Genetic Function)\tAcupuncture Point Injection (Therapeutic or Preventive Procedure)\tFallopian Tube Cancer pTis TNM Finding v7 (Finding)", + "output": "1-Amino-2-hydroxyethane (Organic Chemical)" + }, + { + "input": "Definition: Hemodialysis described as actions performed to support the mechanical removal of waste products from the blood\nConcepts: Accentuation of Pulsatile Flow Artifact (Finding)\tBPRS 1988 Version - Disorientation (Intellectual Product)\tHemodialysis Care (Health Care Activity)\tMiddle Ear Incus Surgical Hooks (Surgical Hooks)\tmitral valve calcification (Disease or Syndrome)", + "output": "Hemodialysis Care (Health Care Activity)" + }, + { + "input": "Definition: Research Activity described as an interdisciplinary scientific approach to the study of complex interactions among biological, social, behavioral and environmental factors.\nConcepts: Approach, Biobehavioral (Behavioral Research)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media, Manual Test (IVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media)\tCancer Doctor Advised Quit Cigarette Smoking (Intellectual Product)\tZNF331 (Transcription Regulation Gene)\tNon-distal deletion 12q (Deletion of part of long arm of chromosome 12)", + "output": "Approach, Biobehavioral (Behavioral Research)" + }, + { + "input": "Definition: something described as this gene plays a role in neural differentiation and cell cycle regulation.\nConcepts: Procedure Kit/Trays, Sampling, Endoscopic Aspiration (Phlebotomy kit)\tlipase, endothelial (Gene or Genome)\tneogenin 1 (Membrane Protein Gene)\tOral Reconstituted Suspension Dosage Form (Oral Suspension)\tExcision Repair Cross-Complementing Family (Protein Family)", + "output": "neogenin 1 (Membrane Protein Gene)" + }, + { + "input": "Definition: Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of substance P receptor binding.\nConcepts: CAMERA, CINE, ENDOSCOPIC, WITHOUT AUDIO (Medical Device)\tstage IA breast cancer (Neoplastic Process)\tCaspase Recruitment Domain-Containing Protein 15 (Apoptosis Regulatory Proteins)\tEuropean Directorate for the Quality of Medicines and HealthCare Basic Dose Form (EDQM Health Care Terminology)\tdown regulation of neurokinin-1 receptor binding (Molecular Function)", + "output": "down regulation of neurokinin-1 receptor binding (Molecular Function)" + }, + { + "input": "Definition: something described as a regimen consisting of doxorubicin, paclitaxel and cyclophosphamide, administered on a sequential schedule and used in the adjuvant setting for the treatment of breast cancer.\nConcepts: Number of Letters Correct (Quantity)\tNontuberculous mycobacterial pulmonary infection (Opportunistic bacterial infection)\tA-T-C Regimen (Regimen Used to Treat Breast Carcinoma)\tRecurrent Childhood Pilocytic Astrocytoma (Childhood Pilocytic Astrocytoma)\tMyo-Inositol Measurement (Laboratory Procedure)", + "output": "A-T-C Regimen (Regimen Used to Treat Breast Carcinoma)" + }, + { + "input": "Definition: something described as the determination of the amount of cytomegalovirus IgG antibody present in a sample.\nConcepts: CMVIGGAB (Cytomegalovirus antibody assay)\tOtospongiosis syndrome (VERTIGINOUS SYNDROMES AND OTHER LABYRINTHINE DISORDERS)\tWriting (Clinical or Research Assessment Question)\tUreter Abscess (Abdominal Infection)\tLovegrass (Plant)", + "output": "CMVIGGAB (Cytomegalovirus antibody assay)" + }, + { + "input": "Definition: Organism Function described as any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production.\nConcepts: Fears (mood symptoms)\tdown regulation of interleukin-22 production (regulation of interleukin-22 production)\tRegio praesubicularis (Body Location or Region)\tmitochondrion-associated adherens complex (Cell Component)\tzinc import into synaptic vesicle (Molecular Function)", + "output": "down regulation of interleukin-22 production (regulation of interleukin-22 production)" + }, + { + "input": "Definition: Acetylcholinesterase Inhibitors described as the carbamate agent fenobucarb.\nConcepts: UPDRS - Complications of Therapy: Other Complications - Anorexia, Nausea, or Vomiting (Intellectual Product)\tpositive regulation of microtubule motor activity (regulation of microtubule motor activity)\tELF (Disease Grade Qualifier)\tFenobucarb (Organic Chemical)\tPhysiologic Monitor Docking/Charging Stations (Manufactured Object)", + "output": "Fenobucarb (Organic Chemical)" + }, + { + "input": "Definition: Stage II Testicular Cancer AJCC v6 and v7 described as stage IIB includes: (Any pT/TX, N2, M0, S0); (Any pT/TX, N2, M0, S1). pTX: Primary tumor cannot be assessed. N2: Metastasis with a lymph node mass more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, any one mass greater than 2 cm but not more than 5 cm in greatest dimension. M0: No distant metastasis. S0: Marker study levels within normal limits. S1: LDH less than 1.5 x N (N indicates the upper limit of normal for the LDH assay) and hCG less than 5,000 and AFP less than 1,000. (AJCC 6th and 7th eds.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C6365\" active clinical trials using this agent.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Thyroid Hormone, Triiodothyronine, Free (IVD Test Reagent/Kits, Immunoassay, Thyroid Hormone, Triiodothyronine)\tNervi Vascularis (Tissue Part)\tDrug resistance in micro-organisms (Drug resistance)\tGenus: Tunga (Hectopsyllidae)\tStage IIB Cancer of Testis (stage II testicular cancer)", + "output": "Stage IIB Cancer of Testis (stage II testicular cancer)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Has he/she had a loss of appetite?\nConcepts: Japanese language (Language spoken)\tup regulation of protein binding (Molecular Function)\tTympani, Scala (Body Part, Organ, or Organ Component)\tInsula terminalis tubercularis (Body Part, Organ, or Organ Component)\tNPI1-Loss of Appetite (Intellectual Product)", + "output": "NPI1-Loss of Appetite (Intellectual Product)" + }, + { + "input": "Definition: Biologically Active Substance described as protein Wnt-5b (359 aa, ~40 kDa) is encoded by the human WNT5B gene. This protein plays a role in the initiation of G protein-coupled receptor signaling.\nConcepts: Wnt-5b (Biologically Active Substance)\tAlkane (Saturated aliphatic hydrocarbon)\tNHP2P Gene Mutation (Gene Mutant)\tSoftware Maintenance (Functional Concept)\tKIAA1036 (Gene or Genome)", + "output": "Wnt-5b (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a question about whether when doctors ask a lot of questions about patient's background, they are prying too much into personal matters.\nConcepts: Baroreflex (Reflex action)\tFIHPT - familial isolated hyperparathyroidism (Disease or Syndrome)\tNormocytic Anemia (Hematological Disease)\tMixing, High Shear/Wet Milling (Laboratory Procedure)\tWhen doctors ask a lot of questions about a patient's background, they are prying too much into personal matters (Clinical or Research Assessment Question)", + "output": "When doctors ask a lot of questions about a patient's background, they are prying too much into personal matters (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Pelvic Neoplasms described as tumors or cancer of the URINARY TRACT in either the male or the female.\nConcepts: Postmarketing Surveillance (Medical Surveillance)\tOptimal Morphologic Response (Finding)\tProtocol Title (Intellectual Product)\tcoronary artery aneurysms (Cardio-vascular Findings: Heart)\tUrinary Tract Neoplasm (Urologic Diseases)", + "output": "Urinary Tract Neoplasm (Urologic Diseases)" + }, + { + "input": "Definition: Red Blood Cell Count measurement described as the determination of the number of Cabot rings present in a sample.\nConcepts: ROBO/SLIT signaling pathway involved in axon pathfinding (Molecular Function)\tHEREDITARY SENSORY AUTONOMIC NEUROPATHIES (Polyneuropathy)\tCABOT (Red Blood Cell Count measurement)\tBP-Cx1-Platinum Complex BP-C1 (Platinum Antineoplastic Compound)\tB-Cell CLL/Lymphoma 9-Like Gene (Transcription Regulation Gene)", + "output": "CABOT (Red Blood Cell Count measurement)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the systematic study of how genetic information or GENOMICS translates into biochemical, metabolic and morphological traits of an organism.\nConcepts: Phenomics (Computational Biology)\tEmergency service personnel (Professional or Occupational Group)\tSuture Cutters (Cutter)\tCutaneous Burkitt Lymphoma (Burkitt Lymphoma)\tE. coli Infections (Disease or Syndrome)", + "output": "Phenomics (Computational Biology)" + }, + { + "input": "Definition: Intellectual Product described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes - During the past month, I have been: Worrying about my teen's low blood sugars when he/she is away from home.\nConcepts: 2: 165303867-165174840 (Chromosome 2 Physical Location)\tPituitary ACTH-Secreting Adenoma (Adenoma)\tDistress Score 5 (Distress Score Visual Analogue Scale)\tDDS02-Low Blood Sugars Away From Home (Intellectual Product)\t46,XX SEX REVERSAL, SRY-POSITIVE (Disorders of Sex Development)", + "output": "DDS02-Low Blood Sugars Away From Home (Intellectual Product)" + }, + { + "input": "Definition: something described as a rare autosomal recessive distal hereditary motor neuropathy with characteristics of slowly progressive muscular weakness, hypotonia and atrophy of the lower limbs, more pronounced distally, leading to paralysis, and loss of tendon reflexes. Additional features may include pes cavus and mild dysphonia. The upper limbs are relatively spared. There is evidence this disease is caused by homozygous mutation in the DNAJB2 gene on chromosome 2q35.\nConcepts: pyramidal layer of the piriform area (Body Location or Region)\tHER2-HER3 signaling pathway (ERBB3 signaling pathway)\tselenocystathionine gamma-lyase activity (carbon-sulfur lyase activity)\tYoung adult-onset distal hereditary motor neuropathy (Disease or Syndrome)\tpaspalinine synthase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "Young adult-onset distal hereditary motor neuropathy (Disease or Syndrome)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 38 of the coding sequence of the NRAS gene where guanine has been mutated to thymine.\nConcepts: lymphatic endothelial cell migration (Cell Function)\tNRAS NM 002524.4:c.38G>T (NRAS Exon 2 Mutation)\tNervous System Mercurialism (Injury or Poisoning)\tStick Dosage Form Category (Biomedical or Dental Material)\tRNA polymerase I preinitiation complex assembly (Molecular Function)", + "output": "NRAS NM 002524.4:c.38G>T (NRAS Exon 2 Mutation)" + }, + { + "input": "Definition: Antineoplastic Protein Inhibitor described as a designed ankyrin repeat proteins (DARPin)-based agent targeting vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF), with potential antiangiogenic and antineoplastic activities. Compared to antibodies, DARPins are small in size, have favorable pharmacokinetics and allow for both high affinity binding and efficacy. Upon administration, the VEGF/HGF-targeting DARPin MP0250 binds to and inhibits both HGF and VEGF. This prevents HGF- and VEGF-mediated signaling, and inhibits the growth of HGF/VEGF-overexpressing tumor cells. This agent also prevents osteolysis, due to the inhibitory effect on HGF signaling. HGF and VEGF are overexpressed in a variety of cancer cell types and are associated with increased cell proliferation, migration and adhesion.\nConcepts: VEGF/HGF-targeting DARPin MP0250 (Antineoplastic Protein Inhibitor)\tStorageEquipment.dimensionTwoLabel (Intellectual Product)\tMIR197 Pre-miRNA (pre-miRNA)\tcisternal maturation (intra-Golgi vesicle-mediated transport)\tVACAD (Therapeutic or Preventive Procedure)", + "output": "VEGF/HGF-targeting DARPin MP0250 (Antineoplastic Protein Inhibitor)" + }, + { + "input": "Definition: envenomation resulting in modulation of process in other organism described as a process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism.\nConcepts: Hodgkin's disease, NOS of spleen (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE HEMATOPOIETIC AND IMMUNE SYSTEMS)\temdr (Psychotherapy)\tdevelopment kidney (Histogenic Process)\tEyelid Carcinoma pT3 TNM Finding v8 (Eyelid Carcinoma Pathologic Primary Tumor TNM Finding v8)\tenvenomation resulting in regulation of blood coagulation in other organism (envenomation resulting in modulation of process in other organism)", + "output": "envenomation resulting in regulation of blood coagulation in other organism (envenomation resulting in modulation of process in other organism)" + }, + { + "input": "Definition: Regulation or Law described as the branch of pharmacokinetics that studies the process by which two or more drugs in a system are absorbed, distributed, metabolized, and eliminated by the body.\nConcepts: Paced Tapping (Functional assessment)\tPNCA3 Biallelic Gene Inactivation (Cell or Molecular Dysfunction)\tPrimary Pulmonary Diffuse Large B-Cell Lymphoma (Diffuse Large B-Cell Lymphoma)\tPHENYLKETOURIA (Nutritional and Metabolic Diseases)\tPHARMACOKINETIC DRUG INTERACTIONS (Study Reports: Pharmacokinetics)", + "output": "PHARMACOKINETIC DRUG INTERACTIONS (Study Reports: Pharmacokinetics)" + }, + { + "input": "Definition: something described as determines the patient's pulmonary system history and current function of the respiratory tract.\nConcepts: Pressure, Portal (Venous Blood Pressure)\tAssesses baseline respiratory status (Physiologic Responses)\tsupramammillary nucleus, medial part (Body Part, Organ, or Organ Component)\tPOF (Menopause finding)\tGlucose-6-phosphate transport defect (Glycogen Storage Disease)", + "output": "Assesses baseline respiratory status (Physiologic Responses)" + }, + { + "input": "Definition: Pathological Dilatation described as dilated tortuous vein, usually in subcutaneous tissues of the leg; incompetency of venous valves is associated.\nConcepts: Conjugated Linoleic Acids (Pharmacologic Substance)\tGlucosidase Inhibitor (Enzyme Inhibitor Drugs)\tNuclear Shapes, Cell (Qualitative Concept)\tVaricose Veins (Cardiovascular finding)\tIncreased CSF tyrosine concentration (Finding)", + "output": "Varicose Veins (Cardiovascular finding)" + }, + { + "input": "Definition: something described as a cardiopulmonary bypass in-line blood gas sensor is a transducer that measures the level of gases in the blood.\nConcepts: CTCAE Grade 1 Gastritis (Gastritis, CTCAE)\tSENSOR, BLOOD-GAS, IN-LINE, CARDIOPULMONARY BYPASS (Medical Device)\tCHART-SF Interview Version - Hours of Recreational Activities per Week (Intellectual Product)\tSIQR (Intellectual Product)\tNYHACLS (Finding)", + "output": "SENSOR, BLOOD-GAS, IN-LINE, CARDIOPULMONARY BYPASS (Medical Device)" + }, + { + "input": "Definition: something described as deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.\nConcepts: Extraocular Muscle Paresis, CTCAE (Finding)\tSoftware, Information System (Computer software)\tPerson.educationLevelCode (Education Level Code)\tPrecuneus Cortices (Body Part, Organ, or Organ Component)\tdisorder; growth (Pathologic Function)", + "output": "disorder; growth (Pathologic Function)" + }, + { + "input": "Definition: Procedure with a clinical finding focus described as based on current knowledge of the Patient Self-Determination Act (e.g., the living will, power of attorney for health care, do not resuscitate, informed consent, organ procurement) provides a copy of resources/referral related to the Patient Self-Determination Act.\nConcepts: 12: 120921747-120962668 (Chromosome 12 Physical Location)\tPlanned Activity Repeat Frequency Range Max Code (Intellectual Product)\tProvides information and explains Patient Self-Determination Act (Preoperative education including family and support persons)\tChudley Lowry syndrome (Mental Retardation)\tMyeloid and Lymphoid Neoplasms with t(8;9)(p22;p24.1);PCM1-JAK2 (Neoplastic Process)", + "output": "Provides information and explains Patient Self-Determination Act (Preoperative education including family and support persons)" + }, + { + "input": "Definition: something described as terminology related to the non-clinical cardiovascular test code codelist.\nConcepts: SEND Cardiovascular Test Code (CDISC SEND Terminology)\tCOWS1-Anxiety or Irritability (COWS Questionnaire Question)\tPediatric Central Nervous System Embryonal Carcinoma (Childhood Embryonal Carcinoma)\tCHAPTER 8 FUNCTIONS OF THE SKIN AND RELATED STRUCTURES (BODY FUNCTIONS)\tEBV-Related Non-Hodgkin's Lymphoma (Neoplastic Process)", + "output": "SEND Cardiovascular Test Code (CDISC SEND Terminology)" + }, + { + "input": "Definition: Body position described as posture while lying with the head lower than the rest of the body. Extended time in this position is associated with temporary physiologic disturbances.\nConcepts: Pix liquida homeopathic preparation (Pharmacologic Substance)\tIVD Test Reagent/Kits, Immunoassay, Calibration, Endocrine Hormone (IVD Test Reagent/Kits, Immunoassay, Calibration)\tHead-Down Tilt (Spatial Concept)\tupregulation of cellular response to tunicamycin (positive regulation of cellular process)\tcellular response to HGF stimulus (Cell Function)", + "output": "Head-Down Tilt (Spatial Concept)" + }, + { + "input": "Definition: Australasian country described as an archipelago in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand.\nConcepts: Change in Uterine Shape (Finding related to pregnancy)\tRegressing Nevus (Benign melanocytic nevus)\tBTF2-p34 (GTF2H3 gene)\tOrchidometer (Device associated with charts)\tTON (Polynesia)", + "output": "TON (Polynesia)" + }, + { + "input": "Definition: Disease or Syndrome described as complete blindness due to corneal opacities, difficult mastication due to temporomandibular fusion and anomalies of the arms. Micrognathia, shortening and bowing of the forearm, ulnar deviation and bowed radius, short fibula, genu valgum and coxa vara have been reported. Intelligence is normal. The causative gene has not yet been identified. Autosomal dominant inheritance has been suggested.\nConcepts: Lap Band Surgery (Therapeutic or Preventive Procedure)\tHospital Communication/Entertaining Systems (Hospital Communication Systems)\tADL03-Select First Clothes for the Day (ADCS-ADL MCI Questionnaire Question)\tOMM (ophthalmomandibulomelic) syndrome (Multiple malformation syndrome with facial-limb defects as major feature)\taryl-aldehyde:NADP+ oxidoreductase (aldehyde dehydrogenase (NADP+) activity)", + "output": "OMM (ophthalmomandibulomelic) syndrome (Multiple malformation syndrome with facial-limb defects as major feature)" + }, + { + "input": "Definition: US State described as state bounded on the north by Michigan and Lake Erie, on the east by Ohio River and Pennsylvania, on the south by Ohio River, and on the west by Indiana.\nConcepts: Set of parabrachial nuclei (Structure of tegmental portion of pons)\tIVD Test Reagent/Kits, Immunoassay, Endocrine Hormone, Insulin-Like Growth Factor I (IVD Test Reagent/Kits, Immunoassay, Endocrine Hormone)\tOhio (Region of United States of America)\tCrest (Anatomical line)\tCalibration Date (Date in time)", + "output": "Ohio (Region of United States of America)" + }, + { + "input": "Definition: something described as cerebellar long-term depression (LTD), thought to be a molecular and cellular basis for cerebellar learning, is a process involving a decrease in the synaptic strength between parallel fiber (PF) and Purkinje cells (PCs) induced by the conjunctive activation of PFs and climbing fiber (CF). Multiple signal transduction pathways have been shown to be involved in this process. Activation of PFs terminating on spines in dendritic branchlets leads to glutamate release and activation of both AMPA and mGluRs. Activation of CFs, which make multiple synaptic contacts on proximal dendrites, also via AMPA receptors, opens voltage-gated calcium channels (VGCCs) and causes a generalized influx of calcium. These cellular signals, generated from two different synaptic origins, trigger a cascade of events culminating in a phosphorylation-dependent, long-term reduction in AMPA receptor sensitivity at the PF-PC synapse. This may take place either through receptor internalization and/or through receptor desensitization.\nConcepts: video-assisted resection (Therapeutic or Preventive Procedure)\tLong-term depression (Functional Concept)\tlow angle X ray diffraction analysis (Crystallography, X-Ray)\tconstruction (Surgical repair)\tmannosylglycerate transport (Molecular Function)", + "output": "Long-term depression (Functional Concept)" + }, + { + "input": "Definition: myeloid cell homeostasis described as the process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.\nConcepts: TNF/Stress Related Signaling (Cell Function)\tmast cell homeostasis (myeloid cell homeostasis)\tdown-regulation of NK T cell proliferation (regulation of NK T cell proliferation)\tmammary gland cord morphogenesis (epithelial tube morphogenesis)\tguanidine HCl (guanidine)", + "output": "mast cell homeostasis (myeloid cell homeostasis)" + }, + { + "input": "Definition: something described as complex that possesses guanylate cyclase activity and is not bound to a membrane.\nConcepts: circumscribed; cerebellar sarcoma (Malignant Glioma)\tguanylate cyclase complex location, soluble (Cell Component)\tNoninvasive ventilation (Respiration, Artificial)\tintegrated fitness assessment (Physiologic Testing)\tEosinophil Carcinoma (Experimental Organism Neoplasm)", + "output": "guanylate cyclase complex location, soluble (Cell Component)" + }, + { + "input": "Definition: WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Interviewer - Because of your health condition, in the past 30 days, how much difficulty did you have in: Doing your most important household tasks well?\nConcepts: RYK (Receptor Protein-Tyrosine Kinases)\tRepresentation (Action)\tanion:anion antiporter activity (solute:anion antiporter activity)\tWD5D5 2 (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tMononucleotide and Dinucleotide Marker Panel (Laboratory Procedure)", + "output": "WD5D5 2 (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: Physiologic Function described as nonsusceptibility to the invasive or pathogenic effects of foreign bacteria or to the toxic effect of bacterial antigenic substances.\nConcepts: bactericidal immunity (microorganism immunology)\tHave Pain Increase with Activity (Intellectual Product)\tHartmann's solution (Agent Affecting Blood or Body Fluid)\tOrtho-Bionomy(TM) each 15 minutes (Therapeutic or Preventive Procedure)\tMaidong (Pharmacologic Substance)", + "output": "bactericidal immunity (microorganism immunology)" + }, + { + "input": "Definition: something described as physical location of CD58_Gene\nConcepts: 1: 116825645-116769199 (Spatial Concept)\tvisible (General Qualifier)\tADL03-Subscore for Items 11 to 12d (Intellectual Product)\tBone Morphogenetic Protein 2B (Bone Morphogenetic Proteins)\tFollow-Up Form Completion Outcome Measure of Success Not Applicable (Finding)", + "output": "1: 116825645-116769199 (Spatial Concept)" + }, + { + "input": "Definition: Molecular Function described as g-protein coupled receptors (GPCRs) transduce a variety of signals from the extracellular environment across the plasma membrane. One of the common signaling systems utilized by GPCRs activates protein kinase C (PKC), a ubiquitous family of serine/threonine protein kinases. The pathway leading to PKC activation starts with a class of GPCRs that interact with and activate Gq G-proteins when the receptor has agonist ligand bound. GPCRs that act through Gq include some muscarinic acetylcholine receptors, many peptide receptors, and the 5-HT2 serotonin receptors. Activated Gq with GTP bound activates its downstream target phospholipase C (PLC) to hydrolyze the membrane lipid PIP2, producing IP3 and diacylglycerol (DAG). IP3 is water-soluble and diffuses through the cytoplasm to the ER, where it binds to and opens a calcium channel, releasing calcium stores from inside the ER into the cytoplasm. Calcium alters many cellular processes, in part by binding to regulatory proteins such as calmodulin and calcineurin. The interaction of both DAG and calcium with PKC activates its kinase activity and the phosphorylation of many different protein targets alters their activity. The involvement of PKC in cellular proliferation and the cell cycle is indicated by the activity of tumor promoters like phorbol esters as PKC activators.\nConcepts: antiretrovirals elvitegravir (Medicinal product categorized by structure)\tCongenital enterocyte heparan sulfate deficiency (Congenital Abnormality)\tZygomatic Arch Bone Awls (Medical Device)\tregulation of leukocyte cell adhesion (Cell Function)\tProtein Kinase C Activation Pathway (Protein Activation Pathway)", + "output": "Protein Kinase C Activation Pathway (Protein Activation Pathway)" + }, + { + "input": "Definition: Disease of Skin and Appendages described as a benign or malignant neoplasm that arises from the hair follicles, sebaceous glands, or sweat glands.\nConcepts: Antithrombin III Antigen (Laboratory Procedure)\tMembrane Transport Protein (Carrier Proteins)\tNeoplasm of adenexa of skin (Disease of Skin and Appendages)\tDRRI1-F: Exposed to Diesel/Fuel on Skin (DRRI-2 Questionnaire Question)\tCycle day (Numbers)", + "output": "Neoplasm of adenexa of skin (Disease of Skin and Appendages)" + }, + { + "input": "Definition: Non-Human Protein described as proteins found in any species of yeast.\nConcepts: Congenital Hydrocephalus (Congenital and developmental anomalies of the nervous system)\tyeast protein (Amino Acid, Peptide, or Protein)\tLeuconostocaceae (Lactobacillales)\tProtozoan Infection, Animal (Disease or Syndrome)\tegg yolk (Egg Food Product)", + "output": "yeast protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as a powered environmental control system is an AC- or battery-powered device intended for medical purposes that is used by a patient to operate an environmental control function. Examples of environmental control functions include the following: to control room temperature, to answer a doorbell or telephone, or to sound an alarm for assistance.\nConcepts: IPAQ Long Last 7 Days Telephone Format Version - Days Walk in Your Leisure Time (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tregulation of SODS (regulation of oxidoreductase activity)\tSYSTEM, ENVIRONMENTAL CONTROL, POWERED (Medical Device)\tAs Collected Indicator (Qualitative Concept)\tPathologic Stage III Gastric Carcinoma AJCC v8 (Neoplastic Process)", + "output": "SYSTEM, ENVIRONMENTAL CONTROL, POWERED (Medical Device)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) In the past 4 weeks, did the subject talk about current events?\nConcepts: ENRAGE (Laboratory Procedure)\tFailure, Prosthesis (Phenomenon or Process)\tADCS-ADL - Talk About Current Events (Intellectual Product)\tObsessive-compulsive traits (Finding)\tLess than 75 Percent of the Time (Clinical or Research Assessment Answer)", + "output": "ADCS-ADL - Talk About Current Events (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of low-density lipoprotein particle receptors.\nConcepts: down-regulation of low-density lipoprotein receptor biosynthetic process (Cell Function)\tSynaptic Junction Pathway (Cell Differentiation or Development Pathway)\tH2BC12 wt Allele (Gene or Genome)\turacil nucleoside (Nucleic Acid, Nucleoside, or Nucleotide)\tCHLORDECONE (Special Chemical Categories)", + "output": "down-regulation of low-density lipoprotein receptor biosynthetic process (Cell Function)" + }, + { + "input": "Definition: violaceol I metabolic process described as the chemical reactions and pathways resulting in the formation of violaceol I.\nConcepts: Emerging Technologies (Qualitative Concept)\tsecretion process (Biological Transport)\tarea 27 of Brodmann (Body Location or Region)\tviolaceol I anabolism (Molecular Function)\tTractus interstitiospinalis (Tract of spinal cord)", + "output": "violaceol I anabolism (Molecular Function)" + }, + { + "input": "Definition: something described as a benign sex cord-stromal neoplasm that arises from the testis or ovary and is composed of a mix of cell types.\nConcepts: FACT-P Version 4 - Certain Parts of Body Experience Pain (Intellectual Product)\tIPA0304B (Intellectual Product)\tExperimental Organism Benign Mixed Sex Cord Stromal Tumor (Experimental Organism Neoplasm)\tPIT Score 1 (Peripheral T-cell Lymphoma Prognostic Index Score)\tNAD(P)+ transhydrogenase complex location (protein-containing complex)", + "output": "Experimental Organism Benign Mixed Sex Cord Stromal Tumor (Experimental Organism Neoplasm)" + }, + { + "input": "Definition: DNA repair protein described as DNA repair protein RAD51 homolog 4 (328 aa, ~35 kDa) is encoded by the human RAD51D gene. This protein plays a role in homologous recombination repair.\nConcepts: Testicular Cancer pT3 TNM Finding v7 (Finding)\tStage IIA Fallopian Tube Carcinoma AJCC v8 (Neoplastic Process)\tDNA Repair Protein RAD51 Homolog 4 (DNA repair protein)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Listeria Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)\tTP53 Protein Variant (Cell or Molecular Dysfunction)", + "output": "DNA Repair Protein RAD51 Homolog 4 (DNA repair protein)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a deletion of the thymine nucleotide at position 5946 of the coding sequence of the BRCA2 gene.\nConcepts: DC/MM Fusion Vaccine (Pharmacologic Substance)\tdown regulation of chemokine production (Organism Function)\tacireductone dioxygenase (Ni2+-requiring) activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tOrthodontic extraoral headgear (Orthodontic Appliances)\tFANCD1 c.5946delT (Cell or Molecular Dysfunction)", + "output": "FANCD1 c.5946delT (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Oligonucleotides described as an antisense oligonucleotide modified to be more stable than RNA. While morpholinos have standard nucleic acid bases, those bases are bound to morpholine rings instead of deoxyribose rings and linked through phosphorodiamidate groups instead of phosphates. Morpholinos are used to inhibit translation or splicing of specific, complementary mRNAs.\nConcepts: PMO Oligomers (Oligonucleotides)\tDNA Intrastrand Crosslinking (DNA Crosslinking)\tYENDNA (Microbiology procedure)\tSequences, Terminal Repeat (Nucleic Acid, Nucleoside, or Nucleotide)\tclinical trial information (Intellectual Product)", + "output": "PMO Oligomers (Oligonucleotides)" + }, + { + "input": "Definition: Growth Chart Percentile described as an indication that an individual ranks the same or more than 10 percent of the reference population for a given attribute.\nConcepts: 10th Growth Percentile (Growth Chart Percentile)\tEORTC QLQ-C30 Version 3 - Have You Felt Nauseated (Intellectual Product)\turethral dilators (Dilator)\tIVD Test Reagent/Kits, Clinical Chemistry, Enzyme, Angiotensin Converting (IVD Test Reagent/Kits, Clinical Chemistry, Enzyme)\tLip, Cleft (Cleft lip or lips)", + "output": "10th Growth Percentile (Growth Chart Percentile)" + }, + { + "input": "Definition: West Slavic Language described as a West Slavic language belonging to the Lechitic subgroup that is native to Poland.\nConcepts: therapy-related toxicity (Finding)\tSulfur product (Dermatologic Agents)\tKashubian Language (Language)\tGenus Myxococcus (Myxococcaceae)\tH Factor 1 (Amino Acid, Peptide, or Protein)", + "output": "Kashubian Language (Language)" + }, + { + "input": "Definition: Medical Device described as covers designed to sheathe or encase clinical thermometers, providing a sanitary protective barrier to prevent cross-contamination during temperature taking. Thermometer covers are disposable and are made of thin, flexible, transparent plastic film. Different sizes of thermometer covers are available for either digital or mercury thermometers that are used for oral, rectal, or axillary temperature taking, and for thermometers sized for adult or pediatric use.\nConcepts: Rupicapras (Mammal)\tNPI1-Delusions Frequency (NPI Questionnaire Question)\tThermometer Covers (Medical Device)\tKnowledge: Personal Safety (Knowledge level: health promotion)\tPheochromocytoma and Paraganglioma pM1b TNM Finding v8 (Pheochromocytoma and Paraganglioma pM1 TNM Finding v8)", + "output": "Thermometer Covers (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as low-density lipoprotein receptor-related protein 1B (4599 aa, ~515 kDa) is encoded by the human LRP1B gene. This protein plays a role in the metabolism of low density lipoproteins.\nConcepts: yes/no/not applicable (Clinical or Research Assessment Answer)\tmixed; meningioma (Neoplastic Process)\tNDC ML (National Drug Code Unit of Measure)\tLow-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor (Amino Acid, Peptide, or Protein)\tnicotinamide nucleotide synthesis from niacinamide (nicotinamide metabolic process)", + "output": "Low-Density Lipoprotein Receptor-Related Protein-Deleted In Tumor (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the amino acid residue at position 469 in the serine/threonine protein kinase B-raf protein where glycine has been replaced by arginine.\nConcepts: 46 (Body Location or Region)\t2pter-p12 (Cell Component)\tNanofiber (Nanostructured Materials)\tBRAF NP 004324.2:p.G469R (BRAF Protein Variant)\tuIU/mL/(mg/kg) (Quantitative Concept)", + "output": "BRAF NP 004324.2:p.G469R (BRAF Protein Variant)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate.\nConcepts: isocitrate dehydrogenase kinase activity (protein kinase activity)\tTreatment Episode Indicator (Conceptual Entity)\texcretion (Secretory AND/OR excretory function)\taneuploidies (Chromosome Aberrations)\tInclusion Cyst (Skin Histology)", + "output": "isocitrate dehydrogenase kinase activity (protein kinase activity)" + }, + { + "input": "Definition: Allyl-S Compound described as an allyl-S compound with the structure C=CCSSSCC=C.\nConcepts: median fin development (Organism Function)\tCarcinoma of the Lacrimal Gland Pathologic Distant Metastasis TNM Finding v7 (Carcinoma of the Lacrimal Gland Pathologic TNM Finding v7)\tFollicular dendritic cell sarcoma (Histiocytosis)\tMULTIPLEXED OPSONOPHAGOCYTIC KILLING ASSAY (Laboratory Procedure)\tDiallyl Trisulfide (Pharmacologic Substance)", + "output": "Diallyl Trisulfide (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a rare cutaneous paraneoplastic disease characterised by the presence of excessive lanugo-type hair on the glabrous skin of face, neck, trunk and limbs that can be associated with additional clinical features such as burning glossitis, papillary hypertrophy of the tongue, diarrhoea, dysgeusia, and/or weight loss. It is associated with lymphoma or cancer of the gastrointestinal system, urinary tract, lung, breast, uterus or ovary.\nConcepts: estazolam (Sedatives)\tDnaA-DiaA-DNA complex location (primosome complex)\tGDS - Think Wonderful to Be Alive (Intellectual Product)\tMalignant down (Paraneoplastic Syndromes)\tbranching involved in mammary gland cord morphogenesis (Organism Function)", + "output": "Malignant down (Paraneoplastic Syndromes)" + }, + { + "input": "Definition: furuncle described as hordeola externa are acute purulent infections affecting the sebaceous glands of Zeis or the apocrine sweat glands of Moll, often caused by staphylococcus infections. In contrast to chalazia, hordeola are extremely painfull and can cause extreme local swelling.\nConcepts: IVD Panels, Human Genetics, Metabolic Disorder, Albinism (IVD Panels, Human Genetics, Metabolic Disorder)\tGrade 3 Intraoperative Renal Injury, CTCAE (Finding)\tfuruncles on eyelid (Inflammation of specific body systems)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 3 Major Internal Structural Defect (GAIA Major Congenital Anomalies Level of Diagnostic Certainty)\t2-Mercaptoethanesulfonic Acid Sodium Salt (Alkanesulfonates)", + "output": "furuncles on eyelid (Inflammation of specific body systems)" + }, + { + "input": "Definition: something described as viscera located in the pelvis. Examples: There is only one set of pelvic viscera.\nConcepts: Female pelvic viscera (Pelvic viscus)\tsubstrate-bound cell migration, cell contraction (Cell Function)\tUPDRS - Motor Examination: Rigidity Upper Extremity, Left (Intellectual Product)\tDouillard Regimen (Therapeutic or Preventive Procedure)\tCyst of breast, NOS (Cyst)", + "output": "Female pelvic viscera (Pelvic viscus)" + }, + { + "input": "Definition: something described as the determination of the amount of apolipoprotein AII present in a sample.\nConcepts: sodium-translocating F-type ATPase activity (sodium ion transmembrane transporter activity)\tApolipoprotein A-II (Laboratory Procedure)\tregulation of amino acid import across plasma membrane (regulation of amino acid transmembrane transport)\tThyroid antagonists (Hormone Antagonists)\tdrinking (Eating, drinking and/or feeding function)", + "output": "Apolipoprotein A-II (Laboratory Procedure)" + }, + { + "input": "Definition: something described as no tumor in either eye is greater than 3 mm in largest dimension or located closer than 1.5 mm to the optic nerve or fovea.\nConcepts: Propanamide, N-((4-(5-methyl-3-phenyl-4- isoxazolyl)phenyl)sulfonyl)-, Sodium Salt (Isoxazoles)\tEIF2AK4 wt Allele (Gene or Genome)\tAP-4 (Gene or Genome)\tRetinoblastoma cT1a TNM Finding v7 (Finding)\tIRON DEFICIENCY (Other Finding)", + "output": "Retinoblastoma cT1a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Stromal Change described as a morphologic finding that indicates the presence of reactive fibrotic stroma in a tissue sample.\nConcepts: Benign Tumor of Nipple (Breast and nipple neoplasms benign)\tFibrotic Stroma Formation (Stromal Change)\tBSTESTCD (CDISC SDTM Terminology)\tselenate adenylyltransferase activity (Molecular Function)\tDeep facial vein (Body Part, Organ, or Organ Component)", + "output": "Fibrotic Stroma Formation (Stromal Change)" + }, + { + "input": "Definition: something described as to evaluate and screen Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) donors for communicable disease risks.\nConcepts: Screen (Health Care)\tMIR32 Pre-miRNA (pre-miRNA)\tCav3.1 (CACNA1G gene)\tCarcinoma of the Conjunctiva pT1 TNM Finding v7 (Finding)\tArbitrary Fluorescence Unit (Fluorescence Units)", + "output": "Screen (Health Care)" + }, + { + "input": "Definition: positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus described as any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a maltose stimulus.\nConcepts: mitogen (Pharmacologic Substance)\tglypican 3-specific chimeric antigen receptor-expressing autologous T cells (Cell)\tSagittal Sinus (Body Part, Organ, or Organ Component)\tup-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus (Genetic Function)\tNUP98-RAP1GDS1 Fusion Gene (Gene or Genome)", + "output": "up-regulation of transcription from RNA polymerase II promoter involved in cellular response to maltose stimulus (Genetic Function)" + }, + { + "input": "Definition: Cathepsins described as a cysteine protease that is highly expressed in OSTEOCLASTS and plays an essential role in BONE RESORPTION as a potent EXTRACELLULAR MATRIX-degrading enzyme.\nConcepts: transforming growth factor beta activated kinase 1 complex location (Cell Component)\tMole, unit of measurement (Base Unit of International System of Units)\tCathepsin K (Hydrolase)\tCDISC Questionnaire Bladder Control Scale Test Name Terminology (CDISC Questionnaire Terminology)\tregulation of sterol transport (regulation of lipid transport)", + "output": "Cathepsin K (Hydrolase)" + }, + { + "input": "Definition: Gyrus of limbic lobe described as a cortical region or convolution on the dorsal surface of each cerebral hemisphere overlying the hippocampus between the hippocampal and collateral fissures, which includes the entorhinal cortex, the temporal cortical fields, and is considered part of the limbic system.\nConcepts: HLA-Dw (Amino Acid, Peptide, or Protein)\tVectors, Disease (Infectious agent)\tGyrus Hippocampus (Gyrus of brain)\tDESULFOVIBRIO (Deltaproteobacteria)\tNux vomica / poison nut (Pharmacologic Substance)", + "output": "Gyrus Hippocampus (Gyrus of brain)" + }, + { + "input": "Definition: Pharmacologic Substance described as a liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2388\" active clinical trials using this agent.\nConcepts: Product containing cytarabine liposome (pyrimidine analog)\tSix to Ten Active Hours (Clinical or Research Assessment Answer)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TK2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tPhycobilisome (Light-Harvesting Protein Complexes)\tVulvar Cancer pN1b TNM Finding v7 (Finding)", + "output": "Product containing cytarabine liposome (pyrimidine analog)" + }, + { + "input": "Definition: something described as physical location of CTBP1_Gene\nConcepts: PPI2458 (Endothelial Cell Inhibitor)\t4: 1232621-1195118 (Spatial Concept)\tADTC01-Alcohol Drinks on a Typical Day (AUDIT-C Questionnaire Question)\tClinical dementia rating scale (neuropsychological testing battery)\tKIAA0214 (MFN2 gene)", + "output": "4: 1232621-1195118 (Spatial Concept)" + }, + { + "input": "Definition: Arrhythmia by ECG Finding described as continued electrical rhythmicity of the heart in the absence of effective mechanical function.\nConcepts: Electromechanical Dissociation by ECG Finding (Ventricular arrhythmias and cardiac arrest)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 1 Gestational Hypertension (GAIA Preeclampsia Level of Diagnostic Certainty)\tCalcarea silicata / calcium silicate (Pharmacologic Substance)\tscotland (Geographic Area)\tcell-cell signalling involved in pronephros development (Cell Function)", + "output": "Electromechanical Dissociation by ECG Finding (Ventricular arrhythmias and cardiac arrest)" + }, + { + "input": "Definition: Anatomical Abnormality described as any abnormality of the large intestine.\nConcepts: Nexin, Sorting (Amino Acid, Peptide, or Protein)\tFLJ38614 (CHD2 gene)\tAbnormality of the large intestine (Anatomical Abnormality)\tp38MAPK cascade (Molecular Function)\tLeft Kidney (Structure of left half of abdomen)", + "output": "Abnormality of the large intestine (Anatomical Abnormality)" + }, + { + "input": "Definition: beta-glucoside metabolic process described as the chemical reactions and pathways involving cyanidin 3-O-beta-D-glucoside.\nConcepts: Morgue (Health care facility)\tcyanidin 3-O-glucoside metabolic process (beta-glucoside metabolic process)\tHDL Particle Size (Laboratory Procedure)\tNon-Resectable Hepatocellular Carcinoma (Liver carcinoma)\tWPAI01-Absenteeism Score (Intellectual Product)", + "output": "cyanidin 3-O-glucoside metabolic process (beta-glucoside metabolic process)" + }, + { + "input": "Definition: something described as complete resection or reconstruction of injured organ/structure indicated; limiting self care ADL\nConcepts: C-X-C chemokine binding (chemokine binding)\tShort thorax (Ribs, sternum, clavicles, and scapulae)\tregulation of flagellated sperm motility (regulation of reproductive process)\tDining at a Restaurant (Intellectual Product)\tGrade 3 Intraoperative Head and Neck Injury, CTCAE (Finding)", + "output": "Grade 3 Intraoperative Head and Neck Injury, CTCAE (Finding)" + }, + { + "input": "Definition: something described as the directed movement of a motile cell in response to the presence of angiotensin.\nConcepts: BMP signalling pathway involved in spinal cord dorsal-ventral patterning (BMP Receptor Signaling Pathway)\tHow Much Bothered by Being Itchy (Clinical or Research Assessment Question)\tIPA0225D (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tchlorophyll a breakdown (chlorophyll catabolic process)\tangiotensin mediated chemotaxis (Cell Function)", + "output": "angiotensin mediated chemotaxis (Cell Function)" + }, + { + "input": "Definition: Female internal genitalia structure described as failure of oocytes to proceed through the stages of meiosis with stoppage at the first metaphase stage.\nConcepts: Small intestine (Structure of organ within abdomen proper cavity)\tOocyte arrest at metaphase I (Female internal genitalia structure)\tFeeling sad (Clinical or Research Assessment Question)\tC-SSRS Baseline/Screening Version - Interrupted Suicide Attempt (Intellectual Product)\tosteogenesis imperfecta (Congenital anomaly of skeletal bone)", + "output": "Oocyte arrest at metaphase I (Female internal genitalia structure)" + }, + { + "input": "Definition: regulation of gene expression, epigenetic described as any epigenetic process that stops, prevents or reduces the rate of gene expression.\nConcepts: negative regulation of gene expression, epigenetic (negative regulation of gene expression)\tHemoglobin E to Total Hemoglobin Ratio Measurement (Laboratory Procedure)\tSubgroup Code (Intellectual Product)\tIncrease or decrease in vitamin K content of the diet. Treatment for some coagulopathies. (Source: Nutrition Care Manual, Academy of Nutrition and Dietetics 2013). (Modified vitamin diet)\tbranching morphogenesis of an epithelial tube (morphogenesis of a branching epithelium)", + "output": "negative regulation of gene expression, epigenetic (negative regulation of gene expression)" + }, + { + "input": "Definition: something described as susceptible to a disorder that occurs after death of a significant other in which the experience of distress accompanying bereavement fails to follow normative expectations and manifests in functional impairment, which may compromise health.\nConcepts: Risk for complicated grieving (Coping responses)\tSnoN (Gene or Genome)\tTrilostano (Synthetic antiestrogen, NOS)\tOffice of Cancer Survivorship (Health Care Related Organization)\toxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor (oxidoreductase activity, acting on NAD(P)H)", + "output": "Risk for complicated grieving (Coping responses)" + }, + { + "input": "Definition: something described as the formation of the primary meristem or meristematic tissue that gives rise to the ground tissues.\nConcepts: MSQL1-Discouraged by Health Problems (MSQOL-54 Questionnaire Question)\tground meristem histogenesis (Organism Function)\tOsseous (Skeletal system)\tDouble-J Ureteral Catheters (Ureteral Catheters)\tScreen, X-Ray Intensifying (Medical Device)", + "output": "ground meristem histogenesis (Organism Function)" + }, + { + "input": "Definition: Device system described as a system designed to remove unwanted substances from water.\nConcepts: Water Purification System Device (Device system)\tST Elevated Myocardial Infarction (Disease or Syndrome)\tpeptide cross-linking via glycine oxazolecarboxylic acid (Molecular Function)\tGrade 2 Supraventricular Tachycardia, CTCAE (Supraventricular Tachycardia, CTCAE)\tNPI1-Stubborn (Intellectual Product)", + "output": "Water Purification System Device (Device system)" + }, + { + "input": "Definition: Radiation-Sensitizing Agents described as a gel-based formulation composed of a very dilute solution of hydrogen peroxide (H2O2) combined with hyaluronic acid (HA), with potential radiosensitizing activity. Upon intratumoral injection and slow-release (SR) of H2O2 from the gel, H2O2 releases oxygen and inactivates anti-oxidative enzymes, thereby increasing the oxygen concentration in the tumor environment, which increases the efficacy of radiotherapeutic treatment. HA increases viscosity of the formulation and allows for the SR of H2O2; as compared to the injection of H2O2 alone, the addition of HA decreases diffusion of H2O2 to surrounding areas and enhances intratumoral H2O2 concentration over an increased period of time. Hypoxic tumors show a decreased response to radiotherapy; thus, increasing oxygen content increases tumor response to radiotherapy.\nConcepts: Appendiceal Carcinoma Clinical Distant Metastasis TNM Finding v7 (Appendiceal Carcinoma Clinical TNM Finding v7)\tHydrogen Peroxide-hyaluronic Acid Tumor Injectable Formulation (Radiation-Sensitizing Agents)\tFoetal status: intrapartum (Finding)\tInner layer of eyeball (Neuroanatomy)\tInterleukin 8 Receptor Type A (CD Antigens)", + "output": "Hydrogen Peroxide-hyaluronic Acid Tumor Injectable Formulation (Radiation-Sensitizing Agents)" + }, + { + "input": "Definition: Recumbent body position described as an anterior recumbent body position whereby the person lies on its stomach and faces downward.\nConcepts: women's health (public health medicine)\tfissures lungs (Lung part)\tVaginal and Other Genital (Body Location or Region)\tPROTEIN-TYROSINE PHOSPHATASE, TYPE 4A, 3 (Non-Receptor Protein Tyrosine Phosphatase Gene)\tprone (Body position)", + "output": "prone (Body position)" + }, + { + "input": "Definition: cellular chemical homeostasis described as any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell.\nConcepts: Structural Biochemistry (Occupation or Discipline)\tcellular sphingolipid homeostasis (Cell Function)\tI feel a throat obstacle during swallowing (Intellectual Product)\tIntrapartal Care (Therapeutic or Preventive Procedure)\tgolden retrievers (Retriever)", + "output": "cellular sphingolipid homeostasis (Cell Function)" + }, + { + "input": "Definition: Head and Neck Precancerous Condition described as a premalignant pathologic process that affects the epithelial cells of the laryngeal mucosa.\nConcepts: methallyl chloride (Carcinogenic Chlorinated Hydrocarbon)\tImmersible Ergocycles (Bicycle exerciser)\tLaryngeal Premalignant Condition (Head and Neck Precancerous Condition)\tyeast protein (Non-Human Protein)\tdetermination self (Thesaurus of Psychological Index Terms)", + "output": "Laryngeal Premalignant Condition (Head and Neck Precancerous Condition)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: regulation of Na+ transport (regulation of metal ion transport)\tLymphoma, Nodular Histiocytic (Lymphoma/Leukemia by Kiel Classification)\tManagement, Change (Organizational Innovation)\tPaxillin (Adaptor Proteins, Signal Transducing)\tPhylum: Echinodermata (Sponges, Coelenterates and Echinoderms)", + "output": "regulation of Na+ transport (regulation of metal ion transport)" + }, + { + "input": "Definition: Medical Device described as liquid germicides with an active component of a quaternary ammonium compound (e.g., alkyl dimethyl benzyl ammonium chloride, alkyl didecyl dimethyl ammonium chloride, dialkyl dimethyl ammonium chloride) and are intended for killing and/or inactivating microorganisms (e.g., bacteria, fungi, viruses). Quaternary ammonium compound-based germicides typically are used in low-level disinfection of noncritical surfaces (e.g., floors, furniture, walls) and for disinfection of medical equipment that contacts intact skin.\nConcepts: Germicides, Liquid, Quaternary Ammonium Compound (Medical Device)\tKnodell Fibrosis Score (Disease Grade Qualifier)\tCalcification of trachea (respiratory obstructive disorders)\tpositive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity (Molecular Function)\tAbnormal cervical spine morphology (Abnormal vertebral morphology)", + "output": "Germicides, Liquid, Quaternary Ammonium Compound (Medical Device)" + }, + { + "input": "Definition: something described as a surgical specialty concerned with surgical treatment of the diseases of the urinary tract and urogenital system.\nConcepts: FTGRPID (Intellectual Product)\tCYCYSTIN (Laboratory Procedure)\tOccipital Encephaloceles (Anomalies of cerebrum)\tactivation of N',N'',N'''-triacetylfusarinine C formation (positive regulation of nitrogen compound metabolic process)\tUrological Surgery (Specialties, Surgical)", + "output": "Urological Surgery (Specialties, Surgical)" + }, + { + "input": "Definition: Finding described as personal actions to perform the most basic physical tasks and personal care activities independently with or without assistive device\nConcepts: Ochrobactrum anthropi Holmes et al. 1988 (Ochrobactrum)\tSelf-care: activities of daily living (Self Care outcome)\tmicrogram per meter squared (Non-SI unit of pressure)\tprimaryIndicator (Indicator)\tPolyethylene Glycol 1000 Cetyl Ether Cream (Organic Chemical)", + "output": "Self-care: activities of daily living (Self Care outcome)" + }, + { + "input": "Definition: Medical Device described as a contraceptive tubal occlusion device (TOD) and introducer is a device designed to close a fallopian tube with a mechanical structure, e.g., a band or clip on the outside of the fallopian tube or a plug or valve on the inside. The devices are used to prevent pregnancy.\nConcepts: cilium/flagellum motility (Cell Function)\tRehabilitation coordinator (Care coordinator)\tVALVE, TUBAL OCCLUSION (Medical Device)\tregulation of protein targeting to vacuolar membrane (regulation of protein targeting to membrane)\tN-(2-(4-chlorophenoxy)isobutyryl)-N-morpholinomethylurea (Fibrate Antilipidemic Agent)", + "output": "VALVE, TUBAL OCCLUSION (Medical Device)" + }, + { + "input": "Definition: something described as feline leukemia virus (FeLV) and feline sarcoma virus (FeSV) are both species of gammaretrovirus; FeLV causes leukemia, lymphosarcoma, immune deficiency, or other degenerative diseases in cats; FeSV is a recombinant feline leukemia viruses where part of the genome has been replaced by cellular oncogenes, unique to individuals and not transmitted naturally to other cats; FeSVs are replication defective and require FeLV to reproduce.\nConcepts: feline leukemia/sarcoma virus (Virus)\tDIABETES-ASSOCIATED PEPTIDE (Gene or Genome)\tCheerful mood [dup] (pleasurable emotion)\tGrade 4 Personality change (Finding)\tExtremely Interfering (Clinical or Research Assessment Answer)", + "output": "feline leukemia/sarcoma virus (Virus)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether or not an individual had any stretch marks over the past seven days.\nConcepts: Past Seven Days Any Stretch Marks (Clinical or Research Assessment Question)\tCurved innermost pinkie toe bone (Curved proximal toe phalanx)\tHISTOLOGY: (Biological Science Disciplines)\tGrade 2 Rash Neonatal (Finding)\tOral dysaesthesia (Psychogenic sensory disturbance of skin)", + "output": "Past Seven Days Any Stretch Marks (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as shields designed for mechanical protection and support of the nose. These trusses typically consist of a hard plastic, thermoplastic, or metallic cup-like prefabricated or custom-made device that is attached to the face using dressings and/or straps. Nose mechanical shields are mainly used to protect the external nasal bones and cartilage from injuries after trauma, illness, and/or surgery (e.g., rhinoplasty). Dedicated masks intended mainly to shield the nose are also available.\nConcepts: {SYRINGE} (Quantitative Concept)\tHealth, Womens (Population Group)\tNasal Mechanical Shields (Shields, Mechanical)\tmalyl-CoA synthetase activity (Molecular Function)\tdATP synthesis from ADP (dATP biosynthetic process)", + "output": "Nasal Mechanical Shields (Shields, Mechanical)" + }, + { + "input": "Definition: Medical Device described as reagents consisting of a substance that is established as a norm and compared with similar reagents used in immunoassay tests performed to determine agents developed by the organism that causes an immune response against its own tissue constituents (autoimmune diseases). Standard reagents may be used to determine the purity or performance of the reagents used in these tests.\nConcepts: regulation of conidium formation (regulation of asexual sporulation)\thydrops; amnii (Abnormal amniotic fluid)\tTechnic, Sociometric (Testing)\tIVD Test Reagent/Kits, Immunoassay, Standard, Autoimmune Disease (IVD Test Reagent/Kits, Immunoassay, Standard)\tlignin (Plant material)", + "output": "IVD Test Reagent/Kits, Immunoassay, Standard, Autoimmune Disease (IVD Test Reagent/Kits, Immunoassay, Standard)" + }, + { + "input": "Definition: something described as organized services for the purpose of providing diagnosis to promote and maintain health.\nConcepts: single strand break repair (Genetic Function)\tpanacea (Idea or Concept)\tService, Diagnostic (Preventive Health Services)\tAeromonas jandei (Bacterium)\tINFANTILE LIVER FAILURE SYNDROME 2 (Disease or Syndrome)", + "output": "Service, Diagnostic (Preventive Health Services)" + }, + { + "input": "Definition: Organic Chemical described as corrosive, toxic acid or its salts or esters, used as a catalyst and as a solvent.\nConcepts: Genus Alphainfluenzavirus (Virus)\tVolume Fraction (Non-SI unit of concentration)\tmesilate (Organic Chemicals)\tNeuropiles (Cell part cluster of neuraxis)\tVesicoureteral Reflux (Lower urinary tract finding)", + "output": "mesilate (Organic Chemicals)" + }, + { + "input": "Definition: short-chain fatty acid transmembrane transporter activity described as enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH.\nConcepts: propionate transmembrane transporter activity (Molecular Function)\tclinical trial exemption (Functional Concept)\tmulti-TAA-specific T cells (Allogeneic Lymphocyte)\tFiber, Postganglionic Parasympathetic (Cholinergic Fibers)\tDEVICE, AUTOMATED CELL-LOCATING (Medical Device)", + "output": "propionate transmembrane transporter activity (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as receptor Serine/Threonine Kinase Genes encode receptor proteins that each bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.\nConcepts: Intraosseous route (Musculoskeletal route)\tCDR - Personal Care (CDR Questionnaire Question)\trnax perform speech therapy service (Communication Enhancement)\tReceptor Serine/Threonine Kinase Gene (Gene or Genome)\tgrade III squamous intraepithelial neoplasia of cervix (Cervix Intraepithelial Neoplasia Grade 3 AJCC v7)", + "output": "Receptor Serine/Threonine Kinase Gene (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as roland Morris Disability Questionnaire (RDQ) Because of my back, I try not to bend or kneel down.\nConcepts: RDQ0111 (RDQ Questionnaire Question)\t10: 88506376-88674925 (Spatial Concept)\tAnesthetist's stool (Anesthesia and respiratory device)\tzirconium Zr 89-labeled atezolizumab (Amino Acid, Peptide, or Protein)\tPHOSPHOTRANSFERASES NITROGENOUS (Amino Acid, Peptide, or Protein)", + "output": "RDQ0111 (RDQ Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane.\nConcepts: Decreased circulating osteocalcin level (Abnormal circulating osteocalcin level)\tThoracic arteries (Body Part, Organ, or Organ Component)\tPhosphate product (Inorganic Chemicals)\thigh-affinity glutamate transmembrane transporter activity (Molecular Function)\tefflux permease activity (transmembrane transporter activity)", + "output": "efflux permease activity (transmembrane transporter activity)" + }, + { + "input": "Definition: Diagnostic Procedure described as a scan having a number of sequential frames.\nConcepts: Dynamic Acquisition (Radionuclide Imaging)\tTHYROPEROXIDASE (Gene or Genome)\tMaltese (Dog family)\tregulation of very-low-density lipoprotein particle remodeling (regulation of multicellular organismal process)\tday*nmol/L (Measurement Unit Description)", + "output": "Dynamic Acquisition (Radionuclide Imaging)" + }, + { + "input": "Definition: Cardiovascular monitor described as a fetal cardiac monitor is a device used to ascertain fetal heart activity during pregnancy and labor. The device is designed to separate fetal heart signals from maternal heart signals by analyzing electrocardiographic signal (electrical potentials generated during contraction and relaxation of heart muscle) obtained from the maternal abdomen with external electrodes. This generic type of device may include an alarm that signals when the heart rate crosses a preset threshold. This generic type of device includes the ``fetal cardiotachometer (with sensors)'' and the ``fetal electrocardiographic monitor.''\nConcepts: Intestinal Elimination (Drug Elimination Routes)\tFoetal cardiac monitor (electrode)\tOccupational Exposures (Environmental Exposure)\tVaginal Delivery (Birth Method of Delivery)\tTumor Purity (Cell Count)", + "output": "Foetal cardiac monitor (electrode)" + }, + { + "input": "Definition: Monoclonal Antibodies described as a recombinant immunoglobulin antibody directed against the tumor-associated antigen carcinoembryonic antigen (CEA). CEA is a cell surface glycoprotein expressed at high levels in embryonic and fetal digestive epithelial tissue, breast carcinoma, and squamous cell carcinoma of the head and neck. Except for some reactivity to skin and gastric and colon mucosa, monoclonal antibody COL-1COL-1 does not appear to react with normal tissues.\nConcepts: Breathing management each 15 minutes (Surgery and Rehabilitation)\tHAMD-21 - Obsessional and Compulsive Symptoms (Intellectual Product)\tPostnatal Drug Withdrawal (Mental or Behavioral Dysfunction)\tIntellectual disability, severe speech delay, mild dysmorphism syndrome (Global developmental delay)\tCOL-1 (Amino Acid, Peptide, or Protein)", + "output": "COL-1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of system. Comment: For example, to describe the strength of an intrauterine delivery system: \"contains 15 mg per system\".\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Hepatitis B, IgG Core Antibody (IVD Test Reagent/Kits, Serology, Virus, Hepatitis B, Core Antibody)\tVitamn D-depend ricket typ IIa (Disease or Syndrome)\tDust, Angel (Hallucinogen - non-pharmaceutical)\tSystem (Quantitative Concept)\tRPQ - Feelings of Dizziness (Intellectual Product)", + "output": "System (Quantitative Concept)" + }, + { + "input": "Definition: rhythmic process described as a process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years.\nConcepts: positive regulation of mesenchymal stem cell differentiation (Cell Function)\tGive (Instruction Imperative)\tpositive regulation of transposition, RNA-mediated (Cell Function)\tsite-specific tyrosine recombinase activity (Molecular Function)\tovulation cycle process (rhythmic process)", + "output": "ovulation cycle process (rhythmic process)" + }, + { + "input": "Definition: Physiologic Function described as any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction.\nConcepts: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction (regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction)\tDelayed Nausea and Vomiting (Nausea and vomiting)\th*ng/mL/(mg/kg/day) (Measurement Unit Description)\tMe CCNU (lomustine)\tHave Been Irritable with Other People (Intellectual Product)", + "output": "regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction (regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction)" + }, + { + "input": "Definition: Purine analog-containing product described as an arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1704\" active clinical trials using this agent.\nConcepts: Submission (Functional Concept)\tX-linked mental retardation 34 (Disease or Syndrome)\t2-Amino, 6-Methoxypurine Arabinoside (Pharmacologic Substance)\tregulation of octadecene biosynthetic process (regulation of cellular biosynthetic process)\tThyroid Gland Langerhans Cell Histiocytosis (Histiocytosis, Langerhans-Cell)", + "output": "2-Amino, 6-Methoxypurine Arabinoside (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.\nConcepts: Infantile spasms, psychomotor retardation, progressive brain atrophy, basal ganglia disease syndrome (Disease or Syndrome)\tIVD Test Reagent/Kits, Serology, Virus, Poliovirus, Antibody (IVD Test Reagent/Kits, Serology, Virus)\tUnclear Information (Finding)\tTesticular Seminoma, Tubular Variant (Neoplastic Process)\thaptoglobin binding (Molecular Function)", + "output": "haptoglobin binding (Molecular Function)" + }, + { + "input": "Definition: Individual Behavior described as personal actions to identify personal health threats\nConcepts: Laparoscopy Retrieval Pouches (Medical Device)\tribitol degradation (Molecular Function)\tRisk detection behavior (Risk control behavior)\tPictorial Work (Intellectual Product)\tCONTINUOUS (Instruction Imperative)", + "output": "Risk detection behavior (Risk control behavior)" + }, + { + "input": "Definition: something described as an antibody directed against the immunoregulatory protein B7-homologue 3 (B7-H3, CD276), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, anti-B7-H3 antibody DS-5573a binds to the cell surface antigen B7-H3, thereby blocking B7-H3-mediated signaling. This abrogates the inhibitory effect on T-cell activation and may activate the immune system to exert a cytotoxic T-lymphocyte (CTL) response against B7-H3-expressing tumor cells. B7-H3, a type I transmembrane protein and a member of the B7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells. It is a negative regulator of the T-cell activation and its overexpression plays a key role in tumor cell invasion and metastasis.\nConcepts: PACK (Activity)\tNon-lymphoblastic leukaemia acute (Neoplasms)\tAnti-B7-H3 Antibody DS-5573a (Amino Acid, Peptide, or Protein)\tLung Cancer pT1a TNM Finding v8 (Lung Cancer pT1 TNM Finding v8)\tblood chemistry study (Chemical procedure)", + "output": "Anti-B7-H3 Antibody DS-5573a (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a change in the amino acid residue at position 12 in the GTPase KRas protein where glycine has been replaced by phenylalanine.\nConcepts: KLEIHAUER-BETKE (Cytodiagnosis)\tMusculoskeletal Chest Pain due to Slipping Rib Syndrome (Sign or Symptom)\tNP 004976.2:p.Gly12Phe (Cell or Molecular Dysfunction)\tUnresolved Issue (Problem)\tER-associated glycoprotein degradation (Cell Function)", + "output": "NP 004976.2:p.Gly12Phe (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a term that refers to the pathologic staging of HPV-mediated (p16-positive) oropharyngeal carcinoma according to the American Joint Committee on Cancer, 8th edition.\nConcepts: Abnormal terminal:vellus ratio (Finding)\tADAS-Cog CDISC Version Questionnaire Question (Intellectual Product)\tHPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 pTNM Stage (HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage)\tdown-regulation of nodal signaling (regulation of nodal signaling pathway)\tIncreased level of anti-animal protein IgE antibody (Finding)", + "output": "HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 pTNM Stage (HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma by AJCC v8 Stage)" + }, + { + "input": "Definition: Method Code described as a coded value specifying the respiratory motion technique.\nConcepts: Reticulolymphosarcoma (leukemia)\tRespiratory Motion Technique Code (Intellectual Product)\tmurine leukemia virus (Leukoviruses - Subgenus B)\t4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4C)rifamycin (Anti-Bacterial Agents)\tRhizoctonia, NOS (Corticiaceae)", + "output": "Respiratory Motion Technique Code (Intellectual Product)" + }, + { + "input": "Definition: Flavonoids described as a group of FLAVONOIDS derived from FLAVONOLS, which lack the ketone oxygen at the 4-position. They are glycosylated versions of cyanidin, pelargonidin or delphinidin. The conjugated bonds result in blue, red, and purple colors in flowers of plants.\nConcepts: Anthocyanins (Glycosides)\tPremature epimetaphyseal fusion in foot (Premature epiphyseal closure)\tToilet-Back Supports (Medical Device)\targinyl-tRNA-protein transferase activity (Molecular Function)\tFluorides, Tin (Inorganic Chemical)", + "output": "Anthocyanins (Glycosides)" + }, + { + "input": "Definition: Manufactured form described as a questionnaire or measure that is administered on an electronic device, such as a computer, tablet, or smartphone.\nConcepts: Clinical Trials Support Unit (Professional Organization or Group)\t4-nitropyrene (Nitroarene Carcinogen)\tArabic numeral 23 (Numbers)\tHSP105A (HSPH1 gene)\tElectronic Form (Intellectual Product)", + "output": "Electronic Form (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as STILBENES with AMIDINES attached.\nConcepts: clinical anxiety (Mental or Behavioral Dysfunction)\tisopropylmalate transport (organic hydroxy compound transport)\tStilbamidines (Organic Chemical)\tAppendicular Skeleton, Trunk, Skull, and Facial Bones Cancer pT1 TNM Finding v8 (Finding)\tRenal tubular epithelial cell casts (Finding)", + "output": "Stilbamidines (Organic Chemical)" + }, + { + "input": "Definition: something described as a family of genes that encode major histocompatibility complex proteins and are involved in the presentation of cytoplasmic protein fragments to cytotoxic lymphocytes.\nConcepts: Reagents, Clinical Chemistry, Rapid Test, pH, Strip (Medical Device)\tregulation of endogenous peptide antigen processing and presentation via MHC class I (Cell Function)\tClass I Gene (Major Histocompatibility Complex)\tT-Cell Prolymphocytic Leukemia, S\u00e9zary Cell-like Variant (Neoplastic Process)\tShort middle bone of index finger (Short middle phalanx of finger)", + "output": "Class I Gene (Major Histocompatibility Complex)" + }, + { + "input": "Definition: Toxin described as substances, usually of biological origin, that destroy blood cells; may be antibodies or other immunologic factors, toxins, enzymes, etc.; hemotoxins are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.\nConcepts: Hemotoxins (Hazardous or Poisonous Substance)\tSTK30 (Molecular Function)\tMedical Care I Have Been Receiving is Just About Perfect (Intellectual Product)\tAdvanced Thyroid Gland Medullary Carcinoma (Metastatic Thyroid Gland Medullary Carcinoma)\tGrade 2 Anal mucositis (Anal Mucositis, CTCAE)", + "output": "Hemotoxins (Hazardous or Poisonous Substance)" + }, + { + "input": "Definition: Myosarcoma described as a malignant neoplasm, originating from smooth muscle cells.\nConcepts: positive regulation of beta 2 integrin biosynthetic process (regulation of beta 2 integrin biosynthetic process)\tleiomyosarcomas (Leiomyosarcoma - category)\tCardiac sclerosis (Atherosclerosis)\tspecification of posterior mesonephric tubule identity (specification of mesonephric tubule identity)\tInducible Myocardial Ischemia (Cardiovascular finding)", + "output": "leiomyosarcomas (Leiomyosarcoma - category)" + }, + { + "input": "Definition: Soft tissue lesion described as a vascular disease of the LIVER characterized by the occurrence of multiple blood-filled CYSTS or cavities. The cysts are lined with ENDOTHELIAL CELLS; the cavities lined with hepatic parenchymal cells (HEPATOCYTES). Peliosis hepatis has been associated with use of anabolic steroids (ANABOLIC AGENTS) and certain drugs.\nConcepts: Teacher (Occupational Groups)\thepatis; peliosis (Vascular Diseases)\tPODCI104 (Intellectual Product)\tstage IIA soft tissue sarcoma (Stage II Soft Tissue Sarcoma AJCC v7)\tAplasia of the musculature of the pelvis (Congenital Abnormality)", + "output": "hepatis; peliosis (Vascular Diseases)" + }, + { + "input": "Definition: Medical Device described as a metal scaffold placed via a delivery catheter into the superficial femoral artery artery to maintain the lumen\nConcepts: STENT, SUPERFICIAL FEMORAL ARTERY (Medical Device)\tOrthosis, Foot (Orthosis for lower limb)\tSpinal Surgery Punches (Surgical punch)\tUnsaturated iron binding capacity (Blood hematinic measurement)\tbookings (Publications)", + "output": "STENT, SUPERFICIAL FEMORAL ARTERY (Medical Device)" + }, + { + "input": "Definition: Drug allergens described as sulfhydryl acylated derivative of GLYCINE.\nConcepts: Product containing nicardipine (Dihydropyridine Calcium Channel Blocker [EPC])\tLikert Score 5 (Clinical or Research Assessment Answer)\tPAPS transporter activity (adenine nucleotide transmembrane transporter activity)\t2 Mercaptopropionylglycine (Agent Affecting Blood or Body Fluid)\tfdng asesmnt (Therapeutic or Preventive Procedure)", + "output": "2 Mercaptopropionylglycine (Agent Affecting Blood or Body Fluid)" + }, + { + "input": "Definition: Finding described as a finding about one or more characteristics of appendiceal carcinoma, following the rules of the TNM AJCC v7 classification system.\nConcepts: Referral Made Based on Final Score (Intellectual Product)\tAppendiceal Carcinoma TNM Finding v7 (Finding)\tROOM TEMPERATURE (Qualitative Concept)\tpT3 Uterine Carcinoma TNM Finding v6 (Finding)\tdichotomous subdivision of an epithelial terminal unit (morphogenesis of an epithelium)", + "output": "Appendiceal Carcinoma TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as devices used to deliver oxygen or a mixture of oxygen and air to patients via their tracheostomy airway. The masks are typically connected to an oxygen source with tubing and are constructed of plastic. Tracheostomy masks can be used over a tracheostomy tube or stoma, and are typically fastened around the patient's neck via a disposable strap or ties. These devices are frequently referred to as \"trach collars\" or \"tracheostomy collars.\"\nConcepts: regulation of interferon-gamma synthesis (regulation of interferon-gamma production)\tcargo loading into clathrin-coated vesicle, AP-3-mediated (Molecular Function)\thomeobox A1 protein, human (TRANSCRIPTION FACTOR)\tNucleus accumbens septi (Neostriatum)\tTracheostomy Masks (Oxygen mask)", + "output": "Tracheostomy Masks (Oxygen mask)" + }, + { + "input": "Definition: Injury or Poisoning described as the formation of scar tissue as a result of radiation therapy.\nConcepts: radiation fibrosis (Radiation injury)\tFactor XIII Deficiencies (Hematology)\tprotein transport (Cell Function)\t6-sulfoquinovose(1-) metabolism (Sulfur Metabolism Pathway)\tMycosis Fungoides and S\u00e9zary Syndrome N0 TNM Finding v7 (Finding)", + "output": "radiation fibrosis (Radiation injury)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-carboxy-2-hydroxy-8-carboxychromene = 2-hydroxy-3-carboxybenzalpyruvate.\nConcepts: glycerin-3-phosphate dehydrogenase activity (Molecular Function)\t2-carboxy-2-hydroxy-8-carboxychromene isomerase activity (intramolecular oxidoreductase activity)\tUnilateral Anatomic Qualifier (Anatomy Qualifier)\tPlan/Organize Scale (Intellectual Product)\tGrade 2 Colonic ulcer (Finding)", + "output": "2-carboxy-2-hydroxy-8-carboxychromene isomerase activity (intramolecular oxidoreductase activity)" + }, + { + "input": "Definition: Diagnostic Factor described as a measure of the increase in the level of blood glucose (a type of sugar) caused by eating a specific carbohydrate (food that contains sugar) compared with eating a standard amount of glucose. Foods with a high glycemic index release glucose quickly and cause a rapid rise in blood glucose. Foods with a low glycemic index release glucose slowly into the blood. A relationship between the glycemic index and recurrent colorectal cancer is being studied.\nConcepts: Container Dosing Unit (Quantitative Concept)\tGI (Nutritive Value)\tUHDRS 1999 Version - Suicidal Thoughts: Frequency (UHDRS 1999 Version Clinical Classification Question)\tsuccinate-CoA ligase activity (Molecular Function)\tIQ MOTIF-CONTAINING GTPase-ACTIVATING PROTEIN 2 (Gene or Genome)", + "output": "GI (Nutritive Value)" + }, + { + "input": "Definition: SIQ-JR Questionnaire Question described as suicidal Ideation Questionnaire-JR - I thought about how I would kill myself.\nConcepts: AQ0113 (AQ20 Questionnaire Question)\tDecreased number of sternal ossification centers (Abnormal sternal ossification)\tSIQ0203 (SIQ-JR Questionnaire Question)\tNut Oil (Food Oil)\tP2Y12 defect (Disease or Syndrome)", + "output": "SIQ0203 (SIQ-JR Questionnaire Question)" + }, + { + "input": "Definition: Steroids described as c27 hydrocarbon parent structure for the synthesis of mammalian steroids.\nConcepts: Secondary Acalculia (Mental or Behavioral Dysfunction)\tCholestanes (Steroids)\tComplex and Mixed Neoplasms (Neoplasms by Histologic Type)\tResuscitators, Pulmonary, Manual, Reusable (biomedical tube device)\tpT3b Bladder Carcinoma TNM Finding (Bladder Cancer pT3 TNM Finding v6 and v7)", + "output": "Cholestanes (Steroids)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell differentiation involved in phenotypic switching.\nConcepts: up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching (regulation of vascular smooth muscle cell differentiation involved in phenotypic switching)\talpha1-beta1 integrin complex location (Cell Component)\tErythroid Cells/Nucleated Cells (Blood Cell Count Ratio Measurement)\tTransformed Non-Hodgkin Lymphoma (Lymphoma, Non-Hodgkin)\tCell cavity (Anatomical space structure)", + "output": "up-regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching (regulation of vascular smooth muscle cell differentiation involved in phenotypic switching)" + }, + { + "input": "Definition: Device Labeled for Single Use described as products that combine solid paraffin with dry mud that have medical (e.g., analgesic) properties obtained from natural sources. The product is usually heated until it melts and is applied in thick layers on areas of skin just when it becomes solid again, at a temperature in the range between 38 to 45 degrees Celsius (100 to 113 degrees Fahrenheit). The product is typically applied for a time period of less than one hour. Combined products of natural mud with paraffin are intended to help in relieving chronic pain and stiffness and also to alleviate muscle spasms.\nConcepts: Dry Mud/Paraffin, Physical Therapy (Medical Device)\tHyperinsulinism due to INSR (insulin receptor) deficiency (Autosomal dominant hereditary disorder)\t188Re-BMEDA-liposomes (Radioconjugate)\tPlatelets (Pharmacologic Substance)\tregulation of tyrosine phosphorylation of STAT protein (Cell Function)", + "output": "Dry Mud/Paraffin, Physical Therapy (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as the method in which data was obtained about a device.\nConcepts: Bordetella petrii (genus Bordetella)\tUnique Device Identifier Entry Method (Methods)\tVERTEBRA ABNORMAL (Vertebral column)\tNutrition, Water (Research Activity)\tWestern Ragweed Pollen IgE AB RAST Score (Laboratory Procedure)", + "output": "Unique Device Identifier Entry Method (Methods)" + }, + { + "input": "Definition: Cell Cycle Control described as any process that modulates the frequency, rate or extent of DNA endoreduplication.\nConcepts: gene-modified (Property or Attribute)\tXp22.13p22.2 duplication syndrome (Chromosomal Duplication)\tregulation of DNA re-duplication (regulation of DNA-dependent DNA replication)\tTissue Perfusion Management (Physiological: Complex)\tBiologic Entity Part Anatomic Site Laterality Code (Anatomic Site Laterality Code)", + "output": "regulation of DNA re-duplication (regulation of DNA-dependent DNA replication)" + }, + { + "input": "Definition: regulation of transcription by pheromones described as any process involving pheromones that modulates the frequency, rate or extent or transcription from an RNA polymerase II promoter.\nConcepts: Trioxopurine (Organic Chemicals)\tregulation of potassium ion transmembrane transporter activity (regulation of potassium ion transmembrane transport)\tregulation of transcription from RNA polymerase II promoter by pheromones (Genetic Function)\tHidradenitis (Other specified disorders of sweat glands)\tNerve agent GB (Nerve Agents)", + "output": "regulation of transcription from RNA polymerase II promoter by pheromones (Genetic Function)" + }, + { + "input": "Definition: Clinical or Research Facility described as a facility responsible for various analyses on tissue samples.\nConcepts: Retention, Denture (Dentures)\tLaboratory or Pathology Department (Health Care Related Organization)\tmorula (Pre-embryonic structure)\tnegative regulation of phosphatidylinositol biosynthetic process (regulation of phosphatidylinositol biosynthetic process)\tKingdom (Linnaean taxonomic ranks)", + "output": "Laboratory or Pathology Department (Health Care Related Organization)" + }, + { + "input": "Definition: Observed Volume of Distribution of Absorbed Fraction described as the volume of distribution associated with the terminal slope following extravascular administration divided by the fraction of dose absorbed, calculated using the observed value of the last non-zero concentration and corrected for unbound drug.\nConcepts: Observed Volume of Distribution of Absorbed Fraction for Unbound Drug (Quantitative Concept)\ttotal fissure (Body Space or Junction)\tIPAQ Short Last 7 Days Telephone Format Version - Total Vigorous Hours per Week (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tE3 Ubiquitin-Transferase Gene (Transferase Gene)\tAbnormal left atrium morphology (Anatomical Abnormality)", + "output": "Observed Volume of Distribution of Absorbed Fraction for Unbound Drug (Quantitative Concept)" + }, + { + "input": "Definition: Hereditary Diseases described as a rare genetic lissencephaly with cerebellar hypoplasia subtype with characteristics of classical lissencephaly with thickened cortical grey matter (with either no discernable gradient, a predominantly posterior gradient, or a predominantly anterior gradient) associated with variable predominantly midline cerebellar hypoplasia.\nConcepts: D-Alanine Aminotransferase (Enzyme)\tTIPS AND PADS, CANE, CRUTCH AND WALKER (Medical Device)\tMicrococcus cinereus (Bacterium)\tLissencephaly co-occurrent with congenital cerebellar hypoplasia type A (Lissencephaly with cerebellar hypoplasia)\tGrade 2 Vulval Infection, CTCAE (Vulval Infection, CTCAE)", + "output": "Lissencephaly co-occurrent with congenital cerebellar hypoplasia type A (Lissencephaly with cerebellar hypoplasia)" + }, + { + "input": "Definition: pathologic cytolysis described as osteolysis refers to the destruction of bone through bone resorption with removal or loss of calcium.\nConcepts: DENT ARTICULATORS (Dental Equipment and Supplies)\tosteolysis (Osteolysis)\tVena ileocolica (Structure of colic vein)\tFree and Sovereign State of Sonora (Geographic Area)\tCD34 Monoclonal Antibody (Monoclonal Antibodies)", + "output": "osteolysis (Osteolysis)" + }, + { + "input": "Definition: Viral labyrinthitis described as idiopathic inflammation of the VESTIBULAR NERVE, characterized clinically by the acute or subacute onset of VERTIGO; NAUSEA; and imbalance. The COCHLEAR NERVE is typically spared and HEARING LOSS and TINNITUS do not usually occur. Symptoms usually resolve over a period of days to weeks.\nConcepts: Celibacy, NOS (Personal status)\tEpidemic Neurolabyrinthitis (Vestibular Neuronitis)\tnegative regulation of cell growth involved in cardiac muscle cell development (regulation of cell growth involved in cardiac muscle cell development)\tvanadium ion binding (Molecular Function)\tUDP-glucose:kinetin 7-N-glucosyltransferase activity (hexosyltransferase activity)", + "output": "Epidemic Neurolabyrinthitis (Vestibular Neuronitis)" + }, + { + "input": "Definition: Device Evaluation Result described as problems with a device that can be traced to a problem in the manufacturing and/or production process.\nConcepts: ENTEROCOCCUS MUNDTII (Enterococcus, group II)\tstress reduction techniques (Therapeutic or Preventive Procedure)\tManufacturing Process Problem Identified (Finding)\tMSC 2490484A (Organic Chemical)\tIncreased circulating creatine kinase BB isoform (Finding)", + "output": "Manufacturing Process Problem Identified (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as ammonium ichthyol sulphonate.\nConcepts: Kruskal-Wallis Test (Non-Parametric Test)\tichthyolum/ammonium ichthyol (Organic Chemical)\tADAPTOMETER (Ophthalmological equipment)\tDNA Unwinding Protein (Enzyme)\tdimethylallyl-diphosphate:ADP dimethylallyltransferase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)", + "output": "ichthyolum/ammonium ichthyol (Organic Chemical)" + }, + { + "input": "Definition: Structure of deep anterior cervical lymph node described as a lymph node located adjacent to the trachea within the mediastinum.\nConcepts: paratracheal lymph node (Lymph Node by Anatomic Site)\thistone H3-R26 citrullination (Molecular Function)\tUnresectable Round Cell Liposarcoma (Round Cell Liposarcoma)\tManitoba (Prairie Provinces of Canada)\tnegative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis (negative regulation of cardiac ventricle development)", + "output": "paratracheal lymph node (Lymph Node by Anatomic Site)" + }, + { + "input": "Definition: Acanthamoeba described as any amoebic organism that can be assigned to the species Acanthamoeba rhysodes.\nConcepts: Catenin (Cadherin-Associated Protein), Beta 1 (88kD) Gene (CTNNB1 gene)\tNRNT (Functional Concept)\tparaxial mesodermal cell fate specification (Organ or Tissue Function)\tACANTHAMOEBA RHYSODES (Acanthamoeba)\tC-SSRS Baseline - Duration of Most Severe Ideation (C-SSRS Baseline Questionnaire Question)", + "output": "ACANTHAMOEBA RHYSODES (Acanthamoeba)" + }, + { + "input": "Definition: something described as degenerative changes of the peripheral retina consisting of close-packed tiny cystic spaces at the outer plexiform/inner nuclear retinal level. The degeneration is very common in adult eyes and starts adjacent to the ora serrata and extends circumferentially and posteriorly.\nConcepts: camellia (Theaceae)\tA05 ANDROGENIC PREPARATIONS (Types of drugs A-G)\tsignal peptidase complex (Cell Component)\tPeripheral cystoid retinal degeneration (Peripheral retinal degeneration)\tdisorders platelets (Platelet disorders NEC)", + "output": "Peripheral cystoid retinal degeneration (Peripheral retinal degeneration)" + }, + { + "input": "Definition: something described as to cut a very thin slice of tissue or other substance.\nConcepts: SGRQ02-Embarrassed Using Med in Public (Intellectual Product)\tProject Type (Qualitative Concept)\tlactone biosynthesis (Molecular Function)\tAlanine Nitrogen Mustard (M [Preparations])\tSectioning (Tissue processing technique)", + "output": "Sectioning (Tissue processing technique)" + }, + { + "input": "Definition: vesicle organization described as a protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination.\nConcepts: Long-Term Potentiation (positive regulation of synaptic transmission)\tnerve ending (craniospinal nerves)\tvesicle coating (Cell Function)\tActinobacillus lignieresii Brumpt 1910 (Bacterium)\tupregulation of somatic stem cell population maintenance (positive regulation of stem cell population maintenance)", + "output": "vesicle coating (Cell Function)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable inhibitor of protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; Src homology region 2 domain phosphatase; PTPN11), with potential antineoplastic activity. Upon oral administration, SHP2 inhibitor JAB-3068 targets, binds to and inhibits the activity of SHP2. This prevents SHP2-mediated signaling, inhibits MAPK signaling and prevents growth of SHP2-expressing tumor cells. SHP2, an oncoprotein overexpressed in a variety of cancer cell types, regulates cell survival, differentiation and proliferation through activation of the Ras-Raf-MEK-ERK signaling pathway. The Ras-MAPK pathway is often hyperactivated in cancer cells due to specific mutations and rearrangements and are dependent on SHP2 for their oncogenic signaling. SHP2 also regulates programmed cell death 1 (PD-1)-mediated signal transduction and is involved in immune checkpoint modulation.\nConcepts: Abnormal eating behaviour (Abnormal consumption behavior)\tHistone Modification (Post-Translational Protein Processing)\tOvarian, Fallopian Tube, and Primary Peritoneal Carcinoma FIGO Stage IIIA1ii (Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma pN1 TNM Finding v8)\tCarcinogenic Aromatic Amine (Classification)\tJAB 3068 (Pharmacologic Substance)", + "output": "JAB 3068 (Pharmacologic Substance)" + }, + { + "input": "Definition: Finding described as melanoma of the iris with extrascleral extension.\nConcepts: Inflammatory Polyneuropathy Acute (Disease or Syndrome)\tPontine reticulospinal tract (Tract of spinal cord)\tMelanoma of the Iris pT4 TNM Finding v7 (Finding)\tMelanoma of the Iris pT3a TNM Finding v7 (Melanoma of the Iris pT3 TNM Finding v7)\tregulation of cellular respiration (Cell Function)", + "output": "Melanoma of the Iris pT4 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Cell Function described as the directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: cellular component organisation or biogenesis at cellular level (cellular process)\tparaventricular hypothalamic nucleus, parvicellular division, anterior parvicellular part (parvicellular division of the paraventricular nucleus)\tGenus Ectothiorhodospira (Bacterium)\tpolyamine transport (organic substance transport)\tStage II Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8 (Neoplastic Process)", + "output": "polyamine transport (organic substance transport)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.\nConcepts: levator ani syndrome (Abdominal Pain)\tCSS01-Non-Specific Suicidal Thought (C-SSRS Baseline Questionnaire Question)\tEpithelial Predominant Renal Wilms' Tumor (Neoplastic Process)\trifamycin B oxidase activity (Molecular Function)\tLDL receptor catabolic process (Molecular Function)", + "output": "LDL receptor catabolic process (Molecular Function)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells. When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues. This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils.\nConcepts: Lym-1 (Antineoplastic Antibody)\tGrade 3 Vomiting, CTCAE (Finding)\tTelephonic Format with Interactive Voice Response Technology (Telephonic Format)\tCHEM PHYSICAL (Occupation or Discipline)\tmedical model (Disease theory of Alcohol or Other Drug Use, Abuse and Dependence)", + "output": "Lym-1 (Antineoplastic Antibody)" + }, + { + "input": "Definition: something described as this gene is involved in both transcriptional regulation and mesoderm development.\nConcepts: TFT (Transcription factor genes)\tTenderness (Pain Disorder)\tobsolete anaphylaxis (Acute allergic reaction)\tAbnormality of risorius muscle (Anatomical Abnormality)\tregulation of basidium development (Biologic Function)", + "output": "TFT (Transcription factor genes)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Young Children - Please indicate how often the child has done, felt, or experienced each of the following things in the last month: Becoming very angry over a little thing.\nConcepts: Soapberry (Order Sapindales)\tTSCYC1-Very Angry Over a Little Thing (Intellectual Product)\t11: 65869132-65861387 (Chromosome 11 Physical Location)\toestrogen secretion (Organ or Tissue Function)\tneuroblastoma, hereditary (Hereditary Malignant Neoplasm)", + "output": "TSCYC1-Very Angry Over a Little Thing (Intellectual Product)" + }, + { + "input": "Definition: something described as an order of extremely thermophilic, sulfate-reducing archaea, in the kingdom EURYARCHAEOTA. The single family Archaeoglobaceae contains one genus ARCHAEOGLOBUS.\nConcepts: Tearing pain (Sign or Symptom)\tData Management Systems, Clinical Pharmacy, Electronic Medication Administration Record (Intellectual Product)\tFACT-B Version 4 - One or Both Arms Are Swollen or Tender (Intellectual Product)\thydroxyphytanate oxidase activity (Molecular Function)\tOrder Archaeoglobales (Euryarchaeota)", + "output": "Order Archaeoglobales (Euryarchaeota)" + }, + { + "input": "Definition: Intellectual Product described as a question about how bothered an individual is by swelling in their affected underarm, arm, or hand.\nConcepts: How Much Bothered by Swelling in Affected Underarm, Arm, or Hand (Clinical or Research Assessment Question)\tacro osteolysis (Bone Diseases)\tSF-36 v2.0 Acute - Question 3c (Intellectual Product)\tmTOR Protein Variant (Cell or Molecular Dysfunction)\tTERF1 (TRF1)-interacting nuclear factor 2 protein, human (DNA repair protein)", + "output": "How Much Bothered by Swelling in Affected Underarm, Arm, or Hand (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Paraganglioma AND/OR glomus tumor described as a malignant neoplasm arising from paraganglia located along nerves composed of neoplastic neuroectodermal chromaffin cells.\nConcepts: Paraganglion Neoplasm, Malignant (Paraganglioma AND/OR glomus tumor)\tGlucose measurement, plasma (Plasma Chemistry Test)\t\u00e1cido b\u00f3rico (Borates)\tmHealth (Health Care Activity)\tguanosine 5'-monophosphate reductase activity (oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor)", + "output": "Paraganglion Neoplasm, Malignant (Paraganglioma AND/OR glomus tumor)" + }, + { + "input": "Definition: Cell Function described as any intracellular signal transduction that is involved in meiotic spindle checkpoint.\nConcepts: actinorhodin breakdown (quinone catabolic process)\tCOMPLEMENT C 03 C 05 CONVERTASES (Enzyme)\tnuclear meiotic cohesin complex location (nuclear cohesin complex)\tintracellular signal transduction involved in meiotic spindle checkpoint (signal transduction involved in spindle checkpoint)\tNumber of Renal Arteries (Quantitative Concept)", + "output": "intracellular signal transduction involved in meiotic spindle checkpoint (signal transduction involved in spindle checkpoint)" + }, + { + "input": "Definition: Gene or Genome described as this gene may enhance ubiquitin ligase activity.\nConcepts: Melanoma Antigen Family C, 2 Gene (Gene or Genome)\tNon-specified HCPCS II respiratory or oxygen device, equipment or supply reference code no charge (Tracking code use with or without ICD diagnosis)\t1H-1,2,4-Triazole-3-carboxamide, 1-beta-D-ribofuranosyl- (Drug allergens)\tExpert Testimony (Occupational Activity)\tex vivo anti-CD3/CD28 costimulated, rapamycin-polarized Th1/Tc1 autologous T lymphocytes (therapeutic autologous lymphocytes)", + "output": "Melanoma Antigen Family C, 2 Gene (Gene or Genome)" + }, + { + "input": "Definition: negative regulation of axon guidance described as any process that stops, prevents or reduces the frequency, rate or extent of motor neuron axon guidance.\nConcepts: Juniperus sabina / savine (Pharmacologic Substance)\tFixed Block (Body Substance)\tActivin A Receptor, Type II wt Allele (ACVR2A gene)\tdown-regulation of motor axon guidance (regulation of motor neuron axon guidance)\tRECEIVING (Qualitative Concept)", + "output": "down-regulation of motor axon guidance (regulation of motor neuron axon guidance)" + }, + { + "input": "Definition: Experimental Organism Neoplasm described as a benign neoplasm arising from the yolk sac.\nConcepts: bacteriocin breakdown (peptide antibiotic catabolic process)\tpositive regulation of conidiophore stalk development (regulation of conidiophore stalk development)\tGadoxetate Disodium (Gadolinium-Chelate)\tgomphosis (Set of all joints of head)\tYOLK SAC TUMOR, BENIGN (Neoplastic Process)", + "output": "YOLK SAC TUMOR, BENIGN (Neoplastic Process)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions in the galactosylceramidase (GALC) gene, located in 14q31, which encodes for the enzyme galactosylceramidase that hydrolyzes several galactolipids, important in the production of myelin, kidney, and epithelial cells of the colon and small intestine. Inherited genetic deletions are present in patients with early (infant) onset of Krabbe's disease.\nConcepts: 1,6-beta-glucan biosynthetic process (beta-glucan biosynthetic process)\twaste water (Waste Products)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion, GALC (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion)\tUHDRS 1999 Version - Finances (Intellectual Product)\taerobactin transport (Cell Function)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion, GALC (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion)" + }, + { + "input": "Definition: Medical Device described as a tympanostomy tube is a device that is intended to be implanted for ventilation or drainage of the middle ear. The device is inserted through the tympanic membrane to permit a free exchange of air between the outer ear and middle ear. A type of tympanostomy tube known as the malleous clip tube attaches to the malleous to provide middle ear ventilation. The device is made of materials such as polytetrafluoroethylene, polyethylene, silicon elastomer, or porous polyethylene.\nConcepts: Rare isolated myopia (Hereditary disorder of the visual system)\ttympanostomy tubes (biomedical tube device)\tCAF1 (Gene or Genome)\tCongenital trismus (Temporomandibular ankylosis)\tImmature Peripheral Gamma/Delta Cell of Cytotoxic Type (Cell)", + "output": "tympanostomy tubes (biomedical tube device)" + }, + { + "input": "Definition: something described as deployment Risk & Resilience Inventory-2 - Before deployment: I experienced a natural disaster (for example, a hurricane), a fire, or an accident in which I or someone close to me was hurt or had serious property damage.\nConcepts: MVF-HER-2(597-626)-MVF-HER-2 (266-296) peptide vaccine (Pharmacologic Substance)\tAbsent middle phalanx of the 3rd toe (Aplasia of the phalanges of the 3rd toe)\tDRRI1A08 (Intellectual Product)\tVeins, Pulmonary (Veins)\tmodulation by organism of host SA-mediated defense response (Organism Function)", + "output": "DRRI1A08 (Intellectual Product)" + }, + { + "input": "Definition: Vulvar adenocarcinoma described as an eccrine adenocarcinoma that arises from the sweat glands in the vulva.\nConcepts: ltr H undef.Orntl hrb&ntrl s (Plant)\tSulphametopyrazine (Sulfonamide Anti-Infective Agents)\tcyanidin 3-O-glucoside-(2''-O-xyloside) 6''-O-acyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tFlerobuterol (Adrenergic beta-Agonists)\tVulvar Eccrine Adenocarcinoma (Eccrine carcinoma of skin)", + "output": "Vulvar Eccrine Adenocarcinoma (Eccrine carcinoma of skin)" + }, + { + "input": "Definition: Antiarrhythmic [EPC] described as an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.\nConcepts: OXOSTEROID ISOMERASES 03 (Amino Acid, Peptide, or Protein)\tSotalol product (Anti-Arrhythmia Agents)\tPICK, MASSAGING (Medical Device)\thexuronate (Biologically Active Substance)\tTriggered by sudden movement (Triggered by)", + "output": "Sotalol product (Anti-Arrhythmia Agents)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the inner layer of the dura mater surrounding the brain. It is mostly fused with the outer layer, the endocranium that is adherent to the inner aspect of the cranial bones. These two layers form the dura mater. The latter covers and protects the brain and the spinal cord.\nConcepts: Meningeal dura (Meninges)\tStudy Registry Identifier (Intellectual Product)\tPaced Tapping - Deviation Interval Tone Trial (Paced Tapping Functional Test Question)\tStage II Ureter Cancer (Ureter Cancer by AJCC v8 Stage)\tMalignant Medulloepithelioma of Ciliary Body (Intraocular Medulloepithelioma)", + "output": "Meningeal dura (Meninges)" + }, + { + "input": "Definition: something described as stent Thrombosis Coronary ARC Grade (ARC STC Grade) A grading system to describe the coronary stent thrombosis per the classification schema described by the Academic Research Consortium.\nConcepts: vocalisation behaviour (Individual Behavior)\tSTCG01-STC ARC Grade (ARC STC Grade Clinical Classification Question)\tNSAID Total Dose (Dosage)\tup regulation of mammary gland epithelial cell proliferation (positive regulation of epithelial cell proliferation)\tFamily Rhodospirillaceae (Bacterium)", + "output": "STCG01-STC ARC Grade (ARC STC Grade Clinical Classification Question)" + }, + { + "input": "Definition: Finding described as lack of formation of mineralized bony tissue of the sternum.\nConcepts: SEC22 HOMOLOG B, VESICLE TRAFFICKING PROTEIN (Trafficking Protein Gene)\tDevelopmental groove of tooth (Zone of crown of tooth)\tGBD domain binding (protein domain specific binding)\tAbsent sternal ossification (Finding)\tTopoisomerase, DNA, III, Alpha (Topoisomerase III)", + "output": "Absent sternal ossification (Finding)" + }, + { + "input": "Definition: Gastrointestinal perforation described as a rupture in the duodenal wall due to traumatic or pathologic processes.\nConcepts: 50 Percent Embryo Infective Dose per Dose (Unit of Arbitrary Substance Concentration)\tallogeneic multipotent adult progenitor cells (Cell)\tNational Nanotechnology Initiative Project Component Area 3 (Research Activity)\tPerforation of duodenum (Disease or Syndrome)\tNerve rootlet complex of spinal nerve (Body Part, Organ, or Organ Component)", + "output": "Perforation of duodenum (Disease or Syndrome)" + }, + { + "input": "Definition: something described as neuropsychiatric Inventory (NPI) Does the patient describe feeling things on his/her skin or otherwise appear to be feeling things crawling or touching him/her?\nConcepts: ADCS-ADL - Left Away From Home for Fifteen Minutes or Longer (ADCS-ADL Questionnaire Question)\tTISSUE FACTOR (Gene or Genome)\tcbc differentials (Laboratory Procedure)\tNPI - Describe Feeling Things on His/Her Skin (NPI Questionnaire Question)\tProsthesis Failure (Phenomenon or Process)", + "output": "NPI - Describe Feeling Things on His/Her Skin (NPI Questionnaire Question)" + }, + { + "input": "Definition: something described as an invasive therapeutic procedure to destroy tissue in an accessory pathways in the atrioventricular conduction system that contributes to arrhythmia.\nConcepts: Software Version (Intellectual Product)\tBOLD Venographic Imaging (Magnetic Resonance Imaging)\t45B (Body Location or Region)\ttranslation initiation factor binding (Molecular Function)\tAblation of Cardiac Accessory Pathway (Cardiac ablation)", + "output": "Ablation of Cardiac Accessory Pathway (Cardiac ablation)" + }, + { + "input": "Definition: Neuroendocrine Tumors described as an insulin-producing neuroendocrine tumor arising from the beta cells of the pancreas. Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin.\nConcepts: PSA Level Greater than or Equal to 10 (PSA Level Finding)\tHow often have you had crampy pain in your abdomen, pelvis or rectum (Intellectual Product)\tmemory T cell proliferation (T-Cell Proliferation)\tinsulinoma; unspecified site (Gastrointestinal hormone-secreting endocrine tumor)\tPick; disease or syndrome (Degenerative Diseases, Central Nervous System)", + "output": "insulinoma; unspecified site (Gastrointestinal hormone-secreting endocrine tumor)" + }, + { + "input": "Definition: Radiation Detectors described as an instrument that can determine the amount of ionizing radiation in a sample.\nConcepts: dorsal part of the agranular insular area (agranular insular cortex)\tMIR197 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tDecreased male libido (Male sexual dysfunction)\tTablet, effervescent (Biomedical or Dental Material)\tscintillation counter (Radiology/Radiation Therapy Equipment and Supplies)", + "output": "scintillation counter (Radiology/Radiation Therapy Equipment and Supplies)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant epithelial tumor with a glandular organization that originates in the ileum.\nConcepts: Ileal adenocarcinoma (Adenocarcinoma of small intestine)\tLate or Variable Onset (Temporal Concept)\tConjunctival melanoma (Neoplasm by body site)\tHSTF1 (Gene or Genome)\tEMO107A (ERT Functional Test Question)", + "output": "Ileal adenocarcinoma (Adenocarcinoma of small intestine)" + }, + { + "input": "Definition: PADI4 gene described as human PADI4 wild-type allele is located in the vicinity of 1p36.13 and is approximately 56 kb in length. This allele, which encodes protein-arginine deiminase type-4 protein, plays a role in the post-translational protein modification. Mutation of the gene is associated with susceptibility to rheumatoid arthritis.\nConcepts: aminopterin fetopathy syndrome (Multiple malformation syndrome due to environmental agent)\tAdvanced Papillary Renal Cell Carcinoma (Neoplastic Process)\tasclepias tuberosa/pleurisy (Pharmacologic Substance)\tPrograms, Computer (Computer equipment)\tPAD (Gene or Genome)", + "output": "PAD (Gene or Genome)" + }, + { + "input": "Definition: Organic Chemical described as an anhydrous sodium salt formulation of phosphonoacetic acid with activity against herpes simplex viruses and other members of the herpes virus family. Fosfonet inhibits viral DNA polymerase and inhibits the synthesis of viral DNA.\nConcepts: Refrain from Smoking when Celebrating Something (Intellectual Product)\tA type intraocular melanoma, spindle cell (Spindle cell melanoma, type A)\tFOSFONET SODIUM ANHYDROUS (DNA Polymerase Inhibitors)\tcalcium ion regulated lysosome exocytosis (calcium-ion regulated exocytosis)\tparamedian pontine reticular formation (Body Part, Organ, or Organ Component)", + "output": "FOSFONET SODIUM ANHYDROUS (DNA Polymerase Inhibitors)" + }, + { + "input": "Definition: Mcl-1 Inhibitor described as an inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.\nConcepts: Rolandic Epilepsy (Epileptic Syndromes)\tClin Trial Agrmnt (Document type)\tMcl-1 inhibitor AZD5991 (Organic Chemical)\tInhibitors, Reverse Transcriptase (Anti-Retroviral Agents)\tHEMATOXYLIN WEIGERT'S (Organic Chemical)", + "output": "Mcl-1 inhibitor AZD5991 (Organic Chemical)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the ratio of LDH isoenzyme 2 compared to total LDH present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: ERT - Fear Responded as Surprise (ERT Functional Test Question)\tLDH Isoenzyme 2/LDH (Laboratory Procedure)\tDocetaxel/Gemcitabine (Therapeutic or Preventive Procedure)\taeciospore formation (asexual sporulation resulting in formation of a cellular spore)\tRenal artery atherosclerosis (Atherosclerosis)", + "output": "LDH Isoenzyme 2/LDH (Laboratory Procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as gastrin/cholecystokinin type B receptor (447 aa, ~48 kDa) is encoded by the human CCKBR gene. This protein is involved in peptide hormone binding and the regulation of cell proliferation, feeding behavior, and sensory perception.\nConcepts: Fascin (Amino Acid, Peptide, or Protein)\tCCK-B Receptor (Receptor)\tGenotoxic Stress (Cellular Stress)\tBrevibacterium, NOS (Gram-Positive Rods)\tHEAT-EXCHANGER, CARDIOPULMONARY BYPASS (Heat Exchangers)", + "output": "CCK-B Receptor (Receptor)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as a rare inborn error of zinc metabolism characterized by recurrent infections, hepatosplenomegaly, anemia (unresponsive to iron supplementation) and chronic systemic inflammation in the presence of high plasma concentrations of zinc and calprotectin. Patients typically present dermal ulcers or other cutaneous manifestations (for example inflammation) and arthralgia. Severe epistaxis and spontaneous hematomas have also been reported.\nConcepts: HYPERZINCEMIA AND HYPERCALPROTECTINEMIA (Inflammatory disorder)\tDefinitely disagree (Disagree)\tLadda Zonana Ramer syndrome (Hereditary disorder of the integument)\tAR Status (Finding)\tColonic hemorrhage (Finding)", + "output": "HYPERZINCEMIA AND HYPERCALPROTECTINEMIA (Inflammatory disorder)" + }, + { + "input": "Definition: DNA Replication described as telomere Shortening occurs every time linear eukaryotic chromosomes are replicated due to premature stoppage of the DNA polymerase complex in the highly repetitive telomere DNA region several hundred bases before the end of a chromosome.\nConcepts: L-phenylalanine:pyruvate aminotransferase activity (L-phenylalanine aminotransferase activity)\tMaxillary Sinus Cancer Pathologic TNM Finding v6 (Maxillary Sinus Cancer TNM Finding v6)\tPRKA4 (Amino Acid, Peptide, or Protein)\tCranberry Flavor (Food)\tShortening, Telomere (Hematology)", + "output": "Shortening, Telomere (Hematology)" + }, + { + "input": "Definition: Porifera described as a genus of shallow-cupped SPONGES with a broad base in the family Theonellidae. They are characterized by ectosomal spicules dominated by phyllotriaenes.\nConcepts: Theonella (Porifera)\tHPE5 (ZIC2 gene)\tcontingency management (Health Care)\tInsulinoma-Associated Protein 2 Antibody Measurement (Laboratory Procedure)\tUHDRS 1999 Version - Saccade Velocity: Horizontal (UHDRS 1999 Version Clinical Classification Question)", + "output": "Theonella (Porifera)" + }, + { + "input": "Definition: Musculoskeletal System described as the act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.\nConcepts: Retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies (Disease or Syndrome)\twool (Hair)\tMovement functions (Gross motor functions)\tgadolinium texaphyrin complex (Organic Chemical)\tApparent Movement (Mental Process)", + "output": "Movement functions (Gross motor functions)" + }, + { + "input": "Definition: Medical Device described as a truncal orthosis for dysmenorrhea is a device intended to provide pressure to acupressure points on the lower abdomen and lower back for the purpose of reducing menstrual pain symptoms including cramps, abdominal pain and backache.\nConcepts: ORTHOSIS, TRUNCAL, FOR DYSMENORRHEA (Medical Device)\t90Y Colloid (ANTINEOPLASTIC RADIOPHARMACEUTICALS)\tOBSSTP (CDISC SDTM Terminology)\tAdenovirus-expressing TLR5/TLR5 Agonist Nanoformulation M-VM3 (Immunologic Adjuvants)\tEpitheliomas, Basal Cell (Basal Cell Neoplasm)", + "output": "ORTHOSIS, TRUNCAL, FOR DYSMENORRHEA (Medical Device)" + }, + { + "input": "Definition: something described as formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell.\nConcepts: lamellipodium assembly involved in ameboidal cell migration (Cell Function)\tFGF21 (Gene or Genome)\tNyquil (COUGH AND COLD PREPARATIONS)\tAldesleukina (Allergen class)\tSGRQ Past 3 Months Version - Exercise Is Not Safe for Me (Intellectual Product)", + "output": "lamellipodium assembly involved in ameboidal cell migration (Cell Function)" + }, + { + "input": "Definition: Quantitative Concept described as an estimate of the likelihood that a patient has coronary artery disease prior to any testing.\nConcepts: IDDM22 (Gene or Genome)\tPre-Test Probability of Coronary Artery Disease (Quantitative Concept)\tAcute Lateral Myocardial Infarction by ECG Finding (Acute Myocardial Infarction by ECG Finding)\tPseudotsugas (Plant)\tPODCI1-Sports/Phys Function Scale (Intellectual Product)", + "output": "Pre-Test Probability of Coronary Artery Disease (Quantitative Concept)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of cardiac neural crest cell migration involved in outflow tract morphogenesis.\nConcepts: regulation of toll-like receptor 21 signalling pathway (Molecular Function)\tregulation of nurse cell apoptotic process (regulation of apoptotic process involved in development)\tregulation of histone H2A-H2B dimer displacement (regulation of chromatin organization)\tTemperament and personality functions, unspecified (Mental Process)\tdown-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis (negative regulation of animal organ morphogenesis)", + "output": "down-regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis (negative regulation of animal organ morphogenesis)" + }, + { + "input": "Definition: Ovarian cancer stage III described as stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis. N1: Regional lymph node metastasis. M0: No distant metastasis.\nConcepts: polyamines (Amines)\tMosaic trisomy chromosome 12 (Disease or Syndrome)\tchild developmental psychology (Psychology, Developmental)\tStage IIIC Ovarian Cancer AJCC v6 (Ovarian cancer stage III)\tfollicular mixed cell lymphoma, stage II (Neoplastic Process)", + "output": "Stage IIIC Ovarian Cancer AJCC v6 (Ovarian cancer stage III)" + }, + { + "input": "Definition: Assessment scales Ge-Iz described as geriatric Depression Scale (GDS) (Yesavage JA, Brink TL, Rose TL, et al. Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatry Res. 1983;17(1):37-49).\nConcepts: type 3 melanocortin receptor binding (melanocortin receptor binding)\tJaw, Edentulous, Partially (Disease or Syndrome)\tGDS - Geriat depression scale (depression scale)\tVFQ206 (VFQ25-Self Administered Format Questionnaire Question)\tVZOUB (Quantitative Concept)", + "output": "GDS - Geriat depression scale (depression scale)" + }, + { + "input": "Definition: something described as fragmented appearance of the epiphysis of the middle phalanx of the 5th finger.\nConcepts: Fragmentation of end part of the middle bone of the pinky finger (Abnormality of the epiphysis of the middle phalanx of the 5th finger)\tOxymorphone (Laboratory Procedure)\tNeuroglial Cell (Neuroglia)\tC-terminal peptidyl-glutamine amidation (peptidyl-glutamine modification)\tRadiation Biology, Photobiology (Biomedical Occupation or Discipline)", + "output": "Fragmentation of end part of the middle bone of the pinky finger (Abnormality of the epiphysis of the middle phalanx of the 5th finger)" + }, + { + "input": "Definition: Intellectual Product described as marked atrophy; gross telangiectasia.\nConcepts: LRMSC Grade 3, Skin (Disease Grade Qualifier)\tSin pigmentation (Pigmentation)\tcis-zeatin O-beta-D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)\tRoad Rage (Rage)\tHigh Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant (Neoplastic Process)", + "output": "LRMSC Grade 3, Skin (Disease Grade Qualifier)" + }, + { + "input": "Definition: Cell Component described as the ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus.\nConcepts: Cephalometric basion point (Anatomical point)\tSystolic-Diastolic Murmur (abnormal heart sounds/murmurs)\tNuclear chromatin (Chromatin)\t2,3,5-trimethylphenyl methylcarbamate (Acetylcholinesterase Inhibitors)\tCANRFIND (Finding)", + "output": "Nuclear chromatin (Chromatin)" + }, + { + "input": "Definition: Cell development described as the process whose specific outcome is the progression of phialides over time, from its formation to the mature structure. Phialides are specialized cells that bud from the ends of metulae on the conidiophore tip. Chains of conidia, or asexual spores, develop from the phialide tips.\nConcepts: Chronaximeters (Medical Device)\tinterleukin-10 receptor complex (receptor complex)\tSmall Intestine Cancer Pathologic Primary Tumor TNM Finding v8 (Small Intestine Cancer Pathologic TNM Finding v8)\tEhrlichiosis NOS (Tick-borne rickettsiosis)\tdevelopment of secondary sterigmata (developmental process involved in reproduction)", + "output": "development of secondary sterigmata (developmental process involved in reproduction)" + }, + { + "input": "Definition: Exercise described as an exercise that involves movement at a constant rate with a variable force throughout a specified range of motion.\nConcepts: Isotonics (Physical therapy)\tAgencies, International (Organization administrative structures)\tdeformity of hand (Deformity of upper limb)\tSDTM-MSTEST (CDISC SDTM Terminology)\tphosphinothricin biosynthesis (organic substance biosynthetic process)", + "output": "Isotonics (Physical therapy)" + }, + { + "input": "Definition: something described as teaching a patient techniques to assist him or her in complying with his or her therapy and/or treatment.\nConcepts: PDHX gene (Gene or Genome)\tcare cmplins edkshn (Patient counseling education)\tmethanogenesis, from acetate (Molecular Function)\tactin ubiquitination (Molecular Function)\tanterior part of the brainstem (Body Part, Organ, or Organ Component)", + "output": "care cmplins edkshn (Patient counseling education)" + }, + { + "input": "Definition: Eczema, CTCAE described as asymptomatic or mild symptoms; additional medical intervention over baseline not indicated\nConcepts: ALPDH (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tGrade 1 Eczema, CTCAE (Eczema, CTCAE)\tMATERIAL, EXTERNAL AESTHETIC RESTORATION, USED WITH ADHESIVE (Medical Device)\thHK3 (Carrier Proteins)\t1+ (Finding)", + "output": "Grade 1 Eczema, CTCAE (Eczema, CTCAE)" + }, + { + "input": "Definition: Disease or Syndrome described as a lysosomal storage disease characterized by multiple bone formation abnormalities, progressive joint stiffness, developmental abnormalities, hearing loss, hepatosplenomegaly, increased acne, enlarged tongue, and cornea clouding due to accumulation of lipid substances.\nConcepts: Masks, Resuscitator (Medical Device)\tMucolipidosis Type IIIA (Disease or Syndrome)\tnegative regulation of branch elongation involved in ureteric bud branching (negative regulation of branching involved in ureteric bud morphogenesis)\tpyruvate dehydrogenase [NAD(P)+] activity (pyruvate dehydrogenase activity)\tFacilitating ability to perform role (Coping support)", + "output": "Mucolipidosis Type IIIA (Disease or Syndrome)" + }, + { + "input": "Definition: Mustela putorius described as the common domestic ferret, Mustela putorious furo.\nConcepts: alcoholic Wernicke-Korsakoff syndrome (Wernicke-Korsakoff Syndrome)\tMustela putorius subspecies furo (Duplicate concept)\tphytomenadione metabolism (Molecular Function)\tLeft Ventricular Mid Inferolateral Segment (Body Part, Organ, or Organ Component)\tCertificate of Analysis (Intellectual Product)", + "output": "Mustela putorius subspecies furo (Duplicate concept)" + }, + { + "input": "Definition: cellular anatomical entity described as a thread-like connection joining two regions of ectopically paired polytene chromosomes.\nConcepts: GLI-SUFU complex (protein-containing complex)\tlight refraction (Organ or Tissue Function)\tAciduria, Ethylmalonic-Adipic (Mitochondrial Diseases)\tBirth Rates (Quantitative Concept)\tpolytene chromosome ectopic fiber (cellular anatomical entity)", + "output": "polytene chromosome ectopic fiber (cellular anatomical entity)" + }, + { + "input": "Definition: Procedure Kit/Trays, Implant Delivery described as prepackaged collections (either custom or standard) of devices, instruments, and supplies necessary to place bladder support implants (typically solid or mesh slings) in appropriate positions. Items in these kits usually consist of delivery devices (e.g., needles), one or more dilating tubes, and a solid or mesh sling (i.e., the implant). The kits may be supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Bladder support implant delivery kits are intended to facilitate delivery and implantation of a urethral sling for the treatment of stress urinary incontinence; dedicated kits intended to deliver implants according to a specific surgical technique (e.g., transvaginal, transobturator, suprapubic, prepubic) and a particular type of device are also available.\nConcepts: LENS, INTRAOCULAR, TORIC OPTICS (Medical Device)\tup regulation of neural crest cell fate specification (regulation of neural crest cell fate specification)\tBladder Support Implant Delivery Kits (Procedure Kit/Trays, Implant Delivery)\tAnti-La/SSA antibody positivity (Autoimmune antibody positivity)\tFAC016-I Have a Lack of Energy (FACT-L Version 4 Questionnaire Question)", + "output": "Bladder Support Implant Delivery Kits (Procedure Kit/Trays, Implant Delivery)" + }, + { + "input": "Definition: something described as a substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan, which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving 1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.\nConcepts: athetoid cerebral palsy (Dyskinetic syndrome)\tPerformed Composition Relationship (Functional Concept)\tAIDS-related primary CNS lymphoma (site, AIDS-related lymphoma)\tEffusions, Malignant Pleural (Disease or Syndrome)\t1-Methyl-D-tryptophan (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)", + "output": "1-Methyl-D-tryptophan (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)" + }, + { + "input": "Definition: something described as tonsil, each instance of which consists of submucosal masses of lymphoid tissue located beteen some palatoglossal and palatopharyngeal arches on either side of some oropharynx.\nConcepts: periaqueductal gray, ventrolateral division (Body Part, Organ, or Organ Component)\tTonsillar structure (palatine) (Palatine Tonsil)\tmodulation of RNA levels in other organism involved in symbiotic interaction (modulation of process of other organism involved in symbiotic interaction)\tIL 023 (Interleukins)\tDecolorization, Water (Water Purification)", + "output": "Tonsillar structure (palatine) (Palatine Tonsil)" + }, + { + "input": "Definition: Pharmacologic Substance described as the acetate salt of a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C53447\" active clinical trials using this agent.\nConcepts: Octreotide Acetate Salt (Hormone)\tBelgian malinois dog (Canis familiaris)\tDermatopathic Lymphadenopathy (Disorder of lymph node)\tLymph Node Gene Expression Signature (Gene Signature)\tHave You Felt Loved and Wanted (Intellectual Product)", + "output": "Octreotide Acetate Salt (Hormone)" + }, + { + "input": "Definition: lymph nodes described as the first lymph node that is affected by cancer spread from the primary site. Sentinel lymph node biopsy is part of the staging work-up to determine early metastasis to regional lymph nodes in patients with breast carcinoma or melanoma.\nConcepts: Retroviruses, Simian (Retroviridae)\tlarix americana/american lar (Western herbs and natural substances letter L)\tSentinel Node (Body Part, Organ, or Organ Component)\t11q23.2-q23.3 (Chromosome band)\t1 pad per day (Clinical or Research Assessment Answer)", + "output": "Sentinel Node (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: electron transfer activity described as enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis.\nConcepts: Strychnotis / ma qian zi (Plant)\telectron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity (Molecular Function)\ttranslation factor activity (Genetic Function)\tDevelopment Lot (Lot)\tCorchorus (Apeibeae)", + "output": "electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity (Molecular Function)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 12 + 24-Item Interviewer - In the past 30 days, how much difficulty did you have in: Standing for long periods such as 30 minutes?\nConcepts: WD4-Standing for Long Periods (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tdown regulation of methane biosynthetic process from methanethiol (regulation of methane biosynthetic process from methanethiol)\tfield of pharmacy (Health Services)\tConnectivity (Property or Attribute)\tup-regulation of presynaptic terminal assembly (Cell Function)", + "output": "WD4-Standing for Long Periods (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: Menstrual cycle, proliferative phase described as the degeneration and resorption of an OVARIAN FOLLICLE before it reaches maturity and ruptures.\nConcepts: Atresias, Follicular (Organ or Tissue Function)\tbaroreceptor response to decreased systemic arterial blood pressure (positive regulation of systemic arterial blood pressure)\tCalifornia Verbal Learning Test, Children's Version (Research or Clinical Assessment Tool)\tBrushes, Surgical, Bone, Intramedullary, Femoral Canal (Medical Device)\tTimers, Phototherapy (Timer, device)", + "output": "Atresias, Follicular (Organ or Tissue Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as acetate of lead.\nConcepts: Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (Laboratory Procedure)\tIU/mL/(ug/day) (Unit of concentration)\tPlumbum aceticum / lead acetate (Pharmacologic Substance)\tETARACIZUMAB (Monoclonal Antibodies)\tIVD Panels, Human Genetics, Connective Tissue Disorder, Ehlers-Danlos Syndrome, Del/Dup (Medical Device)", + "output": "Plumbum aceticum / lead acetate (Pharmacologic Substance)" + }, + { + "input": "Definition: Cell Component described as a heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains and is involved in NF-kappaB activation. In humans at least, the complex comprises the ubiquitin-conjugating enzyme UBC13 and ubiquitin-conjugating enzyme variant 1A (UEV1A).\nConcepts: Aspirin/Simvastatin/Atenolol/Ramipril/Thiazide Capsule (Agent Affecting Cardiovascular System)\tARTEMIN (Transforming Growth Factor-Beta Family Gene)\tASAH2L (Gene or Genome)\tPolygonatum commutatum / dropberry / sealwort (Western herbs and natural substances letter P)\tUBC13-UEV1A complex (Cell Component)", + "output": "UBC13-UEV1A complex (Cell Component)" + }, + { + "input": "Definition: Aerococcus described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria assigned to the phylum Firmicutes. This bacteria is catalase negative, alpha hemolytic, produces acid from maltose, lactose, sucrose and trehalose, and produces beta glucuronidase. A. viridans is rarely pathogenic in humans but may be associated with urinary tract infections and endocarditis in immunocompromised patients.\nConcepts: Aerococcus viridans Williams et al. 1953 (Approved Lists 1980) emend. Tohno et al. 2014 (Bacterium)\tDisease Outcome or Response (Finding)\tBPI - Areas of Pain (Intellectual Product)\tDEAE-Dextran (Dextrans)\testablishment and maintenance of kinetochore localization (cellular protein-containing complex localization)", + "output": "Aerococcus viridans Williams et al. 1953 (Approved Lists 1980) emend. Tohno et al. 2014 (Bacterium)" + }, + { + "input": "Definition: something described as human KIAA1549 wild-type allele is located in the vicinity of 7q34 and is approximately 150 kb in length. This allele, which encodes UPF0606 protein KIAA1549, may involved in the modulation of the activity of the amygdala, the hypothalamus and other brain regions. Tandem duplication of about 2 Mb at chromosome 7q34 that fuses this gene and the BRAF gene is associated with pilocytic astrocytoma.\nConcepts: positive regulation of extrinsic apoptotic signaling pathway (Molecular Function)\tKIAA1549 wt Allele (Gene or Genome)\tEPIC-26 - Abdominal or Pelvic or Rectal Pain (EPIC-26 Questionnaire Question)\tLife, Physical, and Social Science Technicians (Professional or Occupational Group)\tPregnadienediols (Pregnadienes)", + "output": "KIAA1549 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: detection of humidity described as the series of events in which low humidity is detected and converted into a molecular signal.\nConcepts: Electromyography Feedback (Mental Process)\tRisk for chronic low self-esteem (Finding)\tdetection of low humidity (Cell Function)\tTest, Open Field (Maze Learning)\tpyrimidine ribonucleoside monophosphate breakdown (pyrimidine ribonucleoside monophosphate metabolic process)", + "output": "detection of low humidity (Cell Function)" + }, + { + "input": "Definition: Neoplastic Process described as a myeloid or lymphoid cell neoplasm involving the skin.\nConcepts: Nephrotic Syndrome - ITGA3 Associated (Nephrotic Syndrome)\tmammary gland formation (anatomical structure formation involved in morphogenesis)\tCutaneous Hematopoietic and Lymphoid Cell Neoplasm (Neoplastic Process)\tGenus Deltaretrovirus (Oncornaviruses)\tDiagnosis (Knowledge level: fertility promotion)", + "output": "Cutaneous Hematopoietic and Lymphoid Cell Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: something described as a tablet designed to release active and/or inert ingredient(s) at a controlled rate.\nConcepts: Controlled Release Tablet (Oral Tablet)\tScars (Fibrosis)\tInfection, Babesia Parasite (Zoonoses)\tGenes, Helminth (Gene or Genome)\tDIINDOLYLMETHANE (Phase II Enzymes Inducer)", + "output": "Controlled Release Tablet (Oral Tablet)" + }, + { + "input": "Definition: Molecular Function described as any process that stops, prevents or reduces the frequency, rate or extent of aminoacyl-tRNA ligase activity.\nConcepts: (R)-2-hydroxyisocaproate dehydrogenase activity (Molecular Function)\tdownregulation of aminoacyl-tRNA synthetase activity (negative regulation of ligase activity)\tPQL09-Back Feels Stiff (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)\tIn general, how would you rate your satisfaction with your social activities and relationships (Intellectual Product)\tUPDRS - Complications of Therapy: Clinical Fluctuations - Average Off Periods Per Day (UPDRS Questionnaire Question)", + "output": "downregulation of aminoacyl-tRNA synthetase activity (negative regulation of ligase activity)" + }, + { + "input": "Definition: Focal autonomic seizure described as a type of focal autonomic seizure characterized by pupillary dilatation or contraction as the initial semiological feature.\nConcepts: haptoglobin (Haem metabolism analyses)\tFocal autonomic seizure with pupillary dilation/constriction (Disease or Syndrome)\tactin rod (Cell Component)\tIncrease in potassium content of the diet compared to the assessed baseline intake of potassium for the individual. (Therapeutic or Preventive Procedure)\tHow itchy were you (Intellectual Product)", + "output": "Focal autonomic seizure with pupillary dilation/constriction (Disease or Syndrome)" + }, + { + "input": "Definition: Thoracic Diseases described as a benign inflammation of one or more of the costal cartilages\nConcepts: Premature fusion of phalangeal epiphyses (Abnormal epiphyseal ossification)\tCostalchondritis, NOS (Tietze's Syndrome)\tClinical Stage IVB Esophageal Squamous Cell Carcinoma AJCC v8 (Neoplastic Process)\tOsteosclerosis, generalized (Osteosclerosis)\tWired Communication Problem (Finding)", + "output": "Costalchondritis, NOS (Tietze's Syndrome)" + }, + { + "input": "Definition: Medical Device described as surgical burs designed for excavation, incision, or removal of bone and hard tissue during neurosurgical and microsurgical procedures of the spine. These burs typically consist of a long shank made of steel or tungsten carbide with a well-differentiated working head in appropriate sizes and shapes (e.g., round, cylinder, cone) on the distal end; a tapered, notched, or elongated proximal end to fit into the rotary handpiece; and a long neck that connects the shank to the working part. Dedicated spine surgery burs are available for specific applications (e.g., graft harvesting, impaction); they are used in procedures such as the application of prosthetic plates to the cervical vertebrae (i.e., cervical plating). Spinal burs are usually intended for reuse after sterilization, but disposable (single use) devices are available.\nConcepts: Acid-Base Imbalance (Metabolic Diseases)\thypnoTx smkng ses8xn ndvdl e (Hypnotherapy and/or meditation)\tRight inguinal region (Right lower extremity)\tSpinal Surgery Burs (Medical Device)\tnegative regulation of mast cell activation involved in immune response (negative regulation of mast cell activation)", + "output": "Spinal Surgery Burs (Medical Device)" + }, + { + "input": "Definition: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides described as catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine.\nConcepts: 12 LEAD EASI DOWER TRANSFORMATION (Lead Placement)\tCATH ABLATION (Cardiac therapeutic procedures)\tFactors, RFX Transcription (Amino Acid, Peptide, or Protein)\t(3,5-dichlorophenylurea)acetate amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tIVD Panels, Human Genetics, Overgrowth Syndrome, Mutation (IVD Panels, Human Genetics, Overgrowth Syndrome)", + "output": "(3,5-dichlorophenylurea)acetate amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)" + }, + { + "input": "Definition: something described as this gene plays a role in anti-viral defense.\nConcepts: Mesothelial Cells to Leukocytes Ratio Measurement (Blood Cell Count Ratio Measurement)\tSubstances, Viscoelastic (Specialty Uses of Chemicals)\tschlafen family member 11 (Gene or Genome)\tintracellular chloride channel activity (Molecular Function)\talpha6-beta4 integrin-Shc-Grb2 complex (plasma membrane protein complex)", + "output": "schlafen family member 11 (Gene or Genome)" + }, + { + "input": "Definition: something described as stage IIIB includes: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0); (T4, N1, M0). T1: Tumor invading the lamina propria or submucosa and measuring 2 cm or less. T2: Tumor invading the muscularis propria or measuring more than 2 cm with invasion of the lamina propria or submucosa. T3: Tumor invading through the muscularis propria into subserosal tissue without penetration of overlying serosa. T4: Tumor invading the visceral peritoneum (serosa) or other organs or adjacent structures. N1: Regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Foot Load Alarms (Alarm device)\tStage IIIB Rectal Neuroendocrine Tumor (Neoplastic Process)\tmedium chain fatty acid metabolic process (Fatty Acid Metabolism Pathway)\tpositive regulation of low-density lipoprotein receptor degradation (Cell Function)\tLinear IgA deposits along the epidermal basement membrane zone (Anatomical Abnormality)", + "output": "Stage IIIB Rectal Neuroendocrine Tumor (Neoplastic Process)" + }, + { + "input": "Definition: Neoplastic Syndromes, Hereditary described as high risk of developing malignant rhabdoid tumors that are highly aggressive and rare in the general population. The tumors usually occur in the first year of life, however for those with this syndrome they occur at an average age of 4 to 7 months or even before birth. The tumors spread more quickly than those in children without this predisposition, and affected individuals often do not survive past childhood. More than half of the tumors develop in the cerebellum, but can also occur outside the central nervous system. Caused by mutations in the SMARCB1 gene. These cases are sometimes known as RTPS1. A small number of cases (called RTPS2) are caused by mutations in the SMARCA4 gene. The majority of cases are caused by SMARCB1 gene mutations which may occur in people with no history of the disorder in their family.\nConcepts: Oxide of nitrogen (Nitrogen and nitrogen compound)\tRhabdoid Predisposition Syndrome (Autosomal dominant hereditary disorder)\tPercentage Food Eaten Score 20 (Percentage Food Eaten Scale)\tconventional therapy (Therapeutic procedure)\tD-glucuronate catabolism (glucuronate catabolic process)", + "output": "Rhabdoid Predisposition Syndrome (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Benzodiazepine sedative described as an intermediate in the metabolism of DIAZEPAM to OXAZEPAM. It may have actions similar to those of diazepam.\nConcepts: AAT codon-amino acid adaptor activity (Genetic Function)\tWD4D5 3 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tOvarian Dermoid Cyst with Corticotropin Secreting Adenoma (Ovarian Dermoid Cyst with Secondary Pituitary-Type Tumor)\tInfundibulum of hair follicle (Hair Part)\tdemethyldiazepam (Benzodiazepines)", + "output": "demethyldiazepam (Benzodiazepines)" + }, + { + "input": "Definition: Calcium Channel Blockers described as an injectable phospholipid emulsion containing the butyrate salt of the synthetic, short-acting, dihydropyridine L-type calcium channel antagonist clevidipine with antihypertensive activity. Clevidipine specifically binds to calcium channels in vascular smooth muscle cells, inhibiting the influx of extracellular calcium ions into vascular smooth muscle cells. This results in dilatation of systemic arteries, a decrease in systemic vascular resistance and so a decrease in arterial blood pressure. This agent is metabolized by esterases in the blood and extravascular tissues to an inactive carboxylic acid metabolite.\nConcepts: Clevidipine Butyrate Injectable Emulsion (Calcium Channel Blockers)\tbiopsy node sentinel (Biopsy of lymph node)\tCaT regimen (Regimen Used to Treat Endometrial Carcinoma)\textrahepatic bile duct high grade neuroendocrine carcinoma (Carcinoma of extrahepatic bile duct)\tTRDMT1 Gene (Gene or Genome)", + "output": "Clevidipine Butyrate Injectable Emulsion (Calcium Channel Blockers)" + }, + { + "input": "Definition: Quantitative Concept described as an electrocardiographic measurement of the maximum number of atrial depolarizations (P waves) recorded during a specified period of time, and usually expressed in beats per minute.\nConcepts: SIN (positive regulation of mitotic cytokinetic process)\tECG Maximum Atrial Rate (Quantitative Concept)\tKL-6 (Laboratory Procedure)\tbacillus megaterium (Bacterium)\tScirrhous Adenocarcinomas (Adenocarcinoma)", + "output": "ECG Maximum Atrial Rate (Quantitative Concept)" + }, + { + "input": "Definition: Qualifier value described as an entity, organization, government, corporation, health plan sponsor, or any other financial agent who pays a healthcare provider for the healthcare service rendered to a patient or reimburses the cost of the healthcare service.\nConcepts: Healthcare Payer (Insurance and Payment Issues)\tGVAX Autologous Lung Cancer Vaccine (Pharmacologic Substance)\tAffiliated (Qualitative Concept)\tcubitus; varus (Congenital Abnormality)\tDigital Imaging Systems, Photospot (Medical Device)", + "output": "Healthcare Payer (Insurance and Payment Issues)" + }, + { + "input": "Definition: something described as hyperinsulinism due to mutation(s) in the gene HNF4A, encoding the transcription factor hepatocyte nuclear factor 4-alpha. This condition may progress to diabetes later in life.\nConcepts: Neonatal seizure with bilateral asymmetric automatism (Neonatal electro-clinical motor seizure with automatism)\tHNF4A-Associated Hyperinsulinism (Disease or Syndrome)\tantimonium tartaricum/tartra (Pharmacologic Substance)\turidine diphosphoglucose-o-coumarate glucosyltransferase activity (phenol beta-glucosyltransferase activity)\tnitrotoluene breakdown (toluene-containing compound catabolic process)", + "output": "HNF4A-Associated Hyperinsulinism (Disease or Syndrome)" + }, + { + "input": "Definition: Dermatomycoses described as a fungal infection caused by inhalation of spores of Blastomyces dermatitidis. It presents with flu-like symptoms including fever, chills, cough, pleuritic chest pain and myalgias. It may lead to a chronic granulomatous pulmonary infection and disseminate to other anatomic sites including skin, nervous system and bones.\nConcepts: psychological desensitization (Psychosocial intervention strategy)\tHERNA c.5438A>G (Cell or Molecular Dysfunction)\tmajor help (one or two people, physical), can sit (Finding)\tBlastomycosis NOS (Dermatomycoses)\tmip (Amino Acid, Peptide, or Protein)", + "output": "Blastomycosis NOS (Dermatomycoses)" + }, + { + "input": "Definition: Substance described as chemical neutralization decontamination products including strong bases as active components. These decontaminants may be either common bases or products specially designed for decontamination. Common strong bases used for decontamination include calcium hydroxide (Ca[OH]2), potassium hydroxide ([KOH], caustic soda), and sodium hydroxide (NaOH). Strong base decontaminants are effective for decontamination from nerve agents of the G series and VX, and/or mustard (HD).\nConcepts: Streptococcus gordonii (Streptococcus)\tthird ventricle, mammillary recess (Third ventricle structure)\tAbnormality of the endometrium (Anatomical Abnormality)\tDecontaminants, Chemical Neutralization, Strong Base (Substance)\tExperimental Organism Benign Epithelial Stromal Tumor (Experimental Organism Neoplasm)", + "output": "Decontaminants, Chemical Neutralization, Strong Base (Substance)" + }, + { + "input": "Definition: Quality Indicators, Health Care described as the use of severity-of-illness measures, such as age, to estimate the risk (measurable or predictable chance of loss, injury or death) to which a patient is subject before receiving some health care intervention. This adjustment allows comparison of performance and quality across organizations, practitioners, and communities.\nConcepts: BCR-ABL1 Fusion Gene p190 (Gene or Genome)\tosteoclast fusion (syncytium formation by plasma membrane fusion)\tAdjustment, Risk (Quality Indicators, Health Care)\tBPI Short Form - Pain Interfered with Enjoyment of Life (Intellectual Product)\tPrimary Healthcare Payer at Diagnosis (Primary Healthcare Payer)", + "output": "Adjustment, Risk (Quality Indicators, Health Care)" + }, + { + "input": "Definition: Placental finding described as the weight of the placenta after delivery, with membranes intact and some length of the umbilical cord attached, to the nearest gram, before draining the blood from the specimen.\nConcepts: 3.3 (Study Data Tabulation Model Implementation Guide Version)\tDistress over Physical Problem with Mouth Sores (Intellectual Product)\tEndometrium Tumor (Endometrial disorder)\tLarchs (Plant)\tPlacental Weight NOS (Finding)", + "output": "Placental Weight NOS (Finding)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the vessels carrying deoxygenated blood on the upper side of the foot that originate from the dorsal digital vein creating the dorsal venous arch.\nConcepts: Absent muscle fiber emerin (Finding)\tSet of dorsal metatarsal veins (Venous structure of foot)\tSurgical Retractor Kits, Spine (Medical Device)\tSF-36 v2.0 Standard - Question 11d (Intellectual Product)\tPeginterferon Alfa-2a Regimen (Therapeutic or Preventive Procedure)", + "output": "Set of dorsal metatarsal veins (Venous structure of foot)" + }, + { + "input": "Definition: Myelodysplastic-Myeloproliferative Diseases described as a myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to CHRONIC MYELOID LEUKEMIA, but cytogenetically lacking a PHILADELPHIA CHROMOSOME or bcr/abl fusion gene (GENES, ABL).\nConcepts: Reproductive Body System (Body System)\tunconventional cancer treatments (cancer treatment)\tSubacute myeloid leukemia [obs] (Primary malignant neoplasm)\tHuckleberry Plants (Plant)\tBrushes, Cleaning, Denture, Disabled Person (Denture cleaning brush)", + "output": "Subacute myeloid leukemia [obs] (Primary malignant neoplasm)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway.\nConcepts: Phosphatidylcholine Biosynthesis Pathway (Functional Concept)\tp-biphenylamine (Amines)\tregulation of toll-like receptor 15 signaling pathway (regulation of toll-like receptor signaling pathway)\tEEG with 4-5/second background activity (Finding)\tmuscle spasm (MUSCLE SOFT, TISSUE)", + "output": "regulation of toll-like receptor 15 signaling pathway (regulation of toll-like receptor signaling pathway)" + }, + { + "input": "Definition: Intellectual Product described as decision support systems designed to assist healthcare facilities in making financial decisions by effectively organizing, calculating, planning, and forecasting the performance of the healthcare facility financial data in an electronic format. The main focus of the financial decision support (FDS) systems is accountability with regards to the importance of flexible budgeting and cost, thus providing useful information to all involved in the decision making process. These systems typically consist of a combination of hardware and software. The hardware typically includes dedicated network servers and computers. The software consists of a dedicated software package that is capable of processing information regarding accountability with regard to the importance of flexible budgeting and cost. This can provide useful information to all involved in the decision making process. Financial decision support systems allow facilities to make financial plans that are focused on both the short-term and the long-term financial goals of the facility. They may function as stand-alone systems or may be integrated in a hospital-wide data management information system network.\nConcepts: transferrin transport (Cell Function)\tInformation Systems, Decision Support, Financial (Intellectual Product)\ttyrosine/tyramine antiporter activity (neurotransmitter transmembrane transporter activity)\tE2 (Molecular Function)\tvesicle tethering (cellular component organization)", + "output": "Information Systems, Decision Support, Financial (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cannabigerolate + O2 <=> Delta(9)-tetrahydrocannabinolic acid + hydrogen peroxide.\nConcepts: Delta9-tetrahydrocannabinolate synthase activity (Molecular Function)\tNM 000546.5:c.797G>A (Cell or Molecular Dysfunction)\tEpencephalon (Brain part)\tup regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment (positive regulation of cardiac muscle cell differentiation)\tOsteopathic Physician (Professional or Occupational Group)", + "output": "Delta9-tetrahydrocannabinolate synthase activity (Molecular Function)" + }, + { + "input": "Definition: something described as an endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells. Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases.\nConcepts: alpha-Methylguanidino acetic acid (Amino Acids)\tWaste, Industrial (Environmental Pollution)\tT-Box Domain Proteins (TRANSCRIPTION FACTOR)\tbasic cell groups (Brain)\tPERIVENTRICULAR (Spatial Concept)", + "output": "alpha-Methylguanidino acetic acid (Amino Acids)" + }, + { + "input": "Definition: Cell Component described as the lipid bilayer surrounding a host cell endosome.\nConcepts: In Vivo Result (UML Entity)\thost endosome membrane (host cell membrane)\trhamnose transmembrane transport (hexose transmembrane transport)\tcounselors (mental health worker)\tIntraosseous Infusions (Infusion procedures)", + "output": "host endosome membrane (host cell membrane)" + }, + { + "input": "Definition: Body Space or Junction described as a condyloid synovial joint within the wrist articulating the scaphoid, lunate, and capitate bones.\nConcepts: Pediococcus homari (Aerococcus)\tRevolutions, American (Armed Conflicts)\tBMS-986178 (Pharmacologic Substance)\tSCAPHOID-LUNATE-CAPITATE JOINT (Wrist joint)\tPQL0211 (Intellectual Product)", + "output": "SCAPHOID-LUNATE-CAPITATE JOINT (Wrist joint)" + }, + { + "input": "Definition: something described as breast cancer with extension to the chest wall; invasion or adherence to pectoralis muscle in the absence of invasion of chest wall structures does not qualify as T4.\nConcepts: FIBROMATOSIS, GINGIVAL, WITH ABNORMAL FINGERS, FINGERNAILS, NOSE, AND EARS, AND SPLENOMEGALY (Gingival disorders, signs and symptoms NEC)\tPrimary Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Negative (Neoplastic Process)\tAnalysis, Activation (Chemistry Techniques, Analytical)\tGain of Chromosome 7 (Chromosome 7 Abnormality)\tBreast Cancer pT4a TNM Finding v8 (Finding)", + "output": "Breast Cancer pT4a TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Positive Laboratory Test Result described as an indication that PRLR expression has been detected in a sample.\nConcepts: PRLR Positive (Laboratory or Test Result)\tAugust (Month of the Year)\tGastrointestinal pain (Finding)\tneuregulin binding (Growth Factor Binding)\tshared health service (Health Care Activity)", + "output": "PRLR Positive (Laboratory or Test Result)" + }, + { + "input": "Definition: FACT-C Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Colorectal Version 4 - Social/Family Well-Being: I feel close to my friends.\nConcepts: endocardial cushion to mesenchymal transition (Cell Function)\tandrostene (Androstanes)\tOverriding Aorta (Vascular)\tDesmoplastic nodular medulloblastoma (Glioma)\tFAC008-I Feel Close to My Friends (FACT-C Version 4 Questionnaire Question)", + "output": "FAC008-I Feel Close to My Friends (FACT-C Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as organ component, each instance of which is an inneer layer or region of some organ.\nConcepts: functional bowel syndrome (Other diseases of intestines)\tDacomitinib (D [Preparations])\tLyophilisate for Solution for Injection Dosage Form (Lyophilized powder)\t4-diphosphocytidyl-2C-methyl-D-erythritol kinase activity (kinase activity)\tMedulla (Organ component)", + "output": "Medulla (Organ component)" + }, + { + "input": "Definition: STIMULUS AND CONDITIONING FUNCTIONS described as an environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction.\nConcepts: NILE Glycoprotein (Neural Cell Adhesion Molecules)\tStimulus (Conditioning and Stimulus Functions and Disorders)\theme B catabolic process (Molecular Function)\tNARINGIN (Pharmacologic Substance)\tBreast Implants, Nipple (Medical Device)", + "output": "Stimulus (Conditioning and Stimulus Functions and Disorders)" + }, + { + "input": "Definition: something described as a suggestion, intention or plan, especially one put forward formally or officially.\nConcepts: Kocher Debre Semelaigne syndrome (Endocrine myopathy)\tFatigable weakness of respiratory muscles (Finding)\td.mol/l/(kg/m2) (Quantitative Concept)\tProposal (Document type)\tcal (Lateral ventricle, occipital horn)", + "output": "Proposal (Document type)" + }, + { + "input": "Definition: Boswellia described as a tree that belongs to the incense tree family. The tree's amber-colored resin is used in incense. The resin has anti-inflammatory effects and has been used to treat arthritis, asthma, and ulcerative colitis. It is also being studied in the treatment of brain tumors.\nConcepts: DTHREL (Relationships)\tchelating agents deferiprone (Iron Chelator [EPC])\tfrankincense (Tracheophyta)\tZBTB48 (GLI Family Gene)\tenterococcus (BACTERIA AND RICKETTSIAE)", + "output": "frankincense (Tracheophyta)" + }, + { + "input": "Definition: Finding described as major salivary gland cancer with metastasis in a single ipsilateral lymph node larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-), or in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).\nConcepts: isotype switch recombination to IgG isotypes (Genetic Function)\tFluids, Gingival Crevicular (Body Substance)\tAbnormality of the epiphysis of the distal phalanx of the thumb (Abnormality of the distal phalanx of the thumb)\tupregulation of siderophore synthesis (positive regulation of secondary metabolite biosynthetic process)\tMajor Salivary Gland Cancer cN2 TNM Finding V8 (Major Salivary Gland Cancer Clinical Regional Lymph Nodes TNM Finding v8)", + "output": "Major Salivary Gland Cancer cN2 TNM Finding V8 (Major Salivary Gland Cancer Clinical Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Walking (faster than your usual speed) for 50 steps without stopping.\nConcepts: Required hospitalization (Finding)\tDNA methylation (Biochemical Processes)\tHigh Affinity IL-2 Receptor Subunit Beta Positive (Positive Laboratory Test Result)\tAtrophic macular change (Retinal pigment epithelial abnormality)\tFAC100-Limit: Walk Fast 50 Steps (Intellectual Product)", + "output": "FAC100-Limit: Walk Fast 50 Steps (Intellectual Product)" + }, + { + "input": "Definition: Guanine Nucleotide Exchange Factors described as rho guanine nucleotide exchange factor 12 (1544 aa, ~173 kDa) is encoded by the human ARHGEF12 gene. This protein plays a role in the regulation of Rho-family GTPase- and G-protein coupled receptor-mediated signal transduction.\nConcepts: Rho Guanine Nucleotide Exchange Factor 12 (Guanine Nucleotide Exchange Factors)\tpositive regulation of phosphatidylethanolamine metabolic process (regulation of phosphatidylethanolamine metabolic process)\tERK2 protein, human (Mitogen-Activated Protein Kinases)\tPQL1507 (Intellectual Product)\tsmall RNA 2'-O-methyltransferase (Molecular Function)", + "output": "Rho Guanine Nucleotide Exchange Factor 12 (Guanine Nucleotide Exchange Factors)" + }, + { + "input": "Definition: something described as an abnormality of the incisor characterized by invagination of the enamel, giving a radiographic appearance that suggests a tooth within a tooth.\nConcepts: 18-methylnonadec-1-ene metabolism (Molecular Function)\tdens in dente (Disorder of hard tissues of teeth)\tantibiotics cephalosporins (Cephalosporins)\tHAMD209 (Intellectual Product)\tExternal Liquid Dose Form (Topical Dosage Form)", + "output": "dens in dente (Disorder of hard tissues of teeth)" + }, + { + "input": "Definition: EHMT1 gene described as human EHMT1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 139 kb in length. This allele, which encodes histone-lysine N-methyltransferase, H3 lysine-9 specific 5 protein, plays a role in the modulation of histone methylation. Mutation of the gene is associated with chromosome 9q subtelomeric deletion syndrome.\nConcepts: alpha-hydroxyglutarate (Organic Chemical)\tAnterior chamber RBCs (Finding)\tKISS1R wt Allele (Gene or Genome)\tDKFZp667M072 (EHMT1 gene)\tmalar fracture (Disorder of zygomatic bone)", + "output": "DKFZp667M072 (EHMT1 gene)" + }, + { + "input": "Definition: Non-human disorder described as a horse disease caused by a retrovirus which is transmitted by biting flies. The acute phase symptoms include high fever, anemia, weakness, and swelling of the legs. The subacute phase symptoms include splenomegaly, anemia, and weight loss. The chronic phase symptoms include recurrent fevers and anemia.\nConcepts: CD antigens (Differentiation Antigens)\tGadodiamide-containing product (Paramagnetic contrast media)\tKRN-5500 (Anthracycline Antibiotics)\tEIA - equine infectious anemia (Horse Diseases)\tOrthoses, Upper Limb, Forearm (Medical Device)", + "output": "EIA - equine infectious anemia (Horse Diseases)" + }, + { + "input": "Definition: Video Systems, Microscope described as video systems designed to display in video monitors oocyte images in real time taken from microscope eyepieces. These systems typically consist of an adapter used to attach a video camera (usually a charge-coupled device [CCD]) to the optical system of a microscope, an image processor with dedicated software to process information from the oocytes, a video monitor, and recording devices; the system also uses a microscope with appropriate optical characteristics. In-vitro oocyte imaging video systems provide images of the meiotic and mitotic spindle (i.e., the subcellular structures that release chromosomes between daughter cells during cell division processes known as meiosis and mitosis respectively), the three-layered zona pellucida, and/or other birefringent structures. The systems are used to evaluate the quality of living oocytes (e.g., by monitoring changes in spindle parameters) without the use of stains.\nConcepts: Cyclooxygenase-2 (Prostaglandin-Endoperoxide Synthase)\tCompounds, Methacholine (Quaternary Ammonium Compounds)\tStereotaxic techniques (Neurosurgical Procedures)\tImaging Capsules, Ingestible (Medical Device)\tIn-Vitro Oocyte Imaging Video Systems (Medical Device)", + "output": "In-Vitro Oocyte Imaging Video Systems (Medical Device)" + }, + { + "input": "Definition: EPIC-CP Questionnaire Question described as expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) Bowel symptom score.\nConcepts: ANEMIA APLASTIC (Other deficiency anemias)\tBedaquiline (naphthalene)\tEPIC2-Bowel Symptom Score (Intellectual Product)\tBenign myoepithelioma (Myoepithelioma)\tOral Emulsion in Sachet (Dosage Form and Package Type)", + "output": "EPIC2-Bowel Symptom Score (Intellectual Product)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a form of therapy which involves systems that use \"subtle energy\" fields in and around the body for medical purposes. Examples include Therapeutic Touch, Reiki, Hunna, laying-on-of-hands, external Qi-Gong, etc. Included are: Therapeutic Touch, Healing Science, Healing touch, Natural healing, SHEN, Mariuel, Reiki, Huna, External QiGong, Biorelax. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C15910\" active clinical trials using this agent.\nConcepts: Biopsy of testis (Operation on testis)\tFAC10046 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tBiofields (Energy Therapy)\tNumber of Para-aortic Lymph Nodes Examined (Intellectual Product)\tWhite hair (Finding)", + "output": "Biofields (Energy Therapy)" + }, + { + "input": "Definition: Universal Design described as design process using input from users regarding systems, devices, or software.\nConcepts: 2: 74031790-74058434 (Spatial Concept)\tTesting, Usability (Intellectual Product)\tregulation of phospholipid transport (regulation of anion transport)\tChildhood encephalopathy due to thiamin pyrophosphokinase deficiency (Brain Diseases, Metabolic)\tregulation of lymphatic vessel size (lymphatic vascular process in circulatory system)", + "output": "Testing, Usability (Intellectual Product)" + }, + { + "input": "Definition: something described as a question about the extent to which an individual has or had pain in their jaw.\nConcepts: Lyngbya (Oscillatoriaceae)\tAcute Right Ventricular Myocardial Infarction by ECG Finding (Finding)\tflavanol binding (heterocyclic compound binding)\tHave you had pain in your jaw (Clinical or Research Assessment Question)\tPancreatic enzyme (Pharmacologic Substance)", + "output": "Have you had pain in your jaw (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Young Child Parent Report - In the past one month, how much of a problem has this been for your child: My child takes a long time to eat.\nConcepts: beta-ketoacyl-acyl-carrier-protein synthase III activity (Molecular Function)\tThioredoxin Reductase 2 wt Allele (TXNRD2 gene)\tPQL0815 (Intellectual Product)\tLong Heart Murmur (Heart murmur, categorized by duration)\tFAC01840 (Intellectual Product)", + "output": "PQL0815 (Intellectual Product)" + }, + { + "input": "Definition: something described as an immunohistochemical result of 1 for progesterone receptor expression that is considered intermediate for expression.\nConcepts: Progesterone Receptor Status 1+ (Laboratory or Test Result)\tReference Level, Diagnostic (Reference Standards)\tProtein Reductase, Iron-Sulfur (Amino Acid, Peptide, or Protein)\tPPT (Nucleus of brain)\tPreventions, Tertiary (Public Health Practice)", + "output": "Progesterone Receptor Status 1+ (Laboratory or Test Result)" + }, + { + "input": "Definition: CDRS-R Clinical Classification Question described as children's Depression Rating Scale, Revised (CDRS-R) Subtotal 1 - sum of questions 1 to 6.\nConcepts: Disposable Laparoscopic Clip Appliers (Clip Appliers)\tAnti-ErbB2 Monoclonal Antibody (Pharmacologic Substance)\tCDRS1-Subtotal 1 (CDRS-R Clinical Classification Question)\tAbies sibirica leaf oil (Organic Chemical)\tExtent that Arm, Shoulder, or Hand Problem Limited Work or Other Regular Activities (Clinical or Research Assessment Question)", + "output": "CDRS1-Subtotal 1 (CDRS-R Clinical Classification Question)" + }, + { + "input": "Definition: Immunologic Factor described as a cell-based cancer vaccine composed dendritic cells (DC) that were matured in the presence of a synthetic complex comprised of polyinosinic-polycytidylic acid, poly-L-lysine double-stranded RNA, and carboxymethylcellulose (poly-ICLC), and then pulsed with peptides derived from the tumor-associated antigens (TAAs) cancer/testis antigen NY-ESO-1 and melanoma antigen recognized by T-cells (MART-1/Melan-A), which are linked to the immunostimulant and carrier protein keyhole limpet hemocyanin (KLH), with potential immunostimulatory and antineoplastic activities. Upon intradermal administration, the KLH/NY-ESO-1/MART-1 peptide-pulsed DC vaccine stimulates the immune system to mount an anti-tumor cytotoxic T-lymphocyte (CTL) response against NY-ESO-1/MART-1-expressing tumor cells, which may result in tumor cell lysis. NY-ESO-1 is expressed both in normal testes and on the surfaces of various tumor cells. MART-1 is expressed by melanoma cells. The adjuvant poly-ICLC, a ligand for toll-like receptor-3 (TLR-3), induces the release of cytokines that may help boost the immune response against the TAAs. KLH boosts the immune response against the TAA-expressing tumor cells.\nConcepts: PPS - Periph pulmon stenosis (Vascular)\tEntrapped White Matter Present (Abnormal Tissue Present)\tgrowth retardation-small and puffy hands-eczema syndrome (Disease or Syndrome)\tKLH/NY-ESO-1/Melan-A Peptide-pulsed DC Vaccine (Immunologic Factor)\tOaxaca (Geographic Area)", + "output": "KLH/NY-ESO-1/Melan-A Peptide-pulsed DC Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: Genetic Location described as the portion of the sequence that is described by this test result. EXAMPLE(S): 65 213-215 71 213 152 454 -614 -2055 OTHER NAME(S): NOTE(S):\nConcepts: WIFE (spouse)\tPerformedGeneticObservationResult.geneticLocation (Genetic Location)\tType C Trichothecenes (Trichothecenes)\t1-Naphthalenemethanamine, N-((2E)-6,6-dimethyl-2-hepten-4-yn-1-yl)-N-methyl- (ANTIFUNGALS FOR SYSTEMIC USE)\tAnti-PD-1 Monoclonal Antibody JS001 (Amino Acid, Peptide, or Protein)", + "output": "PerformedGeneticObservationResult.geneticLocation (Genetic Location)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as life Events Checklist for DSM-5 Standard Version test code.\nConcepts: Surgery Information Indicate If any of the Following Medications were Administered During Surgery (Form Directive)\tPhysical medicine iontophoresis -RETIRED- (Electrical or magnetic)\tcob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity (oxidoreductase activity, oxidizing metal ions with flavin as acceptor)\tLEC01TC (CDISC Questionnaire Terminology)\tAdenin riboside (Anti-Arrhythmia Agents)", + "output": "LEC01TC (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other described as plasmablastic lymphoma that arises from the skin.\nConcepts: Cefotetan (Second generation cephalosporin)\tHeat-Shock Proteins, HSP70 (Biologically Active Substance)\tINTLK2 (Laboratory Procedure)\tCorticotropin Releasing Hormone Measurement (Laboratory test of hypothalamic and pituitary hormones)\tPrimary Cutaneous Plasmablastic Lymphoma (Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other)", + "output": "Primary Cutaneous Plasmablastic Lymphoma (Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other)" + }, + { + "input": "Definition: nurse practitioner described as a registered nurse who has received special training and can perform many of the duties of a physician.\nConcepts: Pyloric part of stomach (Stomach part)\tWestern herb and/or natural substance dispensing no charge (Preparing and/or dispensing and/or training services with or without ICD diagnosis)\tregulation of protein localization to ciliary membrane (regulation of protein localization to cell periphery)\tCorneal Transplantation (Incision of cornea)\tRegistered Nurse Practitioner (nurse practitioner)", + "output": "Registered Nurse Practitioner (nurse practitioner)" + }, + { + "input": "Definition: Physiologic Function described as fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern.\nConcepts: Nebenkern assembly (mitochondrion organization)\tRectal Fissure, CTCAE (Finding)\tEndotracheal (Body part)\tGranule for Rectal Suspension Dosage Form (Biomedical or Dental Material)\tHepatocellular Carcinoma Pathologic TNM Finding v8 (Hepatocellular Carcinoma TNM Finding v8)", + "output": "Nebenkern assembly (mitochondrion organization)" + }, + { + "input": "Definition: Fructose-bisphosphate aldolase measurement described as the determination of the amount of aldolase present in a sample.\nConcepts: MIRN1290 (Gene or Genome)\tGrade 1 Facial muscle weakness (Finding)\tTransforming Growth Factor Beta 3 (Biologically Active Substance)\tPIE (Chemical Viewed Functionally)\tAldolase measurement (Clinical Enzyme Tests)", + "output": "Aldolase measurement (Clinical Enzyme Tests)" + }, + { + "input": "Definition: something described as an embryonic structure that helps guide proper descent of gonads into their final positions. It attaches the caudal end of the fetal GONADS to the developing SCROTUM in male and the labium majorum in female. It gives rise to the caudal ligaments of the gonad: the scrotal ligament in male and the uterine round and proper ovarian ligaments in female. It includes morphofunctional equivalent structures in non-mammals.\nConcepts: Mid part of left ventricle (Body Location or Region)\tUprighting (Dental Procedures)\tOB ref.nc (Health Care Activity)\tGubernacula (Embryonic Structures)\tStapling (Reparative closure using a device)", + "output": "Gubernacula (Embryonic Structures)" + }, + { + "input": "Definition: Finding described as an adverse event in a newborn characterized by diffuse rash or target lesions.\nConcepts: Grade 2 Neonatal Rash, Adverse Event (Finding)\tConvenience foods (& [eating observation]) (Food)\tCD137 antigen (Receptor)\tBartter Disease (Renal tubular disorder)\tRHABDOMYOSARCOMA (Primary malignant neoplasm)", + "output": "Grade 2 Neonatal Rash, Adverse Event (Finding)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as personality trait that contrasts adjustment or emotional stability with maladjustment. Experience of anxiety, anger, disgust, sadness, embarrassment, and a variety of other negative emotions.\nConcepts: Neuroticism Traits (Personality Traits)\tCyst of Iris (Mass in head or neck)\tFine Granular Cast Measurement (Laboratory Procedure)\tGrade 5 RoP, AE (Retinopathy of Prematurity, Adverse Event)\tpositive regulation of innate immunity memory response (regulation of innate immunity memory response)", + "output": "Neuroticism Traits (Personality Traits)" + }, + { + "input": "Definition: Cell Component described as a synapse in which the firing of the presynaptic cell reduces the probability of firing of the postsynaptic cell.\nConcepts: Unspecified exotropia (Strabismus and other disorders of binocular eye movements)\tnew infclt 30min (Therapeutic or Preventive Procedure)\tAs Collected Indicator (Qualitative Concept)\tFluorine F18-2-(5-Fluoro-Pentyl)-2-Methyl-Malonic-Acid (Organic Chemical)\tInhibitory Synapse (Chemical synapse)", + "output": "Inhibitory Synapse (Chemical synapse)" + }, + { + "input": "Definition: Sponges, Coelenterates and Echinoderms described as body is flattened and flexible with endoskeleton of ossicles separated by connective tissue; typically with five rays rising from a central disc.\nConcepts: Mutase, Diphosphoglycerate (Enzyme)\tSet of deferent ducts (Seminal duct structure)\tStarfish, NOS (Sponges, Coelenterates and Echinoderms)\tPlasmacytoid Lymphocytes/Leukocytes (Blood Cell Count Ratio Measurement)\tKaposi's Sarcoma of Anus (Kaposi Sarcoma)", + "output": "Starfish, NOS (Sponges, Coelenterates and Echinoderms)" + }, + { + "input": "Definition: Antineoplastic Antibody described as an Fc engineered, humanized anti-CD19 monoclonal antibody directed against the B-cell-specific membrane protein CD19 with potential immunostimulating and antineoplastic activities. Anti-CD19 monoclonal antibody XmAb5574 targets and binds to CD19, thereby depleting and eliminating CD19-expressing B-cells. The modified Fc region of XmAb5574 increases binding affinity to Fc-gamma receptors of effector cells and thereby enhances antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP). CD19 is widely expressed during B-cell development, from pro-B-cell to early plasma cell stages. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95768\" active clinical trials using this agent.\nConcepts: regulation of actomyosin structure organization (Cell Function)\tXMAB-5574 (Pharmacologic Substance)\tSMEI (Disease or Syndrome)\tB cell tolerance induction in mucosal-associated lymphoid tissue (Cell Function)\tBlood Glucose Control (Therapeutic or Preventive Procedure)", + "output": "XMAB-5574 (Pharmacologic Substance)" + }, + { + "input": "Definition: Radioconjugate described as a radioconjugate containing a bombesin (BBN) peptide analog, derived from an unspecified GRPR antagonist (MATBBN) that targets the gastrin-releasing peptide receptor (GRPR), and is linked to the radionuclide fluorine F 18 (18F), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), through a method that first couples 18F to aluminum (Al), with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of fluorine F 18-Al-NOTA-MATBBN, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a seven-transmembrane G protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers. Bombesin is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (GRPR).\nConcepts: 18F-Al-NOTA-MATBBN (Indicator, Reagent, or Diagnostic Aid)\tAllopathic & Osteopathic Physicians; Emergency Medicine, Hospice and Palliative Medicine (Professional or Occupational Group)\tAdrenal Cortical Carcinoma pT1 TNM Finding v8 (Finding)\tVitreous snowballs (Vitreous inflammatory infiltrate)\tShields, X-Ray, Thyroid, Articulated Arm (Shields, X-Ray, Thyroid)", + "output": "18F-Al-NOTA-MATBBN (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Tectiviridae described as bacteriophage and type species in the genus Tectivirus, family TECTIVIRIDAE. They are specific for Gram-negative bacteria.\nConcepts: Intermediate Fiber (Skeletal Myocytes)\texsanguination (Death)\tInformation Systems, Data Management, Radiology, Mammography (Radiology Information Systems)\tPRD1, Phage (Coliphages)\tabsence oxygen (Metabolic finding)", + "output": "PRD1, Phage (Coliphages)" + }, + { + "input": "Definition: Finding described as an abnormal increase in the concentrationl of small fucosylated oligosaccharides in the urine.\nConcepts: Increased urinary fucosylated oligosaccharide (Finding)\tPlant, Blueberry (Plant)\tAtrial branch of circumflex coronary artery (Body Part, Organ, or Organ Component)\tHydrocarbon, NOS (Hydrocarbons, Halogenated)\tLack of Appetite Score 3 (Lack of Appetite Visual Analogue Scale)", + "output": "Increased urinary fucosylated oligosaccharide (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in neurotransmission and ligand-gated ion transport.\nConcepts: GAMMA-AMINOBUTYRIC ACID RECEPTOR, ALPHA-3 (Gene or Genome)\tDefect speech (language or speech disorder)\tFusiform aortic arch aneurysm (Aneurysm of aortic arch)\tDevice-In-Use Test Code (CDISC SDTM Terminology)\tSpecificity (Quantitative Concept)", + "output": "GAMMA-AMINOBUTYRIC ACID RECEPTOR, ALPHA-3 (Gene or Genome)" + }, + { + "input": "Definition: Hyperlipidemia described as an abnormal increase in the level of lipoprotein cholesterol in the blood.\nConcepts: erythropoietin-mediated signaling pathway (Cell Function)\tHYPERLIPOPROTEINEMIA (Hyperlipoproteinemias)\tstreptavidin (Amino Acid, Peptide, or Protein)\tLiquid Ventilation (Intermittent Positive-Pressure Ventilation)\tGlutamine measurement, NOS (Amino acids measurement)", + "output": "HYPERLIPOPROTEINEMIA (Hyperlipoproteinemias)" + }, + { + "input": "Definition: Virus described as a genus of enveloped, spherical or pleomorphic viruses with a capsid that is surrounded by an amorphous tegument, in the family Herpesviridae. The genome is composed of monopartite, linear double-stranded DNA. Roseoloviruses are found in humans and cause Roseola in humans.\nConcepts: camomile (Flower Essences)\tpeptide-acetyl-CoA secondary active transmembrane transporter activity (porter activity)\tGenus Roseolovirus (Cytomegalovirus)\tADL02-Total ADCS-ADL Score (ADCS-ADL Severe Dementia Questionnaire Question)\t1H-Imidazole, 1-(2-(ethylsulfonyl)ethyl)-2-methyl-5-nitro- (Nitroimidazole Antimicrobial [EPC])", + "output": "Genus Roseolovirus (Cytomegalovirus)" + }, + { + "input": "Definition: something described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week how much of the time have you: felt clearheaded?\nConcepts: Completing a complex task (Undertaking a single task)\tDAD01-Dress Completely (DAD Questionnaire Question)\tQLES114 (Intellectual Product)\tInhibitors, Phosphodiesterase 3 (Pharmacologic Substance)\tCALNB1 (Genes, Regulator)", + "output": "QLES114 (Intellectual Product)" + }, + { + "input": "Definition: Genes, Regulator described as this gene is involved in Golgi maintenance.\nConcepts: Low Natural Killer Cell Activity (Laboratory or Test Result)\tRET-FUSED GENE 5 (Gene or Genome)\tMajor Salivary Gland Cancer cN2c TNM Finding V8 (Major Salivary Gland Cancer cN2 TNM Finding V8)\tCSS0521A (C-SSRS Already Enrolled Subjects Questionnaire Question)\tOccupational exposure (Environmental and Occupational Exposure)", + "output": "RET-FUSED GENE 5 (Gene or Genome)" + }, + { + "input": "Definition: Pteridoideae described as a plant genus of the family PTERIDACEAE. Members contain entkaurane DITERPENES. The name is similar to bracken fern (PTERIDIUM).\nConcepts: Age-related posterior subcapsular cataract (Finding)\tFern, Brake (Plant)\tSebocyte (Cell)\tFeels no pain (Pain threshold - finding)\tHuman Papillomavirus-31 (Human papillomavirus 16)", + "output": "Fern, Brake (Plant)" + }, + { + "input": "Definition: regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway described as any process that stops, prevents, or reduces the frequency, rate, or extent of the nucleotide-binding oligomerization domain containing 2 (NOD2) pathway.\nConcepts: DNA Synthesis Induction (Genetic Function)\tnegative regulation of NOD2 signaling pathway (negative regulation of nucleotide-binding oligomerization domain containing signaling pathway)\ttargetCodingSystem (Code)\tesophagus; burn (Burn injury)\tflavin-adenine dinucleotide metabolic process (coenzyme metabolic process)", + "output": "negative regulation of NOD2 signaling pathway (negative regulation of nucleotide-binding oligomerization domain containing signaling pathway)" + }, + { + "input": "Definition: Occupation or Discipline described as the science that deals with the ocean and its phenomena.\nConcepts: detection of endogenous biotic stimulus (detection of biotic stimulus)\tClinical Specialist in Wound, Ostomy, and Continence (Professional or Occupational Group)\tPASSER, WIRE, ORTHOPEDIC (Medical Device)\tOceanographies (Geography)\talpha-aminoadipate acetyltransferase activity (N-acetyltransferase activity)", + "output": "Oceanographies (Geography)" + }, + { + "input": "Definition: Injury or Poisoning described as a full thickness wound of the eyewall (sclera and cornea). (Birmingham Eye Trauma Terminology System (BETTS))\nConcepts: Vertebral cementoplasty (Orthopedic Procedures)\tNucleus pulvinaris medialis zentralis (Body Part, Organ, or Organ Component)\tRenovascular disorders (Classification)\tOpen globe injury (Eye Injuries)\tIPA0320B (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)", + "output": "Open globe injury (Eye Injuries)" + }, + { + "input": "Definition: something described as catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+.\nConcepts: Management of composition of enteral nutrition (Enteral feeding management)\tLaparoscope Holders (Manufactured Object)\tBone, Tarsal (Ankle region)\tLoss of PMS1 Protein Homolog 2 Expression (Protein Deregulation)\tsuccinyl semialdehyde dehydrogenase (NADP+) activity (Molecular Function)", + "output": "succinyl semialdehyde dehydrogenase (NADP+) activity (Molecular Function)" + }, + { + "input": "Definition: Acute Megakaryocytic Leukemias described as a rare subtype of acute myeloid leukemia evolving from primitive megakaryoblasts. []\nConcepts: Salivary Gland Virus (Genetic Antimicrobial Resistance)\tDeglutitions (Gastrointestinal Process)\tMegakaryocytic Leukemia (OTHER LEUKEMIAS)\tBCR Downstream Signaling 1 (Adaptor Proteins, Signal Transducing)\tneurotransmitter receptor metabolic process (Molecular Function)", + "output": "Megakaryocytic Leukemia (OTHER LEUKEMIAS)" + }, + { + "input": "Definition: something described as the initial formation of a blastocyst from a solid ball of cells known as a morula.\nConcepts: IL-3 secretion (Cell Function)\tcentral neuron (Neurons)\tInformed Consent Process Deviation (Protocol Deviation)\tHas any Rheumatic or Connective Tissue Disease (Findings-Based Question)\tblastocyst formation (Physiologic Function)", + "output": "blastocyst formation (Physiologic Function)" + }, + { + "input": "Definition: Injury, Poisoning and Procedural Complications, CTCAE described as a finding of leakage due to breakdown of an esophageal anastomosis (surgical connection of two separate anatomic structures).\nConcepts: Software, Computer (computer technology)\tcentral canal (Region of ventricular system of neuraxis)\tToothbrushes, Manual, Gingiva/Interproximal (Manual toothbrush)\tEsophageal anastomotic leak (Injury, Poisoning and Procedural Complications, CTCAE)\tPAPILLA, DUODENAL (Body Part, Organ, or Organ Component)", + "output": "Esophageal anastomotic leak (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (4-coumaroyl)acetyl-CoA + 4-coumaryl-CoA + H2O <=> bisdemethoxycurcumin + 2 coenzyme A + carbon dioxide.\nConcepts: Lymphoid Tissue (Tissue)\tPsychotherapeutic Transference (Psychotherapy)\tdemethoxycurcumin synthase (transferase activity, transferring acyl groups other than amino-acyl groups)\tProstheses, Joint, Wrist, Carpal Lunate (Prostheses, Joint, Wrist, Carpal Component)\tNursing, Evidence-Based (Evidence-Based Practice)", + "output": "demethoxycurcumin synthase (transferase activity, transferring acyl groups other than amino-acyl groups)" + }, + { + "input": "Definition: Dietary Intake described as an indication that the patient does not consume caffeine on a regular basis.\nConcepts: Caffeine Not Routinely Consumed (Finding)\tFreezers, Laboratory, Flammable Material (Laboratory freezer)\tAnti-T-Cell Ricin A Chain Immunotoxin (Immunologic Factor)\tHLA-A*2402-restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 multipeptide vaccine (Amino Acid, Peptide, or Protein)\tModern History (Temporal Concept)", + "output": "Caffeine Not Routinely Consumed (Finding)" + }, + { + "input": "Definition: malachite green described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.\nConcepts: cellular response to polypeptide hormone stimulus (Cell Function)\tnitrogenase complex (Cell Component)\tMethyl violet 2B (Tissue Stains)\tNasopharyngeal Cancer pN3a TNM Finding v7 (Nasopharyngeal Cancer pN3 TNM Finding v6)\tvaginal adenocarcinoma (Malignant Vaginal Neoplasm)", + "output": "Methyl violet 2B (Tissue Stains)" + }, + { + "input": "Definition: regulation of gliogenesis described as any process that modulates the frequency, rate or extent of glia cell differentiation.\nConcepts: Keratinisation (BIOLOGICAL FUNCTIONS AND UNITS OF THE INTEGUMENTARY SYSTEM)\tUDP:glucose:BA glucosyltransferase activity (phenol beta-glucosyltransferase activity)\tAnaplastic Large Cell Lymphoma, Signet Ring-Like Subtype (Ki-1+ Anaplastic Large Cell Lymphoma)\tregulation of neuroglia differentiation (Cell Function)\tEpidermal Growth Factor Receptor M766 A767insASV (EGFR Protein Variant)", + "output": "regulation of neuroglia differentiation (Cell Function)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a circulatory system, cardiac monitoring or testing device, equipment or supply code. Use associated HCPCS II codes to bill for monitoring or testing device(s), equipment or supply(ies). This code is used for scope-of-practice mapping, not for billing.\nConcepts: TLA519 (GNLY gene)\t20q13.1-q13.2 (Cell Component)\tGrade 2 Hypopituitarism (Hypopituitarism, CTCAE)\tGROWTH FACTOR RECEPTOR BOUND PROTEIN 007 (Biologically Active Substance)\tNon-specified HCPCS II circulatory system, cardiac monitoring or testing device, equipment or supply reference code no charge (Tracking code use with or without ICD diagnosis)", + "output": "Non-specified HCPCS II circulatory system, cardiac monitoring or testing device, equipment or supply reference code no charge (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: T1-DDS Questionnaire Question described as diabetes Distress Scale for Adults with Type 1 Diabetes - Over the past month, please indicate the degree to which each of the following may have been a problem for you: Feeling worried that I will develop serious long-term complications, no matter how hard I try.\nConcepts: Item Response Theory (Intellectual Product)\tDDS01-Worried Develop Complications (T1-DDS Questionnaire Question)\tApical two chamber view (Cardiac imaging views)\tAldrin Epoxidase Measurement (Protein or Enzyme Type Measurement)\tnegative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly (negative regulation of mitotic actomyosin contractile ring assembly)", + "output": "DDS01-Worried Develop Complications (T1-DDS Questionnaire Question)" + }, + { + "input": "Definition: something described as a composite substructure of the ventral lateral nucleus of the thalamus. It includes the anterior ventral lateral nucleus, area X and the posterior ventral lateral nucleus ( Walker-1938 ).\nConcepts: Grade 4 Social circumstances - Other, specify (Finding)\tUsed Text Message-Based Smoking Cessation Program (Clinical or Research Assessment Answer)\tOrthotopic (General site descriptor)\tinhibition by virus of host DDX58 activity (Organism Function)\tNucleus ventralis lateralis (Body Part, Organ, or Organ Component)", + "output": "Nucleus ventralis lateralis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a type 1 neuropeptide Y receptor.\nConcepts: Anti-Epithelial Glycoprotein-2 Immunotoxin MOC31-PE (Pharmacologic Substance)\ttype 1 neuropeptide Y receptor binding (neuropeptide Y receptor binding)\tHALOFENATE (Phenoxyacetates)\txenobiotic detoxification by transmembrane export across the cell outer membrane (xenobiotic transport)\tUreteral Squamous Cell Carcinoma (Squamous cell carcinoma)", + "output": "type 1 neuropeptide Y receptor binding (neuropeptide Y receptor binding)" + }, + { + "input": "Definition: Disorder of aromatic amino acid metabolism described as an autosomal recessive condition caused by mutation(s) in the DDC gene, encoding aromatic-L-amino-acid decarboxylase. It is characterized by combined serotonin and catecholamine deficiency, resulting in severe neurologic dysfunction usually beginning in infancy or childhood.\nConcepts: Deficiency of tryptophan decarboxylase (Disorder of aromatic amino acid metabolism)\tStage IIIA Gallbladder Cancer AJCC v8 (Stage III Gallbladder Cancer AJCC v8)\tpancreatic E cell development (Cell development)\tseptin cytoskeleton organization (Cell Function)\tAttenuation Coefficient (Coefficient)", + "output": "Deficiency of tryptophan decarboxylase (Disorder of aromatic amino acid metabolism)" + }, + { + "input": "Definition: something described as stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque +/- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque +/- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.\nConcepts: MRX47 (PAK3 gene)\tADNI AVLT - List A Recall 1 Word 13 (Intellectual Product)\tDENTURE, PLASTIC, TEETH (Medical Device)\tL-glutamate import into mitochondrion (L-glutamate transmembrane transport)\tStage IV Mycosis Fungoides and Sezary Syndrome (stage, mycosis fungoides/Sezary syndrome)", + "output": "Stage IV Mycosis Fungoides and Sezary Syndrome (stage, mycosis fungoides/Sezary syndrome)" + }, + { + "input": "Definition: Ear part described as a type of sensory epithelial cell, located in the inner ear, that use hair-like projections called stereocilia to detect sound waves and transform them into neural signals that can be interpreted by the brain.\nConcepts: Hair Cell, Auditory (Labyrinth)\tCT head with contrast (Computed Tomography with Contrast)\tPyrimidine Dimer (Nucleic Acid, Nucleoside, or Nucleotide)\tVulvar Adenocarcinoma (Vulvar Neoplasms)\tRestrictive partial external ophthalmoplegia (Restrictive external ophthalmoplegia)", + "output": "Hair Cell, Auditory (Labyrinth)" + }, + { + "input": "Definition: Molecular Function described as catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a quinone or similar compound.\nConcepts: vandalism (Impulsive Behavior)\tGastric Fundus Carcinoma In Situ (Neoplastic Process)\toxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor (oxidoreductase activity, acting on the CH-NH2 group of donors)\tSpermatic cord anastomotic leak (Anastomotic Leak)\t8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity (nucleoside-triphosphate diphosphatase activity)", + "output": "oxidoreductase activity, acting on the CH-NH2 group of donors, with a quinone or similar compound as acceptor (oxidoreductase activity, acting on the CH-NH2 group of donors)" + }, + { + "input": "Definition: regulation of transport described as any process that modulates the frequency, rate or extent of transport across the blood-brain barrier.\nConcepts: Focal impaired awareness vocal automatism seizure (Focal impaired awareness automatism seizure)\tDis of glycine cleav enz compl (Encephalopathies)\tChemokine (C-X-C Motif) Ligand 13 (B-Cell Chemoattractant) Gene (CXCL13 gene)\tregulation of transport across blood-brain barrier (regulation of system process)\t2p23.3 (Cell Component)", + "output": "regulation of transport across blood-brain barrier (regulation of system process)" + }, + { + "input": "Definition: Neoplastic Process described as ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S).\nConcepts: IL-20 receptor complex location (Cell Component)\t3-beta-D-glucosyl-D-glucose:phosphate alpha-D-glucosyltransferase activity (hexosyltransferase activity)\tCOATING, FILLING MATERIAL, RESIN (Biomedical or Dental Material)\tmantle cell lymphoma stage III (Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma)\tSOAPR1-Attended AA or NA Meeting (SOAPP-R Questionnaire Question)", + "output": "mantle cell lymphoma stage III (Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as therapies alone or in any combination, involved in rehabilitating and treating stroke patients; may include drug therapies ie, neuroprotectants, anticoagulants, etc; coordinate with other applicable therapy or drug terms.\nConcepts: Encode (Action)\tByte (Miscellaneous Unit)\ttherapy stroke (Therapeutic or Preventive Procedure)\tmeiotic cell cycle control (regulation of cell cycle phase transition)\tGastrointestinal Tract, Upper (Digestive System Part)", + "output": "therapy stroke (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Biological Assay described as a laboratory assay to determine the status of the GNA11 gene which encodes guanine nucleotide-binding protein subunit alpha-11.\nConcepts: hobbies (recreational activity)\tGNA11 Gene Expression Analysis (Biological Assay)\tDDS0214 (PARENT-DDS Questionnaire Question)\tAdjuvant Post-operative Immunological Therapy Was Not Administered (Finding)\tMyxopapillary Ependymoma (Neoplastic Process)", + "output": "GNA11 Gene Expression Analysis (Biological Assay)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter L described as fang feng\nConcepts: ledebouriella seseloides/fan (Oriental herbs and natural substances letter L)\tdAMP breakdown (purine deoxyribonucleoside monophosphate catabolic process)\t7: 79920284-79948387 (Chromosome 7 Physical Location)\tDiagonal earlobe crease (Abnormality of earlobe)\tglycine synthase complex (Cell Component)", + "output": "ledebouriella seseloides/fan (Oriental herbs and natural substances letter L)" + }, + { + "input": "Definition: something described as the sum of the longest diameters of non-nodal target and new measurable lesions, and the short axes of nodal target and new measurable lesions.\nConcepts: pollution related respiratory disorder (Respiration Disorders)\tTotal Measured Tumor Burden (Quantitative Concept)\tdesigner drug (AOD substances in general)\tPre-adolescent age (Temporal Concept)\tMetalloproteinase, MMP-16 (Amino Acid, Peptide, or Protein)", + "output": "Total Measured Tumor Burden (Quantitative Concept)" + }, + { + "input": "Definition: something described as emory Treatment Resistance Interview for PTSD - Psychotherapy total points.\nConcepts: thyroiditis; chronic (Thyroiditis)\tMOL STRUCT (chemical bonding, molecular interaction)\tdiagnostic procedures (Dental Procedures)\tETRP0102 (E-TRIP Clinical Classification Question)\tProduct containing tamoxifen (Oncology drugs)", + "output": "ETRP0102 (E-TRIP Clinical Classification Question)" + }, + { + "input": "Definition: Short Tandem Repeat described as a dinucleotide repeat on chromosome 17 that serves as a marker for microsatellite instability in colorectal cancers.\nConcepts: Gluconates (Organic Chemical)\tD17S250 Dinucleotide Repeat (Gene or Genome)\tartemisia absinthium/wormwoo (Plant)\tRXR (Amino Acid, Peptide, or Protein)\trecombinant Saccharomyces cerevisia-CEA(610D) vaccine GI-6207 (Amino Acid, Peptide, or Protein)", + "output": "D17S250 Dinucleotide Repeat (Gene or Genome)" + }, + { + "input": "Definition: Activity described as supply what is desired or needed.\nConcepts: Supplied (Activity)\tEPIC2-Best Describes Urinary Control (EPIC-CP Questionnaire Question)\tExtein (Amino Acid, Peptide, or Protein)\tLower jaw shifted to one side (Disorder of skull)\tTracheoesophageal Fold (Other Embryologic Structure)", + "output": "Supplied (Activity)" + }, + { + "input": "Definition: Organic Chemical described as carcinogenic organochlorine insecticide.\nConcepts: Puebla (Mexican State)\tmirex/kepone (Organochlorine insecticide)\tCupressus sempervirens L. (Cupressus)\tHair Coloring Agents (Hair Preparations)\tX-linked immune dysregulation, polyendocrinopathy, enteropathy syndrome (Immunodeficiency associated with chromosomal abnormality)", + "output": "mirex/kepone (Organochlorine insecticide)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.\nConcepts: Sarcomatoid Features (Mesenchymal Differentiation)\tCDR0108 (Intellectual Product)\tresponse to peptide hormone (Cell Function)\tComplete (General adjectival modifier)\tGABAergic Modulators (Pharmacologic Substance)", + "output": "response to peptide hormone (Cell Function)" + }, + { + "input": "Definition: mitochondrial DNA metabolic process described as any DNA biosynthetic process that is involved in mitochondrial DNA replication.\nConcepts: Protein kinase cAMP-dependent type I regulatory subunit beta-related neurodegenerative dementia with intermediate filaments (Autosomal dominant hereditary disorder)\tDNA biosynthetic process involved in mitochondrial DNA replication (DNA synthesis involved in DNA replication)\tAide, Pharmacists' (Allied Health Personnel)\tMargo inferomedialis (Anatomical line)\tADNI AVLT - List A 30 Min Delay Recall Word 12 (Intellectual Product)", + "output": "DNA biosynthetic process involved in mitochondrial DNA replication (DNA synthesis involved in DNA replication)" + }, + { + "input": "Definition: Amino acids measurement described as a measurement of the threonine in a biological specimen.\nConcepts: synchronous neurotransmitter secretion (neurotransmitter release)\tThreonine Test (Amino acids measurement)\tOsteocraniosplenic syndrome (Congenital anomaly of skeletal bone)\tNucleus centralis thalami, magnocellularis (Body Part, Organ, or Organ Component)\tBiotinidase (Propionate and methylmalonate metabolism disorder marker)", + "output": "Threonine Test (Amino acids measurement)" + }, + { + "input": "Definition: Sea Cucumbers described as a genus of large SEA CUCUMBERS possessing the primitive radial configuration of podia in all five ambulacral areas.\nConcepts: Cucumarias (Cucumariidae)\tresponse to oxidopamine (response to catecholamine)\tGibberellas (Fungus)\tHPV 16 E6 peptides vaccine/candida albicans extract (Pharmacologic Substance)\tCompactors (Medical Device)", + "output": "Cucumarias (Cucumariidae)" + }, + { + "input": "Definition: something described as specifies whether the study subject gave official consent by signing the official consent form. EXAMPLE(S): OTHER NAME(S): NOTE(S): Derived from the existence of PerformedStudySubjectMilestone.dateRange WHERE PerformedActivity > DefinedActivity.nameCode = \"obtain informed consent\".\nConcepts: GITRL RNA-transfected autologous dendritic cell vaccine (Cell)\tDamon Runyon Cancer Research Foundation (Professional Organization or Group)\tEstimated Glomerular Filtration Rate (Laboratory Procedure)\tMedial vestibulospinal tract of spinal cord (Tract of spinal cord)\tPerformed Study Subject Milestone Informed Consent Indicator (Functional Concept)", + "output": "Performed Study Subject Milestone Informed Consent Indicator (Functional Concept)" + }, + { + "input": "Definition: Neoplastic Syndromes, Hereditary described as an autosomal dominant hereditary neoplastic syndrome characterized by the development of colorectal carcinoma and a high risk of developing endometrial carcinoma, gastric carcinoma, ovarian carcinoma, renal pelvis carcinoma, and small intestinal carcinoma. Patients often develop colorectal carcinomas at an early age (mean, 45 years). In the majority of the cases the lesions arise from the proximal colon. At the molecular level, high-frequency microsatellite instability is present. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8494\" active clinical trials using this agent.\nConcepts: ORCAM Gene (Gene or Genome)\tAV valve morphogenesis (heart valve morphogenesis)\tColon Cancer, Familial Nonpolyposis (Neoplastic Syndromes, Hereditary)\tregulation of fibroblast growth factor receptor signalling pathway involved in neural plate anterior/posterior pattern formation (Molecular Function)\tTREPHINE, MANUAL, OPHTHALMIC (Medical Device)", + "output": "Colon Cancer, Familial Nonpolyposis (Neoplastic Syndromes, Hereditary)" + }, + { + "input": "Definition: something described as all components of paleocortex except the piriform area, which is different in origin phylogenetically and ontogenetically ( Stephan-1975 ).\nConcepts: Dorsoventral (Anatomy Qualifier)\tSupplemental Qualifiers for Respiratory Test Results (Intellectual Product)\tCutaneous nodular amyloidosis (Amyloidosis, Primary Cutaneous)\tNEOPL MALE GENITAL (reproductive system disorder)\tsemicortex (Body Part, Organ, or Organ Component)", + "output": "semicortex (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Corticosteroid [EPC] described as a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Flurandrenolide exerts its effects by interacting with specific cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.\nConcepts: 2S Storage Albumins, Plant (Amino Acid, Peptide, or Protein)\t150-1E5 ENTEROBACTERIACEAE (Proteobacteria)\t6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with Acetone (Glucocorticoids)\tCKBB Positive (Laboratory or Test Result)\tGuardianship (Legal Processes)", + "output": "6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with Acetone (Glucocorticoids)" + }, + { + "input": "Definition: Short distal phalanx of finger described as hypoplasia of all of the distal phalanx of finger.\nConcepts: Shortening of all distal phalanges of the fingers (Foot)\tlestaurtinib (Pharmacologic Substance)\tVascular Targeted Phototherapy (Photochemotherapy)\tColoanal Anastomosis (Anastomosis - action)\tMitochondrial Inner Membrane (MITOCHONDRION AND ASSOCIATED STRUCTURES)", + "output": "Shortening of all distal phalanges of the fingers (Foot)" + }, + { + "input": "Definition: something described as acinetobacter calcoaceticus serological reagents are devices that consist of Acinetobacter calcoaceticus antigens and antisera used to identify this bacterium from cultured isolates derived from clinical specimens. The identification aids in the diagnosis of disease caused by the bacterium Acinetobacter calcoaceticus and provides epidemiological information on disease caused by this microorganism. This organism becomes pathogenic in patients with burns or with immunologic deficiency, and infection can result in sepsis (blood poisoning).\nConcepts: ANTISERA, ACINETOBACTER CALCOACETICUS, ALL VARIETIES (Indicator, Reagent, or Diagnostic Aid)\tPersonal or Social Life Hampered Due to Hearing Problem (Intellectual Product)\tCystadenoma, NOS (Benign adenomatous neoplasm - category)\tEczema NOS (Skin, Human)\tSun Protection Factors (Radiometry)", + "output": "ANTISERA, ACINETOBACTER CALCOACETICUS, ALL VARIETIES (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Vulvar Cancer Pathologic Primary Tumor TNM Finding v7 described as vulvar cancer with tumor of any size with extension to any of the following: upper/proximal 2/3 urethra, upper/proximal 2/3 vagina, bladder mucosa, rectal mucosa, or fixed to pelvic bone.\nConcepts: Area 28 of Brodmann (Parahippocampal Gyrus)\tGiemsa stain (Organic Chemical)\tVulvar Cancer pT3 TNM Finding v7 (Finding)\tNear esotropia (Esotropia)\tTesticular Cancer cNX TNM Finding v7 (Finding)", + "output": "Vulvar Cancer pT3 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Laboratory or Test Result described as an indication that the expression of a fusion containing ERBB family gene sequences have been detected in a sample.\nConcepts: ErbB Receptor Family Gene Fusion Positive (Rearrangement Detected)\tDemyelinating neuropathy (Demyelinating Diseases)\tGrade 4 Apnea (Finding)\tActivity Status (Status)\tFertility, NOS (Sexual function)", + "output": "ErbB Receptor Family Gene Fusion Positive (Rearrangement Detected)" + }, + { + "input": "Definition: Medicinal product categorized by structure described as a mixture of liquid paraffinic, naphthenic and polycyclic aromatic hydrocarbons obtained from petroleum in which the amount and types of aromatic hydrocarbons is dependent on the treatment process. Untreated and mildly treated mineral oils contain the highest amount of aromatic and unsaturated compounds and are primarily used as a lubricant base oil to produce further refined oil products. Exposure to these types of mineral oils can cause rapid respiration, cyanosis, tachycardia and low-grade fever. Untreated and mildly treated mineral oils are strongly associated with an increased risk of scrotal and skin cancer but can also cause gastrointestinal, rectal, bladder and certain respiratory-tract cancers.\nConcepts: TRAY, SURGICAL, INSTRUMENT (Device associated with trolleys)\tMineral Oil Oil (Water repellent preparation, NOS)\tundef.alrg sol.narr req'd (Allergens)\tCD25 Negative (Expression Negative)\tNPI1G09 (Intellectual Product)", + "output": "Mineral Oil Oil (Water repellent preparation, NOS)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of transforming growth factor-beta secretion.\nConcepts: cope (Emotional Adjustment)\tnegative regulation of TGFbeta secretion (regulation of transforming growth factor-beta secretion)\tsequestering of sperm (Organ or Tissue Function)\tUnresectable Gastric Carcinoma (Unresectable Digestive System Carcinoma)\tsignal recognition particle, plasma membrane targeting (signal recognition particle location)", + "output": "negative regulation of TGFbeta secretion (regulation of transforming growth factor-beta secretion)" + }, + { + "input": "Definition: something described as a species of Gram-positive, rod shaped, facultatively heterofermentative bacteria in the phylum Firmicutes. This species is nonmotile and non spore forming. L. paracasei is a normal flora component of the the human oral cavity and gastrointestinal tract. It may be considered a subspecies of Lactobacillus casei.\nConcepts: splanchnic nerve (Autonomic Pathways)\tThoracic Viscera (Structure of viscus)\tCRBMZPN (CNS Affecting Drug Measurement)\tLactobacillus Paracasei (Lactobacillus)\tSmooth muscle (tissue) (Skeletal and/or smooth muscle structure)", + "output": "Lactobacillus Paracasei (Lactobacillus)" + }, + { + "input": "Definition: assistive reproductive technique described as removal of whole viable embryos or fetuses from one environment and transplantation into the same or new environment.\nConcepts: beta-cyclopiazonic oxidocyclase activity (oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond)\tMegakaryocyte and Megakaryoblast Morphology Assessment (Hematologic Tests)\tethanolamine oxidase activity (Molecular Function)\tembryo/fetus transplantation (Laboratory Procedure)\tGenus Ralstonia (Alcaligenes)", + "output": "embryo/fetus transplantation (Laboratory Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the integumentary covering of the back.\nConcepts: Skin of back, NOS (Back structure, including back of neck)\tEbs-Pa (Epidermolysis Bullosa Simplex)\tOffice Buildings, Medical (Manufactured Object)\tCullin-4A (Biologically Active Substance)\tradiation dosage (Radiation)", + "output": "Skin of back, NOS (Back structure, including back of neck)" + }, + { + "input": "Definition: Colorectal Adenomatous Polyp described as an autosomal dominant condition caused by mutation(s) in the POLE and/or POLD1 genes, encoding DNA polymerase epsilon catalytic subunit A and DNA polymerase delta catalytic subunit, respectively. It is characterized by colorectal polyposis and a predisposition to colorectal cancer. Mutation(s) in POLE and/or POLD1 genes have been associated with an increased risk of endometrial cancer, breast and brain tumors, and multi-tumor phenotypes.\nConcepts: Pancreatic Infection (Infection of digestive system)\tMonascus Looss, 1907 (Eurotiales)\tPPAP (Colorectal Adenomatous Polyp)\t3: 49041832-49036767 (Spatial Concept)\ttransition rule (Idea or Concept)", + "output": "PPAP (Colorectal Adenomatous Polyp)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual bruised easily over the last seven days.\nConcepts: Laminar Air Flow Units, Fixed, Surgical (Medical Device)\tA1 adenosine receptor binding (adenosine receptor binding)\tDid you bruise easily (Intellectual Product)\topen to enrollment (Finding)\tradiation therapy care (rnrx medication)", + "output": "Did you bruise easily (Intellectual Product)" + }, + { + "input": "Definition: Substance Abuse Detection described as a measurement of the halazepam present in a biological specimen.\nConcepts: positive regulation of torso signaling pathway (Molecular Function)\tSurgery for Rheumatic Fever (ACC-AHA Measure)\tPancreatic Prohormone (Amino Acid, Peptide, or Protein)\tindole phytoalexin breakdown (phytoalexin catabolic process)\tHLZPM (Benzodiazepines Assay)", + "output": "HLZPM (Benzodiazepines Assay)" + }, + { + "input": "Definition: Medical Device described as an ostomy pouch and accessories is a device that consists of a bag that is attached to the patient's skin by an adhesive material and that is intended for use as a receptacle for collection of fecal material or urine following an ileostomy, colostomy, or ureterostomy (a surgically created opening of the small intestine, large intestine, or the ureter on the surface of the body). This generic type of device and its accessories includes the ostomy pouch, ostomy adhesive, the disposable colostomy appliance, ostomy collector, colostomy pouch, urinary ileostomy bag, urine collecting ureterostomy bag, ostomy drainage bag with adhesive, stomal bag, ostomy protector, and the ostomy size selector, but excludes ostomy pouches which incorporate arsenic-containing compounds.\nConcepts: KRT232 (Organic Chemical)\tCOLLECTOR, OSTOMY (Medical Device)\tNeurotrophic Tyrosine Kinase, Receptor, Type 1 Gene Mutation (NTRK Family Gene Mutation)\tOABQ0124 (Intellectual Product)\tenzyme repression (Genetic Function)", + "output": "COLLECTOR, OSTOMY (Medical Device)" + }, + { + "input": "Definition: Disease or Syndrome described as a rheumatic syndrome of possibly allergic origin, usually affecting children and adolescents, and characterized by high fever, exanthema, arthralgia, leukocytosis, and increased sedimentation rate.\nConcepts: negative regulation of BMP signalling pathway by extracellular matrix sequestering of BMP (Cell Function)\tWisslers Syndrome (Inflammatory disorder)\tCEPP (Regimen Used to Treat Non-Hodgkin Lymphoma)\tacidic nuclear phosphoprotein 32 family member B (Apoptosis Promoter Gene)\tBenign Cellular Infiltrate (Cellular infiltrate)", + "output": "Wisslers Syndrome (Inflammatory disorder)" + }, + { + "input": "Definition: TSCC Questionnaire Question described as trauma Symptom Checklist for Children - Remembering scary things.\nConcepts: Decreased helper T cell proportion (Finding)\tVz Obs by F (Volume of Distribution of Absorbed Fraction)\tTSCC0112 (TSCC Questionnaire Question)\tPlatelet anisocytosis (Blood smear finding)\tVitamin A Measurement (Laboratory Procedure)", + "output": "TSCC0112 (TSCC Questionnaire Question)" + }, + { + "input": "Definition: epithelial cilium movement involved in extracellular fluid movement described as the movement of cilia of epithelial cells of the Left Right Organizer (LRO), also referred to as the node in mouse or the Kupffer's vesicle in zebrafish, resulting in the leftward fluid flow across the LRO and generation or transport of a signal which determines asymmetry in an organism's body plan with respect to the left and right halves.\nConcepts: IP Trial Suppl Mtng Matl (Study Material)\tTest, Acoustic Impedance (Hearing Tests)\tSelective Washing (Diagnostic Procedure)\tcilium movement involved in determinationof L/R asymmetry (Cell Function)\tGeiger-Mueller Counter Tube (Radiology/Radiation Therapy Equipment and Supplies)", + "output": "cilium movement involved in determinationof L/R asymmetry (Cell Function)" + }, + { + "input": "Definition: medical specialty by patient described as aspects of medicine that contribute to or deal with the nature, control and treatment of disease in all species of animals.\nConcepts: Persons, Transgendered (Population Group)\tVeterinary Medicine (Career Areas)\tPenile infection (Finding)\tCHAPTER 6 GENITOURINARY AND REPRODUCTIVE FUNCTIONS (BODY FUNCTIONS)\tAdverseEventActionTakenRelationship (Action Taken with Study Treatment)", + "output": "Veterinary Medicine (Career Areas)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had little interest or pleasure in doing things.\nConcepts: S-adenosyl methionine biosynthesis (Molecular Function)\tFunctions related to pregnancy (Procreation functions)\tLittle interest or pleasure in doing things (Findings-Based Question)\tjaw; alveolitis (Inflammatory disorder of head)\tPlant Shoot (Plant)", + "output": "Little interest or pleasure in doing things (Findings-Based Question)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the prorubricytes in a biological specimen.\nConcepts: DM Mtng Matl (Intellectual Product)\tintracellular calcium activated chloride channel activity (Molecular Function)\tsubcortical nuclei (Entire basal nuclei)\tBasophilic Normoblast (Laboratory Procedure)\tGrade 1 Extrapyramidal disorder (Extrapyramidal Disorder, CTCAE)", + "output": "Basophilic Normoblast (Laboratory Procedure)" + }, + { + "input": "Definition: VERTEBRAL COLUMN: SURGICAL REPAIRS, CLOSURES AND RECONSTRUCTIONS described as operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy.\nConcepts: Golgi vesicle docking with target membrane (vesicle docking)\tJAK pathway signal transduction adaptor activity (Molecular Function)\tInfant Behavioural Assessment and Intervention Programme (Therapeutic or Preventive Procedure)\tsurgically combining multiple spinal bones into one (Fracture Fixation)\tDisperse or dissolve (Functional Concept)", + "output": "surgically combining multiple spinal bones into one (Fracture Fixation)" + }, + { + "input": "Definition: Cell Function described as enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.\nConcepts: Dry Powder Diffusion Mixing (Mix)\tSodium hypochlorite-containing product (Bleach)\tReferenceResult.referenceTypeCode (Intellectual Product)\tCholestasis-pigmentary retinopathy-cleft palate syndrome (Disease or Syndrome)\tobsolete symport (Cell Function)", + "output": "obsolete symport (Cell Function)" + }, + { + "input": "Definition: Transcription factor genes described as this gene plays a role in the positive regulation of transcriptional elongation. It is also involved in the modification of chromatin.\nConcepts: Chief Complaint is Present Monthly (Chief complaint)\tSFMP221 (Intellectual Product)\tConstitutional chronic hypocalcaemia (Endocrine disorders congenital NEC)\tSUPT6H (Transcription factor genes)\tDicloxacillinum (semisynthetic penicillins)", + "output": "SUPT6H (Transcription factor genes)" + }, + { + "input": "Definition: Nucleotide Motifs described as specific sequences in the viral nucleic acid that are involved in packaging the viral genome (VIRAL GENOME PACKAGING) into the VIRUS PARTICLES.\nConcepts: Bacteroides tectus corrig. Love et al. 1986 (Bacteroides)\tTemporary cerebral dysfunction, vascular (cerebral ischemia or hypoxia)\tpg/d (Unit of Dose Calculation)\tVirus Packaging Sequence (Nucleotide Sequence)\tSurgical Glue Delivery Instruments (Medical Device)", + "output": "Virus Packaging Sequence (Nucleotide Sequence)" + }, + { + "input": "Definition: Cell Function described as the process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins.\nConcepts: protein secretion by the type I secretion system (Protein Secretion)\tGS9219 (Purine antagonist)\tHI - Hemagglutination inhib (ObservationMethod - CodeSystem)\tAbnormality of the ocular adnexa (Anatomical Abnormality)\tCocaine Benzoylecgonine Ecgonine (Cocaine measurement)", + "output": "protein secretion by the type I secretion system (Protein Secretion)" + }, + { + "input": "Definition: something described as a fetus with a sonographic estimation of fetal weight below the tenth percentile for a given gestational age, with increasing specificity for adverse perinatal outcomes below the third percentile.\nConcepts: Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes (T-cell Receptor-engineered T-cells)\tIon-Selective Electrolyte Analyzers (Analyzers, Laboratory, Body Fluid, Electrolyte)\tIntrauterine Growth Retardation (Fetal Diseases)\thomoserine O-acetyltransferase activity (O-acetyltransferase activity)\tdoxaminol (Adrenergic beta-Agonists)", + "output": "Intrauterine Growth Retardation (Fetal Diseases)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an iron (non-heme) test system is a device intended to measure iron (non-heme) in serum and plasma. Iron (non-heme) measurements are used in the diagnosis and treatment of diseases such as iron deficiency anemia, hemochromatosis (a disease associated with widespread deposit in the tissues of two iron-containing pigments, hemosiderin and hemofuscin, and characterized by pigmentation of the skin), and chronic renal disease.\nConcepts: TEG (blood coagulation studies)\tMILFASARTAN (Pharmacologic Substance)\tBATHOPHENANTHROLINE, COLORIMETRY, IRON (Indicator, Reagent, or Diagnostic Aid)\tUltrasonic Surgical Units, Dental (Medical Device)\tAdjustable Dose Pre-Filled Drug Pen (Manufactured Object)", + "output": "BATHOPHENANTHROLINE, COLORIMETRY, IRON (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in).\nConcepts: Grade 2 Hyperglycemia, CTCAE (Hyperglycemia, CTCAE)\tnucleobase:cation symporter activity (nucleobase transmembrane transporter activity)\tApheresis platelets (Blood product)\tOrgan cluster (Body Location or Region)\tVCC (Health Care Related Organization)", + "output": "nucleobase:cation symporter activity (nucleobase transmembrane transporter activity)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Early Epileptic, Rett/Atypical Rett described as molecular assay reagents intended to identify deletions and duplications in genes associated with Rett syndrome and atypical Rett syndrome, neurodevelopmental disorders that are most frequently diagnosed in girls, and are associated with a variety of symptoms (e.g., progressive loss of hand movements, progressive deficits in communication) that begin to appear at 6 to 12 months of age. Genetic variants at multiple loci have been associated with Rett syndrome and atypical Rett syndrome. These reagents are intended to detect deletions and duplications in multiple Rett syndrome- and atypical Rett syndrome-associated loci simultaneously.\nConcepts: Rett Syndrome and Atypical Rett Syndrome Gene Deletion/Duplication Reagents (Medical Device)\tBeclin 1, Autophagy Related Gene (Gene or Genome)\tpoly(inosinic acid) poly(cytidylic(12), uridylic)acid (Pharmacologic Substance)\tArachidonate 5 Lipoxygenase Activating Proteins (Membrane Proteins)\tCongenital deformity of digestive system (Other congenital malformations of digestive system)", + "output": "Rett Syndrome and Atypical Rett Syndrome Gene Deletion/Duplication Reagents (Medical Device)" + }, + { + "input": "Definition: Stage 0 Renal Pelvis and Ureter Cancer AJCC v7 described as stage 0is includes: Tis, N0, M0. Tis: Carcinoma in situ. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Stage 0is Renal Pelvis and Ureter Urothelial Carcinoma (Stage 0 Renal Pelvis and Ureter Cancer AJCC v7)\tNLM CUI (Intellectual Product)\tProgressive cavitating leukoencephalopathy (Autosomal recessive hereditary disorder)\tATAXIC GAIT (examination of gait and stance)\tVz Pred for UB (Quantitative Concept)", + "output": "Stage 0is Renal Pelvis and Ureter Urothelial Carcinoma (Stage 0 Renal Pelvis and Ureter Cancer AJCC v7)" + }, + { + "input": "Definition: Delayed Release Dosage Form described as a capsule composed of active and/or inert ingredient(s) small, spherical structures that have been coated with a substance that is designed to impede the immediate release of the active and/or inert ingredient(s) after administration.\nConcepts: Thermoproteus Zillig and Stetter 1982 (Archaeon)\tPenile Cancer cNX TNM Finding v8 (Penile Cancer Clinical Regional Lymph Nodes TNM Finding v8)\tcaffeine oxidase activity (Molecular Function)\tCapsule, delayed release pellets (Delayed Release Capsule Dosage Form)\tTreatment of Neck Affected Participation in Social Activities (Intellectual Product)", + "output": "Capsule, delayed release pellets (Delayed Release Capsule Dosage Form)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene.\nConcepts: Flacourtia (Salicaceae)\teisosome membrane domain/MCC (plasma membrane raft)\tPosterior common hepatic lymph node group (Set of visceral abdominal lymph nodes)\ttoluene 4-monooxygenase activity (Molecular Function)\tCOXEN Score 20 (COXEN Sensitivity Scale)", + "output": "toluene 4-monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3.\nConcepts: Tamil Language (Language)\th.pmol/l/(mg/g) (Measurement Unit Description)\tLeukocytes/Total Cells (Laboratory Procedure)\tN-formimidoyl-L-glutamate iminohydrolase activity (Molecular Function)\tMafG Transcription Factor (Biologically Active Substance)", + "output": "N-formimidoyl-L-glutamate iminohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a mutation that is documented to be associated with risk of disease.\nConcepts: down regulation of dendrite morphogenesis (negative regulation of cell morphogenesis involved in differentiation)\tFAC018-I Am Able to Enjoy Life (Intellectual Product)\tDriver Mutation (Cell or Molecular Dysfunction)\tKIDNEY: EXCISIONS (Procedures on Kidney)\tAmt Rec Infinity Obs Norm by BMI (Amount Recovered Infinity Observed)", + "output": "Driver Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Shellfish toxin described as the biotoxin saxitoxin.\nConcepts: cerebellar granular layer formation (anatomical structure formation involved in morphogenesis)\tCASSETTE, MEASUREMENT, ARDRAN-CROOKS (Medical Device)\tLung Nodule (Finding)\tsaxitoxins (Marine Toxins)\terythroblast (Bone Marrow Cells)", + "output": "saxitoxins (Marine Toxins)" + }, + { + "input": "Definition: negative regulation of biological process described as any process that stops, prevents, or reduces the frequency, rate or extent of fibrinolysis, an ongoing process that solubilizes fibrin, resulting in the removal of small blood clots.\nConcepts: DAD01-Brush Teeth Take Care of Dentures (Intellectual Product)\tNeutrophil Cytoplasmic Ab, Atypical (Immunologic Tests)\tEGFR I789 L792del (Cell or Molecular Dysfunction)\tAzoles (Heterocyclic Compounds, 1-Ring)\tdownregulation of fibrinolysis (regulation of fibrinolysis)", + "output": "downregulation of fibrinolysis (regulation of fibrinolysis)" + }, + { + "input": "Definition: Organism Function described as human behavior or decision related to REPRODUCTION.\nConcepts: Reproductive Behavior (multicellular organismal reproductive process)\tglial tumor (Abnormality of the glial cells)\tGrade 1 Neonatal Hypertension, Adverse Event (Finding)\tEGFR L747 E749del (Cell or Molecular Dysfunction)\tEncircling double aortic arch (Double Aortic Arch)", + "output": "Reproductive Behavior (multicellular organismal reproductive process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as polyubiquitin-C (685 aa, ~77 kDa) is encoded by the human UBC gene. This protein is involved in both the synthesis of ubiquitin monomers and polyubiquitination.\nConcepts: embryo/fetus monitoring (Prenatal Diagnosis technique)\tGrade 2 Irregular Menstruation, CTCAE (Irregular Menstruation, CTCAE)\tmacromolecule (molecular size)\tmouse encephalomyelitis virus (Virus)\tUBC protein, human (Biologically Active Substance)", + "output": "UBC protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: regulation of interleukin-1 production described as any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell.\nConcepts: regulation of interleukin-1 secretion (regulation of interleukin-1 production)\tinformation disclosure (Communication)\tnursing theory (Idea or Concept)\tMeasured intake of energy via gastroenteral route in 24 hours (Nutritional observable)\tAnti-alpha BCMA/Anti-alpha CD3 T-cell Engaging Bispecific Antibody TNB-383B (Antineoplastic Antibody)", + "output": "regulation of interleukin-1 secretion (regulation of interleukin-1 production)" + }, + { + "input": "Definition: something described as this gene is involved in endocytosis and recycling of the plasma membrane.\nConcepts: Grade 3 Cerebrospinal fluid leakage (Finding)\tLeft Lymph Node Dissection not Done (Finding)\tCOB1 (YAP1 gene)\tEHD1 gene (Trafficking Protein Gene)\tIMMUNOGLOBULIN G Fc RECEPTOR I (Receptor Gene)", + "output": "EHD1 gene (Trafficking Protein Gene)" + }, + { + "input": "Definition: Bacterium described as a species of facultatively anaerobic, Gram positive, cocci shaped bacteria in the phylum Firmicutes. This species is positive for catalase, phosphatase and caseinase and negative for coagulase and oxidase. It can ferment arabinose, cellobiose, fructose, galactose, glycerol, maltose, mannitol, mannose, ribose, sucrose, trehalose, turanose, and xylose but not rhamnose or fucose. S. gallinarum is a commensal organism in poultry and goats, where it can cause opportunistic infections, and is rarely a human pathogen.\nConcepts: Performed Medical Condition Result Clinically Significant Indicator (Functional Concept)\tstage II pleural mesothelioma AJCC v7 (Mesothelioma malignant advanced)\tFoods, Snack (Food)\tProduct containing aspirin (Platelet Aggregation Inhibitors)\tStaphylococcus gallinarum (Bacterium)", + "output": "Staphylococcus gallinarum (Bacterium)" + }, + { + "input": "Definition: Congenital anomaly of thorax described as rare congenital anomaly of the great veins with characteristics of absence of the left brachiocephalic vein (or innominate vein), resulting in an anomalous venous vasculature. Patients are usually asymptomatic and the anomaly is typically discovered intraoperatively. An association with persistence of left superior vena cava, permanent levoatrial cardinal vein or anomaly of the inferior vena cava has been reported in some cases.\nConcepts: Negative Elongation Factor B, human (Transcription Regulatory Protein)\tMicroparticle Enzyme Immunoassay (Laboratory Procedure)\tdown-regulation of histone deacetylation (negative regulation of histone modification)\tCongenital absence of brachiocephalic vein (Disorder of blood vessels of thorax)\tStructure of lower extremity, unspecified (Body Part, Organ, or Organ Component)", + "output": "Congenital absence of brachiocephalic vein (Disorder of blood vessels of thorax)" + }, + { + "input": "Definition: permeabilization of host organelle membrane involved in viral entry into host cell described as induction of macropinosome membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with the capsid. Occurs after internalization of the virus in a macropinosome, and results in release of the viral contents from the macropinosome into the host cell cytoplasm.\nConcepts: macropinosomal membrane permeabilization involved in viral entry into host cell (Cell Function)\t16alpha-methyl-9alpha-fluoro-delta1-hydrocortisone (Steroids, Fluorinated)\tgalactaric acid anion transmembrane transporter activity (aldarate transmembrane transporter activity)\tBACS104A (BACS Functional Test Question)\trRNA N-glycosidase activity (RNA glycosylase activity)", + "output": "macropinosomal membrane permeabilization involved in viral entry into host cell (Cell Function)" + }, + { + "input": "Definition: Replication-Associated Process described as the process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.\nConcepts: detection of calcium ion (detection of chemical stimulus)\tType II atherosclerotic lesion (Atherosclerotic lesion)\tShelter facility (Manufactured Object)\tdP/dt Average (Finding)\tReplication Initiation (Genetic Function)", + "output": "Replication Initiation (Genetic Function)" + }, + { + "input": "Definition: something described as human EXTL1 wild-type allele is located in the vicinity of 1p36.1 and is approximately 15 kb in length. This allele, which encodes exostosin-like 1 protein, is involved in the synthesis of the repeating disaccharide region of heparin/heparin sulfate.\nConcepts: EXL1 (Gene or Genome)\tDerived Indicator (Functional Concept)\tINDO (Oxidoreductase Gene)\tMigration (Movement)\tGrade 2 Electrocardiogram QT corrected interval prolonged (Electrocardiogram QT Corrected Interval Prolonged, CTCAE)", + "output": "EXL1 (Gene or Genome)" + }, + { + "input": "Definition: generation of precursor metabolites and energy described as the process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP.\nConcepts: Breast painful (Pain)\tobsolete cell fraction (Biospecimen)\tHeart rate irregular (CARDIAC RHYTHMS AND RATES: GENERAL TERMS)\tADP phosphorylation (ADP metabolic process)\tMicroRNA 98 (MIR98 gene)", + "output": "ADP phosphorylation (ADP metabolic process)" + }, + { + "input": "Definition: Medical Device described as ergometers designed to measure the work (i.e., the amount of force multiplied by the distance over which the force is applied) or rate of work (i.e., power) performed by the muscles while the patient walks or runs on the moving tread of a treadmill (that is usually an integral part of the ergometer) under controlled conditions. Treadmill ergometers measure the work exerted by patients on a controlled treadmill by determining the speed and the ratio of the treadmill's elevation to its length (usually expressed as a percent grade); the workload imposed by the treadmill depends on the patient's weight. Treadmill ergometers are used in tests intended to determine whether patients have cardiovascular or pulmonary diseases; they are frequently used in tests that include use of a stress exercise physiologic monitoring system.\nConcepts: tomuzotuximab (Pharmacologic Substance)\tPackage Type Not Stated (Package Type)\tPULSE OXIMETRY (Oxygen saturation measurement)\tErgometers, Treadmill (Ergometers)\tGrade 1 Infantile Apnea (Infantile Apnea, Adverse Event)", + "output": "Ergometers, Treadmill (Ergometers)" + }, + { + "input": "Definition: Stage IVC Oral Cavity Cancer AJCC v6 and v7 described as stage IVC includes: Any T, Any N, M1. M1: Distant metastasis.\nConcepts: Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 (Adenoid cystic carcinoma of the oral cavity stage IV)\tProduct containing mogamulizumab (Immunologic Factor)\tadults medulloblastoma (Medulloblastoma)\tesophagus cancer, stage III (stage, esophageal cancer)\tFocal aware autonomic seizure with hypoventilation/hyperventilation/altered respiration (Disease or Syndrome)", + "output": "Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 (Adenoid cystic carcinoma of the oral cavity stage IV)" + }, + { + "input": "Definition: Transferase described as an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine to histamine, forming N-methylhistamine, the major metabolite of histamine in man. EC 2.1.1.8.\nConcepts: S-Adenosyl-L-methionine:histamine N-tele-methyltransferase (Amino Acid, Peptide, or Protein)\toligogalacturonide transport (oligosaccharide transport)\tgap junction channel activity involved in atrioventricular node cell-bundle of His cell electrical coupling (Molecular Function)\tJuxtaglomerular apparatus (Renal Tissue)\t5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "S-Adenosyl-L-methionine:histamine N-tele-methyltransferase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable small molecule, with potential antineoplastic activity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C116728\" active clinical trials using this agent.\nConcepts: Stellaria (Alsineae)\tpai-1 (Plasminogen Inactivators)\tASP9853 (Organic Chemical)\tNeural Development (Cell Differentiation process)\tdown-regulation of establishment of protein localisation to telomere (negative regulation of protein localization to chromosome, telomeric region)", + "output": "ASP9853 (Organic Chemical)" + }, + { + "input": "Definition: CPTAC Questions described as a header for a form section about intraoperative blood product administration.\nConcepts: 6: 137582200-137560315 (Spatial Concept)\tMenopause Status not Evaluated (CPTAC Responses)\tContrast aortogram (Arteriography)\tTransferrin Receptor 2 Gene (Receptor Gene)\tIntraoperative Blood Product Administration (CPTAC Questions)", + "output": "Intraoperative Blood Product Administration (CPTAC Questions)" + }, + { + "input": "Definition: TYRP1 gene described as human TYRP1 wild-type allele is located in the vicinity of 9p23 and is approximately 17 kb in length. This allele, which encodes 5,6-dihydroxyindole-2-carboxylic acid oxidase protein, is involved in the regulation of melanin biosynthesis.\nConcepts: 3 alpha Hydroxysteroid Oxidoreductase (Amino Acid, Peptide, or Protein)\tJebsen-Taylor Hand Function Test (diagnostic procedure)\tCysts, Ovarian (Ovarian and fallopian tube cysts and neoplasms)\tnew nfclt 90min (Therapeutic or Preventive Procedure)\tTRP (Gene or Genome)", + "output": "TRP (Gene or Genome)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of concentration equal to grams per milliliter, divided by micrograms per meter squared.\nConcepts: transection (Division)\tSeneca Valley Virus-001 (Oncolytic Viruses)\tg/mL/(ug/m2) (Quantitative Concept)\tTest Result (History and observations)\trecurrent gestational trophoblastic tumor (Recurrent tumor)", + "output": "g/mL/(ug/m2) (Quantitative Concept)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as nerve fibers that pass directly from the flocculonodular lobe of the cerebellar cortex through the inferior cerebellar peduncle to the vestibular nuclei ( Schiebler-1999 ).\nConcepts: Adenocarcinoma with Productive Fibrosis (Primary malignant neoplasm)\tLa RIBONUCLEOPROTEIN DOMAIN FAMILY, MEMBER 3 (Gene or Genome)\tFAC04105 (FKSI-DRS Version 4 Questionnaire Question)\tcerebellovestibular fibers (Body Part, Organ, or Organ Component)\tMarked muscular hypertrophy (MUSCLE SOFT, TISSUE)", + "output": "cerebellovestibular fibers (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Nephrolithiasis described as buildups of minerals that form in the urinary bladder.\nConcepts: Beds, Fixed (Medical Device)\tSupplemental Qualifiers for Subject Status (Intellectual Product)\tBone Screw (Medical Device)\tStone urinary bladder (Urinary Bladder Diseases)\t2-phenylethylamine receptor activity (G protein-coupled amine receptor activity)", + "output": "Stone urinary bladder (Urinary Bladder Diseases)" + }, + { + "input": "Definition: Biologically Active Substance described as an anti-apoptosis protein expressed in lymphoma and cancers of lung, colon, pancreas, prostate and breast; potent inhibitor of some caspases.\nConcepts: cell proliferation involved in heart valve morphogenesis (Cell Function)\tCockcroft-Gault Formula Utilizing Total Body Weight (Quantitative Concept)\tsurvivin antigen (Vaccine Antigen)\tnegative regulation of amide metabolism (negative regulation of nitrogen compound metabolic process)\tallografts (TRANSPLANTATIONS AND TRANSPOSITIONS)", + "output": "survivin antigen (Vaccine Antigen)" + }, + { + "input": "Definition: Foot artery described as one of the terminal branches of the posterior tibial artery that runs along the inside of the foot to supply the muscles of the sole.\nConcepts: D-valine breakdown (D-valine metabolic process)\tBrain natriuretic peptide 32 (N [Preparations])\tOligosaccharide (Dietary Carbohydrates)\tMedial plantar artery (Arteries)\tHordeins (Amino Acid, Peptide, or Protein)", + "output": "Medial plantar artery (Arteries)" + }, + { + "input": "Definition: Duodenal Diseases described as an ulcer that develops in the jejunal mucosa close to the anastomosis site following a gastroenterostomy procedure.\nConcepts: Uterine Corpus Carcinoma pT2 TNM Finding v7 (Uterine Corpus Carcinoma Pathologic Primary Tumor TNM Finding v7)\tUlcer, stomal (Disease or Syndrome)\tskeletal muscle regeneration at neuromuscular junction (skeletal muscle tissue regeneration)\tDiabetic acidosis, NOS (Glucose in blood specimen above reference range)\tNeedle Holders, Orthopedic (Medical Device)", + "output": "Ulcer, stomal (Disease or Syndrome)" + }, + { + "input": "Definition: Immunologic Adjuvants described as substances used in vaccines to enhance the ability of antigens to elicit an immune response.\nConcepts: Burden, Viral (Microbiological Techniques)\tvaccine adjuvant (Immunologic Adjuvants)\tExtremely Low Birth Weight Infant (Light-for-dates without fetal malnutrition)\tPRMT5 inhibitor GSK3326595 (Pharmacologic Substance)\tNipple Tumor (Breast neoplasms unspecified malignancy)", + "output": "vaccine adjuvant (Immunologic Adjuvants)" + }, + { + "input": "Definition: Person in the healthcare environment described as person under a physician's care for a particular disease or condition. NOTE: A subject in a clinical trial is not necessarily a patient, but a patient in a clinical trial is a subject. Although often used interchangeably as a synonym for subject, a healthy volunteer is not a patient. See also human subject, clinical research subject, healthy volunteer, participant.\nConcepts: Planning, Health (Health Care Economics and Organizations)\tPatients (Persons)\tselenocysteine incorporation (translational readthrough)\tFocal cognitive seizure with expressive dysphasia/aphasia (Cognitive seizure)\torganic heteropentacyclic compound formation (organic heteropentacyclic compound metabolic process)", + "output": "Patients (Persons)" + }, + { + "input": "Definition: Aplasia/hypoplasia of the proximal phalanx of the 3rd toe described as abnormal reduction in length of proximal phalanx of third toe.\nConcepts: QLES1-Enjoyed Talking With Co-workers (Q-LES-Q Questionnaire Question)\tShort proximal phalanx of the third toe (Aplasia/hypoplasia of the proximal phalanx of the 3rd toe)\tMMS1-Copy This Design (MMSE Functional Test Question)\tBupivacaine product (Drug allergens)\tCabozantinib s-malate (c-Met Inhibitor)", + "output": "Short proximal phalanx of the third toe (Aplasia/hypoplasia of the proximal phalanx of the 3rd toe)" + }, + { + "input": "Definition: amino acid metabolism described as amino Acid Biosynthesis consists of cellular enzymatic reactions that produce amino acids, organic compounds containing an amino and a carboxyl group and often used in protein synthesis by the formation of peptide bonds during ribosomal translation of mRNA. Several important amino acids, such as the neurotransmitter g-aminobutyric acid, have other functions than protein synthesis.\nConcepts: Common arterial trunk (Great vessel disorders congenital)\tPseudomonas solanacearum (Smith 1896) Smith 1914 (Ralstonia)\tCocksfoot Grass Pollen IgA (Immunoglobulin measurement)\tAcquired Word Blindnesses (Dyslexia)\tcellular amino acid synthesis (amino acid metabolism)", + "output": "cellular amino acid synthesis (amino acid metabolism)" + }, + { + "input": "Definition: something described as a change in the nucleotide sequence of a receptor tyrosine kinase family gene.\nConcepts: negative regulation of B lymphocyte cytokine production (negative regulation of B cell mediated immunity)\tTyrosine Kinase Receptor Family Mutation (Cell or Molecular Dysfunction)\twhite blood cell aggregation (Cell Function)\tAnalog-to-Digital Converters (Medical Device)\tPHILA (Pennsylvania)", + "output": "Tyrosine Kinase Receptor Family Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: termination of signal transduction described as the signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated.\nConcepts: Folate-unresponsive megaloblastic anemia (Disease or Syndrome)\tSTRPSTAT (Qualitative Concept)\tmitotic spindle elongation during anaphase (Cell Function)\ttermination of Roundabout signal transduction (termination of signal transduction)\tIncreased serum renin (ENDOCRINE FEATURES)", + "output": "termination of Roundabout signal transduction (termination of signal transduction)" + }, + { + "input": "Definition: something described as fissure of the face from the mouth to the eye.\nConcepts: Therapy, Recreational (Other rehabilitation therapy)\tPROSOPOSCHISIS (Congenital Abnormality)\tIrregular end part of the middle bone of the pinky finger (Abnormality of the epiphysis of the middle phalanx of the 5th finger)\tCircular Revolving Beds (Nursing procedure)\t(2R)-phospho-3-sulfolactate synthase activity (carbon-sulfur lyase activity)", + "output": "PROSOPOSCHISIS (Congenital Abnormality)" + }, + { + "input": "Definition: Delusional disorder described as a disorder characterized by the presence of one or more nonbizarre delusions that persist for at least 1 month; the delusion(s) are not due to schizophrenia or a mood disorder, and do not impair psychosocial functioning apart from the ramifications of the delusion(s).\nConcepts: SDS01-Family Life/Home Responsibilities (Intellectual Product)\tPyruvate Dehydrogenase Phosphatase (Hydrolase)\tPhotographic image with lips closed (Photographic image record)\tDELUSIONAL DIS (Schizophrenia and other psychotic disorders)\tFAMS0156 (Intellectual Product)", + "output": "DELUSIONAL DIS (Schizophrenia and other psychotic disorders)" + }, + { + "input": "Definition: something described as join together or fuse.\nConcepts: Salsifies, Black (Plant)\tarachidonate 12-lipoxygenase (Gene or Genome)\tStage III Gastric and Omental GIST AJCC v8 (Gastric and Omental Gastrointestinal Stromal Tumor by AJCC v8 Stage)\tCoalesced (Activity)\tCuffs, Pneumatic Tourniquet, Double Bladder, Contoured, Reusable (Medical Device)", + "output": "Coalesced (Activity)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the Quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Borg Scale Rating of Perceived Exertion Score 19 (Intellectual Product)\tMONITOR, BLOOD-GAS, ON-LINE, CARDIOPULMONARY BYPASS (Medical Device)\tvanadium metallicum/vanadium (Homeopathic remedies letter V)\tQLES1TN (CDISC Questionnaire Terminology)\tGrade 1 Adrenal Insufficiency, CTCAE (Finding)", + "output": "QLES1TN (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Aorta described as systemic arterial trunk, each instance of which is the first arterial trunk arising from the arch of some aorta, which behind some right sternoclavicular joint bifurcates into into the trunks of some right common carotid and some right subclavian arteries, with branch distribution to the right side of somehead and neck and to some right upper limb.\nConcepts: Escherichia coli O104 (Escherichia coli)\t4 O beta D Glucopyranosyl D glucopyranose (Disaccharides)\tLBPA metabolism (Molecular Function)\tMicrotubule Proteins (Biopolymers)\tTrunk of brachiocephalic artery (Aorta)", + "output": "Trunk of brachiocephalic artery (Aorta)" + }, + { + "input": "Definition: protein-cofactor linkage described as the formation of a linkage between a protein amino acid and flavin mononucleotide (FMN).\nConcepts: protein-FMN linkage (Molecular Function)\tUDP-D-GlcNAc:O-L-fucosylpeptide 3-beta-N-acetyl-D-glucosaminyltransferase activity (acetylglucosaminyltransferase activity)\tup-regulation of chronic inflammatory response to antigenic stimulus (regulation of chronic inflammatory response to antigenic stimulus)\tProton Pump Interaction (Ion Pump Interaction)\tSupramammillary Nucleus (Body Part, Organ, or Organ Component)", + "output": "protein-FMN linkage (Molecular Function)" + }, + { + "input": "Definition: something described as a question about whether an individual feels or has felt frightened, as if something awful is about to happen.\nConcepts: Nervi Vascularis (Tissue Part)\tI get a sort of frightened feeling as if something awful is about to happen (Intellectual Product)\tWar Prisoner (Population Group)\tFAVN (Bioassay, In Vitro)\tcaring gastric (Health Care Activity)", + "output": "I get a sort of frightened feeling as if something awful is about to happen (Intellectual Product)" + }, + { + "input": "Definition: Polyunsaturated Fatty Acids described as a class of polyunsaturated fatty acids with 18 carbons and 2 double bonds.\nConcepts: octadecadienoic acid (Long chain fatty acid)\ty (Metric Prefix)\tIchthyosiform Erythroderma, Congenital (Erythrokeratoderma)\tpositive regulation of cytotoxic T cell granule exocytosis (positive regulation of T cell mediated cytotoxicity)\tRecombinant Vaccinia-gp100:209-217 (Pharmacologic Substance)", + "output": "octadecadienoic acid (Long chain fatty acid)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2).\nConcepts: N-methyl-3-aminomethylindole N-methyltransferase activity (Molecular Function)\tintraoperative endocrine injury (endocrine disorders intraoperative complication)\tOrthoses, Lower Limb, Knee-Ankle-Foot, Therapeutic, Infant Bowleg, Dynamic Brace (Medical Device)\talpha-1,3-galactosyltransferase-expressing allogeneic lung tumor cell vaccine (Cell)\tcob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity (Molecular Function)", + "output": "cob(II)yrinic acid-a,c-diamide:FMN oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: oncologic disorders described as neoplasms composed of fatty tissue or connective tissue made up of fat cells in a meshwork of areolar tissue. The concept does not refer to neoplasms located in adipose tissue.\nConcepts: Lipomatous Neoplasms (neoplasm of soft tissue of types)\tNnspcfd HCPCS orthot ref cde (Health Care Activity)\tHaematopoietic tissue (Hematopoietic and Lymphoid Tissue)\tModular Medical Facilities, Stationary, Dental (Dental Equipment and Supplies)\tTransfusion History (Medical History)", + "output": "Lipomatous Neoplasms (neoplasm of soft tissue of types)" + }, + { + "input": "Definition: Enzyme described as eukaryotic elongation factor 2 kinase (725 aa, ~82 kDa) is encoded by the human EEF2K gene. This protein is involved in both the negative regulation of protein synthesis and serine/threonine protein phosphorylation.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class I (Medical Device)\tGenetic Sequence Databases (Databases)\tWound drain (Drain device)\teukaryotic elongation factor-2 kinase, human (Protein-Serine-Threonine Kinases)\tRPTOR Protein (Amino Acid, Peptide, or Protein)", + "output": "eukaryotic elongation factor-2 kinase, human (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Adenocarcinoma of large intestine described as a colorectal adenocarcinoma that develops in patients with a history of Crohn disease.\nConcepts: Tissue Perfusion Management (Physiological: Complex)\tCrohn's Disease-Associated Colorectal Adenocarcinoma (Neoplastic Process)\tMedulloblastoma recurrent (Recurrent Malignant Brain Neoplasm)\tGrade 3 Uterine Perforation, CTCAE (Uterine Perforation, CTCAE 5)\tmembrane repolarization during bundle of His cell action potential (Cell Function)", + "output": "Crohn's Disease-Associated Colorectal Adenocarcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Gene or Genome described as human NR1H4 wild-type allele is located in the vicinity of 12q23.1 and is approximately 91 kb in length. This allele, which encodes bile acid receptor protein, plays a role in both the metabolism of bile acids and ligand-dependent transcriptional regulation.\nConcepts: Stippling of the epiphysis of the middle phalanx of the 5th finger (Stippling of the epiphyses of the 5th finger)\tFasciculus occipitofrontalis inferior (Body Part, Organ, or Organ Component)\tjupiter (Geographic Area)\tCytotoxic T Lymphocyte Associated Antigen 4 (CD Antigens)\tBAR (Gene or Genome)", + "output": "BAR (Gene or Genome)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family.\nConcepts: TNFSF11 binding (Molecular Function)\tBDI - Baseline Focal Score (Finding)\tCHRNCTY (CDISC SEND Terminology)\tintralaminar nuclei (Body Part, Organ, or Organ Component)\tKos1 tyrosine kinase, human (Protein Tyrosine Kinase)", + "output": "TNFSF11 binding (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as compressed air monitors designed to measure and display the concentration of carbon monoxide (CO) in breathing air. These monitors consist of CO sensor (e.g., oxide semiconductor) and an electronic unit including a display. Most monitors also include audio and/or visual alarms activated at prefixed CO concentrations (e.g., 10 or 20 ppm).\nConcepts: Carbon monoxide compressed air/gas monitor (Medical Device)\tMalformation of the zygomatic bone (Deformity of facial bone)\tDNA catabolic process (cellular macromolecule catabolic process)\tWD5D4 2 (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tHuman T-Lymphoma Invasion and Metastasis Inducing TIAM1 Protein (Guanine Nucleotide Exchange Factors)", + "output": "Carbon monoxide compressed air/gas monitor (Medical Device)" + }, + { + "input": "Definition: something described as nuclear factor interleukin-3-regulated protein (462 aa, ~51 kDa) is encoded by the human NFIL3 gene. This protein plays a role in the modulation of transcription.\nConcepts: regulation of hemopoietic stem cell differentiation (regulation of stem cell differentiation)\tCephalometric soft tissue plane (Anatomical reference plane)\tanasarca (Duplicate concept)\tE4 Promoter Binding-Protein 4 (Amino Acid, Peptide, or Protein)\tShoveling, Digging, or Spading 5 Minutes Nonstop (Intellectual Product)", + "output": "E4 Promoter Binding-Protein 4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a coded value specifying how often a dose is administered.\nConcepts: Class 1b Uveal Melanoma (Neoplastic Process)\tProtein Transport (Intracellular Transport)\tH2O2 catabolic process (cofactor catabolic process)\therbicide (Pesticides)\tDose Frequency Code (Intellectual Product)", + "output": "Dose Frequency Code (Intellectual Product)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the orchard grass (Dactylis glomerata) pollen IgA in a biological specimen.\nConcepts: DICLOFENAC NA (Cyclooxygenase Inhibitors)\tSECTION 4-3 CONGENITAL ANOMALIES OF THE CARDIOVASCULAR SYSTEM (Congenital Systemic Disorder)\tAVL01069 (Intellectual Product)\tCocksfoot Grass Pollen IgA (Immunoglobulin measurement)\tElectrical Stimulators (Stimulator)", + "output": "Cocksfoot Grass Pollen IgA (Immunoglobulin measurement)" + }, + { + "input": "Definition: something described as a genus of filarial nematodes. Various immature species have been found to infect the eyes or subcutaneous tissue in humans.\nConcepts: Hutchinson-Gilford Disease (Inborn Errors of Metabolism)\tblue mongolian spots (Skin Abnormalities)\tRefuse (Not to be done)\tDirofilaria (Eukaryote)\tReceptors, Interleukin 9 (CD Antigens)", + "output": "Dirofilaria (Eukaryote)" + }, + { + "input": "Definition: Health Personnel described as a specialist in adapting and applying food and nutrient knowledge to the solution of food and nutritional problems, the control of disease, and the promotion of health. Nutritionists perform research, instruct groups and individuals about nutritional requirements, and assist people in developing meal patterns that meet their nutritional needs; (2) A nutritionist is someone who has completed undergraduate and/or graduate training in the discipline of nutrition without necessarily meeting the academic and experience requirements to qualify for the Registered Dietitian designation.\nConcepts: Melanoma of the Skin TNM Finding v8 (Finding)\tSet of sternopericardial ligaments (Fascia)\tNutritionists (Health Personnel)\tDiabetes Therapy (Therapeutic procedure)\tinspection (Governmental or Regulatory Activity)", + "output": "Nutritionists (Health Personnel)" + }, + { + "input": "Definition: Finding described as an indication that an individual used something prior to their baseline visit.\nConcepts: Proto Oncogene Products c sis (Biologically Active Substance)\tContinuous-Flow Analyzers (Analyzers, Laboratory, Clinical Chemistry, Automated)\tUse Before Visit (Finding)\tCommunity Disaster Preparedness (Community health procedure)\tAngelica Sinensis Root (Plant or Plant Part Extract)", + "output": "Use Before Visit (Finding)" + }, + { + "input": "Definition: Breast Cancer Pathologic Primary Tumor TNM Finding v6 described as breast cancer with tumor size more than 5.0 cm in greatest dimension.\nConcepts: pT3 Carcinoma of the Breast v6 (Breast Cancer Pathologic Primary Tumor TNM Finding v7)\tFormerly Used Menopausal Hormone Therapy (Finding)\tFANCD2 Protein (Phosphoproteins)\tOral Strip Dose Form (Biomedical or Dental Material)\tpositive regulation of skeletal myofiber development (positive regulation of cell development)", + "output": "pT3 Carcinoma of the Breast v6 (Breast Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: cellular component assembly described as the assembly and organization of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.\nConcepts: bitter taste perception (Organism Function)\tflagellar axoneme assembly (Molecular Function)\tAssess (Action)\tPleuroperitoneal membrane (Embryo structure)\tCES (Intellectual Product)", + "output": "flagellar axoneme assembly (Molecular Function)" + }, + { + "input": "Definition: Tetralogy of Fallot described as a rare congenital heart malformation with characteristics of tetralogy of Fallot (pulmonary stenosis, overriding aorta, ventricular septal defect and right ventricular hypertrophy), complete absence or rudimentary pulmonary valve that is both stenotic and regurgitant and an absence of the ductus arteriosus. It presents prenatally with cardiomegaly, polyhydramnios, fetal heart failure, hydrops fetalis and fetal demise or postnatally with cyanosis and respiratory failure due to bronchomalacia secondary to bronchial compression from dilated pulmonary arteries. It is frequently associated with 22q11 deletion.\nConcepts: Siewert Type I (Siewert Classification)\tcare perioperative (Physiological: Complex)\tAssociate of Science (Intellectual Product)\tAbsence of pulmonary valve, Fallot tetralogy, absence of ductus arteriosus syndrome (Congenital Abnormality)\tWall of left atrium (Left atrial structure)", + "output": "Absence of pulmonary valve, Fallot tetralogy, absence of ductus arteriosus syndrome (Congenital Abnormality)" + }, + { + "input": "Definition: Genetic Function described as a triplet codon-amino acid adaptor activity that recognizes an AAG codon.\nConcepts: Osteolytic defects of the phalanges of the 4th finger (Anatomical Abnormality)\testablish (General Qualifier)\tcellular cell wall disassembly (cell wall organization)\tAAG codon-amino acid adaptor activity (Genetic Function)\tCD135 Antigen N841X (FLT3 Protein Variant)", + "output": "AAG codon-amino acid adaptor activity (Genetic Function)" + }, + { + "input": "Definition: something described as a uniformly-labeled radioconjugate composed of glutamine, a naturally occurring non-essential amino acid, in which all five carbons are labeled with the isotope 13C, with potential imaging application. Upon administration of uniformly-labeled [13C]glutamine, the glutamine is taken up and metabolized by tumors and the 13C-containing metabolites can be imaged by 13C nuclear magnetic resonance (NMR) spectroscopy. Since tumor cells take up and metabolize glutamine in higher amounts and through different pathways than normal cells, this agent may help assess the metabolic phenotype of the tumor.\nConcepts: glutamine (Organic Chemical)\tmitral valve disease (Mitral valvular disorders)\tup regulation of GTP binding (regulation of GTP binding)\tCryptococcus albidus Var. albidus (Cryptococcus albidus)\tsubpeduncular nucleus (Body Part, Organ, or Organ Component)", + "output": "glutamine (Organic Chemical)" + }, + { + "input": "Definition: something described as a 60 amino acid (6.5 kDa) trefoil factor that contains a single trefoil domain. It is expressed primarily by surface EPITHELIAL CELLS of the GASTRIC MUCOSA, where it associates with MUCIN 5AC.\nConcepts: lung surfactant (Organic Chemical)\tEWSR1/ERG Fusion Protein (Amino Acid, Peptide, or Protein)\tintracellular immature spore (Cell Component)\tTFF1 Peptide (Amino Acid, Peptide, or Protein)\tup regulation of anion transmembrane transport (positive regulation of ion transmembrane transport)", + "output": "TFF1 Peptide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Tooth surface loss described as chemical, biochemical and/or electrochemical actions causing the degradation of the hard tissue of the tooth.\nConcepts: down-regulation of heparan sulfate binding (regulation of heparan sulfate binding)\tConnective and Soft Tissue Cell (Mesenchymal Stem Cells)\tStern's Edema Rating 4 (Intellectual Product)\tBiocorrosion of tooth (Disease or Syndrome)\tMattress Systems, Rotation (Mattress Systems)", + "output": "Biocorrosion of tooth (Disease or Syndrome)" + }, + { + "input": "Definition: Death described as an indication that the subject's death was due to a mishap.\nConcepts: Bodywork (Therapeutic or Preventive Procedure)\tAccidental death, NOS (Death and sudden death)\t8p12 (Chromosome band)\tgrowth hormone receptor signaling pathway via JAK-STAT (Molecular Function)\tOR51B4 wt Allele (OR51B4 gene)", + "output": "Accidental death, NOS (Death and sudden death)" + }, + { + "input": "Definition: frontal lobe described as the rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.\nConcepts: Reticulocytes (Red blood cell test)\tHYPOSPADIA (Genitourinary)\tSerous pericardium proper (Region of serous pericardium)\tLeft side of colon (Region of colon)\tlateral prefrontal cortex (Body Part, Organ, or Organ Component)", + "output": "lateral prefrontal cortex (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as this gene plays a role in both chromatin remodeling and transcriptional regulation.\nConcepts: Forced Choice (Intellectual Product)\tARID-CONTAINING PROTEIN 1B (Transcription Regulation Gene)\tApplication Form (Intellectual Product)\tOrchard Grass Pollen IgG4 (Immunoglobulin measurement)\tLobectomy Patient (Surgery Patient)", + "output": "ARID-CONTAINING PROTEIN 1B (Transcription Regulation Gene)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgery for rectal cancer involving precise removal of an intact mesorectal envelope with tumor-free margins. Associated with local recurrence rates below 5% in clinical trials.\nConcepts: Regular Isophane Insulin (Proteins)\tSevere pain or disturbing body sensations that limit many activities (Clinical or Research Assessment Answer)\tTME (Colon and Rectal Surgery)\tFAMILY CEBIDAE (Cebidae)\tregulation of aplanospore formation (Cell Function)", + "output": "TME (Colon and Rectal Surgery)" + }, + { + "input": "Definition: something described as expression of fusion protein EWSR1-CREB1 resulting from a t(2;22)(q33;q12). It is present in the vast majority of angiomatoid fibrous histiocytoma cases.\nConcepts: l/h (Unit of Volumetric Flow Rate)\tEWSR1-CREB1 Fusion Protein Expression (Cell or Molecular Dysfunction)\tProstatic Pain (Finding)\tMonoterpenes (Terpenes)\tMRCM attribute domain international reference set (Intellectual Product)", + "output": "EWSR1-CREB1 Fusion Protein Expression (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Epithelium described as a thin layer of tissue that covers organs, glands, and other structures within the body.\nConcepts: Heterocyclic Compounds with 4 or More Rings (Heterocyclic Compounds)\tNon-Neoplastic Gonadal Disorder (Gonadal Disorders)\tWith treatment, about how many women diagnosed with early breast cancer will eventually die of breast cancer (Intellectual Product)\tepithelial tissue (General Body Topography)\tEPIC-26 - Losing Control of Stools (Intellectual Product)", + "output": "epithelial tissue (General Body Topography)" + }, + { + "input": "Definition: Ubiquitination Regulation Protein described as any process that modulates the frequency, rate or extent of protein monoubiquitination.\nConcepts: regulation of siderophore biosynthesis (regulation of cofactor metabolic process)\tregulation of protein monoubiquitinylation (Molecular Function)\tsplayed Y-form DNA binding (DNA secondary structure binding)\tTumor of head and neck (Head and Neck Disorder)\tAnalyses, Single-Cell (Laboratory Procedure)", + "output": "regulation of protein monoubiquitinylation (Molecular Function)" + }, + { + "input": "Definition: Chromosome 4 Physical Location described as physical location of CXCL6_Gene\nConcepts: tropinone (psi-tropine-forming) reductase activity (Molecular Function)\tPODCI378 (PODCI Adolescent Self-Reported Version Questionnaire Question)\tUDP-L-arabinose mutase activity (intramolecular transferase activity)\tglycerol-3-phosphate-glucose phosphotransferase activity (Molecular Function)\t4: 75067448-75069512 (Spatial Concept)", + "output": "4: 75067448-75069512 (Spatial Concept)" + }, + { + "input": "Definition: Breast Microcalcification described as a finding of microcalcifications located within tissues without neoplasm.\nConcepts: Endoderm, NOS (Germinal Layer)\tF-box domain binding (Molecular Function)\tMicrocalcifications present in non-neoplastic tissue (Laboratory or Test Result)\tRosa damascena flower oil (Organic Chemical)\tRisk for compromised human dignity (Finding)", + "output": "Microcalcifications present in non-neoplastic tissue (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as the act of increasing (something) in size or volume or quantity or scope.\nConcepts: EWSR1/ATF1 Fusion Protein (Fusion protein)\tdata element identifier (Intellectual Product)\tSutures, Synthetic, Nonabsorbable (Sutures, Synthetic)\tEnlargement - action (Augmentation procedure)\tRFIGGAB (Laboratory Procedure)", + "output": "Enlargement - action (Augmentation procedure)" + }, + { + "input": "Definition: something described as the carbamate agent XMC.\nConcepts: CCL26 (Amino Acid, Peptide, or Protein)\tXMC (Pharmacologic Substance)\tMycosis Fungoides Variant (Indolent Non-Hodgkin Lymphoma)\tBayesian Statistics (Quantitative Concept)\tAgent, Surface Active (Specialty Uses of Chemicals)", + "output": "XMC (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in calcium ion homeostasis.\nConcepts: 6-Methyleneoxytetracycline (M [Preparations])\tterminal descending limb of sylvian fissure (Body Part, Organ, or Organ Component)\tregulation of superoxide release (regulation of superoxide metabolic process)\tCALBINDIN D29K (Ligand Binding Protein Gene)\tBladder Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Finding)", + "output": "CALBINDIN D29K (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: Pharmacologic Substance described as a recombinant chimeric protein with potent antitumor activity. Cintredekin besudotox is composed of interleukin-13 (IL13), a pleiotropic immunoregulatory cytokine, linked to a mutated form of pseudomonas exotoxin A; this agent targets and kills tumor cells that express the IL13 receptor (IL13R).The IL13 moiety attaches to the IL13R on the tumor cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.\nConcepts: Antagonists, Mineralocorticoid (Anti-Adrenal)\tProcedure Kit/Trays, Acupuncture (Medical Device)\tCintredekin Besudotox (Pseudomonas Exotoxin Immunoconjugate)\tSyndrome, Pallister-Hall (Hypothalamic Neoplasms)\tmitochondrial proton-transporting ATP synthase complex assembly (Molecular Function)", + "output": "Cintredekin Besudotox (Pseudomonas Exotoxin Immunoconjugate)" + }, + { + "input": "Definition: Clostridium species q-z described as any bacterial organism that can be assigned to the species Clostridium spiroforme.\nConcepts: TNFSF11 receptor activity (Molecular Function)\tMotrin IB (Branded drug names Mm to Mz)\tClostridium spiroforme Kaneuchi et al. 1979 (Clostridium)\tAHy (Molecular Function)\tupregulation of protein localisation to synapse (Physiologic Function)", + "output": "Clostridium spiroforme Kaneuchi et al. 1979 (Clostridium)" + }, + { + "input": "Definition: Anatomical line described as the upper margin of the cerebral cortex viewed from the side ( Nomina-1983 ).\nConcepts: positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway (Molecular Function)\tSuperior margin of cerebral hemisphere (Body Location or Region)\tBiomechanical compliance (Quantitative Concept)\tIVD Test Reagent/Kits, Serology, Standard, Parasite (IVD Test Reagent/Kits, Serology, Standard)\tprecorrin-3 methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)", + "output": "Superior margin of cerebral hemisphere (Body Location or Region)" + }, + { + "input": "Definition: Neoplastic Process described as stage I gallbladder cancer is divided into stages IA and IB. In stage IA, cancer has spread beyond the innermost (mucosal) layer to the connective tissue or to the muscle layer. In stage IB, cancer has spread beyond the muscle layer to the connective tissue around the muscle.\nConcepts: Rasp, NOS (Reusable Devices)\tTSCC0146 (Intellectual Product)\tStage I Gallbladder Cancer (Gallbladder Cancer by AJCC v6 Stage)\tPROTHEOBROMINE (Pharmacologic Substance)\tF4/80 Antibody Staining Method (Laboratory Procedure)", + "output": "Stage I Gallbladder Cancer (Gallbladder Cancer by AJCC v6 Stage)" + }, + { + "input": "Definition: something described as agenesis of canine tooth.\nConcepts: LIFE THREATENING (Adverse Event by CTCAE v3 Severity Grade)\tNanoparticle Topology (Physical Phenomenon or Property)\tAbsent canines (Abnormality of canine)\tIncreased hepatocellular lipid droplets (Lipid accumulation in hepatocytes)\tUrinary glycosaminoglycan excretion (Abnormality of urine homeostasis)", + "output": "Absent canines (Abnormality of canine)" + }, + { + "input": "Definition: Piscirickettsiaceae described as a genus of bacteria in the family PISCIRICKETTSIACEAE that is an intracellular rickettsial-like pathogen of FISHES, especially species in the family SALMONIDAE.\nConcepts: Government Funding Type Code (Funding Type Code)\tpositive regulation of primary miRNA processing (regulation of primary miRNA processing)\tEncephalography - general NOS (Echoencephalography)\tPiscirickettsia Fryer et al. 1992 (Piscirickettsiaceae)\tCarbohydrate Antigen 19-9 Measurement (Tumor marker measurement)", + "output": "Piscirickettsia Fryer et al. 1992 (Piscirickettsiaceae)" + }, + { + "input": "Definition: something described as centrifuge through a gradient until a substance reaches equilibrium\nConcepts: serum uric acid level (Intravascular Uric Acid Test)\tpyloric antrum (Zone of stomach)\tEquilibrium Centrifugation (Centrifugation)\tantidepressants maprotiline hydrochloride (Tricyclic Antidepressive Agents)\tribitol phosphate metabolic process (pentitol phosphate metabolic process)", + "output": "Equilibrium Centrifugation (Centrifugation)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of translation initiation, as a result of deprivation of nourishment.\nConcepts: Anti-CD22-CAR m971-BBz Cells (Chimeric Antigen Receptor T-cells)\tdermoid cyst of neck (Germ cell tumor)\tpositive regulation of translational initiation in response to starvation (regulation of translational initiation in response to starvation)\tRefrigerators, Morgue, Walk-In (Medical Device)\tup regulation of tetrapyrrole formation (positive regulation of tetrapyrrole metabolic process)", + "output": "positive regulation of translational initiation in response to starvation (regulation of translational initiation in response to starvation)" + }, + { + "input": "Definition: something described as the packaging of eukaryotic DNA into nucleosomes inhibits the access of factors to DNA and results in the repression of transcription, replication, and recombination. Local modification of histones on enhancers and promoters is required to activate gene expression. The transcription factors that bind to nucleosome-free regions of DNA or to DNA within nucleosomes recruit two types of enzymatic activities that modify the surrounding chromatin architecture. Chromatin remodeling machines, such as SWI/SNF complex, alter the structure of the pronucleosome in an ATP-dependent manner, and often cause nucleosome sliding. The second type of chromatin modifying complexes recruited by transcription factors covalently modify the N-terminal tails of histones by adding or removing phosphate, methyl, or acetyl groups. Virus-induced transcription of the human interferon-beta gene illustrates one of the best-characterized examples of the mechanisms by which the information contained in the DNA is transferred to the histone-N termini by generating novel adhesive surfaces required for the recruitment of transcription complexes. Upon virus infection, the gene is switched on by three transcription factors (NF-kB, IRFs, and ATF-2/c-Jun), and an architectural protein (HMG I(Y)), all of which bind cooperatively to the nucleosome-free enhancer DNA to form an enhanceosome. The enhanceosome targets the modification and repositioning of a nucleosome that blocks the formation of a transcriptional preinitiation complex on the IFN-beta promoter. This is accomplished by the ordered recruitment of HATs, SWI/SNF, and basal transcription factors. Initially, the PCAF HAT-containing complex is recruited, and it acetylates the nucleosome. This is followed by the recruitment of the CBP-PolII holoenzyme complex. The bromodomain containing transcription complexes SWI/SNF and TFIID are recruited to the promoter via bivalent interactions between the enhanceosome and specifically acetylated histone N termini. More specifically, acetylation of H4 lysine 8 is required for recruitment of the SWI/SNF complex, whereas acetylation of lysines 9 and 14 in histone H3 is critical for the recruitment of the general transcription factor TFIID. An unknown kinase recruited by the enhanceosome phosphorylates H3 Ser 10, a prerequisite for H3K14 acetylation by PCAF. The SWI/SNF remodeling machine arrives at the promoter via bivalent interactions with CBP and the acetylated histone N tails. SWI/SNF alters the structure of the nucleosome, thus allowing recruitment and DNA binding of TFIID to the TATA box. The DNA bending induced upon TFIID binding to the promoter causes sliding of the SWI/SNF-modified nucleosome to a new position 36 bp downstream, thus allowing the initiation of transcription. This cascade is obligatory for IFN-beta gene activation.\nConcepts: Mismatch repair endonuclease PMS2 (Biologically Active Substance)\tN-acyltransferase activity (Molecular Function)\tMagnesium Hydroxide/Aluminum Hydroxide/Simethicone Suspension (Antacids)\tCHSF202 (CHART-SF Paper Version Questionnaire Question)\tIFN-Beta Enhancer Pathway (Genetic Function)", + "output": "IFN-Beta Enhancer Pathway (Genetic Function)" + }, + { + "input": "Definition: Life Stage described as a time period that begins at the beginning of the human embryonic stage and continues until the end of adolescence.\nConcepts: childhood (Age related issues)\tpositive regulation of calcium ion import into sarcoplasmic reticulum (positive regulation of intracellular transport)\tnuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Gene or Genome)\tX-linked dominant chondrodysplasia Chassaing Lacombe type (Chondrodysplasia)\tpositive regulation of protein desumoylation (regulation of protein desumoylation)", + "output": "childhood (Age related issues)" + }, + { + "input": "Definition: hydrolase activity, hydrolyzing O-glycosyl compounds described as catalysis of the reaction: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose + H2O = N-acetyl-D-glucosamine + D-glucosamine.\nConcepts: 2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)\tchionanthus virginica/fringe (Homeopathic remedies letter C)\tnegative regulation of feeding behavior (regulation of feeding behavior)\tAutosomal recessive spastic paraplegia type 60 (Disease or Syndrome)\tSimulators, Training, Surgical, Pelvis (Manufactured Object)", + "output": "2-acetamido-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-D-glucose exo-beta-D-glucosaminidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)" + }, + { + "input": "Definition: something described as a species of filamentous fungi in the phylum Zygomycota characterized by sporangiophores that arise from nodes at the point where the rhizoids are formed. R. oryzae is a causative agent of mucormycosis in immunocompromised individuals. This species is used in the fermentation of tempeh.\nConcepts: Rhizopus peka (Rhizopus)\tStage IIIb Penile Cancer (Neoplastic Process)\tVon Hippel Lindau dependent polycythemia (Congenital Disorders)\tCell Cycle Checkpoints (Cell Function)\tHip Trial Prostheses (Medical Device)", + "output": "Rhizopus peka (Rhizopus)" + }, + { + "input": "Definition: Substance described as a continuous amorphous substance that tends to flow and to conform to the outline of its container (i.e., a liquid or a gas). Also used as an adjective to describe something with properties like that of a fluid.\nConcepts: Stereotactic Systems, Image-Guided, Surgical, Orthopedic (Medical Device)\tmitotic spindle elongation (Cell Function)\tfluid (Substance)\tPeptide Syntheses, Synthetic (Activity)\tHave Nausea Feel Pretty Sick (Clinical or Research Assessment Answer)", + "output": "fluid (Substance)" + }, + { + "input": "Definition: Application program software described as software designed to manage/operate computerized information systems intended for healthcare facilities. This software is intended to work with one or a few models of information systems, usually supplied by the same manufacturer. The software performs a variety of algorithms to process the data obtained in specific areas or throughout the facility. Information system software is available as part of the complete information system or as a separate component; the software may be modified (i.e., through the release of modified versions) during the life of the system by releasing updated and/or upgraded versions. Dedicated information software intended for one or more particular applications such as data management, telemedicine, and education is also available.\nConcepts: HHYLTK (Non-Receptor Tyrosine Kinase Gene)\todontoblast (Dental pulp cell)\tSTREPTOCOCCUS ANGINOSUS GROUP (Streptococcus)\tStage II Esophageal Cancer (Esophageal Cancer by AJCC v7 Stage)\tInformation system software (Computer software)", + "output": "Information system software (Computer software)" + }, + { + "input": "Definition: Organ component described as the principal sensory structure of the auditory system, which is located on the basilar membrane in the cochlea.\nConcepts: relapsed adult diffuse mixed cell lymphoma (Neoplastic Process)\tCochlear spiral organ (Organ component)\tFLT3/KIT Kinase Inhibitor AKN-028 (Organic Chemical)\tsubfornical region (Body Location or Region)\tMid L PZpl (Peripheral zone of prostate)", + "output": "Cochlear spiral organ (Organ component)" + }, + { + "input": "Definition: Ligand Binding Protein Gene described as this gene is involved in heparin sulfate binding.\nConcepts: Lipocortin V Gene (Gene or Genome)\tglypican proteoglycan 3 (Gene or Genome)\tEGO-GSE complex location (Cell Component)\tcefotiam HCl (Organic Chemical)\tCaribbean Manatee (Trichechus)", + "output": "glypican proteoglycan 3 (Gene or Genome)" + }, + { + "input": "Definition: PARENT-DDS Questionnaire Question described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) Personal distress: Moderate distress or greater? (mean score > 2).\nConcepts: 17q11-q12 (Cell Component)\tDDS02-Personal Distress: Moderate (PARENT-DDS Questionnaire Question)\tPHQ02-Pain/Problems During Intercourse (Intellectual Product)\tclearance of foreign intracellular RNA (clearance of foreign intracellular nucleic acids)\tEnd-plate irregularities (Finding)", + "output": "DDS02-Personal Distress: Moderate (PARENT-DDS Questionnaire Question)" + }, + { + "input": "Definition: Medical Device described as a continuous ventilator (respirator) is a device intended to mechanically control or assist patient breathing by delivering a predetermined percentage of oxygen in the breathing gas. Adult, pediatric, and neonatal ventilators are included in this generic type of device.\nConcepts: VENTILATOR, CONTINUOUS, MINIMAL VENTILATORY SUPPORT,FACILITY USE (Medical Device)\tFlat distal femoral epiphysis (Anatomical Abnormality)\tWALKER-WARBURG SYNDROME OR MUSCLE-EYE-BRAIN DISEASE, FKTN-RELATED (Disease or Syndrome)\tEQ5D0105 (EQ-5D-3L Questionnaire Question)\tColic [D] (Finding)", + "output": "VENTILATOR, CONTINUOUS, MINIMAL VENTILATORY SUPPORT,FACILITY USE (Medical Device)" + }, + { + "input": "Definition: something described as symptom Impact Questionnaire - Please rate your level of anxiety.\nConcepts: MLL-ABI1 Fusion Protein (Fusion protein)\tPerformed Substance Administration (Performed Clinical Study Activity)\tSIQR - Anxiety (SIQR Questionnaire Question)\tMajor Basic Protein, Eosinophil (Pharmacologic Substance)\tStudy Site Protocol Version Relationship (Relationships)", + "output": "SIQR - Anxiety (SIQR Questionnaire Question)" + }, + { + "input": "Definition: Gastrointestinal Carcinoid Tumor described as a well differentiated neuroendocrine tumor (carcinoid tumor) that arises from the digestive system and is restricted to the site of origin without evidence of metastasis.\nConcepts: Localized Digestive Carcinoid Tumor (stage, gastrointestinal carcinoid tumor)\ttranscription elongation factor complex (protein-containing complex)\t6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone (Antineoplastic Agents)\thandheld computer (Computers)\tWBC count - large unstained cell count (Laboratory Procedure)", + "output": "Localized Digestive Carcinoid Tumor (stage, gastrointestinal carcinoid tumor)" + }, + { + "input": "Definition: Biologically Active Substance described as APOBEC1 complementation factor (594 aa, ~65 kDa) is encoded by the human A1CF gene. This protein is involved in binding to and metabolism of APOB mRNA. Missense mutations in the gene may be associated with melanoma and other neoplastic diseases.\nConcepts: Watch for and Report Your Child's Physical Symptoms and Medical Condition to Medical Team (Intellectual Product)\tEarly Recurrence of Acute Lymphoblastic Leukemia (Early Relapse)\tGrade 1 Stomach Pain, CTCAE (Finding)\tPolyspecific Direct Antiglobulin Test (Laboratory Procedure)\tApo-B RNA Editing Protein (Amino Acid, Peptide, or Protein)", + "output": "Apo-B RNA Editing Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: cardiac neural crest cell delamination described as any cardiac neural crest cell delamination that is involved in outflow tract morphogenesis.\nConcepts: Sacral spinal cord structure (Sacral spine structure)\tcardiac neural crest cell delamination involved in outflow tract morphogenesis (Cell Function)\tHuman Cells, Tissues, and Cellular and Tissue-Based Products Microorganism Testing Only (Laboratory Testing for Bacteria, Virus, or Mycoplasma)\tBurkholderia pickettii (Ralston et al. 1973) Yabuuchi et al. 1993 (Pseudomonas)\tRemoval of thrombus, NOS (Therapeutic or Preventive Procedure)", + "output": "cardiac neural crest cell delamination involved in outflow tract morphogenesis (Cell Function)" + }, + { + "input": "Definition: Follow-up status described as study subjects in COHORT STUDIES whose outcomes are unknown e.g., because they could not or did not wish to attend follow-up visits.\nConcepts: lost to follow-up (Other Finding)\t27-35(27L):MART-1 (Pharmacologic Substance)\tregulation of ribonuclease activity (Molecular Function)\tCochlear Ducts (Subdivision of cochlea)\tFAC084-Part I: Making a Bed Why Not (Intellectual Product)", + "output": "lost to follow-up (Other Finding)" + }, + { + "input": "Definition: something described as adrenocorticotropic hormone (ACTH) deficiency, the cause of which is not present at birth.\nConcepts: Complete duplication of the outermost bone of the pinky toe (Duplication of the distal phalanx of the 5th toe)\tdCMP phosphorylation (Molecular Function)\tthorax and anterior abdomen determination (Organism Function)\tAcquired ACTH Deficiency (Adrenocorticotropic hormone (ACTH) deficiency)\tForkhead in Rhabdomyosarcoma-Like 1 Protein (Amino Acid, Peptide, or Protein)", + "output": "Acquired ACTH Deficiency (Adrenocorticotropic hormone (ACTH) deficiency)" + }, + { + "input": "Definition: Remote location existing client without ICD diagnosis described as assessing the health status of an existing reflexology client in a usual, subsequent, 20-minute, out-of-office meeting to reevaluate and/or develop a treatment plan for reflexology.\nConcepts: Homovanillic acid (Hormone measurement)\tpositive regulation of floral organ abscission (positive regulation of flower development)\tUsual subsequent 20 minutes out-of-office reflexology intake (Remote location existing client without ICD diagnosis)\tPSEUDOMONAS AERUGINOSA, SMALL-COLONY VARIANT (Bacterium)\tNutrition Monitoring (Nutritional Study)", + "output": "Usual subsequent 20 minutes out-of-office reflexology intake (Remote location existing client without ICD diagnosis)" + }, + { + "input": "Definition: medical treatment method described as mandatory term applied to studies dealing with the use of drugs in the clinical treatment of diseases or psychological disorders. Used for human or animal populations. For the use of drugs in non-clinical contexts, use PHARMACOLOGY or PSYCHOPHARMACOLOGY.\nConcepts: AVL0221 (Intellectual Product)\tpharmacotherapies (MedlinePlus Health Topics)\tatrioventricular valve morphogenesis (heart valve morphogenesis)\tVesicular Transport Proteins (Biologically Active Substance)\tADCS-ADL MCI - Perform Pastime, Hobby or Game: Reading (ADCS-ADL MCI Questionnaire Question)", + "output": "pharmacotherapies (MedlinePlus Health Topics)" + }, + { + "input": "Definition: something described as distal bile duct cancer with no regional lymph node metastasis.\nConcepts: Writing Ability (Intellectual Product)\tnon ionizing radiation (Electromagnetic Radiation)\tDistal Bile Duct Cancer pN0 TNM Finding v7 (Distal Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tpteridine-containing compound synthesis (organic cyclic compound biosynthetic process)\tPAINFUL MENSES (Disorder of pelvis)", + "output": "Distal Bile Duct Cancer pN0 TNM Finding v7 (Distal Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: something described as an adverse event for which only minimal, local, or noninvasive intervention (e.g. packing, cautery) is indicated; or that limits instrumental activities of daily living (ADLs, e.g., shopping, laundry, transportation, or ability to conduct finances).\nConcepts: balance exercises (Activity and Exercise Management)\tcholinergic receptor (receptor)\tpositive regulation of tyramine signalling pathway (regulation of tyramine signaling pathway)\t2 (Adverse Event by CTCAE v4 Severity Grade)\tSGRQ0201 (Intellectual Product)", + "output": "2 (Adverse Event by CTCAE v4 Severity Grade)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a calcium test system is a device intended to measure the total calcium level in serum. Calcium measurements are used in the diagnosis and treatment of parathyroid disease, a variety of bone diseases, chronic renal disease and tetany (intermittent muscular contractions or spasms).\nConcepts: METHYLTHYMOL BLUE, CALCIUM (Indicator, Reagent, or Diagnostic Aid)\tScatter Artifact (CT Image Artifact)\tStage IIA Colorectal (Colon or Rectal) Cancer (Stage II Colorectal Cancer AJCC v8)\tupregulation of cholesterol biosynthetic process (regulation of cholesterol biosynthetic process)\tE2F-6 (E2F6 gene)", + "output": "METHYLTHYMOL BLUE, CALCIUM (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report test code.\nConcepts: ascending aorta development (anatomical structure development)\tprotein O-linked glycosylation via tyrosine (Molecular Function)\tPediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report Questionnaire Test Code (Intellectual Product)\tJoubert syndrome with orofaciodigital defect (Familial aplasia of the vermis)\tCuffs, Pneumatic Tourniquet, Single Bladder, Standard, Disposable (Cuffs, Pneumatic Tourniquet, Single Bladder, Standard)", + "output": "Pediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report Questionnaire Test Code (Intellectual Product)" + }, + { + "input": "Definition: something described as a diagnostic spirometer is a device used in pulmonary function testing to measure the volume of gas moving in or out of a patient's lungs.\nConcepts: Diagnostic Spirometers (Pulmonary function analyser/analysis system)\tObservational Studies, Veterinary as Topic (Research Activity)\tEimeriidae (Eukaryote)\tPleistophora species (Fungus)\timmunologic substance development/preparation (technology/technique)", + "output": "Diagnostic Spirometers (Pulmonary function analyser/analysis system)" + }, + { + "input": "Definition: Organic Chemical described as a class of polyunsaturated fatty acids with 16 carbons and 3 double bonds.\nConcepts: Fatty Acid 16:3 (Polyunsaturated Fatty Acids)\tAcetylcholine receptor antibody positivity (Finding)\tIRB-IEC Flnote (Intellectual Product)\tBence Jones Proteinuria (Finding)\tT Cell Immunoglobulin Mucin 3 (Immune Checkpoint Proteins)", + "output": "Fatty Acid 16:3 (Polyunsaturated Fatty Acids)" + }, + { + "input": "Definition: Pharmacologic Substance described as a bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) delta-like protein 3 (DLL3) fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of anti-DLL3/CD3 BiTE antibody AMG 757, this bispecific antibody binds to both the CD3 antigen on cytotoxic T-lymphocytes (CTLs) and the DLL3 antigen found on DLL3-expressing tumor cells. This activates and redirects CTLs to DLL3-expressing tumor cells, which results in the CTL-mediated cell death of DLL3-expressing tumor cells. DLL3, a Notch pathway protein, is overexpressed on a variety of cancer cell types. It plays a key role in embryonic development and in tumor initiation and proliferation.\nConcepts: Anti-DLL3 x Anti-CD3 BiTE AMG 757 (Amino Acid, Peptide, or Protein)\td.mmol/l/(mg/g/d) (Measurement Unit Description)\t13-cis Retinoic Acid (Organic Chemical)\tUBLITUXIMAB (Immunologic Factor)\t9 (Body Location or Region)", + "output": "Anti-DLL3 x Anti-CD3 BiTE AMG 757 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.\nConcepts: arterial stricture (Occlusion of artery)\tPhase Wraparound Artifact (Aliasing Artifact)\tVAGINAL CREAMS FOAMS JELLIES (Feminine Hygiene Products)\t5: 149473128-149413051 (Spatial Concept)\tPKC-gamma (Serine/Threonine Protein Kinase Gene)", + "output": "VAGINAL CREAMS FOAMS JELLIES (Feminine Hygiene Products)" + }, + { + "input": "Definition: Cell Function described as the process in which the mitotic cell cycle is halted during G1 phase, as a result of deprivation of nitrogen.\nConcepts: Increased density of left ventricular trabeculae (Finding)\tanalysis linkage (genetic linkage)\tThyroid Adenomas (Thyroid Gland Follicular Adenoma)\tmitotic G1 cell cycle arrest in response to nitrogen starvation (G1 cell cycle arrest in response to nitrogen starvation)\tCollagen type XI (Biologically Active Substance)", + "output": "mitotic G1 cell cycle arrest in response to nitrogen starvation (G1 cell cycle arrest in response to nitrogen starvation)" + }, + { + "input": "Definition: something described as removal of tissue from the prostate for microscopic examination, using a needle.\nConcepts: Food and Agriculture Organization of the United Nations (Health Care Related Organization)\tMyopathy, Inflammatory (Korean Standard Classification of Disease Version 5)\tSPORES (Governmental or Regulatory Activity)\tLoss of Threshold (Invalid Sensing Medical Device Problem)\tNeedle biopsy of prostate (Puncture biopsy)", + "output": "Needle biopsy of prostate (Puncture biopsy)" + }, + { + "input": "Definition: RPP40 gene described as human RPP40 wild-type allele is located in the vicinity of 6p25.1 and is approximately 9 kb in length. This allele, which encodes ribonuclease P protein subunit p40 protein, plays a role in the generation of tRNA molecules.\nConcepts: Varicella Zoster Virus Screening (Diagnostic Procedure)\tMMS2-Recall Word 3 (Intellectual Product)\tstage IV urethral carcinoma (stage, urethral cancer)\tQuinestrolum (Estrogens and Progestogens)\tRNASEP1 (Gene or Genome)", + "output": "RNASEP1 (Gene or Genome)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report - In the past 7 days, how much of a problem has this been for your child: It is hard for my child to gain or lose weight when he or she wants to.\nConcepts: Impaired Gas Exchange (Pulmonary tissue perfusion status)\tLimb Skeletal System (Body System)\tMaternal Fetal Exchange (Pregnancy)\tPQL1510 (Intellectual Product)\tUndifferentiated Carcinoma of the Extrahepatic Bile Duct (Carcinoma of extrahepatic bile duct)", + "output": "PQL1510 (Intellectual Product)" + }, + { + "input": "Definition: environmental control measures described as particulate air filters designed to remove very fine particulate from the air, typically 99.97% of particles larger than 0.3 micron. These filters usually consist of pleats of filter medium separated by rigid sheets of corrugated paper or aluminum foil; most high efficiency particulate air (HEPA) filters direct the flow of air in a uniform parallel pattern (laminar flow). HEPA filters are used to obtain very low particulate environments in places such as clean rooms, patient isolation chambers, and laminar air hoods; they are also used in high efficiency air cleaners. High-efficiency particulate air filters can remove most aerosolized biological agents and radioactive particles.\nConcepts: positive regulation of release of stored calcium ion (Ca2+) into cytosol (Cell Function)\thepa filters (Medical Device)\t3,4-dihydroxy-1,3,5(10)-estratrien-17-one (Steroidal Estrogen)\tInjectors, Contrast Media, Angiography (Injectors, Contrast Media)\tnmol/L/(ug/m2) (Measurement Unit Description)", + "output": "hepa filters (Medical Device)" + }, + { + "input": "Definition: something described as an orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor RO5424802 binds to and inhibits ALK kinase, which leads to a disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors. Additionally, ALK mutations are associated with acquired resistance to small molecule tyrosine kinase inhibitors.\nConcepts: Submucosal Route of Administration (Parenteral Route of Drug Administration)\tParietal Lobe of the Brain (Body Part, Organ, or Organ Component)\tRO5424802 (ALK Inhibitor)\tbarosma crenulatum/buchu (Organic Chemical)\tMyotonias, Percussion (Finding)", + "output": "RO5424802 (ALK Inhibitor)" + }, + { + "input": "Definition: something described as a species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharynx flora and has a proclivity for abscess formation, most characteristically in the CENTRAL NERVOUS SYSTEM and LIVER.\nConcepts: pseudopapilledema (Examination of optic disc)\tTEETH, PORCELAIN (Medical Device)\tAbnormal circulating metabolite concentration (Finding)\tStreptococcus MG intermedius (Streptococcus milleri Group)\tcycles ovarian (Physiologic Function)", + "output": "Streptococcus MG intermedius (Streptococcus milleri Group)" + }, + { + "input": "Definition: Vesico-Ureteral Reflux described as retrograde flow of urine from the URINARY BLADDER into the URETER. This is often due to incompetence of the vesicoureteral valve leading to ascending bacterial infection into the KIDNEY.\nConcepts: Free Fatty Acid (Fatty acid measurement)\tregurgitation; vesicoureteral (Disorder of ureter)\tSplenic plexus (Autonomic nervous system)\tUnexpected/Unintended Radiation Output (Radiation Output Problem)\tsuppression by symbiont of host programmed cell death (Organism Function)", + "output": "regurgitation; vesicoureteral (Disorder of ureter)" + }, + { + "input": "Definition: Duplicate concept described as cold blooded chordates; larva are usually aquatic, breathing by gills; adults are terrestrial or aquatic, breathing by lungs and through moist glandular skin.\nConcepts: Psychoanalytic interpretation (Psychoanalytic Therapy)\tAMPHIBIANS AND REPTILES (Cold-blooded animal)\tADL03-Pay Items On His/Her Own (Intellectual Product)\tnexine (cellular anatomical entity)\tPLK2 (Serine/Threonine Protein Kinase Gene)", + "output": "AMPHIBIANS AND REPTILES (Cold-blooded animal)" + }, + { + "input": "Definition: Intellectual Product described as a means of identifying and locating an individual device on a communication network. This may include a name based address (e.g., ncicb.nci.nih.gov), or a numeric internet protocol address.\nConcepts: Violet, Gentian (Triphenylmethane azo disinfectant dye)\tIP Address (Telecommunication Address)\tNY-ESO-1-specific TCR Gene-transduced T Lymphocytes (T-cell Receptor-engineered T-cells)\tInterleukin 28A Gene (IFNL2 gene)\thistone mRNA metabolism (mRNA metabolic process)", + "output": "IP Address (Telecommunication Address)" + }, + { + "input": "Definition: Psychotherapy Therapeutic Techniques described as mind-body technique involving the deliberate prompting of mental images, used in the treatment of mental disorders, for performance enhancement, and in helping patients cope with diseases and their symptoms.\nConcepts: Chisels, Orthopedic (Chisel, device)\tIvory Coast (Africa, Western)\tMicrogram/cm2 (Unit of Dose Calculation)\tpatent (Publication Formats)\tIMAGERY (Therapeutic or Preventive Procedure)", + "output": "IMAGERY (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Abnormal results function studies peripheral nervous system special senses described as the clinical electro-oculogram (EOG) is an electrophysiological test of function of the outer retina and retinal pigment epithelium (RPE) in which changes in electrical potential across the RPE are recorded during successive periods of dark and light adaptation.\nConcepts: negative regulation of immature T-lymphocyte aggregation (negative regulation of leukocyte cell-cell adhesion)\tdemethylkotanin metabolism (organic cyclic compound metabolic process)\tUrethral Cancer pNX TNM Finding v8 (Urethral Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tElectro-oculogram abnormal (Abnormal visual electrophysiology)\tclavicle bone (Bone structure of clavicle)", + "output": "Electro-oculogram abnormal (Abnormal visual electrophysiology)" + }, + { + "input": "Definition: something described as tissue that occupies the area between the soft palate and upper portion of the epiglottis.\nConcepts: Extract (Dosage Form by Physical Form)\tregulation of interleukin-25 secretion (Cell Function)\tDrug pessary (Solid Dose Form)\tOropharyngeal Tissue (Tissue)\tFAC099TN (Intellectual Product)", + "output": "Oropharyngeal Tissue (Tissue)" + }, + { + "input": "Definition: Pharmacologic Substance described as an inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity. Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation. This may result in decreased tumor cell proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types.\nConcepts: CXCR4 peptide antagonist LY2510924 (Antineoplastic Protein Inhibitor)\tPhantoms, Imaging (Radiological quality assurance device)\tScissors, Surgical, Middle Ear, Ossicular Wire Prosthesis (Medical Device)\tmultikinase inhibitor AT9283 (Protein Kinase Inhibitors)\tPancreatic nodes (Body Part, Organ, or Organ Component)", + "output": "CXCR4 peptide antagonist LY2510924 (Antineoplastic Protein Inhibitor)" + }, + { + "input": "Definition: Neoplastic Process described as a solitary benign neoplasm arising from the fibrous soft tissues. The tumor is characterized by the presence of spindle-shaped fibroblasts.\nConcepts: Did you have difficulty climbing stairs or getting up out of a chair because of weakness in your legs (Clinical or Research Assessment Question)\tSuspension for injection in pre-filled injector (Dosage Form and Package Type)\tMETOPROLOL (Beta blocking agents, selective)\tgenetics manipulation (Molecular Biology Research Technique)\tSolitary Adult Skin Fibroma (Neoplastic Process)", + "output": "Solitary Adult Skin Fibroma (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: endosulfan + O2 + 2 H+ + 2 e- = endosulfan sulfate + H2O.\nConcepts: endosulfan monooxygenase I activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\tdentures (Prosthesis)\tGrade 4 Gastric stenosis (Finding)\tDegranulation (Cell Function)\tSoft Tissue Sarcoma Pathologic TNM Finding v7 (Soft Tissue Sarcoma TNM Finding v7)", + "output": "endosulfan monooxygenase I activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)" + }, + { + "input": "Definition: something described as an intraluminal artery stripper is a device used to perform an endarterectomy (removal of plaque deposits from arterisclerotic arteries.).\nConcepts: STRIPPER, ARTERY, INTRALUMINAL (Medical Device)\tresponse to axon injury (Organism Function)\tTSCYC - Not Playing Because Depressed (Intellectual Product)\tCoexpression Extrapolation (Other Finding)\tPRTH (Thyroid Hormone Receptor Gene)", + "output": "STRIPPER, ARTERY, INTRALUMINAL (Medical Device)" + }, + { + "input": "Definition: Upper Jaw Molar described as the upper right 2nd molar, as defined by the Universal tooth numbering system.\nConcepts: QLES2TC (CDISC Questionnaire Terminology)\tSkin Melanoma pN2a TNM Finding v7 (Finding)\tPermanent upper right 7 tooth (Structure of permanent tooth)\tLymphocyte Predominant Type Hodgkin's Disease (Neoplastic Process)\tFunding Type Code (Code)", + "output": "Permanent upper right 7 tooth (Structure of permanent tooth)" + }, + { + "input": "Definition: something described as cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.\nConcepts: deadenylylation-independent decapping (methylguanosine-cap decapping)\tgyrus orbitalis longitudinalis internus (Structure of orbital gyrus)\tComedones (Localized skin lesion)\tThrombosis (vein) NOS (Non-site specific embolism and thrombosis)\tanchored component of postsynaptic early endosome membrane (intrinsic component of postsynaptic early endosome membrane)", + "output": "deadenylylation-independent decapping (methylguanosine-cap decapping)" + }, + { + "input": "Definition: replication fork arrest described as a replication fork arrest process that contributes to the termination of DNA replication.\nConcepts: Hemoglobin Gamma-A Chain (Amino Acid, Peptide, or Protein)\tmulticenter trial (Clinical Trial [Publication Type])\treplication fork arrest involved in DNA replication termination (replication fork arrest)\tAnalyzers, Laboratory, Milk (Manufactured Object)\tpolynucleotide (Biopolymers)", + "output": "replication fork arrest involved in DNA replication termination (replication fork arrest)" + }, + { + "input": "Definition: something described as a change in the amino acid residue at position 515 in the toll-like receptor 8 protein where asparagine has been replaced by histidine.\nConcepts: tetrahydrofolate metabolic process (folic acid-containing compound metabolic process)\tAutosomal Recessive Infantile Hypercalcemia (Disease or Syndrome)\tToll-Like Receptor 8 N515H (TLR8 Protein Variant)\tregulation of aspartic-type peptidase activity (regulation of peptidase activity)\tAcute Myeloid Leukemia 2 Protein (Amino Acid, Peptide, or Protein)", + "output": "Toll-Like Receptor 8 N515H (TLR8 Protein Variant)" + }, + { + "input": "Definition: something described as terminology relevant to the microbiology test names of the CDISC Study Data Tabulation Model.\nConcepts: Gram per Cage (Unit of Dose Calculation)\tCDISC SDTM Microbiology Test Name Terminology (Intellectual Product)\tSplenectomy (surgery of spleen)\tBacterium colomatti (Bacterium)\tcatecholamine cell groups (Body Part, Organ, or Organ Component)", + "output": "CDISC SDTM Microbiology Test Name Terminology (Intellectual Product)" + }, + { + "input": "Definition: Family Group described as the individual through whom a family with a genetic disorder is ascertained. In males this is called a propositus, and in females it is called a proposita.\nConcepts: Proband (Family Group)\tFAC050-I Am Bothered by Hair Loss (Intellectual Product)\ttaxis to electron acceptor (Cell Function)\turopod membrane (Cell Component)\tConcept model rule strength (Intellectual Product)", + "output": "Proband (Family Group)" + }, + { + "input": "Definition: something described as an orally bioavailable powder formulation of a synthetic phenylretinamide analogue of retinol with potential chemopreventive and antineoplastic activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types, including those of the colon, breast, prostate, and neuroblastoma. Independent of RAR activation, this agent also modulates gene expression that leads to ceramide-induced, caspase-independent programmed cell death (PCD) via effectors such as ganglioside GD3 and reactive oxygen species (ROS). Compared to the capsule form, the powder contains a mixture of wheat flour, fats, and sugar that may contribute to the enhanced bioavailability of fenretinide. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C63482\" active clinical trials using this agent.\nConcepts: Stage I Malignant Melanoma of the Uvea (Neoplastic Process)\tFossa lateralis (Body Space or Junction)\tCENTRAL AMERICAN (Hispanics)\tDeficiencies, Holocarboxylase Synthetase (Propionic acidemia)\tFenretinide Lipid Matrix (Retinoids)", + "output": "Fenretinide Lipid Matrix (Retinoids)" + }, + { + "input": "Definition: LYSOSOME AND ASSOCIATED STRUCTURES. MICROBODY described as an organelle formed by the fusion of an autophagosome with the lysosome, where the contents of the autophagosome are degraded.\nConcepts: Autophagocytic vacuole (Cell Component)\tRoom temperature (Qualitative Concept)\tPhysical Regulation Component (Diagnosis)\tPhotoactivation Unit Bags (Medical Device)\tHN 2 (Antineoplastic Agents)", + "output": "Autophagocytic vacuole (Cell Component)" + }, + { + "input": "Definition: Electrocardiogram: myocardial infarction described as an electrocardiographic finding of an injury in leads corresponding to the anatomic region of the subendocardial layer of the wall of the heart.\nConcepts: beta-pinacene synthase activity (terpene synthase activity)\tPeripheral fixation (Eccentric visual fixation)\tSubendocardial Myocardial Infarction by EKG Finding (Electrocardiogram: myocardial infarction)\tExtracellular Link Domain Containing 1 Gene (Gene or Genome)\tThyroiditis, Subacute Nonsuppurative (Subacute thyroiditis)", + "output": "Subendocardial Myocardial Infarction by EKG Finding (Electrocardiogram: myocardial infarction)" + }, + { + "input": "Definition: Caucasians described as generally applied to English-speaking White populations of non-Hispanic descent.\nConcepts: Foredigit, NOS (Fingers)\tnegative regulation of ATP metabolism (negative regulation of metabolic process)\tanti-Xa activity international unit(s) (Anti-Coagulation Factor Xa Unit)\tDigital rectal exam (Digital palpation)\tanglos (Population Group)", + "output": "anglos (Population Group)" + }, + { + "input": "Definition: Cardiovascular Surgical Procedures described as the collection of blood from a vein, most commonly via needle venipuncture.\nConcepts: Synaptogyrins (Nerve Tissue Proteins)\tEpidemiologists (Miscellaneous Occupation)\tGroup IIIa (Intergroup Rhabdomyosarcoma Clinical Group Extent of Disease)\tParahippocampalis, Gyrus (Limbic lobe)\tphlebotomy procedure (Procedure with a procedure focus)", + "output": "phlebotomy procedure (Procedure with a procedure focus)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) into glycine and acetaldehyde, with acetaldehyde being subsequently converted to acetyl-CoA.\nConcepts: L-threonine breakdown to acetyl-CoA (Molecular Function)\tcytodiagnosis (Diagnostic tests)\tMills (Medical Device)\tICE-LAP6 Gene (CASP9 gene)\tCystinoses, Nephropathic (Cystinosis)", + "output": "L-threonine breakdown to acetyl-CoA (Molecular Function)" + }, + { + "input": "Definition: Transplantation, Autologous described as fecal transplantation that uses a fecal sample provided by the patient before medical treatment began. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/773677\" active clinical trials using this agent.\nConcepts: Isatuximab-containing product (Monoclonal Antibodies)\tEWS/CREB1 Fusion Protein (Fusion protein)\tautologous fecal microbiota transplantation (Transplantation, Autologous)\tEasy Bleeding (Hemorrhage)\tsocial service (Social support)", + "output": "autologous fecal microbiota transplantation (Transplantation, Autologous)" + }, + { + "input": "Definition: Nasal sinus described as a pyramidal-shaped, thin-walled, air-filled cavity located in the maxilla. It is lined by mucus membrane and periosteum (mucoperiosteum) which contains cilia. It is adjacent to the nasal cavity and communicates with the middle meatus of the nose. It is the largest paranasal sinus and is composed of three recesses: alveolar, zygomatic, and infraorbital.\nConcepts: Spring test (Procedure on sacrum)\tAcellular Vaccines (Pharmacologic Substance)\tprimary cerebral lymphoma (Primary cerebral lymphoma)\tAntrum of Highmore (Nasal sinus)\tPatient Satisfaction Questionnaire Short Form (Intellectual Product)", + "output": "Antrum of Highmore (Nasal sinus)" + }, + { + "input": "Definition: Musculoskeletal observable described as 1. Systems for classifying and recording the preferred directions of fascial motion throughout the body. 2. Based on the observations of J. Gordon Zink, DO, FAAO and W. Neidner, DO.\nConcepts: Cooling, Inadequate (Finding)\t13q11-q12 (Chromosome band)\tMSQOL-54 - Health Limit Walking One Block (Intellectual Product)\tFascial Pattern (Observable entity)\tAdamantinoma Of Long Bones (Primary malignant neoplasm)", + "output": "Fascial Pattern (Observable entity)" + }, + { + "input": "Definition: Organic Chemical described as compounds used in food or in food preparation to replace dietary fats. They may be carbohydrate-, protein-, or fat-based. Fat substitutes are usually lower in calories but provide the same texture as fats.\nConcepts: MYOPATHY, SPHEROID BODY (Autosomal dominant hereditary disorder)\tParsnip yellow fleck virus group (Secoviridae)\t14q23 (Chromosome band)\tArtificial Fat (Organic Chemical)\tNuphar Sm., 1809 (Plant)", + "output": "Artificial Fat (Organic Chemical)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of export of iron ions from inside of a cell, across the plasma membrane and into the extracellular region.\nConcepts: negative regulation of iron export across plasma membrane (Cell Function)\tanterior/posterior axon guidance (Axon Guidance)\tThyrotropin Releasing Hormone Receptor (Receptor)\tmyosin-light-chain phosphatase activity (protein phosphatase activity)\tBreast prosthesis, external (Medical Device)", + "output": "negative regulation of iron export across plasma membrane (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Multiple Sclerosis (FAMS) Mobility: I have trouble getting around in public places.\nConcepts: Delirium management (Psychotherapy)\tFAMS - Trouble Getting Around in Public Places (FAMS Questionnaire Question)\tCDFTCDBD (Microbiology procedure)\tnegative regulation of lamellipodium morphogenesis (negative regulation of lamellipodium organization)\tIFI27 (Laboratory Procedure)", + "output": "FAMS - Trouble Getting Around in Public Places (FAMS Questionnaire Question)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual can chew as well as ever.\nConcepts: regulation of phosphate membrane transport (regulation of inorganic anion transmembrane transport)\tCan Chew as Well as Ever (Clinical or Research Assessment Answer)\tWatching (Mental Process)\tTRANSCRIPTION FACTOR GATA4, MODULATOR OF (Transcription factor genes)\tPI3K-delta Inhibitor YY-20394 (Antineoplastic Enzyme Inhibitor)", + "output": "Can Chew as Well as Ever (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Foot described as partial or incomplete displacement of an articulation.\nConcepts: False negative (Test Result)\tChest hemangioma (Neoplastic Process)\tHave Lots of Plans (Clinical or Research Assessment Question)\tWD5D4 5 (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tsubluxation (Joint Subluxations)", + "output": "subluxation (Joint Subluxations)" + }, + { + "input": "Definition: Cell Function described as any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid.\nConcepts: negative regulation of VLDL remodeling (negative regulation of multicellular organismal process)\tCOLORIMETRIC METHOD, LIPOPROTEINS (Medical Device)\terection; failure (Penile Diseases)\tdihydroflavonol 4-reductase activity (Molecular Function)\tAlternative-complement-pathway C3/C5 convertase -RETIRED- (Amino Acid, Peptide, or Protein)", + "output": "negative regulation of VLDL remodeling (negative regulation of multicellular organismal process)" + }, + { + "input": "Definition: something described as a carbohydrate comprised of eleven or more monosaccharides joined by ether bridges (covalent bonds centered by an oxygen).\nConcepts: Polysaccharide (Dietary Carbohydrates)\tMRD Persistence (Disease Response)\tubiquitin specific protease 6 protein, human (Enzyme)\tTaxanes (Organic Chemical)\tnegative regulation of heme formation (negative regulation of cofactor metabolic process)", + "output": "Polysaccharide (Dietary Carbohydrates)" + }, + { + "input": "Definition: Enzyme Gene described as transferase Genes encode enzymes (Transferases) that transfer a group, such as a methyl group or a glycosyl group, from one compound (donor) to another (acceptor).\nConcepts: Transferase Gene (Enzyme Gene)\tNeural Peptide Receptor (Receptor)\t1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl- (Antimalarial [EPC])\tregulation of peripheral B cell anergy (regulation of peripheral tolerance induction)\tDigital array (Molecular Biology Research Technique)", + "output": "Transferase Gene (Enzyme Gene)" + }, + { + "input": "Definition: something described as mayo-Portland Adaptability Inventory-4 - Pre-injury history before and after injury.\nConcepts: PCYT1A wt Allele (PCYT1A gene)\tHemoglobin Fraction Pattern (Hemoglobin measurement)\tMPAI-4 - Law Violations Pre-Injury (MPAI-4 Questionnaire Question)\t2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol (Pharmacologic Substance)\tHND (Central America)", + "output": "MPAI-4 - Law Violations Pre-Injury (MPAI-4 Questionnaire Question)" + }, + { + "input": "Definition: something described as an application of computed tomography that uses different x-ray spectra to acquire two image sets at the same anatomic location. This technique allows for the analysis of energy-dependent changes in the attenuation of different materials and facilitates the differentiation, characterization, isolation, and distinction of the imaged tissue and material.\nConcepts: Dual energy computed tomography (X-Ray Computed Tomography)\tSelf-Reliance Scale (Research or Clinical Assessment Tool)\tCARAPA GUIANENSIS SEED OIL (C [Preparations])\tarylsulfatase (Sulfatases)\tBTC wt Allele (BTC gene)", + "output": "Dual energy computed tomography (X-Ray Computed Tomography)" + }, + { + "input": "Definition: antihemophilic factor, human described as a preparation containing antihemophilic factor obtained from a single unit of plasma.\nConcepts: TONOMETRY (Tonometry)\tLame sickness (Neuromuscular Junction Diseases)\tCryoprecipitated Antihemophilic Factor (Pharmacologic Substance)\tPlasmodium chabaudi (Eukaryote)\tbovine leukemia virus BLV (Deltaretrovirus)", + "output": "Cryoprecipitated Antihemophilic Factor (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as an exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery.\nConcepts: syndecan-syntenin-ALIX complex (Cell Component)\tStage II Paranasal Sinus Cancer AJCC v6 and v7 (Paranasal Sinus Cancer)\tSuperior pubic shear (Somatic dysfunction of pubic bone)\tHybrid Imaging Systems, CT/PET (Medical Device)\ttriacylglycerol metabolism (acylglycerol metabolic process)", + "output": "syndecan-syntenin-ALIX complex (Cell Component)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by the National Multiple Sclerosis Society in 1997, which was based on items derived from the Functional Capacities Assessment developed by the Michigan Commission for the Blind. This questionnaire measures the level of visual function and difficulties with simple visual tasks such as reading and watching television. The questionnaire contains 5 questions which are scored ranging from 0 (not at all difficult) to 3 (could not do due to visual problems).\nConcepts: enterococcal (Streptococcus Lancefield group D)\tAbnormality of the common carotid artery (Abnormal carotid artery morphology)\tStage II Laryngeal Cancer (Laryngeal Cancer by AJCC v6 Stage)\tRFPENDAT (Temporal Concept)\tIVIS (Clinical or Research Assessment Questionnaire)", + "output": "IVIS (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Non-Tumor Cell Derivative Vaccine described as a population of cells derived from adipose tissue with stem cell and wound repair activities. Adipose-derived regenerative cells (ADRC) consists of several cell types, such as adult stem cells, vascular endothelial cells, and vascular smooth muscle cells, among others. These cells contribute to wound repair through a variety of mechanisms by promoting blood vessel growth and blocking apoptosis. In addition, ADRC can differentiate into several tissue types, such as bone, cartilage, fat, skeletal muscle, smooth muscle and cardiac muscle.\nConcepts: Conceptual Part Of (Idea or Concept)\tsaint john's wort (Medicinal Herbs and Plants)\tadrenal gland development (gland development)\tMARCKS wt Allele (MARCKS gene)\tAdipose-Derived Regenerative Cells (Cell)", + "output": "Adipose-Derived Regenerative Cells (Cell)" + }, + { + "input": "Definition: Body System described as a composite structure in the rat central nervous system defined on the basis of connectivity and function ( Functional CNS Model ) by ( Swanson-2004 ). It includes the following structures: alveus, dorsal part of the fornix, fimbria, precommissural fornix, diagonal band, postcommissural fornix, commissure of the fornix, perforant path and angular bundle.\nConcepts: PCM1/RET Fusion Protein (Amino Acid, Peptide, or Protein)\tForgiveness (Thesaurus of Psychological Index Terms)\tTFF2 Protein (trefoil factor)\techocardiographs (Medical Device)\tfornix system (cerebrum related medial forebrain bundle system)", + "output": "fornix system (cerebrum related medial forebrain bundle system)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a cluster of large cholinergic neurons that form the rostrolateral part of the basal nucleus in the human and the chimpanzee. It is located deep to the putamen next to the temporal limb of the anterior commissure. In the human the anterior and intermediate parts of the nucleus are densely packed. The cells are fewer and more dispersed in the chimpanzee. The nucleus is not present in the macaque or other Old World and New World monkeys. \\r\\nAs part of the basal nucleus it is thought to play a role in attention, learning, memory, and cortical plasticity ( Raghanti-2011 ). In the human it is more prominent in the left hemisphere than the right, and it sends a projection to the inferior frontal gyrus, which includes Broca's area. Those features suggest that the subputaminal nucleus may play a role in speech and cognition ( Simic-1999 ).\nConcepts: Chlorobenzenes (Hazardous or Poisonous Substance)\tSpN (Body Part, Organ, or Organ Component)\tUPD146 (Intellectual Product)\tRecurrent Askin Tumor (Neoplastic Process)\tGrade 2 Oculomotor Nerve Disorder, CTCAE (Oculomotor Nerve Disorder, CTCAE)", + "output": "SpN (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of nuclear migration along microtubule.\nConcepts: ORCHIECTOMY INGUINAL (Therapeutic or Preventive Procedure)\tNon-Neoplastic Oral Cavity Disorder (Non-Neoplastic Oral Disorder)\tdown-regulation of nuclear migration along microtubule (negative regulation of intracellular transport)\tMajor Sperm Fibrous Sheath Protein Positive (Laboratory or Test Result)\tCirculating Proteasome (Cell Component)", + "output": "down-regulation of nuclear migration along microtubule (negative regulation of intracellular transport)" + }, + { + "input": "Definition: something described as nuclear pore complex protein Nup107 (925 aa, ~106 kDa) is encoded by the human NUP107 gene. This protein is involved in nuclear pore assembly.\nConcepts: 9: 34652689-34651894 (Spatial Concept)\tCSS0112 (Intellectual Product)\t107 kDa Nucleoporin (Amino Acid, Peptide, or Protein)\tpositive regulation by symbiont of host G protein-coupled receptor signal transduction (induction by symbiont of host transmembrane receptor-mediated signal transduction)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs cM1 TNM Finding v8 (Finding)", + "output": "107 kDa Nucleoporin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: PHQ-9 Questionnaire Question described as patient Health Questionnaire - 9 - Trouble falling or staying asleep, or sleeping too much.\nConcepts: Ebola virus disease not suspected (Clinical finding not suspected)\tup-regulation of translational elongation (positive regulation of protein biosynthesis)\tAmoebic Liver Abscess (Infection of digestive system)\tPHQ01-Trouble Falling or Staying Asleep (Intellectual Product)\tPedsQL Neuromuscular Module Version 3.0 Teen Report - Hard to Go Places With Equipment (PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question)", + "output": "PHQ01-Trouble Falling or Staying Asleep (Intellectual Product)" + }, + { + "input": "Definition: something described as clinical or physiological indicators that precede the onset of disease.\nConcepts: LOrG (Body Part, Organ, or Organ Component)\tCharacteristic, Prodromal (Diagnosis)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Drain on Financial Resources (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tYttrium Y 90 DOTA Anti-CEA Monoclonal Antibody cT84.66 (Immunologic Factor)\tDefibrillator/Monitors, Line-Powered (Manual external defibrillator)", + "output": "Characteristic, Prodromal (Diagnosis)" + }, + { + "input": "Definition: Cell described as human autologous peripheral blood lymphocytes (PBLs) transduced with a retroviral vector encoding both alpha and beta chains of a murine T-cell receptor (mTCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous anti-NY-ESO-1 mTCR retroviral vector transduced PBLs bind to NY-ESO-1 expressed on tumor cells. This may result in cytotoxic T-lymphocyte (CTL)-mediated killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types.\nConcepts: 22q11.21 (Chromosome band)\tGlyphosine (Organic Chemical)\tResectoscopes (Medical Device)\tNY-ESO-1-Specific mTCR Retroviral Vector Transduced Autologous PBLs (Cell)\tObstruction gastric (Disease or Syndrome)", + "output": "NY-ESO-1-Specific mTCR Retroviral Vector Transduced Autologous PBLs (Cell)" + }, + { + "input": "Definition: something described as a cardiopulmonary resuscitation board is a device consisting of a rigid board which is placed under a patient to act as a support during cardiopulmonary resuscitation.\nConcepts: heme import into cell (Cell Function)\tPhorbolin 1-Related Protein (Hydrolase)\tBoards, Cardiac Resuscitation (Boards)\tHepatitis C Viral Load PCR Measurement (Polymerase Chain Reaction)\tFACT-HEP Version 4 - I Have Nausea (Intellectual Product)", + "output": "Boards, Cardiac Resuscitation (Boards)" + }, + { + "input": "Definition: neuron development described as the process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron.\nConcepts: Abnormal morphology of right ventricular trabeculae (Anatomical Abnormality)\tAluminum Hydroxide-Magnesium Hydroxide (ALUMINUM CONTAINING ANTACIDS)\tZn-DPTA - Pentetate zinc trisodium (Pentetic acid and pentetic acid derivative)\tperipheral nervous system neuron development (Cell Function)\tColumns, Service, Prefabricated (Medical Device)", + "output": "peripheral nervous system neuron development (Cell Function)" + }, + { + "input": "Definition: Research Activity described as a term allowing the classification of the experiment based on the overall experimental design. EXAMPLE(S): factorial designs, covariance designs, blocking designs, titration study OTHER NAME(S): NOTE(S):\nConcepts: ANTIGENS CD 116 (Receptor)\tRisk for electrolyte imbalance (Hydration)\tApoptotic Cysteine Protease MCH2 (caspase)\tExperiment.designType (Research Activity)\tMelanoma- associated delayed early response protein, human (Amino Acid, Peptide, or Protein)", + "output": "Experiment.designType (Research Activity)" + }, + { + "input": "Definition: something described as breast Neoplasm, Miscellaneous is an NCI Cancer Therapeutic Evaluation Program (CTEP) Simplified Disease Classification (SDC) category used to organize cancer-related disease coding that harmonizes with and supports reporting based on the global standard Medical Dictionary for Drug Regulatory Reporting (MedDRA) terminology.\nConcepts: Accidental Vehicle Fire Smoke Exposure (Finding)\tBeing So Restless it is Hard to Sit Still (Findings-Based Question)\tNCI CTEP SDC Breast Neoplasm, Miscellaneous Sub-Category Terminology (Intellectual Product)\tCytoband Range (Microanatomic Structure)\tocellus pigment metabolic process (Secondary Metabolism)", + "output": "NCI CTEP SDC Breast Neoplasm, Miscellaneous Sub-Category Terminology (Intellectual Product)" + }, + { + "input": "Definition: Finding described as a finding that generally has features of degeneration and regeneration.\nConcepts: SDTM-LSNCMPX (Intellectual Product)\tRegeneration/Degeneration (Other Finding)\tmetaplasia (Physical shape)\tChromosomes, Human, Pair 14 (Chromosomes, Human, 13-15)\tDid food and drink taste different from usual (Clinical or Research Assessment Question)", + "output": "Regeneration/Degeneration (Other Finding)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of CXC chemokine receptor 4 (CXCR4) with receptor binding and hematopoietic stem cell-mobilization activities. Burixafor binds to the chemokine receptor CXCR4, thereby preventing the binding of stromal derived factor-1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation; this may induce the mobilization of hematopoietic stem and progenitor cells from the bone marrow into blood. CXCR4, a chemokine receptor belonging to the G protein-coupled receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; CXCL12/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.\nConcepts: International Myeloma Working Group (Working Group)\tastrocytoma, adult infiltrating (Neoplastic Process)\tBurixafor (Organic Chemical)\tACTH RECEPT (Amino Acid, Peptide, or Protein)\tMollica-Pavone-Anterer syndrome (Disease or Syndrome)", + "output": "Burixafor (Organic Chemical)" + }, + { + "input": "Definition: Organ or Tissue Function described as with a high concentration of estrogen receptors, the uterus is one of the most sensitive tissues to the hormone and demonstrates two basic responses to estrogen: it swells by influx of water into the lumen of the uterus, and it increases in weight by the growth of the endometrial layer.\nConcepts: FAC017-I Bruise Easily (Intellectual Product)\tUterine Swelling (Tissue Growth)\tColorectal Neuroendocrine Tumor pT1 TNM Finding v8 (Finding)\timmunocompetence (IMMUNE SYSTEM: GENERAL TERMS)\tAnaplastic pleomorphic xanthoastrocytoma (Astrocytoma)", + "output": "Uterine Swelling (Tissue Growth)" + }, + { + "input": "Definition: Archaeon described as a family of anaerobic METHANOCOCCALES whose organisms are thermophilic methanogens that produce methane from hydrogen and simple carbon sources such as carbon dioxide.\nConcepts: International Classification of Diseases, Ninth Revision, Clinical Modification (International Classification of Diseases)\tANKLE CLONUS (MUSCLE SOFT, TISSUE)\tACUTSTRS (Stressor)\tacetogenins (Fatty Alcohols)\tMethanocaldococcaceae (Methanococcales)", + "output": "Methanocaldococcaceae (Methanococcales)" + }, + { + "input": "Definition: Abnormal cellular physiology described as an abnormality of the cell cycle.\nConcepts: EGFRvIII Peptide (Immunologic Factor)\t4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3 metabolic process (Molecular Function)\tMicrodevice (Medical Device)\tPleura (Pleural sac)\tAbnormality of the cell cycle (Abnormal cellular physiology)", + "output": "Abnormality of the cell cycle (Abnormal cellular physiology)" + }, + { + "input": "Definition: vacuolar transmembrane transport described as the directed movement of basic amino acids out of the vacuole, across the vacuolar membrane.\nConcepts: basic amino acid transmembrane export from vacuole (vacuolar amino acid transmembrane transport)\tPharmacogenomic Test (Molecular Analysis)\tHemoglobin's Chaperone (Homeostasis Regulation Pathway)\tBladder Cancer pMX TNM Finding v6 (Finding)\tWD5-Had to Work at a Lower Level (Intellectual Product)", + "output": "basic amino acid transmembrane export from vacuole (vacuolar amino acid transmembrane transport)" + }, + { + "input": "Definition: postsynaptic specialization membrane described as the membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated.\nConcepts: postsynaptic density membrane (postsynaptic specialization membrane)\tC-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question (Clinical or Research Assessment Question)\tSdFFF (Laboratory Procedure)\tpeptidyl-diphthamide catabolic process (Molecular Function)\tantigen processing and presentation of exogenous peptide antigen via MHC class II (antigen processing and presentation of exogenous peptide antigen)", + "output": "postsynaptic density membrane (postsynaptic specialization membrane)" + }, + { + "input": "Definition: something described as a domain utilized for the submission of subject status records related to persons associated with the study subject.\nConcepts: Associated Persons Subject Status Domain (Associated Persons Domain)\tGenes, Class I (Major histocompatibility complex gene)\tAlpha-type-1 Polarized Dendritic Cells (Non-Tumor Cell Derivative Vaccine)\tregulation of diatomic oxygen metabolic process (regulation of cellular metabolic process)\tGrade 4 Small Intestinal Stenosis, CTCAE (Finding)", + "output": "Associated Persons Subject Status Domain (Associated Persons Domain)" + }, + { + "input": "Definition: Qualitative Concept described as a characteristic or requirement that a subject must meet to participate in a study.\nConcepts: Segmented Neutrophil Count (Laboratory Procedure)\tIndividual attitudes of people in subordinate positions (Individual Behavior)\tATP-Dependent RNA Helicase ROK1-Like (Amino Acid, Peptide, or Protein)\tPerformed Inclusion Criterion (criteria)\tcellular response to IL-11 (cellular response to cytokine stimulus)", + "output": "Performed Inclusion Criterion (criteria)" + }, + { + "input": "Definition: Finding described as mild sore throat; raspy voice\nConcepts: ZO1 (TJP1 gene)\tAcute demyelinating polyneuropathy (Peripheral demyelinating neuropathy)\tNIACR2 (Gene or Genome)\tNM 004333.4:c.1797 1798insACA (Cell or Molecular Dysfunction)\tGrade 1 Laryngeal Inflammation, CTCAE (Finding)", + "output": "Grade 1 Laryngeal Inflammation, CTCAE (Finding)" + }, + { + "input": "Definition: Potency Unit described as a dosing unit equal to the amount of ingredient(s) in a pipe.\nConcepts: {PIPE} (Potency Unit)\tNon-Investigational Product Documentation of Shipment (Document type)\tCell Proliferation-Inducing Gene 54 Protein (Cell Cycle Proteins)\tsequoyitol dehydrogenase activity (Molecular Function)\tGrade 4 Prolapse of Urostomy, CTCAE (Prolapse of Urostomy, CTCAE)", + "output": "{PIPE} (Potency Unit)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as syndecan-1 (310 aa, ~32 kDa) is encoded by the human SDC1 gene. This protein is involved in the mediation of cell adhesion, signaling and cytoskeletal organization.\nConcepts: IDSC1-Appetite (IDS-C Clinical Classification Question)\tSNEEZE (Sneezing)\tKIF23 (Amino Acid, Peptide, or Protein)\tsyndecan-1 protein, human (Immunologic Factor)\tI seldom feel tired or fatigued (Clinical or Research Assessment Answer)", + "output": "syndecan-1 protein, human (Immunologic Factor)" + }, + { + "input": "Definition: something described as a repetitive sequence found in intron 2 of the KDR gene.\nConcepts: Certificates, Death (Certificate)\tIrregular wrist bones (Anatomical Abnormality)\tHypogonadisms, Anosmic (Pituitary Diseases)\tcancer survivor (Survivors)\tKDR Intron 2VNTR (Nucleotide Sequence)", + "output": "KDR Intron 2VNTR (Nucleotide Sequence)" + }, + { + "input": "Definition: stage, adult acute myeloid leukemia described as acute myeloid leukemia in adults which is not growing and responds to treatment. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7936\" active clinical trials using this agent.\nConcepts: SGRQ0151 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tInsulin-Like Somatomedin Peptide I (Amino Acid, Peptide, or Protein)\tZANG (Ethnic group)\tadult leukemia, acute myeloid in remission (Neoplastic Process)\tFECHTNER SYNDROME (Hereditary nephritis)", + "output": "adult leukemia, acute myeloid in remission (Neoplastic Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as activin-binding protein which inhibits the action of activin, and thereby inhibits the release of follicle stimulating hormone.\nConcepts: Class Anthozoa (Eukaryote)\tSTX (Neurotoxins)\tMPAI1-Use of Hands (MPAI-4 Questionnaire Question)\tActivin Binding Protein (Amino Acid, Peptide, or Protein)\tAdverse Event End Time (End Time)", + "output": "Activin Binding Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the process in which sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.\nConcepts: Protein, Oncogene (Amino Acid, Peptide, or Protein)\tLegionella pneumophila IgM Antibody (Immunologic Tests)\tlymphocyte migration into lymphoid organs (Cell Function)\tSCF-Ctf13 ubiquitin ligase complex (SCF ubiquitin ligase complex)\tmitochondrial sulfate transmembrane transport (mitochondrial transmembrane transport)", + "output": "mitochondrial sulfate transmembrane transport (mitochondrial transmembrane transport)" + }, + { + "input": "Definition: Therapeutic Irrigation described as a minimally invasive procedure that permits sampling of peritoneal fluid for cytopathologic analysis.\nConcepts: Toll-Free Telephone Number (Telephone Number)\tPRKG2 wt Allele (Gene or Genome)\tSmall end part of middle finger bone (Small epiphyses of the phalanges of the hand)\tribonuclease IV activity (endoribonuclease activity, producing 5'-phosphomonoesters)\tIrrigation peritoneal cavity (Therapeutic Irrigation)", + "output": "Irrigation peritoneal cavity (Therapeutic Irrigation)" + }, + { + "input": "Definition: Antiviral Therapy described as treatment with drugs that inhibit the ability of the human immunodeficiency virus (HIV) or other types of retroviruses to multiply in the body.\nConcepts: Manipulation of the vertebrae (Procedure on skeletal system)\tHypercupraemia (Finding)\tantiretroviral therapy (Therapeutic or Preventive Procedure)\tEar/Eye Ointment Dosage Form (Ophthalmic Ointment)\tBPX-501 (Cell)", + "output": "antiretroviral therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as air cleaners designed to remove airborne aerosol microorganisms and other biological agent particulates from room air, possibly by applying radiation (e.g., ultraviolet [UV] light). These cleaners typically include a set of fine filters to remove particulates (e.g., 99.97% of particles bigger than 0.3 micron), including airborne particulates (aerosols) with bacteria and other biological agents. Germicidal air cleaners are intended for continuous use in healthcare facilities, including waiting rooms and doctors' offices. Dedicated germicidal air cleaners, which use UV light radiation that can kill most bacteria and many virus types, are also available.\nConcepts: Germicidal Particulate/Gas/Vapor Air Cleaners (Air Cleaners, Particulate/Gas/Vapor)\tIDSC1-Psychomotor Slowing (IDS-C Clinical Classification Question)\tHEAD AND NECK (Upper body part structure)\tHHV7 - Human herpes virus 7 (Virus)\tHealthcare Facility Identifier (Identifier)", + "output": "Germicidal Particulate/Gas/Vapor Air Cleaners (Air Cleaners, Particulate/Gas/Vapor)" + }, + { + "input": "Definition: Phosphoric Monoester Hydrolases described as phospholipid phosphatase 1 (284 aa, ~32 kDa) is encoded by the human PLPP1 gene. This protein plays a role in both the dephosphorylation of phospholipids and regulation of signaling.\nConcepts: Reactive (Therapeutic or Preventive Procedure)\tPAP2a (Phosphoric Monoester Hydrolases)\t10q23.31 (Chromosome band)\tERT - Surprise Responded as Happiness (Intellectual Product)\tBRD4 Interacting Chromatin Remodelling Complex Associated Protein Like (Amino Acid, Peptide, or Protein)", + "output": "PAP2a (Phosphoric Monoester Hydrolases)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.\nConcepts: glutamate receptor binding (signaling receptor binding)\tregulation of floral organ abscission (regulation of flower development)\txian ling gu bao (Pharmacologic Substance)\tOsteosarcoma of Kidney (Extraskeletal Osteosarcoma)\tupregulation of nuclease activity (regulation of nuclease activity)", + "output": "upregulation of nuclease activity (regulation of nuclease activity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the section of the right hepatic duct located in the liver.\nConcepts: morbus down (Mental Retardation)\tMacrofollicular Variant Thyroid Gland Papillary Carcinoma (Papillary thyroid carcinoma)\tDEC-205/NY-ESO-1 fusion protein CDX-1401 (Immunologic Factor)\tIntrahepatic Portion of the Right Hepatic Duct (Intrahepatic bile duct)\tAxial dystonia (Dystonia)", + "output": "Intrahepatic Portion of the Right Hepatic Duct (Intrahepatic bile duct)" + }, + { + "input": "Definition: ubiquitinyl hydrolase activity described as hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein.\nConcepts: Ibotenic acid (Insecticides)\tLys63-specific deubiquitinase activity (ubiquitinyl hydrolase activity)\tRenal Pelvis and Ureter Urothelial Carcinoma Clinical TNM Finding v8 (Finding)\tdiets high protein (Diet)\tupregulation of interleukin-7 biosynthetic process (positive regulation of cytokine biosynthetic process)", + "output": "Lys63-specific deubiquitinase activity (ubiquitinyl hydrolase activity)" + }, + { + "input": "Definition: Peripheral nerve of lower limb described as a branch of the common peroneal nerve. It innervates the ankle and toes.\nConcepts: Granulosa cell (Epithelial Cells)\tDecreased Corpora Lutea (Laboratory test result abnormal)\tJoint Task Force Type 2 Myocardial Infarction (Intellectual Product)\tdeep nerves peroneal (Deep peroneal nerve and its branches)\theart rhythm (Cardiovascular finding)", + "output": "deep nerves peroneal (Deep peroneal nerve and its branches)" + }, + { + "input": "Definition: Foot described as reduction in bone mineral density affecting any or all of the tarsal bones, seven bones of the foot comprising the calcaneus, talus, cuboid, navicular, and the cuneiform bones.\nConcepts: propionyl-CoA dehydrogenase (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tendobrevin-SNAP-25-syntaxin-1a complex (SNARE complex)\tOsteoporotic tarsals (Foot)\tProline-Rich Protein Domains (Amino Acid, Peptide, or Protein)\tMetastatic Ovarian Serous Adenocarcinoma (Ovarian Serous Adenocarcinoma)", + "output": "Osteoporotic tarsals (Foot)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of hypoxia-induced intrinsic apoptotic signaling pathway.\nConcepts: regulation of hypoxia-induced intrinsic apoptotic signaling pathway (Cell Function)\tSurfactant Apoprotein D Deficiency (Surfactant Protein Deficiency)\tStructure of prostatic utricle (Verumontanum)\tC N LIGASES GLN DONOR (Enzyme)\tFACT-P V4 (Clinical or Research Assessment Questionnaire)", + "output": "regulation of hypoxia-induced intrinsic apoptotic signaling pathway (Cell Function)" + }, + { + "input": "Definition: Laboratory Procedure described as an imaging technique that produces spatially resolved images based on the differences in the excited state decay rates of fluorescent compounds in a sample.\nConcepts: upregulation of myeloid dendritic cell cytokine production (positive regulation of dendritic cell cytokine production)\t3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing (Genetic Function)\tFLUORESCENT LIFETIME IMAGING MICROSCOPY (Microscopy, Fluorescence)\tDisagree (Clinical or Research Assessment Answer)\tinterventionGroupQuantity (Quantity)", + "output": "FLUORESCENT LIFETIME IMAGING MICROSCOPY (Microscopy, Fluorescence)" + }, + { + "input": "Definition: Hypertrophic disorder of skin, unspecified described as a form of lichen planus that is characterized by plaques of markedly thickened skin that is often extremely pruritic and localized to the lower legs. It can result in permanent pigmentation and scarring.\nConcepts: Grade 2 Muscle weakness upper limb (Muscle Weakness Upper Limb, CTCAE)\tLichen planus, hypertrophic (Lichen Planus)\tNPI - Anxiety FxS Score (NPI Questionnaire Question)\tLeukocyte-Endothelial Cell Adhesion Molecule 3 (Cell Adhesion Molecules)\tChromicum acidum / chromic acid (Pharmacologic Substance)", + "output": "Lichen planus, hypertrophic (Lichen Planus)" + }, + { + "input": "Definition: A [Preparations] described as 5,7,4'-trihydroxy-flavone, one of the FLAVONES.\nConcepts: 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone (flavone)\tTransforming Immortalized Mammary Gene (ARHGEF5 gene)\tI made the final selection of my treatment after seriously considering my doctor's opinion (Intellectual Product)\tHAQ-DI With VAS - Aids or Devices - Cane (HAQ-DI Questionnaire Question)\tGRANULOSA CELL TUMOR, BENIGN (Rat Genital System Neoplasms)", + "output": "5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone (flavone)" + }, + { + "input": "Definition: Immunologic Factor described as a recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7. Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a number of different cancers. E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes.\nConcepts: Chemotherapy Response Score 2 (Chemotherapy Response Score)\tPonto- (Neuroanatomy)\tAugmentation/Reconstruction Implants, Facial, Cheek (Augmentation/Reconstruction Implants, Facial)\tmttB1 (Molecular Function)\tVERPASEP CALTESPEN (Pharmacologic Substance)", + "output": "VERPASEP CALTESPEN (Pharmacologic Substance)" + }, + { + "input": "Definition: Study Day described as the study day that a macroscopic findings assessment is performed.\nConcepts: Appendiceal Carcinoid Pathologic Primary Tumor TNM Finding v7 (Appendiceal Carcinoid Pathologic TNM Finding v7)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Blastomyces dermatitidis (IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast)\t9: 35722317-35727005 (Spatial Concept)\tStudy Day of Macroscopic Findings (Temporal Concept)\tNursing, Oncologic (Biomedical Occupation or Discipline)", + "output": "Study Day of Macroscopic Findings (Temporal Concept)" + }, + { + "input": "Definition: Immunologic Factor described as a humanized immunoglobulin (Ig) G1 monoclonal antibody against the stem cell factor receptor c-Kit (SCFR; KIT; CD117), with potential antineoplastic and anti-allergic activities. Upon administration, the anti-c-KIT monoclonal antibody CDX 0158 binds to and inhibits the activation of the cell surface antigen c-Kit. This leads to an inhibition of the activation of c-KIT-mediated signal transduction pathways and inhibits cell proliferation in cancer cells expressing c-Kit. In mast cells, inhibition of c-KIT and c-KIT-mediated signaling prevents mast cell activation, degranulation and subsequent cytokine release. c-Kit, a transmembrane protein and receptor tyrosine kinase, is overexpressed in various cell types, including certain cancer cells and mast cells; it plays a key role in the regulation of cell differentiation and proliferation.\nConcepts: maltose transacetylase activity (Molecular Function)\tOrganization Relationship Type Code (Intellectual Product)\tPDDS01TN (Intellectual Product)\tAnti-c-KIT Monoclonal Antibody CDX 0158 (Antineoplastic Antibody)\tLower Extremity Pneumatic Exerciser (Manufactured Object)", + "output": "Anti-c-KIT Monoclonal Antibody CDX 0158 (Antineoplastic Antibody)" + }, + { + "input": "Definition: Leads, Implantable Cardiac Pacemaker described as implantable cardiac pacemaker leads designed to conduct electrical pacing signals from the pulse generating unit of the implantable pacemaker to electrodes placed on the outer surface of the heart (i.e., myocardial) and then conduct the bioelectric cardiac signals back to the unit. These leads typically consist of flexible wires that are completely isolated except at the electrode tip that makes contact with the heart. Myocardial (also known as epicardial) leads are directly attached to the surface of the heart using open surgery; the other end of the leads is attached through a connector to the pulse generator that is usually implanted in a surgical pocket located in the upper chest near the collarbone. Implantable cardiac pacemaker myocardial lead configurations may be unipolar, with one active electrode contact on the heart, or bipolar with two active contacts. Lead size, connector type, and other characteristics of the leads must be compatible with the pulse generator used.\nConcepts: Leads, Implantable Cardiac Pacemaker, Myocardial (Leads, Implantable Cardiac Pacemaker)\tBerardinelli-Seip Congenital Lipodystrophy Type 2 (Congenital Abnormality)\tCardiac valve calcification (Heart)\tDelta-shaped epiphysis of the middle phalanx of the 3rd finger (Triangular epiphyses of the middle phalanges of the hand)\tSMPD1 gene (Gene Mutation)", + "output": "Leads, Implantable Cardiac Pacemaker, Myocardial (Leads, Implantable Cardiac Pacemaker)" + }, + { + "input": "Definition: something described as functional Activities Questionnaire-NACC - Traveling out of the neighborhood, driving, or arranging to take public transportation.\nConcepts: Textile, Apparel, and Furnishings Workers (Professional or Occupational Group)\tPrometazin (Phenothiazine and phenothiazine derivative)\tArthrogryposis multiplex congenita neurogenic type (Joint movement absent)\tHealth Problems Effect on Work Score 0 (Intellectual Product)\tFAQ02-Traveling (Intellectual Product)", + "output": "FAQ02-Traveling (Intellectual Product)" + }, + { + "input": "Definition: Cell Component described as the portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs.\nConcepts: acetylcholine receptor binding activity (signaling receptor binding)\tDefinedActivity.statusCode (Intellectual Product)\tIOUS (Ultrasonography)\tTPMT*3C Allele (TPMT gene)\tcompact myelin (Cell Component)", + "output": "compact myelin (Cell Component)" + }, + { + "input": "Definition: Abnormality of the upper respiratory tract described as an abnormality of the larynx.\nConcepts: Abnormality of the larynx (Abnormality of the upper respiratory tract)\tVisceral peritoneum (Body Part, Organ, or Organ Component)\tmonoterpenoid biosynthetic process (Molecular Function)\tTrue Malignant Histiocytoses (Sarcoma)\tChildhood Visual Pathway Astrocytoma (Astrocytoma of brain)", + "output": "Abnormality of the larynx (Abnormality of the upper respiratory tract)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was unable to see at all.\nConcepts: PCV (TimingEvent - CodeSystem)\tUnable to see at all (Finding)\tDate of First Ever Onset of Angina Pectoris (Date in time)\tHearing Handicap Inventory for Adults, Screening Version (Clinical or Research Assessment Questionnaire)\tCandida antigen immune complex IgG IgM IgA test each test (Laboratory Procedure)", + "output": "Unable to see at all (Finding)" + }, + { + "input": "Definition: Dose form administration method described as drug administration via imbedded implants used as depot formulations to limit high drug concentrations to the area surrounding the pathology or to provide sustained drug release for systemic therapy. Implant systems are used when chronic therapy is indicated and may take the form of highly viscous liquids, semi-solid formulations, rod impregnated with drug substances, or a liquid which gels in situ. Release kinetics may be controlled by varying polymer composition, different types of stimuli, such as electrical, and varying of implant structure, e.g. as coating.\nConcepts: fuchsin acid stain (Indicator, Reagent, or Diagnostic Aid)\tphosphatase regulator activity (Molecular Function)\tImplantation (Functional Concept)\tPODCI309 (Intellectual Product)\tstreptococcus organism (Facultative anaerobic bacteria)", + "output": "Implantation (Functional Concept)" + }, + { + "input": "Definition: something described as human ANP32B wild-type allele is located in the vicinity of 9q22.32 and is approximately 33 kb in length. This allele, which encodes acidic leucine-rich nuclear phosphoprotein 32 family member B, is involved in apoptotic regulation through signal transduction pathways.\nConcepts: PHAPI2 (Gene or Genome)\tkeratin, type I cytoskeletal 19 (Gene or Genome)\tMalformation, Arnold-Chiari (Congenital abnormal fusion)\ttissue inhibitor of metalloproteinase 2, human (Tissue Inhibitor of Metalloproteinases)\tmesomelic dwarfism-small genitalia syndrome (Rare Non-Neoplastic Disorder)", + "output": "PHAPI2 (Gene or Genome)" + }, + { + "input": "Definition: Hematologic Tests described as a measurement of the mean amount of hemoglobin per erythrocyte in a biological specimen, calculated as the product of hemoglobin times ten, divided by the number of erythrocytes.\nConcepts: NCI CTEP Simple Disease Classification Germ Cell Tumors of the CNS Sub-Category Terminology (NCI CTEP SDC CNS Neoplasm (Primary Tumor) Category Terminology)\tUnloadings, Hindlimb (Weightlessness Simulation)\tMean corpuscular haemoglobin (MCH) - NOS (Hematologic Tests)\tUrinary Bladder/Urethra Irrigation/Lavage Procedure Kit/Trays (Procedure Kit/Trays, Irrigation/Lavage)\tGastric Schwannoma (Neoplastic Process)", + "output": "Mean corpuscular haemoglobin (MCH) - NOS (Hematologic Tests)" + }, + { + "input": "Definition: Anti-Arrhythmia Agents described as a calcium channel blocker that is a class IV anti-arrhythmia agent.\nConcepts: Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- (Cardiovascular Agents)\tinhibition of acetylcholine import (inhibition of neurotransmitter uptake)\tregulation of motor neuron apoptosis (Cell Function)\tRANBP2 gene (Gene or Genome)\tzg (Unit of mass)", + "output": "Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- (Cardiovascular Agents)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transcriptional regulation and DNA replication.\nConcepts: Receptors, Presynaptic (Amino Acid, Peptide, or Protein)\tNFIA Gene (Transcription factor genes)\tProduct containing retinol (Organic Chemicals)\tATLAS Clinical Classification Question (Intellectual Product)\tBRDT wt Allele (Gene or Genome)", + "output": "NFIA Gene (Transcription factor genes)" + }, + { + "input": "Definition: Nonclinical Study Design described as the name of a nonclinical study.\nConcepts: HHS (Multiple congenital anomalies)\tcentral tolerance induction to self antigen (central tolerance induction)\tLEC-5 Standard Version - Natural Disaster: Witnessed (LEC-5 Standard Version Questionnaire Question)\tcomorbidities (Finding)\tNonclinical Study Title (Nonclinical Study Design)", + "output": "Nonclinical Study Title (Nonclinical Study Design)" + }, + { + "input": "Definition: something described as an IgG monoclonal antibody against rabies virus glycoprotein with anti-rabies activity. Foravirumab targets rabies virus glycoprotein and prevents both attachment of the virus glycoprotein to host cell surfaces and viral entry. This may prevent rabies infection.\nConcepts: PQL09-Hard to Breathe (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)\tPsychosocial Health Summary Score (Intellectual Product)\tFORAVIRUMAB (Amino Acid, Peptide, or Protein)\tWater, Sea (Saline Waters)\tGiveaway (Idea or Concept)", + "output": "FORAVIRUMAB (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as techniques for the removal of subpopulations of cells (usually residual tumor cells) from the bone marrow ex vivo before it is infused. The purging is achieved by a variety of agents including pharmacologic agents, biophysical agents (laser photoirradiation or radioisotopes) and immunologic agents. Bone marrow purging is used in both autologous and allogeneic BONE MARROW TRANSPLANTATION.\nConcepts: GEM 333 (Pharmacologic Substance)\tadult diffuse small cleaved cell lymphoma, stage III (Adult Diffuse Small Cleaved Cell Lymphoma)\tAVL0211 (Intellectual Product)\tregulation of response to copper ion stress (regulation of response to stress)\tMarrow purging (Tumor Purging)", + "output": "Marrow purging (Tumor Purging)" + }, + { + "input": "Definition: Familial diabetes insipidus described as a rare genetic neurometabolic disease with characteristics of severe intellectual disability, spastic quadriparesis, Leber's congenital amaurosis and diabetes insipidus. Additional manifestations include facial dysmorphy (dolichocephalic skull, hypertelorism, deep-set eyes, hypoplastic nares, low-set ears), short stature, truncal hypotonia and axial hypertonia. Brain anomalies (e.g. thin corpus callosum with lack of isthmus and tapered splenium, hypoplasia or atrophy of the optic chiasm, prominent lateral ventricles, diminished white matter) described on magnetic resonance imaging have been reported. High prenatal alpha fetoprotein and intrauterine growth restriction is observed in routine pregnancy examination.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion, Mitochondrial (Medical Device)\tcadmium ion binding (Molecular Function)\tProduct containing fomepizole (F [Preparations])\tSBIL-2 (Antineoplastic Biological Agent)\tX-linked intellectual disability, limb spasticity, retinal dystrophy, diabetes insipidus syndrome (Spastic tetraparesis)", + "output": "X-linked intellectual disability, limb spasticity, retinal dystrophy, diabetes insipidus syndrome (Spastic tetraparesis)" + }, + { + "input": "Definition: piperazine described as a natural estrogenic substance composed of estrone sulfate and piperazine. Estropipate diffuses through the cell membrane and binds to and subsequently activates the nuclear estrogen receptor found in the reproductive tract, breast, pituitary, hypothalamus, liver, and bone. The activated complex binds to the estrogen response element on the DNA and activates the transcription of genes involved in the functioning of the female reproductive system and secondary sex characteristics.\nConcepts: Abnormal lower cranial nerve function (Pathologic Function)\tPiperazine oestrone sulphate (Pharmacologic Substance)\tChemokine Receptors (Receptors, Cytokine)\tprogressive alteration of chromatin involved in replicative cell aging (progressive alteration of chromatin involved in cell aging)\trebimastat (Matrix Metalloproteinase Inhibitors)", + "output": "Piperazine oestrone sulphate (Pharmacologic Substance)" + }, + { + "input": "Definition: post-embryonic animal morphogenesis described as the process in which the anatomical structures of the anterior cibarial plate are generated and organized.\nConcepts: EOR01-Did You Feel Depressed (Intellectual Product)\tanterior cibarial plate morphogenesis (Organ or Tissue Function)\tS 64315 (Pharmacologic Substance)\tPlakorti (Plakinidae)\tONE VESSEL DISEASE (Disease or Syndrome)", + "output": "anterior cibarial plate morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a complex substitution where the nucleotide sequence at positions 2573 and 2574 of the coding sequence of the EGFR gene has changed from thymine-guanine to guanine-thymine.\nConcepts: Hamartoma of the orbital region (Neoplastic Process)\tNM 005228.3:c.2573 2574delTGinsGT (Cell or Molecular Dysfunction)\tRenal Cell Carcinoma by AJCC v7 Stage (Renal Cell Carcinoma)\tMonitors, Physiologic, Uterine Activity, Telemetric (Medical Device)\tEC 3.6.4.12 (Biologically Active Substance)", + "output": "NM 005228.3:c.2573 2574delTGinsGT (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as it refers to amino acid residues that can be the target for protein kinase C phosphorylation.\nConcepts: Embryo (stage of pregnancy)\tCRQ02-Feel Upset, Worried or Depressed (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\tConcentration loss (Finding)\tPKC Phosphorylation Site (Amino Acid Sequence)\tautologous anti-mesothelin CAR-CD3zeta-4-1-BB-expressing T lymphocytes (Chimeric Antigen Receptor T-cells)", + "output": "PKC Phosphorylation Site (Amino Acid Sequence)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of a gastric neuroendocrine tumor, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.\nConcepts: Typhlitis, Neutropenic (Disease or Syndrome)\tGastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Finding)\tGrade 1 Weight Loss, CTCAE (Weight Loss, CTCAE)\tunsaturated beta-glucuronyl hydrolase activity (Molecular Function)\tOrder Mycoplasmatales (Mollicutes)", + "output": "Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Orthodontics speciality described as recognition and elimination of potential irregularities and malpositions in the developing dentofacial complex.\nConcepts: Interceptive Orthodontics (Orthodontics speciality)\tMemorial Symptom Assessment Scale 7-12 (Intellectual Product)\tNon-Target Enhancing Lesion Response (Finding)\tAngle Tumors (Nervous system neoplasms unspecified malignancy NEC)\tbacteriochlorophyll c binding (Molecular Function)", + "output": "Interceptive Orthodontics (Orthodontics speciality)" + }, + { + "input": "Definition: Toxicology described as header term; physical actions of chemicals on a biological system; includes those studies looking at chemicals interacting and the effect of that reaction on a biological system; prefer narrower terms.\nConcepts: ME (Region of United States of America)\tPerformedClinicalResult.biomarkerIndicator (Biomarker Indicator)\tphysical chemical interaction (Biologic Function)\tcranial nerve 4 development (Organ or Tissue Function)\tFluciclatide (18-F)-containing product (Fluorine-18)", + "output": "physical chemical interaction (Biologic Function)" + }, + { + "input": "Definition: negative regulation of molecular function described as any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule.\nConcepts: down-regulation of binding (negative regulation of molecular function)\thexamethylene bisacetamide inducible 1 (Transcription Regulation Gene)\tOsteogenesis imperfecta, perinatal lethal (Disease or Syndrome)\tMacular dots (Finding)\t(Z,Z,Z)-8,11,14-Icosatrienoate (Fatty Acids)", + "output": "down-regulation of binding (negative regulation of molecular function)" + }, + { + "input": "Definition: something described as image digitization systems designed to provide in-vivo bioluminescent and fluorescent images by imaging sources (i.e., fluorescent and bioluminescent reporters) between the blue and near infrared spectrum. These systems usually include fluorescent light sources that can provide reflected illumination and transillumination through a fiber-optic bundle and bundle switch, a charge coupled device (CCD) camera, emission and excitation filters, a scanning laser system intended only for alignment and surface topography, and imaging software for data acquisition and processing; and the use of a computer with a liquid-crystal display (LCD) monitor. Bioluminescence/fluorescence image digitization systems are used mainly to provide in-vivo images intended to detect cell activity, gene expression, and to assess disease progression in clinical research.\nConcepts: Mobility of a single joint (Organism Function)\tAIP1-IRE1 complex location (Cell Component)\tImage Digitization Systems, Bioluminescence/Fluorescence (Medical Device)\tIn vitro fertilization with surrogacy (Therapeutic or Preventive Procedure)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PAH (Medical Device)", + "output": "Image Digitization Systems, Bioluminescence/Fluorescence (Medical Device)" + }, + { + "input": "Definition: something described as the establishment of viable, functional grafted tissue within the body of a host.\nConcepts: Associations and organizational services (Associations and organizational services, systems and policies)\tAdipose Tissue Deposition (Finding)\tGAIA Level 2 Major Functional Defect (Intellectual Product)\tBone Morphogenetic Protein 15 wt Allele (BMP15 gene)\tReconstitution by graft (Physiologic Function)", + "output": "Reconstitution by graft (Physiologic Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: androst-4-ene-3,17-dione + O2 + 2 H+ + 2 e- = 9alpha-hydroxy-4-androstene-3,17-dione + H2O.\nConcepts: PANSS115 (PANSS Clinical Classification Question)\tBurmese language (Language)\t4-AD 9alpha-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)\tED1-Know Meal Times (Intellectual Product)\tparanasal sinus and nasal cavity squamous cell carcinoma, metastatic (Paranasal sinus and nasal cavity malignant neoplasm stage IV)", + "output": "4-AD 9alpha-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: negative regulation of T cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.\nConcepts: Nephritis, Interstitial (Disorder of soft tissue)\tPlanned Length of Time of Study Subject's Participation (Quantitative Concept)\tnegative regulation of T cell differentiation in thymus (negative regulation of T cell differentiation)\tLAB CGRP (Neuropeptides)\tcentral nervous system structural organization (Morphogenesis)", + "output": "negative regulation of T cell differentiation in thymus (negative regulation of T cell differentiation)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina.\nConcepts: Glottic Cancer Clinical TNM Finding v7 (Finding)\tcolumnar/cuboidal epithelial cell differentiation (epithelial cell differentiation)\tindio (boron group elements)\tlaminar positioning of retinal horizontal cell (Organ or Tissue Function)\teye regeneration (Cell Function)", + "output": "laminar positioning of retinal horizontal cell (Organ or Tissue Function)" + }, + { + "input": "Definition: Pervasive Development Disorder described as a pediatric disorder characterized by normal development for at least the first two years of life followed by a severe regression in language, social interaction, bowel or bladder control, and/or motor skills. The affected individual may also exhibit repetitive and stereotyped patterns of behavior similar to autism.\nConcepts: disintegrative; psychosis (Developmental Disabilities)\tProgesterone Receptor Positive by Immunohistochemistry 81-90 Percent (Progesterone Receptor Positive by Immunohistochemistry)\ttetrahydrogeranylgeranyl-PP reductase activity (Molecular Function)\trex Genes, HTLV-II (Gene or Genome)\tsensory transduction of hot stimulus during thermoception (Organism Function)", + "output": "disintegrative; psychosis (Developmental Disabilities)" + }, + { + "input": "Definition: Africa, Southern described as a country in southern Africa, between South Africa and Zambia, west of Mozambique.\nConcepts: Protease, Serine, 8 (Prostasin) wt Allele (Gene or Genome)\tzimbabwe (Country)\tChest Wall Disease (Thoracic Diseases)\tAndrogen receptor agonist (Types of drugs A-G)\tastral microtubule anchoring at mitotic spindle pole body (Cell Function)", + "output": "zimbabwe (Country)" + }, + { + "input": "Definition: receptor recycling described as the process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.\nConcepts: regulation of eosinophil activation (regulation of leukocyte activation)\tKeloids, Acne (Folliculitis)\tEORTC QLQ-C30 Version 3 - Have You Had Trouble Sleeping (Intellectual Product)\tinsulin receptor recycling (receptor recycling)\tANTHRACENE (Polycyclic Hydrocarbons)", + "output": "insulin receptor recycling (receptor recycling)" + }, + { + "input": "Definition: something described as catalysis of the reaction: isopenicillin N = penicillin N.\nConcepts: Peripheral microtubule doublet of axoneme of cilium (Cell Component)\tSafety (Health Knowledge & Behavior)\tpenicillin-N 5-amino-5-carboxypentanoyl-epimerase activity (Molecular Function)\tCLST (Quantitative Concept)\tCSS0105 (C-SSRS Baseline Questionnaire Question)", + "output": "penicillin-N 5-amino-5-carboxypentanoyl-epimerase activity (Molecular Function)" + }, + { + "input": "Definition: Specimen described as a specimen obtained by biopsy, which is a process of removing tissue from living patients for diagnostic examination.\nConcepts: BASAL GANGLION DISORDER WITH MENTAL RETARDATION (Hereditary disorder of nervous system)\tFrancisella sp (Francisellaceae)\tHerpes esophagitis (Herpesviridae Infections)\tOCCLUSION RETINAL VEIN (Retinal Diseases)\tBiopsy sample (Tissue)", + "output": "Biopsy sample (Tissue)" + }, + { + "input": "Definition: CDRS-R Clinical Classification Question described as children's Depression Rating Scale, Revised (CDRS-R) CDRS-R raw summary score.\nConcepts: intestinal neoplasms (Abdominal Neoplasms)\tEVERY AFTERNOON (Schedule Frequency)\tProkaryotae (Organism)\tCDRS121 (CDRS-R Clinical Classification Question)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Receptor Assay, Progesterone (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Receptor Assay)", + "output": "CDRS121 (CDRS-R Clinical Classification Question)" + }, + { + "input": "Definition: Cell Component described as the space enclosed by the double membrane of a proplastid.\nConcepts: response to interleukin-18 (Cell Function)\tExtrahepatic Bile Duct NET G2 (Extrahepatic Bile Duct Neuroendocrine Tumor)\tPerformedClinicalResult.normalRangeComparisonCode (Intellectual Product)\tPASI0117 (Intellectual Product)\tproplastid stroma (plastid stroma)", + "output": "proplastid stroma (plastid stroma)" + }, + { + "input": "Definition: Number of Groups or Cohorts described as the anticipated number of groups or cohorts that are part of the study.\nConcepts: FRAT1 (Signaling Protein)\t24-methylenecycloartanol 4alpha-methyl oxidase activity (Molecular Function)\tsphingomyelinase activity (phospholipase activity)\tLiver Cancer Clinical TNM Finding v6 (Liver Cancer TNM Finding v6)\tPlanned Number of Cohorts (Quantitative Concept)", + "output": "Planned Number of Cohorts (Quantitative Concept)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as part of brain\nConcepts: Vitellins (Phosphoproteins)\tcongenital emphysema-cryptorchidism-penoscrotal web-deafness-mental retardation syndrome (Disease or Syndrome)\tMeasurement System Incompatibility (Finding)\tMedullary (Cerebellum)\tClimacteric arthritis, site unspecified (Arthropathies NEC)", + "output": "Medullary (Cerebellum)" + }, + { + "input": "Definition: Cytokine assay described as an immunoassay to detect Tumor Necrosis Factor (TNF), which is a potent lymphoid factor, and exerts cytotoxic effects on a wide range of tumor cells and other target cells. Utilizes monoclonal antibody to TNF immobilized on microtitre plate.\nConcepts: Tumor necrosis factor assay, NOS (Laboratory Procedure)\tEuthanasia, Active, Voluntary (Activity)\tStents (Non-Active Implantable Devices)\tMembrane of the Lysosome (Organelles)\tHigh intensity sweetener additive intake (Quantitative Concept)", + "output": "Tumor necrosis factor assay, NOS (Laboratory Procedure)" + }, + { + "input": "Definition: Eukaryote described as minute free-floating animal organisms which live in practically all natural waters.\nConcepts: Thoracic diaphragm (Anterior thoracic region)\tzooplankton (Plankton)\tAfter no treatment, the most common complication is (Clinical or Research Assessment Question)\tcarbamoyl phosphate degradation (organophosphate catabolic process)\tUPD1-Complications:Symptom Orthostasis (UPDRS Questionnaire Question)", + "output": "zooplankton (Plankton)" + }, + { + "input": "Definition: Finding described as severe pain; limiting self care ADL\nConcepts: EMO1-Sadness Responded as Surprise (ERT Functional Test Question)\tVineland adaptive behav scales (Assessment scales)\tGrade 3 Muscle cramp (Muscle Cramp, CTCAE)\tFAC062-I Have Pain (FACT-BRM Version 4 Questionnaire Question)\tAMMONIA (Nitrogen Compounds, Inorganic)", + "output": "Grade 3 Muscle cramp (Muscle Cramp, CTCAE)" + }, + { + "input": "Definition: something described as catalysis of the formation of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine from constituent amino acids and ATP in the presence of magnesium ions and dithioerythritol.\nConcepts: Diseases, Parasitic Liver (Liver diseases)\tImpaired neutrophil killing of staphylococci (Finding)\teukaryotic 48S pre-initiation complex location (translation preinitiation complex)\tACV synthetase activity (ligase activity)\tChronic infantile diarrhoea due to guanylate cyclase 2C overactivity (Digestive system hereditary disorder)", + "output": "ACV synthetase activity (ligase activity)" + }, + { + "input": "Definition: Spatial Concept described as a reference to the third directional coordinate that describes the location of the specimen in the previous storage container before transfer. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: Hereditary mixed polyposis syndrome (Neoplastic Syndromes, Hereditary)\tPerformedSpecimenMove.fromPositionDimensionThree (From Position Dimension Three)\tLuminal A Prostate Cancer (Neoplastic Process)\tAIR SAC (Lung part)\tIVD Test Reagent/Kits, Immunoassay, Neuroendocrine Hormone, Vasoactive Intestinal Peptide (Medical Device)", + "output": "PerformedSpecimenMove.fromPositionDimensionThree (From Position Dimension Three)" + }, + { + "input": "Definition: racemase and epimerase activity, acting on hydroxy acids and derivatives described as catalysis of the reaction: (S)-acetoin = (R)-acetoin.\nConcepts: FAMS0112 (FAMS Questionnaire Question)\tFitzpatrick Skin Classification Response (Intellectual Product)\tProfessional Role (Social Behavior)\tOther Than (General Qualifier)\tacetylmethylcarbinol racemase activity (racemase and epimerase activity, acting on hydroxy acids and derivatives)", + "output": "acetylmethylcarbinol racemase activity (racemase and epimerase activity, acting on hydroxy acids and derivatives)" + }, + { + "input": "Definition: Pharmacologic Substance described as a substance that is being studied as a treatment for cancer. It belongs to a family of drugs called antiestrogens.\nConcepts: PIPENDOXIFENE (Organic Chemical)\tTSH Secreting Tumor of Pituitary (Anterior Pituitary Gland Endocrine Neoplasm)\tNucleated Red Blood Cells/Erythrocytes (Laboratory Procedure)\tcervix cancer, stage II (Neoplastic Process)\tCircumscribed scleroderma NOS (Dermatologic disorders)", + "output": "PIPENDOXIFENE (Organic Chemical)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as monosaccharide transport proteins that function as active symporters. They utilize SODIUM or HYDROGEN IONS to transport GLUCOSE across CELL MEMBRANES.\nConcepts: long-day photoperiodic control of inflorescence development (long-day photoperiodism)\t22q13.33 (Cell Component)\tWD3S11 (Intellectual Product)\tSodium-Glucose Transport Proteins (Biologically Active Substance)\tcervical lymph node enlargement (Neck)", + "output": "Sodium-Glucose Transport Proteins (Biologically Active Substance)" + }, + { + "input": "Definition: negative regulation of cellular process described as any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization.\nConcepts: negative regulation of ribonucleoprotein complex localization (negative regulation of cellular process)\tpolyamine catabolic process (Molecular Function)\tClinical Treatment (Therapeutic procedure)\tPQL01-Wake Up Tired (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tTriamcinolone acetonide preparation (Synthetic glucocorticoid, fluorinated)", + "output": "negative regulation of ribonucleoprotein complex localization (negative regulation of cellular process)" + }, + { + "input": "Definition: cell proliferation involved in metanephros development described as the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.\nConcepts: Genus: Opisthorchis (Opisthorchis)\tmetanephric cap mesenchymal cell proliferation involved in metanephros development (Cell Function)\tasexual sporulation resulting in formation of a cellular spore (asexual sporulation)\tFAC07137 (Intellectual Product)\tCardiac Progenitor Cell (Multipotent Stem Cells)", + "output": "metanephric cap mesenchymal cell proliferation involved in metanephros development (Cell Function)" + }, + { + "input": "Definition: Ocular Physiological Phenomena described as pressure of the fluids of the eye against the tunics; produced by continual renewal of the fluids within the interior of the eye.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Human Metapneumovirus, Antibody (Medical Device)\tVisceral calciphylaxis (Disease or Syndrome)\tIntraocular pressure, NOS (Ocular Physiological Phenomena)\tAnti-HB-EGF MoAb KHK2866 (Immunologic Factor)\tluteinizing hormone signalling pathway (GPCR Signaling Pathway)", + "output": "Intraocular pressure, NOS (Ocular Physiological Phenomena)" + }, + { + "input": "Definition: Intellectual Product described as documentation describing the site feasibility for the given protocol.\nConcepts: obese (Nutritional and Metabolic Diseases)\tSite Selection Documentation (Intellectual Product)\tFeather allergy (Allergy to substance)\tMilligram per Kilogram per Dose (Quantitative Concept)\tGAP Modifying Protein 1 (Biologically Active Substance)", + "output": "Site Selection Documentation (Intellectual Product)" + }, + { + "input": "Definition: something described as an indication that a subject is part of a population group that has a greater chance of contracting a disease or disorder.\nConcepts: FAC050TN (CDISC Questionnaire Terminology)\tphosphomannomutase complex location (Cell Component)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk for 1/2 Mile (Intellectual Product)\tN-4-(5-Nitro-2-furyl)-2-thiazolylformamide (Nitrofurans)\tRISKPOP (Personal Attribute)", + "output": "RISKPOP (Personal Attribute)" + }, + { + "input": "Definition: something described as attitudes of, not toward, counselors.\nConcepts: Eriodictyon californicum / yerba santa leaf (Plant)\t1,3-dichloro-2-propanol breakdown (xenobiotic catabolic process)\tarcitumomab (Immunologic Factor)\tCounselor Attitudes (Attitude)\tconsensus (Social Behavior)", + "output": "Counselor Attitudes (Attitude)" + }, + { + "input": "Definition: Murine leukemia virus described as a positive sense, single-stranded RNA (ssRNA) retrovirus species belonging to the Gammaretrovirus genus. It is a causitive agent for lymphoid leukemia in mice and other mammals.\nConcepts: EvaluatedActivityRelationship.probabilityCode (Intellectual Product)\tContinuity of Care (Treatment (General))\tIndexes as Topic (Intellectual Product)\tSULT1E1 gene (Transferase Gene)\tMLV (Murine leukemia virus)", + "output": "MLV (Murine leukemia virus)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 19q\nConcepts: Great Vessel Tumor (Soft Tissue Neoplasms)\t19q13.2 (Cell Component)\tODI v2.1a - Lifting (Intellectual Product)\tHerpesvirus 2 (gamma), Saimirine (Herpesviridae)\taminoacyltransferase (Acyltransferase)", + "output": "19q13.2 (Cell Component)" + }, + { + "input": "Definition: Neoplastic Process described as a rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma, endocervical type or cervical mucinous adenocarcinoma, intestinal variant.\nConcepts: cholest-4-en-3-one 26-monooxygenase activity (Molecular Function)\tcannabinoid biosynthetic process (Molecular Function)\tVaginal Mucinous Adenocarcinoma (Vaginal adenocarcinoma)\tTranscripts, Nested (Biologically Active Substance)\tmale courtship behavior, licking (Social Behavior)", + "output": "Vaginal Mucinous Adenocarcinoma (Vaginal adenocarcinoma)" + }, + { + "input": "Definition: something described as systems designed with capabilities to perform cataract extraction using phacoemulsification and vitrectomy. These systems include a hollow probe that cuts and emulsifies the lenses using ultrasonic waves (phacoemulsification); a vitreous cutter; irrigation and illumination systems; cautery capabilities; and a channel for aspiration of lens and tissue fragments. The systems also include a vacuum pump and controls for the power level, irrigation rate, and mode of operation. Laser treatment can also be performed using a laser probe to seal blood vessels in the retina (photocoagulation). Cataract phacoemulsification/vitrectomy systems are used for phacoemulsification and cataract removal in the anterior chamber and also for vitreal/retinal surgery in the posterior chamber of the eye.\nConcepts: MIRN222 (Gene or Genome)\tCataract Extraction Phacoemulsification/Vitrectomy Systems (Surgical Equipment, Ophthalmological)\tReduced Walking Ability (Clinical or Research Assessment Answer)\tMisassembled During Installation (Installation-Related Problem)\tInferior maxillary nerve (Mandibular nerve and its branches)", + "output": "Cataract Extraction Phacoemulsification/Vitrectomy Systems (Surgical Equipment, Ophthalmological)" + }, + { + "input": "Definition: Inherited platelet disorder described as syndrome is characterised by haematological anomalies (Fanconi anaemia, leukaemia and lymphoma) often appearing during childhood. Anomalies of the limbs and hands are also present: bifid or hypoplastic thumbs, cutaneous syndactyly and ulnar and radial defects. The syndrome has been described in several families. Transmission is autosomal dominant.\nConcepts: Asialoglycoprotein Receptor, Hepatic (Amino Acid, Peptide, or Protein)\tPQL1214 (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question)\tglycol (nicotinamide adenine dinucleotide (phosphate)) dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tCSS0119 (C-SSRS Baseline Questionnaire Question)\tWT limb-blood syndrome (Multiple malformation syndrome with limb defect as major feature)", + "output": "WT limb-blood syndrome (Multiple malformation syndrome with limb defect as major feature)" + }, + { + "input": "Definition: Lyophilized powder described as solid preparation consisting of a freeze-dried powder intended to be dispersed in the specified liquid to obtain a nasal spray, suspension.\nConcepts: IVD Panels, Human Genetics, Bone Disorder, Paget Disease, Mutation (Medical Device)\tATLAS Clinical Classification Test Code (Intellectual Product)\tNasal spray, lyophilisate for suspension (Lyophilized powder)\tProstate Saturation Needle Biopsy (Transperineal Biopsy)\tanti-MUC1 monoclonal antibody BTH1704 (Antineoplastic Antibody)", + "output": "Nasal spray, lyophilisate for suspension (Lyophilized powder)" + }, + { + "input": "Definition: Virus Physiological Processes described as insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.\nConcepts: Lymphoid Hyperplasia, Reactive (Lymphatic system disorders NEC)\tPKC Phosphorylation Site (Phosphorylation Site)\tintracranial (Intra-location)\tfibulin 3 (Ligand Binding Protein Gene)\tVirus Integration (Virus Physiological Phenomena)", + "output": "Virus Integration (Virus Physiological Phenomena)" + }, + { + "input": "Definition: something described as glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteoglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin.\nConcepts: Chondroitin / Heparan Sulfate Biosynthesis (Molecular Function)\tupregulation of cardiac muscle development (Organ or Tissue Function)\tTank (Manufactured Object)\tVery-Low-Birth-Weight Infants (Disease or Syndrome)\tMDM2 Antagonist RO5045337 (Pharmacologic Substance)", + "output": "Chondroitin / Heparan Sulfate Biosynthesis (Molecular Function)" + }, + { + "input": "Definition: Papillary Epithelial Neoplasm described as an adenoma characterized by the presence of papillary epithelial patterns.\nConcepts: Intralesional Triamcinolone Regimen (Therapeutic or Preventive Procedure)\tNodular Lymphocyte Predominant Hodgkin Lymphoma (Neoplastic Process)\tAntagonists, Purinergic Receptor (Pharmacologic Substance)\tdown-regulation of intraciliary anterograde transport (regulation of intraciliary anterograde transport)\tPapillary Adenomas (Papillary Epithelial Neoplasm)", + "output": "Papillary Adenomas (Papillary Epithelial Neoplasm)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the cleavage of the N-glycosidic bond between the 5'-pyrimidine residue in cyclobutadipyrimidine (in DNA) and the corresponding deoxy-D-ribose residue.\nConcepts: endosulfan ether monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\tpyrimidine dimer DNA glycosylase activity (catalytic activity, acting on DNA)\tgustatory receptor activity (transmembrane signaling receptor activity)\tPenile Cancer TNM Finding v8 (Finding)\tMiniantibody (Peptides)", + "output": "pyrimidine dimer DNA glycosylase activity (catalytic activity, acting on DNA)" + }, + { + "input": "Definition: something described as geriatric Depression Scale (GDS) Are you hopeful about the future?\nConcepts: Secondary malignant neoplasm of penis, NOS (Neoplastic Process)\tGDS0105 (Intellectual Product)\tanti-human chorionic gonadotropin vaccine (Pharmacologic Substance)\tInterlobular Artery (Body Part, Organ, or Organ Component)\tCoiled-Coil Serine-Rich Protein 1 wt Allele (CCSER1 gene)", + "output": "GDS0105 (Intellectual Product)" + }, + { + "input": "Definition: Nuclear medicine study of systems described as the infusion of radioactive substances such as microspheres containing yttrium-90 (90Y), iodine-131 (131I) ethiodised oil, and similar agents into the hepatic artery.\nConcepts: adrenergic receptor signalling pathway involved in positive regulation of heart rate (Molecular Function)\tTARE - Transarterial radioembolization (Nuclear medicine study by site)\tRetinoph prematr,stage 1 (Retinopathy of Prematurity Finding)\tOver the past 7 days, what was the SEVERITY of your CONSTIPATION at its WORST (Intellectual Product)\tElectrodes, Cardiac, Electrocardiography, Transcutaneous (Medical Device)", + "output": "TARE - Transarterial radioembolization (Nuclear medicine study by site)" + }, + { + "input": "Definition: Cell Component described as a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE; found in blood and carries lipids from body tissues to the liver as part of the reverse cholesterol transport process.\nConcepts: HDL2 (plasma lipoprotein particle)\tribonuclease V activity (Genetic Function)\tPortable shelter (Protective Devices)\tPS-1 (Biologically Active Substance)\tDifficulties, Ambulatory (other orthopedic disorders)", + "output": "HDL2 (plasma lipoprotein particle)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Toddler Parent Report - In the past 7 days, how much of a problem has this been for your child: My child takes a long time to eat.\nConcepts: metavinculin (Gene or Genome)\tBarley smut extract (Immunologic Factor)\tPQL1815 (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)\tregulation of GEF (regulation of GTP binding)\tUndefined Christian Science care narrative required (Christian Science care)", + "output": "PQL1815 (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)" + }, + { + "input": "Definition: negative regulation of development of symbiont on or near host surface described as any process that stops, prevents, or reduces the frequency, rate or extent of spore encystment on host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: negative regulation of spore encystment on host (negative regulation of development of symbiont on or near host surface)\tStage IIIB Esophageal Squamous Cell Carcinoma (Stage III Esophageal Squamous Cell Carcinoma AJCC v7)\tuniversal prkxns edkshn (Educational Activity)\tAPPLIER, CERCLAGE (Medical Device)\tgalactosylononitol-raffinose galactosyltransferase activity (Molecular Function)", + "output": "negative regulation of spore encystment on host (negative regulation of development of symbiont on or near host surface)" + }, + { + "input": "Definition: Inheritance Patterns described as genes that are located on the Y CHROMOSOME.\nConcepts: BILE (Body Substance)\tNRS (Intellectual Product)\tProviding selenium based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis. (Mineral supplementation)\tY-Chromosome Gene (Gene or Genome)\tIntellectual disability, facial dysmorphism, hand anomalies syndrome (Intellectual Disability)", + "output": "Y-Chromosome Gene (Gene or Genome)" + }, + { + "input": "Definition: MHIS-NACC Questionnaire Question described as modified Hachinski Ischemic Scale-NACC Version - Stepwise deterioration (re: cognitive status).\nConcepts: ARD1 protein, human (Amino Acid, Peptide, or Protein)\thydroxylysine (Biologically Active Substance)\tMHIS0102 (Intellectual Product)\tMonohydrochloride Monohydrate, Ciprofloxacin (ciprofloxacin)\tDNA ligase activity (catalytic activity, acting on DNA)", + "output": "MHIS0102 (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of hepatocyte apoptotic process.\nConcepts: oligosaccharyltransferase III complex location (oligosaccharyltransferase complex)\tIn vitro fertilization with surrogacy (Therapeutic or Preventive Procedure)\tEntity Name Person Data Type (Qualitative Concept)\tTularemia (Tick-Borne Diseases)\tup-regulation of hepatocyte apoptotic process (Cell Function)", + "output": "up-regulation of hepatocyte apoptotic process (Cell Function)" + }, + { + "input": "Definition: something described as a hemodialysis system and accessories is a device that is used as an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and that consists of an extracorporeal blood system, a conventional dialyzer, a dialysate delivery system, and accessories. Blood from a patient flows through the tubing of the extracorporeal blood system and accessories to the blood compartment of the dialyzer, then returns through further tubing of the extracorporeal blood system to the patient. The dialyzer has two compartments that are separated by a semipermeable membrane. While the blood is in the blood compartment, undesirable substances in the blood pass through the semipermeable membrane into the dialysate in the dialysate compartment. The dialysate delivery system controls and monitors the dialysate circulating through the dialysate compartment of the dialyzer. (1) The extracorporeal blood system and accessories consists of tubing, pumps, pressure monitors, air foam or bubble detectors, and alarms to keep blood moving safely from the blood access device and accessories for hemodialysis (Sec. 876.5540) to the blood compartment of the dialyzer and back to the patient. (2) The conventional dialyzer allows a transfer of water and solutes between the blood and the dialysate through the semipermeable membrane. The semipermeable membrane of the conventional dialyzer has a sufficiently low permeability to water that an ultrafiltration controller is not required to prevent excessive loss of water from the patient's blood. This conventional dialyzer does not include hemodialyzers with the disposable inserts (Kiil type) (Sec. 876.5830) or dialyzers of high permeability (Sec. 876.5860). (3) The dialysate delivery system consists of mechanisms that monitor and control the temperature, conductivity, flow rate, and pressure of the dialysate and circulates dialysate through the dialysate compartment of the dialyzer. The dialysate delivery system includes the dialysate concentrate for hemodialysis (liquid or powder) and alarms to indicate abnormal dialysate conditions. This dialysate delivery system does not include the sorbent regenerated dialysate delivery system for hemodialysis (Sec. 876.5600), the dialysate delivery system of the peritoneal dialysis system and accessories (Sec. 876.5630), or the controlled dialysate delivery system of the high permeability hemodialysis system (Sec. 876.5860). (4) Remote accessories to the hemodialysis system include the unpowered dialysis chair without a scale, the powered dialysis chair without a scale, the dialyzer holder set, dialysis tie gun and ties, and hemodialysis start/stop tray.\nConcepts: MIR210 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tBoswellia Serrata Roxb. Ex Colebr. Oleo-gum-resin (B [Preparations])\tCaecostomy (Anastomosis of large intestine to large intestine)\tMSQL136 (MSQOL-54 Questionnaire Question)\tSYSTEM, BLOOD, EXTRACORPOREAL AND ACCESSORIES (Medical Device)", + "output": "SYSTEM, BLOOD, EXTRACORPOREAL AND ACCESSORIES (Medical Device)" + }, + { + "input": "Definition: Terminology Subset described as terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC).\nConcepts: Rays, Fish (fish )\tSYSTEM, DIALYSATE DELIVERY, RECIRCULATING, SINGLE PASS (Medical Device)\tChromobacterium (Chromobacterium group)\tGLOVE, PROTECTIVE, RADIOGRAPHIC (Medical Device)\tCPTAC Terminology (Terminology Subset)", + "output": "CPTAC Terminology (Terminology Subset)" + }, + { + "input": "Definition: positive regulation of blood coagulation described as any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway.\nConcepts: Pectin-containing product (Chemical categorised functionally)\tPleural Mesothelioma Pathologic TNM Finding v7 (Pleural Mesothelioma TNM Finding v7)\tpositive regulation of blood coagulation, extrinsic pathway (regulation of blood coagulation, extrinsic pathway)\tN-2-Pyridylsulfanilamide (S [Preparations])\tReactions, Biuret (Chemistry Techniques, Analytical)", + "output": "positive regulation of blood coagulation, extrinsic pathway (regulation of blood coagulation, extrinsic pathway)" + }, + { + "input": "Definition: Cell Cycle Checkpoints described as a mitotic cell cycle checkpoint that originates from the spindle and delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and oriented, the completion of anaphase until chromosomes are attached to the spindle, or mitotic exit and cytokinesis when the spindle does not form.\nConcepts: Mitotic Spindle Checkpoints (Cell Function)\tWinged Helix/Forkhead Transcription Factor (Amino Acid, Peptide, or Protein)\tcerebral hypoxia (Cerebrovascular and spinal necrosis and vascular insufficiency)\tAnti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47 (Amino Acid, Peptide, or Protein)\tThere is usually a television turned on somewhere in our home (Intellectual Product)", + "output": "Mitotic Spindle Checkpoints (Cell Function)" + }, + { + "input": "Definition: Organic Chemical described as a radiopharmaceutical containing the purine analog fludarabine that is labeled with the radioisotope fluorine F18 with potential use as a tumor imaging agent upon positron emission tomography (PET). After intravenous administration, the fludarabine is selectively taken up by tumor cells. The radioisotope moiety is detected using PET, which allows imaging and quantification of both the biodistribution of fludarabine and the presence of tumor cells. This could identify tumors and select patients that will likely respond to fludarabine treatment. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C115978\" active clinical trials using this agent.\nConcepts: Amoxicillinum (Anti-Bacterial Agents)\tFocal verbal automatism seizure (Focal automatism seizure)\t18F-Fludarabine (Organic Chemical)\tMelanoma of the Skin pM1b(0) TNM Finding v8 (Finding)\tCopper Cu 64 Trastuzumab (Radioimmunoconjugates)", + "output": "18F-Fludarabine (Organic Chemical)" + }, + { + "input": "Definition: Stippling of the epiphyses of the proximal phalanges of the hand described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphysis of the proximal phalanx of the 3rd finger.\nConcepts: Gallbladder Carcinoma TNM Finding v8 (Hepatobiliary System Cancer TNM Finding v8)\tnicotine lozenge (Clinical Drug)\tTranscription Factors, General (Amino Acid, Peptide, or Protein)\tStippling of the epiphysis of the proximal phalanx of the 3rd finger (Stippling of the epiphyses of the 3rd finger)\tCytokeratin-9 (Keratins, Type II)", + "output": "Stippling of the epiphysis of the proximal phalanx of the 3rd finger (Stippling of the epiphyses of the 3rd finger)" + }, + { + "input": "Definition: Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7 described as gastric neuroendocrine tumor penetrating subserosa.\nConcepts: downregulation of DNA N-glycosylase activity (regulation of DNA N-glycosylase activity)\tGastric Neuroendocrine Tumor pT3 TNM Finding v7 (Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7)\tregulation of citrulline--aspartate ligase activity (Molecular Function)\tpeptidyl-arginine hydroxylation (peptidyl-arginine modification)\tDNA Test, HPV (DNA analysis)", + "output": "Gastric Neuroendocrine Tumor pT3 TNM Finding v7 (Gastric Neuroendocrine Tumor Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: EGFR Exon 19 Deletion Mutation described as a deletion of 18 nucleotides from the coding sequence of the EGFR gene from position 2235 through 2252.\nConcepts: Hemostatic Agents, Emergency/Trauma (Device Labeled for Single Use)\tNTRK RECEPTOR 002 (Receptor)\tFACTVWMU (von Willebrand's factor)\tCompound Q (Pharmacologic Substance)\tHER1 c.2235 2252del18 (Cell or Molecular Dysfunction)", + "output": "HER1 c.2235 2252del18 (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as this gene is involved in the monoubiquitination of substrate proteins.\nConcepts: yttrium Y 90 anti-CD66 monoclonal antibody BW 250/183 (Indicator, Reagent, or Diagnostic Aid)\tstem cell development (Cell development)\tUBIQUITIN-CONJUGATING ENZYME E2O (Gene or Genome)\t5: 156540485-156614687 (Spatial Concept)\tmannose biosynthetic process (mannose metabolic process)", + "output": "UBIQUITIN-CONJUGATING ENZYME E2O (Gene or Genome)" + }, + { + "input": "Definition: Portion of vitreous humor described as vitreous humor which constitutes the vitreous body proper of the eye.\nConcepts: Chloride, Hydrogen (Chlorine Compounds, Inorganic)\tVitreous humor proper (Portion of vitreous humor)\tKlebsiella aerogenes (Hormaeche and Edwards 1960) Tindall et al. 2017 (Enterobacter)\tregulation of emericellamide A anabolism (Molecular Function)\t10: 135229746-135241501 (Chromosome 10 Physical Location)", + "output": "Vitreous humor proper (Portion of vitreous humor)" + }, + { + "input": "Definition: Public Health Dentistry described as the practice of dentistry concerned with preventive as well as diagnostic and treatment programs in a circumscribed population.\nConcepts: COMMUNITY DENT (Public Health Dentistry)\tgamma-tubulin complex localization to nuclear side of mitotic spindle pole body (Cell Function)\tCells, Stem (Leukocytes)\tGrade 1 Neonatal Gastrointestinal Bleeding, Adverse Event (Finding)\tMinimization Randomization (Adaptive Randomization)", + "output": "COMMUNITY DENT (Public Health Dentistry)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of AMPA selective glutamate receptor activity.\nConcepts: Signal Frequency (Frequencies)\tStress bismuth subsalicylate (Pharmacologic Substance)\tLoss of Chromosome 21 (Chromosomal Loss)\tpolyhydroxy compound (Alcohols)\tregulation of AMPA receptor activity (regulation of neurotransmitter receptor activity)", + "output": "regulation of AMPA receptor activity (regulation of neurotransmitter receptor activity)" + }, + { + "input": "Definition: Protein Family described as activator Protein 2. Originally identified as a cellular transcription factor that binds the enhancer region of SV40. It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma. AP-2 is developmentally regulated and inducible by RET.\nConcepts: Prospective Cohort Study (Research Activity)\tpeptidyl-cysteine modification to S-amindino-L-cysteine (peptidyl-cysteine modification)\tMiddle Ear Microsurgery Curettes (Curettes, Surgical, Middle Ear)\turea transmembrane transport (Cell Function)\tActivator Protein-2 Family Transcription Factor (Biologically Active Substance)", + "output": "Activator Protein-2 Family Transcription Factor (Biologically Active Substance)" + }, + { + "input": "Definition: Molecular Function described as upregulation of the activity of the enzyme ornithine decarboxylase.\nConcepts: Anal Sacs (Anus part)\tornithine decarboxylase activator activity (Molecular Function)\tElectrocardiogram Domain (Intellectual Product)\tspinobulbar tract (Body Part, Organ, or Organ Component)\tmadia elegans/common madia (Pharmacologic Substance)", + "output": "ornithine decarboxylase activator activity (Molecular Function)" + }, + { + "input": "Definition: Sideroblastic anemia described as an inherited form of sideroblastic anemia.\nConcepts: blood pressure regulation by capillary fluid shift (regulation of systemic arterial blood pressure by physical factors)\tNo known allergy (Finding)\tSideroblastic anemia, hereditary (Disease or Syndrome)\tBenign paraganglioma (Endocrine Gland Neoplasms)\tISLLOQ (Lower Limit of Quantitation)", + "output": "Sideroblastic anemia, hereditary (Disease or Syndrome)" + }, + { + "input": "Definition: something described as terminology relevant to the test names that describe findings about a nutrition event or intervention.\nConcepts: Acidivorax delafieldii (Pseudomonas)\tSDTM-NTFATS (CDISC SDTM Terminology)\tDual-Energy CEDM (Contrast enhanced spectral mammography)\tAnticipatory grieving (Mental Process)\tglutamine breakdown to fumarate, using glutamate synthase (glutamine catabolic process to fumarate)", + "output": "SDTM-NTFATS (CDISC SDTM Terminology)" + }, + { + "input": "Definition: something described as a unit of mass commonly used to express the molar mass of a substance in milligram(s) per mole.\nConcepts: CABIN1 Gene (Gene or Genome)\tMilligram per Mole (Quantitative Concept)\treelin complex (Cell Component)\tE7(86-93) (Amino Acid, Peptide, or Protein)\tImmunity, Humoral (Organism Function)", + "output": "Milligram per Mole (Quantitative Concept)" + }, + { + "input": "Definition: Abnormal podocyte morphology described as increase in size of the podocytes of the renal glomerulus.\nConcepts: Administers care to tube and drains (Therapeutic or Preventive Procedure)\tR8 cell fate specification (Cell Function)\tPodocyte hypertrophy (Finding)\tI 6.2 (Technion ES Cell Line)\tclathrin-sculpted glutamate transport vesicle lumen (cytoplasmic vesicle lumen)", + "output": "Podocyte hypertrophy (Finding)" + }, + { + "input": "Definition: Finding by Site or System described as normal or abnormal findings related to the nervous system.\nConcepts: ESRSA108 (ESRS-A Clinical Classification Question)\tNeurological findings (Signs and Symptoms)\tOSPR (Office of the Director)\tPower Switch Device (Manufactured Object)\tAcid-base regulation: metabolic alkalosis (Therapeutic or Preventive Procedure)", + "output": "Neurological findings (Signs and Symptoms)" + }, + { + "input": "Definition: Medical Device described as lasers designed to produce pulsed alexandrite and dye beams combined in one unit that are intended for dermatologic treatments. The beams produced by the laser with alexandrite as an active medium usually operates at a wave length of 755 nm (red) while the radiation from the dye laser is typically at 595 nm (yellow). The combined systems may be used in the same dermatologic applications that each of the individual alexandrite and dye lasers are intended. The combined units, using the laser sources sequentially in the same session or each one in alternative sessions, are particularly useful for treatment of keratotic follicular papules (i.e., keratosis pilaris) and capillary vascular malformations (e.g., port wine stains). Some systems are also used for cosmetic (plastic surgery) treatments.\nConcepts: Q-LES-Q - Felt Well Coordinated (Q-LES-Q Questionnaire Question)\tLasers, Dye/Alexandrite, Dermatologic (Medical Device)\tGranulocytes/Leukocytes (Laboratory Procedure)\tindolent adult non-Hodgkin's lymphoma stage IV (Indolent Adult Non-Hodgkin Lymphoma)\tPregnenolone (Progesterone Congeners)", + "output": "Lasers, Dye/Alexandrite, Dermatologic (Medical Device)" + }, + { + "input": "Definition: Acute on chronic pancreatitis described as a disorder characterized by recurrent episodes of pancreatitis that start at a young age. It is caused by mutations in the PRSS1 or SPINK1 genes. Patients are at a high risk of developing pancreatic carcinoma.\nConcepts: Kunjin virus (West Nile virus)\tPancreatitis, Hereditary (Disease or Syndrome)\tflu prevention (Other vaccination or inoculation)\tClonal Nevus (Neoplastic Process)\tPQL0620 (Intellectual Product)", + "output": "Pancreatitis, Hereditary (Disease or Syndrome)" + }, + { + "input": "Definition: Structure of brachiocephalic vein described as a vein originating within the occipital region that descends along the cervical vertebrae while receiving numerous tributaries to ultimately empty into the brachiocephalic vein.\nConcepts: Thapsia L., 1753 (Daucinae)\tHemidesmus R.Br., 1811 (Family Asclepiadaceae - milkweed)\tStaphylococcus xylosus Schleifer and Kloos 1975 (Bacterium)\tRPQ01-Taking Longer to Think (RPQ Questionnaire Question)\tVena vertebralis (Vascular structure of cervical spine)", + "output": "Vena vertebralis (Vascular structure of cervical spine)" + }, + { + "input": "Definition: Finding described as palpebral conjunctiva +/- fornix +/- caruncle.\nConcepts: maturation of SSU-rRNA (Genetic Function)\tParticipant Chief (Research Personnel)\tMuscle of the Tympanum (Head and Neck Muscle)\tOcular Adnexal Lymphoma pT1b TNM Finding v7 (Finding)\tIVD Test Reagent/Kits, Cytology/Histology, Embedding Media, Electron Microscopy (IVD Test Reagent/Kits, Cytology/Histology, Embedding Media)", + "output": "Ocular Adnexal Lymphoma pT1b TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other.\nConcepts: Lugano Classification Stage II Bulky Childhood Hodgkin Lymphoma AJCC v8 (Lugano Classification Stage II Bulky Hodgkin Lymphoma AJCC v8)\tSuppliers; Durable Medical Equipment & Medical Supplies (Health Care Related Organization)\tsulphaguanidine (Anti-Bacterial Agents)\tMyocardial scintigraphy (Diagnostic Procedure)\tnitric oxide transmembrane transporter activity (neurotransmitter transmembrane transporter activity)", + "output": "nitric oxide transmembrane transporter activity (neurotransmitter transmembrane transporter activity)" + }, + { + "input": "Definition: Cocaine Dependence described as physical or psychological dependence on the drug cocaine which is associated with a pattern of continuous use.\nConcepts: cytochrome bc1 activity (electron transfer activity)\tMegaloblastoid Changes Present (Physical shape)\tGel, dentifrice (Gel)\tCocaine dependence, continuous (Mental or Behavioral Dysfunction)\tPhysician Listens to How I Would Like to do Things (Intellectual Product)", + "output": "Cocaine dependence, continuous (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Special Education described as action taken utilizing medical, family, school, social, or mental health resources and aimed at infants and children at risk for, or in the early stages of mental, physical, learning, or other disorders.\nConcepts: DISSEMINATED LUPUS ERYTHEMATOSUS (Collagen Diseases)\tInfluenza, Swine (Influenza)\tEARLY INTERVENTION EDUC (Management procedure)\tInitial Concentration Normalized by Dose (Quantitative Concept)\tAcid Anhydrolase, Organophosphorus (Phosphoric Triester Hydrolases)", + "output": "EARLY INTERVENTION EDUC (Management procedure)" + }, + { + "input": "Definition: antagonists & inhibitors described as any substance or state which suppresses, prevents, or opposes the action of aminoacids.\nConcepts: OSSICULAR REPLACE (Otologic Surgical Procedures)\tDry powder inhaler (Nebulizers and Vaporizers)\tOzone (Sterilization for infection control)\tsynaptonemal complex formation (chromosome organization involved in meiotic cell cycle)\taminoacid inhibitor (antagonists & inhibitors)", + "output": "aminoacid inhibitor (antagonists & inhibitors)" + }, + { + "input": "Definition: Eukaryote described as marine bivalve mollusks especially of the genus MYTILUS or freshwater bivalve mollusks, especially the genera UNIO and ANODONTA. Mussels usually have a larva (glochidia), and require a fish host to complete development.\nConcepts: ANAL PAIN (Pain)\tNanoparticles (Nanostructured Materials)\tColonic Hemorrhage, CTCAE 5 (Finding)\tPQL08-Family Has Lot of Problems (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)\tMussel, NOS (Eukaryote)", + "output": "Mussel, NOS (Eukaryote)" + }, + { + "input": "Definition: Thiophenes described as an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.\nConcepts: function lungs normal (Lung finding)\tacid alpha-lipoic (Medicinal product categorized by structure)\tAtrial Closure Device (Medical Device)\tTunneling Microscopies, Scanning (Laboratory Procedure)\tmicrocirculation (Blood Vessel)", + "output": "acid alpha-lipoic (Medicinal product categorized by structure)" + }, + { + "input": "Definition: Pharmacologic Substance described as a non-metabolizable synthetic amino acid, formed through the cyclization of the amino acid leucine, with immunosuppressive, antineoplastic, and cytostatic activities. Cycloleucine competitively inhibits the enzyme methionine adenosyltransferase, resulting in the inhibition of S-adenosylmethionine (SAM) synthesis from methionine and ATP, and subsequent nucleic acid methylation and polyamine production; RNA, and perhaps to a lesser extent, DNA biosyntheses and cell cycle progression are finally disrupted. This agent is also a competitive inhibitor at the glycine modulatory site of the N-methyl-D-aspartate (NMDA) receptor.\nConcepts: Grade 2 Anal stenosis (Finding)\tinositol metabolic process (Molecular Function)\tAminocyclopentanecarboxylic Acid (Cyclopentanes)\tSpeckled calcifications in of the end part of the middle bone of the 2nd toe (Stippling of the epiphyses of the 2nd toe)\tgerm-line cyst formation (Organ or Tissue Function)", + "output": "Aminocyclopentanecarboxylic Acid (Cyclopentanes)" + }, + { + "input": "Definition: Antibiotics, Antineoplastic described as a kind of cancer treatment drug\nConcepts: chemical synaptic transmission, postsynaptic (cell surface receptor signaling pathway involved in cell-cell signaling)\tPolycythemia, NOS (Leukopenia)\tMammary lobe (Breast part)\tActinomycin A IV (Antibiotics, Cytotoxic)\tStage IB2 Cervical Cancer AJCC v8 (Stage IB Cervical Cancer AJCC v8)", + "output": "Actinomycin A IV (Antibiotics, Cytotoxic)" + }, + { + "input": "Definition: Inorganic salt/vitamin prophylaxis described as providing calcium based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis.\nConcepts: ADL03-Talk Without Repeating (Intellectual Product)\tImmunologic Technics (Laboratory Procedure)\tCalcium supplement therapy (Therapeutic or Preventive Procedure)\tAcrofacial dysostosis, Nager type (Multiple malformation syndrome with facial-limb defects as major feature)\tPartial duplication of the innermost bone of big toe (Duplication of the proximal phalanx of the hallux)", + "output": "Calcium supplement therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Structure of lymph node of thorax described as a lymph node located adjacent to the trachea within the mediastinum.\nConcepts: Paratracheal Lymph Node (Lymph Node by Anatomic Site)\thyalin (Extracellular)\tMorphine Derivatives Including Cocaine (Pharmacologic Substance)\tElectric Capacitance Unit (Unit of Electricity and Magnetism)\tCortical microcysts (Renal cortical cysts)", + "output": "Paratracheal Lymph Node (Lymph Node by Anatomic Site)" + }, + { + "input": "Definition: something described as an inland sea enclosed by Europe on the west and north, by Asia on the east, and Africa on the south.\nConcepts: Propionicibacterium propionicum (Bacterium)\tMicroscopic Findings Laterality (Organism Attribute)\tMediterranean Sea (Geographic Area)\tBiliary tract disorders NOS (Finding of biliary tract)\tFA-H Gene Mutation (Gene Mutant)", + "output": "Mediterranean Sea (Geographic Area)" + }, + { + "input": "Definition: Clinical or Research Facility described as the Flow Cytometry Shared Resource provides Cancer Center investigators with following support: analytical flow cytometry, sorting of cell subpopulations utilizing various criteria, such as intrinsic cell properties, e.g. DNA content, Green Fluorescent Protein, or extrinsic properties, such as molecular markers identified by fluorescently-labelled monoclonal antibodies, automated magnetic cell sorting. The resource operates, maintains, and upgrades instrumentation for flow cytometric analysis and cell sorting, advises in the design of experiments and contributes consultation in analysis of data.\nConcepts: Flow Cytometry Shared Resource (Clinical or Research Facility)\tpregnancy, Hodgkin's disease during (Neoplastic Process)\tContraceptive coitus interruptus (Coitus)\tAccessory Pancreatic Duct (Body Part, Organ, or Organ Component)\tDo mouth symptoms partially limit your oral intake (Mouth Symptoms Limit Oral Intake)", + "output": "Flow Cytometry Shared Resource (Clinical or Research Facility)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a dopamine stimulus.\nConcepts: Arterial Access Site (Anatomic Site)\tFILOBASIDIUM UNIGUTTULATUM (Filobasidium)\tresponse to dopamine (response to catecholamine)\tlight-harvesting complex, peripheral complex (Cell Component)\tFamilial Hypokalemia-Hypomagnesemia (Renal and urinary tract disorders congenital NEC)", + "output": "response to dopamine (response to catecholamine)" + }, + { + "input": "Definition: Cell Component described as an extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm.\nConcepts: Composite graft of skin and soft tissues (Skin graft material)\textracellular microvesicle (Extracellular Vesicles)\tABX-EGF, Clone E7.6.3 (Antibodies, Monoclonal, Humanized)\tBCMA (Tumor Necrosis Factor Receptor)\tmicrographic mohs surgery (Microscopically controlled excision of skin lesion)", + "output": "extracellular microvesicle (Extracellular Vesicles)" + }, + { + "input": "Definition: Organic Chemical described as six-carbon sugar alcohol with about half the sweetness of sucrose; occurs naturally and is also produced synthetically from glucose.\nConcepts: Hand-Held Computer (Manufactured Object)\tK2 (Gene or Genome)\tProtein Regulator of Cytokinesis 1 (Cell Cycle Proteins)\tD-Glucitol (Carbohydrates)\tspinal muscular atrophy-mental retardation syndrome (Disease or Syndrome)", + "output": "D-Glucitol (Carbohydrates)" + }, + { + "input": "Definition: Finding described as a physical activity not elsewhere listed or specified.\nConcepts: C5a, Complement (Immunologic Factor)\tDalfampridine (D [Preparations])\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue, Single-Stranded DNA Antibody (IVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue)\tCRL4 complex location (Cell Component)\tOther physical activity, specify (Physical activity)", + "output": "Other physical activity, specify (Physical activity)" + }, + { + "input": "Definition: Genetic Function described as calcium-mediated signaling that results in positive regulation of transcription from an RNA polymerase II promoter.\nConcepts: PQL1511 (Intellectual Product)\tSIQ0221 (SIQ-JR Questionnaire Question)\tStructure of right testicular vein (Structure of testicular vein)\tpositive regulation of transcription from Pol II promoter by calcium-mediated signaling (Calcium Signaling)\tUnresectable Epithelioid Hemangioendothelioma (Epithelioid hemangioendothelioma)", + "output": "positive regulation of transcription from Pol II promoter by calcium-mediated signaling (Calcium Signaling)" + }, + { + "input": "Definition: Molecular Function described as the formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein.\nConcepts: protein C-terminal amidation (C-terminal protein amino acid modification)\tHuman herpesvirus 6 infc (Disease or Syndrome)\tAmphipathic Alpha Helix (Protein Conformation, alpha-Helical)\tBiliary Manometric Catheters (Medical Device)\tuncaria rhynchophylla/gou te (Plant)", + "output": "protein C-terminal amidation (C-terminal protein amino acid modification)" + }, + { + "input": "Definition: Intellectual Product described as neuropathic Pain Scale - Which of the following best describes the time quality of your pain? Please check only one answer.\nConcepts: CALIBRATOR FOR CELL INDICES (Medical Device)\tPelvis Cancer pT3b TNM Finding v8 (Finding)\tINDINAVIR (Allergen class)\tIntended Outcome of Use (Medical Product Usage and Evaluation)\tNPS01-Describe Time Quality Of Your Pain (NPS Questionnaire Question)", + "output": "NPS01-Describe Time Quality Of Your Pain (NPS Questionnaire Question)" + }, + { + "input": "Definition: Serine/Threonine Protein Kinase Gene described as this gene plays a role in cell survival.\nConcepts: Endometrial disorder NOS (UTERINE/ENDOMETRIAL DISORDERS)\tMonoiodotyrosine (Amino Acid, Peptide, or Protein)\tether metabolism (organic substance metabolic process)\tFAST (Gene or Genome)\tSubglottic Cancer pT2 TNM Finding v8 (Subglottic Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "FAST (Gene or Genome)" + }, + { + "input": "Definition: Blood smear finding described as abnormally increased variability in the size of platelets.\nConcepts: Heterocyclic Amine Carcinogen (Organo-nitrogen Carcinogen)\tPlatelet anisocytosis (Blood smear finding)\tarthritides (Inflammatory disorder)\tLEVORPHANOL (Opioid Agonist [EPC])\tProduct containing ranitidine bismuth citrate (R [Preparations])", + "output": "Platelet anisocytosis (Blood smear finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as the fumarate salt form of gilteritinib, an orally bioavailable inhibitor of the receptor tyrosine kinases (RTKs) FMS-like tyrosine kinase 3 (FLT3; STK1; FLK2), AXL (UFO; JTK11), anaplastic lymphoma kinase (ALK; CD246), and leukocyte receptor tyrosine kinase (LTK), with potential antineoplastic activity. Upon administration, gilteritinib binds to and inhibits both the wild-type and mutated forms of FLT3, AXL, ALK and LTK. This may result in an inhibition of FLT3-, AXL-, ALK-, and LTK-mediated signal transduction pathways and reduced proliferation in cancer cells that overexpress these RTKs. FLT3, AXL, ALK, and LTK, which are overexpressed or mutated in a variety of cancer cell types, play key roles in tumor cell growth and survival.\nConcepts: Polygonum cuspidatum Willd. ex Spreng. (Fallopia)\tCLEC13E (MRC2 gene)\tTeebi Shaltout syndrome (Congenital anomaly of face bones)\tactivation of protein kinase activity (Cell Function)\tGilteritinib fumarate (Protein-tyrosine kinase inhibitor)", + "output": "Gilteritinib fumarate (Protein-tyrosine kinase inhibitor)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the Pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version Questionnaire Test Code (Intellectual Product)\tAttribute (Linkage concept)\tUPD1-Activities:Hygiene (UPDRS Questionnaire Question)\tGasoline (Hydrocarbons)\tPrymnesiophyceae (Haptista)", + "output": "Pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version Questionnaire Test Code (Intellectual Product)" + }, + { + "input": "Definition: something described as amniotic constriction rings affecting the legs.\nConcepts: Capillary Sequencing (Nucleic acid sequencing)\thydrencephalus (Hydrocephalic conditions)\tAmniotic constriction rings of legs (Amniotic Bands)\tpale (General signs and symptoms NEC)\tsomatoesthetic sense (Esthesia)", + "output": "Amniotic constriction rings of legs (Amniotic Bands)" + }, + { + "input": "Definition: Intellectual Product described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Severe human suffering: Learned about it.\nConcepts: LEC-5 Standard Version - Severe Human Suffering: Learned (LEC-5 Standard Version Questionnaire Question)\tAre you bothered by shoulder stiffness (Findings-Based Question)\tPNEUMOTACHOMETER (Medical Device)\tscheies syndrome (Mucopolysaccharidosis I)\tcancer-causing gene (Gene or Genome)", + "output": "LEC-5 Standard Version - Severe Human Suffering: Learned (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: something described as organic compounds that contain a ring structure made up of carbon and one or more additional elements such as nitrogen and oxygen.\nConcepts: Death Diagnosis Domain (Idea or Concept)\tOPEN LABEL (Trial Blinding Schema)\tcellubrevin-VAMP4-endobrevin-syntaxin-6 complex location (Cell Component)\tRearrangement of Chromosome 7 (Chromosomal structural abnormalities)\tHeterocyclic Cpds, 1-Ring (Heterocyclic Compounds)", + "output": "Heterocyclic Cpds, 1-Ring (Heterocyclic Compounds)" + }, + { + "input": "Definition: Gas analyzer described as laboratory monitors designed for continuous measuring and display of the carbon dioxide concentration in a closed or semi-closed environment, usually inside of a laboratory device (e.g. incubator, hood). These monitors typically consist of a central unit including electronic circuitry and a digital display, and carbon dioxide sensors located in the interior of the laboratory device.\nConcepts: Group B Streptococcal Infection (Streptococcal Infections)\tMonitors, Laboratory, Carbon Dioxide (Medical Device)\tAbnormality of the pineal gland (Abnormality of the endocrine system)\tNCI Center for Bioinformatics (Health Care Related Organization)\tAccessory Sinus Non-Hodgkin's Lymphoma (Lymphoma, Non-Hodgkin)", + "output": "Monitors, Laboratory, Carbon Dioxide (Medical Device)" + }, + { + "input": "Definition: something described as any bacterial species identified as Morganella morganii that can metabolize lysine.\nConcepts: Ectodermal dysplasia with blindness syndrome (Digestive system hereditary disorder)\tneoplasm/cancer genetics (Science of genetics)\tup-regulation of phytol anabolism (positive regulation of cellular biosynthetic process)\tMORGANELLA MORGANII, LYSINE-POSITIVE (Morganella morganii)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DLD (Medical Device)", + "output": "MORGANELLA MORGANII, LYSINE-POSITIVE (Morganella morganii)" + }, + { + "input": "Definition: Structural disorder of heart described as a non-metastasizing neoplasm that arises from the endocardium.\nConcepts: IVD Panels, Human Genetics, Blood Disorder, Thrombophilia Susceptibility, Del/Dup (Medical Device)\tC-KIT Missense Mutation (C-kit gene mutation)\tBenign tumour of endocardium (Structural disorder of heart)\tCyclocytidine hydrochloride (Organic Chemical)\tAXIN1 Gene (Gene or Genome)", + "output": "Benign tumour of endocardium (Structural disorder of heart)" + }, + { + "input": "Definition: Disease due to Gram-positive bacteria described as an infection of cattle caused by MYCOBACTERIUM BOVIS. It is transmissible to man and other animals.\nConcepts: Recombinant Vaccinia-MUC1-B7 Vaccine (MUC-1 Peptide Vaccine)\tAM-0010 (Pharmacologic Substance)\tPQL13-Hard Ask Doctors/Nurses Questions (Intellectual Product)\tKSHV Inflammatory Cytokine Syndrome (Disease or Syndrome)\tBovine Tuberculosis (Mycobacterium Infections, Nontuberculous)", + "output": "Bovine Tuberculosis (Mycobacterium Infections, Nontuberculous)" + }, + { + "input": "Definition: Needle device described as needles primarily designed for piercing the earlobe that may be used for piercing other body parts (e.g., ear cartilage, nose, navel). These devices typically consist of straight or curved sharp metallic needles with beveled distal tips, diameter gauges in the range of 10 to 20G, and a length of about 50 mm (2 inches); the needles are typically provided sterilized (e.g., using ethylene oxide) for use only in one person. Piercing needles are typically used to provide holes that facilitate placing of jewelry.\nConcepts: Needles, Earlobe/Body Piercing (Manufactured Object)\ttelomerase holoenzyme complex (Cell Component)\tAnkyrin 3 related intellectual disability, sleep disturbance syndrome (Disease or Syndrome)\tEarly childhood stage (Temporal Concept)\tInterleukin-10 Receptor Subunit Alpha, human (Receptor)", + "output": "Needles, Earlobe/Body Piercing (Manufactured Object)" + }, + { + "input": "Definition: something described as the spindle pole body that is formed by spindle pole body duplication, and to which proteins involved in mitotic exit signaling (for example, the septation initiation network in fission yeast) localize.\nConcepts: new SPB (mitotic spindle pole body)\tventral group of the dorsal thalamus (Body Part, Organ, or Organ Component)\tRetractors, Surgical, Maxillofacial, Multipurpose, Self-Retained (Retractors, Surgical, Maxillofacial)\tCopper modified diet (Mineral modified diet)\tExpiratory air trapping (Finding)", + "output": "new SPB (mitotic spindle pole body)" + }, + { + "input": "Definition: something described as v-set and immunoglobulin domain-containing protein 10-like (867 aa, ~92 kDa) is encoded by the human VSIG10L gene. This protein may play a role in cell-cell junction formation.\nConcepts: Management, Continuous Quality (Occupational Activity)\tJTcF Interval, Aggregate (Quantitative Concept)\tEncephalitozoon (Encephalitozoon)\tVSIG10-Like Protein (Binding Proteins)\tFinancial Account (Functional Concept)", + "output": "VSIG10-Like Protein (Binding Proteins)" + }, + { + "input": "Definition: something described as a plant genus of the family POLYGALACEAE that contains onjisaponins, xanthones, pyrones, and benzophenones. The name is similar to other snakeroots such as ASARUM; SANICULA; ARISTOLOCHIA; AGERATINA; and others.\nConcepts: Polygala (Polygalaceae)\tIncreased rate of premature chromosome condensation (Abnormality of chromosome condensation)\tVinyl ether (Pharmacologic Substance)\tTranslational Activation (Genetic Function)\tYeast Budding (Laboratory Procedure)", + "output": "Polygala (Polygalaceae)" + }, + { + "input": "Definition: Finding described as cutaneous melanoma 1.0mm or less in thickness, with or without ulceration.\nConcepts: Detection Kits, Biological Agent, Surface Contamination, Ultraviolet Fluorescence (Detection Kits, Biological Agent)\tSf9 Cell (Cultured Cell Line)\tpT1 Skin Melanoma v6 (Finding)\tflap endonuclease activity (endodeoxyribonuclease activity)\thermaphrodite genitalia morphogenesis (gonad morphogenesis)", + "output": "pT1 Skin Melanoma v6 (Finding)" + }, + { + "input": "Definition: Gene or Genome described as human SPINK1 wild-type allele is located within 5q32 and is approximately 7 kb in length. This allele, which encodes pancreatic secretory trypsin inhibitor protein, is involved in the inhibition of premature trypsin-catalyzed zymogen activation in the pancreas. Certain allelic variants of the SPINK1 gene cause chronic pancreatitis and confer susceptibility to fibrocalculous pancreatic diabetes. Mutated forms of the pancreatic secretory trypsin inhibitor protein are also involved in the development of tropical calcific pancreatitis.\nConcepts: Biological Transport (Metabolism)\tSpink3 (SPINK1 gene)\tAJCC v6 Stage (Disease Stage Qualifier)\tRenal Cell Carcinoma-Symptom Index (Clinical or Research Assessment Questionnaire)\tAcute sleeping sickness (Diseases Caused by Protozoa, Helminths and Other Parasites)", + "output": "Spink3 (SPINK1 gene)" + }, + { + "input": "Definition: something described as this gene plays a role in the regulation of DNA topology.\nConcepts: RECQL5 (Gene or Genome)\tRegistrationCenter.telecomAddress (Telecommunication Address)\tStage 0 Extrahepatic Bile Duct Carcinoma (Extrahepatic Bile Duct Neoplasm)\tGDP-galactose:mannose-1-phosphate guanylyltransferase activity (mannose-phosphate guanylyltransferase activity)\tferrous iron binding (iron binding)", + "output": "RECQL5 (Gene or Genome)" + }, + { + "input": "Definition: Hypersensitivity described as a polysymptomatic condition believed by clinical ecologists to result from immune dysregulation induced by common foods, allergens, and chemicals, resulting in various physical and mental disorders. The medical community has remained largely skeptical of the existence of this \"disease\", given the plethora of symptoms attributed to environmental illness, the lack of reproducible laboratory abnormalities, and the use of unproven therapies to treat the condition.\nConcepts: Concomitant Medication Start Date (Start Date)\tHypersensitivities, Environmental (Hypersensitivity)\tenzyme analyzer (Analyzers, Laboratory, Body Fluid)\tMYCOBACT PARATUBERC (Nontuberculous Mycobacteria)\tup regulation of calcium-dependent ATPase activity (positive regulation of ATPase activity)", + "output": "Hypersensitivities, Environmental (Hypersensitivity)" + }, + { + "input": "Definition: something described as long-chain-fatty-acid-CoA ligase 1 (698 aa, ~78 kDa) is encoded by the human ACSL1 gene. This protein is involved in fatty acid metabolism and transport.\nConcepts: F-Distribution (Continuous Distribution)\tIVD Test Reagent/Kits, Serology, Bacteria, Rickettsia prowazekii, IgM Antibody (Medical Device)\tCocker Spaniel (Mammal)\tcancer genes (Mutation)\tFatty-Acid-Coenzyme A Ligase, Long-Chain 1 (Amino Acid, Peptide, or Protein)", + "output": "Fatty-Acid-Coenzyme A Ligase, Long-Chain 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Ureteral Diseases described as pathological processes involving the URETERS.\nConcepts: URETERAL DIS (Urologic Diseases)\tIntermediate delay of small flap at scalp (Delaying of pedicle graft)\tresponse to beta-carotene (Organism Function)\tright horn of sinus venosus development (anatomical structure development)\tMegakaryoblast (Bone Marrow)", + "output": "URETERAL DIS (Urologic Diseases)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.\nConcepts: negative regulation of kidney development (negative regulation of multicellular organismal process)\tLactoferrins (Lactoglobulins)\tOCI (Intellectual Product)\telectronic pacemaker (Medical Device)\tNurse Executive (Professional or Occupational Group)", + "output": "negative regulation of kidney development (negative regulation of multicellular organismal process)" + }, + { + "input": "Definition: Congenital anomaly of skeletal bone described as a defect in ossification of bone.\nConcepts: Dart Device (Medical Device)\tnegative regulation of protein localization to medial cortex (negative regulation of protein localization to plasma membrane)\tintracellular alkalinization (regulation of intracellular pH)\tcellular response to staurosporine (cellular response to alkaloid)\tDysostoses (Disease or Syndrome)", + "output": "Dysostoses (Disease or Syndrome)" + }, + { + "input": "Definition: Multiple system malformation syndrome described as a multisystem disorder with characteristics of neurogenic arthrogryposis multiplex congenita, renal tubular dysfunction and neonatal cholestasis with low serum gamma-glutamyl transferase activity. The phenotype is variable, even within the same family and cases may go undiagnosed as not all the patients present with the three cardinal features. Mutations in the VPS33B gene (15q26.1) have been found in 75% of ARC families, as well as mutations in the VIPAR gene (C14ORF133), encoding a protein that complexes with VPS33B. Most patients die within the first year of life despite supportive care for metabolic acidosis and cholestasis and those surviving longer show cirrhosis and severe developmental delay.\nConcepts: Bemitradine (Pharmacologic Substance)\tARC (arthrogryposis, renal dysfunction, cholestasis) syndrome (ARTHROGRYPOSIS MULTIPLEX CONGENITA, NEUROGENIC TYPE)\tadrenergic receptor signalling pathway involved in positive regulation of heart rate (adenylate cyclase-activating adrenergic receptor signaling pathway involved in regulation of heart rate)\tPalatum (Head and Neck Part)\texo-1,4-beta-mannobiohydrolase activity (Molecular Function)", + "output": "ARC (arthrogryposis, renal dysfunction, cholestasis) syndrome (ARTHROGRYPOSIS MULTIPLEX CONGENITA, NEUROGENIC TYPE)" + }, + { + "input": "Definition: Intellectual Product described as a patient's estimation of the overall impact of a disease on him or herself at a given time. Typically scored on a numeric rating scale or visual analogue scale.\nConcepts: Carriers, Cleaning, Cotton/Gauze Pad (Carriers, Cleaning)\tamitosis (nuclear division)\tPatient Global Assessment (Self-Report)\tspondylitis; rheumatoid (Seronegative arthritis)\tParabrachialis Laterali, Nucleus (Body Part, Organ, or Organ Component)", + "output": "Patient Global Assessment (Self-Report)" + }, + { + "input": "Definition: something described as at its broadest level, genotype includes the entire genetic constitution of an individual. It is often applied more narrowly to the set of alleles present at one or more specific loci.\nConcepts: Geno (Thesaurus of Psychological Index Terms)\tanti-GnRH vaccine PEP223 (Immunologic Factor)\tPatient Health Questionnaire - 9 Item Questionnaire Test Code (Intellectual Product)\tCSS06-Non-suicidal Self-injurious Behav (C-SSRS Children's Baseline Questionnaire Question)\tCells, Testicular Interstitial (Endocrine Cells)", + "output": "Geno (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual does or did get rattled or flustered.\nConcepts: Irregular septal thickening on pulmonary HRCT (Finding)\tDid you get rattled, upset, or flustered (Clinical or Research Assessment Question)\tAnterior vein of septum pellucidum (Body Part, Organ, or Organ Component)\trenal interstitial fibroblast development (Cell Function)\tRNA capping (RNA Processing, Post-Transcriptional)", + "output": "Did you get rattled, upset, or flustered (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intramural Research Program described as a government-owned, contractor operated cancer research facility located in Frederick, MD. Operated under the direction of the Division of Cancer Biology.\nConcepts: Nucleases, Transcription Activator Like Effector (Amino Acid, Peptide, or Protein)\tgenetic examination (Genetic Techniques)\tbronchiolectasis (Bronchiolar disease)\tFrederick Cancer Research and Development Center (Intramural Research Program)\treplisome progression complex (Cell Component)", + "output": "Frederick Cancer Research and Development Center (Intramural Research Program)" + }, + { + "input": "Definition: something described as any of the four main columns of gray matter, which are located in the spinal cord, and which are composed primarily of neuronal cell bodies and neuroglia.\nConcepts: Spinal Cord Column (Body Part, Organ, or Organ Component)\tSrc/tubulin Inhibitor KX02 (Organic Chemical)\tGrade 4 Intestinal Stoma Leak, CTCAE (Intestinal Stoma Leak, CTCAE)\tbHLHb26 (ID2 gene)\tMucocoele;salivary gland (Deformity)", + "output": "Spinal Cord Column (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: MUSCLE FUNCTIONS AND SYMPTOMS described as a disorder characterized by involuntary and irregular muscle contractions not associated with muscle weakness or atrophy. It most often affects facial muscles. It may be localized or generalized.\nConcepts: PUMA-BCL-xl complex (Cell Component)\tCertificate - death (Intellectual Product)\tIntraretinal fluid (Abnormal retinal morphology)\tChoreas, Morvan (MUSCLE FUNCTIONS AND SYMPTOMS)\tEvaluates cardiac status (Physiologic Responses)", + "output": "Choreas, Morvan (MUSCLE FUNCTIONS AND SYMPTOMS)" + }, + { + "input": "Definition: TRANSCRIPTION FACTOR described as signal transducer and activator of transcription 5B (787 aa, ~90 kDa) is encoded by the human STAT5B gene. This protein plays a role in the metabolism of small molecules, transcriptional regulation and signal transduction.\nConcepts: signal transducer and activator of transcription 5B protein, human (Biologically Active Substance)\tPostterm pregnancy (Abnormality of prenatal development or birth)\tEstimated food variety (Nutrient Intake)\tNew World Monkeys (Anthropoidea)\tHordeum L., 1753 (Cereals)", + "output": "signal transducer and activator of transcription 5B protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: ribonucleoside metabolic process described as the chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule.\nConcepts: Tibial metaphyseal irregularity (Lower-limb metaphyseal irregularity)\tribonucleoside anabolism (nucleoside biosynthetic process)\tmitoguazone dihydrochloride (Polyamine Synthesis Inhibitor)\torthomyxoviridae (Virus)\tFAC005-Trouble Meeting Needs of Family (FACT-B Version 4 Questionnaire Question)", + "output": "ribonucleoside anabolism (nucleoside biosynthetic process)" + }, + { + "input": "Definition: something described as cardiographs designed to make a graphical record of the movements (pulsations) of the precordium over the left ventricular apex of the heart. These cardiographs include a noninvasive transducer (e.g., piezoelectric pressure) that senses the movement (i.e., vibrations) of the soft tissue enclosed in the intercostal space and a graphical recorder that stores the results as an apex cardiogram. Apex cardiographs are typically used to assess left ventricular function by studying the dynamics of myocardial motion under various pathological conditions.\nConcepts: Apex cardiograph (Cardiograph)\tProximal Interphalangeal Joint 4 of the Foot (Body Part, Organ, or Organ Component)\tOropharyngeal (p16-Negative) Carcinoma pTis TNM Finding v8 (Oropharyngeal (p16-Negative) Cancer Pathologic Primary Tumor TNM Finding v8)\tvg/mL (Unit of biological and biochemical measurement)\tVolume Measurement Kits, Foot (Volume Measurement Kits)", + "output": "Apex cardiograph (Cardiograph)" + }, + { + "input": "Definition: Moles per unit time described as a unit of amount of substance flow rate equivalent to the rate at which one thousandth of a mole of substance crosses a given surface or is delivered to a given object or space over a period of time equal to 24 hours.\nConcepts: N-acylglucosamine 2-epimerase activity (racemase and epimerase activity, acting on carbohydrates and derivatives)\tcholesterol analog (steroid analog)\tStatistically Significant (statistical analysis)\tDeoxyribose Uracil (Biologically Active Substance)\tMillimole per 24 Hours (Quantitative Concept)", + "output": "Millimole per 24 Hours (Quantitative Concept)" + }, + { + "input": "Definition: Organic Chemical described as the hyrochloride salt form of amorolfine, a morpholine antifungal agent. Amorolfine inhibits delta-14-reductase and delta-7,8-isomerase, which depletes ergosterol and causes ignosterol to accumulate in the fungal cytoplasmic cell membrane.\nConcepts: type 2 cysteinyl leukotriene receptor binding (Molecular Function)\ttransition metal transport (metal ion transport)\tmitotic spindle positioning and orientation (Cell Function)\tamorolfine hydrochloride (A [Preparations])\tConjunctiva, Bulbar (Body Part, Organ, or Organ Component)", + "output": "amorolfine hydrochloride (A [Preparations])" + }, + { + "input": "Definition: ELK4 gene described as human ELK4 wild-type allele is located in the vicinity of 1q32 and is approximately 25 kb in length. This allele, which encodes ETS domain-containing protein Elk-4, plays a role in the modulation of transcription. A chromosomal aberration involving this gene and the SLC45A3 gene may be associated with prostate cancer.\nConcepts: kidney tubule (Kidney)\tELK4, ETS-Domain Protein (SRF Accessory Protein 1) wt Allele (Gene or Genome)\tTumor Laterality Right (Finding)\tALPHA-GLOBULIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tCulture Medium, Conditioned (Indicator, Reagent, or Diagnostic Aid)", + "output": "ELK4, ETS-Domain Protein (SRF Accessory Protein 1) wt Allele (Gene or Genome)" + }, + { + "input": "Definition: UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale '99 - Please indicate the most accurate current level of subject's independence (only increments of 5 are acceptable).\nConcepts: schools (Schools & Institutions)\tMNSI - Feet Too Sensitive to Touch (Intellectual Product)\tUHDR1-Current Level Subject Independence (UHDRS 1999 Version Clinical Classification Question)\tDioxins and Dioxin like Compounds (Hazardous or Poisonous Substance)\t6-acetylglucose deacetylase activity (Molecular Function)", + "output": "UHDR1-Current Level Subject Independence (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: Temporal relationship described as a noteworthy happening that is distinctive in a series of related events.\nConcepts: Lugano Classification Stage III Adult Non-Hodgkin Lymphoma AJCC v8 (Neoplastic Process)\tsteroid,hydrogen-donor:oxygen oxidoreductase (Molecular Function)\ttaxonomyRankCode (Code)\tEpisodes (Episodicity)\tSoftware, Device Programming/Testing, Implantable Infusion Pump (Intellectual Product)", + "output": "Episodes (Episodicity)" + }, + { + "input": "Definition: something described as the total process by which organisms produce offspring.\nConcepts: procreation (Knowledge level: sexual functioning)\tsocial (General Qualifier)\tXanthomatosis (Lipid metabolism and deposit disorders NEC)\tAbnormal proportion of naive B cells (Finding)\tCISNET (Consortium or Network)", + "output": "procreation (Knowledge level: sexual functioning)" + }, + { + "input": "Definition: something described as a protein complex that consists of an alpha9-beta1 integrin complex bound to osteopontin.\nConcepts: 3-(2,4-dihydroxy-5-isopropylphenyl)-4-(1-methylindol-5-yl)-5-hydroxy-4h-1,2,4-triazole 3h-1,2,4-triazol-3-one (HSP90 Inhibitor)\talpha9-beta1 integrin-osteopontin complex (plasma membrane protein complex)\tMycosis fungoides/Sezary syndrome NOS (Neoplastic Process)\tEndopeptidase Clp (Hydrolase)\t2-hydroxybiphenyl 3-monooxygenase activity (Molecular Function)", + "output": "alpha9-beta1 integrin-osteopontin complex (plasma membrane protein complex)" + }, + { + "input": "Definition: Abnormality of the internal auditory canal described as reduction in diameter of the internal auditory canal.\nConcepts: Abnormality of the submandibular glands (Abnormal salivary gland morphology)\tEducation about use of covering device (Educational process of instructing)\tNarrow internal auditory canal (Finding)\tLeber Abiotrophy Gene Panel Reagents (IVD Panels, Human Genetics, Eye Disorder)\tRound Epithelial Cell Count (Epithelial cell count)", + "output": "Narrow internal auditory canal (Finding)" + }, + { + "input": "Definition: Non-Neoplastic Eye Disorder described as corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.\nConcepts: Cervical Cancer pN0 TNM Finding v7 (Finding)\tGrade 2 Generalized muscle weakness (Finding)\tDry Eye (Syndrome)\tPRE binding (RNA Binding)\trosae rugosae/mei gui hua (Plant)", + "output": "Dry Eye (Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (November 2002) Long Last 7 Days Telephone Format (IPAQ Long Last 7 Days Telephone Format Version) How much time did you usually spend on one of those days traveling in a car, bus, train or other kind of motor vehicle?: Minutes per day.\nConcepts: Comprehensive Microcephaly Gene Deletion/Duplication Reagents (IVD Panels, Human Genetics, Encephalopathy, Brain Malformation, Microcephaly)\tIPAQ Long Last 7 Days Telephone Format Version - Traveling Minutes per Day (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\t12p13.2 (Chromosome band)\tfarnesyl diphosphate catabolism (farnesyl diphosphate metabolic process)\tprogramming language (Intellectual Product)", + "output": "IPAQ Long Last 7 Days Telephone Format Version - Traveling Minutes per Day (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor described as catalysis of the reaction: NADP + a reduced coenzyme F420 <=> NADPH + H+ + an oxidized coenzyme F420.\nConcepts: response to boron (response to chemical)\tGCL - Globoid cell leucodystrophy (Autosomal recessive hereditary disorder)\tMaternally inherited cardiomyopathy and deafness (Hypertrophic Cardiomyopathy)\t8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity (Molecular Function)\tNNAL-Glucuronide (Carcinogenic Nitrosamine)", + "output": "8-hydroxy-5-deazaflavin:NADPH oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: something described as stage IVC includes: Any T, Any N, M1. M1: Distant metastasis.\nConcepts: chlororespiration (respiratory electron transport chain process)\tStage IVC Laryngeal Cancer (Stage IV Laryngeal Cancer AJCC v7)\tBlood Coagulation Disorders, Inherited (Genetic Diseases, Inborn)\tindoleacetic acid formation via tryptophan (indoleacetic acid biosynthetic process)\tArg (primary aminoacid)", + "output": "Stage IVC Laryngeal Cancer (Stage IV Laryngeal Cancer AJCC v7)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solutions, creams, or gels designed for vaginal application. These solutions and creams are applied inside the vagina to produce a local effect (e.g., lubricating, germicidal) or to create a physical barrier on the surface of the cavity; some liquid products can be applied as sprays. Vaginal topical products are frequently made from a variety of plant materials and may also include some additives for particular purposes. Some products are used for hygiene, lubrication, acidity (i.e., pH) control, and to treat small ulcers. Products that combine the creation of a physical barrier (e.g., a film) and germicidal properties are also available.\nConcepts: Topical Solution/Cream/Gels, Vaginal (Topical Solution/Cream/Gels)\tlysophagy (selective autophagy)\tGRADE X (Intellectual Product)\t4-HPR (Organic Chemical)\tRSSS0104 (RAND Social Support Survey Questionnaire Question)", + "output": "Topical Solution/Cream/Gels, Vaginal (Topical Solution/Cream/Gels)" + }, + { + "input": "Definition: SLC46A1 gene described as human SLC46A1 wild-type allele is located in the vicinity of 17q11.2 and is approximately 13 kb in length. This allele, which encodes proton-coupled folate transporter protein, is involved in transport of both folate and antifolate across the plasma membrane, and heme transport in duodenal enterocytes. Mutations in this gene are associated with hereditary folate malabsorption.\nConcepts: G21 (Gene or Genome)\tZero (Whole Number)\tLocus ID (Intellectual Product)\tsmelling (Sensory Process)\tBMS275183 (Taxane-Pocket Binding Agent)", + "output": "G21 (Gene or Genome)" + }, + { + "input": "Definition: Rickettsia, typhus group described as a species of aerobic, Gram negative, rod and cocci shaped bacteria assigned to the phylum Proteobacteria. This species is obligately intracellular, motile and transmitted to humans by a tick or flea host. R. typhi is a pathogen that causes murine typhus.\nConcepts: Aching (Finding of sensory dimension of pain)\tRickettsia mooseri (Rickettsia, typhus group)\tAbnormality of masseter muscle (Abnormality of masticatory muscle)\tFat adherence syndrome (Eye and ear procedural complications)\tdata listing (List)", + "output": "Rickettsia mooseri (Rickettsia, typhus group)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally available human C-C chemokine receptor type 2 (CCR2) antagonist, with potential immunomodulating and antineoplastic activities. Upon oral administration, CCR2 antagonist CCX872-B specifically binds to CCR2 and prevents the binding to its cognate endothelium-derived chemokine ligand CCL2 (monocyte chemoattractant protein-1 or MCP1). This may result in the inhibition of both CCR2 activation and CCR2-mediated signal transduction, which may inhibit inflammatory processes, angiogenesis, tumor cell migration, and tumor cell proliferation. The G-protein coupled receptor CCR2 is expressed on the surface of monocytes and macrophages, and stimulates their migration and infiltration; it plays a key role in inflammation. CCR2 is overexpressed in certain cancer cell types, where it is involved in angiogenesis, tumor cell migration and proliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C120302\" active clinical trials using this agent.\nConcepts: heart jogging (embryonic heart tube morphogenesis)\tMeningioma of Epidural Spinal Canal (Neoplastic Process)\tEosinophilic pneumonia, NOS (PULMONARY DISORDERS: GENERAL)\tdTTP biosynthetic process (pyrimidine deoxyribonucleoside triphosphate biosynthetic process)\tCCR2 Antagonist CCX872-B (Pharmacologic Substance)", + "output": "CCR2 Antagonist CCX872-B (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside.\nConcepts: positive regulation of translation in response to stress (positive regulation of protein biosynthesis)\tPOG Neuroblastoma Stage DS (POG Neuroblastoma Stage D)\tdeoxyinosine degradation (deoxyinosine metabolic process)\tInfiltrating Apocrine Carcinoma of Breast (Apocrine breast carcinoma)\tADM (Amino Acid, Peptide, or Protein)", + "output": "deoxyinosine degradation (deoxyinosine metabolic process)" + }, + { + "input": "Definition: something described as a chronic form of sinusitis.\nConcepts: Antigens, HTLV-BLV (Immunologic Factor)\tZIC2 (Gene or Genome)\tregulation of monocyte chemotaxis (regulation of leukocyte chemotaxis)\tchronic sinus infection (Paranasal Sinus Disorder)\tHair thinning (Dermatologic disorders)", + "output": "chronic sinus infection (Paranasal Sinus Disorder)" + }, + { + "input": "Definition: Immunologic Factor described as substances of archaeal origin that have antigenic activity.\nConcepts: Atlantic Ocean (Geographic Area)\tEndometriosis, myometrium (Uterine Corpus Non-Neoplastic Disorder)\tArchaeal Antigens (Antigens)\t953-954 HALLUCINATIONS (False perception)\tcervical deep lymph nodes (Structure of deep lymph node)", + "output": "Archaeal Antigens (Antigens)" + }, + { + "input": "Definition: Conjunctivitis, CTCAE described as best corrected visual acuity of 20/200 or worse in the affected eye\nConcepts: Low-grade fibromyxoid sarcoma (Neoplasms, Unknown Primary)\tGrade 4 Conjunctivitis, CTCAE (Conjunctivitis, CTCAE)\tPadDrugForm (Biomedical or Dental Material)\tPODCI274 (Intellectual Product)\tHave Fever (Findings-Based Question)", + "output": "Grade 4 Conjunctivitis, CTCAE (Conjunctivitis, CTCAE)" + }, + { + "input": "Definition: Molecular Function described as the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC).\nConcepts: Azintuxizumab vedotin (Pharmacologic Substance)\tReduced Folate Carrier Protein (Carrier Proteins)\tdown regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment (negative regulation of cardiac muscle cell differentiation)\tMIR516A2 gene (Gene or Genome)\tWnt receptor signaling pathway, calcium modulating pathway (Molecular Function)", + "output": "Wnt receptor signaling pathway, calcium modulating pathway (Molecular Function)" + }, + { + "input": "Definition: beta-Chemokines described as chemokines that are chemoattractants for monocytes. These CC chemokines (cysteines adjacent) number at least three including CHEMOKINE CCL2.\nConcepts: Fletcher-suit Brachytherapy (Therapeutic or Preventive Procedure)\tMonocyte Chemotactic Proteins (Immunologic Factor)\tInvasive Lobular Breast Carcinoma, Pleomorphic Variant (Neoplastic Process)\tEndoscopic examination of colon (Endoscopy)\tAmpulla of Vater Hepatoid Adenocarcinoma (Hepatoid adenocarcinoma)", + "output": "Monocyte Chemotactic Proteins (Immunologic Factor)" + }, + { + "input": "Definition: regulation of non-canonical Wnt signaling pathway described as any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway.\nConcepts: Panuveitis (Rare Non-Neoplastic Disorder)\tregulation of Wnt receptor signalling pathway, planar cell polarity pathway (regulation of establishment of planar polarity)\tCHROMOSOME 3q29 DELETION SYNDROME (Deletion of part of autosome)\tStage I Hepatocellular Cancer (Hepatocellular Carcinoma by AJCC v6 Stage)\tMIR208A Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "regulation of Wnt receptor signalling pathway, planar cell polarity pathway (regulation of establishment of planar polarity)" + }, + { + "input": "Definition: chlorobenzene described as an antibacterial and antifungal agent for topical use, mostly used now in veterinary medicine.\nConcepts: Membrane Associated Ring Finger 9 (Enzyme)\tdisease (or disorder); nerve, ulnar (Disorder of soft tissue)\tJuvenile RA (Skeletal)\tabsence of one kidney congenital (Urogenital Abnormalities)\tbis(2-hydroxy-5-chlorophenyl)sulfide (polyphenols)", + "output": "bis(2-hydroxy-5-chlorophenyl)sulfide (polyphenols)" + }, + { + "input": "Definition: Health Promotion described as recognition of normal function and well-being\nConcepts: Health awareness (Health Promotion)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question (Clinical or Research Assessment Question)\tRefractory Childhood Hodgkin Lymphoma (Refractory Hodgkin Lymphoma)\tKarnofsky Performance Status Scale Questionnaire Test Code (Intellectual Product)\tAntenna (Device Component or Accessory)", + "output": "Health awareness (Health Promotion)" + }, + { + "input": "Definition: dihydropyridine described as a calcium channel blocker with marked vasodilator action. It is an effective antihypertensive agent and differs from other calcium channel blockers in that it does not reduce glomerular filtration rate and is mildly natriuretic, rather than sodium retentive.\nConcepts: Nitrendipinum (Dihydropyridine derivative)\tH3 Gene (Gene or Genome)\tIshak Score 2 (Ishak Score)\tCongenital cataract with intellectual disability and anal atresia and urinary defect syndrome (Mental Retardation)\tContraceptive, Oral (Type of drug)", + "output": "Nitrendipinum (Dihydropyridine derivative)" + }, + { + "input": "Definition: Invasive carcinoma of breast described as an invasive adenocarcinoma of the breast characterized by the presence of islands of small and uniform cells, surrounded by large amounts of mucin. Pure mucinous breast carcinomas generally have a favorable prognosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9131\" active clinical trials using this agent.\nConcepts: Clostridium botulinum Toxin B6 (Amino Acid, Peptide, or Protein)\tMucinous Carcinoma of Breast (Breast Carcinoma)\tRattlesnake Fibroma (Experimental Organism Neoplasm by Organism)\tBRD4 Interacting Chromatin Remodeling Complex Associated Protein (Biologically Active Substance)\tThird (General adjectival modifier)", + "output": "Mucinous Carcinoma of Breast (Breast Carcinoma)" + }, + { + "input": "Definition: Body cavity endoscope described as ENDOSCOPES for examining the abdominal and pelvic organs in the peritoneal cavity.\nConcepts: peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity (Molecular Function)\tFamilial haemolytic uraemic syndrome (Congenital hemolytic uremic syndrome)\tRisk for disturbed maternal-fetal dyad (Reproduction)\tERBB4:ERBB2 complex (plasma membrane signaling receptor complex)\tPeritoneal Cavity Endoscopes (Surgical Equipment)", + "output": "Peritoneal Cavity Endoscopes (Surgical Equipment)" + }, + { + "input": "Definition: Structure of right side of abdomen described as the ureter connecting the right kidney to the bladder.\nConcepts: FAC06148 (Intellectual Product)\tRP11-544M22.5 (USF1 gene)\tCevane Alkaloids (Organic Chemical)\tright ureter (Body Part, Organ, or Organ Component)\tisosulfamerazine (Long-acting sulfonamides)", + "output": "right ureter (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4).\nConcepts: peptidyl-allysine oxidation to 2-aminoadipic acid (Molecular Function)\tglycolate reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\thistone acetyltransferase activity (Molecular Function)\tirNE (Immune-related Response Evaluation Criteria In Solid Tumors)\tTorsade de pointes, shock-associated conditions (Classification)", + "output": "histone acetyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Dog family described as a large terrier with a harsh wiry coat, a long flat head, and a deep chest. The coat is usually tan with black (or dark grizzle) markings. The average height range is 22-24 inches and the average weight range is 40-65 pounds.\nConcepts: Small epiphyses (Limb structure)\tPerformed Medical Condition Result (Finding)\tEpithelial tissue (integumentary system: general terms)\tmercurius iodatus ruber/merc (Inorganic Chemical)\tAiredale terrier (Canis familiaris)", + "output": "Airedale terrier (Canis familiaris)" + }, + { + "input": "Definition: P [Preparations] described as a hydrazine derivative and a potent non-selective monoamine oxidase (MAO) inhibitor with anxiolytic and antidepressant properties. Phenelzine sulfate irreversibly binds to MAO, thereby blocking the oxidative deamination of monoamines resulting in an increased concentration of biogenic amines and a concurrent decrease in catabolism of monoamine neurotransmitters, norepinephrine and serotonin, in the brain. In addition, through its primary metabolite phenylethylidenehyrazine (PEH), phenelzine causes elevated GABA levels in the caudate-putamen and nucleus accumbens thereby exerting its anxiolytic effects. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47668\" active clinical trials using this agent.\nConcepts: Advanced Ureter Urothelial Carcinoma (Neoplastic Process)\tDrug-Eluting Stents (Stent, device)\tStage I Gastric Neuroendocrine Tumor AJCC v8 (Neoplastic Process)\t2-Phenylethylhydrazine Hydrogen Sulphate (P [Preparations])\tgerm-cell nucleus (Cell Component)", + "output": "2-Phenylethylhydrazine Hydrogen Sulphate (P [Preparations])" + }, + { + "input": "Definition: something described as test codes of questionnaire questions associated with the St. George's Respiratory Questionnaire Past 3 Months Version (SGRQ Past 3 Months Version) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: 4: 123735485-123730230 (Chromosome 4 Physical Location)\tN1bII (Finding)\tSmoothened, Seven Transmembrane Spanning Receptor Gene (SMO gene)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, Human T-Cell Lymphotropic Virus-I (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, Human T-Cell Lymphotropic Virus)\tSGRQ01TC (Intellectual Product)", + "output": "SGRQ01TC (Intellectual Product)" + }, + { + "input": "Definition: something described as aplasia of the stapes.\nConcepts: Extraction Purification (Purifying)\tFlexural lichenification (Disease or Syndrome)\tStapes absent (Abnormality of the stapes)\tdown regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)\tpyruvate membrane transport (Molecular Function)", + "output": "Stapes absent (Abnormality of the stapes)" + }, + { + "input": "Definition: Chromosomes described as the sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males.\nConcepts: Shortening of all the middle bones of the toes (Short middle phalanx of toe)\tguanidinodeoxy-scyllo-inositol-4-phosphatase activity (Molecular Function)\tchromosome male sex (NUCLEUS AND ASSOCIATED STRUCTURES)\tFAC01716 (FACT-LEU Version 4 Questionnaire Question)\tcookbooks (Intellectual Product)", + "output": "chromosome male sex (NUCLEUS AND ASSOCIATED STRUCTURES)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes.\nConcepts: Koserella (Yokenella)\tAbnormal myeloid leukocyte morphology (White blood cell abnormality)\tHM95573 (Organic Chemical)\tdeoxyadenosine synthesis (Molecular Function)\tVDR binding (nuclear hormone receptor binding)", + "output": "VDR binding (nuclear hormone receptor binding)" + }, + { + "input": "Definition: Cephalosporins described as the monohydrate form of cephradine, a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephradine monohydrate binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.\nConcepts: Bleomycinamide, N1-(3-((1-phenylethyl)amino)propyl)-, (S)- (bleomycin)\tQuercetin (Vitamin)\tChild care (Career Areas)\tCephradine Monohydrate (Cephalosporins)\tHairy Cell Count (leukocyte morphology: hairy cells)", + "output": "Cephradine Monohydrate (Cephalosporins)" + }, + { + "input": "Definition: Oral lesion described as inflammation of the oral mucosa due to local or systemic factors.\nConcepts: Intervertebral foramen (Body conduit)\tBenign neoplasm of lymph nodes (Benign neoplasm of other and unspecified sites)\tStomatitis, NOS (Non-Neoplastic Oral Cavity Disorder)\tBone Surface (Peripheral) Osteosarcoma (Primary Bone Osteosarcoma)\tcardiac pacemaker cell fate commitment (Cell Function)", + "output": "Stomatitis, NOS (Non-Neoplastic Oral Cavity Disorder)" + }, + { + "input": "Definition: Squamous non-small cell lung cancer described as a morphologic variant of squamous cell lung carcinoma characterized by the presence of clear cells.\nConcepts: Squamous Cell Lung Carcinoma, Clear Cell Variant (Squamous cell carcinoma, keratinizing)\tDefinitely Agree (Clinical or Research Assessment Answer)\talpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity (phosphotransferase activity, for other substituted phosphate groups)\tRegulation of Splicing through Sam68 (Molecular Function)\tIntraoperative Endoscopy (Endoscopy)", + "output": "Squamous Cell Lung Carcinoma, Clear Cell Variant (Squamous cell carcinoma, keratinizing)" + }, + { + "input": "Definition: something described as this gene is involved in both signaling and protein folding.\nConcepts: Cardiac conducting system structure (Myocardium)\tregulation of signal transduction by receptor internalization (Molecular Function)\tAnser anser anser (Family Anatidae)\tFK506-BINDING PROTEIN 1A (Isomerase Gene)\tBlock Design (Intellectual Product)", + "output": "FK506-BINDING PROTEIN 1A (Isomerase Gene)" + }, + { + "input": "Definition: Neoplastic Process described as a rare, non-invasive, localized or multifocal neoplasm that arises from the pleura. It is characterized by the presence of papillae with myxoid fibrovascular cores, lined by a single layer of mesothelial cells. The clinical course is usually indolent.\nConcepts: allogeneic GM-CSF-secreting tumor vaccine PANC 6.03 pcDNA-1/GM-Neo (Cell)\tFiber Optic Device (Manufactured Object)\tPleural Well Differentiated Papillary Mesothelioma (Neoplastic Process)\tHillmen Color Chart (Ophthalmic examination and evaluation)\tSkin abrasions (Skin lesion)", + "output": "Pleural Well Differentiated Papillary Mesothelioma (Neoplastic Process)" + }, + { + "input": "Definition: New Myocardial Infarction by ECG Finding described as an electrocardiographic finding of pathologic Q waves in leads I and aVL, which is suggestive of myocardial infarction of the high lateral wall of the left ventricle and which is new compared to prior ECGs.\nConcepts: negative regulation of type B pancreatic cell development (Cell Function)\tCII-4 c.34G>A (Cell or Molecular Dysfunction)\tOrgano-Metallic, Phosphorus, Boron Derivatives (Organic Chemical)\tNew High Lateral Myocardial Infarction by EKG Finding (Finding)\tnegative regulation of lipoprotein transport (regulation of lipoprotein transport)", + "output": "New High Lateral Myocardial Infarction by EKG Finding (Finding)" + }, + { + "input": "Definition: something described as the anhydrous form of tezacitabine, a synthetic pyrimidine nucleoside analogue with potential antineoplastic activity. Phosphorylated by cellular kinases, tezacitabine is converted into its active diphosphate and triphosphate metabolites. Tezacitabine diphosphate binds to and irreversibly inhibits the activity of the enzyme ribonucleotide reductase (RNR), which may result in the inhibition of DNA synthesis in tumor cells and eventually tumor cell apoptosis. Tezacitabine triphosphate acts as a substrate for DNA polymerase, thereby further inhibiting DNA replication. RNR catalyzes the conversion of ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates, a necessary step for DNA synthesis, and is overexpressed in many tumor cell types.\nConcepts: Melatonin Secretion Process (Organ or Tissue Function)\tPost Office Box (Geographic Area)\thistrelinum (Gonadotropin Releasing Hormone Receptor Agonist [EPC])\tAVL01-List B Recall Word 14 (Intellectual Product)\tTezacitabine Anhydrous (pyrimidine analog)", + "output": "Tezacitabine Anhydrous (pyrimidine analog)" + }, + { + "input": "Definition: Finding described as vaginal cancer with no evidence of primary tumor.\nConcepts: Ergoline-8-methanol, 10-methoxy-1,6-dimethyl-, 5-bromo-3-pyridinecarboxylate (ester), (8beta)- (Ergot alkaloid peripheral vasodilators)\tLysine-specific Demethylase 1 Inhibitor CC-90011 (Antineoplastic Enzyme Inhibitor)\tEmtricitabine + tenofovir disoproxil fumarate (Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors)\tSeminal Vesicle Mammary-Type Myofibroblastoma (Benign tumor of seminal vesicle)\tVaginal Cancer pT0 TNM Finding v8 (Finding)", + "output": "Vaginal Cancer pT0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Mandatory Indicator described as specifies whether the modifications contained in the study protocol version must be applied to all sites and subjects or study subjects that want to continue participating in the study. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: Syringes, Plunger, Hypodermic, Protective (Syringes, Plunger, Protective)\tStudyProtocolVersion.mandatoryIndicator (Qualitative Concept)\tAminophosphonate Metabolism Pathway (Molecular Function)\tPeriosteal Desmoid Tumor (Non-Neoplastic Soft Tissue Disorder)\tSeverely compromised dentate occlusal scheme (Severely compromised occlusal scheme)", + "output": "StudyProtocolVersion.mandatoryIndicator (Qualitative Concept)" + }, + { + "input": "Definition: Prostate specific antigen measurement described as the determination of the amount of free prostate specific antigen in a biological sample.\nConcepts: Cesky Terrier (Mammal)\tIVD Test Reagent/Kits, Immunoassay, Anemia Test, Ferritin (IVD Test Reagent/Kits, Immunoassay, Anemia Test)\tImmunoglobulin Heavy Variable 3-21 (Immunoproteins)\tAs Collected Indicator (Indicator)\tProstate Specific Antigen, Free (Cell marker analysis)", + "output": "Prostate Specific Antigen, Free (Cell marker analysis)" + }, + { + "input": "Definition: something described as the protocol defined period of time in a study that begins immediately after the birth of the subject.\nConcepts: chloride ea.tst (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tPOSTNATAL (Temporal Concept)\tBEBQ01-Baby Has a Big Appetite (Intellectual Product)\tMicrovascular Circulations (Organ or Tissue Function)\tGeneralized bone demineralization (Finding)", + "output": "POSTNATAL (Temporal Concept)" + }, + { + "input": "Definition: something described as an adverse event in a newborn characterized by reduced number of stools or hard stools; apparent discomfort; minor care changes indicated.\nConcepts: Tritium (Inorganic Chemicals)\tGrade 2 Neonatal Constipation, Adverse Event (Finding)\tDehydroisoandrosterone Glucopyranuronoside (Organic Chemical)\tmultisubtype natural human leukocyte interferon alpha (Pharmacologic Substance)\tAs Good as Others (Finding)", + "output": "Grade 2 Neonatal Constipation, Adverse Event (Finding)" + }, + { + "input": "Definition: something described as characterised by spillage of melanin from the basal keratinocytes into the underlying connective tissue of the lips.\nConcepts: Labial melanin incontinence (Skin Pigmentation Disorder)\tCytoplasmic granules (Membranous cytoplasmic organelle)\tcarbon dioxide transmembrane transporter activity (Molecular Function)\tup-regulation of eukaryotic chromosome condensation (regulation of chromosome condensation)\tnightshade family (Solanales)", + "output": "Labial melanin incontinence (Skin Pigmentation Disorder)" + }, + { + "input": "Definition: Bladder Cancer Pathologic Primary Tumor TNM Finding v6 described as bladder cancer with invasion into the deep muscle layer.\nConcepts: Temporal Qualifier (Qualifier)\tNnspcfd HCPCS II environment (Health Care Activity)\tpT2b Carcinoma of the Bladder TNM Finding v6 (Finding)\tLEFT VENTRICULAR PACING MALFUNCTION (Pacing Problem)\tUS (File)", + "output": "pT2b Carcinoma of the Bladder TNM Finding v6 (Finding)" + }, + { + "input": "Definition: Breast adenoma described as a rare, benign and well circumscribed neoplasm that arises from the breast. It is characterized by the proliferation of epithelial cells with extensive apocrine metaplasia.\nConcepts: Transportation and Material Moving Occupations (Miscellaneous Occupation)\tcutaneous lupus erythematosus (Autoimmune skin disease)\tClinical Stage IIA Gastric Carcinoma AJCC v8 (Clinical Stage II Gastric Cancer AJCC v8)\tlocus control region (Genetic Loci)\tapocrine; adenoma, breast (Breast adenoma)", + "output": "apocrine; adenoma, breast (Breast adenoma)" + }, + { + "input": "Definition: something described as system of words used in a particular discipline; examples include legal terminology, chemical terminology, medical terminology, etc.\nConcepts: KIT (Potency Unit)\tnomenclature (Terminology Entity)\tinvadopodium disassembly (Cell Function)\tSynchrotrons (Instrument - device)\tUHDR126A (UHDRS 1999 Version Clinical Classification Question)", + "output": "nomenclature (Terminology Entity)" + }, + { + "input": "Definition: something described as any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine.\nConcepts: Congenital Testicular Failure (Disease or Syndrome)\tpositive regulation of the force of heart contraction by chemical signal (regulation of the force of heart contraction by chemical signal)\tGrade 4 Esophageal hemorrhage (Finding)\tspinal cord neurofibroma (neurofibroma)\texopeptidase (Peptide Hydrolases)", + "output": "positive regulation of the force of heart contraction by chemical signal (regulation of the force of heart contraction by chemical signal)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the secretory proteins of the seminal vesicles are proteins and enzymes that are important in the rapid clotting of the ejaculate. The major clotting protein is seminal vesicle-specific antigen. Many of these seminal vesicle proteins are under androgen regulation, and are substrates for the prostatic enzymes, such as the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.\nConcepts: T cell dysfunction (Abnormality of T cell physiology)\tdGMP metabolism (purine deoxyribonucleoside monophosphate metabolic process)\tFracture of Long Bone Related to Birth Trauma (Finding)\tclose set eyes (Eye)\tVesicle Proteins, Seminal (Seminal Plasma Proteins)", + "output": "Vesicle Proteins, Seminal (Seminal Plasma Proteins)" + }, + { + "input": "Definition: Primitive reflexes described as a type of primitive reflex that is elicited by repetitive tapping on the forehead. Normal subjects usually blink in response to the first several taps, but if blinking persists, the response is abnormal and considered to be a sign of frontal release. Persistent blinking is also known as Myerson's sign.\nConcepts: Glabellar reflex (Finding)\tCHSF2-Strangers Spoke with Last Month (CHART-SF Paper Version Questionnaire Question)\tUrinary Tract Infectious Disease (Other disorders of urethra and urinary tract)\tCongenital spastic paralysis (Spastic cerebral palsy)\tAutosomal recessive spastic paraplegia type 23 (Disease or Syndrome)", + "output": "Glabellar reflex (Finding)" + }, + { + "input": "Definition: something described as a genus of filarial nematodes. Various immature species have been found to infect the eyes or subcutaneous tissue in humans.\nConcepts: Chromosomal Triplication (Chromosomal Duplication)\t3,5,7,4'-tetrahydroxy-3',5'-dimethoxyflavylium (Organic Chemical)\tregulation of viral envelope fusion with host cell membrane (regulation of viral entry into host cell)\tregion 3 (Body Part, Organ, or Organ Component)\tDirofilarias (Eukaryote)", + "output": "Dirofilarias (Eukaryote)" + }, + { + "input": "Definition: something described as an injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration, the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed on a wide range of primary and metastatic human cancers.\nConcepts: Velcade/Doxil/Dexamethasone (Therapeutic or Preventive Procedure)\tresponse to vitamin A acid (response to lipid)\tfolate receptor-targeted tubulysin conjugate EC1456 (Pharmacologic Substance)\tDental Materials, Impression, Rubber-Based (Dental impression material)\tremission/regression (Pathologic Processes)", + "output": "folate receptor-targeted tubulysin conjugate EC1456 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as an indication as to whether the pulse sequence is a saturation recovery sequence.\nConcepts: CO2 (Research Activity)\tpositive regulation of antiviral response by host (regulation of defense response to virus by host)\tLytic defects of the humerus (Abnormal humerus morphology)\tSaturation Recovery Indicator (Indicator)\tferrum aceticum/iron acetate (Pharmacologic Substance)", + "output": "Saturation Recovery Indicator (Indicator)" + }, + { + "input": "Definition: Intellectual Product described as hamilton Depression Rating Scale 24 Item - Anxiety - psychic.\nConcepts: Physical properties (Property or Attribute)\tHAMD 24 - Anxiety, Psychic (Intellectual Product)\tViscera Response (Global Response)\tHLADPB1 (Immunologic Tests)\tElectrosurgical Units, Monopolar/Bipolar (Medical Device)", + "output": "HAMD 24 - Anxiety, Psychic (Intellectual Product)" + }, + { + "input": "Definition: something described as the determination of the ratio of potassium compared to creatinine present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Malignant Ovarian Cyst (Ovarian neoplasms malignant)\tUse For (NCI Thesaurus Property)\tGrade 1 Neonatal Respiratory Distress Syndrome (Neonatal Respiratory Distress Syndrome, Adverse Event)\tLocally Advanced Gastrointestinal System Neuroendocrine Carcinoma (Metastatic Digestive System Neuroendocrine Carcinoma)\tPotassium/Creatinine (Laboratory Procedure)", + "output": "Potassium/Creatinine (Laboratory Procedure)" + }, + { + "input": "Definition: Food described as a property indicating a class of food components that contribute energy to the diet and that are typically consumed in multi-gram amounts.\nConcepts: reflex (Motor Manifestations)\tLeiomyoma of the Extrahepatic Bile Duct (Benign neoplasm of extrahepatic bile ducts)\tselenol Se-methyltransferase activity (Molecular Function)\tMacronutrient (Food)\tVascular closure device (Device Labeled for Single Use)", + "output": "Macronutrient (Food)" + }, + { + "input": "Definition: Non-site specific bone disorders congenital described as autosomal dominant collagen disease resulting from defective biosynthesis of collagen type I and characterized by brittle, osteoporotic, and easily fractured bones; may also present with blue sclerae, loose joints, and imperfect dentin formation.\nConcepts: Corethamid (Central Nervous System Stimulants)\tesomeprazole magnesium (Monoamine Oxidase Inhibitors)\tbrittle bone syndrome (Musculoskeletal and connective tissue disorders)\tCD19LY (Laboratory Procedure)\tKrause-Van Schooneveld-Kivlin Syndrome (Syndrome)", + "output": "brittle bone syndrome (Musculoskeletal and connective tissue disorders)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as trichinella spiralis serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Trichinella spiralis in serum. The identification aids in the diagnosis of trichinosis caused by parasitic roundworms belonging to the genus Trichinella and provides epidemiological information on trichinosis. Trichinosis is caused by ingestion of undercooked, infested meat, especially pork, and characterized by fever, muscle weakness, and diarrhea.\nConcepts: 1q43 (Chromosome band)\tAdvanced Digestive System Carcinoma (Metastatic Digestive System Carcinoma)\tANTIGEN, BENTONITE FLOCCULATION, TRICHINELLA SPIRALIS (Indicator, Reagent, or Diagnostic Aid)\tTAFII100 (Gene or Genome)\tKetose-Aldose Isomerases (Enzyme)", + "output": "ANTIGEN, BENTONITE FLOCCULATION, TRICHINELLA SPIRALIS (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: OAB-q Questionnaire Question described as the Overactive Bladder Questionnaire (OAB-q) Caused you to plan activities more carefully?\nConcepts: Resynchronization Defibrillator/Pacemakers (Defibrillator/Cardioverter/Pacemakers, Implantable)\torganic hydroxy compound metabolic process (Molecular Function)\tCHGB (Chromogranin Gene)\tSystemic lupus erythematosus disease activity index (disease activity index)\tOABQ01-Plan Activities More Carefully (OAB-q Questionnaire Question)", + "output": "OABQ01-Plan Activities More Carefully (OAB-q Questionnaire Question)" + }, + { + "input": "Definition: Leiomyosarcoma of uterus described as a rare malignant mesenchymal tumor of smooth muscle origin characterized histologically by spindle and/or pleomorphic cells, often forming disorganized fascicles, with tumor cell necrosis. Macroscopic characteristics are a large soft usually intramural mass with irregular borders and necrotic and hemorrhagic areas located in the uterus. Presenting signs and symptoms typically include dysfunctional vaginal bleeding, vaginal discharge, palpable pelvic mass and/or pelvic pain/pressure. Changes in bowel habits, frequent or painful urination and hematuria may also be associated.\nConcepts: 9p13 (Cell Component)\tLeiomyosarcoma of the Uterine Body (Female internal genitalia structure)\treasoning (Problem Solving)\tEKV3 (Hearing loss associated with syndrome)\tIVD Test Reagent/Kits, Serology, Bacteria, Listeria monocytogenes, IgG Antibody (IVD Test Reagent/Kits, Serology, Bacteria, Listeria monocytogenes, Antibody)", + "output": "Leiomyosarcoma of the Uterine Body (Female internal genitalia structure)" + }, + { + "input": "Definition: Lasers described as lasers designed to produce Nd:YAG (yttrium-aluminum-garnet crystal doped with neodymium), frequency-doubled Nd:YAG, and ruby laser beams from a single unit that is intended for dermatologic treatments. The beams produced by the Nd:YAG, frequency-doubled Nd:YAG, and ruby lasers operate at wavelengths of 1,064 nm, 532 nm, and 694 nm, respectively. These lasers are used in a number of dermatologic applications including treatment of vascular lesions, pigmented lesions, and various cosmetic application (e.g., anti-wrinkle treatment, tattoo removal).\nConcepts: Lasers, Nd:YAG/Nd:YAG Frequency Doubled/Ruby, Dermatologic (Medical Device)\tAt rest (Finding)\tIododeoxyridine (Nucleosides and nucleotides excl. reverse transcriptase inhibitors)\tGenetic Annotation Index (Intellectual Product)\tCell Division Protein Kinase 8 (Cyclin-Dependent Kinases)", + "output": "Lasers, Nd:YAG/Nd:YAG Frequency Doubled/Ruby, Dermatologic (Medical Device)" + }, + { + "input": "Definition: something described as a capsule covered with a substance that is designed to delay the release of active and/or inert ingredient(s) until the capsule passes into the intestines.\nConcepts: Intracavitary Brachytherapy Automated Applicators (Medical Device)\tDelayed Release Oral Capsule (Delayed Release Capsule Dosage Form)\tAbnormal mitral valve physiology (Anatomical Abnormality)\tCP-609,754 (Amino Acid, Peptide, or Protein)\th.pg/mL/m2 (Quantitative Concept)", + "output": "Delayed Release Oral Capsule (Delayed Release Capsule Dosage Form)" + }, + { + "input": "Definition: Hemoglobin measurement described as a measurement of the total amount of hemoglobin in the reticulocyte population.\nConcepts: CHr (Laboratory Procedure)\tCarib Language (Ge-Pano-Carib language)\tMetocarbamol (skeletal muscle relaxants)\tVESSEL, LYMPHATIC (Lymphoid organ structure)\tNurse simple existing in-facility 10 minutes (Health Care Activity)", + "output": "CHr (Laboratory Procedure)" + }, + { + "input": "Definition: Virus described as the type species of the genus VESIVIRUS infecting pigs. The resulting infection is an acute febrile disease which is clinically indistinguishable from FOOT AND MOUTH DISEASE. Transmission is by contaminated food.\nConcepts: DIVERTICULUM (Diverticulosis)\tIn general, would you say your quality of life is (Intellectual Product)\tSwine Vesicular Exanthema Virus (Calicivirus)\tGrowth Differentiation Factor 5 (Biologically Active Substance)\tFracture of femur (Fracture)", + "output": "Swine Vesicular Exanthema Virus (Calicivirus)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide.\nConcepts: (S)-2-haloacid halidohydrolase activity (hydrolase activity, acting on acid halide bonds, in C-halide compounds)\tREMOVAL OF THYROID (thyroid surgery type of procedure)\tnegative regulation of histone acetylation (regulation of histone acetylation)\tLack of Appetite Score 3 (Lack of Appetite Visual Analogue Scale)\tNAFLD (Liver diseases)", + "output": "(S)-2-haloacid halidohydrolase activity (hydrolase activity, acting on acid halide bonds, in C-halide compounds)" + }, + { + "input": "Definition: something described as a liposome-encapsulated formulation of paclitaxel, a taxoid compound extracted from the Pacific yew tree Taxus brevifolia, with antineoplastic property. Paclitaxel binds to tubulin and interferes with the assembly/disassembly dynamics of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis via inactivation of the apoptosis inhibitor, B-cell Leukemia 2 (Bcl-2) protein. Paclitaxel liposome formulation potentially enhances delivery of higher doses of paclitaxel to the target tissues and exhibits lower systemic toxicity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2631\" active clinical trials using this agent.\nConcepts: Cytochrome P-450 CYP2C9 Inhibitors (Pharmacologic Substance)\tAdverseEvent.locationDescription (Intellectual Product)\tcofactor biosynthetic process (cellular biosynthetic process)\tliposome-encapsulated paclitaxel (Pharmacologic Substance)\tD-glucuronate isomerase activity (Molecular Function)", + "output": "liposome-encapsulated paclitaxel (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a regimen consisting of bendamustine and cytarabine that can be used in the treatment of mantle-cell lymphoma (MCL).\nConcepts: ADL0311 (Intellectual Product)\tpericarditis (Inflammatory disorder of the cardiovascular system)\tMammoths (Family Elephantidae)\tphytochelatin-metal complex formation (Molecular Function)\tBAC (Regimen Used to Treat Non-Hodgkin Lymphoma)", + "output": "BAC (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Microcephaly described as a rare genetic malformation syndrome with short stature characterised by postnatal microcephaly, failure to thrive, global developmental delay and intellectual disability, hypotonia, dysmorphic features (short nose, depressed nasal bridge, low set ears, short neck, clinodactyly and cutaneous syndactyly of T2-3 at birth and broad forehead, midface retrusion, epicanthal folds, laterally sparse eyebrows, short nose, long philtrum, widely spaced teeth, micrognathia and coarsening of facial features later in life). Other associated features include postnatal transient generalised oedema, myopia, strabismus, hypothyroidism.\nConcepts: CC-ATLAS TESTCD (Intellectual Product)\tGlycoprotein, NOS (Proteins)\tMicrocephaly, short stature, intellectual disability, facial dysmorphism syndrome (Disease or Syndrome)\t2-13C Acetate (Indicator, Reagent, or Diagnostic Aid)\tDSG3AB (Immunologic Tests)", + "output": "Microcephaly, short stature, intellectual disability, facial dysmorphism syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as a wide pore channel activity that enables the transport of a solute across a membrane via a gap junction hemi-channel. Two gap junction hemi-channels coupled together form a complete gap junction.\nConcepts: BODY TEMPERATURE DEREGULATION (Physical Regulation Component)\tconnexon channel activity (wide pore channel activity)\tRNPSMAB (Immunologic Tests)\t1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole (Imidazoles)\tEvidence-based dentistry (Dentistry)", + "output": "connexon channel activity (wide pore channel activity)" + }, + { + "input": "Definition: Pregnanes described as the acetate salt form of fluorometholone, a synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Fluorometholone acetate exerts its effect by interacting with cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions.\nConcepts: generators ozone (Electromechanical Devices)\tNotch receptor signalling pathway involved in negative regulation of venous endothelial cell fate commitment (Notch Signaling Pathway)\tNerve Endings, Presynaptic (Cell Component)\tfluorometholone acetate (ophthalmic) (Synthetic glucocorticoid, fluorinated)\tBothered By Skin Problems (Findings-Based Question)", + "output": "fluorometholone acetate (ophthalmic) (Synthetic glucocorticoid, fluorinated)" + }, + { + "input": "Definition: Connection Problem described as problem associated with the device being unassociated in such a way that fluid, gas, power or signal information may not be transferred from one device to another.\nConcepts: 5p13.1 (Chromosome band)\tWNT2 Gene (Gene or Genome)\tsocial history (Definitions of Commonly Used Terms (Evaluation and Management (E/M) Services))\tDecoupling (Finding)\tProtein S, antigenic assay (Coagulation factor measurement)", + "output": "Decoupling (Finding)" + }, + { + "input": "Definition: Unapproved attribute described as a term referring to the pathologic observation of a tumor extension or migration from its original site of growth to another non-adjacent site.\nConcepts: Chondrodysplasia with joint dislocations gPAPP type (Multiple dislocations with dysplasia)\tcinacalcet HCl (naphthalene)\tMT (Functional Concept)\tnormocytic; anemia (Anemia)\tKnowledge: Cancer Management (Knowledge Health Condition)", + "output": "MT (Functional Concept)" + }, + { + "input": "Definition: Esthesia described as clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.\nConcepts: band (Cell Component)\tendodontics (Dentistry)\tResolving power of eye (Physical aging status)\tMNSI106 (MNSI Questionnaire Question)\tfruit septum development (Physiologic Function)", + "output": "Resolving power of eye (Physical aging status)" + }, + { + "input": "Definition: Anatomical Abnormality described as sclerosis of the epiphysis of the middle phalanx of the ring finger, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.\nConcepts: Musculoskeletal chest pain due to rib injury (Musculoskeletal chest pain)\tarchaeal proton-transporting A-type ATPase complex location (proton-transporting two-sector ATPase complex)\tCitric Acid Cycle (Metabolic Pathway)\tmediolateral intercalation (cell migration involved in gastrulation)\tIncreased bone density of end part of the middle ring finger bone (Anatomical Abnormality)", + "output": "Increased bone density of end part of the middle ring finger bone (Anatomical Abnormality)" + }, + { + "input": "Definition: QIDS-C Clinical Classification Question described as quick Inventory of Depressive Symptomatology Clinician-Rated Version (QIDS-C) Please circle one response to each item that best describes the patient for the last seven days: Weight (decrease) within the last two weeks.\nConcepts: Smoothened antagonist LDE225 topical (Pharmacologic Substance)\tSDTM-CARTDOM (Intellectual Product)\tU.S. Mail (Professional Organization or Group)\tSGRQC1-How Often Do You Have Good Days (Intellectual Product)\tQIDS-C - Weight (QIDS-C Clinical Classification Question)", + "output": "QIDS-C - Weight (QIDS-C Clinical Classification Question)" + }, + { + "input": "Definition: Biological Factors described as autologous CD34+ hematopoietic stem cells transduced with Lenti-D lentiviral vector encoding the human ATP-binding cassette, sub-family D, member 1 (ABCD1) cDNA, for the potential treatment of childhood cerebral adrenoleukodystrophy (CCALD). Upon administration of the lenti-D/ABCD1-transduced autologous hematopoietic stem cells, the cells proliferate, and some travel to the brain and differentiate into microglial cells. The expressed ABCD1 restores the function of ALD protein (ALDP) and aids in the treatment of CCALD. In CCALD, the ABCD1 gene is mutated, leading to the inability of patients to metabolize very long chain fatty acids in cells of the brain. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C111902\" active clinical trials using this agent.\nConcepts: Denture Base (Dentures and Denture Products)\tGrade 1 Aspartate Aminotransferase Increased, CTCAE (Finding)\tLenti-D/ABCD1-transduced autologous hematopoietic stem cells (Biological Factors)\tNeurologic (Anatomy Qualifier)\tinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration (presynaptic modulation of chemical synaptic transmission)", + "output": "Lenti-D/ABCD1-transduced autologous hematopoietic stem cells (Biological Factors)" + }, + { + "input": "Definition: Finding described as ankle reflex reduced\nConcepts: Rectal Tumors (Pelvic Neoplasms)\tAccessory Nerve Disease (Finding of head and neck region)\tGrade 1 Tendon reflex decreased (Finding)\tincreased; density (Property or Attribute)\tBRUCE protein, human (Biologically Active Substance)", + "output": "Grade 1 Tendon reflex decreased (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as a class of quinoline compounds defined by the presence of two aromatic ring structures which are attached via a side chain to carbon 3 of the qunolinyl structure. The two aromatic moieties are typically NAPTHALENE and BENZENE. Several compounds in this class are used as ANTITUBERCULAR AGENTS.\nConcepts: Thyroglobulin product (Tissue specific)\tDiarylquinoline Derivative (Quinolines)\tMaxilla residual ridge morphology with hamular notch present (Maxilla residual ridge morphology)\t4-methylumbelliferyl glucoside 6'-O-malonyltransferase activity (Molecular Function)\tCervicocranial syndrome (Other dorsopathies, not elsewhere classified)", + "output": "Diarylquinoline Derivative (Quinolines)" + }, + { + "input": "Definition: CDH3 gene described as human CDH3 wild-type allele is located in the vicinity of 16q22.1 and is approximately 54 kb in length. This allele, which encodes cadherin-3 protein, is involved in calcium-dependent cell-cell adhesion. Mutations in this gene have been associated with congential hypotrichosis and juvenile macular dystrophy.\nConcepts: Antibiotic Drugs (Pharmaceutical Preparations)\tdemonstrated behavior perseveration (Behavior assessment)\tChrysotropic Acid (Umbelliferones)\tGasserian Meningioma (Supratentorial Meningioma)\tCDH3 wt Allele (CDH3 gene)", + "output": "CDH3 wt Allele (CDH3 gene)" + }, + { + "input": "Definition: something described as any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis.\nConcepts: Grade 1 Small intestinal stenosis (Small Intestinal Stenosis, CTCAE)\tGTP-Binding Protein Homologous To Saccharomyces Cerevisiae SEC4 (Regulatory Protein)\tNeutrophil immunodeficiency syndrome (Disease or Syndrome)\tguanine salvage (Molecular Function)\tphotoradiation (Light)", + "output": "guanine salvage (Molecular Function)" + }, + { + "input": "Definition: Ampulla of Vater Cancer Pathologic Primary Tumor TNM Finding v8 described as ampulla of Vater cancer in which the primary tumor cannot be assessed.\nConcepts: morbillinum/measles nosode (Organic Chemical)\tAmpulla of Vater Carcinoma pTX TNM Finding v8 (Finding)\tSubstance-Induced Persisting Amnestic Disorder (Substance-Related Disorders)\tC. orthopsilosis (Candida parapsilosis Complex)\tdichloroacetate (Organic Chemical)", + "output": "Ampulla of Vater Carcinoma pTX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of strongyloides IgG antibody present in a sample.\nConcepts: STRIGGAB (Immunoglobulin measurement)\t11q24 (Chromosome band)\tMigration Inhibitory Factor (Mediator of immune response)\tL-menthol Preparation NPO-11 (Pharmacologic Substance)\tthymopoietin (Hormones)", + "output": "STRIGGAB (Immunoglobulin measurement)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of the amyloid alpha precursor protein in a biological specimen.\nConcepts: Amyloid Alpha Precursor Protein Measurement (Protein or Enzyme Type Measurement)\tefferent cochlear group (somatic motoneuron pools)\tCD4 positive lymphocyte depletion (Abnormal Immunology Test Result)\tMalaria Findings About Test Code (Intellectual Product)\tDon't Want help (Clinical or Research Assessment Answer)", + "output": "Amyloid Alpha Precursor Protein Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Organic Chemical described as a second-generation epothilone with potential antineoplastic activity. Epothilone KOS-1584 binds to tubulin and induces microtubule polymerization and stabilizes microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. Compared to first-generation epothilones, this agent exhibits greater safety and efficacy with an enhanced pharmaceutical profile, including enhanced water solubility and tumor penetration, and reduced CNS exposure. In addition, epothilone KOS-1584 is a poor substrate for the P-glycoprotein (P-gp) drug efflux pump. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77892\" active clinical trials using this agent.\nConcepts: CMT4B3 (Disease or Syndrome)\tISG15 transferase activity (ubiquitin-like protein transferase activity)\tPODCI2-Miss School Because of Health (Intellectual Product)\tSoftware, Information System, Healthcare Facility, Administrative, Internet of Things Security (Intellectual Product)\tEpothilone KOS-1584 (Pharmacologic Substance)", + "output": "Epothilone KOS-1584 (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as an antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS.\nConcepts: INFECT HELICOBACTER (Gram-Negative Bacterial Infections)\tPQL1706 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)\tRevM10 gene (Gene or Genome)\t8: 82552004-82553481 (Chromosome 8 Physical Location)\tProximal scleroderma (Scleroderma)", + "output": "RevM10 gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a measure of the precision of an estimated value. The interval represents the range of values, consistent with the data, that is believed to encompass the \"true\" value with high probability (usually 95%). The confidence interval is expressed in the same units as the estimate. Wider intervals indicate lower precision; narrow intervals, greater precision.\nConcepts: Begelomab (Immunologic Factor)\tSecondary malignant neoplasm of retina (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE NERVOUS SYSTEM AND SPECIAL SENSE ORGANS)\tConfidence Intervals (Dispersion)\t1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (Molecular Function)\t1 (Illness Intrusiveness Ratings Scale)", + "output": "Confidence Intervals (Dispersion)" + }, + { + "input": "Definition: something described as characterization of salmonella bacteria subspecies as serotype group C2 based on the specific immunologic reactivity of cell surface lipopolysaccharide-protein chains called O antigens.\nConcepts: Salmonella Serotype Group C2 (Salmonella)\t17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tcyanidol (Anthocyanidins)\tCell, Retinal Cone (Neuron of retina)\tStand-up wheelchair (Medical Device)", + "output": "Salmonella Serotype Group C2 (Salmonella)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glyoxylate + H(2)O + O(2) = H(2)O(2) + H(+) + oxalate.\nConcepts: dosages (Property or Attribute)\tpositive regulation of chemokine formation (regulation of chemokine biosynthetic process)\tCaecal haemorrhage (Intestinal hemorrhage NOS)\tglyoxylate:oxygen oxidoreductase activity (Molecular Function)\tlumens (Body Regions)", + "output": "glyoxylate:oxygen oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as completion of medical or psychological/behavioral treatment programs. Compare TREATMENT DROPOUTS.\nConcepts: ATP-dependent glycerol-2-phosphate transmembrane transporter activity (carbohydrate derivative transmembrane transporter activity)\tCAV2 wt Allele (Gene or Genome)\texaprolol (Organic Chemical)\tmidbrain DA neurogenesis (dopaminergic neuron differentiation)\tTreatment Termination (Treatment (General))", + "output": "Treatment Termination (Treatment (General))" + }, + { + "input": "Definition: Microorganism described as any bacteria with a shape between that of a sphere and a rod that contains low levels of peptidoglycan in its cell wall and stains pink with the Gram staining technique.\nConcepts: Congenital Phrenic Nerve Injury (Injury of phrenic nerve)\tGram-negative coccobacillus (Microorganism)\tThrombospondin Receptor Negative (Expression Negative)\tEBP1 (Gene or Genome)\t1 (Arabic numeral)", + "output": "Gram-negative coccobacillus (Microorganism)" + }, + { + "input": "Definition: Aves described as PASSERIFORMES of the suborder, Oscines, in which the flexor tendons of the toes are separate, and the lower syrinx has 4 to 9 pairs of tensor muscles inserted at both ends of the tracheal half rings. They include many commonly recognized birds such as CROWS; FINCHES; robins; SPARROWS; and SWALLOWS.\nConcepts: Cervical Cancer pT1a TNM Finding v7 (Cervical Cancer pT1 TNM Finding v7)\tBreast Cancer, Education (Educational Activity)\tSolution for injection/skin-prick test (Injectable Solution)\tOscine (Order Passeriformes)\tTrastuzumab-Pertuzumab-Vinorelbine (Therapeutic or Preventive Procedure)", + "output": "Oscine (Order Passeriformes)" + }, + { + "input": "Definition: Disease due to Alphaherpesvirinae described as an acute infectious, usually self-limited, disease believed to represent activation of latent varicella-zoster virus (HERPESVIRUS 3, HUMAN) in those who have been rendered partially immune after a previous attack of CHICKENPOX. It involves the SENSORY GANGLIA and their areas of innervation and is characterized by severe neuralgic pain along the distribution of the affected nerve and crops of clustered vesicles over the area.\nConcepts: STK11 Mutation (Cell or Molecular Dysfunction)\tUtricle and Saccule (Vestibular Labyrinth)\tNon-Profit Corporation (Company)\tFusiform aortic arch aneurysm (Aneurysm of aortic arch)\tShingles (Elderly)", + "output": "Shingles (Elderly)" + }, + { + "input": "Definition: Unit dose described as a dosing unit equal to the amount of active ingredient(s) contained in a pad.\nConcepts: ASD (MYO ENDO PERICARDIAL & VALVE DISORDERS)\tPad (Quantitative Concept)\tbenign epithelial neoplasm of ovary (Epithelial tumor of ovary)\tNervus Accessorius (Body Part, Organ, or Organ Component)\tnegative regulation of DDX58 signaling pathway (negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway)", + "output": "Pad (Quantitative Concept)" + }, + { + "input": "Definition: something described as catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group.\nConcepts: methanesulphonic acid metabolism (Molecular Function)\tribonuclease E activity (Genetic Function)\tPIRADS (Classification)\tdecerebrate rigidity was noted (Muscle Rigidity)\tWHODAS 2.0 36-item Version Self-administered - Making New Friends (Intellectual Product)", + "output": "ribonuclease E activity (Genetic Function)" + }, + { + "input": "Definition: something described as a species of obligately anaerobic, Gram-positive, rod-shaped, non-motile, spore-forming bacteria in the family Clostridiaceae. I. bartlettii is negative for lecithinase, lipase, catalase and urease, and is unable to hydrolyze esculin or gelatin, or reduce nitrate to nitrite, but positive for acid phosphatase, galactosidase and beta-glucuronidase. The species was originally isolated from fecal samples.\nConcepts: Magnesium Hydroxide/Aluminum Hydroxide/Simethicone Suspension (Antacids)\tBrachial (root)\tClostridium bartlettii Song et al. 2004 (Intestinibacter)\tObserved Mean Residence Time Infinity (Mean Residence Time)\tregulation of establishment of endothelial barrier (regulation of endothelial cell development)", + "output": "Clostridium bartlettii Song et al. 2004 (Intestinibacter)" + }, + { + "input": "Definition: Microscopy described as microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light.\nConcepts: Grade 3 Neonatal Diarrhea, AE (Neonatal Diarrhea, Adverse Event)\tInsufficient Evidence for Preeclampsia with Severe Features (Intellectual Product)\tprotozoal vaccine (Immunologic Factor)\tFluorescence Light Microscopy (Light Microscopy)\tDecontamination Systems (Medical Device)", + "output": "Fluorescence Light Microscopy (Light Microscopy)" + }, + { + "input": "Definition: transferase activity, transferring alkyl or aryl (other than methyl) groups described as catalysis of the reaction: S-adenosyl-L-methionine + fluoride = 5'-deoxy-5'-fluoroadenosine + L-methionine.\nConcepts: adenosyl-fluoride synthase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)\tactivation of reciprocal meiotic recombination (Cell Function)\tSimple new home-visit 10 minutes (Therapeutic or Preventive Procedure)\tCRSR01-Total Score (CRS-R Clinical Classification Question)\tEx Vivo-activated Autologous Lymph Node Lymphocytes (therapeutic autologous lymphocytes)", + "output": "adenosyl-fluoride synthase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)" + }, + { + "input": "Definition: Finding described as a reduction in the level of thymic horomone.\nConcepts: maintenance of rhodopsin mediated signalling (regulation of membrane potential in photoreceptor cell)\tGlucagon Like Peptide 2 (Peptide hormones and their metabolites and precursors)\tAVL01134 (Intellectual Product)\tAmino Acid Transport Systems, Acidic (Amino Acid Transporter)\tThymic hormone decreased (LABORATORY ABNORMALITIES)", + "output": "Thymic hormone decreased (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Euchromatin described as the dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin.\nConcepts: nuclear euchromatin (euchromatin location)\tProcedure Kit/Trays, Anesthesia (Procedure Kit/Trays)\tEWSR1/SP3 Fusion Protein (Amino Acid, Peptide, or Protein)\tleishmania infections (Arthropod-borne infectious disease)\tNasal bridge length line (Body Location or Region)", + "output": "nuclear euchromatin (euchromatin location)" + }, + { + "input": "Definition: Finding described as absent or nearly absent fibula. (Does not include aplastic) []\nConcepts: ankle; pain, joint (Arthralgia of the ankle and/or foot)\tSmall to absent fibula (Finding)\tTractus bulboreticulospinalis (Spinal cord, roots and ganglia structure)\tHAQ-DI With VAS - Aids or Devices - Wheelchair (HAQ-DI Questionnaire Question)\tlytic vacuole membrane (vacuolar membrane)", + "output": "Small to absent fibula (Finding)" + }, + { + "input": "Definition: something described as any process that activates, maintains or increases the frequency, rate or extent of symbiont penetration hypha formation for entry into host. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Stage II Renal Pelvis Cancer AJCC v7 (Neoplastic Process)\tNSAA1-Jump (Intellectual Product)\tpositive regulation of symbiont penetration hypha formation for entry into host (Biologic Function)\tPeritoneal Desmoplastic Small Round Cell Tumor (Neoplastic Process)\tGL331 (Epipodophyllotoxin)", + "output": "positive regulation of symbiont penetration hypha formation for entry into host (Biologic Function)" + }, + { + "input": "Definition: something described as skin which is white and it usually burns easily when exposed to the sun. It is usually seen in people with blond or red hair and blue or hazel eyes.\nConcepts: Fitzpatrick Skin Type II (Fitzpatrick Classification Scale)\tDisperse (Dose form transformation)\tAnti-PSMA Monoclonal Antibody MLN591-DM1 Immunoconjugate MLN2704 (Pharmacologic Substance)\tdistal muscular dystrophy (Autosomal recessive muscular dystrophy not predominantly limb girdle)\tMalaligned philtral columns (Abnormality of the philtrum)", + "output": "Fitzpatrick Skin Type II (Fitzpatrick Classification Scale)" + }, + { + "input": "Definition: Immunologic Factor described as a monoclonal antibody targeting the human cell surface antigen CD47, with potential phagocytosis-inducing and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody CC-90002 selectively binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with signal regulatory protein alpha (SIRPa), a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling and abrogates the CD47/SIRPa-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages. This results in macrophage activation and the specific phagocytosis of tumor cells. In addition, blocking CD47 signaling activates both an anti-tumor T-lymphocyte immune response and T cell-mediated killing of CD47-expressing tumor cells. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSC) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPa, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate.\nConcepts: anti-CD47 monoclonal antibody CC-90002 (Antineoplastic Antibody)\tSTENT, SUPERFICIAL FEMORAL ARTERY (Medical Device)\tpolyphenic determination, influence by genetic factors (Phenomenon or Process)\tgluten intolerance (Intolerance to protein)\tGrade 4 Pancreatitis (Finding)", + "output": "anti-CD47 monoclonal antibody CC-90002 (Antineoplastic Antibody)" + }, + { + "input": "Definition: Leads, External Cardiac Pacemaker described as external cardiac pacemaker invasive leads designed to conduct electrical pacing signals from the pulse generator of an external pacemaker through the esophagus and into the heart. Some leads may also conduct the bioelectric cardiac signals back to the unit. These leads typically consist of flexible wires that are completely isolated except at the electrode tip. Transesophageal pacemaker leads are configured according to the pacemaker characteristics and/or the technique used for signal delivery to the heart. A variety of lead systems, including single- and multiple-lead is available. Lead size, connector type, and other characteristics of the leads must be compatible with the pulse generator and the therapy prescribed. Endocardial external cardiac pacemaker leads are used in temporary procedures (e.g., surgery, emergency, electrophysiology studies).\nConcepts: Intention to Treat Analysis (Research Activity)\tFast Foods (General food type)\tThyroid Cancer Pathologic Primary Tumor TNM Finding v7 (Finding)\tLeads, External Cardiac Pacemaker, Transesophageal (Medical Device)\t(10-((1RS,2SR)-2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triacetato(3-))gadolinium (Magnetic resonance imaging contrast media)", + "output": "Leads, External Cardiac Pacemaker, Transesophageal (Medical Device)" + }, + { + "input": "Definition: Hematology described as basic research in the field of hematology.\nConcepts: Bile acid coenzyme A ligase deficiency and defective amidation (Disease or Syndrome)\tarchives (Information Systems)\tSILODOSIN (S [Preparations])\tConcentration After the Nth Dose by Dose (Quantitative Concept)\tHematology, Experimental (Biomedical Occupation or Discipline)", + "output": "Hematology, Experimental (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Genetic Techniques described as a gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.\nConcepts: Visit Name (Name)\tPain Interferes with General Activity (Findings-Based Question)\tplastid single subunit type RNA polymerase activity (single subunit type RNA polymerase activity)\tGene Silencing, Posttranscriptional (posttranscriptional regulation of gene expression)\tlow affinity sulfate:proton symporter activity (sulfate:proton symporter activity)", + "output": "Gene Silencing, Posttranscriptional (posttranscriptional regulation of gene expression)" + }, + { + "input": "Definition: Rabbit Neoplasm described as cutaneous lymphoma that occurs in a rabbit.\nConcepts: Leishmania leishmania mexicana (Leishmania mexicana species complex)\tRabbit Cutaneous Lymphoma (Neoplastic Process)\tSerum Gamma Glutamyl Transpeptidase Measurement (Laboratory Procedure)\tunconventional myosin complex (myosin complex)\tINGUINAL HERNIA INCARCERATED (Hernia, Inguinal)", + "output": "Rabbit Cutaneous Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Regulatory Protein described as a class of proteins that are involved in the inhibition of enzymes.\nConcepts: Enzyme Inhibitor Protein (Regulatory Protein)\tSeeking work (Personal Attribute)\tQ-LES-Q - Relationships Without Problems (Intellectual Product)\tplasma lipoprotein particle (Cell Component)\t(+)-Biotin (thiophene)", + "output": "Enzyme Inhibitor Protein (Regulatory Protein)" + }, + { + "input": "Definition: Finding described as a lesion found in the division of a vessel into at least two branches, each of which is 1.5 mm or greater in diameter.\nConcepts: Coronary Vessel Bifurcation Lesion (Finding)\tQIDSC1 (Intellectual Product)\tG protein subunit gamma 11 (Gene or Genome)\tbrain tumor malignant astrocytoma (Primary malignant astrocytoma of central nervous system)\tUnit/Square Meter (Unit of Dose Calculation)", + "output": "Coronary Vessel Bifurcation Lesion (Finding)" + }, + { + "input": "Definition: Hematologic Tests described as a technique for removing T lymphocytes based on differential agglutination with soybean lectin.\nConcepts: dTDP-fucosamine aminotransferase activity (Molecular Function)\tSoybean Lectin Agglutination (Hematologic Tests)\tUterine Infection, CTCAE (Finding)\tBPI108 (BPI Questionnaire Question)\tcell-to-cell signaling (biological signaling)", + "output": "Soybean Lectin Agglutination (Hematologic Tests)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of the D-enantiomer of the hexose monosaccharide glucose from one side of a membrane to the other.\nConcepts: lymphokine-activated killer cells (Natural Killer Cells)\tHypoalphalipoproteinemias (Rare Non-Neoplastic Disorder)\tD-glucose transmembrane transporter activity (glucose permease activity)\tU11 snRNA binding (Genetic Function)\tMultiplex Real-time Polymerase Chain Reaction Assay (Real-Time Polymerase Chain Reaction)", + "output": "D-glucose transmembrane transporter activity (glucose permease activity)" + }, + { + "input": "Definition: something described as procedure in which arterial blood pressure is intentionally reduced in order to control blood loss during surgery. This procedure is performed either pharmacologically or by pre-surgical removal of blood.\nConcepts: Capillary Hemangioma of the Breast (Neoplastic Process)\tImpedance testing each 15 minutes (Body Composition)\tTLR15 signaling pathway (Toll-Like Receptor Signaling Pathway)\tHypotension, Induced (Therapeutic or Preventive Procedure)\tUPD2206 (Intellectual Product)", + "output": "Hypotension, Induced (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Immunologic Factor described as a vaccine containing an inactivated epitope of tetanus toxin fused to a cytomegalovirus (CMV) peptide epitope, with potential anti-viral and immunomodulating activities. Upon administration, tetanus-CMV fusion peptide may stimulate a cytotoxic T-lymphocyte (CTL) response against CMV in the CMV-infected host. Tetanus toxin contains universal T cell helper epitopes.\nConcepts: It is hard for me to ask the doctors and nurses (Clinical or Research Assessment Question)\tFACT-G Version 4 - I Am Forced to Spend Time in Bed (FACT-G Version 4 Questionnaire Question)\tTetanus-CMV Fusion Peptide Vaccine (Immunologic Factor)\tDelta1 complex (plasma membrane protein complex)\tDNER wt Allele (Gene or Genome)", + "output": "Tetanus-CMV Fusion Peptide Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: something described as a histologic variant of squamous cell carcinoma that arises from the skin. It is characterized by loosening of the intercellular bridges between the malignant cells which results in acantholysis.\nConcepts: skin neoplasm carcinoma squamous cell acantholytic (Malignant epithelial neoplasm of skin)\tStage II Small Intestine Carcinoma (Small Intestinal Cancer by AJCC v7 Stage)\tLung Water Monitors (Medical Device)\tFAMS0124 (Intellectual Product)\tSGRQ Past 4 Weeks Version - Walking Up Hills (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)", + "output": "skin neoplasm carcinoma squamous cell acantholytic (Malignant epithelial neoplasm of skin)" + }, + { + "input": "Definition: Organic Chemical described as a pegylated liposomal formulation comprised of a lipophilic prodrug of the antineoplastic antibiotic mitomycin C containing a cleavable disulfide bond (PL-MLP), with potential antineoplastic activity. Upon administration of the pegylated liposomal mitomycin C lipid-based prodrug, the MLP moiety becomes activated upon thiolysis at the tumor site, thereby releasing mitomycin C. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. The thiolytic environment and upregulated expression of thioredoxins at the tumor site allow for the activation and release of mitomycin C. This prodrug formulation allows for greater circulation time, less systemic toxicity and increased accumulation of mitomycin C at the tumor site.\nConcepts: Immunologic Technique (Laboratory Procedure)\tcingulate cortex (Cerebral cortex)\tMagnolia / hou po / xin yi (Plant)\tCystitides, Interstitial (Lesion of bladder)\tpegylated liposomal mitomycin C lipid-based prodrug (Organic Chemical)", + "output": "pegylated liposomal mitomycin C lipid-based prodrug (Organic Chemical)" + }, + { + "input": "Definition: Professional or Occupational Group described as electrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairments of the neurologic, neuromuscular, and/or muscular systems. Qualified physicians are trained in performing electrophysiological testing and interpretation of the test data. They require knowledge in anatomy, physiology, kinesiology, histology, and pathology of the brain, spinal cord, autonomic nerves, cranial nerves, peripheral nerves, neuromuscular junction, and muscles. They must know clinical features and treatment of diseases of the central, peripheral, and autonomic nervous systems, as well as those of neuromuscular junction and muscle. Physicians also require special knowledge about electric signal processing, including waveform analysis, electronics and instrumentation, stimulation and recording equipment, and statistics.\nConcepts: Colorectal Undifferentiated Carcinoma (Undifferentiated carcinoma)\tCD86 biosynthesis (Molecular Function)\trnrx chronic pain control (Procedure with a clinical finding focus)\tAllopathic & Osteopathic Physicians; Electrodiagnostic Medicine (Professional or Occupational Group)\tBIFIDOBACTERIUM ADOLESCENTIS (Bacterium)", + "output": "Allopathic & Osteopathic Physicians; Electrodiagnostic Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: cell wall polysaccharide metabolic process described as the chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units.\nConcepts: mannan metabolic process (Molecular Function)\tImage Artifact (Finding)\tCSS0810 (Intellectual Product)\tFibrolamellar Cancer (Primary malignant adenomatous neoplasm)\tInterdigitating Dendritic Cell Sarcoma (Histiocytic Disorders, Malignant)", + "output": "mannan metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as interstitial pneumonia characterized by the presence of bibasilar pulmonary interstitial infiltrates composed of lymphocytes and plasma cells. It may be associated with autoimmune and lymphoproliferative disorders. Signs and symptoms include fever, cough, and dyspnea. Symptomatic patients may require immunosuppressive treatment.\nConcepts: ANTIGENS, HA (INCLUDING HA CONTROL), PARAINFLUENZA VIRUS 1-4 (Indicator, Reagent, or Diagnostic Aid)\tLymphocytic Interstitial Pneumonia (Chronic inflammation)\tobsolete protein complex assembly, multichaperone pathway (Molecular Function)\tPLASMODIUM MALARIAE (Plasmodium )\tdown regulation of advanced glycation end-product receptor activity (negative regulation of signaling receptor activity)", + "output": "Lymphocytic Interstitial Pneumonia (Chronic inflammation)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized.\nConcepts: Pneumoniae (Non-infectious pneumonia)\tDevice Approvals (Consumer Product Safety)\tAcetyl 2 methylcholine Chloride (Muscarinic Agonists)\tspecification of petal identity (Organ or Tissue Function)\tSmall pastern bone of forelimb (Bone structure of middle phalanx of finger)", + "output": "specification of petal identity (Organ or Tissue Function)" + }, + { + "input": "Definition: D [Preparations] described as the sodium salt form of danaparoid, a synthetic low molecular weight heparin (LMWH) derived from porcine gut mucosa with anticoagulant activity. Danaparoid sodium binds to antithrombin III and inhibits the activity of activated factor X (factor Xa) and, to a lesser extent, activated factor II (thrombin) thereby preventing fibrin formation. Compared to heparin, danaparoid sodium exhibits a much higher ratio of anti-factor Xa activity to anti-factor IIa activity (22:1).\nConcepts: Gamma-Tubulin Ring Complex (Cardinal cell part)\tPROSTHESIS, KNEE, FEMOROTIBIAL, NON-CONSTRAINED, METAL/COMPOSITE CEMENTED (Medical Device)\tDanaparoid sodium (danaparoid)\tNSAA (Intellectual Product)\tOrbital Sarcoma Pathologic Primary Tumor TNM Finding v8 (Finding)", + "output": "Danaparoid sodium (danaparoid)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - If the subject was institutionalized will the subject continue to be assessed for this study?\nConcepts: Rosa alba flower oil extract (Natural Products)\tUHDRS 1999 Version - Continue to Be Assessed for Study (Intellectual Product)\tDeoxyribonucleic acid, NOS (Antigens)\tRas mediated signal transduction (Molecular Function)\tCD1C wt Allele (CD1C gene)", + "output": "UHDRS 1999 Version - Continue to Be Assessed for Study (Intellectual Product)" + }, + { + "input": "Definition: something described as focal facial dermal dysplasias (FFDD) are rare ectodermal dysplasias, with characteristics of congenital bitemporal (resembling forceps marks) or preauricular scar-like lesions associated with additional facial and or systematic manifestations. Four types of FFDD are described. Types II and III present with a variable facial dysmorphism including distichiasis (upper lashes) or lacking eyelashes, and upward slanting and thinned lateral eyebrows with a flattened nasal bridge and full upper lip. Types I and IV are infrequently associated with extra-cutaneous anomalies.\nConcepts: Dopamine Secreting (Hormonal Change)\tNnspcfd HCPCS ostomy eqpmnt (Health Care Activity)\tCytokine Receptor Gene (Receptor Gene)\tReceptor TR2, Nuclear (Orphan Nuclear Receptors)\tFam foc fac derm dysplasia (Aplasia Cutis Congenita)", + "output": "Fam foc fac derm dysplasia (Aplasia Cutis Congenita)" + }, + { + "input": "Definition: Body Fluids described as portion of secreted substance produced prostatic glands, bulbourethral glands or the seminal vesicles.\nConcepts: FIGO Stage IVA Ovarian Cancer (Neoplastic Process)\tActivation Antigens, VLA (Amino Acid, Peptide, or Protein)\tPortion of seminal fluid (Portion of body fluid solution)\tFKSI-DRS Version 4 - I Have Been Coughing (Intellectual Product)\tMethotrexate-Encapsulating Autologous Tumor-Derived Microparticles (Pharmacologic Substance)", + "output": "Portion of seminal fluid (Portion of body fluid solution)" + }, + { + "input": "Definition: Patient Note described as the completed activity within the context of a given study that represents the\nConcepts: PerformedPatientNote (Intellectual Product)\tphragmoplast (cellular anatomical entity)\tJuvenile Absence Epilepsy (Epilepsy, Generalized)\tMouse mammary tumour virus -RETIRED- (Betaretrovirus)\tMemory, Short-Term (Cognition)", + "output": "PerformedPatientNote (Intellectual Product)" + }, + { + "input": "Definition: something described as the approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure) involved in embryonic development, cell lineage, and cell cycle control. The domain shows more diversity in structure and function than the highly conserved sequence suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF complex exhibits non-specific DNA binding activity. ARID family proteins may be involved in a wide range of DNA interactions. Inappropriate expression of ARID proteins is increasingly implicated in tumorigenesis.\nConcepts: BRIGHT Domain (DNA Binding Domain)\tMicroRNA 371-373 Overexpression (Finding)\tThymic Tumor pM1b TNM Finding v8 (Finding)\tCRGF (Growth Factor Gene)\tSRY (Sex Determining Region Y)-Box 18 wt Allele (SOX18 gene)", + "output": "BRIGHT Domain (DNA Binding Domain)" + }, + { + "input": "Definition: Umbilical cord finding described as change in umbilical cord color resulting from postmortem changes. It indicates fetal death occurred at least 6 hours prior to delivery.\nConcepts: Dusky Umbilical Cord (Finding)\tThin nostrils (Nose)\tneuroblastoma-multiple congenital anomalies-mental retardation syndrome (Disease or Syndrome)\tInfant Acute Biphenotypic Leukemia (Infant Leukemia)\tCDC group Vb-2 (Pseudomonas aeruginosa group)", + "output": "Dusky Umbilical Cord (Finding)" + }, + { + "input": "Definition: diagnostic procedure described as an assessment of the intrinsic ability of the myocardium to contract, which subsequently determines the force (pressure) with which blood is ejected from both ventricles, and contributes to measured values like blood pressure and cardiac output.\nConcepts: medulla oblongata morphogenesis (Morphogenesis)\tRib exostoses (Abnormality of the ribs)\tDental Impression Laser/Light Scanning Systems (Dental Equipment and Supplies)\tPostpartum haemorrhage (Female Genital Diseases)\tMyocardial Contractility Measurement (Diagnostic Procedure)", + "output": "Myocardial Contractility Measurement (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as moderate hallucinations\nConcepts: Grade 2 Hallucinations (Finding)\tLMA1 complex location (Cell Component)\tdesflurane (Methyl Ethers)\tAscaridiosis (Ascaridida Infections)\taspartate-prephenate aminotransferase activity (Molecular Function)", + "output": "Grade 2 Hallucinations (Finding)" + }, + { + "input": "Definition: Neuroanatomy described as a column of nerve tissue that runs from the base of the skull down the back. It is surrounded by three protective membranes, and is enclosed within the vertebrae (back bones). The spinal cord and the brain make up the central nervous system, and spinal cord nerves carry most messages between the brain and the rest of the body.\nConcepts: 10^6.[iU]/ml (Quantitative Concept)\tExpiration Relaxation Time (Finding)\tPeptostreptococcus hydrogenalis (Anaerococcus)\tStructure of spinal cord (Body part)\tResins, Plant (Biomedical or Dental Material)", + "output": "Structure of spinal cord (Body part)" + }, + { + "input": "Definition: something described as used for the visualization of an anatomical structure or for the diagnosis of disease. Commonly used imaging techniques include radiography, radionuclide imaging, thermography, tomography, and ultrasonography\nConcepts: diagnostic imaging (Functional Concept)\tAggravated by acetylcholinesterase inhibitor (Symptom aggravating factors)\tPODCI180 (Intellectual Product)\tCSS06-Number of Aborted Attempts (Intellectual Product)\tUracil/Tegafur (Pharmacologic Substance)", + "output": "diagnostic imaging (Functional Concept)" + }, + { + "input": "Definition: Health Care Activity described as a chart-related administrative procedure that involves opening the chart\nConcepts: IVD Panels, Human Genetics, Multisystem Disorder, Stickler Syndrome, Del/Dup (Medical Device)\tligation procedures tubal (Woman)\tmidbody abscission (mitotic cytokinetic process)\tIfosfamide-Cisplatin-Doxorubicin-Methotrexate Regimen (Regimen Used to Treat Childhood Osteosarcoma)\tChart opening (CHART EVALUATION BY MEDICAL RECORDS)", + "output": "Chart opening (CHART EVALUATION BY MEDICAL RECORDS)" + }, + { + "input": "Definition: Medical Device described as an obstetric-gynecologic specialized manual instrument is one of a group of devices used during obstetric-gynecologic procedures to perform manipulative diagnostic and surgical functions (e.g., dilating, grasping, measuring, and scraping), where structural integrity is the chief criterion of device performance. This type of device consists of the following: (1) An amniotome is an instrument used to rupture the fetal membranes. (2) A circumcision clamp is an instrument used to compress the foreskin of the penis during circumcision of a male infant. (3) An umbilical clamp is an instrument used to compress the umbilical cord. (4) A uterine curette is an instrument used to scrape and remove material from the uterus. (5) A fixed-size cervical dilator is any of a series of bougies of various sizes used to dilate the cervical os by stretching the cervix. (6) A uterine elevator is an instrument inserted into the uterus used to lift and manipulate the uterus. (7) A gynecological surgical forceps is an instrument with two blades and handles used to pull, grasp, or compress during gynecological examination. (8) A cervical cone knife is a cutting instrument used to excise and remove tissue from the cervix. (9) A gynecological cerclage needle is a looplike instrument used to suture the cervix. (10) A hook-type contraceptive intrauterine device (IUD) remover is an instrument used to remove an IUD from the uterus. (11) A gynecological fibroid screw is an instrument used to hold onto a fibroid. (12) A uterine sound is an instrument used to determine the depth of the uterus by inserting it into the uterine cavity. (13) A cytological cervical spatula is a blunt instrument used to scrape and remove cytological material from the surface of the cervix or vagina. (14) A gynecological biopsy forceps is an instrument with two blades and handles used for gynecological biopsy procedures. (15) A uterine tenaculum is a hooklike instrument used to seize and hold the cervix or fundus. (16) An internal pelvimeter is an instrument used within the vagina to measure the diameter and capacity of the pelvis. (17) A nonmetal vaginal speculum is a nonmetal instrument used to expose the interior of the vagina. (18) A fiberoptic nonmetal vaginal speculum is a nonmetal instrument, with fiberoptic light, used to expose and illuminate the interior of the vagina.\nConcepts: CHSF201A (Intellectual Product)\tPalate Surgery (Biomedical Occupation or Discipline)\tSPATULA, CERVICAL, CYTOLOGICAL (Medical Device)\tOrgano-nitrogen Carcinogen (Classification)\tI am comfortable with who I am (Intellectual Product)", + "output": "SPATULA, CERVICAL, CYTOLOGICAL (Medical Device)" + }, + { + "input": "Definition: DNA analysis described as a DNA sequencing technique that can both determine DNA methylation status and distinguish non-nucleosomal DNA from nucleosome-associated DNA. This technique subjects samples to both bisulfite treatment to modify unmethylated cytosines and GpC methyltransferase treatment to identify non-nucleosomal DNA regions. The treated samples are then analyzed using next-generation sequencing techniques.\nConcepts: Nucleosome Occupancy and Methylome Sequencing (DNA analysis)\tBite Cells (Red Blood Cell Count measurement)\tEnhancer of Polycomb Homolog 1 (Drosophila) wt Allele (Gene or Genome)\tGrade 4 Fallopian tube anastomotic leak (Finding)\tColon Medullary Carcinoma (Adenocarcinoma of colon)", + "output": "Nucleosome Occupancy and Methylome Sequencing (DNA analysis)" + }, + { + "input": "Definition: something described as solid preparation consisting of one or more powders intended to be dispersed in the specified liquid to obtain an intravesical suspension.\nConcepts: Powder for conventional release intravesical suspension (Intravesical dose form)\tGDC-0077 (Pharmacologic Substance)\tup regulation of endosome membrane budding (positive regulation of endosome organization)\talanine transferase (Enzyme)\tapoptosis of glial cells (Apoptosis)", + "output": "Powder for conventional release intravesical suspension (Intravesical dose form)" + }, + { + "input": "Definition: Manufactured Object described as label printers designed to produce monochromatic bar-coded graphics on paper or plastic (frequently self-adhesive) labels or tags; they may work as a computer-controlled peripheral. These printers typically include a thermal head that may transfer ink from a ribbon to the tag (thermal transfer printer) for a permanent print or perform temporary (up to a year) printing on heat-sensitive tag (direct thermal printer); bar-code printers usually include special feeding mechanisms to manipulate multiple tags provided either in tear sheets or in rolls. Bar-code printers are used in healthcare facilities to mark laboratory samples, for patient and/or equipment identification, and for inventories and other administrative purposes; they are frequently used as components of hospital bar-coded information systems.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Yellow Fever, IgG Antibody (IVD Test Reagent/Kits, Serology, Virus)\tCAM binding (Protein Binding)\tdetection of stimulus involved in sensory perception of pain (detection of stimulus involved in sensory perception)\tThanatophoric dysplasia, type 1 (Disease or Syndrome)\tBar Code Printers (Printers, Label)", + "output": "Bar Code Printers (Printers, Label)" + }, + { + "input": "Definition: Extra-Adrenal Paraganglioma described as a benign or malignant extra-adrenal paraganglioma arising from the central nervous system.\nConcepts: Stage IIA Esophageal Squamous Cell Cancer (Stage IIA Esophagus Carcinoma)\tMammalian Pathway for Cysteine Biosynthesis (Amino Acid Metabolism Pathway)\tDoctor of Optometry (Professional Doctorate)\tCNS Paraganglioma (Central Nervous System Neoplasms, Primary)\tsestamibi scan (Diagnostic Procedure)", + "output": "CNS Paraganglioma (Central Nervous System Neoplasms, Primary)" + }, + { + "input": "Definition: ocellus pigment metabolic process described as the chemical reactions and pathways involving ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye.\nConcepts: Hyperkeratosis follicularis (Exanthema)\tommochrome metabolism (organic cyclic compound metabolic process)\tAssay, Farr (Serologic tests)\tCongenital Reproductive System Abnormality (Urogenital Abnormalities)\tFlatulence (Hepatobiliary Disorder)", + "output": "ommochrome metabolism (organic cyclic compound metabolic process)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare X-linked intellectual disability syndrome with characteristics of failure to thrive, speech delay, intellectual disability, muscle hypotonia, spastic diplegia, optic atrophy with myopia and distinct facial features (including triangular face, bifrontal narrowness, deeply set eyes, low-set/cupped ears, prominent nose, short philtrum, and thin upper lip with tented morphology) that can be evident from birth. Additional manifestations reported in some patients include large joint contractures and pectus excavatum (which become more evident with age) and seizures.\nConcepts: Brooks-Wisniewski-Brown Syndrome (Mental Retardation)\tPneumoperitoneum, Artificial (Diagnostic Procedure)\tL-glutamine import into cell (drug transmembrane transport)\tDrinking Attitudes (Mental Process)\tInfiltrating basal cell carcinoma, non-sclerosing (Primary malignant neoplasm)", + "output": "Brooks-Wisniewski-Brown Syndrome (Mental Retardation)" + }, + { + "input": "Definition: something described as tolerance induction of natural killer cells.\nConcepts: Gracile fascicle of spinal cord (Fasciculus of spinal cord)\tiris; cyst (General visual observation)\tCisplatin/Temozolomide Regimen (Regimen Used to Treat Malignant Brain Neoplasm)\tnatural killer cell tolerance induction (Biologic Function)\tFAC039-I Am Able to Work (FKSI-15 Questionnaire Question)", + "output": "natural killer cell tolerance induction (Biologic Function)" + }, + { + "input": "Definition: something described as a protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is added to a protein. K6-linked ubiquitination is involved in DNA repair.\nConcepts: protein K6-linked polyubiquitination (protein polyubiquitination)\tmanual (Manufactured Object)\tradiology interventional (Biomedical Occupation or Discipline)\tSDTM-DSSOUT (Intellectual Product)\thookworm (Strongylida)", + "output": "protein K6-linked polyubiquitination (protein polyubiquitination)" + }, + { + "input": "Definition: something described as congenital structural deformities, malformations, or other abnormalities of the maxilla and face or facial bones.\nConcepts: Maxillofacial Abnormalities (Congenital Abnormality)\tregulation of urea catabolic process (Organism Function)\tDisplacement of the male external urethral orifice (Abnormality of the urethra)\tBenign tumour of choroid plexus (Neoplastic Process)\tUZB (Language)", + "output": "Maxillofacial Abnormalities (Congenital Abnormality)" + }, + { + "input": "Definition: Bile Ducts, Extrahepatic described as the part of the common hepatic bile duct (tube that collects bile from the liver) that is outside the liver. This duct joins a duct from the gallbladder to form the common bile duct, which carries bile into the small intestine when food is being digested.\nConcepts: Anatomical barrier (Finding)\tForce-sensitive Electronic Probe (Medical Devices)\tNEUROL MODEL (Biological Models)\tnatural killer cell inhibitory signalling pathway (immune response-inhibiting cell surface receptor signaling pathway)\tBiliary System, Extrahepatic (Bile Ducts, Extrahepatic)", + "output": "Biliary System, Extrahepatic (Bile Ducts, Extrahepatic)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoma that arises from the breast and has spread to the lymph nodes.\nConcepts: Hospital Housekeepings (Health Care Activity)\tBreast Carcinoma Metastatic in Lymph Node (Neoplastic Process)\tPGM3 deficiency (Disease or Syndrome)\tFACT-BRM Version 4 - I Get Depressed Easily (Intellectual Product)\tCD2 Positive (Positive Laboratory Test Result)", + "output": "Breast Carcinoma Metastatic in Lymph Node (Neoplastic Process)" + }, + { + "input": "Definition: SPL Blood and Tissue Form Terminology described as terminology used to qualify the information pertaining to blood forms types of ownership in the framework of the Structured Product Labeling documents.\nConcepts: CDHF14 (FAT4 gene)\tImage Digitization Systems, Microscopy (Medical Device)\tStructured Product Labeling Blood Form Type of Ownership Terminology (Intellectual Product)\tSignaling (Function AND/OR dysfunction of axon)\tacetyl-CoA:N-acetylneuraminate 4-O-acetyltransferase activity (O-acetyltransferase activity)", + "output": "Structured Product Labeling Blood Form Type of Ownership Terminology (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-General Version 4 - Emotional Well-Being: I worry that my condition will get worse.\nConcepts: Urokinase-Derived Peptide A6 (Antineoplastic Biological Agent)\tFAC001-Worry My Condition Will Get Worse (FACT-G Version 4 Questionnaire Question)\tintrinsic to peroxisomal membrane (Cell Component)\tCarts, Central Supply, Orthopedic (Carts, Central Supply)\thaemorrhage conjunctiva (Other disorders of conjunctiva)", + "output": "FAC001-Worry My Condition Will Get Worse (FACT-G Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Neoplastic Process described as an ependymal tumor arising from the infratentorial region of the brain.\nConcepts: Cholylglycine (Laboratory Procedure)\tSchiller's Test (Diagnostic Procedure)\tBreast Myoepithelial Carcinoma (Invasive carcinoma of breast)\tInfratentorial Ependymal Tumor (Infratentorial Neoplasms)\tAnti-CD123/CD3 BiTE Antibody SAR440234 (Biologically Active Substance)", + "output": "Infratentorial Ependymal Tumor (Infratentorial Neoplasms)" + }, + { + "input": "Definition: something described as a group of tyrosine related oculocutaneous albinism (OCA1) that includes OCA1A, OCA1B, type 1 minimal pigment oculocutaneous albinism (OCA1-MP) and type 1 temperature sensitive oculocutaneous albinism (OCA1-TS). The phenotypic spectrum seen in OCA1 is variable. Pigmentation present in the skin, hair and eyes can range from little or none to pigmentation only to the peripheries. Findings of nystagmus, photophobia and reduced visual acuity are often present. The disease is caused by a mutation in the TYR gene located on chromosome 11q14.3 encoding tyrosinase. Mutations in OCA1A and OCA1B lead to a total or partial loss of the catalytic activity of tyrosinase while those in OCA1-MP and OCA1-TS lead to minimal activity or temperature sensitive tyrosinase proteins. The different forms of OCA1 are all transmitted autosomal recessively.\nConcepts: oculocutaneous albinism type 1 (Autosomal recessive hereditary disorder)\tPharmacology: Primary Pharmacodynamics (Regulation or Law)\tperif.nsrtd cntrl cath njxn (Injection procedure)\tNABTC (Health Care Related Organization)\tkidney tumor (Congenital anomaly of the kidney)", + "output": "oculocutaneous albinism type 1 (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: something described as the set of data generated by the subset of subjects who complied with the protocol sufficiently to ensure that these data would be likely to exhibit the effects of treatment according to the underlying scientific model.\nConcepts: cytidine to uridine editing (base conversion or substitution editing)\tDefinedCriterionGroupCompositionRelationship.sequenceNumber (Sequence Number)\tregulation of growth hormone activity (Molecular Function)\tProactive Inhibitions (Psychological inhibition)\tPer-Protocol Analysis Set (Data Set)", + "output": "Per-Protocol Analysis Set (Data Set)" + }, + { + "input": "Definition: something described as mild symptoms; intervention not indicated\nConcepts: Trabecular space network (Intra-osseous cavity of bone organ)\tLast Visit Seen With (Clinical Observation)\tGrade 1 Vagina hemorrhage (Finding)\thydrogen potassium ATPase (Hydrolase)\tmitochondrial LSU rRNA binding (Genetic Function)", + "output": "Grade 1 Vagina hemorrhage (Finding)" + }, + { + "input": "Definition: Protein Degradation, Regulatory described as the autophagy process which begins when chaperones and co-chaperones recognize a target motif and unfold the substrate protein. The proteins are then transported to the lysosome where they are degraded.\nConcepts: BP (Cardiac function)\tDistal Interphalangeal Joint 5 of the Foot (Body Part, Organ, or Organ Component)\tChaperone-Mediated Autophagy (Protein Degradation, Regulatory)\tAstatine At 211 Anti-CD45 Monoclonal Antibody BC8-B10 (Pharmacologic Substance)\tregulation of antimicrobial peptide secretion (regulation of peptide secretion)", + "output": "Chaperone-Mediated Autophagy (Protein Degradation, Regulatory)" + }, + { + "input": "Definition: something described as a thin layer of tissue that forms the anterior wall of the cochlear duct, which separates it from the vestibular canal.\nConcepts: Membrana vestibularis ductus cochlearis (Tissue membrane)\tpresbyacusia (hearing impairment)\t12q14-q15 (Cell Component)\tguanine aminase activity (deaminase activity)\tSelective Estrogen Receptor Degrader LSZ102 (Pharmacologic Substance)", + "output": "Membrana vestibularis ductus cochlearis (Tissue membrane)" + }, + { + "input": "Definition: Epidermal growth factor measurement described as a measurement of the unbound epidermal growth factor in a peripheral blood-derived specimen.\nConcepts: chemoimmunotherapy (Therapeutic or Preventive Procedure)\tNightshades, Black (Solanaceae)\tCirculating Epidermal Growth Factor Measurement (Epidermal growth factor measurement)\tmetanephric juxtaglomerulus cell differentiation (juxtaglomerulus cell differentiation)\tDesvenlafaxine Measurement (Laboratory Procedure)", + "output": "Circulating Epidermal Growth Factor Measurement (Epidermal growth factor measurement)" + }, + { + "input": "Definition: Agent Affecting Respiratory System described as any agent that promotes ejection of mucus or exudate from the lungs, bronchi and trachea by decreasing mucus viscosity or by increasing the secretion of mucus in a dry, unproductive cough.\nConcepts: Phase of Labor (Finding During Childbirth Labor)\tIllusory auras (Experiential auras)\tHippocampal Mossy Fibers (Axon)\tSGRQ01-Afraid When Cannot Catch Breath (Intellectual Product)\texpectorant agents (Cough AND/OR decongestant agent)", + "output": "expectorant agents (Cough AND/OR decongestant agent)" + }, + { + "input": "Definition: Neurotransmitter Receptor described as cell-surface proteins that bind histamine and trigger intracellular changes influencing the behavior of cells. Histamine receptors are widespread in the central nervous system and in peripheral tissues. Three types have been recognized and designated H1, H2, and H3. They differ in pharmacology, distribution, and mode of action.\nConcepts: Histamine receptor (receptor)\tASV (SRC gene)\tImmediate Percutaneous Coronary Intervention for ST Elevation Myocardial Infarction (Therapeutic or Preventive Procedure)\tR3601-I Am as Healthy as Anybody I Know (Intellectual Product)\tCrypt abscesses (Acute inflammation)", + "output": "Histamine receptor (receptor)" + }, + { + "input": "Definition: endoplasmic reticulum mannose trimming described as the removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.\nConcepts: RNP antibody, immunodiffusion or other method (ENA: extractable nuclear antigen antibody)\tPhorbol esters (Ring Compound)\tglycoprotein mannose trimming on C branch (Molecular Function)\tQSTPTNUM (Planned Time Point Number)\tELK (Gene or Genome)", + "output": "glycoprotein mannose trimming on C branch (Molecular Function)" + }, + { + "input": "Definition: Disease or Syndrome described as genetic disorder that produces tall and in many cases disturbed behavioral males due to XYY karyotype.\nConcepts: Chromosome Arm 9p Loss of Heterozygosity (Cell or Molecular Dysfunction)\tRucaparib Camsylate (R [Preparations])\tXYY SYNDROME (Anomaly of chromosome Y)\tMultiple suture craniosynostosis (Finding)\tSummary (Min) Ventricular Rate (Ventricular Heart Rate)", + "output": "XYY SYNDROME (Anomaly of chromosome Y)" + }, + { + "input": "Definition: BPI Short Form Questionnaire Question described as brief Pain Inventory Short Form (BPI Short Form) Circle the one number that describes how, during the past 24 hours, pain has interfered with your walking ability.\nConcepts: Kluyvera species (Kluyvera)\tIrregular myelin loops (Anatomical Abnormality)\tFeel Worn Out or Sluggish (Intellectual Product)\tPostcentral sulcus of island (Set of subarachnoid sulci)\tBPI209C (BPI Short Form Questionnaire Question)", + "output": "BPI209C (BPI Short Form Questionnaire Question)" + }, + { + "input": "Definition: something described as cannulae designed to be inserted into the cranium, providing access to the brain (e.g., for a therapeutic or diagnostic procedure). These cannulae are typically short, rigid or semirigid, plastic, or less frequently, metallic tubes. Intracranial cannulae are frequently connected directly or via an external tube or catheter to an irrigator and/or aspirator for irrigation, infusion, or withdrawal of substances. Intracranial cannulae may also provide a port through which instruments and/or probes are passed to perform a variety of diagnostic, treatment, or surgical procedures.\nConcepts: JELLY, CONTACT, FOR TRANSURETHRAL SURGICAL INSTRUMENT (Medical Device)\tAlpha-gal syndrome (Pathologic Function)\tIntracranial cannula (Surgical drains and associated device)\tSH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS 2 (Adaptor Signaling Protein Gene)\tRAND-36 - Physical Health Difficulty Performing Work (RAND-36 Questionnaire Question)", + "output": "Intracranial cannula (Surgical drains and associated device)" + }, + { + "input": "Definition: Perodactylia described as the absence of all phalanges of all the digits of a limb and the associated soft tissues.\nConcepts: PSA Level Greater than One (PSA Level Finding)\tHepatic Pain, CTCAE (Finding)\tPineal Parenchyma (Tissue)\tapoptotic cell death involved in anatomical structure development (Cell Function)\tAphalangy (Congenital anomaly of digit)", + "output": "Aphalangy (Congenital anomaly of digit)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a purine nucleobase with an amine group attached to the carbon at position 6. Adenine is the precursor for adenosine and deoxyadenosine nucleosides.\nConcepts: LEC01-Assault With a Weapon: Learned (Intellectual Product)\tIris Melanoma pT3 TNM Finding v8 (Iris Melanoma Pathologic Primary Tumor TNM Finding v8)\tVitamin B 4 (nucleobase)\tYolk sac (Embryo, Nonmammalian)\tLIGHT, SURGICAL, INSTRUMENT (Medical Device)", + "output": "Vitamin B 4 (nucleobase)" + }, + { + "input": "Definition: Methyltransferase described as histone-lysine N-methyltransferase SUV39H1 (412 aa, ~48 kDa) is encoded by the human SUV39H1 gene. This soluble, nuclear protein plays a role in establishment of constitutive heterochromatin at pericentric and telomeric regions. Trimethylation of H3K9 is also required to direct DNA methylation at pericentric repeats.\nConcepts: \"Technologists, Technicians & Other Technical Service Providers\"; \"Technician, Pathology\" (Professional or Occupational Group)\t107 kDa Retinoblastoma-Associated Protein (Amino Acid, Peptide, or Protein)\tdeoxyribonucleotide biosynthetic process (Nucleotide Biosynthesis)\tSu(var)3-9 homolog 1 (Amino Acid, Peptide, or Protein)\tSterile Alpha and TIR Motif Containing 1 wt Allele (Gene or Genome)", + "output": "Su(var)3-9 homolog 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a response indicating that this is an individual's first visit to the clinic.\nConcepts: Vaginal Cancer FIGO Stage II (Vaginal Cancer pT2 TNM Finding v8)\tupregulation of protein oligomerization (Cell Function)\tRenal CL Norm by Dose (Renal clearance diagnostic test)\tIVD Test Reagent/Kits, Immunoassay, Endocrine Hormone, Growth Hormone (Medical Device)\tThis is my first visit to this clinic (Clinical or Research Assessment Answer)", + "output": "This is my first visit to this clinic (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as inability to smell.\nConcepts: anosmia (Finding)\tfatal post-viral neurodegenerative disorder (Inflammation of specific body organs)\tbeta Keratins (Amino Acid, Peptide, or Protein)\ttranslocation robertsonian (Chromosomal translocation)\t62Cu-ATSM (Radioconjugate)", + "output": "anosmia (Finding)" + }, + { + "input": "Definition: oxygen described as triatomic form of oxygen, O3; a pungent, unstable blue gas that in the upper atmosphere forms a protective layer against excess ultraviolet radiation and is an ingredient of photochemical smog in the lower atmosphere; used in the purification of drinking water and as an oxidizing agent.\nConcepts: acarbose (A [Preparations])\tmosaic trisomy 14 (Rare Non-Neoplastic Disorder)\tOZONE (Oxygen Compounds, Unspecified)\tAbnormal synaptic transmission (Abnormal nervous system physiology)\tBile duct adenocarcinoma resectable (Bile duct adenocarcinoma)", + "output": "OZONE (Oxygen Compounds, Unspecified)" + }, + { + "input": "Definition: nephron epithelium development described as the process whose specific outcome is the progression of the metanephric nephron epithelium over time, from its formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure. The metanephric nephron epithelium is a tissue that covers the surface of a nephron in the metanephros.\nConcepts: Absent/hypoplastic metatarsals (Aplasia/Hypoplasia involving bones of the feet)\tmetanephric nephron epithelium development (nephron epithelium development)\tgamma-tubulin complex localization to mitotic SPB (protein localization to mitotic spindle pole body)\tI don't look like myself (Intellectual Product)\tContusion, Myocardial (Bruising, ecchymosis and purpura)", + "output": "metanephric nephron epithelium development (nephron epithelium development)" + }, + { + "input": "Definition: Nose described as distance from nasion to subnasale more than two standard deviations above the mean, or alternatively, an apparently increased length from the nasal root to the nasal base.\nConcepts: Elongated nose (Nose)\tBody posture chart (Complementary therapy device)\tgynaecologists (Professional or Occupational Group)\tSplenic Lymphoma with Circulating Villous Lymphocytes (B-cell lymphoma morphology)\tActivin Receptor Like Kinases, Type II (Activin Receptor)", + "output": "Elongated nose (Nose)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIIC includes: (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.\nConcepts: Rhaphidophora (Plant)\toidium formation (asexual sporulation)\tElectrothermal Cautery Units, High-Resistance (Electrothermal Cautery Units)\tmalignant neoplasm of large intestine stage IIIc (Stage IIIC Colorectal Cancer AJCC v7)\tnegative regulation of leaf senescence (negative regulation of leaf development)", + "output": "malignant neoplasm of large intestine stage IIIc (Stage IIIC Colorectal Cancer AJCC v7)" + }, + { + "input": "Definition: Uricosuric Agents described as a phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs. In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.\nConcepts: FAC016-Trouble Meeting Needs of Family (FACT-L Version 4 Questionnaire Question)\tSulfinpyrazone (phenylbutazone)\tRegulatory Application (Application)\tCO2 Level at Organ Excision Time (CPTAC Questions)\tStage IIIB Gestational Trophoblastic Tumor AJCC v7 (Stage III Gestational Trophoblastic Tumor AJCC v7)", + "output": "Sulfinpyrazone (phenylbutazone)" + }, + { + "input": "Definition: something described as the process in which a relatively unspecialized cell acquires specialized features of a Malpighian tubule stellate cell. A Malpighian tubule stellate cell is a specialized epithelial secretory cell that moves chloride ions and water across the tubule epithelium.\nConcepts: PARTICLE-ENHANCED TURBIDIMETRIC IMMUNOASSAY (Laboratory Procedure)\tdown regulation of cellular alcohol catabolic process (regulation of cellular alcohol catabolic process)\tRubrobulbar tract (Cerebral tracts)\tBase R TZa (Structure of anterior section of prostate)\tMalpighian tubule stellate cell differentiation (Cell Function)", + "output": "Malpighian tubule stellate cell differentiation (Cell Function)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline.\nConcepts: HPV Messenger Ribonucleic Acid (RNA, Messenger)\toctopine degradation to proline (proline metabolic process)\tendomyocardial fibrosis (Endocardial disorders NEC)\tSuberites (Eukaryote)\tGnathostoma species (Tissue nematode)", + "output": "octopine degradation to proline (proline metabolic process)" + }, + { + "input": "Definition: Intellectual Product described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) During the past month, I have been: Worrying that my teen doesn't have the right doctor for him/her.\nConcepts: Exocrine Pancreatic Cancer pT4 TNM Finding v8 (Exocrine Pancreatic Cancer Pathologic Primary Tumor TNM Finding v8)\tD-sorbitol:(acceptor) 1-oxidoreductase activity (Molecular Function)\tDDS0211 (PARENT-DDS Questionnaire Question)\tLiposome-encapsulated OSI-7904 (Thymidylate synthase inhibitor)\tX-linked mental retardation 27 (Disease or Syndrome)", + "output": "DDS0211 (PARENT-DDS Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as an integer specifying the relative sequential or temporal ordering of this relationship among other similar relationships having the same source. EXAMPLE(S): In a problem set, this may incidate the relative order of a series of images and/or observations. OTHER NAME(S): NOTE(S):\nConcepts: PerformedActivityRelationship.sequenceNumber (Sequence Number)\tcoriander oil@@MISCELL@OIL (Oils, Volatile)\tNormal pregnancy conditions and outcomes (Classification)\tperiostitis; monomelic (Bone Diseases)\tSTAINS, DYE SOLUTION (Medical Device)", + "output": "PerformedActivityRelationship.sequenceNumber (Sequence Number)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: UDP-alpha-D-glucose + coniferyl aldehyde = H+ + coniferaldehyde glucoside + UDP.\nConcepts: Rod Cell (Neuroanatomy)\tCarbonic Anhydrase Isozyme V (Enzyme)\tCefamandole (C [Preparations])\tUDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity (Molecular Function)\t3-oxothiolase activity (acetyl-CoA C-acyltransferase activity)", + "output": "UDP-glucose:coniferaldehyde 4-beta-D-glucosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measure to quantify the number of rectangular areas in a city surrounded by streets.\nConcepts: Large head (Head)\tpositive regulation of initiation of acetate catabolic process by acetate (Cell Function)\tolfactory bulb interneuron fate commitment (neuron fate commitment)\tSRPUL (Gene or Genome)\tBLOCKS (Quantitative Concept)", + "output": "BLOCKS (Quantitative Concept)" + }, + { + "input": "Definition: pigment granule localization described as the directed movement of pigment granules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: wakerobin (Western herbs and natural substances letter T)\tNot done (Qualitative Concept)\tTarget Audience (Group)\tpigment granule transport (Biological Transport)\tPerformed Specimen Move Temperature (Quantitative Concept)", + "output": "pigment granule transport (Biological Transport)" + }, + { + "input": "Definition: Widened subarachnoid space described as an increase in size of the anatomic space between the arachnoid membrane and pia mater in the region surrounding the cerebrum.\nConcepts: Grade 3 Ileum ulcer (Ileal Ulcer, CTCAE)\tWidened cerebral subarachnoid space (Widened subarachnoid space)\ttRNA (adenine-C2-)-methyltransferase activity (C-methyltransferase activity)\tCONSOLIDATION (Health Care Related Organization)\tReader 2 (Occupation or Discipline)", + "output": "Widened cerebral subarachnoid space (Widened subarachnoid space)" + }, + { + "input": "Definition: oxo-acid-lyase activity described as catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate.\nConcepts: hydroxyketoglutaric aldolase activity (aldehyde-lyase activity)\tKRAS2 c.39C>T (Cell or Molecular Dysfunction)\tCranial nerve-tract complex (Neural tree organ)\tVelcade-Cyclophosphamide-Dexamethasone (Therapeutic or Preventive Procedure)\tPQL1404 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)", + "output": "hydroxyketoglutaric aldolase activity (aldehyde-lyase activity)" + }, + { + "input": "Definition: Abnormal liver morphology described as a structural anomaly of the liver located predominantly in the hepatocytes as opposed to stromal cells.\nConcepts: Abnormal liver parenchyma morphology (Abnormal liver morphology)\tquisqualis indicae/shi jun z (Plant)\tmidbody abscission (mitotic cytokinetic process)\tWashers, Large Equipment, Wheelchair (Manufactured Object)\tFeeding assessment (Common nursing interventions)", + "output": "Abnormal liver parenchyma morphology (Abnormal liver morphology)" + }, + { + "input": "Definition: Peripheral neurophysiological feature described as lowest stimulus intensity a subject can detect or that can elicit a sensory response.\nConcepts: sensory threshold (Quantitative Concept)\tOriental herb and/or natural substance preparation training individual each 15 minutes (Preparing and/or dispensing and/or training services with or without ICD diagnosis)\t{Caplet} (Quantitative Concept)\tSponge (Contraceptive Devices)\tL-hydroxyproline transmembrane transporter activity (modified amino acid transmembrane transporter activity)", + "output": "sensory threshold (Quantitative Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as agents that are administered in association with anesthetics to increase effectiveness, improve delivery, or decrease required dosage.\nConcepts: School Racial Segregation (Social Behavior)\tStage IB Carcinoma of the Stomach (Malignant neoplasm of stomach stage I)\tAnesthesia adjuvants (Pharmacologic Substance)\tDriving animal-powered vehicles (Automobile Driving)\tOlfactory Epithelial Cells (Epithelial Cells)", + "output": "Anesthesia adjuvants (Pharmacologic Substance)" + }, + { + "input": "Definition: Hemangioma described as a vascular lesion in the papillary dermis resulting from ectasia of pre-existing vessels. It is associated with secondary proliferative changes in the overlying epidermis (hyperkeratosis). It can present with widespread lesions (angiokeratoma corporis diffusum, often associated with inborn errors of metabolism) or as a localized lesion (angiokeratoma of Fordyce, angiokeratoma circumscriptum, and angiokeratoma of Mibelli).\nConcepts: angiokeratoma (Blood Vessel Tumors)\tLiter per Minute per Microgram per Meter Squared (Quantitative Concept)\tPaper Towels (Manufactured Object)\tTrypsin Inhibitor, Kazal Pancreatic (Proteins)\tHydrops Fetalis Nonimmunes (Hydrops Fetalis)", + "output": "angiokeratoma (Blood Vessel Tumors)" + }, + { + "input": "Definition: something described as an artery arising from the celiac trunk with four main branches that supply the spleen, stomach and pancreas.\nConcepts: formamide hydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tXq22.2 (Cell Component)\t13q22-q34 (Chromosome band)\tArteries, Splenic (Celiac Artery)\t8-Methyl-N-Vanillyl-6-Nonenamide (Alkylamide)", + "output": "Arteries, Splenic (Celiac Artery)" + }, + { + "input": "Definition: something described as the reactivation of latent hepatitis C infection usually caused by a medicinal agent, such as an immunosuppressant.\nConcepts: Dystrophia Smolandiensis (Disease or Syndrome)\toleate transmembrane transporter activity (Molecular Function)\tReactivation of hepatitis C viral hepatitis (Recurrent viral infection)\tCHAMBER, SLIDE CULTURE (Medical Device)\tCystoviridae (Bacteriophages)", + "output": "Reactivation of hepatitis C viral hepatitis (Recurrent viral infection)" + }, + { + "input": "Definition: Vitamin described as derivatives of ERGOSTEROL formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. They differ from CHOLECALCIFEROL in having a double bond between C22 and C23 and a methyl group at C24.\nConcepts: blood group b (Laboratory or Test Result)\tErgocalciferols (Vitamin)\tNanophthalmia (Microphthalmos)\tFAC071-Enjoy Things I Usually Do for Fun (FACIT-F Version 4 Questionnaire Question)\tbranched chain acyl CoA synthetase (ADP-forming) activity (acid-thiol ligase activity)", + "output": "Ergocalciferols (Vitamin)" + }, + { + "input": "Definition: Polymerase Chain Reaction described as a laboratory procedure that analyzes the genetic profile of the T-cell receptor variable complementary determining region 3 (CDR3) for an individual. The genetic sequence for CDR3 is amplified using the polymerase chain reaction and specific primers.\nConcepts: Complementary Determining Region 3 Spectratyping (Laboratory Procedure)\tprotein K63-linked deubiquitination (Deubiquitination)\th*ug/mL/m2 (Measurement Unit Description)\tstage II lymphoblastic childhood lymphoma (Ann Arbor Stage II Childhood Non-Hodgkin Lymphoma)\tstenosis; duodenum (Duodenal Obstruction)", + "output": "Complementary Determining Region 3 Spectratyping (Laboratory Procedure)" + }, + { + "input": "Definition: Diagnostic Procedure described as an observation that generates a recording made from energy of the light spectrum\nConcepts: Inferior radiation of thalamus (Body Part, Organ, or Organ Component)\tterminology (Thesaurus of Psychological Index Terms)\tmonocarboxylate:sodium symporter activity (Molecular Function)\tMedical photography of patient (Evaluation procedure)\tFaucial diphtheria (Infectious disease of mucous membrane)", + "output": "Medical photography of patient (Evaluation procedure)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as preliminary administration of a drug preceding a diagnostic, therapeutic, or surgical procedure. The commonest types of premedication are antibiotics (ANTIBIOTIC PROPHYLAXIS) and anti-anxiety agents. It does not include PREANESTHETIC MEDICATION.\nConcepts: Very much bothered (Clinical or Research Assessment Answer)\tpres meds (Therapeutic procedures NEC)\tChemical Or Drug Affects Cell Type Or Tissue (NCI Thesaurus Role)\tmedulla oblongata maturation (Organ or Tissue Function)\tneuron migration involved in retrograde extension (neuron migration)", + "output": "pres meds (Therapeutic procedures NEC)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-35.\nConcepts: Radiant Warmer, Infant (Medical Device)\tupregulation of interleukin-35 biosynthetic process (regulation of interleukin-35 biosynthetic process)\tCan Do With Some Difficulty (Finding)\tHow Much Did Ringing, Buzzing, Whistling Noises Interfere with Your Daily Activities (Intellectual Product)\tMedical Device Explosion Issue (Finding)", + "output": "upregulation of interleukin-35 biosynthetic process (regulation of interleukin-35 biosynthetic process)" + }, + { + "input": "Definition: Finding described as intrahepatic bile duct cancer with tumor perforating the visceral peritoneum.\nConcepts: (+)-secoisolariciresinol monoglucoside glucosyltransferase activity (Molecular Function)\tSyndecan-2 (Amino Acid, Peptide, or Protein)\t3-oxoacyl-CoA hydrolase activity (Molecular Function)\tDDP-MECY Regimen (Regimen Used to Treat Malignant Ovarian Neoplasm)\tIntrahepatic Bile Duct Cancer pT3 TNM Finding v8 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v8)", + "output": "Intrahepatic Bile Duct Cancer pT3 TNM Finding v8 (Intrahepatic Bile Duct Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Coping Assistance described as facilitating the patient to perceive, appreciate, and express what is funny, amusing, or ludicrous in order to establish relationships, relieve tension, release anger, facilitate learning, or cope with painful feelings\nConcepts: Mole per Liter per Milligram per Kilogram (Quantitative Concept)\tTrypan Blue Staining Method (Staining method)\tHumour facilitation (Therapeutic or Preventive Procedure)\tHEMOPEXIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tTVVCW (Cardiovascular finding)", + "output": "Humour facilitation (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: positive regulation of organelle assembly described as any process that activates or increases the frequency, rate or extent of gut granule assembly.\nConcepts: NVTPTREF (Temporal Concept)\tBupropion product (Ketones)\tHypothalamic dysgenesis (Abnormal hypothalamus morphology)\tup-regulation of gut granule formation (Cell Function)\tperipheral pulmonary stenosis (Disorder of pulmonary circulation)", + "output": "up-regulation of gut granule formation (Cell Function)" + }, + { + "input": "Definition: something described as providing reassurance to a patient while remaining consistent with his or her religious beliefs. Service is billed in 15-minute increments.\nConcepts: planar cell polarity pathway involved in neural tube closure (Wnt signaling pathway, planar cell polarity pathway)\tIris hamartoma (Benign neoplasm of eye, unspecified)\tNitroreductases (Enzyme)\tsprtlnrse resrnc ea.15min (Spiritual nursing care)\tcellular response to amiloride (Cell Function)", + "output": "sprtlnrse resrnc ea.15min (Spiritual nursing care)" + }, + { + "input": "Definition: Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene described as chronic lymphocytic leukemia characterized by the absence of somatic hypermutation within the immunoglobulin heavy chain gene variable region of neoplastic clones. Patients have a significantly worse prognosis as compared to those with mutated immunoglobulin heavy chain gene variable region rearrangements.\nConcepts: Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene (Neoplastic Process)\tBacteriochlorophyll A (Organic Chemical)\tsocitl/rnvrnmntl cpng asistn (Health Care Activity)\tBRCA2-MAGE-D1 complex (Cell Component)\tKlapping (Osteopathic manipulation)", + "output": "Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene (Neoplastic Process)" + }, + { + "input": "Definition: something described as combination of masculine and feminine personality characteristics in one individual.\nConcepts: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine (Molecular Function)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2 Assessment of Premature Preterm Rupture of Membranes (GAIA Premature Preterm Rupture of Membranes Levels of Diagnostic Certainty)\tSMDDS Version 1.0 - How Much Feel Like Doing Nothing (Intellectual Product)\tExtent of Problems Opening Mouth Wide (Clinical or Research Assessment Question)\tandrogyny (Gender Identity)", + "output": "androgyny (Gender Identity)" + }, + { + "input": "Definition: Qualitative Concept described as multi-step systematic review process used for improving safety by investigation of incidents to find what happened, why it happened, and to determine what can be done to prevent it from happening again.\nConcepts: Scissors, Surgical, Vascular, Microsurgery (Medical Device)\tAnalysis, Root Cause (Qualitative Concept)\t5-ht agonists (Agent Affecting Nervous System)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, FOXG1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tStage III Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma (Adult Burkitt Lymphoma)", + "output": "Analysis, Root Cause (Qualitative Concept)" + }, + { + "input": "Definition: DNA repair protein described as 40S ribosomal protein S3 (243 aa, ~27 kDa) is encoded by the human RPS3 gene. This protein plays a role in translation and DNA repair.\nConcepts: positive regulation of mRNA decay (positive regulation of cellular catabolic process)\tEC 4.2.99.18 (DNA repair protein)\tcoronary (artery) thrombosis (Arterial thrombosis)\tdeoxyuridine synthesis (Molecular Function)\tSOAPP-R - Others Suggested Drug or Alcohol Problem (Intellectual Product)", + "output": "EC 4.2.99.18 (DNA repair protein)" + }, + { + "input": "Definition: Affective seizure described as focal emotional seizure with agitation is characterized by the presence of psychomotor agitation as an expressed or observed emotion, at the outset of the seizure. Because of the unpleasant nature of these seizures, patients may also have anticipatory anxiety about having seizures.\nConcepts: Personnel Staffing/Scheduling Information Systems (Intellectual Product)\tFocal emotional seizure with agitation (Affective seizure)\tS-Adenosyl-Methionine Decarboxylase Inhibitor (Enzyme Inhibitor Drugs)\tManaging unexpected events related to your child's illness (Intellectual Product)\tglycosyl compound metabolism (carbohydrate derivative metabolic process)", + "output": "Focal emotional seizure with agitation (Affective seizure)" + }, + { + "input": "Definition: Structural protein described as general receptor for phosphoinositides 1-associated scaffold protein (395 aa, ~43 kDa) is encoded by the human GRASP gene. This protein plays a role in the localization of cell surface receptors.\nConcepts: Burns unit (Location within hospital premises)\t14q11.1-q11.2 (Chromosome band)\tNot True at All (Finding)\tSignet ring sign (Abnormal pulmonary thoracic imaging finding)\tGRASP protein, human (Biologically Active Substance)", + "output": "GRASP protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Stage 0a Renal Pelvis and Ureter Cancer AJCC v7 described as stage 0a includes: Ta, N0, M0. Ta: Papillary noninvasive carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Mediastinal/Thymic NMC (Thoracic NUT Carcinoma)\tStage 0a Ureteral Carcinoma (Stage 0 Ureter Cancer AJCC v7)\tCentral line (Vascular Access Devices)\ttyramines (Biogenic Monoamines)\tFluorescence Intensity (Quantitative Concept)", + "output": "Stage 0a Ureteral Carcinoma (Stage 0 Ureter Cancer AJCC v7)" + }, + { + "input": "Definition: something described as a protein complex, located in the nucleus, that possesses DNA-directed RNA polymerase activity.\nConcepts: Proto-Oncogene Protein, fos (Amino Acid, Peptide, or Protein)\tnuclear DNA-directed RNA polymerase complex (DNA-directed RNA polymerase complex)\tpathologic stage 0 Merkel cell carcinoma AJCC v8 (stage, Merkel cell carcinoma)\tPTTG (Body Part, Organ, or Organ Component)\tCASP8AP2 gene (Gene or Genome)", + "output": "nuclear DNA-directed RNA polymerase complex (DNA-directed RNA polymerase complex)" + }, + { + "input": "Definition: something described as the mean cell volume is the average volume of a red blood cell. This is a calculated value derived from the hematocrit and the red cell count.\nConcepts: Orientation: Season (ADAS-Cog CDISC Version Questionnaire Question)\tNanocephaly (Congenital anomaly of brain)\tUndefined homeopathic remedy letter S narrative required (Pharmacologic Substance)\tErythrocyte Mean Corpuscular Volume Measurement (Erythrocyte Indices)\t1-AGP Acyltransferase 8 (Amino Acid, Peptide, or Protein)", + "output": "Erythrocyte Mean Corpuscular Volume Measurement (Erythrocyte Indices)" + }, + { + "input": "Definition: Finding described as appendiceal carcinoma with tumor invading through the muscularis propria into the subserosa or the mesoappendix.\nConcepts: Familial Male Precocious Puberty (Finding)\ttechnology/technique development (technology/technique)\tAppendiceal Carcinoma pT3 TNM Finding v8 (Appendiceal Carcinoma Pathologic Primary Tumor TNM Finding v8)\tCMKBRL2 (Gene or Genome)\tMonostotic fibrous dysplasia [dup] (Other disorders of bone density and structure)", + "output": "Appendiceal Carcinoma pT3 TNM Finding v8 (Appendiceal Carcinoma Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Germinomatous Germ Cell Tumor described as the presence of a dysgerminoma, i.e., an undifferentiated germ cell tumor of the ovary.\nConcepts: Intramammary emulsion (Biomedical or Dental Material)\tLymphocytic cell (Leukocytes)\tCalcifediol anhydrous (Vitamin D Analog)\tdysgerminomas (Primary malignant neoplasm)\tProto-Oncogene Tyrosine-Protein Kinase ROS Measurement (Protein or Enzyme Type Measurement)", + "output": "dysgerminomas (Primary malignant neoplasm)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow graft from a donor may reduce the chance of an immune reaction against the recipient's tissues.\nConcepts: Clue Cells (Laboratory Procedure)\tdetection of host (response to host)\tT-cell depletion (Therapeutic immunosuppression)\tundescended testicle unilateral (Finding with explicit context)\tADL0102 (ADCS-ADL Questionnaire Question)", + "output": "T-cell depletion (Therapeutic immunosuppression)" + }, + { + "input": "Definition: Professional or Occupational Group described as graduate-prepared clinical specialists in Medical-Surgical Nursing provide care for individuals who have a known or predicted physiological alteration. Clinical specialists demonstrate an in-depth understanding of complex medical-surgical problems, as well as interventions to manage and improve patient care. Guided by theory and research, their practice considers all influences on health status and the related social and behavioral problems arising because of the patient's physiological condition. Clinical specialists are engaged in education, case management, expert clinical practice, consultation, research, and administration. Clinical specialists practice in settings where primary, acute, or long-term nursing care is delivered.\nConcepts: iTRAQH (Isobaric Tags for Relative and Absolute Quantitation)\tMedical-Surgical Nurse Specialist (Clinical Nurse Specialists)\tDigital ulcer (Disease or Syndrome)\tPHOTOGRAPHY (Investigative Techniques)\tOvotestis (Ovary finding)", + "output": "Medical-Surgical Nurse Specialist (Clinical Nurse Specialists)" + }, + { + "input": "Definition: Spatial Concept described as physical location of CST6_Gene\nConcepts: cyanogenic glycoside synthesis (cyanogenic glycoside metabolic process)\tnucleus PV-PT (Body Part, Organ, or Organ Component)\tInternational Classification of Diseases, Tenth Revision (Code System)\tmetastasis to ovary (Secondary Neoplasm)\t11: 65536038-65537552 (Spatial Concept)", + "output": "11: 65536038-65537552 (Spatial Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.\nConcepts: TESTIS/EPIDIDYMIS (Tissue specimen)\tHas CDRH Parent (Intellectual Product)\tLUNG WITH HEART-SHIELDED IRRADIATION (Therapeutic or Preventive Procedure)\tspondylometaphyseal dysplasia, X-linked (Congenital anomaly of skeletal bone)\tDrug, Investigational New (Agent)", + "output": "Drug, Investigational New (Agent)" + }, + { + "input": "Definition: Molecular Function described as any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin.\nConcepts: positive regulation of auxin mediated signalling pathway (Molecular Function)\tEpirubicin hydrochloride (epirubicin)\tAnti-emetics (Gastrointestinal Agents)\tNon-Small Cell Cancer of the Lung (Carcinoma of lung)\tIPATASERTIB (Organic Chemical)", + "output": "positive regulation of auxin mediated signalling pathway (Molecular Function)" + }, + { + "input": "Definition: catechin described as a catechin with the R configuration at C-2 and C-3.\nConcepts: Retinal nerve fibre oedema (Pathologic Function)\t(-)-Epicatechol (Pharmacologic Substance)\tpT2 Carcinoma of Ovary v6 (Finding)\tHOSP VETERANS (Health Care Related Organization)\tM (Antidote)", + "output": "(-)-Epicatechol (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as occurring during or associated with a surgical procedure.\nConcepts: Grade 3 Skin ulceration (Skin Ulceration, CTCAE)\tRECOMBINATION GENET (GENE-RELATED PHENOMENA)\tAdjuvant Radiation Therapy (Therapeutic radiology procedure)\tOperative (Temporal Qualifier)\tTolmetin product (Pyrroles)", + "output": "Operative (Temporal Qualifier)" + }, + { + "input": "Definition: Fusion Gene described as a fusion gene that results from a chromosomal translocation t(2;13)(q35;q14) which fuses intron 1 of the FOXO1 gene with intron 7 of the PAX3 gene. This rearrangement is associated with alveolar rhabdomyosarcoma.\nConcepts: PQL0503 (PedsQL Neuromuscular Module Version 3.0 Child Report Questionnaire Question)\tIVD Test Reagent/Kits, Cytology/Histology, Antisera, Polyvalent (Medical Device)\tFKHR-PAX3 Fusion Gene (Fusion Gene)\tPQL0525 (PedsQL Neuromuscular Module Version 3.0 Child Report Questionnaire Question)\tRespiratory function, NOS (Taking vital signs)", + "output": "FKHR-PAX3 Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Intellectual Product described as the formal plan of an experiment or research activity, including the objective, rationale, design, materials and methods for the conduct of the study; intervention description, and method of data analysis.\nConcepts: R8 cell differentiation (compound eye photoreceptor cell differentiation)\ttraumatic neurosis (Mental or Behavioral Dysfunction)\tBlastula (Embryonic Structure)\tCarbuncle (Carbuncle of skin and/or subcutaneous tissue)\tProtocol (Protocols documentation)", + "output": "Protocol (Protocols documentation)" + }, + { + "input": "Definition: Bacterial Infections described as infection of the LIVER with species of MYCOBACTERIUM, most often MYCOBACTERIUM TUBERCULOSIS. It is characterized by localized small tuberculous miliary lesions or tumor-like mass (TUBERCULOMA), and abnormalities in liver function tests.\nConcepts: Tuberculosis of liver (Hepatitis due to infection)\tPCV-13 vaccine (Pneumococcal vaccine)\tCredit and Collection, Patient (Health Care Activity)\tMicrosomal Glutathione S-Transferase 2 wt Allele (Gene or Genome)\tBrain syndrome acute (Altered thought processes)", + "output": "Tuberculosis of liver (Hepatitis due to infection)" + }, + { + "input": "Definition: Finding described as lung cancer in which the primary tumor cannot be assessed.\nConcepts: Irregular epiphysis of the distal phalanx of the 2nd finger (Anatomical Abnormality)\tSANDO (sensory ataxic neuropathy dysarthria ophthalmoparesis) syndrome (Autosomal recessive hereditary disorder)\tStage III Oropharyngeal Throat Cancer (Stage III Pharynx Carcinoma)\tLung Cancer pTX TNM Finding v8 (Lung Cancer Pathologic Primary Tumor TNM Finding v8)\tSemi-Fowlers ( SubjectBodyPosition)", + "output": "Lung Cancer pTX TNM Finding v8 (Lung Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Code System described as a segmented numeric drug code assigned by Medi-Span, using a hierarchical classification scheme encompassing drug group, class, sub-class, name, name extension and dosage. Products assigned the same code should be pharmaceutically equivalent regarding active ingredients, dose form, route of administration, and strength. The same drug may be classified in multiple therapeutic classes.\nConcepts: UDP-D-galacturonate metabolism (Molecular Function)\tarachidoyl-CoA:1-dodecanol O-acyltransferase activity (Molecular Function)\tPRO Stem (Intellectual Product)\tGPI (CodeSystem)\tVestibular nerve (vestibular nervous system)", + "output": "GPI (CodeSystem)" + }, + { + "input": "Definition: Intellectual Product described as solitary tumor, smaller than 4 disc diameters, tumor at or behind the equator.\nConcepts: Sigmoid Mesocolon Hernia (Hernia of abdominal cavity)\tCTX/5-FU/FXM/MTX (Therapeutic or Preventive Procedure)\tAcromelia of the lower limbs (Acromelia)\tReese-Ellsworth IA (Intellectual Product)\tUncaria tomentosa / cat's claw (Pharmacologic Substance)", + "output": "Reese-Ellsworth IA (Intellectual Product)" + }, + { + "input": "Definition: Activity described as conveyance or shipment of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps) that has met all release criteria.\nConcepts: HCT/P Distribution (Activity)\tstaphylococcus xylosus (Staphylococcus, coagulase negative)\tSuradista (Distamycins)\tWide mouth (congenital anomalies of face and neck)\tNon-Sterile Vibratory Powder Filling Method (Laboratory Procedure)", + "output": "HCT/P Distribution (Activity)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual tried and failed to control, cut down, or stop using an opioid medication.\nConcepts: Tried and Failed to Control, Cut Down, or Stop Using an Opioid Medication (Clinical or Research Assessment Question)\tglutamate synthase complex location (Cell Component)\talpha-ketoglutarate transporter activity (dicarboxylic acid transmembrane transporter activity)\tanaphylactic; shock (Circulatory collapse and shock)\tNutritional Calcium Deficient Rickets (Disease or Syndrome)", + "output": "Tried and Failed to Control, Cut Down, or Stop Using an Opioid Medication (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Biomedical or Dental Material described as a resinous film-forming agent dissolved in a solvent or a calcium hydroxide suspension within a synthetic resin solution, which rapidly hardens into a firm mass upon administration.\nConcepts: Liner, dental (Solid Dose Form)\tIDH mutant inhibitor AG-881 (Pharmacologic Substance)\tHuntington disease-like syndrome due to C9ORF72 expansions (Huntington Disease-Like Syndrome)\tNOTCH1 Activating Gene Mutation (NOTCH1 Gene Mutation)\tStreptococcus suis (Bacterium)", + "output": "Liner, dental (Solid Dose Form)" + }, + { + "input": "Definition: Genetic Function described as interacting selectively and non-covalently with a telomeric D-loop. A telomeric D-loop is a three-stranded DNA displacement loop that forms at the site where the telomeric 3' single-stranded DNA overhang (formed of the repeat sequence TTAGGG in mammals) is tucked back inside the double-stranded component of telomeric DNA molecule, thus forming a t-loop or telomeric-loop and protecting the chromosome terminus.\nConcepts: Cingulate Bodies (Brain and Cerebral Hemispheres)\ttelomeric D-loop binding (D-loop DNA binding)\tilium (Body part)\tICD-O-3 Code (NCI Thesaurus Property)\tcytoskeletal matrix organization at active zone (Cell Function)", + "output": "telomeric D-loop binding (D-loop DNA binding)" + }, + { + "input": "Definition: something described as a finding of narrowing of the opening of a urostomy.\nConcepts: Legal policies (Governmental or Regulatory Activity)\tCD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine (Immunologic Factor)\tANTINEOPL AGENTS HORMONAL (Hormone Therapy Agent)\tUrostomy Stenosis (Injury, Poisoning and Procedural Complications, CTCAE)\tNuclear Translocation (intracellular protein transport)", + "output": "Urostomy Stenosis (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: Quantitative Concept described as the study of chance processes or the relative frequency characterizing a chance process.\nConcepts: resin composite (Dental Materials)\tprobabilities (Design, Analysis & Interpretation)\tSULFACLOMIDE (Organic Chemical)\tStreptococcus constellatus (Prevot 1924) Holdeman and Moore 1974 (Approved Lists 1980) emend. Whiley and Beighton 1991 (Streptococcus viridans group)\tBPI2-Pain Interfered General Activity (BPI Short Form Questionnaire Question)", + "output": "probabilities (Design, Analysis & Interpretation)" + }, + { + "input": "Definition: something described as the process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve.\nConcepts: Pyrimidine Synthesis Inhibition (Physiologic Function)\tPositive Group B Streptococcus Status (Qualitative Concept)\tlateral line nerve glial cell morphogenesis involved in differentiation (Cell Function)\tpeptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine (protein esterification)\tSublingual Tablet (Oromucosal AND/OR gingival dosage form)", + "output": "lateral line nerve glial cell morphogenesis involved in differentiation (Cell Function)" + }, + { + "input": "Definition: Finding described as kidney cancer in which distant metastasis cannot be assessed.\nConcepts: Monoclonal protein present (Laboratory or Test Result)\tprominosome (Extracellular Vesicles)\tLie Detection (Criminal Psychology)\tKidney Cancer pMX TNM Finding v6 (Kidney Cancer Pathologic Distant Metastasis TNM Finding v6)\tMelanin Measuring Instruments (Light meter)", + "output": "Kidney Cancer pMX TNM Finding v6 (Kidney Cancer Pathologic Distant Metastasis TNM Finding v6)" + }, + { + "input": "Definition: Finding described as a clinical finding about one or more characteristics of lip and oral cavity cancer, following the rules of the TNM AJCC v7 classification system. The assessment of the primary tumor is based on inspection and palpation of the oral cavity and neck. Additional studies may include CT, MRI, or ultrasound.\nConcepts: Always Trying to Improve Physical Appearance (Intellectual Product)\tsulcus of corpus callosum (Telencephalon)\tGlandular Kallikreins, Human (Enzyme)\tLip and Oral Cavity Cancer Clinical TNM Finding v7 (Finding)\tEzetimibe Simvastatin Combination (Dyslipidemics, Other)", + "output": "Lip and Oral Cavity Cancer Clinical TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Placental finding described as a lymphocytic inflammation of the uteroplacental vessels.\nConcepts: Chronic Uteroplacental Vasculitis (Physical shape)\tAQ0112 (AQ20 Questionnaire Question)\tSwallowings (Functions and Abnormal Functions of the Esophagus)\ttenascin (Biologically Active Substance)\tMicrobiology Susceptibility Domain (Domain)", + "output": "Chronic Uteroplacental Vasculitis (Physical shape)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+).\nConcepts: anterior part of the periventricular nucleus (parvicellular neuroendocrine cell groups)\tIf I am Sick I Would Always Contact a Doctor in This Office First (Intellectual Product)\tSodium Activated Potassium Channels (Potassium Channel)\tChemokine Ligand 24 (Chemokine Measurement)\t2'-deoxyguanosine kinase activity (Molecular Function)", + "output": "2'-deoxyguanosine kinase activity (Molecular Function)" + }, + { + "input": "Definition: Immunology described as an increased susceptibility to infections involving both the paranasal sinuses and the lungs, as manifested by a history of recurrent sinopulmonary infections.\nConcepts: 9B SEXUALITY (Personality Traits)\tSinopulmonary infections, recurrent (respiratory)\tS2 development (Organ or Tissue Function)\tNucleus corporis quadrigemini posterioris (Nucleus of tectum)\tAstler-Coller C1 Colon Carcinoma (Neoplastic Process)", + "output": "Sinopulmonary infections, recurrent (respiratory)" + }, + { + "input": "Definition: Finding described as moderate pain; limiting instrumental ADL\nConcepts: formation by symbiont of specialized structure for nutrient acquisition from host (formation of specialized structure for nutrient acquisition from other organism involved in symbiotic interaction)\tLensometers, Manual (Lensometer)\tGrade 2 Neuralgia (Finding)\tSuppressor of Fused Homolog (Transcription Regulatory Protein)\tCervical Cancer pTX TNM Finding v7 (Cervical Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Grade 2 Neuralgia (Finding)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking (faster than your usual speed) for at least 1 mile ( a little more than 1.5 km) without stopping. Please indicate why you did not do this in the past 7 days.\nConcepts: IVD Test Reagent/Kits, Serology, Parasite, Cryptosporidium Species, Antibody (Medical Device)\tAurora Kinase Inhibitor TTP607 (Pharmacologic Substance)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking Fast 1 Mile Why Not (Intellectual Product)\tAKT Gene Alteration Positive (Laboratory or Test Result)\tEtching, Dental (Therapeutic or Preventive Procedure)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking Fast 1 Mile Why Not (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+).\nConcepts: Term Birth (Prenatal AND/OR neonatal state)\tOther Problem Score 0 (Intellectual Product)\tAutosomal dominant somatic cell mutation (Autosomal dominant inheritance)\tVery Mild Bloating (Finding)\t2-hydroxyphenylpropionate hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "2-hydroxyphenylpropionate hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Clinical Trial [Publication Type] described as a clinical study that includes a comparison (control) group. The comparison group receives a placebo, another treatment, or no treatment at all.\nConcepts: Epicardial Ablation (Therapeutic or Preventive Procedure)\thistone acetyltransferase activity (Molecular Function)\tHeart Valve Prosthesis Implantation (Prosthesis Implantation)\tControlled Clinical Trial [Publication Type] (Controlled Study)\tHard to Run When in Pain (Findings-Based Question)", + "output": "Controlled Clinical Trial [Publication Type] (Controlled Study)" + }, + { + "input": "Definition: DNA repair protein described as e3 ubiquitin-protein ligase FANCL (375 aa, ~43 kDa) is encoded by the human FANCL gene. This protein is involved in the regulation of both protein ubiquitination and DNA repair.\nConcepts: PUL0228 (PUL 2.0 Functional Test Question)\tMosquito-borne viral fever, Rift valley (Mosquito-borne bunyavirus hemorrhagic fever)\tFanconi Anemia-Associated Polypeptide of 43 kDa (DNA repair protein)\ttestis cancer, seminoma and choriocarcinoma (Choriocarcinoma combined with other germ cell elements)\tFibroblast Growth Factor Receptor 2 Ser372Cys (Cell or Molecular Dysfunction)", + "output": "Fanconi Anemia-Associated Polypeptide of 43 kDa (DNA repair protein)" + }, + { + "input": "Definition: something described as an orally bioavailable imidazoquinoline targeting the phosphatidylinositol 3 kinase (PI3K) and the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. Dactolisib inhibits PI3K kinase and mTOR kinase in the PI3K/AKT/mTOR kinase signaling pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K/mTOR-overexpressing tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K.\nConcepts: DRN3 (TREX1 gene)\tTAB DISP (Biomedical or Dental Material)\t2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile (Antineoplastic Enzyme Inhibitor)\tregulation of type II hypersensitivity (regulation of hypersensitivity)\tHot water reflex epilepsy (Hereditary disorder of nervous system)", + "output": "2-methyl-2-(4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-1h-imidazo(4,5-c)quinolin-1-yl)phenyl)propanenitrile (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene is involved in DNA repair and meiotic recombination.\nConcepts: MutS, E. COLI, HOMOLOG OF, 4 (Gene or Genome)\tup regulation of fibrinolysis (negative regulation of blood coagulation)\tanastral spindle assembly (spindle assembly)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 2 Gestational Hypertension (GAIA Preeclampsia Level of Diagnostic Certainty)\tValidation Batch (product)", + "output": "MutS, E. COLI, HOMOLOG OF, 4 (Gene or Genome)" + }, + { + "input": "Definition: Growth and Development function described as includes normal and pathological, biological and age-related changes in any plant.\nConcepts: ATPase-coupled oligosaccharide transmembrane transporter activity (Molecular Function)\targinine binding (cation binding)\tpoly(glycerol phosphate) teichoic acid biosynthesis (poly(glycerol phosphate) teichoic acid metabolic process)\tplant growth development (Organism Function)\tFAC07518 (FACT-COG Version 3 Questionnaire Question)", + "output": "plant growth development (Organism Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the regulation of protein kinase A activity.\nConcepts: DUAL-SPECIFIC A KINASE-ANCHORING PROTEIN 2 (Gene or Genome)\tInstitutional Review Board Independent Ethics Committee Approved Subject Diary (Document type)\tsubarachnoid; hematoma (Cerebral injuries NEC)\tGrade 2 Vasculitis, CTCAE (Finding)\tadducted (Chemical Viewed Structurally)", + "output": "DUAL-SPECIFIC A KINASE-ANCHORING PROTEIN 2 (Gene or Genome)" + }, + { + "input": "Definition: Liver diseases described as FIBROSIS of the hepatic parenchyma due to obstruction of BILE flow (CHOLESTASIS) in the intrahepatic or extrahepatic bile ducts (BILE DUCTS, INTRAHEPATIC; BILE DUCTS, EXTRAHEPATIC). Primary biliary cholangitis involves the destruction of small intra-hepatic bile ducts and decreased bile secretion. Secondary biliary cholangitis is produced by prolonged obstruction of large intrahepatic or extrahepatic bile ducts from a variety of causes.\nConcepts: Refractory Round Cell Liposarcoma (Round Cell Liposarcoma)\tEASY BRUISABILITY (Subcutaneous hemorrhage)\tGrade 4 Hyponatremia, CTCAE (Finding)\tPHD Finger (Amino Acid Sequence)\tbiliary cirrhosis liver (Fibrosis of bile duct)", + "output": "biliary cirrhosis liver (Fibrosis of bile duct)" + }, + { + "input": "Definition: Phase I/II Trial described as select candidate vaccines or concepts suitable for Phase I and Phase II trials and conduct these trials.\nConcepts: Child-Pugh - Grade (Intellectual Product)\tSyringes, Plunger, Insulin, Protective, Fixed Needle (Medical Device)\tPhase I and II Vaccine Trials (Phase I/II Trial)\tOesophageal manometer (Medical Device)\tProduct containing zofenopril (Medicinal product categorized by structure)", + "output": "Phase I and II Vaccine Trials (Phase I/II Trial)" + }, + { + "input": "Definition: Pharmacologic Substance described as marsh buttercup.\nConcepts: teichuronic acid metabolic process (organic acid metabolic process)\tSalt-Tolerant Plants (Plant)\tHistone H2A/g (Biologically Active Substance)\tangiotensin II-mediated signaling pathway (GPCR Signaling Pathway)\tRanunculus sceleratus / marsh buttercup (Organic Chemical)", + "output": "Ranunculus sceleratus / marsh buttercup (Organic Chemical)" + }, + { + "input": "Definition: Vestibular dysfunction described as an abnormality of the vestibulo-ocular reflex (VOR). The VOR attempts to keep the image stable on the retina. Ideally passive or active head movements in one direction are compensated for by eye movements of equal magnitude.\nConcepts: UDP 4 (Pharmacologic Substance)\tTissue Specific Transplantation Antigen 1 (Ribosomal Proteins)\tAbnormal vestibulo-ocular reflex (Anatomical Abnormality)\tMebi (Quantitative Concept)\tCarbon C 14 Lenvatinib Mesylate (Indicator, Reagent, or Diagnostic Aid)", + "output": "Abnormal vestibulo-ocular reflex (Anatomical Abnormality)" + }, + { + "input": "Definition: Implantation procedure described as a technique for transplantation of stem cells, derived from embryonic gonadal ridge (embryonic germ cells), which are pluripotent and capable of self-renewal for long periods. The technique has a wide potential to cure diseases by repairing or replacing damaged cells and tissues as well as in gene therapy.\nConcepts: Male Gonadal Ridge Implantation (Implantation procedure)\tfasted state (Feeding behaviors)\tMaintaining preschool educational programme (Preschool education)\tThyroid Gland Anaplastic Carcinoma, Osteoclastic Variant (Neoplastic Process)\tNPY1R wt Allele (Gene or Genome)", + "output": "Male Gonadal Ridge Implantation (Implantation procedure)" + }, + { + "input": "Definition: TPD52 gene described as human TPD52 wild-type allele is located in the vicinity of 8q21 and is approximately 137 kb in length. This allele, which encodes tumor protein D52, may be involved in calcium-mediated signaling and mitotic progression. The wild-type allele is aberrantly expressed in several cancers.\nConcepts: specific granule membrane (Secretory granule membrane)\tFAHI Questionnaire (Clinical or Research Assessment Questionnaire)\tTPD52 wt Allele (TPD52 gene)\tQLES117 (Intellectual Product)\tLabeling Supplement (Intellectual Product)", + "output": "TPD52 wt Allele (TPD52 gene)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the myelocytes to leukocytes in a biological specimen.\nConcepts: Myelocyte to Leukocyte Ratio (Blood Cell Count Ratio Measurement)\tlamellipodium assembly involved in ameboidal cell migration (lamellipodium assembly)\tDIRAS3 wt Allele (DIRAS3 gene)\tResin Modified Glass Ionomer Liner (Biomedical or Dental Material)\tBruit, subclavian arteries or aorta (Cardio-vascular Findings: Peripheral Arteries)", + "output": "Myelocyte to Leukocyte Ratio (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: Organic Chemical described as an orally available small molecule inhibitor of Aurora kinases (AKs) A and B and other currently undisclosed kinases with potential antineoplastic and immunomodulatory activities. Upon oral administration, Aurora kinase inhibitor TT-00420 selectively binds to and inhibits AKs A and B, which may inhibit cell division in tumor cells that overexpress AKs. TT-00420 may also target other not yet disclosed kinases that play a role in tumor-associated inflammation and immune evasion. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control and are overexpressed by a wide variety of cancer cell types.\nConcepts: TT-00420 (Antineoplastic Enzyme Inhibitor)\tNeonatal bilateral clonic seizure (Neonatal electro-clinical clonic seizure)\tregulation of lateral plate mesodermal cell fate specification (Cell Function)\tCasuistry (Idea or Concept)\tmesenchymal stem cell proliferation involved in nephron morphogenesis (mesenchymal stem cell proliferation)", + "output": "TT-00420 (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Self perception, self concept pattern described as feeling of helplessness, or inability to act\nConcepts: powerlessness (Psychiatric symptoms NEC)\tJunctional Tachycardia (Finding)\tactinin-associated LIM protein, human (Amino Acid, Peptide, or Protein)\tmesencephalon (Neuroanatomy)\tCSAG3 wt Allele (Gene or Genome)", + "output": "powerlessness (Psychiatric symptoms NEC)" + }, + { + "input": "Definition: something described as used for mechanisms of heredity and the genetics of organisms, for the genetic basis of normal and pathologic states, and for the genetic aspects of endogenous chemicals. It includes biochemical and molecular influence on genetic material.\nConcepts: Adrenal Cancer pT4 TNM Finding v7 (Finding)\tStatus, Insurance (Idea or Concept)\tFACT-G Version 4 - I Have Nausea (FACT-G Version 4 Questionnaire Question)\tGE (physiological aspects)\tDisease Response and Clin Classification (Intellectual Product)", + "output": "GE (physiological aspects)" + }, + { + "input": "Definition: something described as cyto- and myeloarchitecturally defined substructures of the presubiculum. The three layers are reported in the macaque. Beginning from the surface of the brain they are: the molecular layer of the presubiculum (layer I), the principal layer of the presubiculum (layer 2) and the pyramidal layer of the presubiculum (layer 3) ( Bakst-1984 ). Six layers are distinguised in the rat ( Swanson-2004 ).\\r\\n\nConcepts: Vulvar Eccrine Porocarcinoma (Eccrine porocarcinoma)\tGAIA Neonatal Encephalopathy Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)\tMedicine or device tried or currently used to improve erection (Findings-Based Question)\tlayers of the presubiculum (Body Part, Organ, or Organ Component)\tpositive regulation of endothelial microparticle generation (regulation of endothelial microparticle formation)", + "output": "layers of the presubiculum (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Activity described as pre-event effort to coordinate and plan for response to disaster.\nConcepts: AVL01-List A Recall 5 Word 2 (ADNI-AVLT Questionnaire Question)\tprecuneate lobule (Gyrus fornicatus)\tFAC062-I Have Pain (FACT-BRM Version 4 Questionnaire Question)\tRelief Planning, Disaster (Activity)\tSplenic Manifestation of Chronic Myelogenous Leukemia (Splenic Manifestation of Leukemia)", + "output": "Relief Planning, Disaster (Activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a vaccine consisting of lymphoma-specific immunoglobulin that is not conjugated to a carrier molecule. Vaccination with unconjugated lymphoma Ig Id may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against lymphoma cells, resulting in decreased tumor growth.\nConcepts: My doctor precisely explained the advantages and disadvantages of the treatment options (Intellectual Product)\tmm/2.h (Unit of linear velocity)\tPraziquantel (isoquinoline)\tUnconjugated Lymphoma Immunoglobulin Idiotype (Anti-Idiotype Vaccine)\tABCC (Gene or Genome)", + "output": "Unconjugated Lymphoma Immunoglobulin Idiotype (Anti-Idiotype Vaccine)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Benegrastim binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.\nConcepts: Muscle hypotonicity (Finding)\tdownregulation of myeloid progenitor cell differentiation (Cell Function)\tBenegrastim (Immunologic Factor)\to-orsellinic acid metabolism (benzene-containing compound metabolic process)\tNutritional Calciopenic Rickets (Calcium Deficiency Rickets)", + "output": "Benegrastim (Immunologic Factor)" + }, + { + "input": "Definition: Veterinary proprietary drug AND/OR biological described as the maleate salt of acepromazine, a phenothiazine derivative with depressant effect on the central nervous system. Acepromazine acts as a dopamine receptor antagonist in the CNS, thereby causing sedation, muscular relaxation and a reduction in spontaneous activity. Its fast-acting neuroleptic effect with low toxicity is of particular value in veterinary medicine.\nConcepts: enteropathogenic Escherichia coli (Diarrheagenic Escherichia coli)\tUPD2-Sleep Problems (Intellectual Product)\tSCVTST (CDISC SEND Terminology)\tMouse Genome Informatics (Intellectual Product)\tMaleate, Acepromazine (Organic Chemical)", + "output": "Maleate, Acepromazine (Organic Chemical)" + }, + { + "input": "Definition: something described as colorectal cancer with metastasis to one or more distant sites or organs or peritoneal metastasis is identified.\nConcepts: AVRGJW (Finding)\tCellular Differentiation (Histology Procedure)\tTRANSFORMING GROWTH FACTOR BETA-1 (Amino Acid, Peptide, or Protein)\tNecrotizing Enterocolitis Totalis (Necrotizing enterocolitis in fetus OR newborn)\tColorectal Carcinoma pM1 TNM Finding v8 (Finding)", + "output": "Colorectal Carcinoma pM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Water-soluble vitamin described as a nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Pantothenic acid helps some enzymes use foods and make many substances used in the body and protects cells against damage from peroxides. It is found in almost all plant and animal foods. Pantothenic acid is water-soluble (can dissolve in water) and must be taken in every day.\nConcepts: Transmission, Perinatal Infection (Pathologic Function)\tsocial contact (PSYCHOSOCIAL DOMAIN)\tComprehensive 60 minute new (Phone conversations with or without ICD diagnosis)\tvitamin b5 (vitamin B complex)\tFemtomole (SI unit of amount of substance)", + "output": "vitamin b5 (vitamin B complex)" + }, + { + "input": "Definition: something described as an enzyme that catalyzes the formation of UDPglucose from UTP plus glucose 1-phosphate. EC 2.7.7.9.\nConcepts: FACT/GOG-Ntx Subscale (Clinical or Research Assessment Questionnaire)\tHda-beta clamp complex (Cell Component)\tMirror Neurons (Neurons)\ttRNA modification guide activity (tRNA binding)\tUridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase (Amino Acid, Peptide, or Protein)", + "output": "Uridine triphosphate (UTP)-glucose-1-phosphate uridylyltransferase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a coded value specifying a further description of the type of item being counted.\nConcepts: eating disrdr cnslng ndvdl e (mental health counseling)\tStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum (Exfoliative dermatitis)\tcountTypeDetailCode (Code)\tChart abstracting (Chart related administrative procedure)\tDecreased mannosylation of N-linked protein glycosylation (Abnormal mannosylation of N-linked protein glycosylation)", + "output": "countTypeDetailCode (Code)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine.\nConcepts: Nanoparticle Application (Research Techniques)\th.ng/mL/(mg/kg/d) (Measurement Unit Description)\tTRT (Intellectual Product)\tPartial Colectomy (Therapeutic or Preventive Procedure)\t2-keto-4-methylthiobutyrate aminotransferase activity (aminotransferase activity)", + "output": "2-keto-4-methylthiobutyrate aminotransferase activity (aminotransferase activity)" + }, + { + "input": "Definition: Medical Device described as an X-ray radiation therapy system is a device intended to produce and control X-rays used for radiation therapy. This generic type of device may include signal analysis and display equipment, patient and equipment supports, treatment planning computer programs, component parts, and accessories.\nConcepts: Stage I Adult Non-Hodgkin's Lymphoma (Adult Non-Hodgkin's Lymphoma Stage)\tpeptidyl-phenylalanine modification (Molecular Function)\tSpondylosis NOS (Spondylosis and allied disorders)\tGENERATOR, DERMATOLOGICAL (GRENZ RAY), THERAPEUTIC X-RAY (Medical Device)\tAnti-GD2L Antibody (Amino Acid, Peptide, or Protein)", + "output": "GENERATOR, DERMATOLOGICAL (GRENZ RAY), THERAPEUTIC X-RAY (Medical Device)" + }, + { + "input": "Definition: something described as clinical and/or laboratory evidence of early reemergence of a disorder after a period of remission.\nConcepts: TRAF Motif (Protein Binding Motif)\tDRUG WITHDRAWN (Therapeutic or Preventive Procedure)\tEarly Recurrence (Finding)\tsalicylic acid metabolic process (monocarboxylic acid metabolic process)\tUndifferentiated carcinoma of corpus uteri (Neoplastic Process)", + "output": "Early Recurrence (Finding)" + }, + { + "input": "Definition: molecular shape described as lack of symmetry in the special arrangements of the atoms and radicals within the molecule or crystal.\nConcepts: Bailiwick of Guernsey (Geographic Area)\tRNA polymerase activity (catalytic activity, acting on RNA)\tmolecular asymmetry (Spatial Concept)\tAkt/ERK inhibitor ONC201 (Pharmacologic Substance)\tInhalation Powder, Tablet Dosage Form (Inhalation Powder)", + "output": "molecular asymmetry (Spatial Concept)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as the use of HIGH-ENERGY SHOCK WAVES, in the frequency range of 20-60 kHz, to cut through or remove tissue. The tissue fragmentation by ultrasonic surgical instruments is caused by mechanical effects not heat as with HIGH-INTENSITY FOCUSED ULTRASOUND ABLATION.\nConcepts: Procedures, Ultrasonic Surgical (Operative Surgical Procedures)\tSurvivorship Care Plan (Document type)\t5'-methylthioadenosine deaminase activity (deaminase activity)\tDUX4 Gene (Gene or Genome)\tsubstance P catabolic process (neuropeptide catabolic process)", + "output": "Procedures, Ultrasonic Surgical (Operative Surgical Procedures)" + }, + { + "input": "Definition: something described as an immunoglobulins A, G, M, D, and E immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the immunoglobulins A, G, M, D, an E (serum antibodies) in serum. Measurement of these immunoglobulins aids in the diagnosis of abnormal protein metabolism and the body's lack of ability to resist infectious agents.\nConcepts: primary lysosome (Lysosomes)\tConflict Resolutions (collaboration, competition, conflict, and outcome)\tNPI1-Hallucinations Frequency (NPI Questionnaire Question)\tMitogen-Activated Protein Kinase 15 (Mitogen-Activated Protein Kinases)\tIGG, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "IGG, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Squamous cell carcinoma described as a malignant epithelial neoplasm involving all the layers of the squamous epithelium, but it is not certain if it is confined to the squamous epithelium or it has invaded the basement membrane and the underlying stroma.\nConcepts: Performed Diagnosis (Performed Clinical Study Activity)\tRisk Control: Hypotension (Finding)\tEpidermoid carcinoma in situ + questionable stromal invasion (Papillary and Squamous Cell Neoplasms)\tFabricius Bursa (Experimental Organism Anatomical Concept)\tDopamine receptor antagonist (Agent Affecting Nervous System)", + "output": "Epidermoid carcinoma in situ + questionable stromal invasion (Papillary and Squamous Cell Neoplasms)" + }, + { + "input": "Definition: something described as judkins left 4.5\nConcepts: Melanoma of the Conjunctiva cT3a TNM Finding v7 (Melanoma of the Conjunctiva cT3 TNM Finding v7)\tIVD Test Reagent/Kits, Immunoassay, Standard, Bone Metabolism Hormone (Medical Device)\tdexmedetomidine HCl (Adrenergic alpha-2 Receptor Agonists)\tJL 4.5 (Medical Device)\tAccount Administrator (Professional or Occupational Group)", + "output": "JL 4.5 (Medical Device)" + }, + { + "input": "Definition: something described as human CCL14 wild-type allele is located in the vicinity of 17q11.2 and is approximately 3 kb in length. This allele, which encodes C-C motif chemokine 14 protein, is involved in the regulation of intracellular calcium concentration and enzyme release in monocytes. The allele also plays a role in CD34 myeloid progenitor cell proliferation.\nConcepts: CRANIAL (Topographical modifier)\tSCYL2 (Gene or Genome)\tUDP glucuronosyltransferase family 2 member B17 (Gene or Genome)\trhinencephalon of Crosby (Body Part, Organ, or Organ Component)\tSolute Carrier Family 43 (L-Type Amino Acid Transporter), Member 2 Gene (SLC43A2 gene)", + "output": "SCYL2 (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the PODCI Adolescent Self-Reported Version questionnaire.\nConcepts: Maternal-Fetal Examination (Diagnostic Procedure)\tEBN1IGAB (Laboratory Procedure)\tcarbon C 14 pevonedistat (Pharmacologic Substance)\tbiological (Qualitative Concept)\tPODCI Adolescent Self-Reported Version Questionnaire Question (Clinical or Research Assessment Question)", + "output": "PODCI Adolescent Self-Reported Version Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: VFQ25-Interviewer Administered Format Questionnaire Question described as visual Functioning Questionnaire 25-Interviewer Administered Format Version 2000 (VFQ25-Interviewer Administered Format) Role Limitations: Are you limited in the kinds of things you can do because of your vision?\nConcepts: Uracil nitrogen mustard (Nitrogen Mustard Antineoplastic Compounds)\tTablet, extended release (Extended Release Dosage Form)\tActinomadura pelletieri (Actinomadura)\tdownregulation of catecholamine uptake during transmission of nerve impulse (regulation of catecholamine uptake involved in synaptic transmission)\tVFQ25-Interviewer Administered Format - Limited in Kinds of Things Can Do (VFQ25-Interviewer Administered Format Questionnaire Question)", + "output": "VFQ25-Interviewer Administered Format - Limited in Kinds of Things Can Do (VFQ25-Interviewer Administered Format Questionnaire Question)" + }, + { + "input": "Definition: Gastrointestinal signs and symptoms NEC described as gastrointestinal symptoms resulting from an absent or nonfunctioning pylorus.\nConcepts: Eosinophilic Granulomatous Vasculitides (Hypersensitivity)\tBody (Postnatal anatomical structure)\tPost-cibal syndrome (Syndrome)\tVAT1 (SLC18A1 gene)\tBOLIVIA (South America)", + "output": "Post-cibal syndrome (Syndrome)" + }, + { + "input": "Definition: something described as pathologic TNM staging performed with access to postneoadjuvant therapy information only.\nConcepts: PCMETHOD (Functional Concept)\tPostneoadjuvant Therapy Pathologic TNM Finding (Cancer TNM Finding Category)\tGynecomastia (Reproductive System and Breast Disorders, CTCAE)\tregulation of collateral sprouting of intact axon in response to injury (regulation of axon regeneration)\tIRS4 gene (Adaptor Signaling Protein Gene)", + "output": "Postneoadjuvant Therapy Pathologic TNM Finding (Cancer TNM Finding Category)" + }, + { + "input": "Definition: something described as zinc finger protein ZFPM2 (1151 aa, ~128 kDa) is encoded by the human ZFPM2 gene. This protein plays a role in DNA binding, transcriptional regulation and cardiac development.\nConcepts: Zinc Finger Protein 89B (Amino Acid, Peptide, or Protein)\tCixutumumab (Immunologic Factor)\tThyroiditides, Lymphocytic (Thyroid Diseases)\tFAC084-Part I: Walk Up 20 Stairs (Intellectual Product)\toptic disc swelling (Abnormality of the optic disc)", + "output": "Zinc Finger Protein 89B (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Blood and lymphatic system disorders described as neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas).\nConcepts: Using general skills and strategies of the reading process (Reading)\tpositive regulation of angiotensin-activated signaling pathway (regulation of angiotensin-activated signaling pathway)\tHematopoietic and Lymphoid System Neoplasm (Blood and lymphatic system disorders)\tHis Bund (junct ectopic) tachy (Neonatal cardiovascular disorders)\tdown regulation of intrinsic apoptotic signaling pathway in response to hypoxia (negative regulation of cellular response to hypoxia)", + "output": "Hematopoietic and Lymphoid System Neoplasm (Blood and lymphatic system disorders)" + }, + { + "input": "Definition: Neoplastic Process described as stage IIIB small cell lung carcinoma that has not spread to the pleural fluid.\nConcepts: pT2 Lung Cancer v6 (Lung Cancer Pathologic Primary Tumor TNM Finding v6)\tCaMKIV (protein serine/threonine kinase activity)\tHybrid Selected Genomic Library (Nucleic Acid, Nucleoside, or Nucleotide)\tStage IIIB Small Cell Carcinoma of the Lung without Pleural Effusion (Neoplastic Process)\tSTAINING (Miscellaneous)", + "output": "Stage IIIB Small Cell Carcinoma of the Lung without Pleural Effusion (Neoplastic Process)" + }, + { + "input": "Definition: something described as a homeodomain protein and transcription regulator that functions in BLASTOCYST INNER CELL MASS and EMBRYONIC STEM CELL proliferation and CELL SELF RENEWAL. It confers pluripotency on embryonic stem cells and prevents their differentiation towards extraembryonic ENDODERM and trophectoderm (TROPHOBLAST) CELL LINEAGES.\nConcepts: Minute Times Femtogram Per Milliliter Per Gram (Measurement Unit Description)\tPrimary Debulking Surgery (Therapeutic or Preventive Procedure)\tMicrobial Physiology (Occupation or Discipline)\tTSQM Version 1.4 - How Bothersome Are Side Effects (TSQM Version 1.4 Questionnaire Question)\tNanog Protein (Amino Acid, Peptide, or Protein)", + "output": "Nanog Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as a implantable cardiac pacemaker with an additional third lead placed in the left ventricle that is designed to keep the contractions of the ventricles synchronized with each other.\nConcepts: Cardiac Myosins (Amino Acid, Peptide, or Protein)\tBiventricular Pacemakers (Medical Device)\tI309 (Immunologic Factor)\tCCQ01TC (CDISC Questionnaire Terminology)\tplant seed peroxidase activity (oxidoreductase activity, acting on peroxide as acceptor)", + "output": "Biventricular Pacemakers (Medical Device)" + }, + { + "input": "Definition: LOXL2 gene described as human LOXL2 wild-type allele is located in the vicinity of 8p21.3 and is approximately 107 kb in length. This allele, which encodes lysyl oxidase homolog 2 protein, plays a role in the mediation of crosslink formation in connective tissue proteins.\nConcepts: Endocardium of inflow part of left atrium (Body Part, Organ, or Organ Component)\tEffervescent oral granules (Granules dose form)\tCystoliths (Urinary tract lithiasis)\tENDOMETRIUM CANCER (Adult Solid Neoplasm)\tLOR2 (Gene or Genome)", + "output": "LOR2 (Gene or Genome)" + }, + { + "input": "Definition: Abnormality of the phalanges of the toes described as increased width of phalanx of one or more toes.\nConcepts: N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride (Sympatholytics)\tWide toe bones (Broad phalanx)\tFACIT-Dyspnea Scale 33 Item Bank Version - Limit: Walking Fast 1 Mile (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tslfcare trn grp ea.15min (Rehabilitative treatments and/or training)\tup regulation of TRAIL receptor 2 biosynthetic process (regulation of TRAIL receptor 2 biosynthetic process)", + "output": "Wide toe bones (Broad phalanx)" + }, + { + "input": "Definition: something described as a class of clinical study that combines elements characteristic of traditional Phase I and Phase II trials. See also Phase I, Phase II.\nConcepts: calcifediol anhydrous (Vitamin D Analog)\t3q22 (Chromosome band)\tSIQ0123 (Intellectual Product)\torganosulphide cycle (Sulfur Metabolism Pathway)\t1-2 (Clinical Study by Phase)", + "output": "1-2 (Clinical Study by Phase)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as brucella spp. serological reagents are devices that consist of antigens and antisera used for serological identification of Brucella spp. from cultured isolates derived from clinical specimens or to identify antibodies to Brucella spp. in serum. Additionally, some of these reagents consist of antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify Brucella spp. directly from clinical specimens or cultured isolates derived from clinical specimens. The identification aids in the diagnosis of brucellosis (e.g., undulant fever, Malta fever) caused by bacteria belonging to the genus Brucella and provides epidemiological information on diseases caused by these microorganisms.\nConcepts: phosphatase activator activity (enzyme activator activity)\tTongue-like lumbar vertebral deformities (Anterior beaking of lumbar vertebrae)\t10^8{TCID50} (Quantitative Concept)\tANTISERUM, POSITIVE AND NEGATIVE FEBRILE ANTIGEN CONTROL SERUM (Indicator, Reagent, or Diagnostic Aid)\t25-Hydroxyvitamin D Less than 32 Nanograms/Milliliter (Laboratory test finding)", + "output": "ANTISERUM, POSITIVE AND NEGATIVE FEBRILE ANTIGEN CONTROL SERUM (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Powder dose form described as solid preparation consisting of one or more powders, intended to be dissolved in the specified liquid to obtain a nebulizer solution.\nConcepts: Preanesthetic medication (Sedation procedure)\tPowder for nebulizer solution (Powder for Solution Dosage Form)\tphonologies (grammar)\tdistended umbilical veins (Vascular anomaly of umbilical cord)\tGlands, Pituitary (Hypothalamic structure)", + "output": "Powder for nebulizer solution (Powder for Solution Dosage Form)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable inhibitor of colony stimulating factor 1 receptor (CSF-1R; CSF1R), with potential antineoplastic activity. CSF1R inhibitor BLZ945 selectively binds to CSF1R expressed on tumor-associated macrophages (TAMs), blocks the activity of CSF1R, and inhibits CSF1R-mediated signal transduction pathways. This inhibits the activity and proliferation of TAMs, and reprograms the immunosuppressive nature of existing TAMs. Altogether, this reduces TAM-mediated immune suppression in the tumor microenvironment, re-activates the immune system, and improves anti-tumor cell responses mediated by T-cells. CSF1R, also known as macrophage colony-stimulating factor receptor (M-CSFR) and CD115 (cluster of differentiation 115), is a cell-surface receptor for its ligand, colony stimulating factor 1 (CSF1); this receptor is overexpressed by TAMs in the tumor microenvironment, and plays a major role in both immune suppression and the induction of tumor cell proliferation. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C129653\" active clinical trials using this agent.\nConcepts: ketosteroid monooxygenase activity (Molecular Function)\tLow Grade Accessory Sinus Sarcoma (sarcoma of accessory sinus)\tF-box domain binding (protein domain specific binding)\tIVD Test Reagent/Kits, Clinical Chemistry, Standard, Electrolyte Test (IVD Test Reagent/Kits, Clinical Chemistry, Standard)\tBLZ-945 (Organic Chemical)", + "output": "BLZ-945 (Organic Chemical)" + }, + { + "input": "Definition: Cell Component described as any collagen timer that is part of a basement membrane.\nConcepts: nuclear envelope reassembly (nuclear envelope organization)\tMotions (Action)\tbiotin import into cell (Import into cell)\tbasement membrane collagen trimer (collagen location)\tMeasurement, Test or Examination Detail (Details)", + "output": "basement membrane collagen trimer (collagen location)" + }, + { + "input": "Definition: DLQI Questionnaire Question described as dermatology Life Quality Index (DLQI) Over the last week, has your skin prevented you from working or studying?\nConcepts: DLQI107 (DLQI Questionnaire Question)\tSite visit review of new housing development (Review of new housing development)\tburst respiratory (Cell Function)\tControlled Oral Word Association (Intellectual Product)\tADMLX (Extracellular Matrix Protein Gene)", + "output": "DLQI107 (DLQI Questionnaire Question)" + }, + { + "input": "Definition: something described as this gene is involved in growth factor signaling.\nConcepts: Sponges, Antiseptic (Sponges)\tFibroblast Growth Factor 19 Gene (Gene or Genome)\tGAD02-Being Restless Hard to Sit Still (Intellectual Product)\tHemodynamic edema, effusions and fluid overload (Classification)\tDental Crowns, Partial (Prostheses, Dental, Fixed, Crown)", + "output": "Fibroblast Growth Factor 19 Gene (Gene or Genome)" + }, + { + "input": "Definition: Melanoma of the Uvea Pathologic TNM Finding v7 described as a pathologic finding about one or more characteristics of melanoma of the uvea, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for melanoma of the uvea.\nConcepts: Melanoma of the Uvea Pathologic Distant Metastasis TNM Finding v7 (Finding)\tbulbus arteriosus formation (Organ or Tissue Function)\toptometrists (Professional or Occupational Group)\tdimethyl sulphoxide reductase activity (oxidoreductase activity, acting on a sulfur group of donors)\tAKN -028 (Pharmacologic Substance)", + "output": "Melanoma of the Uvea Pathologic Distant Metastasis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Personality Development described as chaotic concept of self wherein one's role in life appears to be an insoluble dilemma often expressed by isolation, withdrawal, rebellion and extremism.\nConcepts: Identity Crisis (Crisis)\tCALCULATOR/DATA PROCESSING MODULE, FOR CLINICAL USE (Medical Device)\tHTKL (Gene or Genome)\tMFIS Questionnaire Question (Clinical or Research Assessment Question)\tAbnormal intestine morphology (Morphological abnormality of the gastrointestinal tract)", + "output": "Identity Crisis (Crisis)" + }, + { + "input": "Definition: Duffy blood group result described as presence of the Duffy Fyb antigen.\nConcepts: proline transmembrane transport (amino acid transmembrane transport)\tDuffy Fyb positivity (Finding)\tNational Center for Complementary and Integrative Health (Component of the National Institutes of Health)\tlymph gland plasmatocyte differentiation (larval lymph gland hemocyte differentiation)\tTetra-Amelia (Congenital absence of lower limb)", + "output": "Duffy Fyb positivity (Finding)" + }, + { + "input": "Definition: Metabolism described as the chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems.\nConcepts: GMPS/MLL FUSION GENE (Gene or Genome)\tplasma lipoprotein particle clearance (multicellular organismal process)\tself-medication (Thesaurus of Psychological Index Terms)\tmetabolism vitamin (Metabolism)\tGonadotropin-Independent Precocious Puberty (Disorder of endocrine gonad)", + "output": "metabolism vitamin (Metabolism)" + }, + { + "input": "Definition: Finding described as tachyarrhythmia is any disturbance of the heart rhythm in which the heart rate is abnormally increased.\nConcepts: LOBELIA SIPHILITICA ROOT OIL (Plant Oils)\tInteratrial septum (Heart)\tChief Complaint Continuously Present (Chief complaint)\ttachyarrhythmias (Conduction disorder of the heart)\tRhabdomyosarcoma of Prostate (Neoplastic Process)", + "output": "tachyarrhythmias (Conduction disorder of the heart)" + }, + { + "input": "Definition: something described as a lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma.\nConcepts: Mediastinal Malignant Lymphoma (Malignant tumor of mediastinum)\tReceptors, Notch (Receptors, Cell Surface)\tAbility to Participate in Sexual Activities (Clinical or Research Assessment Question)\tblood complications transfusions (Transfusion Reaction)\tSeparate origin of the left anterior descending and left circumflex artery (Anatomical Abnormality)", + "output": "Mediastinal Malignant Lymphoma (Malignant tumor of mediastinum)" + }, + { + "input": "Definition: Muscle described as the thin skeletal muscle within the subcutaneous tissue.\nConcepts: PETA3 (Gene or Genome)\tCutaneous Trunci (Body Part, Organ, or Organ Component)\tTectum (Body Part, Organ, or Organ Component)\tCichorium intybus homeopathic preparation (Homeopathic remedies letter C)\t338-345 BUNYAVIRUS GROUP (Peribunyaviridae)", + "output": "Cutaneous Trunci (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as element of the rare earth family of metals, atomic symbol Yb, atomic number 70; used in lasers and as a portable x-ray source.\nConcepts: No Fatigue (Positive Diagnosis And Outcome)\tReason Code (Intellectual Product)\tYtterbium (Elements)\tBevacizumab-IRDye 800CW (Immunoconjugates)\tSURVEYS DIS FREQUENCY (one-time and longitudinal study)", + "output": "Ytterbium (Elements)" + }, + { + "input": "Definition: positive regulation of protein localization to membrane described as any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.\nConcepts: Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 (Cutaneous Squamous Cell Carcinoma of the Head and Neck by AJCC v8 Stage)\tRecorders, Audio, Compact Disk (Manufactured Object)\tGastrostomy tube feeding in infancy (Finding)\tpositive regulation of protein targeting to membrane (regulation of protein targeting to membrane)\tANTIGENS CD 002 (Antigens, Differentiation, T-Lymphocyte)", + "output": "positive regulation of protein targeting to membrane (regulation of protein targeting to membrane)" + }, + { + "input": "Definition: ARNT2 gene described as human ARNT2 wild-type allele is located in the vicinity of 15q24 and is approximately 194 kb in length. This allele, which encodes aryl hydrocarbon receptor nuclear translocator 2 protein, plays a role in the regulation of the transcriptional responses to both xenobiotic chemicals and environmental stimuli.\nConcepts: KIAA0307 (Gene or Genome)\tT4 Stage Finding (Tumor stage finding)\tPregnant Uterus (Body Part, Organ, or Organ Component)\tevan's syndrome (Non-Neoplastic Hematologic and Lymphocytic Disorder)\tActivity Identifier (Identifier)", + "output": "KIAA0307 (Gene or Genome)" + }, + { + "input": "Definition: Biologic Function described as any process that modulates the frequency, rate, or extent of antimicrobial peptide production.\nConcepts: multicellular organism reproduction (Organism Function)\tregulation of antimicrobial peptide production (Biologic Function)\tChemoprevention of Cancer (Cancer Prevention)\tPuff, Chromosome (Cell Component)\tsuccinyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "regulation of antimicrobial peptide production (Biologic Function)" + }, + { + "input": "Definition: Language described as a language of the Zuni people, indigenous to western New Mexico and eastern Arizona in the United States.\nConcepts: PIF-1 peptide (Pharmacologic Substance)\tRetromammary fascia (Zone of superficial fascia of breast)\tZUN (AmericanIndianAlaskaNativeLanguages)\tDigital Data Duplicators (Electromechanical Devices)\t11p11.2 (Chromosome band)", + "output": "ZUN (AmericanIndianAlaskaNativeLanguages)" + }, + { + "input": "Definition: Organism Attribute described as the reactivation of a defective virus either by recombination or by complementation of the defective functions.\nConcepts: voltage-gated sodium channel activity (Molecular Function)\tAccepting novelty (Individual Behavior)\t3-(5-Dimethylcarbamoylpyrrolidin-3-ylthio)-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid (Antibiotic)\tviral rescue (Organism Attribute)\tSegmenta medullae spinalis (Body Part, Organ, or Organ Component)", + "output": "viral rescue (Organism Attribute)" + }, + { + "input": "Definition: something described as submission of original promotional materials. Includes 2253 submissions, requests for advisory on launch materials, requests for advisory on non-launch materials, pre-submission of promotional materials for accelerated approval products, and materials submitted pursuant to 503B.\nConcepts: pentalenolactone degradation (antibiotic catabolic process)\tVeterans Health Services (Health Services)\tMerkel Cell Tumor (Intellectual Product)\tepidermis morphogenesis (morphogenesis of an epithelium)\tNew Regulatory Submission (Regulatory Submission)", + "output": "New Regulatory Submission (Regulatory Submission)" + }, + { + "input": "Definition: molybdopterin cofactor catabolic process described as the chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.\nConcepts: SCN5A protein, human (Ion Channel Protein)\tVenoms, Viper (Snake Venoms)\tSynovial Sarcoma, X Breakpoint 4 wt Allele (Gene or Genome)\tMo-molybdopterin cofactor catabolic process (molybdopterin cofactor catabolic process)\tRCAF complex (Cell Component)", + "output": "Mo-molybdopterin cofactor catabolic process (molybdopterin cofactor catabolic process)" + }, + { + "input": "Definition: Cell described as multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82688\" active clinical trials using this agent.\nConcepts: Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide 1 (Amino Acid, Peptide, or Protein)\tTea1 cell-end complex location (microtubule associated complex)\tPARACENTESIS (Aspiration-action)\tMethylbutyrase (Carboxylic Ester Hydrolases)\tumbilical cord blood-derived MSCs (Non-Tumor Cell Derivative Vaccine)", + "output": "umbilical cord blood-derived MSCs (Non-Tumor Cell Derivative Vaccine)" + }, + { + "input": "Definition: Ion Channel described as voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions.\nConcepts: DKFZP434F076 (Transport Protein Gene)\tSmall Intestine Cancer pM1 TNM Finding v7 (Small Intestine Cancer Pathologic Distant Metastasis TNM Finding v7)\tEEG: localised low amplitude activity (Finding)\tCalelectrin 67 kDa (Amino Acid, Peptide, or Protein)\tCalcium Ion Channel (Ion Channel)", + "output": "Calcium Ion Channel (Ion Channel)" + }, + { + "input": "Definition: Squamous cell carcinoma described as a rare carcinoma of the stomach resembling squamous cell carcinomas arising elsewhere in the body.\nConcepts: negative regulation of mRNA cis splicing, via spliceosome (negative regulation of mRNA splicing, via spliceosome)\tMENTAL RETARDATION, X-LINKED, SYNDROMIC, BROOKS-WISNIEWSKI-BROWN TYPE (Genetic Diseases, X-Linked)\tGastric Squamous Cell Carcinoma (Carcinoma)\tCELLDMAX (Cell Density)\tcholine inhibitor (Pharmacologic Substance)", + "output": "Gastric Squamous Cell Carcinoma (Carcinoma)" + }, + { + "input": "Definition: Brassicaceae described as a plant genus of the family BRASSICACEAE. Some members contain CARDIAC GLYCOSIDES.\nConcepts: Breast Implants, Nipple (Medical Device)\to-orsellinic acid metabolic process (Secondary Metabolism)\tarabinose:hydrogen symporter activity (arabinose transmembrane transporter activity)\tErysimums (Brassicaceae)\tpapillary serous adenocarcinoma (Neoplastic Process)", + "output": "Erysimums (Brassicaceae)" + }, + { + "input": "Definition: something described as the processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.\nConcepts: Pattern Specification, Body (Morphogenesis)\tAdverseEvent.hospitalizationRequiredIndicator (Hospitalization Required Indicator)\tGrade 2 Wound Complication, CTCAE (Wound Complication, CTCAE)\tmethane biosynthetic process from carbon monoxide (Molecular Function)\tAbnormal conjugate eye movement (Finding)", + "output": "Pattern Specification, Body (Morphogenesis)" + }, + { + "input": "Definition: something described as a secreted HEPARIN-binding glycoprotein of approximately 35 kD, encoded by the FSTL1 or FRP gene. Expression of follistatin-related protein 1 is associated with growth inhibition and CELL DIFFERENTIATION.\nConcepts: Anthracycline (Organic Chemical)\tFollistatin Like Protein 1 (Amino Acid, Peptide, or Protein)\tNAD(H) analog (nucleotide analog)\tpyloric antrum smooth muscle contraction (stomach pylorus smooth muscle contraction)\tNP 005219.2:p.His773 Val774insGlyAsnProHis (EGFR Protein Variant)", + "output": "Follistatin Like Protein 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: transmembrane receptor protein tyrosine kinase signaling pathway described as the series of molecular signals generated as a consequence of growth hormone receptor binding to its physiological ligand.\nConcepts: drunks (Alcoholic Intoxication, Chronic)\tBatroxobine (Other systemic hemostatics in ATC)\tIncreased interpupillary distance (Musculoskeletal and connective tissue disorders of face, neck and jaw congenital)\tLugano Classification Hodgkin Lymphoma by AJCC v8 Stage (Neoplastic Process)\tGH receptor signaling pathway (Molecular Function)", + "output": "GH receptor signaling pathway (Molecular Function)" + }, + { + "input": "Definition: specification of segmental identity, head described as the specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized.\nConcepts: AUMC Dosing to Last Concentration Normalized by Dose (Area Under First Moment Curve)\tMalignant Skull Base Neoplasm (Malignant Intracranial Neoplasm)\tCyclic Citrullinated Peptide IgG Ab (Immunoglobulin measurement)\tspecification of segmental identity, maxillary segment (specification of segmental identity, head)\tKluyveromyce (Saccharomycetaceae)", + "output": "specification of segmental identity, maxillary segment (specification of segmental identity, head)" + }, + { + "input": "Definition: something described as the directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form.\nConcepts: regulation of response to drug (regulation of response to stimulus)\tflavin adenine dinucleotide transport (coenzyme transport)\tSFMTYP (Qualitative Concept)\tsterol catabolism (Molecular Function)\tADENINE NUCLEOTIDE QUANTITATION (Indicator, Reagent, or Diagnostic Aid)", + "output": "flavin adenine dinucleotide transport (coenzyme transport)" + }, + { + "input": "Definition: Diaphyses described as the long, curved portion of the rib, which contains the intercostal vein, artery, and nerve in a groove found in the inferior margin.\nConcepts: EMO1-Number Stimuli Portraying Sadness (ERT Functional Test Question)\tPSEUDOMONAS MOSSELII (Bacterium)\tDKCB4 Gene Mutation (Gene Mutant)\tSerotonin 2A Receptor (Amino Acid, Peptide, or Protein)\tCorpus costae (Body Part, Organ, or Organ Component)", + "output": "Corpus costae (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as trauma to the lower extremity, which is confined to the area between the hip and ankle joints.\nConcepts: Angiopoietin 1 Gene (Gene or Genome)\tEthnic Violence (Violence)\tLeg Injuries (Injury or Poisoning)\tLipoylation (Natural Phenomenon or Process)\tDisease, Deficiency (Disease or Syndrome)", + "output": "Leg Injuries (Injury or Poisoning)" + }, + { + "input": "Definition: AIDS-Related Kaposi Sarcoma T1 (Poor Risk): Widespread Tumor described as AIDS-related Kaposi sarcoma involving organs other than the lungs or gastrointestinal tract. It includes liver, bladder, reproductive tract, heart, and endocrine organs.\nConcepts: Stage IIB Rectal Cancer (Neoplastic Process)\tTherapeutic Glucocorticoid (Anti-Inflammatory Agents)\tAIDS-Related Kaposi Sarcoma T1 (Poor Risk): Other Non-Nodal Viscera Involvement (AIDS-Related Kaposi Sarcoma T1 (Poor Risk): Widespread Tumor)\tProcedure Kit/Trays, Implant Delivery, Bladder Support, Suprapubic (Procedure Kit/Trays, Implant Delivery, Bladder Support)\tmonocyte chemotactic protein-1 production (chemokine production)", + "output": "AIDS-Related Kaposi Sarcoma T1 (Poor Risk): Other Non-Nodal Viscera Involvement (AIDS-Related Kaposi Sarcoma T1 (Poor Risk): Widespread Tumor)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar.\nConcepts: FAC063-Get Emotional Support From Family (FACT-Taxane Version 4 Questionnaire Question)\tpyrimidine ribonucleoside diphosphate synthesis (pyrimidine nucleoside diphosphate biosynthetic process)\tOMPP (Primary immune deficiency disorder)\tInterresponse Time (Temporal Concept)\tGOT1 (Amino Acid, Peptide, or Protein)", + "output": "pyrimidine ribonucleoside diphosphate synthesis (pyrimidine nucleoside diphosphate biosynthetic process)" + }, + { + "input": "Definition: Date/Time described as an expression of both a date and time when a particular study activity assigned to be performed.\nConcepts: Anaplastic Small Cell Carcinoma of the Salivary Gland (Malignant neoplasm of salivary gland)\tExcessive insulin response to glucagon test (Finding)\tScheduled Study Activity Date and Time (Temporal Concept)\tSource Document (Intellectual Product)\tAutoimmune (Functional Concept)", + "output": "Scheduled Study Activity Date and Time (Temporal Concept)" + }, + { + "input": "Definition: something described as a clinical trial or treatment setting in which the therapy of interest is used to treat locally advanced disease.\nConcepts: Locally Advanced Disease Clinical Trial Setting (Clinical Trial Setting)\tarm board (Table - furniture)\tIVD Test Reagent/Kits, Immunoassay, Thyroid Hormone, Thyroxin, Free (Medical Device)\tolfactory bulb interneuron differentiation (forebrain neuron differentiation)\tSoftware, Laboratory Analysis, Hematology, Coagulation (Software, Laboratory Analysis, Hematology)", + "output": "Locally Advanced Disease Clinical Trial Setting (Clinical Trial Setting)" + }, + { + "input": "Definition: something described as a mental disorder caused by intrinsic disease which is characterized by persistent or recurrent irrational beliefs. Consciousness and memory are not affected. It may be broadly classified as a psychotic disorder due to a general medical condition.\nConcepts: Spastic paraplegia with Paget disease of bone syndrome (Osteitis Deformans)\torganic; delusional (Mental or Behavioral Dysfunction)\tHemopoietic Cell Kinase wt Allele (Gene or Genome)\tStage IIC Colon Cancer (Stage II Colon Cancer AJCC v7)\tUntreated Low Grade Astrocytic Tumor (Finding)", + "output": "organic; delusional (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Organic Chemical described as a short chain fatty acid (SCFA) with potential herpes simplex virus thymidine kinase gene (HSV-TK)-inducing activity. Upon administration, short chain fatty acid HQK-1004 may induce the expression of thymidine kinase (TK) by a silenced HSV-TK, which may activate a co-administered antiviral prodrug such as ganciclovir, resulting in the destruction of virally-infected cancer cells.\nConcepts: HQK-1004 (Organic Chemical)\tGUANYLIN (Gene or Genome)\tASSEMBLY, THIGH/KNEE/SHANK/ANKLE/FOOT, EXTERNAL (Medical Device)\ttype schizophrenia (Psychiatric problem)\tNucletron Oncentra (Computer Systems)", + "output": "HQK-1004 (Organic Chemical)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic dialkyl phosphate compound and organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a volatile yellow brown liquid with a mild ester odor, and exposure occurs by inhalation, ingestion, or contact.\nConcepts: Total Body Clearance for Dose Interval (Biological Clearance Rate)\tfused kidney (Kidney)\tGerminal Center B Cell-Like Gene Expression Signature (Gene Signature)\tHereditary Complement Deficiency Diseases (Disease or Syndrome)\t3-hydroxy-N,N-dimethylcrotonamide dimethyl phosphate (Organic Chemical)", + "output": "3-hydroxy-N,N-dimethylcrotonamide dimethyl phosphate (Organic Chemical)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had trouble with their coordination.\nConcepts: interleukin-17E receptor binding activity (Molecular Function)\tTrouble with Coordination (Intellectual Product)\tFAC07106 (Intellectual Product)\tProtein Kinase Inhibitor (Amino Acid, Peptide, or Protein)\tNucleus princeps colliculi inferioris (Body Part, Organ, or Organ Component)", + "output": "Trouble with Coordination (Intellectual Product)" + }, + { + "input": "Definition: Plant described as a horizontal stem that is fleshy or semi-woody and lies along the top of the ground.\nConcepts: aniline dye (Organic Chemical)\tStolon (Plant)\tRefractory Hepatoblastoma (Refractory Childhood Malignant Neoplasm)\tMembranes (Cytology)\tKnowledge Level (Cognitive function feature)", + "output": "Stolon (Plant)" + }, + { + "input": "Definition: something described as a form of liver inflammation caused by the hepatitis G virus.\nConcepts: Rat-1 Cells (Rat Cell Line)\tStage I Esophageal Squamous Cell Cancer (Neoplastic Process)\tviral hepatitis G infection (Disease or Syndrome)\tHow Important Standard Treatment Improves Symptoms (Clinical or Research Assessment Question)\tFocal Adhesion Associated Protein Tyrosine Kinase pp125FAK (alcohol phosphotransferase)", + "output": "viral hepatitis G infection (Disease or Syndrome)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in amino acid metabolism, liver gluconeogenesis and the homeostasis of fatty acid metabolism and storage.\nConcepts: Cocksfoot Grass Pollen IgG (Laboratory Procedure)\tMelanotransferrin wt Allele (Gene or Genome)\tBiotene Dental Chewing Gum (Clinical Drug)\tBIMSE - benign infantile focal epilepsy with midline spikes and waves during sleep (Disease or Syndrome)\tGPT2 (Transferase Gene)", + "output": "GPT2 (Transferase Gene)" + }, + { + "input": "Definition: Enzymopathy described as an autosomal recessive inherited disorder caused by mutations in the BCKDHA, BCKDHB, DBT, and DLD genes. It is characterized by a deficiency of branched-chain alpha-keto acid dehydrogenase complex, leading to accumulation of metabolites in the body fluids. The name of the disease derives from the sweet odor of the urine in infants, reminiscent of maple syrup. Signs and symptoms usually appear in infancy and include lethargy and developmental delays. If untreated, it may lead to seizures, coma, and death.\nConcepts: Bifocal (Spatial Concept)\tregulation of timing of exogen (regulation of hair follicle maturation)\tdisease; maple-syrup-urine (Rare Non-Neoplastic Disorder)\tAnalyzers, Point-of-Care, Whole Blood, Multianalyte (Analyzers, Point-of-Care, Whole Blood)\tDEAD Box Protein 31 (Amino Acid, Peptide, or Protein)", + "output": "disease; maple-syrup-urine (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: something described as a study that assesses variation in DNA sequence, usually within a single gene, and its effect on drug response.\nConcepts: Gangrene (Musculoskeletal necrosis and vascular insufficiency)\tOTUDP SYNDROME (Autosomal dominant hereditary disorder)\tPharmacogenomic Study (Human Pharmacology Study)\tPain Score 10 (Finding)\tMicrotechnologies (Miniaturization)", + "output": "Pharmacogenomic Study (Human Pharmacology Study)" + }, + { + "input": "Definition: Molecular Function described as loss of detectable antigen from the surface of a cell after incubation with antibodies. This is one method in which some tumors escape detection by the immune system. Antigenic modulation of target antigens also reduces the therapeutic effectiveness of treatment by monoclonal antibodies.\nConcepts: Chest Pain - Cardiac (Cardiac Disorders, CTCAE)\tregulation of systemic arterial blood pressure by local renal renin-angiotensin (Organism Function)\tUnit of Weight (Quantitative Concept)\tAntigenic Modulations (Molecular Function)\textrinsic apoptotic signaling pathway via death domain receptors (Cell Function)", + "output": "Antigenic Modulations (Molecular Function)" + }, + { + "input": "Definition: Asteraceae described as a plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).\nConcepts: Septa - device (Plate Device)\tDental Educations, Continuing (Educational Activity)\tstevia (Plant)\tresponse to capsazepine (Cell Function)\tGoiter, nodular (Mass of thyroid gland)", + "output": "stevia (Plant)" + }, + { + "input": "Definition: S-adenosylmethionine-dependent methyltransferase activity described as catalysis of the reaction: S-adenosyl-L-methionine + kaempferol = S-adenosyl-L-homocysteine + H(+) + kaempferide.\nConcepts: Grounded Theory (Methodology)\tFeel Like Doing All Sorts of Nice Things (Intellectual Product)\tGastrointestinal Stromal Tumor pN1 TNM Finding v8 (Finding)\tS-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity (O-methyltransferase activity)\tmacrosomia-obesity-macrocephaly-ocular abnormality syndrome (Disease or Syndrome)", + "output": "S-adenosyl-L-methionine:flavonoid 4'-O-methyltransferase activity (O-methyltransferase activity)" + }, + { + "input": "Definition: Fusion Protein Expression described as expression of a fusion protein that results from a t(9;11)(p22;q23) translocation, which involves the human genes KMT2A and MLLT3 and is associated with many leukemias.\nConcepts: stephania/han fang ji (Oriental herbs and natural substances letter S)\tMGC7807 (Ubiquitin-Transferase Gene)\ttherapy play (Therapeutic or Preventive Procedure)\talpha-copaene metabolic process (Molecular Function)\tMLL-AF9 Fusion Protein Expression (Cell or Molecular Dysfunction)", + "output": "MLL-AF9 Fusion Protein Expression (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Intellectual Product described as unified Parkinson's Disease Rating Scale - Modified Hoehn and Yahr Staging.\nConcepts: CLOT FACTOR II PROTHROM SPEC (Laboratory Procedure)\tFACT-B Version 4 - I Have Accepted My Illness (Intellectual Product)\tUPD143 (Intellectual Product)\testablishment or maintenance of epithelial cell apical/basal polarity (Cell Function)\tTherapeutic Tumor Infiltrating Lymphocytes (Antineoplastic Immune Cell)", + "output": "UPD143 (Intellectual Product)" + }, + { + "input": "Definition: something described as terminology used in support of the data collection efforts of the Clinical Proteomic Tumor Analysis Consortium (CPTAC) with the focus on Liver Hepatocellular Carcinoma Baseline Form data.\nConcepts: MPO gene (Oxidoreductase Gene)\tRoot Resorptions (Tooth Resorption)\tCPTAC Liver Hepatocellular Carcinoma Baseline Form (CPTAC Baseline Medical Forms Terminology)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Inversion 16 [inv (16)(p13q22)] CBFB/MYH11 (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Inversion)\tErections Sufficient for Intercourse, but Some Reduction in Firmness (Finding)", + "output": "CPTAC Liver Hepatocellular Carcinoma Baseline Form (CPTAC Baseline Medical Forms Terminology)" + }, + { + "input": "Definition: something described as a family of proteins that function as a regulatory beta subunit for the 5'-AMP-activated protein kinase (AMPK) protein complex. AMPK is a heterotrimeric protein kinase complex that plays a key role in regulating cellular energy metabolism and is comprised of a catalytic alpha subunit and non-catalytic beta and gamma subunits. The beta subunit exists as two isoforms, each is encoded by a separate gene.\nConcepts: Abnormal CSF/serum albumin ratio (Abnormality of the cerebrospinal fluid)\tenzyme active site formation via O-sulfo-L-serine (enzyme active site formation)\tAMPKbeta (Protein Complex Subunit)\tadenylate cyclase activator activity (Molecular Function)\tCough (Intellectual Product)", + "output": "AMPKbeta (Protein Complex Subunit)" + }, + { + "input": "Definition: Vulvar Neuroendocrine Carcinoma described as a neuroendocrine carcinoma that arises from the vulva. It is characterized by the presence of malignant small cells with neuroendocrine differentiation. Most small cell neuroendocrine carcinomas of the vulva are Merkel cell carcinomas.\nConcepts: alpha1beta1, Integrin (Amino Acid, Peptide, or Protein)\tcellular response to dexamethasone stimulus (response to dexamethasone)\tcoenzyme M biosynthesis (coenzyme M metabolic process)\tantimicrobial peptide biosynthetic process (Peptide Biosynthesis)\tVulvar Small Cell Carcinoma (Neoplastic Process)", + "output": "Vulvar Small Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as life-threatening consequences; urgent intervention indicated\nConcepts: SENSORY DISTURBANCE (physical symptom)\tRADIOIMMUNOASSAY, ANDROSTENEDIONE (Indicator, Reagent, or Diagnostic Aid)\tAmendment Signature Page (Document type)\tGrade 4 Hypophysitis, CTCAE (Hypophysitis, CTCAE)\tmesenchymal stem cell differentiation involved in nephron morphogenesis (Cell Function)", + "output": "Grade 4 Hypophysitis, CTCAE (Hypophysitis, CTCAE)" + }, + { + "input": "Definition: Common nursing interventions II described as managing and/or assisting a patient in complying with his or her prescribed and/or suggested therapy and/or treatment.\nConcepts: Flurbiprofen [oropharyngeal] (Carbonic Anhydrase Inhibitors)\trnax perform compliance care (rnrx personal care)\tCRQ02-Felt Frustrated or Impatient (Intellectual Product)\tCongenital central hypothyroidism due to thyrotropin-releasing hormone receptor deficiency (Congenital central hypothyroidism)\tmesonephric glomerular visceral epithelial cell fate commitment (Cell Function)", + "output": "rnax perform compliance care (rnrx personal care)" + }, + { + "input": "Definition: steroid hormone analog described as synthetic or natural chemical compounds which resemble naturally occurring sex hormones in structure and/or function.\nConcepts: sex hormone analog (Organic Chemical)\tImmature Neutrophils to Leukocytes Ratio Measurement (Blood Cell Count Ratio Measurement)\tInfiltrating Lobular Carcinoma of Breast (Invasive carcinoma of breast)\t(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol (Stilbenes)\tNeurexin-2 Isoform 1a (Biologically Active Substance)", + "output": "sex hormone analog (Organic Chemical)" + }, + { + "input": "Definition: Physiologic Function described as any process involved in the maintenance of an internal steady state of trivalent inorganic anions within an organism or cell.\nConcepts: trivalent inorganic anion homeostasis (Physiologic Function)\tSkeletal System of the Limb (Skeletal system)\tpassing wind (Finding of flatus)\typTNM Finding (Cancer TNM Finding Category)\tUDP-GlcNAc-2-epimerase activity (racemase and epimerase activity, acting on carbohydrates and derivatives)", + "output": "trivalent inorganic anion homeostasis (Physiologic Function)" + }, + { + "input": "Definition: Disease or Syndrome described as disease of skin in someone with Lupus erythematosis, though not necessarily systemic or subacute\nConcepts: Interactive Media (Review [Publication Type])\tLupus Erythematosus, Cutaneous (Noninfectious, erythematous, papular AND/OR squamous disease)\tvesicle transport along microtubule (organelle transport along microtubule)\tmurein hydrolase activity (carbon-oxygen lyase activity, acting on polysaccharides)\tLimitation of Use Based on Duration of Use (Limitation of Use)", + "output": "Lupus Erythematosus, Cutaneous (Noninfectious, erythematous, papular AND/OR squamous disease)" + }, + { + "input": "Definition: regulation of protein localization to chromatin described as any process that activates or increases the frequency, rate or extent of protein localization to chromatin.\nConcepts: Yes protein, human (src-Family Kinases)\tpositive regulation of protein localisation to chromatin (positive regulation of cellular protein localization)\t17\u03b1-Ethynylestr-4-ene-3\u03b2,17\u03b2-diol acetate (Organic Chemical)\tInteger Number (Data Type - Quantity)\tBile alcohols (Organic Chemical)", + "output": "positive regulation of protein localisation to chromatin (positive regulation of cellular protein localization)" + }, + { + "input": "Definition: something described as avoiding social or emotional involvement\nConcepts: parathyroid hormone-responsive B1 protein, human (Biologically Active Substance)\tSoftware, Video System, Endoscopic (Intellectual Product)\ttesevatinib (Angiogenesis Inhibitors)\tWithdrawal (Mental Process)\tCEFAZAFLUR SODIUM (Pharmacologic Substance)", + "output": "Withdrawal (Mental Process)" + }, + { + "input": "Definition: Intellectual Product described as hamilton Depression Rating Scale 6 - Self-Report Version - (6)=Tiredness and pains per clinician version: How you have been feeling over the past three days, including today.\nConcepts: Cytospin Slide (Smear sample)\ttrnsdntl med8xn Nres crse gr (Therapeutic or Preventive Procedure)\tactivation of immune response (Organism Function)\tHAM-D6 Self-Report Version - Tiredness and Pains (HAM-D6 Self-Report Version Questionnaire Question)\tPhosphoric acid, zinc salt (Dental Cement Material)", + "output": "HAM-D6 Self-Report Version - Tiredness and Pains (HAM-D6 Self-Report Version Questionnaire Question)" + }, + { + "input": "Definition: G Protein-Coupled Receptor Genes described as this gene is involved in the regulation of vasoactive intestinal peptide (VIP)- and pituitary adenylate cyclase-activating peptide (PACAP)-mediated signaling.\nConcepts: protein-FMN linkage via 3'-(8alpha-FMN)-L-histidine (Molecular Function)\tstruma; multinodular (Neoplasms)\tInferior genial spine (Body Part, Organ, or Organ Component)\tiRECIST (Response Evaluation Criteria in Solid Tumors)\tVIP and PACAP receptor 2 (G Protein-Coupled Receptor Genes)", + "output": "VIP and PACAP receptor 2 (G Protein-Coupled Receptor Genes)" + }, + { + "input": "Definition: Social Behavior described as emotional or behavioral responses to unfamiliar persons. Used for all age groups.\nConcepts: Stranger Reactions (Interpersonal Relations)\tphytonadione biosynthetic process (vitamin biosynthetic process)\tPERCENT VOLUME/VOLUME (Quantitative Concept)\tMajor Help to Transfer (Clinical or Research Assessment Answer)\tSNF2L3 (Gene or Genome)", + "output": "Stranger Reactions (Interpersonal Relations)" + }, + { + "input": "Definition: New client in-facility with or without ICD diagnosis described as using Oriental diagnostic methods in a simple, 10-minute, in-facility meeting to assess the health status of a new Oriental medicine client and develop an Oriental medicine treatment plan.\nConcepts: Eating at a Restaurant (Clinical or Research Assessment Question)\tCIS Nations (Asia)\tNon-toxic diffuse goiter (Endemic goiter)\tIn-facility simple new Oriental medicine intake 10 minutes (Health Care Activity)\tRoman Catholic (Religious Group)", + "output": "In-facility simple new Oriental medicine intake 10 minutes (Health Care Activity)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a radiotracer composed of a pegylated, dimeric arginine-glycine-aspartic acid (RGD) peptide (PRGD2), radiolabeled, via the chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), to a fluorine F 18-aluminum complex (AlF), with potential alphaVbeta3 integrin (vitronectin receptor) imaging activity using positron emission topography (PET). Upon administration, the RGD moiety of fluorine F 18 alfatide II selectively binds to alphaVbeta3 integrin. During PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is upregulated in tumor vessel endothelial cells and has been associated with neovascularization, differentiation, proliferation of tumor cells, and metastasis. Pegylation provides improved drug penetration into tumors and decreases drug clearance, thereby increasing efficacy while lowering systemic toxicity.\nConcepts: 18F-alfatide II (Radioconjugate)\tplant-type cell wall biogenesis (Cell Function)\tepisodic paroxysmal; anxiety (Anxiety)\tEndomysium (Striated muscle fasciculus)\tPVRGF (Quantitative Concept)", + "output": "18F-alfatide II (Radioconjugate)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Have you started to work out or worked out the details of how to kill yourself? Do you intend to carry out this plan? (Since Study Start).\nConcepts: immunotoxicity (Immunology)\tC-SSRS Already Enrolled Subjects - Active Suicidal Ideation With Specific Plan and Intent (Intellectual Product)\tEskine (Amino Acid, Peptide, or Protein)\tTotal laryngectomy (Complete excision)\tPQL06-Family Has Lot of Problems (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)", + "output": "C-SSRS Already Enrolled Subjects - Active Suicidal Ideation With Specific Plan and Intent (Intellectual Product)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Kidney Symptom Index-15 - I feel fatigued.\nConcepts: gibberellin binding (Molecular Function)\tcellular response to red light (Cell Function)\tanti-PD-1/anti-CTLA-4 XmAb20717 (Immunologic Factor)\tFAC039-I Feel Fatigued (FKSI-15 Questionnaire Question)\tpoly(hydroxyalkanoate) metabolism (organic substance metabolic process)", + "output": "FAC039-I Feel Fatigued (FKSI-15 Questionnaire Question)" + }, + { + "input": "Definition: Infancy, childhood and adolescence psychiatric disorders NEC described as persistent difficulties in the social uses of verbal and nonverbal communications.\nConcepts: Xinmailong (Cardiotonic Agents)\tenzyme active site formation via L-cysteine sulfenic acid (Molecular Function)\tglucuronolactone reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tSocial (pragmatic) communication disorder (Communication impairment)\tMyxobolus, NOS (Myxosporea)", + "output": "Social (pragmatic) communication disorder (Communication impairment)" + }, + { + "input": "Definition: Pharmacologic Substance described as a drug being studied to make cancer cells less resistant to the effects of chemotherapy.\nConcepts: E2F transcription factor 5 (Gene or Genome)\tMedium (Substance)\tCan Remember New Things (Findings-Based Question)\tBIRICODAR DICITRATE (Organic Chemical)\tearly stripe melanocyte cell differentiation (Cell Function)", + "output": "BIRICODAR DICITRATE (Organic Chemical)" + }, + { + "input": "Definition: Cell Component described as a cohesin complex that mediates sister chromatid cohesion in the nucleus during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.\nConcepts: DC-DEFIBRILLATOR, LOW-ENERGY, (Medical Device)\tNeoplasm benign;spleen (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE HEMATOPOIETIC AND IMMUNE SYSTEMS)\tupregulation of plasma membrane raft polarization (regulation of plasma membrane raft polarization)\t4-methyl-N-(3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl)-3-(4-(pyrazin-2-yl)pyrimidin-2-ylamino)benzamide hydrochloride (Pharmacologic Substance)\tnuclear meiotic cohesin complex (nuclear cohesin complex)", + "output": "nuclear meiotic cohesin complex (nuclear cohesin complex)" + }, + { + "input": "Definition: something described as integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.\nConcepts: Pump, H+ (Enzyme)\tCatheters, Chorionic Villus Sampling (Medical Device)\tdrinking behaviour (Feeding behaviors)\tvery-low-density lipoprotein particle (Cell Component)\tbleomycin/cytarabine/prednisone/vincristine (Regimen Used to Treat Hodgkin Lymphoma)", + "output": "Pump, H+ (Enzyme)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.\nConcepts: Acquired Phrenic Nerve Palsy (Phrenic nerve paralysis)\tagmatine formation (Molecular Function)\tPodospora anserina (Podospora)\tregulation of cardiac ventricle formation (regulation of cardiac ventricle development)\tInterosseous muscular atrophy (Finding)", + "output": "agmatine formation (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question associated with the SGRQ Past 4 Weeks Version questionnaire.\nConcepts: Within 5 Minutes (Finding)\tSt George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question (Intellectual Product)\tPlasmacytoma, NOS (Malignant Neoplasms)\tASCRINVACUMAB (Pharmacologic Substance)\tEOR0206 (Intellectual Product)", + "output": "St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: Finding described as suicidal ideation with no specific plan or intent\nConcepts: methionyl glutamyl tRNA synthetase complex (Cell Component)\tCooperatives, Practitioner (Health Care Activity)\tAlginate Mixing Systems (Dental Equipment and Supplies)\tLung Cancer cM1a TNM Finding v8 (Finding)\tGrade 2 Suicidal Ideation, CTCAE (Finding)", + "output": "Grade 2 Suicidal Ideation, CTCAE (Finding)" + }, + { + "input": "Definition: something described as a unit of concentration equal to liter per day divided by milligram per meter squared per day.\nConcepts: Prostate Retraction Implants (Non-Active Implantable Devices)\tDerivation, Fermentation, Disposable Bags (Laboratory Procedure)\tMilliliter per Day per Microgram per Meter Squared per Day (Unit of Dose Calculation)\tmucocele; salivary gland (Cyst of salivary gland)\tpain syndrome myofascial (Chronic inflammatory disorder)", + "output": "Milliliter per Day per Microgram per Meter Squared per Day (Unit of Dose Calculation)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the most typical number of times an individual has or had to get up to urinate from the time they went to bed at night until the time they got up in the morning.\nConcepts: Locally Advanced Squamous Cell Carcinoma of the Nasal Cavity and Paranasal Sinus (Locally Advanced Head and Neck Squamous Cell Carcinoma)\t{Log10 copies}/ml (Quantitative Concept)\tERBB signaling pathway (Signal Transduction Pathways)\tPerformed Observation Result Outcome (Finding)\tHow Many Times Typically Get Up to Urinate During Nighttime (Intellectual Product)", + "output": "How Many Times Typically Get Up to Urinate During Nighttime (Intellectual Product)" + }, + { + "input": "Definition: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor described as catalysis of the reaction: N,N-dimethylglycine + H(2)O + O(2) = formaldehyde + H(2)O(2) + sarcosine.\nConcepts: Mahvash Syndrome (Neoplastic Syndromes, Hereditary)\tdimethylglycine oxidase activity (oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs TNM Finding v8 (Soft Tissue Sarcoma TNM Finding v8)\tVaginal Carcinoma pT3 TNM Finding v8 (Finding)\tthermospermine metabolic process (Molecular Function)", + "output": "dimethylglycine oxidase activity (oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T-cells. The family is separated into group 1, expressed on cells specialized for antigen presentation, and group 2, expressed on a wider variety of cells.\nConcepts: branch cell fate determination (cell fate determination)\tCardaminopsis Hayek (Brassicaceae)\tdown-regulation of activated CD4-positive, alpha-beta T lymphocyte apoptotic process (Cell Function)\tDifferentiation Antigen CD1-Alpha-3 (Immunologic Factor)\tPODCI2-Up Extremity/Phys Function Scale (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "Differentiation Antigen CD1-Alpha-3 (Immunologic Factor)" + }, + { + "input": "Definition: something described as any bacterial organism that can be assigned to the species Escherichia fergusonii.\nConcepts: congenital cataract with ataxia and deafness syndrome (Auditory system hereditary disorder)\tEscherichia fergusonii (Escherichia)\tAtaxin-10 (Amino Acid, Peptide, or Protein)\tblood protein (Amino Acid, Peptide, or Protein)\tRecurrent Cancer of Hypopharynx (Hypopharyngeal neoplasms malignant and unspecified)", + "output": "Escherichia fergusonii (Escherichia)" + }, + { + "input": "Definition: something described as systems designed to produce contusions (e.g., on brain or spine) in laboratory research animals (e.g., rats and mice) to allow researchers to evaluate the process of injury to anatomical structures. These devices usually consist of some type of contusion-producing standard force pointed impactor positioned above a platform containing restraints to hold an anesthetized animal in position, and an electric control cabinet to precisely regulate the forces applied (impact velocity, depth and dwell time). Some impactors also have an integral stereotactic positioning system for the animal so that lesions may be precisely reproduced in more than one animal or more than one time.\nConcepts: IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Tube, Broth (Medical Device)\tPeriodontal Splint (Periodontal Prosthesis)\tShields, X-Ray, Other (Medical Device)\tHUSI-I (SLPI gene)\tImpactor Systems, Animal (Research Device)", + "output": "Impactor Systems, Animal (Research Device)" + }, + { + "input": "Definition: something described as catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine.\nConcepts: phosphatic acid phosphatase activity (Molecular Function)\tDifficulty Falling Asleep Score 3 (Difficulty Falling Asleep Scale)\tConverter Device (Device associated with converters)\tpantothenate hydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tTechnetium Tc99m mertiatide (Organotechnetium Compounds)", + "output": "pantothenate hydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)" + }, + { + "input": "Definition: Kidney Diseases described as nephrocalcinosis is the deposition of calcium salts in renal parenchyma.\nConcepts: Unconscious, Psychological (Personality Development)\tNephrocalcinoses (Kidney lesion)\tPRIMA-1 Analog APR-246 (Antineoplastic Agents)\tpreviously treated myelodysplastic syndromes (Adult Myelodysplastic Syndrome)\tIron Excretion Rate (Quantitative Concept)", + "output": "Nephrocalcinoses (Kidney lesion)" + }, + { + "input": "Definition: A [Preparations] described as an orally bioavailable inhibitor of the nonstructural protein 3 (NS3), with potential activity against hepatitis C virus (HCV). Upon administration, asunaprevir binds to the active center of the HCV NS3 and prevents NS3 protease-mediated polyprotein maturation. This disrupts the processing of viral proteins required for HCV replication. NS3, a serine protease, is essential for the proteolytic cleavages within the HCV polyprotein and plays a key role during HCV viral RNA replication. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family.\nConcepts: Folate Hydrolase 1 Measurement (Laboratory Procedure)\tvestibulomotor regions (Body Location or Region)\tcyclopropanecarboxamide, N-((1,1-dimethylethoxy)carbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)- (Retroviral protease inhibitor)\tG1/S-Specific Cyclin E2 (Amino Acid, Peptide, or Protein)\tcornea; scar (Corneal structural change, deposit and degeneration)", + "output": "cyclopropanecarboxamide, N-((1,1-dimethylethoxy)carbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethenyl-, (1R,2S)- (Retroviral protease inhibitor)" + }, + { + "input": "Definition: Immunoglobulin Isotypes described as pentameric immunoglobulin largely confined to the intravascular pool and the predominant early antibody frequently seen in the immune response to antigenically complex infectious organisms.\nConcepts: 2'-fluoro-5-ethyl-1-beta-D-arabinofuranosyluracil (pyrimidine analog)\tGrade 3 Esophagitis (Finding)\tEnzymologic Gene Expression Regulation (Gene Expression Regulation)\tGermline Micronuclei (Cell Component)\tImmunoglobulin M (Antibodies)", + "output": "Immunoglobulin M (Antibodies)" + }, + { + "input": "Definition: Basic interpersonal interactions described as giving and reacting appropriately to signs and hints that occur in social interactions.\nConcepts: corticospinal neuron axon guidance through the cerebral peduncle (Axon Guidance)\tUnraveled Material (Material Degradation)\tN (2-(((5-((Dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine (Drug allergens)\tSocial cues in relationships (Social Behavior)\tmodulation of host vacuole organization by symbiont (Organism Function)", + "output": "Social cues in relationships (Social Behavior)" + }, + { + "input": "Definition: Language described as a Cariban language spoken by the Kalina people of South America.\nConcepts: superior temporal area 22 (Body Part, Organ, or Organ Component)\tVFQ25-Interviewer Administered Format - Are You Currently Driving (Intellectual Product)\tSkull Trephine Blades (Blades, Trephine, Surgical)\tinvoluntary skeletal muscle contraction (Contraction skeletal muscle)\tCarib Language (Language spoken)", + "output": "Carib Language (Language spoken)" + }, + { + "input": "Definition: regulation of leukocyte activation described as any process that modulates the frequency or rate of myeloid dendritic cell activation.\nConcepts: box C/D snoRNA processing (snoRNA processing)\tSF3B1 Thr663Xxx (SF3B1 Protein Variant)\tregulation of myeloid dendritic cell activation (Cell Function)\tGBM multi-antigen vaccine IMA950 (Immunologic Factor)\twpws (Accessory Atrioventricular Bundle)", + "output": "regulation of myeloid dendritic cell activation (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment, I was concerned about: missing important family events at home such as birthdays, weddings, funerals, graduations, etc.\nConcepts: DRRI1-L: Missing Family Events at Home (Intellectual Product)\tGrade 4 Atrial Flutter, CTCAE (Finding)\t25-Hydroxycholecalciferol 1-Hydroxylase (Enzyme)\tX-linked mental retardation 4 (Disease or Syndrome)\tKinked Tail (Finding)", + "output": "DRRI1-L: Missing Family Events at Home (Intellectual Product)" + }, + { + "input": "Definition: plastid intermembrane space described as the region between the inner and outer lipid bilayers of a chromoplast envelope.\nConcepts: PLASMA, COAGULATION CONTROL (Indicator, Reagent, or Diagnostic Aid)\tchromoplast intermembrane space (plastid intermembrane space)\tEMA-CE Regimen (Regimen Used to Treat Gestational Trophoblastic Tumor)\tLeber plus disease (Optic Atrophy, Hereditary, Leber)\tP Glycoprotein 4 Positive (Laboratory or Test Result)", + "output": "chromoplast intermembrane space (plastid intermembrane space)" + }, + { + "input": "Definition: Non-organ specific antibody described as autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.\nConcepts: Retinopathy of Prematurity in Zone 2 (Retinopathy of Prematurity Finding)\tSTL (RNF217-AS1 gene)\tcentral nervous system myelination (Cell Function)\tANF (Functional Immunologic Units)\tear hammer (Malleus)", + "output": "ANF (Functional Immunologic Units)" + }, + { + "input": "Definition: Organic Chemical described as brand name of an antibacterial cream\nConcepts: Cone Dystrophies, Progressive (retinal dystrophy primarily involving sensory retina)\tSSD (Pharmacologic Substance)\tDasatinib-containing product (D [Preparations])\tHepatitis GB virus C/G (Hepatitis Viruses)\tventriculo bulbo valve morphogenesis (heart valve morphogenesis)", + "output": "SSD (Pharmacologic Substance)" + }, + { + "input": "Definition: melatonin receptor binding described as interacting selectively and non-covalently with a H9 melatonin receptor.\nConcepts: HAAH Lambda phage Vaccine SNS-301 (Cancer Vaccines)\tFemale Reproductive System Finding (Finding)\tKvLQT Potassium Channels (Biologically Active Substance)\tgraft versus tumor induction (Pathologic Processes)\tH9 melatonin receptor binding (melatonin receptor binding)", + "output": "H9 melatonin receptor binding (melatonin receptor binding)" + }, + { + "input": "Definition: Caries described as arrested carious lesion that is not advancing.\nConcepts: alpha Defensin (Pharmacologic Substance)\tup regulation of cell organization (regulation of cellular component organization)\tWD domain binding (protein domain specific binding)\tFail-Safe System Device (Manufactured Object)\tNon-active caries (Disease or Syndrome)", + "output": "Non-active caries (Disease or Syndrome)" + }, + { + "input": "Definition: regulation of intracellular steroid hormone receptor signaling pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.\nConcepts: negative regulation of intracellular steroid hormone receptor signaling pathway (regulation of intracellular steroid hormone receptor signaling pathway)\tUbiquitin--protein ligase (Amino Acid, Peptide, or Protein)\tpositive regulation by symbiont of host catalytic activity (positive regulation of catalytic activity in other organism involved in symbiotic interaction)\tReceptor, Endothelin A (Endothelin Receptor)\talpha Helical Protein Conformation (Spatial Concept)", + "output": "negative regulation of intracellular steroid hormone receptor signaling pathway (regulation of intracellular steroid hormone receptor signaling pathway)" + }, + { + "input": "Definition: Spatial Concept described as of, or pertaining to, the prostate.\nConcepts: dopamine binding (Molecular Function)\tOphthalmic Implants, Iris (Medical Device)\tPOLYCYSTIC LIVER DISEASE 1 WITH OR WITHOUT KIDNEY CYSTS (Congenital Abnormality)\tmevaldate reductase (NADPH) activity (mevaldate reductase activity)\tProstatic (Anatomy Qualifier)", + "output": "Prostatic (Anatomy Qualifier)" + }, + { + "input": "Definition: Transcription Regulatory Protein described as retinoblastoma-associated protein (928 aa, ~106 kDa) is encoded by the human RB1 gene. This protein plays a role in the regulation of cell cycle progression.\nConcepts: Rb (Specific antigen)\tnuclear poly(A)-dependent antisense transcript catabolic process (nuclear polyadenylation-dependent ncRNA catabolic process)\tbipotassium chromate (Indicator, Reagent, or Diagnostic Aid)\tSubaortic ventricular septal bulge (Anatomical Abnormality)\tMisassembled by Users (Event)", + "output": "Rb (Specific antigen)" + }, + { + "input": "Definition: Quantitative Concept described as the difference between Cmax and Cmin standardized to Cmin within a dosing interval.\nConcepts: Structure of submental vein (Structure of half of neck lateral to midsagittal plane)\tConstructional Praxis: Cube (ADAS-Cog CDISC Version Questionnaire Question)\tPK Swing (Quantitative Concept)\tHHS (Disease or Syndrome)\tArticulatio tarsi transversa (Intertarsal joint structure)", + "output": "PK Swing (Quantitative Concept)" + }, + { + "input": "Definition: something described as a morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns. Necrotic changes and high mitotic activity are present.\nConcepts: Magnesium-rich Mineral Water (Dietary Supplements)\tPGD2 measurement (Prostaglandin measurement)\tAcquired Facial Nerve Palsy (Disease or Syndrome)\tCDC7L1 (Gene or Genome)\tTall Cell Variant Thyroid Gland Papillary Carcinoma (Papillary thyroid carcinoma)", + "output": "Tall Cell Variant Thyroid Gland Papillary Carcinoma (Papillary thyroid carcinoma)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the BUERS clinical classification.\nConcepts: USTILAGO AVENAE (Fungus)\tBUERS Clinical Classification Question (Clinical or Research Assessment Question)\tHomeo Box A1 Gene (HOXA1 gene)\tADAPTER, A-V SHUNT OR FISTULA (Medical Device)\tZirconium Zr 89-labeled Envafolimab (Radioimmunoconjugates)", + "output": "BUERS Clinical Classification Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Branchial cleft cyst or fistula; preauricular sinus described as preauricular sinus is an occasional finding and most frequently appears as a small pit close to the anterior margin of the ascending portion of the helix. The opening has also been reported along the postero superior margin of the helix, the tragus or the lobule. Preauricular sinus may lead to the formation of a subcutaneous cyst that is intimately related to the tragal cartilage and the anterior crus of the helix.\nConcepts: sE-selectin (Laboratory Procedure)\tWATERMELON (Structured Product Labeling Flavor)\tProstheses, Upper Limb, Hand, Mechanical (Hand prosthesis)\tMitosis Modulators (Pharmacologic Substance)\tPREAURICULAR CYST (Musculoskeletal and connective tissue disorders of face, neck and jaw congenital)", + "output": "PREAURICULAR CYST (Musculoskeletal and connective tissue disorders of face, neck and jaw congenital)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Could the subject use public transportation to get places without help?\nConcepts: Carboplatin-Doxil (Therapeutic or Preventive Procedure)\tSkin Electrical Resistance-Based Screening Physiologic Analyzers (Medical Device)\tStage IIB Appendiceal Carcinoma AJCC v8 (Stage II Appendix Carcinoma AJCC v8)\tUHDR1-Public Transportation Without Help (Intellectual Product)\tBlast cells in blood (Finding)", + "output": "UHDR1-Public Transportation Without Help (Intellectual Product)" + }, + { + "input": "Definition: Radiation-Sensitizing Agents described as a synthetic radiopaque liquid form of perfluorooctyl bromide. Used as a contrast agent for magnetic resonance imaging (MRI), perflubron is also used as a liquid ventilation agent to improve pulmonary gas exchange and lung compliance and may be used in surgery to reduce or eliminate the need for a donor blood. Ventilation with perfluorocarbon fluid improves lung function in conditions involving surfactant deficiency and dysfunction, including respiratory distress syndrome and adult respiratory distress syndrome. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1422\" active clinical trials using this agent.\nConcepts: pfob (Indicator, Reagent, or Diagnostic Aid)\t5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid binding (Molecular Function)\tHYDROGENATED CASTOR OIL (Industrial Aid)\tElectronic Source Data (Intellectual Product)\tDefined Product Transport (Functional Concept)", + "output": "pfob (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Medical Device described as prepackaged collections of the devices and supplies (either custom or standard) needed for providing local anesthesia into the pudendal nerve located in the pudendal canal. Items in these kits usually include a procedure needle with a spacer, a metal trumpet needle, gauze pads, underpads, a sterilization indicator, and lidocaine. The kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Pudendal anesthesia kits and trays are intended for use during diagnostic and/or therapeutic procedures in the perineal area, especially during pregnancy, producing a pudendal nerve block.\nConcepts: acetyl-CoA:formate C-acetyltransferase activity (Molecular Function)\tpositive regulation of infection cushion formation on or near host (positive regulation of development of symbiont involved in interaction with host)\tLong-Term Potentiation Pathway (Homeostasis Regulation Pathway)\tProcedure Kit/Trays, Anesthesia, Pudendal (Procedure Kit/Trays, Anesthesia)\tH2BFR (Histone H2B Gene)", + "output": "Procedure Kit/Trays, Anesthesia, Pudendal (Procedure Kit/Trays, Anesthesia)" + }, + { + "input": "Definition: Device Labeled for Single Use described as handheld devices used as receptacles to hold beverages for consumption, medication in solid or liquid form, or other objects. Cups are typically taller than they are wide, made of glass, plastic, metal, or paper, and may be reusable or disposable.\nConcepts: virus (MeSH Russian)\tCup (Device Labeled for Single Use)\tFAC028-I Feel Sad (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)\tAppendix Carcinoma by AJCC v8 Stage (Carcinoma of the Appendix)\toptic lobe placode development (Organ or Tissue Function)", + "output": "Cup (Device Labeled for Single Use)" + }, + { + "input": "Definition: Biologically Active Substance described as regulatory elements of an operon to which activators or repressors bind thereby effecting the transcription of genes in the operon.\nConcepts: Carditis NOS (Mediastinitis)\tureteric peristalsis (Peristalsis)\tRegion, Genetic Operator (Molecular Sequence Data)\tFemale-to-Male Transsexual (Transsexual)\tfrtlt cnsltn couple ea.15min (Health Care Activity)", + "output": "Region, Genetic Operator (Molecular Sequence Data)" + }, + { + "input": "Definition: Negative Regulation of Microtubule Depolymerization described as any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.\nConcepts: DEMETON-O (Organic Chemical)\tspitting (Motor action of oral region)\tRadiofrequency Therapy Systems, Tissue Ablation, Endometrial (Radiofrequency Therapy Systems, Tissue Ablation)\tK ATP Associated Transient Neonatal Diabetes Mellitus (Transient neonatal diabetes mellitus)\tnegative regulation of axonemal microtubule depolymerization (regulation of plasma membrane bounded cell projection organization)", + "output": "negative regulation of axonemal microtubule depolymerization (regulation of plasma membrane bounded cell projection organization)" + }, + { + "input": "Definition: protein-lipid complex described as a spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph.\nConcepts: Traumatic haemorrhage (Hemorrhage)\tgallium Ga 68-NOTA-BBN-RGD (Radioconjugate)\tmethylthioalkylmalate dehydrogenase activity (Molecular Function)\tlipoprotein particle (Cell Component)\tImpedance Problem (Finding)", + "output": "lipoprotein particle (Cell Component)" + }, + { + "input": "Definition: Individual Behavior described as personal actions to understand, prevent, eliminate, or reduce the threats to health associated with tobacco use\nConcepts: Risk control behavior: tobacco use (Individual Behavior)\tColoring, Prosthesis (Therapeutic or Preventive Procedure)\tpeels (skin lesion morphology)\tPhysician Self Referral (Referral and Consultation)\tL-Iditol:NAD+ 2-oxidoreductase (Sugar Alcohol Dehydrogenases)", + "output": "Risk control behavior: tobacco use (Individual Behavior)" + }, + { + "input": "Definition: something described as facilitating therapeutic endurance exercise for a client to obtain, restore and/or improve his or her normal function of a body part or region that requires rehabilitation. Service is billed in 15-minute increments.\nConcepts: Droppers (Medical Device)\tEndurance therapeutic exercise individual each 15 minutes (Rehabilitative treatments and/or training)\tBreast Cancer 1 c.5265 5266insC (BRCA1 gene mutation)\tMeasured intake of alpha-linoleic acid in 24 hours (Quantitative Concept)\tVentriculo-peritoneal Shunts (Cerebrospinal fluid therapeutic procedures)", + "output": "Endurance therapeutic exercise individual each 15 minutes (Rehabilitative treatments and/or training)" + }, + { + "input": "Definition: something described as a representation of the exponential function described by the Salazar-Knowles equation, and an estimation of a subject's inspiratory capacity.\nConcepts: regulation of primary metabolic process (regulation of metabolism)\tSet of temporal veins (Body Part, Organ, or Organ Component)\tintegral component of muscle cell projection membrane (integral component of plasma membrane)\tAdverseEvent.treatmentEmergentIndicator (Functional Concept)\tSALKA (Pulmonary function tests)", + "output": "SALKA (Pulmonary function tests)" + }, + { + "input": "Definition: Pathologic Stage III Cutaneous Melanoma AJCC v8 described as stage IIIC includes: (T0, N2b, N2c, N3b or N3c); (T1a-T3a, N2c or N3a/b/c, M0); (T3b/T4a, Any N greater than or equal to N1, M0); (T4b, N1a-N2c, M0). T0: No evidence of primary tumor (e.g., unknown primary or completely regressed melanoma). Thickness: Not applicable. Ulceration status: Not applicable. T1a: Tumor measuring less than 0.8 mm in thickness. Ulceration status: Without ulceration. T1b: Tumor measuring less than 0.8 mm in thickness with ulceration, or 0.8-1.0 mm with or without ulceration. T2a: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: Without ulceration. T2b: Tumor measuring more than 1.0 and equal to or less than 2.0 mm in thickness. Ulceration status: With ulceration. T3a: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: Without ulceration. T3b: Tumor measuring more than 2.0 and equal to or less than 4.0 mm in thickness. Ulceration status: With ulceration. T4a: Tumor measuring more than 4.0 mm in thickness. Ulceration status: Without ulceration. T4b: Tumor measuring more than 4.0 mm in thickness. Ulceration status: With ulceration. N2b: Two or three nodal metastases at least one of which was clinically detected. Presence of in-transit, satellite, and/or microsatellite metastases: No. N2c: One clinically occult nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3b: Four or more nodal metastases, at least one of which was clinically detected, or presence of any number of matted nodes. Presence of in-transit, satellite, and/or microsatellite metastases: No. N3c: Two or more clinically occult nodal metastases. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N3a: Four or more clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1a: One clinically occult nodal metastasis (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. N1b: One clinically detected nodal metastasis. Presence of in-transit, satellite, and/or microsatellite metastases: No. N1c: No regional lymph node disease. Presence of in-transit, satellite, and/or microsatellite metastases: Yes. N2a: Two or three clinically occult nodal metastases (i.e., detected by sentinel lymph node biopsy). Presence of in-transit, satellite, and/or microsatellite metastases: No. M0: No evidence of distant metastasis. LDH level is not applicable.\nConcepts: Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 (Pathologic Stage III Cutaneous Melanoma AJCC v8)\tATPase-coupled azole transmembrane transporter activity (ATPase-coupled transmembrane transporter activity)\tInadequate psyllium intake (Inadequate bioactive substance intake)\tADL0103 (Intellectual Product)\tStaff Interest Primary Indicator (Primary Indicator)", + "output": "Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 (Pathologic Stage III Cutaneous Melanoma AJCC v8)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question associated with the AVPU clinical classification.\nConcepts: Lactulosum (HYPEROSMOTIC LAXATIVES)\tMultimedia Filing Cabinets (Manufactured Object)\tModerate to Late Preterm Infant (Age Group)\tAVPU Clinical Classification Question (Intellectual Product)\tStability Study Method Type Terminology (FDA Stability Data Standards Terminology)", + "output": "AVPU Clinical Classification Question (Intellectual Product)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that activates, maintains or increases the frequency, rate or extent of cardiac muscle growth.\nConcepts: EOG (Electrodiagnostic test)\tFAC01834 (FACT-LYM Version 4 Questionnaire Question)\tpositive regulation of heart muscle growth (positive regulation of heart growth)\tRecurrent Cancer of the Hypopharynx (Neoplastic Process)\tGYNECOL (Medicine)", + "output": "positive regulation of heart muscle growth (positive regulation of heart growth)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a monosodium L-glutamate stimulus.\nConcepts: Golgi-associated vesicle membrane (Cell Component)\tAlkylphospholipids (Pharmacologic Substance)\tcellular response to monosodium L-glutamate (cellular response to monosodium glutamate)\tCefoxitin, sodium (Beta-lactam, Cephalosporins)\tbenign Brenner tumor of ovary (Surface epithelial-stromal tumor)", + "output": "cellular response to monosodium L-glutamate (cellular response to monosodium glutamate)" + }, + { + "input": "Definition: Congenital heart disease described as a congenital heart defect characteizred by a specific combination of heart defects with a common atrioventricular valve, primum atrial septal defect and inlet ventricular septal defect.\nConcepts: Complete atrioventricular canal defect (Heart)\tdeaminase activity (hydrolase activity)\tVoriconazol (Triazoles)\tFocal aware autonomic seizure with urge to urinate/defecate (Focal aware autonomic seizure)\tStudy Resource Effective Date Range (Temporal Concept)", + "output": "Complete atrioventricular canal defect (Heart)" + }, + { + "input": "Definition: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor described as catalysis of the reaction: 3-hydroxyanthranilate + O(2) = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H(2)O(2).\nConcepts: 30-hydroxy-beta-amyrin 11-hydroxylase activity (Molecular Function)\t3-hydroxyanthranilate oxidase activity (Molecular Function)\tarthroconidium formation (anatomical structure formation involved in morphogenesis)\tAnterior thoracic region (Structure of thorax, including mediastinum and diaphragm)\tSinonasal Tract (Body Part, Organ, or Organ Component)", + "output": "3-hydroxyanthranilate oxidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Toddler Parent Report - In the past 7 days, how much of a problem has this been for your child: My child gets hurt accidentally.\nConcepts: regulation of sleep (regulation of circadian sleep/wake cycle)\tPQL1814 (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report - Long Time to Bathe or Shower (Intellectual Product)\tembryo sac morphogenesis (embryonic morphogenesis)\trelaxin (Peptide hormones and their metabolites and precursors)", + "output": "PQL1814 (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)" + }, + { + "input": "Definition: something described as it lies laterally to intermediate mesoderm.\nConcepts: negative regulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly (Physiologic Function)\tRibosome Subunit Gene (Gene or Genome)\tAG7 Positive (Positive Laboratory Test Result)\t1-naphthaldehyde:oxygen oxidoreductase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor)\tLateral plate mesoderm (Mesoderm)", + "output": "Lateral plate mesoderm (Mesoderm)" + }, + { + "input": "Definition: something described as catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate.\nConcepts: Swallowing G-code (Intellectual Product)\tPain Thresholds (Sensation observable)\tdi-trans,poly-cis-decaprenylcistransferase activity (prenyltransferase activity)\tPAFAHB (Gene or Genome)\thelicobacters (Bacterium)", + "output": "di-trans,poly-cis-decaprenylcistransferase activity (prenyltransferase activity)" + }, + { + "input": "Definition: Gene or Genome described as human GSTT1 wild-type allele is located in the vicinity of 22q11.23 and is approximately 8 kb in length. This allele, which encodes glutathione S-transferase theta-1 protein, is involved in the conjugation of reduced glutathione with both endogenous and exogenous hydrophobic electrophilic compounds. The GSTT1 null genotype is associated with an increased risk for the development of cancer.\nConcepts: GIC-1002 (Analgesics)\tGlutathione S-Transferase Theta 1 wt Allele (GSTT1 gene)\tOxyphil adenoma (Neoplasms benign site unspecified NEC)\tRate Setting and Review (Fees and Charges)\tIspaghula husk-containing product (Organic Chemical)", + "output": "Glutathione S-Transferase Theta 1 wt Allele (GSTT1 gene)" + }, + { + "input": "Definition: Region of intra-embryonic mesoderm described as it lies laterally to intermediate mesoderm.\nConcepts: epiphyseal growth plate (Structure of long bone)\tLateral Plate Mesoderm (Embryonic Structure)\tCoagulation disorder NOS (PLATELET,BLEEDING & CLOTTING DISORDERS)\tRisk for thermal injury (Finding)\tHIAP2 (Gene or Genome)", + "output": "Lateral Plate Mesoderm (Embryonic Structure)" + }, + { + "input": "Definition: Laboratory Procedure described as an analytical method for detecting and measuring FLUORESCENCE in compounds or targets such as cells, proteins, or nucleotides, or targets previously labeled with FLUORESCENCE AGENTS.\nConcepts: 2q21 (Cell Component)\tHPAFP (Abnormal presence of alpha-fetoprotein)\tFluorometric Analysis (Spectrometry)\tLate-onset isolated ACTH deficiency (Disease or Syndrome)\tPROJECTIONS PREDICTIONS (temporal distribution)", + "output": "Fluorometric Analysis (Spectrometry)" + }, + { + "input": "Definition: Disease or Syndrome described as a microdeletion occurring on the short (p) arm of chromosome 16 at a location designated p12.2. Common characteristics of this disease include developmental delay, delayed speech, intellectual disability, hypotonia, short stature, microcephaly, cardiac malformations, recurrent epilepsy, psychiatric and behavioural problems. Manifestations vary even among affected members of the same family. Inherited in an autosomal dominant pattern with incomplete penetrance, in almost all known cases the chromosomal change has been inherited from a parent\nConcepts: Antigens, Archaeal (Antigens)\tposterior lateral line neuromast hair cell morphogenesis (neuromast hair cell morphogenesis)\t2-(6'-methylthio)hexylmalate synthase activity (transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer)\t16p12.2 microdeletion syndrome (Deletion of part of short arm of chromosome 16)\tNicotinamide Methyltransferase (Amino Acid, Peptide, or Protein)", + "output": "16p12.2 microdeletion syndrome (Deletion of part of short arm of chromosome 16)" + }, + { + "input": "Definition: Metastatic Renal Pelvis Carcinoma described as renal pelvis urothelial carcinoma that has spread to another anatomical site.\nConcepts: Metastatic Renal Pelvis Urothelial Cancer (Metastatic Renal Pelvis Carcinoma)\tantibody jc virus (Antibody)\tBone Cancer pNX TNM Finding v7 (Finding)\tprotein phosphatase inhibitor activity (phosphatase inhibitor activity)\tRenal Epithelial Stromal Tumor (Kidney Mixed Epithelial and Stromal Tumor Family)", + "output": "Metastatic Renal Pelvis Urothelial Cancer (Metastatic Renal Pelvis Carcinoma)" + }, + { + "input": "Definition: something described as neonatal focal tonic seizure is a type of neonatal electro-clinical tonic seizure with a focal sustained increase in muscle tone, lasting a few seconds to minutes.\nConcepts: sergliflozin etabonate (Sodium-Glucose Transporter 2 Inhibitors)\tWeight reduction regimen or diet (Nutritional Support)\tXANTHOTOXIN (Fungal product)\tNeonatal focal tonic seizure (Neonatal electro-clinical tonic seizure)\tposterior nuclear complex (Thalamic Nuclei)", + "output": "Neonatal focal tonic seizure (Neonatal electro-clinical tonic seizure)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.\nConcepts: Under immunised (Immunization status)\tTabminder (Potency Unit)\tRECIST Partial Response (Finding)\tresponse to TCDD (response to organic cyclic compound)\tExtrahepatic Biliary Stasis (Finding of biliary tract)", + "output": "response to TCDD (response to organic cyclic compound)" + }, + { + "input": "Definition: Microtechnique described as thin layer deposition. Commonly used in integrated circuit fabrication.\nConcepts: Microdeposition (Research Activity)\tureter (Ureter)\tGLOVE, PATIENT EXAMINATION, SPECIALTY (Medical Device)\tOCULOMOTOR NERVE (Peripheral nerve of head and neck)\tMHB morphogenesis (Organism Function)", + "output": "Microdeposition (Research Activity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the part of the cerebral peduncle located dorsal to the substantia nigra in the midbrain ( Carpenter-1983 ). Defined by dissection, it is found in all vertebrates ( Swanson-2015 ).\nConcepts: Abnormality of the distal femoral epiphysis (Anatomical Abnormality)\tMidbrain tegmentum (Midbrain structure)\tTherapeutic plasmapheresis (BLOOD PROCEDURES AND TRANSFUSIONS)\tIVD Test Reagent/Kits, Immunoassay, Lipoprotein (IVD Test Reagent/Kits, Immunoassay)\tminimal change disease (Glomerulonephritis and nephrotic syndrome)", + "output": "Midbrain tegmentum (Midbrain structure)" + }, + { + "input": "Definition: Disease or Syndrome described as an autosomal recessive condition caused by mutation(s) in the AMPD1 gene, encoding AMP deaminase 1. The condition is characterized by exercise-induced muscle pain and/or fatigue, which may be associated with rhabdomyolysis and/or increased concentrations of creatinine kinase.\nConcepts: Protocol Chair at an Organization (Chairperson)\tregulation of natural killer cell cytokine production (regulation of natural killer cell mediated immunity)\tMYOADENYLATE DEAMINASE DEFICIENCY, MYOPATHY DUE TO (Metabolic myopathy)\t%(w/v) (Non-SI unit of concentration)\tdownregulation of smoothened signaling pathway (Molecular Function)", + "output": "MYOADENYLATE DEAMINASE DEFICIENCY, MYOPATHY DUE TO (Metabolic myopathy)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a preparation of autologous peripheral blood mononuclear cells (PBMCs) radiolabeled with indium In 111 with radioisotopic activity. Autologous PBMCs are isolated, expanded ex vivo, radiolabeled with indium In 111, and then infused back into the patient. Gamma scintigraphy may then be used to image gamma ray-emitting indium In 111 PBMCs localized in lymphoma tissue.\nConcepts: Intrathecal (Drug Administration Routes)\tIPAQ Short Last 7 Days Self-administered Format Version Questionnaire Question (Intellectual Product)\tHAQ-DI (Intellectual Product)\tDental Stick Dosage Form (Drug stick)\tindium In 111-labeled autologous peripheral blood mononuclear cells (Radioimmunoconjugates)", + "output": "indium In 111-labeled autologous peripheral blood mononuclear cells (Radioimmunoconjugates)" + }, + { + "input": "Definition: Antineoplastic Agents described as a drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells.\nConcepts: Inositol Triphosphate 5-Phosphatase (Amino Acid, Peptide, or Protein)\tregulation of prostaglandin synthesis (regulation of unsaturated fatty acid biosynthetic process)\tAntimetabolite (Antineoplastic Agents)\tlumen of vacuole with cell cycle-independent morphology (vacuolar lumen)\tIVD Test Reagent/Kits, Immunoassay, Lipoprotein-Associated Enzyme Phospholipase A2 (IVD Test Reagent/Kits, Immunoassay)", + "output": "Antimetabolite (Antineoplastic Agents)" + }, + { + "input": "Definition: Pharmacologic Substance described as an autologous therapeutic vaccine for the treatment of acute myelogenous leukemia. This vaccine is prepared from blood samples of patients following their first relapse. Tumor cells extracted from blood sample are modified with hapten, a process that makes the cells appear foreign to the patient's body and results in stimulating immune response against the cancer.\nConcepts: TF2F1 Gene (GTF2F1 gene)\tAutologous-Cell Leukemia Vaccine (Immunologic Factor)\tCollagenous gastritis (Gastritis)\tIMDC Poor Risk Group (Intellectual Product)\tDissertation, Academic as Topic (Publications)", + "output": "Autologous-Cell Leukemia Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: Plant described as an herb native to North America that has been used to prevent and treat the common cold and other respiratory infections. Echinacea may interfere with treatment that uses the immune system to fight cancer. The scientific names are Echinacea purpurea and Echinacea angustifolia.\nConcepts: PPBFTDS (Malignant Lung and Pleural Neoplasm)\tEchinacea Moench (Heliantheae)\tGrade 5 Neonatal Sinus Tachycardia (Neonatal Sinus Tachycardia, Adverse Event)\tkeratosis seborrheic (Neoplastic Process)\tTumor Cell Mobility (Tumor Expansion)", + "output": "Echinacea Moench (Heliantheae)" + }, + { + "input": "Definition: BRAF Exon 15 Mutation described as a complex substitution where the nucleotide sequence at positions 1799 and 1780 of the coding sequence of the BRAF gene has changed from thymine-guanine to adenine-thymine.\nConcepts: Hyperthermia - disorder (Physical Regulation Alteration)\tFunctional Communication (Research or Clinical Assessment Tool)\tresponse to nitrogen compound (response to chemical)\tBRAF NM 004333.4:c.1799 1800delTGinsAT (Cell or Molecular Dysfunction)\tIVD Test Reagent/Kits, Immunoassay, Immunology, Cytokine, Interleukin (Medical Device)", + "output": "BRAF NM 004333.4:c.1799 1800delTGinsAT (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Degree/license/certificate described as a postgraduate academic degree awarded after the completion of a program of one to three years in duration. This acknowledgment comprises about 4-6 years of university study in total with a professional engineering discipline that deals with the construction and design of public and private sector works such as bridges, roads, dams and buildings.\nConcepts: TK (Laboratory Procedure)\tcapsular ligament (Body Part, Organ, or Organ Component)\tMaster of Civil Engineering (Degree/license/certificate)\tMalaria Therapeutic Area User Guide v1.0 (Intellectual Product)\tCortex (Body Part, Organ, or Organ Component)", + "output": "Master of Civil Engineering (Degree/license/certificate)" + }, + { + "input": "Definition: Health care facility described as a medical center which is eligible to receive funding from Medicaid but not Medicare.\nConcepts: preserv (Laboratory Procedure)\tSSP29 (Apoptosis Promoter Gene)\tNURSING FACILITY CERTIFIED UNDER MEDICAID BUT NOT CERTIFIED UNDER MEDICARE (Health care facility)\tStreptococcus pyogenes Rosenbach 1884 (Beta-hemolytic Streptococcus, group A)\tRecurrent Follicular/Papillary Thyroid Gland Carcinoma (Recurrent Thyroid Carcinoma)", + "output": "NURSING FACILITY CERTIFIED UNDER MEDICAID BUT NOT CERTIFIED UNDER MEDICARE (Health care facility)" + }, + { + "input": "Definition: Specimen Collection described as monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the soil; includes periodic or continuous surveillance or testing to determine the level of compliance with statutory requirements and/or pollutant levels in the soil.\nConcepts: Intrauterine device (Therapeutic Device)\tsoil sampling (Specimen Collection)\tBRACKET, METAL, ORTHODONTIC (Medical Device)\tGeneral products and technology for play (Manufactured Object)\tLeft orbital region (Eye)", + "output": "soil sampling (Specimen Collection)" + }, + { + "input": "Definition: Liver described as any structural anomaly of the mitochondria.\nConcepts: Abnormal mitochondrion morphology (Finding)\tpositive regulation of actin-filament motor activity (regulation of microfilament motor activity)\tModerate Sedation (PROCEDURE NOTE)\tResult Code (Intellectual Product)\talpha-glucan anabolism (Molecular Function)", + "output": "Abnormal mitochondrion morphology (Finding)" + }, + { + "input": "Definition: Medical Device described as cardiac valve prostheses made of metals, synthetic materials or a combination of these without including any biological component. These prostheses are usually made of strong and very durable materials such as titanium and pyrolytic carbon that may be combined with synthetic materials (e.g., silicone rubber, Teflon, polypropylene); the size and configurations used depend on the type of cardiac valve to be replaced (i.e., mitral, tricuspid, aortic, or pulmonary) and the anatomic characteristics of the particular patient. Artificial cardiac valves may use several different mechanical configurations such as caged ball, tilting disk, and bileaflet.\nConcepts: internode (cellular anatomical entity)\tArtificial Cardiac Valves (Medical Device)\tSequence Arm (Intellectual Product)\tAutologous BCMA-4-1BBz-targeted CAR T-cells (Antineoplastic Immune Cell)\tIntermediate Cell Type Ciliary Body Melanoma (Neoplastic Process)", + "output": "Artificial Cardiac Valves (Medical Device)" + }, + { + "input": "Definition: Veratrum Alkaloids described as structurally-related alkaloids that contain the cevane carbon backbone.\nConcepts: Dental abutments (Medical Device)\tSpecific gravity (property) (Body fluid property)\tDisplays, mRNA Differential (Laboratory Procedure)\tIPAQ Long Last 7 Days Telephone Format Version - Walking Leisure Hours per Day (IPAQ Long Last 7 Days Telephone Format Version Questionnaire Question)\tCevane Alkaloids (Heterocyclic Compounds, 4 or More Rings)", + "output": "Cevane Alkaloids (Heterocyclic Compounds, 4 or More Rings)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents used in laboratory analysis of the cellular and humoral immune function (i.e., laboratory immunology). They can determine substances that constitute a challenge for the human body (i.e., antigens) or that are the result of the response of the body to such substances (i.e., antibodies). These reagents are used in molecular immunologic tests to characterize tissues (i.e., tissue typing), frequently to match donor and recipient in transplants.\nConcepts: TAN1 protein, human (Amino Acid, Peptide, or Protein)\tpositive regulation of NK cell cytokine production (Cell Function)\tmethylenedioxymethamphetamine (Central Nervous System Stimulants)\tLamina Rara Externa (Kidney part)\tIVD Test Reagent/Kits, Molecular Assay, Immunology (IVD Test Reagent/Kits, Molecular Assay)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Immunology (IVD Test Reagent/Kits, Molecular Assay)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Baseline (C-SSRS Baseline) Description of most severe ideation.\nConcepts: CSS01-Most Severe Ideation, Description (Intellectual Product)\tYersinia kristensenii Bercovier et al. 1981 (Bacterium)\tBacillus fluorescens putidus (Pseudomonas)\tWHODAS 2.0 36-item Version Self-administered - Understanding What People Say (WHODAS 2.0 36-item Version Self-administered Questionnaire Question)\tcalcium-dependent cysteine-type endopeptidase activity (Molecular Function)", + "output": "CSS01-Most Severe Ideation, Description (Intellectual Product)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a radioconjugate composed of a nanobody directed against human epidermal growth factor receptor 2 (HER2, EGFR2, ERBB2) that is linked, through the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68-NOTA-anti-HER2 Nanobody VHH1, the anti-HER2 antibody moiety targets and binds to HER2-expressing cells. This facilitates both detection of HER2-expressing tumor cells and assessment of responses to HER2-targeted chemotherapeutic agents during PET/CT. HER2, a tyrosine kinase is overexpressed on the cell surfaces of various tumor cell types.\nConcepts: Myasthenia gravis paralytica (Movement Disorders)\tgallium Ga 68-NOTA-anti-HER2-VHH1 (Indicator, Reagent, or Diagnostic Aid)\tAbnormal Blood Chemistry and Hematology Test Result (Laboratory test result abnormal)\tVFQ225 (VFQ25-Self Administered Format Questionnaire Question)\tIdiopathic Isolated Growth Hormone Deficiency (Finding)", + "output": "gallium Ga 68-NOTA-anti-HER2-VHH1 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as neurotic reactions to unusual, severe, or overwhelming military stress.\nConcepts: combat disorders (Mental or Behavioral Dysfunction)\trhombomere 3 structural organisation (Organ or Tissue Function)\tEstimated intake of fat and oil in 24 hours (Nutrient Intake)\tlymphoid lineage restricted progenitor cell migration into thymus involved in thymic epithelium morphogenesis (lymphoid lineage cell migration into thymus)\tRoss procedure (Therapeutic or Preventive Procedure)", + "output": "combat disorders (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Device associated with orthopaedic cements described as dispensers intended to store and inject orthopedic fluid cement into bone cavities. These dispensers are usually manually operated syringe-like devices. Orthopedic cement dispensers regularly include a transfer channel with one opening for dispensing the fluid cement and another opening through which this fluid cement exits through an applicator into a bone cavity. These dispensers may be made of plastic (e.g., acrylic), metal (e.g., stainless steel), or a combination of these. They are commonly used in orthopedic surgical procedures.\nConcepts: Small end part of finger bones (Anatomical Abnormality)\tMONITOR, TEMPERATURE, DIALYSIS (Medical Device)\tCement Dispensers, Orthopedic (Syringes)\tGL-0817 Vaccine (Immunologic Factor)\thealth mental treatment (Common nursing interventions)", + "output": "Cement Dispensers, Orthopedic (Syringes)" + }, + { + "input": "Definition: transmembrane transporter activity described as enables the transfer of lipo-chitin oligosaccharide from one side of a membrane to the other.\nConcepts: Multi-Layer Compression Bandage Systems (Pressure dressing)\tBone formation, function (Functions and Functional Disorders of Bone)\tCaecostomy (Cecotomy)\tAntigen receptor (Receptors, Cell Surface)\tlipo-chitin oligosaccharide transmembrane transporter activity (transmembrane transporter activity)", + "output": "lipo-chitin oligosaccharide transmembrane transporter activity (transmembrane transporter activity)" + }, + { + "input": "Definition: Anatomical Abnormality described as small expansion of the helical fold at the junction of the superior and descending portions of the helix.\nConcepts: suspensor development (anatomical structure development)\tUrethral Gel Dose Form (Urethral Dosage Form)\tOxidized VLDL Cholesterol (Finding)\tHelix, Darwin tubercle (Anatomical Abnormality)\tReceptors, Nuclear and Cytoplasmic (DNA-Binding Proteins)", + "output": "Helix, Darwin tubercle (Anatomical Abnormality)" + }, + { + "input": "Definition: Colony-Stimulating Factors described as granulocyte-macrophage colony-stimulating factor (144 aa, ~16 kDa) is encoded by the human CSF2 gene. This protein plays a role in the positive regulation of the growth and differentiation of cells in the granulocyte, macrophage, eosinophil and erythrocyte lineages.\nConcepts: IPAQ Short Last 7 Days Telephone Format Version - Moderate Physical Minutes per Day (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tpositive regulation of acetylcholine secretion, neurotransmission (positive regulation of response to drug)\tPhysical Carcinogens (Hazardous or Poisonous Substance)\tBAC aCGH (Molecular Biology Research Technique)\tTC-GM-CSF (Immunologic Factor)", + "output": "TC-GM-CSF (Immunologic Factor)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare autosomal dominantly inherited disease of childhood characterized by hypoproliferative anemia, hyperuricemia and slowly progressing kidney failure due to dysregulation of the renin-angiotensin system.\nConcepts: Lasers, Diode, Interstitial Thermotherapy (Medical Device)\tBRAF V600E Mutation Present (Laboratory or Test Result)\tRenin associated familial juvenile hyperuricemic nephropathy (Urate nephropathy)\tmultiple synapse bouton (Presynaptic Terminals)\tColorectal Carcinoma Metastatic in the Lung (Metastatic Colorectal Carcinoma)", + "output": "Renin associated familial juvenile hyperuricemic nephropathy (Urate nephropathy)" + }, + { + "input": "Definition: Body Location or Region described as a unipolar electrocardiogram lead site; the electrode is placed on the anterior chest wall midway between leads V2 and V4. In large and small animals, it is placed over the dorsal spinous process of the 7th thoracic vertebra.\nConcepts: Reduced NK cell number (Abnormal natural killer cell count)\tPACKING (Biomedical or Dental Material)\tstyrene catabolism (organic cyclic compound catabolic process)\tRoot Identifier (Intellectual Product)\tLead site V3 (Electrocardiograph lead site)", + "output": "Lead site V3 (Electrocardiograph lead site)" + }, + { + "input": "Definition: Structural brain disorders NEC described as traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.\nConcepts: Tissue Choppers (In Vitro Diagnostics and Laboratory Equipment)\tCraniocerebral injury (Injury or Poisoning)\tUPD1-Mentation, Behavior, Mood Sub-Total (Intellectual Product)\tCHROMOSOME 17p11.2 DELETION SYNDROME (Chronobiology Disorders)\tCTSX (CTSZ gene)", + "output": "Craniocerebral injury (Injury or Poisoning)" + }, + { + "input": "Definition: Abnormally folded helix described as a condition in which the helix is folded over to a greater degree than normal. That is, excessive curling of the helix edge, whereby the free edge is parallel to the plane of the ear.\nConcepts: CDISC ADAS-Cog - Naming Objects and Fingers: Pinky (ADAS-Cog CDISC Version Questionnaire Question)\t5p13-p12 (Cell Component)\tOverfolded helix (Ear structure)\tTissue Culture Stimulation Units, Electric Field (Manufactured Object)\tPARENT-DDS - Only One Takes Responsibility (PARENT-DDS Questionnaire Question)", + "output": "Overfolded helix (Ear structure)" + }, + { + "input": "Definition: Health Care described as the development and testing of a drug, device, or therapy in human subjects to determine safety and efficacy.\nConcepts: MAM- and EGF-Containing Gene (EGFL6 gene)\tut./adnexal mnplxn ea.mnplxn (Therapeutic or Preventive Procedure)\ttriacylglycerol metabolism (Molecular Function)\tclinical research and development (Research Activity)\tdisorder diabetes mellitus (Rheumatic illness with extraarticular and/or constitutional features (fever, rash, pleurisy,etc) OR Systemic illness with rheumatic manifestation)", + "output": "clinical research and development (Research Activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.\nConcepts: lecitholipase activity (Molecular Function)\tRegulatory Documentation Category (Document type)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification (IVD Test Reagent/Kits, Microbiology, Bacteria)\tMAP (Laboratory Procedure)\t5-(2,4-dihydroxy-5-(1-methylethyl)phenyl)-2,4-dihydro-4-(1-methyl-1h-indol-5-yl)- (HSP90 Inhibitor)", + "output": "lecitholipase activity (Molecular Function)" + }, + { + "input": "Definition: Tubule of testis described as zone of testis located at its inferior end. Examples: There is only one lower pole of testis.\nConcepts: 2-methyl-6-solanyl-1,4-benzoquinone methyltransferase activity (Molecular Function)\tRexed lamina (Body Part, Organ, or Organ Component)\tFormer Hormonal Contraceptive User (Finding)\tExtremitas inferior (Pole of testis)\tHAIRY/ENHANCER OF SPLIT, DROSOPHILA, HOMOLOG OF, 4 (Gene or Genome)", + "output": "Extremitas inferior (Pole of testis)" + }, + { + "input": "Definition: Pharmacologic Substance described as a hydrazone derivative of isoniazid, used in the treatment and prophylaxis of tuberculosis.\nConcepts: SUDOSE (Dosage)\tOrthoses, Upper Limb, Finger, Carpo-Metacarpal/Metacarpo-Phalangeal Joint, Functional (Medical Device)\tACONIAZIDE (Pharmacologic Substance)\tHHF5 (Gene or Genome)\tsn-glycerol 3-phosphate acyltransferase activity (O-acyltransferase activity)", + "output": "ACONIAZIDE (Pharmacologic Substance)" + }, + { + "input": "Definition: Pulmonary Valve Insufficiency described as a condition following an arterial switch operation to correct transposition of the great arteries, in which the old aortic root becomes the new pulmonary root and where the new pulmonary valve does not prevent backflow to the right ventricle.\nConcepts: SYSTEM, DOCUMENTATION, BREAST LESION (Medical Device)\tNeopulmonary valve regurgitation (Disease or Syndrome)\tlymphadenopathy mediastinal (Disease or Syndrome)\tundef.nrse new inofc W nrsng (New client in-office with nursing diagnosis)\tOsteoarthritis of the Hip (Musculoskeletal)", + "output": "Neopulmonary valve regurgitation (Disease or Syndrome)" + }, + { + "input": "Definition: ECG myocardial ischemia described as an electrocardiographic finding assessment of new or presumed new significant ST-segment-T wave (ST-T) changes or new left bundle branch block consistent with acute myocardial ischemia. (Thygesen K, Alpert JS, Jaffe AS, et al.: the Writing Group on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Universal Definition of Myocardial Infarction. J Am Coll Cardiol 60(16):1-18, 2012)\nConcepts: Epithelial cell signaling in Helicobacter pylori infection (Functional Concept)\tmin.mg/ml/(kg/m2) (Quantitative Concept)\tAMIEGCHG (Finding)\tDentata, Fascia (Brain part)\tbcg vaccine (Tuberculosis Vaccines)", + "output": "AMIEGCHG (Finding)" + }, + { + "input": "Definition: something described as striated muscle cell which has as its direct parts two or more peripherally located nuclei.\nConcepts: 5-dehydroshikimic reductase activity (Molecular Function)\trab1 GTP-Binding Proteins (Amino Acid, Peptide, or Protein)\tActivating CD79b Molecule Gene Mutation (CD79B Gene Mutation)\tskeletal muscle fibre (Cells)\tEarly Invasive Cervical Squamous Cell Carcinoma (Cervical Squamous Cell Carcinoma)", + "output": "skeletal muscle fibre (Cells)" + }, + { + "input": "Definition: something described as one ring heterocyclic compounds defined by C6H7NO. Permitted are any degree of hydrogenation, any substituents and any ortho-fused or ortho-peri-fused ring systems.\nConcepts: Fetal Weight (Organism Attribute)\tautologous 4H11-28z/fIL-12/EFGRt+ genetically-modified T cells (Chimeric Antigen Receptor T-cells)\tMaxillary Sinus Cancer Clinical TNM Finding v7 (Finding)\tOxazocines (Azocines)\tConsistencies (Qualitative Concept)", + "output": "Oxazocines (Azocines)" + }, + { + "input": "Definition: CCQ 1 Week Version Questionnaire Question described as clinical COPD Questionnaire 1 Week Version - In general, during the past 7 days, how much of the time: Did you produce sputum or phlegm?\nConcepts: N mRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tcrusIIp (Body Part, Organ, or Organ Component)\tIsomaltose (Organic Chemical)\tCCQ 1 Week Version - Produce Sputum or Phlegm (Intellectual Product)\tDoublecortin Domain-Containing Protein 3A (Amino Acid, Peptide, or Protein)", + "output": "CCQ 1 Week Version - Produce Sputum or Phlegm (Intellectual Product)" + }, + { + "input": "Definition: Polysomnography described as the determination of the ratio of N3 sleep time compared to total sleep time. The measurement may be expressed as a ratio or percentage.\nConcepts: N3 Sleep/Total Sleep Time (Laboratory Procedure)\tUPDRS - Symptomatic Orthostasis: Blood Pressure, Supine (UPDRS Questionnaire Question)\tBreast Cancer pT1c TNM Finding v8 (Breast Cancer pT1 TNM Finding v8)\tCorpuscular Hemoglobin Concentration Mean (Laboratory or Test Result)\tHumeral Component Trial Implants (Medical Device)", + "output": "N3 Sleep/Total Sleep Time (Laboratory Procedure)" + }, + { + "input": "Definition: Undesired Appetite Increase Scale described as a subjective score of 1 on a scale that ranges from 0: No undesired appetite increase at all to 10: Undesired appetite increase as bad as it can be.\nConcepts: Retrovirology (Virology, RNA Viruses)\tSOWS Subjective (Handelsman) - I Have Cold Flashes (Intellectual Product)\tUndesired Appetite Increase Score 1 (Intellectual Product)\tFanconi anemia complementation group E (FA Complementation Group Gene)\tHuman Research Subject Protection (Research Activity)", + "output": "Undesired Appetite Increase Score 1 (Intellectual Product)" + }, + { + "input": "Definition: Finding described as no primary identified.\nConcepts: (L/min)/(ug/m2/d) (Quantitative Concept)\tHPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pT0 TNM Finding v8 (Finding)\tcytosine arabinoside (Arabinonucleosides)\tDental Pulp Tests (Diagnostic Procedure)\tcare infertility (rnax OB/GYN actions)", + "output": "HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pT0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as the process in which an organism effects a change in the structure or function of the cell wall of a second organism, where the two organisms are in a symbiotic interaction.\nConcepts: Perifollicular Fibroma (Benign Cutaneous Fibroblastic Neoplasm)\tTrappings, Spin (Chemistry, Analytic)\tMauthner's neuron (Neurons)\tBis(2-ethylhexyl) 1,2-Benzenedicarboxylate (Epichlorohydrin)\tmodification by organism of cell wall of other organism involved in symbiotic interaction (Cell Function)", + "output": "modification by organism of cell wall of other organism involved in symbiotic interaction (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the phase in a lifecycle of a scheduled activity. EXAMPLE(S): For a lab test, this would be the condition or stage in the lifecycle of the test (e.g., \"scheduled\", \"canceled\", \"performed\"). OTHER NAME(S): NOTE(S): Please refer to the Scheduled Activity Status state transition diagram for further details.\nConcepts: Defined Material Process Step (Functional Concept)\tLEUKOSIALIN (Gene or Genome)\tHead/Chin Rests, Ophthalmic Test (Ophthalmological Equipment and Supplies)\tScheduledActivity.statusCode (Code)\tCDISC Define-XML Analysis Reason Terminology (CDISC Define-XML Terminology)", + "output": "ScheduledActivity.statusCode (Code)" + }, + { + "input": "Definition: Cervical plexus structure described as peripheral nerve, each instance of which consists of nerve fibers from some second and third cervical spinal nerves, and supplies skin over some parotid gland, mastoid process and surface of outer ear.\nConcepts: Bilateral Bulging on Pharyngeal Contraction (Finding)\tNervus auricularis magnus (Non-Autonomic Spinal Nerves)\tLAMBDA, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tmuscles neck of (Skeletal muscle structure)\tSelective attention (Attention)", + "output": "Nervus auricularis magnus (Non-Autonomic Spinal Nerves)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an enzyme that catalyzes the oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX by the conversion of two propionate groups to two vinyl groups. It is the sixth enzyme in the 8-enzyme biosynthetic pathway of HEME, and is encoded by CPO gene. Mutations of CPO gene result in HEREDITARY COPROPORPHYRIA.\nConcepts: Protection, Crop (Agriculture)\tPeriodontiums, Apical (Tissue)\tRecurrent Dedifferentiated Chordoma (Neoplastic Process)\tCoproporphyrinogenase (Red cell enzyme)\tAmerican Hairless Terrier (Mammal)", + "output": "Coproporphyrinogenase (Red cell enzyme)" + }, + { + "input": "Definition: CCR2 gene described as human CCR2 wild-type allele is located in the vicinity of 3p21.31 and is approximately 7 kb in length. This allele, which encodes C-C chemokine receptor type 2 protein, is involved in both chemokine binding and signaling.\nConcepts: HIST1H2BD (Amino Acid, Peptide, or Protein)\tCCR2 wt Allele (Gene or Genome)\tCHOREATIC DIS (Involuntary Movements)\tCHTOG (CKAP5 gene)\tForamen Magnum Meningioma (Neoplastic Process)", + "output": "CCR2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Medical Device described as air pressure units (i.e., generators) designed for treatment of excess fluid volume and pressure in the middle ear (i.e., Meniere's disease). These devices consist of a low-pressure generator that delivers low-frequency, low-amplitude pressure pulses to the middle ear through a ventilation tube that was previously implanted into the patient's eardrum, between the external canal and the middle ear. The device administers automatically controlled pulses of air to increase the pressure within the middle ear, reducing fluid pressure in the inner ear. Middle ear pressure therapy units are used to alleviate the symptoms of Meniere's disease when other clinical treatments (e.g., administration of drugs) have failed.\nConcepts: Helix, Darwin notch (Cleft helix)\tregulation of feeding behavior (regulation of behavior)\tdetection of activity (detection of stimulus)\tTrPAL (Cell)\tAir Pressure Therapy Units, Middle Ear (Electromechanical Devices)", + "output": "Air Pressure Therapy Units, Middle Ear (Electromechanical Devices)" + }, + { + "input": "Definition: something described as a measurement of the Betula pollen antigen IgG4 antibody in a biological specimen.\nConcepts: MALAN SYNDROME (Multiple malformation syndrome with early overgrowth)\tBirch Pollen IgG4 (Immunoglobulin measurement)\tMSKE (Pharmacologic Substance)\tAllopathic & Osteopathic Physicians; Pediatrics, Hospice and Palliative Medicine (Professional or Occupational Group)\tIDSR1-Feeling Anxious or Tense (IDS-SR Questionnaire Question)", + "output": "Birch Pollen IgG4 (Immunoglobulin measurement)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as represents fibers within the hypothalamus that are not readily distinguished in myelin-stained histological cross-sections ( Nomina-1983 ).\nConcepts: negative regulation of compound eye retinal cell programmed cell death (negative regulation of retinal cell programmed cell death)\tfamilial spastic paraplegia autosomal recessive type 44 (Disease or Syndrome)\tRecurrent Langerhans Cell Histiocytosis (Neoplastic Process)\tmetastatic uterine sarcoma (Neoplastic Process)\tFibrae paraventriculares (Body Part, Organ, or Organ Component)", + "output": "Fibrae paraventriculares (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Silent Mutation described as a nucleotide substitution at position 183 of the coding sequence of the NRAS gene where adenine has been mutated to guanine.\nConcepts: Sensation, Hyperalgesic (Hyperesthesia)\t2-Fluoro-1-methoxy-4-(pentafluorophenyl-sulfonamido)benzene, Sodium Salt (Organic Chemical)\televation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger (positive regulation of cytosolic calcium ion concentration)\tmcg/mL/h (Quantitative Concept)\tN-ras c.183A>G (Silent Mutation)", + "output": "N-ras c.183A>G (Silent Mutation)" + }, + { + "input": "Definition: Amyloid Proteins described as an ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.\nConcepts: Antepartum Hemorrhage, First Trimester (Pathologic Function)\tcochlea development (anatomical structure development)\tSoft Tissue Sarcoma (Childhood Soft Tissue Sarcoma)\tAmyloid Protein AA Precursor (Amyloid Proteins)\tNeobladder Reconstruction (Reconstructive Surgical Procedures)", + "output": "Amyloid Protein AA Precursor (Amyloid Proteins)" + }, + { + "input": "Definition: glutathione described as poly-glutathione peptides composed of (Glu-Cys)n-Gly where n is two to seven. They are biosynthesized by glutathione gamma-glutamylcysteinyltransferase and are found in many PLANTS; YEASTS; and algae. They sequester HEAVY METALS.\nConcepts: Did you feel left out (Clinical or Research Assessment Question)\tPosterior horn of lateral ventricle (Body Part, Organ, or Organ Component)\tIonol (Organic Chemical)\tGDS0126 (GDS Questionnaire Question)\tPhytochelatin (Pharmacologic Substance)", + "output": "Phytochelatin (Pharmacologic Substance)" + }, + { + "input": "Definition: Transient Hypogammaglobulinemia described as at birth, newborns are endowed with maternal antibodies. IgG production normally begins at the age of two months. A delay in recovery from this physiological hypogammaglobulinemia between the 3rd and the 6th month of life, and of recovery period between 18 and 36 months defines transient newborn hypogammaglobulinemia.\nConcepts: Transient hypogammaglobulinemia of infancy (Hypogammaglobulinemia)\tepoxyqueuosine reductase activity (oxidoreductase activity)\tALPLS (Alkaline phosphatase measurement)\t(3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid (Immunologic Adjuvants)\tregulation of mesenchymal cell apoptosis involved in metanephros development (regulation of mesenchymal cell apoptotic process)", + "output": "Transient hypogammaglobulinemia of infancy (Hypogammaglobulinemia)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus Species, Antigen described as serology reagents used in tests intended to detect antigens that permit the identification of strains of Streptococcus group F (e.g., Streptococcus anginosus, also known as Streptococcus milleri), spherical bacteria of the family Streptococcaceae. Group F streptococci are bacterial pathogens of humans that may cause subcutaneous or organ abscesses, endocarditis, and mild upper-respiratory-tract infections.\nConcepts: Abnormality of dorsoventral patterning of the limbs (Hand deformities)\tELECTROPHYSIOL (Physiological Phenomena)\tIntersexuality (congenital reproductive system disorder)\tIVD Test Reagent/Kits, Serology, Bacteria, Streptococcus F, Antigen (IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus Species, Antigen)\tNecrosis, Avascular, of Bone (non-articular bone disorders)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus F, Antigen (IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus Species, Antigen)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the retinoic acid induced 1 (RAI1) gene, located at chromosome 17p11.2, which encodes the protein retinoic acid-induced protein 1. Genetic variants at this locus have been associated with Smith-Magenis syndrome.\nConcepts: paired box gene 2 (Gene or Genome)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RAI1 (Medical Device)\tRecurrent abscess formation (Finding)\tDefective Thyroglobulin Transport (Thyroglobulin Deficiency)\tEVI16 (Gene or Genome)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RAI1 (Medical Device)" + }, + { + "input": "Definition: Zone of sternum described as the smallest and most inferior triangular protrusion of the STERNUM or breastbone that extends into the center of the RIBCAGE.\nConcepts: X-Ray Film Densitometers (Radiological quality assurance device)\tcalcium:cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration (calcium:cation antiporter activity)\tmesonephric nephron epithelium development (mesonephric epithelium development)\tStructure of xiphoid process of sternum (bones of rib cage)\tNRXN3 Gene Product (Cell Adhesion Molecules)", + "output": "Structure of xiphoid process of sternum (bones of rib cage)" + }, + { + "input": "Definition: Type of drug preparation described as a ointment intended for administration in or around the eye.\nConcepts: How much of the time did your caregiving responsibilities make it difficult for you to keep your mind on your work (Intellectual Product)\tMINICHROMOSOME MAINTENANCE COMPLEX COMPONENT 5 (Gene or Genome)\tpromonocyte count in blood (Laboratory Procedure)\tnasal glioma (Congenital anomaly of brain)\tOphthalmic ointment, NOS (Ointments)", + "output": "Ophthalmic ointment, NOS (Ointments)" + }, + { + "input": "Definition: Organic Chemical described as a reagent commonly used in biochemical studies as a protective agent to prevent the oxidation of SH (thiol) groups and for reducing disulphides to dithiols.\nConcepts: Speech Mirrors (Medical Device)\tCleland Reagent (Thioglycosides)\tACTH-Producing Pituitary Adenomas (Functioning pituitary neoplasm)\tCTCAE Grade 1 Myositis (Finding)\tIVD Panels, Human Genetics, Multisystem Disorder, Stickler Syndrome, Del/Dup (IVD Panels, Human Genetics, Multisystem Disorder, Stickler Syndrome)", + "output": "Cleland Reagent (Thioglycosides)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version (C-SSRS Lifetime/Recent Version) Most lethal attempt actual lethality/medical damage.\nConcepts: CSS11-Most Lethal Attempt Damage (C-SSRS Lifetime/Recent Version Questionnaire Question)\tMuscle, Skeletal Receptor Tyrosine-Protein Kinase (Receptor)\tPRESSURISED INHALATION, EMULSION (Pulmonary dose form)\tregulation of cell proliferation involved in kidney morphogenesis (regulation of cell population proliferation)\t21q22.3 (Cell Component)", + "output": "CSS11-Most Lethal Attempt Damage (C-SSRS Lifetime/Recent Version Questionnaire Question)" + }, + { + "input": "Definition: something described as a protein complex that possesses DNA methyltransferase activity.\nConcepts: Aplasia/Hypoplastia of the eccrine sweat glands (Anatomical Abnormality)\tATG1A (Serine/Threonine Protein Kinase Gene)\tDNA methyltransferase complex location (Cell Component)\tnegative regulation of cellular amine catabolic process (regulation of cellular amine catabolic process)\tEctodermal dysplasia with blindness syndrome (Eye Abnormalities)", + "output": "DNA methyltransferase complex location (Cell Component)" + }, + { + "input": "Definition: PCL-5 Questionnaire Question described as the PTSD Checklist for DSM-5 - In the past month, how much were you bothered by: Irritable behavior, angry outbursts, or acting aggressively?\nConcepts: primary amino acids (Amino Acid, Peptide, or Protein)\tStereotactic Systems, Image-Guided, Radiosurgical (Stereotactic Systems, Frame-Guided)\tPCL-5 - Irritable Behavior or Angry Outbursts (Intellectual Product)\t1-18:1-2-18:1-sn-glycerol-3-phosphocholine desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)\tDTRMWXHS-12 (Antineoplastic Enzyme Inhibitor)", + "output": "PCL-5 - Irritable Behavior or Angry Outbursts (Intellectual Product)" + }, + { + "input": "Definition: something described as a measurement of the Entamoeba histolytica DNA in a biological specimen.\nConcepts: Ash-leaf spot (Hypomelanotic macule)\tLong (DataType)\tCell Compartment Analysis (Research Techniques)\tVertebral joints set (Set of postcranial axial joints)\tEntamoeba histolytica DNA Measurement (Microbiology procedure)", + "output": "Entamoeba histolytica DNA Measurement (Microbiology procedure)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of synaptic vesicle uncoating.\nConcepts: regulation of synaptic vesicle coat protein depolymerization (Cell Function)\tcyclodextrin binding (oligosaccharide binding)\tHawaii-Aleutian Daylight Time (Temporal Concept)\tmeristem determinacy (multicellular organismal process)\tascospore wall chitin biosynthetic process (cellular amine metabolic process)", + "output": "regulation of synaptic vesicle coat protein depolymerization (Cell Function)" + }, + { + "input": "Definition: Esophageal Pain, CTCAE 5 described as mild pain\nConcepts: fevers tick (Animal Diseases)\tGrade 1 Esophageal Pain, CTCAE (Finding)\tVaginal enterocelectomy (Repair of enterocele by vaginal approach)\tPace of thought (Mental Process)\tPerformed Supply Expected Use Data Range (Temporal Concept)", + "output": "Grade 1 Esophageal Pain, CTCAE (Finding)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions or duplications of the tumor protein p53 (TP53) gene, located at chromosome 17p13.1, which encodes the protein cellular tumor antigen p53. Genetic variants at this locus have been associated with Li-Fraumeni syndrome and many types of cancers.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TP53 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tHPV-16E7(12-20) peptide vaccine (Cancer Vaccines)\tWALNUT (Structured Product Labeling Flavor)\tStage IB Soft Tissue Retroperitoneal Sarcoma AJCC v8 (Neoplastic Process)\tReview of Reported Cases (Intellectual Product)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TP53 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Anabolism described as the chemical reactions and pathways resulting in the formation of reactive oxygen species, any molecules or ions formed by the incomplete one-electron reduction of oxygen.\nConcepts: Primer, Oligodeoxyribonucleotide (Nucleic Acid, Nucleoside, or Nucleotide)\treactive oxygen species biosynthesis (Biologic Function)\tSupercomputing (Machine Activity)\textrathymic T lymphocyte selection (Cell Function)\tB.A.D. Codes (Intellectual Product)", + "output": "reactive oxygen species biosynthesis (Biologic Function)" + }, + { + "input": "Definition: Caucasians described as denotes a person from Spain or of Spanish descent.\nConcepts: Paced Ventricular Rhythm without Intrinsic Ventricular Complexes (Finding)\tNidovirales Infections (RNA Virus Infections)\tSpaniard (Population Group)\tfrontal cortex (Cerebral cortex)\ttunicamycin (Ribonucleosides)", + "output": "Spaniard (Population Group)" + }, + { + "input": "Definition: Scattering, Radiation described as the scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY).\nConcepts: Ile-Pro-Tyr-Ile-Leu (NTS Gene Product)\tMuscle tone functions (Muscle functions)\tXray Diffractions (Crystallography)\tMAGEA12 Gene (LINC01194 gene)\tFLCN wt Allele (FLCN gene)", + "output": "Xray Diffractions (Crystallography)" + }, + { + "input": "Definition: Finding described as an abnormal reduction in 4-hydroxyphenylpyruvate dioxygenase level.\nConcepts: cellular response to pH (cellular response to abiotic stimulus)\tReinjuries (Injury or Poisoning)\tReducted HPPD activity (Finding)\tVariant anatomical structure (Body Part, Organ, or Organ Component)\tBONE MARROW MEGAKARYOCYTES INCREASED (Finding)", + "output": "Reducted HPPD activity (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as traditional Chinese methods of acupuncture therapy for treating disease by inserting needles along specific pathways or meridians; acupressure uses the same pressure points as acupuncture, but is a type of massage in which finger pressure on specific body sites is used to promote healing, relieve fatigue, etc.\nConcepts: B cell homeostatic proliferation (Cell Function)\tHPCA (Biologically Active Substance)\tacupuncture/acupressure (Therapeutic procedure)\tEmbryonic Urogenital System (Other Embryologic Structure)\tEstradiol.free (Estradiol measurement)", + "output": "acupuncture/acupressure (Therapeutic procedure)" + }, + { + "input": "Definition: Orifice of vein described as the site of the opening (non-valve) at which the superior vena cava enters the right atrium.\nConcepts: hypoxanthine:oxygen oxidoreductase activity (Molecular Function)\tnegative regulation of response to pullulan (regulation of response to pullulan)\tHearing loss, sensorineural, progressive (Sensorineural Hearing Loss)\tSuperior vena cava ostium (Body Space or Junction)\tmitral valve repair transcatheter (Catheter procedure)", + "output": "Superior vena cava ostium (Body Space or Junction)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part I. Over the past 7 days, how short of breath did you get with each of these activities?: Dressing yourself without help.\nConcepts: Refractory Desmoplastic Small Round Cell Tumor (Neoplastic Process)\tPostthrombotic syndrome (Venous Insufficiency)\tcircadian sleep/wake cycle, sleep (circadian sleep/wake cycle process)\tSingle nares (Nose)\tFACIT-Dyspnea 10 Item Short Form - Part I: Dressing Without Help (Intellectual Product)", + "output": "FACIT-Dyspnea 10 Item Short Form - Part I: Dressing Without Help (Intellectual Product)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about the ability of an individual to care for themself.\nConcepts: care for myself (Intellectual Product)\tAortas, Ascending (root)\tExcessive parenteral nutrition infusion (Alteration in nutrition: more than body requirements)\tWeakness of hip flexors (Pelvic girdle weakness)\tFruit and Vegetable Juices (Food)", + "output": "care for myself (Intellectual Product)" + }, + { + "input": "Definition: Financial Support described as methods of generating, allocating, and using financial resources in healthcare systems.\nConcepts: endodermal cell fate determination (Organ or Tissue Function)\tparodontitis (Abnormality of the gingiva)\tANTISERA, BETHESDA - BALLERUP POLYVALENT, CITROBACTER SPP. (Indicator, Reagent, or Diagnostic Aid)\tAppendiceal Carcinoid TNM Finding v7 (Appendiceal Cancer TNM Finding v7)\tFinancings, Healthcare (Financial Support)", + "output": "Financings, Healthcare (Financial Support)" + }, + { + "input": "Definition: Intellectual Product described as airway Questionnaire 20 - Does your partner find your chest trouble upsetting?\nConcepts: AQ01-Partner Upset by Your Chest Trouble (Intellectual Product)\tLipid Storage Disorder Gene Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Lysosomal Storage Disease)\tLip and Oral Cavity Cancer pT0 TNM Finding v7 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v6)\t1-Propanaminium, 3-carboxy-N,N,N-trimethyl-2-((1-oxohexadecyl)oxy)-, inner salt (Carnitine ester)\tCYL-02 (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "AQ01-Partner Upset by Your Chest Trouble (Intellectual Product)" + }, + { + "input": "Definition: DRD2 Gene Mutation described as a nucleotide substitution at position 957 of the coding sequence of the DRD2 gene where cytosine has been mutated to thymine.\nConcepts: Dysfunction, Phagocyte Bactericidal (Leukocyte Disorders)\tMalignant Apocrine Skin Neoplasm (Malignant neoplasm of sweat gland)\tNM 000795.3:c.957C>T (Cell or Molecular Dysfunction)\tPQL04-Hard Tell Doctors/Nurses How Feel (Intellectual Product)\tIdiopathic fibrosing alveolitis, acute fatal form (Idiopathic Interstitial Pneumonias)", + "output": "NM 000795.3:c.957C>T (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Radioimmunoconjugates described as a radioimmunoconjugate consisting of the humanized monoclonal antibody lintuzumab conjugated to the alpha-emitting radioisotope actinium Ac 225 with potential antineoplastic activity. The monoclonal antibody moiety of actinium Ac 225 lintuzumab specifically binds to the cell surface antigen CD33 antigen, delivering a cytotoxic dose of alpha radiation to cells expressing CD33. CD33 is a cell surface antigen expressed on normal non-pluripotent hematopoietic stem cells and overexpressed on myeloid leukemia cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82414\" active clinical trials using this agent.\nConcepts: heptadec-1-ene metabolic process (Cell Function)\tActinium AC-225 lintuzumab (Pharmacologic Substance)\troot hair cell development (Cell Function)\tprotein-phosphocysteine-glucose phosphotransferase system transporter activity (protein-phosphocysteine-sugar phosphotransferase activity)\tvery long chain fatty acid omega-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "Actinium AC-225 lintuzumab (Pharmacologic Substance)" + }, + { + "input": "Definition: Organ or Tissue Function described as degradation of CORPUS LUTEUM. In the absence of pregnancy and diminishing trophic hormones, the corpus luteum undergoes luteolysis which is characterized by the involution and cessation of its endocrine function.\nConcepts: time bleeding (Blood Physiological Phenomena)\tDouble Cortex Syndrome (Central Nervous System)\tCorpus Luteum Regression (Organ or Tissue Function)\tveratrum sabadilla/cevadilla (Pharmacologic Substance)\tIMWG Minimal Response (Finding)", + "output": "Corpus Luteum Regression (Organ or Tissue Function)" + }, + { + "input": "Definition: negative regulation of chromosome organization described as any process that stops, prevents or reduces the frequency, rate or extent of DNA duplex unwinding.\nConcepts: FAC06120 (Intellectual Product)\tnegative regulation of duplex DNA melting (Genetic Function)\tFamily Piperaceae (Phylogenetic group 1)\tLEC01-Other Stressful Event: Not Apply (LEC-5 Standard Version Questionnaire Question)\tnegative regulation of leukocyte migration (negative regulation of immune system process)", + "output": "negative regulation of duplex DNA melting (Genetic Function)" + }, + { + "input": "Definition: Contrast-enhanced Magnetic Resonance Imaging described as a modification of contrast-enhanced MRI that allows observation of functional properties in addition to structural properties.\nConcepts: MBP (Protein or Enzyme Type Measurement)\tProprioceptive Hallucination (Hallucinations)\tDCE-MRI (Diagnostic Procedure)\t3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity (Molecular Function)\tEpithelial Predominant Kidney Nephroblastoma (Nephroblastoma)", + "output": "DCE-MRI (Diagnostic Procedure)" + }, + { + "input": "Definition: Disease or Syndrome described as the surface remains intact with visible change, loss of mineral, localized demineralization where there is no observable localized breakdown or distinct cavity (hole).\nConcepts: Dark skin tone (Intellectual Product)\tWall of left ventricular inflow tract (Subdivision of wall of left ventricle)\tNon-cavitated caries (Disease or Syndrome)\tcyanophore cell differentiation (Cell Function)\tMGCN (Corneal deformity)", + "output": "Non-cavitated caries (Disease or Syndrome)" + }, + { + "input": "Definition: Volvocaceae described as a genus of GREEN ALGAE in the family Volvocaceae. They form spherical colonies of hundreds or thousands of bi-flagellated cells in a semi-transparent gelatinous ball.\nConcepts: Affected (General Qualifier)\tisopeptide cross-linking (Molecular Function)\tpositive regulation of cilium assembly (positive regulation of plasma membrane bounded cell projection assembly)\tVolvox (Plant)\tMei2 nuclear dot complex (Cell Component)", + "output": "Volvox (Plant)" + }, + { + "input": "Definition: something described as serology reagents intended to detect immunoglobulin A (IgA) antibodies to Toxoplasma gondii, a species of obligate intracellular coccidian protozoon parasite. These parasites cause toxoplasmosis, an acute or chronic disease transmitted by the feces of cats or via tissue cysts in infected meat. Most infections are mild and self-limited, but extensive damage (e.g., to the brain, eyes, cardiac muscle) may occur, especially in immunocompromised patients or in fetuses infected by transplacental transmission.\nConcepts: Gastric artery (Body Part, Organ, or Organ Component)\tinferior frontal gyrus, orbital part (Body Part, Organ, or Organ Component)\tsemaphorin-plexin signalling pathway involved in axon guidance (Molecular Function)\tregulation of behavioural fear response (regulation of fear response)\tIVD Test Reagent/Kits, Serology, Parasite, Toxoplasma gondii, IgA Antibody (Medical Device)", + "output": "IVD Test Reagent/Kits, Serology, Parasite, Toxoplasma gondii, IgA Antibody (Medical Device)" + }, + { + "input": "Definition: Behavioral/psychiatric manifestations described as false personal beliefs held contrary to reality, despite contradictory evidence and common sense.\nConcepts: fixed beliefs contradicted by reality (Behavioral/psychiatric manifestations)\tWestern Luba (Language)\tClinical Cooperative Groups (Professional Organization or Group)\tPrimary Cutaneous Peripheral T-Cell Lymphoma, Rare Subtype (Lymphoma, T-Cell, Cutaneous)\tIodopanoic acid (Iodinated contrast media)", + "output": "fixed beliefs contradicted by reality (Behavioral/psychiatric manifestations)" + }, + { + "input": "Definition: Severity Code described as a coded value specifying the intensity of the condition. EXAMPLE(S): Moderate could be used to describe acne. Values of: none,mild or trivial,moderate or severe,valve replacement,unknown could be used for a aorta valvular insufficiency OTHER NAME(S): NOTE(S): Derived from PerformedClinicalInterpretation.value(ANY=>CD) WHERE PerformedClinicalInterpretation > PerformedObservation [severity assessment] > DefinedObservation.nameCode = \"assess severity\" AND PerformedObservation [severity assessment] > AssessedResultRelationship > PerformedMedicalConditionResult\nConcepts: Performed Medical Condition Result Severity Code (Intellectual Product)\tHigh ethanolamine levels in the blood (Abnormal circulating ethanolamine concentration)\tAlpelisib-Fulvestrant Regimen (Therapeutic or Preventive Procedure)\tPenile Squamous Cell Carcinoma Clinical TNM Finding v8 (Penile Cancer TNM Finding v8)\tStudy Name (Name)", + "output": "Performed Medical Condition Result Severity Code (Intellectual Product)" + }, + { + "input": "Definition: Conceptual Entity described as able to concisely explain of the meaning of a word or phrase or symbol.\nConcepts: Definable (Conceptual Entity)\tdehiscence of surgical wound (Postoperative Complications)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug (IVD Test Reagent/Kits, Immunoassay)\tIodine supplement therapy (Health Care Activity)\tdown-regulation of apolipoprotein A-I-mediated signaling pathway (regulation of apolipoprotein A-I-mediated signaling pathway)", + "output": "Definable (Conceptual Entity)" + }, + { + "input": "Definition: something described as the presence of bacteria in the blood caused by an infected hemodialysis catheter.\nConcepts: Hemodialysis Catheter-Associated Bacteremia (Disease or Syndrome)\tPerformed Patient Note Title (Title)\tChoroid Plexus Epithelium (Epithelium)\tRisk for urge urinary incontinence (Urination)\tChemical Warfare Agents (Weapons)", + "output": "Hemodialysis Catheter-Associated Bacteremia (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as picture archiving and communication systems (PACS) workstation management software designed to operate, control/monitor a limited number of their functions, and/or process data and high-resolution volumetric digital images obtained during imaging procedures, typically providing three-dimensional (3-D) images and segmentation of the images obtained during imaging procedure. This software usually interacts with devices used in the procedure, such as diagnostic imaging systems (e.g., computed tomography, magnetic resonance imaging, and ultrasound scanning systems) as well as with recorders with very high image quality and archiving capabilities. The software may also perform a variety of algorithms to facilitate the operation and analysis of the images obtained during the procedures. Three dimensional PACS workstation software is intended to work only with one or a few models of PACS workstations and related devices, usually supplied by the same manufacturer. This facilitates the processing and/or sending data from the workstation to and from other hospital information systems. The software is not usually available separate from the workstation but may be updated (i.e., through the release of modified versions) during the life of the equipment.\nConcepts: detection of mechanical stimulus involved in sensory perception of gravity (detection of gravity)\tBCGitis (Disease or Syndrome)\tSoftware, Workstation Management, Picture Archiving and Communication System, Three-Dimensional Image (Software, Workstation Management, Picture Archiving and Communication System)\tBlades, Manual Hair Clipper (Blades)\tPaneth Cell-Like Change (Physical shape)", + "output": "Software, Workstation Management, Picture Archiving and Communication System, Three-Dimensional Image (Software, Workstation Management, Picture Archiving and Communication System)" + }, + { + "input": "Definition: Cell Culture described as a type of culture in which cells, or aggregates of cells, multiply while suspended in liquid medium.\nConcepts: Agencies; Supports Brokerage (Health Care Related Organization)\tInhibitory Self-Control Index (Research or Clinical Assessment Tool)\tProtein BTG1 (Cell Cycle Proteins)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PCCA (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tSuspension Culture (Laboratory Procedure)", + "output": "Suspension Culture (Laboratory Procedure)" + }, + { + "input": "Definition: Idea or Concept described as US military intervention in IRAQ from September 2010 to December 2011.\nConcepts: catalytic complex location (Cell Component)\tFAC084-Part I: Walk for 1/2 Mile Why Not (Intellectual Product)\tcardiac septum cell differentiation (Cell Function)\tOperation New Dawns (Idea or Concept)\tFACT-L Version 4 - Get Emotional Support From Family (Intellectual Product)", + "output": "Operation New Dawns (Idea or Concept)" + }, + { + "input": "Definition: Professional Practice described as practice of sending a patient to another program or practitioner for services or advice which the referring person is not prepared to provide; requesting advice from another person in the field.\nConcepts: CCND3 (Cyclins)\tNutritional Anthropometry (Nutritional Study)\treferral / consultation (patient care)\tTopical Solution/Cream/Gels (Biomedical or Dental Material)\tependymoma; myxopapillary (Ependymoma)", + "output": "referral / consultation (patient care)" + }, + { + "input": "Definition: Chief complaint described as occurs on average once per day.\nConcepts: Child and Youth Resilience Measure (Intellectual Product)\tEvent Experiences (Thesaurus of Psychological Index Terms)\tDaily (Finding)\tTuberculosis of adrenal glands (Inflammation of specific body systems)\tBupropion Hydrochloride Controlled-release (Pharmacologic Substance)", + "output": "Daily (Finding)" + }, + { + "input": "Definition: something described as the determination of the amount of diazepam present in a sample.\nConcepts: Whole Cell Vaccine (Pharmacologic Substance)\tClinical Observations Elapsed Time (Elapsed Time)\tHigh N/C ratio of renal tubular epithelial cells (Abnormal renal tubular epithelial morphology)\tdiazepam level test (SPECIFIC DRUG AND TOXICOLOGY TESTS)\tStage IIIB Colon Cancer AJCC v7 (Stage III Colon Cancer AJCC v7)", + "output": "diazepam level test (SPECIFIC DRUG AND TOXICOLOGY TESTS)" + }, + { + "input": "Definition: Narcotics described as an opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically. As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV.\nConcepts: Papaverine-containing product (Vasodilator Agents)\tKIAA1549-BRAF Fusion Protein (Fusion protein)\tAMF Receptor (Receptors, Cell Surface)\tPersonal hygiene (Comfortable death status)\tCYP1A2, g.558C>A (Gene or Genome)", + "output": "Papaverine-containing product (Vasodilator Agents)" + }, + { + "input": "Definition: Stage IV Pharynx Carcinoma described as stage IV nasopharyngeal cancer is divided into stages IVA, IVB, and IVC. In stage IVA, cancer has spread beyond the nasopharynx and may have spread to the cranial nerves, the hypopharynx (bottom part of the throat), areas in and around the side of the skull or jawbone, and/or the bone around the eye. Cancer may have spread to one or more lymph nodes on one or both sides of the neck and/or to lymph nodes behind the pharynx, and the affected lymph nodes are 6 centimeters or smaller. In stage IVB, cancer has spread to lymph nodes between the collarbone and the top of the shoulder and/or the affected lymph nodes are larger than 6 centimeters. In stage IVC, cancer has spread beyond nearby lymph nodes to other parts of the body.\nConcepts: Refeeding syndrome (Malnutrition)\tup regulation of androst-4-ene-3,17-dione anabolism (positive regulation of hormone biosynthetic process)\tVeiled cell (Cell)\tStage IV Nasopharynx Carcinoma AJCC v6 (Nasopharyngeal Carcinoma by AJCC v6 Stage)\tNo Flow (Finding)", + "output": "Stage IV Nasopharynx Carcinoma AJCC v6 (Nasopharyngeal Carcinoma by AJCC v6 Stage)" + }, + { + "input": "Definition: Trypanosoma brucei brucei described as hemoflagellate species of parasitic protozoa that cause nagana in domestic and game animals; transmitted by Glossina.\nConcepts: True Paroxysmal Atrial Tachycardia (Atrial tachycardia)\tFF-21101(90Y) (Pharmacologic Substance)\tAmyloid A (Laboratory Procedure)\tTrypanosoma bruceus (Blood and tissue flagellate)\tamyloplast starch grain (Cell Component)", + "output": "Trypanosoma bruceus (Blood and tissue flagellate)" + }, + { + "input": "Definition: Clinical infection described as malaria without parasitological confirmation.\nConcepts: metatarsals (Structure of short bone)\tDesulfocurvibacter africanus (Campbell et al. 1966) Spring et al. 2019 (Bacterium)\taur therp ea.15 min (Therapeutic or Preventive Procedure)\tClinical malaria (Malaria)\tductal carcinoma breast (Neoplastic Process)", + "output": "Clinical malaria (Malaria)" + }, + { + "input": "Definition: Machine Activity described as failure of equipment to perform to standard. The failure may be due to defects or improper use.\nConcepts: response to thiamin (response to vitamin)\tEquipment Failures (Investigative Techniques)\thydroxyindoleacetate (Biologically Active Substance)\tENTEROBACTER CLOACAE (Enterobacter)\tThymic Typical Carcinoid Tumor (Thymic Carcinoid Tumor)", + "output": "Equipment Failures (Investigative Techniques)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as two muscles, the serratus posterior superior and serratus posterior inferior, located in between the deep and the superficial back muscle layers. Their function is to control THORAX movement.\nConcepts: terpenoid transport (isoprenoid transport)\tTelecommunication Address Usage Type (Functional Concept)\tFetal Liver Kinase-2 F691L (Cell or Molecular Dysfunction)\tCarcinomas, Bronchial (Carcinoma of lung)\tIntermediate Back Muscle (Body Part, Organ, or Organ Component)", + "output": "Intermediate Back Muscle (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Individual Behavior described as any process that modulates the frequency, rate or extent of foraging behavior.\nConcepts: 2,4-toluenediamine (Toluenediamine)\tStage 0 AIDS-Related Anal Canal Cancer AJCC v6 and v7 (AIDS-Related Anal Canal Carcinoma)\tAbnormality of olfactory lobe morphology (Abnormality of forebrain morphology)\tventilation lung (Respiratory Therapy)\tregulation of foraging behavior (Individual Behavior)", + "output": "regulation of foraging behavior (Individual Behavior)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant B-cell lymphoproliferative process affecting the blood, bone marrow, and spleen. The B-prolymphocytes are medium-sized, round lymphoid cells with prominent nucleoli. The B-prolymphocytes must exceed 55% of lymphoid cells in the blood. Cases of transformed chronic lymphocytic leukemia (CLL) and CLL with increased prolymphocytes are excluded. The prognosis is poor.\nConcepts: StorageEquipment.dimensionTwoCapacity (Dimension Two Capacity)\tBroad proximal phalanx of toe (Anatomical Abnormality)\tL-methionine:2-oxoglutarate aminotransferase activity (methionine-oxo-acid transaminase activity)\tB Cell Prolymphocytic Leukemia (Mature B-Cell Neoplasm)\tKNI-272 (Amino Acid, Peptide, or Protein)", + "output": "B Cell Prolymphocytic Leukemia (Mature B-Cell Neoplasm)" + }, + { + "input": "Definition: Abnormality of skeletal morphology described as an autosomal recessive inherited disorder of mucopolysaccharide metabolism. It is the most severe form of mucopolysaccharidosis type I. It is characterized by deficiency of the enzyme alpha-L-iduronidase resulting in the accumulation of mucopolysaccharides in the tissues. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61261\" active clinical trials using this agent.\nConcepts: Alethinophidias (Snakes)\tHurler's Disease (Skeletal)\tLeft Ventricular Outflow Tract Velocity Time Integral (Cardiovascular finding)\tIL-5Ralpha, human (Amino Acid, Peptide, or Protein)\tTenosuspension (Therapeutic or Preventive Procedure)", + "output": "Hurler's Disease (Skeletal)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Total number of aborted.\nConcepts: oxaprozin (Propionates)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Rheumatism, Circulating Immune Complex (Medical Device)\tRibosome Subunits (Cell Component)\tC-SSRS Children's Baseline/Screening - Number of Aborted Suicide Attempts (Intellectual Product)\tchromosome 17q deletion syndrome (Disease or Syndrome)", + "output": "C-SSRS Children's Baseline/Screening - Number of Aborted Suicide Attempts (Intellectual Product)" + }, + { + "input": "Definition: Connective and Soft Tissue Neoplasm described as a rare sarcoma that arises from the vagina. This category includes low grade endometrioid stromal sarcoma and undifferentiated vaginal sarcoma.\nConcepts: Endometrioid Stromal Sarcoma of the Vagina (Neoplastic Process)\tStage III Differentiated Thyroid Gland Carcinoma AJCC v8 (Neoplastic Process)\tIncreased proportion of plasmablasts (Finding)\tKetones present in urine (LABORATORY ABNORMALITIES)\tHoldemania Willems et al. 1997 (Bacterium)", + "output": "Endometrioid Stromal Sarcoma of the Vagina (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI (ADCS-ADL MCI) If yes, did subject usually talk about what he or she read 1-24 hours after reading?\nConcepts: Recurrent Parotid Gland Squamous Cell Carcinoma (Squamous cell carcinoma of the parotid gland)\tZinc Finger SWIM-Type Containing 4 (Binding Proteins)\tPhosphatidate (Organic Chemical)\tADCS-ADL MCI - Talk Within 24 Hours After Reading (Intellectual Product)\tBarrier (Device Component or Accessory)", + "output": "ADCS-ADL MCI - Talk Within 24 Hours After Reading (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis.\nConcepts: Plutonium (Plutonium and plutonium compound)\t5-chloro-2-hydroxybenzoxazole (Muscle Relaxant [EPC])\tTea, Medicinal (Food)\tpositive regulation of cell proliferation involved in compound eye morphogenesis (Cell Function)\tSWASB (ECG Measurement)", + "output": "positive regulation of cell proliferation involved in compound eye morphogenesis (Cell Function)" + }, + { + "input": "Definition: Antioxidants described as a nanoparticle formulation containing the poorly water-soluble naturally-occurring flavonoid luteolin encapsulated within a water-soluble polymer, with potential anti-oxidant, anti-inflammatory, apoptosis-inducing and chemopreventive activities. Upon administration of the polymer-encapsulated luteolin nanoparticle, luteolin scavenges free radicals, protects cells from reactive oxygen species (ROS)-induced damage and induces direct tumor cell cycle arrest and apoptosis in tumor cells. This inhibits tumor cell proliferation and suppresses metastasis. Compared to luteolin alone, encapsulation increases the delivery of luteolin to the tumor cells by protecting the drug against clearance and degradation, increases blood circulation time and enhances delivery into the tumor through the leaky vasculature.\nConcepts: sorocarp morphogenesis (Organism Function)\tregulation of CD8-positive, alpha-beta T cell extravasation (Cell Function)\tnano-luteolin (Organic Chemical)\tregulation of anterograde synaptic vesicle transport (regulation of synaptic vesicle transport)\theme formation (pigment biosynthetic process)", + "output": "nano-luteolin (Organic Chemical)" + }, + { + "input": "Definition: Statistical Theory & Experimentation described as a statistical approach in psychological measurement in which observed scores consist of both the true score and error.\nConcepts: RITS complex assembly (ribonucleoprotein complex assembly)\tcaucasian (Race - finding)\ttear secretion (Cell Function)\tClassical Test Theory (Theory)\tdevelopmental process involved in reproduction (Reproductive process)", + "output": "Classical Test Theory (Theory)" + }, + { + "input": "Definition: Mental Process described as type of declarative memory, consisting of personal memory in contrast to general knowledge.\nConcepts: autobiographical memory (Mental Process)\tfistula bladder (Lesion of bladder)\tAKNA (Biologically Active Substance)\tGlutaredoxin1 Gene (GLRX gene)\tDipeptidyl peptidase IV inhibitor (Hypoglycemic Agents)", + "output": "autobiographical memory (Mental Process)" + }, + { + "input": "Definition: Antibiotic described as a broad-spectrum, fourth-generation cephalosporin with antibacterial activity. Cefetecol binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.\nConcepts: Invasive encapsulated follicular variant of papillary thyroid carcinoma (Follicular Variant Thyroid Gland Papillary Carcinoma)\tCEFETECOL (Antibiotic)\tneural crest cell fate specification (stem cell fate specification)\tcontractile ring localization involved in cell cycle cytokinesis (Cell Function)\tBiological Process Has Initiator Chemical Or Drug (Idea or Concept)", + "output": "CEFETECOL (Antibiotic)" + }, + { + "input": "Definition: Acute Promyelocytic Leukemia described as an acute promyelocytic leukemia occurring in children. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7968\" active clinical trials using this agent.\nConcepts: pyoverdine metabolic process (siderophore metabolic process)\tAPL, childhood (Childhood Acute Myeloid Leukemia)\tVaginal cuff (Body part)\tStage IA3 Lung Cancer (Stage IA Lung Non-Small Cell Carcinoma AJCC v7)\tCSPG6 (Biologically Active Substance)", + "output": "APL, childhood (Childhood Acute Myeloid Leukemia)" + }, + { + "input": "Definition: Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Head & Neck Symptom Index-22 Version 2 (NCCN-FACT FHNSI-22 Version 2) I am content with the quality of my life right now.\nConcepts: ISUP GLEASON GRADE GROUP (Disease Grade Qualifier)\tCD-RAP (MIA gene)\tHeart and cardiac apex malposition (Congenital heart disease)\tMaximum Atrial Rate by Electrocardiogram (Quantitative Concept)\tFAC03622 (Intellectual Product)", + "output": "FAC03622 (Intellectual Product)" + }, + { + "input": "Definition: Other epilepsy and recurrent seizures described as a childhood-onset epilepsy syndrome.\nConcepts: Device Discarded (Functional Concept)\tLennox Gastaut syndrome (Epilepsy)\tbaroreceptor response to decreased systemic arterial blood pressure (positive regulation of systemic arterial blood pressure)\tRenal interstitial granulomas (Abnormal renal insterstitial morphology)\tNik-Related Protein Kinase (Protein-Serine-Threonine Kinases)", + "output": "Lennox Gastaut syndrome (Epilepsy)" + }, + { + "input": "Definition: regulation of heme biosynthetic process described as any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of heme.\nConcepts: Short distal phalanx of the 4th finger (Short 4th finger)\tSmall Cell Adenocarcinoma (Neoplastic Process)\tCME - cystoid macular oedema (Eye and ear procedural complications)\tpigment catabolism (Molecular Function)\tnegative regulation of haem biosynthetic process (negative regulation of cofactor metabolic process)", + "output": "negative regulation of haem biosynthetic process (negative regulation of cofactor metabolic process)" + }, + { + "input": "Definition: something described as chemotherapy using a pharmacologic agent that does not directly kill cells.\nConcepts: Over The Counter Product Indicator (Indicator)\tclindamycin/hydrocortisone lotion (Chemotherapeutic Topical Agent)\tFRAT1 (Signaling Pathway Gene)\tstructural constituent of ascospore wall (structural constituent of cell wall)\tNon-Cytotoxic Drug Therapy (Chemotherapy)", + "output": "Non-Cytotoxic Drug Therapy (Chemotherapy)" + }, + { + "input": "Definition: Regimen Used to Treat Malignant Head and Neck Neoplasm described as a regimen consisting of cisplatin, fluorouracil (5-FU) and pembrolizumab that may be used in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) and advanced gastric cancer.\nConcepts: Cisplatin-Fluorouracil-Pembrolizumab (Therapeutic or Preventive Procedure)\tPapillary Eccrine Carcinoma (Neoplastic Process)\tSEMINAL VESICLES (Male genital duct)\tmesonephric glomerular mesangial cell differentiation (glomerular mesangial cell differentiation)\tHeterophyes heterophyes infection (Other fluke infections)", + "output": "Cisplatin-Fluorouracil-Pembrolizumab (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: area 9 described as the more rostral of two parts of dorsomedial prefrontal cortex located on the medial surface of the superior frontal gyrus in the human ( Bzdok-2012 ) and the macaque ( Petrides-2009 ). The other is area 8BM, which lies caudoventral to it. It is bounded dorsolaterally by area 9p and area 9a of dorsolateral prefrontal cortex, rostrally by area 10d of polar frontal cortex, and posteriorly by area d32 and area a24 of anterior cingulate cortex. Defined in the human by multiple criteria, it is fMRI-activated in a THEORY OF MIND task. It is deactivated in a RELATIONAL task, and activated or deactivated in a LANGUAGE task depending on the task with which it is compared. Other authors have referred to an overlapping part of another structure in the same topological area as 9 ( Glasser-2016 ).\nConcepts: AICARDI-GOUTIERES SYNDROME 2 (Disease or Syndrome)\tBenign Cutaneous Fibrohistiocytic Neoplasm (Neoplastic Process)\tPerformed Product Problem Discovery (Performed Clinical Study Activity)\tantiemetic (Pharmaceutical Preparations)\tarea 9M (area 9)", + "output": "area 9M (area 9)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as education of male and female students at the same institution.\nConcepts: Concentration Camp (Non-Medical Public and Private Facilities)\tCoeducation (Thesaurus of Psychological Index Terms)\tImage Digitizers, Radiographic (Digitizers)\tTOBACCO SMOKING (Drug usage)\tAlkotinib (Organic Chemical)", + "output": "Coeducation (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Parasite infestation described as a parasitic infection caused by larvae of worms of the genus Trichinella. It is transmitted to humans by ingesting raw or undercooked meat from infected animals. Signs and symptoms include abdominal discomfort, nausea, vomiting, fever, diarrhea, headache, coughing, myalgias, arthralgias, and eye swelling.\nConcepts: HOSP DENT STAFFS (Personnel, Hospital)\tDisorders, Binge-Eating (Binge eating disorder)\tILNR-Intralobar nephrogenic rest (Nephrogenic rest)\tmyristic acid (Fatty Acids)\tInfection by larvae of Trichinella (Infection caused by Trichinella)", + "output": "Infection by larvae of Trichinella (Infection caused by Trichinella)" + }, + { + "input": "Definition: Medical Device described as a compensated thorpe tube flowmeter is a device intended for medical purposes that is used to control and measure gas flow rate accurately. The device includes a vertically mounted tube, with the outlet of the flowmeter calibrated to a reference pressure.\nConcepts: uredinium development (Biologic Function)\tFLOWMETER, TUBE, THROPE, BACK-PRESSURE COMPENSATED (Medical Device)\tPerformedProtocolDeviation (Performed Clinical Study Activity)\tB-Cell Primary Central Nervous System Non-Hodgkin Lymphoma (B-Cell Lymphomas)\tRIU (Fluorescence Intensity Unit)", + "output": "FLOWMETER, TUBE, THROPE, BACK-PRESSURE COMPENSATED (Medical Device)" + }, + { + "input": "Definition: something described as regional lymph nodes cannot be assessed.\nConcepts: Undifferentiated Abdominal Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma)\tdown regulation of glucocorticoid catabolic process (Molecular Function)\tStage I Nasal Cavity Carcinoma (Neoplastic Process)\tEF-5 (Hydrocarbons, Halogenated)\tAdrenal Cortical Carcinoma pNX TNM Finding v8 (Adrenal Cortical Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Adrenal Cortical Carcinoma pNX TNM Finding v8 (Adrenal Cortical Carcinoma Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: something described as a very rare, well circumscribed, benign cystic neoplasm that arises from the lung. It is characterized by the presence of cysts which are lined by tall mucinous epithelium and filled with mucin.\nConcepts: phosphoglycolate phosphatase activity (Molecular Function)\tLung Mucinous Cystadenoma (Cystadenoma, Mucinous)\tIntegumentary system, NOS (Finnish translations of the Medical Subject Headings)\tTubes, Tracheal, Laser-Resistant (Tracheal tube)\tXR Patch (Patch Dosage Form)", + "output": "Lung Mucinous Cystadenoma (Cystadenoma, Mucinous)" + }, + { + "input": "Definition: something described as this gene is involved in the repression of neuronal gene expression.\nConcepts: olfactory receptor activity (Molecular Function)\tRE1-silencing transcription factor (Gene or Genome)\tNutrition, Vitamin B (Research Activity)\tFrameless Stereotaxy (Diagnostic Procedure)\tNeoplastic Plasma Cells Less than or Equal to 20 Percent of Bone Marrow Nucleated Cells (Finding)", + "output": "RE1-silencing transcription factor (Gene or Genome)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as a sequence of single-stranded RNA which is typically 20-25 nucleotides in length and may regulate the expression of other genes. miRNAs are transcribed from DNA, but are not translated into proteins.\nConcepts: 12 Lead Placement Standard Extended Right (Lead Placement)\tMixed Somatotroph-Lactotroph Adenoma (Somatotroph/Lactotroph Adenoma)\tzinc ion homeostasis (transition metal ion homeostasis)\tmiRNAs (Biologically Active Substance)\tComprehensive new out-of-office 60 minutes midwifery intake (Health Care Activity)", + "output": "miRNAs (Biologically Active Substance)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects.\nConcepts: propanediol transmembrane transporter activity (Molecular Function)\tAntepartum Obstetric Septic Embolism (Disease or Syndrome)\tVaginal Endometrioid Adenocarcinoma (Vaginal adenocarcinoma)\tLEC-5 Standard Version - Natural Disaster: Learned (LEC-5 Standard Version Questionnaire Question)\tGrade 4 Urine Output Decreased, CTCAE (Urine Output Decreased, CTCAE)", + "output": "propanediol transmembrane transporter activity (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as a 10-item questionnaire, derived from the Hearing Handicap Inventory for the Elderly, developed to assess how adult individuals under 65 perceive the social and emotional effects of hearing loss.\nConcepts: triangular area of Wernicke (Body Location or Region)\tOrienting Responses (Response process)\tNucleic acid amplification test (Molecular biology identification technique)\tHearing Handicap Inventory for Adults, Screening Version (Intellectual Product)\tOphthalmic examination and evaluation (ophthalmological services examination)", + "output": "Hearing Handicap Inventory for Adults, Screening Version (Intellectual Product)" + }, + { + "input": "Definition: something described as cytoplasmic, virus-induced double-membrane structures, derived from ENDOPLASMIC RETICULUM or GOLGI APPARATUS, that house the replication and transcription enzyme complexes of NIDOVIRALES and PICORNAVIRIDAE.\nConcepts: ReferenceResult.referenceTypeCode (Reference Type Code)\tAldehyde ferredoxin oxidoreductase activity (Molecular Function)\tVirus-Induced Double-Membrane Vesicle (Cell Component)\tantifolate (Microbicides)\tAxillary Lymph Node Level I (Upper limb lymph node structure)", + "output": "Virus-Induced Double-Membrane Vesicle (Cell Component)" + }, + { + "input": "Definition: Study Day described as the study day that a tumor results assessment is performed.\nConcepts: TRDY (Temporal Concept)\tTransmission, Perinatal Infection (Pathologic Function)\tnutrition therapies (nutrition and hydration services)\tDefect speech (Special Education)\tCP (Cerebral Palsy)", + "output": "TRDY (Temporal Concept)" + }, + { + "input": "Definition: Intellectual Product described as the set of terms that have been mapped to the Morphology terms with equivalent meaning in ICD-O-3.2.\nConcepts: Other Service Providers; \"Sleep Specialist, PhD\" (Professional or Occupational Group)\tSeoul (South Korea)\tCryobiology (biology)\tHypnoanesthesia (Anesthesia procedures)\tMapped ICD-O-3.2 Morphology Terminology (Mapped ICD-O-3.2 Terminology)", + "output": "Mapped ICD-O-3.2 Morphology Terminology (Mapped ICD-O-3.2 Terminology)" + }, + { + "input": "Definition: something described as microbiology reagents intended to identify group B Streptococcus species (e.g., Streptococcus agalactiae). Group B streptococci are associated with serious neonatal infections characterized by sepsis and meningitis, as well as with postpartum infections.\nConcepts: Writing (literary arts)\tCarbon C 13 Lycopene (Tracer)\tVITREORETINAL DEGENERATION, SNOWFLAKE TYPE (Disease or Syndrome)\tEPDS Questionnaire Question (Clinical or Research Assessment Question)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Streptococcus, Group B (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Streptococcus Species)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Streptococcus, Group B (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Streptococcus Species)" + }, + { + "input": "Definition: Ovarian Cancer TNM Finding v6 described as a clinical finding about one or more characteristics of ovarian cancer, following the rules of the TNM AJCC v6 classification system. TNM clinical findings are based on information obtained prior to the first definitive treatment through physical examination, diagnostic imaging, biopsy or laboratory testing.\nConcepts: Serum VLDL Cholesterol Measurement (Lipids measurement)\tlymphoma, stage III adult Hodgkin's (Adult Hodgkin Lymphoma by Ann Arbor Stage)\tOvarian Cancer Clinical TNM Finding v6 (Finding)\tpropiomazine HCl (Histamine H1 Antagonists)\tHaemolysis, NOS (Blood Physiological Phenomena)", + "output": "Ovarian Cancer Clinical TNM Finding v6 (Finding)" + }, + { + "input": "Definition: regulation of cholesterol transport described as any process that modulates the rate, frequency or extent of cholesterol import. Cholesterol import is the directed movement of cholesterol into a cell or organelle.\nConcepts: PedsQL Neuromuscular Module Version 3.0 Parent Report for Child - Take Long Time to Eat (Intellectual Product)\tregulation of cholesterol import (regulation of sterol import)\tNuclear Receptor Subfamily 3 (Receptor)\tCOPI coating of Golgi vesicle, cis-Golgi to rough ER (COPI coating of Golgi vesicle)\tEPIC112 (Intellectual Product)", + "output": "regulation of cholesterol import (regulation of sterol import)" + }, + { + "input": "Definition: Pharmacologic Substance described as compounds and drugs that bind to and inhibit or block the activation of DOPAMINE D2 RECEPTORS.\nConcepts: RDIORESP (Disease Response)\tRoman Catholic, follower of religion (Population Group)\tEGFR T790M inhibitor BPI-15086 (Epidermal growth factor receptor inhibitor)\tpmol/mmol (Molality Unit)\tDopamine D2 Antagonist (Dopamine Antagonists)", + "output": "Dopamine D2 Antagonist (Dopamine Antagonists)" + }, + { + "input": "Definition: something described as a question about why a form or questionnaire was not completed.\nConcepts: HIP (Gene or Genome)\tImpairment of Bolus Preparation or Mastication (Oral Impairment During Swallowing)\tcharged-tRNA amino acid modification (cellular protein modification process)\tReason parent did not complete (Intellectual Product)\tAttention Problems (Intellectual Product)", + "output": "Reason parent did not complete (Intellectual Product)" + }, + { + "input": "Definition: GPCR Signaling Pathway described as a series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.\nConcepts: pollen germ-cell nucleus (Cell Nucleus)\tformat (Property or Attribute)\tNerve Injury, Olfactory (Lesion of brain)\tNORMEEXR (Urine Chemistry Measurement)\tcomplement component C5a-induced signaling pathway (GPCR Signaling Pathway)", + "output": "complement component C5a-induced signaling pathway (GPCR Signaling Pathway)" + }, + { + "input": "Definition: Finding described as symptomatic; evident on physical exam; limiting instrumental ADL\nConcepts: Weed Mix Pollen IgG AB RAST Score (Laboratory Procedure)\tChronic Lymphocytic Leukemia- Binet Staging System (Chronic Lymphocytic Leukemia)\tCellular Fibroma (Fibromatous neoplasm of borderline malignancy)\tINCOMPLETE MEASUREMENTS DUE TO TRUNCATION OF QRS COMPLEXES (ECG Recording Quality)\tGrade 2 Muscle Weakness Left-Sided, CTCAE (Finding)", + "output": "Grade 2 Muscle Weakness Left-Sided, CTCAE (Finding)" + }, + { + "input": "Definition: Inhibitory Concentration Test described as an indication of reduced or increased susceptibility of a microbial organism, or activity of a biological/biochemical reaction in response to the inhibitory concentration (IC50 and/or IC95) of a specific drug.\nConcepts: Inhibitory Concentration Net Assessment (Laboratory Procedure)\tPODCI2-Global Functioning Scale (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tPART PER MILLION (Number Fraction Unit)\tDenture Cleaning Brushes, Disabled Person (Medical Device)\tHome Parenteral Nutrition (Home Care Services)", + "output": "Inhibitory Concentration Net Assessment (Laboratory Procedure)" + }, + { + "input": "Definition: Neoplastic Process described as a finding indicating the reemergence of high risk non-muscle invasive bladder urothelial carcinoma after a period of remission.\nConcepts: Recurrent High-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma (Neoplastic Process)\tV-MYB AVIAN MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG-LIKE 2 (Gene or Genome)\tPhosphorus-oxygen lyase -RETIRED- (Amino Acid, Peptide, or Protein)\tmultiple birth (Observation of delivery outcome)\tRecombinant Macrophage Colony-Stimulating Factor (Pharmacologic Substance)", + "output": "Recurrent High-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Partial trisomy of short arm of chromosome 8 described as a rare chromosomal anomaly syndrome, resulting from the partial duplication of the short arm of chromosome 8. The disease has a highly variable phenotype ranging from no dysmorphic features and only mild intellectual disability to patients with severe developmental delay, neonatal hypotonia, short stature, profound intellectual disability, mild dysmorphic features (for example mild ptosis, hypertelorism, down-slanting palpebral fissures, broad nasal bridge, short, prominent philtrum, abnormal dentition) and structural brain abnormalities. Autism, epilepsy, and spastic paraplegia have also been reported.\nConcepts: Low self-esteem (Self-esteem disturbance)\tCraniosynostosis, lambdoid (Craniosynostosis)\tnephropathy induced by heavy metals (Other kidney disorders)\tFAMS0151 (FAMS Questionnaire Question)\t8p+ syndrome (Partial trisomy of short arm of chromosome 8)", + "output": "8p+ syndrome (Partial trisomy of short arm of chromosome 8)" + }, + { + "input": "Definition: Medical Device described as an auditory impedance tester is a device that is intended to change the air pressure in the external auditory canal and measure and graph the mobility characteristics of the tympanic membrane to evaluate the functional condition of the middle ear. The device is used to determine abnormalities in the mobility of the tympanic membrane due to stiffness, flaccidity, or the presence of fluid in the middle ear cavity. The device is also used to measure the acoustic reflex threshold from contractions of the stapedial muscle, to monitor healing of tympanic membrane grafts or stapedectomies, or to monitor followup treatment for inflammation of the middle ear.\nConcepts: PTV (Cytoplasmic Vesicles)\tTympanometers (Medical Device)\tTyshchenko syndrome (Cardiovascular system hereditary disorder)\tcyanidin 3-O-glucoside-p-coumaroyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\taseptic viral meningitis (Korean Standard Classification of Disease Version 5)", + "output": "Tympanometers (Medical Device)" + }, + { + "input": "Definition: Finding described as a flat lesion, less than 2 cm in diameter, not raised above the surface of the surrounding skin\nConcepts: MEK inhibitor GDC-0623 (Organic Chemical)\toccluding junction organization (Cell Function)\tLACTIC ACID, DL- (D [Preparations])\tMacule, NOS (Lesion)\tDistance Source to Detector (Quantitative Concept)", + "output": "Macule, NOS (Lesion)" + }, + { + "input": "Definition: amino-acid betaine transport described as the directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.\nConcepts: anion transport (Ion Transport)\ttriangular nucleus, lateral lemniscus (Body Part, Organ, or Organ Component)\tVitamin BT transport (Cell Function)\tBronchopleural Fistula, CTCAE (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tIVD Test Reagent/Kits, Serology, Bacteria, Ehrlichia chaffeensis, Antibody (IVD Test Reagent/Kits, Serology, Bacteria, Ehrlichia Species, Antibody)", + "output": "Vitamin BT transport (Cell Function)" + }, + { + "input": "Definition: something described as the determination of the amount of fibroblast growth factor 21 present in a sample.\nConcepts: ARIA (Amino Acid, Peptide, or Protein)\tFibroblast Growth Factor 21 Measurement (Protein or Enzyme Type Measurement)\teIF-5A-deoxyhypusine synthase (Amino Acid, Peptide, or Protein)\tTMD receptor activity (Molecular Function)\tEster (carboxylic acid derivatives)", + "output": "Fibroblast Growth Factor 21 Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Hereditary Connective Tissue Disorder described as larsen-like syndrome, lethal type, has characteristics of multiple joint dislocation and respiratory insufficiency due to tracheomalacia and or lung hypoplasia. It has been described in less than ten patients. Transmission is thought to be autosomal recessive. Brain dysplasia has been described in some patients. Genetic factors have not been ruled out.\nConcepts: Interactive Ventilatory Support (Therapeutic or Preventive Procedure)\tLethal Larsen-like syndrome (Disease or Syndrome)\tADCIP01 (ADAS-Cog CDISC Version Questionnaire Question)\tcarbamoyl phosphate synthase complex location (Cell Component)\tregulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signaling pathway (Molecular Function)", + "output": "Lethal Larsen-like syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Treatment (General) described as services and programmes at a local, community, regional, state or national level, aimed at delivering interventions to individuals for their physical, psychological and social well-being, such as health promotion and disease prevention services, primary care services, acute care, rehabilitation and long-term care services; services that are publicly or privately funded, delivered on a short-term, long-term, periodic or one-time basis, in a variety of service settings such as community, home-based, school and work settings, general hospitals, speciality hospitals, clinics, and residential and non-residential care facilities, including those who provide these services.\nConcepts: Contrast Start (Identifier)\t\u00e1cido t\u00e1nico (Protective and Adsorbent Drugs)\tAnxiousness (Transfusion Reaction)\tChildhood B-Cell Acute Lymphoblastic Leukemia with t(9;22)(q34;q11.2); BCR-ABL1 (Childhood B Acute Lymphoblastic Leukemia)\tHealth Service (Health Care Activity)", + "output": "Health Service (Health Care Activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as histone H2A.J (129 aa, ~14 kDa) is encoded by the human H2AJ gene. This protein plays a role in chromatin formation.\nConcepts: SILICA GEL (Gel)\tH2AJ (Amino Acid, Peptide, or Protein)\tmeiosis II nuclear envelope breakdown (meiotic nuclear envelope disassembly)\tAtrial Closure Device (Medical Devices)\tRECEPT CILIARY NEUROTROPHIC FACTOR (Receptor)", + "output": "H2AJ (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Prostate carcinoma described as prostate carcinoma reemerging after a period of remission.\nConcepts: UPD114 (UPDRS Questionnaire Question)\tProstatic cancer recurrent (Prostatic neoplasms and hypertrophy)\tnociceptions (Organ or Tissue Function)\tCardiomyopathy, Familial Hypertrophic, 4 (Cardiomyopathy, Hypertrophic, Familial)\tnegative regulation of oogonium development (regulation of oogonium development)", + "output": "Prostatic cancer recurrent (Prostatic neoplasms and hypertrophy)" + }, + { + "input": "Definition: Receptor described as a transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.\nConcepts: Apoptosis Signal Regulating Kinase 1 (Amino Acid, Peptide, or Protein)\tPAD, MENSTRUAL, SCENTED (Menstrual Pad)\tKnowledge Discoveries (research)\tNiemann Pick C1 Protein (Amino Acid, Peptide, or Protein)\tCGC codon-amino acid adaptor activity (triplet codon-amino acid adaptor activity)", + "output": "Niemann Pick C1 Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as microbiology reagents intended to identify species of Leptospira, a genus of finely coiled, motile bacteria of the family Leptospiraceae. Leptospira interrogans bacteria are the pathogenic species to humans causing leptospirosis. Leptospirosis is acquired by direct contact with the urine or tissue of an infected animal (e.g., rodents, dogs) or indirectly by contact with contaminated water, soil, or vegetation.\nConcepts: DARBEPOETIN ALFA (Erythropoiesis-stimulating Agent [EPC])\tDental x-ray film holder (Diagnostic imaging equipment)\tbranching involved in mammary gland cord morphogenesis (branching involved in mammary gland duct morphogenesis)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Leptospira Species (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification)\tBeta Thalassemia Plus Structural Variants (Disease or Syndrome)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Leptospira Species (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as a population of allogeneic lymphocytes expressing the CD56 surface antigen and exhibiting a lack of CD3, with immunomodulating activity. Upon infusion of allogeneic CD56-positive CD3-negative natural killer (NK) cells, these cells are able to secrete cytokines and recognize and kill tumor cells as well as virally-infected cells. CD56 is a transmembrane glycoprotein also known as NCAM (Neural Cell Adhesion Molecule).\nConcepts: Allopathic & Osteopathic Physicians; Physical Medicine & Rehabilitation, Sports Medicine (Professional or Occupational Group)\tallogeneic CD56+CD3- NK cells (Allogeneic Lymphocyte)\tbodies dementia lewy (Neurological Disorders)\tHoloneocarzinostatin (Biologically Active Substance)\tIntracisternal Route of Drug Administration (Drug Administration Routes)", + "output": "allogeneic CD56+CD3- NK cells (Allogeneic Lymphocyte)" + }, + { + "input": "Definition: something described as human CRYAB wild-type allele is located within 11q22.3-q23.1 and is approximately 15 kb in length. This allele, which encodes alpha-crystallin B chain protein, plays a role in maintaining the structure of the lens. Mutation of the gene is associated with myofibrillar myopathy type 2, dilated cardiomyopathy type 1II; cataract 16 and alpha-B crystallin-related, fatal infantile hypertrophy myofibrillar myopathy.\nConcepts: SGRQC124 (SGRQ-C Questionnaire Question)\tCMD1II (Gene or Genome)\tNRAS Gly12Ser (Cell or Molecular Dysfunction)\tReceptor p75, Neurotrophin (Receptor)\tVerbal Rating Scale 4-Point (Verbal Rating Scale)", + "output": "CMD1II (Gene or Genome)" + }, + { + "input": "Definition: Human Phenotype Ontology described as being or representing the total number of individual entities.\nConcepts: all (Clinical or Research Assessment Answer)\tendothelial cell chemotaxis to fibroblast growth factor (endothelial cell chemotaxis)\tPerch, White (Fish)\tSubunit (Part)\tmethoxychloromethane (Organo-halide Carcinogen)", + "output": "all (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: DNA Ligation described as the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair.\nConcepts: ABT828 (Antineoplastic Biological Agent)\tDNA ligation involved in DNA repair (Genetic Function)\tTachycardia Syndrome, Postural (Orthostatic intolerance)\tparasite/microorganism carcinogen (Hazardous or Poisonous Substance)\tConcentration Maximum (Quantitative Concept)", + "output": "DNA ligation involved in DNA repair (Genetic Function)" + }, + { + "input": "Definition: Agglutination Tests described as a method for the detection of very small quantities of antibody in which the antigen-antibody-complement complex adheres to indicator cells, usually primate erythrocytes or nonprimate blood platelets. The reaction is dependent on the number of bound C3 molecules on the C3b receptor sites of the indicator cell.\nConcepts: adult AML in remission (Neoplastic Process)\tC-SSRS Baseline/Screening Version - Number of Actual Suicide Attempts (Intellectual Product)\tAdherence Reactions, Immune (Agglutination Tests)\tStage 0 Low-Grade Appendiceal Mucinous Neoplasm (LAMN) AJCC v8 (Appendix Carcinoma by AJCC v8 Stage)\tadenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway (Molecular Function)", + "output": "Adherence Reactions, Immune (Agglutination Tests)" + }, + { + "input": "Definition: Nonhematic cell described as any of the cells of the epithelium, which covers the body and lines its cavities and glands.\nConcepts: Epithelial cell (Human cells)\tCerumen abnormality (Finding)\tHDAC7B (Gene or Genome)\tRA factor, titer 1: (Rheumatoid factor positive)\tUnresectable Lung Neuroendocrine Neoplasm (Malignant neoplasm of lung)", + "output": "Epithelial cell (Human cells)" + }, + { + "input": "Definition: Congenital absence of part of brain described as a partial failure of the development of the corpus callosum.\nConcepts: Language (Conceptual Entity)\tGlobal Burden of Disease (Health Status Indicators)\tPartial agenesis of the corpus callosum (Agenesis of corpus callosum)\tTreatment Outcomes (Treatment (General))\tundef.U/A narr req'd (Laboratory Procedure)", + "output": "Partial agenesis of the corpus callosum (Agenesis of corpus callosum)" + }, + { + "input": "Definition: SPECIAL WARD CARE NURSING PROCEDURES described as actions performed to control the use of artificial teeth\nConcepts: Special care of dentures (regime/therapy)(procedure) (Intervention regimes)\tEuphoria (assessment of mood)\tmethenyltetrahydrofolate cyclohydrolase activity (cyclohydrolase activity)\tDIABETES, BRONZE (Diseases of Elements and Simple Compounds)\tPosterior Cerebellar Commissures (Body Space or Junction)", + "output": "Special care of dentures (regime/therapy)(procedure) (Intervention regimes)" + }, + { + "input": "Definition: something described as one of several chemotherapy regimens that include leucovorin calcium (calcium folinate), 5-fluorouracil and oxaliplatin and which may be used in the treatment of advanced-stage and metastatic colorectal cancer. FOLFOX regimens differ in agent dosing and administration schedule and include FOLFOX 4, FOLFOX 6, modified FOLFOX 6 (mFOLFOX 6) and FOLFOX 7.\nConcepts: Myxococcales (Bacterium)\tolfactory placode formation (Organism Function)\tLewis Acids (Inorganic Chemical)\tC250T (TERT Gene Mutation)\tCF/5-FU/L-OHP (Therapeutic or Preventive Procedure)", + "output": "CF/5-FU/L-OHP (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Receptor described as expressed by Alpha Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP.\nConcepts: Adrenergic alpha Receptors (G-Protein-Coupled Receptors)\tShort 3rd metacarpal (Short metacarpal)\tDistal monosomy 6p (Disease or Syndrome)\tCord Blood-derived CMV/AdV/EBV/BKV-specific Cytotoxic T-lymphocytes (Cell)\taedes (Aedini)", + "output": "Adrenergic alpha Receptors (G-Protein-Coupled Receptors)" + }, + { + "input": "Definition: something described as the day of the week the findings about an event or intervention was collected.\nConcepts: hypophysitis (Inflammatory disorder)\tVisual disturbance (Finding of sensation by site)\tFindings About Events or Interventions Data Collection Day (Temporal Concept)\tregulation of postsynapse to nucleus signaling pathway (Cell Function)\tFAC07510 (Intellectual Product)", + "output": "Findings About Events or Interventions Data Collection Day (Temporal Concept)" + }, + { + "input": "Definition: something described as a gastroenterology-urology biopsy instrument is a device used to remove, by cutting or aspiration, a specimen of tissue for microscopic examination. This generic type of device includes the biopsy punch, gastrointestinal mechanical biopsy instrument, suction biopsy instrument, gastro-urology biopsy needle and needle set, and nonelectric biopsy forceps. This section does not apply to biopsy instruments that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.\nConcepts: Somatosensory cortex (somatosensory nervous system)\tVENTILATOR, CONTINUOUS, MINIMAL VENTILATORY SUPPORT,FACILITY USE (Medical Device)\tintraocular pressure (Eye)\tINSTRUMENT, BIOPSY, SUCTION (Medical Device)\tupregulation of anion channel activity (positive regulation of ion transmembrane transporter activity)", + "output": "INSTRUMENT, BIOPSY, SUCTION (Medical Device)" + }, + { + "input": "Definition: Houseplants, garden ornamentals and exotics described as maidenhair fern.\nConcepts: CPB6 (Amino Acid, Peptide, or Protein)\tAdiantum capillus Sw. (Adiantum)\t1,4-Diaminobutane (BILIRUBIN COMPOUNDS AND BILE ACIDS)\tPhenylmercuric Acetate (phenylmercuric acetate)\tcolpectomy (Trunk excision)", + "output": "Adiantum capillus Sw. (Adiantum)" + }, + { + "input": "Definition: retinal binding described as interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A.\nConcepts: Powder and Solvent for Emulsion for Injection Dosage Form (Biomedical or Dental Material)\ttrans retinal binding (retinal binding)\tNotochordal process (Embryonic Structure)\tAUNT, BIOLOGICAL MATERNAL (Family Group)\tNigella sativa, homeopathic preparation (Homeopathic remedies letter N)", + "output": "trans retinal binding (retinal binding)" + }, + { + "input": "Definition: Was Molecular Analysis Performed described as a question asking if 10q23/PTEN deletion analysis was performed during the study.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Rapid Test, Cardiac Marker, Myoglobin (Medical Device)\t13: 32058624-32250157 (Chromosome 13 Physical Location)\tligand-gated channel activity (gated channel activity)\tWas 10q23/PTEN Locus Deletion Analysis Performed (Intellectual Product)\tcopper export (Cell Function)", + "output": "Was 10q23/PTEN Locus Deletion Analysis Performed (Intellectual Product)" + }, + { + "input": "Definition: Chromosome 19 Physical Location described as physical location of GLTSCR2_Gene\nConcepts: Normal Tissue Segment (Tissue specimen)\tmitochondrial inner membrane protein import (inner mitochondrial membrane organization)\tStudy Variable (Component of Study Protocol)\tPlace.typeCode (Intellectual Product)\t19: 52940620-52952127 (Chromosome 19 Physical Location)", + "output": "19: 52940620-52952127 (Chromosome 19 Physical Location)" + }, + { + "input": "Definition: Organic Chemical described as cyclized forms of acylated HOMOSERINE. Members are involved in bacterial QUORUM SENSING.\nConcepts: Annual Reports (organizational document)\tHomoserine Lactone, Acylated (Organic Chemical)\tMKMS (STAG2 gene)\tFIBROSIS (Fibrosis NEC)\tD-glucarate hydro-lyase activity (hydro-lyase activity)", + "output": "Homoserine Lactone, Acylated (Organic Chemical)" + }, + { + "input": "Definition: Data described as a datum that is presented to a user by a meter or similar instrument.\nConcepts: IPA03-Vigorous Leisure Hours per Day (Intellectual Product)\tADCS-ADL MCI - Time Taken to Complete Complex Activities (Intellectual Product)\tMicrobiology Susceptibility Link Identifier (Intellectual Product)\tReading (Conceptual Entity)\tMHTERM (Intellectual Product)", + "output": "Reading (Conceptual Entity)" + }, + { + "input": "Definition: Medical Device described as serology reagents intended to detect exotoxins from Clostridium perfringens, a species of bacterium of the family Bacillaceae. Clostridium perfringens bacteria grow in large numbers and produce a protein exotoxin in sufficient amounts to cause gas gangrene and/or necrotizing colitis.\nConcepts: glandular fever (Exfoliative dermatitis)\tIVD Test Reagent/Kits, Serology, Bacteria, Clostridium perfringens, Toxin (Medical Device)\t(cis)-N-((S)-1-(6-(4-Fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)-1-methoxy-4-(4-methyl-6-(5-methyl-1H-pyrazol-3-ylamino)pyrimidin-2-yl)cyclohexanecarboxamide (Pharmacologic Substance)\tBlasts 21-30 Percent of Bone Marrow Nucleated Cells (Blasts 20 Percent or More of Bone Marrow Nucleated Cells)\tmitotic telomere maintenance via semi-conservative replication (Genetic Function)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Clostridium perfringens, Toxin (Medical Device)" + }, + { + "input": "Definition: something described as an increased amount of nicotinurate in the blood. []\nConcepts: Milligram per centimeter squared (Unit of Spread Rate of Substance by Mass)\tRambaud Gallian Touchard syndrome (Disease or Syndrome)\tIncreased circulating N-nicotinoylglycine level (Finding)\tCzrn sxn prep ea.15min (Care of patient states)\tCone-shaped epiphysis of the middle phalanx of the 4th finger (Anatomical Abnormality)", + "output": "Increased circulating N-nicotinoylglycine level (Finding)" + }, + { + "input": "Definition: Bacterium described as a species of anaerobic, Gram-negative, fusiform rod shaped bacteria in the phylum Fusobacteria. This species is non-spore forming, indole, catalase, urease, lipase, esculin and oxidase negative, does not produce hydrogen sulfide, but does reduce nitrate, produce large amounts of butyrate, and converts threonine to propionic acid. F. ulcerans causes ulcers in humans located in tropical nations however, this bacteria's natural habitat is unknown.\nConcepts: FAC06148 (FACT-BMT Version 4 Questionnaire Question)\tFusibacterium ulcerans (Genus Fusobacterium)\tPulmonary Artery Angiosarcoma (Neoplastic Process)\tL-phenylalanine synthesis (erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process)\tneuron migration (Cell Function)", + "output": "Fusibacterium ulcerans (Genus Fusobacterium)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a blood vessel that supplies blood to the muscles of the neck.\nConcepts: Cervical Artery (Precerebral artery)\tBONE MORPHOGENETIC PROTEIN 15 (Bone Morphogenetic Protein Gene)\tLimb-girdle muscular dystrophy 2O POMGNT1 gene mutation (Autosomal recessive muscular dystrophy with limb girdle distribution)\tLOXO-305 (BTK Inhibitor)\tAdenosine diphosphate measurement (Laboratory Procedure)", + "output": "Cervical Artery (Precerebral artery)" + }, + { + "input": "Definition: something described as a Chinese person from the Va ethnic group.\nConcepts: Ivory epiphysis of the middle phalanx of the 3rd finger (Abnormality of the epiphysis of the middle phalanx of the 3rd finger)\toxyCODONE hydrochloride (Central depressant)\tReplacement Of Lens (Ophthalmologic Surgical Procedures)\tVA (Population Group)\tcellular response to sucrose stimulus (cellular response to disaccharide stimulus)", + "output": "VA (Population Group)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 9q\nConcepts: CSR Synopsis (Clinical Study Reports and Related Information)\tphotodesensitizers afamelanotide (Peptide hormone-containing product)\tHuntington disease-like syndrome due to C9ORF72 expansions (Hereditary degenerative disease of central nervous system)\t9q31 (Chromosome band)\tVELTUZUMAB (Pharmacologic Substance)", + "output": "9q31 (Chromosome band)" + }, + { + "input": "Definition: Somatoform Disorder described as a disorder whose predominant feature is a loss or alteration in physical functioning that suggests a physical disorder but that is actually a direct expression of a psychological conflict or need.\nConcepts: sulfur:ferric ion oxidoreductase activity (Molecular Function)\tConversion Reaction (Disturbance of perception associated with conversion and dissociative phenomenon)\tProduct containing peramivir (Anti-influenza Agents)\tGMSS0107 (GMSS Version Type 1 Diabetes Questionnaire Question)\tdolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p dimer (dolichyl-phosphate-mannose-protein mannosyltransferase complex)", + "output": "Conversion Reaction (Disturbance of perception associated with conversion and dissociative phenomenon)" + }, + { + "input": "Definition: Vasculitis described as inflammation of a vein.\nConcepts: cochlear nuclei - not otherwise specified (Body Part, Organ, or Organ Component)\tEducation, Pharmaceutic, Graduate (Graduate Education)\tInflammation of vein, NOS (Vascular Diseases)\tCement, Silicate (Biomedical or Dental Material)\tPOROUS POLYETHYLENE OSSICULAR REPLACEMENT (Medical Device)", + "output": "Inflammation of vein, NOS (Vascular Diseases)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in folate and antifolate transport.\nConcepts: solute carrier family 46 (folate transporter), member 1 (Transport Protein Gene)\tArizona Sexual Experiences Scale-Female Version Questionnaire (Intellectual Product)\tComputerized Gait Training Exercisers (Medical Device)\tECoG (Diagnostic Procedure)\tBCDO (Gene or Genome)", + "output": "solute carrier family 46 (folate transporter), member 1 (Transport Protein Gene)" + }, + { + "input": "Definition: Diagnosis described as detection and classification of disease which is accomplished in a brief period of time.\nConcepts: Therapies, Situational (Psychotherapy Procedures)\tdiagnosis rapid (Diagnosis)\tMuscle Weakness Lower Limb (Musculoskeletal and Connective Tissue Disorders, CTCAE)\tHP1 gamma Homolog Gene (CBX3 gene)\tLysosome (Membranous cytoplasmic organelle)", + "output": "diagnosis rapid (Diagnosis)" + }, + { + "input": "Definition: Educational Activity described as instruction or training that encourages behaviors most likely to optimize health potentials through information about neoplasms and cancer; facilitates the prevention of cancer, frequently for those who are at risk; also includes instruction or training that increases the awareness and favorably influences the attitudes and knowledge about neoplasms and cancer on a personal or community basis; it also includes the training of medical personnel about cancer for prevention or treatment programs, for this type of cancer education postcoordinate with the appropriate health professional education term; this concept may overlap with CANCER PREVENTION.\nConcepts: Colorectal Cancer pN2 TNM Finding v7 (Colorectal Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tGrade 3 Infantile Vomiting, AE (Infantile Vomiting, Adverse Event)\tneoplasm/cancer education (Health education)\td.mmol/L/(mg/g/d) (Measurement Unit Description)\tSARSAPARILLA (Pharmacologic Substance)", + "output": "neoplasm/cancer education (Health education)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea 10 Item Short Form - Part II Functional Limitation. Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Dressing yourself without help.\nConcepts: Telephones, Bedside, Disposable (Medical Device)\tFACIT-Dyspnea 10 Item Short Form - Part II: Dressing Without Help (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)\tFormation of new noncancerous bone on top of existing bone (Disorder of body system)\tFood and Drug Administration Drug Approval (Governmental or Regulatory Activity)\tInhibitor Of Differentiation Protein (Biologically Active Substance)", + "output": "FACIT-Dyspnea 10 Item Short Form - Part II: Dressing Without Help (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)" + }, + { + "input": "Definition: Syringes, Plunger, Arterial Blood Sampling, Protective described as blood-sampling plunger syringes usually with a needle preattached to their Luer-lock tip that are designed to provide needlestick protection (safety). These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, to lessen the possibility of contact of the healthcare provider with a sharp needle. Luer-lock tapers include an internally threaded skirt or other structure around the taper, adding additional strength to the connection with a female Luer taper.\nConcepts: IGA Gene Mutation (Gene Mutant)\tHorizontal Cell of Cajal (Fusiform cell)\tSymbolic Interactionism (perspectives in sociology and anthropology)\tSyringes, Plunger, Arterial Blood Sampling, Protective, Luer Lock (Medical Device)\tCan Take on a Lot Physically (Intellectual Product)", + "output": "Syringes, Plunger, Arterial Blood Sampling, Protective, Luer Lock (Medical Device)" + }, + { + "input": "Definition: something described as 1) Reddish in color. 2) relating to erythrocytes or their precursors.\nConcepts: Biological Bladder Support Implants (Bladder Support Implants)\tParanoia (Personality Traits)\tIPA0209D (Intellectual Product)\tErythroid (Qualitative Concept)\tFAC07113 (Intellectual Product)", + "output": "Erythroid (Qualitative Concept)" + }, + { + "input": "Definition: Informatics described as the process of creating a summary of the main points of an article, argument, or theory.\nConcepts: Ornithine (Laboratory Procedure)\tIn the past 7 days, how often did you have hot flashes (Clinical or Research Assessment Question)\tReverse Transcription Process (RNA-dependent DNA biosynthetic process)\tRenal agenesis, unilateral (Unilateral clinical finding)\tAbstracting as Topic (alteration integrity)", + "output": "Abstracting as Topic (alteration integrity)" + }, + { + "input": "Definition: Neurotransmitter Uptake Inhibitors described as drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants (ANTIDEPRESSIVE AGENTS, TRICYCLIC) and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.\nConcepts: Special Populations Networks (Consortium or Network)\tIkaros (Transcription factor genes)\tpyrimidine nucleotide-sugar transmembrane transport (nucleotide-sugar transmembrane transport)\tREUPTAKE INHIB ADREN (Pharmacologic Substance)\tBenzoic acid, 2-hydroxy-6-methyl-, (5-((3-acetylphenyl)amino)-4-amino-3-(((dimethylamino)carbonyl)amino)-1,2-dihydroxy-3-(1-hydroxyethyl)-2-methylcyclopentyl)methyl ester, (1S-(1alpha,2beta,3alpha,3(R*),4alpha,5beta))- (Hydroxybenzoic Acids)", + "output": "REUPTAKE INHIB ADREN (Pharmacologic Substance)" + }, + { + "input": "Definition: Dryers, Medical-Air described as medical-air dryers designed to remove moisture from the air using dynamic desiccant adsorption techniques. These dryers typically include a set of desiccants (e.g., a bed of desiccant cores) in which the adsorption process is performed; frequently, the compressed air to be dried passes through a rotor while the desiccant removes water vapor directly from the air and holds it while the wheel rotates. Desiccating medical-air dryers may be equipped with filters for removing liquid, oil, aerosols, and mists with purifiers for removing solid and liquid particles and gaseous impurities such as carbon monoxide; these devices are frequently included as an integral part of medical-air supply systems.\nConcepts: Dryers, Medical-Air, Desiccating (Dryers, Medical-Air)\tMLCRD (microcephaly with or without chorioretinopathy, lymphoedema or intellectual disability) syndrome (Congenital anomaly of brain)\tspin label (Indicator, Reagent, or Diagnostic Aid)\tHoarseness, CTCAE (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tD-glucose-6-phosphate phosphohydrolase activity (sugar-terminal-phosphatase activity)", + "output": "Dryers, Medical-Air, Desiccating (Dryers, Medical-Air)" + }, + { + "input": "Definition: Endocrine system described as a system of neurosecretory neurons that release hormones to the circulatory system.\nConcepts: Neurosecretory System (Endocrine system)\tTriangle of Morgagni (Body Space or Junction)\tGEN1 wt Allele (GEN1 gene)\tVacuolated Neutrophils (Laboratory Procedure)\tpeptide antigen assembly with MHC protein complex (Molecular Function)", + "output": "Neurosecretory System (Endocrine system)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a portion of the periaqueductal gray. It, the lateral subnucleus of the midbrain central gray and the dorsal subnucleus of the midbrain central gray, constitute the periaqueductal gray ( Beitz-1990 ).\nConcepts: MOU (Transaction counts and value totals - contract)\tGriseum centrale mesencephali, subnucleus medialis (Body Part, Organ, or Organ Component)\tDetectors, Metallic Foreign Body, Magnetic (Detectors, Metallic Foreign Body)\tImpaired smooth pursuit (Abnormality of ocular smooth pursuit)\tDRD4 (Receptor)", + "output": "Griseum centrale mesencephali, subnucleus medialis (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Developmental stages described as developmental stage from 9 to 11 years.\nConcepts: ERT - Number Stimuli Portraying Happiness (Intellectual Product)\tALDH2 Protein (Mitochondrial Proteins)\tED1-Require Physical Assistance (Expanded DRS-PI Caregiver Version Questionnaire Question)\tPre-adolescent stage (Developmental stages)\tIntestinal Stoma Site Bleeding, CTCAE (Finding)", + "output": "Pre-adolescent stage (Developmental stages)" + }, + { + "input": "Definition: Lung Cancer by AJCC v6 Stage described as stage IV includes: Any T, Any N, M1. M1: Distant metastasis present.\nConcepts: N-terminal peptidyl-glycine N-formylation (N-terminal protein formylation)\tStage IV Carcinoma of Lung AJCC v6 (Neoplastic Process)\tFloor-Mounted Facility Booms (Medical Device)\tenzyme active site formation via S-sulpho-L-cysteine (Molecular Function)\tURG7 (Translocase Gene)", + "output": "Stage IV Carcinoma of Lung AJCC v6 (Neoplastic Process)" + }, + { + "input": "Definition: Neoplastic Process described as hydatidiform mole (HM) is an aberrant human pregnancy with absence of, or abnormal embryonic development, hydropic degeneration of chorionic villi, and excessive proliferation of the trophoblast.\nConcepts: Reactivation (Activity)\tcholesteatomas (Benign neoplasm of ear)\tInfraclavicular, right (Finding)\tInstalling the app (Clinical or Research Assessment Answer)\thydatidiform moles (Pregnancy)", + "output": "hydatidiform moles (Pregnancy)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing three carboxyl (-COOH) groups.\nConcepts: Cortical Cataract Grade 2 (Disease or Syndrome)\tAbnormal Fissure (Finding)\tSubcutaneous Port Injection Needles (NEEDLES,INJECTION)\ttricarboxylic acid anabolism (carboxylic acid biosynthetic process)\tBothered by Pain with Intercourse (Clinical or Research Assessment Question)", + "output": "tricarboxylic acid anabolism (carboxylic acid biosynthetic process)" + }, + { + "input": "Definition: Finding described as an abnormal catecholamine concentration in the blood.\nConcepts: Risk for vascular trauma (Finding)\tCatecholamine levels abnormal (Abnormal circulating hormone level)\tFibroadenoma of Anogenital Mammary-Like Glands (Neoplastic Process)\tLate Relapse of Acute Lymphoblastic Leukemia (Finding)\tIn-Transit Metastasis of Cutaneous Melanoma (In-Transit Metastasis)", + "output": "Catecholamine levels abnormal (Abnormal circulating hormone level)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a copper test system is a device intended to measure copper levels in plasma, serum, and urine. Measurements of copper are used in the diagnosis and treatment of anemia, infections, inflammations, and Wilson's disease (a hereditary disease primarily of the liver and nervous system). Test results are also used in monitoring patients with Hodgkin's disease (a disease primarily of the lymph system).\nConcepts: regulation of protein K63-linked deubiquitination (Molecular Function)\tBASAL (Spatial Concept)\tB-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage (Non-Hodgkin Lymphoma by Ann Arbor Stage)\tdeficiency; adenosine deaminase (Enzymopathy)\tOXALYDIHYDRAZIDE (SPECTROSCOPIC), COPPER (Indicator, Reagent, or Diagnostic Aid)", + "output": "OXALYDIHYDRAZIDE (SPECTROSCOPIC), COPPER (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I went on combat patrols or missions.\nConcepts: Motor Areas, Primary (Cerebral cortex)\tDNA Catenanes (Biologically Active Substance)\tDRRI-2 - D: Went on Combat Patrols/Missions (Intellectual Product)\tASCIZ (Regulatory Protein)\tradiation; colitis (Colitis)", + "output": "DRRI-2 - D: Went on Combat Patrols/Missions (Intellectual Product)" + }, + { + "input": "Definition: Refractory cancer described as a neuroblastoma that does not respond to treatment.\nConcepts: Hypermedia (Computer software)\tHAMD2-Depressed Mood (Intellectual Product)\tCERULOPLASMIN, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tL-phenylalanine synthesis from chorismate via L-arogenate (L-phenylalanine biosynthetic process)\tRefractory Neuroblastoma (Refractory cancer)", + "output": "Refractory Neuroblastoma (Refractory cancer)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of fumigaclavine C biosynthetic process.\nConcepts: Ovarian Sex Cord-Stromal Tumor Associated with Peutz-Jeghers Syndrome (Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types)\tNatives, American (Indians, North American)\tnegative regulation of fumigaclavine C biosynthetic process (regulation of fumigaclavine C biosynthetic process)\tSGN-CD70A (Immunologic Factor)\t18: 59137025-58941558 (Chromosome 18 Physical Location)", + "output": "negative regulation of fumigaclavine C biosynthetic process (regulation of fumigaclavine C biosynthetic process)" + }, + { + "input": "Definition: Nutraceuticals described as perque(TM) A/02 Antioxidant Formula each 120 tablets. UPC Code 791760014900.\nConcepts: brochure (Manufactured Object)\tLithium Induced Birth Defect (Congenital Abnormality)\tDistal revascularisation and interval ligation (cardiovascular surgery arteriovenous)\tVitritis, NOS (Disorder of vitreous body)\tperque a/02antioxidant frmul (Nutraceuticals)", + "output": "perque a/02antioxidant frmul (Nutraceuticals)" + }, + { + "input": "Definition: Classification described as a scoring system for liver fibrosis developed by Scheuer (Scheuer PJ. Classification of viral hepatitis: a need for reassessment. J Hepatol 1991;13:372-374), based on a 5 category scale.\nConcepts: Biopsychosocial Approach (Treatment (General))\tInfiltrating Intramuscular Lipoma (Intramuscular lipoma)\tSCHEUER FIBROSIS SCORE (Disease Grade Qualifier)\tOpitz BBBG Syndrome, Type I (Laryngeal cleft)\tHUMANITARIAN DEVICE EXEMPTION (Medical Device)", + "output": "SCHEUER FIBROSIS SCORE (Disease Grade Qualifier)" + }, + { + "input": "Definition: ileum described as the veins that drain blood from the ileum into the superior mesenteric vein.\nConcepts: Fetal finding (Other Finding)\tIleal vein structure (Structure of superior mesenteric vein)\tSkin Closure Adhesive Strip Bandages (Skin cleaning/protecting device)\tPI3K-DELTA (Gene or Genome)\tPhosphocholine Cytidylyl-Transferase, CTP (Enzymes)", + "output": "Ileal vein structure (Structure of superior mesenteric vein)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of CXC Chemokine Receptor 4 (CXCR4) with potential antineoplastic activity. CXCR4 antagonist BL-8040 selectively binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor 1 (SDF-1 or CXCL12) to the CXCR4 receptor and subsequent receptor activation, which may result in decreased tumor cell proliferation and migration. In addition, inhibition of CXCR4 may induce mobilization of hematopoietic cells from the bone marrow into blood. The G protein-coupled receptor CXCR4 plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types; SDF-1/CXCR4 interaction induces retention of hematopoietic cells in the bone marrow.\nConcepts: PPAT (Gene or Genome)\tHDAC3 wt Allele (HDAC3 gene)\tFRUCTOSE (biochemical test)\tN-(4-fluoro-benzoyl)-l-arginyl-l-arginyl-(l-3-(naphthyl)alanyl)-l-cysteinyl-l-tyrosyl-l-citrullinyl-l-lysyl-d-lysyl-l-prolyl-l-tyrosyl-l-arginyl-l-citrullinyl-l-cysteinyl-l-arginine Amide,Cyclic (4-13)-disulfide (Pharmacologic Substance)\tCATHETER AND TUBE, SUPRAPUBIC (Device associated with urological catheter)", + "output": "N-(4-fluoro-benzoyl)-l-arginyl-l-arginyl-(l-3-(naphthyl)alanyl)-l-cysteinyl-l-tyrosyl-l-citrullinyl-l-lysyl-d-lysyl-l-prolyl-l-tyrosyl-l-arginyl-l-citrullinyl-l-cysteinyl-l-arginine Amide,Cyclic (4-13)-disulfide (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a species of gram-negative, aerobic bacteria that consist of slender vibroid cells.\nConcepts: SUN STROKE (Injury or Poisoning)\tnegative regulation of cap-independent translational initiation (regulation of cap-independent translational initiation)\tpuerperal infection (Disease or Syndrome)\tRAD30, S. cerevisiae, Homolog of, A Gene (Gene or Genome)\tCaulobacter crescentus (Bacterium)", + "output": "Caulobacter crescentus (Bacterium)" + }, + { + "input": "Definition: Nerve Growth Factors described as a factor identified in the brain that influences the growth and differentiation of NEURONS and NEUROGLIA. Glia maturation factor beta is the 17-kDa polypeptide product of the GMFB gene and is the principal component of GLIA MATURATION FACTOR.\nConcepts: Protein, Mutant (Amino Acid, Peptide, or Protein)\tGlial Maturation Factor (Nerve Growth Factors)\tAnti-p53 T-Cell Receptor Retroviral Vector-Transduced Peripheral Blood Lymphocytes (Peripheral Blood Lymphocyte Vaccine)\tLoeys-Dietz Syndrome Gene Panel Reagents (Medical Device)\tMRSD (Hereditary disorder of musculoskeletal system)", + "output": "Glial Maturation Factor (Nerve Growth Factors)" + }, + { + "input": "Definition: Quantitative Concept described as the number of subject lymph nodes that were positive for presence of disease.\nConcepts: viral myocarditis (Viral infections NEC)\tLMNDPNUM (Quantitative Concept)\tNF45 Protein (Nuclear Factor 90 Proteins)\tpT1b Corpus Uteri Carcinoma TNM Finding v6 (Finding)\tAortic insufficiency: cardiac murmur of AI (Cardio-vascular Findings: Heart)", + "output": "LMNDPNUM (Quantitative Concept)" + }, + { + "input": "Definition: Neoplastic Process described as a morphologic variant of papillary carcinoma of the thyroid gland that predominantly affects children. It is characterized by the presence of a solid growth pattern. The malignant cells have nuclear features that are characteristic of papillary carcinomas of the thyroid gland.\nConcepts: ARHGAP45 Gene Mutation (Cell or Molecular Dysfunction)\tpT1 Tumor Finding (TNM classification of malignant tumor after operation)\tPIM447 (Antineoplastic Enzyme Inhibitor)\tSolid/Trabecular Variant Thyroid Gland Papillary Carcinoma (Neoplastic Process)\t19: 13074681-13070848 (Chromosome 19 Physical Location)", + "output": "Solid/Trabecular Variant Thyroid Gland Papillary Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Left ventricular abnormality described as any structural anomaly of the papillary muscles of the left ventricle.\nConcepts: M2 Macrophage (Cell)\tMorphological abnormality of the papillary muscles (Left ventricular abnormality)\tInositol Phosphate (Sugar Phosphates)\tDACH Polymer Platinate AP5346 (Pharmacologic Substance)\tsodium-independent eicosanoid transport (Cell Function)", + "output": "Morphological abnormality of the papillary muscles (Left ventricular abnormality)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how an individual considers their health status in comparison to others of the same age.\nConcepts: 162 KOSERELLA (Yokenella)\tSM (Country)\tmmol/min (Moles per unit time)\tComparison of Health Status (Intellectual Product)\tcellular glycan metabolism (cellular macromolecule metabolic process)", + "output": "Comparison of Health Status (Intellectual Product)" + }, + { + "input": "Definition: something described as change in delivery access of enteral formula (e.g, jejunal vs. nasogastric feeding tube)\nConcepts: NF-kB Signaling Pathway (Signal Transduction Pathways)\tManagement of route of enteral nutrition (Enteral feeding management)\tTSCYC181 (Intellectual Product)\tC. difficile Glutamate Dehydrogenase (Clinical Attribute)\tTSCYC1-Acting Sad or Depressed (TSCYC Questionnaire Question)", + "output": "Management of route of enteral nutrition (Enteral feeding management)" + }, + { + "input": "Definition: Disease of Skin and Appendages described as a fungal infection of the nail, usually caused by DERMATOPHYTES; YEASTS; or nondermatophyte MOLDS.\nConcepts: growth hormone receptor activity (cytokine receptor activity)\thepatitis; virus, type, B (Hepatitis, Viral, Human)\tonychomycosis (Onychomycosis due to dermatophyte)\tIVD Test Reagent/Kits, Immunoassay, Control, Protein (IVD Test Reagent/Kits, Immunoassay, Control)\tGrade 2 Edema Trunk, CTCAE (Edema Trunk, CTCAE)", + "output": "onychomycosis (Onychomycosis due to dermatophyte)" + }, + { + "input": "Definition: something described as a region created by territorial division for the purpose of local government.\nConcepts: Spinal cord sulcus (Body Space or Junction)\tDetergents, Ultrasonic Cleaning System (Biomedical or Dental Material)\tTricuspid valve disease (Cardiac Disorders, CTCAE)\tCounty (Geographic Area)\tFood Insecurities (Community resource finding)", + "output": "County (Geographic Area)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation.\nConcepts: Low polyunsaturated fat diet (Fat-Restricted Diet)\tglycosyl compound metabolism (Molecular Function)\tregulation of ureter smooth muscle cell differentiation (Biologic Function)\tEsophageal squamous cell carcinoma stage IV (Squamous cell carcinoma of esophagus)\tBreast Neoplasm (Intellectual Product)", + "output": "regulation of ureter smooth muscle cell differentiation (Biologic Function)" + }, + { + "input": "Definition: something described as any deviation from the normal concentration of a nitrogen compound in the blood circulation.\nConcepts: Abnormal circulating nitrogen compound concentration (Finding)\tPPBP (Laboratory Procedure)\tSARS-related coronavirus (Subgenus Sarbecovirus)\tBALB/C (Mammal)\tendocrine process (system process)", + "output": "Abnormal circulating nitrogen compound concentration (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as circadian clock protein PASD1 (773 aa, ~87 kDa) is encoded by the human PASD1 gene. This protein may be involved in the regulation of transcription.\nConcepts: Adrenal Gland Ganglioneuroma (Neoplastic Process)\tRefrain from Smoking When Having Coffee or Tea (Clinical or Research Assessment Question)\tAmber color (Color)\tPAS Domain-Containing Protein 1 (Amino Acid, Peptide, or Protein)\tsmooth muscle (SOFT TISSUES, SMOOTH MUSCLE AND CARTILAGINOUS TISSUES)", + "output": "PAS Domain-Containing Protein 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as those funds disbursed for facilities and equipment, particularly those related to the delivery of health care.\nConcepts: Dyspnoea paroxysmal nocturnal (respiratory)\tconnecting tubule development (nephron tubule development)\tExpenditures, Capital (Health Expenditures)\tprotein location to meiotic spindle pole body (Cell Function)\tADL01-Find Belongings (Intellectual Product)", + "output": "Expenditures, Capital (Health Expenditures)" + }, + { + "input": "Definition: conversation described as finishing an interchange or dialogue with customary termination statements or expressions and by bringing closure to the topic under discussion.\nConcepts: SAP97 (Gene or Genome)\tCSS08-Number of Interrupt Attempts (Intellectual Product)\tEnding a conversation (Social Behavior)\tSoftware, Physiologic Monitoring, Electrocardiography (Software, Physiologic Monitoring)\tmitotic spindle microtubule (Spindle microtubule)", + "output": "Ending a conversation (Social Behavior)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as uncharacterized protein C9orf72 (481 aa, ~54 kDa) is encoded by the human C9orf72 gene. This protein may play a role in cell death.\nConcepts: ULNA SHAFT (Body Part, Organ, or Organ Component)\tprocess utilizing autophagic mechanism (cellular process)\tnegative regulation of RANTES production (negative regulation of chemokine production)\tFIGO Stage IC Ovarian Carcinoma (Neoplastic Process)\tUncharacterized Protein C9orf72 (Regulatory Protein)", + "output": "Uncharacterized Protein C9orf72 (Regulatory Protein)" + }, + { + "input": "Definition: something described as painful sensation in the bladder region.\nConcepts: Wnt Family Member 5A Gene (Gene or Genome)\tpain bladder (Urinary symptom/complaint other)\tinhibition of dopamine uptake involved in synaptic transmission (negative regulation of dopamine uptake involved in synaptic transmission)\tADENOMA, ACINAR CELL, BENIGN (Benign acinar cell tumor)\tADT0109 (Intellectual Product)", + "output": "pain bladder (Urinary symptom/complaint other)" + }, + { + "input": "Definition: something described as the process in which vesicles are directed to specific destination membranes during transport to, from or within the Golgi apparatus; mediated by the addition of specific coat proteins, including COPI and COPII proteins and clathrin, to the membrane during vesicle formation.\nConcepts: FGFBF (Protein or Enzyme Type Measurement)\tCyclin B1 Peptide-pulsed Autologous Dendritic Cell Vaccine (Pharmacologic Substance)\tgp100 Peptide-sensitized Autologous T-cells (therapeutic autologous lymphocytes)\tDescending aortic dissection (Disease or Syndrome)\tGolgi vesicle targeting (Cell Function)", + "output": "Golgi vesicle targeting (Cell Function)" + }, + { + "input": "Definition: Urinary Incontinence described as urination during sleep.\nConcepts: AVL01050 (ADNI-AVLT Questionnaire Question)\tTatumella species (Bacterium)\thypoglossal nerve maturation (Organ or Tissue Function)\tenuresis bedwetting (Other specified urinary incontinence)\tOrthoses, Upper Limb, Shoulder-Elbow (Arm appliance)", + "output": "enuresis bedwetting (Other specified urinary incontinence)" + }, + { + "input": "Definition: Disease or Syndrome described as a condition caused by the presence of an extra Y chromosome resulting in 47,XYY karyotype in an individual with male phenotype. The condition is characterized by tall stature, increased risk of learning disabilities, and delayed development of speech and language. Testicular function and size are normal.\nConcepts: pulmonary sulcus tumor (Neoplastic Process)\tdibenzofuran breakdown (organic cyclic compound catabolic process)\tCNS Solitary Fibrous Tumor/Hemangiopericytoma, Grade 2 (Central Nervous System Solitary Fibrous Tumor/Hemangiopericytoma)\tExperimental Unit Status Date (Status Date)\tkaryotype xyy (Sex chromosome abnormality - male phenotype)", + "output": "karyotype xyy (Sex chromosome abnormality - male phenotype)" + }, + { + "input": "Definition: Gene or Genome described as human EEF1A1 wild-type allele is located in the vicinity of 6q14.1 and is approximately 6 kb in length. This allele, which encodes elongation factor 1-alpha 1 protein, plays a role in the modulation of protein synthesis. The gene is associated with an autoimmune disease, Felty's syndrome.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Legionella Species (Medical Device)\tPTI1 (Gene or Genome)\tGlycosphingolipid (Pharmacologic Substance)\tSmallest (Quantitative Concept)\tFagus sylvatica / beech nut (Organic Chemical)", + "output": "PTI1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle.\nConcepts: Scissors, Surgical, Brain (Surgical Scissors)\tperipheral B cell positive selection (B cell positive selection)\tmitotic G2/M transition checkpoint (Cell Function)\tCLASP, WIRE (Medical Device)\tMSQL145 (MSQOL-54 Questionnaire Question)", + "output": "mitotic G2/M transition checkpoint (Cell Function)" + }, + { + "input": "Definition: Gene or Genome described as human PPM1D wild-type allele is located in the vicinity of 17q23.2 and is approximately 64 kb in length. This allele, which encodes protein phosphatase 1D protein, is involved in the regulation of cell cycle progression. Gene amplification is associated with breast cancer.\nConcepts: dephosphorylation (Molecular Function)\tNorth (Spatial Concept)\tROS1 Rearrangement Analysis Testing Method (Intellectual Product)\tProtein Phosphatase, Magnesium-Dependent, 1, Delta Isoform Gene (Gene or Genome)\tActinobacillus (Actinobacillus)", + "output": "Protein Phosphatase, Magnesium-Dependent, 1, Delta Isoform Gene (Gene or Genome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an epoxide-containing cyclotetrapeptide with antitumor activity. It is an irreversible inhibitor of histone deacetylase.\nConcepts: Energy, Physics (basic physical science concepts)\tthreonine synthetase activity (carbon-oxygen lyase activity, acting on phosphates)\tGrade 3 Esophageal obstruction (Finding)\tAnterior Optic Tract Meningioma (Visual Pathway Meningioma)\tTrapoxin (Pharmacologic Substance)", + "output": "Trapoxin (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as the progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.\nConcepts: aorta development (Organ or Tissue Function)\tOvarian Clear Cell Adenocarcinoma (Malignant epithelial tumor of ovary)\tPLATAGRN (Cell Count)\tApplicable Regulatory Requirement (Intellectual Product)\treductions (Oxidation-Reduction)", + "output": "aorta development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as plant diseases affecting mostly leaves where either plant cells or tissues are dead and/or collapsed (necrosis) or yellowed due to loss of CHLOROPHYLL (chlorosis).\nConcepts: new safety information (Information)\tPlant Chlorosis and Necrosis (Plant Diseases)\t19p13.3 (Cell Component)\tNogai (Northwestern Turkic language)\tDNA-5-methylcytosine glycosylase activity (alkylbase DNA N-glycosylase activity)", + "output": "Plant Chlorosis and Necrosis (Plant Diseases)" + }, + { + "input": "Definition: regulation of substance P secretion described as any process that stops, prevents or reduces the frequency, rate or extent of substance P secretion.\nConcepts: Platelet Count 20,000 per cubic millimeter (Abnormal Hematology Test Result)\tBackground Treatment (Pharmacologic Substance)\tB2G1GAAB (Immunologic Tests)\thormones metabolism (regulation of hormone levels)\tdown-regulation of substance P secretion (negative regulation of peptide hormone secretion)", + "output": "down-regulation of substance P secretion (negative regulation of peptide hormone secretion)" + }, + { + "input": "Definition: DNA-dependent DNA replication described as the process in which new strands of DNA are synthesized in a plastid.\nConcepts: Seat Lifters (Medical Device)\treplication of plastid DNA (Genetic Function)\tasini gelatinum/ah jao (Plant)\tCONGEN (Etiology aspects)\tacrylonitrile hydratase activity (hydro-lyase activity)", + "output": "replication of plastid DNA (Genetic Function)" + }, + { + "input": "Definition: Molecular Function described as the process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction.\nConcepts: positive regulation of heart contraction rate by adrenaline-noradrenaline (Molecular Function)\tBiventricular part of heart (Zone of heart)\t1-(2-fluoro-6-dimethylaminobenzoyl)-3-(4-chlorophenyl)urea (Organic Chemical)\tPQL1424 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)\tMenarche (Finding of menstrual bleeding)", + "output": "positive regulation of heart contraction rate by adrenaline-noradrenaline (Molecular Function)" + }, + { + "input": "Definition: Neoplastic Process described as stage IA includes: T1a, N0, M0. T1a: tumor limited to one tube, without penetrating the serosal surface; no ascites. N0: no regional lymph node metastasis. M0: no distant metastasis.\nConcepts: CONC A RECEPT (Amino Acid, Peptide, or Protein)\tmaintenance of dense core vesicle location (maintenance of secretory granule location)\tMilliliter/meter2 (Unit of volume per unit area)\tUrinary tract infection (Infections and Infestations, CTCAE)\tStage IA Fallopian Tube Cancer AJCC v7 (Stage I Fallopian Tube Cancer)", + "output": "Stage IA Fallopian Tube Cancer AJCC v7 (Stage I Fallopian Tube Cancer)" + }, + { + "input": "Definition: something described as a regimen consisting of cisplatin, mitomycin and vinblastine used to treat advanced-stage non-small cell lung cancer.\nConcepts: Abnormal protein O-linked glycosylation (Abnormal protein glycosylation)\teggshell chorion formation (cellular component assembly involved in morphogenesis)\tWD6D3 3 (Intellectual Product)\tCisplatin/Mitomycin/Vinblastine (Therapeutic or Preventive Procedure)\tWorst Severity Past Seven Days Nosebleeds (Clinical or Research Assessment Question)", + "output": "Cisplatin/Mitomycin/Vinblastine (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the activation of natural killer cell-mediated cytotoxicity.\nConcepts: Dihydroorotate Dehydrogenase Inhibitor BAY2402234 (Immunologic Factor)\tCD335 (Gene or Genome)\tGlucuronides (Glycosides)\tKPSSTN (Intellectual Product)\tpulmonary sulcus tumor (Lung Neoplasms)", + "output": "CD335 (Gene or Genome)" + }, + { + "input": "Definition: something described as a dosing measurement based on the spray unit.\nConcepts: behavioral response to wounding (Behavior)\trab3 Protein (Enzyme)\tSmall end part of the outermost bone of pinkie finger (Small epiphyses of the 5th finger)\textracellularly glycine-gated chloride channel activity (extracellularly glycine-gated ion channel activity)\tSpray - dosing instruction imperative (Unit dose)", + "output": "Spray - dosing instruction imperative (Unit dose)" + }, + { + "input": "Definition: Signal Transduction Inhibitor described as a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2). This agent also selectively binds to the peripheral benzodiazepine receptor (PBR), a receptor highly expressed in certain tumor cell types cells, inducing cell cycle arrest and apoptosis in PBR-expressing cells. Diazepinomicin can cross the blood-brain barrier (BBB). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62508\" active clinical trials using this agent.\nConcepts: ATPase activity, coupled to movement of substances (Molecular Function)\tAzacitidine-Gemcitabine (Therapeutic or Preventive Procedure)\tOptic nerve chiasma (Brain part)\tOvarian ablation (Therapeutic or Preventive Procedure)\tDiazepinomicin (Organic Chemical)", + "output": "Diazepinomicin (Organic Chemical)" + }, + { + "input": "Definition: Quantitative Concept described as nanomoles per gram.\nConcepts: Micromole/kilogram (moles per unit mass)\tflower structural organisation (developmental process involved in reproduction)\tDiseases, Mannosidase Deficiency (Disorder of carbohydrate metabolism)\tNVTEST (CDISC SDTM Terminology)\tFocal T2 hyperintense thalamic lesion (Finding)", + "output": "Micromole/kilogram (moles per unit mass)" + }, + { + "input": "Definition: something described as st. George's Respiratory Questionnaire Past 3 Months Version - These are questions about other effects that your respiratory problems may have on you these days: I get afraid or panic when I cannot catch my breath.\nConcepts: ADL03-Usual Dressing Performance (ADCS-ADL MCI Questionnaire Question)\tExternal Ear Cartilage (Tissue)\tSinks (Manufactured Object)\tSGRQ0127 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tClindamycin phosphate (Antibiotics)", + "output": "SGRQ0127 (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)" + }, + { + "input": "Definition: Measurement of substance described as the determination of the amount of hydrocodone present in a sample.\nConcepts: amrubicin (Organic Chemical)\tHydrocodone (Measurement of substance)\tVirosome Vaccines (Immunologic Factor)\t/min (IU per unit time)\tOrganic compound (Organic Chemical)", + "output": "Hydrocodone (Measurement of substance)" + }, + { + "input": "Definition: Molecular Function described as the removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide.\nConcepts: Pain Interferes with Enjoyment of Life (Findings-Based Question)\tUnfolded Protein Responses (Cell Function)\tET190L1-ARTEMIS (T-cell Receptor-engineered T-cells)\tprotein demalonylation (protein deacylation)\tpositive regulation of tumor necrosis factor-alpha production (regulation of tumor necrosis factor production)", + "output": "protein demalonylation (protein deacylation)" + }, + { + "input": "Definition: Neoplastic Process described as the most frequent form of cutaneous mastocytosis. In children, the lesions tend to be papular, and are characterized by aggregates of elongated or spindle-shaped mast cells which fill the papillary dermis and extend into the reticular dermis. In adults, the lesions tend to have fewer mast cells compared to those in children. The lesions are located most commonly on the trunk, but they can be seen on the extremities, head and neck. (WHO, 2001) -- 2003 Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C3433\" active clinical trials using this agent.\nConcepts: Psychological distress (Caregiver emotional health status)\tAIDS-Related Kaposi Sarcoma I1 (Finding)\tpigmentosa urticaria (Skin lesion)\tbis(4-Aminophenyl) Ether (Organic Chemical)\tCatheters, Conduction, Anesthetic (Medical Device)", + "output": "pigmentosa urticaria (Skin lesion)" + }, + { + "input": "Definition: Restrictive Cardiomyopathy, CTCAE described as refractory heart failure or other poorly controlled cardiac symptoms\nConcepts: unit/mL (Arbitrary Unit of Substance Rate)\tSynov sarcoma-epithelioid cell (Monophasic Synovial Sarcoma)\tThin corpus callosum (Congenital hypoplasia of cerebrum)\tASSOC LEARNING (Mental association)\tGrade 4 Restrictive Cardiomyopathy, CTCAE (Restrictive Cardiomyopathy, CTCAE)", + "output": "Grade 4 Restrictive Cardiomyopathy, CTCAE (Restrictive Cardiomyopathy, CTCAE)" + }, + { + "input": "Definition: Anesthesia/Respiratory Equipment and Supplies described as curved devices that fit over the teeth to protect them from damage during endotracheal intubation.\nConcepts: MPAI107A (MPAI-4 Questionnaire Question)\ttwin (Natural sibling)\tCobblestone lissencephaly without muscular or ocular involvement (Cobblestone Lissencephaly)\tProtectors, Teeth (Anesthesia/Respiratory Equipment and Supplies)\tFluorescence Microscopes (Medical Device)", + "output": "Protectors, Teeth (Anesthesia/Respiratory Equipment and Supplies)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Severe human suffering: Not sure.\nConcepts: MSQOL-54 - Feel Tired (Intellectual Product)\tenzyme active site formation via 1'-phospho-L-histidine (peptidyl-histidine phosphorylation)\tPercent Predicted Functional Residual Capacity (Pulmonary function tests)\tLEC-5 Standard Version - Severe Human Suffering: Not Sure (Intellectual Product)\tStudySiteRelationship (Relationships)", + "output": "LEC-5 Standard Version - Severe Human Suffering: Not Sure (Intellectual Product)" + }, + { + "input": "Definition: something described as human PRKCA wild-type allele is located within 17q22-q23.2 and is approximately 508 kb in length. This allele, which encodes protein kinase C alpha type protein, is involved in the phosphorylation of diverse protein substrates in response to activation by calcium or the second messenger diacylglycerol. The PRKCA gene is overexpressed in certain types of cancer such as breast tumors, glioblastomas, pituitary tumors and thyroid neoplasms.\nConcepts: regulation of heptadecane synthesis (Molecular Function)\tfatty acyl-CoA:ecdysone acyltransferase activity (O-acyltransferase activity)\tIMMUNOGLOBULIN A DEFICIENCY 1 (Rare Non-Neoplastic Disorder)\tPKCA (Gene or Genome)\tMarathi language (Language)", + "output": "PKCA (Gene or Genome)" + }, + { + "input": "Definition: Autosomal recessive idiopathic familial dystonia described as autosomal recessive dopa responsive dystonia (DYT5b) is a very rare neurometabolic disorder with a spectrum of symptoms ranging from those seen in dopa responsive dystonia to progressive infantile encephalopathy. Disease presents in infancy (most frequently in the first year of life) with a progressive hypokinetic rigid syndrome, involuntary jerky movements, postural tremor, or gait disturbances that may fluctuate during the day and show good or excellent responsiveness to levodopa in most cases. DYT5b is caused by mutations in the tyrosine hydroxylase TH gene (11p15.5). Inherited in an autosomal recessive manner.\nConcepts: Arbuscular Mycorrhizae (Fungus)\tsquamous cell carcinoma anal (Skin carcinoma)\tMigraine due to oestrogen contraceptive (Migraine Disorders)\tselectins (Calcium-dependent adhesion molecule)\tDystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia, Autosomal Recessive (Autosomal recessive idiopathic familial dystonia)", + "output": "Dystonia, Dopa-Responsive, With Or Without Hyperphenylalaninemia, Autosomal Recessive (Autosomal recessive idiopathic familial dystonia)" + }, + { + "input": "Definition: phosphatidylinositol phosphate binding described as interacting selectively and non-covalently with phosphatidylinositol-4-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' position.\nConcepts: Twenty-One to Forty Active Hours (Finding)\tphosphatidylinositol-4-phosphate binding (Molecular Function)\tVDCC, Q-Type (Biologically Active Substance)\tSEMINAL VESICLES (Seminal Vesicles)\tmeningiomas (Neoplastic Process)", + "output": "phosphatidylinositol-4-phosphate binding (Molecular Function)" + }, + { + "input": "Definition: Hematopoiesis described as the process of generating white blood cells (LEUKOCYTES) from the pluripotent HEMATOPOIETIC STEM CELLS of the BONE MARROW. There are two significant pathways to generate various types of leukocytes: MYELOPOIESIS, in which leukocytes in the blood are derived from MYELOID STEM CELLS, and LYMPHOPOIESIS, in which leukocytes of the lymphatic system (LYMPHOCYTES) are generated from lymphoid stem cells.\nConcepts: Assistive Devices (Medical Device)\tLeukopoiesis (Hematopoiesis)\tBarrett's esophagus with high grade dysplasia (Barrett Esophagus)\tpositive regulation of pancreatic alpha cell differentiation (Cell Function)\tBag, NOS (Device Component or Accessory)", + "output": "Leukopoiesis (Hematopoiesis)" + }, + { + "input": "Definition: something described as a finding indicating decreased tissue sensitivity to a hormone.\nConcepts: SDH1 (Gene or Genome)\thormone resistance (HORMONES, VITAMINS AND RECEPTOR SITES)\tPancreaticobiliary Malunion (Gastrointestinal disorder congenital)\tMOL CYTOGENET TECHNICS (Molecular Biology Research Technique)\tDoes Skin in Treatment Area Itch (Intellectual Product)", + "output": "hormone resistance (HORMONES, VITAMINS AND RECEPTOR SITES)" + }, + { + "input": "Definition: health care personnel education described as instruction or training which precedes and prepares for the study of medicine.\nConcepts: Increased neutrophil mitochondria (Abnormality of neutrophil morphology)\tLugano Classification Advanced Stage Adult Hodgkin Lymphoma AJCC v8 (Lugano Classification Advanced Stage Hodgkin Lymphoma AJCC v8)\tregulation of 17-methylnonadec-1-ene metabolic process (regulation of olefin metabolic process)\tMedical Propedeutics (Educational Activity)\tZone of circumflex branch of left coronary artery (Zone of left coronary artery)", + "output": "Medical Propedeutics (Educational Activity)" + }, + { + "input": "Definition: Miscellaneous Drugs described as a sterile hemostatic agent composed of purified porcine-derived gelatin. In regional chemotherapy, absorbable gelatin sponge may be used to embolize arteries in the region of a tumor in order to block or retard blood flow; this blockage results in a locally increased concentration of chemotherapeutic agents delivered to the tumor when chemotherapeutic agents are infused into the embolized arterial circulation upstream of the blockage.\nConcepts: Infection caused by Cryptosporidium (Protozoan Infections, Animal)\tStage IIIC Prostate Carcinoma AJCC v8 (Neoplastic Process)\tplant ovule morphogenesis (post-embryonic plant morphogenesis)\tAbsorbable gelatin sponge (Medical Device)\tC-SSRS Baseline/Screening Version - Number of Actual Suicide Attempts (C-SSRS Baseline/Screening Version Questionnaire Question)", + "output": "Absorbable gelatin sponge (Medical Device)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as signal transducer and activator of transcription 5A (794 aa, ~91 kDa) is encoded by the human STAT5A gene. This protein is involved in transcriptional regulation, signal transduction and the metabolism of amino acids, carbohydrates and purines.\nConcepts: signal transducer and activator of transcription 5A protein, human (Biologically Active Substance)\tNT3 (NTF3 gene)\tCarcinoma of the Eyelid Pathologic Primary Tumor TNM Finding v7 (Carcinoma of the Eyelid Pathologic TNM Finding v7)\tsyncytiotrophoblasts (trophoblast)\tGAGE7 (Biologically Active Substance)", + "output": "signal transducer and activator of transcription 5A protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Autotransfusion Units described as autotransfusion units designed to collect and process blood lost by a patient to obtain red blood cells for subsequent reinfusion into the same patient (i.e., autotransfusion). These units typically include a disposable suction system to collect blood from the surgical field, a reservoir to store the blood, a spinning processing chamber (e.g., centrifugation device) to separate waste (e.g., clotting factors, debris) and wash the red blood cells with saline, particulate microfilters, and a reinfusion bag that stores the red blood cells suspended in saline. Blood processing autotransfusion units are used mainly during surgical procedures, but they may be also used during postoperative recovery and in emergency or intensive care units after trauma.\nConcepts: HAQ01-Cut Your Meat (Intellectual Product)\tPump Speed, Increased (Finding)\tCytosine-Specific DNA Methylase (Enzyme)\tRed Blood Cell Washing Autotransfusion Units (Medical Device)\tCytochrome aa>3< (Enzyme)", + "output": "Red Blood Cell Washing Autotransfusion Units (Medical Device)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (R)-3-hydroxybehenoyl-CoA(4-) + NADP(3-) <=> 3-oxodocosanoyl-CoA + NADPH + H+.\nConcepts: NRAS NP 002515.1:p.Gly13Ser (Cell or Molecular Dysfunction)\tPhenolphtaleine (Organic Chemical)\tDisorder of sclera, unspecified (Korean Standard Classification of Disease Version 5)\tPepsinogen I (Pepsinogens)\t3-oxo-behenoyl-CoA reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "3-oxo-behenoyl-CoA reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Adenocarcinoma of large intestine described as a rare, invasive colorectal adenocarcinoma characterized by the presence of a malignant infiltrate with serrated glandular architecture.\nConcepts: regulation of cell division (regulation of cellular process)\tUmbilical hernia gangrenous (Bacterial infections NEC)\tfilipinos (Mongol Chinese)\tColorectal Serrated Adenocarcinoma (Adenocarcinoma of large intestine)\tContractor - occupation (Professional or Occupational Group)", + "output": "Colorectal Serrated Adenocarcinoma (Adenocarcinoma of large intestine)" + }, + { + "input": "Definition: Biologically Active Substance described as calmodulin (149 aa, ~17 kDa) is encoded by the human CALM1, CALM2 and CALM3 genes. This protein plays a role in the regulation of a number of enzymes, ion channels and signaling pathways.\nConcepts: DENT PROPHYLAXIS (Periodontic specialty)\tCALM2 (Amino Acid, Peptide, or Protein)\tBrevibacillus laterosporus (Bacterium)\tpurine ribonucleoside triphosphate binding (nucleoside phosphate binding)\tmonosialoganglioside sialyltransferase activity (sialyltransferase activity)", + "output": "CALM2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT Version 4) I have tremors.\nConcepts: FAC06145 (Intellectual Product)\tAnticipatory Vomiting (Anticipatory Nausea and Vomiting)\tClear Cell Variant Thyroid Gland Papillary Carcinoma (Neoplastic Process)\tKA - Keratoacanthoma (Hyperkeratosis)\tGrade 3 Neonatal Culture Positive Sepsis, Adverse Event (Neonatal Culture Positive Sepsis, Adverse Event)", + "output": "FAC06145 (Intellectual Product)" + }, + { + "input": "Definition: North and central Asian country described as the country is bordered by RUSSIA on the north and CHINA on the west, south, and east. The capita is Ulaanbaatar.\nConcepts: TNFRSF13A (Gene or Genome)\tBCR downstream signaling 1 (Gene or Genome)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Bottle, Broth (Medical Device)\tmaturation of LSU-rRNA (rRNA processing)\tMNG (Country)", + "output": "MNG (Country)" + }, + { + "input": "Definition: Ureaplasma described as any bacterial organism that can be assigned to the species Ureaplasma urealyticum.\nConcepts: p110alpha E545X (Cell or Molecular Dysfunction)\tHispanic or Latino (Ethnic group)\tUreaplasma urealyticum biovar 2 (Ureaplasma sp.)\tCongenital anaemia (ENDOCRINE, METABOLIC AND HEMATOLOGIC DISORDERS SPECIFIC TO THE FETUS OR NEWBORN)\tTranslation Initiation Abnormality (Protein Sequence Abnormality)", + "output": "Ureaplasma urealyticum biovar 2 (Ureaplasma sp.)" + }, + { + "input": "Definition: something described as any method of quantitative or qualitative analysis that involves optics and/or the measurement of light.\nConcepts: dprxn mgmt asistnce ndvdl ea (mental health counseling)\tMedicine, Traditional (Anthropological Culture)\tOptical Methods (Laboratory Procedure)\tCorneal stromal opacity (Corneal stroma finding)\tHypohidrosis, CTCAE (Skin and Subcutaneous Tissue Disorders, CTCAE)", + "output": "Optical Methods (Laboratory Procedure)" + }, + { + "input": "Definition: EGFR Exon 18 Mutation described as a deletion of a guanine at position 2156 from the coding sequence of the EGFR gene.\nConcepts: EGFR c.2156delG (Cell or Molecular Dysfunction)\torganophosphate breakdown (Molecular Function)\tChromogenic in Situ Hybridization (Molecular Biology Research Technique)\tActivated B-Lymphocyte (Cell)\tpostsynaptic membrane organisation (membrane organization)", + "output": "EGFR c.2156delG (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as this gene is involved in both cell motility and signal transduction.\nConcepts: RAC1 (G Protein Gene)\tESRS-A - Dystonia: Hips/Lower Limbs/Feet (ESRS-A Clinical Classification Question)\tJapanese Pharmacopeia (Intellectual Product)\tcuracin B (Pharmacologic Substance)\tAnomaly of the zygomatic bone (Deformity of facial bone)", + "output": "RAC1 (G Protein Gene)" + }, + { + "input": "Definition: Homeopathic remedies letter C described as cayenne pepper.\nConcepts: 15q14 microdeletion syndrome (Anomaly of chromosome pair 15)\tcapsicum minimum/cayenne pep (Organic Chemical)\tpositive regulation of symbiont penetration hypha formation for entry into host (positive regulation by symbiont of entry into host)\tTRAM-dependent toll-like receptor signaling pathway (Molecular Function)\tYour change in taste at its worst (Intellectual Product)", + "output": "capsicum minimum/cayenne pep (Organic Chemical)" + }, + { + "input": "Definition: something described as the determination of the ratio of CD4 T cells compared to lymphocytes present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: KIAA0160 (SUZ12 gene)\tpancreatic E cell differentiation (Cell Differentiation process)\tCarotid artery dilatation (Anatomical Abnormality)\tCD4 T Cell to Lymphocyte Ratio Measurement (Laboratory Procedure)\tTilt (Characteristics)", + "output": "CD4 T Cell to Lymphocyte Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Tephritoidea described as a large family of fruit flies in the order DIPTERA, comprising over 4,500 species in about 100 genera. They have patterned wings and brightly colored bodies and are found predominantly in the tropical latitudes.\nConcepts: KIAA0744 protein, human (Amino Acid, Peptide, or Protein)\tTRANSFERRIN, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tPrior Evaluation: Tests Performed (ACC-AHA Measure)\tfruit fly (Eukaryote)\testablishment of episomal latency (establishment of viral latency)", + "output": "fruit fly (Eukaryote)" + }, + { + "input": "Definition: Nuclear Proteins described as c-FOS protein is a transcription factor critical in regulating the development of the skeleton. c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family. Each protein contains a bZIP domain and a leucine zipper domain. FOS oncoproteins derive from mutated FOS genes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein.\nConcepts: Proto-Oncogene Proteins c-fos (Amino Acid, Peptide, or Protein)\tMedical Device Brand Name Family (Family Collection)\tAcne, erythematosa (Erythema)\tEmbolism Protection Devices (Medical Device)\tmeningioma atypical (Grade II Meningioma)", + "output": "Proto-Oncogene Proteins c-fos (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: tryptamine + reduced acceptor + O(2) <=> 4-hydroxytryptamine + acceptor + H(2)O.\nConcepts: Neurotrophic Tyrosine Kinase, Receptor, Type 3 Gene Mutation (Cell or Molecular Dysfunction)\tLittle's disease (Congenital Abnormality)\tAngiotensinogen wt Allele (AGT gene)\tMuscle Physiology, Contractile (Physiology)\ttryptamine 4-monooxygenase activity (Molecular Function)", + "output": "tryptamine 4-monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Organic Chemical described as a proprietary, orally bioavailable, nanoparticle-based encochleated formulation composed of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, encochleated within lipid-based crystals, which are composed of multi-layered, rolled-up sheets of soy-derived phosphatidylserine (PS) bilayers and calcium, with broad-spectrum antifungal activity. Upon oral administration, the cochleate crystal structure protects amphotericin B from degradation within the gastrointestinal (GI) tract. The lipid structure facilitates uptake into the bloodstream where the nanoparticles are taken up by macrophages and fungal cells though phagocytosis. Amphotericin B is released from the cochleate due to the calcium differential between the inside of the cell, which has low calcium levels, and the outside of the cell, which has high calcium levels. This delivers amphotericin B directly to the fungal-infected site and to its target cells. In turn, amphotericin B binds to ergosterol, an essential component of the fungal cell membrane. This results in depolarization of the cell membrane, alterations in cell membrane permeability, leakage of important intracellular components, and cell rupture. This causes fungal cell death and prevents fungal infections. Compared to amphotericin B alone, which can only be administered intravenously (IV), this formulation permits oral administration and reduces treatment-limiting side effects that are seen with IV amphotericin B, particularly nephro- and hepato-toxicity.\nConcepts: cochleate-amphotericin B (Antibiotic)\tBreast Cancer cM1 TNM Finding v7 (Breast Cancer Clinical Distant Metastasis TNM Finding v7)\tIRE binding (mRNA binding)\tcopper; deficiency (Disorder of copper metabolism)\tacquired pure red cell aplasia (Pure Red-Cell Aplasia)", + "output": "cochleate-amphotericin B (Antibiotic)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of a glomerular mesangial cell in the kidney over time, from its formation to the mature structure.\nConcepts: Lifetime Risk (Quantitative Concept)\tglomerular mesangial cell development (epithelial cell development)\tgigantism was noted (Bone Diseases, Developmental)\tNambudripad Allergy Elimination Technique (NAET)(TM) allergy treatment each treatment (Allergy treatment)\tNCI CTEP Simple Disease Classification Clear Cell Sarcoma of the Kidney Sub-Category Terminology (NCI CTEP SDC Kidney Neoplasm Category Terminology)", + "output": "glomerular mesangial cell development (epithelial cell development)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as managing pressure points on a patient's body part, region or full body to prevent and/or minimize his or her risk of a pressure ulcer(s) or bed sore(s).\nConcepts: Multipotent Bone Marrow Stem Cell (Bone Marrow Stem Cell with Variable Lineage Potential)\t7S RNA binding (RNA Binding)\tPAC - Pressure area care (Common nursing interventions)\tIs your appetite poor or reduced from normal (Intellectual Product)\tGroup A streptococcus (Lancefield group streptococcus)", + "output": "PAC - Pressure area care (Common nursing interventions)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) During the past week, how often have you: thought clearly about work?\nConcepts: MLL2 Gene Mutation (Gene Mutant)\tNo shortness of breath (Clinical or Research Assessment Answer)\tQLES131 (Q-LES-Q Questionnaire Question)\tSDTM-PFTEST (Intellectual Product)\tRAS-Like Protein TC21 (RAS Superfamily Proteins)", + "output": "QLES131 (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: something described as ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.\nConcepts: regulation of interleukin-27 formation (regulation of interleukin-27 production)\tRNA BACT (RNA)\tbody composition (Metabolic Phenomena)\tSleep-wake inversion (Sleep-wake cycle disturbance)\tBacteroides ruminicola ss. ruminicola (Prevotella ruminicola)", + "output": "RNA BACT (RNA)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the leukotriene E4 in a biological specimen.\nConcepts: Anal Cancer Clinical Distant Metastasis TNM Finding v8 (Finding)\tCompleted 4th Grade (Finding)\tLeukotriene E4 Measurement (Fatty acid measurement)\tPrognostic Stage III Breast Cancer AJCC v8 (Neoplastic Process)\ttrophectoderm cellular morphogenesis (Cell Function)", + "output": "Leukotriene E4 Measurement (Fatty acid measurement)" + }, + { + "input": "Definition: Undergarment described as a barrier garment or padding used to absorb urine and stool, thereby helping to protect the skin and keep clothing and bedding clean.\nConcepts: FAC008-I Like the Appearance of My Body (Intellectual Product)\tDIAPERS (Personal care and protection device)\tFree part of upper limb (Upper Extremity)\tPlastic operations on nose (rhinologic surgery)\tinfection; Klebsiella (Immunology)", + "output": "DIAPERS (Personal care and protection device)" + }, + { + "input": "Definition: Allogeneic Lymphocyte described as genetically engineered human allogeneic T lymphocytes that are transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo and introduction into the patient, the allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR specifically target and bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is expressed in normal testis and on the surface of various tumor cell types. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C150511\" active clinical trials using this agent.\nConcepts: modulation by symbiont of host inflammatory response (Organism Function)\treplication of extrachromosomal circular DNA during replicative cell aging (replication of extrachromosomal circular DNA)\tUterine Corpus Carcinoma pM1 TNM Finding v7 (Finding)\tallogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR (Allogeneic Lymphocyte)\tOceanic Ancestry Groups (Continental Population Groups)", + "output": "allogeneic T lymphocytes expressing NY-ESO-1-C259-specific TCR (Allogeneic Lymphocyte)" + }, + { + "input": "Definition: something described as organ region cluster, each instance of which is a part of wall of some middle ear that is demarcated by either bona fide or fiat boundaries.\nConcepts: Parkinsonism co-occurrent with dementia of Guadeloupe (Mental or Behavioral Dysfunction)\tanti-Gram-negative bacterial peptide induction (Molecular Function)\tTSCC0128 (TSCC Questionnaire Question)\tHaemorrhage oesophageal (Blood in stool)\tRegion of wall of middle ear (Body Location or Region)", + "output": "Region of wall of middle ear (Body Location or Region)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of vascular endothelial growth factor C present in a sample.\nConcepts: RegulatoryAssessment.typeCode (Type Code)\tALDEHYDE FUCHSIN (Indicator, Reagent, or Diagnostic Aid)\tFLT4 Ligand Measurement (Protein or Enzyme Type Measurement)\tregulation of protein ubiquitination (Molecular Function)\tHaddad Syndrome (Disease or Syndrome)", + "output": "FLT4 Ligand Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Intellectual Product described as modified Hachinski Ischemic Scale-NACC Version (MHIS-NACC) Abrupt onset (re: cognitive status).\nConcepts: SIQ02TN (Intellectual Product)\tBrazilian Paw Paw (Plant)\tIntrasynovial (Musculoskeletal route)\tResidue, Pesticide (Pesticides)\tMHIS01-Abrupt Onset (Intellectual Product)", + "output": "MHIS01-Abrupt Onset (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a rare, extranodal T-cell non-Hodgkin lymphoma that arises from the stomach with the bulk of the mass located in the stomach.\nConcepts: Keratitis, CTCAE (Finding)\tC11orf95-RELA Fusion Protein Expression (Cell or Molecular Dysfunction)\tPrimary T-Cell Lymphoma of Stomach (T-Cell Lymphoma)\tAneurysm of unspecified site (Aneurysm)\tdiseases terminal (disease stage)", + "output": "Primary T-Cell Lymphoma of Stomach (T-Cell Lymphoma)" + }, + { + "input": "Definition: viral process described as the aggregation, arrangement and bonding together of a set of components to form a virus baseplate.\nConcepts: Sm Core Proteins (Immunologic Factor)\tchannel activator activity (channel regulator activity)\tL-4-chlorokynurenine (Amino Acid, Peptide, or Protein)\tEBV positive diffuse large B-cell lymphoma of the elderly (Diffuse large B-cell lymphoma - category)\tvirus baseplate assembly (Physiologic Function)", + "output": "virus baseplate assembly (Physiologic Function)" + }, + { + "input": "Definition: something described as automated cytometers in which cells are dispersed in fluid suspension and flow one at a time through a narrow beam of light, typically from a laser. Each cell generates optical signals that are measured and analyzed. These cytometers include a cell transportation system, a laser for cell illumination, photodetectors for signal detection, and a computer-based management system.\nConcepts: Flow Cytometers (Instrument - device)\tMicrococcus pelletieri (Bacterium)\tbinging (Eating Disorder Self-Control)\tposterodorsal intraculminate fissure (Body Space or Junction)\tmissing data (Data)", + "output": "Flow Cytometers (Instrument - device)" + }, + { + "input": "Definition: ECG voltage described as an electrocardiographic finding of a QRS amplitude less than or equal to 0.5 mV in the limb leads or QRS amplitude less than or equal to 1 mV in the precordial leads.\nConcepts: Benign adenoma (Neoplasms benign site unspecified NEC)\tMicroRNA Gene (Gene or Genome)\tCorneal Trauma (Injury of cornea)\tQS-NCCN-FACT FOSI-18 Version 2 TESTCD (CDISC Questionnaire Terminology)\tDecreased QRS voltage (Abnormal QRS voltage)", + "output": "Decreased QRS voltage (Abnormal QRS voltage)" + }, + { + "input": "Definition: PANCREATIC AND GASTROINTESTINAL HORMONES described as hormones secreted by the gastrointestinal mucosa that affect the timing or the quality of secretion of digestive enzymes, and regulate the motor activity of the digestive system organs.\nConcepts: glucuronate biosynthesis (monocarboxylic acid biosynthetic process)\tgastrointestinal hormone (PANCREATIC AND GASTROINTESTINAL HORMONES)\tColorectal Angiosarcoma (Colorectal Sarcoma)\t4-011 ECTODERMAL DYSPLASIAS (Skin lesion)\ttearing (Injury or Poisoning)", + "output": "gastrointestinal hormone (PANCREATIC AND GASTROINTESTINAL HORMONES)" + }, + { + "input": "Definition: something described as carious lesion of pit and fissure origin in occlusal areas and buccal or lingual pits.\nConcepts: Pit and fissure caries (Disease or Syndrome)\tBhutan (Indian subcontinent country)\tregulation of dorsal/ventral axon pathfinding (Cell Function)\tOfloxacin (Quinolone Antibiotic)\tMIHG1 (MicroRNA Gene)", + "output": "Pit and fissure caries (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as a series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).\nConcepts: Aspergillus, NOS (Aspergillaceae)\tHPP (Disease or Syndrome)\tintrinsic apoptotic pathway (intracellular signal transduction)\tNanoparticle Characterization (Research Activity)\tNasolacrimal sac lymphoma (Abnormal lacrimal sac morphology)", + "output": "intrinsic apoptotic pathway (intracellular signal transduction)" + }, + { + "input": "Definition: something described as an abnormally increased degree of bleeding following a superfical injury to the surface of the skin.\nConcepts: Periocular capillary hemangioma (Strawberry nevus of skin)\tregulation of starch breakdown (Molecular Function)\tElevated LDH (Laboratory or Test Result)\tExcessive bleeding from superficial cuts (Pathologic Function)\tDISTAL FEMUR R1 (Body Location or Region)", + "output": "Excessive bleeding from superficial cuts (Pathologic Function)" + }, + { + "input": "Definition: something described as human HOXA7 wild-type allele is located in the vicinity of 7p15.2 and is approximately 4 kb in length. This allele, which encodes homeobox protein Hox-A7, plays a role in anterior-posterior regulation of gene expression during embryonic development.\nConcepts: Focal impaired awareness cognitive seizure with forced thinking (Disease or Syndrome)\t177Lu Human Monoclonal Antibody 5B1 (Indicator, Reagent, or Diagnostic Aid)\tDifferentiating (Neuroblastoma)\tHOX1 (Gene or Genome)\tPIROMIDIC ACID (Anti-Infective Agents, Urinary)", + "output": "HOX1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a polyunsaturated long-chain fatty acid with an 18-carbon backbone and exactly two double bonds, originating from the 10th and 12th positions from the methyl end, resulting in a conjugated section of the acyl chain. Three stereoisomers of conjugated linoleic acid, n-6 are recognized.\nConcepts: Oriental herb and/or natural substance preparation training individual each 15 minutes (Therapeutic or Preventive Procedure)\tFatigue, Auditory (Auditory Threshold)\tHead proper (Body Part, Organ, or Organ Component)\t10,12 Conjugated Linoleic Acid (Organic Chemical)\tWHODAS 2.0 36-item Version Proxy-administered - Standing Up From Sitting Down (Intellectual Product)", + "output": "10,12 Conjugated Linoleic Acid (Organic Chemical)" + }, + { + "input": "Definition: Pituitary carcinoma described as a rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces thyrotropin.\nConcepts: Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary (Thyroid stimulating hormone-producing pituitary tumor)\tIntergroup Rhabdomyosarcoma Clinical Grouping System (Intellectual Product)\tregulation of phagocytosis, engulfment (Cell Function)\tCompressors, External Vascular (Compressors)\tPurinergic Receptor P2Y, G-Protein Coupled, 2 Gene (Gene or Genome)", + "output": "Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary (Thyroid stimulating hormone-producing pituitary tumor)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported - If you answered \"sometimes\" or \"never or rarely\" to Question 57 above, was your activity limited by: Pain?\nConcepts: Melanoma of the Ciliary Body and Choroid pTX TNM Finding v7 (Melanoma of the Ciliary Body and Choroid Pathologic Primary Tumor TNM Finding v7)\tecdysiostatic hormone activity (neuropeptide hormone activity)\tLEC01-Transportation Accident: Not Apply (Intellectual Product)\tNADPH:cytochrome c reductase activity (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)\tPODCI358 (PODCI Adolescent Self-Reported Version Questionnaire Question)", + "output": "PODCI358 (PODCI Adolescent Self-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: AP-type membrane coat adaptor complex described as a membrane coat adaptor complex that links clathrin to a membrane.\nConcepts: PlannedCriterionGroupCompositionRelationship (Qualitative Concept)\tGM-CSF biosynthesis (cytokine biosynthesis)\tclathrin adaptor complex (Cell Component)\tCDISC Clinical Classification HAM-D6 Clinician Version Test Name Terminology (Intellectual Product)\tIGGCREAT (Laboratory Procedure)", + "output": "clathrin adaptor complex (Cell Component)" + }, + { + "input": "Definition: Findings-Based Question described as a question about whether an individual is or was dissatisfied with their body.\nConcepts: Subjects, Human (Investigative Subject)\tBregma (Sutural junction)\tHave Been Dissatisfied with Body (Intellectual Product)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Connective Tissue, Antinuclear Antibody (Medical Device)\tBone structure of shaft of humerus (Humerus part)", + "output": "Have Been Dissatisfied with Body (Intellectual Product)" + }, + { + "input": "Definition: Cerebrovascular Disorders described as an autoimmune microvascular disease that is characterized by the clinical triad of encephalopathy, branch retinal artery occlusions, and hearing loss.\nConcepts: HAPTOGLOBIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tDexamethasone/Elotuzumab/Pomalidomide (Therapeutic or Preventive Procedure)\tZone 1 of the Lliver Acinus (Digestive System Part)\tGrade 1 Skin hypopigmentation (Skin Hypopigmentation, CTCAE 5)\tSusac syndrome (Disease or Syndrome)", + "output": "Susac syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Eukaryote described as a genus of SPONGES in the family Petrosiidae, characterized by an ectosomal triangular or polygonal reticulation of spicule tracts or single spicules.\nConcepts: Head, NOS (Body Location or Region)\tHealth Care Policy (Health services, systems and policies)\tpositive regulation of insulin secretion in response to glucose (positive regulation of response to stimulus)\tPetrosia (Porifera)\tEnd of Life Problem Identified (Finding)", + "output": "Petrosia (Porifera)" + }, + { + "input": "Definition: G Protein Gene described as this gene plays a role in protein sorting and GTPase activity.\nConcepts: Acid Sensing Ion Channel (Biologically Active Substance)\tCeliac Plexus Neurolysis (Therapeutic or Preventive Procedure)\tbiological signal transduction (Cell physiology)\tAbnormal platelet aggregation (Platelet analyses)\tADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 (Gene or Genome)", + "output": "ADP-RIBOSYLATION FACTOR-RELATED PROTEIN 1 (Gene or Genome)" + }, + { + "input": "Definition: Action described as the process of increasing by addition (as to a collection or group).\nConcepts: Gastric Neuroendocrine Tumor cM1 TNM Finding v8 (Finding)\tAccession Action (Action)\tScanning Systems, Ultrasonic, Small-Parts (Medical Device)\tCementocyte (Dental pulp cell)\tPCBSPPD (Mass Measurement)", + "output": "Accession Action (Action)" + }, + { + "input": "Definition: Hyperaldosteronism described as primary hyperaldosteronism caused by an aldosterone-secreting adenoma.\nConcepts: Cables/Leads, Apnea Monitors (Cables/Leads)\tconns syndrome (Endocrine Syndrome)\tRenal hypomagnesaemia type 3 (Manz syndrome)\tOrganic Oxide (Chemical Viewed Functionally)\tStructure of infratemporal fossa (Head)", + "output": "conns syndrome (Endocrine Syndrome)" + }, + { + "input": "Definition: something described as human MAML1 wild-type allele is located in the vicinity of 5q35 and is approximately 64 kb in length. This allele, which encodes mastermind-like protein 1, plays a role in the modulation of notch signaling-dependent transcription.\nConcepts: methaqualone (Quinazolinones)\tMacroscopic Findings Biospecimen Usability (Biospecimen Usability)\tPerformed Substance Administration Dose Period Code (Intellectual Product)\tezetimibe (Dietary Cholesterol Absorption Inhibitor [EPC])\tMastermind-Like 1 (Drosophila) wt Allele (MAML1 gene)", + "output": "Mastermind-Like 1 (Drosophila) wt Allele (MAML1 gene)" + }, + { + "input": "Definition: something described as a synthetic analogue of retinoic acid with differentiation inducing and potential antineoplastic activities. Like other retinoic acid agents, namirotene binds to and activates retinoic acid receptors (RARs), thereby altering the expression of certain genes leading to cell differentiation and decreased cell proliferation in susceptible cells.\nConcepts: breast cancer 2, early onset protein, human (DNA repair protein)\tPost-Basic Nursing Education (Education, Nursing)\tNAMIROTENE (Pharmacologic Substance)\tEpendymoma (Ependymoma)\tPentacyclic Triterpenes (Organic Chemical)", + "output": "NAMIROTENE (Pharmacologic Substance)" + }, + { + "input": "Definition: Information Resources described as the Cancer Information Service is the National Cancer Institute's link to the public, interpreting and explaining research findings in a clear and understandable manner, and providing personalized responses to specific questions about cancer. Access the CIS by calling 1-800-4-CANCER (1-800-422-6237), or by using the LiveHelp instant-messaging service at https://cissecure.nci.nih.gov/livehelp/welcome.asp.\nConcepts: MNSI - Hurt When Bed Covers Touch Skin (MNSI Questionnaire Question)\tD1FATSCD (CDISC SDTM Terminology)\tLacrimal Bone (Entire cranial bone)\tCancer Information Service (Intellectual Product)\tpeptidyl-citrulline synthesis from peptidyl-arginine (peptidyl-arginine modification)", + "output": "Cancer Information Service (Intellectual Product)" + }, + { + "input": "Definition: Leishmania donovani complex described as an isolate that is genetically identical to Leishmania infantum. It is the etiologic agent of LEISHMANIASIS, VISCERAL in the Americas.\nConcepts: Pilonidal sinus/cyst NOS (Cyst)\tchagasi, Leishmania chagasi (Blood and tissue flagellate)\tPlum pox potyvirus (Potyvirus)\tOxiplex/AP Gel (Topical Preparation)\tCSS11-Preparatory Acts/Behavior, Descr (C-SSRS Lifetime/Recent Version Questionnaire Question)", + "output": "chagasi, Leishmania chagasi (Blood and tissue flagellate)" + }, + { + "input": "Definition: Finding described as failing to produce an effect from some foregoing stimulus or agent.\nConcepts: FSS - Fatigue Interferes With Work (FSS Questionnaire Question)\tPersonal Health Screening Behavior (Health behavior outcomes)\tADNI AVLT - List A Recall 3 Word 10 (Intellectual Product)\tMedical School (Schools, Health Occupations)\tUnresponsive (General Qualifier)", + "output": "Unresponsive (General Qualifier)" + }, + { + "input": "Definition: Neoplastic Process described as an anaplastic oligoastrocytoma that occurs during childhood.\nConcepts: Anaplastic Oligoastrocytoma (Childhood Mixed Glioma)\tBiopsy of nose (Diagnostic procedures on nose)\tcarbon C-14 dacomitinib (Organic Chemical)\tavailableForEvaluationIndicator (Indicator)\tAZATHIOPRINE SODIUM (Purine antagonist)", + "output": "Anaplastic Oligoastrocytoma (Childhood Mixed Glioma)" + }, + { + "input": "Definition: Pharmacologic Substance described as a fully human monoclonal antibody directed against the membrane-bound receptor HER3 (ERBB3) with potential antineoplastic activity. Patritumab binds to and inhibits HER3 activation, which may result in inhibition of HER3-dependent PI3K/Akt signaling and so inhibition of cellular proliferation and differentiation. HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, is frequently overexpressed in solid tumors, including breast, lung, and colorectal tumors of epithelial origin; it has no active kinase domain itself but is activated through heterodimerization with other members of the EGFR receptor family that do.\nConcepts: patritumab (Monoclonal Antibodies)\tK+ facilitation of cell motility (cell motility)\tCornish Cross Chicken (Bird)\tPoikilotherms (Animals)\tGrade 2 Spermatic cord obstruction (Spermatic Cord Obstruction, CTCAE 3.0)", + "output": "patritumab (Monoclonal Antibodies)" + }, + { + "input": "Definition: Abnormality of the parathyroid gland described as a functional abnormality of the parathyroid gland.\nConcepts: positive regulation of activated CD8-positive, alpha-beta T-lymphocyte apoptosis (regulation of activated CD8-positive, alpha-beta T cell apoptotic process)\tAbsent salivary secretion (Ear, nose and throat finding)\tFibrobacter species (Fibrobacteraceae)\tEvaluates continuity of care (Behavioral Responses: Patient and Family - Knowledge/Psychosocial)\tParathyroid dysfunction (Abnormality of the parathyroid gland)", + "output": "Parathyroid dysfunction (Abnormality of the parathyroid gland)" + }, + { + "input": "Definition: Metastatic Esophageal Carcinoma described as esophageal carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment.\nConcepts: Evidence of Disease Present after Completion of Therapy (Finding)\tGrade 1 Bronchospasm, CTCAE (Finding)\tprotein uridylylation (Molecular Function)\tblack plum (Food)\tAdvanced Esophageal Carcinoma (Neoplastic Process)", + "output": "Advanced Esophageal Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Body Space or Junction described as a small, pyramidal space located between the pterygoid process, the maxilla, and the palatine bone.\nConcepts: Syringomas, Chondroid (Benign neoplasm of oral cavity)\tWD5-Care of Household Responsibilities (Intellectual Product)\tBody temperature decreased (Nursing Assessment Entity)\tSphenomaxillary Fossa (Fossa)\tCPNIGMAB (Chlamydia pneumoniae antibody test)", + "output": "Sphenomaxillary Fossa (Fossa)" + }, + { + "input": "Definition: Allogeneic Tumor Cell Vaccine described as a whole cell vaccine comprised of irradiated allogeneic renal cell carcinoma (RCC) with potential immunostimulating and antineoplastic activities. Allogeneic renal cell carcinoma vaccine MGN1601 contains two active ingredients: 1) genetically modified allogeneic RCC cells that are transiently transfected with four different MIDGE (Minimalistic Immunogenically Defined Gene Expression) vectors encoding IL-7, GM-CSF, CD80 and CD154 and 2) the synthetic DNA-based immunomodulator dSLIM-30L1, a TLR9 agonist. Vaccination results in expression of IL-7, GM-CSF, CD80 and CD154, which all contribute to the activation or enhancement of immune responses. Furthermore, administration of this RCC vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate immunity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95213\" active clinical trials using this agent.\nConcepts: Metaphyseal cupping of proximal phalanges (Hand)\tInfectious Bovine Rhinotracheitis (Rhinitis)\tGrade 1 Voice Alteration, CTCAE (Voice Alteration, CTCAE)\tallogeneic renal cell carcinoma vaccine MGN1601 (Pharmacologic Substance)\tNina, La (Natural Phenomenon or Process)", + "output": "allogeneic renal cell carcinoma vaccine MGN1601 (Pharmacologic Substance)" + }, + { + "input": "Definition: Medical Device described as dental prostheses designed to fit into a prepared dental cavity (i.e., inlays) to restore one tooth. Inlays are precision fitted and cemented to the surrounded intact tooth so that the patient cannot remove them. These prostheses (i.e., intracoronal restorations) are typically custom-made devices made of cast metal alloys (e.g., medium-hard gold), synthetic (e.g., acrylic) resins, or ceramics. Inlays are used to restore tooth contours and function; they are not intended to anchor fixed partial dental prostheses.\nConcepts: Economic services, systems and policies (Occupational Activity)\tOnlays (Dental Prosthesis)\tUterine Corpus Atypical Polypoid Adenomyoma (Neoplastic Process)\tACETYL COENZYME A (Coenzymes)\tMi-2b Gene Mutation (Gene Mutant)", + "output": "Onlays (Dental Prosthesis)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the gamma-aminobutyric acid in a biological specimen.\nConcepts: post-embryonic foregut morphogenesis (post-embryonic animal morphogenesis)\tGamma-Aminobutyric Acid Measurement (Amino acids measurement)\tadaptive immune effector response (Organism Function)\tMaxillary Sinus Carcinoma pT4a TNM Finding v8 (Finding)\tTegmental Nucleus, Pedunculopontine (Nucleus of basal part of pons)", + "output": "Gamma-Aminobutyric Acid Measurement (Amino acids measurement)" + }, + { + "input": "Definition: Imidazole antifungal described as an antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes.\nConcepts: Product containing miconazole (Imidazole derivatives, antimycotic for systemic use)\tCytochrome P450, Family 1, Subfamily A, Polypeptide 2*11 Allele (Gene or Genome)\tEyelid Ptoses (Deformity)\tDimethylglycine dehydrogenase (Oxidoreductase)\tplacenta development (reproductive structure development)", + "output": "Product containing miconazole (Imidazole derivatives, antimycotic for systemic use)" + }, + { + "input": "Definition: Finding described as maxillary sinus cancer with tumor causing bone erosion or destruction including extension into the hard palate and/or middle nasal meatus, except extension to posterior wall of maxillary sinus and pterygoid plates.\nConcepts: Maxillary Sinus Carcinoma pT2 TNM Finding v8 (Finding)\tTNFSF13 Gene (Gene or Genome)\tA treatment plan cannot succeed if it is in conflict with a patient's lifestyle or values (Clinical or Research Assessment Question)\tSERA, REACTIVE AND NON-SPECIFIC CONTROL, FTA-ABS TEST (Indicator, Reagent, or Diagnostic Aid)\tPTAP1-Minimum Interval Tone All (Paced Tapping Functional Test Question)", + "output": "Maxillary Sinus Carcinoma pT2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: N [Preparations] described as the sulfate salt form of netilimicin, a semisynthetic, water soluble aminoglycoside antibiotic. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. Netilmicin irreversibly binds to the 16S rRNA and S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, netilmicin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.\nConcepts: 1-N-ethyl sisomicin (Organic Chemical)\tclinical study designation (Study Identifier)\tSGRQ01-Playing Sports (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tProtein Fragment (Amino Acid, Peptide, or Protein)\tA2BR Antagonist PBF-1129 (Immunologic Factor)", + "output": "1-N-ethyl sisomicin (Organic Chemical)" + }, + { + "input": "Definition: something described as hypoglycemic Confidence Scale (HCS) How confident are you that you can stay safe from serious problems with hypoglycemia: When you are exercising?\nConcepts: RTN4 protein, human (Regulatory Protein)\tpositive regulation of mesonephric glomerulus development (positive regulation of glomerulus development)\tHCS0101 (Intellectual Product)\tProviding a prepared beverage to supplement energy or nutrient intake. (Source: IDNT Reference Manual, edition 4; ISBN #978-0-88091-467-3). (Medical food supplement therapy)\textranodal (Anatomy Qualifier)", + "output": "HCS0101 (Intellectual Product)" + }, + { + "input": "Definition: Symptom Specific Assessment Tool described as a scale grading dyspnea from 0 (not troubled with breathlessness except with strenuous exercise) to 4 (too breathless to leave the house or breathless when dressing or undressing).\nConcepts: Left ventricular cavity (Body Space or Junction)\tMedical Research Council Dyspnea Scale (Symptom Specific Assessment Tool)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ALDH7A1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, NSD1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tCatheters, Vascular, Angioplasty, Balloon/Ultrasound Image (Medical Device)", + "output": "Medical Research Council Dyspnea Scale (Symptom Specific Assessment Tool)" + }, + { + "input": "Definition: Conceptual Entity described as indicates relative presence or absence. From the enumeration AbsoluteCallTypeEnum (Present / Absent / Marginal / No call) or ComparisonCallTypeEnum (Increase / Marginal Increase / Decrease / Marginal Decrease / No change / No Call / Unknown), as specified by the dataType.\nConcepts: Present/Absent (Indicator)\tFIBROBLAST GROWTH FACTOR 23 (Fibroblast Growth Factor Gene Family)\tpM0 Cancer of the Bladder TNM Finding (Bladder Cancer Pathologic Distant Metastasis TNM Finding v6)\tKIAA1929 (RHPN1 gene)\tventral region, lateral zone (Body Part, Organ, or Organ Component)", + "output": "Present/Absent (Indicator)" + }, + { + "input": "Definition: CRS-R Clinical Classification Question described as JFK Coma Recovery Scale-Revised - Oromotor/verbal function scale.\nConcepts: CRSR0108 (Intellectual Product)\tHg (Heavy metal screen)\tStatistical Confidence (Qualitative Concept)\tALPHA-1-AGP (Gene or Genome)\tNasal Cavity and Paranasal Sinuses Carcinoma cN2c TNM Finding v8 (Finding)", + "output": "CRSR0108 (Intellectual Product)" + }, + { + "input": "Definition: Bacterium described as a species of aerobic, Gram negative, rod and cocci shaped bacteria assigned to the phylum Proteobacteria. This species is catalase and oxidase positive, penicillin susceptible, urease positive and salt tolerant. P. immobilis exhibits low virulence and is pathogenic only in rare cases.\nConcepts: Medullary Thyroid Carcinoma pT4 TNM Finding v8 (Finding)\tHeart Chamber Volume, End Ventricular Systole (Finding)\tPsychrobacter immobilis Juni and Heym 1986 (Bacterium)\taflatoxin metabolic process (mycotoxin metabolic process)\tTS inhibitor DFP-11207 (Thymidylate synthase inhibitor)", + "output": "Psychrobacter immobilis Juni and Heym 1986 (Bacterium)" + }, + { + "input": "Definition: Chemical injury described as burns caused by contact with or exposure to CAUSTICS or strong ACIDS.\nConcepts: Striae gravidarum (Linear atrophy)\tNEDD4-1 (Gene or Genome)\tBioactive substance intake (Nutrient intake - finding)\tallatostatin receptor activity (G protein-coupled peptide receptor activity)\tburning chemicals (Burn injury)", + "output": "burning chemicals (Burn injury)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of mannan catabolic process.\nConcepts: Maldrin (Pharmacologic Substance)\tpositive aerotaxis (positive energy taxis)\tdownregulation of cardiac chamber morphogenesis (negative regulation of animal organ morphogenesis)\tnegative regulation of mannan degradation (negative regulation of cellodextrin metabolic process)\t3,5-dibromo-N-(4-bromophenyl)-2-hydroxybenzamide (Topical anti-infective)", + "output": "negative regulation of mannan degradation (negative regulation of cellodextrin metabolic process)" + }, + { + "input": "Definition: Benzamide structure-containing product described as an orally bioavailable chlorinated salicylanilide, with anthelmintic and potential antineoplastic activity. Upon oral administration, niclosamide specifically induces degradation of the androgen receptor (AR) variant V7 (AR-V7) through the proteasome-mediated pathway. This downregulates the expression of the AR variant, inhibits AR-V7-mediated transcriptional activity, and reduces AR-V7 recruitment to the prostate-specific antigen (PSA) gene promoter. Niclosamide also prevents AR-V7-mediated STAT3 phosphorylation and activation. This inhibits AR/STAT3-mediated signaling and prevents expression of STAT3 target genes. Altogether, this may inhibit growth of AR-V7-overexpressing cancer cells. The AR-V7 variant, which is encoded by contiguous splicing of AR exons 1/2/3/CE3, is upregulated in a variety of cancer cell types, and is associated with both cancer progression and resistance to AR-targeted therapies.\nConcepts: Benzamide, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy- (Benzamide structure-containing product)\tgastroenteritis nos (Gastric and gastroenteric infections)\tdownregulation of GTP binding (regulation of GTP binding)\tEPIC1-Problem Pain/Burning on Urination (Intellectual Product)\tDAD01-Plan & Org Num Applic Items (DAD Questionnaire Question)", + "output": "Benzamide, 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxy- (Benzamide structure-containing product)" + }, + { + "input": "Definition: Negative Regulation of Cell Differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.\nConcepts: Frequency that Fatigue Limits Work (Clinical or Research Assessment Question)\tnegative regulation of stalk cell differentiation (Cell Function)\tAcute Myeloid Leukemia with Non-Germline Mutated RUNX1 (Neoplastic Process)\tC-SSRS Children's Baseline - Suicidal Behavior (Intellectual Product)\tSpringing Treatment (Osteopathic manipulation)", + "output": "negative regulation of stalk cell differentiation (Cell Function)" + }, + { + "input": "Definition: something described as a series of the vessels that transport deoxygenated blood.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SDHB (Medical Device)\tComponent of oligomeric golgi complex 1 congenital disorder of glycosylation (Autosomal recessive hereditary disorder)\tvenous system (Body System)\tPhysicians; Physician/Osteopath; Surgical Critical Care: Surgery (Physicians; Physician/Osteopath)\tjaw (Organ region cluster)", + "output": "venous system (Body System)" + }, + { + "input": "Definition: Charcot-Marie-Tooth disease type 4 described as charcot-Marie-Tooth disease, type 4B1 (CMT4B1) is a severe early-onset demyelinating CMT peripheral sensorimotor polyneuropathy. It was initially described in an Italian family and around 10 additional families have been described so far. Onset occurs during early childhood with distal and proximal muscular weakness starting in the lower extremities, sensory loss and cranial nerve involvement. Foot deformities are frequent and diaphragmatic and facial involvement has been reported. CMT4B1 is caused by mutations in the gene encoding myotubularin-related protein 2 (MTMR2; 11q22), involved in polyphosphoinositide signaling. Transmitted in an autosomal recessive manner.\nConcepts: Cell Division Control Protein 6 Homolog (Licensing Factor)\tCMT4B (Charcot-Marie-Tooth disease type 4)\tIsoimmunization of Newborn with Rhesus Anti-D Antibody (Disease or Syndrome)\tacetate metabolic process (Molecular Function)\tAbsent ankle pulse (Finding)", + "output": "CMT4B (Charcot-Marie-Tooth disease type 4)" + }, + { + "input": "Definition: Laboratory Procedure described as a procedure used to detect and identify rearrangements involving the BRAF gene.\nConcepts: B-RAF1 Gene Rearrangement Analysis (Laboratory Procedure)\tABBV-181 (Immunologic Factor)\tStructure of crista terminalis cordis (Region of wall of right atrium)\tGenes, WT1 Wilms Tumor (Gene or Genome)\tPQL17-Hard Tell Doctors/Nurses How Feel (Intellectual Product)", + "output": "B-RAF1 Gene Rearrangement Analysis (Laboratory Procedure)" + }, + { + "input": "Definition: Criminal Offenses described as biased behaviors or attitudes, differential treatment, unequal access to social participation or opportunities based on age.\nConcepts: age discrimination (Legal Issues)\tMedical Device Optical Issue (Device physical property issue)\tSalivary Gland Acinic Cell Neoplasm (Malignant neoplasm of mouth)\tPeptidic growth factors deficiency (Lipodystrophy)\tRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding (intronic transcription regulatory region sequence-specific DNA binding)", + "output": "age discrimination (Legal Issues)" + }, + { + "input": "Definition: Occupation or Discipline described as a technique for growing plants in culture solutions rather than in soil. The roots are immersed in an aerated solution containing the correct proportions of essential mineral salts.\nConcepts: Hydroponic (Agriculture)\tSodium ferric gluconate complex (Iron and iron compound)\tdown regulation of photoreceptor differentiation (negative regulation of neuron differentiation)\tbursa-equivalent lymphocyte (Cell)\tdiets (Nutrition function)", + "output": "Hydroponic (Agriculture)" + }, + { + "input": "Definition: Retractors, Surgical described as surgical retractors designed to temporarily separate and hold back the edges of an incision performed on the skin, exposing and providing access to subcutaneous tissues and/or other superficial anatomic structures. These retractors usually consist of slender, handheld, manual instruments with a hook- or fork-like curved blade at the distal tip and an integral flat or tubular handle. Skin surgical retractors are used for cosmetic (plastic surgery) and/or therapeutic surgical procedures performed under the skin.\nConcepts: Have Low Self-Esteem due to Swallowing Problem (Findings-Based Question)\tCorynebacterium amycolatum (Bacterium)\tVena subcostalis sinistra (Structure of hemiazygous vein)\tSuperior anterior superior pancreaticoduodenal lymph nodes (Set of visceral abdominal lymph nodes)\tSkin retractor, device (Retractor, device)", + "output": "Skin retractor, device (Retractor, device)" + }, + { + "input": "Definition: something described as columbia-Suicidality Severity Rating Scale Children's Baseline/Screening (C-SSRS Children's Baseline/Screening) Initial/first attempt actual lethality/medical damage.\nConcepts: gland sebaceous (Simple branched acinar gland)\tBROSTALLICIN (DNA Minor Groove Binding Agent)\tTumor of Lip (Oral cavity neoplasms NEC)\tCSS07-First Attempt Damage (Intellectual Product)\tnegative regulation of telomere capping (Genetic Function)", + "output": "CSS07-First Attempt Damage (Intellectual Product)" + }, + { + "input": "Definition: Symptom aggravating factors described as applied to a sign or symptom that is worsened by taking contraceptive medication. []\nConcepts: protein O-mannosyltransferase complex location (mannosyltransferase complex)\tFollowing [Ambiguous] (Beginning)\tContraceptive pills aggravate symptoms (Finding)\tNHS II-PAQ (Clinical or Research Assessment Questionnaire)\tbeta-catenin destruction complex disassembly (protein-containing complex disassembly)", + "output": "Contraceptive pills aggravate symptoms (Finding)" + }, + { + "input": "Definition: Volume of Distribution for Dosing Interval described as the volume of distribution associated with the terminal slope following extravascular administration divided by the fraction of dose absorbed, calculated using AUCTAU, divided by the weight.\nConcepts: Readministration (Therapeutic or Preventive Procedure)\tVz for Dose Int by F Norm by WT (Volume of Distribution for Dosing Interval)\tUnknown Procedure Type for New Tumor Event (CPTAC Responses)\tIntrusive Thought (Disturbance in thinking)\tCell parts set (Postnatal anatomical structure)", + "output": "Vz for Dose Int by F Norm by WT (Volume of Distribution for Dosing Interval)" + }, + { + "input": "Definition: something described as a rare complex type of hereditary spastic paraplegia with characteristics of adult-onset spastic paraplegia associated with spinal pain that radiates to the upper or lower limbs and is related to disk herniation (with minor spondylosis), as well as mild sensorimotor neuropathy. The phenotype has been mapped to a locus on chromosome 6q23-q24.1.\nConcepts: pesticide resistance (Biologic Function)\tConsultation NOS (Information Management)\tAutosomal recessive spastic paraplegia disc herniation syndrome (Complicated hereditary spastic paraplegia)\tOrganization identifier (Intellectual Product)\tSickle Cell Solubility Test (Hematologic Tests)", + "output": "Autosomal recessive spastic paraplegia disc herniation syndrome (Complicated hereditary spastic paraplegia)" + }, + { + "input": "Definition: Cyclooxygenase Inhibitors described as the gel form of a drug that is used to treat the symptoms of rheumatoid arthritis and is being studied in the prevention and treatment of some types of skin cancer. It blocks substances that cause inflammation and pain. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of cyclooxygenase inhibitor, a type of nonsteroidal anti-inflammatory drug (NSAID), and a type of antiangiogenesis agent.\nConcepts: Follistatin wt Allele (FST gene)\tductal tubular breast carcinoma (Breast and nipple neoplasms malignant)\tdiclofenac sodium gel (Cyclooxygenase Inhibitors)\tbenzaldehyde dehydrogenase (NADP+) activity (Molecular Function)\tGR17 (GPR17 gene)", + "output": "diclofenac sodium gel (Cyclooxygenase Inhibitors)" + }, + { + "input": "Definition: Protein Family described as a family of glycoproteins expressed on the surface of various human antigen-presenting cells. They are related to the class I MHC molecules, and are involved in the presentation of lipid antigens to T-cells. The family is separated into group 1, expressed on cells specialized for antigen presentation, and group 2, expressed on a wider variety of cells.\nConcepts: CD1 (Protein Family)\tpositive regulation of histone H2A-H2B dimer displacement (Cell Function)\tProduct Dose (Conceptual Entity)\tOwn car (Transportation)\tNeuroblastoma RAS Viral (v-ras) Oncogene Homolog c.183A>T (Cell or Molecular Dysfunction)", + "output": "CD1 (Protein Family)" + }, + { + "input": "Definition: something described as a closure that shows the package has been opened and the product has been exposed to the outside environment.\nConcepts: metamorphopsia (Visual Acuity)\tDesign (Action)\tDyskinesia Syndromes (Central Nervous System)\tTamper-evident, Plastic (Container Closure System)\tCYTOGENETIC MINOR RESPONSE (Finding)", + "output": "Tamper-evident, Plastic (Container Closure System)" + }, + { + "input": "Definition: Brucellaceae described as a species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath.\nConcepts: Appendix Neuroendocrine Tumor pM1c TNM Finding v8 (Appendix Neuroendocrine Tumor pM1 TNM Finding v8)\tT1-DDS - Subscale 3: Hypoglycemia Distress (T1-DDS Questionnaire Question)\tIVD Test Reagent/Kits, Clinical Chemistry, Control, Serum, Abnormal (IVD Test Reagent/Kits, Clinical Chemistry, Control, Serum)\tBacterium tussis-convulsivae (Bordetella species)\tGreat Pyrenee dog (Mammal)", + "output": "Bacterium tussis-convulsivae (Bordetella species)" + }, + { + "input": "Definition: Medical Device described as a projecting part of a device that allows it to be secured through an opening.\nConcepts: Analyzers, Physiologic, Extracellular Limb Fluid, Electrical Impedance (Analyzers, Physiologic)\tpurine ribonucleotide interconversion (purine nucleotide interconversion)\tConnector Pin (Medical Device)\thumanized monoclonal antibody (Amino Acid, Peptide, or Protein)\tMUC2 gene (Gene or Genome)", + "output": "Connector Pin (Medical Device)" + }, + { + "input": "Definition: something described as human TSKS wild type allele is located in the vicinity of 19q13.3 and is approximately 24 kb in length. This allele, which encodes testis-specific serine kinase substrate protein, may play a role in testicular physiology.\nConcepts: Floating anatomical plane (Spatial Concept)\tVulvar Basal Cell Carcinoma (Dermatosis of external genitalia)\tIDO1 Inhibitor PF-06840003 (Pharmacologic Substance)\tEsophagus and Esophagogastric Junction Cancer cM1 TNM Finding v7 (Esophagus and Esophagogastric Junction Cancer Clinical Distant Metastasis TNM Finding v7)\tTestis-Specific Kinase Substrate Gene (Gene or Genome)", + "output": "Testis-Specific Kinase Substrate Gene (Gene or Genome)" + }, + { + "input": "Definition: Myelodysplastic syndrome, no ICD-O subtype described as myelodysplastic syndrome, unclassifiable characterized by persistent cytopenia (s) with 1 percent or fewer blasts in the blood and fewer than 5% in the bone marrow, unequivocal dysplasia in less than 10 percent of the cells in one or more myeloid lineages, and cytogenetic abnormalities considered as presumptive evidence of myelodysplastic syndrome.\nConcepts: C165939 (Immunoglobulin E measurement)\tMyelodysplastic Syndrome, Unclassifiable, Based on Defining Cytogenetic Abnormality (Neoplastic Process)\tlong-chain fatty-acyl-CoA synthesis (Molecular Function)\tSB-AS02B adjuvant (Pharmacologic Substance)\tmimulus cardinalis/scarlet m (Pharmacologic Substance)", + "output": "Myelodysplastic Syndrome, Unclassifiable, Based on Defining Cytogenetic Abnormality (Neoplastic Process)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the regulated release of dopamine.\nConcepts: PTPRK Gene (Gene or Genome)\tGrade 4 Blurred Vision, CTCAE (Finding)\tMaxillary Sinus Cancer TNM Finding v6 (Nasal Cavity and Paranasal Sinus Cancer TNM Finding v6)\tLate-onset proximal muscle weakness (MUSCLE SOFT, TISSUE)\tregulation of dopamine secretion (regulation of cell communication)", + "output": "regulation of dopamine secretion (regulation of cell communication)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA.\nConcepts: External Cardiac Pacemaker Electrodes, Transcutaneous (Medical Device)\tPapillary, Follicular, Hurthle Cell, Poorly Differentiated, and Anaplastic Thyroid Carcinoma pT2 TNM Finding v8 (Finding)\tCell cavity (Body Space or Junction)\turacil breakdown (pyrimidine nucleobase catabolic process)\tFlood Source (Instrument - device)", + "output": "uracil breakdown (pyrimidine nucleobase catabolic process)" + }, + { + "input": "Definition: Disease or Syndrome described as this syndrome has characteristics of the association of microencephaly, agenesis of the corpus callosum, brainstem hypoplasia, cystic cerebellum and fetal akinesia sequence. Less than 10 cases have been described so far. The syndrome is transmitted as an autosomal recessive trait and may be an allelic variant of Neu-Laxova syndrome and lissencephaly type III with metacarpal bone dysplasia.\nConcepts: ATPase, Cu++ Transporting, Alpha Polypeptide wt Allele (Gene or Genome)\tLissencephaly type 3 familial foetal akinesia sequence syndrome (Hereditary disorder of nervous system)\t2:1 AV BLOCK (Atrioventricular Block)\tregulation of cytotoxic T-lymphocyte degranulation (regulation of T cell mediated cytotoxicity)\tserpin family protein binding (Molecular Function)", + "output": "Lissencephaly type 3 familial foetal akinesia sequence syndrome (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgery performed with the purpose of replacing a degenerated, calcified, malformed, dysfunctional, etc. cardiac valve with a bioprosthetic, homograft, or autograft valve.\nConcepts: Coxa Magna (Disease or Syndrome)\tSODIUM CHLORIDE SOL HYPERTONIC (Electrolyte Replacement Agent)\tValve Replacement (Cardiac Valve Procedure)\tUridine Phosphates (Ribonucleotides)\tNIPPLE (Female breast)", + "output": "Valve Replacement (Cardiac Valve Procedure)" + }, + { + "input": "Definition: something described as emotion Recognition - Total number of stimuli (face images) expected to be administered in the task.\nConcepts: pN1 Uterine Carcinoma TNM Finding v6 (Finding)\tEMO101 (ERT Functional Test Question)\tTemperature Sensor Device (sensor)\tS-Acetyltransferase, Dihydrolipoamide (Enzyme)\tNav1.1 (Gene Mutation)", + "output": "EMO101 (ERT Functional Test Question)" + }, + { + "input": "Definition: modulation by virus of host cellular process described as any process in which a virus effects a change in the organization of chromatin in the host.\nConcepts: regulation by virus of host chromatin organization (regulation of chromatin organization)\tATP transmembrane transporter activity (organic anion transmembrane transporter activity)\tHER2Bi-Armed ATCs (Antineoplastic Immune Cell)\t3-methoxy-5-hydroxytoluene O-methyltransferase activity (methyltransferase activity)\tethylene mediated signaling pathway (ethylene-activated signaling pathway)", + "output": "regulation by virus of host chromatin organization (regulation of chromatin organization)" + }, + { + "input": "Definition: Tick-Borne Diseases described as severe fever with thrombocytopenia syndrome (SFTS) is a newly emerging infectious disease.\nConcepts: NCPDP MeasurementUnitCode Terminology (Intellectual Product)\t6q27 (Chromosome band)\tPericardial excision (Thorax excision)\tVirus Infection, SFTS (Disease or Syndrome)\tAlbers-Schonberg Disease (Bone Diseases, Developmental)", + "output": "Virus Infection, SFTS (Disease or Syndrome)" + }, + { + "input": "Definition: regulation of humoral immune response described as any process that activates or increases the frequency, rate, or extent of a humoral immune response.\nConcepts: Pegylated Paclitaxel (paclitaxel)\tteicoplanin (Anti-Bacterial Agents)\tregulation of beta-catenin-TCF complex assembly (Cell Function)\tupregulation of humoral immune response (Organism Function)\tActinobacteraeota Oren et al. 2015 (Terrabacteria group)", + "output": "upregulation of humoral immune response (Organism Function)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving mycolic acids, beta-hydroxy fatty acids with a long alpha-alkyl side chain.\nConcepts: Connective and Soft Tissue Finding (Finding)\t6p25-p23 (Cell Component)\tLIS (carbon-oxygen lyase activity, acting on phosphates)\tGyrus olfactorius lateralis (Body Part, Organ, or Organ Component)\tmycolate metabolic process (Fatty Acid Metabolism Pathway)", + "output": "mycolate metabolic process (Fatty Acid Metabolism Pathway)" + }, + { + "input": "Definition: something described as the process in which a cell switches from monopolar cell growth to bipolar cell growth.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Listeria Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)\tcis-Golgi to rough ER vesicle-mediated transport (Cell Function)\tcell growth mode switching, monopolar to bipolar (Cell Function)\tAbsent/small calf bone (Finding)\tSynthesized Drugs (Pharmacologic Substance)", + "output": "cell growth mode switching, monopolar to bipolar (Cell Function)" + }, + { + "input": "Definition: Dental Restoration, Permanent described as dental prostheses designed to restore the posterior teeth by fitting around the remains of a tooth and covering one or more of the mesial, occlusal, and distal surfaces; they are precision fitted and cemented to the surrounded tooth so that the patient cannot remove them. Onlays usually cover the entire occlusal surface of a tooth to include the cusps, differentiating them from inlays. These prostheses (i.e., extracoronal restorations) are typically custom-made devices made of cast metal alloys (e.g., medium-hard gold), synthetic (e.g., acrylic) resins, or ceramic (e.g., porcelain). Onlays are used mainly to restore posterior tooth contours and function.\nConcepts: WHODAS 2.0 36-item Version Interviewer-administered - Learning a New Task (Intellectual Product)\tConversion, Gene (Homologous Recombination)\tPQL0310 (Intellectual Product)\tinlay (Prostheses, Dental, Fixed)\tCombined immunity defic (Certain disorders involving the immune mechanism)", + "output": "inlay (Prostheses, Dental, Fixed)" + }, + { + "input": "Definition: something described as quick Inventory of Depressive Symptomatology - Self-Report - Please circle the one response to each item that best describes you for the past seven days: Sleeping too much.\nConcepts: Research Model, Animal (Study models)\tPragmatic Clinical Trial (Randomized Controlled Trial)\tHBLEPRHB (Laboratory Procedure)\tQIDSR104 (QIDS-SR Questionnaire Question)\tSLE-System lupus erythematosus (Korean Standard Classification of Disease Version 5)", + "output": "QIDSR104 (QIDS-SR Questionnaire Question)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as despite the non-specific name it generally refers to Factor XIIIa. A few citations use the term nonspecifically with respect to the state of activation.\nConcepts: SFV - Semliki Forest virus (Alphavirus)\tBorderline Ovarian Endometrioid Cystadenofibroma (Cystadenofibroma)\tTransglutaminase, Plasma (Amino Acid, Peptide, or Protein)\tdendrite repulsion (neuron recognition)\tEndosome Proton (Cell Component)", + "output": "Transglutaminase, Plasma (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a claudin subtype that takes part in maintaining the barrier-forming property of TIGHT JUNCTIONS. Claudin-4 is found associated with CLAUDIN-8 in the KIDNEY COLLECTING DUCT where it may play a role in paracellular chloride ion reabsorption.\nConcepts: claudin 4 (Claudins)\tstele development (Histogenic Process)\tLight Sources, Rigid Endoscope/Multipurpose, Handheld Instrument, Direct Attachment (Medical Device)\tTherapy, Oxygen Inhalation (Administration of substance)\tCEDS (Disease or Syndrome)", + "output": "claudin 4 (Claudins)" + }, + { + "input": "Definition: something described as stage III includes: (T1, N2, M0); (T2a, N2, M0); (T2b, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0). T3: Tumor involves bony structures and/or paranasal sinuses. N2: Bilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa. M0: No distant metastasis. (AJCC 6th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C7396\" active clinical trials using this agent.\nConcepts: area Iam (area 10 of Walker)\tlipase activator activity (enzyme activator activity)\tStage III Nasopharynx Carcinoma AJCC v6 (Stage III Pharynx Carcinoma)\tAlopecia, progressive neurological defect, endocrinopathy syndrome (Autosomal recessive hereditary disorder)\tRetinal vascular disorder (Finding)", + "output": "Stage III Nasopharynx Carcinoma AJCC v6 (Stage III Pharynx Carcinoma)" + }, + { + "input": "Definition: Prostaglandin measurement described as the determination of the amount of the prostaglandin D2 in a sample.\nConcepts: Noni (Tracheophyta)\tComplement Component 2 wt Allele (C2 gene)\tPGD2 measurement (Laboratory Procedure)\tSpinal Cord Infarct During Birth (Infarction of spinal cord)\tBody of ulna (Part of diaphysis of bone)", + "output": "PGD2 measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended for use in identifying exchanges (i.e., translocations) between chromosome 5 band q33 and chromosome 12 band p13, usually involving genes PDGFRB and ETV6, respectively. This translocation is characteristic of myeloproliferative/myelodysplastic syndromes with eosinophilia. Its detection may be used as a tumor marker.\nConcepts: contraceptive sponge (Sponges)\tcaries of smooth surface (Dental caries)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(5;12)(q33;p13) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)\tGrade 2 Rectal Hemorrhage, CTCAE (Finding)\tGemfibrozilum (Peroxisome Proliferator Receptor alpha Agonist)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(5;12)(q33;p13) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)" + }, + { + "input": "Definition: something described as a rare hemangioma that arises from the prostate gland.\nConcepts: Prostate Hemangioma (Neoplastic Process)\tEmbryo CS12 (Embryonic Structure)\tresponse to 2-sulfanylethanol (response to alcohol)\tNeoplasm of vulva (Genital Neoplasms, Female)\thimalaya proselect geriforte (Nutraceuticals)", + "output": "Prostate Hemangioma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a subjective score of 9 on a depression scale that ranges from 0: No Depression to 10: Worst Possible Depression.\nConcepts: Depression Score 9 (Depression Visual Analogue Scale)\tRhodopsins, Sensory (Biologically Active Substance)\tNonprogressive restrictive external ophthalmoplegia (Disease or Syndrome)\tRADIOMETRIC, FE59, IRON BINDING CAPACITY (Indicator, Reagent, or Diagnostic Aid)\tcontent validity (Validity)", + "output": "Depression Score 9 (Depression Visual Analogue Scale)" + }, + { + "input": "Definition: General visual observation described as a symptom describing the inability to comprehend more than one element of a visual picture at a given moment, or to integrate the whole visual picture.\nConcepts: Label Type Flag (Functional Concept)\tInhibitors, P450 CYP2C9 (Cytochrome P-450 Enzyme Inhibitors)\tSimultanagnosia (Finding)\tNon-Neoplastic Salivary Gland Disorder (Disease or Syndrome)\t1-Carboxyglutamic Acid (Biologically Active Substance)", + "output": "Simultanagnosia (Finding)" + }, + { + "input": "Definition: Symptom Status described as severity of signs and symptoms of elevated blood glucose levels\nConcepts: StudySubject (Investigative Subject)\tnegative regulation of smooth muscle cell-matrix adhesion (Negative Regulation of Cell-Matrix Adhesion)\tnegative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation (negative regulation of CD8-positive, alpha-beta T cell extravasation)\tCHROMOSOME 08 (NUCLEUS AND ASSOCIATED STRUCTURES)\tHyperglycemia Severity (Symptom Status)", + "output": "Hyperglycemia Severity (Symptom Status)" + }, + { + "input": "Definition: Cell Function described as the killing by an organism of a cell in its symbiont organism by means of the rupture of cell membranes and the loss of cytoplasm. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.\nConcepts: cytolysis by host of symbiont cells (cytolysis in other organism involved in symbiotic interaction)\thead of the posterior horn (Segment of dorsal gray column of spinal cord)\tantibody diversity (Variation)\tCarboplatin/Gemcitabine/Paclitaxel Regimen (Regimen Used to Treat Non-Small Cell Lung Carcinoma)\ttag term (Intellectual Product)", + "output": "cytolysis by host of symbiont cells (cytolysis in other organism involved in symbiotic interaction)" + }, + { + "input": "Definition: Serology described as family of phosphorylated nonhistone nucleoproteins involved in mitosis; do not confuse with LAMININ, which is an extracellular matrix glycoprotein.\nConcepts: spinocervical tract (Spinothalamic Tracts)\tFatal submersion-immersion (Death and sudden death)\tlamin (Protein Family)\tPupillometer (Ophthalmological equipment)\tMorgue (Health care facility)", + "output": "lamin (Protein Family)" + }, + { + "input": "Definition: hearing impairment described as a condition in which a person partially loses the ability to hear sounds in one or both ears.\nConcepts: somatic dysfunction of hip (Hip joint finding)\tSupratentorial primitive neuroectodermal tumor (Primary malignant neoplasm of brain)\tVentricle (General anatomical term)\tDeafness, partial (Finding)\tAtrial Fibrillation (Finding present on electrocardiogram)", + "output": "Deafness, partial (Finding)" + }, + { + "input": "Definition: Enzymes described as an old term for glycolysis. Often it is used to describe anaerobic glucose catabolism that includes the further conversion of PYRUVIC ACID to LACTIC ACID or ETHANOL.\nConcepts: Performance (Action)\tCASP5 gene (Gene or Genome)\tAutoimmune Addison's Disease (Addison Disease)\tEmbden-Meyerhof pathway, function (Molecular Function)\tantipodal cell degeneration (Cell Function)", + "output": "Embden-Meyerhof pathway, function (Molecular Function)" + }, + { + "input": "Definition: Obstetric procedure described as a surgical or medical procedure that terminates a pregnancy by removing the products of conception.\nConcepts: parvicellular part of the subparafascicular nucleus (Subparafascicular nucleus)\tEnterocytozoon, NOS (Microsporidia )\tnegative regulation of peroxidase reaction (negative regulation of oxidoreductase activity)\tTermination of pregnancy - elective (Unspecified Abortion)\tphenylbutyrate sodium (4-phenylbutyric acid)", + "output": "Termination of pregnancy - elective (Unspecified Abortion)" + }, + { + "input": "Definition: protein activation cascade described as a protein activation cascade that contributes to blood coagulation and consists of the cascade of enzymatic reactions initiated by physical damage to the wall of a blood vessel, leading to the formation of a formation of a fibrin clot at the site of the injury. The process also includes numerous positive and negative regulatory events.\nConcepts: Relative Enzyme Activity (NCI Thesaurus Property)\taffect blunted (Mood finding)\tCollaborates, develops, and implements an individualized plan of care (Behavioral Responses: Patient and Family - Knowledge/Psychosocial)\tinfectious enterocolitis (Intestinal infectious disease)\tblood coagulation, fibrin clot formation (Molecular Function)", + "output": "blood coagulation, fibrin clot formation (Molecular Function)" + }, + { + "input": "Definition: something described as a subtype of von Willebrand disease that results from qualitative deficiencies of VON WILLEBRAND FACTOR. The subtype is divided into several variants with each variant having a distinctive pattern of PLATELET-interaction.\nConcepts: IFNT secretion (type I interferon secretion)\tPhosphorus, homeopathic preparation (Homeopathic remedies letter P)\tVWD, TYPE 2 (Autosomal hereditary disorder)\tPrecipitation - climate (Climate)\tEpinephrine Secreting (Hormonal Change)", + "output": "VWD, TYPE 2 (Autosomal hereditary disorder)" + }, + { + "input": "Definition: Congenital Abnormality described as characterized by the choledochocele dilatation of the distal portion of the COMMON BILE DUCT in the DUODENUM where the pancreatic duct (PANCREATIC DUCTS) enters.\nConcepts: Proliferative Verrucous Leukoplakia (Verrucous oral leukoplakia)\tTurntables, Laboratory (Turntables)\ttube lumen formation (anatomical structure formation involved in morphogenesis)\tTORPOR (Physiologic Thermoregulation)\tType III choledochal cyst (Congenital Abnormality)", + "output": "Type III choledochal cyst (Congenital Abnormality)" + }, + { + "input": "Definition: Intellectual Product described as stent Thrombosis Coronary ARC Grade - A grading system to describe the coronary stent thrombosis per the classification schema described by the Academic Research Consortium.\nConcepts: 16:0 monogalactosyldiacylglycerol desaturase activity (omega-3 fatty acid desaturase activity)\tARC STC Grade - Stent Thrombosis Coronary ARC Grade (ARC STC Grade Clinical Classification Question)\tForkhead-Associated Domain (Amino Acid Sequence)\tDiazepinomicin (Signal Transduction Inhibitor)\tpositive regulation of M-CSF signaling pathway (positive regulation of cytokine-mediated signaling pathway)", + "output": "ARC STC Grade - Stent Thrombosis Coronary ARC Grade (ARC STC Grade Clinical Classification Question)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 478 of the coding sequence of the GNAS gene where cytosine has been mutated to thymine.\nConcepts: Radiometry (Laboratory Procedure)\tPermanent Neonatal Diabetes Mellitus (Disease or Syndrome)\tGSA c.478C>T (GNAS Gene Mutation)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SGCD (Medical Device)\tCesky Terrier (Non-Sporting Breed)", + "output": "GSA c.478C>T (GNAS Gene Mutation)" + }, + { + "input": "Definition: nodal signaling pathway described as a series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves.\nConcepts: Surgical Wound Drain (Medical Device)\tCDK4/6 Inhibitor SHR6390 (Antineoplastic Enzyme Inhibitor)\tBarbarea verna (Plant)\tnodal signaling pathway involved in determination of left/right asymmetry (regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry)\t74 KINGDOM ANIMALIA - PHYLUM PORIFERA (Animals)", + "output": "nodal signaling pathway involved in determination of left/right asymmetry (regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry)" + }, + { + "input": "Definition: something described as the characteristic 3-dimensional shape and arrangement of multimeric proteins (aggregates of more than one polypeptide chain).\nConcepts: Decrease in magnesium content of the diet compared to the assessed baseline intake of magnesium for the individual. (Magnesium modified diet)\tepistomal sclerite morphogenesis (Organ or Tissue Function)\tProtein Structure, Quaternary (Protein Conformation)\tnicotinate nucleotide metabolism (pyridine nucleotide metabolic process)\tFinger Cots (Medical Device)", + "output": "Protein Structure, Quaternary (Protein Conformation)" + }, + { + "input": "Definition: glycosphingolipid biosynthetic process described as the chemical reactions and pathways resulting in the formation of glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group.\nConcepts: PE-1 protein, human (Amino Acid, Peptide, or Protein)\tPerformed Clinical Study Activity (Component of Study Protocol)\tglycosylceramide biosynthetic process (glycosphingolipid biosynthetic process)\tJagdterrier (Mammal)\tPerseveration (Language finding)", + "output": "glycosylceramide biosynthetic process (glycosphingolipid biosynthetic process)" + }, + { + "input": "Definition: Mesh surgical material described as surgical mesh is a metallic or polymeric screen intended to be implanted to reinforce soft tissue or bone where weakness exists. Examples of surgical mesh are metallic and polymeric mesh for hernia repair, and acetabular and cement restrictor mesh used during orthopedic surgery.\nConcepts: melanoma, lentigo maligna malignant (melanoma)\tPlace.name (Name)\tMESH, SURGICAL, POLYMERIC (Medical Device)\tcellular response to cation stress (cellular response to salt stress)\tCyclophilin (Amino Acid, Peptide, or Protein)", + "output": "MESH, SURGICAL, POLYMERIC (Medical Device)" + }, + { + "input": "Definition: something described as any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.\nConcepts: zlib (Intellectual Product)\tPhorbol-12,13-Dibutyrate (Phorbol Esters)\tDU-145 (Experimental Model of Disease)\tregulation of cell growth by sensing of nuclear:cytoplasmic ratio (Cell Function)\tRifaximina (Antibiotics)", + "output": "regulation of cell growth by sensing of nuclear:cytoplasmic ratio (Cell Function)" + }, + { + "input": "Definition: something described as a subdivision of the frontal lobe of the macaque defined on the basis of cytoarchitecture. It is \\\"narrow cortex with a well-developed [internal granular layer] and medium-sized pyramidal cells in the outer part of the fifth layer. The remainder of the fifth and sixth layers are poorly developed.\\\" Walker regarded the most likely cytoarchitectural homologue in the area 10 of Brodmann (human); he did not regard it as a cytoarchitectural homologue of area 10 of Brodmann (guenon) ( Walker-1940 ).\nConcepts: Absent/hypoplastic middle phalanx of 5th finger (Aplasia/Hypoplasia of the phalanges of the 5th finger)\tSubhyaloid heme (Disorder of vitreous body and/or retina)\tWEE1 G2 CHECKPOINT KINASE (Non-Receptor Tyrosine Kinase Gene)\tnegative regulation of amine degradation (negative regulation of cellular catabolic process)\t10 (Body Location or Region)", + "output": "10 (Body Location or Region)" + }, + { + "input": "Definition: something described as uneven (irregular) increase in bone density of one or more of the phalanges of the hand.\nConcepts: Small uterus (Uterine Anomalies)\tUneven increase in bone density in finger bone (Sclerosis of finger phalanx)\tlife support systems (Human-caused Phenomenon or Process)\tTube feeding of patient (gastrointestinal)\tConsent Withdrawn (Finding)", + "output": "Uneven increase in bone density in finger bone (Sclerosis of finger phalanx)" + }, + { + "input": "Definition: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen described as catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+).\nConcepts: AME (Electrolyte imbalance NEC)\tBone Marrow Depression (Bone Marrow Diseases)\tFocal aware orofacial automatism seizure (Focal aware automatism seizure)\tNot Applicable (Package Type)\thomogentisate:oxygen 1,2-oxidoreductase (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)", + "output": "homogentisate:oxygen 1,2-oxidoreductase (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a composite substructure of the pontine tegmentum that includes the motor nucleus of the tegmentum, the median raphe nucleus, the inferior central nucleus, the nucleus papilliformis, the subceruleus nucleus, the locus ceruleus, the lateroventral tegmental nucleus, the dorsal tegmental nucleus and the ventral tegmental nucleus ( Crosby-1962 ). See also pontine tegmentum.\nConcepts: Marrubium vulgare L., 1753 (Plant)\ttegmental gray of the pons (Body Part, Organ, or Organ Component)\tLeukocytapheresis (Operative procedure on vein)\tCRQ-SAS Follow-Up Administration Version - Feel Upset, Worried or Depressed (Intellectual Product)\tProduct.typeCode (Type Code)", + "output": "tegmental gray of the pons (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Biologically Active Substance described as interferon regulatory factor 7 (503 aa, ~54 kDa) is encoded by the human IRF7 gene. This protein plays a role in the cellular response to viral infection.\nConcepts: Focal impaired awareness cognitive seizure with illusion (Disease or Syndrome)\toxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor (Molecular Function)\tInterferon Regulatory Factor 7 (TRANSCRIPTION FACTOR)\tt(1;13) (Chromosomal translocation)\tSevacizumab (Immunologic Factor)", + "output": "Interferon Regulatory Factor 7 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as a human placental lactogen test system is a device intended to measure the hormone human placental lactogen (HPL), (also known as human chorionic somatomammotrophin (HCS)), in maternal serum and maternal plasma. Measurements of human placental lactogen are used in the diagnosis and clinical management of high-risk pregnancies involving fetal distress associated with placental insufficiency. Measurements of HPL are also used in pregnancies complicated by hypertension, proteinuria, edema, post-maturity, placental insufficiency, or possible miscarriage.\nConcepts: Mechanical Hook Prostheses (Medical Device)\tregulation of endothelial cell proliferation (regulation of epithelial cell proliferation)\tPowder for inhalation (Powder dose form)\tpeanut (Plant)\tRADIOIMMUNOASSAY, HUMAN PLACENTAL LACTOGEN (Indicator, Reagent, or Diagnostic Aid)", + "output": "RADIOIMMUNOASSAY, HUMAN PLACENTAL LACTOGEN (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any elsewhere undefined new client, in-office meeting without ICD diagnosis, narrative required. This code may be used by practitioners trained to perform client/patient assessments. Oriental medicine practitioners and acupuncturists may use this code. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: UV-A, blue light phototransduction (Cell Function)\twhite matter disease (imaging studies: nonspecific abnormal findings of central nervous system)\tSciences, Translational Medical (Research Activity)\tMedical Toxicology - Pediatrics - Physicians (Professional or Occupational Group)\tundef.new inofc W/O ICD dx (New client in-office without ICD diagnosis)", + "output": "undef.new inofc W/O ICD dx (New client in-office without ICD diagnosis)" + }, + { + "input": "Definition: something described as the location on the precordium that corresponds to the tricuspid region, between the fifth, and sixth intercostal spaces at the left sternal border; LLSB.\nConcepts: MLL-AF4 Fusion Gene (Fusion Gene)\tActivated Protein C Resistance Measurement (Laboratory Procedure)\tLeft lower sternal border (Heart Sounds)\tregulation of systemic arterial blood pressure by ischemic conditions (Organism Function)\tfiscal rsrce prcrmnt cmunt (health system management)", + "output": "Left lower sternal border (Heart Sounds)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an immunoglobulin fragment composed of one variable domain from an IMMUNOGLOBULIN HEAVY CHAIN from the serum of camelids (ALPACAS, LLAMAS, CAMELS, and DROMEDARY).\nConcepts: Respiratory System, Trachea, Bronchus (Trachea)\tFAC07535 (Intellectual Product)\tRecurrent cutaneous abscess formation (Recurrent abscess formation)\tVHH Antibodies (Immunologic Factor)\tSupraglottic hemangioma (Neoplastic Process)", + "output": "VHH Antibodies (Immunologic Factor)" + }, + { + "input": "Definition: something described as an extensive order of highly specialized insects including bees, wasps, and ants.\nConcepts: CDISC SDTM Musculoskeletal System Finding Test Code Terminology (Intellectual Product)\tCell Culture, Expansion, Flask or Bottle (Laboratory Procedure)\tCSS05-Number of Actual Attempts-Since (C-SSRS Already Enrolled Subjects Questionnaire Question)\tPowdered drug preparation, NOS (SolidDrugForm)\tOrder: Hymenoptera (Insecta)", + "output": "Order: Hymenoptera (Insecta)" + }, + { + "input": "Definition: Viral Genetics described as virus mediated transfer of genetic material between cells; also refers to the transfer of bacterial DNA by phages.\nConcepts: paralysis; cerebral, dyskinetic (Cerebral Palsy)\tGENET TRANSDUCTION (Recombination, Genetic)\tPhosphatidylinositol 3,4,5-Trisphosphate 3-Phosphatase and Dual-Specificity Protein Phosphatase PTEN Deficiency (Finding)\tmammogenesis (Organ or Tissue Function)\tirinotecan-eluting beads (Organic Chemical)", + "output": "GENET TRANSDUCTION (Recombination, Genetic)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a chromosomal abnormality consisting of the presence of one chromosome in addition to the normal diploid number.\nConcepts: Thin split thickness graft of skin (Split thickness graft of skin)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Urinary Bladder (IVD Test Reagent/Kits, Immunoassay, Tumor Marker)\tactivation of MAPKKK cascade involved in cell wall biogenesis (positive regulation of stress-activated MAPK cascade)\tTrisomy (Learning Disorders & Mental Retardation)\tTROCHLEAR NERVE PALSY, FAMILIAL CONGENITAL (Fourth cranial nerve paresis)", + "output": "Trisomy (Learning Disorders & Mental Retardation)" + }, + { + "input": "Definition: Technology, Industry, and Agriculture described as materials or substances such as land, timber, fresh water, fossil fuels, or mineral deposits that occur in a natural state and have economic value or usefulness to humans.\nConcepts: Resources, Natural (Idea or Concept)\tIVD Test Reagent/Kits, Serology, Parasite, Entamoeba histolytica, IgG Antibody (Medical Device)\tbilharzias (Schistosoma)\tAnomaly of chromosome, NOS (Congenital chromosomal disease)\tCuracao (Islands of Netherlands)", + "output": "Resources, Natural (Idea or Concept)" + }, + { + "input": "Definition: plasma lipoprotein particle remodeling described as the acquisition, loss or modification of a protein or lipid within a low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase, with the subsequent loss of free fatty acid, and the transfer of cholesterol esters from LDL to a triglyceride-rich lipoprotein particle by cholesteryl ester transfer protein (CETP), with the simultaneous transfer of triglyceride to LDL.\nConcepts: Interstitial Nephritides (Urologic Diseases)\tRibosomal RNA (RNA)\tClostridium innocuum Smith and King 1962 (Bacterium)\tLDL remodeling (Cell Function)\tparaventricular hypothalamic nucleus, magnocellular division, medial magnocellular part (magnocellular division of the paraventricular nucleus)", + "output": "LDL remodeling (Cell Function)" + }, + { + "input": "Definition: Medical Device described as a ptosis crutch is a device intended to be mounted on the spectacles of a patient who has ptosis (drooping of the upper eyelid as a result of faulty development or paralysis) to hold the upper eyelid open.\nConcepts: 11C-metformin (Radioconjugate)\textra vehicular activity (Space Flight)\tCatheters, Anesthetic Conduction (Medical Device)\tBiologic Entity Identifier with Attribute Identifier (Intellectual Product)\tPtosis crutch (Medical Device)", + "output": "Ptosis crutch (Medical Device)" + }, + { + "input": "Definition: Medical Device described as non-inflatable extremity splint; see product code FYH.\nConcepts: LEC0104E (Intellectual Product)\tSPLINT, EXTERMITY, NON-INFLATABLE, EXTERNAL, NON-STERILE (Medical Device)\tcentral nervous system neuron development (neuron development)\tHypoplastic areolae (Abnormal areolar morphology)\tMitogen (Pharmacologic Substance)", + "output": "SPLINT, EXTERMITY, NON-INFLATABLE, EXTERNAL, NON-STERILE (Medical Device)" + }, + { + "input": "Definition: something described as multipurpose splints designed to be conformed to the appropriate shape (i.e., molded) at the point of care site. These splints typically consist of a thin metallic (e.g., aluminum) and/or thermosetting plastic sheet that can be cut and/or molded according to the body part and the needs of the patient. Moldable splint orthoses are intended mainly for emergency treatment of patients suffering fractures, sprains, dislocations, and/or other injuries of the limbs, neck, and/or other body parts. Dedicated aluminum and plastic multipurpose moldable splints are available.\nConcepts: optic cup formation involved in camera-type eye development (anatomical structure formation involved in morphogenesis)\tOrthoses, Multipurpose Splint, Moldable (Orthoses, Multipurpose Splint)\tPI0101 (Intellectual Product)\tEthiazide (Organic Chemical)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PRPH2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Orthoses, Multipurpose Splint, Moldable (Orthoses, Multipurpose Splint)" + }, + { + "input": "Definition: CDISC SEND Terminology described as terminology associated with the planned pharmacologic target mode of action response codelist of the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND).\nConcepts: 1p32.3 (Chromosome band)\tBenign Intracranial Tumor (Neoplasms, Intracranial)\tPlanned Pharmacologic Target Mode of Action Response (CDISC SEND Terminology)\tGerm cell tumour, NOS (neoplasm/cancer site)\tdulcitol diepoxide (Pharmacologic Substance)", + "output": "Planned Pharmacologic Target Mode of Action Response (CDISC SEND Terminology)" + }, + { + "input": "Definition: fluoride transmembrane transport described as the directed movement of fluoride ions from inside of a cell, across the plasma membrane and into the extracellular region.\nConcepts: IGHER (MS4A2 gene)\tInferior Maxillary Bone (Mandible)\tfluoride export across plasma membrane (export across plasma membrane)\tCytoxan-Oncovin-procarbazine-prednisone/adriamycin-bleomycin-vinblastine regimen (Therapeutic or Preventive Procedure)\tKnives, Surgical, Spinal (scalpel)", + "output": "fluoride export across plasma membrane (export across plasma membrane)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the regulated release of activin from a cell.\nConcepts: Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8 (Stage IV Thyroid Gland Medullary Carcinoma AJCC v8)\t3: 188946177-188921867 (Spatial Concept)\tcellulose catabolism by endo-processive cellulases (cellulose catabolic process)\tregulation of activin secretion (Cell Function)\tProvidencia (Morganellaceae)", + "output": "regulation of activin secretion (Cell Function)" + }, + { + "input": "Definition: Urinary abnormalities described as the presence of mildly increased concentrations of albumin in the urine (in adults, 30-150 mg per day).\nConcepts: regulation of neuronal cell death (Regulation of Cell Death Process)\tmicroalbuminuria (Proteinuria of undiagnosed cause)\tPOLR2L wt Allele (Gene or Genome)\tStimulators, Light (Medical Device)\tHomeobox B13 wt Allele (HOXB13 gene)", + "output": "microalbuminuria (Proteinuria of undiagnosed cause)" + }, + { + "input": "Definition: Neoplastic Process described as a usually aggressive malignant neoplasm arising from the heart. It is characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a herringbone growth pattern.\nConcepts: UPD1-Motor:Tremor at Rest:Feet: Left (Intellectual Product)\tAdverse Event Location Description (Location Description)\tTRINUCLEOTIDE REPEAT-CONTAINING 9 (Transcription factor genes)\tCylinder Device (Device Component or Accessory)\tHeart Fibrosarcoma (Neoplastic Process)", + "output": "Heart Fibrosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Research Activity described as the study of the protoplasmic boundary of all cells that controls permeability and may serve other functions through surface specializations; e.g., active ion transport absorption by formation of pinocytotic vesicles; receptor-mediated antigen recognition, etc.\nConcepts: Monocyte Chemoattractant Protein 2 (beta-Chemokines)\tMutations, Germ-Line (Mutation)\tMembrane Biology (Research Activity)\tEndocanthion (Body Location or Region)\tsodium-hydrogen exchanger 1 protein, human (Carrier Proteins)", + "output": "Membrane Biology (Research Activity)" + }, + { + "input": "Definition: something described as problem related to an obstruction or blockage within the device component (e.g. tube, opening, pipe) that results in a reduction of the flow rate.\nConcepts: Methoxsalen-containing product (Antineoplastic Agents)\tRetinal Examination (Diagnostic Procedure)\tNOROVIRUS GENOGROUP II.4 (Virus)\tBlockage within Medical Device (Finding)\tCD36 antigen (Receptors, Cell Surface)", + "output": "Blockage within Medical Device (Finding)" + }, + { + "input": "Definition: Medical Device described as a cement mixer for clinical use is a device consisting of a container intended for use in mixing bone cement (Sec. 888.3027).\nConcepts: Arteritides (Arteritis)\tMIXER, CEMENT, FOR CLINICAL USE (Medical Device)\tDisparities, Health Status (Health Status)\ttotal artificial organ (Implantation procedure)\tStructure of tegmentum of midbrain (Segment of midbrain)", + "output": "MIXER, CEMENT, FOR CLINICAL USE (Medical Device)" + }, + { + "input": "Definition: peptide hormone described as appetite-regulating hormone (117 aa, ~13 kDa) is encoded by the human GHRL gene. This protein is involved in satiety, thirst and anxiety and regulating growth hormone release.\nConcepts: regulation of response to tumour cell (Physiologic Function)\tFAC057-Losing Hope Against Illness (FACT/GOG-NTX Version 4 Questionnaire Question)\t/ml/(ug/m2/d) (Unit of concentration)\tMotilin Related Peptide (Amino Acid, Peptide, or Protein)\tADL0315B (ADCS-ADL MCI Questionnaire Question)", + "output": "Motilin Related Peptide (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Immunologic Factor described as an antineoplastic vaccine composed of autologous mature dendritic cells (mDCs) pulsed with mutated peptides, with potential immunostimulating and antineoplastic activities. Upon administration, the autologous mDC3 vaccine may elicit a cytotoxic T-cell (CTL) response against cancer cells.\nConcepts: Stiff ankle (Decreased range of ankle movement)\tAutologous Peptide-pulsed mDC3 Vaccine (Immunologic Factor)\tregulation of beta-nerve growth factor production (regulation of neurotrophin production)\tsocial issue (Thesaurus of Psychological Index Terms)\tYear of Last Study Visit Attended (Temporal Concept)", + "output": "Autologous Peptide-pulsed mDC3 Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: Region of myocardium described as myocardium of region of heart which is continuous with the tunica media of superior vena cava, inferior vena cava, and the trunk of pulmonary vein.\nConcepts: Fusobacteria (Bacterium)\tMyocardium of biatrial part of heart (Region of myocardium)\tSGRQ Past 3 Months Version - How Long Did Worst Respiratory Attack Last (Intellectual Product)\tProfessional Referral (Personnel Management & Professional Personnel Issues)\tAbnormality of the peripheral nervous system (Finding)", + "output": "Myocardium of biatrial part of heart (Region of myocardium)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Teen Report (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report) In the past 7 days, how much of a problem has this been for you: It is hard for me to go places with my equipment.\nConcepts: Lymphoid hyperplasia, NOS (Lymphoid hyperplasia)\tdextromethorphan acetic acid (Pharmacologic Substance)\tPurging (Symptomatology)\tPedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Hard to Go Places With Equipment (Intellectual Product)\tSystems, X-Ray, Tomographic (Radiographic/Fluoroscopic/Tomographic Units and Systems)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Hard to Go Places With Equipment (Intellectual Product)" + }, + { + "input": "Definition: something described as an anadromous species of SALMON ranging from the Arctic and Pacific Oceans to Monterey Bay, California and inhabiting ocean and coastal streams. It is familiarly known as the coho or silver salmon. It is relatively small but its light-colored flesh is of good flavor.\nConcepts: Oncorhyncus kisutch (Oncorhynchus)\tElectrocautery (Cauterization - action)\tEcotropic Virus Integration Site 1 Protein Homolog (MECOM Gene Product)\tvitamin B6 transmembrane transporter activity (Molecular Function)\tIslet Amyloid Polypeptide wt Allele (Gene or Genome)", + "output": "Oncorhyncus kisutch (Oncorhynchus)" + }, + { + "input": "Definition: Organic Chemical described as saw palmetto.\nConcepts: Sabal serrulata, homeopathic preparation (Organic Chemical)\tIon Channel and Phorbal Esters Signaling Pathway (Molecular Function)\tElectrochemiluminescence Immunoassay (Laboratory Procedure)\tAnticholinergic Syndromes (Autonomic nervous system disorders)\tHousehold Relative (Relative)", + "output": "Sabal serrulata, homeopathic preparation (Organic Chemical)" + }, + { + "input": "Definition: something described as michigan Neuropathy Screening Instrument - Physical Assessment: Right foot - vibration perception at great toe.\nConcepts: MNSI - Right Foot Vibration Great Toe (MNSI Questionnaire Question)\tren(o)- (Retroperitoneal Space)\tMAST CELL FUNCTION-ASSOCIATED ANTIGEN, RAT, HOMOLOG OF (Gene or Genome)\tlymph circulation (Physiologic Function)\tphotomultiplier (Medical Devices)", + "output": "MNSI - Right Foot Vibration Great Toe (MNSI Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as the disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components.\nConcepts: cystitis hemorrhagic (Hemorrhagic Disorders)\tchromosome localisation to nuclear envelope involved in homologous chromosome segregation (Chromosome Positioning)\tSCN1B Sodium Channel beta Subunit (Voltage-Gated Sodium Channel beta Subunits)\ttranscription ternary complex disassembly (Cell Function)\tConnection Problem (Device operational issue)", + "output": "transcription ternary complex disassembly (Cell Function)" + }, + { + "input": "Definition: Machine Activity described as the process by which an image is acquired or obtained.\nConcepts: AQ20 - Difficulty Getting Around the House Because of Chest Trouble (Intellectual Product)\tContrast Agent Finished Identifier (Intellectual Product)\tAutologous Specific HCC Antigens CD8+ T Cells (Antineoplastic Immune Cell)\tImage Acquisition (Imaging Technology)\tEOR01-Did You Need to Rest (EORTC QLQ-C30 Version 3 Questionnaire Question)", + "output": "Image Acquisition (Imaging Technology)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoid tumor that occurs during childhood.\nConcepts: millikatal (Unit of Catalytic Activity)\tChildhood Carcinoid Tumor (Neoplastic Process)\tN-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic Acid (Organic Chemical)\tcellular catabolism (Cell Function)\tDeinstitutionalization (Health Care)", + "output": "Childhood Carcinoid Tumor (Neoplastic Process)" + }, + { + "input": "Definition: something described as a strain of ENCEPHALOMYOCARDITIS VIRUS, a species of CARDIOVIRUS, usually causing an inapparent intestinal infection in mice. A small number of mice may show signs of flaccid paralysis.\nConcepts: glutamate homeostasis (amino acid homeostasis)\tB6 cell group (Cell)\tperiodically (Recurrent)\tCORYNEBACTERIUM COYLEAE (Bacterium)\tMurine encephalomyelitis virus (Encephalomyocarditis virus)", + "output": "Murine encephalomyelitis virus (Encephalomyocarditis virus)" + }, + { + "input": "Definition: something described as catalysis of the reaction: a hydroxyanthraquinone + UDP-D-glucose = a glucosyloxyanthraquinone + UDP.\nConcepts: alkyl hydroperoxide reductase complex location (Cell Component)\tRegulatory Documentation Category (Document type)\tCephalometric soft tissue plane (Body Location or Region)\tBPI Questionnaire Question (Clinical or Research Assessment Question)\thydroxyanthraquinone glucosyltransferase activity (Molecular Function)", + "output": "hydroxyanthraquinone glucosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the name of the compound that preserves tissues and cells for microscopic study.\nConcepts: SAR 442085 (Anti-CD38 Monoclonal Antibody)\tFixative Name (Conceptual Entity)\tMAS Probe Correction Method (Research Activity)\tcargo (Binding)\tpentachlorophenol (Herbicides)", + "output": "Fixative Name (Conceptual Entity)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the bacterial sialidase present in a sample.\nConcepts: Bacterial Sialidase Measurement (Laboratory Procedure)\tBone Leiomyoma (Fibroid Tumor)\tC-SSRS Lifetime/Recent Version (Clinical or Research Assessment Questionnaire)\tTsukamurella spongiae Olson et al. 2007 (Bacterium)\tMIP-1-alpha (CC Cytokine Gene)", + "output": "Bacterial Sialidase Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as an uncommon, benign, well circumscribed mesenchymal neoplasm that grows beneath the vaginal epithelium. It is characterized by the presence of cells containing bland ovoid, spindle, or stellate-shaped nuclei in a collagenous stroma.\nConcepts: TRIO Gene (Signaling Pathway Gene)\tproboscis extension in response to nutritional stimulus (Organism Function)\tHandling stress and other psychological demands (CHAPTER 2 GENERAL TASKS AND DEMANDS)\tSuperficial Cervicovaginal Myofibroblastoma (Vaginal Soft Tissue Neoplasm)\tditerpene phytoalexin precursor anabolism pathway (terpene biosynthetic process)", + "output": "Superficial Cervicovaginal Myofibroblastoma (Vaginal Soft Tissue Neoplasm)" + }, + { + "input": "Definition: Organism Function described as any process in which an organism modulates a change in state or activity of a host cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Augmented Cream Dosage Form (Cream)\tcyanophycin metabolic process (Peptide Metabolism)\tmodulation by symbiont of host response to thermal stimulus (modulation by symbiont of host response to abiotic stimulus)\tsubstance abuse prevention alcohol (Drug abuse prevention)\tIndividuations (Personality Development)", + "output": "modulation by symbiont of host response to thermal stimulus (modulation by symbiont of host response to abiotic stimulus)" + }, + { + "input": "Definition: Anatomical Abnormality described as extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix.\nConcepts: K CHANNELS CA ACTIVATED (Potassium Channel)\tHelix, crus, connected to antihelix (Abnormality of the crus of the helix)\tLEUKEMIA, CHRONIC MYELOMONOCYTIC (Myelodysplastic-Myeloproliferative Diseases)\tAustralian Shepherd dog (Mammal)\tFAC00622 (FACT-BL Version 4 Questionnaire Question)", + "output": "Helix, crus, connected to antihelix (Abnormality of the crus of the helix)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in tryptophan catabolism.\nConcepts: ELK1 wt Allele (Gene or Genome)\tMicrostomias (Musculoskeletal and connective tissue disorders of face, neck and jaw congenital)\tBeta-glucuronidase measurement, NOS (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tWoodcock-Johnson Tests of Cognitive Abilities (Intellectual Product)\tTDO2 Gene (Gene or Genome)", + "output": "TDO2 Gene (Gene or Genome)" + }, + { + "input": "Definition: Purine Nucleotides described as coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage; found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH).\nConcepts: Catheters, Angioplasty (Balloon dilatation catheter)\tproximal urethral cancer (Malignant neoplasm of urethra)\tExcessive cobalt intake (Excessive mineral intake)\tPeds-FACIT-F - I Feel Tired (Intellectual Product)\tnad (nicotinamide ribotide)", + "output": "nad (nicotinamide ribotide)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a fully human immunoglobulin G1 (IgG1) antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, anti-CTLA-4 monoclonal antibody REGN4659 targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system.\nConcepts: endometrial mucinous adenocarcinoma (Type I Endometrial Adenocarcinoma)\tREGN-4659 (Antineoplastic Antibody)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CRB1 (Medical Device)\tCETRELIMAB (Anti-PD1 Monoclonal Antibody)\tPrimary immunodeficiency syndrome with short stature (Dwarfism)", + "output": "REGN-4659 (Antineoplastic Antibody)" + }, + { + "input": "Definition: Complementary therapies described as a method of treating disease with small amounts of remedies that, in large amounts in healthy people, produce symptoms similar to those being treated. Homeopathy seeks to stimulate the body's defense mechanisms and processes so as to prevent or treat illness.\nConcepts: drug overdose (Substance-Related Disorders)\tCOWS108 (Intellectual Product)\thomoeopathy (Complementary therapies)\tNot Normal but Fairly Active (Finding)\tFAC062-My Family Has Accepted My Illness (Intellectual Product)", + "output": "homoeopathy (Complementary therapies)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an S100 protein characterized by four helix bundles that form N- and C-terminal EF HAND MOTIFS. It functions as a homodimer and interacts with both intracellular and extracellular signaling proteins. Aberrant S100A4 activity is associated with NEOPLASM METASTASIS; FIBROSIS; and RHEUMATOID ARTHRITIS.\nConcepts: 3-Hydroxytyramine (Adrenal medulla hormone)\tMetastasin Protein (S100 Proteins)\tDisorder of bile duct (Hepatobiliary Disorder)\tDalteparin-containing product (Heparin group antithrombotic drugs)\tdownregulation of chemotaxis to arachidonic acid (negative regulation of chemotaxis)", + "output": "Metastasin Protein (S100 Proteins)" + }, + { + "input": "Definition: something described as electric plugs designed to provide a higher level of protection from corrosion, impact, and electrical hazards than regular plugs when connected to an appropriate matching electric receptacle. These hospital-grade plugs are usually highly insulated and coated in heavy duty plastic to prevent damage to the plug; they have solid prongs that are usually nickel-plated, and include an internal cable retention device or strain relief to prevent any stress to the plug's internal connections. Hospital-grade electric plugs are intended for safe and reliable connection of an appliance to the power supply. They are used in hospital and healthcare facilities to provide protection against electric mishaps and prevent injuries.\nConcepts: Pharyngotympanic Tube (Eustachian Tube)\tTlinkit (Na-Dene Language)\tHospital Grade Electric Plugs (Electric Plugs)\tnegative regulation of elastin catabolism (negative regulation of glycoprotein metabolic process)\tVisceral peritoneum of uterus (UTERUS: GENERAL TERMS)", + "output": "Hospital Grade Electric Plugs (Electric Plugs)" + }, + { + "input": "Definition: something described as carbonated, iron-depleted mineral water from the French springs of Beauregard-Vendon (Rouzat) containing very high amounts of the mineral magnesium as well as sodium, calcium, potassium, bicarbonate, sulfate, chloride and nitrate, that can be used for supplemental purposes and can potentially be used to treat hypomagnesemia. Magnesium, an electrolyte, plays a key role as a cofactor in multiple enzymatic reactions and for muscle and nervous system functioning. Hypomagnesemia may manifest as asthenia, cramps, muscle weakness, fatigue, and mood disorders.\nConcepts: GAIA Provider Initiated Preterm Delivery Levels of Diagnostic Certainty (Intellectual Product)\tInflammation of the lymph nodes (infection due to other organisms)\tfertilization envelope (egg coat)\tadenosine diphosphate deaminase activity (adenosine-phosphate deaminase activity)\tMagnesium-rich Mineral Water (Food)", + "output": "Magnesium-rich Mineral Water (Food)" + }, + { + "input": "Definition: Abnormal CSF metabolite level described as abnormal concentration of biopterin in the cerebrospinal fluid (CSF). []\nConcepts: Infusion Related Reaction (Finding)\tAbnormal cerebrospinal fluid biopterin level (Abnormal cerebrospinal fluid metabolite concentration)\t1H-Purine-2,6-dione, 8-chloro-3,7-dihydro-1,3-dimethyl-, compd. with 2-(diphenylmethoxy)-N,N-dimethylethanamine (Organic Chemical)\tRNA, U19 small nucleolar (Genes, Regulator)\tHIST2BAB (Laboratory Procedure)", + "output": "Abnormal cerebrospinal fluid biopterin level (Abnormal cerebrospinal fluid metabolite concentration)" + }, + { + "input": "Definition: Pharmacologic Substance described as a humanized monoclonal antibody targeting the human cell surface antigen CD47, with potential immunostimulating and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody Hu5F9-G4 selectively binds to CD47 expressed on tumor cells and blocks the interaction of CD47 with its ligand signal regulatory protein alpha (SIRPa), a protein expressed on phagocytic cells. This prevents CD47/SIRPa-mediated signaling, allows the activation of macrophages, through the induction of pro-phagocytic signaling mediated by calreticulin, which is specifically expressed on the surface of tumor cells, and results in specific tumor cell phagocytosis. In addition, blocking CD47 signaling activates an anti-tumor T-lymphocyte immune response and T-mediated cell killing. CD47, a tumor associated antigen expressed on normal, healthy hematopoietic stem cells (HSC), is overexpressed on the surface of a variety of cancer cells. Expression of CD47, and interaction with SIRP-alpha, leads to inhibition of macrophages and protects cancer cells from phagocytosis thereby allowing cancer cells to proliferate.\nConcepts: Colonic Ulcer (Finding)\tSutures, Polybutester (Synthetic non-bioabsorbable suture)\tMastermind-Like 1 (Drosophila) wt Allele (MAML1 gene)\tMonomer deletion (Physical Phenomenon or Property)\tHu5F9-G4 (Amino Acid, Peptide, or Protein)", + "output": "Hu5F9-G4 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: regulation of cytokine production involved in immune response described as any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response.\nConcepts: ACKR4 (Chemokine Receptor Gene)\tsulfoacetaldehyde dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)\tregulation of cytokine secretion involved in immune response (regulation of cytokine secretion)\tCNS stimulant (Pharmacologic Substance)\tmelanosome transport (establishment of melanosome localization)", + "output": "regulation of cytokine secretion involved in immune response (regulation of cytokine secretion)" + }, + { + "input": "Definition: Abnormal cochlea morphology described as increased size of the cochlear duct, i.e., of a duct that communicates between the perilymphatic space and the subarachnoid space, and transmits a vein from the cochlea to join the internal jugular.\nConcepts: membranes (Tissue)\tAutosomal Recessive Retinitis Pigmentosa Gene Panel Reagents (IVD Panels, Human Genetics, Eye Disorder)\tSp1 Activation Cofactor Gene (Gene or Genome)\tEnlarged cochlear aqueduct (Finding)\tProminent frontal ridge (Abnormality of the metopic suture)", + "output": "Enlarged cochlear aqueduct (Finding)" + }, + { + "input": "Definition: Medicine described as a branch of medicine concerned with the relationship between emotion and body function.\nConcepts: PerformedImaging.enhancementDescription (Intellectual Product)\tLocal Skin Heating (Diagnostic Procedure)\tFBLN1-related developmental delay, central nervous system anomaly, syndactyly syndrome (Multiple malformation syndrome with limb defect as major feature)\tPsychosomatic Medicine (Psychiatry Specialty)\tEyelid Carcinoma pT1c TNM Finding v8 (Finding)", + "output": "Psychosomatic Medicine (Psychiatry Specialty)" + }, + { + "input": "Definition: something described as a rare, unilateral or bilateral benign retinal neoplasm. Since there is a risk of malignant transformation to retinoblastoma, patients should be closely observed.\nConcepts: eye neoplasm benign retinocytoma (Neoplastic Process)\tMicroanalytical Mechanical Balances (Medical Device)\tPODCI318 (Intellectual Product)\tTime of patient arrival to location for anaesthesia (Temporal Concept)\tIntra-arterial two or more substance injection each injection (Therapeutic or Preventive Procedure)", + "output": "eye neoplasm benign retinocytoma (Neoplastic Process)" + }, + { + "input": "Definition: Finding described as an anomaly in the processes involved in the maintenance of an internal equilibrium.\nConcepts: Measurement of oxalate (biochemical test)\tAbnormal homeostasis (Abnormality of metabolism/homeostasis)\tLAMP-3 (Gene or Genome)\tNutrition, Dietary Components (Research Activity)\tMalignancies (Classification)", + "output": "Abnormal homeostasis (Abnormality of metabolism/homeostasis)" + }, + { + "input": "Definition: HLA-A Gene Product, Human described as HLA class I histocompatibility antigen, A-0301 alpha chain (365 aa, ~41 kDa) is encoded by the HLA-A gene. This protein is involved in the presentation of foreign antigens to the immune system. This isoform is associated with increased risk for multiple sclerosis and is a secondary risk factor for myasthenia gravis.\nConcepts: MHC Class I Antigen HLA-A0301 Heavy Chain (Immunologic Factor)\tgastroenteritis bacterial (Bacterial infections NEC)\tCALCULATOR, PULMONARY FUNCTION DATA (Medical Device)\tepithelial cell migration involved in mesonephric distal tubule morphogenesis (epithelial cell migration involved in distal tubule morphogenesis)\tfamily life (Social Behavior)", + "output": "MHC Class I Antigen HLA-A0301 Heavy Chain (Immunologic Factor)" + }, + { + "input": "Definition: Finding described as nasal cavity and ethmoid sinus cancer with a finding of carcinoma in situ.\nConcepts: Myoglobinurias (Abnormal urinary product)\tcytidine transmembrane transporter activity (Molecular Function)\tComorbidity Index (Quantitative Concept)\tNasal Cavity and Ethmoid Sinus Cancer pTis TNM Finding v6 (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RYR2 (Medical Device)", + "output": "Nasal Cavity and Ethmoid Sinus Cancer pTis TNM Finding v6 (Finding)" + }, + { + "input": "Definition: Chemical procedure described as a measurement of the thiamine in a biological specimen.\nConcepts: Thiamine (Laboratory Procedure)\tQualifier Origin (Beginning)\tTSCC - Being Afraid of the Dark (Intellectual Product)\tGS2 Gene Mutation (Gene Mutant)\tlens epithelial cell proliferation (Epithelial Cell Proliferation)", + "output": "Thiamine (Laboratory Procedure)" + }, + { + "input": "Definition: Thiazolidinedione Antidiabetic Agent described as an agent belonging to the glitazone (thiazolidinedione) class of antidiabetic agents with antihyperglycemic activity. Ciglitazone also exerts anti-inflammatory activity through the modulation of nuclear factor-kappaB-mediated pathways. In addition, this agent inhibits angiogenesis by reducing vascular endothelial growth factor (VEGF) production and inhibits growth of melanoma cells by inhibiting the expression of (C-X-C motif) ligand 1 (CXCL1). This agent is the prototypical compound for the thiazolidinedione class, and has never been marketed.\nConcepts: Ciglitazone (Pharmacologic Substance)\t5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one (Organic Chemical)\tAscophyllum (Eukaryote)\tBPI126 (Intellectual Product)\tKFSS1-Cerebellar Functions (Intellectual Product)", + "output": "Ciglitazone (Pharmacologic Substance)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a fiber pathway from the amygdala to the striatum that is not readily distinguished in myelin-stained histological cross-sections ( Carpenter-1991 ).\nConcepts: Grass Mix Pollen Antigen IgA Antibody Measurement (Immunoglobulin measurement)\tamygdalostriate fibers (Body Part, Organ, or Organ Component)\t(Anankastic personality) or (anankastic personality disorder) (Personality Traits)\tDDS02TC (CDISC Questionnaire Terminology)\tDepression Score 5 (Intellectual Product)", + "output": "amygdalostriate fibers (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Mastectomy described as a surgical procedure in which there is full-thickness excision of the malignant breast tumor and surrounding breast parenchyma to allow resection with wide surgical margins, while the remaining fibroglandular breast tissue is transposed to preserve the breast shape and cosmetic appearance in the best possible way.\nConcepts: Amben ethyl ester (Organic Chemical)\trho GDP Dissociation Inhibitor 2 (rho-Specific Guanine Nucleotide Dissociation Inhibitors)\tEleven to Twenty Activity Hours (Clinical or Research Assessment Answer)\tOncoplastic Surgery (Therapeutic or Preventive Procedure)\tganglia (Neuroanatomy)", + "output": "Oncoplastic Surgery (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as human BRINP1 wild-type allele is located within 9q32-q33 and is approximately 203 kb in length. This allele, which encodes BMP/retinoic acid-inducible neural-specific protein 1, is involved in the modulation of cellular proliferation, the inhibition of the G1/S transition of the cell cycle, the mediation of non-apoptotic cell death and the regulation of the expression of components of the fibrinolysis pathway. Hypermethylation-based silencing or loss of homozygosity of the gene occurs in many cases of bladder cancer.\nConcepts: formic acid oxidation (Molecular Function)\tFoetal megacystis (Dilatation of the bladder)\tregulation of interleukin-8 biosynthesis (Cell Function)\tMelanoma of the Iris pT4b TNM Finding v7 (Melanoma of the Iris pT4 TNM Finding v7)\tFAM5A (BRINP1 gene)", + "output": "FAM5A (BRINP1 gene)" + }, + { + "input": "Definition: something described as an orally bioavailable, selective and reversible antagonist of C-X-C motif chemokine receptors 1 (CXCR1) and 2 (CXCR2), with potential anti-inflammatory and antineoplastic activities. Upon administration CXCR1/2 inhibitor SX-682 selectively and allosterically binds to CXCR 1 and 2 and inhibits their activation by tumor-secreted chemokines. This inhibits CXCR1/2-mediated signaling, reduces both recruitment and migration of immunosuppressive myeloid-derived suppressor cells (MDSCs) and neutrophils in the tumor microenvironment (TME), inhibits inflammatory processes and abrogates the immunosuppressive-induced nature of the TME. This allows effector cells, such as natural killer (NK) cells and cytotoxic T-lymphocytes (CTLs), to kill and eliminate cancer cells. This inhibits tumor cell migration, metastasis, angiogenesis and tumor cell proliferation. CXCR1 and 2, G protein-coupled receptor proteins located on myeloid cells and certain tumor cells, play key roles in the immunosuppressive nature of the TME, tumor metastasis, therapy-resistance and myeloid cell suppression. They play a key role in inflammation and their expression is elevated in several inflammatory-driven diseases.\nConcepts: Cxcr1/2 inhibitor SX-682 (CXCR4 Inhibitor)\tOptimization of medication (Medication Management)\tcicadae/chan tui (Oriental herbs and natural substances letter C)\tExperimental Psychology, Animal (Occupation or Discipline)\t10: 22650146-22660194 (Chromosome 10 Physical Location)", + "output": "Cxcr1/2 inhibitor SX-682 (CXCR4 Inhibitor)" + }, + { + "input": "Definition: Global Response described as regression of measurable disease with complete response in skin and nodes, blood and viscera categories not having complete response or noninvolvement and where no category has progressive disease. Partial response is also assigned when there is partial response in skin and no nodes, blood and viscera category has a progressive disease and if any category involved at baseline at least one has a complete or partial response.\nConcepts: PR (Global Response)\tRecorders, Tape, Physiologic (Recorders, Physiologic, Vital Signs)\tM\u00e9n\u00e9trier (Gastritis)\tUrinary System Finding (Finding by site)\tSubject ID (Intellectual Product)", + "output": "PR (Global Response)" + }, + { + "input": "Definition: Cell Component described as a protein complex that forms a subcomplex of the 90S preribosome and can interact directly with the 5' External Transcribed Spacer (ETS) of the full length pre-rRNA transcript. In S. cerevisiae, it sediments at 25-30 S and is composed of Pwp2p, Dip2p, Utp21p, Utp13p, Utp18p, and Utp6p.\nConcepts: UTP-B complex location (protein-containing complex)\tnucleotide-excision repair, DNA damage removal (Genetic Function)\tHyperalimentation, Parenteral (Therapeutic or Preventive Procedure)\t18 kDa Phosphoprotein (Amino Acid, Peptide, or Protein)\tGlasses (Lens)", + "output": "UTP-B complex location (protein-containing complex)" + }, + { + "input": "Definition: Genetic Function described as the occurrence of more than one organellar GENOME in the organelle population of a cell, tissue, or individual organism. It is due to the accumulation of different mutations that occur within the population of individual organelles of a cell.\nConcepts: Heteroplasmy (Genetic Function)\tDEFINE-ANLREAS (CDISC Define-XML Terminology)\tAbnormality of the extrinsic pathway (Blood Coagulation Disorders)\tParasitology one sample each test (Laboratory Procedure)\tTIMI 0 (Finding)", + "output": "Heteroplasmy (Genetic Function)" + }, + { + "input": "Definition: Spermatic Cord Hemorrhage, CTCAE described as transfusion indicated; invasive intervention indicated; hospitalization\nConcepts: entry of viral genome into host nucleus via docking of viral capsid to the nuclear pore complex and injection of viral genome (Genetic Function)\tGrade 3 Spermatic cord hemorrhage (Spermatic Cord Hemorrhage, CTCAE)\tTrinucleotide Repeat-Containing Gene 6B (TNRC6B gene)\tpositive regulation of L-methionine import across plasma membrane (positive regulation of amino acid transport)\tb mode ultrasound (Diagnostic Procedure)", + "output": "Grade 3 Spermatic cord hemorrhage (Spermatic Cord Hemorrhage, CTCAE)" + }, + { + "input": "Definition: Finding described as decrease in sexual interest adversely affecting relationship\nConcepts: nasal inhalers (Medical Device)\tgermline granule disassembly (Cell Function)\tGrade 2 Libido decreased (Libido Decreased, CTCAE)\tpositive regulation of cyanophore differentiation (Cell Function)\tintrinsic to plastid membrane (Cell Component)", + "output": "Grade 2 Libido decreased (Libido Decreased, CTCAE)" + }, + { + "input": "Definition: Pharmacologic Substance described as the fumarate salt form of the mineral iron. Administration of ferrous fumarate results in elevation of serum iron concentration, which is then assimilated into hemoglobin, required for the transport of oxygen, or trapped in the reticuloendothelial cells for storage. This agent is used as a dietary supplement, and to prevent or treat iron deficiency related syndromes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C61763\" active clinical trials using this agent.\nConcepts: Concentrated Fortified Collagen Protein Hydrolysate Liquid Supplement (Dietary Supplements)\tnegative regulation of muscle filament sliding (regulation of muscle filament sliding)\tFIHP (Familial hyperparathyroidism)\tDecreased platelet glycoprotein VI (Finding)\tFerrous Fumarate (Iron-containing product in oral dose form)", + "output": "Ferrous Fumarate (Iron-containing product in oral dose form)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of arginine biosynthetic process.\nConcepts: ferric transporting ATPase activity (Molecular Function)\tStage II Renal Cell Cancer (Renal Cell Cancer by AJCC v7 Stage)\tCDISC Questionnaire RAND Social Support Survey Test Code Terminology (Intellectual Product)\tAnkyrins (Amino Acid, Peptide, or Protein)\tregulation of arginine biosynthesis (regulation of arginine metabolic process)", + "output": "regulation of arginine biosynthesis (regulation of arginine metabolic process)" + }, + { + "input": "Definition: Nerve Agents described as the V-series nerve agent CVX.\nConcepts: Computer Hard Disc (Manufactured Object)\tMyxococcales Tchan et al. 1948 (Bacterium)\tBarlow's maneuver (Diagnostic Procedure)\tPsychiatric nursing (Specialties, Nursing)\tChinese VX (Nerve Agents)", + "output": "Chinese VX (Nerve Agents)" + }, + { + "input": "Definition: Equipment and Supplies described as artificial substitutes for body parts, and materials inserted into tissue for functional, cosmetic, or therapeutic purposes. Prostheses can be functional, as in the case of artificial arms and legs, or cosmetic, as in the case of an artificial eye. Implants, all surgically inserted or grafted into the body, tend to be used therapeutically. IMPLANTS, EXPERIMENTAL is available for those used experimentally.\nConcepts: negative regulation of IL-9 production (negative regulation of cytokine production)\tmsg therp ref.nc (Health Care Activity)\tMegaelectron Volt (Quantitative Concept)\tProsthetic Implant (Universal Medical Device Nomenclature System)\txstng 15min inofc (Existing client in-office without ICD diagnosis)", + "output": "Prosthetic Implant (Universal Medical Device Nomenclature System)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as ion Channel Proteins typically aggregate in membrane-associated complexes forming pores whose activities regulate the movement of ions through cellular membranes to affect cellular homeostatic conditions and/or signaling processes.\nConcepts: FAC05005 (Intellectual Product)\tVery dissatisfied (Finding)\tIon Channel Protein (Carrier Proteins)\tDNA replication, Okazaki fragment processing (Genetic Function)\tMeasurement of mercury (Heavy metal screen)", + "output": "Ion Channel Protein (Carrier Proteins)" + }, + { + "input": "Definition: beta Thalassemia described as dominant beta-thalassaemia is a form of beta-thalassaemia resulting in moderate to severe anaemia. Prevalence of this form is not known. Presents with moderate to severe anaemia, jaundice and splenomegaly. Rare mutations in the beta-globin HBB gene result in synthesis of extremely unstable beta-globin variants which precipitate in erythroid precursors causing ineffective erythropoiesis.\nConcepts: 1,4-alpha-D-glucan 4-alpha-D-(1,4-alpha-D-glucano)-transferase (hexosyltransferase activity)\tInclusion body beta-thalassaemia (Autosomal dominant hereditary disorder)\tcolonic ischemia (Colonic Diseases)\tChromosome 3q29 duplication syndrome (Partial trisomy of chromosome 3)\tCMV-immune globulin (Human Immunoglobulin G [EPC])", + "output": "Inclusion body beta-thalassaemia (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual is or was bothered by night sweats.\nConcepts: Night sweats (Clinical or Research Assessment Question)\tOEF1 (SAMD9 gene)\tMIR93 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tRun-On Assays (RNA Analysis)\tAbsence of the colon (Congenital Abnormality)", + "output": "Night sweats (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Psychiatric Disorders, CTCAE described as a disorder characterized by a false sensory perception in the absence of an external stimulus.\nConcepts: Aganglionic Megacolon Gene Panel Reagents (Medical Device)\tDepression, CTCAE (Psychiatric Disorders, CTCAE)\tJAK2 G935R (Cell or Molecular Dysfunction)\tHallucinations (Psychiatric Disorders, CTCAE)\tMedication Administration: Interpleural (Procedure on pleural cavity)", + "output": "Hallucinations (Psychiatric Disorders, CTCAE)" + }, + { + "input": "Definition: Optic Nerve described as the portion of the retina at which the axons of the ganglion cells exit the eyeball to form the optic nerve.\nConcepts: Hooks, Surgical, Vasectomy (Surgical Hooks)\tSPINT1 (Gene or Genome)\tSRP-dependent cotranslational protein-membrane targeting, translocation (intracellular protein transmembrane transport)\tPalatal angioectasia (Finding)\tOptic nerve head (EYES AND EYE APPENDAGES)", + "output": "Optic nerve head (EYES AND EYE APPENDAGES)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an alcohol test system is a device intented to measure alcohol (e.g., ethanol, methanol, isopropanol, etc.) in human body fluids (e.g., serum, whole blood, and urine). Measurements obtained by this device are used in the diagnosis and treatment of alcohol intoxication and poisoning.\nConcepts: DELAYED ANALYSIS, ALCOHOL (Indicator, Reagent, or Diagnostic Aid)\tDefined Contingent On Relationship Pause Quantity (Temporal Concept)\tApocrine Poroma (Neoplastic Process)\tpositive regulation of necrotic cell death (regulation of necrotic cell death)\tBLANG (Population Group)", + "output": "DELAYED ANALYSIS, ALCOHOL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Disease or Syndrome described as renal papillary necrosis in a patient with sickle cell disease or sickle cell trait.\nConcepts: receptor, muscarinic cholinergic Hm1, human (Amino Acid, Peptide, or Protein)\tRenal papillary necrosis due to sickle cell disease (Kidney Papillary Necrosis)\tIMD 760 (Pharmacologic Substance)\tBCL-2 Homology 2 Domain (Amino Acid Sequence)\tERG Rearrangement Analysis (Laboratory Procedure)", + "output": "Renal papillary necrosis due to sickle cell disease (Kidney Papillary Necrosis)" + }, + { + "input": "Definition: Coping stress tolerance finding described as difficulty in fulfilling care responsibilities, expectations and/or behaviors for family or significant others.\nConcepts: Surgical instrument clip (Clip)\tcaregiver role strain (Coping stress tolerance finding)\t87U6 (Gene or Genome)\tAJELLOMYCES CAPSULATUS (Ajellomyces)\tNon-Neoplastic Finding Type (CDISC SEND Terminology)", + "output": "caregiver role strain (Coping stress tolerance finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a radioconjugate containing a synthetic bombesin receptor antagonist targeting the gastrin-releasing peptide receptor (GRPR), that is linked by the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to the radionuclide gallium (Ga) 68, with potential use in diagnostic imaging using positron emission tomography/computed tomography (PET/CT). Upon administration of gallium Ga 68 GRPR antagonist BAY86-7548, the peptide moiety targets and binds to GRPR. Upon PET/CT, GRPR-expressing tumor cells can then be visualized. GRPR, also called bombesin receptor 2 (BB2), is a G protein-coupled seven-transmembrane receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121773\" active clinical trials using this agent.\nConcepts: GAC codon-amino acid adaptor activity (Genetic Function)\tElectrodes, Neurologic, Evoked Potential, Visual, Electroretinography (Electrodes, Neurologic, Evoked Potential, Visual)\tCart Object (Conceptual Entity)\tGallium Ga 68-labeled GRPR Antagonist BAY86-7548 (Radioimmunoconjugates)\tcardiac sudden death (Acute heart disease)", + "output": "Gallium Ga 68-labeled GRPR Antagonist BAY86-7548 (Radioimmunoconjugates)" + }, + { + "input": "Definition: Conceptual Entity described as members of the set of the smallest units of speech that serve to distinguish one utterance from another, such as the p of pat and the f of fat. Used both for the concept of phonemes as well as the discipline of phonemics. Compare PHONOLOGY.\nConcepts: Phonetic (Intellectual Product)\tRan GTPase Activating Protein 1 wt Allele (Gene or Genome)\telectromyography emg (Diagnostic Procedure)\tHAMD4 (Intellectual Product)\tLymphomas, Plasmablastic (B-cell lymphoma morphology)", + "output": "Phonetic (Intellectual Product)" + }, + { + "input": "Definition: Intraabdominal Route of Drug Administration described as a route that begins within the urethra.\nConcepts: Endoscopes, Subcutaneous Tunnel, Vessel Harvesting (Endoscopes)\tGTP biosynthesis (Molecular Function)\tURETH (Drug Administration Routes)\tinduction by symbiont of host receptor-mediated signal transduction (Organism Function)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Selective (Medical Device)", + "output": "URETH (Drug Administration Routes)" + }, + { + "input": "Definition: Intellectual Product described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the reproductive system findings domain.\nConcepts: DRRI-2 - K: Touched Sexual Way Against Will (DRRI-2 Questionnaire Question)\tZ-phenylacetaldoxime breakdown (Molecular Function)\tNasopharyngo- (Respiratory System)\tSupplemental Qualifiers for Reproductive System Findings (Supplemental Qualifiers Tabulation Dataset)\tParakeratosis, NOS (Dysplasia)", + "output": "Supplemental Qualifiers for Reproductive System Findings (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: Squamous cell carcinoma of the head and neck described as a head and neck squamous cell carcinoma that does not respond to treatment.\nConcepts: Inclusion, Cellular (Cellular Structures)\tKAINATE RECEPT (Receptors, Ionotropic Glutamate)\tinformation processing (Mental Process)\tRefractory Head and Neck Squamous Cell Cancer (Refractory Head and Neck Carcinoma)\tVeterans Health Services (Health Services)", + "output": "Refractory Head and Neck Squamous Cell Cancer (Refractory Head and Neck Carcinoma)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transmembrane transport.\nConcepts: In the past 7 days, how much did problems with memory interfere with your usual or daily activities (Clinical or Research Assessment Question)\tNADPH:2-(2-ketopropylthio)ethanesulfonate oxidoreductase/carboxylase activity (oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor)\tPCANAP8 (Gene or Genome)\tPneumatic Intermittent Impulse Device (Cardiovascular equipment)\tEconomic Burden (Burden)", + "output": "PCANAP8 (Gene or Genome)" + }, + { + "input": "Definition: Ocular infections, inflammations and associated manifestations described as tuberculous infection of the eye, primarily the iris, ciliary body, and choroid.\nConcepts: Pterygospinal igament (Skeletal ligament)\tFTDOSD (Quantitative Concept)\tOcular tuberculosis (Tuberculosis)\tpirinitramide (Isonipecotic Acids)\tScrub Suits, Reusable (Scrub suit)", + "output": "Ocular tuberculosis (Tuberculosis)" + }, + { + "input": "Definition: Transplant-Related Carcinoma described as a hepatocellular carcinoma that arises in a patient with a history of organ transplantation.\nConcepts: Abnormal circulating homocysteine concentration (Finding)\tTransplant-Related Hepatocellular Carcinoma (Neoplastic Process)\thepatitis fulminant (Hepatocellular damage and hepatitis NEC)\tup regulation of actin-dependent ATPase activity (regulation of actin-dependent ATPase activity)\t2D mode ultrasound (Ultrasound - action)", + "output": "Transplant-Related Hepatocellular Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as the time period comprising Saturday and Sunday, and sometimes considered to include Friday night.\nConcepts: interleukin-34-mediated signaling pathway (cytokine-mediated signaling pathway)\tweekends (Temporal Concept)\tMuscle weakness left-sided (Finding)\tBixas (Bixaceae)\tDIPG Brain Tumor (Malignant glioma of brainstem)", + "output": "weekends (Temporal Concept)" + }, + { + "input": "Definition: something described as a genus of plump but extremely strong mustelids with a relatively short tail, in the subfamily Mustelinae.\nConcepts: Wolverines (Martinae)\tlithium ion export (lithium ion transport activity)\tAnterior Commissure, Brain (Body Space or Junction)\tSpermatic Cord Stenosis (Disease or Syndrome)\tCHAMBER, ENVIRONMENTAL FOR THE STORAGE OF PLATELET CONCENTRATE (Medical Device)", + "output": "Wolverines (Martinae)" + }, + { + "input": "Definition: Lung diseases described as a rare congenital cardiopulmonary defect characterized by abnormal right-sided pulmonary venous drainage and right lung malformations.\nConcepts: immune system development (Biologic Function)\tSCIMITAR SYNDROME (Rare Non-Neoplastic Disorder)\tGround Strap Device (Device Component or Accessory)\tbooster immunizations (Therapeutic or Preventive Procedure)\tIn Situ Nick-End Labelling (Genetic Techniques)", + "output": "SCIMITAR SYNDROME (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Organic Chemical described as coca, the divine plant of the Incas.\nConcepts: evening-primrose family (Myrtales)\tcal IT (Calorie Unit)\tMagnitude Estimation (Psychophysical Measurement)\tErythroxylon coca / coca / the divine plant of the Incas (Homeopathic remedies letter E)\tStage II Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 (Neoplastic Process)", + "output": "Erythroxylon coca / coca / the divine plant of the Incas (Homeopathic remedies letter E)" + }, + { + "input": "Definition: something described as absence of the middle phalanx of the little (5th) finger.\nConcepts: Lansoprazoles (Medicinal product categorized by structure)\tAbsent middle phalanx of 5th finger (Aplasia of the middle phalanx of the hand)\tIPAQ Long Last 7 Days Self-Administered Format Version - Vigorous Garden Hours per Day (Intellectual Product)\tMathematics (Thesaurus of Psychological Index Terms)\tDANICOPAN (Pharmacologic Substance)", + "output": "Absent middle phalanx of 5th finger (Aplasia of the middle phalanx of the hand)" + }, + { + "input": "Definition: Medical Device described as serology reagents intended to detect immunoglobulin M (IgM) antibodies to Lassa fever virus, an enveloped RNA virus of the old world group of Arenaviruses (i.e., LCM/Lassa complex) of the family Arenaviridae. This virus may cause acute hemorrhagic fever in humans (known as Lassa fever); it is usually associated with multimammate rats (Mastomys natalensis) by which the virus is transmitted to humans.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Arenavirus, Lassa Virus, IgM Antibody (IVD Test Reagent/Kits, Serology, Virus, Arenavirus)\tOblique Fetal Presentation (Fetal presentation finding)\tvery-low-density lipoprotein complex (triglyceride-rich plasma lipoprotein particle)\tBacterial infection of skin (Bacterial Infections)\tDRRI1H07 (Intellectual Product)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Arenavirus, Lassa Virus, IgM Antibody (IVD Test Reagent/Kits, Serology, Virus, Arenavirus)" + }, + { + "input": "Definition: Homeopathic remedies letter O described as homeopathic remedy\nConcepts: ozone (Homeopathic remedies letter O)\th.ug/mL/(mg/kg) (Measurement Unit Description)\ttrehalose transport in response to desiccation (trehalose transport in response to water deprivation)\tConferences, Consensus Development as Topic (Intellectual Product)\tmaintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter (maintenance of transcriptional fidelity during DNA-templated transcription elongation)", + "output": "ozone (Homeopathic remedies letter O)" + }, + { + "input": "Definition: Area Under Curve described as the observed area under the curve (AUC) extrapolated to infinity divided by the dose.\nConcepts: Depilations (Surgical Manipulation)\tenterochelin synthetase complex location (Cell Component)\tDomeboro Solution (Astringents)\tMatricaria recutita / Roman camomile (Pharmacologic Substance)\tAUCIFOD (Area Under Curve)", + "output": "AUCIFOD (Area Under Curve)" + }, + { + "input": "Definition: Abdominal and gastrointestinal infections described as an acute or chronic infectious process affecting the stomach.\nConcepts: QLES1-Felt Full of Pep and Vitality (Intellectual Product)\tRecombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine (Cell)\tgastric infection (Infection of digestive system)\tFeeding environment distraction management (Nutrition environment management)\tballs (Scrotal and testis structures)", + "output": "gastric infection (Infection of digestive system)" + }, + { + "input": "Definition: something described as work Productivity and Activity Impairment Questionnaire - Specific Health Problem V2.0 test code.\nConcepts: mononeuropathies (Disease or Syndrome)\tup regulation of axial mesodermal cell fate determination (positive regulation of mesodermal cell fate determination)\tCDISC Questionnaire WPAI:SHP v2.0 Test Code Terminology (Intellectual Product)\tYttrium Y-90-DOTA-Girentuximab (Radioimmunoconjugates)\tRADIOIMMUNOASSAY, BARBITURATE (Indicator, Reagent, or Diagnostic Aid)", + "output": "CDISC Questionnaire WPAI:SHP v2.0 Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as a vaccine formulation consisting of recombinant vaccinia virus encoding prostate specific antigen (PSA) and recombinant vaccinia virus encoding three co-stimulatory molecule transgenes B7.1, ICAM-1, and LFA-3 (TRICOM). Vaccination with PSA in combination with TRICOM may enhance antigen presentation, resulting in the augmentation of a cytotoxic T cell (CTL) immune response against tumor cells expressing PSA.\nConcepts: IFI6 Measurement (Laboratory Procedure)\tGrade 4 Hypernatremia (Finding)\tdown regulation of glial cell differentiation (Cell Function)\tGenital ambiguity (Reproductive System Finding)\tvPSA-TRI (Immunologic Factor)", + "output": "vPSA-TRI (Immunologic Factor)" + }, + { + "input": "Definition: regulation of intrinsic apoptotic signaling pathway described as any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway by p53 class mediator.\nConcepts: APPLIER, STAPLE, SURGICAL, (Suturing unit)\tregulation of protein localization to cell division site (regulation of cellular protein localization)\tregulation of intrinsic apoptotic signaling pathway by p53 class mediator (Molecular Function)\toxidative single-stranded RNA demethylation (Genetic Function)\tZona Pellucida Glycoprotein-2 (Biologically Active Substance)", + "output": "regulation of intrinsic apoptotic signaling pathway by p53 class mediator (Molecular Function)" + }, + { + "input": "Definition: something described as human TSPAN3 wild-type allele is located in the vicinity of 15q24.3 and is approximately 43 kb in length. This allele, which encodes tetraspanin-3 protein, is involved in signal transduction.\nConcepts: Pontine ischemic lacunes (Pathologic Function)\tTandem Mass Spectrometry (Mass Spectrometry)\tpre-small nucleolar ribonucleoprotein complex (Cell Component)\tEmergency Power Failure (Finding)\tTM4SF8 (Gene or Genome)", + "output": "TM4SF8 (Gene or Genome)" + }, + { + "input": "Definition: ULBP1 gene described as human ULBP1 wild-type allele is located in the vicinity of 6q25 and is approximately 10 kb in length. This allele, which encodes NKG2D ligand 1 protein, plays a role in the production of both cytokines and chemokines by natural killer cells.\nConcepts: otic vesicle morphogenesis (embryonic organ morphogenesis)\tNKG2DL1 (Gene or Genome)\tSusu language (Language)\tcarbohydrate breakdown (Carbohydrate Metabolism)\tInterna, Theca (Ovary)", + "output": "NKG2DL1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a molecular genetic abnormality indicating the presence of a mutation in intron 13 of the MET gene.\nConcepts: Climax (Coitus)\tWhite Oak Pollen IgE AB RAST Score (Immunoglobulin E measurement)\tDAUNORUBICIN/CYTARABINE (Pharmacologic Substance)\tHGFR Intron 13 Mutation (MET Gene Mutation)\tEnah/Vasp-Like wt Allele (Gene or Genome)", + "output": "HGFR Intron 13 Mutation (MET Gene Mutation)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) In the past 4 weeks, did the subject keep appointments or meetings with other people, such as relatives, a doctor, the hairdresser, etc.?\nConcepts: NGF receptor activity (Molecular Function)\tDDS0214 (Intellectual Product)\tSeneca Valley virus-001 (Virus)\tADCS-ADL - Keep Appointments or Meetings with Others (ADCS-ADL Questionnaire Question)\tcontraction muscles (muscle system process)", + "output": "ADCS-ADL - Keep Appointments or Meetings with Others (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: rnax medication actions described as managing, monitoring and/or caring for a patient while he or she is undergoing chemotherapy.\nConcepts: GAS CHROMATOGRAPHY, MORPHINE (Medical Device)\tStage IIIB Uterine Corpus Cancer AJCC v8 (Neoplastic Process)\tChemotherapy care (drug management)\tSARACATINIB DIFUMARATE (Protein-tyrosine kinase inhibitor)\tAdjuvant Post-operative Targeted Molecular Therapy Was Administered (Finding)", + "output": "Chemotherapy care (drug management)" + }, + { + "input": "Definition: Cytochrome P450 Family Gene described as this gene plays a role in the metabolism of drugs, xenobiotics, fatty acids and steroids. It is also involved in the synthesis of estriol during pregnancy.\nConcepts: side effect (Pathologic Function)\tCYP3A7 gene (Cytochrome P450 Family Gene)\tANTISERA, FLUORESCENT, CHLAMYDIA SPP. (Medical Device)\tBody odor (Finding)\tAsp-tRNAAsn amidotransferase activity (catalytic activity, acting on a tRNA)", + "output": "CYP3A7 gene (Cytochrome P450 Family Gene)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Leukemia Version 4 (FACT-LEU Version 4) Physical Well-Being: I am bothered by side effects of treatment.\nConcepts: Prostheses, Upper Limb, Below Elbow (Medical Device)\tFACT-LEU Version 4 - Bothered by Treatment Side Effect (FACT-LEU Version 4 Questionnaire Question)\tPulmonary Surfactant Associated Protein A (Pulmonary Surfactant-Associated Proteins)\tMGC17251 (Gene or Genome)\tDistal Bile Duct Cancer TNM Finding v8 (Hepatobiliary System Cancer TNM Finding v8)", + "output": "FACT-LEU Version 4 - Bothered by Treatment Side Effect (FACT-LEU Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Neoplastic Process described as childhood acute myeloid leukemia (AML) characterized by deletion of chromosome 7. This subgroup occurs in 4% of children with AML.\nConcepts: Endocardial Fibroelastosis (Structural disorder of heart)\tLYMPH NODE, SUBLINGUAL (Anatomical Structure)\tRight Ventricular Outflow Tract Tachycardia by EKG Finding (Disease or Syndrome)\tChildhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7 (Neoplastic Process)\tGrade 4 Immune system disorders - Other, specify (Finding)", + "output": "Childhood Acute Myeloid Leukemia with Abnormalities of Chromosome 7 (Neoplastic Process)" + }, + { + "input": "Definition: Finding related to weaning described as permanent deprivation of breast milk and commencement of nourishment with other food.\nConcepts: uOsM (Unit of Osmotic Pressure)\tHallucinating (Functions and Abnormal Functions of the Psyche)\tPosterior wedging (Wedging of vertebra)\tWeaning (child-rearing practice)\tpositive regulation of mitotic cohesin unloading (positive regulation of mitotic cell cycle)", + "output": "Weaning (child-rearing practice)" + }, + { + "input": "Definition: Blepharitis described as a type of blepharitis that affects the meibomian glands and meobomian gland orifices. This abnormality can be associated with a spectrum of appearances ranging from meibomian seborrhoea (foaming meibomian gland secretions) and meibomianitis (inflamed meibomian glands), to chalazia.\nConcepts: Stage I Esophageal Adenocarcinoma (Esophageal Adenocarcinoma by AJCC v8 Pathologic Stage)\tChest>Clavicle (Clavicular region)\tElevated intracellular cystine (Abnormal cellular physiology)\tRadiologic Nursing (Biomedical Occupation or Discipline)\tMeibomian gland disease (Lid, lash and lacrimal infections, irritations and inflammations)", + "output": "Meibomian gland disease (Lid, lash and lacrimal infections, irritations and inflammations)" + }, + { + "input": "Definition: Medical Subject Headings Norwegian described as formal programs that offer general, technical, or individualized studies for students of all ages.\nConcepts: Heat Exchange Catheters, Intravascular (Vascular Catheters)\tcone biopsy (cervical surgery)\tAvena sativa L. (Poaceae)\tDevice, Ear Protective (Protective Clothing)\teducation level (Croatian translation of the Medical Subject Headings)", + "output": "education level (Croatian translation of the Medical Subject Headings)" + }, + { + "input": "Definition: immunoglobulin mediated immune response described as a hypersensitivity reaction mediated by antibodies formed against cell surface antigens.\nConcepts: Setup Errors, Radiotherapy (Medical Errors)\tBRAIN, CEREBRUM (Body Part, Organ, or Organ Component)\tTrefoil Factor 2 (trefoil factor)\thomogentisate prenyltransferase activity (prenyltransferase activity)\tGell and Coombs reaction type II (Pathologic Function)", + "output": "Gell and Coombs reaction type II (Pathologic Function)" + }, + { + "input": "Definition: something described as no longer meeting criteria for at least clinical improvement after achieving complete response partial response or clinical improvement or loss of anemia response persisting for at least 1 month or loss of spleen response persisting for at least 1 month (adapted from Revised Response Criteria for Myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus report. BLOOD 22 AUGUST 2013 x VOLUME 122 NUMBER 8)\nConcepts: VIBRATORY URTICARIA (Dermatographic urticaria)\tglucuronate transmembrane transporter activity (Molecular Function)\tFlexor pollicis longus muscle tendon sheath (Tendon and/or tendon sheath structure)\tTCM (Alternative Medical System)\tIWG-MRT Myelofibrosis Relapse (IWG-MRT Criteria for Treatment Response in Myelofibrosis)", + "output": "IWG-MRT Myelofibrosis Relapse (IWG-MRT Criteria for Treatment Response in Myelofibrosis)" + }, + { + "input": "Definition: something described as an observation of an individual's pharyngoesophageal segment opening during swallowing.\nConcepts: regulation of bundle of His cardiac muscle cell action potential (Cell Function)\tCSS01-Suicidal Ideation-No Intent (C-SSRS Baseline Questionnaire Question)\tImpairment of Pharyngoesophageal Segment Opening (Finding)\tStage I Prostate Adenocarcinoma (Stage I Prostate Cancer AJCC v7)\tnegative regulation of cell cycle process (Cell Cycle Control)", + "output": "Impairment of Pharyngoesophageal Segment Opening (Finding)" + }, + { + "input": "Definition: Intellectual Product described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes (PARENT-DDS) During the past month, I have been: Feeling that no one notices that diabetes is hard on me, not just on my teen.\nConcepts: Epiphora NOS (Eye)\t9-fluorenone-3,4-dioxygenase activity (Molecular Function)\tDDS02-No One Notices Diabetes Hard on Me (Intellectual Product)\tchlorosome (Cell Component)\tinterleukin-15 formation (cytokine biosynthesis)", + "output": "DDS02-No One Notices Diabetes Hard on Me (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Delayed word recall task for word 4.\nConcepts: chondrocyte hypertrophy (Cell Function)\tADCDRL04 (ADAS-Cog CDISC Version Questionnaire Question)\t3-phosphoshikimate 1-carboxyvinyltransferase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)\tdADP phosphorylation (dADP metabolic process)\tObserved Cardiac Device Type (Type of device)", + "output": "ADCDRL04 (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: Cedecea described as a species of facultatively anaerobic, Gram-negative, bacilli assigned to the phylum Proteobacteria. This species is motile, non-spore forming, catalase positive, oxidase negative, lipase positive, indole negative, ornithine decarboxylase negative, does not ferment sucrose, reduces nitrate, does not produce hydrogen sulfide, and hydrolyzes esculin. C. lapagei is pathogenic especially in immunocompromised patients.\nConcepts: CEDECEA LAPAGEI (Cedecea)\tSodium 2-mercaptoethanesulfonate (Uroprotective Agent)\tgenotypes (Genome)\tLoeys-Dietz Syndrome Type 1 (Disease or Syndrome)\tAdenoviral- RheoSwitch Therapeutic System-Human Interleukin 12 (Gene Therapy Agent)", + "output": "CEDECEA LAPAGEI (Cedecea)" + }, + { + "input": "Definition: Brain ventricle part described as the connection between the lateral ventricles with the third ventricle, which allows for the flow of CSF between the structures.\nConcepts: BD1 (Protein or Enzyme Type Measurement)\tOvarian Small Cell Carcinoma (Neoplastic Process)\tSubject Unique Identifier (Intellectual Product)\tInterventricular foramen (Body Space or Junction)\tdown regulation of hormone secretion (Cell Function)", + "output": "Interventricular foramen (Body Space or Junction)" + }, + { + "input": "Definition: something described as a phylum of unsegmented helminths with fundamental bilateral symmetry and secondary triradiate symmetry of the oral and esophageal structures. Many species are parasites.\nConcepts: Abdominal lymph node group (Lymph node group of trunk)\tHooks, Surgical, Eye, Lens (Medical Device)\tRoundworm (Animals)\tIntestinal Gel Dosage Form (Dosage Form By Route Of Administration)\tWaveguides (Medical Device)", + "output": "Roundworm (Animals)" + }, + { + "input": "Definition: Immunologic Factor described as a cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.\nConcepts: Retinoblastoma cT2 TNM Finding v8 (Retinoblastoma Clinical Primary Tumor TNM Finding v8)\tFAC061-I Feel Ill (Intellectual Product)\tB-Cell Stimulatory Factor-2 (cytokine)\tScanty (WHO Mycobacterium Quantitation Scheme)\tT-Cell Activation Protein 2 (Amino Acid, Peptide, or Protein)", + "output": "B-Cell Stimulatory Factor-2 (cytokine)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual is or was rested.\nConcepts: Hereditary Hyperparathyroidism-Jaw Tumor Syndrome (Neoplastic Syndromes, Hereditary)\t4: 145419449-145388062 (Chromosome 4 Physical Location)\tImmunodiffusion Equipment (Medical Device)\tI am rested (Clinical or Research Assessment Question)\tMitotic Indices (Property or Attribute)", + "output": "I am rested (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as solution that is usually 10 percent glucose but may be higher. An isotonic solution of glucose is 5 percent.\nConcepts: hypertonic glucose solution (Hypertonic Solutions)\tendosome to lysosome transport of LDL (Cell Function)\tCLEFT-LIMB-HEART MALFORMATION SYNDROME (Congenital heart disease)\tAnisocytosis (Abnormality of red blood cells)\tNursing, Oncology (Specialties, Nursing)", + "output": "hypertonic glucose solution (Hypertonic Solutions)" + }, + { + "input": "Definition: Mammal described as an attentive, lively and devoted dog who is easy to train. The coat is long and the colors are varied. The average height range is 12-15 inches and the average weight range is 24-26 pounds.\nConcepts: peptide pheromone export involved in positive regulation of conjugation with cellular fusion (positive regulation of conjugation with cellular fusion)\tGerman Spitz (Non-Sporting Breed)\tPosterolateral Myocardial Infarction by EKG Finding (Finding)\tparalysis third cranial nerve (Paralytic strabismus)\tMEDIA, POTENTIATING FOR IN VITRO DIAGNOSTIC USE (Medical Device)", + "output": "German Spitz (Non-Sporting Breed)" + }, + { + "input": "Definition: something described as disturbance in the atrial activation that is caused by transient failure of impulse conduction from the SINOATRIAL NODE to the HEART ATRIA. It is characterized by a delayed in heartbeat and pauses between P waves in an ELECTROCARDIOGRAM.\nConcepts: Hemophilus bovis (Bacterium)\tElective termination of pregnancy (Therapeutic or Preventive Procedure)\tsa block (HEART RATE AND RHYTHM DISORDERS)\tmicrotubule-associated protein 2C, human (Amino Acid, Peptide, or Protein)\tcardiac enlargement (Cardiac Disorders, General, Functional and NEC)", + "output": "sa block (HEART RATE AND RHYTHM DISORDERS)" + }, + { + "input": "Definition: something described as beclin-2 (431 aa, ~48 kDa) is encoded by the human BECN2 gene. This protein is involved in both autophagy and the catabolism of G protein-coupled receptors.\nConcepts: middle ear morphogenesis (Organ or Tissue Function)\tThoracic Endoscopes (Body cavity endoscope)\tCervical Cancer pT2 TNM Finding v7 (Cervical Cancer Pathologic Primary Tumor TNM Finding v7)\tCAMERA, CINE, SURGICAL, WITHOUT AUDIO (Medical Device)\tBECN2 protein, human (Biologically Active Substance)", + "output": "BECN2 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Code described as a coded value specifying how often a dose is administered.\nConcepts: PLG wt Allele (Gene or Genome)\tBASIC SCIENCE (Research Activities)\tBTB Domain Containing 18 wt Allele (BTBD18 gene)\tdoseFrequencyCode (Code)\tD-glutamate:oxygen oxidoreductase (Molecular Function)", + "output": "doseFrequencyCode (Code)" + }, + { + "input": "Definition: something described as a genetic marker phenotype found in some cancers, this condition is marked by the presence of hundreds to thousands of mutations in microsatellite regions of chromosomes. These mutations are associated with decreased fidelity of DNA replication.\nConcepts: respiration (energy derivation by oxidation of organic compounds)\tMicrosatellite Mutator Phenotype (Organism Attribute)\tIDH1 NP 005887.2:p.R119Q (IDH1 Protein Variant)\tacquisita bullosa epidermolysis (Degenerative disorder)\tHGF receptor signaling pathway (transmembrane receptor protein tyrosine kinase signaling pathway)", + "output": "Microsatellite Mutator Phenotype (Organism Attribute)" + }, + { + "input": "Definition: Functional Concept described as obstruction or a closure of hollow organ, passageway or vessel; also the transient approximation of the edges of a natural opening; imperforation.\nConcepts: Microsomal Triglyceride Transfer Protein Large Subunit (Biologically Active Substance)\tAmpulla Hair Cells (Cell)\tApoptotic Protease Activating Factor 3 (Amino Acid, Peptide, or Protein)\tLumiliximab (Immunologic Factor)\tOcclusive (General site descriptor)", + "output": "Occlusive (General site descriptor)" + }, + { + "input": "Definition: Finding described as a finding of minimal chewing or mashing with majority of bolus unchewed prior to swallowing.\nConcepts: Minimal Chewing or Mashing with Majority of Bolus Unchewed (Impairment of Bolus Preparation or Mastication)\tHYPOADRENALISM (ENDOCRINE FEATURES)\tbreast carcinoma male (Breast Carcinoma)\tplacental disorders of chorion villitis of unknown etiology (Female Reproductive System Finding)\tSnares, Respiratory Tract, Endoscopic (Snare instrument)", + "output": "Minimal Chewing or Mashing with Majority of Bolus Unchewed (Impairment of Bolus Preparation or Mastication)" + }, + { + "input": "Definition: Spleen implantation described as transfer of spleen or spleen fragments within an individual or between individuals of the same or different species.\nConcepts: Feeling Intensity Score 1 (Intellectual Product)\tspleen transplantation (Other operations on spleen and bone marrow)\tFoul-in-the-foot (Skin Diseases, Bacterial)\th*pmol/L/kg (Measurement Unit Description)\t(Z,E)-alpha- farnesene synthase activity (carbon-oxygen lyase activity, acting on phosphates)", + "output": "spleen transplantation (Other operations on spleen and bone marrow)" + }, + { + "input": "Definition: Ophthalmologic Surgical Procedures described as a surgical technique for the transscleral resection of large, anteriorly located uveal melanomas with ciliary body and/or iris involvement. This approach is most common when conservative therapy is either unlikely to help, or likely to cause complications.\nConcepts: Exoresection (Therapeutic or Preventive Procedure)\tadrenaline regulation of the strength of heart muscle contraction (Molecular Function)\tMedian Atrial Rate by Electrocardiogram (Quantitative Concept)\tFishman Syndrome (Benign neoplasm of skin)\tLIMK1 Gene (Serine/Threonine Protein Kinase Gene)", + "output": "Exoresection (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a coded value specifying the reason why the entity is nullified.\nConcepts: regulation of interleukin-4-mediated signalling pathway (Molecular Function)\tnullificationReasonCode (Code)\tX-linked congenital dyserythropoietic anaemia with thrombocytopenia (Genetic Diseases, X-Linked)\tDrug Accountability Group Identifier (Group ID)\tMobile Health Units (DedicatedNonClinicalLocationRoleType)", + "output": "nullificationReasonCode (Code)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a variation in the amino acid sequence for the GTPase HRas protein.\nConcepts: H-Ras Protein Variant (Gene Product Sequence Variation)\tProstate Cancer Clinical TNM Finding v6 (Prostate Cancer TNM Finding v6)\tcrossing over (Functions and Abnormal Functions Associated with the Reproductive State)\tIncomitant strabismus (Strabismus)\tEbola virus disease not suspected (Finding)", + "output": "H-Ras Protein Variant (Gene Product Sequence Variation)" + }, + { + "input": "Definition: Post-transplant lymphoproliferative disorder described as a clonal B-cell lymphoproliferative disorder arising as a result of post-transplant immunosuppression therapy. It is characterized by destructive infiltration of lymph nodes and extranodal sites by a polymorphic B-cell infiltrate composed of small and medium sized lymphocytes, immunoblasts, and plasma cells. In some cases, reduction of the immunosuppression therapy may lead to regression of the lesions. In other cases the lesions may progress to lymphoma.\nConcepts: Polymorphic lymphoproliferative disorder following transplant (Lymphoreticular tumor)\tExcretion Rate From T1 to T2 (Excretion Rate)\tMHC class Ib protein complex (Cell Component)\tPocket erosion (Injury or Poisoning)\tLead Radioisotopes (Lead and lead compound)", + "output": "Polymorphic lymphoproliferative disorder following transplant (Lymphoreticular tumor)" + }, + { + "input": "Definition: Pharmacologic Substance described as heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism.\nConcepts: anti xa (heparin)\tFLOWMETER, CALIBRATION, GAS (Medical Device)\tFF-10101-01 (Pharmacologic Substance)\trecombinant nematode anticoagulant protein c2 (Amino Acid, Peptide, or Protein)\tbotulism (Bacterial infection of the nervous system)", + "output": "anti xa (heparin)" + }, + { + "input": "Definition: Physical findings described as bleeding or escape of blood from a vessel.\nConcepts: regulation of microtubule polymerization (Cell Function)\tZirconium (Zirconium and zirconium compound)\tCarbamohydroxamic acid (Pharmaceutical Preparations)\tMonitoring Systems, Physiologic, Patient Turn Management (Physiologic monitoring system)\tHemorrhages (Central Nervous System)", + "output": "Hemorrhages (Central Nervous System)" + }, + { + "input": "Definition: Substance categorized functionally described as precursor polypeptides which are cleaved to form enzymes.\nConcepts: Right superior pulmonary vein part of pericardial sac (Superior pulmonary vein segment of pericardial sac)\tWD repeat domain 68 (Gene or Genome)\tProenzymes (Enzymes)\tProgesterone Receptor Gene (Nuclear Receptor Gene)\tRadiation Nephropathy (Disease or Syndrome)", + "output": "Proenzymes (Enzymes)" + }, + { + "input": "Definition: Centric heterochromatin described as a small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization.\nConcepts: Alpha-heterochromatin (Centric heterochromatin)\tSINODONTY (Congenital Abnormality)\tCoffea cruda / unroasted coffee (Organic Chemical)\tAnti-CD47/CD19 Bispecific Monoclonal Antibody TG-1801 (Pharmacologic Substance)\tCMDR (Gene or Genome)", + "output": "Alpha-heterochromatin (Centric heterochromatin)" + }, + { + "input": "Definition: something described as a subscale complement to the FACT-G developed specifically for evaluating the quality of life of patients with endometrial cancer.\nConcepts: PQL18-Feel Tired (Intellectual Product)\tACTIVIN A RECEPTOR, TYPE IC (Receptor Serine/Threonine Kinase Gene)\tMongolic Language (Language spoken)\tFunctional Assessment of Cancer Therapy-Endometrial Cancer (Intellectual Product)\tSenile dementia, depressed or paranoid type (nervous system disorder)", + "output": "Functional Assessment of Cancer Therapy-Endometrial Cancer (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving trehalose that occur as a result of a stimulus indicating the organism is under stress.\nConcepts: Vascular Patency (Organ or Tissue Function)\tFAC005-I Feel Sexually Attractive (FACT-B Version 4 Questionnaire Question)\ttrehalose metabolic process involved in response to stress (trehalose metabolic process)\tDNM1L wt Allele (Gene or Genome)\tMain portal vein (Structure of trunk of portal vein)", + "output": "trehalose metabolic process involved in response to stress (trehalose metabolic process)" + }, + { + "input": "Definition: something described as this gene plays a role in lipid transport.\nConcepts: IRINOTECAN (I [Preparations])\tMetaplasia/Hyperplasia (Finding)\tINTRASURGICAL SITE (Functional Concept)\tBeta4Gal-T1 (glycosyltransferase)\tAPOB Gene (Apolipoprotein gene)", + "output": "APOB Gene (Apolipoprotein gene)" + }, + { + "input": "Definition: Cercopithecinae described as a genus of Old World monkeys of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, that inhabits the mountainous regions of Ethiopia. The genus consists of only one species, Theropithecus gelada.\nConcepts: Genus Theropithecus (Mammal)\tcellular response to pheromone (cellular response to organic substance)\tHANDPIECE, CONTRA- AND RIGHT-ANGLE ATTACHMENT, DENTAL (Medical Device)\tETHOXZOLAMIDE (Diuretics)\tTreatment Ongoing (Event Occurrence Indicator)", + "output": "Genus Theropithecus (Mammal)" + }, + { + "input": "Definition: indole described as the malate salt of almotriptan, a sulfonamide triptan with vasoconstrictor activity. Almotriptan selectively binds to and activates serotonin 5-HT 1B and 1D receptors in the central nervous system (CNS), thereby causing cerebral blood vessel constriction. This may lead to pain relief from vascular headaches. Almotriptan may also relieve vascular headaches by preventing the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during a migraine, by reducing extravasation of plasma proteins, and by decreasing the release of other mediators of inflammation from the trigeminal nerve.\nConcepts: Anatomy Qualifiers (Classification)\tParent Wishes to Withdraw From Further Participation in the Study (Clinical or Research Assessment Answer)\talmotriptan malate (Sulfonamides)\tCellophane maculopathy (Retinal Diseases)\tGrade 3 Mucositis oral (Finding)", + "output": "almotriptan malate (Sulfonamides)" + }, + { + "input": "Definition: something described as antibody-independent \"killer cells\" derived from the CD8 T lymphocyte line which, when stimulated by antigen, MHC class I antigen, and interleukin 2, secrete cytolytic pore-forming proteins capable of lysing target cells.\nConcepts: T-Lymphocytes, Cytotoxic (CD8-Positive T-Lymphocytes)\tEthanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime,(Z)-, Mononitrate (Imidazole antifungal)\tAminopropyltransferase (Enzyme)\t6-N-acetyl-LL-2,6-diaminoheptanedioate amidohydrolase activity (Molecular Function)\tsubstrate-independent telencephalic tangential migration (telencephalon cell migration)", + "output": "T-Lymphocytes, Cytotoxic (CD8-Positive T-Lymphocytes)" + }, + { + "input": "Definition: Molecular Function described as the aggregation, arrangement and bonding together of a set of components to form a TRAIL death-inducing signaling complex.\nConcepts: Waiting List (Intellectual Product)\tLiquid Dosage Form (Dosage Form by Physical Form)\tTRAIL death-inducing signalling complex assembly (death-inducing signaling complex assembly)\taquaculture (Food Science and Technology)\tdownregulation of skeletal muscle development (negative regulation of striated muscle tissue development)", + "output": "TRAIL death-inducing signalling complex assembly (death-inducing signaling complex assembly)" + }, + { + "input": "Definition: something described as a ranking of the poisonous nature of an object.\nConcepts: adenine/adenine mispair binding (Genetic Function)\tBodily Pain (Sign or Symptom)\tToxicity Grade (Quantitative Concept)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Blood Culture Media, Automated Test (Medical Device)\tEORTC QLQ-C15-PAL Version 1 - Have You Had Trouble Sleeping (Intellectual Product)", + "output": "Toxicity Grade (Quantitative Concept)" + }, + { + "input": "Definition: Plant described as a plant genus of the family CAMPANULACEAE used medicinally and is a source of LOBELINE.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CCND1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tBed nuclei of the stria terminalis posterior division interfascicular nucleus (Body Part, Organ, or Organ Component)\tPan paniscus Schwarz, 1929 (Nonhuman primate)\tlobelia (Campanulaceae)\thelicobacters (Bacterium)", + "output": "lobelia (Campanulaceae)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of presentation used to represent the quantity of product that is found in a single discrete entity where the pharmaceutical dose form is a type of system.\nConcepts: Basinasal line (Fiat anatomical line of head)\tpositive regulation of actin filament annealing (Cell Function)\tPSA Level Greater than 4 (PSA Level Finding)\tToluene (Cycloalkenes)\tSystem Dosing Unit (Potency Unit)", + "output": "System Dosing Unit (Potency Unit)" + }, + { + "input": "Definition: Manufactured Object described as device for accelerating protons or electrons in closed orbits where the accelerating voltage and magnetic field strength varies (the accelerating voltage is held constant for electrons) in order to keep the orbit radius constant; the radiation produced can be used to investigate objects of atomic and molecular size.\nConcepts: physical science (CRISP Thesaurus)\tDistant (Recurrent disease)\tsynchrotron (Particle Accelerators)\tlactococcus lactis (Streptococcus)\tadenosine synthesis (adenosine metabolic process)", + "output": "synchrotron (Particle Accelerators)" + }, + { + "input": "Definition: something described as the developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.\nConcepts: columnar/cuboidal epithelial cell maturation (epithelial cell maturation)\tStudy Objective Description (Description)\tIDS protein, human (Amino Acid, Peptide, or Protein)\tTEL (Language)\trRNA (guanosine-2'-O-)-methyltransferase activity (rRNA (guanine) methyltransferase activity)", + "output": "columnar/cuboidal epithelial cell maturation (epithelial cell maturation)" + }, + { + "input": "Definition: Health Care Activity described as cooperative actions and ventures among health and health-related groups and organizations intended to improve health outcomes.\nConcepts: SRF 231 (Anti-CD47 Monoclonal Antibody)\tCooperation, Intersectoral (Health Services Administration)\tPigmented epithelioid melanocytoma (Melanocytic tumor of skin)\tHow hard was it to hear when you talked to one other person in a noisy place (Intellectual Product)\tMENTHA ARVENSIS FLOWER OIL (Natural Products)", + "output": "Cooperation, Intersectoral (Health Services Administration)" + }, + { + "input": "Definition: Thrombasthenia described as platelet abnormality characterized by defective clot formation, impaired aggregation, and prolonged bleeding time; other manifestations include nosebleeds, inappropriate bruising, and excessive bleeding.\nConcepts: NEDD4 wt Allele (NEDD4 gene)\tpositive regulation of hindgut contraction (regulation of hindgut contraction)\tEMG - Electromyography (Electrophysiology)\tExhaled breath condensate (Breath)\tGlycoprotein IIb/IIIa defect (Blood Platelet Disorders)", + "output": "Glycoprotein IIb/IIIa defect (Blood Platelet Disorders)" + }, + { + "input": "Definition: something described as problem associated with the device which has been used for an unapproved indication or for an unapproved intended use.\nConcepts: Off-Label Use (Device use issue)\tMONITOR, AIRWAY PRESSURE (Medical Device)\tphosphatidylinositol N-acetylglucosaminyltransferase (Glycosyltransferase Gene)\t1,2 Diacylglycerol Kinase (Amino Acid, Peptide, or Protein)\tPathologic Stage IIIA Gastric Cancer AJCC v8 (Pathologic Stage III Gastric Cancer AJCC v8)", + "output": "Off-Label Use (Device use issue)" + }, + { + "input": "Definition: Plant described as lemon tea tree.\nConcepts: selenocystathionine gamma-lyase activity (carbon-sulfur lyase activity)\tDNA Dependent RNA Polymerase I (Amino Acid, Peptide, or Protein)\tE/A skrn'g slf-dznd bloc 11+ (Laboratory Procedure)\tregulation of nitrogen utilization (Regulation of biological process)\tLeptospermum citratum (J.F.Bailey & C.T.White) Challinor, Cheel & A.R.Penfold (Plant)", + "output": "Leptospermum citratum (J.F.Bailey & C.T.White) Challinor, Cheel & A.R.Penfold (Plant)" + }, + { + "input": "Definition: Metabolic Bone Disease Agents described as the sodium salt of alendronate, a second generation bisphosphonate and synthetic analog of pyrophosphate with bone anti-resorption activity. Alendronate sodium binds to and inhibits the activity of geranyltranstransferase (farnesyl pyrophosphate synthetase), an enzyme involved in terpenoid biosynthesis. Inhibition of this enzyme prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are donor substrates of farnesylation and geranylgeranylation during the post-translational modification of small GTPase signalling proteins, which is important in the process of osteoclast turnover. As a result, osteoclast activity is inhibited and bone resorption and turnover are reduced. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C973\" active clinical trials using this agent.\nConcepts: ALENDRONATE SODIUM (Metabolic Bone Disease Agents)\tStaphylococcus warneri Kloos and Schleifer 1975 (Genus staphylococcus)\tAgrin in Postsynaptic Differentiation (Molecular Function)\tPreimplantation lethality (Abnormality of prenatal development or birth)\tPlant Bacteriology (Occupation or Discipline)", + "output": "ALENDRONATE SODIUM (Metabolic Bone Disease Agents)" + }, + { + "input": "Definition: Lugano Classification Stage II Adult Lymphoma AJCC v8 described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm.\nConcepts: Penile adenocarcinoma (Penis carcinoma)\tNeisseria gonorrhoeae, Penicillinase Negative (Bacterium)\tregulation of endothelial cell activation (Cell Function)\tLugano Classification Stage II Adult Non-Hodgkin Lymphoma AJCC v8 (Lugano Classification Stage II Adult Lymphoma AJCC v8)\tCAL (Monoclonal Antibodies)", + "output": "Lugano Classification Stage II Adult Non-Hodgkin Lymphoma AJCC v8 (Lugano Classification Stage II Adult Lymphoma AJCC v8)" + }, + { + "input": "Definition: endoplasmic reticulum calcium ion homeostasis described as any process that increases the concentration of calcium ions in the endoplasmic reticulum.\nConcepts: Barrett's esophagus with low grade dysplasia (Disease or Syndrome)\tMutS Homolog 3 Protein (Biologically Active Substance)\tendoplasmic reticulum calcium ion concentration elevation (Cell Function)\tRenal pelvis and ureter cancer (Kidney and Ureter Neoplasm)\tdrainage procedure (Therapeutic or Preventive Procedure)", + "output": "endoplasmic reticulum calcium ion concentration elevation (Cell Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: H2O + an N-acyl-L-homoserine lactone <=> H+ + an N-acyl-L-homoserine.\nConcepts: regulation of meiotic DNA double-strand break formation (regulation of macromolecule metabolic process)\tacyl-L-homoserine-lactone lactonohydrolase activity (lactonohydrolase activity)\tReticulocytes (Connective Tissue Cells)\tCommittee to the Director, NCI (Group)\tSlowed Nerve Conduction Velocity, Autosomal Dominant (Autosomal dominant hereditary disorder)", + "output": "acyl-L-homoserine-lactone lactonohydrolase activity (lactonohydrolase activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: choline phosphate + H2O = choline + phosphate.\nConcepts: X-linked intellectual disability Stocco Dos Santos type (Mental Retardation)\tphosphocholine phosphatase activity (Molecular Function)\tcompound (Chemical)\tCommunity Risk Control: Communicable Disease (Finding)\tMGMT-Methylated Glioblastoma (Glioblastoma)", + "output": "phosphocholine phosphatase activity (Molecular Function)" + }, + { + "input": "Definition: Congenital Disorders described as a type of hypothyroidism with congenital onset.\nConcepts: isopropylmeprobamate (Carbamic acid esters, centrally acting muscle relaxants)\tNitro-compound Carcinogen (Classification)\tcretin (Congenital Disorders)\tRight internuclear ophthalmoplegia (Disease or Syndrome)\tDevice Electrical Issue (Medical Device Failure or Malfunction)", + "output": "cretin (Congenital Disorders)" + }, + { + "input": "Definition: something described as an acute form of hepatic steatosis.\nConcepts: Up (Spatial Concept)\tWHODAS 2.0 36-item Version Interviewer-administered - Describes Main Work Status Best (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tCytochrome P450, Family 2, Subfamily D, Polypeptide 6*20 Allele (CYP2D6 gene)\t2-(4-Hydroxyphenyl)-3-methyl-1-[4-(2-piperidin-1-ylethoxy)benzyl]-1H-indol-5-ol Hydrochloride (Pharmacologic Substance)\tAcute hepatic steatosis (Disease or Syndrome)", + "output": "Acute hepatic steatosis (Disease or Syndrome)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Tumor Marker described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid (typically serum) to detect the levels of one or more substances (typically proteins) secreted by breast cancer or induced/repressed in surrounding tissues by the presence of breast cancers. These assays are typically used as an aid in determining the likelihood that a patient has breast cancer, particularly in patients with suspicious findings by diagnostic imaging (i.e., mammography).\nConcepts: IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Breast Cancer (Medical Device)\tGestational Trophoblastic Tumor pTX TNM Finding v7 (Gestational Trophoblastic Tumor Pathologic Primary Tumor TNM Finding v7)\tDTPACLR (Laboratory Procedure)\tPULM VENTILATION (respiratory system function)\tFosfocina (Organophosphonates)", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Breast Cancer (Medical Device)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how satisfied or dissatisfied an individual is or was with how naturally their reconstructed breasts sits and hangs.\nConcepts: VAP-B (Gene or Genome)\tAccountable Party Identifier (Intellectual Product)\tSatisfaction with How Naturally Your Reconstructed Breasts Sits and Hangs (Intellectual Product)\themocyte development (Cell Function)\tEGFR p.Gly719Ala (EGFR NP 005219.2:p.G719X)", + "output": "Satisfaction with How Naturally Your Reconstructed Breasts Sits and Hangs (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: L-lysine = D-lysine.\nConcepts: lysine racemase activity (amino-acid racemase activity)\tBRAF NP 004324.2:p.Gly469Ala (Cell or Molecular Dysfunction)\tChildhood disintegrative disor (Developmental regression)\tBromosuccinimide (Indicator, Reagent, or Diagnostic Aid)\tmycotoxin metabolic process (Molecular Function)", + "output": "lysine racemase activity (amino-acid racemase activity)" + }, + { + "input": "Definition: something described as this gene is involved in signal transduction.\nConcepts: HAMD-21 - Work and Activities (Intellectual Product)\tVena sublingualis (Structure of tributary of lingual vein)\tG protein-coupled receptor kinase 2-like (Gene or Genome)\tp68 (Gene or Genome)\tDay Times Kilogram per Milliliter (Measurement Unit Description)", + "output": "G protein-coupled receptor kinase 2-like (Gene or Genome)" + }, + { + "input": "Definition: C-SSRS Children's Baseline Questionnaire Question described as columbia-Suicide Severity Rating Scale Children's Baseline - Total number of actual attempts.\nConcepts: Neopolitan Mastiff dog (Working Breed)\tNanomole per 24 Hours (Unit of Amount of Substance Rate)\tCSS0609 (Intellectual Product)\tTIRABRUTINIB (Organic Chemical)\tGrade 4 Stenosis of gastrointestinal stoma (Stenosis of Gastrointestinal Stoma, CTCAE)", + "output": "CSS0609 (Intellectual Product)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 - Physical Well-Being: Subscale score.\nConcepts: FAC071-Physical Subscale Score (FACIT-F Version 4 Questionnaire Question)\tEricale (Plant)\ttaurine-2-oxoglutarate transaminase activity (Molecular Function)\tREG ALLOSTERIC (Biochemical Phenomena)\tbetaine hcl (B [Preparations])", + "output": "FAC071-Physical Subscale Score (FACIT-F Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Fetal arrhythmia described as an abnormality in the fetal heart rhythm associated with an increase in fetal heart rate above 160 beats per minute.\nConcepts: beta-Alanylhistidine (C [Preparations])\tCalendula officinalis / pot marigold (Pharmacologic Substance)\tSOWSB1 (Clinical or Research Assessment Questionnaire)\tFetal Tachyarrhythmia (Rate and rhythm disorders NEC)\tOG (Occipital lobe)", + "output": "Fetal Tachyarrhythmia (Rate and rhythm disorders NEC)" + }, + { + "input": "Definition: Behavior described as behaviors indicating ability to take care of personal needs, function socially, and control problem behavior. Primarily used for disabled or disordered populations.\nConcepts: LIFE STYLE (Life Style)\tPREVOTELLA RUMINICOLA (Bacterium)\tBehavior, Adaptive (Behavior)\tdyshematopoietic; anemia (Disease or Syndrome)\tPerformed Product Investigation Result Defect Type Code (Intellectual Product)", + "output": "Behavior, Adaptive (Behavior)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of concentration equal to milligrams per milliliter, divided by milligrams per day.\nConcepts: Wax Dosage Form (Biomedical or Dental Material)\tExocanthion (Body Location or Region)\turinary tract transplantation (Therapeutic or Preventive Procedure)\tEcological System, Closed (Human-caused Phenomenon or Process)\tmg/mL/(mg/day) (Unit of concentration)", + "output": "mg/mL/(mg/day) (Unit of concentration)" + }, + { + "input": "Definition: Phenothiazines described as a phenothiazine used as an antipsychotic agent and as an antiemetic.\nConcepts: upregulation of type IV fimbria biogenesis (Cell Function)\tOrth solution (Indicator, Reagent, or Diagnostic Aid)\tNursing Education (Curricula)\t2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine (Organic Chemical)\tGenetically-engineered Immune Cell (Gene Therapy Agent)", + "output": "2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine (Organic Chemical)" + }, + { + "input": "Definition: Organic Chemical described as a centrally acting muscle relaxant. Its mode of action is unknown.\nConcepts: 1,2-Propanediol, 3-(4-chlorophenoxy)- (Organic Chemical)\tjuncii/deng xin cao (Oriental herbs and natural substances letter J)\tBlood drawing chair, device (Chairs)\tImmunogenicity Study (Clinical Trial Type)\tmercurius precipitatus ruber (Pharmacologic Substance)", + "output": "1,2-Propanediol, 3-(4-chlorophenoxy)- (Organic Chemical)" + }, + { + "input": "Definition: Finding described as an increased amount of tooth display when smiling compared to rest position.\nConcepts: Renal Pelvis and Ureter Cancer Clinical TNM Finding v8 (Renal Pelvis and Ureter Cancer TNM Finding v8)\tABCG Proteins (Amino Acid, Peptide, or Protein)\tHighlighted Indicator (Qualitative Concept)\tIncreased incisal display on smiling (Finding of mouth region)\tHaloperidol product (piperidine)", + "output": "Increased incisal display on smiling (Finding of mouth region)" + }, + { + "input": "Definition: organophosphate metabolic process described as the chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism.\nConcepts: BEST'S CARMINE (Indicator, Reagent, or Diagnostic Aid)\tNURF complex (ISWI-type complex)\tanti-sigma factor activity (transcription corepressor activity)\tLip and Oral Cavity Cancer (Malignant neoplasm of mouth)\tfructose 6-phosphate metabolism (phosphate-containing compound metabolic process)", + "output": "fructose 6-phosphate metabolism (phosphate-containing compound metabolic process)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3.0 Young Adult Report (PedsQL Neuromuscular Module Version 3.0 Young Adult Report) In the past one month, how much of a problem has this been for you: It is hard for my family to plan activities like vacations.\nConcepts: Testicular Cancer pT3 TNM Finding v8 (Testicular Cancer Pathologic Primary Tumor TNM Finding v8)\tPQL11-Hard to Gain/Lose Weight (Intellectual Product)\tLeft ventricular area fractional change (Feature of left ventricle)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard for Family to Plan Activities (Intellectual Product)\tERT - Fear Responded as Neutral (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard for Family to Plan Activities (Intellectual Product)" + }, + { + "input": "Definition: something described as a hamster derived from a cross between a Chinese hamster and Syrian hamster.\nConcepts: Papillary-Basaloid Carcinoma of the Penis (papillary carcinoma of penis)\tManagement of concentration of parenteral nutrition (Therapeutic or Preventive Procedure)\tQIDSR106 (Intellectual Product)\tAPROSULATE SODIUM (Organic Chemical)\tCHINESE SYRIAN (Mammal)", + "output": "CHINESE SYRIAN (Mammal)" + }, + { + "input": "Definition: Biologically Active Substance described as cyclic AMP-dependent transcription factor ATF-4 (351 aa, ~39 kDa) is encoded by the human ATF4 gene. This protein plays a role in the regulation of gene transcription.\nConcepts: 2-Amino-4-Pentenoic Acid (Allyl Compounds)\tMoore fracture (Fracture dislocation of wrist joint)\tETRP01-Medication Total Points (Intellectual Product)\tsensory system, gustatory (subcortical sensory systems)\tCyclic AMP-Responsive Element-Binding Protein 2 (Amino Acid, Peptide, or Protein)", + "output": "Cyclic AMP-Responsive Element-Binding Protein 2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.\nConcepts: MMSE - Repeat Word 3 (Intellectual Product)\tSEMINAL VESICLES (Structure of male genital duct)\tup regulation of kinase activity (positive regulation of transferase activity)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MSH6 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\t8: 109330128-109283148 (Spatial Concept)", + "output": "up regulation of kinase activity (positive regulation of transferase activity)" + }, + { + "input": "Definition: peptide hormone described as pituitary hormones are produced by the pituitary gland, the master gland of the endocrine system which is located at the base of the brain. Levels of pituitary hormones are regulated by the hypothalamus, anterior and posterior lobes of the pituitary gland, and by the pars intermedia.\nConcepts: Clinical Opiate Withdrawal Scale Questionnaire (Clinical or Research Assessment Questionnaire)\tGordonia (Gordoniaceae)\tMidshaft hypospadias (Hypospadias)\tPituitary Hormone (Hypothalamic and pituitary hormone, NOS)\tEstrogen Receptor Positive by Immunohistochemistry (ESR1 Status by Immunohistochemistry)", + "output": "Pituitary Hormone (Hypothalamic and pituitary hormone, NOS)" + }, + { + "input": "Definition: ADNI-AVLT Questionnaire Question described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 2, Word 2.\nConcepts: osmoregulated periplasmic glucan formation (osmoregulated periplasmic glucan metabolic process)\tAvailablibility (UML Entity)\tEnuresis (Signs and Symptoms)\tisoproterenol (Non-selective beta-adrenoreceptor agonists for systemic use)\tAVL01019 (Intellectual Product)", + "output": "AVL01019 (Intellectual Product)" + }, + { + "input": "Definition: NAD(P)H dehydrogenase complex assembly described as the aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I.\nConcepts: pneumovirus (unclassified Pneumoviridae)\tAcid-Base Balance (METABOLISM: GENERAL TERMS)\tPhosphatidylinositol-4,5-Bisphosphate 3-Kinase 110 kDa Catalytic Subunit Alpha Protein Variant (Cell or Molecular Dysfunction)\tNADH dehydrogenase complex (plastoquinone) assembly (Molecular Function)\tSkeletal dysplasia with intellectual disability syndrome (Hereditary disorder of musculoskeletal system)", + "output": "NADH dehydrogenase complex (plastoquinone) assembly (Molecular Function)" + }, + { + "input": "Definition: Substance categorized by disposition described as agents used in the treatment of malaria. They are usually classified on the basis of their action against plasmodia at different stages in their life cycle in the human.\nConcepts: Paresis, Muscular (Disease or Syndrome)\tanti malarials (Substance categorized by disposition)\tInferior mesenteric arterial subdivision (Systemic artery)\tMass spectrometry measurement, NOS (Laboratory Procedure)\tnails thicken (Thickness of nail - finding)", + "output": "anti malarials (Substance categorized by disposition)" + }, + { + "input": "Definition: Finding described as a morphologic finding indicating the presence of a cellular infiltrate associated with fibrosis in a tissue sample.\nConcepts: GP2250 (Pharmacologic Substance)\tForaminifera (Eukaryote)\tMalignt tumor lacrimal gland (Neoplasm by body site)\tDecreased blood lysine (Finding)\tINFILTRATE/FIBROSIS (Finding)", + "output": "INFILTRATE/FIBROSIS (Finding)" + }, + { + "input": "Definition: Physical shape described as a morphologic finding that refers to a structure that consists of a central vessel surrounded by tumor cells. This cell-vessel structure is contained in a cystic space. It is found in approximately 50% of yolk sac tumors.\nConcepts: QS-FACT-L Version 4 TEST (Intellectual Product)\tSchiller-Duval Body (Physical shape)\toxidoreduction coenzyme metabolic process (coenzyme metabolic process)\tPrimary Graft Failure (Graft Rejection)\tReceptor Tyrosine-Protein Kinase erbB-1 S752 I759del (Cell or Molecular Dysfunction)", + "output": "Schiller-Duval Body (Physical shape)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Bladder Version 4 (FACT-BL Version 4) Additional Concerns: It burns when I urinate.\nConcepts: Collagen III Neo-Peptide C3M (Laboratory Procedure)\tribonuclease mitochondrial RNA processing complex (small nucleolar ribonucleoprotein complex location)\tFAC00635 (Intellectual Product)\tPhenol Compound (cyclic alcohol)\tempathy (Individual Behavior)", + "output": "FAC00635 (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as the reemergence of thyroid gland anaplastic carcinoma after a period of remission.\nConcepts: Recurrent Oropharyngeal Throat Undifferentiated Carcinoma (Oropharyngeal lymphepithelioma)\tRecurrent Thyroid Gland Undifferentiated (Anaplastic) Carcinoma (Neoplastic Process)\tCMP-N-acetylneuraminate biosynthetic process (nucleotide-sugar biosynthetic process)\tTrichosanthes (Plant)\tcholesterinum/cholesterine (Organic Chemical)", + "output": "Recurrent Thyroid Gland Undifferentiated (Anaplastic) Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a language used for describing molecular patterns and properties.\nConcepts: Uveal Melanoma Pathologic Distant Metastasis TNM Finding v8 (Finding)\tAmphipodas (Subphylum Crustacea)\tRNF5 protein, human (Biologically Active Substance)\tSMARTS (Intellectual Product)\tAnti-Immunizing Neoantigen Peptide Antibody (Amino Acid, Peptide, or Protein)", + "output": "SMARTS (Intellectual Product)" + }, + { + "input": "Definition: heterocycle biosynthetic process described as the chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.\nConcepts: negative regulation of termination of RNA polymerase II transcription, poly(A)-coupled (Genetic Function)\tAccumulation (Finding)\tN-terminal peptidyl-proline dimethylation involved in translation (N-terminal peptidyl-proline dimethylation)\thistidine anabolism (alpha-amino acid biosynthetic process)\tNM 002524.4:c.181 183delCAAinsAAG (Cell or Molecular Dysfunction)", + "output": "histidine anabolism (alpha-amino acid biosynthetic process)" + }, + { + "input": "Definition: Fibrosis described as a slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.\nConcepts: QS-TSCYC TESTCD (CDISC Questionnaire Terminology)\tUHDR1-Maximal Chorea: LLE (Intellectual Product)\tormond's disease (Retroperitoneal fibrosis)\tembryonic semicircular canal morphogenesis (tube morphogenesis)\tCOMPONENT, CAST (Medical Device)", + "output": "ormond's disease (Retroperitoneal fibrosis)" + }, + { + "input": "Definition: something described as the most posterior point on the spine of the palatine bone.\nConcepts: Tip of posterior nasal spine (Anatomical point)\tINGLIFORIB (Organic Chemical)\tIVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis A, Antigen (Medical Device)\tAllogeneic Anti-CD19 CAR-T Cells CTX110 (Allogeneic Lymphocyte)\tClass I Restoration (Restoration of tooth)", + "output": "Tip of posterior nasal spine (Anatomical point)" + }, + { + "input": "Definition: Miscellaneous Occupation described as a class of professional or vocational positions of employment that involve office or administrative support.\nConcepts: Stage 4 Hepatoblastoma (Neoplastic Process)\tTime of Reference Time Point (Time)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Deletion, 15q11.2-q13 (Medical Device)\tOffice and Administrative Support (Occupation or Discipline)\tOesophageal squamous cell carcinoma site unspecified recurrent (Neoplastic Process)", + "output": "Office and Administrative Support (Occupation or Discipline)" + }, + { + "input": "Definition: Nitrogen and nitrogen compound described as a pyridine, pyrazine, and piperazine derivative that is used as a HYPNOTIC AND SEDATIVE in the treatment of INSOMNIA.\nConcepts: Hose Line Device (Manufactured Object)\t(+)-Zopiclone (Nitrogen and nitrogen compound)\tMetatarsal osteolysis (Osteolysis involving bones of the feet)\tKERATITIS, AUTOSOMAL DOMINANT (Disease or Syndrome)\tSpontaneous Otoacoustic Emissions (Hearing)", + "output": "(+)-Zopiclone (Nitrogen and nitrogen compound)" + }, + { + "input": "Definition: something described as the date and time that the summary information about the conclusions of the clinical study are submitted to a structured, publicly accessible, Web-based results database, such as the ClinicalTrials.gov results database.\nConcepts: alpha-conotoxin MI (Amino Acid, Peptide, or Protein)\tRecurrent hand flapping (Mental or Behavioral Dysfunction)\tResults Posting Date (Temporal Concept)\tNeocallimastigale (Chytridiomycota)\tIL-17A production (interleukin-17 production)", + "output": "Results Posting Date (Temporal Concept)" + }, + { + "input": "Definition: Monomorphic Post-Transplant Lymphoproliferative Disorder described as the reemergence of monomorphic post-transplant lymphoproliferative disorder after a period of remission.\nConcepts: oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor (oxidoreductase activity, acting on other nitrogenous compounds as donors)\tLow salt syndrome (Hyposmolality syndrome)\tRecurrent Monomorphic Post-Transplant Lymphoproliferative Disorder (Recurrent Lymphoproliferative Disorder)\tKiller Cell Lectin-Like Receptor Subfamily B (Receptor)\tManic State (Emotional states)", + "output": "Recurrent Monomorphic Post-Transplant Lymphoproliferative Disorder (Recurrent Lymphoproliferative Disorder)" + }, + { + "input": "Definition: something described as a wrist joint polymer constrained prosthesis is a device made of polyester-reinforced silicone elastomer intended to be implanted to replace a wrist joint. This generic type of device consists of a single flexible across-the-joint component that prevents dislocation in more than one anatomic plane.\nConcepts: Prostheses, Wrist, Constrained, Polymer (Medical Device)\tL-gulono-1,4-lactone dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor)\tModerately Differentiated Invasive Breast Carcinoma (Invasive Breast Carcinoma by Histologic Grade)\tocclusion by symbiont of host xylem (occlusion by symbiont of host vascular system)\tMusculoskeletal chest pain due to costochondritis (Musculoskeletal chest pain)", + "output": "Prostheses, Wrist, Constrained, Polymer (Medical Device)" + }, + { + "input": "Definition: Trunk of cranial nerve described as the second cranial nerve.\nConcepts: Blood Stem Cell Transplantation, Umbilical Cord (Therapeutic or Preventive Procedure)\tage-dependent general metabolic decline involved in chronological cell aging (Organism Function)\tCranial Nerve II (Trunk of cranial nerve)\tfungiform papilla morphogenesis (Morphogenesis)\tGastric Synovial Sarcoma (Malignant Gastric Soft Tissue Neoplasm)", + "output": "Cranial Nerve II (Trunk of cranial nerve)" + }, + { + "input": "Definition: C-SSRS Children's Baseline Questionnaire Question described as columbia-Suicide Severity Rating Scale Children's Baseline - Did you ever do anything to try to kill yourself or make yourself not alive anymore? What did you do? Did you ever hurt yourself on purpose? Why did you do that?\nConcepts: Clips, Surgical, Wound Closure, Skin/Tissue Suturing (Medical Device)\tCSS06-Actual Attempt (C-SSRS Children's Baseline Questionnaire Question)\tnuclear matrix proteins (Nuclear Proteins)\t10E6 Organisms/mL (Unit of Arbitrary Substance Concentration)\tX-linked intellectual disability, microcephaly, testicular failure syndrome (x-linked intellectual disability)", + "output": "CSS06-Actual Attempt (C-SSRS Children's Baseline Questionnaire Question)" + }, + { + "input": "Definition: Abnormality of the crus of the helix described as extension of the ridge of the crus helix across the ear and connection of the crus to the antihelix.\nConcepts: SYSTEM,TEST,(IHC),TUMOR MARKER,MONITORING,BLADDER CANCER (Medical Device)\tLocally Advanced Malignant Paraganglioma (Neoplastic Process)\tCrus of helix connected to antihelix (Anatomical Abnormality)\tIntrinsic Tongue Muscle Vertical Component (Body Part, Organ, or Organ Component)\tCHART-SF Interview Version - Nights Away From Home Last Year (CHART-SF Interview Version Questionnaire Question)", + "output": "Crus of helix connected to antihelix (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as oligosaccharide comprised of a galactose molecule and sucrose bound together with an alpha 1-6 linkage.\nConcepts: polynucleotide 5'-hydroxyl kinase (phosphorylating) activity (Molecular Function)\tD-Raffinose (R [Preparations])\tesophagus; duplication (Congenital Abnormality)\tEET (Organic Chemical)\tUbiquitin Specific Peptidases (Enzyme)", + "output": "D-Raffinose (R [Preparations])" + }, + { + "input": "Definition: Temporal Qualifier described as the period of time between two dates or events or between the beginning and end of something.\nConcepts: Mastication, function (Digestive System Processes)\tlisdexamfetamine dimesylate (amphetamine)\tRecognition, Facial Identity (Visual Perception)\tTime Frame (Temporal Concept)\tdovitinib (Organic Chemical)", + "output": "Time Frame (Temporal Concept)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the MLL/CASC5 fusion gene. This protein is comprised of the N-terminal half of the histone-lysine N-methyltransferase MLL protein, including the AT hook DNA binding domain and the DNA methyltransferase domain, fused to the C-terminal coiled-coil domain of protein CASC5.\nConcepts: Inhibition of Amyloidogenesis (Molecular Function)\tVulvar Clear Cell Hidradenocarcinoma (Sweat gland adenocarcinoma)\tHistone-Lysine N-Methyltransferase MLL/Protein CASC5 Fusion Protein (Amino Acid, Peptide, or Protein)\tFunctional Assessment of Cancer Therapy-Breast Version 4 Questionnaire (Intellectual Product)\tAlcohol Related Neurodevelopmental Disorder (Disease or Syndrome)", + "output": "Histone-Lysine N-Methyltransferase MLL/Protein CASC5 Fusion Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: PCL-5 Questionnaire Question described as the PTSD Checklist for DSM-5 - In the past month, how much were you bothered by: Having strong physical reactions when something reminded you of the stressful experience (for example, heart pounding, trouble breathing, sweating)?\nConcepts: Tl binding (signaling receptor binding)\tPKS enzyme (Multienzyme Complexes)\tadoptive transfer (Therapeutic or Preventive Procedure)\tPCL01-Strong Physical Reactions (PCL-5 Questionnaire Question)\tALISTIPES SHAHII (Alistipes)", + "output": "PCL01-Strong Physical Reactions (PCL-5 Questionnaire Question)" + }, + { + "input": "Definition: Family Erwiniaceae described as a genus of gram-negative, rod-shaped bacteria in the family ENTEROBACTERIACEAE. They exist only as primary endosymbionts of five species of TSETSE FLIES, found in specialized organelles called mycetomes. The bacteria supply crucial B vitamins (VITAMIN B COMPLEX) which the flies require for fertility.\nConcepts: Wigglesworthia (Bacterium)\tislets langerhan (Islets of Langerhans)\tStage III Colon Cancer AJCC v8 (Neoplastic Process)\tAssesses readiness to learn based (Intervention regimes)\tchemical compounds (Substance)", + "output": "Wigglesworthia (Bacterium)" + }, + { + "input": "Definition: something described as s-phase onset is controlled, so that it occurs only once every cell cycle. DNA is licensed for replication after mitosis in G(1), and passage through S-phase removes the license to replicate. Licensing factors are required for licensing and central to ensuring that replication occurs once per cell cycle. (from J Biol Chem 2001 Nov 30;276(48):44905-11)\nConcepts: Menthol Flavor (Structured Product Labeling Flavor)\tBotulinum Toxin Type Cd (Hazardous or Poisonous Substance)\tLicensing Factor (DNA Replication Initiation Protein)\tGrade 2 Neonatal Culture Positive Sepsis, Adverse Event (Neonatal Culture Positive Sepsis, Adverse Event)\tPlatinum-Based (General Qualifier)", + "output": "Licensing Factor (DNA Replication Initiation Protein)" + }, + { + "input": "Definition: something described as human GRB10 wild-type allele is located within 7p12-p11.2 and is approximately 203 kb in length. This allele, which encodes growth factor receptor-bound protein 10, plays a role in the modulation of signaling from both insulin and insulin-like receptor tyrosine kinases.\nConcepts: Grb-10 (Gene or Genome)\tEF5 (Hydrocarbons, Halogenated)\tHospitals--Drug distribution systems (Medical Device)\tMIR9-1 Pre-miRNA (pre-miRNA)\txanthine:xanthine oxidase activity (Molecular Function)", + "output": "Grb-10 (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(5;12)(q31;p13) which fuses the 5' portion of the ACSL6 gene and the 3' portion of the ETV6 gene. In a patient with acute myelogenous leukemia with eosinophilia, this rearrangement fused exons 1-9 of the ACSL6 gene to either intron 2 or exon 3 of the ETV6 gene and does not produce a fusion protein. In one patient with refractory anemia with excess blasts with basophilia, this rearrangement fused exon 19 of the ACSL6 gene with a site within exon 1 of the ETV6 gene and could result in the production of a fusion protein.\nConcepts: C5a, des-Arginine Complement (Amino Acid, Peptide, or Protein)\tX-ray crystallography (X-Ray Diffraction)\tCharts, Eye, Visual Acuity (Ophthalmological equipment)\tUnilateral polymicrogyria (Disease or Syndrome)\tFACL6/ETV6 Fusion Gene (Fusion Gene)", + "output": "FACL6/ETV6 Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Skin Neoplasms described as a rare but aggressive type of basal skin carcinoma. It is characterized by the presence of a meshwork of stellate tumor cells. It occurs most commonly in the nose and ears.\nConcepts: HSP (Heat shock proteins)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TTN (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tSkin Adamantinoid Basal Cell Carcinoma (Skin Neoplasms)\tMIF Measurement (Laboratory Procedure)\tDDS0107 (Intellectual Product)", + "output": "Skin Adamantinoid Basal Cell Carcinoma (Skin Neoplasms)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.\nConcepts: negative regulation of CD8-positive, alpha-beta T cell proliferation (negative regulation of CD8-positive, alpha-beta T cell activation)\tberubicin hydrochloride (Organic Chemical)\tLOWER EXTREMITY MUSCLE CRAMP (Movement Disorders)\t5 alpha-Dihydrotestosterone (Testosterone and testosterone derivative)\tIntermittent lactic acidemia (Disease or Syndrome)", + "output": "negative regulation of CD8-positive, alpha-beta T cell proliferation (negative regulation of CD8-positive, alpha-beta T cell activation)" + }, + { + "input": "Definition: vertebral augmentation procedure described as procedures to restore vertebrae to their original shape following vertebral compression fractures by inflating a balloon inserted into the vertebrae, followed by removal of the balloon and injection of BONE CEMENTS to fill the cavity.\nConcepts: Melanoma of the Conjunctiva Clinical Primary Tumor TNM Finding v7 (Finding)\tSusceptibility to viral and mycobacterial infection (Primary immune deficiency disorder)\tPyrometer (Gauge or Meter Device)\ttolosa-hunt syndrome (Disease or Syndrome)\tBalloon Vertebroplasty (vertebral augmentation procedure)", + "output": "Balloon Vertebroplasty (vertebral augmentation procedure)" + }, + { + "input": "Definition: Quantitative Concept described as natural number unit of measurement for a portion of a particular type of cell (excluding white blood cell subtypes) per 100 white blood cells.\nConcepts: hormone resistance (Finding)\t/100 WBC (Quantitative Concept)\tGlomerular Filtration Rate from Creatinine and Urea Nitrogen Adjusted for Body Surface Area Measurement (Glomerular Filtration Rate)\tSISTER, HALF (Sister)\tATPase-coupled monosaccharide transmembrane transporter activity (Molecular Function)", + "output": "/100 WBC (Quantitative Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as the presence of air or gas within the cranial cavity.\nConcepts: SCOPULARIOPSIS (Fungus)\tmultifactor translation initiation factor (eIF) complex (ribonucleoprotein complex location)\tUNCOUPLING PROTEIN 1 (Gene or Genome)\tfetal heart tones (Fetal heart sounds present)\tPneumocephalus (Brain Diseases)", + "output": "Pneumocephalus (Brain Diseases)" + }, + { + "input": "Definition: something described as a benign tumor of the pancreas with morphologic characteristics of endocrine, acinar and ductal cells.\nConcepts: alpha,alpha-trehalose phosphorylase (configuration-retaining) activity (glucosyltransferase activity)\tColorectal Tubular Adenoma (Tubular adenoma)\tACINAR-ISLET CELL TUMOR, BENIGN (Experimental Organism Neoplasm)\tADL0104 (ADCS-ADL Questionnaire Question)\tSIP - Sickness impact profile (Assessment scales)", + "output": "ACINAR-ISLET CELL TUMOR, BENIGN (Experimental Organism Neoplasm)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a transmembrane domain-containing matrix metalloproteinase. It is synthesized as an inactive zymogen that is activated by the proteolytic action of PROPROTEIN CONVERTASES. Matrix metalloproteinase 16 plays a direct role in the cleavage of proteins in the pericellular environment. In addition, it can function indirectly by enzymatically activating the proprotein form of other MATRIX METALLOPROTEINASES such as the zymogen of MATRIX METALLOPROTEINASE 2.\nConcepts: MMP-X2 Protein (Amino Acid, Peptide, or Protein)\tCutaneous Fibrocytic Neoplasm (Skin lesion)\tEosinophilic Myelocyte Count (Complete Blood Count)\tOmeprazole magnesium (O [Preparations])\tMerkel Cell Carcinoma Clinical Primary Tumor TNM Finding v8 (Merkel Cell Carcinoma Clinical TNM Finding v8)", + "output": "MMP-X2 Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Idea or Concept described as an article used to connect words, phrases, or clauses representing alternatives; used to connect alternative terms for the same thing; used in correlation; used to correct or rephrase what was previously said; otherwise.\nConcepts: Blinding Schema (Research Activity)\tor - article (RelationshipConjunction - CodeSystem)\tBenign Soft Tissue Tumor of the CNS (Benign neurologic neoplasms)\tGrants and Contracts, NIH (Funding)\tAlveolar arch of maxilla (Upper jaw region)", + "output": "or - article (RelationshipConjunction - CodeSystem)" + }, + { + "input": "Definition: Cell Function described as the cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur.\nConcepts: lobular neoplasia (Mammary Neoplasms)\tzygotene (Cell Function)\tIncreased erythrocyte protoporphyrin concentration (Abnormal circulating porphyrin concentration)\tFox Chase Cancer Center (NCI-Designated Comprehensive Cancer Center)\tHerding Breed (Mammal)", + "output": "zygotene (Cell Function)" + }, + { + "input": "Definition: Motor Neuron Disease described as a motor neuron disease marked by progressive weakness of the muscles innervated by cranial nerves of the lower brain stem. Clinical manifestations include dysarthria, dysphagia, facial weakness, tongue weakness, and fasciculations of the tongue and facial muscles. The adult form of the disease is marked initially by bulbar weakness which progresses to involve motor neurons throughout the neuroaxis. Eventually this condition may become indistinguishable from AMYOTROPHIC LATERAL SCLEROSIS. Fazio-Londe syndrome is an inherited form of this illness which occurs in children and young adults. (Adams et al., Principles of Neurology, 6th ed, p1091; Brain 1992 Dec;115(Pt 6):1889-1900)\nConcepts: Secondary Cerebral Hodgkin's Disease (Neoplastic Process)\tPENILE CANCER, CARCINOMA, EPIDERMOID (cellular diagnosis, penile cancer)\ttaxusin 2-alpha-hydroxylase activity (Molecular Function)\tprogressive bulbar palsy (Disease or Syndrome)\tRETINOBLASTOMA-LIKE 2 (Gene or Genome)", + "output": "progressive bulbar palsy (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a genus of gram-negative bacteria isolated from individuals in LONG-TERM CARE facilities and HOSPITALS.\nConcepts: endocardial cushion to mesenchymal transition involved in cardiac skeleton development (endocardial cushion to mesenchymal transition)\tSea Blue Histiocytosis (Qualitative abnormality of granulocyte)\tSNAI2 (Transcription Repressor/Corepressor Gene)\tProteus vulgaris (Bacterium)\tRNU, Rat Strain (Common Rattus Norvegicus Strains)", + "output": "Proteus vulgaris (Bacterium)" + }, + { + "input": "Definition: something described as a country in western Europe, comprising islands, including England, Scotland, Wales, and the northern one-sixth of the island of Ireland, between the North Atlantic Ocean and the North Sea, northwest of France.\nConcepts: DLCO % REF (Diagnostic Procedure)\tRecombinant Humanized IgG1k Monoclonal Antibody TRC093 (Amino Acid, Peptide, or Protein)\tunited kingdom (Europe)\tMembrane, Chorioallantoic (Extraembryonic membranes)\tRenal Cell Carcinoma (Intellectual Product)", + "output": "united kingdom (Europe)" + }, + { + "input": "Definition: Medical Device described as surgical retractors designed to temporarily separate and hold back the edges of abdomino-perineal surgical incisions, exposing and/or giving access to the rectum stump. Rectum perineal retractors usually consist of large, handheld manual instruments with two large curved blades at the distal end and two scissors-like handles with a ratchet that permits self-retention. Rectum retractors are used mainly in surgical procedures for excision of the rectum; other dedicated retractors intended to expand the natural anal canal and rectum are usually classified as rectal specula.\nConcepts: IVD Test Reagent/Kits, Serology, Parasite (IVD Test Reagent/Kits, Serology)\tRectum Retractors (Retractors, Surgical)\tMBDTC (Temporal Concept)\tKit Dosing Unit (Unit dose)\tHigh Grade Prostatic Intraepithelial Neoplasia, Foamy Variant (Neoplastic Process)", + "output": "Rectum Retractors (Retractors, Surgical)" + }, + { + "input": "Definition: polynucleotide 5'-hydroxyl-kinase activity described as catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA.\nConcepts: DNA kinase activity (polynucleotide 5'-hydroxyl-kinase activity)\t8q21-q24 (Chromosome band)\tCOLD (Respiratory System Finding)\tLives with Sibling (Finding)\tSuperoxide Radical (Peroxides)", + "output": "DNA kinase activity (polynucleotide 5'-hydroxyl-kinase activity)" + }, + { + "input": "Definition: regulation of translation described as translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation.\nConcepts: adenylyl cyclase binding (Molecular Function)\tmethylmalonic acidemia (Disorder of propionate AND/OR methylmalonate metabolism)\tBlack cumin (Plant)\ttranslational attenuation (regulation of translation)\tBiomedical Computing (Biomedical Occupation or Discipline)", + "output": "translational attenuation (regulation of translation)" + }, + { + "input": "Definition: Reproductive process described as the deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males.\nConcepts: down regulation of plasmacytoid dendritic cell antigen processing and presentation (regulation of plasmacytoid dendritic cell antigen processing and presentation)\tBead (Spatial Concept)\tcopulatory plug deposition (Social Behavior)\ttriethanolamine metabolism (cellular amine metabolic process)\tSpaniards (Population Group)", + "output": "copulatory plug deposition (Social Behavior)" + }, + { + "input": "Definition: Organism Function described as the process in which an organism effects a change in the structure or function of a symbiont organism, mediated by secretion of lectins which bind to the bacterial surface. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.\nConcepts: lectin-induced modified bacterial internalization (interaction with symbiont)\tpalliative care for terminal disease (Care regime)\tCortex Radix (Plant Part)\tcell lining (Biospecimen)\tPectinatus Lee et al. 1978 (Approved Lists 1980) emend. Caldwell et al. 2013 (Selenomonadaceae)", + "output": "lectin-induced modified bacterial internalization (interaction with symbiont)" + }, + { + "input": "Definition: something described as a heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.\nConcepts: NOXA-BCL-xl complex location (Cell Component)\tdown-regulator of transcription 1, TBP-binding (TBP Inhibitor Gene)\tRetrospective Study (Research Activity)\tMultifunctional Electrodes, Pacing/Defibrillation (Medical Device)\tStudy Site Oversight Status Effective Date Range (Temporal Concept)", + "output": "NOXA-BCL-xl complex location (Cell Component)" + }, + { + "input": "Definition: antigen sampling in mucosal-associated lymphoid tissue described as the process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue.\nConcepts: Recurrent Intrahepatic Cholangiocarcinoma (Recurrent Liver Carcinoma)\tdeoxynivalenol biosynthetic process (Molecular Function)\tfirst patient treated - identity (Intellectual Product)\tantigen sampling by dendritic cells in mucosal-associated lymphoid tissue (antigen sampling in mucosal-associated lymphoid tissue)\tFinding of valgus deformity of great toe (Disorder of toe)", + "output": "antigen sampling by dendritic cells in mucosal-associated lymphoid tissue (antigen sampling in mucosal-associated lymphoid tissue)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the antibody to any member of the genus Aspergillus in a biological specimen.\nConcepts: monovalent cation:proton antiporter activity (Molecular Function)\tTachyarrhythmias (including supraventricular and ventricular tachyarrhythmias) (Classification)\tASPERGILLUS ANTIBODY (Laboratory Procedure)\tcarbon carbon lyase (Lyase)\tFungi, Filamentous (Cell Count)", + "output": "ASPERGILLUS ANTIBODY (Laboratory Procedure)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder characterized by the body's inability to metabolize galactose. This type of galactosemia is caused by germline mutations in the GALT gene which leads to the inhibition in the activity of the enzyme galactose-1-phosphate uridyl transferase.\nConcepts: Set of left maxillary periodontal ligaments (Body Part, Organ, or Organ Component)\tTransferase Deficiency Galactosemia (Disease or Syndrome)\tS-adenosyl-L-methionine:(S)-corytuberine-N-methyltransferase activity (Molecular Function)\taccepting (General Qualifier)\tunidentified bacterium (Organism)", + "output": "Transferase Deficiency Galactosemia (Disease or Syndrome)" + }, + { + "input": "Definition: Persons described as the child who is not wanted by one or both parents.\nConcepts: Condensed nuclear chromosome (Nuclear chromosome)\tUnwanted children (Persons)\tFusion Protein rHSA/GCSF (Recombinant Colony-Stimulating Factors)\tHigh Grade Lung Neuroendocrine Neoplasm (Neoplastic Process)\tSKR5 (Receptor)", + "output": "Unwanted children (Persons)" + }, + { + "input": "Definition: Thyroid Neoplasm described as a teratoma that involves, is continuous with, or completely replaces the thyroid gland. It is derived from all three embryonic germ cell layers. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as benign (grade 0 or 1), immature (grade 2), and malignant (grade 3). Grade 0 teratomas contain only mature elements; grade 1 teratomas have a limited degree of immaturity; grade 2 teratomas have a more extensive degree of immaturity; grade 3 teratomas are composed exclusively of immature tissues. The prognosis depends on patient age, tumor size, and grade.\nConcepts: SMDDS115 (SMDDS Version 1.0 Questionnaire Question)\tMultiple Myeloma Surgery (Therapeutic or Preventive Procedure)\tX-linked intellectual disability and epilepsy with progressive joint contracture and facial dysmorphism syndrome (Disease or Syndrome)\tThyroid Gland Teratoma (Neoplastic Process)\tpMX Melanoma of Skin (Finding)", + "output": "Thyroid Gland Teratoma (Neoplastic Process)" + }, + { + "input": "Definition: Free upper limb region described as distal free upper limb region, each instance of which consists of some carpus, metacarpus and set of digits.\nConcepts: prehippocampal rudiment (Body Part, Organ, or Organ Component)\tCYP24A1 wt Allele (Gene or Genome)\tHand, NOS (Body Part, Organ, or Organ Component)\tCongenital large intestinal atresia (Congenital absence, atresia and stenosis of large intestine, part unspecified)\tunplannedTreatmentIndicator (Functional Concept)", + "output": "Hand, NOS (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Organism Function described as the chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.\nConcepts: Pregnancy, abdominal (Ectopic Pregnancy)\tAbout As Socially Active As Before (Clinical or Research Assessment Answer)\tJunction Device (Device Component or Accessory)\tExocrine Pancreatic Cancer pM1 TNM Finding v6 (Finding)\tacetate ester metabolism (Organism Function)", + "output": "acetate ester metabolism (Organism Function)" + }, + { + "input": "Definition: Reticuloendothelial System described as a type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.\nConcepts: Macrophage, Bone Marrow-Derived (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS: GENERAL TERMS)\tRetractors, Surgical, Eye, Orbital (Medical Device)\textrinsic to intraperoxisomal membrane (extrinsic component of organelle membrane)\tansamycin biosynthetic process (organonitrogen compound biosynthetic process)\tsuccinate membrane transport (carboxylic acid transmembrane transport)", + "output": "Macrophage, Bone Marrow-Derived (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS: GENERAL TERMS)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"no\" to Question 36 above, was your child's activity limited by: Pain?\nConcepts: Integrin, Alpha X (Antigen CD11C (p150), Alpha Polypeptide) Gene (ITGAX gene)\tPODCI2-Outdoor Limited by: Pain (Intellectual Product)\tHB-EGF (Biologically Active Substance)\tMinute Times Microgram per Milliliter per Meter Squared (Measurement Unit Description)\tPURPURA NEONATAL (Purpuras)", + "output": "PODCI2-Outdoor Limited by: Pain (Intellectual Product)" + }, + { + "input": "Definition: Organ with organ cavity described as organ with organ cavity, which consists of an arborizing set of tubular organ parts, the walls of which are continuous and surround a continuous lumen. Examples: systemic arterial tree (organ), tracheobronchial tree, biliary tree.\nConcepts: IntraduodenalRoute (Functional Concept)\tADL02-Usual Physically Dressing Perform (Intellectual Product)\tregulation of meiotic metaphase/anaphase transition (regulation of meiotic chromosome separation)\tHollow tree organ (Body Part, Organ, or Organ Component)\tmegacolon congenital (Colonic Diseases)", + "output": "Hollow tree organ (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Myopathy described as a disorder of muscle unrelated to impairment of innervation or neuromuscular junction.\nConcepts: muscular disease (MYOSITIC DISORDERS)\tHYPRLN (Protein or Enzyme Type Measurement)\tBuccalMucosaRoute (Functional Concept)\tScapuloperoneal Syndrome, X-Linked (Muscular Dystrophy)\tAllogeneic GM-CSF-secreting Tumor Vaccine PANC 10.05 pcDNA-1/GM-Neo (Cell)", + "output": "muscular disease (MYOSITIC DISORDERS)" + }, + { + "input": "Definition: Professional or Occupational Group described as workers who install, repair, or replace a variety of electrical equipment in telecommunications, transportation, utilities, and other industries.\nConcepts: upregulation of VSMC proliferation (positive regulation of smooth muscle cell proliferation)\tLMO2 Protein (Amino Acid, Peptide, or Protein)\tvoltage-gated potassium channel activity involved in AV node cell action potential repolarization (voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization)\tElectrical and Electronic Equipment Mechanics, Installers, and Repairers (Miscellaneous Occupation)\tCalcium signaling pathway (Functional Concept)", + "output": "Electrical and Electronic Equipment Mechanics, Installers, and Repairers (Miscellaneous Occupation)" + }, + { + "input": "Definition: Ampulla of Vater Cancer Pathologic Primary Tumor TNM Finding v7 described as ampulla of Vater cancer with a finding of carcinoma in situ.\nConcepts: IIEF0103 (Intellectual Product)\tTarget Study Population (Population Group)\t3' transitive RNA interference (transitive RNA interference)\tAmpulla of Vater Cancer pTis TNM Finding v7 (Finding)\tPossess (Property or Attribute)", + "output": "Ampulla of Vater Cancer pTis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Toddler Parent Report - In the past 7 days, how much of a problem has this been for your child: My child feels tired.\nConcepts: PQL18-Feel Tired (Intellectual Product)\tCounseling about nutrition using social learning theory approach (Therapeutic or Preventive Procedure)\tRetinoblastoma pM1e TNM Finding v7 (Finding)\tGAIA Level 1 Placental Abruption (GAIA Antenatal Bleeding Level of Diagnostic Certainty)\tthyroid uptke T3 orT4 ea.tst (General blood analysis)", + "output": "PQL18-Feel Tired (Intellectual Product)" + }, + { + "input": "Definition: something described as a measurement of the pepsinogen II in a biological specimen.\nConcepts: Pepsinogen II Measurement (Laboratory Procedure)\tHigh grade prostatic intraepithelial neoplasia (Prostate cancer pathology)\tCarbamoyl-beta-methylcholine (Cholinergic Muscarinic Agonist [EPC])\tChemokine Ligand 24 (Laboratory Procedure)\tCimicifugae racemosae Rhizoma (Pharmacologic Substance)", + "output": "Pepsinogen II Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + H(+) + NADPH.\nConcepts: 2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tImplantable Pacemaker Analyzers, Intraoperative (Tester device)\tfungal biofilm matrix (Extracellular Polymeric Substance Matrix)\tEnterococcus durans (ex Sherman and Wing 1937) Collins et al. 1984 (Enterococcus)\tCVRFTDTC (Temporal Concept)", + "output": "2-dehydro-3-deoxy-D-gluconate:NADP+ 6-oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Conditioning described as learning by associating a stimulus (the cause) with a particular outcome (the effect).\nConcepts: Lophocebus (Mammal)\tPolymicrogyria Gene Deletion/Duplication Reagents (Medical Device)\tDRRI1K01 (DRRI-2 Questionnaire Question)\tMammary Gland Type Features Present (Finding)\tConditionings, Classical (Learning)", + "output": "Conditionings, Classical (Learning)" + }, + { + "input": "Definition: Respiratory region of nose described as the most anterior part of the nasal cavity, lined by squamous epithelium.\nConcepts: sulfox-cide (Hazardous or Poisonous Substance)\tNasal vestibule (Respiratory region of nose)\tMICROCEPHALY-DEAFNESS SYNDROME (hearing impairment)\tXanthomonas vesicatoria (ex Doidge 1920) Vauterin et al. 1995 (Xanthomonas)\thematopoietic marrow (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS)", + "output": "Nasal vestibule (Respiratory region of nose)" + }, + { + "input": "Definition: Associated Persons Domain described as a domain utilized for the submission of subject status records related to persons associated with the study subject.\nConcepts: Associated Persons Subject Status (Associated Persons Domain)\tBCL-1 Gene Amplification (Gene Amplification Abnormality)\tH1299 Tumor Cell Lysate Vaccine (Pharmacologic Substance)\tHigh Blood Pressures (Non-Cancer Diagnosis)\tCardiac Beat Detected (Instrument Data)", + "output": "Associated Persons Subject Status (Associated Persons Domain)" + }, + { + "input": "Definition: something described as a plant genus of the family SALICACEAE. Members contain casearins which are clerodane-type DITERPENES.\nConcepts: Papulosquamous Lesion (Finding)\tsecretory dimeric IgA immunoglobulin complex location (dimeric IgA immunoglobulin complex)\tPowder Diffractometer (Instrument - device)\tUHDR1-Dysarthria (Intellectual Product)\tCasearia Jacq., 1760 (Plant)", + "output": "Casearia Jacq., 1760 (Plant)" + }, + { + "input": "Definition: something described as unit of arbitrary substance concentration (biologic activity concentration) defined as the concentration of one millionth of international unit per one milliliter of system volume.\nConcepts: HYPOTENSION POSTURAL (Blood pressure finding)\tSyndrome withdrawal (Withdrawal and rebound effects)\tmilliinternational unit/litre (uIU per unit volume)\tBody Surface Area Formula for Cats (Quantitative Concept)\tANAE (Reagents)", + "output": "milliinternational unit/litre (uIU per unit volume)" + }, + { + "input": "Definition: Electrophoresis described as separation technique in which a sample is introduced into a capillary tube and the components are separated by the application of high voltage.\nConcepts: SYSTEM, ENVIRONMENTAL CONTROL, POWERED (Medical Device)\tGPRC1F (GRM6 gene)\tSteering Committee (Population Group)\tNortriptyline-containing product (amitriptyline)\tFractionation, Capillary Electrophoresis (Electrophoresis)", + "output": "Fractionation, Capillary Electrophoresis (Electrophoresis)" + }, + { + "input": "Definition: something described as a question about whether an individual can easily swallow liquids or soft foods.\nConcepts: Hiatal Hernias (Lesion of stomach)\tGrade 4 Clear Cell Renal Cell Carcinoma (Conventional (Clear Cell) Renal Cell Carcinoma)\tGrade 1 Voice alteration (Finding)\tCan Easily Swallow Liquid or Soft Food (Intellectual Product)\tPartial superior movement of thyroid cartilage with minimal approximation of arytenoids to epiglottic petiole (Finding)", + "output": "Can Easily Swallow Liquid or Soft Food (Intellectual Product)" + }, + { + "input": "Definition: Enzyme described as a family of enzymes that catalyze the stereoselective, regioselective, or chemoselective syn-dehydrogenation reactions. They function by a mechanism that is linked directly to reduction of molecular OXYGEN.\nConcepts: Fatty Acid Desaturase (Mixed Function Oxygenases)\tFACT-L Version 4 - I Have Nausea (Intellectual Product)\t17: 35109922-35138436 (Chromosome 17 Physical Location)\tregulation of root morphogenesis (regulation of root development)\tpositive regulation of gastrin-induced gastric acid secretion (Biologic Function)", + "output": "Fatty Acid Desaturase (Mixed Function Oxygenases)" + }, + { + "input": "Definition: something described as breast cancer with tumor size more than 0.1 cm, but not more than 0.5 cm in greatest dimension.\nConcepts: Outpatient Commitment (Health Services, Outpatient)\tdeoxyribokinase activity (phosphotransferase activity, alcohol group as acceptor)\tBBS (Disease or Syndrome)\tGrade 2 Infant Sedation, Adverse Event (Infant Sedation, Adverse Event)\tBreast Cancer pT1a TNM Finding v6 (Finding)", + "output": "Breast Cancer pT1a TNM Finding v6 (Finding)" + }, + { + "input": "Definition: Kinins described as a family of biologically active peptides sharing a common conserved C-terminal sequence, -Phe-X-Gly-Leu-Met-NH2, where X is either an aromatic or a branched aliphatic amino acid. Members of this family have been found in mammals, amphibians, and mollusks. Tachykinins have diverse pharmacological actions in the central nervous system and the cardiovascular, genitourinary, respiratory, and gastrointestinal systems, as well as in glandular tissues. This diversity of activity is due to the existence of three or more subtypes of tachykinin receptors.\nConcepts: metacyclogenesis (Organism Function)\tAbnormal number of incisors (Abnormality of the incisor)\tTachykinins (Kinins)\tMAF (Gene or Genome)\tPlanned Activity Repeat Frequency Range Max Code (Repeat Frequency Range Max Code)", + "output": "Tachykinins (Kinins)" + }, + { + "input": "Definition: Cyclohexanes described as monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.\nConcepts: Cyclohexanols (Hexanols)\tplasma membrane raft polarization (plasma membrane raft distribution)\thexadecatetraenoic acid (Polyunsaturated Fatty Acids)\tHyperplasia, basal cell (Hyperplasia)\tDNR-expressing nasopharyngeal carcinoma-specific cytotoxic T lymphocytes (therapeutic autologous lymphocytes)", + "output": "Cyclohexanols (Hexanols)" + }, + { + "input": "Definition: something described as the portion of the central zone of the prostate that is located to the anatomical right of center.\nConcepts: AMP-224 (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tCSS02-Most Severe Ideation, Control (Intellectual Product)\tGDP catabolism (Molecular Function)\t4: 76912750-76861526 (Spatial Concept)\tCentral zone of right half prostate (Central zone of prostate)", + "output": "Central zone of right half prostate (Central zone of prostate)" + }, + { + "input": "Definition: Health Care Activity described as the patient will remain in a basic hospital environment for a brief time.\nConcepts: Colon Neuroendocrine Tumor G2 (Colorectal Neuroendocrine Tumor G2)\tIL-4 production (Organism Function)\tOther Establishment Activity (Administration occupational activities)\tShort Term General Hospital (Health Care Activity)\tgadoxetic acid disodium (Magnetic resonance imaging contrast media)", + "output": "Short Term General Hospital (Health Care Activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a potent protein tyrosine kinase inhibitor that exhibits greater specificity for c-ErbB oncoprotein.\nConcepts: Tyrphostin A30 (Tyrphostin Compound)\tIVD Panels, Human Genetics, Metabolic Disorder, Myopathy, Comprehensive (IVD Panels, Human Genetics, Metabolic Disorder)\tper-protocol analysis set (Data Set)\tPushing (Physiologic Function)\tADCS-ADL - Talk About Events Outside of Home that Subject Took Part In (Intellectual Product)", + "output": "Tyrphostin A30 (Tyrphostin Compound)" + }, + { + "input": "Definition: Diagnostic radioisotope described as a gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.\nConcepts: Biomechanics Platforms (Electromechanical Devices)\tTechnetium Tc^99c^ sulphur colloid (Radioconjugate)\tModerately Comfortable (Finding)\tPhosphates, Calcium (calcium)\tMLNS (Examiner's Diagnosis)", + "output": "Technetium Tc^99c^ sulphur colloid (Radioconjugate)" + }, + { + "input": "Definition: something described as catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O.\nConcepts: vertical transmission (Infectious transmissions)\ttyrosine 3-monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)\tFACT-LEU Version 4 - I Feel Nervous (FACT-LEU Version 4 Questionnaire Question)\tCerebellar oedema (Central Nervous System)\tTSCC - Feeling Scared of Women (TSCC Questionnaire Question)", + "output": "tyrosine 3-monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as high dose rate radiation delivered by a radiation source contained in an intra-vaginal cylinder to target neoplasms in or surrounding the vaginal canal.\nConcepts: NCPDP Strength Unit of Measure Terminology (Intellectual Product)\tThyroid Stimulating Hormone Receptor Antibody (Laboratory Procedure)\tHDR-IVB (Therapeutic or Preventive Procedure)\tHilar Lung Tumor (location of neoplasm of lung)\tintegral component of mitochondrial inner membrane (integral component of mitochondrial membrane)", + "output": "HDR-IVB (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the pyramidal shaped part of the temporal bone located at the base of the skull between the sphenoid and occipital bones.\nConcepts: Enhanced Level of Genomic Instability 1 Homolog (Hydrolase)\tProduct containing oblimersen (Antisense Oligonucleotides)\tStructure of petrous part of temporal bone (Zone of temporal bone)\tChildhood Small Intestinal Leiomyosarcoma (Childhood Leiomyosarcoma)\tStage IIA1 Cervical Cancer (Neoplastic Process)", + "output": "Structure of petrous part of temporal bone (Zone of temporal bone)" + }, + { + "input": "Definition: Alcohols described as slightly viscous, colorless and odorless liquid cyclic ether. Glycidol is used as a stabilizer for natural oils and vinyl polymers, as an alkylating agent, a sterilant, a demulsifier, a dye-leveling agent and it is also used as an intermediate in the synthesis of glycerol, glycidyl ethers and amines. Exposure to Glycidol irritates the skin, eyes, and mucous membranes and depresses the central nervous system in humans. Glycidol induces mutations in human lymphocytes and is reasonably anticipated to be a human carcinogen.\nConcepts: 20: 1823425-1868537 (Chromosome 20 Physical Location)\tOtic Cream Dosage Form (Cream)\tExcessive vitamin B12 intake (Excessive vitamin intake)\tOxiranylmethanol (Organic Chemical)\tAd5-yCD/mutTK(SR39)rep-ADP (Pharmacologic Substance)", + "output": "Oxiranylmethanol (Organic Chemical)" + }, + { + "input": "Definition: Cell described as a preparation of natural killer T-cells (NKTs) expressing an invariant (alpha, beta) T-cell receptor (iNKTs), with potential immunomodulating and antineoplastic activities. Upon infusion of the therapeutic iNKTs, these cells recognize CD1d-restricted lipid ligands, which are expressed on certain tumor cells, and secrete large amounts of various cytokines. This may activate the immune system against tumor cells. Additionally, iNKTs directly target and lyse tumor cells.\nConcepts: Mercurius nitrosus / mercury nitrate (Homeopathic remedies letter M)\tregulation ofMyD88-dependent TLR signaling pathway (regulation of toll-like receptor signaling pathway)\tTherapeutic iNK T-cells (therapeutic autologous lymphocytes)\tST Segment Duration Aggregate (ECG Measurement)\tYeasts (Fungal material)", + "output": "Therapeutic iNK T-cells (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: Peripheral Nerves described as a nerve which originates in the sacral spinal cord (S2 to S4) and innervates the PERINEUM, the external GENITALIA, the external ANAL SPHINCTER and the external urethral sphincter. It has three major branches: the perineal nerve, inferior anal nerves, and the dorsal nerve of penis or clitoris.\nConcepts: Translational Cell Therapy Shared Resource (Health Care Related Organization)\tGrade 2 Hydrocephalus (Hydrocephalus, CTCAE)\tdown regulation of protein localization to mitotic spindle pole body (regulation of protein localization to mitotic spindle pole body)\tNerve, Pudendal (Branch of sacral plexus)\tPersonhood (Ethics)", + "output": "Nerve, Pudendal (Branch of sacral plexus)" + }, + { + "input": "Definition: response to folic acid described as the directed movement of a motile cell or organism in response to the presence of folate.\nConcepts: AUTOMATISM (Neurologic Deficits)\tSerum Chemistry Measurement (Blood Chemistry Measurement)\tMyocardial scintigraphy (Diagnostic Procedure)\tchemotaxis to folate (response to folic acid)\tmovement along microtubule (cytoskeleton-dependent intracellular transport)", + "output": "chemotaxis to folate (response to folic acid)" + }, + { + "input": "Definition: Meningomyelocele/myelocele described as herniation of spinal cord tissue and meninges through a defect in the thoracic region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.\nConcepts: Thoracic myelocele (Meningomyelocele/myelocele)\tFeminisation (Abnormal development of secondary sexual characteristics)\tDovitinib Lactate (Antineoplastic Enzyme Inhibitor)\tPROSTATE CANCER-ASSOCIATED PROTEIN 8 (Gene or Genome)\tTracheitis (Tracheal Diseases)", + "output": "Thoracic myelocele (Meningomyelocele/myelocele)" + }, + { + "input": "Definition: Finding by Cause described as any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment. an adverse event (AE) can therefore be any unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of a medicinal (investigational) product, whether or not related to the medicinal (investigational) product. NOTE: For further information, see the ICH Guideline for Clinical safety Data Management: Definitions and standards for expedited Reporting. [After ICH E2A] See also serious adverse event, serious adverse experience.\nConcepts: Promyelocyte (Leukocytes)\tAdverse event NOS (Pathologic Function)\tAging, Cell (Aging)\tThymic Germ Cell Tumor T2 TNM Finding (Finding)\tProstheses, Periodontal (Dental Prosthesis)", + "output": "Adverse event NOS (Pathologic Function)" + }, + { + "input": "Definition: something described as a benign well-circumscribed tumor composed of mature adipocytes, characterized by areas of abundant fibrous tissue.\nConcepts: fibrolipoma (Lipoma)\tPlott hound (Hound)\tAbdominal Soft Tissue Necrosis (Musculoskeletal and Connective Tissue Disorders, CTCAE)\tTSCYC1-Not Wanting to Eat Certain Foods (TSCYC Questionnaire Question)\tendosome fission (organelle fission)", + "output": "fibrolipoma (Lipoma)" + }, + { + "input": "Definition: Special Histology Staining Method described as this is an all-round useful stain for many things, including glycogen, mucin, mucoprotein, glycoprotein, as well as fungi. The reaction is based on the oxidation of glycol group to aldehydes by periodate. The schiff's reagent selectively stains the aldehydes to a rose pink color. PAS is useful for outlining tissue structures--basement membranes, capsules, blood vessels, etc.\nConcepts: dysphasia (Physical findings)\tactin filament-based movement (actin filament-based process)\tsarmoxicillin (penicillins)\tDystonic movements (Brain Diseases)\tPAS Staining Method (Microbial staining)", + "output": "PAS Staining Method (Microbial staining)" + }, + { + "input": "Definition: something described as ultra-low vision but with retained ability to identify a moving object (typically hand motion at distance of 30 cm).\nConcepts: European Union Notified Body (Population Group)\tUltra-low vision with retained motion projection (Ultra-low vision)\tamyloid beta (A4) precursor protein-binding, family A, member 1 (Gene or Genome)\tLarge Cell Neuroendocrine Carcinoma of the Ovary (Large cell neuroendocrine carcinoma)\tCarfilzomib/Lenalidomide/Dexamethasone Regimen (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "Ultra-low vision with retained motion projection (Ultra-low vision)" + }, + { + "input": "Definition: Exposure Dose described as the planned total amount of challenge agent to which the subject is exposed at one time.\nConcepts: 1H-Pyrazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione (Chemical categorised functionally)\tIVD Test Reagent/Kits, Serology, Bacteria, Brucella abortus, IgG Antibody (Medical Device)\tCCNE Gene Mutation (Gene Mutant)\tPlanned Challenge Agent Exposure (Quantitative Concept)\tBreakthrough Pain (Episodic pain)", + "output": "Planned Challenge Agent Exposure (Quantitative Concept)" + }, + { + "input": "Definition: something described as displacement of the 3rd finger towards the radial side (i.e., towards the thumb).\nConcepts: StudyExecution (study design, planning, execution, and result)\tKiloelectronvolt (Unit of energy)\tAbsent/small big toe (Abnormality of the hallux)\tRadial deviation of the 3rd finger (Anatomical Abnormality)\td.ug/ml/(mg/kg) (Quantitative Concept)", + "output": "Radial deviation of the 3rd finger (Anatomical Abnormality)" + }, + { + "input": "Definition: Obstetric monitoring described as the act of observing and recording the fetal heart rate for determining the baseline values or other abnormal findings.\nConcepts: gamma tocopherols (tocopherol)\tIVD Test Reagent/Kits, Multimodal Assay, Gene Anomaly/Immunoassay/Immunocytochemistry-Immunohistochemistry/Serology (IVD Test Reagent/Kits, Multimodal Assay)\tAbnormality of the fascia (Anatomical Abnormality)\tG6PDRBC (Cell Count)\tFetal heart monitoring (Fetal procedure)", + "output": "Fetal heart monitoring (Fetal procedure)" + }, + { + "input": "Definition: Hemoglobin A described as an adult hemoglobin component normally present in hemolysates from human erythrocytes in concentrations of about 3%. The hemoglobin is composed of two alpha chains and two delta chains. The percentage of HbA2 varies in some hematologic disorders, but is about double in beta-thalassemia.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Hepatitis A, IgG Antibody (Medical Device)\tblood vessel endothelial cell fate commitment (Cell Function)\tHEMOGLOBIN AA 02 (Hemoglobin)\tarea FD gamma of Bonin-1947 (Body Location or Region)\ttumor necrosis factor superfamily cytokine production (Organism Function)", + "output": "HEMOGLOBIN AA 02 (Hemoglobin)" + }, + { + "input": "Definition: something described as the Small Molecule Screening Shared Resource is dedicated to provide Cancer Center members with access to high throughput screening of structurally-diverse, drug-like chemicals in appropriate biological assays. The resource provides screening and liquid handling equipment, informatics for data handling and analysis, assay design expertise, centralized storage of compound libraries and develops new methodologies for screening of small molecule agents that inhibit cancer phenotypes in cellular or animal models.\nConcepts: Araucaria Juss., 1789 (Araucariaceae)\tPROTOONCOGENE HOMOLOGOUS TO MYELOCYTOMATOSIS VIRUS (MYC Family Genes)\tSmall Molecule Screening Shared Resource (Health Care Related Organization)\tcellular response to muramyl dipeptide (cellular response to drug)\tacetates (Fatty Acids, Volatile)", + "output": "Small Molecule Screening Shared Resource (Health Care Related Organization)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Level 3 Assessment of Provider-Initiated Preterm Delivery is defined by three criteria: first, the patient is determined to be between 24 0/7 and 36 6/7 weeks gestation; second, from recall, the patient reports that there were no signs or symptoms of spontaneous onset of preterm labor; third, from recall, the patient reports that the healthcare provider indicated the need to induce labor or to perform a cesarean delivery between, resulting in preterm delivery.\nConcepts: Product containing irritant (Hazardous or Poisonous Substance)\tphosphothreonine residue binding (Molecular Function)\tLevel 3 Assessment of Provider-Initiated Preterm Delivery (Intellectual Product)\tNardostachys (Plant)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(2;5)(p23;q35) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)", + "output": "Level 3 Assessment of Provider-Initiated Preterm Delivery (Intellectual Product)" + }, + { + "input": "Definition: Individual Behavior described as avoiding risks that can lead to physical injury or harm. Avoiding potentially hazardous situations such as misusing fire or running into traffic.\nConcepts: Looking after one's safety (Individual Behavior)\tHomeobox Protein CDX-2 (Biologically Active Substance)\tCervical cancer recurrent (Recurrent Female Reproductive System Carcinoma)\tStage IIIB Primary Peritoneal Cancer (Stage III Primary Peritoneal Cancer AJCC v8)\tSickle Cell Nephropathy (Renal vascular disorder)", + "output": "Looking after one's safety (Individual Behavior)" + }, + { + "input": "Definition: Neural Tube Defects described as a rare neural tube closure defect characterised by an abnormally low lying conus which is tethered by a lumbosacral lipomatous mass (containing fatty tissue, nerve fibres, meningeal strands and fibrous bands) which engulfs the filum terminale and varying numbers of dorsal and ventral nerve root components, typically producing sensory, motor, bowel and/or bladder dysfunction. Cutaneous stigmata, absent or reduced reflexes and foot deformities (for example talipes cavovalgus) are frequently present.\nConcepts: glucose-6-phosphate inositol monophosphate cycloaldolase activity (intramolecular lyase activity)\tAGMODIFY (Name)\tSmall Proline-Rich Protein 2A Gene (Gene or Genome)\tSTAPHYLOCOCCUS AUREUS, PENICILLINASE POSITIVE (Bacterium)\tLeptomyelolipoma (Neural Tube Defects)", + "output": "Leptomyelolipoma (Neural Tube Defects)" + }, + { + "input": "Definition: Inorganic Chemical described as otopic compound of hydrogen of mass 2 (deuterium) with oxygen; used to study mechanisms and rates of chemical or nuclear reactions, as well as biological processes.\nConcepts: DULoxetine hydrochloride (Thiophenes)\tCapillary Leak Syndrome (Vascular Disorders, CTCAE)\tCane Corso (Mammal)\tdeuterium oxide (HYDROGEN, OXYGEN AND WATER)\tTobacco Use, Combined Prevention/Cessation Research (Research Activity)", + "output": "deuterium oxide (HYDROGEN, OXYGEN AND WATER)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus.\nConcepts: High Absorption Reticulocytes to Total Reticulocytes Ratio Measurement (Laboratory Procedure)\tChapman reflex treatment method (Therapeutic or Preventive Procedure)\tresponse to ultrasound (Organism Function)\tAcute myeloid leukemia with t(6;9)(p23;q34); DEK-NUP214 (Neoplastic Process)\tWHODAS 2.0 12-item Version Proxy-administered - Emotionally Affected by Health (WHODAS 2.0 12-item Version Proxy-administered Questionnaire Question)", + "output": "response to ultrasound (Organism Function)" + }, + { + "input": "Definition: Mental disorder in childhood described as a rare disorder characterized by episodes of excessive sleep and behavioral alterations while awake. It affects predominantly males. The individuals exhibit normal behavior between episodes.\nConcepts: head measurements (Skinfold Thickness)\tKleine Levin Hibernation Syndrome (Syndrome)\tactivation of diorcinol biosynthesis (positive regulation of cellular biosynthetic process)\tBuformin Hydrochloride (biguanide)\tURINARY BLADDER (Body Part, Organ, or Organ Component)", + "output": "Kleine Levin Hibernation Syndrome (Syndrome)" + }, + { + "input": "Definition: Enzyme described as a cytochrome P450 enzyme family that occurs in insects. Its members function in the metabolism of XENOBIOTICS.\nConcepts: Percent Recovered Infinity Predicted Normalized by Weight (Quantitative Concept)\tFetal megacystis (Congenital genitourinary tract anomalies NEC)\tCytochrome P450 Family 6 (Enzyme)\tMIP 1alpha (Macrophage Inflammatory Proteins)\tMood equilibrium (Personal health status)", + "output": "Cytochrome P450 Family 6 (Enzyme)" + }, + { + "input": "Definition: anterior/posterior pattern specification, imaginal disc described as the establishment, maintenance and elaboration of the anterior/posterior axis of the genital disc. An anterior and posterior compartment form in each of the three genital disc primoridia (the female genital disc primordium, the male genital disc primordium and the anal primordium).\nConcepts: biomedical equipment development (Biomedical Occupation or Discipline)\tIVD Test Reagent/Kits, Serology, Parasite, Giardia lamblia, Antibody (IVD Test Reagent/Kits, Serology, Parasite, Giardia Species, Antibody)\tMobitz (Type) II Atrioventricular Block (Conduction Abnormality and Atrioventricular Heart Block, CTCAE)\thPARP-2 (DNA repair protein)\tgenital disc anterior/posterior pattern formation (genital disc pattern formation)", + "output": "genital disc anterior/posterior pattern formation (genital disc pattern formation)" + }, + { + "input": "Definition: Pregnancy described as UTERINE BLEEDING from a GESTATION of less than 20 weeks without any CERVICAL DILATATION. It is characterized by vaginal bleeding, lower back discomfort, or midline pelvic cramping and a risk factor for MISCARRIAGE.\nConcepts: malandrinum/horse grease (Pharmacologic Substance)\tRPTOR (Gene or Genome)\tOcular Adnexal Lymphoma Pathologic Primary Tumor TNM Finding v8 (Ocular Adnexal Lymphoma Pathologic TNM Finding v8)\tABORTION THREATENED (Hemorrhage in early pregnancy)\tNerve excision (Operative procedure on nerve)", + "output": "ABORTION THREATENED (Hemorrhage in early pregnancy)" + }, + { + "input": "Definition: Finding described as soft tissue sarcoma of the abdomen and thoracic visceral organs with tumor invading another organ.\nConcepts: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT3 TNM Finding v8 (Finding)\tVisual Analogue Well Being Scale (Research or Clinical Assessment Tool)\tPresence of terminal O-fucose glycans on properdin (Abnormal fucosylation of O-linked protein glycosylation)\tOvarian Mucinous Carcinoid Tumor (Ovarian Carcinoid Tumor)\tBloom Syndrome c.2207 2212delATCTGAinsTAGATTC (BLM Gene Mutation)", + "output": "Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT3 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as a keratoprosthesis is a device made of plastic intended to be implanted to replace the central area of an opacified natural cornea of the eye to maintain or restore sight.\nConcepts: 1p35.1-p36.23 (Cell Component)\tFACT-B Version 4 - I Have a Lack of Energy (FACT-B Version 4 Questionnaire Question)\tCross-Sectional Surveys (Epidemiologic Studies)\tReg Track Doc (Document type)\tKERATOPROSTHESIS, TEMPORARY IMPLANT, SURGICAL USE (Medical Device)", + "output": "KERATOPROSTHESIS, TEMPORARY IMPLANT, SURGICAL USE (Medical Device)" + }, + { + "input": "Definition: Movement described as movement produced voluntarily by the patient.\nConcepts: contused (Traumatic abnormality by mechanism)\tActive motion (Musculoskeletal Physiological Phenomena)\tScience of Medicine (Authorized Osteopathic Thesaurus)\tTSCYC110 (TSCYC Questionnaire Question)\tviral inhibition of host pattern recognition receptor activity (suppression by virus of host receptor activity)", + "output": "Active motion (Musculoskeletal Physiological Phenomena)" + }, + { + "input": "Definition: Finding described as oral intervention indicated\nConcepts: Ubiquitin Ligase Protein PHF9 (Enzyme)\tDeoxyuridine (Hematinics)\tMental Health Recovery (Rehabilitation therapy)\tThiazines (Heterocyclic Compounds, 1-Ring)\tGrade 2 Stoma site infection (Stoma Site Infection, CTCAE)", + "output": "Grade 2 Stoma site infection (Stoma Site Infection, CTCAE)" + }, + { + "input": "Definition: Finding described as eyelid carcinoma with distant metastasis.\nConcepts: Software, Physiologic Recording, Temperature (Software, Physiologic Recording)\tasparagine transmembrane transport (asparagine transport)\tAbnormality of blood circulation (Abnormal cardiovascular system physiology)\tTorpid (Psychomotor energy)\tEyelid Carcinoma cM1 TNM Finding v8 (Eyelid Carcinoma Clinical Distant Metastasis TNM Finding v8)", + "output": "Eyelid Carcinoma cM1 TNM Finding v8 (Eyelid Carcinoma Clinical Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: Mydriatics described as an ester with sympathomimetic activities. Dipivefrin hydrochloride is a prodrug of epinephrine that, due to its greater lipophilicity, allows for better penetration into the anterior chamber. Once inside the eye, dipivefrin hydrochloride is converted by hydrolysis to epinephrine. Epinephrine enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. This leads to a reduction in intraocular pressure.\nConcepts: Pass-Throughs (Medical Device)\tLumbar Sympathetic Nerve Trunk (Autonomic Nervous System Part)\tdipivefrin HCl (dipivefrin)\thFOG-2 (ZFPM2 gene)\tNZR, Rat Strain (Mammal)", + "output": "dipivefrin HCl (dipivefrin)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in both ubiquitination and signaling.\nConcepts: CBL-SL (Ubiquitin-Transferase Gene)\tCutaneous Leishmaniases, Diffuse (Disease due to Trypanosomatidae)\tRNA Proof-Reading (Transcription Process)\th*ng/mL/(mg/kg) (Quantitative Concept)\tCyclins and Cell Cycle Regulation (Molecular Function)", + "output": "CBL-SL (Ubiquitin-Transferase Gene)" + }, + { + "input": "Definition: something described as merriam-Webster: The pressure that is characteristic of the arterial pulse and represents the difference between diastolic and systolic blood pressures of the heart cycle\nConcepts: human puberty (Finding related to maturity of sexuality)\tinfrequent (Time frame)\tMouth Rinse (Mouthwash)\tarterial pressure (Systemic arterial pressure)\tDental Materials, Adhesive, Impression Material/Tray (Biomedical or Dental Material)", + "output": "arterial pressure (Systemic arterial pressure)" + }, + { + "input": "Definition: Pasteurellaceae Infections described as infections with bacteria of the genus ACTINOBACILLUS.\nConcepts: WD1-Years Studying in School/College (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)\tActinobacillus infection, NOS (Pasteurellaceae Infections)\tTertiary Protein Structure (Protein Structure)\tcellular response to organic cyclic compound (cellular response to organic substance)\tFacial dysmorphism (Pathognomic facies)", + "output": "Actinobacillus infection, NOS (Pasteurellaceae Infections)" + }, + { + "input": "Definition: Fusion protein described as a fusion protein encoded by the NUP98/PRRX1 fusion gene. This protein is comprised of the N-terminal nucleoporin GLFG repeat domains of the nuclear pore complex protein Nup98-Nup96 protein fused to the C-terminal DNA-binding homeobox domain of the paired mesoderm homeobox protein 1.\nConcepts: Conjunctival Melanoma cT3 TNM Finding v8 (Conjunctival Melanoma Clinical Primary Tumor TNM Finding v8)\tNUP98-PMX1 Fusion Protein (Fusion protein)\tcaucasian (Racial group)\tprotein localisation to septin ring (protein localization to cell cortex)\tPeptostreptococcus morbillorum (Streptococcus)", + "output": "NUP98-PMX1 Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Unit of Catalytic Activity Concentration described as unit of catalytic activity concentration defined as activity equal to one enzyme unit per one milliliter of system volume.\nConcepts: PET Imagings (Radionuclide imaging - action)\thirschsprung's disease (Other anomalies of intestine)\tHave Trouble Controlling Urine (Clinical or Research Assessment Question)\tEnzyme Unit per Milliliter (Unit of Catalytic Activity Concentration)\tCytoprotection (Physiologic Function)", + "output": "Enzyme Unit per Milliliter (Unit of Catalytic Activity Concentration)" + }, + { + "input": "Definition: Male Reproductive System Finding described as an opening in the prostate gland due to traumatic or pathologic processes.\nConcepts: molecular sieving (Laboratory Procedure)\tAVL01037 (ADNI-AVLT Questionnaire Question)\tDeleterious ATM Serine/Threonine Kinase Gene Mutation (Cell or Molecular Dysfunction)\tProstatic Perforation (Prostatic signs, symptoms and disorders NEC)\tThiopurine methyltransferase (Purine and pyrimidine disorder marker enzyme)", + "output": "Prostatic Perforation (Prostatic signs, symptoms and disorders NEC)" + }, + { + "input": "Definition: Soft tissues of orbit described as a clear, avascular, gelatinous body that occupies the posterior chamber of the eye. It is bounded by the retina except anteriorly where it lies adjacent to the lens and iris.\nConcepts: female pronucleus assembly (Cell Function)\tcorpus vitreum (Vitreous and/or retinal structures)\tvesicle organisation (Cell Function)\tAcetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-yl ester (Cardiovascular Agents)\tMIR222 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "corpus vitreum (Vitreous and/or retinal structures)" + }, + { + "input": "Definition: Parotid Gland Adenocarcinoma described as an adenocarcinoma with serous acinar cell differentiation that arises from the parotid gland. Patients usually present with a slow growing mass in the parotid area.\nConcepts: Trial Visit Start Rule (Intellectual Product)\toccipital eye centers (Body Part, Organ, or Organ Component)\tParotid Gland Acinic Cell Carcinoma (Neoplastic Process)\trndx safety (Health Knowledge & Behavior)\tregulation of systemic arterial blood pressure by atrial natriuretic peptide (Organism Function)", + "output": "Parotid Gland Acinic Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a benign smooth muscle neoplasm arising from the urethra. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.\nConcepts: Musculoskeletal torsion, function (MUSCULOSKELETAL FUNCTIONS: GENERAL TERMS)\tCorynebacterium genitalium (Bacterium)\tRefractory Epithelioid Malignant Peripheral Nerve Sheath Tumor (Epithelioid Malignant Peripheral Nerve Sheath Tumor)\tLeiomyoma of Urethra (Fibroid Tumor)\t(+)-delta-cadinene-8-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)", + "output": "Leiomyoma of Urethra (Fibroid Tumor)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: starch + H2O = alpha-D-glucose.\nConcepts: Acquired hemophagocytic lymphohistiocytosis associated with malignant disease (Lymphohistiocytosis, Hemophagocytic)\tProduct Name Code Modified Text (Name Code Modified Text)\t4q31-q32 (Chromosome band)\tstarch alpha-glucosidase activity (Molecular Function)\toncolytic Newcastle disease virus (Virus)", + "output": "starch alpha-glucosidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as providing biotin based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis.\nConcepts: adenine phosphoribosyltransferase (Phosphoribosyltransferase)\tRP11-59C5.2 (CTBP2 gene)\tBiotin supplement therapy (Health Care Activity)\tgpNMB Positive (Positive Laboratory Test Result)\tNIK/NF-kappaB signal transduction (intracellular signal transduction)", + "output": "Biotin supplement therapy (Health Care Activity)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an alpha-1-glycoproteins immunological test system is a device that consists of the reagents used to measure by immunochemical techniques alpha-1-glycoproteins (a group of plasma proteins found in the alpha-1 group when subjected to electrophoresis) in serum and other body fluids. Measurement of specific alpha-1-glycoproteins may aid in the diagnosis of collagen (connective tissue) disorders, tuberculosis, infections, extensive malignancy, and diabetes.\nConcepts: highly active retroviral therapy (Therapeutic or Preventive Procedure)\tComparative Carcinogenesis (Biomedical Occupation or Discipline)\tALPHA-1-T-GLYCOPROTEIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tInfection, Morbillivirus (Disease or Syndrome)\tVentricular Lead (Medical Device)", + "output": "ALPHA-1-T-GLYCOPROTEIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Enteral feeding management described as change in provision of enteral nutrition formula delivered per time element (e.g., mL/minutes)\nConcepts: Response Group 3 (Clinical or Research Assessment Answer)\tMy thinking was slow (Intellectual Product)\ttransport across blood/cerebrospinal fluid barrier (vascular transport)\tManagement of delivery rate of enteral nutrition (Therapeutic or Preventive Procedure)\tcell-cell signalling involved in mammary gland development (Intercellular Communication Process)", + "output": "Management of delivery rate of enteral nutrition (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Abnormal adipose tissue morphology described as an increase in adipose tissue mass by hyperplastic growth (increase in the number of adipocytes) or by hypertrophic growth (increase in the size of adipocytes occurring primarily by lipid accumulation within the cell).\nConcepts: National Childhood Cancer Foundation (Health Care Related Organization)\tChemical Probe (Miscellaneous Molecular Biology Terms)\tIncreased adipose tissue (General signs and symptoms NEC)\tFeel Too Nauseated to Eat (Intellectual Product)\tregulation of attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation (regulation of attachment of spindle microtubules to kinetochore)", + "output": "Increased adipose tissue (General signs and symptoms NEC)" + }, + { + "input": "Definition: Microbial Sensitivity Tests described as method of measuring the bactericidal activity contained in a patient's serum as a result of antimicrobial therapy. It is used to monitor the therapy in BACTERIAL ENDOCARDITIS; OSTEOMYELITIS and other serious bacterial infections. As commonly performed, the test is a variation of the broth dilution test. This test needs to be distinguished from testing of the naturally occurring BLOOD BACTERICIDAL ACTIVITY.\nConcepts: Serum bactericidal titer (Antimicrobial susceptibility test)\tMaturing Erythroid Cells/Total Cells (Blood Cell Count Ratio Measurement)\tKRC (Turkic language)\tFiltration, Stationary Filter (filtration)\tBABOON (Mammal)", + "output": "Serum bactericidal titer (Antimicrobial susceptibility test)" + }, + { + "input": "Definition: regulation of growth of unicellular organism as a thread of attached cells described as any process that activates or increases the frequency, rate or extent of the process in which cells remain attached after division and form thread-like filaments that may penetrate into a solid growth medium.\nConcepts: Solution for Spray Dosage Form (Biomedical or Dental Material)\tA tubule (Peripheral doublet microtubule of axoneme of cilium)\tD1/3-MAGE-3-His fusion protein (Pharmacologic Substance)\tpositive regulation of growth of unicellular organism as a thread of attached cells (positive regulation of filamentous growth of a population of unicellular organisms)\tdimethylsilanediol metabolism (small molecule metabolic process)", + "output": "positive regulation of growth of unicellular organism as a thread of attached cells (positive regulation of filamentous growth of a population of unicellular organisms)" + }, + { + "input": "Definition: Blood Cell Count Ratio Measurement described as a relative measurement (ratio or percentage) of the metarubricytes to leukocytes in a biological sample. The measurement may be expressed as either a ratio or a percentage.\nConcepts: untreated primitive neuroectodermal tumor, supratentorial, pediatric (Untreated Central Nervous System Neoplasm)\tMETARBLE (Laboratory Procedure)\tdelphinidin 7-O-(6-O-(4-O-(glucosyl)-oxybenzoyl)-glucoside) acyltransferase (acyl-glucose dependent activity (Molecular Function)\thuman spasmolytic protein SML1 (Amino Acid, Peptide, or Protein)\tWnt protein secretion (Cell Function)", + "output": "METARBLE (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Breast Version 4 (FACT-B Version 4) Emotional Well-Being: I feel sad.\nConcepts: FAC005-I Feel Sad (FACT-B Version 4 Questionnaire Question)\tFAMS01-I Feel Tired (Intellectual Product)\tHeels, Cast (Cast Material/Accessories)\tPeriosteal route (Drug Administration Routes)\tInhibitor of Growth Family, Member 1 wt Allele (Gene or Genome)", + "output": "FAC005-I Feel Sad (FACT-B Version 4 Questionnaire Question)" + }, + { + "input": "Definition: something described as caps that fit snugly over the patient's head to cool the scalp to reduce blood flow, typically for the purpose of reducing hair loss (alopecia) related to chemotherapy. These caps are typically cooled to approximately -20 degrees Fahrenheit using dry ice or a freezer before use. Hypothermia caps may come with ear straps that help to keep the cap securely in place.\nConcepts: FORAVIRUMAB (Immunologic Factor)\tyellow sclera (Abnormal conjunctiva morphology)\tLINC00001 (Genes, Regulator)\tabscess of axilla (Non-Neoplastic Axillary Disorder)\tHypothermia Caps (Patient Caps)", + "output": "Hypothermia Caps (Patient Caps)" + }, + { + "input": "Definition: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor described as catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+.\nConcepts: CoA-glutathione reductase activity (Molecular Function)\tMeningitis due to E. coli (Bacterial meningitis due to Gram-negative bacteria)\tLateral Thyrohyoid Ligament (Structure of thyrohyoid ligament)\tUteroplacental Vessel Fibrinoid Necrosis with or without Atherosis (Placental finding)\tVaginal Cancer FIGO Stage III (Finding)", + "output": "CoA-glutathione reductase activity (Molecular Function)" + }, + { + "input": "Definition: Research Activity described as research that involves the application of the natural sciences, especially biology and physiology, to medicine.\nConcepts: Oil, Ethiodized (Iodized Oil)\tapM 1 Protein (peptide hormone)\tNMH (Measurement of substance)\tResearch, Biomedical (Health Services Research)\tArchistriatum (Basal ganglion of telencephalon)", + "output": "Research, Biomedical (Health Services Research)" + }, + { + "input": "Definition: FGFR2 Protein Variant described as a change in the amino acid residue at position 549 in the fibroblast growth factor receptor 2 protein where asparagine has been replaced by histidine.\nConcepts: FGFR2 NP 000132.3:p.Asn549His (Cell or Molecular Dysfunction)\tmethyl fluoride metabolism (halogenated hydrocarbon metabolic process)\tNeurophysiology / Electrophysiology (Science of neurophysiology)\tBMS - Bare metal stent (Metal stent)\tediting (Instruction Imperative)", + "output": "FGFR2 NP 000132.3:p.Asn549His (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Infant Acute Lymphoblastic Leukemia described as a type of acute lymphoblastic leukemia that is seen more frequently in infants younger than six months of age, as compared to those between six months of age and one year; it is characterized by very high white blood cell counts and increased incidence of central nervous system involvement.\nConcepts: HIST1H2BA (Amino Acid, Peptide, or Protein)\tInfant ALL with MLL Rearrangement (Infant Acute Lymphoblastic Leukemia)\tAbnormal DLCO (Finding)\tdietitian (Professional or Occupational Group)\tPAG (Austronesian Language)", + "output": "Infant ALL with MLL Rearrangement (Infant Acute Lymphoblastic Leukemia)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a bispecific antibody against human CD3, a T-cell surface antigen, and human guanylate cyclase 2C (GUCY2C; GCC; guanylyl cyclase C; heat-stable enterotoxin receptor; hSTAR), with potential antineoplastic activity. Upon administration, anti-CD3/anti-GUCY2C bispecific antibody PF-07062119 targets and binds to both CD3 on T-cells and GUCY2C expressed on certain tumor cells. This results in the cross-linking of T-cells and tumor cells, and induces a cytotoxic T-lymphocyte (CTL) response against GUCY2C-expressing tumor cells. GUCY2C, a transmembrane receptor expressed on intestinal epithelial cells, is overexpressed on certain tumors of the gastrointestinal (GI) tract.\nConcepts: Maps as Topics (Intellectual Product)\tReview of Reported Cases (Intellectual Product)\tbromodomain containing 4 (Gene or Genome)\tPF 07062119 (Antineoplastic Antibody)\tHepatocellular Carcinoma pT1b TNM Finding v8 (Finding)", + "output": "PF 07062119 (Antineoplastic Antibody)" + }, + { + "input": "Definition: something described as the organelle membrane fusion process in which the membrane of a multivesicular body fuses with a lysosome to create a hybrid organelle.\nConcepts: MSIR tablets (Proprietary agent AND/OR biological substance)\tProcedure Kit/Trays, Cardioplegia Solution Administration (Procedure Kit/Trays)\tmechanoreceptor differentiation involved in mechanosensory epithelium regeneration (mechanoreceptor differentiation)\tfusion of multivesicular body to lysosome (Cell Function)\tRisk Factor History Negative (Finding)", + "output": "fusion of multivesicular body to lysosome (Cell Function)" + }, + { + "input": "Definition: Disorder of choroid of eye described as the presence of multiple hemangiomas in the choroid. These are generally reddish or orange or can have increased pigmentation maiking them difficult to distinguish from choroidal melanomas.\nConcepts: Drugs, Substandard (Pharmaceutical Preparations)\tADL03-Pastime: Bingo (Intellectual Product)\tRHO KINASE (Serine/Threonine Protein Kinase Gene)\tGrade 4 Mitral Valve Disease, CTCAE (Finding)\tBenign Choroid Hemangioma (Abnormal morphology of the choroidal vasculature)", + "output": "Benign Choroid Hemangioma (Abnormal morphology of the choroidal vasculature)" + }, + { + "input": "Definition: antagonists & inhibitors described as any substance or agent which suppresses or prevents the development of dental cavities or caries.\nConcepts: dental caries inhibitor (Pharmacologic Substance)\tStage IB Vulvar Cancer (Stage I Vulvar Cancer AJCC v8)\tBiopsy - action (Diagnostic tests)\tAdditional Surgery for New Tumor Event Not Evaluated (Finding)\tresponse to phylloquinone (Cell Function)", + "output": "dental caries inhibitor (Pharmacologic Substance)" + }, + { + "input": "Definition: Acoustics described as a type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.\nConcepts: T25FW Functional Test Question (Clinical or Research Assessment Question)\tUnresectable Neuroendocrine Neoplasm (Neoplastic Process)\tVelvet grass (Plant)\tRadiations, Sonic (Physical Phenomenon or Property)\tProtein HSF-27 (Amino Acid, Peptide, or Protein)", + "output": "Radiations, Sonic (Physical Phenomenon or Property)" + }, + { + "input": "Definition: Molecular Function described as combining with transforming growth factor beta to initiate a change in cell activity; facilitates ligand binding to type I and type II TGF-beta receptors.\nConcepts: Capillary (Second left internal vertebral venous plexus)\ttype III TGFbeta receptor activity (transforming growth factor beta receptor activity)\tOne Minute After Birth (Time)\tForced-Air Blankets (Blanket)\tmicroRNA 34a (Gene or Genome)", + "output": "type III TGFbeta receptor activity (transforming growth factor beta receptor activity)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a cytogenetic abnormality that refers to the loss of all or part of the long arm of chromosome 9 (9q). It is associated with the development of acute myeloid leukemia and various types of carcinomas.\nConcepts: Clamps, Surgical, Vascular, Vena Cava, Indwelling Cannula (Medical Device)\tLoss of Chromosome 9q (Chromosomal Loss)\tcompound; presentation (MATERNAL AND FETAL CONDITIONS AFFECTING LABOR AND DELIVERY)\tBiologicSpecimen (Body Substance)\tControllers, Air/Nitrogen Pressure (Controllers)", + "output": "Loss of Chromosome 9q (Chromosomal Loss)" + }, + { + "input": "Definition: something described as a rough-coated, medium-sized dog. It has a large, long head, square muzzle, and soft, thick, bushy eyebrows, beard and mustache. It has a straight, hard, wiry outer coat which is lined with a fine but thick downy undercoat. The coat comes in silver or steel-grey with chestnut or roam markings, or in solid chestnut. The average height range is 20-24 inches and the average weight range is 50-60 pounds.\nConcepts: Wirehaired Pointing Griffon (Canis familiaris)\tNon-Clinical Postpairing Trial Phase (Nonclinical Trial Phase)\t7q35-q36 (Chromosome band)\tMean Corpuscular Volume Reticulocytes (Hematologic Tests)\tMetabolite Ratio AUC Last Nonzero Conc (Area Under the Curve From Dosing to Last Concentration)", + "output": "Wirehaired Pointing Griffon (Canis familiaris)" + }, + { + "input": "Definition: Disease or Syndrome described as a renal functional disorder characterized by proteinuria, edema, hyperlipidemia and hypoalbuminemia. It results from damage to the renal vascular filtration apparatus. It is further characterized by a chronic inflammatory reaction in the glomerular capillaries. Sequelae may include hypertension, atherosclerosis, infection, hypercoagulablity and renal failure.\nConcepts: FAM38A protein, human (Amino Acid, Peptide, or Protein)\tAlanine racemase (Amino Acid Isomerases)\tT1E28z CAR-expressing Autologous CD4-positive T Lymphocytes (Chimeric Antigen Receptor T-cells)\tPHQ-15 - Dizziness (PHQ-15 Questionnaire Question)\tNephrotic syndrome with lesion of persistent glomerulonephritis (Disease or Syndrome)", + "output": "Nephrotic syndrome with lesion of persistent glomerulonephritis (Disease or Syndrome)" + }, + { + "input": "Definition: Biologically Active Substance described as the pri-miRNA is a primary transcript derived from a gene whose sole products are miRNA(s). A unique pathway involving the nuclear microprocessor complex participates in the cleavage of such transcripts, which can be substantially longer than the 65-110 nt pre-miRNA.\nConcepts: Deficiency of anterior part of lower alveolar ridge (Disorder of mandible)\tINCMGA0012 (Anti-PD1 Monoclonal Antibody)\tP1-CDC21 Protein (Minichromosome Maintenance Proteins)\tparathyroid mixed cell type adenoma (Benign Parathyroid Gland Adenoma)\tmiRNA, Primary (RNA, Untranslated)", + "output": "miRNA, Primary (RNA, Untranslated)" + }, + { + "input": "Definition: Enzyme described as a 17-KDa cytoplasmic PEPTIDYLPROLYL ISOMERASE involved in immunoregulation. It is a member of the cyclophilin family of proteins that binds to CYCLOSPORINE.\nConcepts: 1: 158332873-158324608 (Chromosome 1 Physical Location)\torganochlorine insecticide (Insecticides)\tSEB (Immunologic Factor)\tCyclophilin A (Enzyme)\tRIP3 (Ligand Binding Protein Gene)", + "output": "Cyclophilin A (Enzyme)" + }, + { + "input": "Definition: something described as chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.\nConcepts: female contraceptives (Contraceptive Agents)\tSyringes, Plunger, Prefilled, Medication, Blunt Cannula (Medical Device)\tTribbles Homolog 2 (Amino Acid, Peptide, or Protein)\tHPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pT3 TNM Finding v8 (HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Primary Tumor TNM Finding v8)\tNanophthalmos, retinitis pigmentosa, foveoschisis, optic disc drusen syndrome (Optic Disk Drusen)", + "output": "female contraceptives (Contraceptive Agents)" + }, + { + "input": "Definition: something described as a chromosome band present on 12q\nConcepts: GLEPP1 (Receptor-Type Protein Tyrosine Phosphatase Gene)\tLyngbya (Agardh 1827) ex Gomont 1892 (Cyanobacteria)\t12q11-q13 (Cell Component)\tstr (Derived Unit of International System of Units)\tProfound mental retardation with IQ less than 20 (Korean Standard Classification of Disease Version 5)", + "output": "12q11-q13 (Cell Component)" + }, + { + "input": "Definition: Finding of sternum structure described as decreased inferosuperior length of the sternum.\nConcepts: Short sternum (Form of sternum)\tup-regulation of female receptivity, post-mating (Organism Function)\tRelaxation, Vascular Endothelium-Dependent (Organ or Tissue Function)\tIVD Test Reagent/Kits, Hematology, Coagulation Factor VII, Activated (Medical Device)\tOxdA (acid-D-amino acid ligase activity)", + "output": "Short sternum (Form of sternum)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development.\nConcepts: Submission Unit (Document type)\tnegative regulation of ovarian development (negative regulation of gonad development)\tCarbohydrate Processing Inhibitor (Antineoplastic Agents)\tStriatin, Calmodulin-Binding Protein (Biologically Active Substance)\tDay centre care (Thesaurus of Psychological Index Terms)", + "output": "negative regulation of ovarian development (negative regulation of gonad development)" + }, + { + "input": "Definition: acetaminophen / caffeine described as a combination preparation containing pyrilamine, caffeine and acetaminophen. Pyrilamine is an ethylenediamine antihistamine that blocks H1 receptors and exerts local anesthetic, sedative and mild analgesic activities. Caffeine is a central nervous system stimulant. Acetaminophen possesses analgesic and antipyretic effects. This preparation is used for the relief of premenstrual and menstrual symptoms.\nConcepts: WS4A (Inherited autonomic nervous system disorder)\tmL/sec/kg (Quantitative Concept)\tRisk for adverse reaction to iodinated contrast media (Defensive processes)\tToxicity Grade Code (Intellectual Product)\tacetaminophen + caffeine + pyrilamine (acetaminophen / caffeine)", + "output": "acetaminophen + caffeine + pyrilamine (acetaminophen / caffeine)" + }, + { + "input": "Definition: something described as techniques that involve the in vitro synthesis of multiple copies of nucleic acids from an original template.\nConcepts: Binocular vision observable (Mental Process)\tBenign Adipose Tissue Neoplasm (Lipomatous neoplasm)\tRicker Syndrome (Disease or Syndrome)\tnucleic acid amplification technique (Molecular Biology Research Technique)\tPendant (Tag Dosage Form)", + "output": "nucleic acid amplification technique (Molecular Biology Research Technique)" + }, + { + "input": "Definition: Multiple malformation syndrome with limb defect as major feature described as acrorenal syndrome comprises a wide spectrum of congenital malformation disorders with characteristics of the co-occurrence of distal limb anomalies (usually bilateral cleft feet and/or hands) and renal defects (for example unilateral or bilateral agenesis), that can be associated with a variety of other anomalies such as those of genitourinary tract, abdominal well defects, intestinal atresia and lung malformations. Familial cases have been reported in which an autosomal recessive inheritance was suspected.\nConcepts: electronic pacemaker (Heart, Artificial)\tNorovirus GII RNA (Laboratory Procedure)\tACRORENAL SYNDROME (Multiple malformation syndrome with limb defect as major feature)\tAngina of effort (Elderly)\tClinicalTrials.gov (Web Site)", + "output": "ACRORENAL SYNDROME (Multiple malformation syndrome with limb defect as major feature)" + }, + { + "input": "Definition: Biologic Function described as the process whose specific outcome is the progression of a trachea over time, from its formation to the mature structure. The trachea is the portion of the airway that attaches to the bronchi as it branches.\nConcepts: trachea development (Organogenesis)\tCyclophosphamide/Mitoxantrone/Prednisone/Vincristine (Therapeutic or Preventive Procedure)\tBRAF(V600E) Kinase Inhibitor RO5212054 (BRAF inhibitor)\tVaginal Glandular Neoplasm (Neoplastic Process)\tshock; allergy (BODY AS A WHOLE - GENERAL DISORDERS)", + "output": "trachea development (Organogenesis)" + }, + { + "input": "Definition: something described as integrated program having an objective of reducing risk, incidence, and mortality from cancer and to enhancing the quality of life for cancer survivors. Realized through an orderly sequence of measures from genetic, epidemiologic, behavioral, social, applied, and surveillance cancer research to the development and implementation of effective interventions, and monitor and analysis of cancer trends in all segments of the population.\nConcepts: Importance Score 8 (10-Point Importance Scale)\tCancer Control (Cancer Intervention)\t4H-1-Benzopyran-2-carboxylic acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, disodium salt) (Miscellaneous Drugs)\tBlood Specimen Collections (removal technique)\tDose-dispenser cartridge (Manufactured Object)", + "output": "Cancer Control (Cancer Intervention)" + }, + { + "input": "Definition: Comfort alteration described as aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.\nConcepts: pain; chronic (Pain, not elsewhere classified)\tAdministration, Self (Pharmacotherapy)\ttheta replication (Genetic Function)\tPLAGL2 wt Allele (Gene or Genome)\tRespiratory Arrest (Abnormal breathing)", + "output": "pain; chronic (Pain, not elsewhere classified)" + }, + { + "input": "Definition: something described as a type of computed tomography (CT) whereby images are taken during the portal venous phase post contrast medium injection. The portal venous phase is defined as the time period in which the contrast medium has passed the heart and the arterial blood vessels and has entered the hepatic portal vein. This type of CT does only apply to liver imaging.\nConcepts: Adult Mesenchymal Chondrosarcoma (Mesenchymal Chondrosarcoma)\tFather Child Relationship (Parent-Child Relationship)\tGrade 2 Mediastinal hemorrhage (Finding)\tPortal Venous Phase Spiral CT (Phased Spiral CT)\tAuditory Feedback (Sensory Feedback)", + "output": "Portal Venous Phase Spiral CT (Phased Spiral CT)" + }, + { + "input": "Definition: Organic Chemical described as derivatives of ethylamine (the structural formula CH3CH2NH2).\nConcepts: Isomerases, Aldose-Ketose (Amino Acid, Peptide, or Protein)\tCatheters, Biliary, Drainage, Percutaneous (Medical Device)\tEthylamines (Amines)\tAbnormality of the distal ulnar epiphysis (Anatomical Abnormality)\tFirst Diagonal Branch Artery (Body Part, Organ, or Organ Component)", + "output": "Ethylamines (Amines)" + }, + { + "input": "Definition: Neonatal Rash, Adverse Event described as localized rash.\nConcepts: Left upper third facial depth line (Body Location or Region)\tGrade 1 Neonatal Rash, AE (Finding)\tProtein Enabled Homolog Isoform Expression Assay (Immunologic Tests)\tProtein, Catenin (Cytoskeletal Proteins)\tmorphine catabolic process (morphine metabolic process)", + "output": "Grade 1 Neonatal Rash, AE (Finding)" + }, + { + "input": "Definition: skin biopsy technique described as removal of a small disk-shaped sample of tissue using a sharp, hollow device. The tissue is then examined under a microscope.\nConcepts: FIGO Stage I Carcinoma of the Cervix (Neoplastic Process)\tPunch biopsy of skin NOS (Punch biopsy of skin)\tBee Smoke Paper Dosage Form (Veterinary Dosage Form)\tpediatric nursing (Biomedical Occupation or Discipline)\tregulation of calcium ion-dependent exocytosis of neurotransmitter (Cell Function)", + "output": "Punch biopsy of skin NOS (Punch biopsy of skin)" + }, + { + "input": "Definition: GDS Questionnaire Question described as geriatric Depression Scale - Do you feel pretty worthless the way you are now?\nConcepts: Perihilar Bile Duct Cancer pM1 TNM Finding v7 (Perihilar Bile Duct Cancer Pathologic Distant Metastasis TNM Finding v7)\torganismal reproductive process (Cell Function)\tBrown acetate of lime (Calcium/bismuth antacids)\tGDS01-Feel Worthless (GDS Questionnaire Question)\tUFM1 hydrolase activity (Molecular Function)", + "output": "GDS01-Feel Worthless (GDS Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as a substance being studied in the treatment of several types of cancer. It blocks enzymes needed for cell division and may kill cancer cells. It is a type of histone deacetylase (HDAC) inhibitor.\nConcepts: FLJ23608 (GOLM1 gene)\tpolar notch (frontal lobe)\tMetastatic Thyroid Gland Cancer (Thyroid carcinoma)\tmocetinostat (Histone deacetylase inhibitor)\tAcute necrotizing ulcerative gingivitis (disorder) [Ambiguous] (Soft Tissue Infection)", + "output": "mocetinostat (Histone deacetylase inhibitor)" + }, + { + "input": "Definition: Finding described as problem associated with the inability of the device to turn on related to energy delivered to the device.\nConcepts: ERMAXS (Quantitative Concept)\tInformation Storage (Storage)\tStage II Ampulla of Vater Neuroendocrine Tumor (Neoplastic Process)\tPower-Up, Failure To (Power Problem)\tEPND (Gene or Genome)", + "output": "Power-Up, Failure To (Power Problem)" + }, + { + "input": "Definition: something described as the physiological, developmental and morphological changes that occur in a symbiont zoospore during the process of its encystment. Encystment means to enter a state of essentially suspended animation in which the spore is protected by an outer coating and remains immobile and inactive until favorable conditions for growth occur again. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Missionary (Occupational Groups)\tJoint Effusion, CTCAE 5 (Finding)\tBirth Rate (Quantitative Concept)\tzoospore encystment on host (Organism Function)\tglycero-3-phosphocholine acyltransferase activity (Molecular Function)", + "output": "zoospore encystment on host (Organism Function)" + }, + { + "input": "Definition: something described as the volume enclosed by the membrane of an eary phagosome.\nConcepts: early phagocytic vesicle lumen (phagocytic vesicle lumen)\tphytoalexin metabolism (Cell Function)\tThought of Telling Spouse or Partner that I May be Unable to Have Children Makes me Uncomfortable (Intellectual Product)\tPerformedImagingStudy.imagingAccessionIdentifier (Imaging Accession Identifier)\tLeft Circumflex Artery Ostium (Body Part, Organ, or Organ Component)", + "output": "early phagocytic vesicle lumen (phagocytic vesicle lumen)" + }, + { + "input": "Definition: Neuropsychological Tests described as a neuropsychological test of visual attention and task switching that requires a subject to connect a sequence of 25 consecutive targets. It provides an easy to administer and reliable assessment of attention, sequencing, cognition, visual search, and motor function.\nConcepts: Distal Esophagus Squamous Cell Carcinoma (Neoplastic Process)\tTrail Making Test (Intellectual Product)\tImmediate (Pause Description)\tmeiotic spindle assembly (spindle assembly)\tDelousing Kits (Medical Device)", + "output": "Trail Making Test (Intellectual Product)" + }, + { + "input": "Definition: Biliary Tract Diseases described as jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.\nConcepts: Ulocuplumab (Amino Acid, Peptide, or Protein)\tstage I pleural mesothelioma (Neoplastic Process)\tTargeting Signals, Peroxisome (Amino Acid Sequence)\tup-regulation of cutin biosynthetic process (Molecular Function)\tcholestatic icterus (Obstruction of biliary tree)", + "output": "cholestatic icterus (Obstruction of biliary tree)" + }, + { + "input": "Definition: Intellectual Product described as current Opioid Misuse Measure test name.\nConcepts: Governing Board (Organization and Administration)\tCDISC Questionnaire COMM Test Name Terminology (CDISC Questionnaire Terminology)\tIntravascular Angioleiomyoma (Neoplastic Process)\tBeta-2 Globulin Measurement (Laboratory Procedure)\tDriving, Automobile (Community living activity)", + "output": "CDISC Questionnaire COMM Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: phosphotransferase activity, carboxyl group as acceptor described as catalysis of the reaction: ATP + butanoate = ADP + butanoyl phosphate + H(+).\nConcepts: ATP:butanoate 1-phosphotransferase activity (Molecular Function)\tBortezomib product (Other antineoplastic agents in ATC)\tCDKI R547 (Antineoplastic Enzyme Inhibitor)\tRetractors (Surgical Instruments)\tCT053 CAR-BCMA T (therapeutic autologous lymphocytes)", + "output": "ATP:butanoate 1-phosphotransferase activity (Molecular Function)" + }, + { + "input": "Definition: regulation of cardiac chamber morphogenesis described as any process that modulates the frequency, rate or extent of cardiac chamber formation.\nConcepts: regulation of cardiac chamber formation (Organ or Tissue Function)\tInterstitial Route of Drug Administration (Drug Administration Routes)\tHeparin Affin Regulatory Peptide (Amino Acid, Peptide, or Protein)\tRespiratory System Findings Completion Status (Qualitative Concept)\tHER2/Neu Positive by Immunohistochemistry 91-100 Percent (HER2/Neu Positive by Immunohistochemistry)", + "output": "regulation of cardiac chamber formation (Organ or Tissue Function)" + }, + { + "input": "Definition: Study Personnel described as a person engaged in research within a study site country.\nConcepts: gastrointestinal pharmacology (Pharmacology)\tFAMS0110 (Intellectual Product)\tStudyCountryPersonnel (Study Personnel)\tHuman herpesvirus 8 (Human herpes simplex virus)\tMyeloablative Chemotherapy (Bone Marrow Ablation)", + "output": "StudyCountryPersonnel (Study Personnel)" + }, + { + "input": "Definition: Centrosome described as self-replicating, short, fibrous, rod-shaped organelles. Each centriole is a short cylinder containing nine pairs of peripheral microtubules, arranged so as to form the wall of the cylinder.\nConcepts: Esophageal Adenocarcinoma by AJCC v8 Stage (Neoplastic Process)\tTSQM Version 1.4 - How Bothersome Are Side Effects (TSQM Version 1.4 Questionnaire Question)\tbone marrow development (Histogenic Process)\tDay Times gram Per Milliliter Per Milligram Per Gram Per Day (Measurement Unit Description)\tCentriole (Organelles)", + "output": "Centriole (Organelles)" + }, + { + "input": "Definition: Signaling Protein described as CD63 antigen (238 aa, ~256 kDa) is encoded by the human CD63 gene. This protein is involved in signal transduction and may play a role in growth regulation.\nConcepts: Manufacturing Date Production Identifier (Processed Product Identifier)\tcopper ion import (copper ion transport)\tCD63 antigen, human (Amino Acid, Peptide, or Protein)\tAssociations and organizational systems (Governmental or Regulatory Activity)\tbehavioural defense response (Organism Function)", + "output": "CD63 antigen, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the determination of the amount of metarubricytes present in a sample.\nConcepts: actin fusion focus formation (cellular component assembly)\tGlycitein (Organic Chemical)\tOrthochromic Normoblast (Laboratory Procedure)\tDRRI1-B: Family Told Me When Problem (Intellectual Product)\tacute necrotizing encephalopathy of childhood (Disease or Syndrome)", + "output": "Orthochromic Normoblast (Laboratory Procedure)" + }, + { + "input": "Definition: NCCN-FACT FBLSI-18 Version 2 Questionnaire Question described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Bladder Symptom Index-18 Version 2 (NCCN-FACT FBLSI-18 Version 2) Because of my physical condition, I have trouble meeting the needs of my family.\nConcepts: Hematopoietic Immune Cell (Cell)\tIVD Panels, Human Genetics, Pulmonary Disorder, Fibrosis/Associated Disease (Medical Device)\tPerformedObservationResult (Result)\tplus-end directed microtubule sliding (Cell Function)\tNCCN-FACT FBLSI-18 Version 2 - Trouble Meeting Needs of Family (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)", + "output": "NCCN-FACT FBLSI-18 Version 2 - Trouble Meeting Needs of Family (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: something described as brushes with a handle and several rows of bristles designed for personal care to smooth and detangle hair. The bristles may be soft or stiff and made of synthetic or natural materials. The handle can be made of plastic, metal, or wood. Hairbrushes can be different shapes and sizes.\nConcepts: santali albi/tan xiang (Oriental herbs and natural substances letter S)\tRepair of patent foramen ovale NOS (repair of congenital septal defect)\tdown-regulation of root hair elongation (regulation of root hair elongation)\tAutosomal dominant Charcot-Marie-Tooth disease type 2A2 (Hereditary Motor and Sensory-Neuropathy Type II)\tHairbrushes (Manufactured Object)", + "output": "Hairbrushes (Manufactured Object)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the portion of the middle cerebellar peduncle that forms the most ventral portion of the basal pons in the rodent ( Paxinos-2001 ).\nConcepts: stem of middle cerebellar peduncle (Body Part, Organ, or Organ Component)\tThromboxane Activity Induction (Eicosanoid Activity Induction)\tLight Curing of Dental Resins (Dental Bonding)\t10p+/10q- syndrome (Disease or Syndrome)\tForeign Language Translation (Intellectual Product)", + "output": "stem of middle cerebellar peduncle (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: cinnamic acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids.\nConcepts: Mucoepidermoid Carcinomas (Mucin-producing adenocarcinoma)\tOculomotor nerve disorder (Finding)\tcinnamic acid biosynthetic process involved in flavonoid metabolism (cinnamic acid biosynthetic process)\tcisternal maturation (Cell Function)\tMunchhausen Syndrome (factitious disorder with physical symptoms)", + "output": "cinnamic acid biosynthetic process involved in flavonoid metabolism (cinnamic acid biosynthetic process)" + }, + { + "input": "Definition: Health Care Activity described as using Ayurvedic assessment methods in a simple, subsequent, 10-minute, in-facility meeting to assess the health status of an existing Ayurvedic medicine client to reevaluate and/or develop an Ayurvedic treatment plan.\nConcepts: stanniocalcin 1 protein, human (peptide hormone)\tAlpr\u00e9nolol (Adrenergic beta-Antagonists)\tnfclty sqnt Ayvdcmed ntak 10 (Existing client in-facility with or without ICD diagnosis)\tIVD Test Reagent/Kits, Home Assay, Urine, Bilirubin (Medical Device)\ttartrate transmembrane transporter activity (Molecular Function)", + "output": "nfclty sqnt Ayvdcmed ntak 10 (Existing client in-facility with or without ICD diagnosis)" + }, + { + "input": "Definition: something described as the increase in length of the aristal core. The arista is the terminal segment of the antenna and consists of a central core and a series of lateral extensions.\nConcepts: elongation of arista core (Organ or Tissue Function)\tAdjusted coding mutation rate per megabase (Mutation Rate)\tMONITOR, HEART RATE, FETAL, ULTRASONIC (Medical Device)\tPseudoramibacter alactolyticus (Eubacterium)\tDental disease (Mouth Diseases)", + "output": "elongation of arista core (Organ or Tissue Function)" + }, + { + "input": "Definition: Liquid Dosage Form described as a liquid dose form consisting of active substance(s) in an alcohol.\nConcepts: Spirit (Biomedical or Dental Material)\tdel(7) (Chromosome 7 Abnormality)\tGrade 4 Agitation, CTCAE (Agitation, CTCAE 5.0)\tstrionigral tract (Body Part, Organ, or Organ Component)\tMaternal Fetal Medicine (Discipline of obstetrics)", + "output": "Spirit (Biomedical or Dental Material)" + }, + { + "input": "Definition: Intellectual Product described as a morphologic qualifier indicating that a cancerous lesion is moderately differentiated.\nConcepts: Stations, Photographic (Electromechanical Devices)\tTMP biosynthetic process (pyrimidine ribonucleotide biosynthetic process)\tGRADE 2 (Disease Grade Qualifier)\tefavirenz (Reverse Transcriptase Inhibitors)\tCitrulline measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "GRADE 2 (Disease Grade Qualifier)" + }, + { + "input": "Definition: Functional Concept described as a system intended to indicate the device status was triggered prematurely.\nConcepts: Diet, Food, and Nutrition (Physiological Phenomena)\tHedgehog Protein (Amino Acid, Peptide, or Protein)\tvascular access device placement (Therapeutic procedure)\tPremature Indicator Activation (Functional Concept)\tWBC morphology - hairy cells count (Atypical Lymphocyte Count Measurement)", + "output": "Premature Indicator Activation (Functional Concept)" + }, + { + "input": "Definition: Diagnostic Procedure described as the use of dyes and radioactive substances to identify the first lymph node to which cancer is likely to spread from the primary tumor. Cancer cells may appear first in the sentinel node before spreading to other lymph nodes and other places in the body.\nConcepts: PERINEPHRIC ABSCESS (Abscess)\tSuicide and Depression (Funding Category)\tBarmah Forest virus (Alphavirus)\tlymph mapping node sentinels (Diagnostic Procedure)\tMYROIDES (Non-fermentative Gram-negative bacillus)", + "output": "lymph mapping node sentinels (Diagnostic Procedure)" + }, + { + "input": "Definition: regulation of cellular amide metabolic process described as any process that modulates the frequency, rate or extent of tensidol A biosynthetic process.\nConcepts: FAC00637 (FACT-BL Version 4 Questionnaire Question)\tTPMT-V4 (Gene or Genome)\tmodulation by symbiont of host innate immune response (Organism Function)\tCOLLIMATOR, DERMATOLOGICAL, THERAPEUTIC X-RAY (Medical Device)\tregulation of tensidol A biosynthesis (regulation of cellular amide metabolic process)", + "output": "regulation of tensidol A biosynthesis (regulation of cellular amide metabolic process)" + }, + { + "input": "Definition: Anatomical line of anal canal described as anatomical line of anal canal, each instance of which overlies some intersphinteric groove.\nConcepts: paramedian lobule (Body Part, Organ, or Organ Component)\tHilton white line (Anatomical line of anal canal)\tMyocardium of apex zone of left ventricle (Body Location or Region)\tNon-Neoplastic Intestinal Disorder (Non-Neoplastic Digestive System Disorder)\tQIDSC1-Hypersomnia (Intellectual Product)", + "output": "Hilton white line (Anatomical line of anal canal)" + }, + { + "input": "Definition: Molecular Function described as a cyclic series of interconversions involving chlorophyll a, chlorophyll b and several chlorophyllide intermediates.\nConcepts: Neck Computed Tomography with Contrast (Computed Tomography (CT) of Neck)\tProject Description (Description)\tHow Often Reminded of Breasts When Picking Clothes to Wear (Clinical or Research Assessment Question)\tClinical Trial Protocol Amendment Summary (Intellectual Product)\tchlorophyll cycle (Molecular Function)", + "output": "chlorophyll cycle (Molecular Function)" + }, + { + "input": "Definition: something described as a small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart.\nConcepts: RADIOIMMUNOASSAY, THYROXINE-BINDING GLOBULIN (Indicator, Reagent, or Diagnostic Aid)\tA-V Node (root)\tcyanidin-3-O-rutinoside 5-O-glucosyltransferase activity (Molecular Function)\tbeta-amyrin synthase activity (Molecular Function)\tpyochelin breakdown (heterocycle catabolic process)", + "output": "A-V Node (root)" + }, + { + "input": "Definition: Finding described as a level of awareness that can be described as consistently not responsive to stimuli.\nConcepts: Ability to Use Hands and Fingers (Clinical or Research Assessment Question)\tConsciousness, Loss of (Finding)\tK63-linked polyubiquitin modification-dependent protein binding (polyubiquitin modification-dependent protein binding)\tCadmium fluorata / cadmium fluoride (Homeopathic remedies letter C)\theterocyst differentiation (Cell Function)", + "output": "Consciousness, Loss of (Finding)" + }, + { + "input": "Definition: something described as a laboratory procedure that involves the examination of tissues or cells for diagnostic or research purposes.\nConcepts: Anatomic pathology procedure (Laboratory Procedure)\tUrinary condom catheter, reusable (Medical Device)\tRight mandibular third molar tooth (Systematized Nomenclature of Dentistry)\tULTRASTRUCT (Cellular aspects of)\tCarfilzomib product (Amino Acid, Peptide, or Protein)", + "output": "Anatomic pathology procedure (Laboratory Procedure)" + }, + { + "input": "Definition: Pharmacologic Substance described as a proprietary, miniature biodegradable polymeric matrix containing small-interfering RNAs for the mutated KRAS oncogene, KRASG12D, (siG12D), with potential antitumor activity. Upon intratumoral injection, siG12D is released locally, thereby preventing translation of KRAS proteins and potentially inhibiting growth of tumor cells overexpressing KRAS. KRAS, a member of the small GTPase superfamily, is mutated in over 90% of human pancreatic ductal adenocarcinomas (PDAC) and is associated with tumor cell proliferation and reduced survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C95772\" active clinical trials using this agent.\nConcepts: WD2S5 (Intellectual Product)\tsiG12D LODER (Pharmacologic Substance)\tD-gluconate degradation (Molecular Function)\tupregulation of transposon integration (Genetic Function)\tFGF (Gene or Genome)", + "output": "siG12D LODER (Pharmacologic Substance)" + }, + { + "input": "Definition: protein localization to mitotic spindle pole body described as any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body.\nConcepts: SF-36 v2.0 Acute - Question 9f (Intellectual Product)\tGrade 1 Vulval infection (Vulval Infection, CTCAE)\tIVD Test Reagent/Kits, Immunoassay, Toxicology, Salicylate (IVD Test Reagent/Kits, Immunoassay, Toxicology)\tPDQUALIF - Important to Maintain Independence (Intellectual Product)\tgamma-tubulin complex localization to mitotic spindle pole body (gamma-tubulin complex localization)", + "output": "gamma-tubulin complex localization to mitotic spindle pole body (gamma-tubulin complex localization)" + }, + { + "input": "Definition: Signaling Pathway Gene described as this gene is involved in GTP binding.\nConcepts: Wernicke's area (Parietal Lobe)\tSubstrate Interaction (Binding)\tGallbladder bile (Gallbladder)\tFoot-and-Mouth Diseases (Skin Diseases, Viral)\tRHPN1 gene (Signaling Pathway Gene)", + "output": "RHPN1 gene (Signaling Pathway Gene)" + }, + { + "input": "Definition: something described as anomaly in the weight-to-height squared ratio, calculated by dividing the individual's weight in kilograms by the square of the individual's height in meters and used as an indicator of obesity and underweight compared to averages. []\nConcepts: SF36 v1.0 Standard - Question 11c (Intellectual Product)\tINVASIVE DIAGNOSTIC EVIDENCE OF HEART FAILURE (Cardiovascular finding)\tCommunity-acquired Pneumonia (Disease or Syndrome)\tAbnormality of body mass index (Finding)\tSquare Window (Research or Clinical Assessment Tool)", + "output": "Abnormality of body mass index (Finding)" + }, + { + "input": "Definition: something described as a congener of pyridine 2-diazohydroxide. Pyrazine diazohydroxide forms DNA adducts via the reactive pyrazine diazonium ion, thereby inhibiting DNA synthesis.\nConcepts: pinene catabolic process (pinene metabolic process)\tbacterial-type flagellum rotor complex location (cellular anatomical entity)\tFocal impaired awareness hemifacial clonic seizure (Focal hemifacial clonic seizure)\tosteoclast differentiation (Cell Function)\tpyrazine-2-diazohydroxide (Pharmacologic Substance)", + "output": "pyrazine-2-diazohydroxide (Pharmacologic Substance)" + }, + { + "input": "Definition: Oral cavity function described as physiologic loss of the primary dentition.\nConcepts: Grade 1 Dermatitis radiation (Finding)\tUnexposed Population (Population Group)\tStreptococcus salivarius Group (Streptococcus)\tExfoliation of teeth, function (Dental Physiological Processes)\tRana lessonae x Rana ridibunda (Amphibian)", + "output": "Exfoliation of teeth, function (Dental Physiological Processes)" + }, + { + "input": "Definition: Finding described as feeling of excessive energy, which may be associated with increased activity.\nConcepts: kinetochore formation (kinetochore organization)\tYAC Clone (Clone)\tincreased energy (Finding of general energy)\tblood vessel endothelial cell fate specification (endothelial cell fate specification)\tBCG intravesical solution (Pharmacologic Substance)", + "output": "increased energy (Finding of general energy)" + }, + { + "input": "Definition: Platelet analyses described as a measurement of the range of platelet sizes in a blood specimen.\nConcepts: Assisting others in communication (Assisting others)\tbrassinosteroid homeostasis (lipid homeostasis)\tLYSOSOMAL TRAFFICKING REGULATOR (Gene or Genome)\tPlatelet distribution width measurement (Hematology procedure)\tDistributions, Sex (Quantitative Concept)", + "output": "Platelet distribution width measurement (Hematology procedure)" + }, + { + "input": "Definition: positive regulation of transcription involved in exit from mitosis described as any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.\nConcepts: X-linked epilepsy with learning disability and behaviour disorder syndrome (Mental or Behavioral Dysfunction)\tOptic nerve disorders (Classification)\tdown regulation of Ca2+-transporting ATPase activity (regulation of ATPase-coupled calcium transmembrane transporter activity)\tNucleus pulvinaris medialis dorsalis (Body Part, Organ, or Organ Component)\tpositive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter (Genetic Function)", + "output": "positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter (Genetic Function)" + }, + { + "input": "Definition: Glycocalyx described as a protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication.\nConcepts: DNA double-strand break attachment to nuclear envelope (Cell Function)\tcapsule (Glycocalyx)\tnephrocyte differentiation (renal filtration cell differentiation)\tCalaspargase Pegol-mknl (Amino Acid, Peptide, or Protein)\tChemoimmunotherapy (Therapeutic or Preventive Procedure)", + "output": "capsule (Glycocalyx)" + }, + { + "input": "Definition: Calicivirus described as a species of non-enveloped and spherical viruses with a capsid with T=3 icosahedral symmetry in the Caliciviridae family and Norovirus genus. The genome is composed of single-stranded, positive-sense RNA. Norwalk viruses are found in humans and causes acute viral gastroenteritis. Norwalk viruses are transmitted via oral ingestion or fecal-oral contamination.\nConcepts: 5-aminolevulinate:pyruvate aminotransferase activity (Molecular Function)\tBuckwheat Hull Garments (Medical Device)\tNORWALK VIRUS (N [Preparations])\tvidarabine anhydrous (V [Preparations])\tAcid, Hydrocyanic (generic drug products begining with the letter H)", + "output": "NORWALK VIRUS (N [Preparations])" + }, + { + "input": "Definition: something described as clinical or physiological indicators that precede the onset of disease.\nConcepts: regulation of ferricrocin biosynthesis (Molecular Function)\tSign, Prodromal (Signs and Symptoms)\tlymphoma, childhood lymphoblastic non-Hodgkin's (stage/cell type, childhood non-Hodgkin lymphoma)\tmesoderm cell fate determination (cell fate determination)\tregulation of actin cortical patch localisation (regulation of cellular localization)", + "output": "Sign, Prodromal (Signs and Symptoms)" + }, + { + "input": "Definition: Sclerosis of thumb phalanx described as sclerosis of one or more of the epiphyses of the thumb, leading to an increased degree of radiopacity (white or ivory appearance) in X-rays.\nConcepts: Perihilar Bile Duct Cancer pT0 TNM Finding v7 (Finding)\tPreceptoring: student (Educational Activity)\tIncreased bone density of end part of the thumb (Sclerosis of thumb phalanx)\tGlutaminuria (Neutral hyperaminoaciduria)\tComprehensive prolonged 180 minute new phone consult homeopathic intake (Phone conversations with or without ICD diagnosis)", + "output": "Increased bone density of end part of the thumb (Sclerosis of thumb phalanx)" + }, + { + "input": "Definition: Structure of bone marrow of vertebral body described as bone marrow in a vertebral bone.\nConcepts: Cartoon (Pictorial Work)\tlung ischemia/hypoxia (Ischemia)\tBONE MARROW, VERTEBRUM (Bone marrow part)\tEndomycetale (Saccharomycetes)\tMedicine, Ayurvedic (Traditional Medicine)", + "output": "BONE MARROW, VERTEBRUM (Bone marrow part)" + }, + { + "input": "Definition: Tumor Cell Derivative Vaccine described as a therapeutic agent produced by isolating tumor cells from an individual and processing these tumor cells into a vaccine formulation in vitro; the vaccine is then administered to the individual from whom the tumor cells were isolated. Typically combined with an adjuvant immunostimulant, an autologous cell vaccine may elicit a cytotoxic T-lymphocytic immune response to cell surface-expressed tumor-associated antigens (TAAs), resulting in tumor cell death. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1980\" active clinical trials using this agent.\nConcepts: Aurora B/C kinase inhibitor GSK1070916A (Antineoplastic Enzyme Inhibitor)\tday*pg/mL/(mg/g/day) (Measurement Unit Description)\tvon Economo's encephalitis (DISEASES OF POSSIBLE VIRAL ORIGIN)\tDenture Base (Dentures and Denture Products)\tATCV (Tumor Cell Derivative Vaccine)", + "output": "ATCV (Tumor Cell Derivative Vaccine)" + }, + { + "input": "Definition: something described as vascular surgical clips designed for the atraumatic compression of veins or arteries during microsurgical procedures, usually to cause total or partial temporary occlusion. These clips are typically small cross-action snap-on instruments. Microsurgical vascular clips are typically used in vascular procedures such as testicular implantation; they are also used in the restoration of the vas deferens after vasectomy (i.e., vasovasostomy).\nConcepts: Clips, Surgical, Vascular, Microsurgery (Clips, Surgical, Vascular)\tAutologous Cultured Acute Myeloid Leukemia-specific Cytotoxic T Lymphocytes (Cell)\tGrade 1 Lactation Disorder, CTCAE (Lactation Disorder, CTCAE)\tBorg Scale Rating of Perceived Exertion Score 18 (Intellectual Product)\tPseudoepiphysis of the 5th metacarpal (Abnormality of the epiphysis of the 5th metacarpal)", + "output": "Clips, Surgical, Vascular, Microsurgery (Clips, Surgical, Vascular)" + }, + { + "input": "Definition: something described as a change in the nucleotide sequence of the SETBP1 gene.\nConcepts: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity (O-acetyltransferase activity)\tSpt-Ada-Gcn5-acetyltransferase complex location (SAGA-type complex)\tSEB Gene Mutation (Gene Mutant)\tEctopic Gene Expressions (Gene Expression Regulation)\tNCCN-FACT-FPSI 17 Version 2 - I Have Bone Pain (Intellectual Product)", + "output": "SEB Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a rare genetic chronic skeletal disorder with characteristics of peripheral osteolysis, interphalangeal joint erosions, subcutaneous fibrocollagenous nodules, facial dysmorphism, and a wide range of associated manifestations. The prevalence and incidence of MONA are not known. Fewer than 50 cases have been reported worldwide. MONA spectrum disorders are caused by mutations in the MMP2 gene (16q13-q21) or MMP14 gene (14q11-q12). Follows an autosomal recessive pattern of inheritance. Many cases are reported in children from consanguineous unions.\nConcepts: alpha-1,4-mannosyltransferase activity (Molecular Function)\tqrs complex (EKG impression)\tOvoid (shape of nodule)\tSolanum melongena L. Extract Cream (Pharmacologic Substance)\tMONA (multicentric osteolysis nodulosis arthropathy) spectrum (Hereditary disorder of musculoskeletal system)", + "output": "MONA (multicentric osteolysis nodulosis arthropathy) spectrum (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: something described as stage IA includes: T1, M0, Risk factors: low risk. T1: Tumor confined to uterus. M0: No distant metastasis.\nConcepts: Stage IA Gestational Trophoblastic Tumor (Stage I Gestational Trophoblastic Tumor AJCC v7)\tFood Science and Technology (Occupation or Discipline)\tProtandrous Organisms (Eukaryote)\tSXL-01 (Nucleic Acid, Nucleoside, or Nucleotide)\tb haemophilia (Korean Standard Classification of Disease Version 5)", + "output": "Stage IA Gestational Trophoblastic Tumor (Stage I Gestational Trophoblastic Tumor AJCC v7)" + }, + { + "input": "Definition: Inhaler described as a container of medication intended to refill an inhaler.\nConcepts: Inhaler, Refill (Inhaler)\tRight inferior phrenic vein (Inferior systemic venous tree)\tElaC Ribonuclease Z 2 wt Allele (ELAC2 gene)\tAMYLASEP (Laboratory Procedure)\tPartial duplication of the phalanx of hand (Duplication of phalanx of hand)", + "output": "Inhaler, Refill (Inhaler)" + }, + { + "input": "Definition: Intellectual Product described as model for End Stage Liver Disease test name.\nConcepts: Mimiviridae (Virus)\tTotal Body Clearance by Fraction of Dose for Dose Interval (Biological Clearance Rate)\tModel for End Stage Liver Disease Clinical Classification Test Name (CDISC Clinical Classification Terminology)\tNon-Target Enhancing Lesion Response (Finding)\thydrogen:acceptor oxidoreductase activity (Molecular Function)", + "output": "Model for End Stage Liver Disease Clinical Classification Test Name (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Platelet analyses described as abnormally low level of platelets in the blood.\nConcepts: Thrombocytopenia (hematology: nonspecific abnormal findings)\tEGFR c.2581C>G (EGFR Exon 21 Mutation)\tIDSC1-Concentration/Decision Making (IDS-C Clinical Classification Question)\tTrial Team Subcategory (Document type)\tUnmasking (Functional Concept)", + "output": "Thrombocytopenia (hematology: nonspecific abnormal findings)" + }, + { + "input": "Definition: Oxidoreductase Gene described as this gene is involved in carbohydrate metabolism.\nConcepts: protein halogenation (Molecular Function)\tnegative regulation of sphingolipid biosynthetic process (negative regulation of lipid biosynthetic process)\tEXACT1-Short Breath Personal Care (Intellectual Product)\tSubnucleus reticulatus (Body Part, Organ, or Organ Component)\tOCT1 COACTIVATOR IN S PHASE, 38-KD COMPONENT (Oxidoreductase Gene)", + "output": "OCT1 COACTIVATOR IN S PHASE, 38-KD COMPONENT (Oxidoreductase Gene)" + }, + { + "input": "Definition: Generic Role described as the function performed by the staff person within the organization.\nConcepts: MP 529 (Antineoplastic Antibody-Drug Conjugate)\tThinking of all the years you have worked, have you ever worked in a place where other people smoked cigarettes indoors (Clinical or Research Assessment Question)\tOrganization Staff Role (Functional Concept)\tSet of nuclei of inferior colliculus (Body Part, Organ, or Organ Component)\tMetarubricyte (Complete Blood Count)", + "output": "Organization Staff Role (Functional Concept)" + }, + { + "input": "Definition: Immunologic Factor described as suspensions of attenuated or killed fungi administered for the prevention or treatment of infectious fungal disease.\nConcepts: ENZYME CONTROLS (Medical Device)\tOxidative Burst (respiratory burst involved in defense response)\tVaccines, Fungal (Pharmacologic Substance)\tAbsent/small innermost pinky toe bone (Abnormality of the proximal phalanx of the 5th toe)\tSecondary Cataracts (Other cataract)", + "output": "Vaccines, Fungal (Pharmacologic Substance)" + }, + { + "input": "Definition: tumor necrosis factor superfamily cytokine production described as the appearance of tumor necrosis factor superfamily member 11 (TNFSF11; RANKL) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\nConcepts: Mannan Binding Protein (Lectin)\ttumor necrosis factor ligand superfamily member 11 production (Molecular Function)\tTF-SIII (Protein or Riboprotein Complex)\tDEATH SUDDEN (Pathologic Function)\t2-Aminopurine-6-thiol Hemihydrate (guanine analog)", + "output": "tumor necrosis factor ligand superfamily member 11 production (Molecular Function)" + }, + { + "input": "Definition: something described as fixed beds designed using a configuration resembling a baby cradle to protect patients. These beds typically incorporate fixed endrails and movable and latchable siderails and/or a fabric framed canopy. Cradle fixed beds restrain patients passively and avoid the risk of patient falls; both adult and child cradle beds are available.\nConcepts: Beds, Fixed, Cradle (Medical Device)\tTDP-4-keto-rhamnose reductase activity (Molecular Function)\tLung Cancer pT2a TNM Finding v7 (Lung Cancer pT2 TNM Finding v7)\tTunneled Pleural Catheter Drainage (Thoracic Surgical Procedures)\tGrade 1 Papulopustular rash (Finding)", + "output": "Beds, Fixed, Cradle (Medical Device)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the science of drugs prepared from natural-sources including preparations from PLANTS, animals, and other organisms as well as MINERALS and other substances included in MATERIA MEDICA. The therapeutic usage of plants is PHYTOTHERAPY.\nConcepts: W-molybdopterin cofactor metabolism (molybdopterin cofactor metabolic process)\tL-threonine transmembrane transporter activity (L-amino acid transmembrane transporter activity)\tmin*pg/mL/(mg/g/day) (Measurement Unit Description)\tPharmacognosies (Botany)\tNon-Neoplastic Peritoneal and Retroperitoneal Disease (Peritoneal and retroperitoneal disorders)", + "output": "Pharmacognosies (Botany)" + }, + { + "input": "Definition: something described as a colorless, flammable, carcinogenic liquid with a highly irritating odor. Chloromethyl methyl ether is used in the synthesis of chloromethylated compounds, as an alkylating agent, and as a solvent in the manufacture of water repellents, ion-exchange resins, and industrial polymers. Exposure to its vapors causes severe irritation of the skin, eyes, mucous membranes, respiratory tract as well as pulmonary edema, pneumonia and lung cancer (mainly small-cell type) in humans. Chloromethyl methyl ether is a known human carcinogen.\nConcepts: Foetal lipoma, NOS (Benign lipomatous tumor)\tTricuspid valve disease (Finding)\tLPS receptor (Clusters of differentiation)\tChloromethoxymethane (Organo-halide Carcinogen)\tFascia, Lumbar (Structure of fascia of trunk)", + "output": "Chloromethoxymethane (Organo-halide Carcinogen)" + }, + { + "input": "Definition: Cell Component described as a small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell.\nConcepts: Social Circumstances (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Russian Edition)\tGenus Cucurbita (Plant)\tmicroneme (intracellular membrane-bounded organelle)\tA Little Important (Intellectual Product)\tUrachal diverticulum (Congenital Abnormality)", + "output": "microneme (intracellular membrane-bounded organelle)" + }, + { + "input": "Definition: Persistent Pulmonary Hypertension of the Newborn, Adverse Event described as technical evidence of increased RV-pressures; no clinical symptoms.\nConcepts: Recurrent Testicular Lymphoma (Recurrent Lymphoma)\tGrade 1 Persistent Pulmonary Hypertension of the Newborn (Finding)\tcisplatin (Pharmacologic Substance)\tOligomeric Flavanols (Pharmacologic Substance)\tGlucose preparation (glucose)", + "output": "Grade 1 Persistent Pulmonary Hypertension of the Newborn (Finding)" + }, + { + "input": "Definition: something described as the completed action of obtaining pictures of the interior or exterior of the body usually for diagnostic reasons. EXAMPLE(S): X-ray, MRI, etc\nConcepts: Concentric hypertrophic cardiomyopathy (Disease or Syndrome)\tGloves, Chemical Resistant, Chemotherapy (Gloves, Chemical Resistant)\tPerformedImaging (Research Activity)\tnuclear pre-replicative complex assembly involved in mitotic cell cycle (mitotic cell cycle process)\tAshiatsu Oriental Bar Therapy(TM) each 15 minutes (Massage)", + "output": "PerformedImaging (Research Activity)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-hydroxy-(deoxy)adenosine-triphosphate + H2O = 2-hydroxy-(deoxy)adenosine phosphate + diphosphate.\nConcepts: LITERATURE (Communications Media)\tNewborn Heart Rate (heart rate)\t2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity (nucleoside-triphosphate diphosphatase activity)\tPhase (Conceptual Entity)\tExhalation Valve Device (Valve Device)", + "output": "2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity (nucleoside-triphosphate diphosphatase activity)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: L-altrarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O.\nConcepts: Sturge-Weber-Krabbe syndrome (Venous malformation)\tL-talarate dehydratase activity (Molecular Function)\tDevice Properties Test Code (Intellectual Product)\tVenlafaxinum (Nitrogen and nitrogen compound)\tcell-cell signaling involved in kidney development (Intercellular Communication Process)", + "output": "L-talarate dehydratase activity (Molecular Function)" + }, + { + "input": "Definition: something described as nanograms per milligram of creatinine.\nConcepts: ug/g{Creatinine} (Miscellaneous Concentration Unit)\torganomercurial transmembrane transporter activity (transmembrane transporter activity)\tC-19 gibberellin 2beta-hydroxylase activity (gibberellin 2-beta-dioxygenase activity)\tGrade 1 Prolapse of Intestinal Stoma, CTCAE (Finding)\tMicro Tubule (Cytoskeletal Filaments)", + "output": "ug/g{Creatinine} (Miscellaneous Concentration Unit)" + }, + { + "input": "Definition: Enzyme described as a proteolytic enzyme that uses a metal ion, usually zinc, to catalyze the hydrolysis of peptide bonds. This protease is inhibited by metal chelating agents.\nConcepts: nucleoside triphosphate breakdown (Molecular Function)\tTNK1 (Amino Acid, Peptide, or Protein)\tmetalloproteases (Enzymes)\tInsurance (Document type)\tMyeloid Neoplasms with Germline DDX41 Mutation (Neoplastic Process)", + "output": "metalloproteases (Enzymes)" + }, + { + "input": "Definition: Abnormal gallbladder morphology described as presence of a pseudoaneurysm in the artery that supplies the gallbladder and cystic duct with blood. A pseudoaneurysm, also known as a false aneurysm, forms when blood leaks through a breach of the arterial wall but is contained by the adventitia or surrounding perivascular soft tissue.\nConcepts: Mucosal Hyperplasia of the Mouse Intestinal Tract (Disease or Syndrome)\tBerardinelli-Seip Lipodystrophy Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Lysosomal Storage Disease, Lipidosis, Berardinelli-Seip Lipodystrophy)\tCystic artery pseudoaneurysm (Abnormal gallbladder morphology)\tIntermittent Urinary Catheters (Urinary catheter)\tTeachers Study, California (Intellectual Product)", + "output": "Cystic artery pseudoaneurysm (Abnormal gallbladder morphology)" + }, + { + "input": "Definition: Pharmacologic Substance described as a therapeutic cancer vaccine composed of a replication-defective, serotype 5 adenovirus (Ad5) with the viral genes early 1 (E1), early 2b (E2b), and early 3 (E3) deleted, and the human transcription factor brachyury encoded, with potential immunostimulating and antineoplastic activities. Upon subcutaneous administration, the adenoviral brachyury vaccine ETBX-051 expresses the brachyury protein. The expressed brachyury may induce a cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells expressing brachyury, thereby resulting in both immune-mediated inhibition of tumor cell proliferation and tumor cell death. Deletion of the E1, E2b and E3 genes from Ad5 prevents anti-adenovirus immune responses. Brachyury, a tumor-associated antigen (TAA) and member of the T-box family of transcription factors, is overexpressed in a variety of tumor types. It plays an important role in cancer progression and metastasis.\nConcepts: EYE DROPS,POWDER SOLVENT FOR SOLUTION (Drug powder and solvent)\tETBX 051 (Recombinant Viral Vaccine)\tcell adhesion involved in heart morphogenesis (Cell Function)\tneuropathy; multiple (Neuropathy)\tKRAS G12C (Cell or Molecular Dysfunction)", + "output": "ETBX 051 (Recombinant Viral Vaccine)" + }, + { + "input": "Definition: Class Ib antiarrhythmic agent described as the hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting the inward sodium current in cardiac cells, thereby reducing the rate of rise of the cardiac action potential (phase 0) and decreases automaticity in the Purkinje fibers. This slows nerve impulses in the heart and stabilizes the heartbeat. Mexiletine's anesthetic activity is due to its ability to block sodium influx in peripheral nerves, thereby reducing the rate and intensity of pain impulses reaching the central nervous system.\nConcepts: GRP57 (PDIA3 gene)\tBrucella suis Huddleson 1929 (Bacterium)\tMexiletine Hydrochloride (Class Ib antiarrhythmic agent)\tchemical kinetics (chemical reaction)\tWarming Units, Plastic Eyeglass Frames, Hot Air (Warming Units, Plastic Eyeglass Frames)", + "output": "Mexiletine Hydrochloride (Class Ib antiarrhythmic agent)" + }, + { + "input": "Definition: Neoplasm by body site described as a chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.\nConcepts: Teres Muscle (Body Part, Organ, or Organ Component)\tTaste and smell disorders (Classification)\tRisk For Loneliness (At risk for psychosocial dysfunction)\tChronic Lymphoblastic Leukemias (Neoplastic Process)\tVFQ25-Self Administered Format - Main Reason You Gave Up Driving (VFQ25-Self Administered Format Questionnaire Question)", + "output": "Chronic Lymphoblastic Leukemias (Neoplastic Process)" + }, + { + "input": "Definition: regulation of peptidyl-serine dephosphorylation described as any process that stops, prevents or reduces the frequency, rate or extent of peptidyl-serine dephosphorylation.\nConcepts: anti-FLT3 monoclonal antibody 4G8-SDIEM (Antineoplastic Antibody)\tdownregulation of peptidyl-serine dephosphorylation (Molecular Function)\tOsteosclerosis (Physical shape)\tAcetaminophen level (SPECIFIC DRUG AND TOXICOLOGY TESTS)\tKnee Lock Knee-Ankle-Foot Gait Orthoses (Medical Device)", + "output": "downregulation of peptidyl-serine dephosphorylation (Molecular Function)" + }, + { + "input": "Definition: tissue/cell culture described as the maintenance or growth of tissues, organ primordia, or the parts or whole of an organ in vitro in such a way as to allow differentiation or preservation of the architecture or function.\nConcepts: Culture Technique, Organ (Laboratory Procedure)\tMPAI133B (MPAI-4 Questionnaire Question)\tDysgerminomas (ovarian neoplasm)\tNeuropsychiatric Inventory Questionnaire Test Name (Intellectual Product)\tNK2 homeobox 8 (Genes, Homeobox)", + "output": "Culture Technique, Organ (Laboratory Procedure)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Hepatobiliary Version 4 - Social/Family Well-Being: I am satisfied with my sex life.\nConcepts: Neutral hyperaminoaciduria (Aminoaciduria)\tDECIDUUM, HEART, AUTONOMIC NERVOUS SYSTEM, NEURAL CREST-DERIVED (Gene or Genome)\tNo information - temporarily unavailable (Missing Value Reason)\tFAC01514 (FACT-HEP Version 4 Questionnaire Question)\tconjugant formation (Cell Function)", + "output": "FAC01514 (FACT-HEP Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Malignant melanoma - category described as an acral lentiginous melanoma affecting mucosal surfaces.\nConcepts: lipase activity (Molecular Function)\tEpisiotomy, NOS (Incision of introitus of vagina)\tflavonol binding (flavonoid binding)\tMucosal-lentiginous melanoma (Malignant melanoma - category)\tC-11 choline (C [Preparations])", + "output": "Mucosal-lentiginous melanoma (Malignant melanoma - category)" + }, + { + "input": "Definition: Rash Maculo-Papular, CTCAE described as macules/papules covering >30% BSA with moderate or severe symptoms; limiting self care ADL\nConcepts: Grade 3 Rash Maculo-Papular, CTCAE (Rash Maculo-Papular, CTCAE)\tbrudzinski's sign (Reflex Motor and Equilibrium Functions)\tETS2 Proto-Oncogene (ETS2 gene)\tJejunum and Ileum Neuroendocrine Tumor Clinical TNM Finding v8 (Jejunum and Ileum Neuroendocrine Tumor TNM Finding v8)\tWD3-Standing for Long Periods (WHODAS 2.0 12-item Version Self-administered Questionnaire Question)", + "output": "Grade 3 Rash Maculo-Papular, CTCAE (Rash Maculo-Papular, CTCAE)" + }, + { + "input": "Definition: something described as catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine.\nConcepts: spermidine:putrescine 4-aminobutyltransferase (Molecular Function)\tbeta-elemene synthase activity (Molecular Function)\tSodium 23 (Elements, Ions and Simple Compounds)\tMinute Times Nanomole per Liter per Meter Squared (Quantitative Concept)\tup-regulation of TNFSF cytokine production (positive regulation of cytokine production)", + "output": "spermidine:putrescine 4-aminobutyltransferase (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as double-strand-break repair protein rad21 homolog (631 aa, ~72 kDa) is encoded by the human RAD21 gene. This protein is involved in DNA repair, cell cycle-dependent chromosomal cohesion and apoptosis.\nConcepts: cellular response to biphenyl (response to biphenyl)\tTATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR 2G (TBP-Associated Factor Gene)\tnegative regulation of T-helper 17 cell differentiation (negative regulation of T-helper 17 type immune response)\tMembrane Localization Domain (Amino Acid Sequence)\tNXP-1 (DNA repair protein)", + "output": "NXP-1 (DNA repair protein)" + }, + { + "input": "Definition: something described as ovarian, fallopian tube, or primary peritoneal carcinoma with tumor involving one or both ovaries or fallopian tubes with pelvic extension below pelvic brim or primary peritoneal cancer.\nConcepts: calpr tstng 4sts ea. 15min. (Health Care Activity)\tFilm Cartridge (Device Component or Accessory)\tPleomorphic Adenoma of the Soft Palate (Neoplastic Process)\tOvarian, Fallopian Tube, and Primary Peritoneal Carcinoma FIGO Stage II (Finding)\tmucin (Glycoproteins)", + "output": "Ovarian, Fallopian Tube, and Primary Peritoneal Carcinoma FIGO Stage II (Finding)" + }, + { + "input": "Definition: Dicarboxylate described as class of ketodicarboxylic acids, or their salts or esters, derived from oxalic acid; oxaloacetate is an intermediate in the citric acid cycle and is converted to aspartate by a transamination reaction.\nConcepts: (11q13,14q32)x2[100] (Laboratory or Test Result)\tMouse Adrenal Gland Pheochromocytoma (Mouse Adrenal Gland Neoplasms)\tKetosuccinates (Organic Chemical)\tGranulocytes (Blood product)\tAbnormal PR interval (Electrocardiogram abnormal)", + "output": "Ketosuccinates (Organic Chemical)" + }, + { + "input": "Definition: Medical Device described as assisted reproduction microtools are pipettes or other devices used in the laboratory to denude, micromanipulate, hold, or transfer human gametes or embryos for assisted hatching, intracytoplasmic sperm injection (ICSI), or other assisted reproduction methods.\nConcepts: Thymidine Kinase 1, Soluble Gene (Gene or Genome)\tMICROTOOLS, ASSISTED REPRODUCTION (Medical Device)\tRadial Immunodiffusion (ObservationMethod - CodeSystem)\tSGRQ02-Describe Your Current Health (Intellectual Product)\tProtein Kinase D3 Gene (Serine/Threonine Protein Kinase Gene)", + "output": "MICROTOOLS, ASSISTED REPRODUCTION (Medical Device)" + }, + { + "input": "Definition: Organization described as the highest federal court in the United States, consisting of nine justices and having jurisdiction over all other courts in the nation.\nConcepts: United States Supreme Court (federal court)\tA-Esterase (Hydrolase)\tHepatocellular damage (Liver diseases)\tregulation of system process (regulation of multicellular organismal process)\tTFDP2 wt Allele (Gene or Genome)", + "output": "United States Supreme Court (federal court)" + }, + { + "input": "Definition: Salmonella described as a gram negative, rod shaped, non-motile serotype of the bacteria genus Salmonella, species Salmonella enterica, subspecies enterica. Salmonella Pullorum, one of two poultry-adapted strains of Salmonella bacteria, causes Pullorum disease almost exclusively in young chickens.\nConcepts: FAC08408 (FACIT-Dyspnea 10 Item Short Form Questionnaire Question)\tchronic myelomonocytic leukemia (Monocytic leukemia)\tmicrocornea with glaucoma and absent frontal sinus syndrome (Hydrophthalmos)\tplasma kallikrein-kinin cascade (Pathologic Function)\tSalmonella Pullorum (Salmonella group D1 phase 1 y-z)", + "output": "Salmonella Pullorum (Salmonella group D1 phase 1 y-z)" + }, + { + "input": "Definition: INTERNATIONAL CLASSIFICATION OF NEOPLASMS described as a benign or malignant neoplasm arising from the lymphatic vessels.\nConcepts: TTGIGGAB (Tissue Transglutaminase Antibody Measurement)\tbasal nucleus of the amygdala (Body Part, Organ, or Organ Component)\tLymphatic vessel tumour (Vascular Neoplasms)\tRisk Control: Lipid Disorder (Risk control behavior)\tparalimbic region (Body Location or Region)", + "output": "Lymphatic vessel tumour (Vascular Neoplasms)" + }, + { + "input": "Definition: Other osteopathies described as death of bone tissue due to traumatic or nontraumatic causes.\nConcepts: paired mesoderm homeo box 1 (Gene or Genome)\tLIGHT SOURCE, PHOTOGRAPHIC, FIBEROPTIC (Medical Device)\turinary bladder epithelium (Body Part, Organ, or Organ Component)\tOSTEONECROSIS (cancer-related problem/condition)\tRelaxin (Peptide hormones and their metabolites and precursors)", + "output": "OSTEONECROSIS (cancer-related problem/condition)" + }, + { + "input": "Definition: organic substance catabolic process described as the metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.\nConcepts: Grade 3 Anorectal Infection, CTCAE (Anorectal Infection, CTCAE)\tFunction, Cognitive (nervous system process)\tNiece (Niece/nephew)\tBroad radial diaphysis (Abnormality of radial diaphysis)\tlipolysis (Organism Function)", + "output": "lipolysis (Organism Function)" + }, + { + "input": "Definition: Intellectual Product described as version 1.0 of the CDISC Ebola therapeutic area user guide.\nConcepts: Triethylene Thiophosphoramide (Alkylating Drug [EPC])\tEbola Therapeutic Area User Guide v1.0 (Intellectual Product)\tScalpel (knife)\tThoracic duct tree (Body Part, Organ, or Organ Component)\tEIF4C (Translation Process Gene)", + "output": "Ebola Therapeutic Area User Guide v1.0 (Intellectual Product)" + }, + { + "input": "Definition: FACT-BMT Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 (FACT-BMT Version 4) I have frequent colds/infections.\nConcepts: Physicians; Physician/Osteopath; Blood Banking & Transfusion Medicine (Professional or Occupational Group)\tsuppression by virus of host toll-like receptor signaling pathway (negative regulation of toll-like receptor signaling pathway)\tCongenital myopathy with myasthenic-like onset (Hereditary disorder of musculoskeletal system)\tStage IVB Laryngeal Cancer AJCC v7 (Neoplastic Process)\tFAC06142 (Intellectual Product)", + "output": "FAC06142 (Intellectual Product)" + }, + { + "input": "Definition: Sequence Number described as an identifier that describes the relative position of substance use data within a series.\nConcepts: Substance Use Sequence Number (Sequence Number)\tFAC06150 (Intellectual Product)\tregulation of short-day photoperiodism, flowering (Organism Function)\tdisease (or disorder); cranial nerve, third (Third cranial nerve finding)\tCLR457 (Antineoplastic Enzyme Inhibitor)", + "output": "Substance Use Sequence Number (Sequence Number)" + }, + { + "input": "Definition: Occupations described as a listing of occupations that don't fall under another major heading.\nConcepts: gynaecology (Reproductive Medicine)\tMiscellaneous Occupation (Occupation or Discipline)\tspinoreticular tract of the pons (Body Part, Organ, or Organ Component)\tIPA04-No Vigorous Physical Activities (Intellectual Product)\tStage I Gallbladder Cancer AJCC v7 (Gallbladder Cancer by AJCC v7 Stage)", + "output": "Miscellaneous Occupation (Occupation or Discipline)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the Bladder Control Scale for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: Grade 2 Chest wall pain (Finding)\tself-disclosure (Individual Behavior)\t(S)-malate:menaquinone oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor)\tBLCS01TC (CDISC Questionnaire Terminology)\tARTICULATOR DENT (Medical Device)", + "output": "BLCS01TC (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Pharmacologic Substance described as a benzenesulfonamide-based agent with salidiuretic and antihypertensive effects.\nConcepts: Glycosides, Iridoid (Iridoids)\tALPHA-2-MACROGLOBULIN, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tLog10 ELISA unit (Quantitative Concept)\tSITALIDONE (Diuretics)\tnecrosis (Liver)", + "output": "SITALIDONE (Diuretics)" + }, + { + "input": "Definition: Finding described as problem associated with a device sending or receiving signals or data. This includes transmission among internal components of the device to which the device is intended to communicate.\nConcepts: Communication or Transmission Problem (Device physical property issue)\trhEndostatin (Pharmacologic Substance)\tdown-regulation of retrograde trans-synaptic signaling by neuropeptide (negative regulation of signaling)\tBarcelona Clinic Liver Cancer Staging for Hepatocellular Carcinoma (Neoplastic Process)\tsclerotium development (anatomical structure development)", + "output": "Communication or Transmission Problem (Device physical property issue)" + }, + { + "input": "Definition: something described as human Oncogene N-RAS is a mutated variant of NRAS Gene (RAS Family), which encodes p21 N-Ras Protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. Oncogene NRAS disrupts normal cell function.\nConcepts: Garcinia morella / gambogia (Pharmacologic Substance)\tresponse to carbon dioxide (Cell Function)\tMachine smoke (Finding)\tOncogene N-RAS (Gene or Genome)\t5'-3' exoribonuclease activity (Genetic Function)", + "output": "Oncogene N-RAS (Gene or Genome)" + }, + { + "input": "Definition: rRNA processing described as any process involved in forming the mature 5' end of an rRNA molecule.\nConcepts: Endoscope Magnification Controllers (Controllers)\tIVD Test Reagent/Kits, Serology, Virus, Herpes Simplex 1, Antigen (Medical Device)\trRNA 5'-end processing (ncRNA 5'-end processing)\tFISTULA, ARTERIOVENOUS (Vascular)\tTumor Laterality Midline (CPTAC Responses)", + "output": "rRNA 5'-end processing (ncRNA 5'-end processing)" + }, + { + "input": "Definition: Intellectual Product described as works about scientific manuscripts made available prior to PEER REVIEW.\nConcepts: Neuronal Ceroid Lipofuscinosis, Parry Type (Neuronal Ceroid-Lipofuscinoses)\tsoft (General Qualifier)\tHomocitrulline Measurement (Amino acids measurement)\tMycobacterium haemophilum Sompolinsky et al. 1978 (Non-photochromogenic mycobacteria)\tTopic, Pre-Prints as (Intellectual Product)", + "output": "Topic, Pre-Prints as (Intellectual Product)" + }, + { + "input": "Definition: something described as a non-taxonomic grouping of bacteria that belongs to the intermedia/nigrescens group of the genus Prevotella.\nConcepts: Uncalcified osteoid (Prebone tissue)\taCD19z T cells (Cell)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, RET (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tPREVOTELLA INTERMEDIA/NIGRESCENS GROUP (Prevotella)\tRituximab-Methotrexate-Procarbazine-Vincristine (Therapeutic or Preventive Procedure)", + "output": "PREVOTELLA INTERMEDIA/NIGRESCENS GROUP (Prevotella)" + }, + { + "input": "Definition: Differentiated Thyroid Gland Carcinoma by AJCC v8 Stage described as a term that refers to the staging of papillary thyroid gland carcinoma, following the rules of the TNM AJCC v8 classification system.\nConcepts: Indigofera tinctoria / Indian maddar (Homeopathic remedies letter I)\tmitochondrial glycyl-tRNA aminoacylation (glycyl-tRNA aminoacylation)\tinclusion body assembly (cellular component assembly)\tThyroid Gland Papillary Carcinoma by AJCC v8 Stage (Differentiated Thyroid Gland Carcinoma by AJCC v8 Stage)\tanemias hemolytic immune (Anemia, Hemolytic, Acquired)", + "output": "Thyroid Gland Papillary Carcinoma by AJCC v8 Stage (Differentiated Thyroid Gland Carcinoma by AJCC v8 Stage)" + }, + { + "input": "Definition: something described as the region in the apical portion of multiciliated epithelial cells where the ciliary basal bodies cluster.\nConcepts: Juvenile Primary Lateral Sclerosis (Lateral Sclerosis)\ttrachea gland development (Organ or Tissue Function)\tbasal body patch (cellular anatomical entity)\tbody water dehydration (water balance disorders)\tDaily Activities (Thesaurus of Psychological Index Terms)", + "output": "basal body patch (cellular anatomical entity)" + }, + { + "input": "Definition: something described as successfully suckle breast for milk and appropriate behaviours and interactions with caregiver, such as eye contact, indicating need and satiation.\nConcepts: Lobule of lactiferous gland (Breast)\tCarrying out breast feeding (Drinking function)\t5 TIMES PER WEEK (Temporal Concept)\tPROTHROMBIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tReceptors, Peptide (Receptors, Cell Surface)", + "output": "Carrying out breast feeding (Drinking function)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of interferon present in a sample.\nConcepts: Erythrocyte Aggregation Analyzers (Medical Device)\tInterferon Measurement (Cytokine Measurement)\tTRB2 (Gene or Genome)\tDeleterious Arc-1 Gene Mutation (CDH1 Gene Mutation)\tStage IV Ovarian Embryonal Carcinoma AJCC v6 (Stage IV Ovarian Germ Cell Tumor AJCC v6 and v7)", + "output": "Interferon Measurement (Cytokine Measurement)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a C-reactive protein immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the C-reactive protein in serum and other body fluids. Measurement of C-reactive protein aids in evaluation of the amount of injury to body tissues.\nConcepts: C-REACTIVE PROTEIN, ANTIGEN, ANTISERUM, AND CONTROL (Indicator, Reagent, or Diagnostic Aid)\tFlapping tremor (Tremor)\tnarcolepsy disorder (Neurological Disorders)\tmicrowave spectrometry (Spectrometry)\thominis mycoplasmas (Mycoplasma)", + "output": "C-REACTIVE PROTEIN, ANTIGEN, ANTISERUM, AND CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Cell Component described as a homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators.\nConcepts: Severe combined immunodeficiency due to DNA-PKcs deficiency (Severe Combined Immunodeficiency)\tAF-1 domain binding (protein domain specific binding)\tcellular response to 2-sulfanylethanol (response to mercaptoethanol)\tTrisomy 4 (Disease or Syndrome)\tBCL-2 complex location (Bcl-2 family protein complex)", + "output": "BCL-2 complex location (Bcl-2 family protein complex)" + }, + { + "input": "Definition: cytokine production described as the appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.\nConcepts: Dilators, Surgical, Ureteral (Dilators, Surgical)\ttype I IFN production (cytokine production)\tAppendiceal Carcinoma Clinical Distant Metastasis TNM Finding v8 (Appendiceal Carcinoma Clinical TNM Finding v8)\tInfection Associated Nephrotic Syndrome (Disease or Syndrome)\tnucleobase-containing compound catabolic process (aromatic compound catabolic process)", + "output": "type I IFN production (cytokine production)" + }, + { + "input": "Definition: Cytotoxic T-Lymphocytes described as a preparation of lymphocytes harvested from a patient with an Epstein-Barr virus (EBV)-positive tumor. Ex vivo, the lymphocytes are activated against EBV-specific antigens and then returned to the patient, where they mount a specific immune response against EBV-positive tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28842\" active clinical trials using this agent.\nConcepts: Ensheathed tendon cluster (Heterogeneous anatomical cluster)\tAdenosine 5'-triphosphate (PURINES, PYRIMIDINES AND NUCLEIC ACIDS)\tglycosyl compound anabolism (glycosyl compound metabolic process)\tEBV-Specific Cytotoxic T-Lymphocyte (Cytotoxic T-Lymphocytes)\tKS (Geographic Area)", + "output": "EBV-Specific Cytotoxic T-Lymphocyte (Cytotoxic T-Lymphocytes)" + }, + { + "input": "Definition: Anatomical Abnormality described as an atrioventricular valve that has failed to open (atretic).\nConcepts: Unopened atrioventricular valve (Abnormal atrioventricular valve morphology)\tWD4S1 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tmmol/day (Unit of Amount of Substance Rate)\tregulation of neutrophil differentiation (Cell Function)\tPerichoroidal space (Interstitial space)", + "output": "Unopened atrioventricular valve (Abnormal atrioventricular valve morphology)" + }, + { + "input": "Definition: Intellectual Product described as performance of the Upper Limb Module for DMD 2.0 (PUL 2.0) Hand(s) to mouth.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, COL6A1 (Medical Device)\tPUL0207 (PUL 2.0 Functional Test Question)\tFDA Device Component Code Hierarchy (FDA Center For Devices and Radiological Health Terminology)\tATRX, Chromatin Remodeler Gene Mutation (Cell or Molecular Dysfunction)\tNEPHROPATHY DIABETIC (Kidney Diseases)", + "output": "PUL0207 (PUL 2.0 Functional Test Question)" + }, + { + "input": "Definition: Compartment of trunk described as compartment of trunk, which is embryologically derived from the intraembryonic celom; is located in the trunk, is enclosed by the body wall; contains serous sacs, viscera and other organs. Examples: There is only one body cavity.\nConcepts: RADIOIMMUNOASSAY, FOLLICLE-STIMULATING HORMONE (Indicator, Reagent, or Diagnostic Aid)\tCETABEN SODIUM (Pharmacologic Substance)\tStructure of body cavity and/or content (Compartment of trunk)\tIndexed Sequencing (Nucleic acid sequencing)\tLithotripters, Pneumatic (Lithotripters, Intracorporeal)", + "output": "Structure of body cavity and/or content (Compartment of trunk)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the upstream stimulatory factor is a ubiquitously expressed cellular transcription factor that binds to a symmetrical DNA sequence that is found in a variety of viral and cellular promoters. Purified USF consists of 2 related polypeptides of 43 and 44 kD encoded by USF1 and USF2, respectively. USF is known to be involved in the regulation of many gene with direct and indirect roles in cancer.\nConcepts: 4 Stair Descend (Functional assessment)\tIL-12p35 binding (interleukin-12 binding activity)\tGAGE-7 (LINC01194 gene)\tUSF Transcription Factors (Protein or Riboprotein Complex)\tMicrocapsules drug delivery system (Drug Delivery Systems)", + "output": "USF Transcription Factors (Protein or Riboprotein Complex)" + }, + { + "input": "Definition: something described as a membrane structure formed of two closely aligned lipid bilayers that lie beneath the plasma membrane and form part of the pellicle surrounding an apicomplexan parasite cell.\nConcepts: Technic, Cardiovascular Diagnostic (Diagnosis)\tHER1 c.2235 2252del18 (Cell or Molecular Dysfunction)\tNPS - Describe the Background Pain (Intellectual Product)\tSupports, Foot Arch (Healthcare supplies)\tinner membrane pellicle complex (Cell Component)", + "output": "inner membrane pellicle complex (Cell Component)" + }, + { + "input": "Definition: something described as chairs used to position the patient for easy access and comfort during examination, treatment, or minor surgical procedures. Most of these chairs are adjustable in height and include head, arm- and foot-rests, and a reclining back that may be tilted from a vertical to a horizontal or near-horizontal position. Some examination/treatment chairs are hydraulic or electrically powered.\nConcepts: Chairs, Examination/Treatment (Chairs)\tStage II Non-Contiguous Adult Indolent Non-Hodgkin Lymphoma (Stage II Indolent Adult Non-Hodgkin Lymphoma)\tPUMP, INFUSION, ELASTOMERIC (Medical Device)\tConjunctival Melanoma cT1c TNM Finding v8 (Conjunctival Melanoma cT1 TNM Finding v8)\tStage IVB Lip and Oral Cavity Squamous Cell Carcinoma (Stage IVB Lip and Oral Cavity Cancer AJCC v6 and v7)", + "output": "Chairs, Examination/Treatment (Chairs)" + }, + { + "input": "Definition: Finding described as transfusion indicated; invasive intervention indicated\nConcepts: Sample Export Documentation (Document type)\tGrade 3 Intestinal Stoma Site Bleeding, CTCAE (Finding)\ttapered (Structural modification)\tN-(2-Dimethylaminopropyl-1)phenothiazine Hydrochloride (Organic Chemical)\tnervous system infection (Disease or Syndrome)", + "output": "Grade 3 Intestinal Stoma Site Bleeding, CTCAE (Finding)" + }, + { + "input": "Definition: Growth Disorders described as an abnormal restriction of fetal growth with fetal weight below the tenth percentile for gestational age.\nConcepts: Monotony (Idea or Concept)\tprocreation (Reproductive Physiological Processes)\tFetal growth retardation, unspecified weight (Growth Disorders)\tEpididymal Papillary Cystadenoma (Neoplastic Process)\t19: 55965670-55966740 (Spatial Concept)", + "output": "Fetal growth retardation, unspecified weight (Growth Disorders)" + }, + { + "input": "Definition: Disorder of immune structure described as a rare inherited cancer-predisposing syndrome characterised by the development of a broad spectrum of malignancies during childhood, including mainly brain, haematological and gastrointestinal cancers, although embryonic and other tumours have also been occasionally reported. Non-neoplastic features, in particular manifestations reminiscent of neurofibromatosis type 1 (for example cafe au lait spots, freckling, neurofibromas), as well as premalignant and non-malignant lesions (such as adenomas/polyps) are frequently present before malignancy development.\nConcepts: Right lower lobe of lung (Structure of lower lobe of lung)\tpositive regulation of ribonucleoside-diphosphate reductase activity (Molecular Function)\tCMMR-D (Autosomal recessive hereditary disorder)\tMR Imaging Acquisition Protocol Element Saturation Recovery Indicator (Functional Concept)\tRetinal arteriolar tortuosity (Finding)", + "output": "CMMR-D (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: something described as a general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers.\nConcepts: Prostate, NOS (Prostate part)\tThaus (Asians)\tPartial/complete duplication of the middle phalanx of the 4th finger (Duplication of phalanx of 4th finger)\tSOLUTION, FORMALIN-ALCOHOL-ACETIC ACID (Indicator, Reagent, or Diagnostic Aid)\tregulation of gluconate membrane transport (regulation of anion transmembrane transport)", + "output": "SOLUTION, FORMALIN-ALCOHOL-ACETIC ACID (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Ferrous iron compound described as a form of mineral iron for oral administration, Ferrous Gluconate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes.\nConcepts: Activation-Inducible TNFR Family Receptor (Amino Acid, Peptide, or Protein)\tFerrous gluconate-containing product (Ferrous salt)\tHerpesvirus 6A, Human (Roseolovirus)\tProtein Hef Ortholog (Enzyme)\tcoenzyme Q biosynthetic process methyltransferase activity (Molecular Function)", + "output": "Ferrous gluconate-containing product (Ferrous salt)" + }, + { + "input": "Definition: Fungus described as a genus of white-spored mushrooms in the family Tricholomataceae. They form symbiotic partnerships (MYCORRHIZAE) with trees.\nConcepts: Knowledge: Dementia Management (Finding)\tSeemanova Lesny syndrome (Genetic Diseases, X-Linked)\tLaccaria Berk. & Broome, 1883 (Tricholomataceae)\tVirus-Related Lymphoma (Virus-Related Malignant Neoplasm)\tNegative Regulation of Mitosis (Mitosis)", + "output": "Laccaria Berk. & Broome, 1883 (Tricholomataceae)" + }, + { + "input": "Definition: Lymphoid leukemia in remission described as acute lymphoblastic leukemia not growing; responding to treatment.\nConcepts: APOA (Gene or Genome)\t1-Hydroxyvitamin D2 (Nephrogenic vitamin D preparation)\tAcute Lymphocytic Leukemia (Acute leukemia in remission)\tAbility to Rise from a Chair (Clinical or Research Assessment Question)\thost cell cytoplasm part (Cell Component)", + "output": "Acute Lymphocytic Leukemia (Acute leukemia in remission)" + }, + { + "input": "Definition: Idea or Concept described as an ADaM analysis dataset that doesn't conform to the ADSL or BDS structure.\nConcepts: nights (Temporal periods of day)\tCDISC Other ADaM Dataset (Data Set)\tFc-gamma receptor signalling pathway involved in phagocytosis (immune response-regulating cell surface receptor signaling pathway involved in phagocytosis)\tAutologous Antigens (Antigens)\tOrganic Cation Transporter-Like Protein 2 (Biologically Active Substance)", + "output": "CDISC Other ADaM Dataset (Data Set)" + }, + { + "input": "Definition: something described as arising from, pertaining to, or having two locations.\nConcepts: Bifocal (Focality)\tclinical outcome assessment (Intellectual Product)\tBranchio-Oto-Renal Syndrome (Congenital chromosomal disease)\tHereditary Cancer (Malignant Neoplasms)\tFrance (Affiliate Realms)", + "output": "Bifocal (Focality)" + }, + { + "input": "Definition: something described as the leaflet the plasma membrane at the cell tip that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface.\nConcepts: XANTHINOL NIACINATE (vitamin B complex)\tcytoplasmic side of plasma membrane, cell tip (internal side of plasma membrane)\tMedicated Sponge (Sponge Dosage Form)\tfast endocytic recycling (endocytic recycling)\tPTAP105F (Intellectual Product)", + "output": "cytoplasmic side of plasma membrane, cell tip (internal side of plasma membrane)" + }, + { + "input": "Definition: Cell Function described as migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell.\nConcepts: Mature Lymphocyte (Cell)\tGrade 4 Gallbladder obstruction (Gallbladder Obstruction, CTCAE)\tcns degenerative diseases (CNS disorder)\tnuclear migration to the embryo sac centre (Cell Function)\tModerate expressive language delay (Mental or Behavioral Dysfunction)", + "output": "nuclear migration to the embryo sac centre (Cell Function)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank (FACIT-Dyspnea Scale 33 Item Bank Version) Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking up 30 stairs (3 flights) without stopping.\nConcepts: White papule (Finding)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking Up 30 Stairs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tEGFRvIII Peptide Vaccine (Immunologic Factor)\tProcedure Kit/Trays, Anesthesia (Procedure Kit/Trays)\tHCT/P Satellite Recovery Facility (Manufactured Object)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walking Up 30 Stairs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Laboratory or Test Result described as a semi-quantitative microscopic finding indicating that 5-19 percent of the nucleated cells in a peripheral leukocyte sample are immature mononuclear cells.\nConcepts: Behavior modification assist (Therapeutic or Preventive Procedure)\tnitric oxide-cGMP-mediated signalling pathway (cGMP-mediated signaling)\tUsual Severity Nausea (Clinical or Research Assessment Question)\tChamberlain procedure (Therapeutic or Preventive Procedure)\tBlasts 5-19 Percent of Peripheral Blood White Cells (Laboratory or Test Result)", + "output": "Blasts 5-19 Percent of Peripheral Blood White Cells (Laboratory or Test Result)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of interleukin-6 secretion.\nConcepts: Unresectable Neuroblastoma (Unresectable Malignant Neoplasm)\tSolar Radiation (Electromagnetic Radiation)\tTP53 Nuclear Expression Intact (Finding)\tpositive regulation of IL-6 secretion (positive regulation of interleukin-6 production)\tNewborn follow-up physical examination and conference with parent in-office each 15 minutes (Newborn)", + "output": "positive regulation of IL-6 secretion (positive regulation of interleukin-6 production)" + }, + { + "input": "Definition: Muscle structure of pharynx described as a muscle originating from the outer sides of the thyroid and cricoid cartilages that is inserted into the pharyngeal raphe in the posterior portion of the wall of the pharynx and is innervated by the pharyngeal plexus. The cricopharyngeus muscle aids in swallowing by narrowing the lower part of the pharynx to move a bolus into the esophagus.\nConcepts: Boston University-Boston Medical Center Cancer Center (Consortium or Network)\tDisease May Have Normal Cell Origin (Idea or Concept)\tCricopharyngeus (Body Part, Organ, or Organ Component)\traspatory (Surgical Instruments)\tBacteria, Green Sulfur (Bacteria)", + "output": "Cricopharyngeus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as revised Fibromyalgia Impact Questionnaire - Go shopping for groceries.\nConcepts: Infliximab-containing product (Inflammatory bowel disease drug)\tTotal Thyroxine Level Finding (Laboratory test finding)\tFIQR - Go Shopping for Groceries (Intellectual Product)\tnegative regulation of protein K48-linked ubiquitination (regulation of protein K48-linked ubiquitination)\tIVD Test Reagent/Kits, Clinical Chemistry, Protein, Total, Urine (IVD Test Reagent/Kits, Clinical Chemistry, Protein, Total)", + "output": "FIQR - Go Shopping for Groceries (Intellectual Product)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's current ability to do their usual activities.\nConcepts: CooperativeGroup (Professional Organization or Group)\tMethanocaldococcus Whitman 2002 (Methanococcaceae)\tEquilibrium Phase Spiral CT (Phased Spiral CT)\tClinical Events Domain (Intellectual Product)\tDoing usual activities (Clinical or Research Assessment Question)", + "output": "Doing usual activities (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intellectual Product described as psoriasis Area and Severity Index (PASI) Upper Extremities (U): Desquamation (D).\nConcepts: PASI - Upper Extremities (U): Desquamation (Intellectual Product)\tpolarity specification of anterior/posterior axis (specification of axis polarity)\tVB10.16 vaccine (Immunologic Factor)\tAdrenocortical Carcinomas (Malignant neoplasm of endocrine gland)\tFursultiamin (Pharmacologic Substance)", + "output": "PASI - Upper Extremities (U): Desquamation (Intellectual Product)" + }, + { + "input": "Definition: something described as this gene is involved in antigen-specific immune responses and NK-cell clearance.\nConcepts: ICAM2 (Gene or Genome)\tHow Worried You Felt (Intellectual Product)\tIntercontinental (Population Group)\tIM oxidtv med admin.ea.Tx (Therapeutic or Preventive Procedure)\tResuscitation Training Manikins (Simulators, Training)", + "output": "ICAM2 (Gene or Genome)" + }, + { + "input": "Definition: Chronic myeloproliferative disorder described as a heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.\nConcepts: Meningeal Tumors (NCI CTEP SDC CNS Neoplasm (Primary Tumor) Category Terminology)\tStanding Frames, Mobile (Medical Device)\tTRICHURIS (Trichocephalus )\tcartilage shark (Pharmacologic Substance)\tSyndrome, Hypereosinophilic (Eosinophilia)", + "output": "Syndrome, Hypereosinophilic (Eosinophilia)" + }, + { + "input": "Definition: Carbohydrates described as synthetic pentasaccharide that mediates the interaction of HEPARIN with ANTITHROMBINS and inhibits FACTOR Xa; it is used for prevention of VENOUS THROMBOEMBOLISM after surgery.\nConcepts: SGRQ01-Coughing Makes Me Tired (Intellectual Product)\tFAC063-I Get Support From My Friends (Intellectual Product)\tRheumatologic Disorder (Collagen Diseases)\tjuvenile hormone catabolic process (Molecular Function)\tfondaparinux (Anticoagulants)", + "output": "fondaparinux (Anticoagulants)" + }, + { + "input": "Definition: Daily or Recreational Activity described as ability of a patient or subject to successfully perform tasks required for daily living.\nConcepts: CEFEPIME (Fourth generation cephalosporin)\tnegative regulation of neuron projection arborization (Cell Function)\tDifferentiation Stimulating Factor (Immunologic Factor)\tV1A vasopressin receptor binding (Vasopressin Receptor Binding)\tfunctions (Daily or Recreational Activity)", + "output": "functions (Daily or Recreational Activity)" + }, + { + "input": "Definition: Mi-2 Nucleosome Remodeling and Deacetylase Complex described as a retinoblastoma-binding protein that has an affinity for core HISTONES. It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2.\nConcepts: FAQ01-Paying Attention (FAQ Questionnaire Question)\tFAMILY AMBYSTOMIDAE (Urodela)\tSpending your usual amount of time practising or playing your instrument or sport (Clinical or Research Assessment Question)\tRetinoblastoma Binding Protein 7 (Polycomb Repressive Complex 2)\tH3 Protein Variant (Gene Product Sequence Variation)", + "output": "Retinoblastoma Binding Protein 7 (Polycomb Repressive Complex 2)" + }, + { + "input": "Definition: Myeloid Cells described as a cell found in peripheral blood, lymphoid tissue, and some inflamed tissue. It produces vast amounts of type I interferons especially in response to viruses, therefore playing an important role in antiviral immunity and triggers for adaptive immune responses.\nConcepts: CHSF2-Home Cognitive Assistance per Day (CHART-SF Paper Version Questionnaire Question)\tBONERESP (Finding)\tMillivolt Squared per Hertz (Unit of Electricity and Magnetism)\tLorazepam (Benzodiazepine derivative anxiolytics)\tCells, Plasmacytoid Dendritic (Myeloid Cells)", + "output": "Cells, Plasmacytoid Dendritic (Myeloid Cells)" + }, + { + "input": "Definition: Stress, Psychological described as in medicine, a term used to describe problems a patient has related to the cost of medical care. Not having health insurance or having a lot of costs for medical care not covered by health insurance can cause financial problems and may lead to debt and bankruptcy. Financial stress can also affect a patient's quality of life and access to medical care. For example, a patient may not take a prescription medicine or may avoid going to the doctor to save money. Cancer patients are more likely to have financial stress than people without cancer. Also called economic burden, economic hardship, financial burden, financial distress, financial hardship, and financial toxicity.\nConcepts: Embolization Bead (Embolic Agent)\tPULM VEIN (Veins)\tFinancial Pressure (Mental Process)\tup regulation of EGF receptor family signaling pathway (positive regulation of signal transduction)\tUndefined homeopathic remedy letter P narrative required (Homeopathic remedies letter P)", + "output": "Financial Pressure (Mental Process)" + }, + { + "input": "Definition: Disease or Syndrome described as a severe condition with onset in infancy of encephalomyopathy and in many cases renal tubulopathy. Manifestations include hypotonia, failure to thrive, microcephaly, and difficulty controlling head movement, delayed motor skills, serious breathing difficulties and can result in life-threatening respiratory failure. Most affected infants have lactic acidosis, which may also be life-threatening. Also associated are gastrointestinal dysmotility, seizures and sensorineural hearing loss. The disease is caused by mutations in the RRM2B gene which provides instructions for making one piece of the protein ribonucleotide reductase (RNR). RRM2B gene mutations reduce the activity or amount of RNR, which likely impairs production of mitochondrial DNA nucleotides. Inherited in an autosomal recessive pattern.\nConcepts: Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy (Mitochondrial DNA depletion syndrome encephalomyopathic form)\tCommon Lymphatic Endothelial and Vascular Endothelial Receptor-1 (Receptor)\tBody positioning education (Therapeutic or Preventive Procedure)\tPsychophysiological Disorder (Neurologic Manifestations)\tCutaneous spray, ointment (Topical Spray)", + "output": "Mitochondrial DNA depletion syndrome, encephalomyopathic form with renal tubulopathy (Mitochondrial DNA depletion syndrome encephalomyopathic form)" + }, + { + "input": "Definition: regulation of systemic arterial blood pressure by physical factors described as the intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs.\nConcepts: blood pressure regulation by stress relaxation (regulation of systemic arterial blood pressure by physical factors)\tUnresectable Digestive System Carcinoma (Gastrointestinal carcinoma)\t10q21-q22 (Chromosome band)\tFANCONI PANCYTOPENIA, TYPE 3 (Disease or Syndrome)\tsprouting of injured axon (Organ or Tissue Function)", + "output": "blood pressure regulation by stress relaxation (regulation of systemic arterial blood pressure by physical factors)" + }, + { + "input": "Definition: Head and Neck Part described as the portion of the hypopharynx that is located posteriorly to the larynx.\nConcepts: Lower Hypopharyngeal Region (hypopharynx)\tkidney excision (Procedures on Kidney)\tEthacrynic acid (Saluretic agent)\tImaging technique (Diagnostic Procedure)\tinjury to limb (Injury of musculoskeletal system)", + "output": "Lower Hypopharyngeal Region (hypopharynx)" + }, + { + "input": "Definition: something described as an RNA sample derived from a formalin-fixed paraffin-embedded tissue sample.\nConcepts: Hypopituitarism, CTCAE (Endocrine Disorders, CTCAE)\tFormalin-Fixed Paraffin-Embedded RNA (Nucleic Acid, Nucleoside, or Nucleotide)\tRadiation, Systemic (Therapeutic radiology procedure)\tTooth, Avulsed (Injury of periodontal tissue)\tdown regulation of protein localisation to cell tip (negative regulation of cellular protein localization)", + "output": "Formalin-Fixed Paraffin-Embedded RNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: something described as a prodrug of imidazotetrazine alkylating agent with antineoplastic property. Mitozolomide undergoes ring opening upon the nucleophilic attack at C-4 by an activated molecule of water within the major groove of DNA. The resulting bioactive mono-alkyltriazene species are capable of alkylating nucleophilic residues in the immediate vicinity such as N-7 and/or O-6 sites of guanine, thereby causes intra- or inter-stranded DNA cross-links and trigger apoptosis.\nConcepts: Microsporum persicolor (Class Ascomycetes)\tPseudoepiphyses of the proximal phalanges of the hand (Abnormality of the epiphyses of the proximal phalanges of the hand)\tImidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo- (Organic Chemical)\tPremedullary Cistern (Body Space or Junction)\tSGRQ Past 4 Weeks Version - Everything Too Much Effort (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)", + "output": "Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo- (Organic Chemical)" + }, + { + "input": "Definition: Epidemic described as widespread use of OPIOIDS by disproportionately large numbers of individuals within a population, community, or region occurring within a relatively narrow window of time.\nConcepts: Opioid Epidemic (Human-caused Phenomenon or Process)\tPIK3CA c.1624G>C (Cell or Molecular Dysfunction)\tmannoprotein biosynthesis (Molecular Function)\tlymphoma, diffuse small cleaved cell, adult (Neoplastic Process)\tFollistatin (INHIBIN)", + "output": "Opioid Epidemic (Human-caused Phenomenon or Process)" + }, + { + "input": "Definition: Adenocarcinoma described as a malignant epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Standard, Thyroid Hormone (IVD Test Reagent/Kits, Immunoassay, Standard)\tIntracranial Tumor Extension (Pathologic Function)\tIntermediate Ischemic Risk (Cardiac Ischemic Risk Score)\tTrabecular carcinoma (Adenoma AND/OR adenocarcinoma)\tCerebellar ataxia associated with quadrupedal gait (Gait abnormality)", + "output": "Trabecular carcinoma (Adenoma AND/OR adenocarcinoma)" + }, + { + "input": "Definition: Area Under Curve described as the observed area under the curve (AUC) extrapolated to infinity divided by the surface area.\nConcepts: FGFR3 p.Arg248Cys (FGFR3 Protein Variant)\tCOCCIGM (Laboratory Procedure)\tAllergy to dairy (IgE-mediated food allergy)\tAUC Infinity Obs Norm by SA (Quantitative Concept)\tC-SSRS Already Enrolled Subjects - Non-Specific Active Suicidal Thoughts (Intellectual Product)", + "output": "AUC Infinity Obs Norm by SA (Quantitative Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as a proprietary botanical formulation derived from a traditional Chinese medicinal (TCM) plant with hematopoietic activity. Although the mechanism of action has yet to be fully elucidated, plant-derived hematopoiesis enhancer PG2 appears to stimulate multi-lineage progenitor cells that may be closely related to the hematopoietic stem cell. In both chemotherapy- and radiation therapy-induced animal models of myelosuppression, this agent has been shown to restore granulocyte, erythrocyte, and platelet counts to normal levels. Plant-derived hematopoiesis enhancer PG2 stimulates the production of numerous cytokines such as granulocyte-colony stimulating factor (G-CSF) and may stimulate the production of neuroendocrine hormones. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C70640\" active clinical trials using this agent.\nConcepts: Ethmoid punch (Ear, nose and throat device)\tStage III Hodgkin's Disease (Neoplasm of lymph node)\tplant-derived hematopoiesis enhancer PG2 (Drug, Natural Product)\tHyperplastic callus formation (Anatomical Abnormality)\tMajor Salivary Gland Cancer cM0 TNM Finding v7 (Major Salivary Gland Cancer Clinical Distant Metastasis TNM Finding v7)", + "output": "plant-derived hematopoiesis enhancer PG2 (Drug, Natural Product)" + }, + { + "input": "Definition: A [Preparations] described as a chemical substance\nConcepts: Acetate (A [Preparations])\thistone H4 K20 methylation (Molecular Function)\tEEF1G Gene (Gene or Genome)\tBALSAM PERU OIL (Pesticides)\tbiomedical facility (Manufactured Object)", + "output": "Acetate (A [Preparations])" + }, + { + "input": "Definition: regulation of plasma cell differentiation described as any process that activates or increases the frequency, rate or extent of plasma cell differentiation.\nConcepts: Stage IV Duodenal Neuroendocrine Tumor (Duodenal Neuroendocrine Tumor by AJCC v8 Stage)\tbreedCode (HL7 Vocabulary Version 2.5)\tup regulation of plasma cell differentiation (regulation of plasma cell differentiation)\tmembrane tubulation (Cell Function)\tPROTHROMBIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "up regulation of plasma cell differentiation (regulation of plasma cell differentiation)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta.\nConcepts: Muscarinic Receptor Binding (Molecular Function)\tacidurias (Finding)\tnegative regulation of growth factor dependent skeletal muscle satellite cell proliferation (negative regulation of skeletal muscle satellite cell proliferation)\tCongenital posterior occipital alopecia (Congenital abnormal hair pattern)\tADMIO (STAT3 gene)", + "output": "negative regulation of growth factor dependent skeletal muscle satellite cell proliferation (negative regulation of skeletal muscle satellite cell proliferation)" + }, + { + "input": "Definition: Measurement Unit Description described as hour times picogram per milliliter, divided by milligram per gram.\nConcepts: Cells, Fat (Cell)\tLeptospermum (Leptospermeae)\tBiologic (Biological Science Disciplines)\t(mL/h)/(mg/m2/day) (Unit of Dose Calculation)\th*pg/mL/(mg/g) (Measurement Unit Description)", + "output": "h*pg/mL/(mg/g) (Measurement Unit Description)" + }, + { + "input": "Definition: Diagnostic Procedure described as a property of tissues such that a substance shows variable rates of diffusion in different spatial dimensions.\nConcepts: Dizziness (Dizziness and giddiness symptoms)\tRegulation of BAD phosphorylation (Molecular Function)\tEigenvalue (Quantitative Concept)\tA3 ADENOSINE RECEPTOR (G Protein-Coupled Receptor Genes)\tDiffusion MRI (Physical Phenomenon or Property)", + "output": "Diffusion MRI (Physical Phenomenon or Property)" + }, + { + "input": "Definition: Chemical categorised functionally described as an orally bioavailable 4-anilinoquinazoline. Vandetanib selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability. This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.\nConcepts: Medulloblastoma with extensive nodularity and advanced neuronal differentiation. (Primary malignant neoplasm)\tBlood Vessel Density (Diagnostic Procedure)\tImmunoglobulin G1, Anti-(Human Epidermal Growth Factor Receptor (Receptor Tyrosine-Protein Kinase ErbB-1, EC 2.7.10.1)); Human Monoclonal IMC-11F8 Gamma1 Heavy Chain (224-214')-Disulfide with Human Monoclonal IMC-11F8 Kappa Light Chain, Dimer (230- 230'':233-233'')-Bisdisulfide (Epidermal Growth Factor Receptor Antagonist [EPC])\tproton-dependent oligopeptide secondary active transmembrane transporter activity (Molecular Function)\tVandetanib (Angiogenesis Inhibitors)", + "output": "Vandetanib (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as a synapse consisting of a single presynapse and multiple postsynapses. These postsynapses may come from the same cell of from different cells. Polyadic synapses are common in arthropod and nematode central nervous systems.\nConcepts: Imaging, Molecular (Molecular Probe Techniques)\tSuppliers; Blood Bank (Health care facility)\t7,8-dihydroneopterin 3'-triphosphate synthesis (phosphate-containing compound metabolic process)\tpolyadic synapse (Body Space or Junction)\tstaphyloma posticum (Disease or Syndrome)", + "output": "polyadic synapse (Body Space or Junction)" + }, + { + "input": "Definition: Physiologic Function described as getting into and out of a body position and moving from one location to another, such as rolling from one side to the other, sitting, standing, getting up out of a chair to lie down on a bed, and getting into and out of positions of kneeling or squatting.\nConcepts: Tissue Perfusion: Peripheral (Tissue perfusion measure)\tIs Another NRAS Mutation Present (Presence of Another Mutation)\tUGT-1I (glycosyltransferase)\tChanging basic body position (Changing and maintaining body position)\tMSLOINC (LOINC Code)", + "output": "Changing basic body position (Changing and maintaining body position)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual performing chores such as housework, shopping groceries.\nConcepts: Performing Chores (Clinical or Research Assessment Question)\thyperargininemia (Urea Cycle Disorders, Inborn)\tAssociated Protein, Microtubule (Microtubule Proteins)\tFinAnaly Datsets (Data Set)\tShock, Neurogenic (Pathologic Function)", + "output": "Performing Chores (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: cytosol to endoplasmic reticulum transport described as the directed import of zinc(2+) from the cytosol, across the endoplasmic reticulum membrane, into the endoplasmic reticulum.\nConcepts: NT5C2 protein, human (Enzyme)\tCDISC Tuberculosis Therapeutic Area User Guide Version 2.0 (CDISC Therapeutic Area User Guide Name and Version)\tdemcizumab (Amino Acid, Peptide, or Protein)\tdownregulation of 2-methyl-1,3-butadiene metabolism (Molecular Function)\tzinc(2+) import into endoplasmic reticulum (zinc ion import into organelle)", + "output": "zinc(2+) import into endoplasmic reticulum (zinc ion import into organelle)" + }, + { + "input": "Definition: Leukocyte Abnormalities, General and NEC described as a clonal (malignant) hematopoietic disorder affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts). According to the type of blasts present, acute leukemias are classified as acute myeloid leukemia (AML) and precursor lymphoblastic or acute lymphoblastic leukemia (ALL). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9300\" active clinical trials using this agent.\nConcepts: central B cell anergy (Biologic Function)\tsteroid hormone receptor complex assembly (cellular protein-containing complex assembly)\tSelf-Care: Activities of Daily Living (Finding of functional performance and activity)\tAcute Leukemia (Malignant Neoplasms)\tKNIFE, LARYNGEAL (Ear, nose and throat knife)", + "output": "Acute Leukemia (Malignant Neoplasms)" + }, + { + "input": "Definition: Disorder of bilateral eyes described as increased pressure in both eyeballs due to obstruction of the outflow of aqueous humor.\nConcepts: Glaucoma of both eyes (Disorder of bilateral eyes)\tDDS0108 (T1-DDS Questionnaire Question)\tmillion units (Quantitative Concept)\tDate Pregnancy Ended (Date in time)\tTRAIL anabolism (cytokine biosynthesis)", + "output": "Glaucoma of both eyes (Disorder of bilateral eyes)" + }, + { + "input": "Definition: pole of kidney described as the pole of the kidney located in the uppermost region of the kidney.\nConcepts: Infection, Opisthorchis viverrini (Disease or Syndrome)\tFAC063-I Have Nausea (Intellectual Product)\tDosages (Property or Attribute)\tkidney pole upper (Kidney)\tAUTORECEPT (Receptors, Cell Surface)", + "output": "kidney pole upper (Kidney)" + }, + { + "input": "Definition: double-stranded DNA binding described as interacting selectively and non-covalently with double-stranded telomere-associated DNA.\nConcepts: NMP22 (Laboratory Procedure)\tHead and Neck Surgeon (Professional or Occupational Group)\tAcupuncture needle, single-use (Acupuncture/Acupressure device)\tDRRI1A12 (Intellectual Product)\tdouble-stranded telomeric DNA binding (double-stranded DNA binding)", + "output": "double-stranded telomeric DNA binding (double-stranded DNA binding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgical creation of an opening into the maxillary antrum.\nConcepts: Endoscopic examination of bladder (Pelvis endoscopy)\tDNA kinase activity (polynucleotide 5'-hydroxyl-kinase activity)\tCrystallins, alpha A Chain (alpha-Crystallins)\tantrostomies maxillary (Therapeutic or Preventive Procedure)\tTHEOL (Humanities)", + "output": "antrostomies maxillary (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Finding described as slowing in occipital areas of the scalp EEG.\nConcepts: Embryonic integumentary system (Other Embryologic Structure)\tcytidine triphosphatase activity (Molecular Function)\tIntrad papil adenoc+invason (Neoplasms, Ductal, Lobular, and Medullary)\tEEG with occipital slowing (EEG with focal slow activity)\tpotassium; excess (Disorder of fluid AND/OR electrolyte)", + "output": "EEG with occipital slowing (EEG with focal slow activity)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of L-dopa biosynthetic process.\nConcepts: Scleral staphyloma (Scleral Diseases)\tCluster of diff antigen 23 (Cell positive for CD23 antigen)\tprecorrin-2 C20-methyltransferase activity (Molecular Function)\ttelomeric D-loop disassembly (Genetic Function)\tregulation of L-dopa formation (regulation of cellular amino acid biosynthetic process)", + "output": "regulation of L-dopa formation (regulation of cellular amino acid biosynthetic process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione.\nConcepts: Powder for sealant (Biomedical or Dental Material)\tPANSS111 (Intellectual Product)\tmale germ-line stem cell population maintenance (Organism Function)\t17-alpha-hydroxyprogesterone aldolase activity (Molecular Function)\tSULFAPYRIDINE SODIUM (Pharmacologic Substance)", + "output": "17-alpha-hydroxyprogesterone aldolase activity (Molecular Function)" + }, + { + "input": "Definition: Foreign body on external eye described as external material in or on the cornea.\nConcepts: Global Alignment of Immunization safety Assessment in pregnancy Non-Reassuring Fetal Status Level of Diagnostic Certainty Terminology (GAIA Terminology)\tmaternal specification of dorsal/ventral axis, oocyte, germ-line encoded (Cell Function)\tVaginal Solutions (Pharmaceutical Solutions)\tAbnormal eyelid movement (Finding)\tCorneal surface FB (Effect of foreign body)", + "output": "Corneal surface FB (Effect of foreign body)" + }, + { + "input": "Definition: something described as a Native American language isolate spoken by the Washo people in the area of the California-Nevada border, especially around Lake Tahoe.\nConcepts: Bacteroides ruminicola subsp. brevus (Bacteroides)\tWasho (Hokan)\tBenign Pineal Area Tumor (Benign Supratentorial Neoplasms)\tAdrenoleucodystrophy (Adrenal Gland Diseases)\tDistorted sense of smell (Disorder of olfactory system)", + "output": "Washo (Hokan)" + }, + { + "input": "Definition: Chromaffin System described as neuroendocrine cells, found in the medulla of the adrenal gland and other sympathetic nervous system ganglia, that release catecholamines into circulation.\nConcepts: HLA-DO Histocompatibility Type, Beta Chain (Histocompatibility Antigens Class II)\tglyoxalase (glycolic acid-forming) activity (hydro-lyase activity)\tGranuloma annulare aggravated (Finding)\tChromaffin cell (Cells)\trHuKGF (Mucocutaneous Epithelial Cell Growth Factor)", + "output": "Chromaffin cell (Cells)" + }, + { + "input": "Definition: sterol binding described as interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol.\nConcepts: LACS2 (ACSL1 Gene)\tsterol sensor activity (sterol binding)\tProxy Without Assistance (Finding)\tMNDIAEVD (Cardiovascular finding)\tanterior neural tube closure (tube closure)", + "output": "sterol sensor activity (sterol binding)" + }, + { + "input": "Definition: Gastric Stenosis described as narrowing of the pyloric canal due to HYPERTROPHY of the surrounding circular muscle. It is usually seen in infants or young children.\nConcepts: Hepatitis C viruses (generic drug products begining with the letter H)\tAcetyldigoxins (Digitalis Glycosides)\tCongenital Constriction of the Pylorus (Congenital anomaly of stomach)\tDRRI1L15 (Intellectual Product)\tSerine Measurement (Amino acids measurement)", + "output": "Congenital Constriction of the Pylorus (Congenital anomaly of stomach)" + }, + { + "input": "Definition: cellular nitrogen compound catabolic process described as the chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).\nConcepts: Refractory Metastatic Pancreatic Adenocarcinoma (Refractory Pancreatic Adenocarcinoma)\talkaloid breakdown (cellular nitrogen compound catabolic process)\tHealth Care Professional (Report Source)\tIncreased neutrophil nuclear projections (Abnormality of neutrophil morphology)\tTesticular germ cell tumour mixed stage III (Malignant neoplasm of testis)", + "output": "alkaloid breakdown (cellular nitrogen compound catabolic process)" + }, + { + "input": "Definition: something described as any calcium-transporting ATPase activity that is involved in regulation of postsynaptic cytosolic calcium ion concentration.\nConcepts: Grade 2 Muscle Weakness Upper Limb, CTCAE (Muscle Weakness Upper Limb, CTCAE)\tATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration (Molecular Function)\tEGFR G719C (EGFR NP 005219.2:p.G719X)\tRadiography Image Plate Scanners (Diagnostic imaging equipment)\tMore Nervous Since Prostate Cancer Diagnosis (Intellectual Product)", + "output": "ATP phosphohydrolase (Ca2+-transporting) involved in regulation of postsynaptic cytosolic calcium ion concentration (Molecular Function)" + }, + { + "input": "Definition: Device Component or Accessory described as describes the use of a coated, thin, clear, glass or plastic fiber that can carry light and send information, including images. In medicine, flexible fiberoptic instruments are used to look inside the body. Fiberoptics are also used to deliver laser light to tumors injected with a type of drug that kills cancer cells when it is exposed to laser light.\nConcepts: Decreased serum progesterone (ENDOCRINE FEATURES)\tfiberoptic (Device Component or Accessory)\tMATEST (Intellectual Product)\tBlattella germanica IgE Antibody RAST Score Measurement (Immunoglobulin E measurement)\tMetered Dose Inhaler Dosage Form (Inhaler)", + "output": "fiberoptic (Device Component or Accessory)" + }, + { + "input": "Definition: therapeutic autologous lymphocytes described as a preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes (TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2; the therapeutic TILs are then infused into the patient, where, after re-infiltration of the tumor, they may induce lysis of tumor cells and tumor regression. The use of therapeutic TILs is considered a form of adoptive immunotherapy. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28699\" active clinical trials using this agent.\nConcepts: therapeutic tumor infiltrating lymphocytes (Cell)\tMERBROMIN (Mercurial antiseptic and disinfectant products)\tHypersegmentation of neutrophil nuclei in CSF (Abnormality of neutrophil morphology in CSF)\tRaf Kinase Inhibitor (Targeted Therapy Agent)\tCyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) Gene (Gene or Genome)", + "output": "therapeutic tumor infiltrating lymphocytes (Cell)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's ability to read books, magazines, or newspapers.\nConcepts: WHO Oral Mucositis Grade II (Oral Mucositis WHO Grading Scale)\tGNAQ Gene Expression Analysis (Biological Assay)\t(2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone (Medicinal product categorized by structure)\tChisels, Dental/Oral Surgery (Chisels, Dental)\tReading Ability question (Clinical or Research Assessment Question)", + "output": "Reading Ability question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: myo-inositol pentakisphosphate + H2O = myo-inositol tetrakisphosphate + phosphate.\nConcepts: Factorial Study (Clinical Study by Design)\tinositol pentakisphosphate phosphatase activity (inositol phosphate phosphatase activity)\tIVD Panels, Human Genetics, Multisystem Disorder, Oculocutaneous Disorder, Comprehensive (Medical Device)\tUstilagos (Fungus)\tPresume (Qualitative Concept)", + "output": "inositol pentakisphosphate phosphatase activity (inositol phosphate phosphatase activity)" + }, + { + "input": "Definition: Physical & Psychosomatic Disorders described as coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.\nConcepts: Pacemaker (Diagnostic Procedure)\torthophosphoric-monoester phosphohydrolase (Molecular Function)\tNasal Cavity and Ethmoid Sinus Cancer TNM Finding v6 (Finding)\tBladder Cancer pTis TNM Finding v8 (Bladder Cancer Pathologic Primary Tumor TNM Finding v8)\tCoronary Thrombosis (Coronary artery disorders NEC)", + "output": "Coronary Thrombosis (Coronary artery disorders NEC)" + }, + { + "input": "Definition: Malignant Neoplasms described as a malignant neoplasm that arises from mesothelial cells. It is associated with exposure to asbestos.\nConcepts: Mesothelioma, Malignant (Pleural Neoplasms)\tEXT1 (Neoplasm of uncertain behavior of bone)\tCHN (Geographic Area)\tCaldicellulosiruptor Rainey et al. 1995 emend. Onyenwoke et al. 2006 (Firmicutes)\tANTISERA, C. ACNES (Indicator, Reagent, or Diagnostic Aid)", + "output": "Mesothelioma, Malignant (Pleural Neoplasms)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as a terminology codelist relevant to the course by which a substance is administered in order to reach the site of action in the body.\nConcepts: detection of nodal flow (Cell Function)\tPCHGBL (Percent)\tSDTM-ROUTE (CDISC SDTM Terminology)\tHour Times Mole per Liter per Kilogram per Meter Squared (Measurement Unit Description)\tregulation of imaginal disc growth (regulation of multicellular organismal development)", + "output": "SDTM-ROUTE (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Organism Function described as the process in which the lambdoid suture is generated and organized.\nConcepts: lambdoid suture morphogenesis (cranial suture morphogenesis)\tmedicine tablets (Dosage Forms)\ttRNA end turnover (Genetic Function)\tERYTHROCYTE SUSPENSION, MULTI SPECIES, SEROLOGICAL REAGENT AND EQUIPMENT (Medical Device)\tsuperior colliculus, sensory related (Body Part, Organ, or Organ Component)", + "output": "lambdoid suture morphogenesis (cranial suture morphogenesis)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a miconazole stimulus.\nConcepts: Risk For Impaired Peripheral Neurovascular Function (Physical injury)\tPlatelet Factor 4-Heparin Complex Induced Antibody Measurement (Laboratory Procedure)\tWard, General (Health Care Related Organization)\tresponse to miconazole (Organism Function)\tSodium thiosulfate product (Antidote)", + "output": "response to miconazole (Organism Function)" + }, + { + "input": "Definition: something described as mexican mint.\nConcepts: plectranthus fruticosus/mexi (Pharmacologic Substance)\tImmunostimulants (Mediator of immune response)\thsa-let-7a-3 (MIRLET7A3 gene)\tImmunological Tolerance (Immune response)\tGastric Carcinoma by AJCC v8 Stage (Neoplastic Process)", + "output": "plectranthus fruticosus/mexi (Pharmacologic Substance)" + }, + { + "input": "Definition: Stage I Soft Tissue Sarcoma AJCC v7 described as stage IB includes: (T2a, N0, M0, G1, GX); (T2b, N0, M0, G1, GX). T2a: Superficial tumor more than 5 cm in greatest dimension. T2b: Deep tumor more than 5 cm in greatest dimension. N0: No regional lymph node metastasis. M0: No distant metastasis. G1: Grade 1. GX: Grade cannot be assessed. (AJCC 7th ed.) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8580\" active clinical trials using this agent.\nConcepts: Glottic Cancer TNM Finding v6 (Finding)\tautophagy related 16 like 1 (Gene or Genome)\tTunneled Pleural Catheter Drainage (Therapeutic or Preventive Procedure)\tstage IB soft tissue sarcoma AJCC v7 (Neoplastic Process)\tcefepime (C [Preparations])", + "output": "stage IB soft tissue sarcoma AJCC v7 (Neoplastic Process)" + }, + { + "input": "Definition: regulation of oxidoreductase activity described as any process that modulates the frequency, rate or extent of succinate dehydrogenase activity.\nConcepts: Leukosialin (Binding Proteins)\tBLASTIMM (Cell Count)\tregulation of fumaric hydrogenase activity (Molecular Function)\tMetastatic Clear Cell Renal Cell Carcinoma (Metastatic Renal Cell Carcinoma)\tMethylophilus methylitrophus (Methylophilus)", + "output": "regulation of fumaric hydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: negative regulation of neurogenesis described as any process that stops, prevents, or reduces the frequency, rate or extent of neuron differentiation.\nConcepts: butyryl-CoA-acetoacetate CoA-transferase activity (CoA-transferase activity)\tBrain Cancer (Malignant Head and Neck Neoplasm)\tdown-regulation of neuron differentiation (negative regulation of neurogenesis)\tADNI AVLT - List A Recall 1 Word 7 (ADNI-AVLT Questionnaire Question)\tSki complex (protein-containing complex)", + "output": "down-regulation of neuron differentiation (negative regulation of neurogenesis)" + }, + { + "input": "Definition: Cell Component described as the portion of the extracellular matrix that lies within the synaptic cleft.\nConcepts: URI1, Prefoldin Like Chaperone Gene (Gene or Genome)\tsynaptic cleft ECM (Cell Component)\tsecondary intermediate sulcus (Body Space or Junction)\tRADIAL HEADS, POSTERIOR DISLOCATION OF (Dislocation of radial head)\tCDISC Questionnaire DAD Test Name Terminology (CDISC Questionnaire Terminology)", + "output": "synaptic cleft ECM (Cell Component)" + }, + { + "input": "Definition: Existing client in-office without ICD diagnosis described as using Native American Healing assessment methods in a comprehensive, subsequent, 60-minute, in-office meeting to assess the health status of an existing Native American Healing client to reevaluate and/or develop a Native American Healing treatment plan.\nConcepts: SNF2L4 (SMARCA4 gene)\tMenometrorrhagia (finding) [Ambiguous] (Metrorrhagia)\tPRR2 (Cell Adhesion Molecule Gene)\tsbsqnt60min inofc NatAm ntak (Health Care Activity)\tPUL01-Supination (Intellectual Product)", + "output": "sbsqnt60min inofc NatAm ntak (Health Care Activity)" + }, + { + "input": "Definition: Pharmacologic Substance described as great yellow wolfsbane.\nConcepts: CDISC-OBSCLS (Clinical Data Interchange Standards Consortium Terminology)\tISTESTCD (CDISC SDTM Terminology)\tEndocervical Route of Administration (RouteBySite)\tleukotriene B4 12-hydroxy dehydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)\tAconitum lycotonum / great yellow wolfsbane (Homeopathic remedies letter A)", + "output": "Aconitum lycotonum / great yellow wolfsbane (Homeopathic remedies letter A)" + }, + { + "input": "Definition: pyrimidine analog described as an antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.\nConcepts: Ayurvedic shaman fresh air each 15 minutes (Health Care Activity)\tNon Hodgkin's Lymphoma (Malignant lymphoma, diffuse)\tFormerly Used Menopausal Hormone Therapy (CPTAC Responses)\t1-(2-deoxy-beta-D-ribofuranosyl)-5-fluorouracil (Pharmacologic Substance)\t35-64 years old (Adult)", + "output": "1-(2-deoxy-beta-D-ribofuranosyl)-5-fluorouracil (Pharmacologic Substance)" + }, + { + "input": "Definition: regulation of aggregation involved in sorocarp development described as any process that increases the frequency, rate or extent of aggregation involved in sorocarp development. Aggregation involved in sorocarp development is the process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.\nConcepts: Gastric Neuroendocrine Tumor Clinical Distant Metastasis TNM Finding v8 (Finding)\tpositive regulation of aggregation involved in sorocarp development (regulation of aggregation involved in sorocarp development)\tEOR0206 (Intellectual Product)\tAgrammatic Broca Aphasias (Aphasia, Expressive)\tComplete abortion (Disorder of product of conception)", + "output": "positive regulation of aggregation involved in sorocarp development (regulation of aggregation involved in sorocarp development)" + }, + { + "input": "Definition: BPRS-A Clinical Classification Question described as brief Psychiatric Rating Scale-A (BPRS-A) Somatic concern.\nConcepts: Masson trichrome stain method (Trichrome stain method)\tNK T lymphocyte activation (Cell Function)\tHereditary palmoplantar keratoderma Gamborg Nielsen type (Keratoderma, Palmoplantar, Diffuse)\tScreens for physical abuse (Screening for abuse)\tBPRSA1-Somatic Concern (Intellectual Product)", + "output": "BPRSA1-Somatic Concern (Intellectual Product)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of cyclophosphamide that may be used in the treatment of anaplastic gliomas and glioblastomas; and ovarian, fallopian tube, primary peritoneal and breast cancers.\nConcepts: AMANOZINE (Diuretics)\tAspirin (taking medication)\tSublumbar Lymph Node (Experimental Organism Anatomical Concept)\tLeifsonia Evtushenko et al. 2000 emend. Reddy et al. 2008 (Microbacteriaceae)\tCyclophosphamide Regimen (Regimen Used to Treat Breast Carcinoma)", + "output": "Cyclophosphamide Regimen (Regimen Used to Treat Breast Carcinoma)" + }, + { + "input": "Definition: Conjunctival Melanoma Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of conjunctival melanoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.\nConcepts: X: 133319777-133360216 (Chromosome X Physical Location)\testablishment of endothelial intestinal barrier (Cell Function)\tHelium (Helium and its derivatives)\tRET Rearrangement Analysis Was Not Performed (Testing Was Not Preformed)\tConjunctival Melanoma Pathologic Distant Metastasis TNM Finding v8 (Conjunctival Melanoma Pathologic TNM Finding v8)", + "output": "Conjunctival Melanoma Pathologic Distant Metastasis TNM Finding v8 (Conjunctival Melanoma Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Disease or Syndrome described as abnormally low concentrations of vitamin C in the blood.\nConcepts: Benzenesulfonic acid, 5-(acetylamino)-2-(2-(4-isothiocyanato-2-sulfophenyl)ethenyl)- (Indicator, Reagent, or Diagnostic Aid)\tScorbutus (Vascular Hemostatic Disorders)\tMSQL104 (MSQOL-54 Questionnaire Question)\tpositive regulation of hepatic stellate cell migration (regulation of hepatic stellate cell migration)\tRegimen Used to Treat Vulvar Cancer (Therapeutic or Preventive Procedure)", + "output": "Scorbutus (Vascular Hemostatic Disorders)" + }, + { + "input": "Definition: Agaricaceae described as a basidiomycetous fungal genus of the family Agaricaceae, order Agaricales, which includes the field mushroom (A. campestris) and the commercial mushroom (A. bisporus).\nConcepts: Stage IIIB Vulvar Carcinoma AJCC v8 (Stage III Vulvar Cancer AJCC v8)\tAgaricus (Fungus)\tGrade II Colon Adenocarcinoma (Grade 2 Colorectal Adenocarcinoma)\tMultifactor Dimensionality Reductions (Intellectual Product)\tX-Ray Filter Thickness Minimum (Thick)", + "output": "Agaricus (Fungus)" + }, + { + "input": "Definition: Signaling Protein described as SH2 domain-containing protein 1B (132 aa, ~15 kDa) is encoded by the human SH2D1B gene. This protein plays a role in the regulation of receptor signaling.\nConcepts: ISGF3 protein, human (Biologically Active Substance)\tSIQR - Depression (Intellectual Product)\tStage IIIB Rectal Cancer AJCC v8 (Neoplastic Process)\tSH2 domain containing 1B protein, human (Biologically Active Substance)\tdownregulation of mitotic recombination (negative regulation of DNA recombination)", + "output": "SH2 domain containing 1B protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Vision Disorders NEC described as an absolute or relative reduction in the extent of the normal field of vision.\nConcepts: fistula external (pathologic fistula)\tcomplement activation, alternative pathway (Complement Pathway, Alternative)\tnegative regulation of histone H3-K4 acetylation (Molecular Function)\tcytokine receptor (Receptor)\tLoss of visual fields (Vision Disorders)", + "output": "Loss of visual fields (Vision Disorders)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-deoxystreptamine + UDP-alpha-D-glucose <=> 2'-deamino-2'-hydroxyparomamine + UDP(3-) + H+.\nConcepts: Pericardial Mesothelioma (Abnormal pericardium morphology)\tcytokinin binding (hormone binding)\tElectrodes, Electrocardiographic, Neonatal (Medical Device)\tpositive regulation of transcription from Pol II promoter involved in noradrenaline biosynthetic process (Genetic Function)\t2-deoxystreptamine glucosyltransferase activity (hexosyltransferase activity)", + "output": "2-deoxystreptamine glucosyltransferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: Tissue described as a protein complex which is capable of methionine-importing activity.\nConcepts: Can you go shopping for groceries or clothes (Intellectual Product)\tReceptor, G-CSF (Receptors, Colony-Stimulating Factor)\tPostganglionic Autonomic Fibers (Autonomic Pathways)\tmethionine-importing complex location (Tissue)\tPrimitive Neuroectodermal Tumor of Spinal Cord (Malignant neoplasm of spinal cord)", + "output": "methionine-importing complex location (Tissue)" + }, + { + "input": "Definition: Diagnosis described as determination of the presence of disease(s) or abnormal state of the immune system or the distinguishing of one disease or condition from another based on symptoms, medical history, risk factors, and clinical tests.\nConcepts: CDISC Clinical Classification QIDS-C Test Code Terminology (Intellectual Product)\tregulation of c-di-GMP signaling (regulation of signaling)\tPSCTK1 Gene Mutation (Cell or Molecular Dysfunction)\tKnight's disease (Disorder of skin AND/OR subcutaneous tissue of trunk)\timmunopathology diagnosis (Diagnosis)", + "output": "immunopathology diagnosis (Diagnosis)" + }, + { + "input": "Definition: Deletion of part of long arm of chromosome 17 described as a very rare chromosomal disorder of unknown prevalence with characteristics of multiple craniofacial (microcephaly and eye, ear, and nose deformities), limb and other multiple organ abnormalities, growth and motor retardation and intellectual deficit. The syndrome is frequently lethal. The deletions include 17(q21.3q23), 17(q21.3q24.2), 17(q23.q24.3) and 17(q23.1q24.2).\nConcepts: Central Nervous System Mesenchymal Chondrosarcoma (sarcoma of central nervous system)\tAspalathus (Crotalarieae)\tTelomeric deletion 17q (Anomaly of chromosome pair 17)\tnitrobenzoate nitroreductase activity (Molecular Function)\tSerum Globulin (Serum, Urine and Miscellaneous Proteins)", + "output": "Telomeric deletion 17q (Anomaly of chromosome pair 17)" + }, + { + "input": "Definition: Geographic Area described as a country in Southeastern Asia, northeast of Thailand, west of Vietnam. The capital is Vientiane.\nConcepts: Protoplast (Cells)\tSomeone You Can Count On to Listen to You When You Need to Talk (Findings-Based Question)\tpositive regulation of cyclodextrin catabolic process (positive regulation of catabolic process)\tNonlipid reticuloendotheliosis [obs] (Langerhans Cell Histiocytosis, Disseminated)\tLAO (Geographic Area)", + "output": "LAO (Geographic Area)" + }, + { + "input": "Definition: something described as stage I includes: IA: (T1, N0, M0) and IB: (T1, N1, M0); (Ta/b, N0, M0). T1: Tumor invades lamina propria or submucosa. T2: Tumor invades the muscularis propria or the subserosa. T2a: Tumor invades muscularis propria. T2b: Tumor invades subserosa. N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes. N2: Metastasis in 7 to 15 regional lymph nodes. M0: No distant metastasis.\nConcepts: CSS0713 (Intellectual Product)\tStage I Carcinoma of Stomach AJCC v6 (Gastric Cancer by AJCC v6 Stage)\tnerve disorders (Nerve, nerve root and plexus disorders)\tpreschools (Educational Status)\tnonhomologous end-joining factor 1 (Gene or Genome)", + "output": "Stage I Carcinoma of Stomach AJCC v6 (Gastric Cancer by AJCC v6 Stage)" + }, + { + "input": "Definition: Pharmacologic Substance described as brand name of methazole herbicide\nConcepts: CDISC SDTM Medical Evaluator Terminology (Intellectual Product)\tSODIUM MOLYBDATE (Molybdenum compound)\tPVA Microporous Hydrospheres/Doxorubicin Hydrochloride (Pharmacologic Substance)\tNCI CTEP SDC CNS Neoplasm (Primary Tumor), Miscellaneous Sub-Category Terminology (Intellectual Product)\tprobe [brand name] (Organic Chemical)", + "output": "probe [brand name] (Organic Chemical)" + }, + { + "input": "Definition: Tuberculosis, Renal described as infection of the KIDNEY with species of MYCOBACTERIUM.\nConcepts: PQL13-Feel Tired (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)\tLow grade (Severity of illness)\tRenal Tuberculoses (Kidney finding)\tcephadroxyl (Antibiotics)\tPODCI324 (Intellectual Product)", + "output": "Renal Tuberculoses (Kidney finding)" + }, + { + "input": "Definition: something described as functional Assessment of Multiple Sclerosis - General Contentment: I am content with the quality of my life right now.\nConcepts: transposase activity (Molecular Function)\tCDISC Parkinson's Disease Therapeutic Area User Guide Version 1.0 (Intellectual Product)\tPectinatus Lee et al. 1978 (Approved Lists 1980) emend. Caldwell et al. 2013 (Selenomonadaceae)\tnasal cavity and paranasal sinus cancer, stage I (stage, paranasal sinus and nasal cavity cancer)\tFAMS0125 (Intellectual Product)", + "output": "FAMS0125 (Intellectual Product)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of mass flow rate equal to one microgram per hour.\nConcepts: Microgram per Hour (Unit of Mass Flow Rate)\tiodine I 131 MOAB 81C6 (Amino Acid, Peptide, or Protein)\tN-(aminoiminomethyl)-N-methylglycine (Amino acid derivative)\tVINYL CPDS (Alkenes)\tBashkortostan (Geographic Area)", + "output": "Microgram per Hour (Unit of Mass Flow Rate)" + }, + { + "input": "Definition: something described as chemic or hemorrhagic stroke resulting from cerebral venous thrombosis.\nConcepts: cyclization of glutamine involved in intein-mediated protein splicing (glutamine metabolism)\tCerebral Venous Stroke (Pathologic Function)\tPedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report - Wake Up Tired (Intellectual Product)\tchoroid; inflammation (Choroidal and/or chorioretinal disorder)\tdemcizumab (Amino Acid, Peptide, or Protein)", + "output": "Cerebral Venous Stroke (Pathologic Function)" + }, + { + "input": "Definition: Nursing Assessment Entity described as watery bowel movements.\nConcepts: watery stool (Systemic allergic response status)\tdownregulation of beta1-adrenergic receptor activity (negative regulation of signaling receptor activity)\tPremarket Approval (Regulatory Application)\tN1mi Stage Finding (Finding)\tIVD Panels, Human Genetics, Neurodegenerative Disorder, Dementia, Alzheimer, Del/Dup (Medical Device)", + "output": "watery stool (Systemic allergic response status)" + }, + { + "input": "Definition: something described as various physiological or molecular disturbances that impair ENDOPLASMIC RETICULUM function. It triggers many responses, including UNFOLDED PROTEIN RESPONSE, which may lead to APOPTOSIS; and AUTOPHAGY.\nConcepts: Stresses, Endoplasmic Reticulum (Cell physiology)\tAnalgesic Administration: Intraspinal (drug management)\tMycobacterium, non-TB (unclassified Mycobacteriaceae)\tDVREFID (Intellectual Product)\tTotal Clearance Predicted by Fraction Dose Normalized by Surface Area (Predicted Total Body Clearance by Fraction of Dose Absorbed)", + "output": "Stresses, Endoplasmic Reticulum (Cell physiology)" + }, + { + "input": "Definition: intramolecular lyase activity described as catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate.\nConcepts: Organ of Corti (Ear part)\tANTISERUM, CF, LYMPHOCYTIC CHORIOMENINGITIS VIRUS (Indicator, Reagent, or Diagnostic Aid)\tElevated Scatter Factor Receptor Protein Expression (Finding)\tpenetration hypha formation (Organism Function)\t4-carboxymethyl-4-hydroxyisocrotonolactone lyase (Molecular Function)", + "output": "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (Molecular Function)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of huntingtin protein present in a sample.\nConcepts: downregulation of post-embryonic development (negative regulation of multicellular organismal process)\tUDP-D-apiose biosynthetic process (nucleotide-sugar biosynthetic process)\tHuntingtin Protein (Laboratory Procedure)\tPregnancy, Unintended (Finding)\tCruciferous vegetable (Food)", + "output": "Huntingtin Protein (Laboratory Procedure)" + }, + { + "input": "Definition: Genus staphylococcus described as any bacterial organism that can be assigned to the species Staphylococcus carnosus.\nConcepts: Stage IVB Oral Cavity Squamous Cell Carcinoma AJCC v6 (Squamous cell carcinoma of the oral cavity stage IV)\tdendritic spine neck (Cell Component)\tCardiac Valves, Mechanical (Medical Device)\tStaphylococcus carnosus (Staphylococcus, coagulase negative)\tMeter Squared per Second (Quantitative Concept)", + "output": "Staphylococcus carnosus (Staphylococcus, coagulase negative)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of two ( Swanson-2004 ) or three ( Paxinos-2009b ) subdivisions of the basolateral nucleus of the amygdala identified by Nissl stain in the rat. The second, reported by both authors, is the posterior part of the basolateral nucleus. The third, if present, is the ventral part of the basolateral nucleus. All three are reported in the mouse ( Dong-2004; Franklin-2008 ).\nConcepts: anterior part of the basolateral amygdalar nucleus (Body Part, Organ, or Organ Component)\tCanton and Enderbury Islands (Country)\tKetone Body Measurement (Laboratory Procedure)\tUHDR156 (Intellectual Product)\tEndocrine gland functions (Physiologic Function)", + "output": "anterior part of the basolateral amygdalar nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as the liposomal preparation of oxaliplatin, an organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group'. A leaving group is an atom or a group of atoms that is displaced as a stable species taking with it its bonding electrons. After displacement of the labile oxalate ligand leaving group, the active oxaliplatin derivatives (monoaquo and diaquo DACH platinum) alkylate macromolecules, and form both inter- and intra-strand platinum-DNA crosslinks, thereby inhibiting DNA replication and resulting in cytotoxicity. The DACH side chain appears to inhibit DNA repair mechanism, therefore overcoming the limits observed in other platinum-based therapies.\nConcepts: Stage IIIA Colorectal Cancer AJCC v7 (Neoplastic Process)\tglycolytic process through fructose-6-phosphate (Molecular Function)\tLiposomal Oxaliplatin (Platinum Antineoplastic Compound)\tComplete duplication of the innermost bones of the hand (Anatomical Abnormality)\tnuc ish(13q14x1)[60]/(13q14x2)[40] (Finding)", + "output": "Liposomal Oxaliplatin (Platinum Antineoplastic Compound)" + }, + { + "input": "Definition: Cell Cycle Proteins described as a member of the Rho family of MONOMERIC GTP-BINDING PROTEINS. It is associated with a diverse array of cellular functions including cytoskeletal changes, filopodia formation and transport through the GOLGI APPARATUS. This enzyme was formerly listed as EC 3.6.1.47.\nConcepts: nitrates (nitric acid)\tretinotectal tract (Body Part, Organ, or Organ Component)\tTachyarrhythmia terms, nonspecific (Classification)\tCGI Original Version - Efficacy Index (CGI Original Version Questionnaire Question)\tp21 cdc42 (Amino Acid, Peptide, or Protein)", + "output": "p21 cdc42 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a carbon monoxide gas analyzer is a device intended to measure the concentration of carbon monoxide in a gas mixture to aid in determining the patient's ventilatory status. The device may use techniques such as infrared absorption or gas chromatography.\nConcepts: nipple morphogenesis (Morphogenesis)\tCarbon monoxide analyzer (Blood gas/pH analyzer)\tOvum Protein (Amino Acid, Peptide, or Protein)\tMyeloma, Smoldering (Paraproteinemias)\tLikert Scale 7-Point (Likert scale)", + "output": "Carbon monoxide analyzer (Blood gas/pH analyzer)" + }, + { + "input": "Definition: Cell described as a cell-based vaccine consisting of autologous HLA-A2*0201-restricted dendritic cells (DC), which were derived from patient-harvested adherent peripheral blood monocytes cultured in vitro with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), that were pulsed with a peptide fragment comprised of amino acid residues 26 through 35 of melanoma antigen recognized by T cells 1 (MART-1 (26-35)), with potential immunostimulatory and antineoplastic activities. Upon intradermal vaccination, autologous DC pulsed with MART-1 (26-35) peptide may stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1. MART-1, a protein involved in melanosome biogenesis, is overexpressed by melanoma cells. The MART-1 (26-35) peptide is highly immunogenic for the HLA-A2*0201 haplotype. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C142814\" active clinical trials using this agent.\nConcepts: autologous MART-1 (26-35) peptide pulsed DC vaccine (Cell)\tBlocking of thoughts (Flow of thought)\tManual scar therapy each treatment (Therapeutic or Preventive Procedure)\tTesticular choriocarcinoma (Testicular and epididymal neoplasms)\tNeonatal pneumothorax (Finding)", + "output": "autologous MART-1 (26-35) peptide pulsed DC vaccine (Cell)" + }, + { + "input": "Definition: Cardiac therapeutic procedures NEC described as diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.\nConcepts: N-terminal peptidyl-proline N-formylation (N-terminal protein formylation)\tdetection of steroid hormone stimulus (response to steroid hormone)\t7SK small nuclear RNA binding (snRNA binding)\tBypasses, Cardiopulmonary (Cardiovascular system repair)\tHematopoietic Cell Donor Eligibility (Qualitative Concept)", + "output": "Bypasses, Cardiopulmonary (Cardiovascular system repair)" + }, + { + "input": "Definition: Neoplastic Process described as a pathologic process that involves the transformation of normal cells to a neoplastic state and resulting in polyclonal or monoclonal neoplastic cell proliferation.\nConcepts: CRYBG1 wt Allele (Gene or Genome)\tVery hard (Intellectual Product)\tatrazine metabolism (Molecular Function)\tNeoplastic Cell Transformations (Neoplastic Processes)\tVNP 20009 (Bacterium)", + "output": "Neoplastic Cell Transformations (Neoplastic Processes)" + }, + { + "input": "Definition: Phosphatidylinositide 3-Kinase Inhibitor described as an orally bioavailable inhibitor of the class I phosphoinositide 3-kinase (PI3K) alpha and beta isoforms with potential antineoplastic activity. PI3K alpha/beta inhibitor BAY1082439 selectively inhibits both PI3K alpha, including mutated forms of PIK3CA, and PI3K beta in the PI3K/Akt/mTOR pathway, which may result in tumor cell apoptosis and growth inhibition in PI3K-expressing and/or PTEN-driven tumor cells. By specifically targeting class I PI3K alpha and beta, this agent may be more efficacious and less toxic than pan PI3K inhibitors. Dysregulation of the PI3K/Akt/mTOR pathway is frequently found in solid tumors and results in increased tumor cell growth, survival, and resistance to chemotherapy and radiotherapy. PIK3CA, one of the most highly mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. PTEN, a tumor suppressor protein and negative regulator of PI3K activity, is often mutated in a variety of cancer cells.\nConcepts: Stage IVA Epidermoid Carcinoma of the Oropharynx (Neoplastic Process)\tSerpin (Protease inhibitor protein)\t11: 49186798-49124764 (Chromosome 11 Physical Location)\tPI3K Alpha/Beta Inhibitor BAY1082439 (Antineoplastic Enzyme Inhibitor)\tReceptor, Melanocortin-1 (Receptor)", + "output": "PI3K Alpha/Beta Inhibitor BAY1082439 (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Cellular Assay described as a set of laboratory assays that examine the responses of lymphoid or myeloid cells after exposure to an experimental material.\nConcepts: GISA or hGISA detected (Finding)\tImmune Cell Function (Cellular Assay)\tPRESHT (Temporal Concept)\trndx tobacco abuse (Mental or Behavioral Dysfunction)\tVosaroxin (Pharmacologic Substance)", + "output": "Immune Cell Function (Cellular Assay)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Edinburgh Postnatal Depression Scale (EPDS) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: tibia (Body Part, Organ, or Organ Component)\tCDISC Questionnaire EPDS Test Name Terminology (CDISC Questionnaire Terminology)\tregulation of epidermis development (regulation of developmental process)\tGlottic Cancer Clinical TNM Finding v7 (Finding)\tBAG4 wt Allele (Gene or Genome)", + "output": "CDISC Questionnaire EPDS Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: transmembrane transporter complex described as a protein complex that enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in).\nConcepts: calcium:proton antiporter complex location (Cell Component)\t6MWT - Distance at 4 Minutes (6MWT Functional Test Question)\tmicrovillus membrane (Cell Component)\tBiochemistry and Cellular Biology (Cytology)\tUniformity of Dosage Units (quality assurance)", + "output": "calcium:proton antiporter complex location (Cell Component)" + }, + { + "input": "Definition: Gene or Genome described as human CD163 wild-type allele is located in the vicinity of 12p13.3 and is approximately 33 kb in length. This allele, which encodes scavenger receptor cysteine-rich type 1 protein M130, is involved in the clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages.\nConcepts: CD163 Molecule wt Allele (Gene or Genome)\tPELLET, IMPLANTABLE (Oral Pellet)\t3p14.2 (Cell Component)\torganonitrogen compound metabolism (nitrogen compound metabolic process)\tHow Much Distress Weight Loss (Intellectual Product)", + "output": "CD163 Molecule wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Paramyxoviridae Infections described as infections with viruses of the family PARAMYXOVIRIDAE. This includes MORBILLIVIRUS INFECTIONS; RESPIROVIRUS INFECTIONS; PNEUMOVIRUS INFECTIONS; HENIPAVIRUS INFECTIONS; AVULAVIRUS INFECTIONS; and RUBULAVIRUS INFECTIONS.\nConcepts: Paramyxoviridae Infection (Disease or Syndrome)\tParaimmunoglobulinemia (Plasma cell dyscrasia)\tCarcinosarcoma, NOS (Malignant Neoplasms)\tPineal hyperplasia, insulin-resistant diabetes mellitus and somatic abnormalities (Diabetes mellitus associated with genetic syndrome)\tCSS0819A (C-SSRS Children's Since Last Visit Questionnaire Question)", + "output": "Paramyxoviridae Infection (Disease or Syndrome)" + }, + { + "input": "Definition: Adrenal Cortical Carcinoma TNM Finding v8 described as a pathologic finding about one or more characteristics of adrenal cortical carcinoma, following the rules of the TNM AJCC v8 classification system.\nConcepts: Adrenal Cortical Carcinoma Pathologic TNM Finding v8 (Adrenal Cortical Carcinoma TNM Finding v8)\tXenophagy (Cell Function)\tInfantile sensorineural hearing loss (Finding)\tfacial nucleus development (neural nucleus development)\tAnogenital warts (Lesion of skin and/or skin-associated mucous membrane)", + "output": "Adrenal Cortical Carcinoma Pathologic TNM Finding v8 (Adrenal Cortical Carcinoma TNM Finding v8)" + }, + { + "input": "Definition: Gene or Genome described as human PVRIG wild-type allele is located in the vicinity of 7q22.1 and is approximately 5 kb in length. This allele, which encodes transmembrane protein PVRIG, may be involved in immune checkpoint signaling.\nConcepts: Grade 3 Hydrocephalus (Finding)\tChromosome 7 Open Reading Frame 15 Gene (Gene or Genome)\tHealth system guidance (Health System Mediation)\tnegative regulation of hepatic stellate cell migration (Cell Function)\tIntegral Membrane Protein GPR180, human (G-Protein-Coupled Receptors)", + "output": "Chromosome 7 Open Reading Frame 15 Gene (Gene or Genome)" + }, + { + "input": "Definition: Hematologic Tests described as a measurement of the hemosiderin complex in a biological specimen.\nConcepts: HMOSIDRN (Laboratory Procedure)\tMissouri (Midwestern United States)\tintermediate filament polymerization or depolymerization (Cell Function)\tBEBQ0110 (BEBQ Concurrent Version Questionnaire Question)\tShakey voice (Voice)", + "output": "HMOSIDRN (Laboratory Procedure)" + }, + { + "input": "Definition: Gene or Genome described as human NID1 wild-type allele is located in the vicinity of 1q43 and is approximately 98 kb in length. This allele, which encodes nidogen-1 protein, is involved in the maintenance of the structure of the basement membrane.\nConcepts: NID1 wt Allele (NID1 gene)\tFatty Acid cis 22:1 n-9 (Organic Chemical)\tcis-Golgi cisterna membrane (Cell Component)\tmeiotic centromeric cohesion protection (maintenance of meiotic sister chromatid cohesion, centromeric)\tisomerase activity (enzyme activity)", + "output": "NID1 wt Allele (NID1 gene)" + }, + { + "input": "Definition: divalent inorganic cation homeostasis described as any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell.\nConcepts: nickel cation homeostasis (divalent inorganic cation homeostasis)\tHistamine Receptor (Neurotransmitter Receptor)\t(+-)Cyclobut-G (Nucleic Acid, Nucleoside, or Nucleotide)\tStage IIA (Enneking Staging System)\tmembrane stack (Endoplasmic Reticulum)", + "output": "nickel cation homeostasis (divalent inorganic cation homeostasis)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.\nConcepts: BBI503 (Pharmacologic Substance)\tAlbumin-Bound Paclitaxel (Taxane derivative)\tpachytene (meiosis I cell cycle phase)\tFOP - Fibrodys oss progressiva (Hereditary Diseases)\tup regulation of glucocorticoid metabolic process (positive regulation of steroid metabolic process)", + "output": "up regulation of glucocorticoid metabolic process (positive regulation of steroid metabolic process)" + }, + { + "input": "Definition: Osteopathic procedures described as the therapeutic application of manually guided forces by an osteopath (non-physician) to improve physiological function and homoeostasis that has been altered by somatic dysfunction.\nConcepts: Vena Caval Clips (Tissue clip)\tOSTEOPATHIC MANIPULATIONS (Osteopathic procedures)\tGrade 4 Esophageal Obstruction, CTCAE (Esophageal Obstruction, CTCAE 5)\tFamily Peptococcaceae (Clostridiales)\tVillus intestinalis (Body Part, Organ, or Organ Component)", + "output": "OSTEOPATHIC MANIPULATIONS (Osteopathic procedures)" + }, + { + "input": "Definition: something described as measurement of the dimensions of the head.\nConcepts: head measurements (Measurement)\tanthropometry (Research Activity)\tSet of pancreatic lymph nodes (Lymph node group)\tElectrosleep Treatment (Physical Treatment Methods)\tophthal.proc ref cde nc (Health Care Activity)", + "output": "head measurements (Measurement)" + }, + { + "input": "Definition: Cyclic Peptides described as a semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria.\nConcepts: Alumina silicata / kaolin (Pharmacologic Substance)\tHSGAG Mimetic M402 (Antineoplastic Agents)\tDaptomycin product (Cyclic Peptides)\tAbutment tooth condition severely compromised, 4 or more sextants (Abutment tooth condition finding)\tGreat Dane (Mammal)", + "output": "Daptomycin product (Cyclic Peptides)" + }, + { + "input": "Definition: Quantitative Concept described as liters per minute (flow rate), divided by milligrams per meter squared per day (daily dose normalized by surface area) or milliliters per minute (flow rate), divided by micrograms per meter squared per day (daily dose normalized by surface area).\nConcepts: (l/min)/(mg/m2/d) (Quantitative Concept)\tLipogenesis (organic substance biosynthetic process)\tBETA-THALASSEMIA, DOMINANT (Disease or Syndrome)\tLEC0104C (Intellectual Product)\tHemodialysis Catheter-Associated Bacteremia (Infection of hemodialysis catheter)", + "output": "(l/min)/(mg/m2/d) (Quantitative Concept)" + }, + { + "input": "Definition: something described as the membrane potentials across the SYNAPTIC MEMBRANES of the target cells of the NEUROTRANSMISSION pathway.\nConcepts: Postsynaptic Potential (Organ or Tissue Function)\tintegral to MOM (integral component of cell outer membrane)\tcomplies with (Functional Concept)\tBrilacidin Oral Rinse (Biological Response Modifiers)\tPediatric Ovarian Teratoma (Ovarian Teratoma)", + "output": "Postsynaptic Potential (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as brief Psychiatric Rating Scale 1988 Version - Uncooperativeness.\nConcepts: Cancer Cell Growth Regulation (Neoplastic Process)\tBPRS01-Uncooperativeness (BPRS 1988 Version Clinical Classification Question)\ttoluene oxidation via 3-hydroxytoluene (toluene oxidation)\tCAST (Intellectual Product)\tDanbolt-Close syndrome (Skin Abnormalities)", + "output": "BPRS01-Uncooperativeness (BPRS 1988 Version Clinical Classification Question)" + }, + { + "input": "Definition: Medical Device described as an orthopedic manual surgical instrument is a nonpowered hand-held device intended for medical purposes to manipulate tissue, or for use with other devices in orthopedic surgery. This generic type of device includes the cerclage applier, awl, bender, drill brace, broach, burr, corkscrew, countersink, pin crimper, wire cutter, prosthesis driver, extractor, file, fork, needle holder, impactor, bending or contouring instrument, compression instrument, passer, socket positioner, probe, femoral neck punch, socket pusher, reamer, rongeur, scissors, screwdriver, bone skid, staple driver, bone screw starter, surgical stripper, tamp, bone tap, trephine, wire twister, and wrench.\nConcepts: Carcinomas, Nasopharyngeal (Primary malignant neoplasm of pharynx)\tPQL1315 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)\tCDISC ADAS-Cog - Delayed Word Recall Summary Score (Intellectual Product)\tSKID, BONE (Medical Device)\t4: 186122364-186051899 (Chromosome 4 Physical Location)", + "output": "SKID, BONE (Medical Device)" + }, + { + "input": "Definition: Vitamin B Complex Member described as an aminobenzoic acid isomer that combines with pteridine and GLUTAMIC ACID to form FOLIC ACID. The fact that 4-aminobenzoic acid absorbs light throughout the UVB range has also resulted in its use as an ingredient in SUNSCREENS.\nConcepts: ng/mL/(mg/kg) (Quantitative Concept)\tLocally Advanced Unresectable Sarcoma (Locally Advanced Sarcoma)\tMLL-ELL Fusion Gene (Gene or Genome)\tAMINOBENZOIC ACID (Salicylates)\tbrain tumor, childhood grade IV astrocytoma (Neoplastic Process)", + "output": "AMINOBENZOIC ACID (Salicylates)" + }, + { + "input": "Definition: HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Primary Tumor TNM Finding v8 described as HPV-mediated (p16-positive) oropharyngeal cancer with tumor larger than 4 cm in greatest dimension or extension to lingual surface of epiglottis.\nConcepts: microtubule anchoring at centrosome (Cell Function)\tTAP2 (ATP-Binding Cassette Transporters)\tHPV-Mediated (p16-Positive) Oropharyngeal Cancer pT3 TNM Finding v8 (HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Primary Tumor TNM Finding v8)\tMEGALOBLASTIC ANEMIA (Anemia related to disturbed DNA synthesis)\tcap (Package Type)", + "output": "HPV-Mediated (p16-Positive) Oropharyngeal Cancer pT3 TNM Finding v8 (HPV-Mediated (p16-Positive) Oropharyngeal Cancer Pathologic Primary Tumor TNM Finding v8)" + }, + { + "input": "Definition: Bladder Cancer Pathologic Distant Metastasis TNM Finding v8 described as bladder cancer with distant metastasis.\nConcepts: Bladder Cancer pM1 TNM Finding v8 (Finding)\tTumor-Associated Antigen (Biomarkers, Tumor)\tbryostatin 1 (Pharmacologic Substance)\tswells (Finding)\tTraction Units, Static, Chair (Traction Units, Static)", + "output": "Bladder Cancer pM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as a water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-shistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated form the plant Artemisia annua. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C73005\" active clinical trials using this agent.\nConcepts: Death Diagnosis Original Result (Finding)\tMedication Persistence (Quantitative Concept)\tProgressive muscular dystrophy (Atrophy, Disuse)\tBronchiectasis, NOS (Lung)\tArtesunate product (A [Preparations])", + "output": "Artesunate product (A [Preparations])" + }, + { + "input": "Definition: Cell described as these cells produce SECRETIN and are found in the MUCOSA of upper SMALL INTESTINE and PYLORIC ANTRUM in mammals. Secretin also has been found in cells in the BRAIN and other tissues.\nConcepts: Radiation Overdose (Overdoses NEC)\tPOPLITEAL ARTERY ENTRAPMENT SYNDROME (Injury of systemic artery)\tSecretin Cells of Gut (Cell)\tanti-Nectin-4 monoclonal antibody-drug conjugate AGS-22M6E (Pharmacologic Substance)\tPUL01-Distal Wrist/Hand Dimension (PUL 1.2 Functional Test Question)", + "output": "Secretin Cells of Gut (Cell)" + }, + { + "input": "Definition: mental health counseling described as teaching clients in a group setting memory recall techniques to improve their abilities to remember. Service is billed in 60-minute increments per client.\nConcepts: SIQ01-Wished I Had the Nerve Kill Myself (SIQ Questionnaire Question)\tRibonucleosides (Nucleosides)\tShort-Acting Myeloid Growth Factor (Recombinant Hematopoietic Growth Factor)\tNasal Cavity and Ethmoid Sinus Cancer pT2 TNM Finding v6 and v7 (Nasal Cavity and Ethmoid Sinus Cancer Pathologic Primary Tumor TNM Finding v6)\tMemory education assistance group each 60 minutes (Therapeutic or Preventive Procedure)", + "output": "Memory education assistance group each 60 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: negative regulation of cell differentiation involved in embryonic placenta development described as the transforming growth factor signaling process that decreases the rate, frequency, or extent of trophoblast stem cells differentiating into the more mature cells of the trophoblast.\nConcepts: keto acid metabolic process (organic acid metabolic process)\tnegative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway (negative regulation of cell differentiation involved in embryonic placenta development)\tPeritoneal Surface Disease (Disease or Syndrome)\tPlant Oils (Dietary Oils)\tIodine Staining Method (Laboratory Procedure)", + "output": "negative regulation of trophoblast cell differentiation by transforming growth factor beta signaling pathway (negative regulation of cell differentiation involved in embryonic placenta development)" + }, + { + "input": "Definition: Hemorrhagic Disorders described as hemorrhage originating at any site located within the gastrointestinal tract.\nConcepts: GASTROINTESTINAL BLEEDING (gastrointestinal circulation disorder)\t2'-5'-RNA ligase activity (Molecular Function)\tGlottic Cancer Pathologic Primary Tumor TNM Finding v6 (Glottic Cancer Pathologic TNM Finding v6)\tshort descending thin limb development (Organ or Tissue Function)\tmagnesium ion transmembrane transporter activity (metal ion transmembrane transporter activity)", + "output": "GASTROINTESTINAL BLEEDING (gastrointestinal circulation disorder)" + }, + { + "input": "Definition: Anesthesia/Respiratory Equipment and Supplies described as devices that provide feedback regarding the rate of chest compressions during cardiopulmonary resuscitation (CPR) or CPR training. The feedback can be visual or auditory or both.\nConcepts: Pacers, Counting, CPR (Anesthesia/Respiratory Equipment and Supplies)\tGrade 2 Pancreatic Enzymes Decreased, CTCAE (Finding)\tEmbolisation of hepatic artery using selective internal radiation therapy (Embolization of hepatic artery)\thiv envelope protein gp120 (env Gene Products, Human Immunodeficiency Virus)\tCDISC Clinical Classification Reynolds CVD 10-Year Risk Score Test Name Terminology (Intellectual Product)", + "output": "Pacers, Counting, CPR (Anesthesia/Respiratory Equipment and Supplies)" + }, + { + "input": "Definition: Protein phosphatase described as an enzyme that deactivates glycogen phosphorylase a by releasing inorganic phosphate and phosphorylase b, the inactive form. EC 3.1.3.17.\nConcepts: Malignant Major Salivary Gland Neoplasm (Disorder of digestive organ)\tIVD Test Reagent/Kits, Cytology/Histology, Antisera, Polyvalent (Medical Device)\tBPI107 (BPI Questionnaire Question)\tPhosphatase, Phosphorylase (Hydrolase)\tnorepinephrine-epinephrine vasodilation during blood pressure regulation (Vasodilation)", + "output": "Phosphatase, Phosphorylase (Hydrolase)" + }, + { + "input": "Definition: unclassified Enterovirus described as any viral organism that can be assigned to the species Echovirus.\nConcepts: Sentinel node biopsy followed by surgical evaluation of axilla (Diagnostic Procedure)\tSerine acetyltransferase (Amino Acid, Peptide, or Protein)\tHUMAN ECHOVIRUS (Echovirus+Coxsackievirus)\tCiclopirox (Skin antifungal agent, NOS)\tDepressants, CNS (neurological agents)", + "output": "HUMAN ECHOVIRUS (Echovirus+Coxsackievirus)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Visual Functioning Questionnaire 25-Interviewer Administered Format Version 2000 (VFQ25-Interviewer Administered Format) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: Lagopthalmos (Abnormal eyelid morphology)\tQS-VFQ25-Interviewer Administered Format TEST (CDISC Questionnaire Terminology)\tN(1)-Pyridylsulfanilamide (Sulfonamide Anti-Infective Agents)\tpyridoxal phosphate catabolic process (Molecular Function)\tMatrix-Assisted Laser Desorption Ionization Time-of-Flight MS (Chemistry analyses NEC)", + "output": "QS-VFQ25-Interviewer Administered Format TEST (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as a subjective response indicating something was worse than expected.\nConcepts: Localized Carcinoma (Localized Malignant Neoplasm)\tSteroid hormones (Biochemical analyte functional group)\tWorse than I expected (Intellectual Product)\tDuplicated thumb (Abnormality of thumb phalanx)\tmale sex chromosome (X & Y chromosome)", + "output": "Worse than I expected (Intellectual Product)" + }, + { + "input": "Definition: something described as the perception of sudden or brief bursts (flashes) of light.\nConcepts: Triggered by sleep deprivation (Triggered by)\tFlashing lights (Sign or Symptom)\tWD4S9 (Intellectual Product)\taxon microtubule fascicle (Microtubule Bundle)\tInfectious disease prevention / control (Procedure with a clinical finding focus)", + "output": "Flashing lights (Sign or Symptom)" + }, + { + "input": "Definition: something described as inhibition of Cell Proliferation involves intercellular, cellular, and subcellular mechanisms that inhibit or block the induction, promotion, maintenance, or completion cell division.\nConcepts: PQL0825 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)\tFAC02914 (FBRSI Questionnaire Question)\tCisplatin-Gemcitabine-Paclitaxel Regimen (Regimen Used to Treat Non-Small Cell Lung Carcinoma)\tdown regulation of cell proliferation (regulation of cell population proliferation)\tPattern 1 (Classification)", + "output": "down regulation of cell proliferation (regulation of cell population proliferation)" + }, + { + "input": "Definition: Qualitative Concept described as specifies the degree or extent of the consequence suffered by the subject. EXAMPLE(S): resulted in death, required hospitalization, was life threatening OTHER NAME(S): NOTE(S): While often not reported as a separate observation, seriousness codes are technically the result of assessing the subject and the adverse event they are experiencing. The association to the AdverseEvent should theoretically be derivable via the following path: AdverseEventSeriousness > PerformedObservation [assess seriousness] > AssessedResultRelationship > AdverseEvent. However, since this information is often not available, AdverseEventSeriousness has been modeled as both a subclass of PerformedClinicalInterpretation and as having an association directly to the AdverseEvent class.\nConcepts: glycerol-3-phosphate dehydrogenase complex location (Cell Component)\tMaternal Weight Gain in Pregnancy (Weight Gain)\tDeletn short arm chromosome 5 (Syndrome)\tAESER (Adverse Event Characteristics)\tSalaam Attacks (Convulsive Seizures)", + "output": "AESER (Adverse Event Characteristics)" + }, + { + "input": "Definition: Organic Chemical described as a synthetic organophosphate acetylcholinesterase inhibitor that is used as a pesticide. It is characterized as a colorless to pale yellow or light brown liquid with a skunk-like odor, and exposure occurs by inhalation, ingestion, or contact.\nConcepts: neurofilaments (Intermediate Filaments)\tregulation of toxin transport (regulation of transport)\tNUP98/NSD1 Fusion Protein (Amino Acid, Peptide, or Protein)\tPhorate (Organothiophosphate pesticides)\tAdverse Event Related to Commutability (Functional Concept)", + "output": "Phorate (Organothiophosphate pesticides)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the 4 Stair Ascend functional test.\nConcepts: phytochromobilin biosynthesis (Molecular Function)\t4 Stair Ascend Functional Test Question (Clinical or Research Assessment Question)\thN1 c.7396 7397ins5 (Cell or Molecular Dysfunction)\tproton-transporting V-type ATPase, V0 domain (proton-transporting two-sector ATPase complex, proton-transporting domain)\tEnterocloster bolteae (Bacterium)", + "output": "4 Stair Ascend Functional Test Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of distal bile duct cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for distal bile duct cancer.\nConcepts: Stimulators, Electrical, Aversion Conditioning (Medical Device)\tDistal Bile Duct Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)\tpremRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tFAMILY MUSCIDAE (Muscoidea)\tPedsQL Neuromuscular Module Acute Version 3.0 Young Child Report - Hard to Go Places With Equipment (Intellectual Product)", + "output": "Distal Bile Duct Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Immunologic Factor described as a peptide vaccine composed of IO103, a peptide vaccine derived from the tumor-associated antigen (TAA) programmed cell death-1 ligand 1 (PD-L1), IO102, the 21-mer peptide vaccine derived from the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO), and the immunoadjuvant montanide ISA-51, with potential immunomodulating and antineoplastic activities. Vaccination with the PD-L1/IDO peptide vaccine may activate the immune system to induce an immune response against PD-L1 and IDO-expressing cells. This may increase and restore the proliferation and activation of various immune cells, including cytotoxic T lymphocytes (CTLs), and may eradicate PD-L1 and IDO-expressing tumor cells through a CTL-mediated immune response. PD-L1 is overexpressed on many human cancer cell types. PD-L1 binding to its cognate receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) on T-cells suppresses the immune system and results in increased immune evasion and decreased CTL activation. IDO, a cytosolic enzyme responsible for tryptophan catabolism and conversion of tryptophan into kynurenine, is overexpressed by a variety of tumor cell types and antigen presenting cells (APCs) and plays an important role in immunosuppression mainly through suppression of CTL activation; tryptophan depletion inhibits T-lymphocyte proliferation and activation, and suppresses the immune system. Montanide ISA-51, also known as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant that non-specifically stimulates cell-mediated immune responses to antigens.\nConcepts: BIFIDOBACTERIUM PSEUDOCATENULATUM (Bifidobacterium)\tTreponema Schaudinn 1905 emend Abt et al. 2013 (BACTERIA AND RICKETTSIAE)\tsuperficial portion of medial part of basal amygdaloid nucleus (basolateral nucleus of the amygdala)\tMAOA (Hypnotics)\tPD-L1/IDO Peptide Vaccine (Amino Acid, Peptide, or Protein)", + "output": "PD-L1/IDO Peptide Vaccine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Thyroiditis described as inflammatory disease of the THYROID GLAND due to autoimmune responses leading to lymphocytic infiltration of the gland. It is characterized by the presence of circulating thyroid antigen-specific T-CELLS and thyroid AUTOANTIBODIES. The clinical signs can range from HYPOTHYROIDISM to THYROTOXICOSIS depending on the type of autoimmune thyroiditis.\nConcepts: Oculoplethysmographs (Device associated with transducers)\tthyroiditis; autoimmune (Acute and chronic thyroiditis)\tEC 3.1.3.16 (Enzyme)\tFETLFNUM (Quantitative Concept)\tPatch (Package Type)", + "output": "thyroiditis; autoimmune (Acute and chronic thyroiditis)" + }, + { + "input": "Definition: Phenomenon or Process described as the weak attraction between two or more chemical entities that is caused by the polarization of adjacent atoms or molecules.\nConcepts: dense fibrillar component (cellular anatomical entity)\tglutaminyl cyclase activity (Molecular Function)\tOval vertebral bodies (Finding)\tBehavioral Control (Behavioral Disciplines and Activities)\tvan der Waals Attraction (Biophysical Processes)", + "output": "van der Waals Attraction (Biophysical Processes)" + }, + { + "input": "Definition: Research Activity described as a method of euthanasia whereby a subject is anesthetized and the spinal column is dislocated from the skull and brain.\nConcepts: Anesthesia and Cervical Dislocation Euthanasia (Research Activity)\tlow affinity sodium:dicarboxylate symporter activity (sodium:dicarboxylate symporter activity)\tCreatine Kinase, Mitochondrial (Mitochondrial Proteins)\tc-Raf Gene Amplification (Gene Amplification Abnormality)\tAUDIT - How Many Alcohol Drinks on a Typical Day (AUDIT Questionnaire Question)", + "output": "Anesthesia and Cervical Dislocation Euthanasia (Research Activity)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a steroid hormone.\nConcepts: Facies superficiales (Anatomical Structure)\tmL/cage/wk (Quantitative Concept)\tTeat Route of Administration (Functional Concept)\tsteroid hormone binding (hormone binding)\tMajor Salivary Gland Cancer pN3b TNM Finding v8 (Major Salivary Gland Cancer pN3 TNM Finding v8)", + "output": "steroid hormone binding (hormone binding)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).\nConcepts: Personal hygiene (Comfortable death status)\tprotein self-association (Protein Binding)\tcollagen biosynthetic process (Anabolism)\tDNA condensation (Cell Physiological Processes)\tenvironmental radiation (Environmental Pollution)", + "output": "collagen biosynthetic process (Anabolism)" + }, + { + "input": "Definition: Hereditary degenerative disease of central nervous system described as an abnormal accumulation of cerebrospinal fluid within the ventricles of the brain that occurs as a consequence of impaired cerebrospinal fluid reabsorption by the arachnoid granulations.\nConcepts: HYDROCEPHALUS, COMMUNICATING (Disease or Syndrome)\tCold-Shock Response (Organism Function)\tCHSF1-Live With Spouse or Signif Other (CHART-SF Interview Version Questionnaire Question)\tLabyrinth Fenestration (Inner ear and/or eustachian canal operations)\tImmune effector cell (Lymphocyte)", + "output": "HYDROCEPHALUS, COMMUNICATING (Disease or Syndrome)" + }, + { + "input": "Definition: Traditional Medicine described as the study of the actions and properties of medicinal agents, often derived from PLANTS, indigenous to populations or ETHNIC GROUPS.\nConcepts: protein localization to juxtaparanode region of axon (Cell Function)\tETHNOPHARMACOL (Traditional Medicine)\tHypercapnemia (Disorder of acid-base balance)\tSigma Metrics (Qualitative Concept)\tHIV-1 Antigen Measurement (Human immunodeficiency virus test)", + "output": "ETHNOPHARMACOL (Traditional Medicine)" + }, + { + "input": "Definition: Study Site Status described as an indication that a study site has closed down and is no longer participating in a study.\nConcepts: FIGO Stage II Carcinoma of Cervix (stage, cervical cancer)\tPlasmacytoid Dendritic Cells (Myeloid Cells)\tNeisseria meningitidis, Serogroup Y (Neisseria meningitidis)\tCordonnier Sepsis Syndrome Requiring Transfer to Intensive Care Unit (Cordonnier Nonmicrobially-Defined Infection)\tSite Dissolved (Qualitative Concept)", + "output": "Site Dissolved (Qualitative Concept)" + }, + { + "input": "Definition: UDP-glycosyltransferase activity described as catalysis of the reaction: UDP-D-galacturonate + 1,4-alpha-D-galacturonosyl(n) = 1,4-alpha-D-galacturonosyl(n+1) + UDP.\nConcepts: Indians, Central American (Canadian and Latin American Indian race)\tplastic bottles (Medical Device)\ttesticle microlithiasis (Testicular Diseases)\turidine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity (Molecular Function)\tFACT-LEU Version 4 - Worry My Condition Will Get Worse (FACT-LEU Version 4 Questionnaire Question)", + "output": "uridine diphosphogalacturonate-polygalacturonate alpha-galacturonosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: CPTAC Responses described as a response that routine cytogenetic testing was completed.\nConcepts: Myelin Proteolipid Protein (Structural protein)\tLEC01-Captivity: Happened (Intellectual Product)\tRoutine Cytogenetics Were Completed (Finding)\tCheckpoint (cellular process)\tSalicylicum acidum / salicylic acid (Organic Chemical)", + "output": "Routine Cytogenetics Were Completed (Finding)" + }, + { + "input": "Definition: Medical Device described as non-medical products used to aid in ending a SMOKING habit.\nConcepts: positive regulation of protein polyglycylation (Molecular Function)\tWater, Heavy (water)\tSmoking Cessation Products (Medical Device)\tacylpyruvate hydrolase activity (Molecular Function)\tStage III Primary Peritoneal Cancer AJCC v7 (Neoplastic Process)", + "output": "Smoking Cessation Products (Medical Device)" + }, + { + "input": "Definition: Finding described as problem associated with the increased rate of change in temperature, pressure, or other variables as a function of distance, time, etc.\nConcepts: AVL0212 (AVLT-REY Functional Test Question)\tStructure of crista galli (Crest)\tGradient Increase (Improper Flow or Infusion)\tAnti-hepcidin Monoclonal Antibody LY2787106 (Immunologic Factor)\tchemical tests (Laboratory Class)", + "output": "Gradient Increase (Improper Flow or Infusion)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: My child does not have the equipment he or she needs.\nConcepts: vascular headache (Headache Disorders, Secondary)\tsecond messenger-mediated signalling (Molecular Function)\tIntention Tremor (Tremor)\tAutologous Anti-BCMA-CAR-4-1BB-CD3zeta-expressing Memory T-Cells bb21217 (Antineoplastic Immune Cell)\tPQL1325 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)", + "output": "PQL1325 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)" + }, + { + "input": "Definition: Chromosome 9 Physical Location described as physical location of CREB3_Gene\nConcepts: transitional cell cancer bladder (Neoplastic Process)\tStereotactic Systems, Image-Guided, Surgical (Stereotactic Systems)\tLung Mucinous Adenocarcinoma In Situ (Lung Adenocarcinoma In Situ)\tdeficiency riboflavin (Vitamin Deficiency)\t9: 35722317-35727005 (Chromosome 9 Physical Location)", + "output": "9: 35722317-35727005 (Chromosome 9 Physical Location)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify Toxoplasma gondii, a species of obligate intracellular coccidian protozoa parasite, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target parasite. These parasites may cause toxoplasmosis, a mild and self-limited infection, but extensive damage (e.g., to the brain, eyes, cardiac muscle) may occur, mostly in immunocompromised patients or through transplacental transmission to a fetus. The parasites are usually transmitted via feces of cats or through tissue cysts in infected meat.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Toxoplasma gondii, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Toxoplasma Species)\tSubstantia medullaris annectens (Structure of white matter of occipital lobe)\tmuscles tumors (Soft Tissue Neoplasms)\tSF-36 v2.0 Acute - Question 4d (SF36 v2 0 Acute Questionnaire Question)\tfatty alcohol metabolic process (alcohol metabolism)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Toxoplasma gondii, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Toxoplasma Species)" + }, + { + "input": "Definition: Record Link Identifier described as a sequence of characters used as a linkage between related collected exposure records.\nConcepts: Liver Cancer Pathologic Distant Metastasis TNM Finding v6 (Finding)\tregulation of microRNA metabolic process (regulation of RNA metabolic process)\tprotein kinase, AMP-activated, alpha 2 catalytic subunit, human (Protein-Serine-Threonine Kinases)\tExposure as Collected Link Identifier (Record Link Identifier)\tRadial subluxation (Subluxation of joint of upper limb)", + "output": "Exposure as Collected Link Identifier (Record Link Identifier)" + }, + { + "input": "Definition: IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Telephone Format - During the last 7 days, how much time did you usually spend sitting on a weekday?: Hours per weekday.\nConcepts: Volume of Distribution of Fraction Dose Observed Normalized by Surface Area (Observed Volume of Distribution of Absorbed Fraction)\tIPA0107A (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tPhosphatidylinositol 3-Kinase, Regulatory Subunit, 85-kD, Alpha Gene (PIK3R1 gene)\tGrade 2 Neonatal Respiratory Insufficiency, Adverse Event (Neonatal Respiratory Insufficiency, Adverse Event)\thydroxyzine hydrochloride (Other antiemetics in ATC)", + "output": "IPA0107A (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)" + }, + { + "input": "Definition: transferase activity, transferring acyl groups other than amino-acyl groups described as catalysis of the reaction: 4-coumaryl-CoA + H+ + an anthocyanidin-3-O-beta-D-glucoside = coenzyme A + H+ + an anthocyanidin-3-O-[6-O-(hydroxycinnamoyl)-beta-D-glucoside].\nConcepts: Mucoepidermoid carcinoma of submandibular gland (Submandibular Gland Neoplasms)\tanthocyanidin 3-O-glucoside 6''-O-acyltransferase activity (Molecular Function)\tFacial diplegia (MUSCLE SOFT, TISSUE)\tHORTON SYNDROME (Cluster headaches and other trigeminal autonomic cephalgias)\tPD-L1 Inhibitor INCB086550 (Pharmacologic Substance)", + "output": "anthocyanidin 3-O-glucoside 6''-O-acyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the perforin 1 (pore forming protein) (PRF1) gene, located at chromosome 10q22, which encodes for a protein that can create transmembrane tubules and is a component of cytolytic granules that can cause apoptosis in a variety of target cells. This protein is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytotoxicity. This genetic mutation has been identified in patients with familial hemophagocytic lymphohistiocytosis type 2.\nConcepts: Extra-Adrenal Pheochromocytomas (Neoplastic Process)\turinary bladder smooth muscle contraction (Organ or Tissue Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PRF1 (Medical Device)\tpartial monosomy 9q (Mental Retardation)\tRespirable Tridymite (Hazardous or Poisonous Substance)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, PRF1 (Medical Device)" + }, + { + "input": "Definition: something described as a collection of specialized words or terms with their meanings.\nConcepts: Elasmobranchius (Fish)\tFEV6PP (Pulmonary function tests)\tPressure, Aortic Pulse (Organism Function)\tKetorolac trometamol [eye] (Heteroaryl acetic acid)\tGlossaries (Document type)", + "output": "Glossaries (Document type)" + }, + { + "input": "Definition: DISEASES OF THE ENDOCRINE PANCREAS INCLUDING DIABETES described as a rare association of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness.\nConcepts: DIDMOAD (Multiple congenital anomalies)\tenvenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism (envenomation resulting in modulation of receptor activity in other organism)\tDrug Used at Visit (Other Finding)\tSenior Scientist (Research Personnel)\tastaxanthin catabolism (drug catabolic process)", + "output": "DIDMOAD (Multiple congenital anomalies)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any regimen that can be used for the treatment of plasma cell neoplasm.\nConcepts: Benzenepropanoic acid, 3-amino-alpha-ethyl-2,4,6-triiodo- (benzene)\tFibrillary gliosis (Pathologic Function)\tmitochondrial NAD transmembrane transport (NAD transmembrane transport)\tIVD Test Reagent/Kits, Serology, Parasite, Babesia Species, Antibody (IVD Test Reagent/Kits, Serology, Parasite)\tRegimen Used to Treat Plasma Cell Neoplasm (Chemo/immuno/hormone Therapy Regimen)", + "output": "Regimen Used to Treat Plasma Cell Neoplasm (Chemo/immuno/hormone Therapy Regimen)" + }, + { + "input": "Definition: developmental process involved in reproduction described as a process required for sperm to reach fertilization competence. Sperm undergo an incompletely understood series of morphological and molecular maturational processes, termed capacitation, involving, among other processes, protein tyrosine phosphorylation and increased intracellular calcium.\nConcepts: Spermatozoa Capacitation (Cell Function)\tHKT 288 (Antineoplastic Antibody-Drug Conjugate)\tDentatorubropallidoluysian degeneration (Cerebellar Ataxia)\tFlowmeters, Blood, Radioactive Tracer, Cerebral Xenon Clearance (Medical Device)\tCancer Center Planning Grant (Governmental or Regulatory Activity)", + "output": "Spermatozoa Capacitation (Cell Function)" + }, + { + "input": "Definition: epithelial cell-cell adhesion described as the attachment of a melanocyte to another cell via adhesion molecules.\nConcepts: melanocyte adhesion (Cell Function)\tAiredale (Dog family)\tLeiomyosarcoma of Small Intestine (sarcoma of small intestine)\tShared Pathology Informatics Network (Consortium or Network)\tFlowmeters, Gas, Respiratory, Medical-Air (Medical Device)", + "output": "melanocyte adhesion (Cell Function)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides.\nConcepts: CTP degradation (CTP metabolic process)\tGastrointestinal System (Topography Axis)\tExtensor carpi ulnaris muscle (Skeletal muscle structure of upper limb)\tF-9775B biosynthetic process (phenol-containing compound biosynthetic process)\tarabinose metabolism (Molecular Function)", + "output": "arabinose metabolism (Molecular Function)" + }, + { + "input": "Definition: Medical Dictionary for Regulatory Activities Terminology (MedDRA), Russian Edition described as an abnormal mass of tissue that results when cells divide more than they should or do not die when they should. Neoplasms may be benign (not cancer), or malignant (cancer).\nConcepts: UHDR1-Total Functional Capacity Score (UHDRS 1999 Version Clinical Classification Question)\ttumors (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Russian Edition)\tPulmono- (Menu of Other Findings: Systems Review)\tgas vesicle wall (Cell Component)\t4-Chloro-2-methylaniline (Organic Chemical)", + "output": "tumors (Medical Dictionary for Regulatory Activities Terminology (MedDRA), Russian Edition)" + }, + { + "input": "Definition: Hematopoietic stem cells described as very large BONE MARROW CELLS which release mature BLOOD PLATELETS.\nConcepts: Crisscross Hearts (Congenital heart disease)\tStage IVA Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8 (Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage)\tfractured finger (Fracture)\tmegakaryocytes (Platelet precursor)\tBladder Cancer pN2 TNM Finding v6 (Finding)", + "output": "megakaryocytes (Platelet precursor)" + }, + { + "input": "Definition: Finding described as a finding or observation that is made during surgery.\nConcepts: DKFATS (CDISC SDTM Terminology)\tNuclear Matrix Proteins (Nuclear Proteins)\tOBTUNDATION (Neurological observations)\tInternal notch of the femoral head (Finding)\tSurgical Finding (Finding)", + "output": "Surgical Finding (Finding)" + }, + { + "input": "Definition: something described as the Rey Auditory Verbal Learning TEST (AVLT-REY) The number of List A intrusions while recalling from a trial.\nConcepts: MET Codon 1010 Splice Mutation (Cell or Molecular Dysfunction)\tAVLT-REY - List A Intrusions (AVLT-REY Functional Test Question)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Measles (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus)\tPeriocular capillary hemangioma (Strawberry nevus of skin)\tBody, Spindle Pole (Spindle Poles)", + "output": "AVLT-REY - List A Intrusions (AVLT-REY Functional Test Question)" + }, + { + "input": "Definition: Biologically Active Substance described as mitochondrial brown fat uncoupling protein 1 (307 aa, ~33 kDa) is encoded by the human UCP1 gene. This protein plays a role in thermogenesis.\nConcepts: Breast Cancer cN2 TNM Finding v6 (Finding)\tabrus precatorius/carbs eye (Organic Chemical)\tMitochondrial Brown Fat Uncoupling Protein 1 (Biologically Active Substance)\tpositive regulation of cell-substrate junction organization (Cell Function)\tpallor (Site specific vascular disorders NEC)", + "output": "Mitochondrial Brown Fat Uncoupling Protein 1 (Biologically Active Substance)" + }, + { + "input": "Definition: Abnormal Bone Marrow Test Result described as a condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets. Myelosuppression is a side effect of some cancer treatments. When myelosuppression is severe, it is called myeloablation.\nConcepts: Tumor of Neuroepithelium (INTERNATIONAL CLASSIFICATION OF NEOPLASMS)\tThyroid Gland Hyperfunctioning Adenoma (Neoplastic Process)\tCurved bones of 4th toe (Abnormality of the phalanges of the 4th toe)\tMyelosuppression (Finding)\tCRDIGAAB (Immunologic Tests)", + "output": "Myelosuppression (Finding)" + }, + { + "input": "Definition: something described as binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule.\nConcepts: SPECCOND (CDISC SDTM Terminology)\tkinase activator activity (Molecular Function)\tBone marrow/stem cell transplantation (Bone Marrow: Repair)\tOPB-51602 (Pharmacologic Substance)\tOBSERVATIONAL (Research Activities)", + "output": "kinase activator activity (Molecular Function)" + }, + { + "input": "Definition: Enterobacteriaceae described as a genus of facultatively anaerobic, Gram negative, rod shaped bacterium in the phylum Proteobacteria and the family Enterobacteriaceae.\nConcepts: VEIN, MESENTERIC (Veins)\thistone acetyltransferase binding (enzyme binding)\tVariable Expression (Phenotype)\tFluorescent PARPi Binding Imaging Agent PARPi-FL (Medicinal product acting as imaging agent)\tTatumella species (Family Erwiniaceae)", + "output": "Tatumella species (Family Erwiniaceae)" + }, + { + "input": "Definition: Cell Component described as the actin cytoskeleton that is part of a dendritic spine.\nConcepts: Rhodomicrobium vannielii (Rhodomicrobium)\tSertoli Cell-Only Syndrome (congenital absence of genital organs)\tDisorder liver (Liver diseases)\tactin cytoskeleton of dendritic spine (Cell Component)\tTHPH7 (SERPINC1 gene)", + "output": "actin cytoskeleton of dendritic spine (Cell Component)" + }, + { + "input": "Definition: Medical Device described as upper-limb orthoses designed for external modification of the structural and/or functional characteristics of the elbow joint, providing immobilization and/or support. These orthoses are usually classified according to the function of the orthoses (e.g., immobilization, support, therapeutic, functional) and the physical characteristics (e.g., shape, consistency) and/or material used to make the orthosis (metal, plastics or a combination of these). Elbow upper-limb orthoses may consist of soft orthoses (e.g., a combination of cuffs, straps, and flexible mechanisms) that are intended to provide limited support and stabilization or semi-rigid orthoses that can provide a high degree or total immobilization of the elbow joint. Elbow upper-limb orthoses are intended mainly to provide motion control of the elbow movements, for complete immobilization of the joint, and to avoid pain after injuries or trauma. Dedicated elbow orthoses for immobilization, static and/or dynamic therapy, and for use during normal daily (i.e., functional) use of the elbow are available.\nConcepts: GCS0105H (Intellectual Product)\tPeriventricular leukomalacia (Perinatal neurological disorder)\tOrthoses, Upper Limb, Elbow (Medical Device)\tLevel 1 Neonatal Death in a Term Live Birth (Intellectual Product)\trecruitment period (Clinical Trial Period)", + "output": "Orthoses, Upper Limb, Elbow (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as roundleafed dogwood.\nConcepts: suppression by symbiont of host receptor-mediated signal transduction (modulation by symbiont of host receptor-mediated signal transduction)\t(Potency Unit)\tdryers (Diagnostic, Therapeutic, and Research Equipment)\tDomains, HMG-Box (Amino Acid Sequence)\tcornus circinata/roundleafed (Pharmacologic Substance)", + "output": "cornus circinata/roundleafed (Pharmacologic Substance)" + }, + { + "input": "Definition: SGRQ-C Questionnaire Question described as st. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) Some more questions about your cough and breathlessness: I am short of breath when I talk.\nConcepts: FACT-BRM Version 4 - I Feel Close to My Friends (Intellectual Product)\toligosaccharide alpha-1,6-glucosidase activity (Molecular Function)\tdental structure (Oropharyngeal)\tapoptotic process involved in heart morphogenesis (Cell Function)\tSGRQ-C - Short of Breath When Talk (Intellectual Product)", + "output": "SGRQ-C - Short of Breath When Talk (Intellectual Product)" + }, + { + "input": "Definition: Pain Assessment Tool described as a 52 item chronic pain inventory.\nConcepts: West Haven-Yale Multidimensional Pain Inventory (Pain Assessment Tool)\tdementia frontotemporal (Frontotemporal Lobar Degeneration)\tRespiratory System Findings Sponsor Defined Identifier (Intellectual Product)\tvagus nerve development (cranial nerve development)\tRenal lithiasis (Urinary Bladder)", + "output": "West Haven-Yale Multidimensional Pain Inventory (Pain Assessment Tool)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: CH ASSAY 50 (Assay)\tAustronesian Language (Language)\tBlades, Knife (Medical Device)\tDefence reflex (Reflex Motor and Equilibrium Functions)\tVulvovaginal Region (Body Location or Region)", + "output": "Blades, Knife (Medical Device)" + }, + { + "input": "Definition: Soft Tissue Angiosarcoma described as a malignant vascular neoplasm arising from the superior vena cava.\nConcepts: Grooming (Individual Behavior)\tRhus glabra / smooth sumach (Organic Chemical)\tCollagen product (Pharmaceutical Preparations)\tAvoidance Learning (Mental Process)\tSuperior Vena Cava Angiosarcoma (Soft Tissue Angiosarcoma)", + "output": "Superior Vena Cava Angiosarcoma (Soft Tissue Angiosarcoma)" + }, + { + "input": "Definition: Professional or Occupational Group described as a licensed physician, who has completed a residency program in Neurology, and who has additional training, experience, and competence in the standards of performance and interpretation of Magnetic Resonance Imaging (MRI / MRA) of the head, spine, and peripheral nerves, and Computed Tomography (CT) of the head and spine. Physicians are trained in the administration of contrast media and the recognition and treatment of adverse reactions to contrast media. Neuroimaging training encompasses thorough knowledge of clinical neurology, neurophysiology, neuroanatomy, neurochemistry, neuropharmacology, and dynamics of cerebrospinal fluid circulation. Physicians possess special expertise in the technical aspects and clinical applications of each of the modalities and techniques of neuroimaging.\nConcepts: Extraction and Processing Industry (Industry)\tCell Banking, Master and Working Cell Bank Preparation and/or Maintenance (Cell Culture)\tOrganizing Pneumonia, Cryptogenic (idiopathic nonspecific interstitial pneumonitis)\tAllopathic & Osteopathic Physicians; Radiology, Diagnostic Neuroimaging (Professional or Occupational Group)\tE/A skrn'g nvrnmntl chem.bl (Chemical analysis)", + "output": "Allopathic & Osteopathic Physicians; Radiology, Diagnostic Neuroimaging (Professional or Occupational Group)" + }, + { + "input": "Definition: Heterotrimeric G Protein Subunit Gene described as this gene is involved in signal transduction and negative regulation of synaptic transmission.\nConcepts: nitrilotriacetate monooxygenase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tG Protein Subunit Beta 1 Gene (Heterotrimeric G Protein Subunit Gene)\tAnteater, Spiny (Family Tachyglossidae)\thsNuf2 (Biologically Active Substance)\tUncuffed Dialysis Catheter (catheter device)", + "output": "G Protein Subunit Beta 1 Gene (Heterotrimeric G Protein Subunit Gene)" + }, + { + "input": "Definition: Laboratory Procedure described as light Microscopy is a technique for producing visible images of structures or details which are too small to be otherwise seen by the human eye. It involves passing light transmitted through or reflected from the subject through a series of lenses to be detected directly by the eye, imaged on a photographic plate, or captured digitally.\nConcepts: Microscopy, Hand-Held (ObservationMethod - CodeSystem)\tExtracorporeal haemodialysis route (Extracorporeal route)\tKERATOCONUS WITH CATARACT (Hereditary disorder of the visual system)\tRorschach Test (Diagnostic Procedure)\tSoftware, Digital Radiographic System, Mammographic (Software, Digital Radiographic System)", + "output": "Microscopy, Hand-Held (ObservationMethod - CodeSystem)" + }, + { + "input": "Definition: Anatomical Abnormality described as underdevelopment of the vestibule of the inner ear.\nConcepts: Hypoplasia of the vestibule of the inner ear (Anatomical Abnormality)\tMetabolic Response (Finding)\tEpidermal Growth Factor Receptor Kinase (Enzyme)\trRNA metabolism (ncRNA metabolic process)\tsyntrophin complex location (Cell Component)", + "output": "Hypoplasia of the vestibule of the inner ear (Anatomical Abnormality)" + }, + { + "input": "Definition: Mycobacterium Infections, Nontuberculous described as infections with nontuberculous mycobacteria (atypical mycobacteria): M. kansasii, M. marinum, M. scrofulaceum, M. flavescens, M. gordonae, M. obuense, M. gilvum, M. duvali, M. szulgai, M. intracellulare (see MYCOBACTERIUM AVIUM COMPLEX;), M. xenopi (littorale), M. ulcerans, M. buruli, M. terrae, M. fortuitum (minetti, giae), M. chelonae, M. leprae.\nConcepts: Mycobacterium Infection, Nontuberculous (Mycobacterial infectious disorders)\tdsRNA Virus (RNA Viruses)\tSpecial or built up chair (Finding)\tmitral (Qualitative Concept)\tphysiopathology (physiological aspects)", + "output": "Mycobacterium Infection, Nontuberculous (Mycobacterial infectious disorders)" + }, + { + "input": "Definition: Equine Experimental Organism Diagnosis described as melanoma that occurs in a horse.\nConcepts: CFTR Pathway (Molecular Function)\theart imaging/visualization/scanning (cardiography)\tprocess utilizing autophagic mechanism (Cell Function)\tPeutz-Jeghers Polyp of the Stomach (Gastric Hamartoma)\tHorse Melanoma (Equine Experimental Organism Diagnosis)", + "output": "Horse Melanoma (Equine Experimental Organism Diagnosis)" + }, + { + "input": "Definition: something described as the minimum rate of positive pressure change over time within the left ventricle (systole).\nConcepts: Stromal Sarcoma of the Prostate (Prostate Sarcoma)\tPODCI129 (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tPeriodic Target Accrual Number (Numbers)\tLeft Ventricular Minimum Positive dP/dt (Finding)\tbreast tumour (Neoplasm by anatomical site)", + "output": "Left Ventricular Minimum Positive dP/dt (Finding)" + }, + { + "input": "Definition: PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - If you answered \"sometimes\" or \"never or rarely\" to Question 60 above, was your child's activity limited by: Fear the other kids won't like him/her?\nConcepts: Esophagitides (Esophagitis)\tPODCI Adolescent Parent-Reported Version - Friends Limited by: Fear (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tintracellular calcium activated chloride channel activity (ion gated channel activity)\tsynaptic target inhibition (negative chemotaxis)\tPolyneuropathy Organomegaly (Paraproteinemias)", + "output": "PODCI Adolescent Parent-Reported Version - Friends Limited by: Fear (PODCI Adolescent Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Microtubule-Organizing Center described as a microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis.\nConcepts: Ceramide Kinase-like Protein (Amino Acid, Peptide, or Protein)\tprotection of DNA demethylation of female pronucleus (Genetic Function)\tVery Low Birth Weight (Birth Weight)\tImmunoblasts/Lymphocytes (Blood Cell Count Ratio Measurement)\tequatorial microtubule organizing center (Microtubule-Organizing Center)", + "output": "equatorial microtubule organizing center (Microtubule-Organizing Center)" + }, + { + "input": "Definition: Body Location or Region described as the part of area p24d located in the lower bank of the cingulate sulcus, where the sulcus bounds the most caudal part of the anterior cingulate gyrus in the human. The part in the upper bank of the sulcus is area p24dd. It is not found in the macaque where area p24d is not subdivided ( Vogt-2012 ).\nConcepts: registries (Intellectual Product)\tfastigial nucleus development (Organ or Tissue Function)\tProduct containing gemtuzumab ozogamicin (Immunomodulators)\tProduct containing vitamin K1 (Vitamin K containing hemostatics)\tarea 24dv (Body Location or Region)", + "output": "area 24dv (Body Location or Region)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of arginine present in a sample.\nConcepts: dihydroxyfluorene dioxygenase activity (Molecular Function)\targinine test (Amino acids measurement)\tIsolated lissencephaly type 1 without known genetic defect (Classical Lissencephaly)\tFailure to thrive secondary to recurrent infections (Finding)\tN-Nitrosomethylvinylamine (Carcinogenic Nitrosamine)", + "output": "arginine test (Amino acids measurement)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a self-report screening tool, originally developed by Tomlinson et al. in 2013, that is used for symptom assessment in children with cancer and pediatric hematopoietic stem cell transplantation recipients.\nConcepts: SSPedi (Intellectual Product)\tSchiller-Duval Body (Finding)\t4D (Dimensionality)\tM\u00f6bitz II (Disease or Syndrome)\tBladder Cancer pT2b TNM Finding v6 (Bladder Cancer Pathologic Primary Tumor TNM Finding v6)", + "output": "SSPedi (Intellectual Product)" + }, + { + "input": "Definition: Syringes, Plunger, Protective described as plunger syringes with a needle preattached to their Luer-lock tip that are designed to provide needlestick protection (safety). These syringes include some mechanism (manually positioned or activated) intended either to shield, blunt, or recess the needle after use or, by some other means, lessen the possibility of contact of the healthcare provider with the sharp needle. Luer-lock tapers include an internally threaded skirt or other structure around the taper, adding additional strength to the connection with a female Luer taper for a short time and low-pressure applications.\nConcepts: regulation of ribosomal small subunit transport from nucleus to cytoplasm (Cell Function)\tSyringes, Plunger, Protective, Luer Lock (Syringes, Plunger, Protective)\tFAC05709 (FACT/GOG-NTX Version 4 Questionnaire Question)\tSnares, Gastrointestinal Tract, Endoscopic (Snare instrument)\tCDISC SDTM Observational Study Biospecimen Retention Terminology (Intellectual Product)", + "output": "Syringes, Plunger, Protective, Luer Lock (Syringes, Plunger, Protective)" + }, + { + "input": "Definition: Ligase described as monofunctional C1-tetrahydrofolate synthase, mitochondrial (978 aa, ~106 kDa) is encoded by the human MTHFD1L gene. This protein is involved in the modulation of tetrahydrofolate synthesis and other folate metabolic processes.\nConcepts: Gerbil (Mammal)\tBulbomembranous Urethral Malignant Neoplasm (Neoplastic Process)\tcellular response to boron-containing substance deprivation (cellular response to chemical stress)\tFormyltetrahydrofolate Synthetase (Ligase)\tTransient pseudohypoaldosteronism (Pseudohypoaldosteronism)", + "output": "Formyltetrahydrofolate Synthetase (Ligase)" + }, + { + "input": "Definition: something described as the most recently recorded sum of diameters minus the lowest sum of diameters previously recorded.\nConcepts: Surgery, Image Guided (Surgical Procedure by Method)\twound surgical (Effect of surgery)\tUmbilical Cord Occlusion (Umbilical cord finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ACTN4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tAbsolute Change Nadir in Sum of Diam (Quantitative Concept)", + "output": "Absolute Change Nadir in Sum of Diam (Quantitative Concept)" + }, + { + "input": "Definition: Finding described as potential for damage to skin, soft tissue, joints, ligaments, bones, eyes, nerves and blood and lymph vessels as a result of the mechanism of compression or stretching that occurs while positioning the patient to expose the surgical site especially in patients identified at risk for perioperative pressure injury.\nConcepts: Childhood Pineoblastoma (Neoplastic Process)\tTMF (Manufactured Object)\tAt risk for perioperative-positioning injury (Safety)\tFood and Water Consumption Group Identifier (Intellectual Product)\textrinsic to lumenal leaflet of plastid thylakoid membrane (extrinsic component of plastid inner membrane)", + "output": "At risk for perioperative-positioning injury (Safety)" + }, + { + "input": "Definition: regulation of chondrocyte differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.\nConcepts: Fertility Preservations (Reproductive care)\tinhibition of methanofuran metabolism (regulation of methanofuran metabolic process)\tADENOCARCINOMA, DUCTAL CELL, MALIGNANT (Neoplastic Process)\tnegative regulation of chondrocyte differentiation (regulation of chondrocyte differentiation)\tLDL RECEPTOR RELATED PROTEIN 001 (Amino Acid, Peptide, or Protein)", + "output": "negative regulation of chondrocyte differentiation (regulation of chondrocyte differentiation)" + }, + { + "input": "Definition: negative regulation of endothelial cell differentiation described as any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell development.\nConcepts: negative regulation of endothelial cell development (Cell Function)\tNEEDLE, HYPODERMIC, SINGLE LUMEN (SYRINGES/NEEDLES)\tDensity, Population (geographic population)\tTesticular Cancer pN2 TNM Finding v7 (Testicular Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tSol for Reconstitution (Solution Dosage Form)", + "output": "negative regulation of endothelial cell development (Cell Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a radioconjugate containing hydroxydiphosphonate (HDP) labeled with the metastable radioisotope technetium Tc (99mTc), with radioimaging activity. Upon intravenous administration, skeletal uptake of technetium Tc-99m HDP occurs as a function of skeletal blood flow and osteogenic activity. HDP has a specific affinity for hydroxyapatite crystals in bone where abnormal accumulation of increased osteoid mineralization has occurred. Labeling of HDP with 99mTc allows gamma scintigraphic imaging of areas of abnormal osteogenesis associated with malignant bone lesions.\nConcepts: Stage IIB Appendiceal Carcinoma AJCC v8 (Neoplastic Process)\tNose width line (Body Location or Region)\tMSTN gene (Transforming Growth Factor-Beta Family Gene)\tTc-99m Hydroxydiphosphonate (Pharmacologic Substance)\tcellooligosaccharide catabolic process (Molecular Function)", + "output": "Tc-99m Hydroxydiphosphonate (Pharmacologic Substance)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.\nConcepts: Acinic Cell Carcinoma of the Minor Salivary Gland (Minor Salivary Gland Adenocarcinoma)\tdonor regulatory T lymphocytes (Cell)\torganophosphonate biosynthetic process (cellular biosynthetic process)\tN-glycan processing (glycoprotein metabolic process)\tH3 RECEPT (Histamine Receptor)", + "output": "organophosphonate biosynthetic process (cellular biosynthetic process)" + }, + { + "input": "Definition: Organic Chemical described as an oligosaccharide protein modification that is synthesized by molluscan cells.\nConcepts: Tiredness Score 10 (Intellectual Product)\tMOLLUSCAN TYPE GLYCAN (Structural Modifier)\tPromyelocytic Leukemia Zinc Finger Protein (Biologically Active Substance)\tBradyarrhythmia terms, nonspecific (Classification)\tCD44 - Cluster of diff ag 44 (Chondroitin Sulfate Proteoglycans)", + "output": "MOLLUSCAN TYPE GLYCAN (Structural Modifier)" + }, + { + "input": "Definition: Research Activity described as the conducting, guidance, regulation, direction, or supervision of a clinical trial.\nConcepts: Strip Dosing Unit (Potency Unit)\tTest Equating (Thesaurus of Psychological Index Terms)\tPI-88 (Pharmacologic Substance)\tTrial Mgmt (Management procedure)\tresponse to prostaglandin E stimulus (response to ketone)", + "output": "Trial Mgmt (Management procedure)" + }, + { + "input": "Definition: something described as an oxidized form of the glycoprotein avidin, that can be used as a linking agent for tissue-pretargeted radionuclide therapy. Upon intralesional administration, the aldehyde groups of oxidized avidin strongly bind to the amino groups on tissue proteins, via the formation of Schiff bases. As avidin is able to strongly bind to biotin, intravenous administration of radiolabeled biotin may lead to the selective eradication of the pre-targeted tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C113800\" active clinical trials using this agent.\nConcepts: Refractory -RETIRED- (Functional Concept)\tKDO metabolic process (Molecular Function)\tCV (Domain)\tGrade 1 Gastro-intestinal Bleeding Neonatal (Finding)\tOxidized Avidin (Indicator, Reagent, or Diagnostic Aid)", + "output": "Oxidized Avidin (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: regulation of cell junction assembly described as any process that stops, prevents or reduces the frequency, rate or extent of cell junction assembly.\nConcepts: down-regulation of cell junction assembly (negative regulation of cellular component organization)\tMISPEC (Biospecimen Type)\tLVG Hamster (Mammal)\tselpercatinib (RET Inhibitor)\tRadiopharmaceutical Volume (Volume)", + "output": "down-regulation of cell junction assembly (negative regulation of cellular component organization)" + }, + { + "input": "Definition: something described as experimental devices used in inhalation studies in which a person or animal is either partially or completely immersed in a chemically controlled atmosphere.\nConcepts: Fatal infantile lactic acidosis co-occurrent with methylmalonic aciduria (Mitochondrial DNA depletion syndrome encephalomyopathic form)\t17q25 (Cell Component)\tEnvironmental Chambers (Equipment and Supplies)\tSinus Node Arteries (Atrial branch of right coronary artery)\tmethyl mercaptan oxidase activity (Molecular Function)", + "output": "Environmental Chambers (Equipment and Supplies)" + }, + { + "input": "Definition: Disease or Syndrome described as gastrointestinal symptoms characterized by chronic abdominal pain and altered bowel habits in the absence of any organic cause.\nConcepts: Antibiotic 9663 (Organic Carcinogen)\tAnn Arbor Stage I Mantle Cell Lymphoma (Mantle Cell Lymphoma by Ann Arbor Stage)\tPHQ-15 - Constipation, Loose Bowels, or Diarrhea (Intellectual Product)\tGastric Mucus Secretion Inhibition (Gastrointestinal Secretory Inhibition)\tIrritable Colon (Gastrointestinal tract finding)", + "output": "Irritable Colon (Gastrointestinal tract finding)" + }, + { + "input": "Definition: NCI Thesaurus described as a living entity.\nConcepts: Marrow CR (Disease Response)\t2-deoxy-3-O-[(3R)-3-hydroxytetradecanoyl]-2-{[(3R)-3-hydroxytetradecanoyl]amino}-1-O-phosphono-alpha-D-glucopyranose metabolism (phosphate-containing compound metabolic process)\torganism (Organism)\tFree fluid (Pathologic Function)\thydrocarbons (Hydrocarbons)", + "output": "organism (Organism)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure.\nConcepts: AVL02-List B Word 3 (Intellectual Product)\tI have had trouble concentrating (Intellectual Product)\tPartial duplication of the outermost bone of the middle finger (Anatomical Abnormality)\tnectary development (developmental process involved in reproduction)\tVendor Oversight Document (Document type)", + "output": "nectary development (developmental process involved in reproduction)" + }, + { + "input": "Definition: Conceptual Entity described as an indication as to whether the sample contains viable (capable of life or normal growth and development) cells or tissues.\nConcepts: down-regulation of cell proliferation in dorsal spinal cord (Biologic Function)\tBenign Childhood Neoplasm of Central Nervous System (Benign neurologic neoplasms)\tSample Viability Indicator (Conceptual Entity)\tlobule 3 (Body Part, Organ, or Organ Component)\tImpacted tooth (clinical disorder) [Ambiguous] (examination of teeth)", + "output": "Sample Viability Indicator (Conceptual Entity)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine.\nConcepts: adrenaline catabolic process (catecholamine catabolism)\toccasional accident (Clinical or Research Assessment Answer)\tTaste alteration (Taste Perception)\tAnalyzers, Laboratory, Blood (Analyzers, Laboratory)\thereditary progressive bulbar paralysis with deafness (Auditory system hereditary disorder)", + "output": "adrenaline catabolic process (catecholamine catabolism)" + }, + { + "input": "Definition: Quantitative Concept described as unit of catalytic activity concentration defined as activity equal to a picokatal per one liter of the system volume.\nConcepts: Heparin-Binding Neurotrophic Factor (Biologically Active Substance)\tStage IIIA Gallbladder Cancer (Stage III Gallbladder Cancer AJCC v7)\tProportion of energy requirement from protein and protein derivatives in 24 hours (Quantitative Concept)\tpkat/L (Quantitative Concept)\tSea-water (Environment)", + "output": "pkat/L (Quantitative Concept)" + }, + { + "input": "Definition: something described as catalysis of the synthesis of free D-serine from L-serine.\nConcepts: Choreoathetosis, Hypothyroidism, And Neonatal Respiratory Distress (Autosomal dominant hereditary disorder)\tdisease-specific survival rate (Quantitative Concept)\tserine racemase activity (Molecular Function)\ttrisomy; syndrome, 21 (Trisomy)\tKali iodatum / potasssium iodide (Homeopathic remedies letter K)", + "output": "serine racemase activity (Molecular Function)" + }, + { + "input": "Definition: something described as plain (nonimpregnated) dressings designed to cover and protect a wound without any additional functions. These dressings are usually made of raw materials such as natural fibers (e.g., cotton, alginate), biological products (e.g., collagen), synthetic materials (e.g., polymers), or of materials. Nonimpregnated dressings are used mainly to maintain a moist environment, to absorb exudates, and/or to prevent contact with bacteria.\nConcepts: Ovarian Cancer and Primary Peritoneal Carcinoma TNM Finding v7 (Female Reproductive System Cancer TNM Finding v7)\tregulation of intestinal absorption (Organ or Tissue Function)\tLymph Nodes (Body Part, Organ, or Organ Component)\t4-Fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide (Signal Transduction Inhibitor)\tDressings, Nonimpregnated (Medical Device)", + "output": "Dressings, Nonimpregnated (Medical Device)" + }, + { + "input": "Definition: Organism Function described as the chemical reactions and pathways involving an acetate ester, any carboxylic ester where the carboxylic acid component is acetic acid.\nConcepts: Zileuton product (Leukotriene Antagonists)\tNeutralization (Action)\tSegregation, Chromosome (Mitotic Chromosomal Process)\tacetate ester metabolism (Organism Function)\tLEC-5 Standard Version - Combat or Exposure to War-Zone: Not Apply (LEC-5 Standard Version Questionnaire Question)", + "output": "acetate ester metabolism (Organism Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as reduction in caloric intake without reduction in adequate nutrition. In experimental animals, caloric restriction has been shown to extend lifespan and enhance other physiological variables.\nConcepts: Thoracic segment of trunk (Region of trunk)\tprofessor (Educational Personnel & Administration)\tPRLX 93936 (Antineoplastic Agents)\tRestricted Diet, Calorie (Actions to lose weight)\tReduced hair growth in temporal region (Congenital Abnormality)", + "output": "Restricted Diet, Calorie (Actions to lose weight)" + }, + { + "input": "Definition: Cell described as a preparation of Epstein-Barr virus (EBV) reactive cytotoxic T-lymphocytes (CTLs) in which the programmed cell death 1 (PD-1; PDCD1; CD279; programmed death-1) gene is deleted, with potential immunomodulating activity. Upon administration of the PD-1 knockout EBV-specific CTLs, these CTLs target and induce selective toxicity in EBV-positive cancer cells. This results in cell lysis and inhibition of cancer cell proliferation. Expression of PD-1, an inhibitory receptor expressed on activated T-cells, plays a key role in CTL suppression, T-cell exhaustion and CTL apoptosis. PD-1 knockout abrogates T-cell exhaustion and increases T-cell activity and cytotoxicity. EBV, a ubiquitous human herpesvirus, is associated with various cancer cell types.\nConcepts: Ambulatory Multitherapy Infusion Pumps (Medical Device)\tStage IIB Merkel Cell Carcinoma AJCC v7 (Neoplastic Process)\tPD-1 knockout EBV-CTLs (Cell)\tHuman rhinovirus C (Rhinovirus)\tConnective and Soft Tissue Finding (Finding by Site or System)", + "output": "PD-1 knockout EBV-CTLs (Cell)" + }, + { + "input": "Definition: Cell Function described as any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.\nConcepts: anatomy finger (Body part)\twater solubility (Quantitative Concept)\tphagosome acidification (intracellular pH reduction)\tComputed tomography of chest and abdomen without contrast (CT of chest without contrast)\tHealth System Guidance (Health Promotion)", + "output": "phagosome acidification (intracellular pH reduction)" + }, + { + "input": "Definition: Intellectual Product described as a unique code used by publishers in the identification and exchange of the content of a digital object, such as a journal article, web document, or other item of intellectual property. The DOI consists of two parts: a prefix assigned to each publisher by the administrative DOI agency and a suffix assigned by the publisher that may be any code the publisher chooses.\nConcepts: Numeric Conversion (Calculation)\tDOI (Intellectual Product)\tGynatresias (Female Genital Diseases)\tregulation of action potential firing threshold (regulation of action potential)\tAdenocarcinoma of paratestis (Adenocarcinoma)", + "output": "DOI (Intellectual Product)" + }, + { + "input": "Definition: something described as a benzenesulfonamide-phthalimidine that tautomerizes to a BENZOPHENONES form. It is considered a thiazide-like diuretic.\nConcepts: 9: 132935667-132963441 (Spatial Concept)\tFace structure (Head)\tOropharyngeal Cancer pMX TNM Finding v6 (Oropharyngeal Cancer Pathologic Distant Metastasis TNM Finding v6)\tMajor Axis Cross-sectional Diameter, End Ventricular Systole (Finding)\tChlortalidone product (Organic Chemical)", + "output": "Chlortalidone product (Organic Chemical)" + }, + { + "input": "Definition: General Qualifier described as of, involving, or concerning a specific, local region such as a home or country.\nConcepts: Ensuring one's physical comfort (Looking after one's health)\tresponse to acetate (response to organic substance)\tdownregulation of beta-amyloid clearance (Biologic Function)\tGrade 4 Urostomy stenosis (Urostomy Stenosis, CTCAE)\tDomestic (General Qualifier)", + "output": "Domestic (General Qualifier)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate.\nConcepts: Muscle cramps with exercise (Spasm)\tRO-237553 (Differentiation Inducer)\tphospholipid dephosphorylation (Dephosphorylation)\tglycogen phosphorylase activity (Molecular Function)\tpolyphosphate:AMP phosphotransferase activity (phosphotransferase activity, phosphate group as acceptor)", + "output": "glycogen phosphorylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a chromosome band present on 17q\nConcepts: Augmentation/Reconstruction Implants, Facial, Nasal (Augmentation/Reconstruction Implants, Facial)\t17q21.3 (Chromosome band)\tMotivation Score 3 (Intellectual Product)\tLiter per Hour per Microgram per Kilogram (Quantitative Concept)\tStage IV Head and Neck Squamous Cell Cancer (Neoplastic Process)", + "output": "17q21.3 (Chromosome band)" + }, + { + "input": "Definition: Wall of right atrium described as epicardium of atrium which is attached to the myocardium of right atrium.\nConcepts: Dysfunctional alternative complement pathway (Abnormality of the alternative complement pathway)\tCanine Gastrointestinal Stromal Tumor (Canine Neoplasm)\tRight atrial epicardium (Epicardium of atrium)\tcarnitine (Pharmacologic Substance)\tNeutrophilic Infiltrate (Acute inflammation)", + "output": "Right atrial epicardium (Epicardium of atrium)" + }, + { + "input": "Definition: something described as initial concentration divided by the surface area. Given only for bolus IV models.\nConcepts: IVD Test Reagent/Kits, Serology, Parasite, Cryptosporidium Species (Medical Device)\tInternal Abdominal Ring (Superficial Abdominal Muscle)\tCGI Generic Modification Version - Severity (CGI Generic Modification Version Questionnaire Question)\tInitial Concentration Normalized by Surface Area (Initial Concentration)\t17q25.2-q25.3 (Chromosome band)", + "output": "Initial Concentration Normalized by Surface Area (Initial Concentration)" + }, + { + "input": "Definition: Disease or Syndrome described as rickets caused by a defect in the VDR gene, encoding the vitamin D receptor. This form of rickets is characterized by hypocalcemia, elevated 1,25-dihydroxyvitamin D (calcitriol) concentrations, and may also manifest with alopecia.\nConcepts: Protein-L-Isoaspartate Methyltransferase (Amino Acid, Peptide, or Protein)\tAbnormal collarbone (Anatomical Abnormality)\tVDDR2A (Disease or Syndrome)\tsubfornical region (motor lateral hypothalamus)\tisocitrate O-dihydroxycinnamoyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "VDDR2A (Disease or Syndrome)" + }, + { + "input": "Definition: RouteBySite described as administration within the marrow of the bone.\nConcepts: myristoyl-CoA hydrolase activity (Molecular Function)\tProblem with Sterilization (Medical Device Disinfection or Sterilization Issue)\tnfcltynew msgther ntak 10min (Health Care Activity)\tIntraosseous Route of Administration (Musculoskeletal route)\tGeneralized muscle weakness (Myopathy)", + "output": "Intraosseous Route of Administration (Musculoskeletal route)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of hepatocellular carcinoma, following the rules of the TNM AJCC v8 classification system.\nConcepts: Postoperative Hernia (Disorder of abdominal wall)\tPowder for Emulsion for Injection Dosage Form (Powder for solution for injection)\tWeight percentile for height (Body Weight)\tHepatocellular Carcinoma Clinical TNM Finding v8 (Finding)\tRopivacaine (Amide and amide derivative)", + "output": "Hepatocellular Carcinoma Clinical TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as patient Health Questionnaire Screener Version (PHQ Screener Version) Over the last 2 weeks, how often have you been bothered by feeling down, depressed, or hopeless?\nConcepts: Labor management third stage out-of-hospital each 60 minutes (Health Care Activity)\tPHQ0302B (Intellectual Product)\tSalmonella bone infection (Osteomyelitis)\tAcrylic Curing Units, Dental (Medical Device)\tPRCA1 (Gene or Genome)", + "output": "PHQ0302B (Intellectual Product)" + }, + { + "input": "Definition: Immune Response Regulation Pathway described as the inflammatory response associated with asthma is characterized by the recruitment of eosinophils from the bronchial microcirculation in response to the regulated local production of chemoattractant molecules. Although several chemical mediators are active upon eosinophils in vitro, a central role in eosinophil accumulation in vivo is emerging for the C-C chemokine eotaxin, which was first identified in a guinea pig model of allergic airway inflammation using protein purification and microsequencing. Eotaxin is the dominant eosinophil-selective chemoattractant in this model, acting to cause both local eosinophil recruitment to the lung, and the release of a rapidly mobilizable pool of bone marrow eosinophils in cooperation with IL-5. Eotaxin and eotaxin-2 are potent stimulators of eosinophils, signaling exclusively via high affinity binding to the receptor CCR3. C-C chemokines, including MCP-3, MCP-4, and RANTES, also stimulate eosinophils via CCR3, although they show less leukocyte selectivity as they additionally signal via other chemokine receptors expressed on a range of leukocytes, including lymphocytes and monocytes. CCR3 is expressed in high numbers on eosinophils and is thought to be the major eosinophil chemokine receptor. Blockade of CCR3 in vivo inhibits eosinophil recruitment in response to eotaxin in both the guinea pig and mouse. More recently, CCR3 expression has been demonstrated on basophils and Th2-type T cells, suggesting possible roles for CCR3 in the genesis and maintenance of allergic inflammation. CCR3 is therefore a major target for anti-inflammatory drug development.\nConcepts: Infantile haemangioma (Soft tissue lesion)\tFermentative Gram-negative Rod (Microorganism)\tAllergy Chemokine Network Pathway (Cell Function)\tEdwards syndrome (Disease or Syndrome)\tPlatinum-Based Chemotherapy (Other antineoplastic agents in ATC)", + "output": "Allergy Chemokine Network Pathway (Cell Function)" + }, + { + "input": "Definition: Nervous System Neoplasm described as a neuroectodermal tumor composed of neoplastic neural elements.\nConcepts: Acute lymphoblastic leukaemia recurrent (Recurrent Lymphoproliferative Disorder)\tFactor For Inversion Stimulation Protein (DNA-Binding Proteins)\tSpongioneuroblastoma (Neoplastic Process)\tglucoside transmembrane transporter activity (carbohydrate derivative transmembrane transporter activity)\tmacropain binding (protein-containing complex binding)", + "output": "Spongioneuroblastoma (Neoplastic Process)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene plays a role in DNA repair.\nConcepts: 99mTc demobesin-4 (Radioconjugate)\tUDG1 (Hydrolase Gene)\tgrade 2 intraventricular hemorrhage neonatal (Perinatal intraventricular hemorrhage)\tviral maturation (viral process)\tDecreased urinary 3-methylhistidine (Finding)", + "output": "UDG1 (Hydrolase Gene)" + }, + { + "input": "Definition: oxyquinoline described as one of the halogenated 8-quinolinols widely used as an intestinal antiseptic, especially as an antiamebic agent. It is also used topically in other infections and may cause CNS and eye damage. It is known by very many similar trade names world-wide.\nConcepts: mannosyl-oligosaccharide mannosidase activity (alpha-mannosidase activity)\tvaginal preparations iodoquinol vaginal (vaginal preparations)\tDiseases, Mannosidase Deficiency (Disease or Syndrome)\tMelan-A/MAGE-3.DP4 Peptide Vaccine (Immunologic Factor)\tCervical Cancer pT1b2 TNM Finding v7 (Cervical Cancer pT1b TNM Finding v7)", + "output": "vaginal preparations iodoquinol vaginal (vaginal preparations)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH.\nConcepts: DefinedSubstanceAdministration.doseRegimen (Intellectual Product)\tChoroidal and Ciliary Body Melanoma pT4b TNM Finding v8 (Choroidal and Ciliary Body Melanoma pT4 TNM Finding v8)\tcholate 7-alpha-dehydrogenase activity (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tIntracerebroventricular Infusion (Therapeutic or Preventive Procedure)\tfear of cancer (Phobia, Specific)", + "output": "cholate 7-alpha-dehydrogenase activity (steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Manages specimen collection, handling, and disposition described as performs the collection of blood from a vein for diagnostic blood samples for testing.\nConcepts: coronary ligament (Structure of ligament of liver)\tPerforms venipuncture for blood specimens (Manages specimen collection, handling, and disposition)\t16q21 (Chromosome band)\tIVD Panels, Human Genetics, Metabolic Disorder, Myopathy, Comprehensive, Mutation (Medical Device)\tEPIC-26 - Ability to Have an Erection (Intellectual Product)", + "output": "Performs venipuncture for blood specimens (Manages specimen collection, handling, and disposition)" + }, + { + "input": "Definition: something described as an elevated proportion of T cells that express human leukocyte antigen (HLA)-DR. HLA-DR is an MHC class II cell surface receptor that presents antigens (peptides of at least 9 amino acids), thereby constituting a ligand for the T-cell receptor. HLA-DR can be upregulated in response to immune stimulation.\nConcepts: Progestogen preparation (Hormone)\tMTLRP (GHRL gene)\tLVEF - Left ventricular ejection fraction (Left Ventricular Function)\tIncreased proportion of HLA DR+ T cells (Abnormal T cell subset distribution)\tPortion of seminiferous tubule fluid (Body Substance)", + "output": "Increased proportion of HLA DR+ T cells (Abnormal T cell subset distribution)" + }, + { + "input": "Definition: Family Hymenolepididae described as the smallest species of TAPEWORMS. It is the only cestode that parasitizes humans without requiring an intermediate host.\nConcepts: internal leaflet of cell outer membrane (Cell Component)\tDrug Delivery Microdevice (Drug Delivery Systems)\t5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)- (Second generation cephalosporin)\tC5-methylcytidine-containing RNA binding (RNA Binding)\tDwarf tapeworm (Class Cestoda)", + "output": "Dwarf tapeworm (Class Cestoda)" + }, + { + "input": "Definition: Photography described as recording serial images of a process at regular intervals spaced out over a longer period of time than the time in which the recordings will be played back.\nConcepts: Watsu each 15 minutes (Oriental massage)\tBRCA-Mutated Breast Carcinoma (Neoplastic Process)\tvantictumab (Amino Acid, Peptide, or Protein)\tTime Lapse Imaging (Diagnostic Procedure)\tPlannedActivity.repeatQuantity (Repeat Quantity)", + "output": "Time Lapse Imaging (Diagnostic Procedure)" + }, + { + "input": "Definition: Collateral ganglion described as sympathetic and parasympathetic ganglia within pelvic plexi\nConcepts: sym-norspermidine synthase activity (transferase activity, transferring alkyl or aryl (other than methyl) groups)\tSet of pelvic ganglia (Set of nerves)\tTumor Results Domain (Intellectual Product)\tSchwann cell migration (Cell Function)\tmenatetrenone catabolic process (menaquinone metabolic process)", + "output": "Set of pelvic ganglia (Set of nerves)" + }, + { + "input": "Definition: something described as using standardized Healing Touch(TM) techniques to clear, energize and balance a client/patient's energy fields. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.\nConcepts: Hlng Touch ea.15min (Energy work)\tAutosomal dominant spastic paraplegia type 4 (Hereditary Autosomal Dominant Spastic Paraplegia)\tFORCEPS, SURGICAL, GYNECOLOGICAL (Medical Device)\tmolybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex location (adenylyltransferase complex)\tPhosphorus-32 product (Therapeutic radioisotope)", + "output": "Hlng Touch ea.15min (Energy work)" + }, + { + "input": "Definition: something described as a bispecific antibody targeting both the human negative immunoregulatory checkpoint receptor programmed cell death protein 1 (PD-1; PDCD1; CD279) and its ligand, human programmed death-ligand 1 (PD-L1; CD274), with potential checkpoint inhibitory, immunostimulating and antineoplastic activities. Upon administration, anti-PD-1/anti-PD-L1 bispecific antibody LY3434172 simultaneously targets and binds to PD-1, which is expressed on a variety of leukocyte subsets including activated T-lymphocytes in the tumor microenvironment (TME), and PD-L1 expressed on tumor cells. This prevents PD-L1 from binding to and activating its receptor PD-1 and inhibits the PD-L1/PD-1-mediated downregulation of T-cell activation and proliferation. This abrogates T-cell inhibition, activates antigen-specific T-lymphocytes and enhances cytotoxic T-cell-mediated tumor cell lysis, which may lead to a reduction in tumor growth. PD-L1 binding to PD-1 on activated T-cells inhibits the expansion and survival of CD8-positive T-cells, suppresses the immune system and results in immune evasion.\nConcepts: Chemokine (C-C motif) Receptor 7 Gene (Gene or Genome)\tPATRITUMAB (Immunologic Factor)\tthirst regulatory center (Body Location or Region)\tLY 3434172 (Antibodies, Bispecific)\tInterleukin 10 Precursor (Immunologic Factor)", + "output": "LY 3434172 (Antibodies, Bispecific)" + }, + { + "input": "Definition: something described as complete and diffuse scarring of glomerulus.\nConcepts: Global glomerulosclerosis (Glomerulosclerosis)\tpeptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid (peptidyl-glutamic acid modification)\tinterleukin-26 biosynthetic process (organonitrogen compound biosynthetic process)\tIntrathoracic goiter (Disease or Syndrome)\tRNA, Transfer, Gln (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "Global glomerulosclerosis (Glomerulosclerosis)" + }, + { + "input": "Definition: something described as mayo-Portland Adaptability Inventory-4 - Leisure and recreational activities.\nConcepts: MPAI1-Leisure and Recreation Activities (MPAI-4 Questionnaire Question)\tStage IVA Differentiated Thyroid Gland Carcinoma AJCC v8 (Neoplastic Process)\thepatitis (Hepatobiliary Disorder)\tmicrocephalus (Physical & Psychosomatic Disorders)\tPUL01-Lifting Heavy Cans Time (Intellectual Product)", + "output": "MPAI1-Leisure and Recreation Activities (MPAI-4 Questionnaire Question)" + }, + { + "input": "Definition: Sympathomimetics, plain described as an imidazole derivative and a direct-acting sympathomimetic amine with vasoconstrictive activity. Upon ocular administration, naphazoline exerts its effect by acting on alpha-adrenergic receptors in the arterioles of the conjunctiva to produce vasoconstriction, resulting in decreased conjunctival congestion and diminished itching, irritation and redness.\nConcepts: Cell Separation Technology (Laboratory Procedures)\tStructure of superior thoracic artery (Structure of axillary artery)\tNaphazoline product (Sympathomimetics used as decongestants)\tPSP2 (Transcription Regulatory Protein)\tULTRASOUND, THROMBOLYSIS SYSTEM (Medical Device)", + "output": "Naphazoline product (Sympathomimetics used as decongestants)" + }, + { + "input": "Definition: enzyme regulator activity described as modulation of the activity of the enzyme ornithine decarboxylase.\nConcepts: ornithine decarboxylase regulator activity (enzyme regulator activity)\tpeptidyl-threonine trans-autophosphorylation (peptidyl-threonine phosphorylation)\tCHROMAFFINOMA, MEDULLARY (Neoplasms)\tUDP Glycosyltransferase 1 Family, Polypeptide A4 Gene (UGT1A4 gene)\tLoss of Bowel and/or Bladder Control at its Worst (Clinical or Research Assessment Question)", + "output": "ornithine decarboxylase regulator activity (enzyme regulator activity)" + }, + { + "input": "Definition: Classification described as oropharynx includes oral cavity bounded by: buccal aspect of lips; palate; floor of mouth; and posterior pharyngeal wall. Included in SMQ Oropharyngeal disorders are terms related to lesions and disorders falling wholly or partly within any part of oral cavity or pharynx; oropharyngeal neoplasms, cysts, and pre-neoplastic lesions; oropharyngeal infections; and gingival disorders. Excluded from SMQ Oropharyngeal disorders are: terms related to lesions or disorders of larynx and structures below larynx; terms related to lesions or disorders of nasal cavity; and investigations, surgical, therapeutic and medical procedures of the oropharynx (e.g., biopsy). SMQ Oropharyngeal neoplasms includes terms for neoplasms that occur within oral cavity\nConcepts: hendra virus (Paramyxovirus, NOS)\tSpermatogenesis maturation arrest (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TSC2 (Medical Device)\tMediastinum hemorrhage (Finding)\tOropharyngeal neoplasms (Classification)", + "output": "Oropharyngeal neoplasms (Classification)" + }, + { + "input": "Definition: Unit of time described as a unit of time equal to one thousand seconds (1E3 seconds).\nConcepts: testosterone 16-beta-hydroxylase activity (monooxygenase activity)\tThyroid Hormone Receptor Gene (Gene or Genome)\tksec (Quantitative Concept)\tCholesterol high (Investigations, CTCAE)\tMyoprocta (Subfamily Dasyproctinae)", + "output": "ksec (Quantitative Concept)" + }, + { + "input": "Definition: Skin Care described as a water-soluble medicinal preparation applied to the skin.\nConcepts: Quality, Unsatisfactory Or Poor (Manufacturing, Packaging or Shipping Problem)\tUnstable (Finding)\tPiperazinum / piperazidine (Pharmacologic Substance)\tCreams, Skin (Cosmetics)\tBone Awls (Awl)", + "output": "Creams, Skin (Cosmetics)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: hydroxymalonate + NAD(+) = H(+) + NADH + oxomalonate.\nConcepts: N(6)-L-threonylcarbamoyladenine synthase activity (Molecular Function)\thydroxymalonate:NAD+ oxidoreductase activity (Molecular Function)\tLEPTIN RECEPTOR OVERLAPPING TRANSCRIPT-LIKE 1 (Gene or Genome)\tCD2-Positive Neoplastic Cells Present (Laboratory or Test Result)\tTendinopathies, Elbow (Tendinopathy)", + "output": "hydroxymalonate:NAD+ oxidoreductase activity (Molecular Function)" + }, + { + "input": "Definition: examination of lacrimal gland described as swelling of the lacrimal duct due to excess fluid.\nConcepts: Lacrimal gland cyst (disorder of eyelid or lacrimal system)\tOTHER INCORRECT ELECTRODE PLACEMENT (Qualitative Concept)\tAtherosclerotic Cardiovascular Disease (Diseases of arteries, arterioles and capillaries)\tNOTCH4 gene (Receptor Gene)\tAcinetobacter parvus Nemec et al. 2003 (Acinetobacter)", + "output": "Lacrimal gland cyst (disorder of eyelid or lacrimal system)" + }, + { + "input": "Definition: something described as CLOVE syndrome has characteristics of congenital lipomatous overgrowth, progressive, complex and mixed truncal vascular malformations and epidermal nevi. To date, less than 15 cases have been reported in the literature. Patients also present with disproportionate fat distribution. CLOVE syndrome may be associated with varying degrees of scoliosis and enlarged bony structures without progressive bony overgrowth. The presence of scoliosis/skeletal manifestations has led to the suggestion that the acronym CLOVE should be expanded to CLOVES.\nConcepts: SPL-108 (Pharmacologic Substance)\tVOR (Molecular Function)\tAppenzeller Sennenhunde (Hound)\tCLOVES SYNDROME (Congenital musculoskeletal anomalies)\tLight periods (Hypomenorrhea)", + "output": "CLOVES SYNDROME (Congenital musculoskeletal anomalies)" + }, + { + "input": "Definition: cell cycle comprising mitosis without cytokinesis described as mitotic division cycles 10 to 13 of the insect embryo. This is the second phase of the syncytial period where nuclei divide in a common cytoplasm without cytokinesis. The majority of migrating nuclei reach the embryo surface during cycle 10, after which they divide less synchronously than before, and the syncytial blastoderm cycles lengthen progressively.\nConcepts: Erythroid dysplasia of bone marrow (Finding of bone marrow erythropoiesis)\tnegative regulation of presynaptic cytosolic calcium concentration (negative regulation of cytosolic calcium ion concentration)\tSellar Mature Teratoma (Sellar Teratoma)\tsyncytial blastoderm mitotic cell cycle (mitotic cell cycle, embryonic)\tCEA assay (Laboratory Procedure)", + "output": "syncytial blastoderm mitotic cell cycle (mitotic cell cycle, embryonic)" + }, + { + "input": "Definition: Congenital Abnormality described as an autosomal recessive form of congenital glaucoma caused by mutation(s) in the CYP1B1 gene, encoding cytochrome P450 1B1.\nConcepts: Vaccinia subgroup virus (Virus)\tPrimary Congenital Glaucoma 3A (Primary congenital glaucoma)\tLipiarrmycin (antibiotics, intestinal)\tReproductive Surgery (Urogenital Surgical Procedures)\tBID wt Allele (BID gene)", + "output": "Primary Congenital Glaucoma 3A (Primary congenital glaucoma)" + }, + { + "input": "Definition: something described as a simian virus 40 (SV40)-based shuttle vector, encoding small interfering RNA (siRNA), with potential antineoplastic activity. The expression of siRNA in target tumor cells transfected with an siRNA-expressing SV40 vector may result in siRNA-mediated silencing of target oncogenes and, so, the inhibition of tumor cell growth and the induction of tumor cell death.\nConcepts: (+)-(5R,6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furyl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (Pharmacologic Substance)\talpha9-beta1 integrin-tenascin complex location (plasma membrane protein complex)\tIncreased triglycerides (LABORATORY ABNORMALITIES)\tsiRNA-expressing SV40 vector (Antineoplastic Biological Agent)\tClobetasol propionate E (clobetasol)", + "output": "siRNA-expressing SV40 vector (Antineoplastic Biological Agent)" + }, + { + "input": "Definition: Intellectual Product described as short-Form McGill Pain Questionnaire-2 - Pain caused by light touch.\nConcepts: BLIND (Research Activity)\tREGURGITATION (Nausea and vomiting)\tdiaminopimelate metabolism (Molecular Function)\tPCI-coagulation factor V complex location (serine protease inhibitor complex)\tSFMP2-Pain Caused by Light Touch (Intellectual Product)", + "output": "SFMP2-Pain Caused by Light Touch (Intellectual Product)" + }, + { + "input": "Definition: something described as a country in Central Europe, east of Germany.\nConcepts: Popliteal pterygium (Pterygium)\tdelta-aminolevulinic acid (Organic acid and organic acid derivative-containing product)\tNon-Neoplastic Muscle Disorder (Non-Neoplastic Soft Tissue Disorder)\tCHROMATOGRAPHIC/FLUOROMETRIC METHOD, CATECHOLAMINES (Medical Device)\tPOL (Central European country)", + "output": "POL (Central European country)" + }, + { + "input": "Definition: Organism Function described as a vestibular reflex by which a response to a linear acceleration stimulus begins with an afferent nerve impulse from a receptor in the otolith and ends with the compensatory action of eye muscles. Signaling never reaches a level of consciousness.\nConcepts: pigment cell differentiation (Cell Function)\tlinear vestibuloocular reflex (Organism Function)\tregulation of chanoclavine-I aldehyde anabolism (regulation of ergot alkaloid biosynthetic process)\tNucleus dorsooralis internus (Body Part, Organ, or Organ Component)\tStage IIB Colon Cancer (Stage II Colon Cancer AJCC v7)", + "output": "linear vestibuloocular reflex (Organism Function)" + }, + { + "input": "Definition: Medical Device described as an erythrocytic glucose-6-phosphate dehydrogenase assay is a device used to measure the activity of the enzyme glucose-6-phosphate dehydrogenase or of glucose-6-phosphate dehydrogenase isoenzymes. The results of this assay are used in the diagnosis and treatment of nonspherocytic congenital hemolytic anemia or drug-induced hemolytic anemia associated with a glucose-6-phosphate dehydrogenase deficiency. This generic device includes assays based on fluorescence, electrophoresis, methemoglobin reduction, catalase inhibition, and ultraviolet kinetics.\nConcepts: delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity (ligase activity)\tGLUCOSE-6-PHOSPHATE DEHYDROGENASE (ERYTHROCYTIC), MICROMETHOD (Medical Device)\tCRY2 gene (Genes, Regulator)\tpositive regulation of lipid storage (regulation of lipid storage)\tstoichiometry (Physical Phenomenon or Property)", + "output": "GLUCOSE-6-PHOSPHATE DEHYDROGENASE (ERYTHROCYTIC), MICROMETHOD (Medical Device)" + }, + { + "input": "Definition: 2-oxoglutarate-dependent dioxygenase activity described as catalysis of the reaction: thebaine + 2-oxoglutarate + O2 <=> neopinone + formaldehyde + succinate + carbon dioxide.\nConcepts: Sexual Traumas (Mental or Behavioral Dysfunction)\tkcs (Eye)\tthebaine 6-O-demethylase activity (Molecular Function)\tcell growth in one dimension (developmental growth involved in morphogenesis)\tdihydrolipoyllysine-residue acetyltransferase activity (catalytic activity, acting on a protein)", + "output": "thebaine 6-O-demethylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as the univalent radical OH. Hydroxyl radical is a potent oxidizing agent.\nConcepts: hydroxyl radical (Hydroxides)\tcellulose and pectin-containing cell wall loosening (Cell Function)\tinterventionDescription (ICD-9-CM)\tProliferative Bronchiolitides (Disease or Syndrome)\tcollagenous fibroma (Benign Fibroblastic Neoplasm)", + "output": "hydroxyl radical (Hydroxides)" + }, + { + "input": "Definition: something described as any series of molecular signals generated as a consequence of binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.\nConcepts: Sporothrix (Sporothrix)\t(11beta)-17-(acetyloxy)-11-(4-(dimethylamino)phenyl)-19-norpregna-4,9-diene-3,20-dione (ulipristal)\tRosa canina / dog rose (Homeopathic remedies letter R)\tcomplement component iC3b binding (Molecular Function)\tTIRAP-dependent toll-like receptor 4 signaling pathway (toll-like receptor 4 signaling pathway)", + "output": "TIRAP-dependent toll-like receptor 4 signaling pathway (toll-like receptor 4 signaling pathway)" + }, + { + "input": "Definition: Amino Acid Metabolism, Inborn Errors described as increased amount of argininosuccinate in the urine.\nConcepts: cochlear nuclei, granular lamina (Body Part, Organ, or Organ Component)\tArgininosuccinic Acid Lyase Deficiency (Urea Cycle Disorders, Inborn)\tAssess ostomy irrigation (Evaluation procedure)\tMMS205D (MMSE-2 Standard Version Functional Test Question)\tD-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2->7)-disulfide (somatostatin)", + "output": "Argininosuccinic Acid Lyase Deficiency (Urea Cycle Disorders, Inborn)" + }, + { + "input": "Definition: Organ or Tissue Function described as the progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.\nConcepts: Regional Adrenal Gland Chromaffin Tumor (Adrenal Gland Pheochromocytoma)\tcolloid cyst (Central Nervous System Cysts)\t3,3'-Iminodi-1-Propanol Dimethanesulfonate (Alkylsulfonate Compound)\tAnti-GITR Agonistic Monoclonal Antibody BMS-986156 (Anti-GITR Monoclonal Antibody)\tventral aorta development (aorta development)", + "output": "ventral aorta development (aorta development)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgical removal of the entire liver.\nConcepts: Has diabetes identity card (Finding)\tHepatectomy (Hepatectomy)\tInvestigational Drugs (Agent)\tCarbohydrate estimated intake from parenteral nutrition in 24 hours (Quantitative Concept)\tANG4 (Gene or Genome)", + "output": "Hepatectomy (Hepatectomy)" + }, + { + "input": "Definition: regulation of antigen processing and presentation described as any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen.\nConcepts: Diamond Blackfan Anemia (Congenital hypoplastic anemia)\tApalutamide/Degarelix Regimen (Regimen Used to Treat Prostate Carcinoma)\tNFATC4 gene (Transcription factor genes)\tMonocyte (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS)\tregulation of peptide antigen processing and presentation (regulation of antigen processing and presentation)", + "output": "regulation of peptide antigen processing and presentation (regulation of antigen processing and presentation)" + }, + { + "input": "Definition: Gene or Genome described as human DGKH wild-type allele is located in the vicinity of 13q14.11 and is approximately 217 kb in length. This allele, which encodes diacylglycerol kinase eta protein, is involved in second messenger signaling to promote cell growth.\nConcepts: snRNA modification guide activity (snRNA binding)\tnegative regulation of interleukin-27-mediated signaling pathway (regulation of interleukin-27-mediated signaling pathway)\tactivation of apoptotic programmed cell death of metanephric collecting duct development (positive regulation of metanephros development)\tDGKH wt Allele (DGKH gene)\ttype 1 somatostatin receptor binding (somatostatin receptor binding)", + "output": "DGKH wt Allele (DGKH gene)" + }, + { + "input": "Definition: C-SSRS Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Since Last Visit - Total number of actual attempts.\nConcepts: 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one (Benzodiazepinones)\tSecondary Study Sponsor Name (Name)\tCSS0213 (C-SSRS Since Last Visit Questionnaire Question)\tPSGD Gene Mutation (Gene Mutant)\tProtein Phosphatase 3 (Formerly 2B), Catalytic Subunit, Beta Isoform (Calcineurin A Beta) wt Allele (PPP3CB gene)", + "output": "CSS0213 (C-SSRS Since Last Visit Questionnaire Question)" + }, + { + "input": "Definition: something described as osteosclerosis affecting one or more bones of the hand.\nConcepts: Small Lymphocytic Lymphoma by Ann Arbor Stage (Small Lymphocytic Lymphoma)\tAbnormality of the humerus (Abnormality of the upper arm)\tLondon Deauville Criteria Point Scale 1 (Intellectual Product)\tIncreased bone density in hand bone (Osteosclerosis)\tANTIGENS CD 038 (ADP-ribosyl Cyclase)", + "output": "Increased bone density in hand bone (Osteosclerosis)" + }, + { + "input": "Definition: Bacteroides described as a species of Bacteroides that is a major constituent of the human GUT MICROBIOTA. It normally produces enzymes important for the digestion of vegetable matter. However, it can also cause OPPORTUNISTIC INFECTIONS that result in intra-abdominal SEPSIS; BACTEREMIA; and PERITONITIS.\nConcepts: Gatekeeping (Referral and Consultation)\tFocal impaired awareness sensory seizure with hot-cold sensations (Focal sensory seizure with hot-cold sensations)\tBacillus thetaiotaomicron (Bacterium)\tAssessing Physiological Status (Health Care Activity)\txanthine oxidation (xanthine catabolic process)", + "output": "Bacillus thetaiotaomicron (Bacterium)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Since Last Visit (C-SSRS Since Last Visit) Total number of aborted attempts.\nConcepts: ICD 10 Procedure Coding System (ActInvoiceDetailClinicalServiceCode)\tFractures, Spontaneous (Pathological fracture)\tSecondary Language Spoken (Finding)\tCutaneous Neuroendocrine Carcinoma Clinical TNM Finding v7 (Finding)\tCSS0218 (Intellectual Product)", + "output": "CSS0218 (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.\nConcepts: NuA3a histone acetyltransferase complex (Cell Component)\tup-regulation of response to tumor cell (regulation of response to tumor cell)\tgerminal center expressed transcript 2 (Gene or Genome)\tguanosine tetraphosphate biosynthesis (purine ribonucleoside bisphosphate biosynthetic process)\thypothalamus gland (Pharmacologic Substance)", + "output": "guanosine tetraphosphate biosynthesis (purine ribonucleoside bisphosphate biosynthetic process)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 9q\nConcepts: FAC049-Content With Quality of My Life (Intellectual Product)\t9q13 (Cell Component)\tMuscular subaortic stenosis (Subaortic stenosis)\tAVL02-List A Word 9 (AVLT-REY Functional Test Question)\tHaptoglobin Analyses (Protein or Enzyme Type Measurement)", + "output": "9q13 (Cell Component)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as actions performed to support integument/skin problems\nConcepts: enzymes topical hyaluronidase (generic drug products begining with the letter H)\tcontrast B.ea.B. (Therapeutic or Preventive Procedure)\tSkin breakdown control (Skin Care)\tscrape (Excision)\tCysteine-Rich Protein 61, Mouse, Homolog of Gene (Gene or Genome)", + "output": "Skin breakdown control (Skin Care)" + }, + { + "input": "Definition: Cigarette described as an Indonesian cigarette made of tobacco and cloves.\nConcepts: Homeobox Protein NK2 Homolog H (TRANSCRIPTION FACTOR)\tEscape to Nostril with or without Emission During Swallowing (Impairment of Soft Palate Elevation)\tSB-743921 (Pharmacologic Substance)\tKreteks (Manufactured Object)\tTeleological Ethics (Idea or Concept)", + "output": "Kreteks (Manufactured Object)" + }, + { + "input": "Definition: something described as human RPA3 wild-type allele is located in the vicinity of 7p21.3 and is approximately 82 kb in length. This allele, which encodes replication protein A 14 kDa protein, is involved in DNA repair, replication and recombination.\nConcepts: Appendiceal Carcinoma TNM Finding v8 (Finding)\tReplication Protein A3, 14kDa wt Allele (Gene or Genome)\tFAC06145 (FACT-BMT Version 4 Questionnaire Question)\tIVD Test Reagent/Kits, Immunoassay, Rheumatism (IVD Test Reagent/Kits, Immunoassay)\tBr. asthma (Lesion of bronchus)", + "output": "Replication Protein A3, 14kDa wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Abnormal circulating unsaturated fatty acid concentration described as a reduction in the concentration of 12-HETE in the blood circulation, a metabolite of arachidonic acid.\nConcepts: Models, Genetic (Biological Models)\tstimulus interval (Temporal Concept)\thepatic necrosis (Digestive System Necrotic Lesion)\tpurine ribonucleoside bisphosphate metabolic process (Genetic Function)\tDecreased circulating 12-HETE (Finding)", + "output": "Decreased circulating 12-HETE (Finding)" + }, + { + "input": "Definition: something described as human STC1 wild-type allele is located within 8p21-p11.2 and is approximately 13 kb in length. This allele, which encodes stanniocalcin 1 protein, plays a role in the mediation of calcium homeostasis. The gene has altered expression in hepatocellular, ovarian, and breast cancers.\nConcepts: Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v7 (Hypopharyngeal Cancer Pathologic TNM Finding v7)\toxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor (Molecular Function)\tPIP4K2B gene (Phosphoinositol Kinase Family Gene)\tSTC1 (Gene or Genome)\tWilms tumor and other childhood kidney tumors (Malignant Childhood Neoplasm)", + "output": "STC1 (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as version 3.1.2 of the CDISC Study Data Tabulation Model (SDTM) Implementation Guide.\nConcepts: SDTMIG Version 3.1.2 (Study Data Tabulation Model Implementation Guide Version)\tRapidly (Degree findings)\ttunica vaginalis testis (Testis)\tpentraxin binding (opsonin binding)\tNon-telomeric trisomy 13q (Disease or Syndrome)", + "output": "SDTMIG Version 3.1.2 (Study Data Tabulation Model Implementation Guide Version)" + }, + { + "input": "Definition: Silicates described as one of a number of fibrous magnesium and calcium silicate minerals processed for thermal insulation and fireproofing. Asbestos is considered to be an environmental carcinogen; chronic inhalation of fine asbestos dust causes pulmonary asbestosis and may induce lung neoplasms. Chronic ingestion of asbestos may induce gastrointestinal neoplasms.\nConcepts: 1p13.2 (Cell Component)\tregulation of DNA replication termination (Genetic Function)\tAsbestos (Materials)\tgeissoschizine dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tMotility Related Protein-1 Gene (Gene or Genome)", + "output": "Asbestos (Materials)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as a measurement of the interferon alpha-inducible protein 27 in a biological specimen.\nConcepts: Lactose Operon (Operon)\tInterferon Alpha-Induced Protein 27 (Laboratory Procedure)\tSpecies Subgroup (Conceptual Entity)\tPQL0201 (Intellectual Product)\tUntreated Oligodendroglioma (Childhood Oligodendroglioma)", + "output": "Interferon Alpha-Induced Protein 27 (Laboratory Procedure)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as the study of the precise nature of different mental tasks and the operations of the brain that enable them to be performed, engaging branches of psychology, computer science, philosophy, and linguistics.\nConcepts: Laser Doppler Imaging (Diagnostic Imaging)\tPQL14-Feel Tired (Intellectual Product)\tScience, Cognitive (Science)\tNegative Regulation of Cell Proliferation (Cell Proliferation)\tZygomatic Buttress (Other Anatomic Concept)", + "output": "Science, Cognitive (Science)" + }, + { + "input": "Definition: mesenchymal to epithelial transition involved in renal vesicle formation described as a transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephric renal vesicle.\nConcepts: response to imidacloprid (response to organonitrogen compound)\tAB/TL Zebrafish (Fish)\tv-MYC Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived (Avian) Gene (MYCL gene)\tREAGENTS, ANTIBODY, LEGIONELLA, DIRECT & INDIRECT FLUORESCENT (Immunologic Factor)\tmesenchymal to epithelial transition involved in metanephric renal vesicle formation (Cell Function)", + "output": "mesenchymal to epithelial transition involved in metanephric renal vesicle formation (Cell Function)" + }, + { + "input": "Definition: DNA repair protein described as DNA damage-binding protein 1 (1140 aa, ~127 kDa) is encoded by the human DDB1 gene. This protein is involved in both protein ubiquitination and DNA damage repair.\nConcepts: 10*12/litre (Nominated concentrations)\tAutologous NY-ESO-1-Melanoma-Specific CD8+ T-lymphocytes (therapeutic autologous lymphocytes)\toat cell lung cancer, recurrent (Respiratory tract small cell carcinomas)\tXPE-BF (Amino Acid, Peptide, or Protein)\tMoist Heat or Steam Sterilization (Activity)", + "output": "XPE-BF (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Biomedical Occupation or Discipline described as nursing care and techniques provided to a critically ill patient during a medical emergency or crisis; includes the nursing role in diagnostic, therapeutic, and preventive procedures for the patient in such a situation.\nConcepts: Colon Resection (Colectomy)\tSimple Tandem Repeat Polymorphism (Genetic Polymorphism)\tSIQ - TS (Intellectual Product)\tProduct containing palonosetron (Pharmacologic Substance)\tcare critical nursing (Care given by nurses)", + "output": "care critical nursing (Care given by nurses)" + }, + { + "input": "Definition: Cytochrome Reductases described as a flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. EC 1.6.2.4.\nConcepts: Ribosomal RNA Processing 15 Homolog (S. cerevisiae) wt Allele (Gene or Genome)\tCHONDROSARCOMA (Malignant Neoplasms)\tMaackia (Fabaceae)\tP450 Reductase, Cytochrome (Enzyme)\tUndifferentiated Malignant Neoplasm (Malignant Neoplasms)", + "output": "P450 Reductase, Cytochrome (Enzyme)" + }, + { + "input": "Definition: Precautionary procedure described as minimizing the potential for iatrogenic injury to the patient related to a surgical procedure\nConcepts: pyrimidine ribonucleoside diphosphate synthesis (pyrimidine ribonucleoside diphosphate metabolic process)\tmethyl-CpNpN binding (nucleotide binding)\tEuonymus americanus / strawberry bush (Organic Chemical)\tNSA01-Global Negative Symptoms Rating (Intellectual Product)\tSurgical precautions (Perioperative Care)", + "output": "Surgical precautions (Perioperative Care)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the degree of cellular differentiation in a tissue sample. EXAMPLE(S): A brain tumor could be grade 3\nConcepts: farsighted (Disorder of eye)\tcellular response to inositol (cellular response to oxygen-containing compound)\tPerformed Histopathology Differentiation Grade Code (Intellectual Product)\tmedial part of solitary nucleus (Body Part, Organ, or Organ Component)\tS100A8 complex location (protein-containing complex)", + "output": "Performed Histopathology Differentiation Grade Code (Intellectual Product)" + }, + { + "input": "Definition: Adaptor Signaling Protein Gene described as this gene plays a role in signal transduction and is putatively involved in myeloid differentiation and growth arrest.\nConcepts: telephone-based intervention (Other Intervention or Procedure)\tDEU (Germanic language)\tSAPS (Adaptor Signaling Protein Gene)\tCDGIIB (Autosomal recessive hereditary disorder)\tThin eyebrow (Aplasia/Hypoplasia of the eyebrow)", + "output": "SAPS (Adaptor Signaling Protein Gene)" + }, + { + "input": "Definition: something described as the sister of your father or mother; the wife of your uncle.\nConcepts: Micro-Electro-Mechanical Systems (Manufactured Materials)\tPlay singles tennis (Intellectual Product)\tnuclear mRNA 5'-splice site recognition (Genetic Function)\taunt (Relative)\tB-lymphocyte proliferation (lymphocyte proliferation)", + "output": "aunt (Relative)" + }, + { + "input": "Definition: protein-containing complex described as a protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand.\nConcepts: MCM8 gene (Helicase Gene)\tproepicardium development (mesenchyme development)\tLow Absorption Reticulocytes (Laboratory Procedure)\tIVD Test Reagent/Kits, Home Assay, Whole Blood, Glucose (Medical Device)\tmacrophage colony-stimulating factor:receptor complex (Cell Component)", + "output": "macrophage colony-stimulating factor:receptor complex (Cell Component)" + }, + { + "input": "Definition: Suboptimal Image Reason described as an artifact resulting from movement of the object being imaged during the imaging sequence.\nConcepts: Hygromycin B (generic drug products begining with the letter H)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, N-Acetylprocainamide (Medical Device)\tBrodmann area 49 (Segment of gyrus of limbic lobe)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, HIV-2, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Retrovirus, HIV-2)\tMotion Related Artifact (Finding)", + "output": "Motion Related Artifact (Finding)" + }, + { + "input": "Definition: Arthropathies NEC described as inflammation of the SACROILIAC JOINT. It is characterized by lower back pain, especially upon walking, fever, UVEITIS; PSORIASIS; and decreased range of motion. Many factors are associated with and cause sacroiliitis including infection; injury to spine, lower back, and pelvis; DEGENERATIVE ARTHRITIS; and pregnancy.\nConcepts: Vitamin K modified diet (Modified vitamin diet)\tLISTERIA WELSHIMERI (Listeria)\tObserved Medical Device Type In Intended Location (Finding)\tinflammation joint sacroiliac (Spinal Diseases)\tFAC00837 (FACT-C Version 4 Questionnaire Question)", + "output": "inflammation joint sacroiliac (Spinal Diseases)" + }, + { + "input": "Definition: Gene or Genome described as human CLTCL1 wild-type allele is located in the vicinity of 22q11.2 and is approximately 112 kb in length. This allele, which encodes clathrin heavy chain 2 protein, plays a role in receptor-mediated endocytosis and cellular vesicle transport. Chromosomal aberrations involving this gene are associated with meningioma, DiGeorge syndrome, and velo-cardio-facial syndrome.\nConcepts: Clathrin, Heavy Polypeptide-Like 1 Gene (Gene or Genome)\t(-)-modafinil (Pharmacologic Substance)\tBeta-N-acetyl-D-glucosaminidase (Laboratory Procedure)\tB-cell translocation gene 1, anti-proliferative (Gene or Genome)\tPhenocopy (Miscellaneous Molecular Biology Terms)", + "output": "Clathrin, Heavy Polypeptide-Like 1 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as presentations of data in tabular form.\nConcepts: tetanus toxoid helper peptide (Pharmacologic Substance)\tCommands (ADAS-Cog CDISC Version Questionnaire Question)\tBrucella melitensis biovar abortus (Brucella species)\tHigh blood aspartic acid levels (Abnormal circulating aspartic acid concentration)\tTable (Conceptual Entity)", + "output": "Table (Conceptual Entity)" + }, + { + "input": "Definition: Health Care Related Organization described as a national clinical research group - network of 29 university medical centers, over 185 community hospitals and more than almost 3000 physicians - sponsored by the NCI, with its Central Office headquartered at the University of Chicago, and its Statistical Center located at Duke University, founded in 1955 with a goal of bringing together clinical and laboratory research.\nConcepts: CDISC ADAS-Cog - Word Recognition: Word 3 (ADAS-Cog CDISC Version Questionnaire Question)\tRegular Dense Connective Tissue (soft tissue)\tCALGB (Health Care Related Organization)\tfibroblast growth factor 6 protein, human (Fibroblast Growth Factor)\tThe PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails (Cell Function)", + "output": "CALGB (Health Care Related Organization)" + }, + { + "input": "Definition: something described as mental retardation associated with psoriasis and seizures.\nConcepts: X-linked mental retardation-psoriasis syndrome (Disease or Syndrome)\tDenture Base Resins, Heat-Cured (Dental Materials, Manufacture/Repair, Denture Base Resin)\tSuspension Culture (Cell Culture)\tSmall Cell Adenocarcinoma (Neoplastic Process)\tGenus Myroides (Non-fermentative Gram-negative bacillus)", + "output": "X-linked mental retardation-psoriasis syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as this gene plays a role in the synthesis of proteins.\nConcepts: regulation of epinephrine import (regulation of transport)\tEEF1D gene (Protein Complex Subunit Gene)\tTemporary Partial Dentures (Medical Device)\tLaboratory Hoods, Laminar Flow, Horizontal (Laminar airflow hood)\tSelf-Awareness (Mental Process)", + "output": "EEF1D gene (Protein Complex Subunit Gene)" + }, + { + "input": "Definition: Regulatory Pathway described as covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the protein modifiers. Recently a new group of ubiquitin-like (Ubl) proteins have come to light. One of the most intriguing of them is SUMO (small ubiquitin-like modifier, 12kDa) also known as Sentrin. SUMO family has been described in vertebrates: SUMO-1 and the closest homologs SUMO-2 and SUMO-3. SUMO have been shown to bind and regulate mammalian SP-RINGs (such as Mdm2, PIAS and PML), RanGAP1, RanBP2, p53, p73, HIPK2, TEL, c-Jun, CtBP, Fas, Daxx, TNFRI, Topo-I, Topo-II, WRN, Sp100, IkB-alpha, Androgen receptor (AR), GLUT1/4, Drosophila Ttk69, Dorsal, CaMK, yeast Septins, and viral CMV-IE1/2, EBV-BZLF1, HPV/BPV-E1. In the case of the transcription co-repressor CtBP, which can be recruited to the target promoter via interaction with a conserved PxDLS motif in the interacting repressor, CtBP SUMOylation profoundly affected its subcellular localization. SUMOylation occurred at a single Lys residue, Lys428, of CtBP1. Mutating Lys428 into Arg (K428R) shifted CtBP1 from the nucleus to the cytoplasm, while it had little effect on its interaction with the PxDLS motif. The K428R mutation also abolished the ability of CtBP1 to repress the E-cadherin promoter activity. Consistent with the known inhibitory effect of nNOS on the nuclear accumulation of CtBP1, PDZ domain of nNOS inhibits the SUMOylation of CtBP1. The current data indicates that SUMOylation can regulate CtBP1-dependent transcriptional repression.\nConcepts: Maternal Deprivations (Family Relationship)\tOvarian Yolk Sac Tumor, Polyvesicular Vitelline Pattern (Neoplastic Process)\tBDKRB1 Measurement (Laboratory Procedure)\tAtypical small acinar proliferation of prostate (Benign Neoplasm)\tSUMOylation as a mechanism to modulate CtBP-dependent gene responses (Molecular Function)", + "output": "SUMOylation as a mechanism to modulate CtBP-dependent gene responses (Molecular Function)" + }, + { + "input": "Definition: Degenerative disorder of eye described as partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence).\nConcepts: Thrombocyte Differentiation (Myeloid Cell Differentiation)\tIVD Test Reagent/Kits, Microbiology, Control, Fungi/Yeast Test (IVD Test Reagent/Kits, Microbiology, Control)\tregulation of division septum formation involved in mitotic cell cycle (Cell Function)\tNEPHROPATHY, SICKLE CELL (Disease or Syndrome)\tcataract (Other cataract)", + "output": "cataract (Other cataract)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate.\nConcepts: Abnormality of umbilical vein blood flow (Abnormality of the fetal cardiovascular system)\taldehyde oxygenase (deformylating) activity (carbon-carbon lyase activity)\tphosphopentomutase activity (intramolecular transferase, phosphotransferases activity)\tcollagen binding (Molecular Function)\tBug, Assassin (Reduvioidea)", + "output": "phosphopentomutase activity (intramolecular transferase, phosphotransferases activity)" + }, + { + "input": "Definition: Benzoflavones described as a polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)\nConcepts: Clinical COPD Questionnaire 1 Week Version Questionnaire Test Code (CDISC Questionnaire Terminology)\tTranscendental meditation (Mental Process)\t3-Phenyl-1H-naphtho[2,1-b]pyran-1-one (Pharmacologic Substance)\tacetyl-CoA:CoA antiporter activity (anion:anion antiporter activity)\tOABQ01-Stay Home More Often Than Prefer (OAB-q Questionnaire Question)", + "output": "3-Phenyl-1H-naphtho[2,1-b]pyran-1-one (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as testing of cell bank specimens for microbial contamination.\nConcepts: Flattened metacarpal heads (Abnormal metacarpal morphology)\tcarbons (Inorganic carbon)\tAMIKACIN SERUM ASSAY (Medical Device)\tLaboratory Testing, Working Cell Bank Release Testing (Microbiology procedure)\tORC (Cell Component)", + "output": "Laboratory Testing, Working Cell Bank Release Testing (Microbiology procedure)" + }, + { + "input": "Definition: Cranial cavity structure described as the infratentorial compartment of the cranial cavity. Its boundaries are formed by the sphenoid bone, temporal bone, and parietal bone, and it contains the cerebellum and brain stem.\nConcepts: Human leukocyte antigen (HLA) typing of antigen DR (HLA Typing)\tadenomatous polyposis coli of large intestine (Hereditary Diseases)\tcytochrome b6-f complex (cytochrome complex)\tFossa cranii posterior (Cranial cavity structure)\tEomesodermin wt Allele (Gene or Genome)", + "output": "Fossa cranii posterior (Cranial cavity structure)" + }, + { + "input": "Definition: Antifungal Agents described as a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals.\nConcepts: COX-2 inhibitor (Pharmacologic Substance)\ttraumatic amputations (injuries or accidents)\tIrregular proximal femoral epiphyses (Anatomical Abnormality)\tELECTROPHORETIC, PROTEIN FRACTIONATION (Medical Device)\tTrichostatin A (Organic Chemical)", + "output": "Trichostatin A (Organic Chemical)" + }, + { + "input": "Definition: Organic Chemical described as a viscous, hygroscopic amino alcohol with an ammoniacal odor. It is widely distributed in biological tissue and is a component of lecithin. It is used as a surfactant, fluorimetric reagent, and to remove CO2 and H2S from natural gas and other gases.\nConcepts: AMINOETHANOL 02 (Acylglycine)\tAIMS01-Upper Extremities (AIMS Clinical Classification Question)\tTherapies, Combined Modality (Therapeutic procedure)\tPQL1201 (Intellectual Product)\t9-((2-Hydroxyethoxy)methyl)guanine Monosodium Salt (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "AMINOETHANOL 02 (Acylglycine)" + }, + { + "input": "Definition: something described as auditory Verbal Learning Test Version A - List A, Recall 3, Word 9.\nConcepts: ADNI AVLT - List A Recall 3 Word 9 (Intellectual Product)\tMay-Hegglin Anomaly (Hereditary thrombocytopenic disorder)\tprolonged; delivery, second stage (Pathologic Function)\tPLEKHE1 (Gene or Genome)\tMalignant Gastric Germ Cell Tumor (Gastric Germ Cell Tumor)", + "output": "ADNI AVLT - List A Recall 3 Word 9 (Intellectual Product)" + }, + { + "input": "Definition: Abnormality of glycoside metabolism described as abnormality of galactoside metabolism. A galactoside is a glycoside (a suger moiety bound to some other moiety) containing galactose.\nConcepts: Stage III Thymic Epithelial Neoplasm AJCC v8 (Thymic Epithelial Neoplasm by AJCC v8 Stage)\tHigh Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant (High-Grade Prostatic Intraepithelial Neoplasia)\tRight Ventricular Ejection Fraction, Calculated (Finding)\tStaphylococcus gallinarum Devriese et al. 1983 (Genus staphylococcus)\tAbnormality of galactoside metabolism (Finding)", + "output": "Abnormality of galactoside metabolism (Finding)" + }, + { + "input": "Definition: Miscellaneous substance administration described as administering a chelating substance to a client/patient through a muscle for therapeutic effect(s) (for example, to bind and eliminate detrimental materials in the blood). Service is billed per treatment.\nConcepts: Orbital Sarcoma Pathologic Regional Lymph Nodes TNM Finding v8 (Orbital Sarcoma Pathologic TNM Finding v8)\tPenile Cancer cNX TNM Finding v7 (Finding)\tProxemics (Individual Behavior)\tIM chel therp admin.ea.Tx (Therapeutic or Preventive Procedure)\tnegative regulation of arginine catabolic process by transcription from RNA polymerase II promoter (Genetic Function)", + "output": "IM chel therp admin.ea.Tx (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Manufactured Object described as a part of a device designed to stabilize or support the hand.\nConcepts: Glaucarubin (Quassins)\tpositive regulation of extracellular matrix disassembly (regulation of extracellular matrix disassembly)\tAnti-GM2 Monoclonal Antibody BIW-8962 (Monoclonal Antibodies)\tNHMCELE (Laboratory Procedure)\tHandrest (Device Component or Accessory)", + "output": "Handrest (Device Component or Accessory)" + }, + { + "input": "Definition: Molecular Function described as the regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus.\nConcepts: Free and Sovereign State of Zacatecas (Mexican State)\tadaptation of signalling pathway (Molecular Function)\t3p24 (Cell Component)\taccess to health care (Family health status)\tperforant pathway (fornix system)", + "output": "adaptation of signalling pathway (Molecular Function)" + }, + { + "input": "Definition: something described as trocars designed to puncture the abdominal wall in order to provide access to the gallbladder. These instruments typically consist of a manual, handheld device with a sharp pyramidal or conical strong and solid pointed rod and a proximal large handle. Gallbladder trocars are usually fitted into a cannula, or sleeve; the trocar is used to pierce the skin and the abdominal wall (i.e., percutaneously) reaching the gallbladder and then removed, leaving the cannula and the aspiration tube in place. The cannula usually includes a lateral secondary tube (e.g., Ochsner trocar) for external aspiration. Gallbladder trocars are intended to provide access to the gall bladder, permit the aspiration of fluids, and/or to instill medications or solutions. They are used for diagnostic procedures or to empty an enlarged bladder prior to surgery.\nConcepts: IVD Test Reagent/Kits, Microbiology, Control, Culture Media (Medical Device)\tTrocars, Abdominal, Gallbladder (Medical Device)\tSestamibi Scan (Radionuclide Imaging)\tPapio, NOS (Mammal)\tEpilepsy, Lateral Temporal Lobe, Autosomal Dominant (Epilepsy, Temporal Lobe)", + "output": "Trocars, Abdominal, Gallbladder (Medical Device)" + }, + { + "input": "Definition: INFLAMMATIONS: GENERAL TERMS described as pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions; usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.\nConcepts: Hippocampus Regio Superior (Segment of hippocampus proper)\tCatheters, Cardiac, Angiography, High-Flow (Medical Device)\tstorageSOPClassesInStudy (Identifier)\tHeart Sarcoma (Malignant neoplasm of heart)\tInflammation, NOS (Inflammatory morphology)", + "output": "Inflammation, NOS (Inflammatory morphology)" + }, + { + "input": "Definition: Operations on urinary bladder described as surgical creation of an opening (stoma) in the URINARY BLADDER for drainage.\nConcepts: vesicostomy (Cystostomy)\tQARC (Clinical or Research Facility)\tMagnifier Device (Device Component or Accessory)\tFrullania (Plant)\tCervical Adenocarcinoma Admixed with Neuroendocrine Carcinoma (Cervical Adenocarcinoma)", + "output": "vesicostomy (Cystostomy)" + }, + { + "input": "Definition: negative regulation of steroid metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids.\nConcepts: negative regulation of ecdysteroid metabolic process (negative regulation of cellular metabolic process)\tPedsQL Neuromuscular Module Acute Version 3.0 Young Child Report - Hands Are Weak (Intellectual Product)\tUK - United Kingdom of Great Britain and Northern Ireland (Western Europe)\tFebrile status epilepticus (Status Epilepticus)\tHepadnaviridae (Enveloped dsDNA virus)", + "output": "negative regulation of ecdysteroid metabolic process (negative regulation of cellular metabolic process)" + }, + { + "input": "Definition: Peptide Hormone Gene described as this gene plays a role in endoderm differentiation, heart development and angiogenesis.\nConcepts: negative regulation of eosinophil chemotaxis (Cell Function)\tendocrine; disorder hypertension (Endocrine and metabolic secondary hypertension)\tVaccines, Pneumococcal (Pharmacologic Substance)\tInhibitors, Acetylcholinesterase (Substance with effector mechanism of action)\tAPELA Gene (Peptide Hormone Gene)", + "output": "APELA Gene (Peptide Hormone Gene)" + }, + { + "input": "Definition: Bone Cancer Clinical Distant Metastasis TNM Finding v7 described as bone cancer without evidence of distant metastasis.\nConcepts: RP (Idea or Concept)\tTesting of Raw/Starting Materials (Functional Concept)\tIL-1 alpha production (interleukin-1 production)\tBone Cancer cM0 TNM Finding v7 (Finding)\tPure red cell anaemia (Erythropenia)", + "output": "Bone Cancer cM0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Lasers described as gas lasers with argon ion, as the active medium. Their principal emission wavelengths are 488 and 514 nm (blue-green). These lasers are operated in continuous-wave mode.\nConcepts: Image, Body (Comfort Status: Psychospiritual)\tCDK1/2/4 Inhibitor AG-024322 (Pharmacologic Substance)\tCOLUMNS, GLC (Medical Device)\tArgon Lasers (Medical Device)\tvasovasostomy (Anastomosis - action)", + "output": "Argon Lasers (Medical Device)" + }, + { + "input": "Definition: Psychology described as branch of psychology concerned with the emotional, attitudinal, social, and intellectual changes in an individual between birth and death.\nConcepts: Supraglottic Cancer pN2a TNM Finding (Supraglottic Cancer pN2 TNM Finding v7)\tHaematoxylon campechianum / kampeche / logwood (Pharmacologic Substance)\tcitramalate CoA-transferase activity (Molecular Function)\tdevelopmental psychology (Biomedical Occupation or Discipline)\tprolymphocytes (Nongranular leukocyte)", + "output": "developmental psychology (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Cell Component described as a complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.\nConcepts: v-raf Murine Sarcoma Viral Oncogene Homolog B1 Gene Amplification (Gene Amplification Abnormality)\tSocial role (Generic Role)\tBLASTLE (Laboratory Procedure)\tT6SS complex location (Cell Component)\tblocks sympathetic (Sympathetic nerve or ganglion block)", + "output": "T6SS complex location (Cell Component)" + }, + { + "input": "Definition: Cerebral Palsy described as a subtype of non-spastic cerebral palsy with loss of muscular coordination with abnormal force and rhythm, and impairment of accuracy; commonly presents with gait and trunk ataxia, poor balance, past pointing, terminal intention tremor, scanning speech, nystagmus and other abnormal eye movements, and hypotonia. Low tone is a prominent feature.\nConcepts: Anti-Coagulation Factor Xa Unit (Anti-Coagulation Factor Unit)\tThoracic Surgical Oncologist (Biomedical Occupation or Discipline)\tup-regulation of invadopodium disassembly (positive regulation of cell projection organization)\tPGL (SDHD gene)\tACP (Little's Disease)", + "output": "ACP (Little's Disease)" + }, + { + "input": "Definition: Professional or Occupational Group described as education students or graduates prior to employment as teachers.\nConcepts: Metastatic Neoplasm to the Parathyroid (Parathyroid Diseases)\tSIQ02-I Wished I Were Dead (Intellectual Product)\trhabdomere microvillus (Cell Component)\tPreservice Teachers (Teacher)\tregulation of systemic arterial blood pressure by neurotransmitter (Molecular Function)", + "output": "Preservice Teachers (Teacher)" + }, + { + "input": "Definition: Neoplastic Process described as a mesenchymal neoplasm that arises from the bladder.\nConcepts: Bladder Soft Tissue Neoplasm (Neoplastic Process)\tPaget Disease of the Breast without Invasive Carcinoma (Paget's Disease, Mammary)\tTotal iron binding capacity (Nutritional status: biochemical measures)\tUltrasound Scanners, Mammography (Scanning Systems, Ultrasonic)\tCDK3 Gene (Cyclin-Dependent Kinase Gene)", + "output": "Bladder Soft Tissue Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: EQ-5D-3L Questionnaire Question described as the EuroQol (European Quality of Life) Five Dimension Three Level Scale (EQ-5D-3L) Indicate which statements best describe your own health state today: Anxiety or depression.\nConcepts: Failure, Renal (kidney functional)\tEQ5D0105 (EQ-5D-3L Questionnaire Question)\tVomiting or Dry Heaves Affected Sleep During Past 24 Hours (Findings-Based Question)\tHas concentration strength denominator unit (Intellectual Product)\tprejudices (Judgment)", + "output": "EQ5D0105 (EQ-5D-3L Questionnaire Question)" + }, + { + "input": "Definition: Stippling of the epiphyses of the hallux described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the distal phalanx of the hallux.\nConcepts: CSPRMSEV (Finding)\tsulphur oxygenase/reductase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tlymphadenopathy (WHITE CELL AND RES DISORDERS)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, TBP Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG)\tSpeckled calcifications in the end part of the outermost bone of the big toe (Anatomical Abnormality)", + "output": "Speckled calcifications in the end part of the outermost bone of the big toe (Anatomical Abnormality)" + }, + { + "input": "Definition: Brazilian State described as a state in the Northeast Region of Brazil. Its capital is Joao Pessoa.\nConcepts: Epidermal Growth Factor Receptor L861R (EGFR Protein Variant)\tInsulin antibodies (Insulin)\tpeptidyl-aspartic acid phosphorylation (Protein phosphorylation)\tParaiba (Brazilian State)\tHemophagocytic Lymphohistiocytoses (Immune and associated conditions NEC)", + "output": "Paraiba (Brazilian State)" + }, + { + "input": "Definition: Aminoglycoside antibacterial product described as a broad-spectrum aminoglycoside antibiotic produced by fermentation of Micromonospora purpurea or M. echinospora. Gentamicin is an antibiotic complex consisting of four major (C1, C1a, C2, and C2a) and several minor components. This agent irreversibly binds to the bacterial 30S ribosomal subunit. Specifically, this antibiotic is lodged between 16S rRNA and S12 protein within the 30S subunit. This leads to interference with translational initiation complex, misreading of mRNA, thereby hampering protein synthesis and resulting in bactericidal effect. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.\nConcepts: male germ cell nucleus (germ cell nucleus)\tpleomorphicadenoma of the salivary gland gene like 1 protein, human (TRANSCRIPTION FACTOR)\tGuards, Mouth (Medical Device)\tcentral canal development (Organ or Tissue Function)\tGentamicin product (Drug allergens)", + "output": "Gentamicin product (Drug allergens)" + }, + { + "input": "Definition: something described as catalysis of the reaction: alpha-D-galactose 1-phosphate + dTTP = diphosphate + dTDP-D-galactose.\nConcepts: thymidine diphosphogalactose pyrophosphorylase activity (Molecular Function)\tMAGE-C1 Positive (Positive Laboratory Test Result)\tRound Epithelial Cell Count (Laboratory Procedure)\tExtent of Painful Throat (Clinical or Research Assessment Question)\tHg - Mercury (Transition Elements)", + "output": "thymidine diphosphogalactose pyrophosphorylase activity (Molecular Function)" + }, + { + "input": "Definition: something described as food is soft, tender and moist. Needs some chewing. Can be mashed with a fork. No seeds, skins, husks, skin, or hard chunks. No sticky, tough, chewy, crunchy or leafy foods. Mashed easily using a fork at the point of consumption (Source: Academy of Nutrition and Dietetics Nutrition Informatics Committee 2013).\nConcepts: Abbreviated New Animal Drug Application (Intellectual Product)\tnegative regulation of insulin secretion (Cell Function)\tFork-mashable food (Soft food)\tNPS01-Describe Time Quality Of Your Pain (NPS Questionnaire Question)\tVon Kupffer cell (Cell)", + "output": "Fork-mashable food (Soft food)" + }, + { + "input": "Definition: xylem development described as the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed.\nConcepts: Medical Events of Interest (Intellectual Product)\tmetaxylem development (Organ or Tissue Function)\tdown regulation of telomere maintenance via semi-conservative replication (regulation of telomere maintenance via semi-conservative replication)\tdown regulation of retroviral genome replication (Genetic Function)\tETV6-JAK2 Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "metaxylem development (Organ or Tissue Function)" + }, + { + "input": "Definition: Biologically Active Substance described as mothers against decapentaplegic homolog 7 (426 aa, ~46 kDa) is encoded by the human SMAD7 gene. This protein plays a role in the attenuation of transforming growth factor-beta type-1 receptor signal transduction.\nConcepts: Argonaute 4, RISC Catalytic Component Gene (Gene or Genome)\tIdic(15) (Anomaly of chromosome pair 15)\tSpoon thick liquid (Fluid consistency type)\tInhibition, Prepulse (Thesaurus of Psychological Index Terms)\tMothers Against Decapentaplegic Homolog 7 (Amino Acid, Peptide, or Protein)", + "output": "Mothers Against Decapentaplegic Homolog 7 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: regulation of cytokine biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of TRAIL, TNF-related apoptosis inducing ligand.\nConcepts: regulation of TRAIL biosynthesis (regulation of TRAIL production)\tGERM CELL NEOPL (Neoplastic disease)\tMDM2/MDMX inhibitor ALRN-6924 (MDM2 Inhibitor)\tPeriodic Acid-Schiff Positive (Laboratory or Test Result)\tTransglutaminase 7 Gene (Gene or Genome)", + "output": "regulation of TRAIL biosynthesis (regulation of TRAIL production)" + }, + { + "input": "Definition: Intellectual Product described as paced Tapping - The standard deviation of the intertap intervals within the tone-tapping phase of Trial n.\nConcepts: regulation of type III site-specific deoxyribonuclease activity (Genetic Function)\tLug Metal Container Closure (Container Closure System)\tGSE - Gluten-sensitive enteropathy (Disorder of small intestine)\tPTAP1-Deviation Interval Tone Trial (Paced Tapping Functional Test Question)\tMacroamylase (Amylase measurement)", + "output": "PTAP1-Deviation Interval Tone Trial (Paced Tapping Functional Test Question)" + }, + { + "input": "Definition: something described as a biospecimen collection and staining procedure in which maternal blood smear is prepared and stained using Shepard's staining method, followed by microscopic examination to identify fetal-maternal hemorrhage (fetal hemoglobin transference to the mother's bloodstream).\nConcepts: Absent Fetal Heart Rate Variability (Fetal heart rate variability - finding)\tup regulation of contractile ring assembly involved in mitotic cytokinesis (positive regulation of cytokinesis, actomyosin contractile ring assembly)\tpersumac powder (Antiemetics)\tKleihauer-Betke (Laboratory Procedure)\t21U-RNA binding (RNA Binding)", + "output": "Kleihauer-Betke (Laboratory Procedure)" + }, + { + "input": "Definition: Abnormal CSF protein level described as CSF total protein level is below the lower limit of normal.\nConcepts: Recorders, Electronic Storage, Data, Electrocardiography, Continuous (Electrocardiographs, Ambulatory)\tCerebrospinal fluid protein decreased (Cerebrospinal fluid tests)\tIal (orbito-insular area)\tRecurrent Fallopian Tube Endometrioid Adenocarcinoma (Endometrioid adenocarcinoma recurrent)\tBoswellia serrata resin oil (Natural Products)", + "output": "Cerebrospinal fluid protein decreased (Cerebrospinal fluid tests)" + }, + { + "input": "Definition: Sodium, potassium AND/OR calcium diet described as a diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states.\nConcepts: ALBUMIN,IODINATED I-131 SERUM (Radioisotopic compound for diagnosis AND/OR treatment)\tReduced sodium diet (Sodium modified diet)\tPEG-interleukin-2 (Recombinant Interleukin-2)\tVulvar Adenocarcinoma of Sweat Gland Type (Neoplastic Process)\tBelly Button (Subdivision of front of abdomen)", + "output": "Reduced sodium diet (Sodium modified diet)" + }, + { + "input": "Definition: something described as interpreting a client/patient's neuropsychological test(s). Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.\nConcepts: The Department of Oncology of the University of Wisconsin-Madison (Professional Organization or Group)\tNeuropsychological test interpretation each 15 minutes (Mental health testing and/or interpretation)\tPedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Feel Tired (Intellectual Product)\tChart completion by medical records (Health Care Activity)\tEpithelioid Hemangioma of Breast (Histiocytoid hemangioma)", + "output": "Neuropsychological test interpretation each 15 minutes (Mental health testing and/or interpretation)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane.\nConcepts: CTS binding (signal sequence binding)\tProtocol Defined Response Criteria (Idea or Concept)\tMembrane Transport Modulators (Pharmacologic Substance)\tGerman Cockroach IgG AB RAST Score (Immunoglobulin G measurement)\tStage III Gallbladder Carcinoma AJCC v7 (Neoplastic Process)", + "output": "CTS binding (signal sequence binding)" + }, + { + "input": "Definition: Metastatic Malignant Female Reproductive System Neoplasm described as a carcinoma that arises from the fallopian tube and has metastasized to another anatomic site.\nConcepts: GTP:GDP antiporter activity (guanine nucleotide transmembrane transporter activity)\tMetastatic Fallopian Tube Carcinoma (Metastatic Genitourinary System Carcinoma)\tAdjustment, Occlusal (Dental Procedures)\tAbnormality of olfaction (Finding)\tPenile Squamous Cell Carcinoma Pathologic Distant Metastasis TNM Finding v8 (Penile Cancer Pathologic TNM Finding v8)", + "output": "Metastatic Fallopian Tube Carcinoma (Metastatic Genitourinary System Carcinoma)" + }, + { + "input": "Definition: something described as a unit expressed as one liter of volume per unit of time equal to one hour per square meter of area.\nConcepts: flavin adenine dinucleotide synthesis (Molecular Function)\tLiter Per Hour Per Square Meter (Quantitative Concept)\tStratum papillare (Skin)\tpositive regulation of (R)-mevalonic acid biosynthetic process (Molecular Function)\tHepadnaviridae (Virus)", + "output": "Liter Per Hour Per Square Meter (Quantitative Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as duplication of the long arm of chromosome 1 with growth and mental deficiency, microcephaly, highly arched cleft palate, facial abnormalities, and brachydactyly.\nConcepts: cardiac fibroblast cell fate commitment (cardiac cell fate commitment)\tMedical Chart Filing Cabinets (Manufactured Object)\t1p trisomy (Disease or Syndrome)\tADCS-ADL MCI - Perform Pastime, Hobby or Game: Card or Board Games (Intellectual Product)\targinine catabolic process to proline (arginine catabolic process)", + "output": "1p trisomy (Disease or Syndrome)" + }, + { + "input": "Definition: Abnormal Cardiac Study described as an ambulatory electrocardiographic technique that records a continuous electrocardiographic rhythm pattern for greater than or equal to 24 h to detect heart arrhythmias.\nConcepts: glyceride acyl-chain remodeling (acylglycerol metabolic process)\tInjuries, Head (Other and unspecified injuries of head)\tregulation of metanephros development (regulation of kidney development)\tAbnormal Holter Monitoring Finding (Abnormal Cardiac Study)\tShoulder Somatic Dysfunction (Finding)", + "output": "Abnormal Holter Monitoring Finding (Abnormal Cardiac Study)" + }, + { + "input": "Definition: Finding described as higher intake of iodine compared to established reference standards or recommendations based on physiological needs (Source: International Dietetics and Nutrition Terminology (IDNT) Reference Manual, edition 4; ISBN #978-0-88091-467-3)\nConcepts: Embryonal Carcinoma of the Testis (Embryonal Carcinoma)\tMyeloid to Erythroid Ratio Measurement (Laboratory Procedure)\tExcessive iodine intake (Excessive mineral intake)\talcohol; Laennec (Disease or Syndrome)\tExocrine Pancreas (Intra-abdominal digestive structure)", + "output": "Excessive iodine intake (Excessive mineral intake)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Pediatric/Cognitively Impaired Lifetime/Recent (C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent) Description of wishing to be dead.\nConcepts: Rotavirus A RNA Measurement (Microbiology procedure)\tProteins, Drosophila (Non-Human Protein)\tECENDY (Observation End Day)\tCSS1001C (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)\tHepatocellular Carcinoma pN0 TNM Finding v8 (Finding)", + "output": "CSS1001C (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as the determination of the amount of cytokeratin 16 present in a sample.\nConcepts: CY16 (Laboratory Procedure)\tHepatic plate (Liver parenchyma)\tAbsent septum pellucidum (Congenital disease of brain)\tProphylactic Mastectomy Patient (Patient or Disabled Group)\tMedulla oblongata fasciculus cuneatus (Fasciculus of brain)", + "output": "CY16 (Laboratory Procedure)" + }, + { + "input": "Definition: protein-containing complex described as a protein complex acting as ligand of the transforming growth factor beta receptor complex, typically a homodimer of any of the TFGbeta isoforms. The precursor of TGFbeta proteins is cleaved into mature TGFbeta and the latency-associated peptide (LAP), which remains non-covalently linked to mature TGFbeta rendering it inactive. TGFbeta is activated by dimerisation and dissociation of the LAP.\nConcepts: TGFbeta complex location (protein-containing complex)\tANTIGENS, ALL GROUPS, STREPTOCOCCUS SPP. (Indicator, Reagent, or Diagnostic Aid)\tTags, Emergency Controlled Access (Medical Device)\ttreatment-emergent adverse event (Adverse Event by Type)\tLactobacillus-based capsule (Dietary Supplements)", + "output": "TGFbeta complex location (protein-containing complex)" + }, + { + "input": "Definition: something described as actions performed to flush or wash out the artificial opening that removes bowel waste products\nConcepts: Bowel Ostomy Irrigation (Bowel Ostomy Care)\tLocalized Hemorrhagic and Ulcerated Lesion (Localized Lesion)\tHepatoblastoma, Resectable (Hepatoblastoma)\tIncreased width of columella (Abnormality of the columella)\tC-terminal peptidyl-arginine amidation (peptidyl-arginine modification)", + "output": "Bowel Ostomy Irrigation (Bowel Ostomy Care)" + }, + { + "input": "Definition: Biologic Function described as the process whose specific outcome is the progression of a shoot apical meristem over time, from its formation to the mature structure.\nConcepts: NEC (Rate)\tshoot apical meristem development (meristem development)\tTobacco Use and Related Risk Factors, Surveillance (Research Activity)\tLENS, CONTACT (Rigid contact lens)\tSalmonella Serotype Choleraesuis (Salmonella enterica subsp. enterica)", + "output": "shoot apical meristem development (meristem development)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate <=> (+)-beta-chamigrene + diphosphoric acid.\nConcepts: Meningitides, Listeria (Disease or Syndrome)\tVEGFA wt Allele (Gene or Genome)\tDelayed Alternation (Mental Process)\tPrior Invasive Malignancy (Finding)\t(+)-beta-chamigrene synthase activity (Molecular Function)", + "output": "(+)-beta-chamigrene synthase activity (Molecular Function)" + }, + { + "input": "Definition: Molecular Function described as in glycolysis, the six-carbon sugar glucose is oxidized and split in two halves, to create two molecules of pyruvate (3 carbons each) from each molecule of glucose. Along the way, the cell extracts a relatively small amount of energy from glucose in the form of ATP, 2 ATP molecules collected for each glucose molecule that starts down the glycolytic path. The pyruvate produced has one of three metabolic fates, to either become acetyl-CoA, ethanol, or lactate. When oxygen is available, the pyruvate can be converted to acetyl-CoA and enter the Krebs Cycle, where the acetyl-CoA will be completely oxidized and generate ATP through oxidative phosphorylation. Fermentation is much less efficient than oxidative phosphorylation in making ATP, creating only 2 ATP per glucose while oxidative phosphorylation creates 36 ATP per glucose in mammalian cells. Oxidative phosphorylation does not work in the absence of oxygen, however, and in the absence of oxygen glycolysis is forced to a halt due to a lack of NAD+, unless NAD+ is regenerated through fermentation. In mammalian muscle, strenuous exertion can create conditions in which oxygen is consumed faster than blood can provide it, forcing the muscle to use fermentation and create lactic acid; it is the lactic acid that makes your muscles sore after a workout. There are ten enzymes that catalyze the steps in glycolysis that convert glucose into pyruvate, and the entire pathway is located in the cytoplasm of eukaryotic cells. The activity of the pathway is regulated at key steps to ensure that glucose consumption and energy production match the needs of the cell. The steps along the pathway each involve a change in the free energy of the products and reactants, and as long as the overall change in free energy is negative, the reaction continues forward, like water flowing down hill to its lowest energy point. The key steps in the regulation of glycolysis, or any pathway, are those that catalyze the rate-limiting, irreversible steps along the pathway. In glycolysis in mammals, the key regulatory enzyme is phosphofructokinase, which catalyzes the rate-limiting committed step. Phosphofructokinase is activated by AMP and inhibited by ATP, among other regulatory mechanisms. Thus, when ATP is low (and AMP is high), phosphofructokinase will be activated and generate more ATP. Similarly, when ATP is abundant, phosphofructokinase will be inhibited to prevent wasting glucose on making energy when it is not needed. Failure to provide energy can have lethal consequences for cells - the absence of oxygen caused by a stroke or a heart attack that prevents ATP generation can have lethal consequences for the cells involved. Cancer cells often generate energy through glycolytic fermentation more than oxidative phosphorylation, suggesting that manipulation of metabolism may provide a therapeutic strategy. Well known glycolytic enzymes such as glyceraldehyde-3-phosphate dehydrogenase may play roles in other cellular processes such as apoptosis.\nConcepts: glands seminal (Prostate and seminal vesicle)\tperiodic partitioning (Organism Function)\tFracture of Skull Related to Birth (Fracture Related to Birth)\tGlycolysis Pathway (Carbohydrate Metabolism Pathway)\tC-SSRS Baseline/Screening Version - Number of Aborted Suicide Attempts (Intellectual Product)", + "output": "Glycolysis Pathway (Carbohydrate Metabolism Pathway)" + }, + { + "input": "Definition: something described as a device designed to signal the presence of a specific condition.\nConcepts: Level of evidence (research clinical testing)\tDetector (Medical Device)\tHigh Sensitivity Troponin T (Assay)\tBMP receptor binding (Molecular Function)\tSerum Bactericidal Antibody Assays (Laboratory Procedure)", + "output": "Detector (Medical Device)" + }, + { + "input": "Definition: Organic Chemical described as new Zealand spider.\nConcepts: N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide (Antihormone)\tViscus (Body Part, Organ, or Organ Component)\tregistrationRequiredIndicator (Qualitative Concept)\tLatrodectus kalipo / New Zealand spider (Organic Chemical)\tLOINC Root (Information Resources)", + "output": "Latrodectus kalipo / New Zealand spider (Organic Chemical)" + }, + { + "input": "Definition: something described as therapeutic inter-phalangeal (IP) orthoses designed for external modification of the structural and/or functional characteristics of the fingers by providing a controlled flexion of the proximal IP joint and simultaneous extension of the distal IP joint during therapeutic treatment. Known as neck-swan splints, these orthoses typically consist of a padded angled splint extending along the finger. The splint includes several straps encircling the finger. Neck-swan splints are used for therapy after surgical correction of neck-swan deformities of the fingers.\nConcepts: Trichopodaceae Hutch., 1934 (Magnoliopsida)\tHigh-Risk, Non-Muscle Invasive Bladder Urothelial Carcinoma (Urinary system finding)\tBroholmer (Non-Sporting Breed)\tFACT-COG Version 3 Questionnaire Question (Intellectual Product)\tOrthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Therapeutic, Swan-Neck Splint (Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Therapeutic)", + "output": "Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Therapeutic, Swan-Neck Splint (Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Therapeutic)" + }, + { + "input": "Definition: Qualitative Concept described as a descriptive characterization of the size of the left cardiac ventricle.\nConcepts: cellular response to heparin (Cell Function)\tLeft Ventricle Size, Qualitative (Qualitative Concept)\tBrittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome (Genetic defect of hair shaft)\tArmadillo Repeat Gene Deleted In Velocardiofacial Syndrome wt Allele (Gene or Genome)\tNot above waist (Clinical or Research Assessment Answer)", + "output": "Left Ventricle Size, Qualitative (Qualitative Concept)" + }, + { + "input": "Definition: regulation of protein-containing complex assembly described as any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion.\nConcepts: gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate (aerobic gallate catabolic process)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Light Chain, Kappa (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Light Chain)\tregulation of synaptic vesicle priming (Cell Function)\thydroxysuccinic acid secretion (malate transport)\tStage III Hepatocellular Cancer (Stage III Liver Cancer)", + "output": "regulation of synaptic vesicle priming (Cell Function)" + }, + { + "input": "Definition: Epileptic drop attack described as a focal seizure characterized at onset by sudden loss or diminution of muscle tone without apparent preceding myoclonic or tonic activity, typically lasting more than 500 ms but less than 2 seconds. It may involve the head, trunk, jaw or limb musculature.\nConcepts: Partial hypotonic seizure (Epilepsy, Partial, Motor)\tKDR wt Allele (Gene or Genome)\tHADS01-Something Awful About to Happen (Intellectual Product)\tsteroid 22-alpha hydroxylase activity (steroid hydroxylase activity)\tmetronidazole hydrochloride (metronidazole)", + "output": "Partial hypotonic seizure (Epilepsy, Partial, Motor)" + }, + { + "input": "Definition: Gene or Genome described as human NOTCH1 wild-type allele is located in the vicinity of 9q34.3 and is approximately 51 kb in length. This allele, which encodes neurogenic locus notch homolog protein 1 protein, plays a role in developmental processes by controlling cell fate decisions.\nConcepts: regulation of membrane repolarization during ventricular cardiac muscle cell action potential (regulation of ventricular cardiac muscle cell action potential)\tNotch Homolog 1, Translocation-Associated (Drosophila) Gene (NOTCH1 gene)\tByssochlamys (Ascomycota)\tRicin A Chain (Ricin)\tAbility to kneel in bath (Ability to perform bathing activity)", + "output": "Notch Homolog 1, Translocation-Associated (Drosophila) Gene (NOTCH1 gene)" + }, + { + "input": "Definition: something described as the process of directing proteins towards a membrane, usually using signals contained within the protein.\nConcepts: recombinant hsp110-gp100 chaperone complex vaccine (Pharmacologic Substance)\tmitochondrial (Membranous cytoplasmic organelle)\tCyclooxygenase Interaction (Enzyme Interaction)\tproxy-reported outcome (Finding)\tprotein targeting to membrane (establishment of protein localization to membrane)", + "output": "protein targeting to membrane (establishment of protein localization to membrane)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Sudden violent death (for example, homicide, suicide): Not sure.\nConcepts: Short proximal phalanx of the 4th finger (Short proximal phalanx of finger)\tdiaphragmatic injury (muscle injury)\tSYSTEM,BLOOD COLLECTION,VACUUM-ASSISTED,AUTOMATED (Medical Device)\tLEC01-Sudden Violent Death: Not Sure (LEC-5 Standard Version Questionnaire Question)\tvasopressin secretion (Cell Function)", + "output": "LEC01-Sudden Violent Death: Not Sure (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: something described as production of genetic alterations by any technique, including chemicals, radiation, recombination, or other molecular biology methods.\nConcepts: Molecular Biology, Mutagenesis (Molecular Analysis)\tHypoplastic areola (Breast)\tITGA6B (Gene or Genome)\tCapsule, hard (Biomedical or Dental Material)\tRecurrent Invasive Ductal Breast Carcinoma (Invasive Ductal Breast Carcinoma)", + "output": "Molecular Biology, Mutagenesis (Molecular Analysis)" + }, + { + "input": "Definition: O-glycan processing described as the stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc.\nConcepts: Raspberry mark of skin (Skin Diseases, Vascular)\tGenome, NOS (GENES: GENERAL TERMS)\tHecks Disease (Disease or Syndrome)\tcyanidin 3-O-glucoside 5-O-glucosyltransferase (acyl-glucose dependent) activity (hexosyltransferase activity)\tO-glycan processing, core 8 (Molecular Function)", + "output": "O-glycan processing, core 8 (Molecular Function)" + }, + { + "input": "Definition: P [Preparations] described as a drug used to treat depression and anxiety disorders. It is a type of selective serotonin reuptake inhibitor (SSRI).\nConcepts: CRSR01-Date of Onset (CRS-R Clinical Classification Question)\tPARoxetine hydrochloride (antidepressants paroxetine)\tPACE Protein (Proprotein Convertases)\thuman papillomavirus vaccine, L1 type 16, 18 (Human Papilloma Virus Vaccine)\tCostal (Rib Cage)", + "output": "PARoxetine hydrochloride (antidepressants paroxetine)" + }, + { + "input": "Definition: Laryngeal Diseases described as stricture or narrowing of the larynx that may be associated with symptoms of respiratory difficulty depending on the degree of laryngeal narrowing.\nConcepts: Sodium, Azathioprine (Carcinogens)\tSmoker's boils (Bacterial pyoderma)\tbiogenic polyamines (acetylcholine)\tlaryngeal stenosis (Congenital abnormality of respiratory system)\tDeoxyribose (Deoxy Sugars)", + "output": "laryngeal stenosis (Congenital abnormality of respiratory system)" + }, + { + "input": "Definition: something described as the nucleus of the microsporocyte. The microsporocyte is a diploid cell in which meiosis will occur, resulting in four microspores. A microspore is a spore that, in vascular plants, gives rise to a male gametophyte.\nConcepts: bile acid catabolism (bile acid metabolism)\tmethylarsonite methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)\tpollen mother cell nucleus (Cell Component)\tINSERT, PUMP, BLOOD (Medical Device)\tKluyvera ascorbata Farmer et al. 1981 (Bacterium)", + "output": "pollen mother cell nucleus (Cell Component)" + }, + { + "input": "Definition: Manufactured Object described as an amplifier that doubles the voltage or frequency of an input signal.\nConcepts: Suppmt Mon Actv (Document type)\t(+)-secoisolariciresinol anabolism ((+)-secoisolariciresinol metabolic process)\tDoubler Device (Manufactured Object)\toral AZA (Pharmacologic Substance)\tExocrine Pancreatic Cancer pNX TNM Finding v8 (Finding)", + "output": "Doubler Device (Manufactured Object)" + }, + { + "input": "Definition: something described as a coded value specifying the kind of epoch.\nConcepts: Date of Approval (Date in time)\tEpoch Type Code (Intellectual Product)\tDisorder of female genital system (Female Genital Diseases)\tAbbesses (Professional or Occupational Group)\t6: 34312628-34321986 (Spatial Concept)", + "output": "Epoch Type Code (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as group of enzymes that catalyze the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.\nConcepts: SAFE (Standard)\tI have pain in my fingertips (Intellectual Product)\tCD40 receptor binding (Molecular Function)\tfemale germ-line stem cell population maintenance (Organism Function)\tKinase, Serine (Amino Acid, Peptide, or Protein)", + "output": "Kinase, Serine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Energy Output Problem described as problem associated with the energy output from the device being inconsistent over time.\nConcepts: Intermittent Energy Output (Finding)\tATP-Dependent DNA Helicase Q4 (Enzyme)\tmitochondrial promoter sequence-specific DNA binding (transcription regulatory region sequence-specific DNA binding)\tresponse to oomycetes associated molecule (Organism Function)\tCarmustine/Doxorubicin/Prednisone/Vindesine (Therapeutic or Preventive Procedure)", + "output": "Intermittent Energy Output (Finding)" + }, + { + "input": "Definition: Research Techniques described as techniques based on the principles of physical and chemical science, for the study of biological problems.\nConcepts: TGG codon-amino acid adaptor activity (triplet codon-amino acid adaptor activity)\tZNc3 (Antineoplastic Enzyme Inhibitor)\tFentanyl Citrate Buccal Tablet (Clinical Drug)\tMalignant fibrous mesothelioma (Diffuse malignant mesothelioma)\tPhysical Chemical Technique (Research Activity)", + "output": "Physical Chemical Technique (Research Activity)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a subjective score of 2 on a motivation scale that ranges from 1: Not at all motivated to 7: Extremely motivated.\nConcepts: Desmoplastic Infantile Ganglioglioma (Ganglioglioma)\tMagnetic Resonance Unsafe (Functional Concept)\tBatrachochytrium (Rhizophydiales incertae sedis)\thomoserine metabolism (serine family amino acid metabolic process)\tMotivation Score 2 (Intellectual Product)", + "output": "Motivation Score 2 (Intellectual Product)" + }, + { + "input": "Definition: something described as an inhibitor of the 19S proteasome-specific deubiquitylating enzymes (DUBs) USP14 and UCHL5, with apoptosis-inducing and antineoplastic activities. Upon administration, VLX1570 specifically binds to both USP14 and UCHL5, thereby blocking their deubiquitylating activity. This blocks the ubiquitin proteasome degradation pathway, prevents the degradation of defective proteins, and leads to an accumulation of poly-ubiquitylated proteins. This induces the unfolded protein response (UPR) and results in both the induction of tumor cell apoptosis and the inhibition of tumor cell growth. USP14 and UCHL5, overexpressed in various tumor cell types, play a key role in the correct folding and deubiquitination of proteins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121215\" active clinical trials using this agent.\nConcepts: USP14/UCHL5 inhibitor VLX1570 (Proteasome inhibitor)\tMurinae (Mammal)\tgeranylgeranyltransferase I inhibitor (Enzyme Inhibitor Drugs)\tAbnormality of vision (Finding)\tpurine deoxyribonucleotide metabolism (2'-deoxyribonucleotide metabolic process)", + "output": "USP14/UCHL5 inhibitor VLX1570 (Proteasome inhibitor)" + }, + { + "input": "Definition: Immunologic Factor described as cardiotrophin-like cytokine factor 1 (225 aa, ~25 kDa) is encoded by the human CLCF1 gene. This protein is involved in cytokine signaling.\nConcepts: downregulation of myoblast differentiation (Cell Function)\tPopulation-Level Process (Biological Processes)\tHAMD2-Obsessional/Compulsive Symptoms (HAMD 21 Questionnaire Question)\tB-Cell Stimulating Factor-3 (Immunologic Factor)\tSunflower Seed Oil (S [Preparations])", + "output": "B-Cell Stimulating Factor-3 (Immunologic Factor)" + }, + { + "input": "Definition: something described as the value in which the outcome of the pharmacokinetic parameter was originally reported.\nConcepts: hesitancy of micturition (Functional abnormality of the bladder)\tPancreatic Infection (Pancreatic Diseases)\tPODCI Adolescent Parent-Reported Version - Open a Jar Been Opened Before (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tPPORRES (Quantitative Concept)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ANG (Medical Device)", + "output": "PPORRES (Quantitative Concept)" + }, + { + "input": "Definition: Physiologic Function described as gluconeogenesis Inhibition involves interference with, or restraint of, the biosynthesis of glucose from 3-carbon non-carbohydrate precursors, including amino acids.\nConcepts: cell division inhibitor AK-01 (Pharmacologic Substance)\tBCG65-E7 (Cancer Vaccines)\tinhibition of gluconeogenesis (Physiologic Function)\tClinical Governance (Health Care Activity)\tHave Abdominal Cramps or Discomfort Due to Diarrhea (Clinical or Research Assessment Question)", + "output": "inhibition of gluconeogenesis (Physiologic Function)" + }, + { + "input": "Definition: Gene or Genome described as human PAX1 wild-type allele is located in the vicinity of 20p11.2 and is approximately 10 kb in length. This allele, which encodes paired box protein Pax-1, plays a role in transcriptional regulation.\nConcepts: CSGRAN (Laboratory Procedure)\tMOUTHWASH (Cosmetics)\tResource Provider (Professional Organization or Group)\tPaired Domain Gene HuP48 (PAX1 gene)\tDiphosphoglyceric Acids (glyceric acid)", + "output": "Paired Domain Gene HuP48 (PAX1 gene)" + }, + { + "input": "Definition: MULTISYSTEM DISORDER described as a chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension.\nConcepts: SSc, Diffuse Sclerosis (Autoimmune connective tissue disorder)\tCommunication skills training (Therapeutic or Preventive Procedure)\tnegative regulation of ascospore formation (Cell Function)\t9-Eicosenoic Acid (Organic Chemical)\tToc complex (Cell Component)", + "output": "SSc, Diffuse Sclerosis (Autoimmune connective tissue disorder)" + }, + { + "input": "Definition: Qualitative Concept described as the chemical and physical integrity of a pharmaceutical product.\nConcepts: Breast Fibroepithelial Neoplasm (Neoplasms, Fibroepithelial)\tSpecialization (Student Characteristics & Academic Environment)\tdrug stability (Technology, Pharmaceutical)\twritten language (Intellectual Product)\t1-543 ESOPHAGUS: EXCISIONS (Oesophageal therapeutic procedures)", + "output": "drug stability (Technology, Pharmaceutical)" + }, + { + "input": "Definition: Common atrioventricular canal described as an ostium primum atrial septal defect is located in the most anterior and inferior aspect of the atrial septum. The ostium primum refers to an anterior and inferior opening (ostium) within the septum primum, which divides the rudimentary atrium during fetal development. The ostium primum is normally sealed by fusion of the superior and inferior endocardial cushions around 5 weeks' gestation. Ostium primum defects result from a failure of the fusion of the embryologic endocardial cushion and septum primum.\nConcepts: Abnormal albumin levels in cerebrospinal fluid (Finding)\tAtrioventricular septal defect, partial (Congenital abnormality of cardiac ventricle)\tDoes not prepare meal (Clinical or Research Assessment Question)\tAttention - Letters (Research or Clinical Assessment Tool)\tMonitors, Electrical Safety, Line Isolation (Medical Device)", + "output": "Atrioventricular septal defect, partial (Congenital abnormality of cardiac ventricle)" + }, + { + "input": "Definition: Benign Cutaneous Fibroblastic Neoplasm described as a benign neoplasm characterized by the presence of spindle-shaped fibroblasts surrounding the hair follicle.\nConcepts: Trichoblastic Fibroma (Neoplastic Process)\tCertified Pediatric Oncology Nurse (Biomedical Occupation or Discipline)\tStandard weaning infant formula (Standard infant formula)\tGrade 5 Neonatal Hypotension (Neonatal Hypotension, Adverse Event)\tup regulation of epidermis development (Organ or Tissue Function)", + "output": "Trichoblastic Fibroma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a person's ability to walk in corridor on unit.\nConcepts: Recurrent Chromophobe Renal Cell Carcinoma (Chromophobe Renal Cell Carcinoma)\tbis(5'-nucleosyl)-tetraphosphatase activity (Molecular Function)\tStudy Subj Med Img Unsp (Research Activity)\tTesticular Cancer Serum Markers Test Result S3 (Testicular Cancer Serum Markers Test Result)\tAbility to walk in corridor (Finding)", + "output": "Ability to walk in corridor (Finding)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines.\nConcepts: 4-Beta-Hydroxycholesterol (Cholesterol measurement test)\tLow Or Decreased Apgar Score (Apgar Score)\tregulation of chemokine biosynthetic process (regulation of chemokine production)\tRitonavir (Organic Chemical)\tChondroitin Sulfate Proteoglycan 7 (Amino Acid, Peptide, or Protein)", + "output": "regulation of chemokine biosynthetic process (regulation of chemokine production)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Microbiology, Bacteria, Susceptibility, Automated Test described as microbiology reagents used in automated analyzers to assess the susceptibility of bacteria to antibacterial agents (e.g., antibiotics) by differentiating between the categories of susceptible, moderately susceptible, or resistant (called break-point tests).\nConcepts: Q16H (Schedule Frequency)\tcambodia (Asia, Southeastern)\tCTX (Pharmacologic Substance)\tPharmacotherapy Regimens (Terminology Subset)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Susceptibility, Automated Test, Break-Point (IVD Test Reagent/Kits, Microbiology, Bacteria, Susceptibility, Automated Test)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Susceptibility, Automated Test, Break-Point (IVD Test Reagent/Kits, Microbiology, Bacteria, Susceptibility, Automated Test)" + }, + { + "input": "Definition: something described as brief Pain Inventory - Check Yes or No if the adjective applies to your pain: aching.\nConcepts: Simmiparib (Pharmacologic Substance)\tevidence base medicine (Clinical Medicine)\tNM 005228.3:c.2302 2303ins9 (Cell or Molecular Dysfunction)\tL Type Calcium Channel (Calcium Channel)\tBPI - Aching (BPI Questionnaire Question)", + "output": "BPI - Aching (BPI Questionnaire Question)" + }, + { + "input": "Definition: Temporal Concept described as the date (and time) when the study subject is removed from the study. EXAMPLE(S): The subject is not being followed and will not be retreated. OTHER NAME(S): NOTE(S): Derived from PerformedStudySubjectMilestone.dateRange WHERE PerformedActivity > DefinedActivity.nameCode = \"remove subject from study\".\nConcepts: PerformedStudySubjectMilestone.offStudyDate (Off Study Date)\tsensory organ development (Organ or Tissue Function)\tstoneworts (Plant)\tYlang-Ylangs (Annonaceae)\tApplication Program Interface (Intellectual Product)", + "output": "PerformedStudySubjectMilestone.offStudyDate (Off Study Date)" + }, + { + "input": "Definition: Intellectual Product described as screener and Opioid Assessment for Patients with Pain - Revised - How often do you feel bored?\nConcepts: Premature Deaths (Mortality Vital Statistics)\tUPD2303B (Intellectual Product)\tHypothyroid Goiter (Goiter)\tWaardenburg syndrome type I (Disease or Syndrome)\tSOAPR1-How Often Feel Bored (SOAPP-R Questionnaire Question)", + "output": "SOAPR1-How Often Feel Bored (SOAPP-R Questionnaire Question)" + }, + { + "input": "Definition: regulation of cellular response to stress described as any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a cellular response to amino acid starvation.\nConcepts: Polyps (Proliferation)\tIVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Nephrogenic Diabetes Insipidus, Del/Dup (IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Nephrogenic Diabetes Insipidus)\tEC 1.1.99.1 (Oxidoreductase)\tregulation of eIF2 alpha phosphorylation by amino acid starvation (regulation of cellular response to stress)\tMPAI132B (Intellectual Product)", + "output": "regulation of eIF2 alpha phosphorylation by amino acid starvation (regulation of cellular response to stress)" + }, + { + "input": "Definition: something described as a special class of inhalations consisting of a drug or combination of drugs, that by virtue of their high vapor pressure, can be carried by an air current into the nasal passage where they exert their effect; the container from which the inhalant generally is administered is known as an inhaler.\nConcepts: inhalant (GasSolidSpray)\taluminum anal.ea.tst (Trace element measurement)\tRadial hypoplasia, triphalangeal thumbs, hypospadias, and maxillary diastema (Hypospadias)\tADP-D-ribose binding (heterocyclic compound binding)\tEpithelium of choroid plexus of fourth ventricle (Tissue)", + "output": "inhalant (GasSolidSpray)" + }, + { + "input": "Definition: Maternal Great Grandparent described as the grandfather on one's mother's side.\nConcepts: negative regulation of antibody-dependent cell death (Cell Function)\tAxis of the Centriole (Cardinal cell part)\tMaternal great grandfather (Family Group)\tCD40L (Protein or Enzyme Type Measurement)\tCD27 receptor binding (Molecular Function)", + "output": "Maternal great grandfather (Family Group)" + }, + { + "input": "Definition: N-terminal protein amino acid modification described as the carboxylation of the N-terminal amino acid of proteins.\nConcepts: Supraglottic Cancer pT0 TNM Finding v7 (Finding)\tCapecitabine RDT (pyrimidine analog)\tN-terminal protein amino acid carboxylation (Molecular Function)\tPIO (Health Care Related Organization)\t/mL (Unit of Number Concentration)", + "output": "N-terminal protein amino acid carboxylation (Molecular Function)" + }, + { + "input": "Definition: Organism Function described as functions of the range and ease of movement of the pelvis.\nConcepts: Cervical Low Grade Neuroendocrine Tumor, Grade 1 (Neoplastic Process)\tAbility to sit in bath (Finding)\tAEENTPT (Temporal Concept)\tMobility of pelvis (Mobility of bone functions)\tbenchmark (Quantitative Concept)", + "output": "Mobility of pelvis (Mobility of bone functions)" + }, + { + "input": "Definition: Enzyme described as protein-glutamine gamma-glutamyltransferase Z (710 aa, ~80 kDa) is encoded by the human TGM7 gene. This protein is involved in protein cross-linking and conjugation of polyamines to proteins.\nConcepts: EMO111A (ERT Functional Test Question)\tTransglutaminase Z (Acyltransferase)\tfeelings of hopelessness (Level of suffering)\tParty Role (Conceptual Entity)\tVINDOLINE (Pharmacologic Substance)", + "output": "Transglutaminase Z (Acyltransferase)" + }, + { + "input": "Definition: Bacterium described as a genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in SOIL and WATER. Its organisms are also found in raw meats, MILK and other FOOD, hospital environments, and human clinical specimens. Some species are pathogenic in humans.\nConcepts: GovernmentFunding (Governmental or Regulatory Activity)\torganomercurial transmembrane transporter activity (Molecular Function)\tAmisometradine (TYPES AND MISCELLANEOUS DIURETICS)\tFLAVOBACT (BACTERIA AND RICKETTSIAE)\tFAC03607 (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)", + "output": "FLAVOBACT (BACTERIA AND RICKETTSIAE)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of doxorubicin and melphalan that may be used in the treatment of breast cancer.\nConcepts: beta-1,6 glucan catabolic process (beta-glucan catabolic process)\tVSSEQ (Sequence Number)\tCervical agenesis (Congenital Abnormality)\tOccupancies, Bed (Patient Acceptance of Health Care)\tDoxorubicin/Melphalan Regimen (Regimen Used to Treat Breast Carcinoma)", + "output": "Doxorubicin/Melphalan Regimen (Regimen Used to Treat Breast Carcinoma)" + }, + { + "input": "Definition: Electrocardiogram Test described as an electrocardiographic assessment of the typical and atypical cardiac rhythms originating from the sinoatrial node.\nConcepts: Sacral spinal cord structure (Lumbosacral spinal cord)\tFibroameloblastic odontoma (Odontogenic Tumors)\tUltra-low vision (Reduced visual acuity)\tSNRARRY (Intellectual Product)\tSpindle Cell Oncocytoma (Oxyphilic Adenoma)", + "output": "SNRARRY (Intellectual Product)" + }, + { + "input": "Definition: something described as problem associated with the linking of the device having a sufficient open space to prevent gas, liquid or electrical current flow between connectors.\nConcepts: BACS1-Symbol Coding Raw Score (BACS Functional Test Question)\trho Associated Coiled Coil Kinase (Amino Acid, Peptide, or Protein)\tScutellariae / ban zhi lian / huang qin (Oriental herbs and natural substances letter S)\tTimes, Blood Circulation (Diagnostic Procedure)\tDisconnection (Connection Problem)", + "output": "Disconnection (Connection Problem)" + }, + { + "input": "Definition: Choroidal and Ciliary Body Melanoma pT2 TNM Finding v8 described as choroidal and ciliary body melanoma, tumor size category 2 without ciliary body involvement but with extraocular extension 5 mm or less in largest diameter.\nConcepts: RelA-associated inhibitor protein, human (Apoptosis Regulatory Proteins)\tQS-FAQ-NACC Version TEST (CDISC Questionnaire Terminology)\tCOUNTER, CELL, AUTOMATED (Medical Device)\tChoroidal and Ciliary Body Melanoma pT2c TNM Finding v8 (Choroidal and Ciliary Body Melanoma pT2 TNM Finding v8)\tSTENOSIS PYLORIC HYPERTROPHIC CONGENITAL (Congenital megalogastria)", + "output": "Choroidal and Ciliary Body Melanoma pT2c TNM Finding v8 (Choroidal and Ciliary Body Melanoma pT2 TNM Finding v8)" + }, + { + "input": "Definition: Somatoform Disorder described as preoccupations with appearance or self-image causing significant distress or impairment in important areas of functioning.\nConcepts: FAC071-Frustrated by Being Too Tired (FACIT-F Version 4 Questionnaire Question)\tVISION DOUBLE (Visual disturbance)\t10p15.1 (Chromosome band)\t1-deoxy-D-xylulose 5-phosphate reductoisomerase complex (protein-containing complex)\tBody Image Disfunctions (Fear symptoms and phobic disorders)", + "output": "Body Image Disfunctions (Fear symptoms and phobic disorders)" + }, + { + "input": "Definition: Temporal Concept described as every seven days.\nConcepts: KIT, CULTURE, CHROMOSOME (Medical Device)\tEvery 7 Days (Temporal Concept)\tTEA Domain Transcription Factor 4 (Amino Acid, Peptide, or Protein)\tBufo laevis (Amphibian)\tUterine Corpus Adenosarcoma FIGO Stage IIIA (Uterine Corpus Adenosarcoma pT3 TNM Finding v8)", + "output": "Every 7 Days (Temporal Concept)" + }, + { + "input": "Definition: something described as human UBC wild-type allele is located in the vicinity of 12q24.3 and is approximately 3 kb in length. This allele, which encodes ubiquitin protein, is involved in the modulation of protein half-life. The allele is essential for the mediation of nonlysosomal protein processing.\nConcepts: Ubiquitin C wt Allele (Gene or Genome)\tDNA polymerase III, proofreading complex location (Cell Component)\tCysteine proteinase -RETIRED- (Enzymes)\tIL-5 (Interleukin Gene)\tDelusional disorder, somatic type (Delusional disorder)", + "output": "Ubiquitin C wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Diagnosis described as a passage or transfer, as of a disease from one individual to another.\nConcepts: positive regulation of oomycete sporangium development (regulation of oomycete sporangium development)\tactivation of constitutive secretory pathway (Cell Function)\tdiseases of transmission (Disorder Characteristics)\tInterferon alfa 2a (Immunologic Factors)\tCDISC ADAS-Cog - Word Recall: Word 7 (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "diseases of transmission (Disorder Characteristics)" + }, + { + "input": "Definition: transferase complex described as cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A.\nConcepts: isovaleryl-CoA(4-) formation (fatty-acyl-CoA biosynthetic process)\tcysteine synthase complex (Cell Component)\ttotal fissure (Body Space or Junction)\t1E4 YERSINIA (Enterobacteriaceae)\tCarpal Joints (Body Space or Junction)", + "output": "cysteine synthase complex (Cell Component)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ATP + H2O = ADP + phosphate, coupled to the topological linking or unlinking of a cohesin ring complex around homologous chromosomes.\nConcepts: Neurofollicular Hamartoma (Benign Pilar-Associated Mesenchyme Neoplasm)\t2-cyano-1-methyl-3-(2-(((5-methylimidazol-4-yl)methyl)thio)ethyl)guanidine (Guanidines)\tSurvey Administration (Informational Intervention)\tRacemethionine-containing product (Amino Acids)\tcohesin ATPase activity (DNA dependent adenosinetriphosphatase activity)", + "output": "cohesin ATPase activity (DNA dependent adenosinetriphosphatase activity)" + }, + { + "input": "Definition: Translation Process Gene described as this gene plays a role in the initiation of translation.\nConcepts: I-124 Iododeoxyuridine (Nucleic Acid, Nucleoside, or Nucleotide)\tphocomelia of lower limb (Lower Extremity Deformities, Congenital)\tBio engineerings (Biotechnology)\tneuron long process generation (neuron projection morphogenesis)\tEIF3B gene (Translation Process Gene)", + "output": "EIF3B gene (Translation Process Gene)" + }, + { + "input": "Definition: Non-photochromogenic mycobacteria described as a species of aerobic, Gram positive, rod shaped bacterium assigned to the phylum Actinobacteria. This species is acid fast, grows rapidly on egg medium, is urease, arylsulfatase and nitrate reductase positive, benzamidase and isonicotinamidase negative, and has a relatively low tolerance to cefmetazole and cefoxitin. M. peregrinum is found in soil and water-related sources and is related to surgical site and catheter related infections.\nConcepts: Organ, Enamel (Embryonic Structures)\tExtensor Digitorum Communis (Muscle)\tMycobacterium peregrinum (ex Bojalil et al. 1962) Kusunoki and Ezaki 1992 (Rapid growing mycobacteria)\tMUB1-RAD6-UBR2 ubiquitin ligase complex location (Cell Component)\tneurokinin B (Amino Acid, Peptide, or Protein)", + "output": "Mycobacterium peregrinum (ex Bojalil et al. 1962) Kusunoki and Ezaki 1992 (Rapid growing mycobacteria)" + }, + { + "input": "Definition: Nasal Cavity and Ethmoid Sinus Cancer Clinical Distant Metastasis TNM Finding v7 described as nasal cavity and ethmoid sinus cancer without evidence of distant metastasis.\nConcepts: negative regulation of branch elongation involved in ureteric bud branching (negative regulation of branching involved in ureteric bud morphogenesis)\tCalcitriol (Laboratory Procedure)\tShaft of bone (Bone Tissue)\twater flow (fluid flow)\tNasal Cavity and Ethmoid Sinus Cancer cM0 TNM Finding v7 (Nasal Cavity and Ethmoid Sinus Cancer Clinical Distant Metastasis TNM Finding v7)", + "output": "Nasal Cavity and Ethmoid Sinus Cancer cM0 TNM Finding v7 (Nasal Cavity and Ethmoid Sinus Cancer Clinical Distant Metastasis TNM Finding v7)" + }, + { + "input": "Definition: AIDS related complication described as retinopathy resulting from AIDS.\nConcepts: AIDS-Related Retinopathy (AIDS related complication)\tPolytetrafluoroethylene suture (Cardiovascular surgical device)\tFeeling Intensity Score 8 (Clinical or Research Assessment Answer)\tBabesia divergens M'Fadyean & Stockman, 1911 (Babesia)\tStage I Differentiated Thyroid Gland Carcinoma Under 55 Years AJCC v8 (Stage I Differentiated Thyroid Gland Carcinoma AJCC v8)", + "output": "AIDS-Related Retinopathy (AIDS related complication)" + }, + { + "input": "Definition: Finding described as an observation of an individual's larygeal elevation during swallowing.\nConcepts: Impairment of Laryngeal Elevation (Finding)\tanterograde dendritic transport (dendritic transport)\tREDTC (Collection Date Time)\tLimited area (Spatial pattern)\tIncontinence Pants, Liner Retention (Incontinence Pants)", + "output": "Impairment of Laryngeal Elevation (Finding)" + }, + { + "input": "Definition: something described as BRCA1 and BRCA2 were identified genetically as breast cancer susceptibility genes when a single copy of the gene is mutated and are involved in the cellular response to DNA damage, including blocking cell cycle progression and inducing DNA repair to preserve the integrity of the genome during cell division. BRCA1 and BRCA2 induce double-stranded repair of breaks using homologous recombination, in part through activation of RAD51. BRCA1 acts as a ubiquitin ligase targeting the protein FancD2 that activates checkpoint control, integrating the ATM response to ionizing radiation and the FA response to cross-linking agents like mitomycin C. Mutation of one of the several components of the FA complex involved in maintaining integrity of the genome leads to the condition Fanconi anemia. One member of the FA complex was recently identified as BRCA2, which leads to Fanconi anemia when both copies of the gene are mutated. Another related factor involved in the response of cells to DNA damage is the kinase ATM. ATM is mutated in patients with AT, a condition with many similar traits to Fanconi anemia. Like ATM, ATR serves as a checkpoint kinase that halts cell cycle progression and induces DNA repair when DNA is damaged. Loss of ATR results in a loss of checkpoint control in response to DNA damage, leading to cell death. Deletion of the ATR gene in mice is embryonic lethal. ATRIP is a protein that interacts with ATR and is a substrate for its kinase activity. ATRIP is required for ATR function, and removal of ATRIP also leads to a loss of checkpoint control of the cell cycle. ATR and ATM kinase targets include repair enzymes like Rad51, and the checkpoint kinases Chk1 and Chk2, as well as BRCA1 and BRCA2. The close relationship of the genes involved in breast cancer and Fanconi anemia has helped illuminate this signaling system, and may help lead to improved understanding and treatment of these conditions.\nConcepts: Cancer Susceptibility Pathway (Genetic Function)\t2 Oxoisovalerate Dehydrogenase (Oxidoreductase)\tbrachial nutrient artery (Branch of brachial artery)\tMulti-Axes Gantry Positioning Units (Medical Device)\tBladder Angiosarcoma (Soft Tissue Angiosarcoma)", + "output": "Cancer Susceptibility Pathway (Genetic Function)" + }, + { + "input": "Definition: something described as a collection of the smallest blood vessels of the vascular system, which are involved in the exchange of gases, water, nutrients, and waste products, and which includes blood vessels from the first-order arteriole to the first-order venule.\nConcepts: Microvascular Bed (Blood Vessel)\tFatty layer of superficial fascia (White Adipose Tissue)\tbull's eye body (Secretory Granule)\tneural tube closure (tube closure)\tmesonephric collecting tubule development (mesonephric nephron tubule development)", + "output": "Microvascular Bed (Blood Vessel)" + }, + { + "input": "Definition: Medical Device described as stylets designed for use in the lumen of endotracheal tubes during intubation procedures, especially to facilitate the passage of the tracheal tube though the upper airway and vocal cords. These stylets usually are wires or thin flexible metal rods that are inserted into the tracheal tube prior to intubation. Tracheal tube stylets are designed to be slightly shorter than the tracheal tube to avoid damage to the airways during passage; they are usually withdrawn after intubation has been successfully completed. Some dedicated tracheal stylets are for specific laryngoscopes used in intubation.\nConcepts: Haemophilus haemolyticus, Beta-Lactamase Positive (Bacterium)\tTracheal Tube Stylets (Medical Device)\tliposarcoma of breast (Malignant neoplasm of breast)\tFilipino language (Malayo-Polynesian language)\tMetanephric adenoma (Benign adenomatous neoplasm - category)", + "output": "Tracheal Tube Stylets (Medical Device)" + }, + { + "input": "Definition: something described as a disorder present at birth characterized by an electrocardiographic finding of a tachycardia that originates above the ventricles.\nConcepts: post-anaphase microtubule array (Cell Component)\tLigamentous Articular Strain (Ligament finding)\tSupraventricular Tachycardia (SVT), Congenital (Cardiac disorders congenital NEC)\ttroponin test (Protein measurement)\tDefined Observation (Research Activity)", + "output": "Supraventricular Tachycardia (SVT), Congenital (Cardiac disorders congenital NEC)" + }, + { + "input": "Definition: Pharmacologic Substance described as one of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system. Aldesleukin (interleukin-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Interleukin-2 is a type of cytokine.\nConcepts: Thymocyte Stimulating Factor (Pharmacologic Substance)\tAll Pharmacotherapy Prescriptions (Intellectual Product)\ttype 2 metabotropic glutamate receptor binding (G protein-coupled glutamate receptor binding)\tgroup A colicin transmembrane transporter activity (colicin transmembrane transporter activity)\tneurofilament, heavy polypeptide 200kDa (Intermediate Filament Gene)", + "output": "Thymocyte Stimulating Factor (Pharmacologic Substance)" + }, + { + "input": "Definition: Document type described as a Category name for the eTMF domain used to classify a collection of documents related to central laboratory research and reporting for clinical trials.\nConcepts: Abnormal lingual nerve morphology (Anatomical Abnormality)\tnegative regulation of netrin-activated signaling pathway (regulation of netrin-activated signaling pathway)\tspacer (Medical Devices)\tCentralized Testing Category (Document type)\tGenus Rehmannia (Orobanchaceae incertae sedis)", + "output": "Centralized Testing Category (Document type)" + }, + { + "input": "Definition: something described as an order of fungi in the phylum ASCOMYCOTA that includes many valuable experimental organisms. There are eight families and very few anamorphic forms.\nConcepts: Sordariales (Ascomycota)\tDEAD Box Protein 20 (Enzyme)\tTrachea Cartilage (Body Part, Organ, or Organ Component)\tAd5-CMV-NIS (Antineoplastic Agents)\tSternal Bone Awls (Medical Device)", + "output": "Sordariales (Ascomycota)" + }, + { + "input": "Definition: Aplasia/Hypoplasia of the distal phalanges of the toes described as absence of the distal phalanges of the toes.\nConcepts: Analyzers, Point-of-Care, Whole Blood, Ammonia (Analyzers, Point-of-Care, Whole Blood)\tSelf-blame (Emotional state observations)\tCommon Fimbria (cell projection)\tPlanned Repeat Activity Until Rule (Rule)\tAplasia of the distal phalanges of the toes (Aplasia/Hypoplasia of the distal phalanges of the toes)", + "output": "Aplasia of the distal phalanges of the toes (Aplasia/Hypoplasia of the distal phalanges of the toes)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of a methane from a methylamine.\nConcepts: paraformaldehyde (Pulp and root canal devitalizing agent)\tzymogen binding (enzyme binding)\tmethane biosynthetic process from methylamine (Molecular Function)\tIGF1R Positive (Receptor status)\tAbnormal proportion of naive CD8 T cells (Abnormal proportion of naive T cells)", + "output": "methane biosynthetic process from methylamine (Molecular Function)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid.\nConcepts: Stage III Breast Cancer AJCC v7 (Neoplastic Process)\tAlert System, Medication (Intellectual Product)\tregulation of potassium ion membrane transport (Cell Function)\tlysine degradation (Molecular Function)\tinositol phosphate-mediated signalling (Molecular Function)", + "output": "lysine degradation (Molecular Function)" + }, + { + "input": "Definition: something described as the hydrochloride salt of doxorubicin, an anthracycline antibiotic with antineoplastic activity. Doxorubicin, isolated from the bacterium Streptomyces peucetius var. caesius, is the hydroxylated congener of daunorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids; the formation of oxygen free radicals also contributes to the toxicity of the anthracycline antibiotics, namely the cardiac and cutaneous vascular effects.\nConcepts: Interrogate, Failure To (Finding)\tHydroxydaunomycin hydrochloride (doxorubicin)\tarteriovenous shunt (Arteriovenous disorder)\tSDTM-LBTEST (CDISC SEND Terminology)\tLaryngeal Carcinoma cN1 TNM Finding v8 (Finding)", + "output": "Hydroxydaunomycin hydrochloride (doxorubicin)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed death-1 (PD-1, PCD-1,) with immune checkpoint inhibitory and antineoplastic activities. Upon administration, camrelizumab binds to and blocks the binding of PD-1, expressed on activated T lymphocytes, B cells and natural killer (NK) cells, to its ligands programmed cell death ligand 1 (PD-L1), overexpressed on certain cancer cells, and programmed cell death ligand 2 (PD-L2), which is primarily expressed on antigen presenting cells (APCs). This prevents the activation of PD-1 and its downstream signaling pathways. This restores immune function through the activation of cytotoxic T lymphocytes (CTLs) and cell-mediated immune responses against tumor cells or pathogens. Activated PD-1 negatively regulates T-cell activation and plays a key role in tumor evasion from host immunity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C123816\" active clinical trials using this agent.\nConcepts: Chemo/immuno/hormone Therapy Regimen (Therapeutic or Preventive Procedure)\tbasket cell precursor proliferation (cell proliferation in hindbrain ventricular zone)\tCamrelizumab (Immunologic Factor)\tFungitell Assay (Microbiology procedure)\tGrade 3 Sinusoidal obstruction syndrome (Sinusoidal Obstruction Syndrome, CTCAE)", + "output": "Camrelizumab (Immunologic Factor)" + }, + { + "input": "Definition: Disorder of soft tissue of body cavity described as congenital arteriovenous malformation involving the VEIN OF GALEN, a large deep vein at the base of the brain. The rush of arterial blood directly into the vein of Galen, without passing through the CAPILLARIES, can overwhelm the heart and lead to CONGESTIVE HEART FAILURE.\nConcepts: molecular dynamics (Molecular Function)\tupregulation of pentose catabolism to ethanol (positive regulation of cellular carbohydrate metabolic process)\tcongenital anomaly vein of galen malformation (Congenital anomaly of superior vena cava)\tLAPTM5 protein, human (receptor)\tHave Axillary Fullness or Numbness (Intellectual Product)", + "output": "congenital anomaly vein of galen malformation (Congenital anomaly of superior vena cava)" + }, + { + "input": "Definition: Clinical Attribute described as the second most prevalent Gleason pattern in a prostate biopsy or prostatectomy specimen. The Gleason score is defined by adding the most prevalent (primary) and second most prevalent (secondary) patterns.\nConcepts: FIQR01-Lift/Carry Bag Full of Groceries (FIQR Questionnaire Question)\tGLEASON SECONDARY SCORE (Clinical Attribute)\tEndoscopy of larynx, NOS (Airway procedure)\tFree and Sovereign State of Zacatecas (Geographic Area)\tIntrauterine balloon (Obstetrical/gynecological device)", + "output": "GLEASON SECONDARY SCORE (Clinical Attribute)" + }, + { + "input": "Definition: nucleotide-sugar biosynthetic process described as the chemical reactions and pathways resulting in the formation of UDP-D-apiose, uridinediphosphoapicose, a substance composed of apiose in glycosidic linkage with uridine diphosphate.\nConcepts: Ginger product (Non-Standardized Plant Allergenic Extract)\tUnpaired Data (Data)\tneoplasm/cancer vaccine (Vaccines)\tPsychophysics (Behavioral Sciences)\tUDP-D-apiose formation (UDP-D-apiose metabolic process)", + "output": "UDP-D-apiose formation (UDP-D-apiose metabolic process)" + }, + { + "input": "Definition: Laboratory Procedure described as the anticipated or extrapolated frequency of a single nucleotide polymorphism within a population.\nConcepts: ELN Allele with Mm Haplotype for INT20/INT23 (Gene or Genome)\tceroid (Lipids)\tDiffuse haemorrhage of pulmonary alveolar (Pulmonary hemorrhage)\tPredicted SNP Frequency (Laboratory Procedure)\tChallenge Agent Category (Classification)", + "output": "Predicted SNP Frequency (Laboratory Procedure)" + }, + { + "input": "Definition: Finding described as >5.0-20.0 x ULN if baseline was normal; >5.0-20.0 x baseline if baseline was abnormal\nConcepts: Grade 3 Aspartate aminotransferase increased (Aspartate Aminotransferase Increased, CTCAE)\tStructures, Fetal (Gestational structure)\tAnti-CD52 Monoclonal Antibody (Antibodies, Neoplasm)\tTreatment Efficacy (Effectiveness)\tScreening for cardiac condition (Disease Screening)", + "output": "Grade 3 Aspartate aminotransferase increased (Aspartate Aminotransferase Increased, CTCAE)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the RAD54L gene.\nConcepts: G protein-coupled ADP receptor activity (G protein-coupled purinergic nucleotide receptor activity)\tDiaries (Document type)\tmapmodulin protein, human (Regulatory Protein)\tRAD54-like (S. cerevisiae) Gene Mutation (Gene Mutant)\tStage IVA Hypopharynx Carcinoma (Stage IVA Pharyngeal Carcinoma)", + "output": "RAD54-like (S. cerevisiae) Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: Finding described as a semi-quantitative microscopic finding indicating that at least 20 percent of the nucleated cells in a peripheral leukocyte sample are neoplastic plasma cells.\nConcepts: aspartate-2-keto-4-methylthiobutyrate transaminase activity (Molecular Function)\tarf (kidney functional)\tElevated Lactate Level (LABORATORY ABNORMALITIES)\tDENTURE ADHESIVE, KARAYA AND ETHYLENE-OXIDE HOMOPOLYMER (Medical Device)\tNeoplastic Plasma Cells 20 Percent or More of Peripheral Blood White Cells (Neoplastic Plasma Cells More than 5 Percent of Peripheral Blood White Cells)", + "output": "Neoplastic Plasma Cells 20 Percent or More of Peripheral Blood White Cells (Neoplastic Plasma Cells More than 5 Percent of Peripheral Blood White Cells)" + }, + { + "input": "Definition: Toothache, CTCAE described as severe pain; limiting self care ADL\nConcepts: Indian Frankincense Oil (Organic Chemical)\tPROXIMAL INTERPHALANGEAL JOINT 5 OF THE FOOT (Body Part, Organ, or Organ Component)\tGrade 3 Toothache (Toothache, CTCAE)\tDDB1- and CUL4-Associated Factor 2 (Ubiquitination Regulation Protein)\tserums (Body Substance)", + "output": "Grade 3 Toothache (Toothache, CTCAE)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the Cockayne syndrome 1 (CKN1) gene, located at chromosome 5q12.1, which is involved in transcription-coupled DNA repair. Mutations at this locus have been identified in patients with early onset of classical Cockayne's syndrome symptoms, including retinitis pigmentosa.\nConcepts: CEFEPIME (Third generation cephalosporin)\tup-regulation of receptor-mediated endocytosis involved in cholesterol transport (Cell Function)\ttissue resource/registry (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CKN1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tRNA-Binding Protein EWS/POZ-, AT Hook-, and Zinc Finger-Containing Protein 1 Short Isoform (Amino Acid, Peptide, or Protein)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CKN1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: something described as the directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: skull plate (Non-Active Implantable Devices)\tIPAQ Long Last 7 Days Self-Administered Format Version - Traveling Minutes per Day (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tsialic acid transport (Cell Function)\tBar-Code Sponge Retention Prevention Counters (Medical Device)\tHelicos Sequencing Technology (Molecular Biology Research Technique)", + "output": "sialic acid transport (Cell Function)" + }, + { + "input": "Definition: something described as roland Morris Disability Questionnaire (RDQ) My appetite is not very good because of my back pain.\nConcepts: Androst-1-en-3-one, 17-hydroxy-1-methyl-, (5alpha,17beta)- (Organic Chemical)\tStage 0 Rectal Cancer (Stage 0 Colorectal Cancer AJCC v8)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL6A3 (Medical Device)\tIncreased proportion of marginal zone B cells (Finding)\tRDQ0115 (Intellectual Product)", + "output": "RDQ0115 (Intellectual Product)" + }, + { + "input": "Definition: something described as ma qian zi\nConcepts: positive regulation of primary cell septum biogenesis (regulation of primary cell septum biogenesis)\tQ-LES-Q - Felt Independent (Q-LES-Q Questionnaire Question)\tdysplasia severe (DYSPLASIAS: GENERAL TERMS)\tStrychnotis / ma qian zi (Oriental herbs and natural substances letter S)\ttrans-2-phenylcyclopropylamine (Propylamines)", + "output": "Strychnotis / ma qian zi (Oriental herbs and natural substances letter S)" + }, + { + "input": "Definition: Neoplastic Process described as a non-invasive neoplasm that arises from the ovary and is composed of gastrointestinal-type, mucin-containing epithelial cells. It shows greater cellular proliferation and cytologic atypia as compared to benign ovarian mucinous tumors.\nConcepts: MBT/APMT (Borderline Ovarian Mucinous Tumor)\tTSCYC - Being Afraid to Be Alone (TSCYC Questionnaire Question)\tregulation of actin filament annealing (Cell Function)\tp53MVA vaccine (Vaccinia Vaccine)\tdiplopia (Abnormal vision)", + "output": "MBT/APMT (Borderline Ovarian Mucinous Tumor)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of 3-methylbut-2-enoyl-CoA(4-).\nConcepts: First dorsal vertebra (Thoracic spine structure)\tresin-based composite (composite filling)\t3-methylbut-2-enoyl-CoA(4-) breakdown (fatty-acyl-CoA catabolic process)\tpositive regulation of transposition (Genetic Function)\tFLJ20174 (Gene or Genome)", + "output": "3-methylbut-2-enoyl-CoA(4-) breakdown (fatty-acyl-CoA catabolic process)" + }, + { + "input": "Definition: something described as human TTF1 wild-type allele is located in the vicinity of 9q34.13 and is approximately 31 kb in length. This allele, which encodes transcription termination factor 1 protein, is involved in both transcriptional termination and replication fork arrest.\nConcepts: Premature epimetaphyseal fusion in hand (Premature epiphyseal closure)\tAdenylyl Sulfate (Nucleic Acid, Nucleoside, or Nucleotide)\tOesophageal glands (Epithelium of cervical part of esophagus)\tTTF1 wt Allele (TTF1 gene)\tFOXC1 protein, human (TRANSCRIPTION FACTOR)", + "output": "TTF1 wt Allele (TTF1 gene)" + }, + { + "input": "Definition: Plant described as a plant genus of the family MYRTACEAE. The common name of tea tree more often refers to MELALEUCA or LEPTOSPERMUM.\nConcepts: T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif inhibitor MK-7684 (Immunologic Factor)\tAIMS01-Upper Extremities (Intellectual Product)\tUrine Leakage from Urostomy Bag (Intellectual Product)\tKanukas (Leptospermeae)\tMarijuana Smoke Exposure (exposure to smoke)", + "output": "Kanukas (Leptospermeae)" + }, + { + "input": "Definition: Common nursing interventions described as irrigating a patient's enteral tube.\nConcepts: Enteral Tube Irrigation (Therapeutic or Preventive Procedure)\tInfection by Cnidospora, NOS (Mycoses)\tTranslocase Gene (Enzyme Gene)\tColliculus superior, stratum intermedium (Body Part, Organ, or Organ Component)\tdownregulation of epithelial cell differentiation (regulation of epithelial cell differentiation)", + "output": "Enteral Tube Irrigation (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Neuroimaging Initiative Auditory Verbal Learning Test Version A (ADNI-AVLT Version A) List A, Recall 5, Word 7.\nConcepts: Radiant Warmers, Infant (Medical Device)\tSGRQ0246 (Intellectual Product)\tTibia, NOS (Bone structure of lower leg)\tAVL01-List A Recall 5 Word 7 (Intellectual Product)\tIL-1RA (Drug allergens)", + "output": "AVL01-List A Recall 5 Word 7 (Intellectual Product)" + }, + { + "input": "Definition: Software, Nuclear Medicine Study described as nuclear medicine study software designed to acquire, process, and archive data and images obtained from lung studies. The study is usually performed in two parts: first, a series of images are taken after inhalation of a radioactive gas to show the tissue of the lungs; then, a radioactive substance is injected in the bloodstream and more images are taken to check the blood supply to the lungs. This software usually works with a nuclear medicine and/or gamma camera workstation and may also interact with other devices used in the procedures such as scanning gamma cameras. Lung nuclear medicine study software is intended to work only with one or a few models of nuclear medicine equipment and related devices, usually supplied by the same manufacturer. This also facilitates the processing and/or sending of data to other nuclear medicine workstations and hospital information systems. Lung nuclear medicine studies are used mainly to detect air and/or blood circulation in the lungs, especially to find blood clots in the lungs (i.e., to diagnose pulmonary embolism). The software may or may not be available separate from the nuclear medicine equipment and may be updated and/or upgraded (i.e., through the release of modified versions) during the life of the equipment.\nConcepts: Unknown Mechanism of Action (Functional Concept)\tSoftware, Nuclear Medicine Study, Pulmonary (Software, Nuclear Medicine Study)\tregulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway (Wnt signaling pathway, planar cell polarity pathway)\tChest-Wall Compression Units, Vest (Medical Device)\tLipid-Rich Breast Carcinoma (Lipid-rich carcinoma)", + "output": "Software, Nuclear Medicine Study, Pulmonary (Software, Nuclear Medicine Study)" + }, + { + "input": "Definition: NSAA Clinical Classification Question described as north Star Ambulatory Assessment - Can you hop on your right leg?\nConcepts: Mitochondrial disease (Metabolic Diseases)\tNSAA115 (Intellectual Product)\tresearch ethic (general topics in research)\tTriterpenes (Isoprenoids)\tinduction of synaptic vesicle exocytosis by positive regulation of presynaptic cytosolic calcium ion concentration (positive regulation of synaptic vesicle exocytosis)", + "output": "NSAA115 (Intellectual Product)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate.\nConcepts: Stern's Edema Rating 1 (Stern's Rating Scale for Edema)\tNPI1L06 (NPI Questionnaire Question)\tEnteroviral vesicular stomatitis with exanthem (disorder) [Ambiguous] (Skin Diseases, Infectious)\talkyl caffeate ester biosynthetic process (cinnamic acid ester biosynthetic process)\tClot Disruption, Mechanical (Therapeutic or Preventive Procedure)", + "output": "alkyl caffeate ester biosynthetic process (cinnamic acid ester biosynthetic process)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Streptococcus thermophilus.\nConcepts: regulation of response to cycloalkane (Physiologic Function)\tKDPI01-KDPI Score (KDPI Clinical Classification Question)\tATP-gated ion channel activity (ligand-gated channel activity)\tAchalasia and cardiospasm (Achalasia)\tStreptococcus salivarius subsp thermophilus (Bacterium)", + "output": "Streptococcus salivarius subsp thermophilus (Bacterium)" + }, + { + "input": "Definition: Intellectual Product described as baby Eating Behaviour Questionnaire Concurrent Version (BEBQ Concurrent Version) My baby gets full up easily.\nConcepts: Shock (Classification)\tRio de Janeiro (Geographic Area)\tNeonatal Hearing Loss (Deafness)\tMitoch myop/enceph/lact/strke (Mitochondrial Encephalomyopathies)\tBEBQ0107 (Intellectual Product)", + "output": "BEBQ0107 (Intellectual Product)" + }, + { + "input": "Definition: Protein-tyrosine kinase inhibitor described as a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. Adavosertib selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect.\nConcepts: Testicular hormone (HORMONES, VITAMINS AND RECEPTOR SITES)\tRNA Editings (RNA Processing, Post-Transcriptional)\tAcute lipodermatosclerosis (Vascular degeneration)\t2-allyl-1-(6-(2-hydroxy-2-propanyl)-2-pyridinyl)-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-1,2-dihydro-3H-pyrazolo(3,4-d)pyrimidin-3-one (Organic Chemical)\tInner City (Urban environment)", + "output": "2-allyl-1-(6-(2-hydroxy-2-propanyl)-2-pyridinyl)-6-((4-(4-methyl-1-piperazinyl)phenyl)amino)-1,2-dihydro-3H-pyrazolo(3,4-d)pyrimidin-3-one (Organic Chemical)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger.\nConcepts: Penile erection, NOS (Male sexual finding)\tHuman Cardiac Tissue Non-valved (Tissue)\tpuromycin biosynthetic process (purine ribonucleoside biosynthetic process)\tProtein TFG/ALK Tyrosine Kinase Receptor Fusion Protein (Biologically Active Substance)\tcullin family protein binding (Molecular Function)", + "output": "puromycin biosynthetic process (purine ribonucleoside biosynthetic process)" + }, + { + "input": "Definition: Finding described as soft tissue sarcoma of the abdomen and thoracic visceral organs with distant metastases.\nConcepts: negative regulation of anterior head development (negative regulation of developmental process)\tManipulators, Uterine (Surgical Instruments)\tPosterior vascular renal segment of right kidney (Parenchyma of right kidney)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs cM1 TNM Finding v8 (Finding)\tsensory threshold (Perception)", + "output": "Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs cM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: OAB-q Short Form Questionnaire Question described as the Overactive Bladder Questionnaire Short Form (OAB-q Short Form) Caused you to have problems with your partner or spouse?\nConcepts: COXEN Sensitivity Scale (Research or Clinical Assessment Tool)\tLaparoscopic swab forceps (Medical Device)\tNPS01TN (Intellectual Product)\tYour feeling bloated at its worst (Clinical or Research Assessment Question)\tOAB-q Short Form - Caused Problems with Your Partner or Spouse (Intellectual Product)", + "output": "OAB-q Short Form - Caused Problems with Your Partner or Spouse (Intellectual Product)" + }, + { + "input": "Definition: Malignant neoplasm of liver described as a malignant neoplasm of the liver arising from/comprising cells resembling those of bile ducts.\nConcepts: colles' fracture (Eponymic Fractures and Dislocations)\tanterior superior temporal sulcus (Body Space or Junction)\t25(OH)D Less than 66 ng/mL (Laboratory test finding)\tOvarian Germ Cell Teratoma Stage IV (Stage IV Ovarian Germ Cell Tumor AJCC v6 and v7)\tIntrahepatic Bile Duct Carcinoma (Liver and Intrahepatic Biliary Tract Carcinoma)", + "output": "Intrahepatic Bile Duct Carcinoma (Liver and Intrahepatic Biliary Tract Carcinoma)" + }, + { + "input": "Definition: Excretion Rate described as the excretion rate over the interval from T1 to T2, determined for the specimen type specified in PPSPEC.\nConcepts: Hypoxicators (Medical Device)\tExcretion Rate From T1 to T2 (Quantitative Concept)\tambulatory electrocardiographic monitor (Monitoring, Ambulatory)\tChemical Compresses/Packs, Hot (Medical Device)\tSyndrome, Alagille (Autosomal dominant hereditary disorder)", + "output": "Excretion Rate From T1 to T2 (Quantitative Concept)" + }, + { + "input": "Definition: Resectable Carcinoma described as squamous cell carcinoma of the head and neck which is amendable to surgical removal.\nConcepts: berbamunine anabolism (Molecular Function)\tResectable Head and Neck Squamous Cell Cancer (Resectable Carcinoma)\tVz Obs by F for UB (Observed Volume of Distribution of Absorbed Fraction)\tsyndactyly-cataracts-mental retardation syndrome (Disease or Syndrome)\tmiddle viral transcription (Viral Transcription)", + "output": "Resectable Head and Neck Squamous Cell Cancer (Resectable Carcinoma)" + }, + { + "input": "Definition: UPDRS Questionnaire Question described as unified Parkinson's Disease Rating Scale - Activities of daily living (for both 'on' and 'off'): Dressing.\nConcepts: UPD1-Activities:Dressing (Intellectual Product)\tStartle epilepsy (Disease or Syndrome)\tCan you go shopping for groceries or clothes (Intellectual Product)\tTSCYC1TC (Intellectual Product)\tAnti-PD-1/PD-L1 Bispecific Antibody LY3434172 (Pharmacologic Substance)", + "output": "UPD1-Activities:Dressing (Intellectual Product)" + }, + { + "input": "Definition: Cell Count described as the determination of the ratio of the G6PD-deficient erythrocytes as compared to the total erythrocytes present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Prognostic Stage IIB Breast Carcinoma AJCC v8 (Prognostic Stage II Breast Cancer AJCC v8)\tSamoa Standard Time (Temporal Concept)\tG6PDRBRB (Laboratory Procedure)\tStimulators, Mechanical, Tactile (Stimulators, Mechanical)\tUnknown Transformation (Qualitative Concept)", + "output": "G6PDRBRB (Laboratory Procedure)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about whether an individual feels or felt they have no choice about the amount of money they spend on care.\nConcepts: I feel I have no choice about the amount of money I spend on care (Intellectual Product)\tCerebro-facio-thoracic dysplasia (Mental Retardation)\thepatic phosphorylase deficiency (Disease or Syndrome)\t4-toluenecarboxylate metabolic process (Molecular Function)\tAbnormal cervical spine morphology (Anatomical Abnormality)", + "output": "I feel I have no choice about the amount of money I spend on care (Intellectual Product)" + }, + { + "input": "Definition: Spatial Concept described as physical location of AKAP12_Gene\nConcepts: positive regulation of cytokine secretion (regulation of cytokine secretion)\tCancer/Testis Antigen 45-2 (Tumor-Related Protein)\t2-(Imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid (Metabolic Bone Disease Agents)\t6: 151653623-151770023 (Spatial Concept)\tvacuolar protein processing (Molecular Function)", + "output": "6: 151653623-151770023 (Spatial Concept)" + }, + { + "input": "Definition: Bodywork described as using pressure-point techniques on a client's body part, region or full body to identify and reeducate the proprioceptor nerve ending activity within his or her muscle(s) to regain and/or maintain balance within the body. Any practitioner using this code must document appropriate training and/or certification. Service is billed in 15-minute increments.\nConcepts: Porphobilinogen (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tdeisopropylatrazine monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)\tcytosine catabolism (pyrimidine nucleobase catabolic process)\tOrtho-Bionomy(TM) each 15 minutes (Therapeutic or Preventive Procedure)\tregulation of protein localization to actin cortical patch (regulation of protein localization to cell cortex)", + "output": "Ortho-Bionomy(TM) each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: negative regulation of mitochondrial translation described as any process that stops, prevents, or reduces the frequency, rate or extent of the process preceding formation of the peptide bond between the first two amino acids of a protein in a mitochondrion.\nConcepts: negative regulation of mitochondrial translation initiation (regulation of mitochondrial translational initiation)\tNurse comprehensive new in-office 60 minutes (New client in-office with nursing diagnosis)\tOropharyngeal (p16-Negative) Carcinoma pN3 TNM Finding v8 (Finding)\tCephalometers (Medical Device)\tAVL01033 (ADNI-AVLT Questionnaire Question)", + "output": "negative regulation of mitochondrial translation initiation (regulation of mitochondrial translational initiation)" + }, + { + "input": "Definition: coenzyme A transport described as the process in which coenzyme A is transported across a membrane. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.\nConcepts: Injection, Powder, for Solution (Powder dose form)\tscans vq (Radionuclide Imaging)\tCarbohydrate Sequence (Carbohydrate Sequence)\tcoenzyme A membrane transport (coenzyme A transport)\tWeight Loss Behavior (Finding)", + "output": "coenzyme A membrane transport (coenzyme A transport)" + }, + { + "input": "Definition: Non-Neoplastic Retinal Disorder described as group of inherited abnormalities in the retina; characterized by night blindness, retinal atrophy, weakening of the retinal vessels, pigment clumping, and contraction of the visual field.\nConcepts: degeneration; tapetoretinal (Hereditary retinal dystrophy)\t(1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-Tetraene-1,3,24,25-Tetrol (Organic Chemical)\tCap Binding Protein Complex (Amino Acid, Peptide, or Protein)\tFAC01711 (Intellectual Product)\tHamartoma of the Central Nervous System (Hamartoma)", + "output": "degeneration; tapetoretinal (Hereditary retinal dystrophy)" + }, + { + "input": "Definition: Intellectual Product described as performance of the Upper Limb Module for DMD Version 2.0 (PUL V2.0) (Mayhew A, Mazzone ES, Eagle M, et al. (2013). Development of the Performance of the Upper Limb module for Duchenne muscular dystrophy. Dev Med Child Neurol; 55:1038-45).\nConcepts: PUL V2.0 (Intellectual Product)\tnegative regulation of ribonuclease activity (regulation of ribonuclease activity)\tAbsent thoracic vertebra (Congenital absence of vertebra)\tMyocardial granulomatous infiltrates (Finding)\tTables, Examination/Treatment, Adjustable, Proctologic (Tables, Examination/Treatment, Adjustable)", + "output": "PUL V2.0 (Intellectual Product)" + }, + { + "input": "Definition: Miscellaneous Concentration Unit described as a concentration unit measured as a number of one thousandth of an equivalent weight per millimole of substance.\nConcepts: I have trouble feeling the shape of small objects when they are in my hand (Intellectual Product)\tExtent Have Trouble Talking to Other People (Intellectual Product)\tANTIGEN, BENTONITE FLOCCULATION, TRICHINELLA SPIRALIS (Indicator, Reagent, or Diagnostic Aid)\tmeq/mmol (Miscellaneous Concentration Unit)\tImmune Response Regulation Pathway (Regulatory Pathway)", + "output": "meq/mmol (Miscellaneous Concentration Unit)" + }, + { + "input": "Definition: something described as a trial with the primary objective of showing that the response to the investigational product is superior to a comparative agent (active or placebo control).\nConcepts: Stage IA1 Cervical Carcinoma FIGO 2018 (Neoplastic Process)\tStapedial artery (Branch of stylomastoid artery)\tLocking Electric Receptacles (Medical Device)\tPosterior aortic valve cusp (Aortic valve structure)\tSuperiority Trial (Clinical Trials)", + "output": "Superiority Trial (Clinical Trials)" + }, + { + "input": "Definition: Bcl-2 family protein complex described as a heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.\nConcepts: CBA (Laboratory Procedure)\tBIM-BCL-2 complex (Cell Component)\tSubcellular Fraction (Cellular Structures)\tInvasive Lobular Breast Carcinoma, Solid Variant (Neoplastic Process)\tBacillus cereus var. thuringiensis (Genus Bacillus)", + "output": "BIM-BCL-2 complex (Cell Component)" + }, + { + "input": "Definition: Alkylating Agents described as toxic alkylating agent used in industry; also as antineoplastic and research tool to produce chromosome aberrations and cancers.\nConcepts: Macroscopic Findings Anatomical Region of Specimen (Other Anatomic Concept)\tatrial flutter typical (Atrial Flutter)\tneurotransmitter loading into synaptic vesicle (neurotransmitter transport)\tTEM (Alkylating Agents)\tAraucaria (Araucariaceae)", + "output": "TEM (Alkylating Agents)" + }, + { + "input": "Definition: Molecular Function described as the aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.\nConcepts: IVD Test Reagent/Kits, Clinical Chemistry, Enzyme, 2-Hydroxybutyrate Dehydrogenase (IVD Test Reagent/Kits, Clinical Chemistry, Enzyme)\tStage I Prostate Cancer (Prostate Cancer by AJCC v7 Stage)\t19: 7718406-7710882 (Spatial Concept)\treceptor-receptor interaction (signaling receptor binding)\tRibosome Inactivation (Ribosomal Function Inhibition)", + "output": "receptor-receptor interaction (signaling receptor binding)" + }, + { + "input": "Definition: Neonatal Tachyarrhythmia, Adverse Event described as brief, self-limiting, episodes of asymptomatic tachyarrhythmia (e.g. extra systolic beats); no care changes.\nConcepts: Structure of superior ophthalmic vein (Structure of cavernous sinus)\t3-pyridinecarboxamide, N-(2,3-dihydro-3,3-dimethyl-1H-indol-6-yl)-2-[(4- pyridinylmethyl)amino]- (Protein-tyrosine kinase inhibitor)\tPANSS1-Guilt Feelings (PANSS Clinical Classification Question)\tGrade 1 Neonatal Tachyarrhythmia, AE (Finding)\tREGN 3767 (Immunologic Factor)", + "output": "Grade 1 Neonatal Tachyarrhythmia, AE (Finding)" + }, + { + "input": "Definition: something described as products and technology of land areas, as they affect an individual's outdoor environment through the implementation of land use policies, design, planning and development of space, including those adapted or specially designed.\nConcepts: establishment of protein localization in mitochondrial membrane (establishment of protein localization to membrane)\ttoPositionDimensionThree (Coordinate on an axis or a grid)\tUPD2-Consistency of Rest Tremor (MDS-UPDRS Questionnaire Question)\tProducts and technology of land development (CHAPTER 1 PRODUCTS AND TECHNOLOGY)\ttype 4 neuropeptide Y receptor binding (neuropeptide Y receptor binding)", + "output": "Products and technology of land development (CHAPTER 1 PRODUCTS AND TECHNOLOGY)" + }, + { + "input": "Definition: Finding by site described as symptoms, physical examination results, and/or laboratory test results related to the eye.\nConcepts: FASTENER, PLATE, CRANIOPLASTY (Medical Device)\tSF-MPQ-2 - Tiring-Exhausting (Short-Form MPQ-2 Questionnaire Question)\tLive birth (Pregnancy Outcome)\tLobulus pulmonis (Lobule)\tGeneral visual finding (Finding by site)", + "output": "General visual finding (Finding by site)" + }, + { + "input": "Definition: L-tyrosine aminotransferase activity described as catalysis of the reaction: L-tyrosine + pyruvate = (4-hydroxyphenyl)pyruvate + L-alanine.\nConcepts: 6 Pack (Quantitative Concept)\tGlycoprotein-2, Zona Pellucida (Amino Acid, Peptide, or Protein)\tGreatest Measured Dimension (Quantitative Concept)\tScissors, Surgical, Eye, Extraocular Muscle/Strabismus (Medical Device)\tL-tyrosine:pyruvate aminotransferase activity (Molecular Function)", + "output": "L-tyrosine:pyruvate aminotransferase activity (Molecular Function)" + }, + { + "input": "Definition: Hexosaminidases described as a hexosaminidase with specificity for terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides.\nConcepts: U-body (Cell Component)\tSemen (Male genital fluid)\tendo-N-Acetyl-alpha-D-Galactosamidase (Amino Acid, Peptide, or Protein)\tpositive regulation of cellular response to alcohol (regulation of cellular response to alcohol)\tresponse to IL-1 (Cell Function)", + "output": "endo-N-Acetyl-alpha-D-Galactosamidase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: purine ribonucleoside biosynthetic process described as the chemical reactions and pathways resulting in the formation of xanthosine.\nConcepts: Shigella Biogroup D (Shigella species)\tBlue-Ray Recorders (Physiologic monitoring recorder)\tFocal Spot Size (size)\tPh Negative CML (Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative)\txanthosine formation (xanthosine metabolic process)", + "output": "xanthosine formation (xanthosine metabolic process)" + }, + { + "input": "Definition: Laboratory procedure categorized by method described as to dye or tint tissues or other biological samples for the purpose of imaging structures.\nConcepts: Crassulacean Acid Metabolism Photosynthesis (Physiologic Function)\tSTAINING (tissue/cell preparation)\tUteroplacental Blood Flows (Organ or Tissue Function)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Staphylococcus aureus, DNA (Medical Device)\tSGRQ-C - Not in Control of Respiratory Problems (SGRQ-C Questionnaire Question)", + "output": "STAINING (tissue/cell preparation)" + }, + { + "input": "Definition: something described as a subjective answer of strong agreement.\nConcepts: FAC06238 (FACT-BRM Version 4 Questionnaire Question)\tLACTOFERRIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tVery much (Finding)\tNeonatal dermatomyositis (Autoimmune skin disease)\tIntracellular Communication Inhibition (Intracellular Signaling Process)", + "output": "Very much (Finding)" + }, + { + "input": "Definition: Occupational Activity described as a directive to transcribe the form data into the Comprehensive Data Resource, and record the following information.\nConcepts: necrosis; gallbladder (Gallbladder disorders NEC)\tTranscribe Data into CDR and Record the Following (Occupational Activity)\taberrant RNA catabolic process (Genetic Function)\tMultinodular oncocytic hyperplasia (Pathologic Function)\tPediatric Nurse Specialist (Clinical Nurse Specialists)", + "output": "Transcribe Data into CDR and Record the Following (Occupational Activity)" + }, + { + "input": "Definition: something described as an organization that participates in activities conducted in a framework of a particular clinical trial.\nConcepts: Choriogonadotropin (Hormone measurement)\tNuclear Reactor (Radiation Equipment and Supplies)\tSTENT THROMBOSIS ARC VERY LATE (Academic Research Council Coronary Stent Thrombosis Timing)\tG-protein coupled acetylcholine receptor signaling pathway involved in heart process (G protein-coupled receptor signaling pathway involved in heart process)\tParticipating Study Site (Participating Organization)", + "output": "Participating Study Site (Participating Organization)" + }, + { + "input": "Definition: War described as warfare involving the use of living organisms or their products as disease etiologic agents against people, animals, or plants.\nConcepts: Education about management of symptoms of condition within activity (Educational Activity)\tBIOL WARFARE (Warfare)\tMalignant melanoma of vulva (Neoplastic Process)\tBlindness NOS (Central Nervous System)\tintralobar fissures (Body Space or Junction)", + "output": "BIOL WARFARE (Warfare)" + }, + { + "input": "Definition: something described as unit dose liquid medication dispensers designed to store and deliver the correct single liquid dose needed for an individual patient. These dispensers deliver unit-doses of a liquid medication from a medication container; they may supply a variety of liquid products (e.g. vaccines, biopharmaceuticals). Liquid medication unit-dose dispensers can be manually or power operated. These dispensers are usually made of plastic, metal or a combination of these. They are commonly used at home and at healthcare facilities. Medication dispensers are not usually devices intended for direct administration of medication to patients, they supply the medications and/or medication devices used for administration of medicines.\nConcepts: Lab findings interpretation treatments and procedure (health system management)\tBottle (Potency Unit)\tAssociated Protein, Microtubule (Proteins)\tUnit-Dose Drug Liquid Dispensers (Medical Device)\tblack tea extract (Plant or Plant Part Extract)", + "output": "Unit-Dose Drug Liquid Dispensers (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult Parent Report - In the past one month, how much of a problem has this been for your child: It is hard for my child to explain his or her illness to other people.\nConcepts: Human X Chromosome (Chromosomes, Human, 6-12 and X)\tmammillotectal axonal tract development (anatomical structure development)\tPedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Hard Explain Illness to People (Intellectual Product)\tdihydrofolic reductase activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tFiber product (Pharmacologic Substance)", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Hard Explain Illness to People (Intellectual Product)" + }, + { + "input": "Definition: something described as a recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine hepatocyte growth factor (HGF), which is produced by the liver and the pancreas. Endogenous HGF synthesis is stimulated by injuries affecting liver tissues. This agent, a potent angiogenic and neurotrophic factor and a multifunctional cytokine that acts as a mitogen, motogen and a morphogen, is important for organogenesis and tissue regeneration. Therapeutic HGF has been shown to attenuate brain ischemic injury in animal models through angiogenic and neuroprotective actions.\nConcepts: CAPZA2 wt Allele (Gene or Genome)\tSUSCAT (Classification)\tTic complex (Cell Component)\tmixed acid fermentation (glycolytic fermentation)\tRecombinant Hepatocyte Growth Factor (Pharmacologic Substance)", + "output": "Recombinant Hepatocyte Growth Factor (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as an examination that checks for abnormalities of organs or other structures in the pelvis and lower abdomen. During a digital rectal exam, a health professional inserts a lubricated, gloved finger of one hand into the rectum and may use the other hand to press on the lower abdomen or pelvic area.\nConcepts: LY3143921 Hydrate (Organic Chemical)\t3-carboxymuconate cyclase activity (cyclase activity)\tRECEPT CALCITONIN (Amino Acid, Peptide, or Protein)\tNIMA-Interacting Protein 2 (Biologically Active Substance)\tPalpation, digital, rectal (Diagnostic Procedure)", + "output": "Palpation, digital, rectal (Diagnostic Procedure)" + }, + { + "input": "Definition: WHODAS 2.0 12-item Version Self-administered Questionnaire Question described as world Health Organization Disability Assessment Schedule 2.0 12-item Version Self-administered (WHODAS 2.0 12-item Version Self-administered) In the past 30 days, how much difficulty did you have in: Getting dressed?\nConcepts: WD3S9 (WHODAS 2.0 12-item Version Self-administered Questionnaire Question)\tHypouricaemia (Disorder of purine metabolism)\tALK Rearrangement Analysis Was Not Performed (Testing Was Not Preformed)\tdissociation; interference (Arrhythmia by ECG Finding)\t1p33-p31 (Cell Component)", + "output": "WD3S9 (WHODAS 2.0 12-item Version Self-administered Questionnaire Question)" + }, + { + "input": "Definition: amino acid binding described as interacting selectively and non-covalently with 2-amino-5-(carbamimidamido)pentanoic acid.\nConcepts: arginine binding (cation binding)\tAesculus hippocastanum / white chestnut (Pharmacologic Substance)\tmembrane protein proteolysis (Molecular Function)\tAutocorrelations, Spatial (Spatial Analysis)\tanistreplase (Pharmacologic Substance)", + "output": "arginine binding (cation binding)" + }, + { + "input": "Definition: Communication Barriers described as limited ability to communicate with or understand English.\nConcepts: ADAM15 wt Allele (Gene or Genome)\tLimited English Proficients (Communication Barriers)\tAdductor Group of the Leg (Structure of muscle acting on joint)\tInjury, Crush (Injury or Poisoning)\tStandard weaning infant formula (Food)", + "output": "Limited English Proficients (Communication Barriers)" + }, + { + "input": "Definition: Unit of concentration described as a unit of concentration equal to femtogram per milliliter, divided by kilograms per meter squared.\nConcepts: protein phosphatase 1, regulatory subunit 25 (Helicase Gene)\tCurettes, Dental (Medical Device)\tmcg/day (Unit of Mass Flow Rate)\tfg/mL/(kg/m2) (Quantitative Concept)\tmedium-chain-(S)-2-hydroxy-acid oxidase activity (Molecular Function)", + "output": "fg/mL/(kg/m2) (Quantitative Concept)" + }, + { + "input": "Definition: something described as a classification of maternal and fetal outcomes relating to spontaneous abortions, developed by the Global Alignment of Immunization safety Assessment in pregnancy, based on the extent to which the diagnosis has been confirmed.\nConcepts: Grade 1 Wound Infection, CTCAE (Wound Infection, CTCAE)\tGlobal Alignment of Immunization safety Assessment in pregnancy Spontaneous Abortion Level of Diagnostic Certainty (Intellectual Product)\tTSCC01-Feeling Like Did Something Wrong (Intellectual Product)\tWHODAS 2.0 36-item Version Interviewer-administered - Time Spend on Your Health Condition (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tComputer Time Stamp (Computer Sciences)", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Spontaneous Abortion Level of Diagnostic Certainty (Intellectual Product)" + }, + { + "input": "Definition: WNT Family Protein described as protein Wnt-10b (389 aa, ~43 kDa) is encoded by the human WNT10B gene. This protein plays a role in signaling that modulates pluripotency and cell fate.\nConcepts: cellular response to cisplatin (response to cisplatin)\tWNT-12 protein, human (WNT Family Protein)\tGDS02-Dropped Activities and Interests (Intellectual Product)\tprotein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity (Molecular Function)\tSpecialized Epithelial Cells (Cell)", + "output": "WNT-12 protein, human (WNT Family Protein)" + }, + { + "input": "Definition: something described as progressive spastic paresis, widespread skin pigmentation changes, characteristic facies, and mental retardation in some cases.\nConcepts: Abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology (Anatomical Abnormality)\tcolposcopic biopsy (Biopsy)\tHuman Factors Engineering - Device Difficult to Reprocess (Device Evaluation Conclusion)\tSPASTIC PARAPLEGIA WITH PIGMENTARY ABNORMALITIES (Autosomal recessive hereditary disorder)\tcystic teratoma (Central Nervous System)", + "output": "SPASTIC PARAPLEGIA WITH PIGMENTARY ABNORMALITIES (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: VaccineType described as skin test for tuberculosis using tuberculin, a sterile solution containing growth products of Mycobacterium tuberculosis or Mycobacterium bovis.\nConcepts: SKIN TEST TUBERCULOSIS INTRADERMAL (In-vivo test of susceptibility)\tborane (Chemical Viewed Structurally)\tFLUORESCENCE POLARIZATION IMMUNOASSAY, DIPHENYLHYDANTOIN (Medical Device)\tprotein amino acid nitrosylation (Molecular Function)\tthiamin monophosphokinase activity (Molecular Function)", + "output": "SKIN TEST TUBERCULOSIS INTRADERMAL (In-vivo test of susceptibility)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as an organic N-nitroso compound with possible carcinogenic activity characterized by the group -NNO or -NHNO in its structure, formed by combining nitrates with amines. These compounds are found in various foods and many are carcinogenic or are suspected carcinogens. Cured meats can contain nitrosamines because meats contain amines and can react during cooking with sodium nitrite that is added as a preservative.\nConcepts: PROSTHESIS, WRIST, 2 PART METAL-PLASTIC ARTICULATION, SEMI-CONSTRAINED (Medical Device)\tSphenomaxillary Fossa (Fossa)\tCarcinogenic Nitrosamine (Nitroso Carcinogen)\tChromosome 17p12 (Chromosome band)\t2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide (Histone deacetylase inhibitor)", + "output": "Carcinogenic Nitrosamine (Nitroso Carcinogen)" + }, + { + "input": "Definition: something described as any drugs that are used for their effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.\nConcepts: IgG4-Related Sclerosing Disease (Immune System Diseases)\thsa-let-7 (Nucleotide Sequence)\tDopamine Agents (Antiparkinson Agents)\theart rhythms (Feature of heart rhythm)\tAxonal Dystrophy (Central Nervous System)", + "output": "Dopamine Agents (Antiparkinson Agents)" + }, + { + "input": "Definition: laboratory studies described as specific procedures or audiometric tests used to measure hearing acuity and range in the diagnosis and evaluation of hearing impairments. Consider also AUDIOLOGY and SPEECH AND HEARING MEASURES.\nConcepts: Test;audiometry (Nonoperative procedures related to hearing)\tOncogene, NEU (Gene or Genome)\tStage IIIB Colon Neuroendocrine Tumor AJCC v8 (Neoplastic Process)\tRetinal vasc. occlusion (Disorders of choroid and retina)\tPOG Neuroblastoma Stage B (Pediatric Oncology Group Neuroblastoma Staging System)", + "output": "Test;audiometry (Nonoperative procedures related to hearing)" + }, + { + "input": "Definition: Conducting system of subdivision of heart described as subdivision of conducting system of heart which is located in the muscular part of the interventricular septum and is continuous with the right and left branches of the atrioventricular bundle.\nConcepts: Non- branching part of atrioventricular bundle (Muscular part of interventricular septum proper)\tRETINAL (EYES AND EYE APPENDAGES)\tinositol bisphosphate phosphatase activity (Molecular Function)\tExperimental Organism Benign Mixed Mullerian Tumor (Experimental Organism Neoplasm)\tbrexanolone metabolic process (organic hydroxy compound metabolic process)", + "output": "Non- branching part of atrioventricular bundle (Muscular part of interventricular septum proper)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as transcription factor SOX-8 (446 aa, ~47 kDa) is encoded by the human SOX8 gene. This protein is involved in the activation of transcription.\nConcepts: apocrine; adenoma, breast (Neoplastic Process)\tBreast Cancer Risk Reduction Counseling (Counseling)\tTranscription Factor, SOX-8 (Biologically Active Substance)\tupstream transcription factor 1, human (TRANSCRIPTION FACTOR)\tangstroms (Quantitative Concept)", + "output": "Transcription Factor, SOX-8 (Biologically Active Substance)" + }, + { + "input": "Definition: Disease or Syndrome described as a tropical disease transmitted by mosquito bites\nConcepts: GKAP/SAPAP Interacting Protein (Amino Acid, Peptide, or Protein)\tbeta-solanine rhamnosyltransferase activity (hexosyltransferase activity)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Rubella (Medical Device)\tyellow fever (Yellow Fever)\tNCCN-FACT FBLSI-18 Version 2 - Able to Have, Maintain Erection (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)", + "output": "yellow fever (Yellow Fever)" + }, + { + "input": "Definition: BACTERIA AND RICKETTSIAE described as any bacteria that is not assigned to the species level but can be assigned to the Streptococcus genus level.\nConcepts: ADROIT Electronically Generated Information Service (Software Service)\tInfantile Fibromatosis, Non-Desmoid Type (Fibromatosis)\tSTREPTOCOCCUS (Fastidious bacteria)\tPEDSQL NEUROMUSCULAR MODULE V3 CHILD (Intellectual Product)\t(4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide Mono(5-sulfosalicylate)(Salt) (ANTI-ACNE PREPARATIONS)", + "output": "STREPTOCOCCUS (Fastidious bacteria)" + }, + { + "input": "Definition: something described as the determination of the amount of human papillomavirus 18 antiboy present in a sample.\nConcepts: How much of the time did your caregiving responsibilities make it difficult for you to do your work without stopping to take breaks or rests (Intellectual Product)\t3-oxo-palmitoyl-ACP hydrolase activity (thiolester hydrolase activity)\tSpindle cell rhabdomyosarcoma (Rhabdomyosarcoma)\tpositive regulation of odontogenesis of dentine-containing tooth (positive regulation of odontogenesis)\tHuman Papillomavirus 18 Antibody Measurement (Laboratory Procedure)", + "output": "Human Papillomavirus 18 Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as the process in which the anatomical structures of the metanephric glomerulus vasculature are generated and organized. The metanephric glomerulus vasculature is composed of the tubule structures that carry blood or lymph in the metanephric glomerulus.\nConcepts: Proteins, Carrier (Binding Proteins)\tCochlear malformation (Abnormal cochlea morphology)\tmetanephric glomerulus vasculature morphogenesis (glomerulus vasculature morphogenesis)\tDental occlusal splint (Splint Device)\tResident (Persons)", + "output": "metanephric glomerulus vasculature morphogenesis (glomerulus vasculature morphogenesis)" + }, + { + "input": "Definition: Anabolism described as the chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.\nConcepts: 3q21.2 (Chromosome band)\thormone synthesis (Molecular Function)\tdemyelinating disorders (Degenerative disorder)\tSelf-Evaluations (Mental Process)\tOpioid Receptors, delta (Amino Acid, Peptide, or Protein)", + "output": "hormone synthesis (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as alpha-numeric character(s) assigned by the sponsor to identify a particular collection of subjects possessing common characteristic(s).\nConcepts: INCLUSION (cellular anatomical entity)\tInvestigational Product Site Release Document (Document type)\tUnresectable Ureter Urothelial Carcinoma (Unresectable Renal Pelvis and Ureter Urothelial Carcinoma)\tAllergic conjunctivitis (Hypersensitivity)\tSponsor Defined Group Code (Intellectual Product)", + "output": "Sponsor Defined Group Code (Intellectual Product)" + }, + { + "input": "Definition: something described as a series of molecular signals initiated by the binding of interleukin-15 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.\nConcepts: Hypermanganesemia with dystonia 2 (Disease or Syndrome)\tretroviral integrase activity (Molecular Function)\tIL-15-mediated signaling pathway (cytokine-mediated signaling pathway)\tVomiting, Anticipatory (Anticipatory Nausea and Vomiting)\tindoximod (Amino Acid, Peptide, or Protein)", + "output": "IL-15-mediated signaling pathway (cytokine-mediated signaling pathway)" + }, + { + "input": "Definition: Contrast Media described as a fluorescently quenched, cysteine cathepsin-cleavable near infrared (NIR) substrate probe containing the dye indocyanine green (ICG), that may be used for cancer imaging purposes using an NIR imaging system. In 6QC-NIR, the cathepsin-activatable fluorescent probe contains the fluorophore, ICG, linked, via a cathepsin protease cleavable peptide, with a core Cbz-Phe-Lys peptide sequence, to a fluorescent quencher, QC-1. Upon administration of 6QC-NIR, the amide bond of the peptide can be cleaved by cathepsin proteases overexpressed by tumor cells and highly abundant in the tumor microenvironment (TME). Upon proteolysis, the quencher is released, the fluorophore becomes activated and accumulates in the lysosome. Upon clinical NIR imaging, using the da Vinci Si surgical system, tumor cells expressing cathepsin family proteases can be detected which allows for visualization of the tumor.\nConcepts: 6QCICG (Organic Chemical)\tAttributable, Legible, Contemporaneous, Original, Accurate (Guidelines)\tHyaluronic Acid Measurement (Chemical procedure)\tOrthodontic appliances, Extraoral traction (Removable Orthodontic Appliances)\tfall prevention (Therapeutic or Preventive Procedure)", + "output": "6QCICG (Organic Chemical)" + }, + { + "input": "Definition: Bioactive Food Component described as inorganic material remaining after incineration of a food substance.\nConcepts: Notched outermost bone of the ring finger (Anatomical Abnormality)\tDietary Ash (Bioactive Food Component)\tSubclavian lymphatic tree (Body Part, Organ, or Organ Component)\tMT (Mediterranean Islands)\tANTISERA, NEUTRALIZATION, PARAINFLUENZA VIRUS 1-4 (Indicator, Reagent, or Diagnostic Aid)", + "output": "Dietary Ash (Bioactive Food Component)" + }, + { + "input": "Definition: rubredoxin-NAD(P)+ reductase activity described as catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+.\nConcepts: rubredoxin-NADP reductase activity (Molecular Function)\tAngiogenesis Inducers (Angiogenesis Modulating Agents)\tNon-Contiguous Follicular Mixed Cell Lymphoma Stage II (Neoplastic Process)\tapsac (Enzyme)\tPeperomias (Plant)", + "output": "rubredoxin-NADP reductase activity (Molecular Function)" + }, + { + "input": "Definition: Clinical Drug described as himalaya ProSelect(TM) Mentat JR 120, 490 mg tablets. UPC Code 605069106214.\nConcepts: himalaya proselect mentat jr (Nutraceuticals)\tfixative (Specialty Uses of Chemicals)\ttrans-feruloyl-CoA hydro-lyase activity (Molecular Function)\tmantle cell lymphoma stage III (B-cell lymphoma stage III)\tPrenatal Development (Organism Function)", + "output": "himalaya proselect mentat jr (Nutraceuticals)" + }, + { + "input": "Definition: something described as the human MIR516A1 wild-type allele is located in the vicinity of 19q13.41 and is approximately 89 bases in length. This allele, which encodes MIR516A1 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with development of breast cancer.\nConcepts: Elevated diastolic blood pressure (Vascular)\tHomogeneous Fat Echotexture (Image Feature)\thigh-density lipoprotein particle remodeling (plasma lipoprotein particle remodeling)\tGastric Dilatation (Parasympatholytics)\tMIRN516A1 (Gene or Genome)", + "output": "MIRN516A1 (Gene or Genome)" + }, + { + "input": "Definition: Pathologic Function described as a process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse.\nConcepts: electronic stimulator (Medical Device)\tTesticle Implants (Medical Device)\tmelilotate dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tDrug Kit (Package Type)\tMuscular atrophy (striated muscle atrophy)", + "output": "Muscular atrophy (striated muscle atrophy)" + }, + { + "input": "Definition: something described as moderate pain; Erythema 5.1-10 cm; Induration/swelling 5.1-10 cm; lipodystrophy; limiting instrumental ADL\nConcepts: Organization Relationship Type Code (Type Code)\tHemangioma of Peripheral Nerve (Peripheral Nervous System Neoplasms)\tE2F-5 (E2F5 gene)\tCerebral vasoconstriction syndrome (Disease or Syndrome)\tGrade 2 Vaccination Complication, CTCAE (Vaccination Complication, CTCAE)", + "output": "Grade 2 Vaccination Complication, CTCAE (Vaccination Complication, CTCAE)" + }, + { + "input": "Definition: Transcription Factors, General described as transcription initiation factor TFIID subunit 10 (218 aa, ~22 kDa) is encoded by the human TAF10 gene. This protein is involved in both histone acetylation and transcription initiation.\nConcepts: hTAFII30 protein, human (Amino Acid, Peptide, or Protein)\tAnatomical junction (Body Regions)\tVaricella zoster IgM level (Laboratory Procedure)\tEGFR c.2309 2310AC>CCAGCGTGGAT (Cell or Molecular Dysfunction)\tNormally split S2 (Finding)", + "output": "hTAFII30 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as tree moss.\nConcepts: BPRSA1-Unusual Thought Content (Intellectual Product)\tAcute Renal Insufficiencies (Acute nephropathy)\tusnea barbata/tree moss (Organic Chemical)\t(+)-lariciresinol metabolism (ether metabolic process)\tcerebellar molecular layer development (anatomical structure development)", + "output": "usnea barbata/tree moss (Organic Chemical)" + }, + { + "input": "Definition: Clinical Trials described as post approval studies to delineate additional information about the drug's risks, benefits, and optimal use that may be requested by regulatory authorities in conjunction with marketing approval. NOTE: These studies could include, but would not be limited to, studying different doses or schedules of administration than were used in Phase 2 studies, use of the drug in other patient populations or other stages of the disease, or use of the drug over a longer period of time.\nConcepts: Biology of Aging (Biomedical Occupation or Discipline)\tclinical trial phase IV (Product Surveillance, Postmarketing)\tCTLA-4 Probody BMS-986249 (Antineoplastic Antibody)\tdefibrillator/cardioverters (Medical Devices)\tRacotumomab (Anti-Idiotype Vaccine)", + "output": "clinical trial phase IV (Product Surveillance, Postmarketing)" + }, + { + "input": "Definition: positive regulation of epithelial cell differentiation involved in kidney development described as any process that activates or increases the frequency, rate or extent of nephron tubule epithelial cell differentiation.\nConcepts: positive regulation of nephron tubule epithelial cell differentiation (positive regulation of epithelial cell differentiation involved in kidney development)\tAdsorption (Physical Phenomena)\tNephrotic Syndrome - ANLN Associated (Nephrotic Syndrome)\tAbnormality of the cerebellar vermis (Cerebellar malformation)\tN-terminal peptidyl-valine deamination (N-terminal protein amino acid deamination, from amino carbon)", + "output": "positive regulation of nephron tubule epithelial cell differentiation (positive regulation of epithelial cell differentiation involved in kidney development)" + }, + { + "input": "Definition: 2-oxoglutarate-dependent dioxygenase activity described as catalysis of the reaction: 2-oxoglutarate + deacetoxycephalosporin C + O(2) = CO(2) + deacetylcephalosporin C + succinate.\nConcepts: deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity (Molecular Function)\tIPAQ Long Last 7 Days Telephone Format Version - Sitting Hours on Saturday (Intellectual Product)\tMagnesium Hydroxide/Aluminum Hydroxide/Simethicone Suspension (Antacids)\tdentists examination/treatment chairs (Examination/treatment chair)\tThoracic Spine Neoplasm (Spinal Neoplasms)", + "output": "deacetoxycephalosporin-C,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity (Molecular Function)" + }, + { + "input": "Definition: PSYCHOSOCIAL DOMAIN described as providing support, nurturance, stimulation, and physical care for dependent child or adult.\nConcepts: Caretaking/parenting (Social Behavior)\tTimopentina (T [Preparations])\tAVL01113 (Intellectual Product)\tHeart-Wall Motion Cardiographs (Medical Device)\tADL01-Keep Appointments (ADCS-ADL Questionnaire Question)", + "output": "Caretaking/parenting (Social Behavior)" + }, + { + "input": "Definition: Intellectual Disability described as mental and growth deficiency, nail onychodysplasia or aplasia (usually of the fifth finger or toe), short distal phalanges, coarse facies (usually bushy eyebrows, scant scalp hair, full lips, and microcephaly, and other abnormalities.\nConcepts: PODCI2-Have Pain Relief (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tHYPERTRICHOSIS, HYPERKERATOSIS, MENTAL RETARDATION, AND DISTINCTIVE FACIAL FEATURES (Multisystem disorder C-D)\tUCHL2 Gene Mutation (Cell or Molecular Dysfunction)\tSorbitol dehydrogenase measurement (Laboratory Procedure)\tStatisticalAnalysisPlanVersion.typeCode (Intellectual Product)", + "output": "HYPERTRICHOSIS, HYPERKERATOSIS, MENTAL RETARDATION, AND DISTINCTIVE FACIAL FEATURES (Multisystem disorder C-D)" + }, + { + "input": "Definition: something described as aplastic anemia without a known cause.\nConcepts: Early-onset dystonia parkinsonism (Hereditary disorder of nervous system)\tBGR (Southeastern Europe)\tneurotransmitter receptor localisation in postsynaptic specialization membrane (protein localization to postsynaptic specialization membrane)\tPrenatal (patient care)\tanemia; aplastic, idiopathic (Disease or Syndrome)", + "output": "anemia; aplastic, idiopathic (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell.\nConcepts: Female pelvic inflammatory diseases NOS (Diagnosis/Diseases Component)\tHADS0113 (HADS Questionnaire Question)\tT cell receptor signaling pathway (Signal Transduction Pathways)\tZinc-DTPA (Organic Chemical)\tFoetal megacystis (Congenital genitourinary tract anomalies NEC)", + "output": "T cell receptor signaling pathway (Signal Transduction Pathways)" + }, + { + "input": "Definition: Philadelphia chromosome positive chronic myelogenous leukemia described as the initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.\nConcepts: EMERGENCY MED (Medical Specialities)\tcytokinin binding (Molecular Function)\tmicroRNA 518e (MicroRNA Gene)\tChronic Phase CML (Neoplastic Process)\tDressings, Nonimpregnated, Natural Fiber, Cotton/Gauze, Fluff (Medical Device)", + "output": "Chronic Phase CML (Neoplastic Process)" + }, + { + "input": "Definition: Gene or Genome described as human ROBO1 wild-type allele is located in the vicinity of 3p12 and is approximately 1170 kb in length. This allele, which encodes roundabout homolog 1 protein, plays a role in both axon guidance and neuroblast migration.\nConcepts: Wautersia Vaneechoutte et al. 2004 (Burkholderiaceae)\tFeeling tired or having little energy (Intellectual Product)\tFollicular [nodular] non-Hodgkin's lymphoma (Lymphoma, Diffuse)\tDUTT1 (ROBO1 gene)\thatching (Organism Function)", + "output": "DUTT1 (ROBO1 gene)" + }, + { + "input": "Definition: Extracranial Neuroblastoma described as a malignant olfactory neuroblastoma arising from the olfactory epithelium of the superior nasal cavity and cribriform plate. It is uncommon (3% of nasal tumors) and rarely is associated with the production of excess hormones (e.g., SIADH, Cushing Syndrome). It has a high propensity for multiple local recurrences and bony metastases. (From Holland et al., Cancer Medicine, 3rd ed, p1245; J Laryngol Otol 1998 Jul;112(7):628-33)\nConcepts: CRKRS Gene Mutation (Cell or Molecular Dysfunction)\tantimonite transmembrane transporter activity (Molecular Function)\tglutamate breakdown to 2-oxoglutarate (2-oxoglutarate metabolic process)\tEsthesioneuroblastoma of the Accessory Sinus (Malignant neuroendocrine neoplasm, neural)\toptineurin protein, human (Amino Acid, Peptide, or Protein)", + "output": "Esthesioneuroblastoma of the Accessory Sinus (Malignant neuroendocrine neoplasm, neural)" + }, + { + "input": "Definition: polymeric cytoskeletal fiber described as fibers composed of MICROFILAMENT PROTEINS, which are predominately ACTIN. They are the smallest of the cytoskeletal filaments.\nConcepts: Cytoskeleton, Actin (Cell Component)\tnew guinea (Melanesia)\trequest for proposal (Funding Opportunities)\tPDLIM2 wt Allele (PDLIM2 gene)\tRhabdoid Neoplasm of the Kidney (Kidney Neoplasm)", + "output": "Cytoskeleton, Actin (Cell Component)" + }, + { + "input": "Definition: Vitamins described as a nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Vitamin B1 helps some enzymes work properly, helps break down sugars in the diet, and keeps nerves and the heart healthy. It is found in pork, organ meats, peas, beans, nuts, and whole grains. Vitamin B1 is water-soluble (can dissolve in water) and must be taken in daily. Not enough vitamin B1 can cause a disease called beriberi (a condition marked by heart, nerve, and digestive disorders). Too much vitamin B1 may help cancer cells grow faster.\nConcepts: thiamine(1+) (Vitamins)\tO-6-Methylguanine-DNA Methyltransferase wt Allele (Gene or Genome)\tCD6 antigen (Cell Adhesion Molecule Gene)\tEXACT1-Chest Feel Tight (EXACT Questionnaire Question)\tregulation of nephron tubule epithelial cell differentiation (Cell Function)", + "output": "thiamine(1+) (Vitamins)" + }, + { + "input": "Definition: something described as serine/threonine-protein kinase 3 (491 aa, ~56 kDa) is encoded by the human STK3 gene. This protein plays a role in the mediation of both protein phosphorylation and signaling.\nConcepts: Dicarbomethoxyzinc (Acetates)\tMANGO SEED OIL (Natural Products)\tMammalian STE20-Like Protein Kinase 2 (Protein-Serine-Threonine Kinases)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child - Feel Tired (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)\tPwd (SolidDrugForm)", + "output": "Mammalian STE20-Like Protein Kinase 2 (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Digestive System Disorders, General, Functional and NEC described as vomiting blood.\nConcepts: Chronic uveitis or iridocyclitis (eyes and vision)\tnegative regulation of interleukin-14 synthesis (Cell Function)\tVomiting of blood (Hemorrhage)\tStress Level (Finding)\tNecrotizing enterocolitis in fetus OR newborn (Korean Standard Classification of Disease Version 5)", + "output": "Vomiting of blood (Hemorrhage)" + }, + { + "input": "Definition: nitrogen cycle metabolic process described as the nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.\nConcepts: Fluorescence (Microscopy technique)\tTip of posterior nasal spine (Body Location or Region)\tStructure of precentral sulcus (Body Space or Junction)\tHLA-DP HISTOCOMPATIBILITY TYPE, BETA-1 SUBUNIT (Gene or Genome)\tnitrate assimilation (Cell Function)", + "output": "nitrate assimilation (Cell Function)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the ability of the translational apparatus to interpret the genetic code.\nConcepts: FAC03002 (NCCN-FACT FBRSI-24 Version 2 Questionnaire Question)\tWashing whole body (Washing oneself)\tregulation of translational fidelity (regulation of biological quality)\tdelphinium (Delphinieae)\t4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid (Organic Chemical)", + "output": "regulation of translational fidelity (regulation of biological quality)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as facial onset sensory and motor neuronopathy is characterized initially by paresthesia and numbness in the region of the trigeminal nerve distribution, which later progresses to involve the scalp, neck, upper trunk and upper limbs. Onset of motor manifestations occurs later with cramps, fasciculations, dysphagia, dysarthria, muscle weakness and atrophy. This syndrome has been described in four males and appears to be a slowly progressive neurodegenerative disease.\nConcepts: BDI01TN (Intellectual Product)\tpositive regulation of cell adhesion molecule production (regulation of cell adhesion molecule production)\tYes (Finding)\tFOSMN (facial onset sensory and motor neuronopathy) syndrome (Degenerative Diseases, Central Nervous System)\tBacillus (Bacteria)", + "output": "FOSMN (facial onset sensory and motor neuronopathy) syndrome (Degenerative Diseases, Central Nervous System)" + }, + { + "input": "Definition: something described as life Events Checklist for DSM-5, Standard Version - Any other very stressful event or experience: Not sure.\nConcepts: POV1 (SLC43A1 gene)\tprotein processing in phagocytic vesicle (Post-Translational Protein Processing)\tLEC-5 Standard Version - Other Stressful Event: Not Sure (LEC-5 Standard Version Questionnaire Question)\tDisruptive vocalization (Finding)\tRomantic relationships (Social Behavior)", + "output": "LEC-5 Standard Version - Other Stressful Event: Not Sure (LEC-5 Standard Version Questionnaire Question)" + }, + { + "input": "Definition: Eukaryote described as a class in the phylum MOLLUSCA comprised of mussels; clams; OYSTERS; COCKLES; and SCALLOPS. They are characterized by a bilaterally symmetrical hinged shell and a muscular foot used for burrowing and anchoring.\nConcepts: Pelecypoda (Mollusca)\tExtreme Right Axis Deviation (Electrocardiogram finding)\tursolic aldehyde 28-monooxygenase activity (Molecular Function)\tOrbital Contusion (Finding)\tPeripheral ICC (Intrahepatic Cholangiocarcinoma)", + "output": "Pelecypoda (Mollusca)" + }, + { + "input": "Definition: something described as a measurement of the Y1 subunit of glutathione-s-transferase in a biological specimen.\nConcepts: 1-dimethylcarbamoyl-2-methyl-4-pyrazolyl dimethylcarbamate (Acetylcholinesterase Inhibitors)\tIVD Panels, Human Genetics, Encephalopathy, Rett Syndrome/Angelman Syndrome (IVD Panels, Human Genetics, Encephalopathy)\tM\u00e9loxicam (Nitrogen and nitrogen compound)\tGlutathione S-Transferase Y1 Subunit Measurement (Protein or Enzyme Type Measurement)\t\u03b2-L-2'-deoxythymidine (Nucleoside Reverse Transcriptase Inhibitor)", + "output": "Glutathione S-Transferase Y1 Subunit Measurement (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: something described as human NEUROG1 wild-type allele is located within 5q23-q31 and is approximately 2 kb in length. This allele, which encodes neurogenin-1 protein, is involved in both transcriptional regulation and neuronal differentiation.\nConcepts: Heparan Sulfate Glycosaminoglycan Mimetic Nanopolymer Mouthwash (Protective Agents)\tWHIVS2 (Intellectual Product)\tinternist (Medical Occupation)\tBHLHA6 (NEUROG1 gene)\tPeroxisome Targeting Signal 1 (Amino Acid Sequence)", + "output": "BHLHA6 (NEUROG1 gene)" + }, + { + "input": "Definition: Bronchi described as a specimen that contains lung and bronchial tissues.\nConcepts: Echiums (Boraginaceae)\tBronchus and lung (Bronchi)\tSkeletons (Skeletal bone)\tMFN2 wt Allele (MFN2 gene)\tDistal Bile Duct Cancer pT0 TNM Finding v7 (Distal Bile Duct Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Bronchus and lung (Bronchi)" + }, + { + "input": "Definition: oncology field described as the study of the cellular changes associated with the development of neoplastic conditions.\nConcepts: Cellular Oncology (oncology field)\tSystemic vascular resistance (Cardiovascular finding)\tmalnutrition children (Disease or Syndrome)\tProlonged yellowing of skin in newborn (Liver)\tendothelial tissue (Tissue)", + "output": "Cellular Oncology (oncology field)" + }, + { + "input": "Definition: something described as initial concentration divided by the surface area. Given only for bolus IV models.\nConcepts: Initial Conc Norm by SA (Quantitative Concept)\tchitin oligosaccharide deacetylase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tIndirect fundoscopy (Diagnostic Procedure)\tstraight chain (R)-2-hydroxy fatty acyl-CoA lyase activity (Molecular Function)\tRhaphidophora (Plant)", + "output": "Initial Conc Norm by SA (Quantitative Concept)" + }, + { + "input": "Definition: Medical Device described as an acetaminophen test system is a device intended to measure acetaminophen, an analgestic and fever reducing drug, in serum. Measurements obtained by this device are used in the diagnosis and treatment of acetaminophen overdose.\nConcepts: Religion (Humanities)\tCOLORIMETRY, ACETAMINOPHEN (Medical Device)\tStartle-induced seizure (Disease or Syndrome)\tPolyomaviridae (Sepolyvirales)\tVEILLONELLA DISPAR (Bacterium)", + "output": "COLORIMETRY, ACETAMINOPHEN (Medical Device)" + }, + { + "input": "Definition: Non-infectious pericarditis described as inflammation of the PERICARDIUM that is characterized by the fibrous scarring and adhesion of both serous layers, the VISCERAL PERICARDIUM and the PARIETAL PERICARDIUM leading to the loss of pericardial cavity. The thickened pericardium severely restricts cardiac filling. Clinical signs include FATIGUE, muscle wasting, and WEIGHT LOSS.\nConcepts: Nasal Cavity and Ethmoid Sinus Cancer Pathologic Primary Tumor TNM Finding v6 (Finding)\tOTRCUPCN (Diagnostic Procedure)\tCrop, Avian (Esophageal part)\tConstrictiv pericarditis (Pericarditis, Constrictive)\tStippling of the epiphyses of the phalanges of the hand (Abnormal hand bone ossification)", + "output": "Constrictiv pericarditis (Pericarditis, Constrictive)" + }, + { + "input": "Definition: something described as mono-ADP-ribosyltransferase sirtuin-6 (355 aa, ~ 39 kDa) is encoded by the human SIRT6 gene. This protein may be involved in post-translational protein modification.\nConcepts: Study Subject Digital Photos Report (Report)\tEpithelium of pulmonary alveolus (Tissue)\tVitros ECi (Instrument - device)\tSirtuin 6 (Amino Acid, Peptide, or Protein)\tManuscripts (Intellectual Product)", + "output": "Sirtuin 6 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the ditosylate salt of lapatinib, a synthetic, orally-active quinazoline with potential antineoplastic activity. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts. EGFR and ErbB2 have been implicated in the growth of various tumor types.\nConcepts: phytanoyl-CoA 2-hydroxylase activity (Molecular Function)\tSulfonate, Polyanethol (Polymers)\tLapatinib ditosylate (Protein-tyrosine kinase inhibitor)\tkallmans syndrome (46, XY Disorders of Sex Development)\tL-idonate synthesis (aldonic acid biosynthetic process)", + "output": "Lapatinib ditosylate (Protein-tyrosine kinase inhibitor)" + }, + { + "input": "Definition: something described as the proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands.\nConcepts: Product containing sodium citrate (Pharmacologic Substance)\tneonatal; neutropenia (Neonatal disease due to placental transfer of antibody)\tCholedochal Cysts, Diverticulum (Congenital Abnormality)\tMNSI - Physical Assessment Total Score (MNSI Questionnaire Question)\tconstitutive protein ectodomain proteolysis (Molecular Function)", + "output": "constitutive protein ectodomain proteolysis (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as apoptosis regulator Bcl-2 (239 aa, ~26 kDa) is encoded by the human BCL2 gene. This protein plays a role in cellular survival.\nConcepts: Melanoma of Adult Leptomeninges (Adult Primary Melanocytic Lesion of Meninges)\tpeptide crotonyltransferase activity (Molecular Function)\tB-cell CLL-lymphoma 2 protein, human (Apoptosis Regulatory Proteins)\tFrontal venous angioma (Congenital Abnormality)\ttransmembrane transport (Biological Transport)", + "output": "B-cell CLL-lymphoma 2 protein, human (Apoptosis Regulatory Proteins)" + }, + { + "input": "Definition: something described as lymphocytes responsible for cell-mediated immunity, formed when lymphocytes circulate through the thymus gland and differentiate to thymocytes; when exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.\nConcepts: Chromosome 16p11.2 Deletion Syndrome (Syndrome)\tPODCI290 (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tPimenta officinalis / sweet spicy clove (Organic Chemical)\tCell, T (Other markers)\tbA165P4.1 (CNTRL gene)", + "output": "Cell, T (Other markers)" + }, + { + "input": "Definition: Recurrent Childhood Astrocytic Tumor described as the reemergence of anaplastic astrocytoma in childhood after a period of remission.\nConcepts: recurrent childhood anaplastic astrocytoma (Neoplastic Process)\tBRAF/RAF1 Dimer (Laboratory or Test Result)\tregulation of relaxation of muscle in other organism (regulation of relaxation of muscle)\tcellular response to low light intensity stimulus (response to low light intensity stimulus)\tGrade 2 Pulmonary Valve Disease, CTCAE (Pulmonary Valve Disease, CTCAE)", + "output": "recurrent childhood anaplastic astrocytoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as soft tissue sarcoma with deep tumor measuring 5 cm or less in greatest dimension.\nConcepts: Bone anchored fixture (Bone-conduction hearing aid)\tSoft Tissue Sarcoma pT1b TNM Finding v7 (Finding)\tRetinoblastoma Pathologic Distant Metastasis TNM Finding v7 (Retinoblastoma Pathologic TNM Finding v7)\t4-isothioureidobutyronitrile (Pharmacologic Substance)\tregulation of cyclodextrin metabolic process (Cell Function)", + "output": "Soft Tissue Sarcoma pT1b TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Statistical Technique described as the substitution of some value for a missing data point or a missing component of a data point.\nConcepts: Impute (Statistical Technique)\tBLCS01-Bladder Restricted Lifestyle (Intellectual Product)\tGlutamates (Excitatory Amino Acids)\tTimed Up and Go Test Functional Test Test Name (CDISC Functional Test Terminology)\tDisease Response Assessment Test (Intellectual Product)", + "output": "Impute (Statistical Technique)" + }, + { + "input": "Definition: Benign Outer Hair Sheath and Infundibulum Neoplasm described as a cutaneous adnexal neoplasm with variable clinical presentation. It tends to be located in the head and neck and the presentation is papulonodular, scaly, asymptomatic, measuring up to 1-2cm, simulating a basal cell carcinoma.\nConcepts: Benign tumor of follicular infundibulum (Neoplastic Process)\tUterine Manipulators (Urogenital device)\tParaflutizide (Thiazide Diuretics)\tBusiness Entity Qualifier (Intellectual Product)\tOcimum (Ocimeae)", + "output": "Benign tumor of follicular infundibulum (Neoplastic Process)" + }, + { + "input": "Definition: Anatomical Abnormality described as this term applies if one or more of the phalanges of the hand are either partially duplicated, depending on severity leading to a broad or bifid appearance of the phalanges, or completely duplicated.\nConcepts: MCL Gene Mutation (Gene Mutant)\tEthane-1-hydroxy-1,1-diphosphonic acid (Organic Chemical)\tQLES188 (Intellectual Product)\tDuplication of phalanx of hand (Duplication of hand bones)\tLyme Disease (Other specified arthropod-borne diseases, other)", + "output": "Duplication of phalanx of hand (Duplication of hand bones)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Summary score for ideational praxis.\nConcepts: SYSTEM, READING, TELEVISION, CLOSED-CIRCUIT (Medical Device)\tglutamate degradation to oxaloacetate (dicarboxylic acid biosynthetic process)\tgenerative cell mitosis (mitotic nuclear division)\tCongenital muscular dystrophy type 1B (Disease or Syndrome)\tADCIP (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "ADCIP (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: Catalase-negative Gram-positive coccus described as any bacteria that is not assigned to the species level but can be assigned to the Aerococcus genus level.\nConcepts: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (Molecular Function)\tAEPATT (Qualitative Concept)\t109 AEROCOCCUS (Catalase-negative Gram-positive coccus)\tCytodiagnoses (Cytological Techniques)\tnucleoside ribosyltransferase activity (pentosyltransferase activity)", + "output": "109 AEROCOCCUS (Catalase-negative Gram-positive coccus)" + }, + { + "input": "Definition: Accounting described as accounting procedures for determining credit status and methods of obtaining payment.\nConcepts: CREDIT COLLECTION PATIENT (Accounting)\tprimary active transmembrane transporter activity (Molecular Function)\taminotriazole transmembrane transporter activity (azole transmembrane transporter activity)\tMembrane, Mucous (integumentary system: general terms)\t/mL (Unit of Arbitrary Substance Concentration)", + "output": "CREDIT COLLECTION PATIENT (Accounting)" + }, + { + "input": "Definition: something described as this gene is involved in the regulation of diverse cell processes including cell growth, proliferation, differentiation and motility.\nConcepts: patched homolog 2 (Gene or Genome)\tOvarian Wilms Tumor (Nephroblastoma)\tPROTEIN KINASE A, C-ALPHA SUBUNIT (Serine/Threonine Protein Kinase Gene)\tTomographic Optical Breast Imaging (Breast Imaging Study)\tleukocyte adherence inhibition test (Laboratory Procedure)", + "output": "PROTEIN KINASE A, C-ALPHA SUBUNIT (Serine/Threonine Protein Kinase Gene)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 3p\nConcepts: neurogenic diabetes insipidus (ENDOCRINE FEATURES)\t3p25.3 (Chromosome band)\tVaginal Adenoid Basal Carcinoma (Vagina Carcinoma)\tDeath in infancy (Finding)\tDesmoplastic Ameloblastoma (Neoplastic Process)", + "output": "3p25.3 (Chromosome band)" + }, + { + "input": "Definition: Occipital lobe described as a variable multibranched groove on the dorsolateral aspect of the occipital lobe of the human ( Duvernoy-1992 ). In some brains it is continuous with the intraparietal sulcus rostrally ( Ono-1990 ). It is not found in the macaque nor in the smooth cerebral cortex of the rat or mouse ( NeuroNames ). See also occipital place area.\nConcepts: EthnicityHispanicCentralAmerican (Hispanics)\tpositive regulation of zygosporangium development (regulation of zygosporangium development)\tDoppler Flow Mapping Systems (Scanning Systems)\tHypoplastic clitoris (Finding)\tSulcus occipitalis transversus (Occipital lobe)", + "output": "Sulcus occipitalis transversus (Occipital lobe)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O.\nConcepts: Charting patient information (GENERAL CARE NURSING PROCEDURES)\tdesmolase, steroid 20-22 (steroid hydroxylase activity)\t4 OF 5 (Clinical or Research Assessment Answer)\tRADIODEN (density)\tHCV DNA Vaccine INO-8000 (Cancer Vaccines)", + "output": "desmolase, steroid 20-22 (steroid hydroxylase activity)" + }, + { + "input": "Definition: Intradermal Route of Drug Administration described as administration within the dermis.\nConcepts: Replication Origins (Replicon)\tExternal ear malformation (Abnormal ear morphology)\tEndothelin B Receptor Agonist SPI-1620 (Pharmacologic Substance)\tID (parenteral administration)\tIfex/Mesnex/Taxol (Regimen Used to Treat Malignant Peritoneal Neoplasm)", + "output": "ID (parenteral administration)" + }, + { + "input": "Definition: something described as geriatric Depression Scale Short Form - Do you often get bored?\nConcepts: detection of temperature (detection of abiotic stimulus)\tGDS-SF - Often Get Bored (Intellectual Product)\tRNA Binding Proteins (Nucleoproteins)\tCHARCOT-MARIE-TOOTH DISEASE, TYPE 4A (Disease or Syndrome)\tregulation of RNA metabolic process (regulation of macromolecule metabolic process)", + "output": "GDS-SF - Often Get Bored (Intellectual Product)" + }, + { + "input": "Definition: Receptor Binding described as interacting selectively and non-covalently with an opioid receptor.\nConcepts: OABQ01-Nighttime Urination (OAB-q Questionnaire Question)\tTrophic changes (Finding)\tdown regulation of synapse structural plasticity (Organ or Tissue Function)\topioid receptor binding (Receptor Binding)\tcyclin B1-CDK1 complex (Cell Component)", + "output": "opioid receptor binding (Receptor Binding)" + }, + { + "input": "Definition: peptidyl-serine modification described as the chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation.\nConcepts: peptide cross-linking via L-cysteine oxazolecarboxylic acid (peptidyl-cysteine modification)\tIatrogenic Botulism (Disease or Syndrome)\tOvarian Cancer and Primary Peritoneal Carcinoma pNX TNM Finding v7 (Ovarian Cancer and Primary Peritoneal Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7)\tCaspase-Independent Apoptosis (Molecular Function)\tConfidence Scale (Intellectual Product)", + "output": "peptide cross-linking via L-cysteine oxazolecarboxylic acid (peptidyl-cysteine modification)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Does the patient have hallucinations such as seeing false visions or hearing false voices? Does he/she seem to see, hear or experience things that are not present? By this question we do not mean just mistaken beliefs such as stating that someone who has died is still alive; rather we are asking if the patient actually has abnormal experiences of sounds or visions.\nConcepts: B cell programmed cell death by apoptosis (Lymphocyte Apoptotic Process)\tStage IVB Thymoma AJCC v8 (Neoplastic Process)\tSERUM, HORSE (Reagents)\tMicroRNA 138-2 wt Allele (Gene or Genome)\tNPI1B (NPI Questionnaire Question)", + "output": "NPI1B (NPI Questionnaire Question)" + }, + { + "input": "Definition: Pharmacologic Substance described as any agent that targets FGFR.\nConcepts: FGFR-targeting Agent (Pharmacologic Substance)\tadenosine 3',5'-cyclophosphate binding (anion binding)\tFCORD2B (Disease or Syndrome)\tLicensing Factor (DNA Replication Initiation Protein)\tPatient Alert (General Qualifier)", + "output": "FGFR-targeting Agent (Pharmacologic Substance)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as couinaud segment VI, corresponding to the posterior segment of the right lobe of the liver, located inferiorly.\nConcepts: Barber Surgeons (History of Medicine)\tVisionblue (Organic Chemical)\tTNRC9 (TOX3 gene)\tContractor (Population Group)\tCouinaud Segment VI (Couinaud liver segment)", + "output": "Couinaud Segment VI (Couinaud liver segment)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the aristaless related homeobox (ARX) gene, located at chromosome Xp21.3, which encodes the homeobox protein ARX. Genetic variants at this locus have been associated with early infantile epileptic encephalopathy 1, X-linked lissencephaly 2, X-linked ARX-related mental retardation with or without seizures, Partington X-linked mental retardation syndrome, and Proud Levine Carpenter syndrome.\nConcepts: Consensus (Property or Attribute)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ARX (Medical Device)\tmol/l/(kg/m2) (Quantitative Concept)\tPectoralis major hypoplasia (Finding)\t(1R,2R,4S)-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R,trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-1-naphthacenecarboxylic acid methyl ester (Antibiotic)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ARX (Medical Device)" + }, + { + "input": "Definition: CDISC Clinical Classification Terminology described as the Brief Psychiatric Rating Scale-A test code.\nConcepts: SSTR4 (Gene or Genome)\tBreast carcinoma inflammatory (Breast Carcinoma)\tFAC023-Problem Urinating Limits Activity (FACT-P Version 4 Questionnaire Question)\tBPRSA1TC (CDISC Clinical Classification Terminology)\tcorticotropin receptor activity (Molecular Function)", + "output": "BPRSA1TC (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as detects two types of repeat patterns: repeated and cylindrical response patterning.\nConcepts: Coagulation in Device or Device Ingredient (Finding)\tConventional Therapy (Therapeutic or Preventive Procedure)\tnorepinephrine transport (catecholamine transport)\tchondrosarcoma; (Neoplasms)\tBASC-3 Response Pattern Index (Intellectual Product)", + "output": "BASC-3 Response Pattern Index (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of regulatory application.\nConcepts: Multiple gestation, NOS (Delivery AND/OR maternal condition affecting management)\tExtranodal (Spatial Concept)\tGood mood (Level of mood - finding)\tBox (Potency Unit)\tRegulatory Application Type Code (Type Code)", + "output": "Regulatory Application Type Code (Type Code)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the rheumatoid factor IgA antibody in a biological specimen.\nConcepts: acting out (Defense Mechanisms)\tREYNOLDS SYNDROME (Scleroderma and associated disorders)\tBreast Cancer Pathologic Primary Tumor TNM Finding v6 (Finding)\tRheumatoid Factor Antibody IgA Measurement (Laboratory Procedure)\tVaginal Diaphragm Dose Form (Biomedical or Dental Material)", + "output": "Rheumatoid Factor Antibody IgA Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as histone H2A type 1-A (131 aa, ~14 kDa) is encoded by the human H2AC1 gene. This protein is involved in chromatin remodeling.\nConcepts: MPAI1-Leisure and Recreation Activities (Intellectual Product)\tnephropathy IgA associated with liver disease (Chronic glomerulonephritis associated with another disorder)\tRenal CL for Dose Int Norm by WT (Renal Clearance for Dose Interval)\tinfectious meningitis (Meningitis)\tHIST1H2AA (Histone H2a)", + "output": "HIST1H2AA (Histone H2a)" + }, + { + "input": "Definition: failure of vertebral formation described as absence of one half of the vertebral body.\nConcepts: Web Portal, Patient (Intellectual Product)\tBilateral anophthalmos of eyes (Congenital Abnormality)\tFish Flavor (Food)\tHemivertebra (failure of vertebral formation)\t5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity (Molecular Function)", + "output": "Hemivertebra (failure of vertebral formation)" + }, + { + "input": "Definition: something described as any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell.\nConcepts: First metatarsals hypoplastic (Foot)\tHealthy People Programs (Health Care Activity)\tcellular manganese ion homeostasis (cellular transition metal ion homeostasis)\tBiliverdin Reductase A wt Allele (Gene or Genome)\tGlutathione S-Transferase Theta 1 wt Allele (GSTT1 gene)", + "output": "cellular manganese ion homeostasis (cellular transition metal ion homeostasis)" + }, + { + "input": "Definition: Dermatitis, Irritant described as an inflammatory skin condition caused by direct contact between the skin and an irritating substance. It is typically manifested by erythema, mild edema, and scaling at the affected site.\nConcepts: SOWS Subjective (Handelsman) - I'm Perspiring (Intellectual Product)\tMONITOR, LESION TEMPERATURE (Medical Device)\tdermatitis irritants (Korean Standard Classification of Disease Version 5)\tEncephalopathy, hypertrophic cardiomyopathy, renal tubular disease syndrome (Disease or Syndrome)\tdown-regulation of female gametophyte central cell differentiation (Cell Function)", + "output": "dermatitis irritants (Korean Standard Classification of Disease Version 5)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glycine + 2-oxoglutarate = glyoxylate + L-glutamate.\nConcepts: C-SSRS Baseline - Duration of Most Severe Ideation (Intellectual Product)\tglutamic-glyoxylic transaminase activity (aminotransferase activity)\tGRIP (Disorders, General, Functional and NEC)\tBilateral multiple fibroadenoma of breast (Disease or Syndrome)\tSteroid therapy for fetal lung maturation (Steroid therapy)", + "output": "glutamic-glyoxylic transaminase activity (aminotransferase activity)" + }, + { + "input": "Definition: Laboratory test related to hemostasis described as laboratory tests for evaluating the individual's blood clotting mechanisms.\nConcepts: Leishmaniasis, Diffuse Cutaneous (Disease due to Trypanosomatidae)\tBlood coagulation procedure (Laboratory)\tDriving Controls, Adaptive, Nonpowered (Medical Device)\toxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (Molecular Function)\tCalicivirus, NOS (Virus)", + "output": "Blood coagulation procedure (Laboratory)" + }, + { + "input": "Definition: Disorder of mitochondrial respiratory chain complexes described as a rare genetic mitochondrial oxidative phosphorylation disorder with characteristics of either late-onset myopathy with progressive external ophthalmoplegia and muscular weakness (predominantly limb-girdle) or early-onset myopathy presenting with decreased fetal movements, congenital ptosis, progressive external ophthalmoplegia, hypotonia and variably joint contractures. Reduced content and multiple deletions of mitochondrial DNA is observed in muscle biopsy. Caused by heterozygous mutation in the DNA2 gene on chromosome 10q.\nConcepts: GOSE1-Since Injury Any Epileptic Fits (Intellectual Product)\tMitochondrial DNA deletion syndrome with progressive myopathy (Hereditary disorder of musculoskeletal system)\tenvironment: special hospital (Hospital environment)\tDental Materials, Disinfection, Endodontic (Medical Device)\tMetaphyseal Dysplasia, Braun-Tinschert Type (Dysplasia with increased bone density)", + "output": "Mitochondrial DNA deletion syndrome with progressive myopathy (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: Head and Neck Cancer Pathologic TNM Finding v8 described as a pathologic finding about one or more characteristics of cutaneous squamous cell carcinoma of the head and neck, following the rules of the TNM AJCC v8 classification system.\nConcepts: HER1 (Laboratory Procedure)\tVaginal Rhabdomyoma (Benign neoplasm vagina)\tEdisylate, Prochlorperazine (Pharmacologic Substance)\tCutaneous Squamous Cell Carcinoma of the Head and Neck Pathologic TNM Finding v8 (Head and Neck Cancer Pathologic TNM Finding v8)\t4-(4-aminophenylsulfonyl)benzenamine (Organic Chemical)", + "output": "Cutaneous Squamous Cell Carcinoma of the Head and Neck Pathologic TNM Finding v8 (Head and Neck Cancer Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Organic Chemical described as highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic, it may also may reduce triglyceride levels.\nConcepts: 10^3 copies/mL (Quantitative Concept)\tBacterial Esophagitis (Infective esophagitis)\tradionuclide therapy (radiation therapy modality)\tColestipol (Nitrogen and nitrogen compound)\tAmidation/Deamidation (chemical reaction)", + "output": "Colestipol (Nitrogen and nitrogen compound)" + }, + { + "input": "Definition: Qualitative Concept described as a data type comprised of a collection of a discrete set of entity names.\nConcepts: DSET (Qualitative Concept)\tCULTURE MEDIA, ANTIMICROBIAL SUSCEPTIBILITY TEST (Medical Device)\tVFQ1-Main Reason You Gave Up Driving (VFQ25-Interviewer Administered Format Questionnaire Question)\tNon-IP Docn Shipmt (Intellectual Product)\tSomatic nerve (General anatomical term)", + "output": "DSET (Qualitative Concept)" + }, + { + "input": "Definition: Cell Count described as the determination of the ratio of blasts compared to nucleated cells present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Mental Status and Dementia Tests (Intellectual Product)\tCOLORIMETRIC, MUCOPOLYSACCHARIDES (Medical Device)\tp300/CBP-ASSOCIATED FACTOR (Transferase Gene)\tBlasts/Nucleated Cells (Laboratory Procedure)\tCongenitally corrected transposition of the great arteries with ventricular septal defect (Congenitally Corrected Transposition of the Great Arteries)", + "output": "Blasts/Nucleated Cells (Laboratory Procedure)" + }, + { + "input": "Definition: Synaptic Membranes described as synaptic membrane, each instance of which is an areaof plasma membrane of some presynaptic axon within some synapse and has sites for release of some neurotransmitters.\nConcepts: Presynaptic membrane (Cell Component)\torganic solvent (Miscellaneous Drugs)\tup-regulation of convergent extension involved in notochord morphogenesis (regulation of convergent extension involved in notochord morphogenesis)\tViscosity (fluid property)\tNaranjo Checklist (Intellectual Product)", + "output": "Presynaptic membrane (Cell Component)" + }, + { + "input": "Definition: Ampulla of Vater Cancer Pathologic Primary Tumor TNM Finding v7 described as ampulla of Vater cancer in which the primary tumor cannot be assessed.\nConcepts: Surgeries, Metabolic (Operative Surgical Procedures)\tAmpulla of Vater Cancer pTX TNM Finding v7 (Ampulla of Vater Cancer Pathologic Primary Tumor TNM Finding v7)\tPerformedExclusionCriterion (Qualitative Concept)\tadipocytokine signaling pathway (Signal Transduction Pathways)\tPleural drainage system (biomedical tube device)", + "output": "Ampulla of Vater Cancer pTX TNM Finding v7 (Ampulla of Vater Cancer Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Structure of artery of pelvic cross-sectional segment of trunk described as either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.\nConcepts: Iliac Arteries (Structure of aorta-iliac artery junction)\tBenzene, hexachloro- (chlorobenzene)\tLY2510924 (Pharmacologic Substance)\tphospholipid hydroperoxide glutathione peroxidase activity (oxidoreductase activity, acting on peroxide as acceptor)\tFlap Endonuclease 1 (Enzyme)", + "output": "Iliac Arteries (Structure of aorta-iliac artery junction)" + }, + { + "input": "Definition: Skin described as the area of skin being supplied by specific peripheral nerves and localized synaptic distribution in the CNS.\nConcepts: dermatome (Neuroanatomy)\tMembrane of the Brain or Spinal Cord (Body Part, Organ, or Organ Component)\tmitral valves (Cardiovascular system)\tneratinib (Organic Chemical)\tPhosphoinositol Kinase Family Gene (Kinase Family Gene)", + "output": "dermatome (Neuroanatomy)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation.\nConcepts: Periumbilical part of abdomen (Body Regions)\tSMC/kleisin ring complex location (protein-containing complex)\tWD7-Getting Work Done Quickly as Needed (Intellectual Product)\themopoietic stem cell differentiation (Cell Function)\tresponse to pheromone regulating pheromone-induced unidirectional conjugation (Cell Function)", + "output": "response to pheromone regulating pheromone-induced unidirectional conjugation (Cell Function)" + }, + { + "input": "Definition: something described as serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (512 aa, ~58 kDa) is encoded by the human PPP3CC gene. This protein is involved in protein dephosphorylation, calmodulin binding, and apoptotic signaling.\nConcepts: Health Service, Student (Health Care Activity)\tImmunoglobulin G4, Anti-(Human Receptor 4-1BB) (Human Gamma-Chain), Disulfide with Human Kappa-Chain, Dimer (Pharmacologic Substance)\tNTNRA (Gene or Genome)\tphoton (Electromagnetic Radiation)\tCAM-PRP Catalytic Subunit (Amino Acid, Peptide, or Protein)", + "output": "CAM-PRP Catalytic Subunit (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Sign or Symptom described as ataxia associated with chaotic multidirectional conjugate eye movements secondary to metastatic tumors to cerebellum. The most common malignant tumor associated with this paraneoplastic syndrome is lung carcinoma.\nConcepts: Paraneoplastic Opsoclonus-Ataxia (Sign or Symptom)\tNCI CTEP SDC Hematopoietic Neoplasm/Leukemia Category Terminology (NCI CTEP Simplified Disease Classification Terminology)\tCRQ01-Feel Upset, Worried or Depressed (Intellectual Product)\tChildhood Gastrointestinal Stromal Tumor (Pediatric Neoplasm)\t3-oxosphinganine:NADPH oxidoreductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)", + "output": "Paraneoplastic Opsoclonus-Ataxia (Sign or Symptom)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism.\nConcepts: toxin metabolic process (Molecular Function)\t7 beta, 17 alpha-dimethyltestosterone (Androgens)\tNasal Cavity and Paranasal Sinuses Cancer pN2a TNM Finding v8 (Finding)\tListeria innocua (Listeria)\tU5 snRNA 3'-end processing (snRNA 3'-end processing)", + "output": "toxin metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as the measurement a pulse wave's amplitude by palpation.\nConcepts: cellular response to red or far red light (cellular response to light stimulus)\tLEC01-Captivity: Job (Intellectual Product)\tDeficiency Disease, Argininosuccinic Acid Synthase (Disease or Syndrome)\tPlatelet Derived Growth Factor Isoform AA Measurement (Protein or Enzyme Type Measurement)\tPulse Wave Amplitude Measurement (ACC-AHA Measure)", + "output": "Pulse Wave Amplitude Measurement (ACC-AHA Measure)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder of the white matter of the brain causing neurological problems, which can occur, anytime from childhood to adulthood. Characteristics of the disease include learning disabilities, retinopathy, atrophy of the optic nerves, spasticity, infertility in males, vertigo, tinnitus, hearing loss, paroxysmal kinesigenic dyskinesia and psychiatric disorders. In affected individuals, myelin becomes edematous causing impaired nerve impulse transmission. Caused by mutations in the CLCN2 gene. Inherited in an autosomal recessive pattern.\nConcepts: L-dopa transaminase activity (aminotransferase activity)\tLEUKOENCEPHALOPATHY WITH ATAXIA (Leukoencephalopathy)\tDiseases, Iatrogenic (Pathologic Processes)\tCREB3L2-PPARgamma Fusion Gene (Fusion Gene)\tFunctional Assessment of Cancer Therapy-Leukemia Version 4 Questionnaire Test Name (CDISC Questionnaire Terminology)", + "output": "LEUKOENCEPHALOPATHY WITH ATAXIA (Leukoencephalopathy)" + }, + { + "input": "Definition: Iodinated contrast media described as a diagnostic aid as a radiopaque medium in cholecystography.\nConcepts: IVD Test Reagent/Kits, Clinical Chemistry, Lipid, Lecithin/Sphingomyelin Ratio (IVD Test Reagent/Kits, Clinical Chemistry, Lipid)\tClostridium symbiosum (Stevens 1956) Kaneuchi et al. 1976 (Clostridium species q-z)\ttyropanoate (Iodobenzenes)\tHemic and Lymphatic Diseases (Italian translation of Medical Subject Headings)\tdownregulation of sulfur utilization (regulation of sulfur utilization)", + "output": "tyropanoate (Iodobenzenes)" + }, + { + "input": "Definition: Planned Study Subject Experience described as a description of what the study subject can expect to experience over the course of the study, including the sequence and duration of activities.\nConcepts: Study Protocol Version Planned Study Subject Experience (Qualitative Concept)\tTorulopsis, NOS (Saccharomycetales)\tgamma-delta T-cell lineage commitment (T cell lineage commitment)\twater safety (Knowledge level: personal safety)\tcell growth involved in Malpighian tubule morphogenesis (Cell Function)", + "output": "Study Protocol Version Planned Study Subject Experience (Qualitative Concept)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the tyrosine hydroxylase (TH) gene, located at chromosome 11p15.5, which encodes the protein tyrosine 3-monooxygenase. Genetic variants at this locus have been associated with Segawa syndrome.\nConcepts: abdominal brace@@MISCELL@EACH (Medical Device)\tRibonuclease P/MRP 40kDa Subunit wt Allele (RPP40 gene)\tcytoplasmic vesicle lumen (vesicle lumen)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TH (Medical Device)\tcolesevelam hydrochloride (Organic Chemical)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TH (Medical Device)" + }, + { + "input": "Definition: something described as a change in the amino acid residue at position 12 in the GTPase KRas protein where glycine has been replaced by valine.\nConcepts: c-K-ras G12V (KRAS NP 004976.2:p.G12X)\tH3C6 (Gene or Genome)\tHow Much Time Spent at Hospital for Appointments (Intellectual Product)\tMFIS0121 (Intellectual Product)\tBiology, Synthetic (biology)", + "output": "c-K-ras G12V (KRAS NP 004976.2:p.G12X)" + }, + { + "input": "Definition: Benzoates described as mercury-containing benzoic acid derivatives.\nConcepts: Benign Extrahepatic Bile Duct Non-Epithelial Neoplasm (Benign neoplasm of extrahepatic bile ducts)\tMercuribenzoates (Benzoates)\tPerformedObservationResult.valueNullFlavorReason (Value Null Flavor Reason)\tmitotic spindle pole body (Cell Component)\tstage IIIB bladder carcinoma AJCC v8 (Stage III Bladder Cancer AJCC v6 and v7)", + "output": "Mercuribenzoates (Benzoates)" + }, + { + "input": "Definition: something described as a subdivision of the occipital lobe of the macaque and the guenon; it is defined on the basis of myeloarchitecture. Mauss regarded it as topologically homologous to the cytoarchitectonic area 18 of Brodmann (guenon) ( Mauss-1908 ).\nConcepts: SCF-YDR131C ubiquitin ligase complex (SCF ubiquitin ligase complex)\tMauss's area 18 (Body Location or Region)\tACD (Disease or Syndrome)\tT1a Stage (Tumor stage T1)\tSerratia glossinae (Bacterium)", + "output": "Mauss's area 18 (Body Location or Region)" + }, + { + "input": "Definition: Calcium-Binding Proteins described as calcium and integrin-binding protein 1 (191 aa, ~22 kDa) is encoded by the human CIB1 gene. This protein plays a role in calcium binding, integrin activity regulation, apoptosis modulation and megakaryocyte differentiation.\nConcepts: KIP protein, human (Biologically Active Substance)\tBPRSA1-Tension (Intellectual Product)\taldonic acid metabolism (Molecular Function)\tReceptor Down Regulation (Receptor Desensitization)\tHemlock (Apiaceae)", + "output": "KIP protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Disease or Syndrome described as rapidly destructive shoulder joint and bone disease found mainly in elderly, and predominantly in women. It is characterized by SHOULDER PAIN; JOINT INSTABILITY; and the presence of crystalline CALCIUM PHOSPHATES in the SYNOVIAL FLUID. It is associated with ROTATOR CUFF INJURIES.\nConcepts: Muscularis mucosae (Digestive tract part)\tTotal Body Clearance by Fraction of Dose for Dose Interval (Quantitative Concept)\t3 (Former smoker)\ttopical fluoride (Biomedical or Dental Material)\tMilwaukee shoulder (Calcium pyrophosphate deposition disease)", + "output": "Milwaukee shoulder (Calcium pyrophosphate deposition disease)" + }, + { + "input": "Definition: positive regulation of DNA repair described as any process that activates or increases the frequency, rate or extent of mismatch repair.\nConcepts: positive regulation of mismatch repair (regulation of mismatch repair)\tInsp(6) kinase 2 protein, human (Enzyme)\tBlood Island (Other Embryologic Structure)\tTransthyretin Amyloid Cardiomyopathy (Cardiomyopathies)\tspecification of symmetry (Organ or Tissue Function)", + "output": "positive regulation of mismatch repair (regulation of mismatch repair)" + }, + { + "input": "Definition: Polyamines described as an iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.\nConcepts: dtpa (Polyamines)\tlumenal side of plastid thylakoid membrane (side of membrane)\tBluetick Coonhound (Hound)\tSTAT3 Decoy ODN (Antisense Oligonucleotides)\tLow Grade Intraepithelial Neoplasia (Intraepithelial Neoplasia)", + "output": "dtpa (Polyamines)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell in the larval wing imaginal disc becomes capable of differentiating autonomously into a notum cell, if left in its normal environment.\nConcepts: notum cell fate specification (cell fate specification involved in pattern specification)\tReason For Procedure (Indication of)\tphosphinothricin, monoammonium salt (Pesticides)\tAortic Valve Prolapses (Aortic valve disorder)\tCurrent Medication (Finding)", + "output": "notum cell fate specification (cell fate specification involved in pattern specification)" + }, + { + "input": "Definition: Artery of lower extremity described as an artery arising from the common femoral artery just below the inguinal ligament running close to the femur and ending in the lower third of the thigh with branches supplying the thigh muscles.\nConcepts: Teething Syndrome (Diseases of oral cavity and salivary glands)\tOrgan system subdivision (Body System)\tvaginal neoplasm (Vulvovaginal cysts and neoplasms)\tSphingomonadaceae Kosako et al. 2000 (Sphingomonadales)\tStructure of profunda femoris artery (Femoral and/or popliteal artery structures)", + "output": "Structure of profunda femoris artery (Femoral and/or popliteal artery structures)" + }, + { + "input": "Definition: penis described as the cone or head of the penis.\nConcepts: Univariate Normal Distribution (Normal Statistical Distribution)\tFetal ultrasound soft marker (Finding)\tEpisodic upper airway obstruction (Finding)\tPeni, Glans (penis)\tDiverticulosis, Gastric (Diverticulitis)", + "output": "Peni, Glans (penis)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had hair loss.\nConcepts: Microtubule Organizing Center (Cell Component)\tPeripheral blood (Body Fluids)\tHave you lost any hair (Clinical or Research Assessment Question)\tHEPARIN ANTAG (Coagulants)\tganglia structural organization (Morphogenesis)", + "output": "Have you lost any hair (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Blood Cell Count Ratio Measurement described as a relative measurement (ratio or percentage) of the blasts to leukocytes in a biological specimen.\nConcepts: Pain or paresthesias, median nerve distribution (Wrist(s) and/or Hand(s))\tcalcium ion sensor activity (small molecule sensor activity)\tBlasts/Leukocytes (Laboratory Procedure)\tregulation of anterior-posterior axon guidance (regulation of axon guidance)\tCACT DEFICIENCY (Lipid Metabolism, Inborn Errors)", + "output": "Blasts/Leukocytes (Laboratory Procedure)" + }, + { + "input": "Definition: something described as any process that modulates the rate, frequency, or extent of directed movement of a motile cell or organism up a concentration gradient of 3',5'-cAMP by the action of DIF-2. DIF-2 is a chlorinated alkylphenone.\nConcepts: regulation of positive chemotaxis to cAMP by DIF-2 (regulation of positive chemotaxis to cAMP by chlorinated alkylphenone)\tMitochondrial Anemia Gene Deletion/Duplication Panel Reagents (Medical Device)\tretinoic acid receptor signalling pathway involved in lung bud formation (retinoic acid receptor signaling pathway)\tGrade 2 Muscle cramp (Muscle Cramp, CTCAE)\tlymph vessel formation (Physiologic Function)", + "output": "regulation of positive chemotaxis to cAMP by DIF-2 (regulation of positive chemotaxis to cAMP by chlorinated alkylphenone)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's distress from their difficulty concentrating.\nConcepts: lun8 ajstmnt ea.ajstmnt (Therapeutic or Preventive Procedure)\tincreased platelets (Hematological Disease)\tDifficulty concentrating (Intellectual Product)\tavelumab (Monoclonal antibodies, antineoplastic)\tA10 dopamine cells (dopaminergic cell groups)", + "output": "Difficulty concentrating (Intellectual Product)" + }, + { + "input": "Definition: Bunyaviridae described as any viral organism that can be assigned to the genus Phlebovirus.\nConcepts: PANSS - Suspiciousness or Persecution (PANSS Clinical Classification Question)\tPhlebotomus fever virus (Phenuiviridae)\tLymph nodes--Diseases (Disease or Syndrome)\tLarge cell lung cancer recurrent (Non-small cell neoplasms malignant of the respiratory tract cell type specified)\tdescending branches of the dorsal root fibers (Dorsal funiculus)", + "output": "Phlebotomus fever virus (Phenuiviridae)" + }, + { + "input": "Definition: MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a role in the development of carcinoma of the breast.\nConcepts: Metatarsal Bone Digit 1 (Metatarsal bone structure)\tMDASI Symptom Interference with Life Score 6 (Clinical or Research Assessment Answer)\tFLJ14040 (Gene or Genome)\tMIRN516A2 (Gene or Genome)\tOperculum frontoparietale (Body Part, Organ, or Organ Component)", + "output": "MIRN516A2 (Gene or Genome)" + }, + { + "input": "Definition: Temporal observable described as a date on which an event or observation was reported.\nConcepts: Date of Report (Temporal observable)\turinary tract smooth muscle contraction (smooth muscle contraction)\tcell adhesion (cellular process)\tAspirators, Endocervical (Obstetrical/gynecological device)\tGH Receptor (Amino Acid, Peptide, or Protein)", + "output": "Date of Report (Temporal observable)" + }, + { + "input": "Definition: Other symptoms involving skin and integumentary tissues described as a widespread, acute rash.\nConcepts: WPPSI-IV Picture Memory (Research or Clinical Assessment Tool)\tSKIN ERUPTION (Eruptions)\tGrade 4 Neonatal Sinus Tachycardia, Adverse Event (Finding)\tFamily Violence (Antisocial Behavior & Behavior Disorders)\tFiberoptic (Device Component or Accessory)", + "output": "SKIN ERUPTION (Eruptions)" + }, + { + "input": "Definition: RouteBySite described as a route that begins within the abdomen.\nConcepts: Retinoblastoma pM1b TNM Finding v7 (Retinoblastoma Pathologic Distant Metastasis TNM Finding v7)\tFiltration, Moving Filter (filtration)\tINTRA-ABDOMINAL (Parenteral Route of Drug Administration)\tSystem Dynamics Analysis (Information Sciences)\tpsych tstng ea.15min (Health Care Activity)", + "output": "INTRA-ABDOMINAL (Parenteral Route of Drug Administration)" + }, + { + "input": "Definition: Research Design described as the detailed planning of a study of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects.\nConcepts: Struggle with Rent or Mortgage Due to Financial Difficulties (Intellectual Product)\tSmall Integral Membrane Protein 5, Human (Regulatory Protein)\tMGC9294 (Gene or Genome)\tClock Speed (Quantitative Concept)\tTrial Design (Research Design)", + "output": "Trial Design (Research Design)" + }, + { + "input": "Definition: Criterion Validity described as a performance outcome measure that assesses the degree to which the scores of a clinical outcome assessment instrument are related to a known gold standard measure of the same concept.\nConcepts: Peyer's patches (Lymphatic follicle)\tSubcutaneous use (Parenteral)\tAbnormal globus pallidus morphology (Anatomical Abnormality)\tClinical Outcome Assessment Criterion Validation (Quantitative Concept)\tPostoperative Infection (Perioperative/Postoperative Complications)", + "output": "Clinical Outcome Assessment Criterion Validation (Quantitative Concept)" + }, + { + "input": "Definition: Benign Neoplasm described as a non-metastasizing neoplasm arising from the lung parenchyma, bronchial tree, or trachea. Representative examples include lung hamartoma, lung papilloma, and tracheal leiomyoma.\nConcepts: Benign Tumor of the Respiratory Tract (Neoplasm of lower respiratory tract)\tANSD0104 (Intellectual Product)\tGrade 4 Colonic Hemorrhage, CTCAE (Colonic Hemorrhage, CTCAE 5)\tTonsillar Undifferentiated Carcinoma (Neoplastic Process)\tCSC-21K (Biologically Active Substance)", + "output": "Benign Tumor of the Respiratory Tract (Neoplasm of lower respiratory tract)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify deletions or duplications of the mitochondrial thymidine kinase 2 (TK2) gene, located at chromosome 16q21, which encodes the mitochondrial protein thymidine kinase 2. Genetic variants at this locus have been associated with mitochondrial DNA depletion syndrome.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TK2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tKetoconazolum (Antibiotics, Antifungal)\tCORONARY SINUS (Heart part)\tterpenoid biosynthetic process, mevalonate-independent (Molecular Function)\tIntracerebral (Spatial Concept)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, TK2 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Disorder of endocrine pancreas described as a rare, inherited disorder that affects the endocrine glands and can cause tumors in the parathyroid and pituitary glands and the pancreas. These tumors are usually benign (not cancer). They cause the glands to secrete high levels of hormones, which can lead to other medical problems, such as kidney stones, fertility problems, and severe ulcers. In some cases, tumors inside the pancreas can become malignant (cancer).\nConcepts: Oxysterols Receptor LXR-Alpha (Receptor)\tinsufficiency; vascular, peripheral (Disease or Syndrome)\tNEOPL MULTIPLE ENDOCRINE TYPE 1 (Neoplasm of uncertain behavior of pancreas)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Mycobacterium tuberculosis (Medical Device)\tIngredients, Food (Food)", + "output": "NEOPL MULTIPLE ENDOCRINE TYPE 1 (Neoplasm of uncertain behavior of pancreas)" + }, + { + "input": "Definition: Disease or Syndrome described as varicella zoster virus that is transmitted via respiratory secretions and vesicular skin lesions; clinical manifestations are fever and pruritic, vesicular skin rash ten to twenty-one days after exposure. Clinical complications (e.g., lung, liver and CNS) can occur, especially in immunocompromised individuals.\nConcepts: 5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethane sulfonate 2-methyltransferase complex (Cell Component)\tSurfactant Polypeptide SP-C (Membrane Proteins)\tChickenpox - varicella (Unspecified viral infection characterized by skin and mucous membrane lesions)\tAcid Hybridizations, Nucleic (Biochemical Phenomena)\tAVL01-List A Recall 2 Word 5 (ADNI-AVLT Questionnaire Question)", + "output": "Chickenpox - varicella (Unspecified viral infection characterized by skin and mucous membrane lesions)" + }, + { + "input": "Definition: something described as laboratory findings and bleeding\nConcepts: FLUOXYMESTERONE (Organic Chemical)\tbiotransformation drug (Metabolic Process, Cellular)\tGrade 3 Disseminated Intravascular Coagulation, CTCAE (Finding)\t14.7K-INTERACTING PROTEIN (Gene or Genome)\tMKK3 Protein Kinase (Enzyme)", + "output": "Grade 3 Disseminated Intravascular Coagulation, CTCAE (Finding)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 17p\nConcepts: L-glutamine(L-asparagine) amidohydrolase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tData Compilation and Analysis Shared Resource (Clinical or Research Facility)\tregulation of host catalytic activity by symbiont (Organism Function)\t17p12-p11.2 (Cell Component)\tRecurrent Ovarian Mucinous Adenocarcinoma (Recurrent Ovarian Adenocarcinoma)", + "output": "17p12-p11.2 (Cell Component)" + }, + { + "input": "Definition: Neonatal Respiratory Insufficiency, Adverse Event described as clinical evidence of increased respiratory distress with relevant deterioration in gas exchange (increase in pCO2 or decrease in oxygenation); requiring major care change (e.g. start invasive support).\nConcepts: Metastatic Hypopharyngeal Carcinoma (Metastatic Pharyngeal Carcinoma)\tCSS09-First Attempt Damage (Intellectual Product)\tPhosphorus-oxygen lyase -RETIRED- (Amino Acid, Peptide, or Protein)\tPituitary gonadotropin deficiency (Endocrine abnormalities of gonadal function NEC)\tGrade 3 Neonatal Respiratory Insufficiency (Neonatal Respiratory Insufficiency, Adverse Event)", + "output": "Grade 3 Neonatal Respiratory Insufficiency (Neonatal Respiratory Insufficiency, Adverse Event)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Children (TSCC) Feeling like nobody likes me.\nConcepts: geranyldiphosphate diphosphate lyase [(+)-(R)-limonene-forming] activity (Molecular Function)\tTSCC - Feeling Like Nobody Likes Me (TSCC Questionnaire Question)\tSponge Detectors, Surgical (Medical Device)\tSCB-01A (Pharmacologic Substance)\tFrontal lobe structure (Entire cerebral lobe)", + "output": "TSCC - Feeling Like Nobody Likes Me (TSCC Questionnaire Question)" + }, + { + "input": "Definition: Enzyme described as a disintegrin and metalloproteinase with thrombospondin motifs 13 (1427 aa, ~154 kDa) is encoded by the human ADAMTS13 gene. This protein plays a role in the proteolysis of von Willebrand factor multimers.\nConcepts: KVLQT1 Protein (Amino Acid, Peptide, or Protein)\tvWF-CP (Metalloproteases)\tInjection Dosing Unit (Quantitative Concept)\tRetinoblastoma cT4a TNM Finding v7 (Retinoblastoma cT4 TNM Finding v7)\tProtocol Risk Assessment (Health Care Activity)", + "output": "vWF-CP (Metalloproteases)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Leminorella grimontii.\nConcepts: CDC Enteric group 57 (Genus Leminorella)\tregulation of unsaturated fatty acid biosynthesis (Cell Function)\tASSAY, GLUTATHIONE REDUCTASE (Indicator, Reagent, or Diagnostic Aid)\tPhosphatidylinositol-4-Phosphate 3-Kinase, Catalytic Subunit Type 2 Gamma wt Allele (PIK3C2G gene)\tOvarian neoplasms, malignant and unspecified (Classification)", + "output": "CDC Enteric group 57 (Genus Leminorella)" + }, + { + "input": "Definition: something described as lights designed to provide illumination to the surgical site that are mounted on fixtures (e.g., lamps) fixed to the ceiling. These units typically have counterbalanced arms that are free to rotate continuously at every joint to satisfy various needed height and angles during surgery. These lights offer a good illumination over a prolonged period of time on a flat and narrow surface and/or in a deep surgical cavity to assist medical personnel during a surgical procedure. They provide high-intensity illumination while reducing shadows and producing minimal color distortion. Ceiling-mounted surgical lights are available in several shapes and sizes and use various types of bulbs such as incandescent, compact fluorescent lamp (CFL), halogen, and light-emitting diodes (LED). Single-head as well as multiple-head ceiling-mounted lights are also available.\nConcepts: swelling of the retina (Retinitis)\tThyrotropin Receptor, human (G-Protein-Coupled Receptors)\tLIGHT, SURGICAL, CEILING MOUNTED (Lights, Surgical)\tELECTRODE, FLEXIBLE SUCTION COAGULATOR, REPROCESSED (Medical Device)\tRefractory Hodgkin's Disease Lymphocyte Predominance Type (Lymphocyte Predominant Type Hodgkin's Disease)", + "output": "LIGHT, SURGICAL, CEILING MOUNTED (Lights, Surgical)" + }, + { + "input": "Definition: Congenital Abnormality described as congenital absence of the normal opening of a structure of the urinary tract.\nConcepts: Dwarf, mesomelic (Chronic disease of musculoskeletal system)\tInjury to liver with open wound into cavity (Internal injury of abdominal organs with open wound into cavity)\tUrinary tract atresia (Congenital Abnormality)\tMFIS01-Have Difficulty Paying Attention (Intellectual Product)\tTricuspid Valve Regurgitant Fraction (Cardiovascular finding)", + "output": "Urinary tract atresia (Congenital Abnormality)" + }, + { + "input": "Definition: Expanded DRS-PI Survivor Version Questionnaire Question described as expanded Disability Rating Scale - Postacute Interview Survivor Version - Do you require assistance from another person to manage emotions and behavior?\nConcepts: Perihilar Bile Duct Cancer Clinical Distant Metastasis TNM Finding v7 (Perihilar Bile Duct Cancer Clinical TNM Finding v7)\tPositive Integer (Cardinal number)\tExpanded DRS-PI Survivor Version - Require Assistance Managing Emotions (Intellectual Product)\tKOS (Language)\tNone (Clinical or Research Assessment Answer)", + "output": "Expanded DRS-PI Survivor Version - Require Assistance Managing Emotions (Intellectual Product)" + }, + { + "input": "Definition: post-embryonic animal morphogenesis described as the process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized.\nConcepts: wing vein morphogenesis (post-embryonic animal morphogenesis)\tAlveolar adenoma (Adenoma AND/OR adenocarcinoma)\tGlyceryl triacetate (T [Preparations])\tNAB2-STAT6 Fusion Protein (Amino Acid, Peptide, or Protein)\t1,2-dihydrosantonin:NAD(P)+ 1,2-oxidoreductase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)", + "output": "wing vein morphogenesis (post-embryonic animal morphogenesis)" + }, + { + "input": "Definition: Small cell carcinoma of lung described as cancer is found in one lung, the tissues between the lungs, and nearby lymph nodes only.\nConcepts: 2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (Molecular Function)\tSmith Extractable Nuclear Antibody (Immunologic Tests)\tlung cancer, limited stage small cell (Small cell carcinoma of lung)\tIVD Test Reagent/Kits, Clinical Chemistry, Trace Metal, Iron, Total Binding Capacity (IVD Test Reagent/Kits, Clinical Chemistry, Trace Metal, Iron)\tdriving phobia (Mental or Behavioral Dysfunction)", + "output": "lung cancer, limited stage small cell (Small cell carcinoma of lung)" + }, + { + "input": "Definition: something described as a coded value specifying the kind of package.\nConcepts: Oxirane (Disinfectants and cleansers)\tethinyl estradiol and norethindrone (Progestogens and estrogens systemic contraceptives, sequential preparations)\tLMO1 protein, human (Amino Acid, Peptide, or Protein)\tclaudin 4 (Amino Acid, Peptide, or Protein)\tPackage.typeCode (Intellectual Product)", + "output": "Package.typeCode (Intellectual Product)" + }, + { + "input": "Definition: Sign or Symptom described as time marking early onset of disease\nConcepts: megakaryocyte development (Cell Function)\tPolysaccharide Hydrolase (Enzyme)\tProdromal Period (Sign or Symptom)\tsmokings (inhalation, smoking, sniffing)\tEctonucleoside Triphosphate Diphosphohydrolase 1 wt Allele (Gene or Genome)", + "output": "Prodromal Period (Sign or Symptom)" + }, + { + "input": "Definition: Plant described as a plant genus of the family RHAMNACEAE. This genus is often called buckthorn but should not be confused with HIPPOPHAE or KARWINSKIA. Some RHAMNUS species have been reclassified into this genus. F. purshiana bark is cascara sagrada. Members contain frangulanin, frangulin, and anthraquinones such as EMODIN.\nConcepts: R3/R4 cell differentiation (Organ or Tissue Function)\tMental Impression (Mental Processes)\tExponent (Numbers)\tBuckthorn (Rhamnaceae)\tpositive regulation of viral entry into host cell (Biologic Function)", + "output": "Buckthorn (Rhamnaceae)" + }, + { + "input": "Definition: Antigen Gene described as this gene plays a role in the immune response.\nConcepts: Less than 25% (Finding)\tFAC057-Satisfied With How I Am Coping (Intellectual Product)\tMSPS (Gene or Genome)\tLower Opening of the Thorax (Body Space or Junction)\tG antigen, family D, 3 (Antigen Gene)", + "output": "G antigen, family D, 3 (Antigen Gene)" + }, + { + "input": "Definition: CDISC Protocol Terminology described as terminology associated with the study type codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Cola (Plant)\tFUSARIUM CHLAMYDOSPORUM (Fusarium chlamydosporum species complex)\thistone H4 deacetylation (Molecular Function)\tSDTM-STYPE (CDISC Protocol Terminology)\tBTB Domain Containing 18 wt Allele (Gene or Genome)", + "output": "SDTM-STYPE (CDISC Protocol Terminology)" + }, + { + "input": "Definition: PODCI Adolescent Parent-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported - During the last week, has it been easy or hard for your child to: Climb one flight of stairs?\nConcepts: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling (gap junction channel activity involved in cardiac conduction electrical coupling)\tpapilloma (Neoplasms benign site unspecified NEC)\tPODCI221 (Intellectual Product)\tMGC14399 (Gene or Genome)\tMesorhizobium (Bacterium)", + "output": "PODCI221 (Intellectual Product)" + }, + { + "input": "Definition: something described as transducers designed to convert electrical signals into mechanical energy in the form of sound (i.e., ultrasonic signals) and vice versa. These devices typically consist of an active element (e.g., ceramic or piezoelectric polymer) as well as a high-attenuation, high-density material that is used to control the vibration of the transducer by absorbing the energy radiating from the back face of the active element (i.e., a backing element); some transducers also include a wear plate that protects the transducer element from the environment. Features available for ultrasonic transducers include array configuration for connecting more than one transducer in series or in parallel. Ultrasonic transducers are typically housed in an enclosure (i.e., an ultrasonic probe) that is attached through an integral cable to ultrasound medical equipment (e.g., echocardiographs, ultrasonic scanners); ultrasonic transducers used with therapeutic devices (e.g., lithotripters) only transduce electric signals into ultrasound waves.\nConcepts: Fleming Method (Therapeutic or Preventive Procedure)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Genital Bacteria (Medical Device)\tTransducers, Ultrasonic (Medical Device)\tintracellular mRNA localization involved in pattern specification process (Genetic Function)\tAmoxapine-containing product (Tricyclic Antidepressive Agents)", + "output": "Transducers, Ultrasonic (Medical Device)" + }, + { + "input": "Definition: Vascular therapeutic procedures NEC described as the blocking of an artery by a clot or foreign material. Embolization can be done as treatment to block the flow of blood to a tumor.\nConcepts: mntl hlth mgmt (Mental health care)\tGiant pigmented nevus (Nevus AND/OR melanoma)\ttranscytosis (Cell Function)\tTurnover, Mitochondrial (Cell physiology)\tEmbolization, Therapeutic (Clinical actions A - G)", + "output": "Embolization, Therapeutic (Clinical actions A - G)" + }, + { + "input": "Definition: Occupational Activity described as planning and design of environment with goals of efficient human-environment interaction and minimal ecological disruption.\nConcepts: nucleobase-containing compound transmembrane transporter activity (Molecular Function)\tDKFZp434J0911 (ADGRA2 gene)\tLinoleyl Carbonate-paclitaxel (Pharmacologic Substance)\tPlectrovirus (Inoviridae)\tEnvironmental Planning (Occupational Activity)", + "output": "Environmental Planning (Occupational Activity)" + }, + { + "input": "Definition: Ion Channel Protein described as a protein found in cell membranes that moves calcium into cells. Levels of transient receptor potential cation channel, subfamily V, member 6 are lower than normal in patients who don't have enough vitamin D. High levels of the protein may be found in breast cancer tissue. It is a type of calcium channel protein.\nConcepts: TOM complex location (Cell Component)\tBETA-GLOBULIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tInduced Expectoration Technique (diagnostic procedure)\tcilium disassembly (cilium organization)\ttransient receptor potential cation channel, subfamily V, member 6 (Biologically Active Substance)", + "output": "transient receptor potential cation channel, subfamily V, member 6 (Biologically Active Substance)" + }, + { + "input": "Definition: PSA Level Finding described as a blood concentration of prostate specific antigen greater than or equal to 50 ng/mL.\nConcepts: PSA Level Greater than or Equal to Fifty (PSA Level Finding)\tProfessional Burnout (Occupational Stress)\tF420H2:NADP+ oxidoreductase activity (Molecular Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, ATXN1 Gene (Medical Device)\t3,4-Catechol Estrogen Specific (Amino Acid, Peptide, or Protein)", + "output": "PSA Level Greater than or Equal to Fifty (PSA Level Finding)" + }, + { + "input": "Definition: Finding described as melanoma of the palpebral, forniceal, or caruncular conjunctiva with tumor measuring more than 0.5 mm but not more than 1.5 mm in thickness with invasion of the substantia propria.\nConcepts: Melanoma of the Conjunctiva pT2b TNM Finding v7 (Melanoma of the Conjunctiva Pathologic Primary Tumor TNM Finding v7)\tkeratectomy (Excision)\tlobule II (Central lobule of cerebellum)\tMorphologic Complete Response (Disease Response)\tRNF216 protein, human (ubiquitin-protein ligase)", + "output": "Melanoma of the Conjunctiva pT2b TNM Finding v7 (Melanoma of the Conjunctiva Pathologic Primary Tumor TNM Finding v7)" + }, + { + "input": "Definition: Endoplasm described as one of two small cylindrical cell organelles composed of 9 triplet microtubules.\nConcepts: cryofixation (Procedures for reproductive medicine)\tTropheryma whipplei (Tropheryma)\tRAD51A (Gene or Genome)\tcentrioles (Serology)\tPQL0915 (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)", + "output": "centrioles (Serology)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the modulation of transcription.\nConcepts: Early Rheumatoid Arthritis (Disease or Syndrome)\tBorderline phyllodes tumour (Phyllodes Tumor)\tUndertaking a single task in a group (Functional Concept)\tFatigue associated with malignant neoplastic disease (Complication)\tBTB and CNC homology 1, basic leucine zipper transcription factor 2 (Transcription factor genes)", + "output": "BTB and CNC homology 1, basic leucine zipper transcription factor 2 (Transcription factor genes)" + }, + { + "input": "Definition: Bacterium described as a species of anaerobic, Gram positive, rod shaped bacteria assigned to the phylum Firmicutes. This species is sporulating, ferments glucose and xylose and produces butyric acid and acetic acid as fermentation by-products. C. tyrobutyricum is present in milk and causes late-blowing defect in cheeses with high pH leading to product loss.\nConcepts: MESO (Conceptual Entity)\tMethylophilus methylotrophus (Methylophilus)\tServices Insurance, Physician (Health Care Activity)\tFritillariae thunbergii / zhe bei mu (Oriental herbs and natural substances letter F)\tCLOSTRIDIUM TYROBUTYRICUM (Clostridium)", + "output": "CLOSTRIDIUM TYROBUTYRICUM (Clostridium)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of maltohexaose transport.\nConcepts: Study Site Planned Duration (Temporal Concept)\tdown regulation of maltohexaose transport (negative regulation of hexasaccharide transport)\tPowder and solution for bee-hive dispersion (Biomedical or Dental Material)\tQuite Concerned (Intellectual Product)\tMOL PROBE TECHNIQUE (Laboratory Procedure)", + "output": "down regulation of maltohexaose transport (negative regulation of hexasaccharide transport)" + }, + { + "input": "Definition: Carrier Proteins described as exportin-1 (1071 aa, ~123 kDa) is encoded by the human XPO1 gene. This protein plays a role in the mediation of nuclear export.\nConcepts: sensation disorders (Disease or Syndrome)\tCRM1 protein (Amino Acid, Peptide, or Protein)\tAbnormal circulating citrulline concentration (Finding)\tRefractory Medulloblastoma, SHH-Activated (Medulloblastoma, SHH-Activated)\tmetalloproteins (Protein, Organized by Structure)", + "output": "CRM1 protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as a standardized guideline developed by the Response Evaluation Criteria in Solid Tumors (RECIST) Working Group in 2000 and revised in 2009, which is an objective response criteria used to assess solid tumor response and to measure change in tumor size for use in adult and pediatric cancer clinical trials. Major revisions in RECIST version 1.1 includes lymph node (LN) measurement, the maximum number of target lesions, the definition of disease progression, as well as the inclusion of and guidance on the use of MRI and FDG PET in the detection of new lesions.\nConcepts: Scanning Laser Microscopy Cytometers (Medical Device)\tBeta-methylcrotonyglycinuria (Amino Acid Metabolism, Inborn Errors)\tAnnotations, Gene (Molecular Biology Research Technique)\tRECIST 1.1 (Response Evaluation Criteria in Solid Tumors)\tmedial vestibulospinal tract of the medulla (Body Part, Organ, or Organ Component)", + "output": "RECIST 1.1 (Response Evaluation Criteria in Solid Tumors)" + }, + { + "input": "Definition: something described as the terminology subset that includes terms pertaining to the CDISC clinical classification terminology.\nConcepts: Existential Therapy (Therapeutic or Preventive Procedure)\tCDISC Clinical Classification Terminology (Intellectual Product)\tIL-27B protein, human (Amino Acid, Peptide, or Protein)\tChronic diarrhea with hereditary sensory and autonomic neuropathy (Prion Diseases)\tRetrotransposon (Jumping Genes)", + "output": "CDISC Clinical Classification Terminology (Intellectual Product)" + }, + { + "input": "Definition: something described as a benign or malignant sympathetic paraganglioma arising from paraganglia outside the adrenal gland. Clinical symptoms are related to secretion of catecholamines. Representative examples include the superior and inferior paraaortic and bladder paragangliomas.\nConcepts: histone lysine H3 K79 dimethylation (Molecular Function)\tcold compress (Medical Device)\tSOWS Subjective (Handelsman) - My Muscles Twitch (SOWS Subjective Questionnaire Question)\tUndifferentiated Carcinoma with Osteoclast-Like Giant Cells (Undifferentiated carcinoma)\textra-adrenal pheochromocytoma (Extra-Adrenal Paraganglioma)", + "output": "extra-adrenal pheochromocytoma (Extra-Adrenal Paraganglioma)" + }, + { + "input": "Definition: something described as BIRDS that hunt and kill other animals, especially higher vertebrates, for food. They include the FALCONIFORMES order, or diurnal birds of prey, comprised of EAGLES, falcons, HAWKS, and others, as well as the STRIGIFORMES order, or nocturnal birds of prey, which includes OWLS.\nConcepts: granule cell axon (Cell Component)\tPrey Birds (Bird)\tPremarket Notification (Premarket Approval Application)\tATP diphosphohydrolase (nucleoside-triphosphate diphosphatase activity)\tMorphology (Biomedical Occupation or Discipline)", + "output": "Prey Birds (Bird)" + }, + { + "input": "Definition: Lipids measurement described as the determination of the amount of fatty acids present in a sample.\nConcepts: Slovak (Language commonly spoken in Europe)\tStudyProtocolVersion.studySchematic (Study Schematic)\tAbaloparatide (Parathyroid Hormone-Related Peptide Analog)\tFatty acids measurement (Laboratory Procedure)\tNA (Africa, Southern)", + "output": "Fatty acids measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as to rid of contamination.\nConcepts: heparan sulphate proteoglycan biosynthesis (heparan sulfate proteoglycan metabolic process)\tregulation of multivesicular body size involved in endosome transport (regulation of multivesicular body size)\tUterine Corpus Carcinoma and Carcinosarcoma FIGO Stage IIIC1 (Uterine Corpus Carcinoma and Carcinosarcoma Pathologic Regional Lymph Nodes TNM Finding v8)\tAccidental poisoning caused by cadmium and its compounds (Injury or Poisoning)\tDecontaminate (Action)", + "output": "Decontaminate (Action)" + }, + { + "input": "Definition: something described as a measurement of the heterozygous MB-type creatine kinase in a biological specimen.\nConcepts: Unknown (Finding)\tCPK MB (Cardiac enzymes measurement)\tinsular stem (Body Location or Region)\tVaccine associated measles (Disease or Syndrome)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(1;19)(q23;p13) PBX1/E2A (Indicator, Reagent, or Diagnostic Aid)", + "output": "CPK MB (Cardiac enzymes measurement)" + }, + { + "input": "Definition: Voice described as a wavering, unsteady voice that reflects involuntary and approximately sinusoidal oscillation of motor unit firings of laryngeal muscles. Vocal tremor results in low frequency modulations of voice frequency or amplitude and intermittent voice instability.\nConcepts: spermatogenesis (developmental process involved in reproduction)\tMSW (Master's Degree)\tenuresis (Bladder and urethral symptoms)\t1,3-dihydro-6-methyl-7-hydroxy-3-(4-chlorophenyl)furo(3,4-d)pyridine (C [Preparations])\tVocal tremor (Voice)", + "output": "Vocal tremor (Voice)" + }, + { + "input": "Definition: something described as t14: Conferences--To provide the chairman of the training committee funds for operation of the review group. T32: Institutional National Research Service Award -To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. Also see National Research Service Award (NRSA) Stipend Increase. T34: MARC Undergraduate NRSA Institutional Grants -To enable minority institutions to make National Research Service Awards to individuals selected by them for undergraduate research training in the biomedical and behavioral sciences. T35: NRSA Short-Term Research Training -To provide individuals with research training during off-quarters or summer periods to encourage research careers and/or research in areas of national need.\nConcepts: Physically available beds (Quantitative Concept)\tTraining Programs, T-Series (Funding Mechanism)\tCobJ (Molecular Function)\tStage III Merkel Cell Carcinoma (Merkel Cell Carcinoma by AJCC v7 Stage)\tOnecut Homeodomain Proteins (Homeodomain Proteins)", + "output": "Training Programs, T-Series (Funding Mechanism)" + }, + { + "input": "Definition: Myopathy described as a vague complaint of debility, fatigue, or exhaustion attributable to weakness of various muscles. The weakness can be characterized as subacute or chronic, often progressive, and is a manifestation of many muscle and neuromuscular diseases.\nConcepts: Weakness muscle (endocrine symptoms)\tMYD88 Leu265Pro (MYD88 Protein Variant)\tepimicrocellular nucleus (Body Part, Organ, or Organ Component)\tAdjustment disorder (Adjustment stress reaction syndrome)\tFAQ01-Playing a Game of Skill (Intellectual Product)", + "output": "Weakness muscle (endocrine symptoms)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of a solvent containing no active substances, intended for use in the preparation of a solution for intraocular irrigation. Comment: This term is only for use when describing a product that is authorised/marketed individually, and not to describe a manufactured item that is part of a product such as 'Powder and solvent for solution for intraocular irrigation'. In such cases, see instead 'Solvent for...'.\nConcepts: Solvent for Solution for Intraocular Irrigation Dosage Form (Biomedical or Dental Material)\t1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro- (Organic Chemical)\tPRKCBP1 (Transcription Repressor/Corepressor Gene)\tSATB Homeobox 1 wt Allele (Gene or Genome)\tGrade 1 Hepatobiliary disorders - Other, specify (Finding)", + "output": "Solvent for Solution for Intraocular Irrigation Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Antineoplastic Antibody described as a fully human combinatorial antibody library (HuCAL)-derived monoclonal antibody targeting the B-cell-activating factor receptor (BAFF-R), with potential anti-inflammatory and antineoplastic activities. Upon administration of HuCAL-based antibody VAY736, the antibody targets and binds to BAFF-R, which inhibits both BAFF/BAFF-R interaction and BAFF-R-mediated signaling. This may decrease cell growth in tumor cells expressing BAFF-R. BAFF-R, also known as tumor necrosis factor receptor superfamily member 13C, is overexpressed in certain tumor cell types and autoimmune diseases. In cancer cells, BAFF-R plays a key role in B-cell proliferation and survival. VAY736 was developed using HuCAL technology.\nConcepts: Belgian Laekenois (Non-Sporting Breed)\tCDISC SDTM Trial Blinding Schema Terminology (Intellectual Product)\trhamnetin 3'-O-methyltransferase activity (Molecular Function)\tSickle cell anemia with hemoglobin E disease (Common Hemoglobinopathies)\tHuCAL-based Antibody VAY736 (Immunologic Factor)", + "output": "HuCAL-based Antibody VAY736 (Immunologic Factor)" + }, + { + "input": "Definition: something described as this gene is involved in neuroblast migration and axon guidance.\nConcepts: SAX3 (Gene or Genome)\tQuality of Work Life (Qualitative Concept)\tGeneralized tonic-clonic seizures on awakening (Central Nervous System)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Urinary Bladder, Tumor Antigen (Medical Device)\tQLES216 (Q-LES-Q-SF Questionnaire Question)", + "output": "SAX3 (Gene or Genome)" + }, + { + "input": "Definition: Hematology described as a test result indicating the presence of red cells of various sizes and shapes in the peripheral blood.\nConcepts: mesodermal cell migration (Organ or Tissue Function)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Yersinia Species (Medical Device)\tAnisopoikilocytosis (Poikilocytosis)\tCongenital Phrenic Nerve Injury (Injury of phrenic nerve)\tEmbryonic Germ Cell (Cell)", + "output": "Anisopoikilocytosis (Poikilocytosis)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of thalidomide that may be used in the treatment of AIDS-related Kaposi sarcoma.\nConcepts: medial membrane band (cellular anatomical entity)\tConstrained Randomization (Adaptive Randomization)\tFellowship Programs, Cancer Prevention (Fellowship Program)\tThalidomide Regimen (Therapeutic or Preventive Procedure)\tcell fate commitment involved in formation of primary germ layer (Cell Function)", + "output": "Thalidomide Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Shared care prescribing described as drugs for dementia can be initiated by a specialist but continued to be prescribed by a general practitioner/primary care physician under a shared care prescribing arrangement.\nConcepts: 1: 150763524-150759820 (Chromosome 1 Physical Location)\tsedatives hypnotics (psychopharmacologic agent)\tnegative regulation of mammary gland development in males by androgen receptor signalling pathway (regulation of multicellular organismal development)\tMLL1 complex (Cell Component)\tShared care prescribing of drug for dementia (Finding)", + "output": "Shared care prescribing of drug for dementia (Finding)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 - During the past week: Has your physical condition or medical treatment interfered with your social activities?\nConcepts: Intestinal cryptosporidiosis (Opportunistic Infections)\tAngiomatoid Fibrous Histiocytoma (Fibromatous neoplasm)\tPRKM4 (MAP Kinase Gene)\tRetinoids (Pharmacologic Substance)\tEORTC QLQ-C30 Version 3 - Condition Interfered Social Activities (EORTC QLQ-C30 Version 3 Questionnaire Question)", + "output": "EORTC QLQ-C30 Version 3 - Condition Interfered Social Activities (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: something described as a gas liquid chromatography system for clinical use is a device intended to separate one or more drugs or compounds from a mixture. Each of the constituents in a vaporized mixture of compounds is separated according to its vapor pressure. The device may include accessories such as columns, gases, column supports, and liquid coating.\nConcepts: Gas Chromatography Systems (Chromatography Systems)\tSerratia liquefaciens Group (Serratia)\tKAT1 (Gene or Genome)\t3,3',5,5'-tetrabromobisphenol A reductive dehalogenase activity (oxidoreductase activity)\tmustard compounds (Hydrocarbons, Halogenated)", + "output": "Gas Chromatography Systems (Chromatography Systems)" + }, + { + "input": "Definition: Chromosome 22 Physical Location described as physical location of IL2RB_Gene\nConcepts: reduced flavine-adenine dinucleotide binding (Molecular Function)\tCentral Pontine Myelinoclasis (Degenerative brain disorder)\tamebiases (Disease or Syndrome)\t22: 35870462-35846382 (Spatial Concept)\tEye Movement Measurements (Diagnostic Techniques, Ophthalmological)", + "output": "22: 35870462-35846382 (Spatial Concept)" + }, + { + "input": "Definition: intrinsic component of plasma membrane described as the component of the synaptic membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.\nConcepts: Cross-sec Diameter, EVD (Finding)\tMitogen-Activated Protein Kinase Kinase Kinase Kinase 4 wt Allele (Gene or Genome)\tintrinsic component of synaptic membrane (intrinsic component of plasma membrane)\tMulti Energy Computed Tomography (X-Ray Computed Tomography)\tReagent (Indicator, Reagent, or Diagnostic Aid)", + "output": "intrinsic component of synaptic membrane (intrinsic component of plasma membrane)" + }, + { + "input": "Definition: Transcription Repressor/Corepressor Gene described as a fusion gene that results from a chromosomal rearrangement involving 12q13.3 and 12q13 which fuses the first 6 exons of the NAB2 gene in frame with exon 3, 17, or 18 of the STAT6 gene. This fusion is associated with solitary fibrous tumors.\nConcepts: Secondary Collapsing Glomerulopathy (Renal glomerular disease)\tlinogliride (Pharmacologic Substance)\tIntracellular Calcium-Sensing Proteins (Amino Acid, Peptide, or Protein)\tnegative regulation of transcription regulatory region DNA binding (negative regulation of DNA binding)\tNAB2-STAT6 Fusion Gene (Gene or Genome)", + "output": "NAB2-STAT6 Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as mild to moderate loss of bilateral lower extremity motor function, which may be a manifestation of SPINAL CORD DISEASES; PERIPHERAL NERVOUS SYSTEM DISEASES; MUSCULAR DISEASES; INTRACRANIAL HYPERTENSION; parasagittal brain lesions; and other conditions.\nConcepts: Burkitt Lymphoma by Ann Arbor Stage (Burkitt Lymphoma)\tBOC (Quantitative Concept)\tchinese (Asian - ethnic group)\tnegative regulation of synaptic vesicle clustering (regulation of synaptic vesicle clustering)\tPartial paralysis of legs (Physical findings)", + "output": "Partial paralysis of legs (Physical findings)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals.\nConcepts: CDISC ADAS-Cog - Delayed Word Recall: Word 7 (ADAS-Cog CDISC Version Questionnaire Question)\tDesmoplastic Infantile Ganglioglioma (Ganglioglioma)\tNiue (Geographic Area)\tanterior lateral line neuromast development (Organ or Tissue Function)\tparolfactory area (Body Part, Organ, or Organ Component)", + "output": "anterior lateral line neuromast development (Organ or Tissue Function)" + }, + { + "input": "Definition: Medical Device described as collection bags designed for collection of bile (fluid secreted by the liver and passed to the small intestine), for example, from a drainage tube inserted into the patient's duodenum. Bile collection bags are usually plastic or elastomeric single-use devices; patient-worn and independent bile collection bags are also available.\nConcepts: Kinanthropometries (Anthropometry)\tBile collection bag, device (Gastrointestinal tube)\tEar Occlusion Plug Dispensers (Dispenser)\tColon Carcinoma by AJCC v7 Stage (Colon Carcinoma)\tResidual Tumor Stage 2 (Intellectual Product)", + "output": "Bile collection bag, device (Gastrointestinal tube)" + }, + { + "input": "Definition: Infection described as histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons.\nConcepts: Unspecified histoplasmosis NOS (Histoplasmosis)\tTriangular end part of the middle bone of the middle finger (Anatomical Abnormality)\tStage IA1 (Intellectual Product)\tThoracic NUT Carcinoma (NUT midline carcinoma)\tSubdivision of limb (Subdivision of cardinal body part)", + "output": "Unspecified histoplasmosis NOS (Histoplasmosis)" + }, + { + "input": "Definition: Medical Device described as an artificial embolization device is an object that is placed in a blood vessel to permanently obstruct blood flow to an aneurysm or other vascular malformation.\nConcepts: Left eye (Orbital region)\tDEVICE, ARTIFICIAL EMBOLIZATION (Medical Device)\tWORSENED END-ORGAN PERFUSION (Cardiovascular finding)\thistone H4-K16 acetylation (histone H4 acetylation)\tZone of circumflex branch of left coronary artery (Body Location or Region)", + "output": "DEVICE, ARTIFICIAL EMBOLIZATION (Medical Device)" + }, + { + "input": "Definition: Dose form by site prepared for described as a substance intended for administration by injection.\nConcepts: TSPY-Like Protein 5 (Ubiquitination Regulation Protein)\tSocket Adapter Device (Adapter Device)\tInjectable (Dosage Forms)\tBiologic Entity Part Quantity Range (Quantitative Concept)\tThorium oxide (Inorganic Chemical)", + "output": "Injectable (Dosage Forms)" + }, + { + "input": "Definition: biology described as the study of the structure of various TISSUES of organisms on a microscopic level.\nConcepts: SNCB protein, human (Biologically Active Substance)\thistologies (Thesaurus of Psychological Index Terms)\tSyndromes, SUNCT (Trigeminal Autonomic Cephalalgias)\troundworm (Phylum Nematoda)\tBrainLab iPlan (Computer Systems)", + "output": "histologies (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a regimen consisting of fluorouracil, doxorubicin and methotrexate used for the treatment of advanced-stage gastric cancer.\nConcepts: Doxorubicin/Fluorouracil/Methotrexate (Regimen Used to Treat Gastric Carcinoma)\tCatheters, Spinal, Intervertebral Disc, Electrothermal Cautery (Spinal catheter)\tLiving with Uncle (Living Arrangements)\tnegative regulation of glomerular mesangial cell proliferation (Cell Function)\tdown-regulation of autophagosome biosynthesis (regulation of autophagosome assembly)", + "output": "Doxorubicin/Fluorouracil/Methotrexate (Regimen Used to Treat Gastric Carcinoma)" + }, + { + "input": "Definition: Gastrointestinal infections, site unspecified described as an abscess within the abdomen.\nConcepts: Abdominal abscess, NOS (Abdominal Infection)\tdiadenosine polyphosphate metabolism (Molecular Function)\tRNA-protein covalent cross-linking via peptidyl-serine (peptidyl-serine modification)\tETRP0103 (Intellectual Product)\tcentromeric mitotic sister chromatin cohesion (Mitotic Sister Chromatid Cohesion)", + "output": "Abdominal abscess, NOS (Abdominal Infection)" + }, + { + "input": "Definition: Tanner Scale-Girl Clinical Classification Question described as an assessment and classification of the development of breasts in girls that is based on the Tanner Scale of pubertal changes in girls (Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969 Jun; 44(235): 291-303).\nConcepts: aflatoxin B1 (Aflatoxins)\tstreptococcinum bacteria/str (Organic Chemical)\tAortic Preductal Coarctation Severity (Cardiovascular finding)\tSPMAGGR (Laboratory Procedure)\tTanner Scale for Girls, Breast Stage (Tanner Scale-Girl Clinical Classification Question)", + "output": "Tanner Scale for Girls, Breast Stage (Tanner Scale-Girl Clinical Classification Question)" + }, + { + "input": "Definition: Rehabilitative treatments and/or training described as assisting a client in performing therapeutic exercise to obtain, restore and/or improve his or her normal function of a body part or region that requires rehabilitation. Service is billed in 15-minute increments.\nConcepts: Masaoka-Koga Stage III (Thymoma by Masaoka-Koga Stage)\tLeukemia NOS in relapse (leukemia)\ttermination of RNA polymerase II transcription, poly(A)-coupled (Genetic Function)\tFatigue Interferes with Work (Intellectual Product)\tsistvTHERAP.ex ndvdl ea.15mi (Therapeutic or Preventive Procedure)", + "output": "sistvTHERAP.ex ndvdl ea.15mi (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of melanoma of the conjunctiva, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.\nConcepts: How Much Does Illness and/or Treatment Interfere with Financial Situation (Intellectual Product)\tNasal Cavity and Ethmoid Sinus Cancer Pathologic Regional Lymph Nodes TNM Finding v6 (Finding)\tpmol/L/h (Molality Unit)\tBrivanib Alaninate (Protein-tyrosine kinase inhibitor)\tMelanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7 (Melanoma of the Conjunctiva Clinical TNM Finding v7)", + "output": "Melanoma of the Conjunctiva Clinical Distant Metastasis TNM Finding v7 (Melanoma of the Conjunctiva Clinical TNM Finding v7)" + }, + { + "input": "Definition: Kidney Cancer Pathologic Regional Lymph Nodes TNM Finding v8 described as kidney cancer with no regional lymph node metastasis.\nConcepts: radiation fibrosis (cancer-related problem/condition)\tADENOVIRUS E01A PROTEINS (TRANSCRIPTION FACTOR)\tKleeblattschaedel (Skull)\tMetastatic Breast Carcinoid Tumor (Metastatic carcinoid tumor)\tKidney Cancer pN0 TNM Finding v8 (Kidney Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Kidney Cancer pN0 TNM Finding v8 (Kidney Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: something described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale - Aids or devices that you usually use for any of these activities: Built up or special utensils.\nConcepts: Pharbitidis / qian niu zi (Plant)\tdown-regulation of satellite cell proliferation (regulation of skeletal muscle satellite cell proliferation)\tEMO1-Neutral Responded as Sadness (ERT Functional Test Question)\tHAQ0215 (Intellectual Product)\tpediatric acute M3 leukemia (Childhood Acute Myeloid Leukemia)", + "output": "HAQ0215 (Intellectual Product)" + }, + { + "input": "Definition: Periventricular Leukomalacia, Adverse Event described as an adverse event in a newborn characterized by periventricular echodensities, evolving in to extensive cystic periventricular lesions; or densities extending in to the deep white matter.\nConcepts: Grade 3 Periventricular Leukomalacia (Periventricular Leukomalacia, Adverse Event)\tMedicare Severity-Diagnosis Related Group (Computer Systems)\tCYTOCHROME c OXIDASE, SUBUNIT 6C (Gene or Genome)\tRectus Femoris (Structure of quadriceps femoris muscle)\tMercapturic acid (acetylcysteine)", + "output": "Grade 3 Periventricular Leukomalacia (Periventricular Leukomalacia, Adverse Event)" + }, + { + "input": "Definition: Phenomenon or Process described as continuous physical force exerted on an object by something in contact with it.\nConcepts: dental hypnosis (Dental anesthesia)\tStrychnine Tree Seed (Plant)\tIVD Test Reagent/Kits, Immunoassay, Standard, Autoimmune Disease (IVD Test Reagent/Kits, Immunoassay, Standard)\tPressure- physical agent (Pulmonary ventilator management)\tDiapedesis, function (Vascular function)", + "output": "Pressure- physical agent (Pulmonary ventilator management)" + }, + { + "input": "Definition: something described as a non-SI unit of energy defined as the amount of heat required to raise the temperature of one gram of pure water by one degree (from 3.5 to 4.5 C or from 276.65 to 277.65 K) under standard conditions with the specific heat of the water at 4 degrees Celsius and the constant pressure of 101.325 kPa or one atm being defined as unity. A value of the calorie at 4 degrees Celsius is defined as 4.2045 J. According to the current national standard in the United States (IEEE/ASTM SI 10TM 2002. American National Standard for Use of the International System of Units (SI): The Modern Metric System, New York: IEEE, 2002) the calorie in any form is not to be used. Joules should be used instead.\nConcepts: Calorie 4 Degrees Celsius (Calorie Unit)\tLinaria (Plant)\tplasma membrane raft polarization (Cell Function)\tEstrogen Receptor Agonist GTx-758 (Amino Acid, Peptide, or Protein)\tLanguage NOS (Cognitive functions)", + "output": "Calorie 4 Degrees Celsius (Calorie Unit)" + }, + { + "input": "Definition: Finding described as hypopharyngeal cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).\nConcepts: Urothelial carcinoma, NOS (Cancer of Urinary Tract)\tresponse to interleukin-32 (response to cytokine)\tHypopharyngeal Carcinoma pN2c TNM Finding v8 (Finding)\t3-oxo-cerotoyl-CoA synthase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tWHODAS 2.0 12-item Version Self-administered - Dealing With People You Do Not Know (Intellectual Product)", + "output": "Hypopharyngeal Carcinoma pN2c TNM Finding v8 (Finding)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate.\nConcepts: glucose 1-phosphate transphosphorylase activity (phosphotransferase activity, alcohol group as acceptor)\tClark Level IV (Clark's melanoma level)\tKanamycin Resistance (Drug Resistance, Bacterial)\tOptical density measurement (Optical Methods)\tOwls (Raptors)", + "output": "glucose 1-phosphate transphosphorylase activity (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: Finding described as minimal dyspnea; findings on physical exam or other evaluation\nConcepts: Grade 1 Pulmonary Hypertension, CTCAE (Pulmonary Hypertension, CTCAE)\tTFG-NR4A3 Fusion Gene (Signaling Pathway Gene)\tBB VITAMINS (Challenge tests)\t2-(4-(2-((3,5-dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid (Radiation-Sensitizing Agents)\tBroad Ligament Serous Adenocarcinoma (Uterine Ligament Serous Adenocarcinoma)", + "output": "Grade 1 Pulmonary Hypertension, CTCAE (Pulmonary Hypertension, CTCAE)" + }, + { + "input": "Definition: Medical Device described as snares designed to position and tighten fine-gauge, flexible, adjustable wire loops around a region of nasal tissue for mechanical or electrosurgical resection and hemostasis. These devices typically consist of a hollow tubular structure (e.g., a cannula), with one or more adjustable wire loops (rings) that protrude at the working end; frequently they include a stationary loop and a sliding loop. A mechanism at the proximal end (handle) controls how much wire extends out of the channel and the movement of the sliding (cutting) loop as the loop is withdrawn into the cannula; the handle may be straight (e.g., Krause type) to the cannula or offset (bayonet type, also known as Lange type). Nasal snares may be single-use (i.e., disposable) or reusable; they are used mainly to remove polyps, tumors, and other abnormal tissue from the nasal cavities.\nConcepts: Inheres in (Concept model attribute)\tCBP80 Protein (Amino Acid, Peptide, or Protein)\tPicolines (Pyridines)\tSource Data Verification (Functional Concept)\tSNARE, NASAL (Medical Device)", + "output": "SNARE, NASAL (Medical Device)" + }, + { + "input": "Definition: something described as catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.\nConcepts: transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer (acyltransferase activity)\tPSO2 homolog (DNA Repair Gene)\tPHOSPHOGLYCERATE MUTASE (COLORIMETRIC), 2,3-DIPHOSPHOGLYCERIC ACID (Indicator, Reagent, or Diagnostic Aid)\tdefence response to Gram-positive bacterium (defense response to bacterium)\tSyringe/Needle Destroyers (Reusable Devices)", + "output": "transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer (acyltransferase activity)" + }, + { + "input": "Definition: Finding described as bladder cancer with distant metastasis.\nConcepts: Have Adequate Moisture in Mouth (Findings-Based Question)\tYb body (cellular anatomical entity)\tVascular thrombosis (Soft tissue lesion)\tSubcapsular opacities (Vision Disorders)\tBladder Carcinoma pM1 TNM Finding v8 (Bladder Cancer Pathologic Distant Metastasis TNM Finding v8)", + "output": "Bladder Carcinoma pM1 TNM Finding v8 (Bladder Cancer Pathologic Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: Functional Concept described as diagrams in which interactions between group members are analyzed on the basis of mutual attractions or antipathies.\nConcepts: parieto-dependent motor areas (Body Part, Organ, or Organ Component)\tUnresectable Gallbladder Carcinoma (stage, gallbladder cancer)\tSociograms (Sociometric Techniques)\tMicroscopes, Light, Laboratory, Darkfield (Medical Device)\tneurotoxicity syndromes (Poisoning)", + "output": "Sociograms (Sociometric Techniques)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: glycerol + diphosphate = glycerol 1-phosphate + H(+) + phosphate.\nConcepts: FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Fast 50 Steps (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tMicrogram/Hour (Unit of Mass Flow Rate)\tVitellin (Phosphoproteins)\tFamilial papillary thyroid carcinoma with renal papillary neoplasia syndrome (Malignant epithelial neoplasm of thyroid)\tdiphosphate-glycerol phosphotransferase activity (Molecular Function)", + "output": "diphosphate-glycerol phosphotransferase activity (Molecular Function)" + }, + { + "input": "Definition: Functional finding described as a sighted guide is a person that escorts a visually impaired individual and assists them with for example reading of signs.\nConcepts: Requires sighted guide (Functional finding)\tLISSENCEPHALY SYNDROME, NORMAN-ROBERTS TYPE (Hereditary Connective Tissue Disorder)\tGanglioglioma, NOS (Neoplasms, Neuroepithelial)\tMonkeys, Patas (Cercopithecidae)\tPHQ0304K (PHQ Screener Version Questionnaire Question)", + "output": "Requires sighted guide (Functional finding)" + }, + { + "input": "Definition: integral component of mitochondrial membrane described as the component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.\nConcepts: integral component of mitochondrial outer membrane (integral component of mitochondrial membrane)\tPerformedGeneticObservationResult.alleleIndicatorCode (Allele Indicator Code)\tHistory of preeclampsia (History of gestational hypertension)\tcholine kinase alpha inhibitor TCD-717 (Enzyme Inhibitor Drugs)\tDens of axis (Entire body of cervical vertebra)", + "output": "integral component of mitochondrial outer membrane (integral component of mitochondrial membrane)" + }, + { + "input": "Definition: Disease described as a syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis.\nConcepts: Akureyri disease (Chronic disease)\tmorphology (Biomedical Occupation or Discipline)\tLeukocyte Adherence Inhibition Test (Immunologic Tests)\tL-alanine degradation, by transamination (Molecular Function)\tTSCYC1-Being Easily Scared (TSCYC Questionnaire Question)", + "output": "Akureyri disease (Chronic disease)" + }, + { + "input": "Definition: something described as human PAX2 wt allele is located in the vicinity of 10q24.31 and is approximately 84 kb in length. This allele, which encodes paired box protein Pax-2, plays a role in transcription by RNA Polymerase II and in development of the central nervous system, eyes, kidney and urogenital tract.\nConcepts: Paired Box 2 wt Allele (Gene or Genome)\tHelped and Using It Sometimes (Intellectual Product)\tnucleic acid quantitation/detection (analytical method)\tMicrococcus Cohn 1872 emend. Stackebrandt et al. 1995 (Bacterium)\tBeta-2 microglobulin (protein) level (Protein measurement)", + "output": "Paired Box 2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Aspiration of skin and/or subcutaneous tissue described as the removal of excess fat deposits from the body.\nConcepts: Hemoglobin D/Total Hemoglobin (Hemoglobin measurement)\tSuction Lipolysis (Procedure categorized by device involved)\tBlue Citrus-Based Herbal Capsule (Pharmacologic Substance)\tCertainty that Good Outweighs the Bad Things About Medication (Intellectual Product)\tpiRNA metabolic process (ncRNA metabolic process)", + "output": "Suction Lipolysis (Procedure categorized by device involved)" + }, + { + "input": "Definition: INO80D gene described as human INO80D wild-type allele is located in the vicinity of 2q33.3 and is approximately 93 kb in length. This allele, which encodes INO80 complex subunit D protein, is involved in chromatin remodeling.\nConcepts: Floors and Floorcoverings (Facility Design and Construction)\thexose phosphate transmembrane transporter activity (Molecular Function)\tcerebellar climbing fibre to Purkinje cell synapse (Cell Component)\tINO80 Complex Subunit D wt Allele (Gene or Genome)\tGRAM NEG OXYGENIC PHOTOSYN BACT (Gram Negative Bacteria)", + "output": "INO80 Complex Subunit D wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as a measurement (expressed as a fraction or percent) of the number of live female fetuses to the total number of live male and female fetuses.\nConcepts: Fetal Female Sex Ratio (Ratio)\tallose biosynthesis (Molecular Function)\troot hair elongation (developmental growth involved in morphogenesis)\tCRQ01-Felt Worn Out or Sluggish (CRQ-SAS First Administration Version Questionnaire Question)\tAirway Remodelings (Pathological Conditions, Anatomical)", + "output": "Fetal Female Sex Ratio (Ratio)" + }, + { + "input": "Definition: Neoplastic Process described as a rare adenocarcinoma that arises from the vagina with histologic features resembling cervical mucinous adenocarcinoma, endocervical type or cervical mucinous adenocarcinoma, intestinal variant.\nConcepts: Vaginal Mucinous Adenocarcinoma (Mucinous Adenocarcinoma)\tThrombophlebitis (Venous thrombosis, phlebitis and thrombophlebitis)\tFetal Heart Tone Location (Finding)\tHybrid Argon Plasma Coagulation (Therapeutic or Preventive Procedure)\tShaver Systems, Arthroscopic (Electromechanical Devices)", + "output": "Vaginal Mucinous Adenocarcinoma (Mucinous Adenocarcinoma)" + }, + { + "input": "Definition: Neoplastic Process described as a B-cell non-Hodgkin lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin lymphoma.\nConcepts: Treacher Collins Syndrome Protein (Amino Acid, Peptide, or Protein)\tICD-O-2 (Intellectual Product)\tLumbosacral Region (Trunk structure)\tGerminoblastic sarcoma, diffuse (Diffuse high grade B-cell lymphoma)\tFlibanserin (benzimidazole)", + "output": "Germinoblastic sarcoma, diffuse (Diffuse high grade B-cell lymphoma)" + }, + { + "input": "Definition: Health Care Related Organization described as conducts and supports an integrated program of the highest quality genetic, epidemiological, behavioral, social, applied, and surveillance cancer research.\nConcepts: chemoembolization (Pharmacotherapy)\t2-chloroacrylate reductase activity (Molecular Function)\tDivision of Cancer Control and Population Sciences (Component of the National Cancer Institute)\tValine measurement, NOS (Laboratory Procedure)\tSH3 domain binding (protein domain specific binding)", + "output": "Division of Cancer Control and Population Sciences (Component of the National Cancer Institute)" + }, + { + "input": "Definition: modulation by virus of host immune response described as any viral process that results in the inhibition of interferon activity within the host cell.\nConcepts: gossypium hrbaceum/cotton/le (Western herbs and natural substances letter G)\tsuppression by virus of host intracellular interferon activity (modulation by virus of host immune response)\tASB-2 protein, human (Biologically Active Substance)\tVFQ2-Rate Your Eyesight Now (Intellectual Product)\tAnti-Factor Xa Activity Measurement (Laboratory Procedure)", + "output": "suppression by virus of host intracellular interferon activity (modulation by virus of host immune response)" + }, + { + "input": "Definition: Biologic Function described as any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.\nConcepts: CSS03-Most Severe Idea, Frequency-P6M (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tGlyoxylate (Organic Chemical)\tKadish Stage B Olfactory Neuroblastoma (Olfactory Neuroblastoma)\tregulation of establishment of planar polarity (Biologic Function)\tsplnting (Other immobilization, pressure, and attention to wound)", + "output": "regulation of establishment of planar polarity (Biologic Function)" + }, + { + "input": "Definition: Perceived quality of life described as freedom from control or influence of another or others factors.\nConcepts: Independent (Perceived quality of life)\tCLG (Metallopeptidase Gene)\tTherapeutic Estetrol (Pharmacologic Substance)\tIRF3:IRF5 complex (Cell Component)\tTumor Suppressor Arf Inhibits Ribosomal Biogenesis (Metabolic Pathway)", + "output": "Independent (Perceived quality of life)" + }, + { + "input": "Definition: Embryonic Structure described as cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).\nConcepts: trophoblasts (Cells)\tInoculating Loop Incinerators (Autoclave)\talpha9-beta1 integrin-ADAM12 complex location (Cell Component)\tHostility/aggression (Classification)\tCTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity (Molecular Function)", + "output": "trophoblasts (Cells)" + }, + { + "input": "Definition: Cell Component described as a protein complex formed by the association of the small GTPase Cdc42 with additional proteins. In Schizosaccharomyces the complex contains the Cdc42, Ras1, Scd1, Scd2, andShk1 proteins, and functions in the Ras1-Scd GTPase signalling pathway.\nConcepts: Cdc42 GTPase complex location (Cell Component)\tIndeterminate Continuous Cardiotocography Pattern (Test Result)\tup-regulation of antibody-dependent cellular cytotoxicity (Cell Function)\tUnit of Gravity (Unit of force)\tinhibition of endoderm cell differentiation (negative regulation of gastrulation)", + "output": "Cdc42 GTPase complex location (Cell Component)" + }, + { + "input": "Definition: Medical Device described as toxoplasma gondii serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Toxoplasma gondii in serum. Additionally, some of these reagents consist of antisera conjugated with a fluorescent dye (immunofluorescent reagents) used to identify Toxoplasma gondii from clinical specimens. The identification aids in the diagnosis of toxoplasmosis caused by the parasitic protozoan Toxoplasma gondii and provides epidemiological information on this disease. Congenital toxoplasmosis is characterized by lesions of the central nervous system, which if undetected and untreated may lead to brain defects, blindness, and death of an unborn fetus. The disease is characterized in children by inflammation of the brain and spinal cord.\nConcepts: DLQI - Skin Made Difficult to Do Sport (DLQI Questionnaire Question)\tTP1 (Regulatory Protein)\tPeriodic paralysis II (Myotonic Disorders)\tDyskinesia (Classification)\tANTISERA, IF, TOXOPLASMA GONDII (Medical Device)", + "output": "ANTISERA, IF, TOXOPLASMA GONDII (Medical Device)" + }, + { + "input": "Definition: Pharmacologic Substance described as a dendritic cell (DC) vaccine in which autologous DCs are loaded with multiple tumor-associated antigens (TAAs), with potential immunostimulating and antineoplastic activities. Upon re-infusion into the patient, the antigen-pulsed DCs stimulate the immune system to mount a specific cytotoxic T-lymphocyte (CTL) response against the TAA-expressing tumor cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C131336\" active clinical trials using this agent.\nConcepts: ANTISERA, FLUORESCENT ANTIBODY FOR FTA-ABS TEST (Indicator, Reagent, or Diagnostic Aid)\tTranslation Process Gene (Gene or Genome)\tAggressive Recurrent Adult Non-Hodgkin's Lymphoma (Neoplastic Process)\tsec*mcmol/mL (Quantitative Concept)\tMultiple Target Antigen-stimulating Cells-I (Pharmacologic Substance)", + "output": "Multiple Target Antigen-stimulating Cells-I (Pharmacologic Substance)" + }, + { + "input": "Definition: Antineoplastic Agents described as a proprietary agent that targets the cancer stem cell (CSC) antigen CD44, with potential antineoplastic activity. Although the mechanism of action has not been elucidated, following subcutaneous administration, CD44 targeted agent SPL-108 binds to CD44 and prevents the activation of various CD44-mediated signal transduction pathways, which may lead to reduced proliferation of CD44-expressing tumor stem cells. CD44, a transmembrane glycoprotein and hyaluronic acid receptor, is expressed in healthy tissue and overexpressed in numerous cancer cell types; it plays a key role in the proliferation, migration and survival of tumor cells.\nConcepts: am (Unit of length)\tceramide carrier activity (sphingolipid transfer activity)\tSPL-108 (Antineoplastic Agents)\tdelavirdine mesylate (Reverse Transcriptase Inhibitors)\tGrade 3 Bronchospasm, CTCAE (Bronchospasm, CTCAE)", + "output": "SPL-108 (Antineoplastic Agents)" + }, + { + "input": "Definition: something described as an allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.\nConcepts: CDISC Clinical Classification West Haven Criteria Test Code Terminology (CDISC Clinical Classification Terminology)\tD-2-hydroxyglutarate dehydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)\tFollowed (Health Care Activity)\t6PF2K (Phosphoric Monoester Hydrolases)\tBorrelia burgdorferi antibody assay (Laboratory Procedure)", + "output": "6PF2K (Phosphoric Monoester Hydrolases)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - Was {S} left: at home for less than 1 hour during the day?\nConcepts: Carcinoma in situ of Pylorus of Stomach (Neoplastic Process)\tMalignant Superior Sulcus Neoplasm (Malignant neoplasm of lung)\tTriptorelin (Hypothalamic Releasing Factor)\tglucuronate metabolic process (Molecular Function)\tADCS-ADL Severe Dementia - Alone at Home for Less Than One Hour (Intellectual Product)", + "output": "ADCS-ADL Severe Dementia - Alone at Home for Less Than One Hour (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reaction: L-histidine = urocanate + NH3.\nConcepts: alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile (Pharmacologic Substance)\tWoods syndrome (Disease or Syndrome)\tL-histidine ammonia-lyase (ammonia-lyase activity)\tAmt Rec Infinity Obs (Quantitative Concept)\tcancer of brain (Neoplasms)", + "output": "L-histidine ammonia-lyase (ammonia-lyase activity)" + }, + { + "input": "Definition: Mental Process described as using the body's other basic senses intentionally to experience stimuli, such as touching and feeling textures, tasting sweets or smelling flowers.\nConcepts: Other purposeful sensing (Purposeful sensory experiences)\tQ-LES-Q - Interested in Your Course Work (Intellectual Product)\tcholine monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Vibrio Species (Medical Device)\tHaemophilus actinomycetemcomitans (Bacterium)", + "output": "Other purposeful sensing (Purposeful sensory experiences)" + }, + { + "input": "Definition: something described as complex of organisms forming a community, together with all interacting physical factors of the environment, to form a single functioning unit.\nConcepts: chemotaxis to folate (response to folic acid)\tJoint unsteady (Mechanical joint disorder)\tDrug.handlingCode (Intellectual Product)\tEcologic Systems (Ecology)\tIncreased circulating myelocyte count (Increased circulating immature neutrophil count)", + "output": "Ecologic Systems (Ecology)" + }, + { + "input": "Definition: Molecular Target Inhibitors described as an orally available Raf kinase inhibitor with potential antineoplastic activity. Encorafenib specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of encorafenib may result in a decrease in proliferation of tumor cells. The Raf mutation BRAF V600E is frequently upregulated in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C98283\" active clinical trials using this agent.\nConcepts: encorafenib (BRAF inhibitor)\tPolyelectrolyte (Polymers)\tElectrodes, Blood Gas, Carbon Dioxide (Medical Device)\tIntelligent Tutoring Systems (Machine Activity)\tTransient Gene Knock-Out Model (Experimental Model of Disease)", + "output": "encorafenib (BRAF inhibitor)" + }, + { + "input": "Definition: Health Risk Assessment described as models connecting initiating events at the cellular and molecular level to population-wide impacts. Computational models may be at levels relating toxicology to adverse effects.\nConcepts: Skin Response Data Collection Date Time (Collection Date Time)\tAdverse Outcome Pathway (Health Risk Assessment)\tLVOTPVEL (Cardiovascular finding)\tMolecular layer of cerebellar cortex (Cerebellar cortex structure)\tLocally Advanced Breast Carcinoma (Metastatic Breast Carcinoma)", + "output": "Adverse Outcome Pathway (Health Risk Assessment)" + }, + { + "input": "Definition: negative regulation of cell migration described as any process that stops, prevents or reduces the frequency, rate or extent of fibroblast chemotaxis.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Drug-of-Abuse, Cannabinoid/Cannabinoid Metabolite (Medical Device)\tSubchondral Arthroplasty (Therapeutic or Preventive Procedure)\tMicrogram per Milliliter per Milligram per Meter Squared (Quantitative Concept)\tGENE EXPRESSION REG ENZYMOL (Gene Expression Regulation)\tdown-regulation of fibroblast chemotaxis (negative regulation of chemotaxis)", + "output": "down-regulation of fibroblast chemotaxis (negative regulation of chemotaxis)" + }, + { + "input": "Definition: Human Papilloma Virus Vaccine described as a peptide based vaccine consisting of amino acids 12 through 20 of the E7 gene of the Human Papilloma Virus type 16. HPV-16 E7 12-20 peptide vaccine may elicit a specific CD8 T-cell response to the E7 oncogene protein, thereby inhibiting the abrogation of p53 and pRb function and thus prevent tumorigenesis.\nConcepts: football (Daily or Recreational Activity)\tEndomyces (Saccharomycetales)\tHPV 16 E7:12-20 peptide vaccine (Human Papilloma Virus Vaccine)\tarea 9 of Walker (Body Location or Region)\tCamelid, New World (Camelidae)", + "output": "HPV 16 E7:12-20 peptide vaccine (Human Papilloma Virus Vaccine)" + }, + { + "input": "Definition: Mucinous Adenocarcinoma described as a rare adenocarcinoma that arises from the salivary glands, most frequently the soft palate and the sublingual gland. It is characterized by the presence of large pools of extracellular mucin in which clusters of malignant epithelial cells are found. Patients usually present with a slow growing mass. It tends to recur locally and metastasize to regional lymph nodes.\nConcepts: mucinous adenocarcinoma of salivary gland (Adenocarcinoma of salivary gland)\ttransmembrane L-cystine transport from lysosomal lumen to cytosol (L-cystine transport)\tinjury; lung (Parenchymal lung disorders NEC)\tfusion of viral membrane with host outer nuclear membrane involved in nuclear egress (multi-organism membrane fusion)\tprominosome (Extracellular Vesicles)", + "output": "mucinous adenocarcinoma of salivary gland (Adenocarcinoma of salivary gland)" + }, + { + "input": "Definition: Drusen described as drusen (singular, 'druse') are tiny yellow or white accumulations of extracellular material (lipofuscin) that build up in Bruch's membrane of the eye. This class refers to the presence of Drusen in the macula.\nConcepts: middle ear (EARS AND MASTOID CELLS)\tcaudal part of the thoracic column (Body Part, Organ, or Organ Component)\tClamps, Surgical, Vascular, Hemorrhoid (Medical Device)\tQUALITATIVE FOOD CONSUMPTION (Intellectual Product)\tmacula; drusen (Drusen)", + "output": "macula; drusen (Drusen)" + }, + { + "input": "Definition: Qualitative Concept described as located outside of the bone.\nConcepts: dynein heavy chain binding (Molecular Function)\tmultinodular goitre 1 (Endoribonuclease Gene)\tSkin Staplers (Surgical Instruments)\textraosseous (Anatomy Qualifier)\tundecaprenyl-phosphate glucose phosphotransferase activity (Molecular Function)", + "output": "extraosseous (Anatomy Qualifier)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the BCR/PDGFRA fusion gene. This protein is comprised of the N-terminal oligomerization domain of the breakpoint cluster region protein fused to the C-terminal intracellular domain of the alpha-type platelet-derived growth factor receptor precursor protein, including the tyrosine kinase domains.\nConcepts: erythema; induratum, tuberculous (Connective Tissue Diseases)\tMuscle eye brain disease with bilateral multicystic leucodystrophy (Leukodystrophy)\tBCR/PDGFRA Fusion Protein (Fusion protein)\tFLUORESCENT PROC. (QUAL.), GALACTOSE-1-PHOSPHATE URIDYL TRANSFERASE (Medical Device)\tAdditional Sex Combs Like 1 Gene Mutation (Gene Mutant)", + "output": "BCR/PDGFRA Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Organism Attribute described as a relative measurement (ratio) of the waist circumference to the hip circumference.\nConcepts: Waist to hip ratio (Personal Attribute)\tBody System, Cardiovascular (Adult human body)\tVeterans Health Service (Organization and Administration)\tethanol breakdown (drug catabolic process)\tRES complex location (Genetic Function)", + "output": "Waist to hip ratio (Personal Attribute)" + }, + { + "input": "Definition: Adrenergic Agents described as an ethanolamine derivative with bronchodilating and tocolytic activities. Terbutaline selectively binds to and activates beta-2 adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric G protein and subsequent increase in cyclic AMP (cAMP) production. Increased cAMP levels result in relaxation of bronchial and vascular smooth muscle mediated through the activation of protein kinase A (PKA), which phosphorylates proteins in control of muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces calcium entry into cells and induces the sequestration of intracellular calcium all of which aids in the relaxation of airway muscles. Terbutaline also increases mucociliary clearance and reduces release of inflammatory cell mediators.\nConcepts: Terbutaline product (Selective beta-2-adrenoreceptor agonist inhalants)\tfructose 2,6-bisphosphate metabolism (organophosphate metabolic process)\tC7 Complement (COMPLEMENT COMPONENTS AND FACTORS)\tglobose nucleus development (Organ or Tissue Function)\tresponse to stilbenoid (response to organic cyclic compound)", + "output": "Terbutaline product (Selective beta-2-adrenoreceptor agonist inhalants)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the region of the prostate that is located on the anatomical left side of the anterior portion of the apical division of the peripheral zone.\nConcepts: PCL0115 (Intellectual Product)\tregulation of mitotic chromosome decondensation (regulation of mitotic sister chromatid segregation)\tStructure of anterior apical part of peripheral zone of left half prostate (Left apical peripheral zone of prostate)\tMilligram per Deciliter (Quantitative Concept)\tC-SSRS Pediatric/Cognitively Impaired Lifetime/Recent - Most Recent Suicide Attempt Potential Lethality (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)", + "output": "Structure of anterior apical part of peripheral zone of left half prostate (Left apical peripheral zone of prostate)" + }, + { + "input": "Definition: Component of the National Institutes of Health described as an institute within the National Institutes of Health that is mandated to conduct and support biomedical and behavioral research and research training in the normal and disordered processes of hearing, balance, smell, taste, voice, speech, and language.\nConcepts: Physiologic Monitor Modules, Electroencephalography (Physiologic Monitor Modules)\tBacterial Casts (Urine Sediment Analysis Measurement)\tdouble-strand break repair via single-strand annealing, removal of nonhomologous ends (Genetic Function)\tDysopia (Visual Manifestations)\tNational Institute on Deafness and Other Communication Disorders (Component of the National Institutes of Health)", + "output": "National Institute on Deafness and Other Communication Disorders (Component of the National Institutes of Health)" + }, + { + "input": "Definition: something described as functions of the nails, such as protection, scratching and appearance.\nConcepts: Meprobamate product (Sedatives)\tAGP7 (PRTN3 gene)\tCYP2D6*41 (CYP2D6 gene)\tFunctions of nails (Functions of the hair and nails)\tAVL01010 (Intellectual Product)", + "output": "Functions of nails (Functions of the hair and nails)" + }, + { + "input": "Definition: something described as a valve made of animal tissues or harvested from human cadavers and used to replace the mitral valve in patients with mitral valve stenosis or regurgitation.\nConcepts: Analytic Sample Preparation Methods (Investigative Techniques)\tarea FCop of Bonin (Body Location or Region)\tsensory detection of chemical stimulus during perception of umami taste (detection of chemical stimulus involved in sensory perception of taste)\timmunoglobulin production involved in immunoglobulin mediated immune response (Antibody Formation)\tTissue Mitral Valve (Medical Device)", + "output": "Tissue Mitral Valve (Medical Device)" + }, + { + "input": "Definition: Molecular Function described as a negative regulatory process that decreases ligand-receptor interactions. Reduction in receptor binding after ligand exposure can result from the internalization of ligand-receptor complex, an increase in receptor degradation, and/or a decrease in gene expression resulting in a decrease in receptor biosynthesis.\nConcepts: receptor downregulation (Receptor Desensitization)\tarchitecture (Arts)\tnegative regulation of protein deubiquitination (Molecular Function)\tvitamin B12 metabolism (tetrapyrrole metabolic process)\tAnterior cerebral artery (Subdivision of cavernous part of internal carotid artery)", + "output": "receptor downregulation (Receptor Desensitization)" + }, + { + "input": "Definition: something described as an immunohistochemical technique used to detect the presence of the B220 isoform of the receptor-type tyrosine-protein phosphatase C in a tissue sample.\nConcepts: I have difficulty eating rich or \"heavy\" foods (Intellectual Product)\tEWS-ZSG Fusion Gene Long B Isoform (Gene or Genome)\tAllopathic & Osteopathic Physicians; Obstetrics & Gynecology (Physicians; Physician/Osteopath)\tReceptor-Type Tyrosine-Protein Phosphatase C Isoform B220 Staining Method (Immunohistochemistry)\tMenstruation disorders (Menstruation Disturbances)", + "output": "Receptor-Type Tyrosine-Protein Phosphatase C Isoform B220 Staining Method (Immunohistochemistry)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare, autosomal recessive inherited syndrome caused by mutations in the MMP2 gene. It is characterized by the presence of multiple, painless subcutaneous nodules, osteolysis particularly in the hands and feet, osteoporosis, and arthropathy.\nConcepts: NODULOSIS-ARTHROPATHY-OSTEOLYSIS SYNDROME (Rare Non-Neoplastic Disorder)\tTC21 (RRAS2 gene)\tdown regulation of telomere maintenance (regulation of telomere maintenance)\tD-Glyceric Aciduria (Rare Non-Neoplastic Disorder)\tDiffuse alveolar hemorrhage (Disease or Syndrome)", + "output": "NODULOSIS-ARTHROPATHY-OSTEOLYSIS SYNDROME (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: nucleoside monophosphate kinase activity described as catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP.\nConcepts: Mortality Map (Cancer Surveillance Project)\tNucleic Acid Core Facility (Health Care Related Organization)\turidylate kinase activity (nucleoside monophosphate kinase activity)\tSTEFIN B (Gene or Genome)\tMaximal exertion (Clinical or Research Assessment Answer)", + "output": "uridylate kinase activity (nucleoside monophosphate kinase activity)" + }, + { + "input": "Definition: Genetic Function described as any process that modulates the frequency, rate or extent of transcription factor catabolic process.\nConcepts: Caring for body parts (Daily or Recreational Activity)\tregulation of proteasome-mediated transcription factor catabolism (regulation of proteasomal ubiquitin-dependent protein catabolic process)\tGenital Examination - External Genitalia (Diagnostic Procedure)\tup-regulation of sphingolipid signaling pathway (Molecular Function)\tcolloid (Dosage Forms)", + "output": "regulation of proteasome-mediated transcription factor catabolism (regulation of proteasomal ubiquitin-dependent protein catabolic process)" + }, + { + "input": "Definition: something described as a question about whether an individual is satisfied with their current financial situation.\nConcepts: DAROLUTAMIDE (Androgen Antagonists)\tTesting, 2019-nCoV (Laboratory Procedure)\tI am satisfied with my current financial situation (Clinical or Research Assessment Question)\tuCalpain and friends in Cell spread (Cell Motility Pathway)\tUterine Corpus Cancer pT3 TNM Finding v6 (Uterine Corpus Cancer Pathologic Primary Tumor TNM Finding v6)", + "output": "I am satisfied with my current financial situation (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVA includes: Any T, N0, M1a, Any G. N0: No regional lymph node metastasis. M1a: Distant metastasis to lung.\nConcepts: Guernsey (Channel Islands)\tregulation of serine-type endopeptidase activity (regulation of endopeptidase activity)\tresponse to toxic substance (Cell Function)\tStage IVA Osteosarcoma AJCC v7 (Stage IVA Bone Sarcoma AJCC v7)\tnegative regulation of IL-1 production (Organism Function)", + "output": "Stage IVA Osteosarcoma AJCC v7 (Stage IVA Bone Sarcoma AJCC v7)" + }, + { + "input": "Definition: Congenital anemia described as a chromosomal instability syndrome that is the most common form of inherited aplastic anemia. It is inherited as an autosomal recessive or X-linked disorder. In addition to bone marrow failure, it is associated with skeletal abnormalities and increased incidence of the development of malignancy. Multiple genes are responsible for Fanconi anemia.\nConcepts: Smoothened Homolog Gene Mutation (Gene Mutant)\tcongenital aplastic anemia (Pancytopenia)\tCSK Gene (Gene or Genome)\tregulation of centriole replication (Cell Function)\tADP/ATP Translocase 3 (Amino Acid, Peptide, or Protein)", + "output": "congenital aplastic anemia (Pancytopenia)" + }, + { + "input": "Definition: N-substituted Glycines described as aminoacid occurring as an intermediate in the metabolism of choline in the kidney and liver.\nConcepts: N Methylglycine (Amino Acids)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(2;13)(q36;q14) PAX3/FOXO1 (Indicator, Reagent, or Diagnostic Aid)\tWart(s);plantar (Infection of foot)\tPhenoxybenzaminum (Carcinogenic Aromatic Amine)\tCALIBRATOR, SURROGATE (Medical Device)", + "output": "N Methylglycine (Amino Acids)" + }, + { + "input": "Definition: something described as contrasexual pubertal development caused by medical intervention.\nConcepts: Hydroxyethyl Starches/Hetastarch (Carbohydrates)\tNeoplasm malig;rectum (Malignant neoplasm of colon and/or rectum)\tB-lymphocyte Crossmatch (Laboratory Procedure)\tIatrogenic Contrasexual Pubertal Development (Disease or Syndrome)\tTEP1 c.389G>T (PTEN gene mutation)", + "output": "Iatrogenic Contrasexual Pubertal Development (Disease or Syndrome)" + }, + { + "input": "Definition: Embryophyta described as the club-moss plant family of the order Lycopodiales, class Lycopodiopsida, division Lycopodiophyta, subkingdom TRACHEOPHYTA. The common name of clubmoss applies to several genera of this family. Despite the name this is not one of the true mosses (BRYOPSIDA ).\nConcepts: Clubmoss (Plant)\tGDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tCeftolozane (Cephalosporin product)\tfilamentous growth of a population of unicellular organisms in response to chemical stimulus (Cell Function)\tPODCI145 (PODCI Pediatric Parent-Reported Version Questionnaire Question)", + "output": "Clubmoss (Plant)" + }, + { + "input": "Definition: something described as catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 3-methylcytosine.\nConcepts: RCPCIFPW (Quantitative Concept)\tCDISC SDTM Viral Resistance Findings Test Name Terminology (Unused Subset Concept)\tpreproparathyroid hormone (Peptide Hormone Gene)\tLip and Oral Cavity Carcinoma by AJCC v8 Stage (Lip and Oral Cavity Carcinoma)\ttRNA (cytosine-3-)-methyltransferase activity (tRNA (cytosine) methyltransferase activity)", + "output": "tRNA (cytosine-3-)-methyltransferase activity (tRNA (cytosine) methyltransferase activity)" + }, + { + "input": "Definition: Intellectual Product described as treatment Satisfaction Questionnaire for Medication - How satisfied or dissatisfied are you with the amount of time it takes the medication to start working?\nConcepts: Carriers, Cleaning (Medical Device)\tCLANFENUR (Pharmacologic Substance)\tTSQM0103 (Intellectual Product)\tDowngaze palsy (Disease or Syndrome)\tDRRI-2 - B: Played Important Role in Family (Intellectual Product)", + "output": "TSQM0103 (Intellectual Product)" + }, + { + "input": "Definition: Structured Product Labeling Flavor described as a characteristic of a medicinal product, specifying that its most predominant agreeable savor detected by the unified sensation of taste and olfactory receptors resembles raisin.\nConcepts: Humerus, NOS (Skeleton of free upper limb)\tWord Recall: Word [9] (Intellectual Product)\tRAISIN (Food)\tSUCCINATE SEMIALDEHYDE DEHYDROGENASE NADP (Oxidoreductase)\tinhibition of penicillin formation (negative regulation of penicillin metabolic process)", + "output": "RAISIN (Food)" + }, + { + "input": "Definition: Transport Protein Gene described as this gene is involved in protein glycosylation and magnesium ion transport.\nConcepts: InterventionalStudyProtocolVersion.interventionDescription (Conceptual Entity)\toligosaccharyltransferase 3 homolog B (Gene or Genome)\tmiRNA199A2 (Gene or Genome)\tTyphoid fever (Typhoid Fever)\tregulation of cyanophore differentiation (Cell Function)", + "output": "oligosaccharyltransferase 3 homolog B (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as data collected in the course of a clinical trial or documentation related to the integrity or administration of that data. A superset of clinical trial data.\nConcepts: Progressive Heterotopic Heteroplasia (Osteogenesis)\tBone Fibrous Dysplasias (Osteochondrodysplasias)\tClinical Trial Information (Intellectual Product)\tN-(2,6-Dioxo-3-piperidyl)phthalimide (Sedatives)\tdorsal interneuron axon guidance (Cell Function)", + "output": "Clinical Trial Information (Intellectual Product)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: O2 + a lipid linoleoyl group + a reduced electron acceptor <=> 2 H2O + a lipid alpha-linolenoyl group + an oxidized electron acceptor.\nConcepts: linolenate Delta15 desaturase activity (Molecular Function)\tPresacral nerve (Autonomic plexus)\tspatial orientation (Mental Process)\tGerm cell cancer, NOS (Germ cell tumor)\torlandin catabolism (orlandin metabolic process)", + "output": "linolenate Delta15 desaturase activity (Molecular Function)" + }, + { + "input": "Definition: Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder described as a variant of lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma.\nConcepts: Left Bundle Branch of His (Body Part, Organ, or Organ Component)\tOABQ01TC (CDISC Questionnaire Terminology)\tENV gene (Viral Envelope Gene)\tType C LyP (Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder)\tlimb regeneration (Natural regeneration)", + "output": "Type C LyP (Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder)" + }, + { + "input": "Definition: Organism Function described as the balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.\nConcepts: immature animal (animal age group)\tosmoregulation (Osmoregulation)\tLasers in surgery (Laser Therapy)\tAutosomal Recessive Disorder (Disease or Syndrome)\tRSSS01-Count on to Listen to You (RAND Social Support Survey Questionnaire Question)", + "output": "osmoregulation (Osmoregulation)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a calcium-activated enzyme that catalyzes the hydrolysis of ATP to yield AMP and orthophosphate. It can also act on ADP and other nucleoside triphosphates and diphosphates. EC 3.6.1.5.\nConcepts: Diphosphohydrolase, ATP (Hydrolase)\tStage IVC Oral Cavity Cancer AJCC v6 and v7 (Neoplastic Process)\tLaboratory incubator carbon dioxide analyzer (Monitors, Laboratory)\tSUBSTANCE, BLOOD GROUPING OF NON-HUMAN ORIGIN FOR IN VITRO DIAGNOSTIC USE (Medical Device)\tAdditional Sex Combs Like 1, Transcriptional Regulator 1 Gene Mutation (Gene Mutant)", + "output": "Diphosphohydrolase, ATP (Hydrolase)" + }, + { + "input": "Definition: something described as deficiency or dysfunction of the melanocortin 4 receptor, associated with loss-of-function mutation(s) in the MCR4 gene.\nConcepts: short; limbs (Limb structure)\tObstetrical forceps (Forceps)\tLymphovenous bypass (Operation on lymphatic structure)\tFAC06203 (FACT-BRM Version 4 Questionnaire Question)\tMC4R DEFICIENCY (Melanocortin Pathway Defect)", + "output": "MC4R DEFICIENCY (Melanocortin Pathway Defect)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of cisplatin, bleomycin and vindesine that may be used in the treatment of non-small cell lung cancer.\nConcepts: Pinna (Body part)\tMaterial or Material Leachate Pyrogenic Problem (Finding)\tlaurus (Plant)\tBleomycin/Cisplatin/Vindesine (Regimen Used to Treat Non-Small Cell Lung Carcinoma)\tClimacteric arthritis, site unspecified (Arthropathies NEC)", + "output": "Bleomycin/Cisplatin/Vindesine (Regimen Used to Treat Non-Small Cell Lung Carcinoma)" + }, + { + "input": "Definition: something described as formation of hardened covering (a scab) at a wound site. The scab has multiple functions including limiting blood loss, providing structural stability to the wound and guarding against infection.\nConcepts: lux unit (Quantitative Concept)\tIVD Test Reagent/Kits, Serology, Parasite, Leishmania Species, IgM Antibody (Medical Device)\tHistone Cluster 1 H2B Family Member N Gene (Gene or Genome)\tmetalloproteins (Amino Acid, Peptide, or Protein)\tscab formation (multicellular organismal process)", + "output": "scab formation (multicellular organismal process)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as the effect that a cardiac rhythm device malfunction had on the ability to stimulate the heart.\nConcepts: acetylsalicylic acid/simvastatin/atenolol/ramipril/thiazide capsule (Clinical Drug)\tIVD Test Reagent/Kits, Hematology, Coagulation Factor Antibody, Factor VIII (Medical Device)\tChlamydiaceae Rake 1957 (Approved Lists 1980) emend. Everett et al. 1999 (Bacterium)\tCardiac Rhythm Device Failure Manifestation (Intellectual Product)\tpositive regulation of phosphate membrane transport (positive regulation of inorganic anion transmembrane transport)", + "output": "Cardiac Rhythm Device Failure Manifestation (Intellectual Product)" + }, + { + "input": "Definition: Biological Response Modifiers described as a type of antibody that can bind to two different antigens at the same time. Bispecific antibodies are being studied in the imaging and treatment of cancer. They are made in the laboratory.\nConcepts: Bispecific Antibody (Immunologic Factor)\tClostridium licheniforme (Bacillus subtilis group)\tpoultices (Topical Preparation)\tAbnormal morphology of the palpebral fissure (Anatomical Abnormality)\thip socket (Hip Joint Implantable Prostheses)", + "output": "Bispecific Antibody (Immunologic Factor)" + }, + { + "input": "Definition: Vulvar Cancer by AJCC v7 Stage described as stage I includes: T1, N0, M0. T1: Invasive vulvar cancer confined to the vulva or perineum. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: ENTEROBACTER CLOACAE COMPLEX (Enterobacter)\taesthetics (Thesaurus of Psychological Index Terms)\tPapio papio sensu Groves (Papio)\tRNA-dependent DNA polymerase activity (Genetic Function)\tStage I Vulvar Cancer (Vulvar Cancer by AJCC v7 Stage)", + "output": "Stage I Vulvar Cancer (Vulvar Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: something described as a score of 2 on the COXEN Sensitivity Scale.\nConcepts: hrp (MISCELLANEOUS PLANT PRODUCTS)\tHAMD313 (HAMD 24 Clinical Classification Question)\tSCHWANNOMA, INTRAMURAL, MALIGNANT (Experimental Organism Neoplasm)\tS-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity (rRNA (adenine) methyltransferase activity)\tCOXEN Score 2 (COXEN Sensitivity Scale)", + "output": "COXEN Score 2 (COXEN Sensitivity Scale)" + }, + { + "input": "Definition: Syphilis described as subacute to chronic infectious venereal disease caused by the spirochete treponema pallidum.\nConcepts: positive regulation of pulmonary blood pressure (Organism Function)\tBicycling 2 Miles Nonstop (Intellectual Product)\tLEC01-Serious Accident: Learned (Intellectual Product)\tDietary fibre (Nutrients)\tTreponema pallidum; infection (Male Reproductive System)", + "output": "Treponema pallidum; infection (Male Reproductive System)" + }, + { + "input": "Definition: Nervous system structure described as the space between the end of a nerve cell and another cell. Nerve impulses are usually carried to the neighboring cell by chemicals called neurotransmitters, which are released by the nerve cell and are taken up by another cell on the other side of the synapse. The neighboring cell may be another nerve cell, a muscle cell, or a gland cell.\nConcepts: synaptic junction (Body Space or Junction)\tDIAG (Thesaurus of Psychological Index Terms)\tavocado (Fruit)\tpancreas; infection (Acute on chronic pancreatitis)\tPast 30 Days Smoked Any Cigarettes (Intellectual Product)", + "output": "synaptic junction (Body Space or Junction)" + }, + { + "input": "Definition: Intellectual Product described as extrapyramidal Symptom Rating Scale-Abbreviated - Dyskinesia: Trunk, neck.\nConcepts: Reaction lymphoma-like (Skin lesion)\tESRS-A - Dyskinesia: Trunk/Neck (ESRS-A Clinical Classification Question)\t/mL (Quantitative Concept)\tAd-rhENDO (Gene Therapy Agent)\tClient satisfaction: psychological care (Client satisfaction)", + "output": "ESRS-A - Dyskinesia: Trunk/Neck (ESRS-A Clinical Classification Question)" + }, + { + "input": "Definition: something described as appendiceal carcinoma with metastasis to sites other than peritoneum.\nConcepts: LMB-9 (Pseudomonas Exotoxin Immunoconjugate)\ttemperoparietal area (Body Part, Organ, or Organ Component)\tAppendiceal Carcinoma pM1c TNM Finding v8 (Appendiceal Carcinoma pM1 TNM Finding v8)\tBEBQ Retrospective Version - Baby Got Full Up Easily (Intellectual Product)\tRounded lower back (Abnormality of the lumbar spine)", + "output": "Appendiceal Carcinoma pM1c TNM Finding v8 (Appendiceal Carcinoma pM1 TNM Finding v8)" + }, + { + "input": "Definition: Disease or Syndrome described as abnormally high level of amylase in the blood.\nConcepts: neutrophil mediated immunity (Biologic Function)\tEB-305 ea 23 min (Therapeutic or Preventive Procedure)\tStage I Uterine Sarcoma AJCC v7 (Uterine Corpus Sarcoma by AJCC v7 Stage)\tElevated Amylase (Pathologic Processes)\tN-terminal protein myristoylation (Molecular Function)", + "output": "Elevated Amylase (Pathologic Processes)" + }, + { + "input": "Definition: positive regulation of response to stimulus described as any process that activates or increases the frequency, rate or extent of parkin-mediated mitophagy in response to mitochondrial depolarization.\nConcepts: Musculus longissimus thoracis (Body Part, Organ, or Organ Component)\tLEC01-Sudden Accidental Death: Learned (LEC-5 Standard Version Questionnaire Question)\tIntraperitoneal Solution Dose Form (Solution Dosage Form)\tpositive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization (regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)\tDS01TC (CDISC Clinical Classification Terminology)", + "output": "positive regulation of PRKN-mediated stimulation of mitophagy in response to mitochondrial depolarization (regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)" + }, + { + "input": "Definition: history and geography described as the branch of biology concerned with the relations between organisms and their environment.\nConcepts: URETHRAL DISORDER (Urologic Diseases)\tMolecular Probe (Diagnostic Uses of Chemicals)\tSerine Hydrolase Gene (Hydrolase Gene)\tecology (Occupation or Discipline)\tFexofenadine hydrochloride (F [Preparations])", + "output": "ecology (Occupation or Discipline)" + }, + { + "input": "Definition: regulation of cytokine biosynthetic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A.\nConcepts: Connexin beta 2 (Connexins)\tPODCI Pediatric Parent-Reported Version - Gym Limited by: Health (Intellectual Product)\tcaprolactam metabolic process (Molecular Function)\tregulation of lymphotoxin A formation (regulation of lymphotoxin A production)\tpositive regulation of HGF receptor signalling pathway (regulation of hepatocyte growth factor receptor signaling pathway)", + "output": "regulation of lymphotoxin A formation (regulation of lymphotoxin A production)" + }, + { + "input": "Definition: Cell Component described as a small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes.\nConcepts: nuclear dicing body (Cell Component)\tINSULIN (Hormone)\tBMP2B1 (BMP4 gene)\tanti-c-Met monoclonal antibody ARGX-111 (Immunologic Factor)\tPulsatillae / bai tou weng (Plant)", + "output": "nuclear dicing body (Cell Component)" + }, + { + "input": "Definition: something described as any unicellular, eukaryotic organism that can be assigned to the species Toxoplasma gondii.\nConcepts: GP180 Positive (Receptor status)\tinfant formula lysine and tryptophan-free (Modified amino acid composition infant formula)\tgondius, Toxoplasma (PROTOZOA OF UNCERTAIN TAXONOMIC POSITION)\twatery stool (Chemotherapy: Disruptive Physical Effects)\tCopanlisib Dihydrochloride (Organic Chemical)", + "output": "gondius, Toxoplasma (PROTOZOA OF UNCERTAIN TAXONOMIC POSITION)" + }, + { + "input": "Definition: something described as a developmental defect characterized by the absence of the Third ventricle.\nConcepts: regulation of SUMO conjugating enzyme activity (Molecular Function)\tAbsence of the third cerebral ventricle (Anatomical Abnormality)\tiron ion transport (transition metal ion transport)\t4q26-q32 (Chromosome band)\tendoderm formation (formation of primary germ layer)", + "output": "Absence of the third cerebral ventricle (Anatomical Abnormality)" + }, + { + "input": "Definition: Digestive System Part described as proximal part of the intestine, extending from the pylorus to the cecum; about twenty feet long in humans.\nConcepts: Physical contact in relationships (Social Behavior)\tGrade 1 Activated Partial Thromboplastin Time Prolonged, CTCAE (Activated Partial Thromboplastin Time Prolonged, CTCAE)\tSoft Tissue Sarcoma of the Trunk and Extremities Clinical Distant Metastasis TNM Finding v8 (Soft Tissue Sarcoma of the Trunk and Extremities Clinical TNM Finding v8)\tGastrointestinal Tract, Small Intestine (Intestines)\tConsciousness neurological status (Neurocognitive)", + "output": "Gastrointestinal Tract, Small Intestine (Intestines)" + }, + { + "input": "Definition: Nutritionally variant streptococci described as any bacteria that is not assigned to the species level but can be assigned to the Granulicatella genus level.\nConcepts: GRANULICATELLA (Bacterium)\tSterilizer (Electromechanical Devices)\tLIGHT, SURGICAL, FLOOR STANDING (Medical Device)\tregulation of juvenile hormone secretion (regulation of hormone secretion)\t3-methylbutanal reductase (NADP) activity (alcohol dehydrogenase (NADP+) activity)", + "output": "GRANULICATELLA (Bacterium)" + }, + { + "input": "Definition: Glycyrrhiza described as licorice.\nConcepts: I-TAC (Laboratory Procedure)\tMRKH anomaly (Syndrome)\tGlycyrrhiza glabra / licorice (Plant)\tArthrobacter (Bacterium)\tTHORACOPLASTY (Therapeutic or Preventive Procedure)", + "output": "Glycyrrhiza glabra / licorice (Plant)" + }, + { + "input": "Definition: something described as a measurement of the gonadotropin releasing hormone in a biological specimen.\nConcepts: Dystrophy, Oculopharyngeal Muscular (Digestive system hereditary disorder)\tInterceptive Treatment (Orthodontic procedure)\tBekanamycin (Antibiotic)\tGrade 1 Flu Like Symptoms, CTCAE (Flu Like Symptoms, CTCAE)\tGNRH (Hormone measurement)", + "output": "GNRH (Hormone measurement)" + }, + { + "input": "Definition: GTPase binding described as stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.\nConcepts: Benzeneethanamine, Alpha-Methyl-, (S)-, Sulfate (D [Preparations])\tguanyl-nucleotide releasing factor (molecular function regulator)\tdrug-induced thrombocytopenia (Acquired thrombocytopenia)\tdorsal tenia tecta (tenia tecta)\tregulation of ductus arteriosus closure (Organ or Tissue Function)", + "output": "guanyl-nucleotide releasing factor (molecular function regulator)" + }, + { + "input": "Definition: something described as one of two or three parts of the medial preoptic nucleus in the macaque ( Paxinos-2009a ) the rat ( Swanson-2004 ) and the mouse ( Dong-2004 ). All three species have a lateral part of the medial preoptic nucleus. The rat and the mouse have in addition a central part of the medial preoptic nucleus. Functionally the medial preoptic nucleus is part of the behavior control column of the subcortical motor system ( Swanson-2004 ).\nConcepts: spinocerebellar ataxia 7 (Ataxia, Spinocerebellar)\tmedial part of the medial preoptic nucleus (Body Part, Organ, or Organ Component)\tCCQ0107 (CCQ 24 Hour Version Questionnaire Question)\tB-Cell Stimulatory Factor-1 (Interleukins)\tyolk formation (cellular process involved in reproduction in multicellular organism)", + "output": "medial part of the medial preoptic nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as emotion characterized by feelings of tension, worried thoughts, and inadequacy in a social setting.\nConcepts: Social Anxiety (Psychological Disorders)\tregulation of kinase activity (regulation of transferase activity)\tMid anteroseptal zone of myocardium of left ventricle (Myocardium of region of mid zone of left ventricle)\tComponent or Accessory Incompatibility (Finding)\tMucinous colorectal carcinoma (Neoplastic Process)", + "output": "Social Anxiety (Psychological Disorders)" + }, + { + "input": "Definition: Food described as foods prepared by the client or supportive individuals.\nConcepts: Dihydroxypregnadienes (Organic Chemical)\tHigh calcium diet (High mineral diet)\tChromogenic Assay (Assay)\tSelf prepared food (Food)\tBR-body (cytoplasmic ribonucleoprotein granule)", + "output": "Self prepared food (Food)" + }, + { + "input": "Definition: Pharmacologic Substance described as a proprietary, albumin-binding platinum (Pt)-based complex containing a prodrug form of the platinum compound cisplatin and a maleimide moiety, with an ability to strongly and selectively bind human serum albumin (HSA), and with potential antineoplastic activity. Upon intravenous administration, the maleimide group of BTP-114 rapidly conjugates with HSA in the bloodstream; this prolongs the blood circulation, enhances the half-life, and alters the biodistribution of BTP-114, as compared to cisplatin alone. Thus, BTP-114 demonstrates enhanced extravasation to the tumor, an increased accumulation in the tumor tissue and enhanced uptake by cancer cells. The prodrug form is reduced in the hypoxic tumor cell environment, which releases the highly cytotoxic active metabolite cisplatin. Once inside the tumor cell, cisplatin binds to nucleophilic groups, such as GC-rich sites, in DNA and induces intrastrand and interstrand DNA cross-links, resulting in apoptosis and cell growth inhibition. Compared to cisplatin alone, BTP-114 has improved selectivity towards tumor tissue, thereby enhancing efficacy while reducing systemic toxicities.\nConcepts: Albumin-conjugating Platinum-prodrug BTP-114 (Pharmacologic Substance)\tHOLDER, HEAD, NEUROSURGICAL (holder)\tTFDP2 gene (Transcription factor genes)\tPseudostratified Columnar Epithelium (Simple columnar epithelium)\tArea 30 of Mauss (Body Part, Organ, or Organ Component)", + "output": "Albumin-conjugating Platinum-prodrug BTP-114 (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene may be involved in transcriptional regulation.\nConcepts: downregulation of apoptosis (regulation of apoptotic process)\tADL03-Total ADCS-ADL Score (ADCS-ADL MCI Questionnaire Question)\tHOX11L2 (Genes, Homeobox)\tMuscular ventricular septum defect (Congenital anomaly of cardiovascular system)\tmorphogenesis of embryonic epithelium (Organ or Tissue Function)", + "output": "HOX11L2 (Genes, Homeobox)" + }, + { + "input": "Definition: something described as diabetes Distress Scale for Adults with Type 1 Diabetes (T1-DDS) Subscale 2 - Management distress.\nConcepts: Ambulation assistance (Physiotherapy/remedial therapy)\tEctrodactyly polydactyly syndrome (Autosomal recessive hereditary disorder)\tGOSE1-Extent of Disruption (GOSE Questionnaire Question)\tMEDI9447 (Amino Acid, Peptide, or Protein)\tDDS01-Subscale 2: Management Distress (Intellectual Product)", + "output": "DDS01-Subscale 2: Management Distress (Intellectual Product)" + }, + { + "input": "Definition: something described as using a device to apply force to a client's osseous and/or adjacent soft tissue structures of each rib facet to restore his or her normal anatomical and/or physiological structure and/or function. Service is billed per adjustment(s).\nConcepts: Perinatal Terminology (NICHD Terminology)\tFungal Endophthalmitis (Fungal eye infections)\tHOMER3 (Structural gene)\tAllopathic & Osteopathic Physicians; Anesthesiology, Critical Care Medicine (Professional or Occupational Group)\tRib device adjustment each adjustment (Therapeutic or Preventive Procedure)", + "output": "Rib device adjustment each adjustment (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as diagnosis aimed at distinguishing between physical and/or mental disorders of similar character by comparison of symptoms.\nConcepts: germacrene A hydroxylase activity (Molecular Function)\tCytoband Range (Intellectual Product)\tthyroglobulin (Binding Proteins)\tEverted lips (Finding)\tDiagnosis, Differential (Diagnostic Procedure)", + "output": "Diagnosis, Differential (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as the date time of the onset of symptoms of the clinical event.\nConcepts: ECHINOCOCCUS VOGELI (Genus: Echinococcus)\tAverrhoa L., 1753 (Plant)\tOxymonads (Preaxostyla)\tSymptom Onset Date (Temporal Concept)\tNeonatal autoimmune haemolytic anaemia (Autoimmune hemolytic anemia)", + "output": "Symptom Onset Date (Temporal Concept)" + }, + { + "input": "Definition: Pharmacologic Substance described as an antibody-drug conjugate (ADC) composed of a humanized monoclonal antibody directed against the anti-solute carrier family 39 zinc transporter member 6 (SLC39A6; LIV-1; ZIP6) protein that is conjugated, via a protease-cleavable linker, to the cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration and internalization by LIV-1-positive tumor cells, anti-LIV-1 antibody-drug conjugate SGN-LIV1A undergoes enzymatic cleavage to release MMAE into the cytosol. In turn, MMAE binds to and inhibits tubulin polymerization, which may result in G2/M phase cell cycle arrest and apoptosis in LIV-1-expressing tumor cells. LIV-1, a member of the zinc transporter family, is expressed in several types of solid tumors and plays a key role in tumor cell progression and metastasis. The linkage system in SGN-LIV1A is highly stable in plasma, resulting in cytotoxic specificity against LIV-1-positive cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C112001\" active clinical trials using this agent.\nConcepts: Intestinal-Type Adenocarcinoma (Primary malignant neoplasm)\tWas another Form of Birth Control Ever Used (Intellectual Product)\tregulation of IL-19 production (Organism Function)\tSGN-LIV1A (Pharmacologic Substance)\tmalate dehydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)", + "output": "SGN-LIV1A (Pharmacologic Substance)" + }, + { + "input": "Definition: Mature T-Lymphocyte described as a subset of T-lymphocytes that express the CD8 surface glycoprotein and bind epitopes that are part of class I histocompatibility molecules. CD8-positive T-lymphocytes include cytotoxic T-lymphocytes and CD8+ suppressor T-lymphocytes.\nConcepts: 3',5'-Cyclic-AMP 5'-Nucleotidohydrolase Type 4 (Amino Acid, Peptide, or Protein)\tMacrophage Cell Biology (Cellular Immunology)\tT8 Lymphocyte (Entire cell)\tMYCOBACT PARATUBERC (Mycobacterium avium)\tTremor, volitional (Central Nervous System)", + "output": "T8 Lymphocyte (Entire cell)" + }, + { + "input": "Definition: something described as a gastrin-producing enteroendocrine cell that is located in the gastric antrum.\nConcepts: Occupational Health Nursing (Care given by nurses)\tGastrin-Secreting Cell (Cell)\tDisease coronary artery (Coronary Vessel Disorders)\tInsufficient Cooling (Temperature Problem)\tPAP (PAPOLA gene)", + "output": "Gastrin-Secreting Cell (Cell)" + }, + { + "input": "Definition: Intracellular Transport described as the directed movement of auxins within a cell. Auxins are a group of plant hormones that regulates aspects of plant growth.\nConcepts: PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Legs Hurt (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)\tintracellular auxin transport (auxin influx)\tSeneca Valley Virus-001 (Virus)\tAbnormal mitochondria in muscle (Anatomical Abnormality)\tMER (MERTK gene)", + "output": "intracellular auxin transport (auxin influx)" + }, + { + "input": "Definition: something described as single Nucleotide Polymorphism in Regulatory Sequences (Regulatory Region SNP) consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a gene region that is involved in the regulation of genetic processes, such as transcription and replication.\nConcepts: rSNP (Nucleotide Sequence)\tCDISC ADAS-Cog - Delayed Word Recall: Word 4 (Intellectual Product)\tMethylbenzene (Cycloalkenes)\tReported By (Group)\tUndifferentiated Pleomorphic Sarcoma (Histiocytoma)", + "output": "rSNP (Nucleotide Sequence)" + }, + { + "input": "Definition: Professional or Occupational Group described as electrodiagnostic medicine is the medical subspecialty that applies neurophysiologic techniques to diagnose, evaluate, and treat patients with impairments of the neurologic, neuromuscular, and/or muscular systems. Qualified physicians are trained in performing electrophysiological testing and interpretation of the test data. They require knowledge in anatomy, physiology, kinesiology, histology, and pathology of the brain, spinal cord, autonomic nerves, cranial nerves, peripheral nerves, neuromuscular junction, and muscles. They must know clinical features and treatment of diseases of the central, peripheral, and autonomic nervous systems, as well as those of neuromuscular junction and muscle. Physicians also require special knowledge about electric signal processing, including waveform analysis, electronics and instrumentation, stimulation and recording equipment, and statistics.\nConcepts: Allopathic & Osteopathic Physicians; Electrodiagnostic Medicine (Professional or Occupational Group)\tBelize (Geographic Area)\tFDPL5PS (Classification)\tHydrolysis (Chemical Processes)\tSpecialism (Idea or Concept)", + "output": "Allopathic & Osteopathic Physicians; Electrodiagnostic Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Research Activity described as general research on hematopoietic stem cells and research on their use in medicine.\nConcepts: Infection, Spirochaetales (Spirochaetales Infections)\tCalcified amorphous tumour of the heart (Neoplastic Process)\tIFN-gamma Receptor 1 Deficiency (Immunologic Deficiency Syndromes)\tHematopoietic Stem Cell Research (Research Activity)\tAuditory receptor (Teloreceptor)", + "output": "Hematopoietic Stem Cell Research (Research Activity)" + }, + { + "input": "Definition: Abdominal visceral abscess described as a circumscribed area of pus or necrotic debris in the parenchyma of the pancreas. []\nConcepts: BDVI, Rat Strain (Mammal)\tUnit of magnetic flux (Unit of Electricity and Magnetism)\tPANCREAS, ABSCESS (Disease or Syndrome)\tCART-EGFR TCR zeta:CD1 27 cells (Cell)\tPivampicillin Hydrochloride (Antibiotic)", + "output": "PANCREAS, ABSCESS (Disease or Syndrome)" + }, + { + "input": "Definition: RNA Helicase described as a component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of MRNA. The unwinding facilitates the binding of the 40S ribosomal subunit.\nConcepts: Hokkaido (Non-Sporting Breed)\tEIF 04A (Biologically Active Substance)\tdisaccharide metabolic process (Molecular Function)\tregulation of hydroxymethylglutaryl-CoA reductase (NADPH) activity (regulation of oxidoreductase activity)\tDOUBLECORTIN (Cytoskeletal Gene)", + "output": "EIF 04A (Biologically Active Substance)" + }, + { + "input": "Definition: HYOU1 gene described as human HYOU1 wild-type allele is located within 11q23.1-q23.3 and is approximately 13 kb in length. This allele, which encodes hypoxia up-regulated protein 1, is involved in the cytoprotective response to hypoxia-induced cellular perturbation.\nConcepts: Grp170 (HYOU1 gene)\tderived variable (Intellectual Product)\tREAGENTS, CYSTICERCOSIS (Indicator, Reagent, or Diagnostic Aid)\tTranscription Factor AP-4 (Activating Enhancer Binding Protein 4) wt Allele (TFAP4 gene)\tPassword (Intellectual Product)", + "output": "Grp170 (HYOU1 gene)" + }, + { + "input": "Definition: Vrozen\u00e9 poruchy metabolismu NEC in MDRCZE23 0 described as a constellation of disorders whose common thread is the insufficient quantity of one or more mitochondrial enzymes.\nConcepts: 5 alpha Reductase (Amino Acid, Peptide, or Protein)\tMitochondrial enzyme deficiency (Disease or Syndrome)\tDeleterious RAD50 Double Strand Break Repair Protein Gene Mutation (Cell or Molecular Dysfunction)\tSystems (LOINC Axis)\tElectrophysiology (Diagnostic Procedure)", + "output": "Mitochondrial enzyme deficiency (Disease or Syndrome)" + }, + { + "input": "Definition: Pharmacologic Substance described as acetate of potash.\nConcepts: Hemoglobin Subunit Beta Protein Variant (Cell or Molecular Dysfunction)\tkali aceticum/potasssium ace (Pharmacologic Substance)\tTibial metaphyseal irregularity (Lower-limb metaphyseal irregularity)\tCDK2/4/6/FLT3 inhibitor FN-1501 (Pharmacologic Substance)\tbeta-amyloid formation (Molecular Function)", + "output": "kali aceticum/potasssium ace (Pharmacologic Substance)" + }, + { + "input": "Definition: cGMP Phosphodiesterase Inhibitor described as a benzenesulfonamide derivative with vasodilatory activity. Udenafil selectively inhibits phosphodiesterase type 5 (PDE5), thus inhibiting the degradation of cyclic guanosine monophosphate (cGMP) found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis; inhibition of cGMP degradation results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, and, so, prolonged penile erection. This agent does not significantly inhibit the PDE11 isozyme; PDE11 inhibition may be associated with significant myalgia.\nConcepts: principal part of the gracile nucleus (Structure of nucleus gracilis)\tHuman leucocyte antigen B40 (HLA-B Antigens)\tQK (Gene or Genome)\tSpecial Exceptions Process (Funding)\t3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-{2-[(2RS)-1-methylpyrrolidin-2-yl]ethyl}-4-propoxybenzenesulfonamide (cGMP Phosphodiesterase Inhibitor)", + "output": "3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-{2-[(2RS)-1-methylpyrrolidin-2-yl]ethyl}-4-propoxybenzenesulfonamide (cGMP Phosphodiesterase Inhibitor)" + }, + { + "input": "Definition: statistical effects and errors described as the ability of a statistic to reject a false hypothesis.\nConcepts: fatiguing (Finding reported by subject or history provider)\tphospholipid (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)\tIVD Test Reagent/Kits, Immunoassay, Rapid Test, Fertility, Follicle Stimulating Hormone (Medical Device)\tstatistical power (Statistical Technique)\tcresyl violet acetate (Organic Chemical)", + "output": "statistical power (Statistical Technique)" + }, + { + "input": "Definition: Upper gastrointestinal procedure described as endoscopic examination of the stomach.\nConcepts: Cleomes (Capparaceae)\tBD (Research or Clinical Assessment Tool)\tAmmonium Hydroxide (Hydroxides)\tfiberoptic examinations gastroscopy (Endoscopy of stomach)\tSalivary Gland Sclerosing Polycystic Adenosis (Neoplastic Process)", + "output": "fiberoptic examinations gastroscopy (Endoscopy of stomach)" + }, + { + "input": "Definition: something described as serology reagents intended to detect immunoglobulin G (IgG) antibodies to Haemophilus influenzae, a bacterium of the family Pasteurellaceae. These bacteria induce an inflammatory response that causes diseases. Encapsulated (polysaccharide) organisms of Haemophilus influenzae type B cause bacteremia and acute bacterial meningitis; they may occasionally cause other diseases (e.g., obstructive laryngitis, cellulitis, osteomyelitis, bacterial pneumonia).\nConcepts: Facial dermoid cyst (Neoplastic Process)\tAlmost Constantly (Finding)\tIVD Test Reagent/Kits, Serology, Bacteria, Haemophilus influenzae, IgG Antibody (IVD Test Reagent/Kits, Serology, Bacteria)\tGordonia rubripertincta (Actinomyces)\tC. diff. Positive (Laboratory or Test Result)", + "output": "IVD Test Reagent/Kits, Serology, Bacteria, Haemophilus influenzae, IgG Antibody (IVD Test Reagent/Kits, Serology, Bacteria)" + }, + { + "input": "Definition: something described as a subjective score of 8 on a difficulty falling asleep scale that ranges from 0: No difficulty to 10: Didn't fall asleep.\nConcepts: MPEG1 protein, human (Amino Acid, Peptide, or Protein)\tslime layer organisation (Cell Function)\tBlasts Under 15 Percent of Peripheral Blood White Cells (Finding)\tPyrene (Organic Chemical)\tDifficulty Falling Asleep Score 8 (Difficulty Falling Asleep Scale)", + "output": "Difficulty Falling Asleep Score 8 (Difficulty Falling Asleep Scale)" + }, + { + "input": "Definition: something described as tumor lysis syndrome (TLS): caused by release of tumor cell contents either from spontaneous cell lysis or in response to therapy. Characteristic findings: hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia. Can lead to downstream effects: renal insufficiency, cardiac arrhythmia, seizures , death (due to multiorgan failure). Dying cells release cytokines which may cause a systemic inflammatory response syndrome and multiorgan failure. Occurs most frequently in patients with high grade non-Hodgkin lymphoma and acute leukemia. Other tumors can also be implicated. Patients at highest risk having pre-existing: chronic renal insufficiency, oliguria, dehydration, hypotension, acidic urine. Management directed toward, metabolic and renal complications through supportive care. Distinction between \"laboratory\" TLS and \"clinical\" TLS: \"laboratory\" TLS requires two or more of the following abnormalities within 3 days before and 7 days after starting therapy: hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia; \"clinical\" TLS occurs when \"laboratory\" TLS has been established and is also accompanied by: increased creatinine level, seizures, cardiac dysrhythmia, or death. Renal injury is an important aspect of the disorder; occurs when calcium phosphate, xanthine and uric acid precipitate in renal tubules leading to obstruction and inflammation.\nConcepts: ca15 3 (Antigens, Tumor-Associated, Carbohydrate)\tTumor lysis syndrome (Classification)\tP-Selectin Measurement (Laboratory Procedure)\tSymptom Interference Score 8 (Finding)\tsomatic (Qualitative Concept)", + "output": "Tumor lysis syndrome (Classification)" + }, + { + "input": "Definition: regulation of protein desumoylation described as any process that decreases the frequency, rate or extent of protein desumoylation. Protein desumoylation is the process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein.\nConcepts: negative regulation of cellular organohalogen metabolic process (regulation of cellular organohalogen metabolic process)\tHICS complex location (protein-containing complex)\tnegative regulation of protein desumoylation (negative regulation of protein modification by small protein conjugation or removal)\tPhysicians - Family Practice - Geriatric Medicine (Professional or Occupational Group)\tSIRTs (Enzyme)", + "output": "negative regulation of protein desumoylation (negative regulation of protein modification by small protein conjugation or removal)" + }, + { + "input": "Definition: Aplasia/Hypoplasia of the radius described as missing radius bone associated with congenital failure of development.\nConcepts: Investigational Treatment (Therapeutic or Preventive Procedure)\thomeobox A3 (Gene or Genome)\tBahamas (Caribbean country)\tPARPi (Indicator, Reagent, or Diagnostic Aid)\tMissing outer large bone of forearm (Absent forearm bone)", + "output": "Missing outer large bone of forearm (Absent forearm bone)" + }, + { + "input": "Definition: Cell Function described as the localization process by which an autophagic substrate is delivered to a forming autophagosome.\nConcepts: substrate sequestration to autophagosome (establishment of localization in cell)\tFallopian Tube Serous Tumor (Neoplastic Process)\tUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity (Molecular Function)\tTripotassium dicitratobismuthate-containing product (Bismuth preparation)\tShigellosis, unspecified (Dysentery, Bacillary)", + "output": "substrate sequestration to autophagosome (establishment of localization in cell)" + }, + { + "input": "Definition: Hereditary progressive muscular dystrophy described as a progressive disorder involving pelvic and scapular girdle muscles marked by weakness of proximal muscles of hip and shoulder areas with variable psychiatric disorders and occasional mild mental retardation. Type IA (LGMD1A) Synonym: proximal limb-girdle muscular dystrophy type 1A A slowly progressive form of muscular dystrophy affecting the proximal limb muscles but sparing the face. (159000) Type IB (LGMD1B) Synonym: proximal limb-girdle muscular dystrophy type 1B A slowly progressive form of muscular dystrophy differing from LGMD1A by the nasal quality of speech. (OMIM 159001) Type 2 (LGMD2, LGMD2A) Synonyms: Leyden-Mobius syndrome distal muscular dystrophy pelvofemoral muscular dystrophy pelvofemoral syndrome tibial muscular dystrophy Muscular dystrophy involving first the pelvic or, less commonly, shoulder girdle with occasional pseudohypertrophy of the calves with onset usually in childhood but sometimes in later stages of life. Muscle wasting tends to be asymmetric when the upper limbs are first involved. Progression of disease varies with inability to walk usually taking place at about 20 to 30 years of onset. Facial weakness and contractures may occur later. (OMIM 253600) Type 3 (LGMD3, LGMD2B) A slowly progressive form of muscular dystrophy involving the pelvic girdle with onset in the late teens.\nConcepts: Limb Girdle Muscular Dystrophies (Muscular Dystrophy)\tbacterial arthritis (Disease or Syndrome)\tVFQ1-Rate Your Overall Health (VFQ25-Interviewer Administered Format Questionnaire Question)\tBenchmark (Quantitative Concept)\tColonic Crohn's disease (Colitis)", + "output": "Limb Girdle Muscular Dystrophies (Muscular Dystrophy)" + }, + { + "input": "Definition: Ataxias, Hereditary described as a rare genetic multiple congenital anomalies/dysmorphic syndrome with characteristics of cerebellar-like ataxia, photosensitivity (mainly of the face and trunk), short stature and intellectual disability. Additional features include clinodactyly, single palmar transverse crease, high-arched palate, pseudohypertrophy of the calves and aortic valve lesions. There have been no further descriptions in the literature since 1983.\nConcepts: PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Hard for Family to Rest (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tFenton Wilkinson Toselano syndrome (Multiple system malformation syndrome)\tserotonin-activated cation-selective channel activity (transmitter-gated ion channel activity)\tBcl-2 Homology Domain (Amino Acid Sequence)\tGovernmentFunding.serialNumberText (Serial Number)", + "output": "Fenton Wilkinson Toselano syndrome (Multiple system malformation syndrome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as also a name for EC 1.13.11.11, TRYPTOPHAN 2,3 DIOXYGENASE, do not confuse.\nConcepts: Coccidioides IgM Antibody Measurement (Laboratory Procedure)\tTDO (Carbon-Carbon Lyases)\tNitro Compounds (Organic Chemical)\tEMO103 (ERT Functional Test Question)\t6-N-(1-hydroxymethyl-2-hydroxy)ethylamino-12,13-dihydro-2,10-dihydroxy-13-glucopyranosyl-5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)dione (Pharmacologic Substance)", + "output": "TDO (Carbon-Carbon Lyases)" + }, + { + "input": "Definition: Intellectual Product described as a question whether paraneoplastic syndrome is present.\nConcepts: CD31 (Gene or Genome)\tStaphylococcus schleiferi subsp. coagulans (Staphylococcus, coagulase positive)\tIs Paraneoplastic Syndrome Present (Intellectual Product)\tMouse Plasma Cell Myeloma (Neoplastic Process)\tskunk (Pinnipedia)", + "output": "Is Paraneoplastic Syndrome Present (Intellectual Product)" + }, + { + "input": "Definition: Receptors, Purinergic P1 described as a subtype of ADENOSINE RECEPTOR that is found expressed in a variety of locations including the BRAIN and endocrine tissues. The receptor is generally considered to be coupled to the GI, INHIBITORY G-PROTEIN which causes down regulation of CYCLIC AMP.\nConcepts: V/m (Quantitative Concept)\tFatty Acid 19:1 (Organic Chemical)\tAU (Affiliate Realms)\tRECEPT ADENOSINE A3 (Receptors, Purinergic P1)\tEmulsion (Liquid Dosage Form)", + "output": "RECEPT ADENOSINE A3 (Receptors, Purinergic P1)" + }, + { + "input": "Definition: something described as a simple Cycled study requiring one file to describe the conditions.\nConcepts: Cross Cultural Counseling (Health Care Activity)\tCoronavirus Group 2 (Genus: Coronavirus)\ttemporary halt (Clinical Study Status)\tCycled Drug Stability Study-Simple (Intellectual Product)\tmonoclonal gammopathy of undetermined significance IgM (Neoplastic Process)", + "output": "Cycled Drug Stability Study-Simple (Intellectual Product)" + }, + { + "input": "Definition: Complete duplication of the distal phalanges of the hand described as complete duplication of the distal phalanx of ring finger.\nConcepts: Low-cholesterol diet (Diet therapy)\tComplete duplication of the distal phalanx of the 4th finger (Duplication of the distal phalanx of the 4th finger)\tIf you answered (Form Directive)\tTRIM16 gene (Gene or Genome)\tChess-pawn distal phalanges (Foot)", + "output": "Complete duplication of the distal phalanx of the 4th finger (Duplication of the distal phalanx of the 4th finger)" + }, + { + "input": "Definition: Gene or Genome described as a fusion gene that results from a chromosomal translocation t(11;17)(q23;q12-21) which fuses the 5' half of the MLL gene to the 3' half of the LASP1 gene. This rearrangement is associated with infant acute myeloid leukemia.\nConcepts: Incompetence;mitral (Heart)\tMLL-LASP1 Fusion Gene (Gene or Genome)\tBladder Cancer pT3a TNM Finding v6 (Bladder Cancer pT3 TNM Finding v6 and v7)\tDermatitis venenata (Inflammation of specific body organs)\ttransfusion of fresh frozen plasma (Therapeutic or Preventive Procedure)", + "output": "MLL-LASP1 Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: Biologic Function described as any process that stops, prevents or reduces the frequency, rate or extent of response to propan-1-ol.\nConcepts: spectroscopy (Laboratory Procedure)\tdownregulation of response to propan-1-ol (negative regulation of response to alcohol)\tgeranylgeraniol phosphotransferase activity (Molecular Function)\tUsual Time it Takes to Fall Asleep at Night (Clinical or Research Assessment Question)\tamnion-derived cellular cytokine solution (Pharmacologic Substance)", + "output": "downregulation of response to propan-1-ol (negative regulation of response to alcohol)" + }, + { + "input": "Definition: something described as cells derived from the chicken used as a biological model for research.\nConcepts: Product containing pyrimethamine (Medicinal product categorized by disposition)\tNucleic Acid Binding (Genetic Function)\tChicken Cells (Cell)\tELISA/ACT(R) Diagnostic Lectin Test Block each test (Laboratory Procedure)\tLYMPHOID IRRAD (Therapeutic or Preventive Procedure)", + "output": "Chicken Cells (Cell)" + }, + { + "input": "Definition: Transport Protein Gene described as this gene plays a role in both nuclear transport and mitosis.\nConcepts: Mato Grosso (Geographic Area)\tCell aggregation (Cell Communication)\tTUMOR POTENTIATING REGION (Gene or Genome)\tregulation of interleukin-18 secretion (Cell Function)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Hepatitis C (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Hepatitis)", + "output": "TUMOR POTENTIATING REGION (Gene or Genome)" + }, + { + "input": "Definition: something described as one of two subdivisions of the lingual gyrus, which occur in some instances when the intralingual sulcus is present; the other is the superior lingual gyrus (human) ( Duvernoy-1992 ).\nConcepts: depurination (Genetic Function)\tinferior lingual gyrus (Body Part, Organ, or Organ Component)\tepicardium-derived cardiac vascular smooth muscle cell fate commitment (Cell Function)\tquinolinate synthetase A activity (Molecular Function)\tInflammatory Myelopathy (Inflammatory disorder of head)", + "output": "inferior lingual gyrus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as an analytical technique where mass spectrometry is coupled to mass spectrometry in order to separate, identify, and quantify substances in a sample.\nConcepts: Bladder Benign PEComa (Perivascular epithelioid tumor, benign)\tElvitegravir, Cobicistat, Emtricitabine, and Tenofovir Disoproxil Fumarate (Anti-HIV Agents, Integrase Inhibitors)\tPremarket Notification Submission (Intellectual Product)\tTandem mass spectrometry (Mass Spectrometry)\tStage IIA Squamous Cell Carcinoma of the Lung (Neoplastic Process)", + "output": "Tandem mass spectrometry (Mass Spectrometry)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate.\nConcepts: DSD - Detrusr/sphnct dyssynerg (Bladder outflow dyssynergia)\tTORG-WINCHESTER SYNDROME (Disease or Syndrome)\tHematopoietic Cell Growth Factors (Growth Factor)\tDmpG (Molecular Function)\tPI3K/mTOR/ALK-1/DNA-PK Inhibitor P7170 (Pharmacologic Substance)", + "output": "DmpG (Molecular Function)" + }, + { + "input": "Definition: something described as an abnormality in uridine diphosphate glucose-4-epimerase level, an enzyme that catalyzes the reaction: UDP-glucose = UDP-galactose. []\nConcepts: Absent radius, anogenital anomalies syndrome (Multiple malformation syndrome with limb defect as major feature)\tUNMC Eppley Cancer Center (Health Care Related Organization)\trhamnogalacturonan I side chain metabolism (rhamnogalacturonan I metabolic process)\tMICROTITRATOR, FOR CLINICAL USE (Medical Device)\tAbnormal UDP-glucose 4-epimerase level (Abnormal enzyme/coenzyme activity)", + "output": "Abnormal UDP-glucose 4-epimerase level (Abnormal enzyme/coenzyme activity)" + }, + { + "input": "Definition: Organic Chemical described as 2,4-diamino-5-methyl-6-(3,4,5-trimethoxy anilinomethyl)quinazoline; one of the most widely used cancer chemotherapeutic agents.\nConcepts: adult NHL (Lymphoma, Non-Hodgkin)\tMORPHINE SULFATE (M [Preparations])\tIVD Test Reagent/Kits, Immunoassay, Gastrointestinal Enzyme, Pepsinogen, Group II (IVD Test Reagent/Kits, Immunoassay, Gastrointestinal Enzyme, Pepsinogen)\tTrimexate (T [Preparations])\tPhosphatidylinositol-Glycan Biosynthesis Class F Protein (Amino Acid, Peptide, or Protein)", + "output": "Trimexate (T [Preparations])" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as limits access of patient information to appropriate members of healthcare team. Protects patient information by complying with HIPAA rules. Shares information using a structured process in a manner that ensures patient confidentiality.\nConcepts: BIFIDOBACTERIUM ADOLESCENTIS (Bifidobacterium)\tDioscorea villosa tuber extract (Plant Roots)\tManages patient confidentiality (Therapeutic or Preventive Procedure)\tPaper Points, Endodontic (Biomedical or Dental Material)\tANTISERA, CONTROL FOR NONTREPONEMAL TESTS (Immunologic Factor)", + "output": "Manages patient confidentiality (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: trans-aconitate = cis-aconitate.\nConcepts: Tissue Fusion Electrosurgical Units (Electrosurgical Units, Monopolar/Bipolar)\tGastric Lavages, Cold (Nonoperative alimentary tract irrigation, cleaning, and local instillation)\taconitate delta2-delta3-isomerase activity (Molecular Function)\tMicrotubule-Associated Proteins 1A/1B Light Chain 3 (Biologically Active Substance)\tLi-Fraumeni Syndrome (Neoplastic Syndromes, Hereditary)", + "output": "aconitate delta2-delta3-isomerase activity (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as catheter designed to cross and recanalise chronic total occlusions in the peripheral vasculature.\nConcepts: Peptostreptococcus prevotii (Foubert and Douglas 1948) Ezaki et al. 1983 (Peptostreptococcus)\tChronic total occlusion catheter (Peripheral vascular catheter)\tMalonyl Coenzyme A (Nucleic Acid, Nucleoside, or Nucleotide)\tSOCIAL PSYCHOL (Biomedical Occupation or Discipline)\tMarasmius (Marasmiaceae)", + "output": "Chronic total occlusion catheter (Peripheral vascular catheter)" + }, + { + "input": "Definition: C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Description of non-specific active suicidal thoughts.\nConcepts: Airway hyperresponsiveness (Abnormal breathing)\tCSS05-Non-Spec Suicid Thought, Describe (C-SSRS Already Enrolled Subjects Questionnaire Question)\tBergmeister papilla (Persistent Hyperplastic Primary Vitreous)\tGenus: Foot+mouth dis vir grp (Family Picornaviridae)\tStage IIB Gastric (Stomach) Cancer (Clinical Stage II Gastric Cancer AJCC v8)", + "output": "CSS05-Non-Spec Suicid Thought, Describe (C-SSRS Already Enrolled Subjects Questionnaire Question)" + }, + { + "input": "Definition: Cell Count described as a relative measurement (ratio or percentage) of the columnar epithelial cells to non-squamous epithelial cells in a biological specimen.\nConcepts: mauritania (Africa, Western)\tColumnar Epithelial Cells to Non-Squamous Epithelial Cells Ratio Measurement (Laboratory Procedure)\tBreast malignant tumours (Classification)\tLFA-1 Alpha (Amino Acid, Peptide, or Protein)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Valproic Acid, Free (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Valproic Acid)", + "output": "Columnar Epithelial Cells to Non-Squamous Epithelial Cells Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Hereditary nephropathy described as an extremely rare syndromic lymphedema disorder characterized by four features which begin in early childhood and are progressive; hypotrichosis, lymphedema, variable telangiectasia particularly of the palms and renal defect. There is evidence that this syndrome is caused by heterozygous mutation in the SOX18 gene on chromosome 20q13.\nConcepts: cytokinesis involved in cell cycle (Cell Function)\tmethylselenol reductase activity (oxidoreductase activity, acting on NAD(P)H)\tProstatic Urethra Cancer pT1 TNM Finding v8 (Finding)\tTwelve-Thirteen Translocation Leukemia Transcript (Non-Protein Coding) Gene (Gene or Genome)\tHLTRS (hypotrichosis, lymphedema, telangiectasia, renal defect) syndrome (Congenital vascular disorder)", + "output": "HLTRS (hypotrichosis, lymphedema, telangiectasia, renal defect) syndrome (Congenital vascular disorder)" + }, + { + "input": "Definition: Angiogenesis Inhibitors described as the succinate salt of vatalanib, an anilinophthalazine derivative, with antineoplastic activity. Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.\nConcepts: modulation of sporangium germination on or near host (modulation of development of symbiont on or near host)\ttyphasterol C-23 hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)\tchromosomes male sex (Cell Component)\tHepatic Synovial Sarcoma (Neoplastic Process)\t1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate (Pharmacologic Substance)", + "output": "1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate (Pharmacologic Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan histone deacetylase (HDAC) enzymes, with potential antineoplastic activity. Upon oral administration, CUDC-907 inhibits the activity of both PI3K class I isoforms and HDAC, thereby preventing the activation of the PI3K-AKT-mTOR signal transduction pathway that is often overactivated in many cancer cell types. This may prevent growth of PI3K and/or HDAC-expressing tumor cells. CUDC-907 shows an increased inhibition of tumor cell growth and induction of apoptosis when compared to inhibitors that target either PI3K or HDAC. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C104008\" active clinical trials using this agent.\nConcepts: XGPN -Xanthogran pyelonephritr (Nephritis)\tGrade 2 Irritability, CTCAE (Irritability, CTCAE)\tCTRIGMAB (Measurement of Chlamydia trachomatis antibody)\tCUDC-907 (Pharmacologic Substance)\tGrade 2 Pericardial Effusion, CTCAE (Pericardial Effusion, CTCAE)", + "output": "CUDC-907 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as european Quality of Life Five Dimension Three Level Scale - Indicate which statements best describe your own health state today: Pain/discomfort.\nConcepts: Fox (Family canidae)\tPhysiology, Other (Physiology)\tAMERICAN PUBLIC HEALTH ASSOC (Societies)\tEQ5D0104 (EQ-5D-3L Questionnaire Question)\tT-Cell Activation Antigen S152 (Tumor Necrosis Factor Receptor)", + "output": "EQ5D0104 (EQ-5D-3L Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as hours times grams per milliliter.\nConcepts: Enrollment Status (Clinical Study Status)\tChlorhexidine/Ethyl Alcohol Mouth Rinse (Anti-Bacterial Agents)\tHour Times Gram per Milliliter (Measurement Unit Description)\tRISK INDICATORS (Knowledge level: disease process)\t1-nitro-1,2-dihydro-1,3,5-triazine hydrolase activity (Molecular Function)", + "output": "Hour Times Gram per Milliliter (Measurement Unit Description)" + }, + { + "input": "Definition: Quantitative Concept described as the earliest outcome of the study questionnaire assessment.\nConcepts: Carcinoma, Invasive Ductal, Breast (Ductal Breast Carcinoma)\tZ line (Cell Component)\tStill Point (Diagnostic Procedure)\tStylets, Bronchial (Medical Device)\tPEORRES (Quantitative Concept)", + "output": "PEORRES (Quantitative Concept)" + }, + { + "input": "Definition: Chest Pain described as location is along an imaginary vertical line on the chest originating from the midpoint of a clavicle.\nConcepts: negative regulation of ribosomal subunit export from cell nucleus (negative regulation of RNA export from nucleus)\tCP-870,893 (Pharmacologic Substance)\tCIXUTUMUMAB (Monoclonal Antibodies)\tMidclavicular line (Finding)\tCabinets, Filing, Pedestal (Cabinets, Filing)", + "output": "Midclavicular line (Finding)" + }, + { + "input": "Definition: Neoplasm of labia majora described as a benign or malignant neoplasm that affects the Bartholin gland. Representative examples include adenoma, adenomyoma, adenocarcinoma, and squamous cell carcinoma.\nConcepts: Tumor of Bartholin's Gland (Vulvar Neoplasms)\tOmeprazole product (2-Pyridinylmethylsulfinylbenzimidazoles)\tDifficulty Moving Neck and Shoulders due to Stiffness (Findings-Based Question)\tesophageal hiatal hernia (Respiratory Diaphragm)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Your Day-to-Day Work (Intellectual Product)", + "output": "Tumor of Bartholin's Gland (Vulvar Neoplasms)" + }, + { + "input": "Definition: pre-miRNA described as MIR223 pre-miRNA is an oligonucleotide that is encoded by the human MIR223 gene and has a role in the regulation of gene expression.\nConcepts: Partial retinal artery occlusion, unspecified eye (Partial retinal artery occlusion)\tAnesthesia Unit Carbon Dioxide Absorbents (Device associated with anaesthesia systems)\tEmbryo CS16 (Embryonic Structure)\tMIR223 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)\tFAC07013 (FACIT-Fatigue 13-Item Version 4 Questionnaire Question)", + "output": "MIR223 Pre-miRNA (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Injury, Poisoning and Procedural Complications, CTCAE described as a finding of separation of the approximated margins of a surgical wound.\nConcepts: Positive Psychology (Biomedical Occupation or Discipline)\tVACUOLATION, EXTRACELLULAR (Physical shape)\tWound Dehiscence (Injury, Poisoning and Procedural Complications, CTCAE)\t7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (Drug allergens)\tFAMS - Feel Overwhelmed by My Condition (FAMS Questionnaire Question)", + "output": "Wound Dehiscence (Injury, Poisoning and Procedural Complications, CTCAE)" + }, + { + "input": "Definition: something described as emotion Recognition - Number of sadness stimuli responded to as anger.\nConcepts: EMO1-Sadness Responded as Anger (Intellectual Product)\tDistributor (Professional or Occupational Group)\tAPHTHOVIRUS (Family Picornaviridae)\tparenteral administration route (Functional Concept)\tSizers, Penile Prosthesis (Medical Device)", + "output": "EMO1-Sadness Responded as Anger (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human MAPK13 wild-type allele is located in the vicinity of 6p21.31 and is approximately 86 kb in length. This allele, which encodes mitogen-activated protein kinase 13 protein, plays a role in the regulation of protein translation and cellular signaling in response to environmental stress or pro-inflammatory cytokines.\nConcepts: PACS1 wt Allele (Gene or Genome)\tobsolete cytoskeletal anchoring activity (Molecular Function)\tExtremophiles (Organism)\tMAPK13 wt Allele (Gene or Genome)\tCortex piriformis (Body Part, Organ, or Organ Component)", + "output": "MAPK13 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: negative regulation of alpha-beta T cell proliferation described as any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation.\nConcepts: Law occupation (Education/welfare/health profession)\tvitamin C (Vitamin C [EPC])\t10^6 CFU/Milliliter (Quantitative Concept)\tauxin conjugate metabolic process (Molecular Function)\tnegative regulation of CD8-positive, alpha-beta T cell proliferation (negative regulation of CD8-positive, alpha-beta T cell activation)", + "output": "negative regulation of CD8-positive, alpha-beta T cell proliferation (negative regulation of CD8-positive, alpha-beta T cell activation)" + }, + { + "input": "Definition: WISC-V subtests described as a subtest of the Wechsler Intelligence Scale for Children, Fifth Edition. The subject scans a search group and indicates whether one of the symbols in the target group matches.\nConcepts: Transcription Initiation Factor TFIID 15 kDa Subunit (TAF12 Gene Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, BCOR (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tThymic Stromal Lymphopoietin Protein Receptor (Receptor)\tSymbol Search Subtest (WISC-V subtests)\tlactoglobulin (Amino Acid, Peptide, or Protein)", + "output": "Symbol Search Subtest (WISC-V subtests)" + }, + { + "input": "Definition: something described as tracheal stents manufactured from metallic alloys, such as stainless steel, platinum, or nickel titanium alloys (e.g., nitinol). These devices typically consist of a metallic (e.g., meshlike wire) tube, and some include a plastic cover. Tracheal metallic stents may be either balloon expandable or self-expandable. They are permanent devices typically deployed under local anesthetics using flexible bronchoscopes; they are used to treat stenosis caused by injuries, benign diseases, or malignant tumors.\nConcepts: negative regulation of translational initiation by iron (negative regulation of translational initiation)\tRecurrent Submandibular Gland Squamous Cell Carcinoma (Recurrent Head and Neck Squamous Cell Carcinoma)\tStents, Tracheal, Metallic (Medical Device)\tKi-1 Low (Laboratory or Test Result)\texploration behaviour (Motivation)", + "output": "Stents, Tracheal, Metallic (Medical Device)" + }, + { + "input": "Definition: Breast Carcinoma described as the most common type of invasive breast cancer. It starts in the cells that line the milk ducts in the breast, grows outside the ducts, and often spreads to the lymph nodes.\nConcepts: Carcinomas, Infiltrating Duct (Mammary Neoplasms)\tProphylactic Bilateral Mastectomy (Prophylactic Mastectomy)\tdownregulation of chemotaxis (Cell Function)\tAbnormal shape of end part of lower limb end bone (Anatomical Abnormality)\tClassification Scheme (Conceptual Entity)", + "output": "Carcinomas, Infiltrating Duct (Mammary Neoplasms)" + }, + { + "input": "Definition: Histiocytic neoplasm described as rare malignant neoplasm of dendritic LANGERHANS CELLS exhibiting atypical cytology, frequent mitoses, and aggressive clinical behavior. They can be distinguished from other histiocytic and dendritic proliferations by immunohistochemical and ultrastructure studies. Cytologically benign proliferations of Langerhans cells are called LANGERHANS CELL HISTIOCYTOSIS.\nConcepts: Langerhans Cell Sarcomas (Histiocytic neoplasm)\tTAFII100 (Gene or Genome)\tProminent frontal ridges (Abnormal shape of the frontal region)\tMediastinal (Subdivision of thoracic compartment)\tStudyProtocolVersion.amendmentGracePeriod (Temporal Concept)", + "output": "Langerhans Cell Sarcomas (Histiocytic neoplasm)" + }, + { + "input": "Definition: regulation of type I interferon production described as any process that modulates the frequency, rate, or extent of interferon-beta production.\nConcepts: Japanese B Viral Encephalitis (Mosquito-borne flavivirus encephalitis)\tHTLV I ASSOC MYELOPATHY TROPICAL SPASTIC PARAPARESIS (Inflammation of specific body organs)\tregulation of IFN-beta production (Organism Function)\tfatty acyl-CoA reductase (alcohol-forming) activity (Molecular Function)\tFIQR0115 (FIQR Questionnaire Question)", + "output": "regulation of IFN-beta production (Organism Function)" + }, + { + "input": "Definition: something described as an element of the rare earth family of metals. It has the atomic symbol Pr, atomic number 59, and atomic weight 140.91.\nConcepts: PRASEODYMIUM (Element, Ion, or Isotope)\tConventional release vaginal cream (Biomedical or Dental Material)\tGrowth hormone, human (HGH) (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tOral (Anatomy Qualifier)\timinodiacetate dehydrogenase activity (oxidoreductase activity, acting on the CH-NH group of donors)", + "output": "PRASEODYMIUM (Element, Ion, or Isotope)" + }, + { + "input": "Definition: something described as a measurement of the German cockroach (Blattella germanica) antigen IgG4 antibody in a biological specimen.\nConcepts: Adrenal Cancer pT2 TNM Finding v7 (Finding)\tC130143 (Laboratory Procedure)\tTime Matched Derivation Indicator (Conceptual Entity)\tUnsure (Decision Making)\ttriglyceride biosynthesis (acylglycerol biosynthetic process)", + "output": "C130143 (Laboratory Procedure)" + }, + { + "input": "Definition: something described as an episode of cardiac arrest or arrhythmia where the etiology was unknown.\nConcepts: senecionine monooxygenase (N-oxide-forming) activity (Molecular Function)\tmonth of the year (Temporal context)\t3-(2-Cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one (Anticonvulsants, Other)\tCardiac Arrest/Arrhythmia Etiology Unknown (Finding)\tHypotonic Cerebral Palsies (Cerebral Palsy)", + "output": "Cardiac Arrest/Arrhythmia Etiology Unknown (Finding)" + }, + { + "input": "Definition: hexose biosynthetic process described as biosynthesis of glucose from 3-carbon precursors, including aminoacids (this is the basis of protein breakdown during starvation).\nConcepts: blood coagulation, thrombocyte activation (cell activation)\tD84 FAMILY CELASTRACEAE - STAFF-TREE (Trees and shrubs)\tTarsus Osseus (Bone structure of lower limb)\tNeoplasm by histology (Neoplasms)\tgluconeogenesis (Molecular Function)", + "output": "gluconeogenesis (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that 5 to 19 minutes were spent on an activity.\nConcepts: regulation of secondary metabolite biosynthetic process (Molecular Function)\tFive to Nineteen Activity Minutes (Clinical or Research Assessment Answer)\tPrimary Small Intestinal Non-Hodgkin's Lymphoma (Digestive System Non-Hodgkin Lymphoma)\tSporadic Diffuse Gastric Adenocarcinoma (Gastric Diffuse Adenocarcinoma)\tProtein S-Acetyltransferase, Acyl-Carrier (Enzyme)", + "output": "Five to Nineteen Activity Minutes (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as a prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.\nConcepts: Neuropeptide (cell communication molecule)\t9-(2-phosphonylmethoxyethyl)guanine nucleotide analogue prodrug GS 9219 (Purine antagonist)\tEGb 761 (Organic Chemical)\tBladder Non-Invasive Papillary Urothelial Carcinoma, High Grade (Non-invasive papillary urothelial carcinoma of bladder)\tLocally Advanced Large Cell Neuroendocrine Carcinoma (Metastatic Large Cell Neuroendocrine Carcinoma)", + "output": "9-(2-phosphonylmethoxyethyl)guanine nucleotide analogue prodrug GS 9219 (Purine antagonist)" + }, + { + "input": "Definition: stage/type, childhood brain tumor described as an ependymoma that occurs during childhood.\nConcepts: Aspect Ratio (Quantitative Concept)\tGOITER, MULTINODULAR, CYSTIC RENAL DISEASE, AND DIGITAL ANOMALIES (Disease or Syndrome)\tPediatric Ependymoma (Childhood Ependymal Tumor)\tUPD2107 (MDS-UPDRS Questionnaire Question)\tZip Code (Postal Code)", + "output": "Pediatric Ependymoma (Childhood Ependymal Tumor)" + }, + { + "input": "Definition: something described as terminology associated with the specimen type codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: CDISC SDTM Specimen Type Terminology (CDISC SDTM Terminology)\tOAB-q - Prevented You From Feeling Rested Upon Waking (Intellectual Product)\ttrifid subdivision of terminal units involved in ureteric bud branching (morphogenesis of an epithelium)\tpositive regulation by symbiont of host G-protein coupled receptor protein signal transduction (positive regulation of G protein-coupled receptor signaling pathway)\tNanolithography (Non-Clinical Nanoparticle Application)", + "output": "CDISC SDTM Specimen Type Terminology (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Benign adenomatous neoplasm - category described as a benign neoplasm arising from/comprising cells resembling those of bile ducts.\nConcepts: Subunit (Part)\tTUMOR-SUPPRESSING STF cDNA 1 (Gene or Genome)\tHaemodialysis machine, device (Electromechanical Devices)\tSarcomatoid Features (Finding)\tAdenoma, Bile Duct (Benign Neoplasm)", + "output": "Adenoma, Bile Duct (Benign Neoplasm)" + }, + { + "input": "Definition: pentosyltransferase activity described as catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate.\nConcepts: Cranial end of primnitive streak (Other Embryologic Structure)\tHEC (hydrocephalus, endocardial fibroelastosis, cataract ) syndrome (Disease or Syndrome)\tRight Tubo-Ovarian (Body Location or Region)\tphosphoribosylanthranilate transferase activity (pentosyltransferase activity)\tPercent Predicted DLCO (Finding)", + "output": "phosphoribosylanthranilate transferase activity (pentosyltransferase activity)" + }, + { + "input": "Definition: Neoplastic Process described as a clear cell sarcoma of soft tissue that has spread extensively to other anatomic sites or is no longer responding to treatment.\nConcepts: Visual fields plot (Procedure categorized by device involved)\tAdvanced Clear Cell Sarcoma of Soft Tissue (Advanced Soft Tissue Sarcoma)\tRisk For Dysfunctional Family Grief (Risk For Dysfunctional Grief)\tEPIC1-Problem Losing Control of Stools (EPIC-26 Questionnaire Question)\tAcute myeloblastic leukaemia with maturation (Basophilic leukemia)", + "output": "Advanced Clear Cell Sarcoma of Soft Tissue (Advanced Soft Tissue Sarcoma)" + }, + { + "input": "Definition: Pharmacologic Substance described as a recombinant fusion protein derived from the coding sequences of two growth factors, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF). Milodistim exhibits greater receptor binding affinity and colony stimulating activity than its parent cytokines. This agent stimulates proliferation of immature hematopoietic cells and allows the stimulation and expansion of multi-lineage hematopoiesis from immature bone marrow progenitor cells.\nConcepts: Transport Containers (Manufactured Object)\tmilodistim (Biological Response Modifiers)\tnegative regulation of response to benzene (negative regulation of response to stimulus)\tDefault (Conceptual Entity)\tClinical microbiology (Biomedical Occupation or Discipline)", + "output": "milodistim (Biological Response Modifiers)" + }, + { + "input": "Definition: something described as human SH3PXD2A wild-type allele is located in the vicinity of 10q25.1 and is approximately 267 kb in length. This allele, which encodes SH3 and PX domain-containing protein 2A, plays a role in the modulation of both signaling and cellular protrusion formation.\nConcepts: Supine position (Spatial Concept)\tFISH (SH3PXD2A gene)\tgamma-delta T-cell proliferation (Cell Function)\tN-Acetylglucosaminyltransferase IVc (Amino Acid, Peptide, or Protein)\tOptional (Qualitative Concept)", + "output": "FISH (SH3PXD2A gene)" + }, + { + "input": "Definition: Pharmacologic Substance described as a synthetic non-cardiotoxic analogue of the anthracycline antibiotic doxorubicin with potential antineoplastic activity. Camsirubicin intercalates DNA and impedes the activity of topoisomerase II, inducing single and double-stranded breaks in DNA; inhibiting DNA replication and/or repair, transcription, and protein synthesis; and activating tumor cell apoptosis.\nConcepts: Traditional Indigenous System (Alternative Medical System)\tpositive regulation of fatty acid transport (positive regulation of anion transport)\t5-Imino-13-deoxydoxoubicin (Pharmacologic Substance)\tWorld Monkeys, New (Anthropoidea)\tlongitudinal cilium (9+2 motile cilium)", + "output": "5-Imino-13-deoxydoxoubicin (Pharmacologic Substance)" + }, + { + "input": "Definition: Measurement Unit Description described as days times micromoles per liter (area under the curve), divided by kilograms (weight) or days times nanomoles per liter (area under the curve), divided by grams (weight).\nConcepts: Inferior rectus muscle overaction (Abnormal inferior rectus muscle physiology)\tIncreased urinary fucosylated oligosaccharide (Finding)\tCSMD3 (Amino Acid, Peptide, or Protein)\tAbsence of menstruation (Abnormality of the menstrual cycle)\tday*nmol/L/g (Measurement Unit Description)", + "output": "day*nmol/L/g (Measurement Unit Description)" + }, + { + "input": "Definition: something described as cervical cancer with no regional lymph node metastasis.\nConcepts: Idioventricular Rhythm, Accelerated (Ventricular arrhythmia)\tpositive regulation of Th2 cell activation (regulation of T-helper 2 cell activation)\tGerminomas (Neoplastic Process)\tCervical Cancer cN0 TNM Finding v7 (Cervical Cancer Clinical Regional Lymph Nodes TNM Finding v7)\tBasement Membrane-Specific Heparan Sulfate Proteoglycan Core Protein (Extracellular Matrix Proteins)", + "output": "Cervical Cancer cN0 TNM Finding v7 (Cervical Cancer Clinical Regional Lymph Nodes TNM Finding v7)" + }, + { + "input": "Definition: something described as the behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg.\nConcepts: Local Therapy (Therapeutic or Preventive Procedure)\tKPT-8602 (Organic Chemical)\tadult walking behaviour (adult locomotory behavior)\tlarval serum protein complex location (protein-containing complex)\tCarcinostatic (General Qualifier)", + "output": "adult walking behaviour (adult locomotory behavior)" + }, + { + "input": "Definition: HAM-D6 Self-Report Version Questionnaire Question described as hamilton Depression Rating Scale 6 Self-Report Version (HAM-D6 Self-Report Version) (1)=Depressed mood per clinician version: How you have been feeling over the past three days, including today.\nConcepts: Esophagus and Esophagogastric Junction Cancer pT1b TNM Finding v7 (Finding)\tMetastatic Well Differentiated Neuroendocrine Neoplasm (Neoplastic Process)\tamputation toes (Procedure on foot)\tRGS19 (RGS Proteins)\tHAMDS1-Depressed Mood (HAM-D6 Self-Report Version Questionnaire Question)", + "output": "HAMDS1-Depressed Mood (HAM-D6 Self-Report Version Questionnaire Question)" + }, + { + "input": "Definition: cleavage apparatus septin structure described as two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.\nConcepts: Antineoplastons (Differentiation Inducer)\tnegative regulation of glucose fermentation to ethanol (negative regulation of cellular carbohydrate metabolic process)\tanterior part of the brainstem (Body Part, Organ, or Organ Component)\tcellular bud neck split septin rings (cleavage apparatus septin structure)\tLassa haemorrhagic fever (Skin and subcutaneous tissue viral infections)", + "output": "cellular bud neck split septin rings (cleavage apparatus septin structure)" + }, + { + "input": "Definition: Career Areas described as a subspecialty of psychiatry concerned with the mental health of the aged.\nConcepts: MUSCLES OF TRUNK (Skeletal muscle structure)\tLymphocytosis, NOS (Lymphocyte count abnormal)\tPsychiatry, Geriatric (Medical & Physical Treatment)\tGonadal dysgenesis (Female internal genitalia structure)\tDRRI-2 - F: Took Preventative Pills (Intellectual Product)", + "output": "Psychiatry, Geriatric (Medical & Physical Treatment)" + }, + { + "input": "Definition: cellular biosynthetic process described as the chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings).\nConcepts: SOWSA106 (SOWS Subjective Questionnaire Question)\tPubocervical ligament (Body Part, Organ, or Organ Component)\tP1 Hydronephrosis (Finding)\theterocycle formation (Molecular Function)\tovales, Plasmodium (Plasmodium )", + "output": "heterocycle formation (Molecular Function)" + }, + { + "input": "Definition: something described as human ABCB1 wild-type allele is located in the vicinity of 7q21.1 and is approximately 210 kb in length. This allele, which encodes multidrug resistance protein 1, is involved in transmembrane transport. Amplification of the ABCB1 gene is a major determinant in the development of multi-drug resistance, which decreases the effectiveness of many chemotherapeutic agents used in cancer treatment.\nConcepts: Fluocinonida (fluocinolone)\tUHDRS 1999 Version - Functional Assess Obtained From (UHDRS 1999 Version Clinical Classification Question)\tspongiotrophoblast layer development (reproductive structure development)\tATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 wt Allele (Gene or Genome)\tFenitrothion (Organothiophosphorus Compounds)", + "output": "ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein.\nConcepts: EMO112C (Intellectual Product)\toxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor (Molecular Function)\tcell-matrix adhesion involved in tangential migration using cell-cell interactions (cell-substrate adhesion)\tEMBOLISMS PULM (Pulmonary embolism and thrombosis)\tGreat War (History, 20th Century)", + "output": "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor (Molecular Function)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual is or was very short of breath.\nConcepts: plasma serine protease inhibitor-coagulation factor V complex (serine protease inhibitor complex)\tarea 8 beta of Vogts (Body Location or Region)\tVery Short of Breath (Clinical or Research Assessment Answer)\tcontactAnatomicSiteCode (Intellectual Product)\tDerung Chinese (Population Group)", + "output": "Very Short of Breath (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: M [Preparations] described as a neurokinin receptor antagonist with antiemetic activity. This agent is approved for veterinary use only.\nConcepts: HU Protein (Biologically Active Substance)\tQc SNARE Proteins (Biologically Active Substance)\tMaropitant Citrate (M [Preparations])\trHuKGF (P [Preparations])\tphosphomutase activity (Molecular Function)", + "output": "Maropitant Citrate (M [Preparations])" + }, + { + "input": "Definition: HEART: MUSCLE/VALVE described as excessive accumulation of extravascular fluid in the lung, an indication of a serious underlying disease or disorder. Pulmonary edema prevents efficient PULMONARY GAS EXCHANGE in the PULMONARY ALVEOLI, and can be life-threatening.\nConcepts: IMP 5' nucleotidase activity (Molecular Function)\tSuperficial Thrombophlebitis (Cardio-vascular Findings: Peripheral Arteries)\tEDEMA LUNG (Lower respiratory tract disorders)\tM87o-Transduced CD34+ PBSC (therapeutic autologous lymphocytes)\tneutropenic fever (Febrile leukopenia)", + "output": "EDEMA LUNG (Lower respiratory tract disorders)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a type of therapy in which lymphocytes from the blood of a donor are given to a patient who has already received a stem cell transplant from the same donor. The donor lymphocytes may kill remaining cancer cells. Donor lymphocyte infusion is used to treat chronic myelogenous leukemia (CML) that has come back and myeloma. It is being studied in the treatment of other types of cancer.\nConcepts: Donor Lymphocyte Infusion (Therapeutic or Preventive Procedure)\tUnknown Molecular Analysis (CPTAC Responses)\tVibrio sputigenus (Sarcina)\tVisceral Somatic Dysfunction (Somatic dysfunction)\tAlanine Nitrogen Mustard (Amino Acid, Peptide, or Protein)", + "output": "Donor Lymphocyte Infusion (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as physical measurement or determination.\nConcepts: Physical (Bibliographic Reference)\trndx community coping impairment (Difficulty coping)\tBIOAVAILABILITY (Human Pharmacology Study)\tcalcium-dependent protein serine/threonine phosphatase activity (protein serine/threonine phosphatase activity)\tIntense psychological distress to cues (Intrusion symptom)", + "output": "Physical (Bibliographic Reference)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 20p\nConcepts: Criminal Law (Laws)\tASK-1 (MAP3K5 gene)\t20p11.2 (Chromosome band)\tAdditional Surgery for New Loco-Regional Tumor Event Was Not Performed (Finding)\tAVL01075 (ADNI-AVLT Questionnaire Question)", + "output": "20p11.2 (Chromosome band)" + }, + { + "input": "Definition: Pharmacologic Substance described as a formulation of the semisynthetic vinca alkaloid, vinorelbine, encapsulated within liposomes, with antineoplastic activity. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in cell cycle arrest in metaphase. Like other vinca alkaloids, vinorelbine may also interfere with the metabolism of nucleic acids, lipids, amino acids, cAMP, and glutathione, as well as other biological processes including calmodulin-dependent Ca2+-transport, ATPase activity, or cellular respiration. Liposomal delivery of vinorelbine improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile.\nConcepts: carcinoma of penis (Carcinoma of genital organ)\tGrade 4 Uterus hemorrhage (Uterine Hemorrhage, CTCAE)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, IKBKAP (Medical Device)\tvinorelbine liposomes injection (Pharmacologic Substance)\tEsophagus and Esophagogastric Junction Cancer pT2 TNM Finding v8 (Finding)", + "output": "vinorelbine liposomes injection (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.\nConcepts: Compounds, Sulfonium (Onium Compounds)\tGrade 1 Blood corticotrophin decreased (Finding)\tSpeckled calcifications in end part of the outermost long bone of the middle finger (Stippling of the epiphyses of the distal phalanges of the hand)\tAdjacent to relation (Anatomical location)\tD4DR Gene (DRD4 gene)", + "output": "Compounds, Sulfonium (Onium Compounds)" + }, + { + "input": "Definition: Affiliate Realms described as a country in southeastern Asia, comprised of the southern tip of the Malaysian peninsula and nearby islands between Malaysia and Indonesia.\nConcepts: SINGAPORE (Asia, Southeastern)\tnegative regulation of germ tube formation on or near host (negative regulation of spore germination on or near host)\tAmma therapy each 15 minutes (Oriental massage)\tRas (sub 5-17) Peptide (Amino Acid, Peptide, or Protein)\tPersonality;inadequate (General mental state)", + "output": "SINGAPORE (Asia, Southeastern)" + }, + { + "input": "Definition: something described as a measurement of the complement C5b-9 in a biological specimen.\nConcepts: C 5b-9 (Terminal complement pathway factor)\tLow tissue non-specific ALP (Low alkaline phosphatase)\tStage IIA Sarcoma of the Soft Tissue (Stage II Soft Tissue Sarcoma AJCC v7)\tBLADDER: EXCISIONS (Excision from urinary tract)\tLiver Complete Response GvHD (Finding)", + "output": "C 5b-9 (Terminal complement pathway factor)" + }, + { + "input": "Definition: receptor recycling described as the process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.\nConcepts: FAC01612 (FACT-L Version 4 Questionnaire Question)\tWnt receptor recycling (Cell Function)\tTablet and Powder for Oral Solution Dosage Form (Combined Dosage Form)\tYT (South east African country)\tOrally (Head)", + "output": "Wnt receptor recycling (Cell Function)" + }, + { + "input": "Definition: something described as any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism.\nConcepts: Physician Assistant (Medical Occupation)\tVideo/Audio Signal Amplifiers (Manufactured Object)\tPectoralis hypoplasia (Pectoral muscle hypoplasia/aplasia)\t(3R,4R,5E,10E,12E,14S,26R,26aS)-26-((2-(diethylamino)ethyl)sulfonyl)-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone (Allergen class)\tpositive regulation of acid-sensing ion channel in other organism (Biologic Function)", + "output": "positive regulation of acid-sensing ion channel in other organism (Biologic Function)" + }, + { + "input": "Definition: something described as an oblique plane through the heart containing its long axis and showing 2 chambers. Also any plane parallel to this can be called a vertical long axis view.\nConcepts: Delay in central nervous system myelination (Delayed myelination)\tJoint Movement: Neck (Mobility as a finding)\tL-asparagine metabolism (asparagine metabolic process)\tFlaxseed (Non-Standardized Plant Allergenic Extract)\tVertical Long Axis (Long axis)", + "output": "Vertical Long Axis (Long axis)" + }, + { + "input": "Definition: Cell physiology described as involves the growth and reproduction of similar cells by cell division, resulting in an increase in cell number.\nConcepts: Physicians - Obstetrics & Gynecology (Professional or Occupational Group)\tReference Point (Reference Object)\tCell Proliferation (Cytology)\tNucleus dorsointermedius superior (Body Part, Organ, or Organ Component)\tRPQ - Any Other Difficulties 2 (RPQ Questionnaire Question)", + "output": "Cell Proliferation (Cytology)" + }, + { + "input": "Definition: something described as transcription initiation factor TFIID subunit 5 (800 aa, ~87 kDa) is encoded by the human TAF5 gene. This protein plays a role in the assembly of the basal transcription apparatus.\nConcepts: Organ cluster (Anatomical cluster)\tvasomotor (Functional Concept)\tTBP-Associated Factor RNA Polymerase II D 100kD (Amino Acid, Peptide, or Protein)\tsulphathiazole transporter activity (azole transmembrane transporter activity)\tTERT 1 295 228 C>T (Cell or Molecular Dysfunction)", + "output": "TBP-Associated Factor RNA Polymerase II D 100kD (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Enzyme described as histone H2A deubiquitinase MYSM1 (828 aa, ~95 kDa) is encoded by the human MYSM1 gene. This protein is involved in the deubiquitination of histone 2A, which leads to chromatin remodeling and transcriptional activation.\nConcepts: Physostigma Balf (Fabaceae)\tHave Trouble Forming Thoughts (Clinical or Research Assessment Question)\tMYSM1 protein, human (Metalloproteases)\tViral Occlusion Bodies (Viral Structures)\tFetal akinesia sequence (Reduced fetal movement)", + "output": "MYSM1 protein, human (Metalloproteases)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1).\nConcepts: troponin I binding (Molecular Function)\tCDC42 Binding Protein Kinase Alpha (DMPK-Like) Gene (CDC42BPA gene)\t2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5- triazin-2-yl)amino]propan-2-ol methanesulfonate (Aminopyridine)\tsucrose 6-fructosyl transferase activity (hexosyltransferase activity)\tN,1,4,4-Tetramethyl-8-((4-(4-methylpiperazin-1-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo(4,3-h)quinazoline-3-carboxamide (Organic Chemical)", + "output": "sucrose 6-fructosyl transferase activity (hexosyltransferase activity)" + }, + { + "input": "Definition: Medical Device described as reagents available as home-test kits that permit the determination of chlorides in a sample of urine. Chloride determination kits for home use permit patients to check and/or control the level of chloride during illness (e.g., adrenocortical) and/or medical treatments (e.g., diets).\nConcepts: Heart sound abnormal (Abnormal cardiovascular system physiology)\tPeriodontal Screening and Recording Code 1 (Periodontal Screening and Recording Code)\tAspartate Beta-Hydroxylase-Positive Neoplastic Cells Present (ASPH Positive)\tIVD Test Reagent/Kits, Home Assay, Urine, Chloride (IVD Test Reagent/Kits, Home Assay, Urine)\tPeriodic Target Accrual Number (Numbers)", + "output": "IVD Test Reagent/Kits, Home Assay, Urine, Chloride (IVD Test Reagent/Kits, Home Assay, Urine)" + }, + { + "input": "Definition: something described as a response of an organism to a fungus that prevents the occurrence or spread of disease.\nConcepts: optic chiasm (Visual Pathways)\tresistance response to pathogenic fungus (defense response, incompatible interaction)\tFAC005TC (Intellectual Product)\tWatery bowel movements (Intellectual Product)\tONCOLOGIST 1 (Professional or Occupational Group)", + "output": "resistance response to pathogenic fungus (defense response, incompatible interaction)" + }, + { + "input": "Definition: Embryonic Structure described as an extraembryonic membrane in the form of a sac. It collects waste from the embryo.\nConcepts: Structure of allantois (Extraembryonic membranes)\tPatchy sclerosis of the proximal phalanx of the 2nd finger (Finding)\tC-SSRS Lifetime/Recent Version - Aborted Suicide Attempt (Intellectual Product)\tRetinoblastoma cNX TNM Finding v7 (Finding)\tAdvanced Gastroenteropancreatic Neuroendocrine Neoplasm (Advanced Neuroendocrine Neoplasm)", + "output": "Structure of allantois (Extraembryonic membranes)" + }, + { + "input": "Definition: Hereditary disorder of nervous system described as this syndrome has characteristics of intellectual deficit, calcification of the choroid plexus and elevated levels of cerebrospinal fluid protein. It has been described in two sibships from two unrelated families. The seven children of one of the sibships were born to consanguineous parents. Some patients also had strabismus, hyperactive deep tendon reflexes and foot deformities.\nConcepts: Oculoplastic Surgery (Therapeutic or Preventive Procedure)\tTuberculosis, Osteoarticular (Bacterial musculoskeletal infection)\tChoroido-cerebral calcification syndrome with retardation (Extraskeletal calcification)\t2019-nCoV Vaccines (Amino Acid, Peptide, or Protein)\tmagnetic affinity cell sorting (Cell Separation)", + "output": "Choroido-cerebral calcification syndrome with retardation (Extraskeletal calcification)" + }, + { + "input": "Definition: something described as the process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores.\nConcepts: spore-bearing structure formation (Physiologic Function)\tConcentrate for Dip Emulsion Dosage Form (Biomedical or Dental Material)\tPoliovirus (Virus)\tARQ-736 (Antineoplastic Enzyme Inhibitor)\tNotochordal Canal (Embryonic space)", + "output": "spore-bearing structure formation (Physiologic Function)" + }, + { + "input": "Definition: Face described as excessive amount of hair growth on forehead.\nConcepts: Grade 3 Peripheral Nerve Infection, CTCAE (Finding)\ttermination of MAP kinase kinase kinase activity (negative regulation of MAPK cascade)\tFrontal hirsutism (Skin, Human)\tWD4-Living Situation at Interview (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\t4: 77285820-77279802 (Chromosome 4 Physical Location)", + "output": "Frontal hirsutism (Skin, Human)" + }, + { + "input": "Definition: response to polyamine macromolecule described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a polyamine macromolecule stimulus.\nConcepts: detection of monosaccharide stimulus (Cell Function)\talpha interferon (Amino Acid, Peptide, or Protein)\tCystoscopes, Rigid (Medical Device)\tEndomet intraepithl neop (Abdominal Neoplasms)\tcellular response to polyamine (cellular response to organonitrogen compound)", + "output": "cellular response to polyamine (cellular response to organonitrogen compound)" + }, + { + "input": "Definition: Agriculture described as a systematic process of adapting wild species of animals and plants into new environments often in close association or proximity to humans.\nConcepts: castration (Ablative Endocrine Surgery)\tDomestication (Agriculture)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ATM (Medical Device)\tVideo-Based 3D Surface Imaging (Diagnostic Procedure)\tKRAS1 c.37G>C (Cell or Molecular Dysfunction)", + "output": "Domestication (Agriculture)" + }, + { + "input": "Definition: Intellectual Product described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Prostate Symptom Index 17 Version 2 (NCCN-FACT-FPSI 17 Version 2) I have a good appetite.\nConcepts: Hard Vaginal Capsule Dosage Form (Biomedical or Dental Material)\t20: 57015697-57003635 (Chromosome 20 Physical Location)\tupright (Orientation)\tPalliative care nurse (Discipline of Nursing)\tFAC05209 (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)", + "output": "FAC05209 (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: Central gray substance described as the dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei (HABENULA) and associated fiber bundles, the PINEAL BODY, and the epithelial roof of the third ventricle. The anterior and posterior paraventricular nuclei of the thalamus are included with the THALAMIC NUCLEI although they develop from the same pronuclear mass as the epithalamic nuclei and are sometimes considered part of the epithalamus.\nConcepts: late endosome lumen (Cell Component)\tnegative regulation of osmosensory signaling pathway (regulation of osmosensory signaling pathway)\tEstrogen Receptor Positive by Immunohistochemistry 91-100 Percent (Laboratory or Test Result)\tA49 EPITHALAMUS (Brain part)\tNon-Human Papillomavirus-Related Squamous Cell Carcinoma of the Penis (Squamous Cell Carcinoma of the Penis)", + "output": "A49 EPITHALAMUS (Brain part)" + }, + { + "input": "Definition: undecylenic acid described as the calcium salt of undecylenic acid, an 11 carbon mono-unsaturated fatty acid with broad-spectrum antifungal activity. Undecylenic acid inhibits the morphogenesis of Candida albicans to its invasive fungal form and inhibits the conversion of unicellular yeast to their hyphal form.\nConcepts: HAQ0233 (Intellectual Product)\tGrade 3 Ovarian rupture (Ovarian Rupture, CTCAE)\tCalcium Undecylenate (dermatological antifungal agents)\tERCC3 protein, human (DNA repair protein)\tCSS1115B (C-SSRS Lifetime/Recent Version Questionnaire Question)", + "output": "Calcium Undecylenate (dermatological antifungal agents)" + }, + { + "input": "Definition: something described as this gene is involved in mitosis.\nConcepts: FAC100-Sev: Walk 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tregulation of cellular component biogenesis (Cell Function)\tMAD2L1 gene (Gene or Genome)\tAbnormal circulating phytanic acid level (Finding)\tBracket shaped end part of the outermost pinkie finger bone (Abnormality of the epiphysis of the distal phalanx of the 5th finger)", + "output": "MAD2L1 gene (Gene or Genome)" + }, + { + "input": "Definition: something described as a chemotherapy regimen consisting of cyclophosphamide, doxorubicin, methotrexate, and procarbazine that may be used in the treatment of non-small cell lung cancer (NSCLC).\nConcepts: In the past 7 days, what was the severity of your watery eyes (tearing) at their worst (Intellectual Product)\tNPI1-Hallucinations Frequency (Intellectual Product)\tCyclophosphamide-Doxorubicin-Methotrexate-Procarbazine (Regimen Used to Treat Non-Small Cell Lung Carcinoma)\tInterfilar connective tissue of tricuspid valve (Subdivision of fibrous skeleton of heart)\tGreater trochanter (Trochanter of femur)", + "output": "Cyclophosphamide-Doxorubicin-Methotrexate-Procarbazine (Regimen Used to Treat Non-Small Cell Lung Carcinoma)" + }, + { + "input": "Definition: Transcription Repressor/Corepressor Gene described as this gene is involved in transcriptional repression.\nConcepts: Biospecimens Not Retained (Conceptual Entity)\tIL-4-mediated signaling pathway (cytokine-mediated signaling pathway)\tsecretion associated Ras related GTPase 1B (G Protein Gene)\ttransducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) (Transcription Repressor/Corepressor Gene)\tChromogranin Gene (Peptide Hormone Gene)", + "output": "transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila) (Transcription Repressor/Corepressor Gene)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as having undesirable or negative qualities.\nConcepts: microtubule plus-end (Cardinal cell part)\tEstra-4,9,11-trien-3-one, 17-hydroxy-17-methyl-, (17beta)- (Pharmacologic Substance)\tBadly (Qualitative Concept)\teach day (Time frame)\tPlesiomonas species (unclassified Enterobacterales)", + "output": "Badly (Qualitative Concept)" + }, + { + "input": "Definition: something described as a variant of neurofibromatosis type 1 characterized by the combination of features of neurofibromatosis type 1, such as caf\u00e9-au-lait spots, iris Lisch nodules, axillary and inguinal freckling, optic nerve glioma and multiple neurofibromas; and Noonan syndrome, with features such as short stature, typical facial features, congenital heart defects and unusual pectus deformity.\nConcepts: Neurofibromatosis with Noonan phenotype (Disease or Syndrome)\tEndothelial Differentiation, G Protein Coupled Receptor 6 (Receptor)\tWHO Clinical Staging of HIV/AIDS for Adults and Adolescents Clinical Classification Test Name (CDISC Clinical Classification Terminology)\tSmall Intestinal Angiosarcoma (sarcoma of small intestine)\tdysgranular cortex (Body Part, Organ, or Organ Component)", + "output": "Neurofibromatosis with Noonan phenotype (Disease or Syndrome)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Child Parent Report - In the past 7 days, how much of a problem has this been for your child: My child takes a long time to eat.\nConcepts: suppression by virus of host mitochondrial antiviral-signaling protein (suppression by virus of host molecular function)\tPQL1515 (Intellectual Product)\tEmerging Technologies (Qualitative Concept)\tChildhood AML with NUP98 Rearrangement (Neoplastic Process)\ttherapeutic allogeneic lymphocytes (Lymphocyte)", + "output": "PQL1515 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 1 on a scale that ranges from 0: Health problems had no effect on my work to 10: Health problems completely prevented me from working.\nConcepts: Clotting disorders (Abnormality of coagulation)\thsa-mir-1208 (Gene or Genome)\tHealth Problems Effect on Work Score 1 (Intellectual Product)\tIPA0305B (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tLabor induction pharmaceutical initial 60 minutes (Obstetric Delivery)", + "output": "Health Problems Effect on Work Score 1 (Intellectual Product)" + }, + { + "input": "Definition: Electromyogram abnormal described as continuous electromyographic activity of motor units at rest, i.e., without voluntary movement of the muscles.\nConcepts: EMG: continuous motor unit activity at rest (Finding)\tTrial Arms Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)\tacetyl-CoA anabolism from pantothenate (pantothenate metabolic process)\tcervical orthosis (Medical Device)\tUFM1 conjugating enzyme activity (Molecular Function)", + "output": "EMG: continuous motor unit activity at rest (Finding)" + }, + { + "input": "Definition: Extracellular Fluid described as transudate contained in the vesicular ovarian follicle (TA) (Graafian follicle).\nConcepts: Intrahepatic Bile Duct Microcystic Adenoma (adenoma of intrahepatic bile duct)\tHYDROXYDOPAMINE 06 (Pharmacologic Substance)\tchromoshadow domain binding (Molecular Function)\tpolyvinylpyrrolidone-sodium hyaluronate gel (Pharmacologic Substance)\tFollicular Fluids (Portion of body fluid suspension)", + "output": "Follicular Fluids (Portion of body fluid suspension)" + }, + { + "input": "Definition: something described as helping a client in drawing on spiritual resources to deepen his or her spirituality and/or improve his or her health. Service is billed in 15-minute increments.\nConcepts: Spiritual encouragement individual each 15 minutes (Multidenominational care)\tPET - Positron emission tomography (Imaging Techniques)\tHistone 2A (Biologically Active Substance)\tNectin Cell Adhesion Molecule 2 Gene (Cell Adhesion Molecule Gene)\tdown regulation of cytotoxic T cell degranulation (Cell Function)", + "output": "Spiritual encouragement individual each 15 minutes (Multidenominational care)" + }, + { + "input": "Definition: Myalgia described as a complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include EOSINOPHILIA, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn WD, Semin Arthritis Rheum 1997 Jun;26(6):788-93)\nConcepts: Osteosclerosis, diffuse symmetrical (Osteosclerosis)\tviruses (General Qualifier)\tDENSITOMETERIC, PROTEIN FRACTIONATION (Medical Device)\tspheroplasts (Cells)\teosinophilia myalgia syndrome (Myositis)", + "output": "eosinophilia myalgia syndrome (Myositis)" + }, + { + "input": "Definition: Numbers described as a measurement of the number of live fetuses in the uterus.\nConcepts: plastid ribosome (Cell Component)\tFETLVNUM (Numbers)\tnegative regulation of serine-type peptidase activity (regulation of serine-type peptidase activity)\tHPV-Related Endocervical Adenocarcinoma (Human Papillomavirus-Related Adenocarcinoma)\tGrade 2 Pharyngeal Hemorrhage, CTCAE (Finding)", + "output": "FETLVNUM (Numbers)" + }, + { + "input": "Definition: Manufactured Object described as filing cabinets designed for vertical storage of large documents. These cabinets typically consist of metallic or, less frequently, wooden structures that have drawers with hanging clamps and/or folders for storage of several large sheet documents. Large-document vertical hanging filing cabinets are typically used to store documents larger than standard letter or legal size, such as computer drawings (e.g., 11 x 17 inch/28 x 43 cm), blueprints (usually up to 14 x 18 inches/36 x 45 cm), maps, artwork, and large radiographic (i.e., x-ray) films.\nConcepts: COMP Regimen (Therapeutic or Preventive Procedure)\tDECOD (Terminology Entity)\tCabinets, Filing, Large Document, Vertical Storage (Cabinets, Filing, Large Document)\tPODCI154 (Intellectual Product)\tCNS tumor, oligodendroglioma, adult (Well Differentiated Oligodendroglioma)", + "output": "Cabinets, Filing, Large Document, Vertical Storage (Cabinets, Filing, Large Document)" + }, + { + "input": "Definition: HAQ-DI Without VAS Questionnaire Question described as health Assessment Questionnaire Disability Index Without Pain Visual Analog Scale - Aids or devices that you usually use for any of these activities: Other.\nConcepts: chitosome membrane (Cell Component)\tHAQ0240 (Intellectual Product)\tGastric Cancer cM1 TNM Finding v7 (Gastric Cancer Clinical Distant Metastasis TNM Finding v7)\tGrade 2 Libido decreased (Finding)\tSubmandibular Gland Acinic Cell Carcinoma (Submandibular Gland Adenocarcinoma)", + "output": "HAQ0240 (Intellectual Product)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as a terminology codelist to describe the test name for a physiological examination of the musculoskeletal system.\nConcepts: MUSCTS (CDISC SDTM Terminology)\tDeep cervical lymph node (Body Part, Organ, or Organ Component)\tregulation of attachment of spindle microtubules to kinetochore involved in mitosis (regulation of metaphase plate congression)\tRHEPDGFRA Positive (PDGFR Positive)\t4-hydroxyphenylacetaldehyde-oxime isomerase activity (cis-trans isomerase activity)", + "output": "MUSCTS (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of t-SNARE clustering.\nConcepts: RADIOIMMUNOASSAY, DIGITOXIN (Medical Device)\tHas the patient been hospitalized or treated for heart failure (Intellectual Product)\tup-regulation of t-SNARE clustering (positive regulation of protein localization to membrane)\tpositive regulation of chylomicron remodeling (regulation of chylomicron remodeling)\tregulation of de novo NAD biosynthetic process from tryptophan (Molecular Function)", + "output": "up-regulation of t-SNARE clustering (positive regulation of protein localization to membrane)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, Severe Dementia Version - Sum of Items 13-15.\nConcepts: Vend RR (Document type)\tAcoustic radiation (Sensory pathway structure)\tADL0223 (Intellectual Product)\tNitrophenol (Phenols)\tGrowth (Action)", + "output": "ADL0223 (Intellectual Product)" + }, + { + "input": "Definition: Regulation or Law described as a genotoxicity study that tests the ability of a substance to cause DNA damage not in intact animals, but in cells or other systems.\nConcepts: Genotoxicity: In Vitro (Regulation or Law)\tAblation for Barrett's Esophagus (Ablation)\tregulation of histone H4 acetylation at K16 (regulation of histone H4 acetylation)\tUnknown If Ever Smoked (Smoking Status)\tNF-E1 Exon 3 Mutation (Cell or Molecular Dysfunction)", + "output": "Genotoxicity: In Vitro (Regulation or Law)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a layer of the CA3 field as identified by MRI in the macaque (Macaque Brain by Dubach-2008). It corresponds to the combination of the pyramidal cell layer of the hippocampus and the oriens layer of the hippocampus in the CA3 field.\nConcepts: Gilbertese Language (Austronesian Language)\ttriple screen (serum hormone levels)\tErythropoietin Receptors (Amino Acid, Peptide, or Protein)\tstratum pyramidale of the CA3 field (pyramidal cell layer of the hippocampus)\tRadiation of Chest Pain (ACC-AHA Measure)", + "output": "stratum pyramidale of the CA3 field (pyramidal cell layer of the hippocampus)" + }, + { + "input": "Definition: Finding described as a disorder characterized by a circumscribed, erosive lesion on the mucosal surface of the small intestine.\nConcepts: SigmaN, RNA Polymerase (Bacterial Proteins)\tInsulin-like growth factor binding protein 3 measurement (Hormone measurement)\tSmall Intestine Ulcer, CTCAE (Finding)\tWater--Microbiology (Phenomenon or Process)\tObelion (Midline anatomical point of skull)", + "output": "Small Intestine Ulcer, CTCAE (Finding)" + }, + { + "input": "Definition: something described as specifies whether the margins of surgical resection are infiltrated by the abnormal tissue. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: PerformedHistopathologyResult.involvedSurgicalMarginIndicator (Involved Surgical Margin Indicator)\tRisk for disturbed maternal-fetal dyad (Reproduction)\tIMMUNOOSSEOUS DYSPLASIA, SCHIMKE TYPE (Immuno-osseous dysplasia)\tBIURET (COLORIMETRIC), TOTAL PROTEIN (Medical Device)\tGrade 4 Culture Negative Neonatal Sepsis (Finding)", + "output": "PerformedHistopathologyResult.involvedSurgicalMarginIndicator (Involved Surgical Margin Indicator)" + }, + { + "input": "Definition: something described as a mode of inheritance that is observed for traits related to a gene encoded on the X chromosome.\nConcepts: Grade 3 Suicide attempt (Finding)\tDrosophila simulans (Drosophila )\tInheritance, X Linked (Genetic Function)\tIllustration Graphic Art Publication and Audiovisual Service Shared Resource (Health Care Related Organization)\tASSAY, GLUTATHIONE REDUCTASE (Indicator, Reagent, or Diagnostic Aid)", + "output": "Inheritance, X Linked (Genetic Function)" + }, + { + "input": "Definition: Neuromuscular Diseases described as a rare syndromic genetic deafness with characteristics of a combination of muscle weakness, chronic neuropathic and myopathic features, hoarseness and sensorineural hearing loss. A wide range of disease onset and severity has been reported even within the same family. There is evidence the disease is caused by heterozygous mutation in the MYH14 gene on chromosome 19q13.\nConcepts: Peripheral neuropathy, myopathy, hoarseness, deafness syndrome (Autosomal dominant hereditary disorder)\thost invasion (movement in host environment)\tSTENT, COLONIC, METALIC, EXPANDABLE (Medical Device)\tStretchers, Portable, Scoop (Portable stretcher)\tHeteropolymer (Chemical Viewed Structurally)", + "output": "Peripheral neuropathy, myopathy, hoarseness, deafness syndrome (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: Ann Arbor lymphoma staging system described as a clinical stage that refers to lymphoma involving two or more node regions on the same side of the diaphragm or a single extranodal organ plus its regional lymph nodes with or without other nodes on the same side of the diaphragm (IIe).\nConcepts: Stage II (Ann Arbor lymphoma staging system)\tMethylprednisolone preparation (Adrenal Cortex Hormones)\tMitochondrial myopathy, lactic acidosis, deafness syndrome (Mitochondrial Myopathies)\tThoracic viscus (Structure of thoracic cavity and/or content)\tTumescent Mastectomy (Mastectomy)", + "output": "Stage II (Ann Arbor lymphoma staging system)" + }, + { + "input": "Definition: something described as encephaloscopes with a nonflexible (i.e., rigid) structure that can follow only a straight path into the cranium; they consist of thin (e.g., 4 mm diameter) endoscopes that are available with different directions of view (e.g., 30 or 120 degrees) enabling direct examination of the cerebral ventricles (i.e., ventriculoscopy) and inspection of cystic tumors.\nConcepts: c-K-ras Positive (Positive Laboratory Test Result)\tSubject Elements Supplemental Qualifiers Dataset (Intellectual Product)\tEOSNSQE (Laboratory Procedure)\tNCRNA00295 (Long Intergenic Non-Protein Coding RNA)\tEncephaloscopes, Rigid (Encephaloscopes)", + "output": "Encephaloscopes, Rigid (Encephaloscopes)" + }, + { + "input": "Definition: something described as age of subject (in days) when their neutrophil count exceeded a threshold of 500 (ANC/mm3) during the course.\nConcepts: Age in Days at Course ANC 500 (Finding)\tMDR Modulator CBT-1 (Pharmacologic Substance)\tSulfituria (Enzymopathy)\tZygomaticus major muscle (Skeletal muscle structure of head)\tRESIN, ION-EXCHANGE, ASCORBIC ACID, COLORIMETRY, IRON BINDING CAPACITY (Indicator, Reagent, or Diagnostic Aid)", + "output": "Age in Days at Course ANC 500 (Finding)" + }, + { + "input": "Definition: Memory loss described as a psychotic syndrome caused by damage to the brain by lack of thiamine (vitamin B1). Signs and symptoms include anterograde and retrograde amnesia, confabulation, apathy, ataxia, and coma.\nConcepts: AAD (aminoglycoside nucleotidyltransferase activity)\tgastric esophageal varices (Esophageal Diseases)\tresponse to rest involved in regulation of muscle adaptation (response to muscle inactivity involved in regulation of muscle adaptation)\tKORSAKOFF'S PSYCHOSIS (Vitamin related disorders)\tFACT-COG Version 3 - Able to Bring to Mind Words (Intellectual Product)", + "output": "KORSAKOFF'S PSYCHOSIS (Vitamin related disorders)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a targeted radioimmunoconjugate composed of a murine monoclonal anti-CD20 antibody (ibritumomab) linked by a chelator (tiuxetan) to the imaging radioisotope indium-111. This radioimmunoconjugate binds to CD20-positive cells, permitting radioimmuno-localization of CD20-positive cell biodistribution.\nConcepts: Decreased sialylation of N-linked protein glycosylation (Finding)\tReceptors, Fc (Amino Acid, Peptide, or Protein)\tzinc potentiation of glycinergic synaptic transmission (positive regulation of synaptic transmission, glycinergic)\tINDIUM IN-111 IBRITUMOMAB TIUXETAN (Radioimmunoconjugates)\tCSS1113A (Intellectual Product)", + "output": "INDIUM IN-111 IBRITUMOMAB TIUXETAN (Radioimmunoconjugates)" + }, + { + "input": "Definition: GAS6 gene described as human GAS6 wild-type allele is located in the vicinity of 13q34 and is approximately 44 kb in length. This allele, which encodes growth arrest-specific protein 6, plays a role in both ligand-mediated signaling and receptor tyrosine kinase binding.\nConcepts: Leukapheresis Units (Medical Device)\tperichromatin fibrils (cellular anatomical entity)\tFang Language (Language)\tFLJ34709 (GAS6 gene)\tcytoskeleton (Cellular Structures)", + "output": "FLJ34709 (GAS6 gene)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify deletions or duplications of the ribonucleotide reductase regulatory TP53 inducible subunit M2B (RRM2B) gene, located at chromosome 8q22.3, which encodes the protein ribonucleoside-diphosphate reductase subunit M2 B. Genetic variants at this locus have been associated with progressive external ophthalmoplegia with mitochondrial DNA deletions and mitochondrial DNA depletion syndrome.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, RRM2B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tDemethylating Agent (Antineoplastic Agents)\tresistance drug (Pharmacological Phenomena)\tMNSI105 (Intellectual Product)\tdownregulation of synapse structural plasticity (Organ or Tissue Function)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, RRM2B (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)" + }, + { + "input": "Definition: Lateral ventricle structure described as a surface feature of the medial wall of the lateral ventricle in the human. Defined on the basis of dissection it is the line of attachment of the tela choroidea of the lateral ventricle to the lateral surface of the fimbria ( Crosby-1962 ).\nConcepts: Millivolt Minute (Unit of Electricity and Magnetism)\tBromodomain (Amino Acid Sequence)\ttenia of the fimbria (Body Part, Organ, or Organ Component)\tMaxillary Sinus Cancer pTX TNM Finding v6 (Maxillary Sinus Cancer Pathologic Primary Tumor TNM Finding v6)\tBilateral polymicrogyria (Microgyria)", + "output": "tenia of the fimbria (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Bronchial Diseases described as sudden contraction of the smooth muscles of the bronchial wall that occurs during or following exercise.\nConcepts: Pars cardiaca gastricae (Zone of stomach)\tMesomelia (Limb structure)\tExercse ind bronchospasm (Other forms of asthma)\tregulation of adult somatic muscle development (Physiologic Function)\tCortical Cataract Grade 3 (Disease or Syndrome)", + "output": "Exercse ind bronchospasm (Other forms of asthma)" + }, + { + "input": "Definition: EORTC QLQ-C15-PAL Version 1 Questionnaire Question described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Palliative Care Version 1.0 - During the past week: Have you been constipated?\nConcepts: Cannulae, Eye, Cyclodialysis (Ophthalmic cannula)\tRADIOIMMUNOASSAY, IMMUNOREACTIVE INSULIN (Indicator, Reagent, or Diagnostic Aid)\tClinical Stage 0 Esophageal Squamous Cell Carcinoma AJCC v8 (Neoplastic Process)\t7-Chloro-1-(2-methylbenzoyl)-2,3-dihydroquinolin-4(1H)-one(E)-O-sulfooxime (Pharmacologic Substance)\tEOR02-Have You Been Constipated (Intellectual Product)", + "output": "EOR02-Have You Been Constipated (Intellectual Product)" + }, + { + "input": "Definition: Fibromatous neoplasm described as a morphologic variant of dermatofibrosarcoma protuberans characterized by the presence of melanin-pigmented dendritic cells.\nConcepts: Pigmented dermatofibrosarcoma protuberans of skin (Sarcoma of soft tissue)\tCoarsened hepatic echotexture (Abnormal liver sonography)\tGrade 2 Pancreatic enzymes decreased (Finding)\tEimeriids (Eimeriorina)\tCauda equina structure (CAUDA EQUINA AND FILUM)", + "output": "Pigmented dermatofibrosarcoma protuberans of skin (Sarcoma of soft tissue)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication described as molecular assay reagents intended to identify deletions or duplications of the activin A receptor type I (ACVR1) gene, located at chromosome 2q23-q24, which encodes the protein activin receptor type-1. Genetic variants at this locus have been associated with progressive myositis ossificans.\nConcepts: ERITREA (Geographic Area)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ACVR1 (Medical Device)\tC-SSRS Since Last Visit - Description of Interrupted Suicide Attempt (C-SSRS Since Last Visit Questionnaire Question)\tSpirillum minor (Spirillum)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, CBS (Medical Device)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ACVR1 (Medical Device)" + }, + { + "input": "Definition: Digestive System Part described as the lower third segment of the anal canal. It is covered with stratified squamous epithelium.\nConcepts: Polyglycolic Acid (Polyesters)\tGlutathione S-aryltransferase (Enzyme)\tSclerosing Funisitis (Funisitis)\tSITagliptin phosphate (Serine Proteinase Inhibitors)\tAnal Squamous Zone (Body Part, Organ, or Organ Component)", + "output": "Anal Squamous Zone (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Angiosperm described as a plant of the class MAGNOLIOPSIDA. It is a primitive group of mostly aquatic plants.\nConcepts: Arecholine (Cholinergic Agents)\tSpathiflorae (Plant)\tSolid pseudopapillary carcinoma of pancreas (Primary malignant neoplasm of pancreas)\tHodgkin's disease lymphocyte predominance type stage III (Neoplastic Process)\tpeptidyl-cysteine S-nitrosylase activity (transferase activity, transferring nitrogenous groups)", + "output": "Spathiflorae (Plant)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as autologous CD8 T-lymphocytes against melanoma-associated antigens, with potential immunomodulating and antineoplastic activities. Following leukapheresis and the ex vivo expansion of cytotoxic T-lymphocytes, the autologous CD8+ melanoma specific T-cells are re-introduced into the melanoma patient. These cytotoxic T-cells recognize and kill the patient's own melanoma cells.\nConcepts: Renal Pelvis and Ureter Cancer Clinical Distant Metastasis TNM Finding v7 (Renal Pelvis and Ureter Cancer Clinical TNM Finding v7)\tautologous melanoma-specific cytotoxic T lymphocytes (therapeutic autologous lymphocytes)\t(6R,7R,Z)-7-(2-(2-aminothiazol-4-yl)-2-(hydroxyimino)acetamido)-8-oxo-3-vinyl-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (Antibiotic)\tImmunoglobulin Kappa Light Chain Positive (Positive Laboratory Test Result)\tClinical Measurements (Health Care Activity)", + "output": "autologous melanoma-specific cytotoxic T lymphocytes (therapeutic autologous lymphocytes)" + }, + { + "input": "Definition: something described as a solid, semi-solid, solution or suspension designed to release active and/or inert ingredient(s) at a controlled rate.\nConcepts: Pneumococcal Polysaccharide Vaccine (Multivalent Vaccines)\tControlled Release Dose Form (Biomedical or Dental Material)\t3: 129777627-129773542 (Chromosome 3 Physical Location)\tregulation of type I interferon production (regulation of cytokine production)\tCeara (Geographic Area)", + "output": "Controlled Release Dose Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of segmented neutrophils compared to neutrophils present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Segmented Neutrophils to Neutrophils Ratio Measurement (Laboratory Procedure)\tGallbladder Benign Granular Cell Tumor (Benign neoplasm of gallbladder)\tMore Often than Once a Day (Schedule Frequency)\tCapsula nodi lymphoidei (lymph nodes)\tDeleterious SMARCA4 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Segmented Neutrophils to Neutrophils Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: mucilage metabolic process described as the chemical reactions and pathways involving mucilage that occur in the root cap; mucilage is normally synthesized during root growth.\nConcepts: root cap mucilage metabolic process (Molecular Function)\tstage IVA uterine corpus cancer (Neoplastic Process)\tERK inhibitor GDC-0994 (Serine/Threonine Kinase Inhibitor)\testablishment of plastid localisation (plastid localization)\tC19MC Amplification (Genetic finding)", + "output": "root cap mucilage metabolic process (Molecular Function)" + }, + { + "input": "Definition: Regimen Used to Treat Breast Carcinoma described as a chemotherapy regimen consisting of letrozole, leuprolide and palbociclib that can be used in the treatment of estrogen receptor (ER)-positive and HER-2/neu-negative metastatic or advanced breast cancer.\nConcepts: Genome Assembly (Molecular Sequence)\tTHERMOMETER, ELECTRONIC, CLINICAL (Thermometer, device)\tDocosenoic Acids (Fatty Acids, Monounsaturated)\tmacrophage chemotaxis (Chemotaxis, Leukocyte)\tLetrozole-Leuprolide-Palbociclib (Therapeutic or Preventive Procedure)", + "output": "Letrozole-Leuprolide-Palbociclib (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Quantitative Concept described as the upper limit of the laboratory test reference range, as reported in original units.\nConcepts: Aerobic Gram Negative Bacillus (Class Scotobacteria)\tSUMO E1 activator enzyme (ubiquitin-like modifier activating enzyme activity)\t6q21-q22.3 (Chromosome band)\t9: 123853443-123874996 (Chromosome 9 Physical Location)\tLBORNRHI (Quantitative Concept)", + "output": "LBORNRHI (Quantitative Concept)" + }, + { + "input": "Definition: Virus described as collection of single stranded RNA viruses scattered across the Bunyaviridae, Flaviviridae, and Togaviridae families whose common property is the ability to induce encephalitic conditions in infected hosts.\nConcepts: Chlorination (Metabolism)\tChristian Science support in-office 10 minutes (Therapeutic or Preventive Procedure)\tENCEPH VIRUS (RNA Viruses)\tanalyses survival (Statistics as Topic)\tHilar Cholangiocarcinoma TNM Finding v8 (Finding)", + "output": "ENCEPH VIRUS (RNA Viruses)" + }, + { + "input": "Definition: Angiogenesis Inhibitors described as a synthetic 14-amino acid peptide derived from a novel human peptide hormone, Tumor-Cells Apoptosis Factor (TCApF), with potential antineoplastic activity. Upon intravenous administration, tumor-cells apoptosis factor hormone-peptide binds to the T1/ST2 receptor (IL1RL1) and activates both caspase 8 and Bcl-2 mediated apoptosis, in addition to the activation of p38 MAPK and JNK signaling cascades in tumor cells. Furthermore, this agent inhibits angiogenesis by suppressing the expressions of vascular endothelial growth factor A (VEGFA) and fms-related tyrosine kinase 1 (VEGFR1). Tumor-cells apoptosis factor hormone-peptide also modulates immune system responses via increasing the expressions of interleukin-10 and anti-angiogenic interleukin. T1/ST2 receptor, a member of the toll/interleukin-1 receptor superfamily, is overexpressed in certain cancer cells.\nConcepts: Experiment End Date (End date)\tTumor-Cells Apoptosis Factor Hormone-Peptide (Angiogenesis Inhibitors)\tAW014921 (Gene or Genome)\tMonoclonal Antibody CAM 5.2 (Indicator, Reagent, or Diagnostic Aid)\tsunitinib (Organic Chemical)", + "output": "Tumor-Cells Apoptosis Factor Hormone-Peptide (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance.\nConcepts: HPD (Hematoporphyrins)\tGallbladder Cancer TNM Finding v6 (Digestive System Cancer TNM Finding v6)\tSynthetic Steroids (Therapeutic Hormone)\tglycan biosynthesis (polysaccharide metabolic process)\tnegative regulation of programmed cell clearance (negative regulation of phagocytosis)", + "output": "negative regulation of programmed cell clearance (negative regulation of phagocytosis)" + }, + { + "input": "Definition: Enemas for Constipation described as a synthetic pyridinylmethylene-diacetate ester derivative stimulant laxative, Bisacodyl acts with a parasympathetic effect directly on mucosal sensory nerves, increasing peristaltic contractions. It is used for occasional constipation, in pre- and postoperative treatment, and in conditions that require facilitation of defecation.\nConcepts: Assay, Viral Plaque (Virus Cultivation)\tBisacodyl-containing product (Contact laxatives)\ttransport of molecules into host (Cell Function)\tOral health (Actual Effective Body Tissue Integrity)\tTriggered by breast feeding (Triggered by)", + "output": "Bisacodyl-containing product (Contact laxatives)" + }, + { + "input": "Definition: Finding described as HIV mutation in the integrase (IN) coding region\nConcepts: positive regulation of aldosterone metabolism (positive regulation of small molecule metabolic process)\tEpithelium stratificatum cuboideum (Multilaminar epithelium)\tT124A (Finding)\tFocal motor aware seizure with dysarthria/anarthria (Disease or Syndrome)\tACHROMOBACTER XYLOSOXIDANS (Achromobacter)", + "output": "T124A (Finding)" + }, + { + "input": "Definition: Diagnostic Procedure described as biopsy of structures in the pelvis obtained by a needle inserted through the vaginal wall.\nConcepts: Ganglioglioma (Ganglioglioma)\tDissociative Fugue (Hysteria)\tGrade 4 Peripheral sensory neuropathy (Finding)\tTransvaginal Biopsy (Diagnostic Procedure)\tHypothyroidism, unspecified (Physical & Psychosomatic Disorders)", + "output": "Transvaginal Biopsy (Diagnostic Procedure)" + }, + { + "input": "Definition: Physiologic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of mitotic telomere clustering during interphase.\nConcepts: Enasidenib Mesylate (IDH2 inhibitor)\tcranial nerve II development (cranial nerve development)\tMycoplasma synoviae Olson et al. 1964 (Approved Lists 1980) emend. Jordan et al. 1982 (Mycoplasma)\tnegative regulation of interphase mitotic telomere clustering (regulation of interphase mitotic telomere clustering)\tGentiana scabra / long dan (Oriental herbs and natural substances letter G)", + "output": "negative regulation of interphase mitotic telomere clustering (regulation of interphase mitotic telomere clustering)" + }, + { + "input": "Definition: Heart rate and pulse investigations described as the pulsation of an artery where the pulse is taken (e.g. the radial artery at the wrist) cannot be detected on physical examination. []\nConcepts: RENAL SURGERY (Urologic Surgical Procedures)\tPULSELESS (Heart rate and pulse investigations)\tcynodon dactylon/doorba (Organic Chemical)\tStructure of internal iliac vein (Structure of tributary of common iliac vein)\tRelation, Interdepartmental (Social Behavior)", + "output": "PULSELESS (Heart rate and pulse investigations)" + }, + { + "input": "Definition: Genetic Function described as the process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group, in the mitochondrion.\nConcepts: SIQ0116 (SIQ Questionnaire Question)\tmitochondrial tRNA processing (mitochondrial RNA processing)\tRecommended Storage Atmospheric Pressure (Storage Condition)\tIVD Test Reagent/Kits, Serology, Rapid Test, Virus (Medical Device)\tenvenomation resulting in positive regulation of complement activation, alternative pathway in other organism (Biologic Function)", + "output": "mitochondrial tRNA processing (mitochondrial RNA processing)" + }, + { + "input": "Definition: Inorganic Chemical described as a formulation containing the compound copper chloride (CuCl2), that can potentially be used to enhance Cu levels in cancer cells in order to elevate the antitumor activity of chemotherapeutic agents that are dependent on Cu for their activity. Upon intravenous administration of CuCl2, the mineral Cu is selectively taken up by and accumulates in cancer cells. In the presence of certain chemotherapeutic agents whose mechanism of action (MoA) is dependent on Cu, this formulation may enhance their cytotoxic activity.\nConcepts: CuCl2 Formulation (Inorganic Chemical)\t5 Fluorouracilum (Pyrimidine analogues, antineoplastic antimetabolites)\tgrowth hormone receptor complex location (Cell Component)\tPeriodic Paralysis, Familial (Rare Non-Neoplastic Disorder)\tProto-Oncogene Protein c-maf (Biologically Active Substance)", + "output": "CuCl2 Formulation (Inorganic Chemical)" + }, + { + "input": "Definition: Subdivision of inferior systemic venous tree described as the veins which return blood from the kidneys to the vena cava.\nConcepts: renal vein (VENAE CAVAE AND TRIBUTARIES)\tLimit (Conceptual Entity)\tStructure of coronary ligament (Structure of ligament of liver)\tHAMD 24 - Depersonalization and Derealisation (Intellectual Product)\tPseudo Immunoglobulin Light Chain (Pre-B Cell Receptors)", + "output": "renal vein (VENAE CAVAE AND TRIBUTARIES)" + }, + { + "input": "Definition: something described as the directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.\nConcepts: MMS1-What is 100 Take Away 7 (Intellectual Product)\tSleep Apnea Syndromes (Cerebral disorder)\tfast endocytic recycling (endocytic recycling)\tdolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase activity (Molecular Function)\tKidney operation NOS (Kidney operation)", + "output": "fast endocytic recycling (endocytic recycling)" + }, + { + "input": "Definition: something described as sharply demarcated area of partial or complete depigmentation of the fundus reflecting atrophy of the retinal pigment epithelium with associated retinal photoreceptor loss. The margins of the de-pigmented area are usually scalloped and the large choroidal vessels are visible through the atrophic retinal pigment epithelium.\nConcepts: Macrophage Stimulating, Pseudogene 7 (Biologically Active Substance)\tClinical Primary Tumor TNM Finding (Finding)\tEstimated carbohydrate requirement in 24 hours (Carbohydrate requirement)\tAtrophy, Geographic (Atrophic retina)\tpTNM Finding (Finding)", + "output": "Atrophy, Geographic (Atrophic retina)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a human allotypic marker immunological test system is a device that consists of the reagents used to identify by immunochemical techniques the inherited human protein allotypic markers (such as nGm, nA2m, and Km allotypes) in serum and other body fluids. The identification may be used while studying population genetics.\nConcepts: Abnormal CSF biopterin level (Finding)\tregulation of neuromuscular synaptic transmission (Cell Function)\tNG1M(A), ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tProstate Cancer pT3a TNM Finding v6 (Finding)\tLung PEComa (Perivascular Epithelioid Cell Neoplasms)", + "output": "NG1M(A), ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as 1. The maintenance of a pool of neurons (e.g., premotor neurons, motor neurons or preganglionic sympathetic neurons in one or more segments of the spinal cord) in a state of partial or subthreshold excitation; in this state, less afferent stimulation is required to trigger the discharge of impulses. 2. A theory regarding the neurophysiological mechanisms underlying the neuronal activity associated with somatic dysfunction. 3. Facilitation may be due to sustained increase in afferent input, aberrant patterns of afferent input, or changes within the affected neurons themselves or their chemical environment. Once established, facilitation can be sustained by normal central nervous system (CNS) activity.\nConcepts: Facilitation, function (Organ or Tissue Function)\tBenzoxazinone (Organic Chemical)\tvindoline metabolic process (acetate ester metabolic process)\tZinc and Ring Finger 3 Gene Mutation (Cell or Molecular Dysfunction)\tmammotropic cell differentiation (Cell Differentiation process)", + "output": "Facilitation, function (Organ or Tissue Function)" + }, + { + "input": "Definition: protein-containing complex binding described as interacting selectively and non-covalently with the insulin receptor.\nConcepts: BPI Pain Interference Score 10 (Intellectual Product)\tSlow Virus Diseases (Virus Diseases)\tinsulin receptor binding (signaling receptor binding)\tCYP3A4*18 (CYP3A4 gene)\tMSTESTCD (Intellectual Product)", + "output": "insulin receptor binding (signaling receptor binding)" + }, + { + "input": "Definition: Classification described as any elsewhere undefined Oriental herb and natural substance, letter W, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Intracranial Benign Fibrous Histiocytoma (Histiocytoma, Benign Fibrous)\tUndefined Oriental herb and natural substance letter W narrative required (Classification)\tCSS0112 (Intellectual Product)\tAutoimmune Enteropathy (Gastrointestinal inflammatory disorders NEC)\tProkaryotes (Other Organism Groupings)", + "output": "Undefined Oriental herb and natural substance letter W narrative required (Classification)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory MCI (ADCS-ADL MCI) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: Arthus Phenomenon (Immunologic reaction)\tAlzheimer's Disease Cooperative Study-Activities of Daily Living Inventory MCI Version Questionnaire Test Name (CDISC Questionnaire Terminology)\tMOAB HuAFP31 (Monoclonal Antibodies)\tDeleterious ATV Gene Mutation (NBN Gene Mutation)\tstatistics (Research Activity)", + "output": "Alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory MCI Version Questionnaire Test Name (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Tumor Response Criterion described as response assessment criteria for the evaluation of patients undergoing immunotherapy for the treatment of malignant glioma. These recommendations integrate guidance for the determination and confirmation of tumor progression based on the response assessment in neuro-oncology (RANO) working group and the immune-related response criteria (irRC).\nConcepts: Compartment Region (regional)\tadhesive extracellular matrix (Extracellular Matrix)\tImmunotherapy Response Assessment in Neuro-Oncology Criteria (Intellectual Product)\tBracket epiphysis of the proximal phalanx of the hallux (Bracket epiphyses of the hallux)\tDRRI1-K: Uncooperative Working With Me (Intellectual Product)", + "output": "Immunotherapy Response Assessment in Neuro-Oncology Criteria (Intellectual Product)" + }, + { + "input": "Definition: something described as an enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine.\nConcepts: QS (Cell Communication)\tup-regulation of glycolysis (positive regulation of purine nucleotide metabolic process)\tPlacental Malformation (Disease or Syndrome)\tribosomal-protein-alanine N-acetyltransferase complex location (protein acetyltransferase complex)\tregulation of amino acid transport (regulation of organic acid transport)", + "output": "ribosomal-protein-alanine N-acetyltransferase complex location (protein acetyltransferase complex)" + }, + { + "input": "Definition: Organ or Tissue Function described as any process that modulates the frequency, rate or extent of renin secretion into blood stream.\nConcepts: Gram per Hour (SI units of mass per unit time)\tDecreased natural antibody to blood group agents (Finding)\tLuminometers (Medical Device)\tProprietary Method (Intellectual Product)\tregulation of renin secretion into blood stream (regulation of cell communication)", + "output": "regulation of renin secretion into blood stream (regulation of cell communication)" + }, + { + "input": "Definition: Inflammatory disorder described as inflammation of the mucous membranes.\nConcepts: Concentrate for Concentrate for Solution for Infusion Dosage Form (Concentrated Solution Dosage Form)\tGrade 4 Personality change (Personality Change, CTCAE)\tGrade 1 Dehydration, CTCAE (Dehydration, CTCAE)\tMental retardation, X-linked 14 (Disease or Syndrome)\tMUCOSAL INFLAMMATION (Mucosal findings abnormal)", + "output": "MUCOSAL INFLAMMATION (Mucosal findings abnormal)" + }, + { + "input": "Definition: Antineoplastic Immune Cell described as human autologous mesenchymal stem cells (MSCs) harvested from the bone marrow of a patient and genetically modified with a self-inactivating retroviral vector expressing the suicide gene herpes simplex virus thymidine kinase (HSV-TK), that can be used to activate synthetic acyclic guanosine analogues when co-administered. Upon intravenous administration of autologous mesenchymal stem cells apceth_101, the cells are actively recruited to the tumor stroma, differentiate into more mature mesenchymal cells, and become part of the tumor microenvironment. When a synthetic acyclic guanosine analogue, such as ganciclovir, is co-administered, the HSV-TK within the HSV-TK-transduced MSCs will monophosphorylate this prodrug. Subsequently the monophosphate form is further converted to the diphosphate form and then to its active triphosphate form by cellular kinases. The active form of ganciclovir kills the HSV-TK-transduced MSCs and leads to a bystander effect, which eliminates neighboring cancer cells. Therefore, synthetic acyclic guanosine analogues are activated only at the tumor site, which increases their local efficacy and reduces systemic toxicity.\nConcepts: Histone H1b (Biologically Active Substance)\tHuman Centered Designs (Idea or Concept)\tautologous MSC apceth 101 (Antineoplastic Immune Cell)\tEarly Myoclonic Encephalopathy (Myoclonic disorder)\tCurettes, Surgical, Bone, Spinal, Disc (Medical Device)", + "output": "autologous MSC apceth 101 (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as mobile, self-contained, self-sufficient health care facilities capable of rapid deployment and expansion or contraction to meet immediate emergency requirements for a specified period of time.\nConcepts: negative regulation of brassinosteroid biosynthetic process (Cell Function)\tKRIT1 ankyrin repeat containing (Gene Mutation)\tEarly balding (Finding)\tInhalation vapour, capsule (Biomedical or Dental Material)\tField Hospitals (Manufactured Object)", + "output": "Field Hospitals (Manufactured Object)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a substance that is being studied in the treatment of cancer. It is made by combining the monoclonal antibody CC49 with a chemical called streptavidin. It can find tumor cells that have the protein TAG-72 on their surface, including colon, prostate, breast, and ovary cancer cells. After CC49-streptavidin binds to cancer cells, a radioactive compound called yttrium Y 90 DOTA-biotin will find those cells and kill them.\nConcepts: anti-TAG-72 monoclonal antibody CC49-streptavidin conjugate (Immunoconjugates)\tAntibacterial Pouches, Cardiovascular Implantable Electronic Devices (Mesh Pouches, Pacemaker/Defibrillator)\tRAB23 (Gene or Genome)\tLaryngoscope Blades (Medical Device)\tFAC07138 (FACIT-F Version 4 Questionnaire Question)", + "output": "anti-TAG-72 monoclonal antibody CC49-streptavidin conjugate (Immunoconjugates)" + }, + { + "input": "Definition: something described as autosomal recessive neuroectodermal disorders characterized by brittle sulfur-deficient hair associated with impaired intellect, decreased fertility, and short stature. It may include nail dystrophy, ICHTHYOSIS, and photosensitivity correlated with a NUCLEOTIDE EXCISION REPAIR defect. All individuals with this disorder have a deficiency of cysteine-rich KERATIN-ASSOCIATED PROTEINS found in the interfilamentous matrix. Photosensitive trichothiodystrophy can be caused by mutation in at least 2 separate genes: ERCC2 PROTEIN gene and the related ERCC3. Nonphotosensitive trichothiodystrophy can be caused by mutation in the TTDN1 gene.\nConcepts: Human herpesvirus 6 infc (Disease due to Betaherpesvirinae)\tCasework (Casework and Furniture)\tPROSTATIC RUDIMENT (Embryonic Structure)\tMale Castration (Procedure on testis)\tTrichothiodystrophy Syndrome (Autosomal recessive hereditary disorder)", + "output": "Trichothiodystrophy Syndrome (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: positive regulation of multicellular organismal process described as any process that activates or increases the frequency, rate or extent of animal organ morphogenesis.\nConcepts: cellular response to bile acid (cellular response to oxygen-containing compound)\tpositive regulation of animal organ morphogenesis (regulation of animal organ morphogenesis)\tmalonic acid import into cell (Import into cell)\tTrephines, Dental, Implant Removal (Trephines, Dental)\tBacillus hydrophilus (Aeromonas)", + "output": "positive regulation of animal organ morphogenesis (regulation of animal organ morphogenesis)" + }, + { + "input": "Definition: Biologically Active Substance described as a family of muscle-specific transcription factors which bind to DNA in control regions and thus regulate myogenesis. All members of this family contain a conserved helix-loop-helix motif which is homologous to the myc family proteins. These factors are only found in skeletal muscle. Members include the myoD protein (MYOD PROTEIN); MYOGENIN; myf-5, and myf-6 (also called MRF4 or herculin).\nConcepts: histone lysine N-acetyltransferase activity (Molecular Function)\timmune system (Hemic and Immune Systems)\t5' transitive RNA interference (Genetic Function)\tMyogenic Regulatory Factors (Biologically Active Substance)\tgadoxetic acid, disodium (G [Preparations])", + "output": "Myogenic Regulatory Factors (Biologically Active Substance)" + }, + { + "input": "Definition: Neoplastic Process described as a rare hepatic and biliary tract tumour, arising either in the gallbladder itself or in the epithelium lining the extrahepatic biliary tree, the cystic duct and peribiliary glands. It is characterised by a substantial keratinisation with abundant keratohyalin pearls and central deposition of dense keratin material within infiltrative nests and locally aggressive nature. In the early stages of the disease symptoms are vague and nonspecific (abdominal pain, jaundice and vomiting). In the advanced stages it may present with a bulky tumour and symptoms of adjacent organ involvement.\nConcepts: frontal association cortex (Body Part, Organ, or Organ Component)\tferric leghemoglobin reductase activity (oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MLC1 (Medical Device)\tSt. Kitts-Nevis (Geographic Area)\tSquamous cell carcinoma of gallbladder and extrahepatic biliary tract (Neoplastic Process)", + "output": "Squamous cell carcinoma of gallbladder and extrahepatic biliary tract (Neoplastic Process)" + }, + { + "input": "Definition: Cell Component described as a heterodimeric protein complex of protein C inhibitor (SERPINA5) and acrosin; formation of the complex inhibits the protease activity of acrosin.\nConcepts: Childhood Choriocarcinoma of the Ovary (Childhood Choriocarcinoma)\t5-{1-Hydroxy-2-[2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-benzene-1,3-diol (metaproterenol)\tBcr-Abl (b2a2) Derived Peptide Vaccine (BCR-ABL Peptide Vaccine)\tmesencephalic tegmentum (Cerebral Peduncle)\tprotein C inhibitor-acrosin complex location (serine protease inhibitor complex)", + "output": "protein C inhibitor-acrosin complex location (serine protease inhibitor complex)" + }, + { + "input": "Definition: Lymphocyte antigen described as also known as CD104 antigen, this protein is distinguished from other beta integrins by its relatively long cytoplasmic domain (approximately 1000 amino acids vs. approximately 50). Five alternatively spliced isoforms have been described.\nConcepts: beta4 Integrin (Integrin beta Chains)\tLugano Classification Stage IV Childhood Hodgkin Lymphoma AJCC v8 (Lugano Classification Stage IV Hodgkin Lymphoma AJCC v8)\tcancer detection, early (Health Care Activity)\tArsenic compound (Organic Chemicals)\tNecrotizing Enterocolitis, AE (Neonatal Adverse Event)", + "output": "beta4 Integrin (Integrin beta Chains)" + }, + { + "input": "Definition: Pharmacologic Substance described as a steroidal alkylating agent with potential antineoplastic activity. Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA replication and cell division. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2707\" active clinical trials using this agent.\nConcepts: Hirudins (Anticoagulants)\tRadial deviation of the ring finger (Deviation of the 4th finger)\tDHEA Mustard (Organic Chemical)\tCD8+NKG2D+ AKT cells (Antineoplastic Immune Cell)\tOral Microbiota (Microbiome)", + "output": "DHEA Mustard (Organic Chemical)" + }, + { + "input": "Definition: Working Breed described as a watchful, intimidating guardian dog who is sweetly devoted to family and aloof and territorial with strangers. They have a double coat with fairly long thick, coarse guard hair and a heavy soft undercoat. The colors are black, brown, and blue/grey without markings. The height is a minimum 24 inches and the average weight range is 70-150 pounds.\nConcepts: DEAE-Cellulose (cellulose)\tWater Content Determination (Research Activities)\tMyeloid Translocation Gene On Chromosome 16 Protein (Transcription Regulatory Protein)\taMIL (Antineoplastic Immune Cell)\tTibetan Mastiff (Working Breed)", + "output": "Tibetan Mastiff (Working Breed)" + }, + { + "input": "Definition: regulation of granulocyte colony-stimulating factor production described as any process that stops, prevents, or reduces the frequency, rate, or extent of production of granulocyte colony stimulating factor.\nConcepts: Pulse, allorhythmic (Cardiovascular finding)\tINTRACRANIAL (Parenteral Route of Drug Administration)\tIVD Test Reagent/Kits, Serology, Bacteria, Streptococcus A, Antibody, Hyaluronidase (IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus Species, Antibody)\tnegative regulation of colony stimulating factor 3 (granulocyte) production (negative regulation of macrophage colony-stimulating factor production)\tStage IIA Merkel Cell Carcinoma AJCC v7 (Neoplastic Process)", + "output": "negative regulation of colony stimulating factor 3 (granulocyte) production (negative regulation of macrophage colony-stimulating factor production)" + }, + { + "input": "Definition: something described as the process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms.\nConcepts: A498 (Experimental Model of Disease)\tMalignant nipple neoplasm female (Neoplastic Process)\tFETUS (Tissue)\tSonepcizumab (Amino Acid, Peptide, or Protein)\ttemperature compensation of the circadian clock (regulation of circadian rhythm)", + "output": "temperature compensation of the circadian clock (regulation of circadian rhythm)" + }, + { + "input": "Definition: Dysplasia with increased bone density described as an autosomal dominant or recessive form of craniotubular hyperostosis due to mutation(s) in the SOST gene, encoding sclerostin. This condition is characterized by massive generalized hyperostosis and sclerosis, especially involving the skull and facial bones, which is so severe that the resulting facial distortion is referred to as 'leontiasis ossea'; the bone deposition results in progressive stenosis of craniofacial foramina and can lead to severe neurologic impairment in childhood.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Toxicology (Medical Device)\tblood coagulation, fibrin clot formation (protein activation cascade)\tCDD (Dysplasia with increased bone density)\tCreation of duodenostomy (Repair of duodenum)\tCutaneous Carcinoma TNM Finding v7 (Finding)", + "output": "CDD (Dysplasia with increased bone density)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving UTP, uridine (5'-)triphosphate.\nConcepts: Loss (of);hair (Level of stress)\tUTP metabolic process (Molecular Function)\tJuberg Hayward syndrome (Disease or Syndrome)\tregulation of humoral immune response (regulation of immune response)\tCommunication, Scholarly (Intellectual Product)", + "output": "UTP metabolic process (Molecular Function)" + }, + { + "input": "Definition: Autosomal hereditary disorder described as a rare genetic endocrine growth disease resulting from growth hormone secretagogue receptor (GHSR) deficiency. The disease has characteristics of postnatal growth delay that results in short stature. The pituitary gland is typically without morphological changes, although anterior pituitary gland hypoplasia has been reported.\nConcepts: Polycyclic aromatic hydrocarbons (Polycyclic Compounds)\tShort stature due to growth hormone secretagogue receptor deficiency (Autosomal hereditary disorder)\tGrowth suppression (Growth Disorders NEC)\tPedsQL Neuromuscular Module Version 3.0 Young Child Report - Get Sick Easily (PedsQL Neuromuscular Module Version 3.0 Young Child Report Questionnaire Question)\tWalker (Finding)", + "output": "Short stature due to growth hormone secretagogue receptor deficiency (Autosomal hereditary disorder)" + }, + { + "input": "Definition: something described as treatment with injections of therapeutic substances linked with specific antibodies in order to directly destroy specific, usually cancerous, cells or to stimulate the immune system to destroy those cells.\nConcepts: Wedge shaped cranium (Congenital abnormal shape of frontal bone)\tAcid phos (Clinical Enzyme Tests)\tAspartate, Potassium Magnesium (Potassium Compounds)\tShort middle phalanx of toe (Anatomical Abnormality)\ttherapy, antibody-drug conjugate (Immunotherapy)", + "output": "therapy, antibody-drug conjugate (Immunotherapy)" + }, + { + "input": "Definition: something described as a fusion protein encoded by the CBFB/MYH11 fusion gene. This protein is comprised of most of the core-binding factor subunit beta fused to the C-terminal dimerization domain of myosin-11.\nConcepts: Antineoplastic Biological Agent (Antineoplastic Agents)\tRNA polymerase I complex (nuclear DNA-directed RNA polymerase complex)\t12q24.1 (Cell Component)\tCBFbeta-MYH11 fusion protein (Amino Acid, Peptide, or Protein)\tWaldenstrom's macroglobulinaemia (Neoplastic Process)", + "output": "CBFbeta-MYH11 fusion protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: amino acid import across plasma membrane described as the directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol.\nConcepts: How much of the time did you have pain (Clinical or Research Assessment Question)\tInferior segment of hair follicle (Region of hair follicle)\tEC 2.4.1.17 (Enzyme)\tL-ornithine import into cell (Cell Function)\tWeak Opioids (Finding)", + "output": "L-ornithine import into cell (Cell Function)" + }, + { + "input": "Definition: Meninges described as having to do with the two innermost meninges (thin layers of tissue that cover and protect the brain and spinal cord).\nConcepts: regulation of antifungal peptide biosynthetic process (regulation of antifungal peptide production)\thistone H3 arginine 26 citrullination (Molecular Function)\tLEPTOMENINGES (Meninges)\tDNA replication-dependent nucleosome disassembly (DNA replication-dependent nucleosome organization)\tNonabsorbable Periodontal Regeneration Membrane Implants (Dental Materials)", + "output": "LEPTOMENINGES (Meninges)" + }, + { + "input": "Definition: Pharmacologic Substance described as a recombinant type 5 adenovirus (Ad5), encoding the gene for the human sodium-iodide symporter (NIS) linked to the cytomegalovirus (CMV) promoter, with potential gene transfection activity. Upon intratumoral injection, Ad5-CMV-NIS is taken up by tumor cells, resulting in the cellular expression of NIS. Subsequently, orally administered iodine 131 is taken up by NIS-expressing tumor cells, which may result in the selective accumulation of a cytotoxic dose of beta and gamma radiation in non-thyroidal tumor cells, sparing adjacent normal tissue. NIS, an intrinsic membrane glycoprotein, is an ion pump that actively transports iodide into cells which concentrate iodine; in addition to thyroid epithelial cells, it is found in non-thyroidal tissues including the salivary glands, the gastric mucosa, and lactating mammary glands.\nConcepts: area FF of Bonin (Body Location or Region)\t1: 65064007-65012229 (Spatial Concept)\tUrinary Leakage (Body Fluid Leakage)\tPharmaceutical Quality/Chemistry, Manufacturing, and Controls Storage Conditions Terminology (Unused Subset Concept)\trecombinant type 5 adenovirus carrying the human NIS gene linked to the CMV promotor (Pharmacologic Substance)", + "output": "recombinant type 5 adenovirus carrying the human NIS gene linked to the CMV promotor (Pharmacologic Substance)" + }, + { + "input": "Definition: Abnormality of the tonsils described as any abnormality of nasopharyngeal adenoids. []\nConcepts: Stage IVB Carcinoma of Oropharynx (Stage IVB Pharyngeal Carcinoma)\tNeurotrophic Factor (Biologically Active Substance)\tAbnormality of nasopharyngeal tonsil (Abnormality of the nasopharynx)\tPharmacologic Agent (Drug, Food, Chemical or Biomedical Material)\tSepta (Medical Device)", + "output": "Abnormality of nasopharyngeal tonsil (Abnormality of the nasopharynx)" + }, + { + "input": "Definition: Myeloid Leukemia, Chronic described as myelogenous leukemia that is negative for Philadelphia chromosome.\nConcepts: Myeloid leukemia, subacute (Primary malignant neoplasm)\tCompensatory head tilt/chin elevation (Finding)\tDid you have weakness on one side of your body (Clinical or Research Assessment Question)\tCDR0101 (Intellectual Product)\tthiamine oxidase activity (Molecular Function)", + "output": "Myeloid leukemia, subacute (Primary malignant neoplasm)" + }, + { + "input": "Definition: something described as substantial narrowing or blockage of small pulmonary veins as a result of disorganized smooth muscle hypertrophy and collagen matrix deposition.\nConcepts: CATARACT, ANTERIOR POLAR, 1 (Polar cataract)\tpositive regulation of natural killer cell tolerance induction (positive regulation of tolerance induction)\tPulmonary venous stenosis (Abnormal pulmonary vein morphology)\tHuman Immunodeficiency Virus Unknown (CPTAC Responses)\tLiver Cancer pM1 TNM Finding v7 (Finding)", + "output": "Pulmonary venous stenosis (Abnormal pulmonary vein morphology)" + }, + { + "input": "Definition: Spatial Concept described as a position, site, or point on the body where electrocardiogram leads are attached.\nConcepts: Failure to Fire (Finding)\tRoseomonas mucosa (Roseomonas)\tcellular response to interleukin-12 (cellular response to cytokine stimulus)\tEGLOC (Spatial Concept)\tTear film insufficiency, unspecified (Other disorders of lacrimal gland)", + "output": "EGLOC (Spatial Concept)" + }, + { + "input": "Definition: response to ciliary neurotrophic factor described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ciliary neurotrophic factor stimulus.\nConcepts: fluorine F 18 galacto-RGD peptide (Radioconjugate)\tGastric Neuroendocrine Tumor TNM Finding v8 (Digestive System Neuroendocrine Tumor TNM Finding v8)\tCDISC Questionnaire MPAI-4 Test Code Terminology (CDISC Questionnaire Terminology)\tcellular response to ciliary neurotrophic factor (response to ciliary neurotrophic factor)\tPlace (Activity)", + "output": "cellular response to ciliary neurotrophic factor (response to ciliary neurotrophic factor)" + }, + { + "input": "Definition: Yeast Proteins described as nuclear Swi3p is an 825-aa, 93-kD general RNA polymerase II transcription factor component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Swi3p contains a MYB-like domain and interacts with the N-terminus of SNF2.\nConcepts: SOAPP-R Questionnaire Question (Clinical or Research Assessment Question)\tTumor Necrosis Factor (Pharmacologic Substance)\tTranscription Regulatory Protein Swi3 (Amino Acid, Peptide, or Protein)\tUterine Corpus Adenosarcoma pN0 TNM Finding v8 (Uterine Corpus Adenosarcoma Pathologic Regional Lymph Nodes TNM Finding v8)\tStructure of medial olfactory striae (Rhinencephalon structure)", + "output": "Transcription Regulatory Protein Swi3 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: wheelchair described as wheelchairs that are user propelled and/or attendant operated (i.e., nonpowered, mechanical, manually-operated).\nConcepts: Manual wheelchair (wheelchair)\tBroad lower face (Face)\tLangerhans cell sarcoma (Sarcoma)\tDecreased Cellularity Present (Low Cellularity Present)\tUrease Measurement (Laboratory Procedure)", + "output": "Manual wheelchair (wheelchair)" + }, + { + "input": "Definition: Organic Chemical described as the sodium salt form of ceftezole, a semi-synthetic first-generation cephalosporin with antibacterial activity.\nConcepts: Ceftezole Sodium (Antibiotic)\tStage IV Childhood Non-Hodgkin Lymphoma (Stage IV Non-Hodgkin Lymphoma)\tPQL04-Hard to Breathe (PedsQL Neuromuscular Module Version 3.0 Parent Report for Teen Questionnaire Question)\tCocrystallography (Research Activity)\tRUNDC2A (Gene or Genome)", + "output": "Ceftezole Sodium (Antibiotic)" + }, + { + "input": "Definition: Mental Processes described as the knowledge or perception that someone or something present has been previously encountered.\nConcepts: PerformedGeneticObservationResult.geneticRegionTypeCode (Intellectual Product)\tPsychology Recognition (Mental Recall)\tToe Interphalangeal Joint (Interphalangeal joint structure)\tExpression by IHC (Laboratory Procedure)\tinv(22q12) (Chromosome inversion)", + "output": "Psychology Recognition (Mental Recall)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.\nConcepts: acetylcholine transmembrane transporter activity (acetate ester transmembrane transporter activity)\tAnaplastic Lymphoma Receptor Tyrosine Kinase Gene Translocation (Chromosomal translocation)\tAtorvastatin Calcium Anhydrous (Organic Chemical)\tBroad xiphoid process (Finding)\tAnti-Anxiety Agents (Anti-Anxiety Agents)", + "output": "acetylcholine transmembrane transporter activity (acetate ester transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a measurement of the free lambda light chain in a biological specimen.\nConcepts: Amalgams, Dental (metal dental material)\tobjective (Study Objective)\tLLCFR (Laboratory Procedure)\tOrthopedic chisel (Chisels, Surgical)\tIVD Panels, Human Genetics, Mitochondrial Disorder, Encephalopathy, Comprehensive, Del/Dup (IVD Panels, Human Genetics, Mitochondrial Disorder, Encephalopathy)", + "output": "LLCFR (Laboratory Procedure)" + }, + { + "input": "Definition: MARK2 gene described as human MARK2 wild-type allele is located in the vicinity of 11q13.1 and is approximately 72 kb in length. This allele, which encodes serine/threonine-protein kinase MARK2 protein, is involved in both protein phosphorylation and microtubule dynamics.\nConcepts: Planum temporale (Body Part, Organ, or Organ Component)\tIPA01-Total Vigorous Hours per Week (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tMenotropin preparation (Pituitary hormone preparation)\tPar1b (MARK2 gene)\tubiquitin-protein transferase activator activity (Molecular Function)", + "output": "Par1b (MARK2 gene)" + }, + { + "input": "Definition: Merkel Cell Carcinoma by AJCC v7 Stage described as stage III Merkel cell cancer is divided into stages IIIA and IIIB. In stage IIIA, the tumor may be any size and may have spread to nearby bone, muscle, connective tissue, or cartilage. Cancer is found in the lymph nodes when they are checked under a microscope. In stage IIIB, the tumor may be any size and may have spread to nearby bone, muscle, connective tissue, or cartilage. Cancer has spread to the lymph nodes near the tumor and is found by physical exam or imaging test. The lymph nodes are removed and cancer is found in the lymph nodes when they are checked under a microscope. There may also be a second tumor, which is either between the primary tumor and nearby lymph nodes or farther away from the center of the body than the primary tumor is.\nConcepts: Infections, Hepadnaviridae (Disease or Syndrome)\tStage III Merkel Cell Carcinoma (Neoplastic Process)\tN 6 Fatty Acid (Biologically Active Substance)\tSwimming (Physical activity)\tSS18 subunit of BAF chromatin remodeling complex (Transcription Regulation Gene)", + "output": "Stage III Merkel Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a nucleotide substitution at position 601 of the coding sequence of the GNAS gene where cytosine has been mutated to adenine.\nConcepts: Abnormality of the tonsils (Anatomical Abnormality)\tGNAS1 c.601C>A (GNAS Gene Mutation)\tADNI AVLT - List A Recall 5 Word 4 (Intellectual Product)\tSandifer's Syndrome (Chronic digestive system disorder)\tVas deferens structure (Prostate and vas deferens structures)", + "output": "GNAS1 c.601C>A (GNAS Gene Mutation)" + }, + { + "input": "Definition: something described as high risk chronic myelomonocytic leukemia that does not respond to treatment.\nConcepts: Grade 4 Vitreous Hemorrhage, CTCAE (Vitreous Hemorrhage, CTCAE 5.0)\tBOTULINUM NEUROTOXIN A4 (Pharmacologic Substance)\tRefractory High Risk Chronic Myelomonocytic Leukemia (High Risk Chronic Myelomonocytic Leukemia)\tER to Golgi vesicle-mediated transport (Cell Function)\tHuman-Device Interface Problem (Event)", + "output": "Refractory High Risk Chronic Myelomonocytic Leukemia (High Risk Chronic Myelomonocytic Leukemia)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving tyrocidine.\nConcepts: Antigen, CD66e (Immunoglobulin Family Protein)\ttyrocidine metabolism (Molecular Function)\tCYP2C8 Inducers (Pharmacologic Substance)\tdesipramine HCl (Tricyclic Antidepressive Agents)\tAstatine 211-Labeled Anti-CD45 Monoclonal Antibody BC8-B10 (Radioimmunoconjugates)", + "output": "tyrocidine metabolism (Molecular Function)" + }, + { + "input": "Definition: Research Device described as a spectrometer that applies some form of energy to a substance, thereby causing emission of electromagnetic radiation which is then quantified using a detector.\nConcepts: Emission Spectrometer (Research Device)\tPainting, Interior or Exterior (Intellectual Product)\tMITRAL VALVE, ANTERIOR ANNULUS (Body Part, Organ, or Organ Component)\tFAD or FADH2 binding (anion binding)\tCHEM ENGINEERING (Occupation or Discipline)", + "output": "Emission Spectrometer (Research Device)" + }, + { + "input": "Definition: Pharmacologic Substance described as nosode of diphtheria.\nConcepts: 3-geranylgeranylindole NADPH:oxygen oxidoreductase (10,11-epoxidizing) activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tNID1 Gene (Extracellular Matrix Protein Gene)\tMCF3 Fusion Negative (Expression Negative)\tDiphtherinum / diphtheria nosode (Homeopathic remedies letter D)\tSoft Tissue Method (Direct Method)", + "output": "Diphtherinum / diphtheria nosode (Homeopathic remedies letter D)" + }, + { + "input": "Definition: Antivirals for treatment of HIV infections, combinations described as a fixed combination of darunavir, an inhibitor of the human immunodeficiency virus (HIV) protease; and cobicistat, a cytochrome P450 3A (CYP3A) inhibitor that may be used to treat HIV infection. Upon oral administration, darunavir binds to and inhibits the dimerization and catalytic activity of the HIV aspartyl protease. This inhibits the cleavage of HIV-encoded Gag and Gag-Pol polyproteins in virus-infected cells, which prevents the formation of mature infectious virions. Cobicistat inhibits CYP3A, thereby limiting the metabolism of darunavir and increases its systemic exposure.\nConcepts: Capsular Contracture (Finding)\tMitotic Rate (Mitosis)\tBACILLUS SUBTLIS, MICROBIOLOGICAL ASSAY, GENTAMICIN (Indicator, Reagent, or Diagnostic Aid)\tMoraxella liquefaciens (Moraxella )\tCobicistat and darunavir product (Anti-HIV Agents, Protease Inhibitors)", + "output": "Cobicistat and darunavir product (Anti-HIV Agents, Protease Inhibitors)" + }, + { + "input": "Definition: Mental Process described as learning to combine words into phrases.\nConcepts: Height Measuring Instruments (Medical Device)\tStage III Differentiated Thyroid Gland Cancer (Differentiated Thyroid Gland Carcinoma by AJCC v8 Stage)\tAspilia Thouars (Heliantheae)\tCombining words into phrases (Acquiring language)\tQS-FACT-LEU Version 4 TEST (Intellectual Product)", + "output": "Combining words into phrases (Acquiring language)" + }, + { + "input": "Definition: something described as nasal cavity and paranasal sinuses cancer in which the regional lymph nodes cannot be assessed.\nConcepts: Subphylum Crustacea (Arthropods)\tlog10 CCID 50/dose (Unit of Arbitrary Substance Concentration)\tNasal Cavity and Paranasal Sinuses Carcinoma cNX TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Clinical Regional Lymph Nodes TNM Finding v8)\tPrinters, Label (Printer/plotter)\tepilepsy; absence (Absence Seizures)", + "output": "Nasal Cavity and Paranasal Sinuses Carcinoma cNX TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Clinical Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: Functional Concept described as aspartate and asparagine are catabolized into oxaloacetate and the Kreb's cycle in a fairly direct pathway for amino acids with four carbons. The first step for asparagine catabolism is hydrolysis by the enzyme asparaginase, releasing aspartate and ammonia. Aspartate is then transaminated by aspartate transaminase to exchange its amino group onto alpha-ketoglutarate and be converted into oxaloacetate. As part of the Kreb's cycle, the carbon skeleton of oxaloacetate can generate energy and provide material for biosynthesis. The enzyme asparaginase is used as a cancer treatment through injection. Some cancers such as leukemias are highly dependent on asparagine circulating in the blood that comes from the diet. The required asparagine helps to support the rapid growth of malignant cells. Injection of asparaginase metabolizes the asparagine in the blood, withdrawing the supply of this essential nutrient from tumor cells, and causing asparagine-dependent tumor cells to die. Normal cells provide enough asparagine for their own needs through biosynthesis and are affected to a lesser extent by this treatment.\nConcepts: Catabolic Pathway for Asparagine and Aspartate (Amino Acid Metabolism Pathway)\tSLAM-Associated Protein (Amino Acid, Peptide, or Protein)\thematinics iron sucrose (Iron-containing product in oral dose form)\t1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone (pyrimidine analog)\tSEND-STRPSTAT (Intellectual Product)", + "output": "Catabolic Pathway for Asparagine and Aspartate (Amino Acid Metabolism Pathway)" + }, + { + "input": "Definition: Disease or Syndrome described as life-threatening anemia associated with a high risk of infection or bleeding. Historically defined as bone marrow (BM) cellularity <25% (or <50% if <30% of BM is hematopoietic cells), and two or more of the following: absolute neutrophil count of <500; platelet count of <20,000; or a corrected reticulocyte count of <1%. Absence of cytogenetic abnormalities associated with myelodysplastic syndrome or malignancy must be ruled out prior to diagnosis.\nConcepts: esperamicin A1 (Pharmacologic Substance)\tFood And Water (Idea or Concept)\tPitch (Hearing)\tSevere Aplastic Anemia (Aplastic Anemia)\tSaddle nose, NOS (Form of nose)", + "output": "Severe Aplastic Anemia (Aplastic Anemia)" + }, + { + "input": "Definition: ethylene urea described as a hydantoin derivative and direct-acting skeletal muscle relaxant. Dantrolene depresses excitation-contraction coupling in skeletal muscle by binding to the ryanodine receptor 1, and decreasing intracellular calcium concentration. Ryanodine receptors mediate the release of calcium from the sarcoplasmic reticulum, an essential step in muscle contraction.\nConcepts: 1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin (skeletal muscle relaxants)\tGrade 2 Hemoglobin increased (Finding)\tStructure of tentorium cerebelli (Anatomical feature)\tBulbar urethral stricture (Urethral stricture)\tkeratin 8, human (Amino Acid, Peptide, or Protein)", + "output": "1-((5-(p-nitrophenyl)furfurylidene)amino)hydantoin (skeletal muscle relaxants)" + }, + { + "input": "Definition: DNA Repair Gene described as this gene is involved in cellular repair and apoptosis.\nConcepts: Ovalocytosis, Hereditary (Hereditary Diseases)\tTechnician, Animal Care (Veterinary technician)\tpoly (ADP-ribose) polymerase family, member 1 (DNA Repair Gene)\tGrade 3 Duodenal Fistula, CTCAE (Finding)\tFeel Like Have to Strain to Produce Voice (Clinical or Research Assessment Question)", + "output": "poly (ADP-ribose) polymerase family, member 1 (DNA Repair Gene)" + }, + { + "input": "Definition: something described as a nutritional supplement composed of an aqueous extract derived from the leaves of the tropical fern belonging to the Polypodiaceae family, Polypodium leucotomos (PL; Phlebodium aureum), with potential photoprotective, skin protective, anti-inflammatory, immunomodulating and antioxidant activities. This extract contains many phenolic compounds, such as ferulic, caffeic, coumaric and vanillic acid, which are mainly responsible for this extract's effects. Upon administration, Polypodium leucotomos extract (PLE) exerts antioxidant activity by scavenging free radicals and inhibiting the generation and release of reactive oxygen species (ROS), thereby preventing ultraviolet (UV)-induced as well as ROS-induced DNA damage. In addition, the chemicals in this extract protect antioxidant enzymes and modulate expression of cancer and inflammation-related genes, including the induction of the expression of tumor suppressor genes and the inhibition of the expression of pro-inflammatory cytokines and inflammatory enzymes, thereby inhibiting the activation of signal transduction pathways involved in carcinogenesis and inflammation, respectively. PLE also stimulates tissue inhibitors of metalloproteinases (TIMPs) and inhibits matrix metalloproteinases (MMPs).\nConcepts: Shallow AC (Anterior chamber anomalies)\tPL Extract (Pharmacologic Substance)\tMyocardial multinucleated giant cells (Myocardial immune cell infiltration)\tDDS02-Teen Management Distress: Mean (Intellectual Product)\tSeronegative (Modifier mainly for procedure)", + "output": "PL Extract (Pharmacologic Substance)" + }, + { + "input": "Definition: EPHA2 gene described as human EPHA2 wild-type allele is located within 1p36 and is approximately 32 kb in length. This allele, which encodes ephrin type-A receptor 2 protein, is involved in mediating developmental events and is heavily involved in the nervous system.\nConcepts: IP-9 (CXCL11 gene)\tCTRCT6 (Gene or Genome)\tMIR509-1 Pre-miRNA (pre-miRNA)\tBlood-vessels--Abnormalities (Cardiovascular Abnormalities)\tmethylthiohexylmalate dehydrogenase activity (Molecular Function)", + "output": "CTRCT6 (Gene or Genome)" + }, + { + "input": "Definition: something described as an olfactory neuroblastoma arising in the nasal cavity.\nConcepts: National Program of Cancer Registries (Professional Organization or Group)\tphenanthrene-D10 (Organic Chemical)\tNB - Neuroblastoma (Embryonal neuroepithelial tumor)\tolfactory neuroblastoma of nasal cavity (Neoplastic Process)\tmeiotic chromosome decondensation (chromosome organization involved in meiotic cell cycle)", + "output": "olfactory neuroblastoma of nasal cavity (Neoplastic Process)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 5q\nConcepts: 5q11.2-q13.1 (Cell Component)\tMAD2B protein, human (Cell Cycle Proteins)\tCollagenases (Amino Acid, Peptide, or Protein)\tRasGAP-Fyn-Lyn-Yes complex (Cell Component)\tmeiosis II nuclear envelope disassembly (meiotic nuclear envelope disassembly)", + "output": "5q11.2-q13.1 (Cell Component)" + }, + { + "input": "Definition: something described as the assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures.\nConcepts: Gram-negative-bacterium-type cell outer membrane assembly (Cell Function)\tmating-type pheromone secretion involved in conjugation with cellular fusion (Cell Function)\t(S)-(-)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzooxazine-6-carboxylic acid (Fluoroquinolone antiinfectives, ophthalmologic)\tglycerate transmembrane transporter activity (Molecular Function)\tMICROCORIA-CONGENITAL NEPHROTIC SYNDROME (Eye Abnormalities)", + "output": "Gram-negative-bacterium-type cell outer membrane assembly (Cell Function)" + }, + { + "input": "Definition: transferase activity, transferring one-carbon groups described as catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor).\nConcepts: carboxyl- or carbamoyltransferase activity (Molecular Function)\tTAVI - transcatheter aortic valve implantation (Insertion of therapeutic device)\tAnal Cancer pTX TNM Finding (Anal Cancer Pathologic Primary Tumor TNM Finding v7)\tTubular breath sounds (Respiratory Sounds)\tChlorfenvinphos (Organophosphate insecticide)", + "output": "carboxyl- or carbamoyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Experimental Organism Neoplasm by Organism described as a condition that is relevant to either disease states or models of disease in gerbils\nConcepts: stage III cancer of the esophagus (Neoplastic Process)\tGerbil Experimental Organism Diagnosis (Disease or Syndrome)\tEyelid Lift (Therapeutic or Preventive Procedure)\tRhabdoid Neoplasm of the Kidney (Neoplastic Process)\tNephro-ureterectomy (Therapeutic or Preventive Procedure)", + "output": "Gerbil Experimental Organism Diagnosis (Disease or Syndrome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as the biotoxin epsilon toxin.\nConcepts: Clostridium perfringens epsilon-toxin (Amino Acid, Peptide, or Protein)\tHimalaya ProSelect(TM) Koflet each 24 lozenges (Nutraceuticals)\tcarbon dioxide membrane transport (carbon dioxide transport)\tProduct containing pemigatinib (Antineoplastic Enzyme Inhibitor)\tBSF1 (Interleukin Gene)", + "output": "Clostridium perfringens epsilon-toxin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Peromelia described as peromelia affecting only the upper limbs. That is, the distal parts of the arm are missing leading to stump formation.\nConcepts: LIFT, PATIENT, AC-POWERED (Medical Device)\tTGFB4 (Transforming Growth Factor-Beta Family Gene)\tDressings, Impregnated (Medical Device)\tUpper limb peromelia (Congenital Abnormality)\td-4,5 unsaturated beta-glucuronyl hydrolase activity (Molecular Function)", + "output": "Upper limb peromelia (Congenital Abnormality)" + }, + { + "input": "Definition: LEC-5 Standard Version Questionnaire Question described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Fire or explosion: Learned about it.\nConcepts: Steep mandibular plane angle (Skull)\tEB1 (Amino Acid, Peptide, or Protein)\tinhibition of dosage compensation, by inactivation of X chromosome (regulation of dosage compensation by inactivation of X chromosome)\tLEC01-Fire or Explosion: Learned (Intellectual Product)\tMicroangiopathic hemolytic anemia (Anemia due to abnormality extrinsic to the red cell)", + "output": "LEC01-Fire or Explosion: Learned (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as citrus medica, fo shou gan\nConcepts: 4-nitrophenol 2-monooxygenase activity (Molecular Function)\tAGEU (Unit by Category)\tSomatic dysfunction of forearm (Finding)\tLARYNGEAL OBSTRUCTION (disorder of throat)\tcitri sarcodactylis/citrus m (Oriental herbs and natural substances letter C)", + "output": "citri sarcodactylis/citrus m (Oriental herbs and natural substances letter C)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the pancreatic triacylglycerol lipase in a biological specimen.\nConcepts: open form four-way junction DNA binding (four-way junction DNA binding)\tBPI - Pain as a Symptom (BPI Questionnaire Question)\tScreening Not Completed (Finding)\tPNLIP (Laboratory Procedure)\tBAY86-7548 (Amino Acid, Peptide, or Protein)", + "output": "PNLIP (Laboratory Procedure)" + }, + { + "input": "Definition: something described as used with drugs and chemicals for substances that share the same parent molecule or have similar electronic structure but differ by the addition or substitution of other atoms or molecules. It is used when the specific chemical heading is not available and no appropriate group heading exists.\nConcepts: liposarcoma of vulva (liposarcoma)\tMicrobial Susceptibility Test (Laboratory Procedure)\tAA (Functional Concept)\tInfection, Poliomyelitis (Infection caused by Human poliovirus)\tSarcomatoid Hepatocellular Cancer (Liver carcinoma)", + "output": "AA (Functional Concept)" + }, + { + "input": "Definition: Wounds and Injuries described as injuries involving the vertebral column.\nConcepts: voltage-gated cation channel activity (cation channel activity)\tOtospongiosis syndrome (Abnormality of the stapes)\tEgo (Psychoanalytic Theory)\tfibronectin-tissue transglutaminase complex (Cell Component)\tINJ SPINAL (Traumatic injury of vertebral region of back)", + "output": "INJ SPINAL (Traumatic injury of vertebral region of back)" + }, + { + "input": "Definition: Combined immunodeficiency disease described as a rare genetic combined T and B cell immunodeficiency characterized by T- and B-cell lymphopenia, hypergammaglobulinemia and intermittent neutropenia. It presents with recurrent opportunistic viral, bacterial and fungal infections involving skin (cutaneous papillomatosis, molluscum contagiosum, skin abscesses, mucocutaneous candidiasis), upper and lower respiratory tract or septicemia. Other clinical features include autoimmune manifestations (autoimmune hemolytic anemia) and congenital heart defects (atrial septal defects, patent foramen ovale, mitral, tricuspid and pulmonary valve insufficiency). Caused by homozygous mutation in the STK4 gene on chromosome 20q13.\nConcepts: entorhinal area, medial part, ventral zone [Haug] (Body Part, Organ, or Organ Component)\taccessory nerve nuclei (Body Part, Organ, or Organ Component)\tCalmette Vaccine (Vaccines)\tCombined immunodeficiency due to STK4 (serine/threonine kinase 4) deficiency (Autosomal recessive hereditary disorder)\tInduced DNA Alteration (Mutation Abnormality)", + "output": "Combined immunodeficiency due to STK4 (serine/threonine kinase 4) deficiency (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: Antineoplastic Enzyme Inhibitor described as a proprietary, suppository-based formulation composed of idronoxil, a synthetic flavonoid derivative, surrounded by a proprietary lipid that protects idronoxil from phase 2 degradation, with potential chemo- and radio-sensitizing activities. Upon administration, idronoxil blocks the activity of ecto-NOX disulfide-thiol exchanger 2 (ENOX2; tNOX), a tumor-specific external NADH oxidase that maintains the transmembrane electron potential across the plasma membrane and is overexpressed in certain cancer cell types while absent in normal, healthy cells. Loss of this potential directly inhibits certain pro-survival signal transduction pathways, such as the PARP1/PI3 kinase/Akt signaling pathway. The inhibition of these pathways prevents resistance to standard chemo- and radio-therapy and makes tumor cells more susceptible to the anti-tumor activity of conventional chemotherapeutic agents and radiotherapy. The formulation prevents detoxification of idronoxil to an inactive form by bypassing phase 2 metabolism; this increases idronoxil's bioavailability as compared to idronoxil alone.\nConcepts: Bachelor of Science (Bachelor's Degree)\tAchorion violaceum (Mitosporic Fungi)\tTraction bronchiectasis (Disease or Syndrome)\tNnspcfd HCPCS mammography rf (Tracking code use with or without ICD diagnosis)\tidronoxil suppository NOX66 (Antineoplastic Enzyme Inhibitor)", + "output": "idronoxil suppository NOX66 (Antineoplastic Enzyme Inhibitor)" + }, + { + "input": "Definition: Nervous System Disorders, CTCAE described as a disorder characterized by characterized by excessive sleepiness during the daytime.\nConcepts: Damage, Internal/External (Finding)\tAlCl3 (Aluminum in topical dosage form)\tLocally Advanced Primary Malignant Central Nervous System Neoplasm (Metastatic Primary Malignant Central Nervous System Neoplasm)\tHypersomnia, CTCAE (Finding)\tPerioperative injury care (Injury care)", + "output": "Hypersomnia, CTCAE (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as the Work Productivity and Activity Impairment - Specific Health Problems Questionnaire Version 2.0 (WPAI-SHP V2.0) (Reilly MC, Zbrozek AS, Dukes EM. The validity and reproducibility of a work productivity and activity impairment instrument. PharmacoEconomics 1993; 4(5):353-65. http://www.reillyassociates.net/WPAI_SHP.html. http://www.reillyassociates.net/WPAI_General.html).\nConcepts: biliary tract pharmacology (Pharmacology)\tWPAI01 (Clinical or Research Assessment Questionnaire)\tHER2-targeting 99mTc-labeled Affibody (Amino Acid, Peptide, or Protein)\tConcentrated Beet Crystals (Antioxidants)\tOrthodontic wire (Orthodontic Appliances)", + "output": "WPAI01 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Bladder Infection, CTCAE 5 described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated\nConcepts: THICK LIPS AND ORAL MUCOSA (Disease or Syndrome)\tCYA (C [Preparations])\tRefractory Primary Malignant Central Nervous System Neoplasm (Malignant Central Nervous System Neoplasm)\tLow drug level (Disorders, General, Functional and NEC)\tGrade 3 Bladder Infection, CTCAE (Finding)", + "output": "Grade 3 Bladder Infection, CTCAE (Finding)" + }, + { + "input": "Definition: Genomic Library described as a genomic library where the sample has been subjected to enrichment via nucleic acid hybridization.\nConcepts: 43-46 DEUTEROMYCOTA - FUNGI IMPERFECTI (Fungus)\tDouche Powder Dosage Form (Biomedical or Dental Material)\tAir Ambulances (Aircraft)\tmeiotic spindle organization (meiotic cell cycle process)\tHybrid Selected Genomic Library (Genomic Library)", + "output": "Hybrid Selected Genomic Library (Genomic Library)" + }, + { + "input": "Definition: something described as data management information system software designed to manage/operate computerized information systems intended for clinical and patient data management. This software is intended to work with one or a few models of hospital data management information systems, usually supplied by the same manufacturer. The software performs a variety of algorithms to process the data usually in specific areas or particular procedures or, less frequently, throughout the facility and also manage the operation of the system. Clinical data management information system software is available as part of the complete information system or as a separate component; the software may be modified (i.e., through the release of modified versions) during the life of the system by releasing updated versions. Dedicated clinical data management software intended only for particular healthcare applications, such as electrocardiography, clinical pharmacy, emergency care, clinical laboratory, anatomic pathology, obstetrics, oncology, radiotherapy, radiology, bedside, blood bank, provider order entry, home care, health record, perioperative, physician practice, and risk management is also available.\nConcepts: NPI1-Appetite/Eating Disorder Frequency (Intellectual Product)\tClinical Data Management Information System Software (Intellectual Product)\tSalbutamol (Ethanolamines)\tCyclo-Oxygenase II (Prostaglandin-Endoperoxide Synthase)\tnegative regulation of cellular response to amino acid starvation (regulation of cellular response to amino acid starvation)", + "output": "Clinical Data Management Information System Software (Intellectual Product)" + }, + { + "input": "Definition: something described as the nature of the investigation or the investigational use for which clinical study is being done.\nConcepts: area 29 (Body Location or Region)\tExperiment Design (study design, planning, execution, and result)\tYarrowia (Ascomycota)\tAbundant (Property or Attribute)\tHAMD-21 - Somatic Symptoms General (Intellectual Product)", + "output": "Experiment Design (study design, planning, execution, and result)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the NCCN-FACT FOSI-18 Version 2 questionnaire.\nConcepts: Hyperuricemia (Metabolism and Nutrition Disorders, CTCAE)\tWAPL protein, human (Amino Acid, Peptide, or Protein)\tEsophageal Squamous Cell Carcinoma Location Category Upper (Esophageal Squamous Cell Carcinoma Location Category)\tEnterobacteria (Coliform bacteria)\tNCCN-FACT FOSI-18 Version 2 Questionnaire Question (Intellectual Product)", + "output": "NCCN-FACT FOSI-18 Version 2 Questionnaire Question (Intellectual Product)" + }, + { + "input": "Definition: T-Lymphocyte Subsets described as subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions; for example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.\nConcepts: WDHA Syndrome (Abnormality of vasoactive intestinal peptide secretion)\tBacitracin-containing product (bactericide)\tfalx cerebri (Central nervous system part)\tSmall Intestine Cancer pT2 TNM Finding v8 (Small Intestine Cancer Pathologic Primary Tumor TNM Finding v8)\tT-helper lymphocyte (Functional Immunologic Units)", + "output": "T-helper lymphocyte (Functional Immunologic Units)" + }, + { + "input": "Definition: Nonsense mutation described as a change in the sequence of the ZRSR2 gene that encodes a premature stop codon.\nConcepts: U2AF1L2 Nonsense Mutation (ZRSR2 Gene Mutation)\tChest pain precordial (BODY AS A WHOLE - GENERAL DISORDERS)\tanti-CD30 monoclonal antibody MDX-1401 (Immunologic Factor)\tDietary Fatty Acid (Organic Chemical)\tHobby horse gait (Finding)", + "output": "U2AF1L2 Nonsense Mutation (ZRSR2 Gene Mutation)" + }, + { + "input": "Definition: Fanconi Anemia described as fanconi anemia caused by mutations of the FANCF gene. This gene encodes a polypeptide with homology to the prokaryotic RNA-binding protein ROM.\nConcepts: Methylprednisolone [endoc] (M [Preparations])\tFanconi Anemia, Complementation Group F (Disease or Syndrome)\tSubtotal lobectomy of thyroid (Therapeutic or Preventive Procedure)\tAgaA (Molecular Function)\tvery long-chain fatty-acyl-CoA catabolic process (very long-chain fatty-acyl-CoA metabolic process)", + "output": "Fanconi Anemia, Complementation Group F (Disease or Syndrome)" + }, + { + "input": "Definition: Benign neoplasm of meninges described as a benign tumor occurring in the meninges, which surround the brain and spinal cord. The most common are meningiomas.\nConcepts: Benign Meningeal Neoplasms (Meningeal Neoplasms)\tx-linked mendelian susceptibility to mycobacterial disease (Immunodeficiency associated with chromosomal abnormality)\tExtreme generalized edema (MUSCLE SOFT, TISSUE)\tOphthalmic Exam Test Name (Intellectual Product)\tHomeobox 1.8 Positive (Laboratory or Test Result)", + "output": "Benign Meningeal Neoplasms (Meningeal Neoplasms)" + }, + { + "input": "Definition: something described as an essential, polyunsaturated, 20-carbon omega-3 fatty acid with anti-inflammatory and potential antineoplastic and chemopreventive activities. Eicosapentaenoic acid (EPA) may activate caspase 3, resulting in apoptosis in susceptible tumor cell populations. In addition, this agent may inhibit cyclooxygenase-2 (COX-2), resulting in inhibition of prostaglandin synthesis and prostaglandin-mediated inflammatory processes. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C67080\" active clinical trials using this agent.\nConcepts: Human Mammary Neoplasm (Neoplastic Process)\tFGF-5 (Fibroblast Growth Factor)\tsyndrome; cervical, rib (Cervical rib)\t5,8,11,14,17-Icosapentaenoic acid (omega-3 fatty acids)\tSISTER, BIOLOGICAL MATERNAL HALF (Half-sister)", + "output": "5,8,11,14,17-Icosapentaenoic acid (omega-3 fatty acids)" + }, + { + "input": "Definition: Geographic Area described as a principality in the Pyrenees between France and Spain. Its capital is also called Andorra.\nConcepts: Clinical Stage IIA Gastric Cancer AJCC v8 (Clinical Stage II Gastric Cancer AJCC v8)\tinfectious disease diagnosis (Diagnosis)\tMurine sarcoma virus (Murine sarcoma viruses)\tCarts, Filing, Radiographic Film/Cassette (Medical Device)\tANDORRA (Europe)", + "output": "ANDORRA (Europe)" + }, + { + "input": "Definition: something described as this gene is involved in binding to glycosaminoglycans and phospholipids.\nConcepts: Ileal Perforation (Gastrointestinal Disorders, CTCAE)\talphaV-beta3 integrin-gelsolin complex location (plasma membrane protein complex)\tPicomole/gram (moles per unit mass)\tProtein or Riboprotein Complex (Genome Encoded Entity)\tGLYCOPROTEIN I, BETA-2 (Ligand Binding Protein Gene)", + "output": "GLYCOPROTEIN I, BETA-2 (Ligand Binding Protein Gene)" + }, + { + "input": "Definition: Mental Retardation described as deletion of the long arm of chromosome 9. It is a rare chromosomal aberration with a variable phenotype. Common manifestations include hypotonia, growth and mental retardation, and down-slanting or oblique palpebral fissures. Additional anomalies may include arhinencephaly, malformed ears, atrial or ventricular septal defects, and lung hypoplasia.\nConcepts: lupeol 28-oxidase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tData Processors, Tape Recording (Manufactured Object)\tmonosomy 9q (Rare Non-Neoplastic Disorder)\tAVL01-List A Recall 2 Word 2 (ADNI-AVLT Questionnaire Question)\tsubject monitoring (Research Activity)", + "output": "monosomy 9q (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Acetylcholinesterase Inhibitors described as the organophosphorus agent demeton-o.\nConcepts: Demeton-O (Acetylcholinesterase Inhibitors)\tEDN2 (Gene or Genome)\tSequencing, Chromatin Immunoprecipitation (chromatin immunoprecipitation)\tStreptococcus pneumoniae Serotype 8 IgG Antibody (Streptococcus pneumoniae IgG Antibody Measurement)\tMIRROR, MOUTH (Mirror)", + "output": "Demeton-O (Acetylcholinesterase Inhibitors)" + }, + { + "input": "Definition: positive regulation of cellular process described as any process that activates or increases the frequency, rate, extent or direction of cell growth.\nConcepts: METABOLITES (Toxicology: Other Toxicity Studies)\tpositive regulation of determination of dorsal identity (regulation of determination of dorsal identity)\tRibosomal Protein S3 wt Allele (RPS3 gene)\tupregulation of cell growth (Cell Function)\tVitamin F (Eicosanoids)", + "output": "upregulation of cell growth (Cell Function)" + }, + { + "input": "Definition: Medical Errors described as an error associated with the prescribing, dispensing, or giving/taking a medication by a healthcare professional, patient, or consumer that causes or leads to inappropriate medication use or patient harm.\nConcepts: JELLY, CONTACT, FOR TRANSURETHRAL SURGICAL INSTRUMENT (Medical Device)\tMedication Errors (Disorders, General, Functional and NEC)\tInjectable Lyophilized Powder Dosage Form (Biomedical or Dental Material)\tSynthase, Farnesyl Diphosphate (Alkyl and Aryl Transferases)\tdown regulation of peptide antigen transport (Molecular Function)", + "output": "Medication Errors (Disorders, General, Functional and NEC)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of two divisions of the sensorimotor thalamus defined on the basis of connectivity and function (see Models Where It Appears below). It is the same as the metathalamus of the classical brain model except that it does no include the pregeniculate nucleus. The other division is the ventral group of the dorsal thalamus ( Swanson-2004 ) .\\r\\n\nConcepts: geniculate group, dorsal thalamus (Body Part, Organ, or Organ Component)\tMotexafin Gadolinium (Organic Chemical)\tBronchodilator Agents (Autonomic Agents)\tTEST,CARBOHYDRATE DEFICIENT TRANSFERRIN (Laboratory Procedure)\ttartrate metabolism (Metabolism)", + "output": "geniculate group, dorsal thalamus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as heart sounds are auscultated on the precordial location corresponding to the region between the third and fifth intercostal spaces at the left sternal border.\nConcepts: Rules, Clinical Prediction (Intellectual Product)\tLeft middle sternal border (Heart Sounds)\tCa phobia (Fear of contracting disease)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TYMP (Medical Device)\tAbnormal peripheral nervous system synaptic transmission (Abnormal synaptic transmission)", + "output": "Left middle sternal border (Heart Sounds)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of measurement referring to one entity counted per one million entities.\nConcepts: lectin (Antibody type)\tPart per Million (Unit of fractional measurement)\tPrimary Diffuse Large B-Cell Gastric Lymphoma (Neoplastic Process)\tmale germline ring canal formation (Cell Function)\tCT24.2 (Immunoproteins)", + "output": "Part per Million (Unit of fractional measurement)" + }, + { + "input": "Definition: Type of drug preparation described as medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.\nConcepts: Co-Investigator (Investigator by Role in Study)\tSTROMAL TUMOR, BENIGN (Experimental Organism Neoplasm)\tNFkB activation by Nontypeable Hemophilus influenzae (Infectious Disease Pathway)\tHypothalamic Hypothyroidism (Secondary hypothyroidism)\tSUPP (SolidDrugForm)", + "output": "SUPP (SolidDrugForm)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = amorpha-4,11-diene + diphosphate.\nConcepts: 2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity (sesquiterpene synthase activity)\tMucopolysaccharidosis Type IIID (Mucopolysaccharidosis III)\tOrobanche L. (Orobancheae)\tADL03-Pastime: Art (ADCS-ADL MCI Questionnaire Question)\tglucosylglycerate hydrolase activity (Molecular Function)", + "output": "2-trans,6-trans-farnesyl-diphosphate diphosphate-lyase (amorpha-4,11-diene-forming) activity (sesquiterpene synthase activity)" + }, + { + "input": "Definition: FACT-C Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Colorectal Version 4 - Additional Concerns: I am losing weight.\nConcepts: Zirconium Zr 89 DFO-MSTP2109A (Radioimmunoconjugates)\tMild Bronchopulmonary Dysplasia (Disease or Syndrome)\tShortness of Breath Score 8 (Shortness of Breath Visual Analogue Scale)\tFAC00829 (Intellectual Product)\t3'-5' RNA polymerase activity (RNA polymerase activity)", + "output": "FAC00829 (Intellectual Product)" + }, + { + "input": "Definition: something described as confirming the accuracy, authenticity, and thoroughness of information by comparing it to original information and records.\nConcepts: source data verification (Verification)\tNET13 (Gene or Genome)\tSapporo virus (Virus)\tVFQ25-Interviewer Administered Format - Difficulty Recognizing People You Know (VFQ25-Interviewer Administered Format Questionnaire Question)\tPeritoneal Lymph Node (Body Part, Organ, or Organ Component)", + "output": "source data verification (Verification)" + }, + { + "input": "Definition: Manufactured Object described as recorders designed to record some physical, chemical, or other conditions and elements in the environment (e.g., particulates) to which individuals may be exposed; environmental recorders are intended for data examination after the events have occurred. Environmental recorders usually consist of an electromechanical or electronic device that includes amplifiers, data processors, and a memory (e.g., electronic, optical, chart) to store the information. Some recorders may include a display and/or integral printers; other recorders provide output to computers for analysis of the recorded information employing dedicated software. Environmental recorders are used mainly to determine the presence of the concentrations of gases (e.g., oxygen, carbon dioxide); some dedicated recorders are used to store information regarding the presence of hazardous substances (e.g., toxic gases, chemical and biological agents) and/or other abnormal physical conditions in the environment (e.g., high or low temperatures, ionizing radiation. Some environmental recorders warn of a hazardous condition when predetermined substance concentrations have been reached or exceeded.\nConcepts: Nerve root, NOS (Nerve Tissue)\tLissencephaly due to TUBA1A (tubulin alpha 1A) mutation (Autosomal dominant hereditary disorder)\tEnvironmental Recorders (Manufactured Object)\tReceptor Associated Protein 80 (Amino Acid, Peptide, or Protein)\tOrphan Nuclear Receptor PXR (Amino Acid, Peptide, or Protein)", + "output": "Environmental Recorders (Manufactured Object)" + }, + { + "input": "Definition: Body Location or Region described as midline anatomical point of skull at inferior border of mandible.\nConcepts: Retinochoroiditis NOS (Uveitis)\tGnathion (Body Location or Region)\tlevan fructotransferase (DFA-IV-forming) activity (carbon-oxygen lyase activity, acting on polysaccharides)\tWaste Receptacles, Radioactive Material (Waste Receptacles)\toklahoma (Southwestern United States)", + "output": "Gnathion (Body Location or Region)" + }, + { + "input": "Definition: something described as expulsion of the products of conception before the completion of gestation.\nConcepts: Bone Mineral Density Z-Score (Quantitative Concept)\tIL-10 secretion (Cell Function)\tPregnancy Loss (Pregnancy)\tPrognosis Marker (Qualitative Concept)\tRun action (Action)", + "output": "Pregnancy Loss (Pregnancy)" + }, + { + "input": "Definition: International unit measurement described as a unit equal to one-millionth of an international unit.\nConcepts: Low risk (Finding)\tammonium benzoicum/ammonium (Pharmacologic Substance)\tSoft Tissue Sarcoma of the Head and Neck pN1 TNM Finding v8 (Soft Tissue Sarcoma of the Head and Neck Pathologic Regional Lymph Nodes TNM Finding v8)\tCold-induced muscle cramps (Peripheral Nervous System)\tMicrointernational unit (International Unit)", + "output": "Microinternational unit (International Unit)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio or percentage) of the squamous epithelial cells to total cells in a biological specimen.\nConcepts: Conjunctival Melanoma pT1b TNM Finding v8 (Finding)\tSquamous Epithelial Cells/Total Cells (Laboratory Procedure)\tperillyl alcohol dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tisoflavonoid phytoalexin biosynthetic process (Molecular Function)\tDAD - Go Out and Reach a Familiar Destination Without Getting Lost (Intellectual Product)", + "output": "Squamous Epithelial Cells/Total Cells (Laboratory Procedure)" + }, + { + "input": "Definition: Stage IIC Colorectal Cancer AJCC v8 described as stage IIC includes: T4b, N0, M0. T4b: Tumor directly invades or adheres to adjacent organs or structures. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Chronic Brain Injury (Brain Injuries)\tRAB A 002 GTP BINDING PROTEIN (Enzyme)\tnursing quality care (Qualitative Concept)\tStage IIC Colon Cancer (Stage IIC Colorectal Cancer AJCC v8)\tviral release (Cell Function)", + "output": "Stage IIC Colon Cancer (Stage IIC Colorectal Cancer AJCC v8)" + }, + { + "input": "Definition: something described as tissue that occupies the area between the soft palate and upper portion of the epiglottis.\nConcepts: GLUT1 (Gene or Genome)\tRAD50 (S. cerevisiae) Homolog Gene Mutation (Cell or Molecular Dysfunction)\tFludroxycortide product (topical steroids)\tOropharyngeal Tissue (Tissue)\tsulfate transmembrane transporter activity (inorganic anion transmembrane transporter activity)", + "output": "Oropharyngeal Tissue (Tissue)" + }, + { + "input": "Definition: Central Nervous System described as persistent difficulties in the social uses of verbal and nonverbal communications.\nConcepts: Increased proportion of CD8-positive, alpha-beta TEMRA T cells (Abnormal proportion of CD8-positive, alpha-beta TEMRA T cells)\tStillbirth indicator (Indicator)\tEating disorder counseling family each 15 minutes (mental health counseling)\tsocial pragmatic communication disorder (Actual Impaired Interactive Behavior)\tlung vasculature development (Organ or Tissue Function)", + "output": "social pragmatic communication disorder (Actual Impaired Interactive Behavior)" + }, + { + "input": "Definition: Canis familiaris described as a small version of a working terrier with a harsh, shaggy coat, and longer hair all over the face. The coat is usually black or dark grey, but tan and red are also possible. The average height is 10-15 inches and weight is 7-8 pounds.\nConcepts: VIRU (Immunologic Adjuvants)\tNucleus amygdaloideus corticalis (Body Part, Organ, or Organ Component)\tPercutaneous allergy test immediate-type reaction sequential and incremental with substance(s) each test (Laboratory Procedure)\tAffenpinscher (Toy Breed)\tD5-D6 HEMOGLOBINS (Hematology analyte)", + "output": "Affenpinscher (Toy Breed)" + }, + { + "input": "Definition: Coumarin Compound described as synthetic coumarin anticoagulant.\nConcepts: regulation of postsynaptic neurotransmitter receptor endocytosis (regulation of receptor internalization)\tStage III Urethral Carcinoma AJCC v8 (Urethral Cancer by AJCC v8 Stage)\t4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin (4-hydroxycoumarin)\tanammoxosome (intracellular membrane-bounded organelle)\tProdigiozan (Polysaccharides, Bacterial)", + "output": "4-Hydroxy-3-(3-oxo-1-phenylbutyl)coumarin (4-hydroxycoumarin)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 - During the past week: Have you felt nauseated?\nConcepts: COMPUTER, DIAGNOSTIC, PRE-PROGRAMMED, SINGLE-FUNCTION (Medical Device)\tEOR0114 (Intellectual Product)\tHD-CAB Functional Test Question (Clinical or Research Assessment Question)\tCDISC SDTM Implementation Guide Version 3.3 (Intellectual Product)\tFMS-Related Tyrosine Kinase 3 c.1992G>T (Non-synonymous FLT3 Gene Mutation)", + "output": "EOR0114 (Intellectual Product)" + }, + { + "input": "Definition: Proteins described as the proteinaceous component of the pancreatic stone in patients with PANCREATITIS.\nConcepts: Lithostatin (Pancreatitis-Associated Proteins)\tStructure of retinal vein (Structure of vein of head)\tnegative regulation of tolerance induction to nonself antigen (Physiologic Function)\tMETRIZOIC ACID (Organic Chemical)\tC-SSRS Already Enrolled Subjects - Reasons For Most Severe Ideation (Intellectual Product)", + "output": "Lithostatin (Pancreatitis-Associated Proteins)" + }, + { + "input": "Definition: hemoglobin metabolic process described as the chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids.\nConcepts: primase (DNA-Directed RNA Polymerase)\tupregulation of transport (regulation of transport)\tNeurosciences Research (Research Activity)\thaemoglobin catabolism (cellular macromolecule catabolic process)\tCancer Care Outcomes Research and Surveillance Consortium (Cancer Surveillance Project)", + "output": "haemoglobin catabolism (cellular macromolecule catabolic process)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent operative intervention indicated\nConcepts: PerformedProductInvestigationResult (Result)\tGrade 4 Gastric stenosis (Gastric Stenosis, CTCAE)\tGAIA Level 2 First Trimester Spontaneous Abortion (Intellectual Product)\tLabyrinth Supporting Cell (Cells)\tGrade 4 Small Intestine Ulcer, CTCAE (Small Intestine Ulcer, CTCAE)", + "output": "Grade 4 Gastric stenosis (Gastric Stenosis, CTCAE)" + }, + { + "input": "Definition: Pathologic Function described as an overall level of substantial worsening in non-target disease that is of a magnitude that, even in the presence of SD or PR in target disease, the treating physician would feel it important to change therapy.\nConcepts: Ovalocyte Count (Laboratory Procedure)\tlaryngeal spasms (Spasm)\tmembrane raft (Plasma membrane)\tUnequivocal Progression (Pathologic Function)\tHow Much Time Feel Worried (Clinical or Research Assessment Question)", + "output": "Unequivocal Progression (Pathologic Function)" + }, + { + "input": "Definition: Finding described as a severe form of hypermetropia with over +5.00 diopters.\nConcepts: Carmustine-Cyclophosphamide-Doxorubicin (Therapeutic or Preventive Procedure)\tIncreased serum lactate (Acidosis)\tHigh-grade hypermetropia (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast, Candida Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Fungi/Yeast)\tapurinic-apyrimidinic endonuclease 2, human (Enzyme)", + "output": "High-grade hypermetropia (Finding)" + }, + { + "input": "Definition: positive regulation of microtubule polymerization or depolymerization described as any process that activates or increases the frequency, rate or extent of microtubule depolymerization.\nConcepts: upregulation of microtubule depolymerization (positive regulation of supramolecular fiber organization)\tEOR02-Pain Interfere Daily Activities (Intellectual Product)\tindole-containing compound breakdown (indole-containing compound metabolic process)\tOligomers, Phosphorodiamidate Morpholino (Nucleic Acid, Nucleoside, or Nucleotide)\tprespliceosome (Spliceosomes)", + "output": "upregulation of microtubule depolymerization (positive regulation of supramolecular fiber organization)" + }, + { + "input": "Definition: Finding described as the results of any chemical or enzymatic analyses of body fluids and tissues of an organism.\nConcepts: Clinical Chemistry Finding (Finding)\tDental Burs (Device associated with dental drilling systems)\tUnopened tricuspid valve (Anatomical Abnormality)\tCIC-DUX4 Fusion Protein Expression (Fusion Protein Expression)\tProduct containing mannitol (Alcohols)", + "output": "Clinical Chemistry Finding (Finding)" + }, + { + "input": "Definition: something described as a complete description of each unique treatment regimen to uniformly group patients for separate analysis of adverse events and response data.\nConcepts: TAD (Intellectual Product)\tReceptor, KISS1 (G-Protein-Coupled Receptors)\tPowder for Intraocular Instillation Solution Dosage Form (Biomedical or Dental Material)\tprotein localisation to chromosome, centromeric region (Cell Function)\tbiometrics (Occupation or Discipline)", + "output": "TAD (Intellectual Product)" + }, + { + "input": "Definition: something described as the date (and time) on which this individual participated in authoring the document version. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: Document Author Date (Date in time)\tDental Providers; Dentist, Endodontics (Professional or Occupational Group)\tup regulation of axon extension (regulation of axon extension)\tADCOR07 (Intellectual Product)\tMacrocytic Anemia, Refractory, Due To 5q Deletion (MYELODYSPLASTIC SYNDROME)", + "output": "Document Author Date (Date in time)" + }, + { + "input": "Definition: Benign neoplasm of meninges described as a benign neoplasm of the meninges.\nConcepts: Beta-2 Globulin to Total Protein Ratio Measurement (Laboratory Procedure)\tBenign Meningioma (Benign neurologic neoplasms)\tallogeneic glioblastoma stem-like cell line lysate-pulsed autologous dendritic cell vaccine (Dendritic Cell Vaccine)\tTriacetyl uridine (Various alimentary tract and metabolism products)\tInterstitial tissue of kidney (Renal Tissue)", + "output": "Benign Meningioma (Benign neurologic neoplasms)" + }, + { + "input": "Definition: something described as the administration of a drug within or into a vein or veins over a sustained period of time. A slow, continuous drip avoids excessively high transient peak plasma levels.\nConcepts: Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody (Pharmacologic Substance)\tPretesticular azoospermia (Finding)\tAorticopulmonary paraganglioma (Central Nervous System Neoplasms)\tInfusions, Drip (Functional Concept)\tregulation of fever generation by regulation of prostaglandin biosynthesis (regulation of prostaglandin biosynthetic process)", + "output": "Infusions, Drip (Functional Concept)" + }, + { + "input": "Definition: something described as any process that modulates the activity of the enzyme NAD(P)H oxidase.\nConcepts: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen - Hard to Swallow Food (Intellectual Product)\tregulation of NAD(P)H oxidase activity (Molecular Function)\tRight ventricular hypoplasia (Heart)\tHER2 Overexpressing Subtype of Breast Carcinoma (Breast Carcinoma by Gene Expression Profile)\tPerihilar Bile Duct Cancer pTis TNM Finding v7 (Finding)", + "output": "regulation of NAD(P)H oxidase activity (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as human GUCY1B2 wild-type allele is located within 13q14.2-q14.3 and is approximately 71 kb in length. This allele, which encodes guanylate cyclase soluble subunit beta-2 protein, is involved in nitric oxide binding and cyclic GMP biosynthesis.\nConcepts: CNS3a (Classification)\tGuanylate Cyclase 1, Soluble, Beta-2 Gene (GUCY1B2 gene)\tklinefelter syndrome (congenital conditions)\tOral drops, solution (Oral drops)\tRespiratory Mucosa (Respiratory System)", + "output": "Guanylate Cyclase 1, Soluble, Beta-2 Gene (GUCY1B2 gene)" + }, + { + "input": "Definition: Lymph Node by Anatomic Site described as a lymph node located in the retrosacral region.\nConcepts: Retrosacral Lymph Node (Lymph Node by Anatomic Site)\tMammographic Image Detection Computer-Aided Detection System Software (Intellectual Product)\tDouble-armed TMZ-CD40L/4-1BBL Oncolytic Ad5/35 Adenovirus LOAd703 (Virus)\thypothalamic pituitary adrenal (HPA) axis (Structure of subdivision of endocrine system)\tc.1657C>T (Finding)", + "output": "Retrosacral Lymph Node (Lymph Node by Anatomic Site)" + }, + { + "input": "Definition: Oncologic complications and emergencies described as increased reticular fiber deposition within bone marrow.\nConcepts: Bone marrow reticulin fibrosis (Finding)\tSalmonella enterica serovar Paratyphi A (Salmonella paratyphi)\tChicanas (Population Group)\tcobalt-precorrin-7 C15-methyltransferase activity (Molecular Function)\tprotein localisation to cleavage furrow (protein localization to cell division site)", + "output": "Bone marrow reticulin fibrosis (Finding)" + }, + { + "input": "Definition: Ribosome Subunit Gene described as this gene is involved in mitochondrial RNA translation.\nConcepts: Myosclerosis (Congenital Disorders)\tMRPL45 gene (Ribosome Subunit Gene)\tMK-1454 (Pharmacologic Substance)\tBooks (Printed Communications Media)\tIOHEXCLR (Laboratory Procedure)", + "output": "MRPL45 gene (Ribosome Subunit Gene)" + }, + { + "input": "Definition: something described as the specific anatomical or biological region within the tissue or organ specimen used in the laboratory assessment.\nConcepts: Laboratory Test Results Anatomical Region of Specimen (Other Anatomic Concept)\tUNQ178/PRO204 (Gene or Genome)\tAhR Inhibitor BAY2416964 (Immunologic Factor)\tANT (Gene or Genome)\tBioreactor Culture Biosynthesis (Cell Culture-Based Biosynthesis)", + "output": "Laboratory Test Results Anatomical Region of Specimen (Other Anatomic Concept)" + }, + { + "input": "Definition: Cell Function described as the aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell-cell junction composed of the epithelial cadherin-catenin complex at which the cytoplasmic face of the plasma membrane is attached to actin filaments.\nConcepts: HYDROCORTISONE ACETATE (generic drug products begining with the letter H)\tclass III PI3K complex (phosphatidylinositol 3-kinase complex)\tGrade 1 Jejunal stenosis (Jejunal Stenosis, CTCAE)\tadherens junction assembly (adherens junction organization)\tBovine Respiratory Disease Complex (Respiratory Tract Infections)", + "output": "adherens junction assembly (adherens junction organization)" + }, + { + "input": "Definition: something described as an amino acid and herbal supplement with libido-enhancing activity. L-arginine/Korean ginseng/Ginkgo biloba/Damiana-based supplement contains a blend of the amino acid L-arginine and the herbs Korean ginseng, Ginkgo biloba, and damiana (Turnera aphrodisiaca) in addition to 14 other vitamins and minerals. The semi-essential amino acid L-arginine is a precursor for nitric oxide (NO); Korean ginseng may enhance the conversion of L-arginine into NO by NO synthase; and Ginkgo biloba may promote microvascular circulation. This agent may increase NO production, resulting in vasodilatation and an enhanced circulation critical to sexual function and arousal. The damiana component may exert an anxiolytic effect and stimulate sexual behavior.\nConcepts: ArginMax For Women (Pharmacologic Substance)\t3 hourly (GTSAbbreviation - CodeSystem)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Haemophilus Species (IVD Test Reagent/Kits, Microbiology, Bacteria, Identification)\tLinE complex assembly (Cell Function)\tNODAL (Amino Acid, Peptide, or Protein)", + "output": "ArginMax For Women (Pharmacologic Substance)" + }, + { + "input": "Definition: Electrical or magnetic described as any elsewhere undefined electrical or magnetic modality, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Rickettsia felis Bouyer et al. 2001 emend. La Scola et al. 2002 (spotted fever group)\tDROP (Unit of volume)\tmidazolam (short-acting benzodiazepines)\tCOL1A1/PDGFB FUSION GENE (Fusion Gene)\tundef.lctrcmgntc mdalty narr (Therapeutic or Preventive Procedure)", + "output": "undef.lctrcmgntc mdalty narr (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: ABNORMAL CELLS AND CELL STRUCTURES described as a type of macrophage that ingests low-density lipoproteins found in fatty deposits on blood vessel walls, resulting in a foamy appearance.\nConcepts: cell foam (ABNORMAL CELLS AND CELL STRUCTURES)\tRecurrent Mixed Phenotype Acute Leukemia (Recurrent Acute Leukemia)\tIVD Test Reagent/Kits, Immunoassay, Toxicology, Antidepressant, Desipramine (IVD Test Reagent/Kits, Immunoassay, Toxicology, Antidepressant)\tKit - unit of product usage (Qualitative Concept)\tbile duct; obstruction (Bile Duct Diseases)", + "output": "cell foam (ABNORMAL CELLS AND CELL STRUCTURES)" + }, + { + "input": "Definition: Malignant neoplasm of postcricoid region described as a carcinoma of the hypopharynx that arises from the postcricoid region.\nConcepts: 10^6{VP} (Quantitative Concept)\tMicroscopic Angioscopy (Cardiovascular investigation)\tAnal Cancer pTX TNM Finding v6 and v7 (Anal Cancer Pathologic Primary Tumor TNM Finding v6)\tQS-RAND-36 V1.0 TEST (Intellectual Product)\tCancer of Postcricoid Area (Neoplasm of upper respiratory tract)", + "output": "Cancer of Postcricoid Area (Neoplasm of upper respiratory tract)" + }, + { + "input": "Definition: Genetic Function described as any process that modulates the frequency, rate or extent of snoRNA metabolic process.\nConcepts: regulation of snoRNA metabolism (regulation of RNA metabolic process)\tCEBPE Gene (Transcription factor genes)\tnegative cofactor 2 complex location (Cell Component)\tMethane monooxygenase (Oxidoreductase)\tregulation of proline transport (Molecular Function)", + "output": "regulation of snoRNA metabolism (regulation of RNA metabolic process)" + }, + { + "input": "Definition: Gallbladder Carcinoma described as a term that refers to the staging of gallbladder cancer according to the American Joint Committee on Cancer, 6th edition.\nConcepts: Decreased urinary 1-methylhistidine (Abnormal urinary 1-methylhistidine concentration)\tGallbladder Cancer by AJCC v6 Stage (Neoplastic Process)\tCord Blood Transplant Recipient (Transplant Recipients)\tDistal deletion 20q (Disease or Syndrome)\tHepatitis C Virus Antigen Measurement (Laboratory Procedure)", + "output": "Gallbladder Cancer by AJCC v6 Stage (Neoplastic Process)" + }, + { + "input": "Definition: South Central Asia described as a country in southern Asia, occupying an island in the Indian Ocean, southeast of India.\nConcepts: GDS - Frequently Feel Like Crying (GDS Questionnaire Question)\tsphingolipid catabolism (organonitrogen compound catabolic process)\tCeylon (Indian subcontinent country)\thandbooks (Publications)\tAbnormality of the small intestine (Abnormality of the intestine)", + "output": "Ceylon (Indian subcontinent country)" + }, + { + "input": "Definition: Lead Indicator described as specifies whether this is the principal administrative organization responsible for the study. NOTE(S): Exception: A multi-site trial with no single assigned coordination center; in this case, every participating organization can be named as lead organization.\nConcepts: CSS11-Wish to be Dead-Life (C-SSRS Lifetime/Recent Version Questionnaire Question)\tMal neo lacrimal gland (Neoplasm by body site)\tFLUORESCENT IMMUNOASSAY, THEOPHYLLINE (Medical Device)\tStudySite.leadIndicator (Qualitative Concept)\tFebrile infection-related epilepsy syndrome (Inflammatory disorders following infection)", + "output": "StudySite.leadIndicator (Qualitative Concept)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of corticosteroid hormone secretion.\nConcepts: Computer Bags/Cases (Reusable Devices)\tCocculine Extract (Pharmacologic Substance)\tpositive regulation of corticosteroid hormone secretion (Cell Function)\tupregulation of myeloid progenitor cell differentiation (positive regulation of hematopoietic progenitor cell differentiation)\tCongenital Dyserythropoietic Anemia (CDA) Gene Panel Reagents (Medical Device)", + "output": "positive regulation of corticosteroid hormone secretion (Cell Function)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is able to take their medicine.\nConcepts: Can you take your own medicines (Intellectual Product)\tFTGRPID (Group ID)\tAbility to Get Up from Kneeling (Clinical or Research Assessment Question)\tGerman Pinscher (Terrier)\tBalantidium Claparede & Lachmann, 1858 (Ciliophora)", + "output": "Can you take your own medicines (Intellectual Product)" + }, + { + "input": "Definition: something described as human SLC3A2 wild-type allele is located in the vicinity of 11q13 and is approximately 33 kb in length. This allele, which encodes 4F2 cell-surface antigen heavy chain protein, is involved in amino acid transport.\nConcepts: CD22 (Laboratory Procedure)\tIL1RAPL1 (Gene or Genome)\tMusculus opponens pollicis (Entire thenar muscle)\tPhD in Human Services (Intellectual Product)\tNACAE (SLC3A2 gene)", + "output": "NACAE (SLC3A2 gene)" + }, + { + "input": "Definition: Gene or Genome described as human HOXA11 wild-type allele is located in the vicinity of 7p15.2 and is approximately 4 kb in length. This allele, which encodes homeobox protein Hox-A11, plays a role in transcriptional regulation. Mutation of the gene is associated with radioulnar synostosis with amegakaryocytic thrombocytopenia. Two chromosomal aberrations inv(7)(p15q34) and t(7;7)(p15;q34) of this gene and the TCRB gene locus lead to ectopic expression of the HOXA11 gene and are associated with T-cell acute lymphoblastic leukemia. A chromosomal translocation t(7;11)(p15;p15) of this gene and the NUP98 gene might be associated with chronic myelogenous leukemia.\nConcepts: FLT3/TKD Point Mutation (Point Mutation)\tRNA Folding (Genetic Function)\tHOXA11 wt Allele (HOXA11 gene)\tChromodomain Helicase-DNA-Binding Protein 2 (Amino Acid, Peptide, or Protein)\tDouble-Blind Study (Research Design)", + "output": "HOXA11 wt Allele (HOXA11 gene)" + }, + { + "input": "Definition: something described as an antibody that recognizes a tumor-associated antigen (TAA) and is induced and expressed following immunization by a therapeutic antibody targeting the same TAA.\nConcepts: Induced Anti-Tumor-Associated Antigen Antibody (Amino Acid, Peptide, or Protein)\tAllopathic & Osteopathic Physicians; Radiology, Body Imaging (Professional or Occupational Group)\ttype 2 diabetes mellitus autosomal dominant (Diabetes Mellitus, Non-Insulin-Dependent)\tADAM Family Gene (Metallopeptidase Gene)\tFamily History of Stomach Cancer Absent (CPTAC Responses)", + "output": "Induced Anti-Tumor-Associated Antigen Antibody (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Mediastinum described as a conical membranous sac filled with serous fluid in which the heart as well as the roots of the aorta and other large blood vessels are contained.\nConcepts: Edema Rating 3 (Intellectual Product)\tpericardium (Body Part, Organ, or Organ Component)\tMETHYLMALONIC ACIDURIA, cblB TYPE (Methylmalonic acidemia)\tCDRS-R - Excessive Fatigue (CDRS-R Clinical Classification Question)\tCleidoclast (Forceps)", + "output": "pericardium (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate.\nConcepts: L-mimosine synthase activity (Molecular Function)\tnecrosis soft tissue neck (Pathologic Function)\tImmune-Modified Response Evaluation Criteria in Solid Tumors (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, NSD1 (Medical Device)\tp aminosalicylate (Drug groups primarily affecting the musculoskeletal system)", + "output": "L-mimosine synthase activity (Molecular Function)" + }, + { + "input": "Definition: regulation of antifungal innate immune response described as any process that stops, prevents or reduces the frequency, rate or extent of an antifungal innate immune response.\nConcepts: Phase IV Clinical Trials (Research Activity)\tMeasles virus (Virus)\tdown-regulation of antifungal innate immune response (regulation of antifungal innate immune response)\tDigestive (Organism Function)\tcellodextrin catabolic process (Molecular Function)", + "output": "down-regulation of antifungal innate immune response (regulation of antifungal innate immune response)" + }, + { + "input": "Definition: Finding described as reduced criculating level of apolipoprotein AI, which is the major protein component of high density lipoprotein (HDL) in plasma. Defects in this gene are associated with HDL deficiencies, including Tangier disease.\nConcepts: Grade 4 Esophageal necrosis (Esophageal Necrosis, CTCAE)\tatresia; colon (Congenital anomaly of large intestine)\tAPPLICATOR (LARYNGO-TRACHEAL), TOPICAL ANESTHESIA (Medical Device)\tDecreased apo-AI level (Abnormal apolipoprotein level)\tO,S-dimethyl N-acetyl phosphoramidothioate (Pesticides)", + "output": "Decreased apo-AI level (Abnormal apolipoprotein level)" + }, + { + "input": "Definition: Body Space or Junction described as nonsynovial joint in which the articulating bones are connected by bone. Examples: epiphyseal junction, manubriosternal synostosis.\nConcepts: LAG2 (Gene or Genome)\tbony union (Body Space or Junction)\tall-trans-neoxanthin metabolism (xanthophyll metabolic process)\tPartial Wave Spectroscopic Microscopy (Laboratory Procedure)\tviscoelastic solution (Non-Active Implantable Devices)", + "output": "bony union (Body Space or Junction)" + }, + { + "input": "Definition: Distal arthrogryposis syndrome described as rare multiple congenital contracture syndrome characterized by contractures of distal joints of the limbs, triangular face, downslanting palpebral fissures, small mouth, and high arched palate.\nConcepts: Beta-Globin c.364G>A (HBB Gene Mutation)\tcryoglobulinemia (Abnormality of humoral immunity)\tarthrogryposis distal type 2b (Disease or Syndrome)\tobstruction; delivery (COMPLICATIONS OCCURRING MAINLY IN THE COURSE OF LABOR AND DELIVERY)\tneoplasm/cancer immunotherapy (neoplasm/cancer therapy)", + "output": "arthrogryposis distal type 2b (Disease or Syndrome)" + }, + { + "input": "Definition: something described as this gene plays a role in RNA processing.\nConcepts: vestibular pathway (Body Part, Organ, or Organ Component)\tPRCA1 (Endoribonuclease Gene)\tGCIG Rustin Ovarian Cancer 2011 Oncology Response Criteria (Intellectual Product)\tUT (Geographic Area)\tIsomerase, Methylmalonyl-CoA (Enzyme)", + "output": "PRCA1 (Endoribonuclease Gene)" + }, + { + "input": "Definition: Rule described as an axiom that indicates whether the subject is allowed to transition to an element of a trial, other than the next element in the previously determined sequence.\nConcepts: transition rule (Idea or Concept)\tSpecial Purpose Domain (Intellectual Product)\tMCM8 Gene (Gene or Genome)\tPhytosteroid (Organic Chemical)\tcycloheximide transmembrane transporter activity (Molecular Function)", + "output": "transition rule (Idea or Concept)" + }, + { + "input": "Definition: something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated\nConcepts: Grade 1 Hypoparathyroidism, CTCAE (Hypoparathyroidism, CTCAE)\tAntibody Ki-67 Staining Method (Laboratory Procedure)\trPDGF (Recombinant Growth Factor)\tThapsia L., 1753 (Daucinae)\tAdhesive Strips, Multipurpose (Adhesive Strips)", + "output": "Grade 1 Hypoparathyroidism, CTCAE (Hypoparathyroidism, CTCAE)" + }, + { + "input": "Definition: something described as the membrane surrounding the outer segment of a vertebrate photoreceptor.\nConcepts: Sydney crease (Anatomical Abnormality)\tipatasertib (Pharmacologic Substance)\tphotoreceptor outer segment membrane (Cell Component)\tElevated circulating serine levels (Finding)\tRecurrent Hepatosplenic T-Cell Lymphoma (Recurrent Aggressive Non-Hodgkin Lymphoma)", + "output": "photoreceptor outer segment membrane (Cell Component)" + }, + { + "input": "Definition: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen described as catalysis of the reaction: beta-carotene + O2 <=> 10'-apo-beta-carotenal + beta-ionone.\nConcepts: Lack of Energy Frequency (Clinical or Research Assessment Question)\timmune response to tumor cell (Immune response)\tStraight sinus (Tributary of confluence of sinuses)\tbeta,beta-carotene-9',10'-cleaving oxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tADCS-ADL MCI - Clean Room (ADCS-ADL MCI Questionnaire Question)", + "output": "beta,beta-carotene-9',10'-cleaving oxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)" + }, + { + "input": "Definition: something described as implantable electrocardiographs designed for recording the variations of the electric potential caused by the electrical activity of the heart muscle only for a pre-established, relatively short period of time (typically less than one hour), and then record again on the same memory erasing the previous information (i.e., loop recording). These recorders are usually leadless devices implanted in the chest that include two or more electrodes on the surface of the recorder; they can detect and record arrhythmia episodes lasting several minutes either automatically and/or after patient activation. The information can be transferred to a patient-operated device that allows the telemetric communication of the stored data to the physician's office, usually through standard telephone lines. A programmer-tester device used to set up the recorders at the time of implantation and to save or retrieve the recorder information later is also available. The recorders are mainly used in patients who have syncope or presyncope events and/or cardiac arrhythmia. Implantable loop-recording ECGs are not intended for a real-time assessment of the electrocardiogram or other cardiac conditions.\nConcepts: adult soft tissue sarcoma, recurrent (Neoplastic Process)\tGlottic Carcinoma pTis TNM Finding v8 (Glottic Cancer Pathologic Primary Tumor TNM Finding v8)\tAmbulatory Electrocardiographs, Loop-Recording, Implantable (Medical Device)\tBGB A333 (Pharmacologic Substance)\tPMS1 Protein Homolog 2 Loss of Nuclear Expression (Loss of Nuclear Expression)", + "output": "Ambulatory Electrocardiographs, Loop-Recording, Implantable (Medical Device)" + }, + { + "input": "Definition: Urine protein described as an abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.\nConcepts: SEXUALLY MATURE (Mature)\tAfghan Hound (Dog family)\t1,4 Diazacyclohexane (Piperazine and piperazine derivative)\tProtein, Bence Jones (Immunologic Factor)\tHeterocyclic compounds (Organic Chemical)", + "output": "Protein, Bence Jones (Immunologic Factor)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of bone cancer, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.\nConcepts: Bone Cancer Pathologic Distant Metastasis TNM Finding v8 (Finding)\tSocial norms, practices and ideologies (CHAPTER 4 ATTITUDES)\tAcide Nalidixico (urinary tract antibacterial agents)\tObstructions, Bile Duct (Biliary tract structure)\tabsence; status (Epilepsy and recurrent seizures)", + "output": "Bone Cancer Pathologic Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Natural Phenomenon or Process described as phenomena originating at the interface of material.\nConcepts: Interfacial Phenomenon (Physical Phenomenon or Property)\tReceptor Regulated Smad Proteins (Phosphoproteins)\tGeneral Practitioner (Medical practitioner)\tSDTM-DOBSTLOC (Unused Subset Concept)\tOral Cancer Overexpressed 2 Gene (Gene or Genome)", + "output": "Interfacial Phenomenon (Physical Phenomenon or Property)" + }, + { + "input": "Definition: something described as a benign exophytic neoplasm that arises from the oropharynx. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium.\nConcepts: D-fructose-6-phosphate D-erythrose-4-phosphate-lyase (phosphate-acetylating) activity (Molecular Function)\tAdult Salivary Gland Carcinoma (Salivary gland carcinoma)\tOropharyngeal squamous papilloma (Neoplastic Process)\tAspilia Thouars (Heliantheae)\tStructure of right pulmonary vein (Right thorax structure)", + "output": "Oropharyngeal squamous papilloma (Neoplastic Process)" + }, + { + "input": "Definition: something described as stage IIIB includes: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0). T4: Tumor of any size with direct extension to the chest wall and/or to the skin (ulceration or macroscopic nodules); invasion of the dermis alone does not qualify as T4. N0: No regional lymph node metastasis is identified or isolated tumor cell clusters (ITCs) are identified only. N1: Tumor with micrometastases; or metastases in 1-3 axillary lymph nodes; and/or clinically negative internal mammary nodes with micrometastases or macrometastases by sentinel lymph node biopsy. N2: Tumor with metastases in 4-9 axillary lymph nodes; or positive ipsilateral internal mammary lymph nodes by imaging in the absence of axillary lymph node metastases. M0: No clinical or radiographic evidence of distant metastases. Imaging studies are not required to assign the M0 category.\nConcepts: Catheter site (Spatial Concept)\tAnatomic Stage IIIB Breast Carcinoma AJCC v8 (Neoplastic Process)\tlateral mesoderm cell fate determination (Cell Function)\tClinical Endpoint BE Studies v1.0 (FDA Technical Specification Name and Version)\tmale anatomical structure morphogenesis (Organism Function)", + "output": "Anatomic Stage IIIB Breast Carcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Body Substance described as white liquid secreted by the human mammary glands; it contains proteins, sugar, lipids, vitamins, and minerals.\nConcepts: Symptoms (Disorder Characteristics)\tSarcomatous Intrahepatic Cholangiocarcinoma (Intrahepatic Cholangiocarcinoma)\tSYSTEM,TEST,ANTIBODIES,B2 - GLYCOPROTEIN I (Medical Device)\tHuman Milk (Body Substance)\tGenu valgum (Limb structure)", + "output": "Human Milk (Body Substance)" + }, + { + "input": "Definition: Carcinoma, Neuroendocrine described as the reemergence of neuroendocrine carcinoma after a period of remission.\nConcepts: inter-Golgi transport vesicle membrane (Cell Component)\tAutoimmune Status (Immune response)\tRecurrent Neuroendocrine Carcinoma (Recurrent Malignant Endocrine Neoplasm)\tPyrus americanus, homeopathic preparation (Organic Chemical)\tdorsal gray commissure (Body Space or Junction)", + "output": "Recurrent Neuroendocrine Carcinoma (Recurrent Malignant Endocrine Neoplasm)" + }, + { + "input": "Definition: Skeletal muscle structure of thorax described as a large muscle of the axial skeleton, with origin from the first through the eighth or ninth rib, and insertion on the scapula, which is responsible for multiple arm movements, including anteversion of the arm, protraction of the scapula, and stabilization of the scapula against the thoracic wall.\nConcepts: Micrococcaceae (Bacterium)\tPSMG2 (Gene or Genome)\tSerratus Anterior Muscle (Scapular region of back)\t5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity (Genetic Function)\tMilligram per Vial (Quantitative Concept)", + "output": "Serratus Anterior Muscle (Scapular region of back)" + }, + { + "input": "Definition: something described as using midwifery assessment methods in a comprehensive, 60-minute, out-of-office meeting to assess the health status of a new midwifery client to develop a midwifery treatment plan.\nConcepts: regulation of substance P secretion (regulation of peptide hormone secretion)\tComprehensive new out-of-office 60 minutes midwifery intake (Remote location new client without ICD diagnosis)\tMEKK1 (Gene or Genome)\tContrast radiol lymphatics NOS (Radiographic procedure on cardiovascular system)\tInfant Assessment (Age Appropriate Screening)", + "output": "Comprehensive new out-of-office 60 minutes midwifery intake (Remote location new client without ICD diagnosis)" + }, + { + "input": "Definition: something described as immunoassay reagents intended to be used in the performance of quantitative analysis of body fluids (typically serum) to determine the level of the protein Ccystatin C. Determination of cystatin C level in serum provides its greatest utility in the detection of small to moderate decrease in kidney function (e.g., by giving an estimate of the glomerular filtration rate, [GFR]).; hHigh levels of this protein in serum are also related to general health status and to a variety of cardiac and liver diseases.\nConcepts: RUBINSTEIN-TAYBI SYNDROME 2 (Disease or Syndrome)\tCRYPTOSPORIDIUM SPP. (Medical Device)\tLaboratory Test Fasting Status (Qualitative Concept)\tCDKN2D Gene (Gene or Genome)\tCystatin C Immunoassay Determination Reagents (Medical Device)", + "output": "Cystatin C Immunoassay Determination Reagents (Medical Device)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Young Child Parent Report - In the past 7 days, how much of a problem has this been for your child: My child gets hurt accidentally.\nConcepts: Epidermal Growth Factor Receptor Negative (Laboratory or Test Result)\t8q24.1 (Chromosome band)\tMEK-1/MEKK-1 inhibitor E6201 (Antineoplastic Enzyme Inhibitor)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Get Hurt Accidentally (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)\tlumbosacral region (Spinal Region)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Get Hurt Accidentally (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.\nConcepts: regulation of cellular metabolism (regulation of metabolism)\tIVD Panels, Human Genetics, Eye Disorder, Retinopathy, Comprehensive (IVD Panels, Human Genetics, Eye Disorder)\tVery Hard to Extremely Hard Exertion (Intellectual Product)\tBeta Thalassemia Plus Structural Variants (Disease or Syndrome)\tFunctional Assessment of Cancer Therapy-Kidney Symptom Index-Disease-Related Symptoms Version 4 Questionnaire Test Code (CDISC Questionnaire Terminology)", + "output": "regulation of cellular metabolism (regulation of metabolism)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: chlorophyllide a + NADPH + O2 + 2 H+ = 7-hydroxychlorophyllide a + NADP+ + H2O.\nConcepts: N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide (Organic Chemical)\tBACTEROIDES FRAGILIS GROUP (Bacteroides)\tprinting (Publishing)\tchlorophyllide-a oxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen)\tMetastatic Pancreatic Adenocarcinoma (Adenocarcinoma, metastatic)", + "output": "chlorophyllide-a oxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen)" + }, + { + "input": "Definition: cytoplasmic ribonucleoprotein granule described as a ribonucleoprotein complex found in the cytoplasm of male germ cells, composed of exceedingly thin filaments that are consolidated into a compact mass or into dense strands of varying thickness that branch to form an irregular network. Contains mRNAs, miRNAs, and protein components involved in miRNA processing (such as Argonaute proteins and the endonuclease Dicer) and in RNA decay (such as the decapping enzyme DCP1a and GW182).\nConcepts: ANOSCOPE, NON-POWERED (Medical Device)\tclear cell sarcoma of the kidney (Sarcoma - category)\t2 (Body Location or Region)\tchromatoid body (Cell Component)\tFinger Flexors (Body Part, Organ, or Organ Component)", + "output": "chromatoid body (Cell Component)" + }, + { + "input": "Definition: Biologic Function described as any process that modulates the frequency, rate or extent of granzyme A production.\nConcepts: Technical Contact (Professional or Occupational Group)\tBenzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4-dimethoxy-alpha-(1-methylethyl)- (Organic Chemicals)\tregulation of granzyme A production (regulation of production of molecular mediator of immune response)\tGlycine Cleavage System Complex (Amino Acid Oxidoreductases)\tMHC class Ib protein complex assembly (Molecular Function)", + "output": "regulation of granzyme A production (regulation of production of molecular mediator of immune response)" + }, + { + "input": "Definition: Emotional support described as actions performed to console, restore, or promote spiritual health\nConcepts: Spiritual Support (Spiritual Therapies)\tLoss of or Failure to Bond (Finding)\tGrade 2 Pancreatic duct stenosis (Pancreatic Duct Stenosis, CTCAE)\tMeningocele, cerebral (Congenital anomaly of brain)\tNINHYDRIN, NITROGEN (Indicator, Reagent, or Diagnostic Aid)", + "output": "Spiritual Support (Spiritual Therapies)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) If yes, which best describes his/her awareness of the meeting ahead of time.\nConcepts: Clinical Studies (environment of study)\tToxocarosis (Helminthiasis, Animal)\tALLFAM (Gene or Genome)\tADCS-ADL - Description of Awareness of Appointment Ahead of Time (ADCS-ADL Questionnaire Question)\tTapentadol-containing product (Drug pseudoallergen by function)", + "output": "ADCS-ADL - Description of Awareness of Appointment Ahead of Time (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: Cell Function described as the directed movement of L-tryptophan across a membrane.\nConcepts: Neutrophil count NOS (White blood cell test)\tTumor DNA (DNA)\tL-tryptophan transmembrane transport (L-alpha-amino acid transmembrane transport)\tdown regulation of signal transduction in extracellular region (Molecular Function)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults - Do Not Have Equipment Need (Intellectual Product)", + "output": "L-tryptophan transmembrane transport (L-alpha-amino acid transmembrane transport)" + }, + { + "input": "Definition: Gene or Genome described as human IGF2 wild-type allele is located in the vicinity of 11p15.5 and is approximately 15 kb in length. This allele, which encodes insulin-like growth factor II protein, plays a role in cellular growth, development, and mitogenesis.\nConcepts: up regulation of fusion of virus membrane with host plasma membrane (positive regulation of viral entry into host cell)\tChromosome 11 Open Reading Frame 43 Gene (IGF2 gene)\tacetyl group (Molecular Structure)\thsa-mir-150 (Gene or Genome)\tvaline (Branched chain organic acid disorder marker)", + "output": "Chromosome 11 Open Reading Frame 43 Gene (IGF2 gene)" + }, + { + "input": "Definition: something described as human NFIL3 wild-type allele is located in the vicinity of 9q22 and is approximately 15 kb in length. This allele, which encodes nuclear factor interleukin-3-regulated protein, is involved in the regulation of gene transcription.\nConcepts: BLACK SOUTH AMERICAN (Population Group)\tTamarindus L., 1753 (Amherstieae)\tNFIL3 wt Allele (Gene or Genome)\tContrast Media Conservation Sets (Medical Device)\tAdministration procedure (ICD-10 Procedure Coding System)", + "output": "NFIL3 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as a prodrug of the monophosphate (MP) form of the antimetabolite cytarabine (araCMP), an analogue of cytidine with a modified sugar moiety (arabinose instead of ribose), with potential antineoplastic activity. Upon administration of the cytarabine MP prodrug MB07133, the targeting moiety of this agent specifically delivers the cytarabine moiety to the liver. In turn, araCMP is selectively converted to araC triphosphate (araCTP) by a liver kinase, where it binds to and competes with cytidine for incorporation into DNA, thereby inhibiting DNA polymerase, and DNA synthesis. This leads to the inhibition of tumor cell proliferation and destruction of liver cancer cells. The liver is not able to convert araC into araCMP; araCMP is not converted into araCTP in tissues other than the liver. This enhances efficacy and minimizes systemic toxicity.\nConcepts: NAPROXEN (naproxen)\tBiological Working Bank or Primary Stock Characterized Indicator (Finding)\tMB07133 (Pharmacologic Substance)\tFGF (Growth Substances)\t17beta-HSD type 2, human (Enzyme)", + "output": "MB07133 (Pharmacologic Substance)" + }, + { + "input": "Definition: Fibrinolytic system factor described as heterogeneous group of proteolytic enzymes that convert plasminogen to plasmin; concentrated in the lysosomes of most cells and in the vascular endothelium, particularly in the vessels of the microcirculation.\nConcepts: AD (Intellectual Product)\tpolyamine transmembrane transport (Cell Function)\tC-methyltransferase activity (methyltransferase activity)\t12: 11958382-111998553 (Chromosome 12 Physical Location)\tPlasminogen activators (Blood Coagulation Factor)", + "output": "Plasminogen activators (Blood Coagulation Factor)" + }, + { + "input": "Definition: Sarcoma of the Orbit Pathologic Primary Tumor TNM Finding v7 described as sarcoma of the orbit with tumor measuring more than 15 mm in greatest dimension without invasion of globe or bony wall.\nConcepts: Pregnancy, Extrauterine (Disorder of pelvis)\tNeurilemmoma of Hypoglossal Nerve (Neoplastic Process)\tSarcoma of the Orbit pT2 TNM Finding v7 (Finding)\tvital lung capacity (Dynamic lung volume)\tIrritable with Other People due to Problems with Teeth, Dentures or Mouth (Findings-Based Question)", + "output": "Sarcoma of the Orbit pT2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Leukocyte Abnormalities, General and NEC described as a progressive, proliferative disease of blood cells, originating from myeloid or lymphoid stem cells.\nConcepts: protein-lipid complex assembly (protein-containing complex assembly)\tBRUSH, BIOPSY, GENERAL & PLASTIC SURGERY (Medical Device)\tRecord, Hospital (Records)\tCSPTESEV (Finding)\tChronic leukaemia [obs] (leukemia)", + "output": "Chronic leukaemia [obs] (leukemia)" + }, + { + "input": "Definition: Protein-tyrosine kinase inhibitor described as an oral small molecule inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (InsR) tyrosine kinases with potential antineoplastic activity. Dual IGF-IR/InsR inhibitor BMS-754807 binds reversibly to and inhibits the activities of IGF-1R and InsR, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R and InsR tyrosine kinases, overexpressed in a variety of human cancers, play significant roles in mitogenesis, angiogenesis, and tumor cell survival.\nConcepts: autologous HPV-16/18 E6/E7-specific TGF-beta-resistant T lymphocytes (therapeutic autologous lymphocytes)\tCreatinine Increased (Investigations, CTCAE)\tBMS-754807 (Pharmacologic Substance)\tUrinary Retention Care (Procedure with a clinical finding focus)\tSuperfic cervical lymph node (Body Part, Organ, or Organ Component)", + "output": "BMS-754807 (Pharmacologic Substance)" + }, + { + "input": "Definition: Manufactured Object described as any of six international prizes awarded annually for outstanding work in physics, chemistry, physiology or medicine, literature, economics and the promotion of peace.\nConcepts: Necrosis, neoplasm (General Qualifier)\tPIE (Other disorders of lung)\tganetespib (HSP90 Inhibitor)\tNobel prizes (Awards and Prizes)\tHDCL (Kidney Function Tests)", + "output": "Nobel prizes (Awards and Prizes)" + }, + { + "input": "Definition: Eye part described as the 60 to 80 radiating pigmented ridges that form a frilled circle around the eye lens behind the iris.\nConcepts: Sulcus precentralis inferior (Set of subarachnoid sulci)\tCD256 (Gene or Genome)\tCDISC Terminology (Terminology Subset)\tCiliary processes set (Region of corona ciliaris)\tNPF receptor activity (Molecular Function)", + "output": "Ciliary processes set (Region of corona ciliaris)" + }, + { + "input": "Definition: Disorder of tonsil AND/OR adenoid described as increase in size of the tonsils, small collections of lymphoid tissue facing into the aerodigestive tract on either side of the back part of the throat.\nConcepts: American Cockroach IgE AB RAST Score (Laboratory Procedure)\tINSULINOMA-GLUCAGONOMA PROTEIN 20 (Signaling Pathway Gene)\tenlargement tonsils (Oral cavity)\tEpithelial Stromal Interaction 1 wt Allele (Gene or Genome)\tU-13C-Lactate (Radioconjugate)", + "output": "enlargement tonsils (Oral cavity)" + }, + { + "input": "Definition: Anatomic Variant described as anatomical structure present before birth.\nConcepts: Performance Status Scale Timing Not Applicable (Finding)\tDevelopmental structure (Anatomic Variant)\tMOUTH DRY (Oral cavity)\tPPP - Pancreatic polypeptide (Neuropeptides)\tAnti Angiogenetic Agents (Ophthalmic Agents)", + "output": "Developmental structure (Anatomic Variant)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror).\nConcepts: receptor tyrosine kinase-like orphan receptor binding (Molecular Function)\tmale meiotic nuclear division (cellular process involved in reproduction in multicellular organism)\tUnilateral sacral extension (Unilateral clinical finding)\tFamotine Hydrochloride (Antiviral Agents)\tCOX6C gene (Protein Complex Subunit Gene)", + "output": "receptor tyrosine kinase-like orphan receptor binding (Molecular Function)" + }, + { + "input": "Definition: something described as human CYP2C19*6 allele is located within 10q24.1-q24.3 and is approximately 90 kb in length. This allele, a variant form of the CYP2C19 wild-type allele, encodes cytochrome P450 2C19*6 protein. The CYP2C19*6 allele exhibits a clinically-relevant SNP (c.395G>A) in exon 3 that results in a R132Q coding change. This alteration in protein sequence abolishes the enzymatic activity of the cytochrome P450 2C19*6 protein.\nConcepts: Sum of Longest Diameters (Sum)\tCYP2C19*6 (CYP2C19 gene)\tpeptidyl-lysine crotonylation (Molecular Function)\tBone marrow transplant, not otherwise specified (Procedures on Bone Marrow)\tArch trunk position (Finding)", + "output": "CYP2C19*6 (CYP2C19 gene)" + }, + { + "input": "Definition: Structure of long bone described as one of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist.\nConcepts: Transforming Growth Factor-Beta Family Gene (Gene or Genome)\tulna (Skeletal bone)\tFevers, Uveoparotid (Iris and uveal tract infections, irritations and inflammations)\tN-glycan fucosylation (Molecular Function)\tStage IIC (Stage level 2)", + "output": "ulna (Skeletal bone)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as phosphatidylinositol 3-kinase regulatory subunit beta (728 aa, ~82 kDa) is encoded by the human PIK3R2 gene. This protein is involved in the modulation of both tyrosine phosphorylation and signal transduction.\nConcepts: Phosphatidylinositol 3-Kinase 85 kDa Regulatory Subunit Beta (Regulatory Protein)\tRecurrent Primary Cutaneous (Skin) Lymphoma (Primary cutaneous lymphoma)\tcyclic purine nucleotide metabolism (cyclic nucleotide biosynthetic process)\tModified-release capsule, hard (Biomedical or Dental Material)\tType 1 Diabetes Findings About Test Name (CDISC SDTM Terminology)", + "output": "Phosphatidylinositol 3-Kinase 85 kDa Regulatory Subunit Beta (Regulatory Protein)" + }, + { + "input": "Definition: Intervals of hours described as every ten hours.\nConcepts: IIP (Inflammation of specific body systems)\tnegative regulation of thymic T cell differentiation (negative regulation of T cell differentiation)\tEvery 10 hours (Schedule Frequency)\tSevere Combined Immune Deficiency (Combined immunodeficiency)\tPast (Temporal Concept)", + "output": "Every 10 hours (Schedule Frequency)" + }, + { + "input": "Definition: Protein-Serine-Threonine Kinases described as serine/threonine-protein kinase PLK3 (646 aa, ~72 kDa) is encoded by the human PLK3 gene. This protein is involved in protein phosphorylation and cell cycle regulation.\nConcepts: Polo-Like Kinase 3 (Protein-Serine-Threonine Kinases)\tFSHB Gene (Protein Complex Subunit Gene)\tProgesterone Receptor Positive by Immunohistochemistry 1-9 Percent (Progesterone Receptor Positive by Immunohistochemistry)\tLow arginine levels in cerebrospinal fluid (Finding)\thepatic (Topographical modifier)", + "output": "Polo-Like Kinase 3 (Protein-Serine-Threonine Kinases)" + }, + { + "input": "Definition: Temporal Concept described as the date of the tumor reoccurrence after the initial treatment.\nConcepts: Ganglion ciliare (Soft tissues of orbit)\tN-Bak Protein (Amino Acid, Peptide, or Protein)\tCounts per Minute (counts)\tDate of Tumor Reoccurrence After Initial Treatment (Temporal Concept)\tmagnetis polus articus/north (Homeopathic remedies letter M)", + "output": "Date of Tumor Reoccurrence After Initial Treatment (Temporal Concept)" + }, + { + "input": "Definition: Percent Recovered Infinity Predicted described as the percentage of the administered dose that is recovered from the specimen type specified in PPSPEC extrapolated to infinity, calculated using the predicted value of the last non-zero concentration, divided by the surface area.\nConcepts: HIV-2 Glycoprotein 36 Antibody (HIV-2 Antibody Measurement)\tRCPCIFPS (Percent Recovered Infinity Predicted)\tNeurofibromin S2309Cfs*10 (NF1 Protein Variant)\tfumiquinazoline C catabolism (fumiquinazoline C metabolic process)\tOligozoospermia (MALE REPRODUCTIVE FUNCTIONS AND SYMPTOMS)", + "output": "RCPCIFPS (Percent Recovered Infinity Predicted)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a condyloid synovial joint within the third digit of the foot articulating metatarsal with the proximal phalanx.\nConcepts: Stage IIIA Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8 (Stage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8)\tHepatocellular carcinoma recurrent (Recurrent Primary Malignant Neoplasm)\tMaintenance of blood pressure (Blood pressure functions)\tSalivary Acidic Protein 1 (Amino Acid, Peptide, or Protein)\tMTP3 (Metatarsophalangeal joint structure)", + "output": "MTP3 (Metatarsophalangeal joint structure)" + }, + { + "input": "Definition: something described as cervical carcinoma with involvement of pelvic and/or para-aortic lymph nodes, irrespective of tumor size and extent (with r and p notations).\nConcepts: Spine Surgery Burs (Burs, Surgical)\tRPQ01-Light Sensitivity/Bright Light (RPQ Questionnaire Question)\tIntracervical (Intraabdominal Route of Drug Administration)\tAdditional Surgery for New Metastatic Tumor Event Not Evaluated (CPTAC Responses)\tStage IIIC Cervical Cancer FIGO 2018 (Neoplastic Process)", + "output": "Stage IIIC Cervical Cancer FIGO 2018 (Neoplastic Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.\nConcepts: Lacrimal punctum plug (ophthalmic preparation)\t1,2-dehydroreticulinium ion reductase activity (Molecular Function)\tLow blood pressure, not hypotension (Sign or Symptom)\tapolipoprotein C (Apolipoproteins)\tNPI - Seem Sad or Depressed (NPI Questionnaire Question)", + "output": "apolipoprotein C (Apolipoproteins)" + }, + { + "input": "Definition: MIR30A gene described as the human MIR30A wild-type allele is located in the vicinity of 6q13 and is approximately 70 bases in length. This allele, which encodes MIR30A pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with the development of glomerular disease.\nConcepts: Increased insoluble fiber diet (High residue diet)\tLacrimal Apparatus (Ocular adnexa structure)\tspindle microtubule (Cell Component)\tmiRNA30A (Gene or Genome)\tPlanned Activity Repeat Frequency Ratio (Quantitative Concept)", + "output": "miRNA30A (Gene or Genome)" + }, + { + "input": "Definition: Transport Protein Gene described as this gene plays a role in folate transport.\nConcepts: Dense regular elastic tissue (Small intestine submucosa)\tThiocapsa roseopersicina (Bacterium)\tEnterotoxigenic E. coli (Diarrheagenic Escherichia coli)\tStructure of proximal phalanx of foot (Body Part, Organ, or Organ Component)\treduced folate carrier 1 (Gene or Genome)", + "output": "reduced folate carrier 1 (Gene or Genome)" + }, + { + "input": "Definition: something described as a disorder characterized by a dysrhythmia that originates in the ventricles.\nConcepts: POEMS (Multiple Myeloma)\tSocial Facilitations (Social Behavior)\tSIOP Staging System (Staging system)\tVentricular Arrhythmia, CTCAE 5 (Cardiac Disorders, CTCAE)\tOdontoblasts (General ecto-epithelial cell)", + "output": "Ventricular Arrhythmia, CTCAE 5 (Cardiac Disorders, CTCAE)" + }, + { + "input": "Definition: Central Nervous System Infection described as a progressive demyelination within the central nervous system associated with reactivation of a latent JC virus infection.\nConcepts: GAIA Level 1 Second Trimester Spontaneous Abortion (GAIA Spontaneous Abortion Level of Diagnostic Certainty)\tPMLE - Progressive multifocal leukoencephalopathy (Demyelinating disorders NEC)\tLymphoma of gastrointestinal tract (Non-Hodgkin's lymphomas NEC)\tInfant, Preterm (Age Group)\tDisease Response Evaluator Identifier (Intellectual Product)", + "output": "PMLE - Progressive multifocal leukoencephalopathy (Demyelinating disorders NEC)" + }, + { + "input": "Definition: Androgens described as a natural or synthetic steroid that promotes bone and muscle growth\nConcepts: Soft Tissue Sarcoma Pathologic Primary Tumor TNM Finding v7 (Finding)\tUpper/Lower Limb Plethysmographs (Plethysmograph)\tanabolics steroids (Endocrine in tox)\tPerformedObservationResult.valueNullFlavorReason (Idea or Concept)\tFrontotemporal (Spatial Concept)", + "output": "anabolics steroids (Endocrine in tox)" + }, + { + "input": "Definition: Fibrinolytic Agents described as a pyrazolinone derivative with potential antimetastatic activities. Nafazatrom, originally developed as an antithrombotic agent, inhibits the key prostaglandin catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase, which prolongs the biological half-life of prostacyclin (prostaglandin I2; PGI2) and prevents intravascular coagulation. This agent also serves as a reducing cofactor with the hydroperoxidase moiety of cyclooxygenase and accelerates the conversion of arachidonic acid into precursors of PGI2. An elevated level of PGI2 prevents aggregation of platelets; subsequently it decreases the formation of tumor cell-platelet aggregates as well as their sequestration in blood vessels, which is an important initiating step in the development of metastasis.\nConcepts: benzoate cis-diol dehydrogenase activity (Molecular Function)\tcare communication (Health Care Activity)\tHave Trouble Feeling Shape of Small Objects in Hand (Findings-Based Question)\tNAFAZATROM (Pharmacologic Substance)\tAmyotrophy involving the extremities (MUSCLE SOFT, TISSUE)", + "output": "NAFAZATROM (Pharmacologic Substance)" + }, + { + "input": "Definition: Research or Clinical Assessment Tool described as a rating scale included in the Behavior Assessment System for Children that measures the subject's ability to follow through or complete simple daily tasks.\nConcepts: Multifocal Lesion (Lesion by Focality)\tActivities of Daily Living Scale (Intellectual Product)\tInhalants profile for 47 inhalants each test (Laboratory Procedure)\tRight posterolateral middle peripheral zone of prostate (Body Part, Organ, or Organ Component)\tThrombin-antithrombin III complex Assay (Thrombophilia screening)", + "output": "Activities of Daily Living Scale (Intellectual Product)" + }, + { + "input": "Definition: Chelating Agents described as the sodium salt of gluconic acid with chelating property. Sodium gluconate chelates and forms stable complexes with various ions, preventing them from engaging in chemical reactions.\nConcepts: Lamp, Gullstrand's Slit (Medical Device)\tDigital Image-FFPE B-Cell (CD20) Slide (Intellectual Product)\tamnioserosa maintenance (Organism Function)\tSodium Gluconate (Chelating Agents)\tEntire body space (Anatomical space structure)", + "output": "Sodium Gluconate (Chelating Agents)" + }, + { + "input": "Definition: Transferase Gene described as this gene is involved in the regulation of the uric acid cycle.\nConcepts: TESTIS/EPIDIDYMIS (Tissue specimen)\tPsychology, Religion (Idea or Concept)\telectrical impedance (electrical property)\tMycosis Fungoides and Sezary Syndrome TNM Finding v8 (Finding)\tornithine transcarbamylase (Gene Mutation)", + "output": "ornithine transcarbamylase (Gene Mutation)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as procedures which rely upon movement and manipulation of the body.They focus primarily on the structures and systems of the body, including the bones and joints, the soft tissues, and the circulatory and lymphatic systems\nConcepts: Primary Cutaneous Intravascular Large B-Cell Lymphoma (Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other)\tLarson Regimen (Therapeutic or Preventive Procedure)\tepigastrium (ABDOMEN INCLUDING PERITONEUM AND RETROPERITONEUM)\tpositive regulation of basement membrane assembly involved in embryonic body morphogenesis (positive regulation of embryonic development)\tManipulative and Body-Based Intervention Procedure (Therapeutic or Preventive Procedure)", + "output": "Manipulative and Body-Based Intervention Procedure (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Midbrain nucleus described as a pinkish-yellow portion of the midbrain situated in the rostral mesencephalic tegmentum. It receives a large projection from the contralateral half of the CEREBELLUM via the superior cerebellar peduncle and a projection from the ipsilateral MOTOR CORTEX.\nConcepts: Oropharyngeal route (Respiratory tract route)\tRN - Red nucleus (Midbrain structure)\tTYRP (Tumor Antigens)\tpositive regulation of interleukin-35-mediated signaling pathway (regulation of interleukin-35-mediated signaling pathway)\tDesmoplastic Fibroma (Benign fibromatous neoplasm - category)", + "output": "RN - Red nucleus (Midbrain structure)" + }, + { + "input": "Definition: diphosphoric monoester hydrolase activity described as catalysis of the reaction: 2-cis,6-trans,10-trans-geranylgeranyl diphosphate + H2O <=> (13E)-labda-7,13-dien-15-ol + diphosphoric acid.\nConcepts: Dermacentroxenus rickettsii (spotted fever group)\tFAC016-Trouble Meeting Needs of Family (FACT-L Version 4 Questionnaire Question)\t(13E)-labda-7,13-dien-15-ol synthase activity (diphosphoric monoester hydrolase activity)\tactualIndicator (Qualitative Concept)\tSelf-Conscious if Grooming is Wrong (Findings-Based Question)", + "output": "(13E)-labda-7,13-dien-15-ol synthase activity (diphosphoric monoester hydrolase activity)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a radioimmunoconjugate consisting of a monoclonal antibody directed against the human carcinoembryonic antigen (CEA) conjugated with the radioisotope yttrium 90 (Y-90) via the chelator tetra-azacyclododecanetetra-acetic acid (DOTA) with potential antineoplastic activity. The antibody moiety of yttrium Y 90 DOTA anti-CEA monoclonal antibody M5A binds to cells expressing the CEA antigen. Upon cellular internalization, this agent selectively delivers a cytotoxic dose of beta radiation. CEA, a tumor associated antigen, is overexpressed in many cancer types, including gastrointestinal, breast, non-small cell lung, and thyroid cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C77853\" active clinical trials using this agent.\nConcepts: Euodia (Plant)\tADL0318N (Intellectual Product)\tY90-DOTA-M5A (Amino Acid, Peptide, or Protein)\tElbow Extensors (Body Part, Organ, or Organ Component)\tDDCYD (Immunomodulators)", + "output": "Y90-DOTA-M5A (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of ubiquitin transferase activity.\nConcepts: regulation of ubiquitin-protein transferase activity (Ubiquitination Regulation Protein)\tRas Homolog Family Member U wt Allele (Gene or Genome)\tBasal cell hamartoma with follicular differentiation (Acanthoma)\tCritical care (Care provision regimes)\tLeft Cardiac Ventricular Pacing Malfunction (Event)", + "output": "regulation of ubiquitin-protein transferase activity (Ubiquitination Regulation Protein)" + }, + { + "input": "Definition: Nerve Tissue described as neural tissue which consists of neuron cell bodies, neuron processes, and neuroglia within a peripheral ganglion. Examples: Neural tissue of dorsal root ganglion, Neural tissue of celiac ganglion.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Ehrlichia Species, IgM Antibody (Medical Device)\tNeural tissue of peripheral ganglion (Tissue)\tresponse to bleomycin (response to peptide)\tBehavior Therapy, Dialectical (Therapeutic or Preventive Procedure)\tMakorin Ring Finger Protein 1 Gene (Ubiquitin-Transferase Gene)", + "output": "Neural tissue of peripheral ganglion (Tissue)" + }, + { + "input": "Definition: Immunoglobulin E measurement described as a classification of the amount of mold mix pollen IgE antibody, using the RAST (radioallergosorbent test) scoring system, in a biological specimen.\nConcepts: rF-TYR Vaccine (fowlpox virus vaccine)\tMicrobiology Susceptibility Domain (Domain)\t1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane (Iron Chelator [EPC])\tConjoint Measurement (Statistical Measurement)\tMold Mix IgE Antibody RAST Score Measurement (Immunoglobulin E measurement)", + "output": "Mold Mix IgE Antibody RAST Score Measurement (Immunoglobulin E measurement)" + }, + { + "input": "Definition: something described as severity modifier to use with CMS non-payable G-codes\nConcepts: At least 20% but less than 40% impaired, limited, or restricted (Finding)\tHIV-2 Nucleic Acid (Laboratory Procedure)\t17: 29636800-29639312 (Chromosome 17 Physical Location)\tColonoscope, device (Endoscopes)\tSoftware, Stereotactic System, Image-Guided Biopsy, Mammographic (Software, Stereotactic System, Image-Guided Biopsy)", + "output": "At least 20% but less than 40% impaired, limited, or restricted (Finding)" + }, + { + "input": "Definition: Anatomy Qualifier described as of or relating to the fold of peritoneum, or mesentery, attached to the rectum.\nConcepts: West Haven Hepatic Encephalopathy Grade 3 (West Haven Criteria - West Haven Hepatic Encephalopathy Grade)\tRNA Splice Sites (Regulatory Sequences, Ribonucleic Acid)\tMesorectal (Anatomy Qualifier)\tCD158k Antigens (Killer-Cell Immunoglobulin-Like Receptor)\tAssesses risk factors for perioperative pressure injury (Health Care Activity)", + "output": "Mesorectal (Anatomy Qualifier)" + }, + { + "input": "Definition: Functional Concept described as administration of through the diffusion of substance through a membrane in an electric field.\nConcepts: L-glutamate import across plasma membrane (amino acid import across plasma membrane)\tElectro-osmosis Route of Drug Administration (Functional Concept)\tcortical microtubule (Cell Component)\tIsolated Levocardia (Congenital cardiac malpositions and transpositions)\tINVAC-1 (Pharmacologic Substance)", + "output": "Electro-osmosis Route of Drug Administration (Functional Concept)" + }, + { + "input": "Definition: something described as a rare urogenital neoplasm with characteristics of a gland-forming epithelial neoplasm arising from paratesticular structures, typically manifesting with a palpable scrotal mass, with or without hydrocele, and/or testicular pain.\nConcepts: Okazaki fragment processing involved in mitotic DNA replication (mitotic cell cycle process)\tFactor VIII Activity Actual/Control (Laboratory Procedure)\tMelanoma of the Conjunctiva cN0a (Biopsy) TNM Finding v7 (Melanoma of the Conjunctiva Clinical Regional Lymph Nodes TNM Finding v7)\tParatesticular adenocarcinoma (Neoplastic Process)\tzd6126 (Tubulin Binding Agent)", + "output": "Paratesticular adenocarcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as an ointment that can potentially be used to treat vascular endothelial growth factor receptor (VEGFR) inhibitor (VEGFRi)-associated hand-foot skin reaction (HFSR).\nConcepts: Metastatic Gastroesophageal Junction Adenocarcinoma (Metastatic Digestive System Carcinoma)\tOncogene Protein v-cbl (Biologically Active Substance)\tLonicera pericylmenum / woodbine (Organic Chemical)\tOQL 011 (Topical Preparation)\tt(11;14) (Cell or Molecular Dysfunction)", + "output": "OQL 011 (Topical Preparation)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of matrix metalloproteinase 2 present in a sample.\nConcepts: Matrix Metalloproteinase 2 measurement (Laboratory Procedure)\tcarboplatin-Taxol-bevacizumab regimen (Regimen Used to Treat Non-Small Cell Lung Carcinoma)\t2-3 (Research Activity)\tmetapneumovirus (Virus)\tD(1A) Dopamine Receptor (Dopamine Receptor)", + "output": "Matrix Metalloproteinase 2 measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as a short, self-assessment to measure an individual's physical symptoms, emotional burden and practical concerns that could interfere with their ability to engage in cancer treatment.\nConcepts: 11: 93157096-93186102 (Chromosome 11 Physical Location)\tPBP (MED1 gene)\tCytokine Network Pathway (Molecular Function)\tDART (Research or Clinical Assessment Tool)\tANTISERUM, FLUORESCENT, CHLAMYDIA TRACHOMATIS (Medical Device)", + "output": "DART (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Glycoproteins described as glycoproteins with the electrophoretic mobility of BETA-GLOBULINS, secreted by the placental TROPHOBLASTS into the maternal bloodstream during PREGNANCY. They can be detected 18 days after OVULATION and reach 200 mg/ml at the end of pregnancy. They are associated with fetal well-being.\nConcepts: Social Communication (Social Behavior)\tAndrostane-3,17-diol, 2-(4-morpholinyl)-16-(1-(2-propen-1-yl)-1-pyrrolidiniumyl)-, 17-acetate, (2beta,3alpha,5alpha,16beta,17beta)- (Pharmacologic Substance)\tViral Hemorrhagic Fever (Hemorrhage)\tbeta 1 Globulin, Trophoblast Specific (Pregnancy Proteins)\tNaphazoline product (Vasoconstrictor Agents)", + "output": "beta 1 Globulin, Trophoblast Specific (Pregnancy Proteins)" + }, + { + "input": "Definition: something described as a group of cells located medial to the medial vestibular nucleus of the mouse ( Paxinos-2001 ).\nConcepts: TDI - Change in Magnitude of Effort (TDI Clinical Classification Question)\tnucleus of origin of efferents of the vestibular nerve (Body Part, Organ, or Organ Component)\tGRANULOMATOUS DISEASE, CHRONIC, AUTOSOMAL RECESSIVE, 1 (Disease or Syndrome)\tCAR (Amino Acid, Peptide, or Protein)\tOhmmeters (Electromechanical Devices)", + "output": "nucleus of origin of efferents of the vestibular nerve (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Metabolic disorders NEC described as enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).\nConcepts: Grade 3 Arteritis Infective, CTCAE (Finding)\tG-Protein Coupled Receptor 126 (Amino Acid, Peptide, or Protein)\tGoiter NOS (ENDOCRINE FEATURES)\tClips, Implantable, Vascular, Scalp (Clips, Implantable, Vascular)\tTIM (Gene or Genome)", + "output": "Goiter NOS (ENDOCRINE FEATURES)" + }, + { + "input": "Definition: cell migration involved in gastrulation described as the interdigitation of cells along the mediolateral axis during gastrulation.\nConcepts: regulation of skeletal muscle tissue regeneration (regulation of wound healing)\tmediolateral intercalation (Cell Function)\tLymphatic leukaemia (WHITE CELL AND RES DISORDERS)\tATPase-coupled ferric-hydroxamate transmembrane transporter activity (ATPase-coupled amide-transporter activity)\tLOCF (Quantitative Concept)", + "output": "mediolateral intercalation (Cell Function)" + }, + { + "input": "Definition: Medical Device described as device for automatic injection into embryonated eggs.\nConcepts: EFT 15min (Health Care Activity)\tIn-ovo injection device (Medical Devices)\tMetanephrine Excretion Rate (Laboratory Procedure)\tNMT1 (Amino Acid, Peptide, or Protein)\tDPDTNEG (Myocardial Contractility Measurement)", + "output": "In-ovo injection device (Medical Devices)" + }, + { + "input": "Definition: Technetium radioisotope described as a radiopharmaceutical used extensively in cholescintigraphy for the evaluation of hepatobiliary diseases. (From Int Jrnl Rad Appl Inst 1992;43(9):1061-4)\nConcepts: regulation of protein localization to centrosome (regulation of cellular protein localization)\tSeed Leave (Plant Shoots)\tDisofenin, Tc-99m (Drug allergens)\tGeneralStatisticalConsideration (Consideration)\tRFT5-dgA Immunotoxin IMTOX25 (Ricin Immunoconjugate)", + "output": "Disofenin, Tc-99m (Drug allergens)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a clinician-assessed rating of psychological and social functioning in children ages six to seventeen that was developed by Shaffer et al. in 1983. The numerical scale, which is an adaptation of the adult Global Assessment Scale (GAS) developed by Endicott et al in 1976, is scored from 0 to 100 based on behaviors and life situations that are applicable to children.\nConcepts: CGAS (Clinical or Research Assessment Questionnaire)\tConfirmed case (Finding)\tType I transferrin isoform profile (Finding)\tMedullary Thyroid Carcinoma Clinical TNM Finding v8 (Finding)\tANTISERA, FLUORESCENT, POLIOVIRUS 1-3 (Immunologic Factor)", + "output": "CGAS (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as an Austronesian language spoken by the Minangkabau people of the Indonesian province of West Sumatra, the western part of Riau Province, South Aceh Regency, and the northern part of Bengkulu and Jambi Provinces.\nConcepts: ACTR707 T-cells (therapeutic autologous lymphocytes)\tmovement of group I intron (intron homing)\tLife Experiences (Phenomenon or Process)\tKRAS1 c.37G>C (KRAS Exon 2 Mutation)\tMinangkabau Language (Language)", + "output": "Minangkabau Language (Language)" + }, + { + "input": "Definition: Central nervous system neoplasms malignant NEC described as a sarcoma arising from the brain.\nConcepts: Grade 4 Breast Infection, CTCAE (Finding)\tSarcoma of Brain (Malignant neoplasm of brain)\tCamouflages, Biological (Natural Phenomenon or Process)\tSustaining a conversation (conversation)\tnegative regulation of adenosine receptor signaling pathway (negative regulation of G protein-coupled receptor signaling pathway)", + "output": "Sarcoma of Brain (Malignant neoplasm of brain)" + }, + { + "input": "Definition: Thiosemicarbazones described as a radioconjugate consisting of a lipophilic copper(II)bis(thiosemicarbazone) labeled with the positron- and beta-emitting isotope (64)Cu with hypoxia-selective and antineoplastic activities. With a high membrane permeability and redox potential, copper Cu 64-ATSM is preferentially taken up by hypoxic cells compared to normoxic cells; the extent of retention in tissue is inversely related to the state of tissue oxygenation allowing the quantitation of tissue hypoxia by positron emission tomography (PET). In addition, the radioactive copper moiety of this agent may deliver a selective cytotoxic dose of beta radiation to hypoxic tumor cells.\nConcepts: Arsenic trihydride (Arsenicals)\tVitamin B>6< (substance) [Ambiguous] (Pyridine and pyridine derivative)\tEthylene glycol (E [Preparations])\tCu64 labeled diacetyl-bis N-(4)-methylthiosemicarbazone (Indicator, Reagent, or Diagnostic Aid)\tDRRI-2 - B: Shared Interests With Family (DRRI-2 Questionnaire Question)", + "output": "Cu64 labeled diacetyl-bis N-(4)-methylthiosemicarbazone (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: positive regulation of cytokine production described as any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.\nConcepts: negative regulation of interleukin-17A biosynthetic process (negative regulation of cytokine biosynthetic process)\tAbnormal connection of the cardiac segments (Congenital Heart Defects)\tpositive regulation of platelet-derived growth factor production (Organism Function)\tmethods staining (Miscellaneous)\tYang Yin Fu Zheng (Biologically Active Substance)", + "output": "positive regulation of platelet-derived growth factor production (Organism Function)" + }, + { + "input": "Definition: something described as a subjective score of 5 on a scale that ranges from 0: As Bad As It Can Be to 10: As Good As It Can Be.\nConcepts: Feeling Intensity Score 5 (Clinical or Research Assessment Answer)\tDistractors, Surgical, Hip (Distractors, Surgical)\tFocal Duration (Duration)\tAurora A Kinase Inhibitor LY3295668 Erbumine (Antineoplastic Enzyme Inhibitor)\tFACT-TAXANE V4 (Intellectual Product)", + "output": "Feeling Intensity Score 5 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Students, Health Occupations described as individuals enrolled in a school of nursing or a formal educational program leading to a degree in nursing.\nConcepts: HYPOPHOSPHATASIA (Disorder of phosphate, calcium and vitamin D metabolism)\t4-O-methyl-glucuronoyl methylesterase activity (Molecular Function)\tNURS STUDENT (College student)\tMulticystic Mesothelioma (Neoplasm, uncertain whether benign or malignant)\tDryas (Plant)", + "output": "NURS STUDENT (College student)" + }, + { + "input": "Definition: Genes, Regulator described as this gene may play a role in the regulation of both ion channels and ubiquitination.\nConcepts: Cathepsin K wt Allele (CTSK gene)\tNPI1-Increase in Appetite (NPI Questionnaire Question)\tdJ756N5.2 (Gene or Genome)\tUterine Ligament Tumor (Neoplastic Process)\tControlled (Finding)", + "output": "dJ756N5.2 (Gene or Genome)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as leaflet of tricuspid valve which is attached to the anterior and septal papillary muscles through the chorda tendinea of right ventricle.\nConcepts: Rare Non-Neoplastic Disorder (Rare Diseases)\tRight superolateral leaflet of tricuspid valve (Body Part, Organ, or Organ Component)\tCircuit Board Device (Manufactured Object)\tCLMFp40 binding (Molecular Function)\tCap polyposis (Intestinal polyposis syndrome)", + "output": "Right superolateral leaflet of tricuspid valve (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the Young Mania Rating Scale (YMRS) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: Abnormality of corneal epithelium (Anatomical Abnormality)\tANDA (Intellectual Product)\tCDISC Questionnaire YMRS Test Name Terminology (Unused Subset Concept)\tCOLLIMATOR, HIGH VOLTAGE, THERAPEUTIC X-RAY (Medical Device)\t20p11.2 (Chromosome band)", + "output": "CDISC Questionnaire YMRS Test Name Terminology (Unused Subset Concept)" + }, + { + "input": "Definition: Anatomical Abnormality described as presence of an additional phalanx-like bone, producing an extra, wedge-shaped bone at the base of the proximal phalanx of the third finger.\nConcepts: Hypersegmentation of proximal phalanx of third finger (Anatomical Abnormality)\tcolorectal surgeon (Biomedical Occupation or Discipline)\tGrade 1 Irritability, CTCAE (Finding)\t6,8-bis(benzylthio)octanoic acid (Pharmacologic Substance)\tIVD Test Reagent/Kits, Serology, Bacteria, Streptococcus A, Antibody, M Protein (IVD Test Reagent/Kits, Serology, Bacteria, Streptococcus Species, Antibody)", + "output": "Hypersegmentation of proximal phalanx of third finger (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as pharmacy freezers with front-opening (upright) configurations designed for storage of drugs and other pharmaceutical products at temperatures from 0 to -20 or -30 degrees Celsius (32 to -4 or -22 degrees Fahrenheit). These freezers are usually made with a corrosion-resistant (typically stainless steel) interior, minimizing the risk of adulteration, contamination, and/or corrosion of contents; the internal shelving is appropriate for storage and easy location of pharmaceutical product containers. Upright pharmacy freezers include automatic defrost capability, maintaining the temperature in the entire freezing chamber within preestablished limits during the process; they also include sensors, controls, monitors, and alarms for dependable long-term storage following pharmacy standards. A wide variety of freezer capacities and shelf configurations is available.\nConcepts: Client Computer (Manufactured Object)\tFreezers, Pharmacy, Upright (Freezers, Pharmacy)\tajmaline metabolism (Molecular Function)\t5: 131854326-131846679 (Spatial Concept)\talpha Methylnorepinephrine (norepinephrine)", + "output": "Freezers, Pharmacy, Upright (Freezers, Pharmacy)" + }, + { + "input": "Definition: Enzyme described as a deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.\nConcepts: Elevated CSF dopamine level (Abnormal CSF dopamine level)\tAiolos (Transcription factor genes)\tAmnion Epithelium Necrosis (Pathologic Function)\tlast patient in - identity (Intellectual Product)\tCYLD Protein (Tumor Suppressor Proteins)", + "output": "CYLD Protein (Tumor Suppressor Proteins)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.\nConcepts: terpene metabolic process (isoprenoid metabolic process)\tDerivation, Fermentation, Shaker Flask or Roller Bottle (Cell Culture-Based Biosynthesis)\tdeviationCategoryCode (Intellectual Product)\tClocks (Diagnostic, Therapeutic, and Research Equipment)\tnodes positives (Finding)", + "output": "terpene metabolic process (isoprenoid metabolic process)" + }, + { + "input": "Definition: Pharmacologic Substance described as an indenoisoquinoline and non-camptothecin inhibitor of topoisomerase I (Top I) with potential antineoplastic activity. Topoisomerase I inhibitor LMP400 binds to the topoisomerase I-DNA covalent cleavage complexes, and inhibits repair of single-strand DNA breaks, DNA replication, and tumor cell growth in susceptible tumor cell populations. Compared to camptothecins, indenoisoquinolines are chemically stable, produce stable Top I-DNA cleavage complexes, induce unique DNA cleavage sites and appear more resistant to multidrug efflux pumps. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90594\" active clinical trials using this agent.\nConcepts: Top1 inhibitor 400 (Topoisomerase I Inhibitors)\tVEIN, PORTAL (OTHER ABDOMINAL VEINS)\tCerebral Vein Thrombosis (Cerebral Embolism and Thrombosis)\tapocarotenoid catabolic process (apocarotenoid metabolic process)\tRegulation of Cell Death (Cell Function)", + "output": "Top1 inhibitor 400 (Topoisomerase I Inhibitors)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as COUP transcription factor 2 (414 aa, ~46 kDa) is encoded by the human NR2F2 gene. This protein is involved in the mediation of transcription.\nConcepts: Nuclear Receptor Subfamily 2 Group F Member 2 (COUP Transcription Factors)\tRADIOIMMUNOASSAY, PREGNENOLONE (Indicator, Reagent, or Diagnostic Aid)\tHemoglobin Zeta wt Allele (Gene or Genome)\tadenovirus-mediated REIC/Dkk-3 secretory protein (Immunologic Factor)\tregulation of mitotic cell cycle spindle assembly checkpoint (regulation of mitotic spindle checkpoint)", + "output": "Nuclear Receptor Subfamily 2 Group F Member 2 (COUP Transcription Factors)" + }, + { + "input": "Definition: angiotensin II described as angiotensin II derivative and antagonist used as an antihypertensive and diagnostic aid.\nConcepts: rhinencephalon (Body Part, Organ, or Organ Component)\tsnRNP U1 (Cell Component)\tsaralasin (Antihypertensive Agents)\tM520, Rat Strain (Common Rattus Norvegicus Strains)\tStoriform-Pleomorphic Malignant Fibrous Histiocytoma (Neoplasms)", + "output": "saralasin (Antihypertensive Agents)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Dactylis glomerata pollen antigen IgG4 antibody in a biological specimen.\nConcepts: ebola virus disease (Virus Diseases)\tGene targeting (Genetic Techniques)\tOrchard Grass Pollen IgG4 Measurement (Immunoglobulin measurement)\tNerves, Peripheral (Organ component cluster)\tRenal Pelvis and Ureter Cancer cM0 TNM Finding v7 (Finding)", + "output": "Orchard Grass Pollen IgG4 Measurement (Immunoglobulin measurement)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 16q\nConcepts: Gastric volvulus (Disease or Syndrome)\thuman subject (Homo sapiens)\tdownregulation of hydrogen ion translocating F-type ATPase activity (regulation of proton-transporting ATP synthase activity, rotational mechanism)\tNon-Neoplastic Connective and Soft Tissue Diseases (Connective and Soft Tissue Disorder)\t16q23.1 (Chromosome band)", + "output": "16q23.1 (Chromosome band)" + }, + { + "input": "Definition: something described as the lipid bilayer surrounding a clathrin-coated phagocytic vesicle.\nConcepts: clathrin-coated phagocytic vesicle membrane (clathrin-coated endocytic vesicle membrane)\tAntimicrobial Combination Testing Method (Microbial susceptibility tests)\tDTX2 protein, human (Amino Acid, Peptide, or Protein)\tmacula lutea (Region of optic part of retina)\tCoccidioidomycosis, unspecified (Lower respiratory tract infection fungal)", + "output": "clathrin-coated phagocytic vesicle membrane (clathrin-coated endocytic vesicle membrane)" + }, + { + "input": "Definition: something described as catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site.\nConcepts: SAP97 (Biologically Active Substance)\tsite-specific tyrosine recombinase activity (Molecular Function)\tregulation of actin filament organization (regulation of actin cytoskeleton organization)\tlenticonus (Congenital malposition of eye)\tCan you use the telephone (Findings-Based Question)", + "output": "site-specific tyrosine recombinase activity (Molecular Function)" + }, + { + "input": "Definition: Endoscopy described as an endoscopic technique that allows deep intubation of the small intestine while using a standard endoscope. An inflatable balloon attached to the endoscope's tip acts as a stabilizer and a second balloon that is advanced ahead of the endoscope acts as a pulling device.\nConcepts: Breast Carcinoma cN1mi TNM Finding v8 (Breast Cancer cN1 TNM Finding v8)\tmodulation by symbiont of host cell cycle (Cell Cycle Control)\tBalloon-Guided Endoscopy (Diagnostic Procedure)\tRecommended Storage Atmospheric Pressure (Qualitative Concept)\tCongenital Thyroid Hypoplasia (Congenital anomaly of the thyroid gland)", + "output": "Balloon-Guided Endoscopy (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as a substance intended for administration in or around the eye.\nConcepts: dorsal motor nucleus of vagus nerve morphogenesis (Morphogenesis)\t4: 55832690-55785577 (Spatial Concept)\tCephalosporins (Antibiotic)\tWright-Giemsa staining (Staining technique)\tOphthalmic Dose Form (Biomedical or Dental Material)", + "output": "Ophthalmic Dose Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: something described as an action that is deemed unsatisfactory or unacceptable.\nConcepts: UVF - Urethrovaginal fistula (Acquired urethral fistula)\tICNETAS (Laboratory Procedure)\tDisapproval (Action)\thistone H3-K36 dimethylation (peptidyl-lysine dimethylation)\tHamsters, Golden Syrian (Mesocricetus)", + "output": "Disapproval (Action)" + }, + { + "input": "Definition: NCCN-FACT FHNSI-22 Version 2 Questionnaire Question described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Head & Neck Symptom Index-22 Version 2 - I have mouth sores.\nConcepts: Childhood Pineoblastoma (pineoblastoma)\tProtein TFG/ALK Tyrosine Kinase Receptor Short Form Fusion Protein (Amino Acid, Peptide, or Protein)\tsolvent (Chemicals)\tFAC03616 (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)\tVisceral Arterial Ischemia (Finding)", + "output": "FAC03616 (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)" + }, + { + "input": "Definition: Collection Date Time described as the date and time of disease response data collection.\nConcepts: IIEF0103 (IIEF Questionnaire Question)\tRSDTC (Temporal Concept)\tSarcoma of Skin (Malignant tumor of dermis)\tCytomegaloviral dis,unspec (Infection)\tMerkel Cell Carcinoma cN3 TNM Finding v8 (Finding)", + "output": "RSDTC (Temporal Concept)" + }, + { + "input": "Definition: something described as failure to respond to two or more trials of antidepressant monotherapy or failure to respond to four or more trials of different antidepressant therapies.\nConcepts: Iodotyrosine (Hormones)\tLEC01-Sexual Assault: Not Sure (LEC-5 Standard Version Questionnaire Question)\tTreatment Resistant Depression (Major Depressive Disorder)\tMLL-SEPT5 Fusion Gene (Fusion Gene)\tQuarantines (Infectious disease prevention / control)", + "output": "Treatment Resistant Depression (Major Depressive Disorder)" + }, + { + "input": "Definition: Neoplastic Process described as stage IVB includes: T0, N3, M0. T0: No evidence of primary tumor. N3: Metastasis in a cervical lymph node larger than 6 cm in greatest dimension and ENE(-); or metastases in a single ipsilateral cervical lymph node larger than 3 cm in greatest dimension and ENE(+); or metastases in multiple ipsilateral, contralateral, or bilateral cervical lymph nodes, any size and ENE(+) in any node. M0: No distant metastasis.\nConcepts: Stage IVB Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8 (Neoplastic Process)\tGrade 1 Vaginal pain (Finding)\tGEL CHROMATOGR (Liquid Chromatography)\tPeritonsillar abscess NOS (Other and unspecified diseases of upper respiratory tract)\tWD6-Time Spend on Your Health Condition (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", + "output": "Stage IVB Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: G-Protein-Coupled Receptors described as receptor specific for delta-9- tetrahydrocannabinol and its' analogs.\nConcepts: HIGH PRESSURE LIQUID CHROMATOGRAPHY, CODEINE (Medical Device)\tTubulostromal Adenocarcinoma (Neoplastic Process)\tCannabinoid Receptors (G-Protein-Coupled Receptors)\tradiation equivalent man - dose equivalent (Unit of radiation dose)\tCopper Cu 64-DOTA-Anti-HER3 Monoclonal Antibody U3-1287 (Radioimmunoconjugates)", + "output": "Cannabinoid Receptors (G-Protein-Coupled Receptors)" + }, + { + "input": "Definition: MIR98 gene described as human MIR98 wild-type allele is located in the vicinity of Xp11.22 and is 118 bases in length. This allele, which encodes MIR98 pre-miRNA, plays a role in the regulation of gene expression. Alteration in the expression of this gene is associated with development of head and neck squamous cell carcinomas.\nConcepts: MIR98 wt Allele (Gene or Genome)\tIntraspinal Route of Drug Administration (Parenteral Route of Drug Administration)\tDisease Steps Clinical Classification Test Code (CDISC Clinical Classification Terminology)\tdynamin 1-like protein, human (Enzyme)\tIVD Panels, Human Genetics, Blood Disorder, Bleeding, Platelet-Type, Del/Dup (IVD Panels, Human Genetics, Blood Disorder, Bleeding, Platelet-Type)", + "output": "MIR98 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Finding described as a disorder characterized by an inflammation of the nasal mucous membranes caused by an IgE-mediated response to external allergens. The inflammation may also involve the mucous membranes of the sinuses, eyes, middle ear, and pharynx. Symptoms include sneezing, nasal congestion, rhinorrhea and itching.\nConcepts: Cigarette Smoke Exposure (Finding)\tERa36 Modulator Icaritin (Biologically Active Substance)\tAllergic rhinitis (Finding)\tPedunculus lentiformis (Body Part, Organ, or Organ Component)\ttyrosine anabolism from chorismate via L-phenylalanine (Molecular Function)", + "output": "Allergic rhinitis (Finding)" + }, + { + "input": "Definition: Diagnostic, Therapeutic, and Research Equipment described as completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.\nConcepts: Tables, Examination/Treatment, Adjustable, Proctologic (Tables, Examination/Treatment, Adjustable)\tDehydrocholesterol (Cholestadienols)\tPharmaceutical Dosage Form (Specialty Uses of Chemicals)\tFish Melanoma (Neoplastic Process)\tWNT7A Gene (Gene or Genome)", + "output": "Pharmaceutical Dosage Form (Specialty Uses of Chemicals)" + }, + { + "input": "Definition: Receptor Serine/Threonine Kinase Gene described as this gene plays a role in cellular proliferation and mitogenic responses.\nConcepts: Top-Up Model Irradiation (Therapeutic or Preventive Procedure)\t7q11.2 (Cell Component)\t(S)-nandinine synthase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with NAD(P)H as one donor, and the other dehydrogenated)\ttransforming growth factor beta receptor 2 (Gene Mutation)\toverweight (High body weight)", + "output": "transforming growth factor beta receptor 2 (Gene Mutation)" + }, + { + "input": "Definition: Eye described as reduced anteroposterior thickness of the retina. This phenotype can be appreciated by retinal optical coherence tomography (OCT).\nConcepts: C2-PI3K Gene Amplification (Gene Amplification Abnormality)\tRetinal thinning (Abnormal retinal morphology)\tImplantable Paracentesis Aspirators (Active Implantable Devices)\temitefur (Organic Chemical)\tBaths, Water, Laboratory (Baths, Water)", + "output": "Retinal thinning (Abnormal retinal morphology)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of blood vessel branching.\nConcepts: PR Interval, Aggregate (ECG Measurement)\trennin (Hydrolase)\tpositive regulation blood vessel branching (positive regulation of morphogenesis of an epithelium)\tIncreased collagen crosslinked N-telopeptide [Moles/volume] in 24 hour urine (Abnormality of urine homeostasis)\tNeoplasm of Extragonadal Germ Cell (Neoplastic Process)", + "output": "positive regulation blood vessel branching (positive regulation of morphogenesis of an epithelium)" + }, + { + "input": "Definition: Signaling Protein described as astrocytic phosphoprotein PEA-15 (130 aa, ~15 kDa) is encoded by the human PEA15 gene. This protein may play a role in the regulation of sugar transport, protein localization and signal transduction.\nConcepts: down-regulation of Frizzled-LRP5/6 complex assembly (regulation of Wnt-Frizzled-LRP5/6 complex assembly)\tYoctogram (Unit of mass)\tAstrocytic Phosphoprotein PEA-15 (Biologically Active Substance)\tpyridoxal-5-dehydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)\tamine oxidase activity (Molecular Function)", + "output": "Astrocytic Phosphoprotein PEA-15 (Biologically Active Substance)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Virus, Parainfluenza described as serology reagents intended to detect antigens that permit the identification of Parainfluenza type 1 virus, a single-stranded RNA virus of the genus Paramyxovirus, family Paramyxoviridae. This virus is an etiologic agent of parainfluenza and several upper respiratory tract infections (e.g., bronchitis, pneumonia) of varying severity.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Parainfluenza 1, Antigen (Medical Device)\tGlycoprotein Syndrome, Carbohydrate-Deficient (Disorder of glycoprotein metabolism)\tCrowning during Childbirth (Clinical sign related to pregnancy)\tCellular Transformation (Tumor Initiation)\tSwish - dosing instruction imperative (RouteByMethod)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Parainfluenza 1, Antigen (Medical Device)" + }, + { + "input": "Definition: negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway described as any process that stops, prevents, or reduces the frequency, rate or extent of the dopamine receptor, phospholipase C activating pathway.\nConcepts: ALCAT1 (Gene or Genome)\t1-01 INCISIONS (Action)\tWorst Severity Past Seven Days Hand-Foot Syndrome (Clinical or Research Assessment Question)\tdown regulation of phospholipase C-activating dopamine receptor signaling pathway (Cell Function)\tMPS 2 (Genetic Diseases, X-Linked)", + "output": "down regulation of phospholipase C-activating dopamine receptor signaling pathway (Cell Function)" + }, + { + "input": "Definition: something described as a noninvasive condition in which abnormal cells are found in the lining of a breast duct. The abnormal cells have not spread outside the duct to other tissues in the breast. In some cases, ductal carcinoma in situ may become invasive cancer and spread to other tissues, although it is not known at this time how to predict which lesions will become invasive.\nConcepts: Platelet morphology abnormal (Platelet analyses)\tIntraductal adenocarcinoma, non-infiltrating (Primary malignant neoplasm of trunk)\tCHEM ORG (Science of Chemistry)\tnotum cell fate specification (cell fate specification involved in pattern specification)\tBiofeedback procedure, NOS (Psychological Comfort Promotion)", + "output": "Intraductal adenocarcinoma, non-infiltrating (Primary malignant neoplasm of trunk)" + }, + { + "input": "Definition: Diagnostic Procedure described as technique to produce 3D images to provide the ability to visualize important structures in great detail. Traditionally CT and MRI scans produced static output on film. To produce 3D images, many scans are made, and then combined by computers to produce a 3D model, which can then be manipulated by the physician. 3D ultrasounds are produced using a somewhat similar technique.\nConcepts: Transmembrane Protein 127 wt Allele (TMEM127 gene)\tThree Dimensional Imaging (Imaging Techniques)\tPancreatic Duct Stenosis (Finding)\tMaximal Debulking (Therapeutic or Preventive Procedure)\tRadiation History Negative (Finding)", + "output": "Three Dimensional Imaging (Imaging Techniques)" + }, + { + "input": "Definition: something described as a neoplasm arising from the posterior lobe of the pituitary gland.\nConcepts: PITUICYTOMA, BENIGN (Neoplasm of the posterior pituitary)\tAnti-PD1 Monoclonal Antibody (Substance with programmed cell death protein 1 inhibitor mechanism of action)\tHG-146 (Pharmacologic Substance)\tNo distension with total obstruction of flow (Finding)\tHepatocyte Nuclear Factor 4-Alpha Hyperinsulinism (Disorder of endocrine pancreas)", + "output": "PITUICYTOMA, BENIGN (Neoplasm of the posterior pituitary)" + }, + { + "input": "Definition: Psychotherapy described as a form of supportive psychotherapy in which the patient is given carefully selected material to read.\nConcepts: BIBLIOTHER (Psychotherapy)\tPharmacological Class of Investigational Therapy (Class of Trial Agent)\tSuperior pulmonary sulcus syndrome (Compression of brachial plexus)\tIVD Test Reagent/Kits, Molecular Assay, Microsatellite Instability (IVD Test Reagent/Kits, Molecular Assay)\tleukocyte count (Whole Blood Cell Test)", + "output": "BIBLIOTHER (Psychotherapy)" + }, + { + "input": "Definition: Health Care Activity described as the destroying of all forms of life, especially microorganisms, by heat, chemical, or other means.\nConcepts: ISG15 ligase activity (ISG15 transferase activity)\tNeonatal focal myoclonic seizure (Neonatal electro-clinical myoclonic seizure)\tdisinfectant (Health Care Activity)\tAnimal Mammary Gland (Animal Structures)\tenvenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism (envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism)", + "output": "disinfectant (Health Care Activity)" + }, + { + "input": "Definition: Tissue described as FASCIA of the the PARASPINAL MUSCLES in the lower back to which the ABDOMINAL MUSCLES attach. Flexion of the SPINE is accomplished by the muscles of the ABDOMINAL MUSCLES.\nConcepts: trnsdntl med8xn shrt crse gr (Hypnotherapy and/or meditation)\tLower Limit of Normal (Quantitative Concept)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, FTSJ1 (Medical Device)\tCD203c Antigen (Enzyme)\tFascia, Lumbar (Structure of fascia of trunk)", + "output": "Fascia, Lumbar (Structure of fascia of trunk)" + }, + { + "input": "Definition: Bone Marrow Stem Cell with Variable Lineage Potential described as a specialized, self-renewing cell in the bone marrow that has the capacity to differentiate into a cell with a particular function.\nConcepts: Multipotent Bone Marrow Stem Cell (Bone Marrow Stem Cell with Variable Lineage Potential)\tCalcium Phosphate Crystal Measurement (Crystal Growth Measurement)\tCosmetic.stabilityDuration (Temporal Concept)\tabsorption intestinal (Organ or Tissue Function)\tHIGH-ARCHED (Finding)", + "output": "Multipotent Bone Marrow Stem Cell (Bone Marrow Stem Cell with Variable Lineage Potential)" + }, + { + "input": "Definition: glycol catabolic process described as the chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH.\nConcepts: Quadrantectomy of breast (Excision of breast tissue)\tpropanediol catabolic process (glycol catabolic process)\tsuspension (Functional Concept)\tPlanned Pharm Target Mode of Action (Mode of Action)\tGATA6 gene (Transcription factor genes)", + "output": "propanediol catabolic process (glycol catabolic process)" + }, + { + "input": "Definition: Medical Device described as a suprapubic urological catheter and accessories is a flexible tubular device that is inserted through the abdominal wall into the urinary bladder with the aid of a trocar and cannula. The device is used to pass fluids to and from the urinary tract. This generic type of device includes the suprapubic catheter and tube, Malecot catheter, catheter punch instrument, suprapubic drainage tube, and the suprapubic cannula and trocar.\nConcepts: Catheters, Malecot (Medical Device)\tHigh Risk (Leukemia Finding)\tpositive regulation of filamentous growth (positive regulation of growth)\tFluvoxaMINE Maleate (Organic Chemical)\tCounseling;genetic (Disease counselling)", + "output": "Catheters, Malecot (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as human DRG2 wild-type allele is located in the vicinity of 17p11.2 and is approximately 20 kb in length. This allele, which encodes developmentally-regulated GTP-binding protein 2, plays a role in the regulation of cell growth and differentiation. Deletion of the region that the gene is located in is associated with Smith-Magenis syndrome.\nConcepts: Antiandrogen Treatment (endocrine-modulating drug therapy)\tchalcone synthase activity (Molecular Function)\tEmergency Power Systems (Power Systems, Electrical)\tCaps, Ophthalmic, Quarter Globe (Orbital implants)\tDevelopmentally Regulated GTP Binding Protein 2 wt Allele (Gene or Genome)", + "output": "Developmentally Regulated GTP Binding Protein 2 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Occupation or Discipline described as a class of professional or vocational positions of employment that involve business or financial operations.\nConcepts: Vaginal disorder (Disorder of pelvis)\tLegal Confession (Legal Processes)\tAB/Tubingen (Fish)\tProstaglandin F1 Alpha Measurement (Prostaglandin measurement)\tBusiness and Financial Operations Occupations (Miscellaneous Occupation)", + "output": "Business and Financial Operations Occupations (Miscellaneous Occupation)" + }, + { + "input": "Definition: protein structure function described as catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.\nConcepts: CRQ0218 (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\tSplenium of the Corpus Callosum (Body Part, Organ, or Organ Component)\tcatalytic activity (molecular function)\tMicromole per Liter per Milligram per Meter Squared (Measurement Unit Description)\tConcentration measurement (Characteristics)", + "output": "catalytic activity (molecular function)" + }, + { + "input": "Definition: Gene or Genome described as human MAPK9 wild-type allele is located within 5q35 and is approximately 45 kb in length. This allele, which encodes mitogen-activated protein kinase 9 protein, is involved in the activation of nuclear transcription factors in response to environmental stress and pro-inflammatory cytokines, stabilization of the p53 tumor suppressor protein and differentiation of T-helper cells.\nConcepts: intravenous needle (NEEDLES,INJECTION)\tQ-LES-Q-SF - Economic Status (Q-LES-Q-SF Questionnaire Question)\tJNK2 (Gene or Genome)\tPseudoepiphysis of the 1st metacarpal (Anatomical Abnormality)\tFistulous tract (Lungs and Breathing)", + "output": "JNK2 (Gene or Genome)" + }, + { + "input": "Definition: Chromosomal translocation described as a cytogenetic abnormality that refers to any translocation involving Xp11.2 on the short arm of the X chromosome.\nConcepts: Malassezia furfur; infection (Skin and subcutaneous tissue fungal infections)\tAnticardiolipin IgG Antibody (Amino Acid, Peptide, or Protein)\tBRCC36 (Gene or Genome)\tt(X;V)(p11.2;v) (Cell or Molecular Dysfunction)\tFD & C Yellow No. 5 (Allergen.miscellaneous)", + "output": "t(X;V)(p11.2;v) (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Quantitative Concept described as a metric unit of length equal to one quadrillionth of a meter (10E-15 meter).\nConcepts: Risk for bleeding (Physical injury)\tPediatric Nurse Specialist (Professional or Occupational Group)\tExercise promotion: stretching (Manipulation procedure)\tFermi (Quantitative Concept)\tindoleacetic acid breakdown (Molecular Function)", + "output": "Fermi (Quantitative Concept)" + }, + { + "input": "Definition: Development described as a clinical finding in which there is a failure to achieve expected mental or physical milestones for age.\nConcepts: Organic delusional disorder (Organic brain syndrome)\tDevelopment delay NOS (Development)\tSOX21 protein, human (Amino Acid, Peptide, or Protein)\tGrade 4 Right Ventricular Dysfunction, CTCAE (Finding)\tVaginal pain (Finding)", + "output": "Development delay NOS (Development)" + }, + { + "input": "Definition: Pharmacologic Substance described as prohibitin (272 aa, ~30 kDa) is encoded by the human PHB gene. This protein may be involved in both aging and the regulation of DNA synthesis.\nConcepts: prohibitin (Amino Acid, Peptide, or Protein)\tfriedlander's bacillus (Bacterium)\tregenerative medicine therapy (Therapeutic procedure)\tHyperemia of conjunctiva (disorder) [Ambiguous] (Eye)\tChambers, Hyperbaric (Chamber)", + "output": "prohibitin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with ubiquinone, a quinone derivative with a tail of isoprene units.\nConcepts: Neuroendocrine Carcinoma of the Skin Clinical Primary Tumor TNM Finding v8 (Finding)\tPlanned Notification (Notifications)\tGDS - Good Spirits Most of Time (Intellectual Product)\tEDUC DISTANCE (Educational Activity)\tcoenzyme Q binding (Molecular Function)", + "output": "coenzyme Q binding (Molecular Function)" + }, + { + "input": "Definition: EWSR1/ATF1 Fusion Protein described as a fusion protein (432 aa, ~46 kDa) encoded by the EWSR1/ATF1 fusion gene. This protein is comprised of the transactivation domain of the RNA-binding protein EWS followed by the DNA-binding basic domain and leucine zipper dimerization domain of the cyclic AMP-dependent transcription factor ATF-1 protein.\nConcepts: EWSR1-ATF1 Fusion Protein Type 2 (EWSR1/ATF1 Fusion Protein)\tLDH Isoenzyme 3/LDH (Laboratory Procedure)\tLifts, Wheelchair, Motor Vehicle (Medical Device)\tDecreased lipoprotein lipase level (Finding)\tSantorini's caruncle (Descending part of duodenum)", + "output": "EWSR1-ATF1 Fusion Protein Type 2 (EWSR1/ATF1 Fusion Protein)" + }, + { + "input": "Definition: Biologically Active Substance described as ankyrin repeat domain-containing protein 24 (1146 aa, ~124 kDa) is encoded by the human ANKRD24 gene. This protein plays a role in protein-protein interactions.\nConcepts: Ankyrin Repeat Domain-Containing Protein 24 (Binding Proteins)\tSH3-Binding Domain (Amino Acid Sequence)\t13: 32058624-32250157 (Chromosome 13 Physical Location)\tMammectomies (Simple mastectomy)\tPerformedStudyAdministrativeActivity (Performed Clinical Study Activity)", + "output": "Ankyrin Repeat Domain-Containing Protein 24 (Binding Proteins)" + }, + { + "input": "Definition: Organic Chemical described as the diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C102865\" active clinical trials using this agent.\nConcepts: Inward turned middle finger (Anatomical Abnormality)\tDiammonium Glycyrrhizinate (Organic Chemical)\tmyoblast fate specification involved in skeletal muscle regeneration (myoblast fate specification)\tSubglottic Cancer pT4 TNM Finding v8 (Subglottic Cancer Pathologic Primary Tumor TNM Finding v8)\tNeoplasia of the penis (Perineal lump)", + "output": "Diammonium Glycyrrhizinate (Organic Chemical)" + }, + { + "input": "Definition: Autoimmune endocrine disease described as disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol.\nConcepts: Choriogonadotropin, Intact (Choriogonadotropin measurement)\tpositive regulation cytokinesis, site selection (regulation of cytokinesis, site selection)\tcardiac progenitor cell midline fusion (homotypic cell-cell adhesion)\tPrimary adrenocortical insufficiency (Primary Adrenal Insufficiency)\tIVD Test Reagent/Kits, Immunoassay, Fertility Hormone, Luteinizing Hormone (IVD Test Reagent/Kits, Immunoassay, Fertility Hormone)", + "output": "Primary adrenocortical insufficiency (Primary Adrenal Insufficiency)" + }, + { + "input": "Definition: something described as uterine corpus leiomyosarcoma or endometrial stromal sarcoma with tumor infiltrating abdominal tissues at one site.\nConcepts: Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma FIGO Stage IIIA (Finding)\tSPI1 Oncoprotein (Oncogene Proteins)\trenin release into blood stream (Cell Function)\tHypoplastic areola (Abnormal areolar morphology)\tStage III Oropharyngeal Carcinoma (Neoplastic Process)", + "output": "Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma FIGO Stage IIIA (Finding)" + }, + { + "input": "Definition: something described as double-bladder cuffs intended for a single-use (i.e., disposable), including two inflatable bladders and a standard (typically cylindrical) shape that are designed to exert a pressure on the circumference of an extremity by means of a compressed gas delivered by a pneumatic tourniquet. These devices usually include two small bladders within the cuff that are inflated through tubes (e.g., hoses) that run from the bladder connectors to the source of compressed air located in the control unit of the tourniquet. The cuff is fastened to the extremity using contact mechanisms (e.g., clips) and frequently secured with an external ribbon. Disposable double-bladder standard cuffs are usually supplied sterile in individual pouches for only one use and are not intended for sterilization processes at the healthcare facility. They are usually made of one integral unit in which components (e.g., bladders) cannot be replaced. Disposable standard double-bladder cuffs intended for use in specific extremity areas (e.g., arm, thigh, wrist, ankle) are available. Dedicated disposable non-standard cuffs with a smaller diameter distally than proximally when wrapped (i.e., contoured cuffs) are also available.\nConcepts: Dacryocystocoele (Eye)\t1-(2-(Ethylsulfonyl)ethyl)-2-methyl-5-nitroimidazole (Nitroimidazole derivatives, antiprotozoal agents against amoebiasis and other protozoal diseases)\tAbnormality of the humeral diaphysis (Abnormal humerus morphology)\tdrug kinetics (Pharmacology and Toxicology)\tCuffs, Pneumatic Tourniquet, Double Bladder, Standard, Disposable (Cuffs, Pneumatic Tourniquet, Double Bladder, Standard)", + "output": "Cuffs, Pneumatic Tourniquet, Double Bladder, Standard, Disposable (Cuffs, Pneumatic Tourniquet, Double Bladder, Standard)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of cyclophosphamide, hydroxydaunorubicin hydrochloride (doxorubicin hydrochloride), vincristine and prednisone used to treat both indolent and aggressive forms of non-Hodgkin lymphoma.\nConcepts: VACP (Regimen Used to Treat Non-Hodgkin Lymphoma)\tRefractory Monomorphic Post-Transplant Lymphoproliferative Disorder (Neoplastic Process)\thigh density lipoprotein particle mediated signal transduction (lipoprotein particle mediated signaling)\tretinopathy of prematurity stage 1 (Retinopathy of Prematurity Finding)\tOppositional Behavior (Mental and Behavioral Signs and Symptoms)", + "output": "VACP (Regimen Used to Treat Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Organism Function described as a reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny.\nConcepts: EML4-ALK Gene Rearrangement (Cytoskeletal Gene)\tCXCR4 chemokine receptor binding (Molecular Function)\tSexual Reproduction (multi-organism reproductive process)\tMetabolic Disorder Gene Panel Reagents (IVD Panels, Human Genetics)\tcellular response to streptomycin (Cell Function)", + "output": "Sexual Reproduction (multi-organism reproductive process)" + }, + { + "input": "Definition: something described as a dataset containing supplemental information, specifically non-standard variables, to parent records in the pharmacogenomics/genetics findings domain.\nConcepts: Hypoganglionosis (Disease or Syndrome)\tPharmacogenomics/Genetics Findings Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)\tnylidrin (N [Preparations])\tIDSR1-Feeling Anxious or Tense (IDS-SR Questionnaire Question)\tAS03-adjuvanted H1N1 pandemic influenza vaccine (Vaccines, Inactivated)", + "output": "Pharmacogenomics/Genetics Findings Supplemental Qualifiers Dataset (Supplemental Qualifiers Tabulation Dataset)" + }, + { + "input": "Definition: something described as an indication as to whether an artery is patent (free of TLR or restenosis) following intervention.\nConcepts: Ophthalmological disorder (Medical Dictionary for Regulatory Activities Terminology)\tAmerican Native Continental Ancestry Group (Continental Population Groups)\tVSLPIND (Finding)\twidened (Physical shape)\tEDC (Conceptual Entity)", + "output": "VSLPIND (Finding)" + }, + { + "input": "Definition: Electromechanical Devices described as equipment designed for packaging medications in the amount needed for a single dose for an individual patient, either in separate containers or in multiple containers with separate compartments for each single dose. These equipment usually consist of a small, light way packaging unit with limited packaging capability; most unit-dose packing systems include printing capabilities for labeling the packaged drugs. Unit-dose packaging systems are used in hospitals, nurseries, and/or other long-term health care centers.\nConcepts: Sporadic Thyroid Gland Medullary Carcinoma (Medullary carcinoma of thyroid)\tMuch better (Improvement of status)\tD53 (TPD52L1 gene)\tMalignant melanoma of conjunctiva (Malignant melanoma of mucous membrane)\tUnit-Dose Packaging Systems (Medical Device)", + "output": "Unit-Dose Packaging Systems (Medical Device)" + }, + { + "input": "Definition: Biomedical or Dental Material described as an injection, which either consists of or forms liposomes (a lipid bilayer vesicle usually composed of phospholipids which is used to encapsulate an active drug substance).\nConcepts: levocetirizine dihydrochloride (levocetirizine)\t(ml/min)/(mg/m2/d) (Quantitative Concept)\tMONITOR, LUNG WATER MEASUREMENT (Medical Device)\tLiposomal Inj (Biomedical or Dental Material)\tHypericum perforatum / St. John's wort essence (Flower Essences)", + "output": "Liposomal Inj (Biomedical or Dental Material)" + }, + { + "input": "Definition: Diagnostic or Prognostic Factor described as a collection of molecular biomarkers that are associated with the medical conclusion, condition, or process.\nConcepts: MolecularBiomarkerGroup (Diagnostic or Prognostic Factor)\tCaulobacter sp. (Caulobacterales)\tStudy Legal Sponsor (Sponsor)\tRegional segment of venous tree (Subdivision of vein)\t13: 109236915-109204187 (Chromosome 13 Physical Location)", + "output": "MolecularBiomarkerGroup (Diagnostic or Prognostic Factor)" + }, + { + "input": "Definition: Cell Function described as a process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MEFV (Medical Device)\tMelanoma of the Skin by AJCC v8 Stage (Neoplastic Process)\tX-linked mental retardation 26 (Disease or Syndrome)\tBH4 Domain (Amino Acid Sequence)\tmodulation by host of viral process (modulation by host of symbiont process)", + "output": "modulation by host of viral process (modulation by host of symbiont process)" + }, + { + "input": "Definition: Measurement of substance described as a measurement of the vitronectin in a biological specimen.\nConcepts: VTN (Chemical procedure)\tpatau syndrome (Congenital eye disorders NEC)\tSARCOIDOSIS, EARLY-ONSET (Disease or Syndrome)\tOptic Nerve Astrocytoma (Neoplastic Process)\tlysosome organization and biogenesis (lytic vacuole organization)", + "output": "VTN (Chemical procedure)" + }, + { + "input": "Definition: something described as oil derived from the seeds of SUNFLOWER plant, Helianthus.\nConcepts: Esophageal pH Recordings (Gastrointestinal investigation)\ttumor necrosis factor binding (cytokine binding)\tProduct containing sunflowerseed oil (S [Preparations])\tGamma-haemolytic streptococcus (Non-Beta-hemolytic Streptococcus)\tintrinsic to periplasmic side of plasma membrane (Cell Component)", + "output": "Product containing sunflowerseed oil (S [Preparations])" + }, + { + "input": "Definition: Drug Administration Routes described as the administration of a drug within the synovial cavity of a joint.\nConcepts: Wound Aspirators (Aspirator)\tProduct containing panobinostat (Hydroxamic Acids)\tZygapophyseal joint (Set of vertebral synovial joints)\tIntrasynovial use (Musculoskeletal route)\tFoam Sheets, Dermal Wound, Silicone Gel (Medical Device)", + "output": "Intrasynovial use (Musculoskeletal route)" + }, + { + "input": "Definition: Biologically Active Substance described as PC4 and SFRS1-interacting protein isoform 1 (530 aa, ~60 kDa) is encoded by the human PSIP1 gene. This protein plays a role in transcriptional regulation, neurogenesis and HIV infection.\nConcepts: polyacyltrehalose synthesis (polyacyltrehalose metabolic process)\tbedsonia (unclassified Chlamydiae)\tDFS 70 (Amino Acid, Peptide, or Protein)\tAuditory Areas, Temporal (sensory cortex)\tMaintaining assistive devices (Caring for household objects)", + "output": "DFS 70 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Manufactured Object described as an object used in scientific research that is not consumed.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Haemophilus influenzae B, IgG Antibody (Medical Device)\tregulation of dolichol biosynthetic process (Molecular Function)\tiron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide (peptidyl-cysteine modification)\tScientific Equipment (Manufactured Object)\ttyphoid vaccines (Bacterial Vaccines)", + "output": "Scientific Equipment (Manufactured Object)" + }, + { + "input": "Definition: Action described as an indication or description that an activity has occurred.\nConcepts: Does Not Apply to My Job (Clinical or Research Assessment Answer)\tACNOTH (Action)\tStage III Lip and Oral Cavity Cancer AJCC v7 (Neoplastic Process)\tbiophysics (Physics)\tSerratia odorifera biogroup 1 (Serratia odorifera)", + "output": "ACNOTH (Action)" + }, + { + "input": "Definition: Neoplastic Process described as a rare, circumscribed or encapsulated tumor arising from the follicular cells of the thyroid gland. It is characterized by a trabecular growth pattern and hyalinized stroma formation. The vast majority of cases have a benign clinical course.\nConcepts: Root amputation-per root (Oral Surgical Procedures)\tHyperaminoaciduria (Presence of amino acid - finding)\tParaganglioma-like Adenoma (Thyroid Neoplasm)\tGrade 3 Fever Neonatal (Finding)\tGyrus, Medial Frontal (Frontal lobe gyrus)", + "output": "Paraganglioma-like Adenoma (Thyroid Neoplasm)" + }, + { + "input": "Definition: Peritoneal Diseases described as a non-neoplastic disorder that affects the peritoneum. Representative examples include peritonitis and panniculitis.\nConcepts: Radiographic densitometer (Radiological quality assurance device)\tng/L (Unit of Mass Density)\t786-0 (Experimental Model of Disease)\tSpectrometer (Gauge or Meter Device)\tNon-Neoplastic Peritoneal Disorder (Peritoneal Diseases)", + "output": "Non-Neoplastic Peritoneal Disorder (Peritoneal Diseases)" + }, + { + "input": "Definition: Clarify described as answer supplied by the investigator in response to a query. NOTE: The investigator may supply a new data point value to replace the initial value or a confirmation of the queried data point.\nConcepts: Disease, Connective Tissue (Disorder of soft tissue)\tHemoglobin Bart's Hydrops (Disease or Syndrome)\tpolycystic kidney (Cystic kidney)\tOMACICLOVIR (Organic Chemical)\tdata clarification (Clarify)", + "output": "data clarification (Clarify)" + }, + { + "input": "Definition: Temporal Concept described as prior to ingestion of food.\nConcepts: food before (ante cibus)\tElbow joint-range of movement (Finding)\tInhibitors, Topoisomerase II (Antineoplastic Agents)\tRemoval of lung (Lung & Pleura: Excision)\tPedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report - Take Long Time to Eat (PedsQL Neuromuscular Module Acute Version 3.0 Young Adult Report Questionnaire Question)", + "output": "food before (ante cibus)" + }, + { + "input": "Definition: something described as environmental monitors designed to display the concentration of nitrogen oxide and/or nitrogen dioxide. These monitors typically include appropriate sensors (e.g., electrochemical), a control unit, and a display; they may also include alarms activated at several prefixed concentrations, recording capabilities, and/or a transmitter for remote central monitoring. Nitrogen oxide/dioxide monitors are typically used to detect the presence of NO and NO2 in rooms wherever NO is used, improving the safety of healthcare personnel.\nConcepts: endocytic import into cell (Cell Physiological Processes)\tQIDSR1-General Interest (Intellectual Product)\tNitrogen Oxide/Dioxide Monitors (Monitors, Environmental)\tNull Cell Pituitary Gland Adenoma, Oncocytic Variant (Null Cell Pituitary Gland Adenoma)\tCyclooxygenase-2 inhibitor-containing product (Cyclooxygenase Inhibitor [EPC])", + "output": "Nitrogen Oxide/Dioxide Monitors (Monitors, Environmental)" + }, + { + "input": "Definition: Mutant Chimeric Proteins described as the GENETIC TRANSLATION products of the fusion between an ONCOGENE and another gene. The latter may be of viral or cellular origin.\nConcepts: I felt worthless (Clinical or Research Assessment Question)\tProteins, Oncogene Fusion (Oncogene Proteins)\tvalid (Clinical or Research Assessment Answer)\tAPCH1TC (CDISC Clinical Classification Terminology)\tWill, Psychiatric (Intellectual Product)", + "output": "Proteins, Oncogene Fusion (Oncogene Proteins)" + }, + { + "input": "Definition: Diagnostic Procedure described as technique that maintains a constant blood glucose level by perfusion or infusion with glucose or insulin; used in metabolic rate studies.\nConcepts: Foot Care (dermatology services, treatments, and remedies)\tHour Times Microgram Per Milliliter Per Milligram Per Gram (Quantitative Concept)\tmol/l/(kg/m2) (Unit of concentration)\tGlucose Clamp Technics (Blood glucose measurement)\tMed Mon Plan (Planned)", + "output": "Glucose Clamp Technics (Blood glucose measurement)" + }, + { + "input": "Definition: regulation of organic acid transport described as any process that modulates the frequency, rate or extent of fatty acid transport.\nConcepts: Saws, Postmortem, Manual (Medical Device)\tSSC (Calculation)\tIsopropanol metabolic process (secondary alcohol metabolic process)\tregulation of fatty acid transport (Molecular Function)\tAxial skeleton (Skeletal system)", + "output": "regulation of fatty acid transport (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as human EXOC7 wild-type allele is located in the vicinity of 17q25.3 and is approximately 41 kb in length. This allele, which encodes exocyst complex component 7 protein, plays a role in the mediation of exocytosis.\nConcepts: Gardner's Fibroma (fibroma)\tpligomeric procyanidolic complex (Antioxidants)\tWhite Blood Cell Decreased, CTCAE (Finding)\tAQ01-Worry About Chest Trouble (Intellectual Product)\tYJL085W (Gene or Genome)", + "output": "YJL085W (Gene or Genome)" + }, + { + "input": "Definition: Disorder of hematopoietic morphology described as a heterogeneous group of disorders with the common feature of prolonged eosinophilia of unknown cause and associated organ system dysfunction, including the heart, central nervous system, kidneys, lungs, gastrointestinal tract, and skin. There is a massive increase in the number of EOSINOPHILS in the blood, mimicking leukemia, and extensive eosinophilic infiltration of the various organs.\nConcepts: RNA methylation (nucleic acid methylation)\tHypereosinophilic syndrome [HES] (Primary malignant neoplasm)\tSchedules (Document type)\tflavonoid phytoalexin formation (flavonoid biosynthetic process)\tAston Patterning(TM) each 15 minutes (Bodywork)", + "output": "Hypereosinophilic syndrome [HES] (Primary malignant neoplasm)" + }, + { + "input": "Definition: something described as teaching a teenage parent and/or parents skills to understand and promote the physical, psychological and social growth and/or development of his or her child or children. Service is billed in 15-minute increments.\nConcepts: lateral root development (Organism Function)\tBioassay, In Vivo (Laboratory Procedure)\tTeen-parenting education individual each 15 minutes (Therapeutic or Preventive Procedure)\tADCRGW10 (ADAS-Cog CDISC Version Questionnaire Question)\tMo5 (Structure of tegmental portion of pons)", + "output": "Teen-parenting education individual each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: biology described as the study of parasites and PARASITIC DISEASES.\nConcepts: MSQL1-Get Sick Easier Than Other People (Intellectual Product)\tFRABP (Gene or Genome)\thESBGN.03 (Cell)\tparasitology (biology)\tCinobufacini (Pharmacologic Substance)", + "output": "parasitology (biology)" + }, + { + "input": "Definition: Clostridium species g-p described as any bacterial organism that can be assigned to the species Clostridium limosum.\nConcepts: needs help, but can do about half unaided (Clinical or Research Assessment Answer)\tCystic Ducts (Body Part, Organ, or Organ Component)\tEpoch.typeCode (Intellectual Product)\tClostridium limosum Andre 1948 (Clostridium species g-p)\tMRS0101 (Intellectual Product)", + "output": "Clostridium limosum Andre 1948 (Clostridium species g-p)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 0 on a fatigue scale that ranges from 0: Does Not Interfere to 10: Completely Interferes.\nConcepts: Stage IVA Uterine Corpus Leiomyosarcoma AJCC v8 (Neoplastic Process)\tcilial inversin compartment (Cell Component)\tFatigue Interference Score 0 (Intellectual Product)\tTrephines, Dental, Endodontic File/Silver Point Recovery (Medical Device)\tReport Receiver Receipt Date (Temporal Concept)", + "output": "Fatigue Interference Score 0 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying whether a device is reconditioned. EXAMPLE(S): initial use of device, reuse, unknown OTHER NAME(S): NOTE(S):\nConcepts: Electronic Fetal Monitoring: Antepartum (Childbearing Care)\tDevice Reprocessed Code (Reprocessed Code)\tpositive regulation of calcium-mediated signaling involved in cellular response to ionic osmotic stress (Molecular Function)\tSTERILIZER, ETHYLENE-OXIDE GAS (Medical Device)\tDairying (Agriculture)", + "output": "Device Reprocessed Code (Reprocessed Code)" + }, + { + "input": "Definition: something described as this gene may play a role in tumor cells and immune system interactions; however this function has not been substantiated.\nConcepts: RLS ES 07 (Reliance ES Cell Line)\tFracture, delayed union (Fracture complications)\tGLYCOPROTEIN 340 (Gene or Genome)\tZC3H7B (Ligand Binding Protein Gene)\tmedication actual dose (Quantitative Concept)", + "output": "GLYCOPROTEIN 340 (Gene or Genome)" + }, + { + "input": "Definition: examination of umbilical cord described as a complication of pregnancy and delivery in which the umbilical cord wraps around the fetal neck once or multiple times.\nConcepts: Lower thoracic kyphosis (Finding)\tFanconi syndrome acquired (Fanconi Syndrome)\tEGb 761 (Pharmacologic Substance)\tCaucasian Shepherd Dog breed (Mammal)\tnuchal umbilical cord (Pregnancy Complications)", + "output": "nuchal umbilical cord (Pregnancy Complications)" + }, + { + "input": "Definition: something described as a therapeutic vaginal douche apparatus is a device that is a bag or bottle with tubing and a nozzle. The apparatus does not include douche solutions. The apparatus is intended and labeled for use in the treatment of medical conditions except it is not for contraceptive use. After filling the therapeutic vaginal douche apparatus with a solution, the patient uses the device to direct a stream of solution into the vaginal cavity.\nConcepts: disinfection (Sterilization for infection control)\tSAR1 Homolog B (S. cerevisiae) Gene (Gene or Genome)\tregulation of focal adhesion disassembly (Cell Function)\tDOUCHE APPARATUS, VAGINAL, THERAPEUTIC (Medical Device)\tPEEVAL (Evaluator - personnel)", + "output": "DOUCHE APPARATUS, VAGINAL, THERAPEUTIC (Medical Device)" + }, + { + "input": "Definition: Treatment (General) described as program that provides spiritual, emotional, and physical care to terminally ill patients and their family\nConcepts: ScheduledActivity.statusDate (Status Date)\tDendritic Cell-Idiotype-Keyhole Limpet Hemocyanin Vaccine (Dendritic Cell Vaccine)\tmucin 6, gastric (Gene or Genome)\tSutures, Titanium (Metallic suture)\thospices (Therapeutic procedures NEC)", + "output": "hospices (Therapeutic procedures NEC)" + }, + { + "input": "Definition: Intellectual Product described as multiple Sclerosis Quality of Life-54 Instrument (MSQOL-54) Does your health limit you in these activities: Bending, kneeling, or Stooping.\nConcepts: Pancreatic Intraductal Papillary Mucinous Neoplasm with High Grade Dysplasia (Borderline Exocrine Pancreatic Neoplasm)\tMSQL1-Health Limit Bending or Kneeling (Intellectual Product)\tcprhnsv dtxifkshn U/A ea.tst (Urinalysis)\tPotassium Voltage-Gated Channel Subfamily J Member 5 wt Allele (Gene or Genome)\tTFR (Finding)", + "output": "MSQL1-Health Limit Bending or Kneeling (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as an association of DIABETES MELLITUS with Prader-Willi Syndrome.\nConcepts: C-SSRS Baseline - Ideation With Plan/Intent (Intellectual Product)\tConcentrate for oromucosal solution (Concentrated Solution Dosage Form)\tMEN2B (Thyroid Neoplasm)\tPrader-Willi syndrome AND diabetes (Multiple malformation syndrome with unusual brain and/or neuromuscular findings)\tHaemophilus haemolyticus, Beta-Lactamase Negative (Bacterium)", + "output": "Prader-Willi syndrome AND diabetes (Multiple malformation syndrome with unusual brain and/or neuromuscular findings)" + }, + { + "input": "Definition: Molecular Function described as the directed movement of inorganic cations with a valency of three into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage.\nConcepts: Power Conditioning Issue (Electrical Power Problem)\tTransplant-Related Squamous Cell Carcinoma (Transplant-Related Carcinoma)\tsulfoquinovose isomerase activity (isomerase activity)\tWPPSI-IV receptive vocabulary subtest (WAIS-IV digit span sequencing subtest)\ttrivalent inorganic cation transport (cation transport)", + "output": "trivalent inorganic cation transport (cation transport)" + }, + { + "input": "Definition: Intellectual Product described as timed 25-Foot Walk Test test name.\nConcepts: FT- T25FW TEST (CDISC Functional Test Terminology)\tinduction of phytoalexin biosynthesis (positive regulation of phytoalexin biosynthetic process)\tInterleukin 11 (Biologically Active Substance)\tatlantoaxial instability (Disorder of cervical spine)\tIRANO Okada 2015 Oncology Response Criteria (Tumor Response Criterion)", + "output": "FT- T25FW TEST (CDISC Functional Test Terminology)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA.\nConcepts: CAAX-box protein processing (Post-Translational Protein Processing)\tLIFT, PATIENT, AC-POWERED (Medical Device)\tN6-hydroxylysine O-acetyltransferase activity (Molecular Function)\tInsulin Sensitivity Measurement (Laboratory Procedure)\tmycothiol metabolic process (Sulfur Metabolism Pathway)", + "output": "N6-hydroxylysine O-acetyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: something described as catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site.\nConcepts: Classic Hodgkin Lymphoma (Hodgkin lymphoma)\tribosomal protein L22, human (Ribosomal Proteins)\tphenylethylamine metabolism (Biogenic Amine Metabolic Process)\tOriganum marjorana (Plant)\tDNA-3-methyladenine glycosylase activity (DNA-3-methylbase glycosylase activity)", + "output": "DNA-3-methyladenine glycosylase activity (DNA-3-methylbase glycosylase activity)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation.\nConcepts: FAC063-Trouble Meeting Needs of Family (Intellectual Product)\tActivated Partial Thromboplastin Time Prolonged (Investigations, CTCAE)\tnegative regulation of exocytosis (Cell Function)\tnegative regulation of cellular response to nitrogen starvation (negative regulation of cell communication)\tGRLIDENT (Lesion Identification)", + "output": "negative regulation of cellular response to nitrogen starvation (negative regulation of cell communication)" + }, + { + "input": "Definition: Peduovirus described as a species of temperate bacteriophage in the genus P2-like viruses, family MYOVIRIDAE, which infects E. coli. It consists of linear double-stranded DNA with 19-base sticky ends.\nConcepts: MACROH2A2 Gene (Gene or Genome)\tWilson's sign (SIGNS, SYMPTOMS AND MANEUVERS RELATED TO THE KNEE)\tregulation of RNA adenylating enzyme activity (regulation of transferase activity)\tPHAGE P 002 (Peduovirus)\tanaphase-promoting complex binding (protein-containing complex binding)", + "output": "PHAGE P 002 (Peduovirus)" + }, + { + "input": "Definition: something described as the directed movement of iron ions from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis.\nConcepts: BACT GENOMES (Gene or Genome)\tiron import into cell (Import into cell)\tFarming (Technology)\tAnaplastic Lymphoma Kinase Phe1245Leu (ALK NP 004295.2:p.F1245X)\tMicroRNA 221 wt Allele (MIR221 gene)", + "output": "iron import into cell (Import into cell)" + }, + { + "input": "Definition: something described as a substance being studied in the treatment of some types of leukemia and lymphoma. It is a type of purine nucleoside phosphorylase (PNP) inhibitor.\nConcepts: Forodesine Hydrochloride (Organic Chemical)\tTibial (Structure of long bone)\tCERA (Erythropoiesis-stimulating Agent [EPC])\tANTISERUM, FLUORESCENT, RUBEOLA (Indicator, Reagent, or Diagnostic Aid)\tGerman horizontal plane (Body Location or Region)", + "output": "Forodesine Hydrochloride (Organic Chemical)" + }, + { + "input": "Definition: something described as the modification of actin by addition of ubiquitin groups.\nConcepts: Rectal Perforation (Gastrointestinal Disorders, CTCAE)\tmethylgallate catabolic process (Molecular Function)\tsimmiparib (Organic Chemical)\tactin ubiquitination (Ubiquitination)\tupregulation of small GTPase mediated signal transduction (positive regulation of intracellular signal transduction)", + "output": "actin ubiquitination (Ubiquitination)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Screening - Suicidal behavior was present during the assessment period?\nConcepts: cloacogenic carcinoma of rectum (Rectal Carcinoma)\tRectosigmoid Adenocarcinoma (Adenocarcinoma of large intestine)\tCSS0920 (C-SSRS Screening Questionnaire Question)\tintraflagellar transport complex (Cell Component)\tHave Tremor (Intellectual Product)", + "output": "CSS0920 (C-SSRS Screening Questionnaire Question)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had a drink containing alcohol.\nConcepts: Potassium permanganate (Manganese and manganese compound)\t2: 105513478-105435803 (Chromosome 2 Physical Location)\tHIV-1 RNA (Microbiology procedure)\tfaeces (Human body substance)\tDid you have a drink containing alcohol (Clinical or Research Assessment Question)", + "output": "Did you have a drink containing alcohol (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.\nConcepts: tendon development (Organ or Tissue Function)\tImpregnated material (Biomedical or Dental Material)\tregulation of Rho guanyl-nucleotide exchange factor activity (Molecular Function)\tGrade 3 Retinal Vascular Disorder, CTCAE (Retinal Vascular Disorder, CTCAE)\tcervical changes (Female Reproductive System Finding)", + "output": "tendon development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as the great peninsula of southwest Asia comprising most of the present countries of the Middle East. It has been known since the first millennium B.C. In early times it was divided into Arabia Petraea, the northwest part, the only part ever conquered, becoming a Roman province; Arabia Deserta, the northern part between Syria and Mesopotamia; and Arabia Felix, the main part of the peninsula but by some geographers restricted to modern Yemen.\nConcepts: Chromosome 16 (Cell Component)\tConventional release solution for nebuliser (Pharmaceutical Solutions)\tL-lysine 6-monooxygenase (NADPH) activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen)\tArabian peninsula (Geographic Area)\tMedigoxin (digoxin)", + "output": "Arabian peninsula (Geographic Area)" + }, + { + "input": "Definition: Medical Device described as a creatinine test system is a device intended to measure creatinine levels in plasma and urine. Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes.\nConcepts: ELECTRODE, ION BASED, ENZYMATIC, CREATININE (Medical Device)\tTargeted DNA Modification (Mutation Abnormality)\tLasers, Dye, Dermatologic (Lasers, Dye)\tPapillary Epidermoid Carcinoma (Squamous Cell Neoplasms)\tType C (Classification)", + "output": "ELECTRODE, ION BASED, ENZYMATIC, CREATININE (Medical Device)" + }, + { + "input": "Definition: Health Care Related Organization described as (1) An EPO is a form of PPO, in which patients must visit a caregiver that is specified on its panel of providers (is a participating provider). If a visit to an outside(not participating) provider is made the EPO offers very limited or no coverage for the medical service; (2) While similar to a PPO in that an EPO allows patients to go outside the network for care, if they do so in an EPO, they are required to pay the entire cost of care. An EPO differs from an HMO in that EPO physicians do not receive capitation but instead are reimbursed only for actual services provided; (3) An organization identical to a preferred provider organization except that persons enrolled in the plan are eligible to receive benefits only when they use the services of the contracting providers. No benefits are available when non-contracting providers are used, except in certain emergency situations.\nConcepts: dihydroxyfluorene dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tManaged Care Organizations; Exclusive Provider Organization (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tfractures of the skull (Fracture of bone of head)\tColor Vision (Color vision observable)\tSF36 v1.0 Standard - Question 11d (Intellectual Product)", + "output": "Managed Care Organizations; Exclusive Provider Organization (HealthcareProviderTaxonomyHIPAA - CodeSystem)" + }, + { + "input": "Definition: Finding described as maxillary sinus cancer in which distant metastasis cannot be assessed.\nConcepts: ROMANOWSKY STAIN (Special Histology Staining Method)\tExperimental Result (Finding)\tMaxillary Sinus Cancer pMX TNM Finding v6 (Maxillary Sinus Cancer Pathologic Distant Metastasis TNM Finding v6)\tHPA (Body System)\tGastroscopes, Rigid (Medical Device)", + "output": "Maxillary Sinus Cancer pMX TNM Finding v6 (Maxillary Sinus Cancer Pathologic Distant Metastasis TNM Finding v6)" + }, + { + "input": "Definition: Medical Device described as masks designed to aid in oxygenation and ventilation of infant patients weighing up to 7 kg (15.4 lbs), and used in conjunction with pulmonary or cardiopulmonary resuscitation devices. These masks are constructed of rubber or plastic material and include a flexible rim to maintain an adequate seal around the nose and mouth during positive pressure ventilation. Resuscitator masks are connected through a hose to the resuscitator; they are intended to deliver air, oxygen, or a mixture of the two gases to the patient. Infant resuscitator masks are designed as either disposable or reuseable units.\nConcepts: T2 hypointense thalamus (Finding)\tMalignant Tumor of the Posterior Urethra (Neoplastic Process)\tMasks, Resuscitator, Infant (Masks, Resuscitator)\tTape lower extremity each service (Therapeutic or Preventive Procedure)\tneuromuscular junction of skeletal muscle fiber (cholinergic synapse)", + "output": "Masks, Resuscitator, Infant (Masks, Resuscitator)" + }, + { + "input": "Definition: Pharmacologic Substance described as an isomer of tetrahydrocannabinol (THC) that is the main and most active isomer found in the Cannabis sativa L. plant, with potential anti-emetic, analgesic and appetite stimulating activities. Upon administration, dronabinol, also called delta-9-THC, targets and binds to cannabinoid receptors (CBRs) located in the central nervous system (CNS). Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. In addition, this agent induces analgesia. Urine levels may be used as a marker to determine the exposure to certain preparations containing parts of the cannabis plant, such as marijuana.\nConcepts: delta(9)-THC (Other antiemetics in ATC)\tTovetumab (Anti-PDGFR Monoclonal Antibody)\tMyelopoietin (Recombinant Colony-Stimulating Factors)\tH Lee Moffitt Cancer Center & Research Institute (NCI-Designated Comprehensive Cancer Center)\tdehydroisoandrosterone (Androstan derivatives)", + "output": "delta(9)-THC (Other antiemetics in ATC)" + }, + { + "input": "Definition: Non-intestinal coccidial infection described as a protozoan infection that is acquired by the ingestion or maternal-to-fetal transmission of Toxoplasma gondii.\nConcepts: PedsQL Neuromuscular Module Version 3.0 Teen Report - Hard to Turn During Night (PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question)\tanti ulcer agents (Agent Affecting Digestive System or Metabolism)\tSystem, Genitourinary (Medical Subject Headings Norwegian)\tToxoplasma gondii infection (RESISTANCE MECHANISM DISORDERS)\t5'-methyladenosine nucleosidase activity (Molecular Function)", + "output": "Toxoplasma gondii infection (RESISTANCE MECHANISM DISORDERS)" + }, + { + "input": "Definition: Plant described as dou chi jiang\nConcepts: Litsea / dou chi jiang (Oriental herbs and natural substances letter L)\trF-gp100p209 (fowlpox virus vaccine)\tintegrin binding (Receptor Binding)\tfemale meiotic spindle assembly (cellular process involved in reproduction in multicellular organism)\tDefined Adverse Event Category Code (Category Code)", + "output": "Litsea / dou chi jiang (Oriental herbs and natural substances letter L)" + }, + { + "input": "Definition: Immunologic Factor described as an antigen expressed by tissues derived from mullerian epithelium (tubal, endometrial and endocervical) or celomic epithelium (mesothelial cells of the pleura, pericardium and peritoneum). Although its biochemical nature has not been clearly defined, CA125 has been described as a glycosylated, high-molecular-weight protein that may be released from damaged cells. Measurable in plasma, CA125 is a sensitive, nonspecific tumor marker for ovarian cancer; as such it is much more useful for monitoring clinical responses to the treatment of ovarian cancer than for the diagnosis of ovarian cancer. Elevated plasma CA125 may occur in association with other malignancies and non-malignant gynecologic disorders.\nConcepts: FAC06302 (Intellectual Product)\tCarbohydrate antigen 125 (Tumor Antigens)\tMultinucleated giant chondrocytes in epiphyseal cartilage (Finding)\tPEDIATRIC NURS (Biomedical Occupation or Discipline)\tIPA02-Vigorous Work Hours per Week (Intellectual Product)", + "output": "Carbohydrate antigen 125 (Tumor Antigens)" + }, + { + "input": "Definition: something described as the technique used to administer the tumor identification assessment.\nConcepts: Tumor Identifier Method (Health Care Activity)\tpositive regulation of amyloid precursor protein catabolic process (Molecular Function)\tReason for Narrative (Idea or Concept)\tDon't know/Don't remember (Finding)\tpositive regulation of alpha-beta T cell proliferation (positive regulation of T cell proliferation)", + "output": "Tumor Identifier Method (Health Care Activity)" + }, + { + "input": "Definition: Other diseases of pulmonary circulation described as a rare vascular anomaly with a direct communication between pulmonary artery and pulmonary vein without an intervening capillary bed.\nConcepts: Ganglioside GM2, NOS (FATTY ACIDS, LIPIDS AND LIPOPROTEINS)\tFISTULA, ARTERIOVENOUS, PULMONARY (Vascular pulmonary disorders NEC)\tChronic monilial nail infection (Nail abnormality)\tD-galactonate transmembrane transport (aldonate transmembrane transport)\tpositive regulation of macrophage apoptotic process (Cell Function)", + "output": "FISTULA, ARTERIOVENOUS, PULMONARY (Vascular pulmonary disorders NEC)" + }, + { + "input": "Definition: Neoplastic Process described as the reemergence of minor salivary gland adenocarcinoma after a period of remission.\nConcepts: Recurrent Minor Salivary Gland Adenocarcinoma (Recurrent Salivary Gland Cancer)\tresponse to aminoacetic acid (Organism Function)\tEicosanoic acid (Saturated fat)\tProviding commercial or prepared foods or beverages to supplement energy or nutrient intake. (Source: IDNT Reference Manual, edition 4; ISBN #978-0-88091-467-3). (Health Care Activity)\tDeficiency of hydroxymethylglutaryl-CoA lyase (Enzyme Deficiency)", + "output": "Recurrent Minor Salivary Gland Adenocarcinoma (Recurrent Salivary Gland Cancer)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reversible conversion of pyruvate or oxaloacetate to malate.\nConcepts: malate dehydrogenase activity (Molecular Function)\ttrans-Clomiphene (clomiphene)\tWall of right atrioventricular junction (Body Location or Region)\tHave Been Anxious about Possible Recurrence of Disease (Clinical or Research Assessment Question)\tparenting step (parent)", + "output": "malate dehydrogenase activity (Molecular Function)" + }, + { + "input": "Definition: Health Care Activity described as a set of pretreatment prognostic factors used to predict potential outcomes for neurooncology patients.\nConcepts: Tryptase (Laboratory Procedure)\tGrowth Hormone Producing Tumor of the Pituitary Gland (Hormone secreting pituitary neoplasms)\tAbscopal Effect After Radiotherapy (Finding)\tRecursive Partitioning Assessment (Cancer Intervention)\tProtein Structures, Secondary (Protein Conformation)", + "output": "Recursive Partitioning Assessment (Cancer Intervention)" + }, + { + "input": "Definition: directional locomotion described as posterior movement of an organism, e.g. following the direction of the tail of an animal.\nConcepts: backward locomotion (directional locomotion)\tMesencephalon (Brain part)\tHave Autoimmune or Inflammatory Condition (Intellectual Product)\ttachykinin receptor activity (Molecular Function)\tperspiring (Hypoglycemia Severity)", + "output": "backward locomotion (directional locomotion)" + }, + { + "input": "Definition: something described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex.\nConcepts: ATP phosphohydrolase (mitochondrial protein-importing) activity (ATPase-coupled protein transmembrane transporter activity)\tAUC Infinity Pred Norm by BMI (Area Under Curve)\tGranulosa cell of ovary (Ovarian Follicle)\tventral anterior cingulate area 24 (Brodmann area)\tHepatitis E Virus IgG Antibody Measurement (Hepatitis E Virus Antibody Measurement)", + "output": "ATP phosphohydrolase (mitochondrial protein-importing) activity (ATPase-coupled protein transmembrane transporter activity)" + }, + { + "input": "Definition: something described as a question associated with the FACT-L Version 4 questionnaire.\nConcepts: Malignant Tumor of Extragonadal Germ Cell (Malignant germ cell neoplasm)\tFACT-L Version 4 Questionnaire Question (Clinical or Research Assessment Question)\tSIQ0119 (SIQ Questionnaire Question)\tRegulator of G-Protein Signaling 22 (Amino Acid, Peptide, or Protein)\tadrenomedullin (Peptide Hormone Gene)", + "output": "FACT-L Version 4 Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intelligence Scale described as the fourth version of the Wechsler Adult Intelligence Scale that was published in 2008. It is a test designed to measure intelligence in individuals ranging in age from 16 to 90 years.\nConcepts: Brachial Vein (Body Part, Organ, or Organ Component)\tWechsler Adult Intelligence Scale IV (Intellectual Product)\tPUL02-Right Elbow Extension ROM (Intellectual Product)\tStage IIIC Vulvar Carcinoma AJCC v8 (Stage III Vulvar Cancer AJCC v8)\tExercise & Sports Psychologist (Professional or Occupational Group)", + "output": "Wechsler Adult Intelligence Scale IV (Intellectual Product)" + }, + { + "input": "Definition: Functional Concept described as methodology used to compensate an individual or organization for the good or service provided.\nConcepts: ild interstitial lung disease (Disease or Syndrome)\tresponse to cortisone stimulus (response to alcohol)\tAdnexal Carcinoma (Primary malignant neoplasm)\tPayment Method (Methods)\tDrought (Weather)", + "output": "Payment Method (Methods)" + }, + { + "input": "Definition: something described as the rel/NF-kB family of transcription factors regulates the activity of genes involved in the immune response, hematopoiesis, and inflammation. NF-kB is a complex of two proteins, p65 (rel) and p50. NF-kB is held inactive in the cytoplasm by I-kB, until signals initiated by TNF or several other factors lead to the phosphorylation and degradation of I-kB and the subsequent release of NF-kB to bind DNA and activate genes. The activation of transcription by NF-kB requires transcriptional coactivators such as p300 and CBP to interact with the rest of the transcriptional apparatus. These coactivators posses enzyme activity, acting to catalyze the posttranslational acetylation of proteins on lysine groups. Acetylation of histones has been known for some time to occur in transcriptionally active chromatin regions. Histone deacetylase (HDAC) enzymes reverse the acetylation of histones. As with other signals, there an off-switch as well as an on-switch for NF-kB activation. The signal to terminate gene activation by NF-kB involves regulation of NF-kB acetylation. P300 and CBP recruited by NF-kB to the transcriptional complex acetylate RelA. Acetylated NF-kB proteins do not interact with I-kB and so continue stimulating transcription. To turn off NF-kB dependent transcription, the histone deacetylase HDAC3 binds to and deacetylates RelA, which then interacts strongly with I-kB once again and is inactivated. The reformed complex of NF-kB and I-kB is exported from the nucleus to the cytoplasm where it replenishes the pool of inactive NF-kB awaiting the next activation signal. The activity of other proteins may also be regulated by acetylation in a similar manner.\nConcepts: Recurrent cutaneous fungal infections (Recurrent fungal infections)\tRELA Pathway (Molecular Function)\tacquisition of nutrients from other organism during symbiotic interaction (Cell Function)\tAlpha-Methylacyl Coenzyme A Racemase (Protein or Enzyme Type Measurement)\tPROTSFR (Protein S measurement)", + "output": "RELA Pathway (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as multianalyte point-of-care analyzers designed to determine the concentration of analytes in the blood and urine that is appropriate for diabetes disease management. The most frequently measured analytes are glycated hemoglobin (GHB), also known as glycohemoglobin, in whole blood, and urine creatinine and albumin. The amount of GHB in blood represents the integrated values for glucose for the previous three months; the value of the albumin/creatinine ratio may be an indicator of microalbuminuria. These devices typically consist of a portable analyzer that includes a reagent cartridge to collect and assess the samples; they may use several measuring techniques, including photometry and immunoassay. Point-of-care analyzers for diabetes management are used in clinics and physician's offices to obtain criteria in assessing glucose control and/or to find early signs of possible diabetes-related nephropathy.\nConcepts: Ribonucleotide Reductase R1 Subunit (Biologically Active Substance)\tAnalyzers, Point-of-Care, Whole Blood/Urine, Multianalyte, Diabetes (Analyzers, Point-of-Care)\tAgreement Rating Score 4 (6 Point Agreement Scale)\tED206 4 (Intellectual Product)\tmtDNA metabolism (Genetic Function)", + "output": "Analyzers, Point-of-Care, Whole Blood/Urine, Multianalyte, Diabetes (Analyzers, Point-of-Care)" + }, + { + "input": "Definition: something described as cone telodendria are projections that originate from the cone pedicle and form gap junctions with other photoreceptors within the outer plexiform layer of the retina.\nConcepts: cone telodendria (telodendria)\tPatient device direct feed (Reporting)\tanterior spinothalamic tract of the medulla (Body Part, Organ, or Organ Component)\ttopoisomerase inhibitor (Substance with effector mechanism of action)\tTumor Necrosis Factor (Ligand) Superfamily, Member 13 wt Allele (Gene or Genome)", + "output": "cone telodendria (telodendria)" + }, + { + "input": "Definition: ketone catabolic process described as the chemical reactions and pathways resulting in the breakdown of chalcone, phenyl steryl ketone or its hydroxylated derivatives.\nConcepts: Mobility of bone functions (Functions of the joints and bones)\tchalcone degradation (phenylpropanoid catabolic process)\tPIK3CA E545 Mutation (PIK3CA Protein Variant)\tsaxitoxin (Organic Chemical)\tphagocytosis avoidence (modulation by symbiont of entry into host)", + "output": "chalcone degradation (phenylpropanoid catabolic process)" + }, + { + "input": "Definition: Skull groove described as skull groove, each instance of which is a groove adjacent to the foramen magnum on the inner surface of some occipital bone where some marginal sinus lodges.\nConcepts: Groove for marginal sinus (Anatomical line)\tAcute Granulocytic Leukemia Gene Deletion/Duplication Panel Reagents (Medical Device)\tUDP-N-acetylglucosamine transmembrane transporter activity (pyrimidine nucleotide-sugar transmembrane transporter activity)\tToxascariasis (Ascaridida Infections)\t4p12 (Chromosome band)", + "output": "Groove for marginal sinus (Anatomical line)" + }, + { + "input": "Definition: Antihypertensive Agents described as a pharmaceutical agent that inhibits angiotensin-converting enzyme (ACE), which catalyzes the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in a reduction in angiotensin II and angiotensin II-induced aldosterone secretion, causing vasodilation and natriuresis. It is primarily used for the reduction of proteinuria and the treatment of hypertension.\nConcepts: Emergency Immobilizers, Head/Cervical, Pediatric, Extrication Collar (Emergency Immobilizers, Head/Cervical, Pediatric)\tAngiotensin I-Converting Enzyme Inhibitor (Protease Inhibitors)\tHelianthemum canadense / frost plant / frost weed / rock rose (Organic Chemical)\tCongenital cataract with deafness and hypogonadism syndrome (Hereditary disorder of endocrine system)\tTenth intercostal compartment space (Space of intercostal compartment)", + "output": "Angiotensin I-Converting Enzyme Inhibitor (Protease Inhibitors)" + }, + { + "input": "Definition: something described as stage IIIB includes: (T3, N1, M0); (T4, N1, M0). T3: Tumor invades through the muscularis propria into subserosa or into mesoappendix. T4: Tumor penetrates visceral peritoneum including mucinous peritoneal tumor within the right lower quadrant and/or directly invades other organs or structures. N1: Metastasis in 1-3 regional lymph nodes. M0: No distant metastasis.\nConcepts: regulation of heptadecane anabolism (Molecular Function)\tecchondroma (Osteochondrodysplasias)\tStage IIIB Appendix Carcinoma (Appendix Carcinoma by AJCC v7 Stage)\treal-time position-tracking imaging (Diagnostic Procedure)\tScrotal structure (Epididymis, vas deferens, spermatic cord and scrotum)", + "output": "Stage IIIB Appendix Carcinoma (Appendix Carcinoma by AJCC v7 Stage)" + }, + { + "input": "Definition: Anatomical Abnormality described as fissure within the spinal cord of the neck.\nConcepts: Medial periolivary nuclei set (Set of nuclei of neuraxis)\tcellular response to gibberellic acid stimulus (cellular response to acid chemical)\tOuter Leaflet of the Lipid Bilayer (Cardinal cell part)\tSGRQ02-Everything Too Much Effort (Intellectual Product)\tCervicomedullary schisis (Anatomical Abnormality)", + "output": "Cervicomedullary schisis (Anatomical Abnormality)" + }, + { + "input": "Definition: Focal cognitive seizure with deja vu/jamais vu described as a focal cognitive seizure with deja vu / jamais vu characterized by impairment of awareness at some point during the seizure.\nConcepts: UDP galactose-N-acylsphingosine galactosyltransferase activity (Molecular Function)\t879 FAMILIES HYSTRICIDAE AND ERITHIZONTIDAE (Porcupines)\tSubclavian vein (Veins)\tFocal impaired awareness cognitive seizure with deja vu/jamais vu (Disease or Syndrome)\tNicotiana alata / nicotiana (Flower Essences)", + "output": "Focal impaired awareness cognitive seizure with deja vu/jamais vu (Disease or Syndrome)" + }, + { + "input": "Definition: something described as subjective Opiate Withdrawal Scale (SOWS Subjective) I feel nauseous.\nConcepts: SOWSA112 (Intellectual Product)\tpositive regulation of pro-B cell differentiation (regulation of pro-B cell differentiation)\tUracil Nucleotides (Pyrimidine Nucleotides)\tHansenulas (Pichiaceae)\talpha-synuclein (Amino Acid, Peptide, or Protein)", + "output": "SOWSA112 (Intellectual Product)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the insulinoma-associated protein 2 antibody in a biological specimen.\nConcepts: Radiographic biomechanical report one region each report (Analysis and/or documentation services with or without ICD diagnosis)\tJapanese apricot (Fruit)\tPolo-like kinase 1 inhibitor TAK-960 (Pharmacologic Substance)\tmetanephric nephron development (nephron development)\tInsulinoma-Associated Protein 2 Antibody (Laboratory Procedure)", + "output": "Insulinoma-Associated Protein 2 Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: something described as test names of questionnaire questions associated with the the version 2.0 of the work productivity and activity impairment specific health problem questionnaire (WPAI:SHP) for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: CDISC Questionnaire WPAI:SHP v2.0 Test Name Terminology (CDISC Questionnaire Terminology)\tGlobal psychosocial functions (Mental Process)\tgases (General chemical forms)\tTarry stool (Disease digestive system other)\tBIURET (COLORIMETRIC), TOTAL PROTEIN (Medical Device)", + "output": "CDISC Questionnaire WPAI:SHP v2.0 Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: cellular diagnosis, childhood Hodgkin lymphoma described as a nodular lymphocyte predominant Hodgkin lymphoma occurring in children.\nConcepts: Pediatric NLPHD (Neoplastic Process)\tprotein maturation by [2Fe-2S] cluster transfer (protein maturation by iron-sulfur cluster transfer)\tTALL-2 (Gene or Genome)\tStage 0 Merkel Cell Carcinoma (Neoplastic Process)\tAnastomosis Couplers, Gastrointestinal (Anastomosis coupler)", + "output": "Pediatric NLPHD (Neoplastic Process)" + }, + { + "input": "Definition: eicosanoid metabolism described as eicosanoid Degradation consists of conjugation, transport, and/or oxidation of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.\nConcepts: Eicosanoid Degradation (fatty acid derivative catabolic process)\tEpidermal Growth Factor Receptor Gene c.2307 2308ins9 (EGFR Exon 20 Insertion Mutation)\tSAR1B wt Allele (SAR1B gene)\thysterosonography (Ultrasonography)\tTissue saturation oximeter (Analyzer, device)", + "output": "Eicosanoid Degradation (fatty acid derivative catabolic process)" + }, + { + "input": "Definition: Regulatory Protein described as brain and acute leukemia cytoplasmic protein (180 aa, ~19 kDa) is encoded by the human BAALC gene. This protein may be involved in synapse function or hematopoiesis.\nConcepts: Interleukin 11 wt Allele (Gene or Genome)\tBrain and Acute Leukemia Cytoplasmic Protein (Regulatory Protein)\tCarbamyl Phosphate Synthase (Amino Acid, Peptide, or Protein)\tDietary Supplement Marketing Category (Structured Product Labeling Marketing Category)\tRecurrent Nodal Marginal Zone B-Cell Lymphoma (Marginal zone lymphoma recurrent)", + "output": "Brain and Acute Leukemia Cytoplasmic Protein (Regulatory Protein)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as approaches that emphasize manipulation and realignment of the body's structure in order to improve function as well as mental outlook.\nConcepts: MOLIBRESIB (Pharmacologic Substance)\tBodywork (Therapeutic or Preventive Procedure)\tTSCYC - Not Paying Attention in Own World (TSCYC Questionnaire Question)\tHave Limited Movement of Elbow (Findings-Based Question)\tStage IA2 (FIGO Stage IA)", + "output": "Bodywork (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as a sequence of characters used to link multiple records to a single finding.\nConcepts: Class II Major Histocompatibility Molecules (Membrane Glycoproteins)\tC166011 (Ribonucleic Acid Measurement)\tLink Group Identifier (Identifier)\tanti-SLITRK6 monoclonal antibody-MMAE conjugate AGS15E (Antineoplastic Antibody-Drug Conjugate)\tAdrenal Cancer pT3 TNM Finding v7 (Adrenal Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Link Group Identifier (Identifier)" + }, + { + "input": "Definition: Medical Device described as urinary tract surgical retractors designed to temporarily separate and hold back of the lips of the renal sinus, exposing and providing access to other tissues or renal structures. These retractors are usually handheld manual instruments which include a smooth concave and blunt blade at the distal end that is perpendicular to the shaft, and an integral flat handle. Renal sinus retractors are used during surgical procedures of the kidneys, including extraction of renal calculi through pyelotomy.\nConcepts: manual traction (Therapeutic or Preventive Procedure)\tINTERLEUKIN 023 SUBUNIT P19 (interleukin-23)\tnicotine gum (Nicotine-containing product in oropharyngeal dose form)\tRetractors, Surgical, Urinary Tract, Renal Sinus (Medical Device)\tNo (Finding)", + "output": "Retractors, Surgical, Urinary Tract, Renal Sinus (Medical Device)" + }, + { + "input": "Definition: something described as any structural anomaly of the bladder. []\nConcepts: DYSARTHROSIS (Voice)\tAbnormality of bladder morphology (Abnormality of the bladder)\tBartonella henselae (Bartonella)\tnegative regulation of acetylcholine biosynthesis (negative regulation of acetylcholine metabolic process)\tSexual dysfunction NOS (Symptoms and signs involving the genitourinary system)", + "output": "Abnormality of bladder morphology (Abnormality of the bladder)" + }, + { + "input": "Definition: something described as catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin.\nConcepts: anaerobic acetylene catabolic process (alkyne catabolic process)\timmunopathology (Disease)\tAcidaminococcus, NOS (Gram-negative coccus)\tVEIN, SAPHENA (Structure of superficial vein of lower extremity)\t1,4alpha-glucan-protein synthase (UDP-forming) activity (Molecular Function)", + "output": "1,4alpha-glucan-protein synthase (UDP-forming) activity (Molecular Function)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with the AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).\nConcepts: Double 1st long bones of hand (Supernumerary metacarpal bone)\tAP-2 adaptor complex binding (protein-containing complex binding)\tAbility to Take a Tub Bath (Intellectual Product)\ttubes tracheostomy (biomedical tube device)\tHistone Acetyltransferase KAT6A/Nuclear Receptor Coactivator 2 Fusion Protein (Fusion protein)", + "output": "AP-2 adaptor complex binding (protein-containing complex binding)" + }, + { + "input": "Definition: Medical Device described as used to measure oxygen and carbon dioxide.\nConcepts: osteochondrodys w/ defects grow tubular bones&spine chondrodysplasia punctata (Osteochondrodysplasias)\trespiratory gas analyzer (Medical Device)\tregulation of diacylglycerol biosynthetic process (Molecular Function)\tRAD52, Yeast Homolog of Gene (RAD52 gene)\tdown-regulation of bleb assembly (regulation of bleb assembly)", + "output": "respiratory gas analyzer (Medical Device)" + }, + { + "input": "Definition: Epstein-Barr Virus Infection Reactivation, CTCAE described as severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated\nConcepts: regulation of branching involved in lung morphogenesis (regulation of morphogenesis of an epithelium)\tCRKR (Cyclin-Dependent Kinase Gene)\tGrade 3 Epstein-Barr virus infection reactivation (Epstein-Barr Virus Infection Reactivation, CTCAE)\tDacryocystitis osteopoikilosis (Disease or Syndrome)\tSlip Ring (Ring device)", + "output": "Grade 3 Epstein-Barr virus infection reactivation (Epstein-Barr Virus Infection Reactivation, CTCAE)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 3q\nConcepts: Arylsulfatase A, human (Amino Acid, Peptide, or Protein)\tchelidonium majus/celandine (Western herbs and natural substances letter C)\t3q21-q28 (Cell Component)\tClinical Parasitology (Clinical Medicine)\tIn the past 7 days, how often did you have ejaculation problems (Clinical or Research Assessment Question)", + "output": "3q21-q28 (Cell Component)" + }, + { + "input": "Definition: Pathologic Function described as hypersensitivity in form of an adverse immune reaction against alpha-gal. []\nConcepts: Danio rerio frankei (Fish)\tConsumer Psychology (Psychology, Applied)\tCSS04-Non-Spec Suicid Thought, Describe (C-SSRS Baseline/Screening Version Questionnaire Question)\tPentamethylenetetrazole (Organic Chemical)\tAlpha-gal allergy (Hypersensitivity)", + "output": "Alpha-gal allergy (Hypersensitivity)" + }, + { + "input": "Definition: Miscellaneous substance administration described as any elsewhere undefined miscellaneous substance administration, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Deleterious FANCN Gene Mutation (Deleterious Mutation)\tHealth planning (Health Care Activity)\tGerminomatous Germ Cell Tumor (Germ cell tumor)\tundef.misc.subst admin.na (Therapeutic or Preventive Procedure)\tNeoplasm of Pineal Gland (Tumor of the Pineal Region)", + "output": "undef.misc.subst admin.na (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Severity of the disinhibition.\nConcepts: plozalizumab (Amino Acid, Peptide, or Protein)\tNPI - Disinhibition Severity (Intellectual Product)\tGTP:GDP antiporter activity (Molecular Function)\tLNSTATE (Qualitative Concept)\tOral pain (Gastrointestinal Disorders, CTCAE)", + "output": "NPI - Disinhibition Severity (Intellectual Product)" + }, + { + "input": "Definition: DRRI-2 Questionnaire Question described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I was concerned that a rocket or mortar would hit our living quarters.\nConcepts: Craniotomy (cranial surgery)\tUPD110 (UPDRS Questionnaire Question)\tDRRI1G07 (Intellectual Product)\tVaginal Carcinoma pT1 TNM Finding v8 (Finding)\tElectrical engineers (Professional or Occupational Group)", + "output": "DRRI1G07 (Intellectual Product)" + }, + { + "input": "Definition: Embryonic body cavity described as two thin canals, located on either side of the foregut and dorsal to the septum transversum, that connect the thoracic and abdominal portions of the intraembryonic coelom, which subsequently forms the pleural cavities.\nConcepts: Alkaloids, Indole (Alkaloids)\tPericardioperitoneal Canal (Embryonic respiratory structure)\tNEW SEPTAL WALL MYOCARDIAL INFARCTION (New Myocardial Infarction by ECG Finding)\tBullet-shaped outermost bone of the middle finger (Bullet-shaped distal phalanges of the hand)\tChildhood Paranasal Sinus Carcinoma (Paranasal Sinus Cancer)", + "output": "Pericardioperitoneal Canal (Embryonic respiratory structure)" + }, + { + "input": "Definition: something described as human STX7 wild-type allele is located in the vicinity of 6q23.2 and is approximately 67 kb in length. This allele, which encodes syntaxin-7 protein, is involved in the trafficking of endocytic vesicles. A fusion involving this gene and the ICAM2 gene may be associated with acute monoblastic and monocytic leukemia.\nConcepts: UHDRS 1999 Version - Behavior Assessment Obtained From (UHDRS 1999 Version Clinical Classification Question)\tGenetic toxicology (Biomedical Occupation or Discipline)\tSTX7 wt Allele (Gene or Genome)\tBODE0103 (Intellectual Product)\tkeyhole limpet hemocyanin (Immunologic Adjuvants)", + "output": "STX7 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Finding described as anal cancer with metastasis in inguinal, mesorectal, internal iliac, or external iliac nodes.\nConcepts: Hortonia Wight & Arn. (Plant)\tDecreased platelet glycoprotein VI (Finding)\tAnal Carcinoma pN1 TNM Finding v8 (Finding)\tinterneuron axon guidance (Axon Guidance)\tmodulation by virus of host ubiquitin-protein ligase activity (modulation by virus of host catalytic activity)", + "output": "Anal Carcinoma pN1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Organic Chemical described as a (-)-epicatechin with a hydroxyl group at C-5'.\nConcepts: heme protein (Metalloproteins)\t(-)-epi-gallocatechin (Organic Chemical)\tIMPLANT, FIXATION DEVICE, CONDYLAR PLATE (Medical Device)\tUHDR191 (UHDRS 1999 Version Clinical Classification Question)\tShovel-shaped maxillary central incisors (Abnormality of incisor morphology)", + "output": "(-)-epi-gallocatechin (Organic Chemical)" + }, + { + "input": "Definition: Respiratory Tract Infections described as an inflammatory process affecting the wall of the trachea.\nConcepts: C-SSRS Baseline - Number of Interrupted Suicide Attempts (C-SSRS Baseline Questionnaire Question)\ttracheitis (Inflammatory disorder of the respiratory tract)\tPhagosomes (Transport Vesicles)\tdichloroacetic acid (Pharmacologic Substance)\tFamily Sociology (Sociology)", + "output": "tracheitis (Inflammatory disorder of the respiratory tract)" + }, + { + "input": "Definition: TRIM23 gene described as human TRIM23 wild-type allele is located in the vicinity of 5q12.3 and is approximately 36 kb in length. This allele, which encodes E3 ubiquitin-protein ligase TRIM23 protein, plays a role in both protein ubiquitination and viral processes.\nConcepts: protein serine/threonine kinase inhibitor activity (protein kinase inhibitor activity)\tTRIM23 wt Allele (TRIM23 gene)\tprotein homodimerization activity (protein dimerization activity)\tCellLife(TM) Forever Joints-Connective Tissue Support multi-organ and body component each 3 ml bottle (Nutraceuticals)\tCSS04-Idea, Plan, Intent-P M (Intellectual Product)", + "output": "TRIM23 wt Allele (TRIM23 gene)" + }, + { + "input": "Definition: something described as the process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system.\nConcepts: Have Axillary Fullness or Numbness (Intellectual Product)\tResectable Extrahepatic Bile Duct Adenocarcinoma (Bile duct cancer resectable)\tprotein secretion by the type VII secretion system (Protein translocation)\tOcular Carcinoma (malignant neoplasm of eye histology)\tFunctional MRIs (Functional Imaging)", + "output": "protein secretion by the type VII secretion system (Protein translocation)" + }, + { + "input": "Definition: Classification described as the status of central nervous system leukemia at diagnosis, where there are less than 5 white blood cells per microliter on a cerebral spinal fluid cytospin preparation that is positive for blasts; or greater than 5 white blood cells per microliter on a cerebral spinal fluid cytospin preparation that is considered negative by Steinherz/Bleyer algorithm.\nConcepts: DRIED (Body Substance)\tsulfathiazole transmembrane transporter activity (sulfur compound transmembrane transporter activity)\t1,4-beta-D-xylan xylohydrolase activity (Molecular Function)\tp110alpha E545D (PIK3CA NP 006209.2:p.E545X)\tCNS 2 (Classification)", + "output": "CNS 2 (Classification)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's ability to walk 3 miles nonstop.\nConcepts: Walking 3 Miles Nonstop (Intellectual Product)\tDistal Arthrogryposis Type 1 (Congenital Abnormality)\tGATE-16 (GABARAPL2 gene)\tEMO1-Number Stimuli Portraying Surprise (Intellectual Product)\tregulation of anterior head development (Biologic Function)", + "output": "Walking 3 Miles Nonstop (Intellectual Product)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent of Toddler (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler) In the past 7 days, how much of a problem has this been for your child: My child gets sores and/or rashes.\nConcepts: Oligocone syndrome (Hereditary retinal dystrophy)\tX-linked intellectual disability Zorick type (x-linked intellectual disability)\tTeratoma of Ovary (Malignant Ovarian Germ Cell Neoplasm)\tDistal Common Bile Duct (Common bile duct structure)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Get Sores and/or Rashes (Intellectual Product)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Get Sores and/or Rashes (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the transport of proteins into the mitochondrion.\nConcepts: Investigational Product and Clinical Trial Supplies Filenote (Intellectual Product)\ttranslocase of outer mitochondrial membrane 20 homolog (Gene or Genome)\tBiopsy of adenoids (Biopsy of nasopharynx)\tWBC Clumps (Laboratory Procedure)\tPre-mRNA Processing Factor 40 Homolog B wt Allele (PRPF40B gene)", + "output": "translocase of outer mitochondrial membrane 20 homolog (Gene or Genome)" + }, + { + "input": "Definition: UPDRS Questionnaire Question described as unified Parkinson's Disease Rating Scale - Motor examination: Speech.\nConcepts: Wedging of vertebra (Vertebral column finding)\tUPDRS - Motor Examination: Speech (Intellectual Product)\tLabium Majus (Body Part, Organ, or Organ Component)\tMSC protein, human (TRANSCRIPTION FACTOR)\tChlamydozoon trachomatis (Bacterium)", + "output": "UPDRS - Motor Examination: Speech (Intellectual Product)" + }, + { + "input": "Definition: something described as denotes the inhabitants of the Democratic Republic of the Congo (formerly Zaire), a person from there, or their descendants elsewhere.\nConcepts: Missing or Inadequate Safety Measures Problem (Finding)\tThymic neuroendocrine carcinoma (carcinoma of thymus)\tAdvanced Malignant Female Reproductive System Neoplasm (Metastatic Malignant Female Reproductive System Neoplasm)\tAPI2/MALT1 Fusion Gene (Fusion Gene)\tZairean (African race)", + "output": "Zairean (African race)" + }, + { + "input": "Definition: Cervical Squamous Intraepithelial Neoplasia described as a precancerous neoplastic process that affects the cervical squamous epithelium. It is usually associated with human papillomavirus infection. It is classified as cervical squamous intraepithelial neoplasia 2 when there is nuclear atypia in both the upper and lower epithelial layers, mitotic figures are confined to the basal two-thirds of the epithelium, and maturation is present in the upper half of the epithelium. It is classified as cervical squamous intraepithelial neoplasia 3 when there is nuclear atypia and mitotic figures throughout the entire thickness of the epithelium, and maturation is absent or confined to the upper third of the epithelium.\nConcepts: TEST, ALBUMIN COBALT BINDING (Medical Device)\tHigh-Grade Cervical Squamous Intraepithelial Lesion (High Grade Cervical Intraepithelial Neoplasia)\tDecreased amplitude of sensory action potentials (Abnormal peripheral action potential amplitude)\testablishment of melanosome localization (establishment of pigment granule localization)\tInflammation of subcutaneous tissue (Inflammatory disorder)", + "output": "High-Grade Cervical Squamous Intraepithelial Lesion (High Grade Cervical Intraepithelial Neoplasia)" + }, + { + "input": "Definition: Intellectual Product described as a response indicating that a person's extremity pain is at an intermediate level: between none and modest.\nConcepts: Decreased CSF glutamine concentration (Finding)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Verapamil (Medical Device)\tNone to Modest Pain (Clinical or Research Assessment Answer)\tPKD3, FORMERLY (Cystic Kidney Diseases)\tDRRI-2 - F: Received Vaccinations (DRRI-2 Questionnaire Question)", + "output": "None to Modest Pain (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein.\nConcepts: Pediatric Central Nervous System Embryonal Carcinoma (Childhood Central Nervous System Germ Cell Tumor)\tGPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine (Molecular Function)\tGrade 3 Hemoglobin increased (Hemoglobin Increased, CTCAE)\tBiological Pesticides (Biologically Active Substance)\tRunning 110 Yards or Playing Softball or Baseball (Clinical or Research Assessment Question)", + "output": "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine (Molecular Function)" + }, + { + "input": "Definition: Ribonucleotides described as guanosine cyclic 3',5'-(hydrogen phosphate). A guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3'- and 5'-positions. It is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases.\nConcepts: Neoplasms, Treatment Related (Neoplasm by Cause)\tFAC06206 (Intellectual Product)\tEstimated intake of N-3 fatty acid in 24 hours (N-3 fatty acid intake)\tGuanosine, cyclic 3',5'-(hydrogen phosphate) (Nucleic Acid, Nucleoside, or Nucleotide)\tregulation of interleukin-25 biosynthesis (regulation of interleukin-17 biosynthetic process)", + "output": "Guanosine, cyclic 3',5'-(hydrogen phosphate) (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Definitive germ cell described as definitive germ cell of the male sex.\nConcepts: multisubunit RNA polymerase (transferase complex, transferring phosphorus-containing groups)\tTooth Eruptions, Ectopic (Tooth Diseases)\tLincosamide Antibiotic (Organic Chemical)\tHMWK (Amino Acid, Peptide, or Protein)\tcell sperm (Body part)", + "output": "cell sperm (Body part)" + }, + { + "input": "Definition: something described as AIDS-related Kaposi sarcoma in which the CD4 cell count is 150 or more cells per cubic mm.\nConcepts: TSCC0110 (Intellectual Product)\tABDOMINAL RIGIDITY (Palpation of abdomen)\tControl (General adjectival modifier)\tAIDS-Related Kaposi Sarcoma I0 (AIDS-Related Kaposi Sarcoma I (Immune System) Status)\tDiabetic Embryopathy (Fetal or neonatal effect of maternal complication of pregnancy)", + "output": "AIDS-Related Kaposi Sarcoma I0 (AIDS-Related Kaposi Sarcoma I (Immune System) Status)" + }, + { + "input": "Definition: Anti-Asthmatic Agents described as agent that causes an expansion of the lumen of a bronchus or bronchiole.\nConcepts: Resource Informatics (Informatics)\tDistress over Physical Problem with Nausea (Findings-Based Question)\tS-(2-hydroxyacyl)glutathione hydrolase activity (thiolester hydrolase activity)\tTest Reference Text List (Test Result Report)\tBronchodilator agents (Pharmacologic Substance)", + "output": "Bronchodilator agents (Pharmacologic Substance)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of Influenza A H1N1 viral load present in a sample.\nConcepts: Safety and Tolerability (Component of Study Protocol)\t123-I-MIP-1072 (Radioconjugate)\tDS-3078a (Pharmacologic Substance)\tInfluenza A H1N1 Viral Load Measurement (Laboratory Procedure)\tInstitution Not Defined (Health Care Related Organization)", + "output": "Influenza A H1N1 Viral Load Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Findings-Based Question described as a question about an individual's overall quality of life.\nConcepts: Grade 1 Urostomy Obstruction, CTCAE (Finding)\tyour overall Quality of Life (Findings-Based Question)\tD-Glucose in linear form (Organic Chemical)\tLaryngeal Cancer Clinical Distant Metastasis TNM Finding v8 (Laryngeal Cancer Clinical TNM Finding v8)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Hard to Turn During Night (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)", + "output": "your overall Quality of Life (Findings-Based Question)" + }, + { + "input": "Definition: Gene or Genome described as human DAB2 wild-type allele is located within 5p13 and is approximately 52 kb in length. This allele, which encodes disabled homolog 2 protein, plays a role in the inhibition of cell proliferation. Down-regulation or complete loss of DAB2 gene expression is associated with certain cancers such as breast cancer and ovarian epithelial carcinomas.\nConcepts: Spiral Organ (Cochlear structure)\tmonilia; stomatitis (Inflammatory disorder of head)\tLight colored hair (Generalized hypopigmentation of hair)\tDOC2 (DAB2 gene)\tadult foraging behavior (foraging behavior)", + "output": "DOC2 (DAB2 gene)" + }, + { + "input": "Definition: Organic Chemical described as compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.\nConcepts: Primer, Oligonucleotide (Oligonucleotides)\tNegative Exponent (Quantitative Concept)\tCannabinoid - non-pharmaceutical (OTHER ANALGESICS AND ANTIPYRETICS in ATC)\tLN145 (Therapeutic Tumor Infiltrating Lymphocytes)\tpurine ribonucleoside triphosphate metabolism (purine nucleoside triphosphate metabolic process)", + "output": "Cannabinoid - non-pharmaceutical (OTHER ANALGESICS AND ANTIPYRETICS in ATC)" + }, + { + "input": "Definition: positive regulation of T cell differentiation described as any process that activates or increases the frequency, rate or extent of alpha-beta T cell differentiation.\nConcepts: day*ug/mL/(mg/g) (Quantitative Concept)\tDescription (Research Activity)\ttherapeutic leukopheresis (Blood and blood product treatment)\tupregulation of alpha-beta T cell differentiation (regulation of alpha-beta T cell differentiation)\tECG Planned Primary Lead (Idea or Concept)", + "output": "upregulation of alpha-beta T cell differentiation (regulation of alpha-beta T cell differentiation)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide.\nConcepts: segment polarity determination (Organ or Tissue Function)\tregulation of neutrophil mediated killing of symbiont cell (regulation of response to external stimulus)\ttest scores (Thesaurus of Psychological Index Terms)\thydroxy-nicotine oxidase activity (Molecular Function)\tCystological Tables (Medical Device)", + "output": "hydroxy-nicotine oxidase activity (Molecular Function)" + }, + { + "input": "Definition: Immunodeficiency associated with chromosomal abnormality described as a rare genetic immunodeficiency due to a complement cascade protein anomaly characterised by low or undetectable serum ficolin 3 levels, susceptibility to infections and possibly autoimmunity. The presentation is variable, from perinatal necrotising enterocolitis and recurrent skin infections with Staphylococcus aureus to childhood-onset recurrent pulmonary infections leading to brain abscesses and pulmonary fibrosis, to membranous nephropathy. In some patients clinical consequences of ficolin 3 deficiency were not clear. There is evidence that ficolin 3 deficiency is caused by homozygous mutation in the FCN3 gene on chromosome 1p36.\nConcepts: alpha Synuclein (nerve/myelin protein)\timmunodeficiency due to ficolin 3 deficiency (Congenital Immunodeficiency Diseases)\tDEVICE, AUTOMATED CELL-LOCATING (Medical Device)\tEnglish Plantain Pollen IgG4 (Laboratory Procedure)\tUHDR163 (UHDRS 1999 Version Clinical Classification Question)", + "output": "immunodeficiency due to ficolin 3 deficiency (Congenital Immunodeficiency Diseases)" + }, + { + "input": "Definition: something described as tuberculosis of the brain, spinal cord, or meninges (TUBERCULOSIS, MENINGEAL), most often caused by MYCOBACTERIUM TUBERCULOSIS and rarely by MYCOBACTERIUM BOVIS. The infection may be limited to the nervous system or coexist in other organs (e.g., TUBERCULOSIS, PULMONARY). The organism tends to seed the meninges causing a diffuse meningitis and leads to the formation of TUBERCULOMA, which may occur within the brain, spinal cord, or perimeningeal spaces. Tuberculous involvement of the vertebral column (TUBERCULOSIS, SPINAL) may result in nerve root or spinal cord compression.\nConcepts: BCL3 Gene (Gene or Genome)\tpositive regulation of mRNA alternative polyadenylation (regulation of mRNA alternative polyadenylation)\tcns tuberculosis (Nervous system infections NEC)\tTCL3 (Gene or Genome)\tMitral Regurgitant Jet Area to Left Atrial Area Ratio (Cardiovascular finding)", + "output": "cns tuberculosis (Nervous system infections NEC)" + }, + { + "input": "Definition: MicroRNA Gene described as this gene is involved in the regulation of gene expression and plays a potential tumor suppressor role in chronic lymphocytic leukemia and chronic myeloid leukemia..\nConcepts: IVD Test Reagent/Kits, Serology, Parasite, Trichomonas Species, Antigen (Medical Device)\tMicroRNA 15b Gene (MicroRNA Gene)\tPULM ADENOMATOSIS (Epithelial Neoplasm)\tLUPARTUMAB AMADOTIN (Pharmacologic Substance)\tCervical Rib (Bone structure of rib)", + "output": "MicroRNA 15b Gene (MicroRNA Gene)" + }, + { + "input": "Definition: something described as a PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer of amino group of L-LYSINE onto 2-oxoglutarate to generate 2-aminoadipate 6-semialdehyde and L-GLUTAMATE.\nConcepts: Lysine epsilon Aminotransferase (Amino Acid, Peptide, or Protein)\tCHONDROSARCOMA, MALIGNANT (Primary malignant neoplasm)\thypnoTx pn mgmt ndvdl ea.15m (Hypnotherapy and/or meditation)\tgeneralizability (Classification)\theterochronic regulation of development (Organism Function)", + "output": "Lysine epsilon Aminotransferase (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as any process that activates or increases the rate or extent of mRNA splicing via a spliceosomal mechanism.\nConcepts: Scaphoid (Deformity)\tIL-2-RA (Receptor)\texpandedAccessIndicator (Indicator)\tCO (Mountain States)\tpositive regulation of mRNA splicing, via spliceosome (positive regulation of mRNA processing)", + "output": "positive regulation of mRNA splicing, via spliceosome (positive regulation of mRNA processing)" + }, + { + "input": "Definition: Trichechus described as member of the genus Trichechus inhabiting the coast and coastal rivers of the southeastern United States as well as the West Indies and the adjacent mainland from Vera Cruz, Mexico to northern South America.\nConcepts: Ventricular fibrillation (Heart)\tTwisted cerebral arteries (Finding)\tEuropean Quality of Life Five Dimension Three Level Scale Questionnaire Test Name (Intellectual Product)\tFood Safety (Food and Nutrition)\tCaribbean Manatees (Mammal)", + "output": "Caribbean Manatees (Mammal)" + }, + { + "input": "Definition: Finding described as a disorder characterized by repeated gulp sounds that result from an involuntary opening and closing of the glottis. This is attributed to a spasm of the diaphragm.\nConcepts: glomerulosclerosis focal segmental due to sickle cell disease (Focal glomerulosclerosis)\tskin structure of buttock (Skin of pelvic girdle)\tHiccups (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)\tExcessive Sucking (Finding)\tNon-Sterile Volumetric Powder Filling Method (Laboratory Procedure)", + "output": "Hiccups (Respiratory, Thoracic and Mediastinal Disorders, CTCAE)" + }, + { + "input": "Definition: something described as a sensation of tightness in a finger joint when attempting to move it, especially after a period of inactivity. []\nConcepts: Fingers stiffness (Sign or Symptom)\tresponse to increased oxygen levels (Cell Function)\tnegative regulation of netrin-activated signalling pathway (regulation of netrin-activated signaling pathway)\tdendritic spine organization (postsynapse organization)\tREV CONCURRENT (Occupational Activity)", + "output": "Fingers stiffness (Sign or Symptom)" + }, + { + "input": "Definition: Immune Response, Mucosal described as immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes.\nConcepts: ddRNAi (Molecular Biology Research Technique)\tsperm count (Sperm Count Procedure)\tSCF-Das1 ubiquitin ligase complex (Cell Component)\tDKFZp547H118 (Gene or Genome)\timmune response in MALT (Immune Response, Mucosal)", + "output": "immune response in MALT (Immune Response, Mucosal)" + }, + { + "input": "Definition: Neoplastic Process described as spinal cord neoplasm resistant to treatment.\nConcepts: Clippers, Hair (Personal effects)\tnegative regulation of production of molecular mediator of immune response (regulation of production of molecular mediator of immune response)\tBehavior management: overactivity/inattention (Behavior management)\tdown regulation of lipoprotein metabolic process (negative regulation of cellular metabolic process)\tRefractory Spinal Cord Tumor (Refractory Primary Central Nervous System Neoplasm)", + "output": "Refractory Spinal Cord Tumor (Refractory Primary Central Nervous System Neoplasm)" + }, + { + "input": "Definition: Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8 described as stage IIE: Contiguous extralymphatic extension from a nodal site with or without involvement of other lymph node regions on the same side of the diaphragm.\nConcepts: Cardia (Body Location or Region)\tOncocytoma of kidney (Kidney Neoplasm)\trnrx positioning therapy (Immobility Management)\tLugano Classification Stage IIE Hodgkin Lymphoma AJCC v8 (Neoplastic Process)\tDental caries (Finding)", + "output": "Lugano Classification Stage IIE Hodgkin Lymphoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Geographic Area described as a group of islands in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand.\nConcepts: CK (Country)\tpositive energy taxis (Cell Function)\tSwollen Glands (Infection status)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Borrelia burgdorferi, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Borrelia burgdorferi)\tBiotope CD (Pharmacologic Substance)", + "output": "CK (Country)" + }, + { + "input": "Definition: Classification described as a term that refers to the cellular differentiation of a malignant cellular infiltrate. A cancer is defined through grades I-IV (or 1-4), or as well, moderately, poorly differentiated or undifferentiated.\nConcepts: Disease Grade Qualifier (Classification)\tUHDR1-Saccade Velocity: Vertical (Intellectual Product)\tTravel Nursing (Biomedical Occupation or Discipline)\tgamma1-MSH (Hormone)\tDehalococcoides (Bacterium)", + "output": "Disease Grade Qualifier (Classification)" + }, + { + "input": "Definition: Machine Activity described as computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.\nConcepts: GTP:GDP antiporter activity (anion:anion antiporter activity)\tSignal processing (Computing Methodologies)\tganglia structural organization (Morphogenesis)\tIVD Test Reagent/Kits, Clinical Chemistry, Catecholamine Metabolite, Homovanillic Acid (Medical Device)\tFUS/CREB3L1 Fusion Gene (Fusion Gene)", + "output": "Signal processing (Computing Methodologies)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a family of cysteine-rich proteins that bind to and transport heavy metal ions.\nConcepts: ACCESSORY EQUIPMENT, CARDIOPULMONARY BYPASS (Medical Device)\tHIV-1 Group O Antibody (HIV Antibody Measurement)\tMammary analog secretory carcinoma (Carcinoma)\tNozzle Tip Device (Device tip)\tmetallothioneins (Amino Acid, Peptide, or Protein)", + "output": "metallothioneins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene.\nConcepts: gamma-hexachlorocyclohexane dehydrochlorinase activity (carbon-halide lyase activity)\tluteinizing hormone signaling pathway (Organ or Tissue Function)\tLaser Interstitial Thermal Therapy (Thermal ablation)\tCHRONAXIMETER (Stimulator)\tFluvoxamine (Serotonin Uptake Inhibitors)", + "output": "gamma-hexachlorocyclohexane dehydrochlorinase activity (carbon-halide lyase activity)" + }, + { + "input": "Definition: something described as an organization based in Leiden, Netherlands that coordinates the collection of HLA phenotypes from volunteer stem cell donors and cord blood donors, and is responsible for coordination of their distribution worldwide.\nConcepts: Health-Related Quality Of Life (Perceived quality of life)\tSexual function (Urinary Tract Physiology)\tBone Marrow Donors Worldwide (Professional Organization or Group)\tacetyl-CoA metabolism (Molecular Function)\tPQL03-Wake Up Tired (PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question)", + "output": "Bone Marrow Donors Worldwide (Professional Organization or Group)" + }, + { + "input": "Definition: Soft Tissue Neoplasms described as a benign or malignant mesenchymal neoplasm of the uterine corpus. Representative examples include leiomyoma, leiomyosarcoma, and endometrial stromal sarcoma.\nConcepts: Uterine Corpus Soft Tissue Neoplasm (Neoplasm of body of uterus)\tUrachus: [patent] or [persistent] (Skin disorder of umbilicus)\tENDOILLUMINATOR (Medical Device)\tC EBPalpha (Amino Acid, Peptide, or Protein)\tRadiation Therapy Oncology Group (Health Care Related Organization)", + "output": "Uterine Corpus Soft Tissue Neoplasm (Neoplasm of body of uterus)" + }, + { + "input": "Definition: stage, renal cell cancer described as a renal cell carcinoma that occurs during childhood.\nConcepts: ubiquitin thiolesterase 6, human (Amino Acid, Peptide, or Protein)\tSUBLINGUAL GLANDS (Salivary Glands)\ttransient receptor potential cation channel, subfamily P, member 1 (Gene or Genome)\tabdominal cavity (Subdivision of abdominal compartment)\tPediatric Kidney Cell Carcinoma (stage, renal cell cancer)", + "output": "Pediatric Kidney Cell Carcinoma (stage, renal cell cancer)" + }, + { + "input": "Definition: Finding described as an indication that signs of metastasis were not found in a sample.\nConcepts: UDHR1-Delusions: Severity (Intellectual Product)\tMetastasis Negative (Finding)\tchemical genetics (Biomedical Occupation or Discipline)\tProstate Cancer cT3b TNM Finding v8 (Prostate Cancer cT3 TNM Finding v8)\tAU RNA Binding Protein/Enoyl-Coenzyme A Hydratase wt Allele (AUH gene)", + "output": "Metastasis Negative (Finding)" + }, + { + "input": "Definition: Stomach described as a portion of the digestive system of birds, insects and invertebrates lying between the crop and the gizzard. It is responsible for the secretion of gastric enzymes and moving food into the gizzard.\nConcepts: Anti-CEACAM6 AFAIKL2 Antibody Fragment/Jack Bean Urease Immunoconjugate L-DOS47 (Immunoconjugates)\tGRAM-NEGATIVE MICROAEROPHILIC COCCUS (Bacterium)\tANTIGENS, HA (INCLUDING HA CONTROL), REOVIRUS 1-3 (Indicator, Reagent, or Diagnostic Aid)\tHave Numbness or Tingling in Feet (Findings-Based Question)\tPROVENTRICULUS (Body Part, Organ, or Organ Component)", + "output": "PROVENTRICULUS (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: L-alanine transmembrane transport described as the directed movement of L-alanine from inside of a cell, across the plasma membrane and into the extracellular region.\nConcepts: Concentrate for Solution for Injection/Infusion Dosage Form (Biomedical or Dental Material)\tParaganglioma of the Cauda Equina (Neoplastic Process)\tNoninvasive Blood Pressure Monitors (Pressure monitor)\tAnterior Gradient 2 Homolog Gene (Gene or Genome)\tL-alanine export across the plasma membrane (L-alanine transmembrane transport)", + "output": "L-alanine export across the plasma membrane (L-alanine transmembrane transport)" + }, + { + "input": "Definition: Ophthalmic Agents described as a synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intraocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes). It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.\nConcepts: Plants, Huckleberry (Plant)\tSpiculated/Serrated (Nodule Margin Type)\tIPA03-Sitting Weekday Hours per Day (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tNucleic Acid Bond (Molecular Structure)\t5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))- (Organic Chemical)", + "output": "5-Heptenamide, 7-(3,5-dihydroxy-2-(3-hydrdoxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-, (1R-(1alpha(Z),2beta(1E,3S*),3alpha,5alpha))- (Organic Chemical)" + }, + { + "input": "Definition: T-cell Receptor-engineered T-cells described as human autologous peripheral blood lymphocytes (PBLs) transduced with a glycoprotein 100 (gp100) epitope-determined T cell receptor (TCR) gene, with potential antineoplastic activity. PBLs are isolated from a melanoma patient and pulsed with a viral vector encoding the TCR specific for amino acid residues 154-162 of gp100 (KTWGQYWQV). After expansion ex vivo, the transduced autologous PBLs, expressing this specific TCR, are reintroduced into the patient and bind to melanoma cells expressing the gp100 protein, which may result in specific cytotoxic T-lymphocyte (CTL) killing of gp100-expressing melanoma cells. gp100 is a melanocyte lineage-specific antigen overexpressed in melanomas.\nConcepts: Rats, Mutant Strains (Mammal)\tsharks (Elasmobranchii)\tMiHA-loaded PD-L-silenced DC Vaccine (Dendritic Cell Vaccine)\tAutologous Anti-gp100:154-162 TCR Gene-Engineered PBL (T-cell Receptor-engineered T-cells)\tDissatisfaction with Appearance When Dressed (Intellectual Product)", + "output": "Autologous Anti-gp100:154-162 TCR Gene-Engineered PBL (T-cell Receptor-engineered T-cells)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Number of errors during the executive function maze task.\nConcepts: PEG SN38 DFP-13318 (Pharmacologic Substance)\tELISA/ACT(R) Screening Dander Hair Feather Block each test (Allergy testing)\tLGALS7A (LGALS7 gene)\tInsufficient Evidence for Preeclampsia (Intellectual Product)\tCDISC ADAS-Cog - Executive Function Maze: Errors (Intellectual Product)", + "output": "CDISC ADAS-Cog - Executive Function Maze: Errors (Intellectual Product)" + }, + { + "input": "Definition: Pharmacologic Substance described as helium.\nConcepts: helium homeopathic preparation (Homeopathic remedies letter H)\tthreonine-type peptidase activity (Molecular Function)\tPatrinia jatamansi D.Don (Oils, Volatile)\tregulation of interleukin-32 biosynthetic process (Cell Function)\tParatesticular Adenomatoid Tumor (Paratesticular tumor)", + "output": "helium homeopathic preparation (Homeopathic remedies letter H)" + }, + { + "input": "Definition: Intellectual Product described as asthma Daytime Symptom Diary v1.0 - Please rate your wheezing at its worst since you got up this morning.\nConcepts: Chromaffin tumor (Paraganglioma)\tUrogenital Prolapses (Pelvic prolapse conditions)\tIRT User Notf (Document type)\tInterferon Regulatory Factor 7 wt Allele (Gene or Genome)\tADSD01-Rate Wheezing at Its Worst (Intellectual Product)", + "output": "ADSD01-Rate Wheezing at Its Worst (Intellectual Product)" + }, + { + "input": "Definition: Professional or Occupational Group described as a psychologist who specializes in geropsychology, which applies the knowledge and methods of psychology to understanding and helping older persons and their families to maintain well-being, overcome problems and achieve maximum potential during later life. Professional geropsychology appreciates the wide diversity among older adults, the complex ethical issues that can arise in geriatric practice and the importance of interdisciplinary models of care.\nConcepts: rnrx dialysis care (rnax urinary elimination)\thepoxilin anabolism (long-chain fatty acid biosynthetic process)\t2q12 (Chromosome band)\tPorcine enterovirus, NOS (Family Picornaviridae)\tPsychologist; Adult Development & Aging (Psychologist)", + "output": "Psychologist; Adult Development & Aging (Psychologist)" + }, + { + "input": "Definition: something described as the dorsal tegmental nucleus, the ventral tegmental nucleus and the cuneiform nucleus of the midbrain reticular formation ( Carpenter-1983 ).\nConcepts: Malignant Fibrous Histiocytoma of Skin (Malignant fibrohistiocytic tumor of skin)\tParticipatory Research, Community-Based (Research Activity)\tNuclei tegmenti (Body Part, Organ, or Organ Component)\tECG Used Same Lead (Finding)\tThoracic Esophagus Adenocarcinoma (Neoplastic Process)", + "output": "Nuclei tegmenti (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a measurement that describes the amount of heat inside the body.\nConcepts: temperature [use subs for data entry] (Taking vital signs)\tcells nucleated (Cell)\tPleural Biphasic Mesothelioma (Mesothelioma, biphasic, malignant)\tCaustic alkali (substance) [Ambiguous] (Alkalies)\taminolevulinic acid (Biologically Active Substance)", + "output": "temperature [use subs for data entry] (Taking vital signs)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as insertion or assistance with insertion and stabilization of an artificial airway\nConcepts: GDS02-Feel Worthless (Intellectual Product)\tSevere congenital hypochromic sideroblastic anaemia (Hereditary Diseases)\tPrint Ad (Intellectual Product)\tactin filament organisation involved in mitotic actomyosin contractile ring assembly (mitotic cell cycle process)\tAirway insertion and stabilisation (Stabilization)", + "output": "Airway insertion and stabilisation (Stabilization)" + }, + { + "input": "Definition: Adhesive Strips, Multipurpose described as multipurpose adhesive strips made of materials (e.g., latex-free) and/or covered with adhesives that are associated with a lower potential for producing an allergic reaction (i.e., hypoallergenic). These strips typically are short (usually less than 4 inches/10 cm) length and narrow (typically 1 to 2 inches/2.5 to 5 cm) flexible strips evenly covered on one side with pressure-sensitive adhesive. Hypoallergenic adhesive strips are intended for single use (i.e., disposable); they are usually supplied in precut sizes and/or shapes that may be packaged sterile. These devices are mainly intended to cover small wounds and/or to attach objects (e.g. dressings) to the skin in patients sensitive to standard strips and in other patients.\nConcepts: 6-PGL (carboxylic ester hydrolase activity)\tintramolecular proline-rich region binding (protein self-association)\tClinical Trial Stakeholder Communication Plan (Intellectual Product)\tSoft tissue sarcomas (Malignant musculoskeletal and connective tissue neoplasms)\tAdhesive Strips, Multipurpose, Hypoallergenic (Adhesive Strips, Multipurpose)", + "output": "Adhesive Strips, Multipurpose, Hypoallergenic (Adhesive Strips, Multipurpose)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter R described as wu bei zi\nConcepts: Rhi chinensis / wu bei zi (Oriental herbs and natural substances letter R)\tOsborne waves (Finding)\tStage IV Oral Cavity Squamous Cell Carcinoma (Neoplastic Process)\tPostnatal microcephaly (Microcephaly)\tH2A Histone Family, Member A Gene (H2AC8 Gene)", + "output": "Rhi chinensis / wu bei zi (Oriental herbs and natural substances letter R)" + }, + { + "input": "Definition: Immune System Phenomena described as any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.\nConcepts: Mouse Model of Colon Adenocarcinoma (Adenocarcinoma of the Mouse Intestinal Tract)\tAdjuvant Post-operative Radiation Therapy Administration Unknown (CPTAC Responses)\tComplement activation (Immune status)\tlysophospholipid:sodium symporter activity (phospholipid transporter activity)\tExternal granular layer of cerebral cortex (Tissue)", + "output": "Complement activation (Immune status)" + }, + { + "input": "Definition: something described as replace very hard, sticky or crunchy foods with those that are soft and moist. Treatment for dental problems and mouth soreness. (Source: Nutrition Care Manual, Academy of Nutrition and Dietetics 2013).\nConcepts: Diagnosis-Related Group Outliers (Diagnosis-Related Groups)\tCraniometadiaphyseal dysplasia wormian bone type (Schwartz-Lelek syndrome)\tUNQ26 (DNER gene)\tRestlessness, Psychomotor (Level of depression)\tEasy to chew diet (Therapeutic or Preventive Procedure)", + "output": "Easy to chew diet (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Disorder of trace mineral metabolism described as a myodegeneration most frequent in calves and lambs whose dams have been fed during gestation or longer on feeds, especially legumes (FABACEAE), grown in certain areas where selenium is either deficient or unavailable in the soil. It has been recorded in many countries. It has been produced experimentally in several species of animals on low-selenium intake. A similar myopathy occurs naturally in goats, deer, foals, and dogs but proof of the etiology is lacking.\nConcepts: 1-((2S)-2-amino-4-(2,4-bis(trifluoromethyl)-5,8-dihydropyrido(3,4-d)pyrimidin-7(6H)-yl)-4-oxobutyl-5,5-difluoropiperidin-2-one (Organic Chemical)\tAbnormal Pelli Robson contrast sensitivity chart test (Finding)\tSkeletal white muscle disease (Muscular Dystrophy, Animal)\tIncreased circulating mead acid level (Finding)\tdown-regulation of smooth muscle cell proliferation (regulation of smooth muscle cell proliferation)", + "output": "Skeletal white muscle disease (Muscular Dystrophy, Animal)" + }, + { + "input": "Definition: Esophageal Diseases described as a pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.\nConcepts: Diverticulosis;esophagus (Esophageal Diseases)\tMEDIA, REUSABLE IMAGE (Medical Device)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ACTA2 (Medical Device)\tserum reaction (Skin lesion)\tGenual joint (Structure of condylar joint)", + "output": "Diverticulosis;esophagus (Esophageal Diseases)" + }, + { + "input": "Definition: Membrane Proteins described as a major integral transmembrane protein of the ERYTHROCYTE MEMBRANE. It is the anion exchanger responsible for electroneutral transporting in CHLORIDE IONS in exchange of BICARBONATE IONS allowing CO2 uptake and transport from tissues to lungs by the red blood cells. Genetic mutations that result in a loss of the protein function have been associated with type 4 HEREDITARY SPHEROCYTOSIS.\nConcepts: Erythroid Anion Exchange Protein (Integral Membrane Proteins)\tMSQL1-Did You Feel Rested on Waking (Intellectual Product)\tUrsodeoxycholic acid product (Bile Acid [EPC])\tcell-cell junction disassembly (cell junction disassembly)\tcancer/testis antigen 3 (Gene or Genome)", + "output": "Erythroid Anion Exchange Protein (Integral Membrane Proteins)" + }, + { + "input": "Definition: Funding Mechanism described as a financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.\nConcepts: Research Grants (Funding Mechanism)\tneuroendocrinology (Science of neurophysiology)\tCardiovascular System Findings Time Point Reference (Reference Time Point)\tembolism; dialysis catheter (Pathologic Function)\tAnaplastic pleomorphic xanthroastrocytoma (Neoplastic Process)", + "output": "Research Grants (Funding Mechanism)" + }, + { + "input": "Definition: Medical Device described as digital radiographic systems designed for radiography of the breast (i.e., mammography). These systems usually include a high-frequency, constant-potential x-ray generator (usually with a voltage ranging from 20 to 35 kV); an automatic exposure control device; filters; a collimator; patient positioning features (e.g., compression devices); and a digital imaging system. Typically, the digital imaging system consists of a phosphor imaging plate used to obtain a latent image, which is scanned with a laser and digitized in an analog-to-digital converter. Digital mammographic systems are specifically intended for imaging the breast; they are used for screening and/or assessment of breast lesions.\nConcepts: Cancer Surveillance Research Program (Cancer Surveillance Research)\tCarlsbad aqua / water from Muehlbrunnen mineral springs (Inorganic Chemical)\tRiluzole (R [Preparations])\tMammography Digital Radiographic Systems (Radiographic Systems, Digital)\tinhibited sexual desire (Libido)", + "output": "Mammography Digital Radiographic Systems (Radiographic Systems, Digital)" + }, + { + "input": "Definition: Sutures, Natural, Nonabsorbable described as nonabsorbable natural sutures made of twisted long cotton fibers. Cotton sutures lose about 50% of their tensile strength in a six-month period and become encapsulated within body tissues. These sutures are typically available in sterile multifilament braided thread sections (e.g., 18, 30 in [45, 76 cm] long) attached to a single-use needle as an integral device; they are frequently colored for easy identification during surgery. Their intended use includes suturing internal organs, tissues, and vessels (e.g., in nephrostomy procedures); their current use is limited due to their low strength and occasional adverse reactions within tissues.\nConcepts: MAPKKK1 (MAP3K1 gene)\taminoglycoside 3''-adenylyltransferase activity (aminoglycoside nucleotidyltransferase activity)\tdownregulation of orcinol biosynthetic process (regulation of orcinol biosynthetic process)\tCotton suture (Sutures, Natural, Nonabsorbable)\tSteroid Sulfatase Activity (Laboratory Procedure)", + "output": "Cotton suture (Sutures, Natural, Nonabsorbable)" + }, + { + "input": "Definition: Transformers described as constant-voltage transformers designed to deliver energy to the lamp (e.g., halogen) of some rigid endoscopes (e.g., otoscopes, ophthalmoscopes) and illuminators (e.g., larynx, nasopharynx). These transformers are usually connected to the line voltage (e.g., 120 V, 240 V) at the input and deliver a low voltage (e.g., 2.5 V) at the output. Endoscopic constant-voltage transformers are used to deliver a steady voltage to endoscopic lights, thus providing constant illumination while performing diagnosis or other medical procedures. Some of these transformers are also capable of delivering enough power to operate an electrocautery unit.\nConcepts: photosystem I reaction center location (Cell Component)\tincreased bone density (Vertebral column)\tCarbonic acid, dilithium salt (Pharmacologic Substance)\tAclacinomycin-A (Antibiotic)\tEndoscopic Power Supplies, Line Operated (Electromechanical Devices)", + "output": "Endoscopic Power Supplies, Line Operated (Electromechanical Devices)" + }, + { + "input": "Definition: something described as human experimentation that is intended to benefit the subjects on whom it is performed.\nConcepts: Genetic anticipation with paternal anticipation bias (Anticipation, Genetic)\tSibling support (Childrearing Care)\turidine diphosphoglucose-ketone cyanohydrin glucosyltransferase activity (Molecular Function)\tHUMAN EXPERIMENTATION THER (Research Activity)\tmesonephric renal vesicle morphogenesis (Organ or Tissue Function)", + "output": "HUMAN EXPERIMENTATION THER (Research Activity)" + }, + { + "input": "Definition: Intellectual Product described as unified Huntington's Disease Rating Scale '99 - Disruptive or aggressive behavior: Frequency: Within the past month, how often have you had emotional or temper outbursts? How often have you had times when you lost control of yourself?\nConcepts: How Often Erection with Sexual Stimulation Hard Enough for Penetration (Intellectual Product)\tUHDR131A (Intellectual Product)\tprotein localisation in meiotic spindle pole body (meiotic cell cycle process)\tBacterial Chromatophores (Cell Component)\t19: 10375271-10362809 (Spatial Concept)", + "output": "UHDR131A (Intellectual Product)" + }, + { + "input": "Definition: Temporal Concept described as occurring in or characterized by only one phase or stage.\nConcepts: Monophasic (Time patterns)\tKingdom of Thailand (Asia, Southeastern)\tOttoman Empire (Geographic Area)\tBronchiolar non-ciliated cell (Cells)\tPIVC (Body Part, Organ, or Organ Component)", + "output": "Monophasic (Time patterns)" + }, + { + "input": "Definition: carbohydrate derivative biosynthetic process described as the chemical reactions and pathways resulting in the formation of a D-glycero-D-manno-heptose 7-phosphate.\nConcepts: D-glycero-D-manno-heptose 7-phosphate biosynthesis (Molecular Function)\tpositive regulation of rhodopsin gene expression (regulation of rhodopsin gene expression)\tScanning Electron Microscopy (ObservationMethod - CodeSystem)\tactivation of 17-methylnonadec-1-ene biosynthesis (positive regulation of cellular biosynthetic process)\tscrapie (Congenital anomaly of head)", + "output": "D-glycero-D-manno-heptose 7-phosphate biosynthesis (Molecular Function)" + }, + { + "input": "Definition: Individual Behavior described as personal actions to eliminate or reduce feelings of apprehension, tension, or uneasiness from an unidentifiable source\nConcepts: Were IV Narcotic/Opiate Agents Administered (CPTAC Questions)\tDiseases, Asperger (Developmental Disabilities)\tdown-regulation of intrinsic apoptotic signaling pathway in response to DNA damage (regulation of intrinsic apoptotic signaling pathway in response to DNA damage)\tAnxiety Self-Control (Self-control as a personality trait)\tGFRBSA (Laboratory Procedure)", + "output": "Anxiety Self-Control (Self-control as a personality trait)" + }, + { + "input": "Definition: Informational Intervention described as studies designed to examine associations, commonly, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures. The common types of analytic study are CASE-CONTROL STUDIES; COHORT STUDIES; and CROSS-SECTIONAL STUDIES.\nConcepts: tenocyte differentiation (Cell Differentiation process)\tProgressive (General adjectival modifier)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SACS (Medical Device)\tEpidemiological Studies (Informational Intervention)\tERBB2 (Genes)", + "output": "Epidemiological Studies (Informational Intervention)" + }, + { + "input": "Definition: Gene or Genome described as human SOST wild-type allele is located in the vicinity of 17q11.2 and is approximately 5 kb in length. This allele, which encodes sclerostin protein, is involved in the negative regulation of ossification. Mutation of the gene is associated with bone dysplasias including sclerosteosis type 1, van Buchem disease and craniodiaphyseal dysplasia autosomal dominant.\nConcepts: health care provider (licensed entity)\tQS-PARENT-DDS TEST (CDISC Questionnaire Terminology)\tSOST wt Allele (SOST gene)\tglycolytic process from mannose through fructose-6-phosphate (glycolytic process through fructose-6-phosphate)\tmiltiradiene catabolism (miltiradiene metabolic process)", + "output": "SOST wt Allele (SOST gene)" + }, + { + "input": "Definition: something described as a response indicating that a person requires no physical support.\nConcepts: Clostridium botulinum Toxin B5 (Pharmacologic Substance)\tTISSIERELLA PRAEACUTA (Clostridium)\tNone (Finding)\tLambda light chain measurement (Immunologic Tests)\tregulation of organic acid transport (Cell Function)", + "output": "None (Finding)" + }, + { + "input": "Definition: Time patterns described as passage through time; duration; a systematic or/and orderly succession; a sequence, e.g. course of treatment; a mode of action or behavior; natural development, typical manner of proceeding.\nConcepts: Moraxella osloensis (Moraxella )\tLamina muscularis mucosae intestini crassi (Structure of mucous membrane of cecum)\tcourse (Special disorder atoms)\tHydroxy acids (Carboxylic Acids)\tbreathing tests (laboratory studies)", + "output": "course (Special disorder atoms)" + }, + { + "input": "Definition: Obstetric Delivery described as extraction of the fetus by means of obstetrical instruments.\nConcepts: Extraction, Obstetrical (Therapeutic or Preventive Procedure)\tBPI - Warm Compresses to Relieve Pain (Intellectual Product)\tLVEF - Left ventricular ejection fraction (Left Ventricular Function)\tdownregulation of anion transport (negative regulation of ion transport)\tPrivate Label Distribution (Governmental or Regulatory Activity)", + "output": "Extraction, Obstetrical (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: chlorobenzene described as inhibits platelet aggregation\nConcepts: Clopidogrel-containing product (Platelet Aggregation Inhibitors)\tH4 (Histones)\tResponse Factor, Serum (Biologically Active Substance)\tCarcinoma of the Conjunctiva cM1 TNM Finding v7 (Finding)\tPharyngeal fistula (Head and Neck Fistula)", + "output": "Clopidogrel-containing product (Platelet Aggregation Inhibitors)" + }, + { + "input": "Definition: something described as a form of hereditary spastic paraplegia presenting with either a pure spastic paraplegia phenotype, usually in the first or second decade of life, with spastic lower extremities, unsteady spastic gait, hyperreflexia and extensor plantar responses, or as a complicated phenotype with the additional manifestations of distal wasting, saccadic ocular movements, mild cerebellar ataxia and mild, distal, axonal neuropathy.\nConcepts: Kawa Kawas (Piperaceae)\tLancefield group E,P,U,V strep (Bacterium)\tContainer.dimensionOneLabel (Intellectual Product)\tEx Vivo-activated Autologous Lymph Node Lymphocytes (therapeutic autologous lymphocytes)\tAutosomal spastic paraplegia type 30 (Autosomal hereditary disorder)", + "output": "Autosomal spastic paraplegia type 30 (Autosomal hereditary disorder)" + }, + { + "input": "Definition: regulation of cellular process described as any process that modulates the frequency, rate or extent of response to cell cycle checkpoint signaling.\nConcepts: MICL (oxo-acid-lyase activity)\tPipemidic Acid (Anti-Infective Agents, Urinary)\tQuackeries (Social Problems)\t2 (Quantitative Concept)\tregulation of response to cell cycle checkpoint signaling (regulation of response to biotic stimulus)", + "output": "regulation of response to cell cycle checkpoint signaling (regulation of response to biotic stimulus)" + }, + { + "input": "Definition: something described as chai hu\nConcepts: protein localization in actin fusion focus (protein localization to actin cytoskeleton)\tSuits, Space (Manufactured Object)\tBupleurum / chai hu (Plant)\tStage III Follicular Large Cell Lymphoma (Ann Arbor Stage III Aggressive Adult Non-Hodgkin Lymphoma)\tBird-headed dwarfism with features of premature senility (Disease or Syndrome)", + "output": "Bupleurum / chai hu (Plant)" + }, + { + "input": "Definition: FACT-G Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-General Version 4 - Emotional Well-Being: I worry about dying.\nConcepts: CTDSP2 wt Allele (CTDSP2 gene)\tQS-LEC-5 Standard Version TESTCD (CDISC Questionnaire Terminology)\tsestamibi scan (Diagnostic Procedure)\tFACT-G Version 4 - I Worry About Dying (Intellectual Product)\tParatracheal (Para-location)", + "output": "FACT-G Version 4 - I Worry About Dying (Intellectual Product)" + }, + { + "input": "Definition: Functional Concept described as a route used for extracorporeal haemodialysis where the product interacts with the patient blood through a semipermeable membrane.\nConcepts: Nuclear Sclerotic Cataract (Nuclear cataract)\tdebio 1347-101 (Organic Chemical)\tExtracorporeal haemodialysis route (Functional Concept)\tOpossum (Superorder Marsupalia)\tExtravascular Matrix Loops (Presence of Extravascular Matrix Patterns)", + "output": "Extracorporeal haemodialysis route (Functional Concept)" + }, + { + "input": "Definition: non-canonical Wnt signaling pathway involved in heart development described as any process that decreased the extent of cell adhesion that contributes to the shaping of the heart.\nConcepts: regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway (non-canonical Wnt signaling pathway involved in heart development)\tregulation of myeloid leukocyte mediated immunity (regulation of leukocyte mediated immunity)\ttrans-L-3-hydroxyproline dehydratase activity (Molecular Function)\tMobilizations, Lipid (Organ or Tissue Function)\tSynaptotagmins (Biologically Active Substance)", + "output": "regulation of cell adhesion involved in heart morphogenesis by non-canonical Wnt signalling pathway (non-canonical Wnt signaling pathway involved in heart development)" + }, + { + "input": "Definition: Professional or Occupational Group described as committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the \"Common Rule\") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.\nConcepts: Monitoring Committee, Data (Professional or Occupational Group)\tanklet (Technical Aids for the Disabled)\tflight (Locomotion)\tPerenial allergic rhinitis (Rhinitis)\tregulation of epidermis development (Organ or Tissue Function)", + "output": "Monitoring Committee, Data (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as cabinets designed to store, display, and provide ready access to dental instruments, devices, and materials (e.g., local anesthetics, cement) during dental treatments; they also have a working surface (e.g., the top of the cabinet) that may include a sink intended to facilitate the dental procedure. This furniture typically consists of a stand-alone, stainless steel multiple drawer, shelf, or shelf/drawer cabinet, they may have hinged or sliding (either glass or solid) doors. Dental cabinets may have attachments for handpieces, a high volume evacuator, and a saliva ejector; some also include built-in grounded outlets, security locks, and/or small wheels for easy movement. They are used in dental clinics and offices during the performance of dental procedures, including oral surgery.\nConcepts: Chronic Hemolysis (Hemolysis)\tGDP-L-fucose biosynthesis, salvage pathway (Molecular Function)\tDental cabinet (Dental equipment and devices)\tIntervention Required (Finding)\tskeletal muscle thin filament assembly (actin filament organization)", + "output": "Dental cabinet (Dental equipment and devices)" + }, + { + "input": "Definition: something described as this gene plays a role in the phosphorylation of transcription factors.\nConcepts: Chromatography Systems, Gas (Medical Device)\tGDS - Feel Downhearted and Blue (GDS Questionnaire Question)\tInterventricular septum endocardium (Endocardium of cardiac septum)\tHIPK2 (Serine/Threonine Protein Kinase Gene)\tWrite Code, Software Platform/Architecture, in Vitro Diagnostics Device (Occupational Activity)", + "output": "HIPK2 (Serine/Threonine Protein Kinase Gene)" + }, + { + "input": "Definition: Affiliate Realms described as a country in eastern Europe, bordering the Baltic Sea, between Latvia and Russia.\nConcepts: Lithuania (Geographic Area)\tCervical Cancer pT1b2 TNM Finding v8 (Finding)\tneoplasm of vertebra (Neoplasms by Site)\tPsychologies, Comparative (Psychology)\tHook Homolog 3 (Drosophila) wt Allele (Gene or Genome)", + "output": "Lithuania (Geographic Area)" + }, + { + "input": "Definition: proton-transporting V-type ATPase complex assembly described as the aggregation, arrangement and bonding together of a vacuolar proton-transporting V-type ATPase complex, proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across the vacuolar membrane.\nConcepts: Inhalator (Medical Device)\tMoxetumomab Pasudotox (Monoclonal Antibody/Antibody-Drug Conjugate)\tUrethral Undifferentiated Carcinoma (Neoplastic Process)\tvacuolar proton-transporting V-type ATPase complex assembly (proton-transporting V-type ATPase complex assembly)\tPAL activity (ammonia-lyase activity)", + "output": "vacuolar proton-transporting V-type ATPase complex assembly (proton-transporting V-type ATPase complex assembly)" + }, + { + "input": "Definition: Right coronary artery structure described as atrial branch of right coronary artery\nConcepts: Eccrine sweat gland (Sweat Glands)\tRight anterior atrial branch of right coronary artery (Right coronary artery structure)\tMeasuring device (Manufactured Object)\tInterspecific Recombination (Genetic Function)\tcellular response to sodium phosphate (Cell Function)", + "output": "Right anterior atrial branch of right coronary artery (Right coronary artery structure)" + }, + { + "input": "Definition: Yeasts described as a genus of ascomycetous fungi of the family Schizosaccharomycetaceae, order Schizosaccharomycetales.\nConcepts: Partial nephrectomy, laparoscopic with robot assistance (Therapeutic or Preventive Procedure)\tlarval salivary gland boundary specification (Organ or Tissue Function)\tthalictroides, Caulophyllum (Caulophyllum)\tBone marrow foam cells (Hematology)\tSchizosaccharomyces (Schizosaccharomycetaceae)", + "output": "Schizosaccharomyces (Schizosaccharomycetaceae)" + }, + { + "input": "Definition: Molecular Function described as the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid in the endoplasmic reticulum.\nConcepts: protein amino acid glycosylation in ER (Protein Glycosylation)\tCobalt-60 Radiation Therapy (Radionuclide therapy)\tIntraamniotic use (Functional Concept)\tdosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome (Genetic Function)\tHAMD 24 - Depressed Mood (Intellectual Product)", + "output": "protein amino acid glycosylation in ER (Protein Glycosylation)" + }, + { + "input": "Definition: I [Preparations] described as an active metabolite of MLN9708, a second generation, boron containing peptide proteasome inhibitor (PI) with potential antineoplastic activity. Ixazomib binds to and inhibits the 20S catalytic core of the proteasome, thereby blocking the targeted proteolysis normally performed by the proteasome, which results in an accumulation of unwanted or misfolded proteins; disruption of various cell signaling pathways may follow, resulting in the induction of apoptosis. Compared to first generation PIs, second generation PIs may have an improved pharmacokinetic profile with increased potency and less toxicity. Proteasomes are large protease complexes that degrade unneeded or damaged proteins that have been ubiquinated.\nConcepts: CYSLTR2 Gene Mutation (Gene Mutant)\tChronic dilatation of bronchus and bronchiole (Abnormal bronchus morphology)\tIxazomib (dichlorobenzene)\tCutaneous Malignant Melanoma 2 (Hereditary Melanoma)\tRefractory Rhabdoid Tumor of the Kidney (Refractory Childhood Malignant Neoplasm)", + "output": "Ixazomib (dichlorobenzene)" + }, + { + "input": "Definition: something described as diseases caused by MYXOMA VIRUS.\nConcepts: chromatin-mediated maintenance of transcription (positive regulation of gene expression, epigenetic)\tInfectious Myxomatosis (Disease or Syndrome)\tp53 Signaling Pathway KEGG (Molecular Function)\tCongenital dyserythropoietic anemia type IV (Autosomal dominant hereditary disorder)\tNPIPB8 wt Allele (NPIPB8 gene)", + "output": "Infectious Myxomatosis (Disease or Syndrome)" + }, + { + "input": "Definition: pyrimidine analog described as an antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.\nConcepts: Lime Oil (Organic Chemical)\tCells, Retinal Ganglion (Ganglia)\t2'-deoxy-5-fluorocytidine (Nucleic Acid, Nucleoside, or Nucleotide)\tRIB 2 (Body Part, Organ, or Organ Component)\t9-((2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl)guanine, Monosodium Salt (G [Preparations])", + "output": "2'-deoxy-5-fluorocytidine (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Functional Concept described as blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing this differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.\nConcepts: Hematopoietic cell lineage (Immune Response Regulation Pathway)\twriting micrographia (Finding)\tV. profunda linguae (Entire vein of head and neck)\tprotein transport into chloroplast thylakoid membrane (protein targeting to membrane)\tSIQ0223 (SIQ-JR Questionnaire Question)", + "output": "Hematopoietic cell lineage (Immune Response Regulation Pathway)" + }, + { + "input": "Definition: Dysplasia described as a morphologic finding indicating the presence of dysplastic changes in the transitional cell epithelium of the urinary tract.\nConcepts: pseudopseudohypoparathyroidism (Pseudohypoparathyroidism)\tUrothelial Dysplasia (Neoplastic Process)\tCalculate (Calculation)\tfamilial spastic paraplegia autosomal recessive type 48 (Spastic Paraplegia, Hereditary)\tHave Mood Swings (Intellectual Product)", + "output": "Urothelial Dysplasia (Neoplastic Process)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a transferrin immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the transferrin (an iron-binding and transporting serum protein) in serum, plasma, and other body fluids. Measurement of transferrin levels aids in the diagnosis of malnutrition, acute inflammation, infection, and red blood cell disorders, such as iron deficiency anemia.\nConcepts: hydrophilic (Behavior descriptors)\tcontractile actomyosin ring (contractile ring)\tbreast density (Anatomy Qualifier)\tTRANSFERRIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tchromicum acidum/chromic aci (Homeopathic remedies letter C)", + "output": "TRANSFERRIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as tumor necrosis factor receptor superfamily member 10B (440 aa, ~48 kDa) is encoded by the human TNFRSF10B gene. This protein is involved in the modulation of the caspase cascade.\nConcepts: gonadal dysgenesis (Congenital chromosomal disease)\tHyperinsulinism due to UCP2 deficiency (Hereditary disorder of endocrine system)\tTRAIL-R2 protein, human (Tumor Necrosis Factor Receptor)\tnaphthyl-2-methyl-succinate CoA-transferase activity (Molecular Function)\tmodification of synaptic structure (Cell Function)", + "output": "TRAIL-R2 protein, human (Tumor Necrosis Factor Receptor)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual is or was a little disrupted.\nConcepts: Angiogenesis Promoter (Biologically Active Substance)\tt(1;22)(p13.3;q13.1) (Chromosomal translocation)\tNPI1-Depression/Dysphoria Distress (Intellectual Product)\tcarpel morphogenesis (Biologic Function)\tA Little Disrupted (Clinical or Research Assessment Answer)", + "output": "A Little Disrupted (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as the developmental process pertaining to the initial formation of a metanephric cap from unspecified parts. The metanephric cap is formed by the condensation of metanephric mesenchymal cells surrounding the ureteric bud tip.\nConcepts: synthetic hTERT DNA vaccine INO-1400 (Immunologic Factor)\tCombined Pharmaceutical Dose Form (Intellectual Product)\tOrange Trees, Seville (Citrus plant)\tInhibin A (Recombinant Inhibins)\tmetanephric cap formation (Organ or Tissue Function)", + "output": "metanephric cap formation (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as a radiopharmaceutical agent composed of a dimeric cyclic arginine-glycine-aspartic acid (RGD)-based peptide (c[RGDyK]) and labeled, via the chelating agent 1,4,7-triazacyclononane,1-glutaric acid-4,7-acetic acid (NODAGA), with gallium Ga 68, with potential alphaVbeta3 (aVb3) integrin imaging activity upon positron emission topography (PET) or single photon emission computed tomography (SPECT). After intravenous administration of gallium Ga 68-NODAGA-E(c[RGDyK])2, the cyclic RGD moiety targets and binds to aVb3 integrin which is expressed on the cell membrane of tumor cells and tumor-resident endothelial cells. Upon imaging, aVb3 integrin-expressing cells can be visualized and expression levels can be quantified. This can be used to assess response to anti-angiogenic treatment. aVb3 integrin is overexpressed on certain tumor cells and tumor-resident endothelial cells, while minimally or not expressed on healthy, normal cells; aVb3 integrin plays a key role in angiogenesis, tumor proliferation and survival.\nConcepts: 68Ga-NODAGA-E(c[RGDyK])2 (Indicator, Reagent, or Diagnostic Aid)\tchromosome 7 ring syndrome (Chromosome replaced with ring or dicentric)\tparathyroid mixed cell type adenoma (cellular diagnosis, parathyroid cancer)\tTUMOR MERGED (Abnormal Finding)\tU-13C-Fructose (Radioconjugate)", + "output": "68Ga-NODAGA-E(c[RGDyK])2 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as a subjective score of 5 on a scale that ranges from 0: Health problems had no effect on my daily activities to 10: Health problems completely prevented me from doing my daily activities.\nConcepts: Ureteronephrectomy (Ureterectomy)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler - Get Hurt Accidentally (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)\tNCCN-FACT FBRSI-24 Version 2 - I Feel Fatigued (NCCN-FACT FBRSI-24 Version 2 Questionnaire Question)\tHealth Problems Effect on Daily Activities Score 5 (Clinical or Research Assessment Answer)\tAPPLICATOR, ENT DRUG (Medical Device)", + "output": "Health Problems Effect on Daily Activities Score 5 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Laboratory: serology described as anti-DNA antibodies: The presence of anti-DNA antibodies fulfills a diagnostic criterion for SLE, however, these antibodies may be seen in other illnesses. About 50% of SLE patients have anti-DNA antibodies and the antibodies correlate best with renal involvement.\nConcepts: Clinical Trial Protocols as Topic (Clinical Protocols)\tBladder (Body part)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, EPCAM (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tAnti-DNA antibodies, titer 1: (Laboratory: serology)\tRetro-Inverso Analogue (Amino Acid, Peptide, or Protein)", + "output": "Anti-DNA antibodies, titer 1: (Laboratory: serology)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify genetic variants associated with oculocutaneous albinism, a form of albinism in which pigmentation of the hair, skin, and eyes is affected. Genetic variants at multiple loci have been associated with oculocutaneous albinism. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple oculocutaneous albinism-associated loci simultaneously.\nConcepts: Segmental motor seizure (Epilepsy, Partial, Motor)\tRefractory Acute Graft Versus Host Disease (Acute GVH disease)\tOculocutaneous Albinism Gene Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Albinism)\tcarboxyltransferase/carbamoyltransferase (Enzyme)\tGastro-Resistant Tablet plus Rectal Suspension Dosage Form (Biomedical or Dental Material)", + "output": "Oculocutaneous Albinism Gene Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Albinism)" + }, + { + "input": "Definition: Finding described as a lack of coordination of arm movement manifested by undershoot or overshoot of the intended position of the arm.\nConcepts: 14r (area 14)\tSphenoidal sinus-chr. (Sphenoid Sinusitis)\tUpper limb dysmetria (Finding)\tCD331 (Gene Mutation)\tLewy body-like hyaline inclusion (Cell Component)", + "output": "Upper limb dysmetria (Finding)" + }, + { + "input": "Definition: Antibodies described as any immunoglobulin that recognizes Thomsen-Friedenreich antigen, a disaccharide, comprised of galactose and N-acetylgalactosamine, that is bound through O-linked glycosylation serine or threonine residues in mucin proteins.\nConcepts: Thomsen-Friedenreich Antigen Antibody (Amino Acid, Peptide, or Protein)\tdaphnetin 4-O-beta-glucosyltransferase activity (hexosyltransferase activity)\tAbsent/small skeletal muscles (Abnormality of muscle size)\tBordetella pertussis Serotype Fim 2/3 AB (Immunologic Tests)\tKilodyne per centimeter squared (Unit of cardiothoracic assessment)", + "output": "Thomsen-Friedenreich Antigen Antibody (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Population Group described as the person to whom data refers.\nConcepts: Convolvulus arvensis (Pharmacologic Substance)\tColumbia-Suicide Severity Rating Scale Baseline/Screening Version Questionnaire Test Name (CDISC Questionnaire Terminology)\tRipretinib (Antineoplastic Enzyme Inhibitor)\tdata subject (Population Group)\tUnresectable Digestive System Carcinoma (Neoplastic Process)", + "output": "data subject (Population Group)" + }, + { + "input": "Definition: Cupped ribs described as wide, concave posterior rib end.\nConcepts: Nephroureterectomy (Total nephrectomy)\tGeneralized hypoplasia of tooth enamel (Finding)\tPolydactyly, Preaxial I (Finding of thumb)\tPosterior rib cupping (Finding)\tPQL10-Hands Are Weak (Intellectual Product)", + "output": "Posterior rib cupping (Finding)" + }, + { + "input": "Definition: Genes described as a hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription). These can be created by chromosomal aberration or by laboratory methods.\nConcepts: Rsc8 (SMARCC2 gene)\teryngium aquaticum/button sn (Western herbs and natural substances letter E)\tDisorders, Borderline Personality (Other personality disorders)\t(2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol (Pharmacologic Substance)\tfusion gene (Genes)", + "output": "fusion gene (Genes)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: It is hard for our family to plan activities like vacations.\nConcepts: DNA template activity (DNA Binding)\tDensities, Population (Demography)\tPQL13-Hard for Family to Plan Activities (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)\tCarcinosarcoma NOS (COMPLEX MIXED AND STROMAL NEOPLASMS)\tUTD1 (Organic Chemical)", + "output": "PQL13-Hard for Family to Plan Activities (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question)" + }, + { + "input": "Definition: regulation of cellular respiration described as any process that modulates the frequency, rate or extent of methane biosynthetic process from formic acid.\nConcepts: regulation of methane biosynthetic process from formic acid (regulation of cellular ketone metabolic process)\tImmuno-Receptor Tyrosine-Based Inhibition Motif (Amino Acid Sequence)\tNearly Every Day for 2 Weeks (Clinical or Research Assessment Answer)\tMedication regimen (Therapeutic or Preventive Procedure)\tSPATA2 wt Allele (SPATA2 gene)", + "output": "regulation of methane biosynthetic process from formic acid (regulation of cellular ketone metabolic process)" + }, + { + "input": "Definition: something described as aspergillus spp. serological reagents are devices that consist of antigens and antisera used in various serological tests to identify antibodies to Aspergillus spp. in serum. The identification aids in the diagnosis of aspergillosis caused by fungi belonging to the genus Aspergillus. Aspergillosis is a disease marked by inflammatory granulomatous (tumor-like) lessions in the skin, ear, eyeball cavity, nasal sinuses, lungs, and occasionally the bones.\nConcepts: ANTIGEN, CF, ASPERGILLUS SPP. (Indicator, Reagent, or Diagnostic Aid)\tIschemic heart disease NOS (Non-Neoplastic Heart Disorder)\tpreprophase band (cellular anatomical entity)\tGastrointestinal Absorption Inhibition (Gastrointestinal Process)\t17p13 (Cell Component)", + "output": "ANTIGEN, CF, ASPERGILLUS SPP. (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Signaling Protein described as ribosomal protein S6 kinase alpha-2 (733 aa, ~83 kDa) is encoded by the human RPS6KA2 gene. This protein plays a role in the modulation of transcription, cellular proliferation, differentiation, and survival.\nConcepts: Sustained Release Oral Liquid Dose Form (Sustained Release Dosage Form)\tMAP Kinase-Activated Protein Kinase 1c (Signaling Protein)\tThiazides (Heterocyclic Compounds)\tC20orf2 protein, human (Biologically Active Substance)\tEmergency Care Information Systems (Intellectual Product)", + "output": "MAP Kinase-Activated Protein Kinase 1c (Signaling Protein)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as facilitating water exercise of clients in a group setting for therapeutic effect(s) (for example, to improve flexibility). Service is billed in 60-minute increments per client.\nConcepts: MLL-GMPS Fusion Protein (Fusion protein)\tparvum cryptosporidium (C [Preparations])\tWater exercise group each 60 minutes (aquatic activity)\tcapsorubin biosynthetic process (Molecular Function)\tActivated B-Lymphocytes Present (Abnormal Hematology Test Result)", + "output": "Water exercise group each 60 minutes (aquatic activity)" + }, + { + "input": "Definition: Necrosis described as separation of a portion of joint cartilage and of underlying bone due to loss of blood supply\nConcepts: Autologous Dendritic Cells Transduced with Wild-type p53 Adenovirus Vaccine (Immunologic Factor)\tRenal CL for Dose Int Norm by WT (Quantitative Concept)\tDissecans, Osteochondritis (Osteochondropathy)\tTGFbeta-activated receptor activity (Protein or Enzyme Type Measurement)\tcovert sensitization (Aversion Conditioning)", + "output": "Dissecans, Osteochondritis (Osteochondropathy)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of concentration (molarity unit) equal to one millionth of a mole (10E-6 mole) per kilogram of a substance per period of time equal to sixty seconds.\nConcepts: OS (Finding)\tIntervention for Kawasaki Disease Given Beyond Ten Days of Onset of Initial Symptoms (Other Finding)\tregulation of peptide hormone secretion (regulation of peptide secretion)\t3-(3-hydroxy)phenylpropionate breakdown (monocarboxylic acid catabolic process)\tumol/kg/min (Quantitative Concept)", + "output": "umol/kg/min (Quantitative Concept)" + }, + { + "input": "Definition: something described as a temper tantrum is an emotional outburst usually triggered by a sense of frustration and manifested as whining and crying, screaming, kicking, hitting, and breath holding. Temper tantrums are normal in toddlers and young children and usually happen between the ages of one to three years. Temper tantrums may be considered abnormal if they occur at an unusually high frequency, are of unusual severity, or occur at an old age than usual. []\nConcepts: positive regulation of centriole-centriole cohesion (regulation of centriole-centriole cohesion)\tAbnormal temper tantrums (Abnormal behavior)\tSoftware, Workstation Management, Healthcare, Registration/Administrative Data (Software, Workstation Management)\tYMRS - Content (Intellectual Product)\tThyrotropin Receptor Defect (Cell or Molecular Dysfunction)", + "output": "Abnormal temper tantrums (Abnormal behavior)" + }, + { + "input": "Definition: KDM1A gene described as human KDM1A wild-type allele is located in the vicinity of 1p36.12 and is approximately 64 kb in length. This allele, which encodes lysine-specific histone demethylase 1A protein, plays a role in the modulation both of histone methylation and transcription.\nConcepts: CYSTARCH (Chemical procedure)\tLeft superior pulmonary vein part of pericardial sac (Body Part, Organ, or Organ Component)\tAOF2 (Gene or Genome)\tRubrospinal tract of spinal cord (Body Part, Organ, or Organ Component)\tGATA Binding Factor-5 (Amino Acid, Peptide, or Protein)", + "output": "AOF2 (Gene or Genome)" + }, + { + "input": "Definition: VHL gene described as human VHL wild-type allele is located within 3p26-p25 and is approximately 10 kb in length. This allele, which encodes von Hippel-Lindau disease tumor suppressor protein, is involved in the regulation of protein ubiquitination and proteasomal targeting. Mutations in the gene are associated with von Hippel-Lindau syndrome.\nConcepts: RefSeq (Intellectual Product)\tHRCA1 (VHL gene)\tPainless fractures due to injury (Skeletal)\tCivaSheet Directional Pd103 Brachytherapy Source (Radiation Source -- device)\thost cell exit (exit from host)", + "output": "HRCA1 (VHL gene)" + }, + { + "input": "Definition: Idea or Concept described as the type of primary outcome or endpoint that the protocol is designed to evaluate.\nConcepts: Transthyretin cardiac amyloidosis (Senile cardiac amyloidosis)\tNLD - Necrobiosis lipoidica (Traumatic and/or non-traumatic injury of anatomical site)\tClinical Trial Type (Research Design)\tBAY 1238097 (BET Inhibitor)\tAbnormality of dorsoventral patterning of the limbs (Foot Deformities)", + "output": "Clinical Trial Type (Research Design)" + }, + { + "input": "Definition: something described as a core facility for the preparation and synthesis of organic molecules.\nConcepts: Dipstick device (Diagnostic, Therapeutic, and Research Equipment)\ttRNA (Carboxymethyluridine(34)-5-O)-Methyltransferase ABH8 (Amino Acid, Peptide, or Protein)\tQIDS-C - Early Morning Insomnia (Intellectual Product)\tSemicanalis musculi tensoris tympani (Ear conduit)\tOrganic Synthesis Facility (Manufactured Object)", + "output": "Organic Synthesis Facility (Manufactured Object)" + }, + { + "input": "Definition: Interleukin inhibitors described as a recombinant monoclonal antibody interleukin-2 receptor antagonist. Daclizumab binds specifically to the alpha subunit of the human interleukin-2 (IL-2) receptor expressed on the surface of activated lymphocytes in vivo, thereby inhibiting IL-2 binding and IL-2-mediated lymphocyte activation, a critical cellular immune response pathway. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1569\" active clinical trials using this agent.\nConcepts: Isocitrate Dehydrogenase [NADP] Cytoplasmic R132G (Cell or Molecular Dysfunction)\tO-decanoyltransferase activity (O-acyltransferase activity)\tPrebiotics (Dietary Fiber)\tBfa1-Bub2 complex (Cell Component)\tMonoclonal Antibody Anti-Tac (Monoclonal Antibodies)", + "output": "Monoclonal Antibody Anti-Tac (Monoclonal Antibodies)" + }, + { + "input": "Definition: something described as retaining the established polarization of a cell along its apical/basal axis.\nConcepts: maintenance of apical/basal cell polarity (establishment or maintenance of apical/basal cell polarity)\tQLES168 (Intellectual Product)\tUrine Sediment Analysis Measurement (Urine Chemistry Measurement)\tnicotinate nucleotide formation (nicotinate nucleotide metabolic process)\tCSS0119 (Intellectual Product)", + "output": "maintenance of apical/basal cell polarity (establishment or maintenance of apical/basal cell polarity)" + }, + { + "input": "Definition: Cell Function described as any process in which mitochondrial RNA is transported to, or maintained in, a specific location.\nConcepts: ILLUMINATOR, COLOR VISION PLATE (Medical Device)\tHow often has your loved one had a conversation with their oncologist about the likely outcome of their cancer over time (Clinical or Research Assessment Question)\tScanning Systems, Laser, Optical Coherence Tomography, Ophthalmic, Biometry (Medical Device)\tmitochondrial RNA localization (RNA localization)\tCIS Nations (Historical Geographic Locations)", + "output": "mitochondrial RNA localization (RNA localization)" + }, + { + "input": "Definition: something described as an indication that it is not known whether EGFR mutation analysis was performed during the study.\nConcepts: Monocular Blindness, Transient (Non-Neoplastic Eye Disorder)\tCognitive Change (Neurological observations)\thailey disease (Keratosis)\tNot Known if EGFR Mutation Analysis Was Performed (Not Known if Mutation Analysis Was Performed)\tpN1b Melanoma of Skin v6 (Cutaneous Melanoma pN1 TNM Finding v6)", + "output": "Not Known if EGFR Mutation Analysis Was Performed (Not Known if Mutation Analysis Was Performed)" + }, + { + "input": "Definition: Hematological Disease described as a benign tumor of the adrenal gland composed of adipocytes and hematopoietic/lymphoid cells.\nConcepts: Python regia (Pharmacologic Substance)\tType B1 (Classification)\tMYELOLIPOMA, BENIGN (lipoma of adipose tissue)\tCervical Carcinoma Pathologic TNM Finding v8 (Cervical Cancer TNM Finding v8)\tRight lung field/right chest (Finding)", + "output": "MYELOLIPOMA, BENIGN (lipoma of adipose tissue)" + }, + { + "input": "Definition: something described as a question about whether or not an individual had any irregular menstral periods.\nConcepts: Free Immunoglobulin Light Chain Measurement (Laboratory Procedure)\tPaced Tapping - Median Interval Self All (Paced Tapping Functional Test Question)\tPast Seven Days Any Irregular Menstrual Period (Intellectual Product)\tEndodermal Sinus Tumor (Malignant Neoplasms)\tsuperior cingulate gyrus (Body Part, Organ, or Organ Component)", + "output": "Past Seven Days Any Irregular Menstrual Period (Intellectual Product)" + }, + { + "input": "Definition: something described as ionizing radiation detectors designed for automated detection of high levels (typically up to 100 roentgen/hour or more) of ionizing radiation that are an immediate hazard to humans. These detectors may use one or several different technologies (e.g., scintillation). The detectors typically include visual and/or sound indicators that show when dangerous radiation levels are present; some permit a rough estimate of the radiation levels. These detectors do not include displays showing the radiation rate. High-level ionizing radiation detectors are used mainly by healthcare personnel, rescuers, firefighters, and military personnel in highly contaminated or potentially highly contaminated radioactive areas, as a result of atomic power plant leakage, nuclear explosion, or any other event involving high-energy ionizing radiation sources.\nConcepts: TRIM38 (Laboratory Procedure)\tDetectors, Environmental, Ionizing Radiation, High-Level (Detectors, Environmental, Ionizing Radiation)\tProtein HC (Immunologic Tests)\tModerately Severe Hallucination (Finding)\tATP breakdown (Metabolism)", + "output": "Detectors, Environmental, Ionizing Radiation, High-Level (Detectors, Environmental, Ionizing Radiation)" + }, + { + "input": "Definition: Organic Chemical described as six-carbon alicyclic hydrocarbons.\nConcepts: GAUGE, GAS PRESSURE, CYLINDER/PIPELINE (Medical Device)\tCDRS116A (Intellectual Product)\tlentigo maligna melanoma of skin (MISCELLANEOUS TUMORS)\tCyclohexanes (Organic Chemical)\tnorpregnane (Organic Chemical)", + "output": "Cyclohexanes (Organic Chemical)" + }, + { + "input": "Definition: Region of bladder described as the anterior aspect of the bladder wall.\nConcepts: Ventral wall of urinary bladder (Anterior wall of bladder)\tFormparanate (Acetylcholinesterase Inhibitors)\tAbnormal mineralization (Biological Processes)\thdlg (Membrane-Associated Guanylate Kinase Family Gene)\tCOD-MD Syndrome (Multisystem disorder G-H)", + "output": "Ventral wall of urinary bladder (Anterior wall of bladder)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in signal transduction.\nConcepts: Data Item Query (Intellectual Product)\tMHIS01-Total Score (Intellectual Product)\tRelation to Reference Period (Intellectual Product)\tSmall Nuclear Ribonucleoprotein Polypeptide F wt Allele (Gene or Genome)\tRho guanine nucleotide exchange factor (GEF) 28 (Gene or Genome)", + "output": "Rho guanine nucleotide exchange factor (GEF) 28 (Gene or Genome)" + }, + { + "input": "Definition: something described as large scale propagation of microscopic organisms such as viruses, bacteria, protozoa, fungi, etc in vitro in special media or host cells conducive to their growth.\nConcepts: 3',5'-dimethoxy-4-stilbenol (SY); 3,5-dimethoxy-4'-hydroxystilbene (Pharmacologic Substance)\tDevice Observer Serial Number (Identifier)\tbiotinylation (Metabolism)\tmicroorganism mass culture (microorganism culture)\tHair Part (Integumentary system part)", + "output": "microorganism mass culture (microorganism culture)" + }, + { + "input": "Definition: Enzyme described as peptidyl-prolyl cis-trans isomerase A (165 aa, ~18 kDa) is encoded by the human PPIA gene. This protein plays a role in cyclosporin-mediated immunosuppression, HIV virion assembly and protein folding.\nConcepts: Scirrhous Hepatocellular Carcinoma (Malignant adenomatous neoplasm - category)\tPeptidyl-Prolyl Cis-Trans Isomerase A, human (Isomerase)\tpegol sihematide (Amino Acid, Peptide, or Protein)\tHepatocholangiocellular Carcinoma (Neoplastic Process)\thomarus americanus/lobster d (Homeopathic remedies letter H)", + "output": "Peptidyl-Prolyl Cis-Trans Isomerase A, human (Isomerase)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Quality of Life Neuromuscular Module Version 3 Young Child Parent Report - In the past one month, how much of a problem has this been for your child: It is hard for my child to gain or lose weight when he or she wants to.\nConcepts: SCROTUM PAIN (Pain of skin)\tCMKBR1 (Chemokine Receptor Gene)\tTornjak (Non-Sporting Breed)\tTropine benzohydryl ether (Antimuscarinic drug used in parkinsonism)\tPQL0810 (Intellectual Product)", + "output": "PQL0810 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment: I was exposed to hostile incoming fire.\nConcepts: NPI - Report Smelling Odors Not Smelled by Others (NPI Questionnaire Question)\tParathyroid Carcinoma TNM Finding v8 (Finding)\tDRRI-2 - D: Exposed Hostile Incoming Fire (DRRI-2 Questionnaire Question)\tDental Overjets (Congenital Abnormality)\tRenal medullary carcinoma (Malignant tumor of kidney parenchyma)", + "output": "DRRI-2 - D: Exposed Hostile Incoming Fire (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Professional or Occupational Group described as a person who works in epidemiology.\nConcepts: crotalaria (Fabaceae)\tHAQ0116 (Intellectual Product)\tNon-Human Papillomavirus-Related Penile Intraepithelial Neoplasia (Neoplastic Process)\tbutyryl-CoA catabolism to butanol (1-butanol biosynthetic process)\tEpidemiologist (Health Personnel)", + "output": "Epidemiologist (Health Personnel)" + }, + { + "input": "Definition: something described as to provide support for a transition period between postdoctoral training and an independent research career.\nConcepts: R2TP complex (protein-containing complex)\tHMGIC-RAD51L1 Fusion Protein (Fusion protein)\tpM1 Cutaneous Melanoma v6 (Finding)\tK01 Mechanism (Research Career Programs, K-Series)\tNOPHO AML 2004 (Intellectual Product)", + "output": "K01 Mechanism (Research Career Programs, K-Series)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as a rare genetic disease with characteristics of adult-onset myofibrillar myopathy variably associated with cardiomyopathy and/or posterior pole cataracts. Patients typically present progressive proximal and distal muscle weakness and wasting of lower and upper limbs, often with velopharyngeal involvement including dysphagia, dysphonia and ventilatory insufficiency. Electromyography shows myopathic features and muscle biopsy reveals myofibrillar myopathy changes. Caused by heterozygous mutation in the alpha-B-crystallin gene (CRYAB) on chromosome 11q23.\nConcepts: CDGSH Iron-Sulfur Domain-Containing Protein 2 (Amino Acid, Peptide, or Protein)\tcellular hypotonic salinity response (cellular response to salt stress)\tSamplers, Laboratory, Automated, High Pressure/Temperature (Medical Device)\tAlpha-B crystallin-related late-onset myopathy (Hereditary disorder of musculoskeletal system)\tTSQM Version 1.4 Questionnaire Question (Clinical or Research Assessment Question)", + "output": "Alpha-B crystallin-related late-onset myopathy (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: Systemic artery described as an artery arising from the bifurcation of the abdominal aorta which then bifurcates forming the internal and external iliac arteries.\nConcepts: High-frequency deafness (Diseases of inner ear)\tTEL Gene Mutation (Cell or Molecular Dysfunction)\tGroup 1 photochromogen (Atypical mycobacteria species a-m)\tPOST CARDIOTOMY SYNDROME (Cardiac and vascular procedural complications)\tCommon iliac artery, NOS (Systemic artery)", + "output": "Common iliac artery, NOS (Systemic artery)" + }, + { + "input": "Definition: Organism Function described as the regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana.\nConcepts: Tall Papillae Present (Finding)\tPulmonary blastoma (Neoplastic Process)\tAspergillus Fumigatus Complex (Fungus)\tvascular tissue pattern formation (Organism Function)\tCTAG1B Positive (Positive Laboratory Test Result)", + "output": "vascular tissue pattern formation (Organism Function)" + }, + { + "input": "Definition: valproate described as a kind of epilepsy treatment drug\nConcepts: skin exam (Procedure on skin)\tDIVALPROEX (Fatty acid derivatives, antiepileptics)\tEXPTIME (Finding)\tStandard weaning infant formula (Standard infant formula)\tSnow Sport (Sports)", + "output": "DIVALPROEX (Fatty acid derivatives, antiepileptics)" + }, + { + "input": "Definition: FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Dyspnea Severity: Over the past 7 days, how short of breath did you get with each of these activities?: Walking (faster than your usual speed) for 50 steps without stopping. Please indicate why you did not do this in the past 7 days.\nConcepts: Target Cells (Red Blood Cell Count measurement)\tInstitutional Review Board Independent Ethics Committee Submission (Submission)\tcancer/testis antigen family 4, member 8 (LINC01194 gene)\tFACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Fast 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\tMicrocephalic primordial dwarfism Dauber type (Hereditary disorder of nervous system)", + "output": "FACIT-Dyspnea Scale 33 Item Bank Version - Severity: Walk Fast 50 Steps Why Not (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)" + }, + { + "input": "Definition: Substance-Related Disorders described as a disorder characterized by clinically significant sexual dysfunction (including impaired desire, impaired arousal, impaired orgasm, or sexual pain) that is fully explained by substance use.\nConcepts: Imidoesters (Imides)\tDisorder in childhood, NOS (Mental disorders)\tSubstance-induced sexual dysfunction (Finding)\tFRP-1 protein (Amino Acid Transport System L)\tosmium (Metals, Heavy)", + "output": "Substance-induced sexual dysfunction (Finding)" + }, + { + "input": "Definition: Name described as a non-unique textual identifier for the biologic entity group. EXAMPLE(S): Litter1, X12, Farmer Brown's Cows\nConcepts: ServiceDeliveryLocation.code (Code)\tintermembrane sphingolipid transfer (nitrogen compound transport)\tBiologic Entity Group Name (Intellectual Product)\tWorst Possible Feeling of Well-Being (Intellectual Product)\tintegrity (General adjectival modifier)", + "output": "Biologic Entity Group Name (Intellectual Product)" + }, + { + "input": "Definition: Angiogenesis Inhibitors described as a semi-synthetic, orally bioavailable taxane derivative with potential antineoplastic and antiangiogenic properties. Tesetaxel binds to and stabilizes tubulin, promoting microtubule assembly and thereby preventing microtubule depolymerization. This may lead to cell cycle arrest and an inhibition of cell proliferation. This agent may also inhibit pro-angiogenic factors such as vascular endothelial growth factor (VEGF). As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C37451\" active clinical trials using this agent.\nConcepts: Columbia-Suicide Severity Rating Scale Screening Questionnaire Test Code (CDISC Questionnaire Terminology)\ttesetaxel (Taxanes)\tEctasia of left atrial appendage (Congenital dilatation of atrium)\t6 Mercaptopurine Riboside (Purine antagonist)\tNumber of Pelvic Lymph Nodes Positive for Tumor by H&E (Numbers)", + "output": "tesetaxel (Taxanes)" + }, + { + "input": "Definition: Musculoskeletal Diseases described as a type of incomitant strabismus in which both elevator muscles (i.e., the inferior oblique and superior rectus muscles) of the same eye are weak leading to restricted elevation and hypotropia.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Whole Exome Sequencing, Human (IVD Test Reagent/Kits, Molecular Assay)\tPANSS1-Poor Attention (PANSS Clinical Classification Question)\tEMO1-Disgust Responded as Disgust (ERT Functional Test Question)\tdouble elevator palsy (orbit)\tspecific granule (Secretory Granule)", + "output": "double elevator palsy (orbit)" + }, + { + "input": "Definition: something described as human ATP8A2 wild-type allele is located within 13q12-13 and is approximately 649 kb in length. This allele, which encodes probable phospholipid-transporting ATPase IB protein, plays a role in the binding and hydrolysis of ATP.\nConcepts: DKFZP434B1913 (Gene or Genome)\tLyssaviruses (Virus)\tAcid, Myristic (M [Preparations])\tspirituality (Idea or Concept)\tNitric Oxide Receptor (Amino Acid, Peptide, or Protein)", + "output": "DKFZP434B1913 (Gene or Genome)" + }, + { + "input": "Definition: Allium described as a bulbous herb isolated from the plant Allium sativum with potential antineoplastic activity. Garlic contains a number of different organosulfur compounds, some of which have displayed antineoplastic activity.\nConcepts: Allium sativum (Allergen class)\tPIK3CB Gene Mutation (Cell or Molecular Dysfunction)\tCasitas B-Lineage Lymphoma Proto-Oncogene (Biologically Active Substance)\theptasaccharide transport (Cell Function)\ttitin protein, human (Enzyme)", + "output": "Allium sativum (Allergen class)" + }, + { + "input": "Definition: something described as this gene plays a role in DNA binding and myogenesis.\nConcepts: ARTHRITIS, SUPPURATIVE (Arthritis, Infectious)\tUrine Pellet (Body Substance)\tSquamous Papilloma of Vagina (Vaginal Squamous Neoplasm)\tMYOD (Transcription factor genes)\tTRS (Genetic Function)", + "output": "MYOD (Transcription factor genes)" + }, + { + "input": "Definition: something described as a question about whether an individual has or had problems with their job or education because of their disease or treatment.\nConcepts: Have you had any problems with your job or your education because of your disease or treatment (Intellectual Product)\tAdult Kidney Wilms Tumor (Neoplastic Process)\tConnective tissue massage each 15 minutes (Massage)\tPeak Inspiratory Pressure -- diagnostic test (Pulmonary function tests)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Breast Cancer (Medical Device)", + "output": "Have you had any problems with your job or your education because of your disease or treatment (Intellectual Product)" + }, + { + "input": "Definition: Progesterone Receptor Positive by Immunohistochemistry described as an immunohistochemical staining finding indicating that 21-30 percent of the cells in a tissue sample are expressing progesterone receptor.\nConcepts: regulation of glandular kallikrein-kinin cascade (regulation of kinin cascade)\tmaintenance of postsynaptic specialization structure (maintenance of synapse structure)\tRegistered dietician (Level II (HCPCS/National) Modifiers)\tFreezers, Food, Walk-In (Freezers, Food)\tProgesterone Receptor Positive by Immunohistochemistry 21-30 Percent (Laboratory or Test Result)", + "output": "Progesterone Receptor Positive by Immunohistochemistry 21-30 Percent (Laboratory or Test Result)" + }, + { + "input": "Definition: Disease Qualifier described as having to do with metastasis, which is the spread of cancer from the primary site (place where it started) to other places in the body.\nConcepts: discadenine metabolic process (purine-containing compound metabolic process)\tregulation of abscisic acid formation (regulation of secondary metabolic process)\t(2R)-2-amino-3-mercaptopropanoic acid (C [Preparations])\tMT - metastatic to (Functional Concept)\tSample Study Population (Population Group)", + "output": "MT - metastatic to (Functional Concept)" + }, + { + "input": "Definition: something described as dryness of the eye surfaces caused by deficiency of tears or conjunctival secretions. It may be associated with vitamin A deficiency, trauma, or any condition in which the eyelids do not close completely.\nConcepts: Positron Emission Tomography with Radiolabeled Targeting Agents (Positron-Emission Tomography)\tReused Cardiac Lead (Finding)\tTesticular Artery (Body Part, Organ, or Organ Component)\tXEROPHTHALMIA (Ocular surface finding)\tCognitive Behavior Therapy for Insomnia (Therapeutic or Preventive Procedure)", + "output": "XEROPHTHALMIA (Ocular surface finding)" + }, + { + "input": "Definition: Cell Function described as the process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.\nConcepts: type B pancreatic cell differentiation (Cell Function)\tHow Often Mouth Sores (Clinical or Research Assessment Question)\tDicarboxylic aciduria (LABORATORY ABNORMALITIES)\tGrade 3 Small intestinal anastomotic leak (Small Intestinal Anastomotic Leak, CTCAE)\tFAC005-Trouble Meeting Needs of Family (FACT-B Version 4 Questionnaire Question)", + "output": "type B pancreatic cell differentiation (Cell Function)" + }, + { + "input": "Definition: Abnormal pancreas morphology described as abnormal passage communicating with the PANCREAS.\nConcepts: fistula; pancreas (Pancreatic duct disorder)\tNasal Cream Dose Form (Biomedical or Dental Material)\tStage I Bladder Adenocarcinoma (Stage I Carcinoma of Bladder)\tEndoscopic dilatation NOC (Dilation procedure)\tSacroiliac Supports (Orthoses, Spine, Sacroiliac)", + "output": "fistula; pancreas (Pancreatic duct disorder)" + }, + { + "input": "Definition: Veillonellaceae described as a genus of strictly anaerobic, Gram negative, crescent shaped bacterium assigned to the phylum Firmicutes and the family Veillonellaceae.\nConcepts: SHORT GUT SYNDROME (Sequela of disorder)\tMultiple Endocrine Neoplasia I Gene Mutation (Gene Mutant)\tskin leiomyoma (Benign Dermal Neoplasm)\tIbogaine (methoxyindole)\tSelenomonas species (Bacteroidaceae)", + "output": "Selenomonas species (Bacteroidaceae)" + }, + { + "input": "Definition: something described as human PRRC1 wild-type allele is located in the vicinity of 5q23.2 and is approximately 37 kb in length. This allele, which encodes protein PRRC1, has no known function. Mutation or deletion of the gene may be associated with leukemogenesis.\nConcepts: Behavioral Health & Social Service Providers; Behavior Analyst (Professional or Occupational Group)\tPRRC1 wt Allele (PRRC1 gene)\tMucosal telangiectasiae (Anatomical Abnormality)\tHAQ02-Aid: Special or Built Up Chair (HAQ-DI Without VAS Questionnaire Question)\tsuppressor of cytokine signaling 2 protein, human (Amino Acid, Peptide, or Protein)", + "output": "PRRC1 wt Allele (PRRC1 gene)" + }, + { + "input": "Definition: Lung Diseases, Interstitial described as pulmonary fibrosis is a chronic inflammation and progressive fibrosis of the pulmonary alveolar walls, with steadily progressive dyspnea; granulomatous disorders affecting the lungs are included in this term.\nConcepts: Intravesical use (Body cavity route)\tpulmonary fibrosis/granuloma (Lung Diseases, Interstitial)\tResponse, Unfolded Protein (Post-Translational Protein Processing)\tNeuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase (Enzyme)\tTransition Rule (Rule)", + "output": "pulmonary fibrosis/granuloma (Lung Diseases, Interstitial)" + }, + { + "input": "Definition: Numbers described as the number of corpora lutea present in the ovary/ovaries.\nConcepts: Chondroitin Sulfate Proteoglycan 3 (Hyalectins)\tLINTUZUMAB (Pharmacologic Substance)\tPDPN gene (Genes, Regulator)\tCARCINOMA, CERUMINOUS GLAND, MALIGNANT (Malignant neoplasm with apocrine differentiation)\tCorpora Lutea Number (Numbers)", + "output": "Corpora Lutea Number (Numbers)" + }, + { + "input": "Definition: Immunologic Factor described as an antibody-drug conjugate (ADC) composed of a proprietary monoclonal antibody against a tumor-associated antigen (TAA) linked to an as of yet undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration of tamrintamab pamozirine, the monoclonal antibody moiety of SC-003 targets and binds to the TAA expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills the TAA-expressing cancer cells, through an as of yet unknown mechanism of action.\nConcepts: Anterior Temporal Lobectomy (Neurosurgical Procedures)\tChronic Cutaneous Graft Versus Host Disease (Chronic graft-versus-host disease)\tregulation of MAP kinase cascade involved in axon regeneration (regulation of axon regeneration)\tTAMRINTAMAB PAMOZIRINE (Pharmacologic Substance)\tAbnormal ossification involving the bones of the pelvis (Anatomical Abnormality)", + "output": "TAMRINTAMAB PAMOZIRINE (Pharmacologic Substance)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a regulatory role in limb development and is involved in sonic hedgehog signal transduction.\nConcepts: actin filament debranching (Cell Function)\tFallopian Tube Cancer cM1 TNM Finding v7 (Finding)\tAbnormal neck curve (Finding)\tGLI3 (Gene or Genome)\tAdult echocardiography procedure report (Clinical procedure report)", + "output": "GLI3 (Gene or Genome)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as pro-interleukin-16 (1332 aa, ~142 kDa) is encoded by the human IL16 gene. This protein is involved in both transcriptional repression and cytokine signaling.\nConcepts: Hemoglobin Cast Measurement (Urine Sediment Analysis Measurement)\tL-tyrosine carboxy-lyase (Molecular Function)\tVerbascum thapsus / great mullein / common mullein (Pharmacologic Substance)\tPro-IL-16 (Immunologic Factor)\tUndefined nonspinal adjustment narrative required (Therapeutic or Preventive Procedure)", + "output": "Pro-IL-16 (Immunologic Factor)" + }, + { + "input": "Definition: something described as any elsewhere undefined Oriental herb and natural substance, letter B, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Calcium hydroxyapatite product (phosphate salt)\tMemory functions, unspecified (Elderly)\tltr B undef.Orntl hrb&ntrl (Oriental herbs and natural substances letter B)\tcyclin-dependent kinase inhibitor (Gene or Genome)\tglial cell generation (Organ or Tissue Function)", + "output": "ltr B undef.Orntl hrb&ntrl (Oriental herbs and natural substances letter B)" + }, + { + "input": "Definition: Pacific States described as constituent state of the United States of America; it lies at the extreme northwest of the North American continent and is the largest peninsula in the Western Hemisphere.\nConcepts: Ifex Regimen (Regimen Used to Treat Malignant Peritoneal Neoplasm)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Thyroid, Thyroglobulin Antibody (Medical Device)\thantaviruses (Bunyaviridae)\tAlaska (Region of United States of America)\tLupus Anticoagulant Sensitive APTT Actual/Control (Lupus Anticoagulant Sensitive APTT Measurement)", + "output": "Alaska (Region of United States of America)" + }, + { + "input": "Definition: something described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Did you worry?\nConcepts: SOLUTION (Liquid Dosage Form)\tEORTC QLQ-C30 Version 3 - Did You Worry (EORTC QLQ-C30 Version 3 Questionnaire Question)\tLecithin-cholesterol acyltransferase deficiency (Rare Non-Neoplastic Disorder)\tenvironmental health (Biomedical Occupation or Discipline)\tHomogenate (Specimen)", + "output": "EORTC QLQ-C30 Version 3 - Did You Worry (EORTC QLQ-C30 Version 3 Questionnaire Question)" + }, + { + "input": "Definition: something described as dispensing a non-prescription nutraceutical product. Use in conjunction with the appropriate ADX code. Service is billed as a no-charge item.\nConcepts: Colonoscopic polypectomy (Endoscopic polypectomy of large intestine)\tNicotine Vapings (Inhalation of substance)\tEthiopian (Population Group)\ttoxic myopathy (Disorder of skeletal muscle)\tSample non-prescription nutraceutical product dispensing no charge (Health Care Activity)", + "output": "Sample non-prescription nutraceutical product dispensing no charge (Health Care Activity)" + }, + { + "input": "Definition: Cell Component described as a heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.\nConcepts: ERBB4:ERBB2 complex location (Cell Component)\tPeriod, Preoperative (Temporal Concept)\tPremature thelarche (Finding)\tPolynesia (Geographic Area)\tregulation of GABA-A receptor activity (regulation of signaling receptor activity)", + "output": "ERBB4:ERBB2 complex location (Cell Component)" + }, + { + "input": "Definition: positive regulation of response to DNA damage checkpoint signaling described as any process that activates or increases the frequency, rate or extent of response to G1 DNA damage checkpoint signaling.\nConcepts: topotecan HCl (Topoisomerase Inhibitors)\t20: 1823425-1868537 (Chromosome 20 Physical Location)\trectal tube@@MISCELL@EACH (Medical Devices)\tup-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint (Cell Function)\tOAB-q Short Form Questionnaire Question (Clinical or Research Assessment Question)", + "output": "up-regulation of response to signal involved in mitotic cell cycle G1/S transition DNA damage checkpoint (Cell Function)" + }, + { + "input": "Definition: Salmonella described as any bacterial organism that can be assigned to the genus Salmonella and serotype group B.\nConcepts: Left eye structure (EYES AND EYE APPENDAGES)\tBUTANOL 001 (B [Preparations])\tLARYNGEAL NEOPLASIA (Respiratory Tract Neoplasms)\tCongenital tufting enteropathy (Disease or Syndrome)\tSalmonella Serotype Group B (Salmonella)", + "output": "Salmonella Serotype Group B (Salmonella)" + }, + { + "input": "Definition: steroid hormone receptor binding described as interacting selectively and non-covalently with a mineralocorticoid receptor.\nConcepts: Microbiology Specimen Examination Original Result (Quantitative Concept)\tmineralocorticoid receptor binding (nuclear receptor binding)\tPercent Eosinophils (Percent)\tNONCONDUCTED P WAVE PHYSIOLOGY NOT DEFINED (Finding)\tINFRANATANT, SERUM (Body Substance)", + "output": "mineralocorticoid receptor binding (nuclear receptor binding)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test names of questionnaire questions associated with the Pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Teen (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: behavioral response to ether (adult behavior)\tDasheens (Plant)\tEndocardium of anterior wall of left ventricle (Body Location or Region)\tPediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report Questionnaire Test Name (Intellectual Product)\tirradiation of hemibody (Other megavoltage radiation treatment)", + "output": "Pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report Questionnaire Test Name (Intellectual Product)" + }, + { + "input": "Definition: cellular anatomical entity described as the second outermost layer of the spore wall, as described in Saccharomyces.\nConcepts: regulation of toluene degradation (regulation of cellular catabolic process)\tchitosan layer of spore wall (cellular anatomical entity)\tValve, Bicuspid Aortic (Congenital heart disease)\tIMPEDANCE PLETHYSMOGR TRANSTHORACIC (Plethysmography, Impedance)\tregulation of immunoglobulin mediated immune response (regulation of B cell mediated immunity)", + "output": "chitosan layer of spore wall (cellular anatomical entity)" + }, + { + "input": "Definition: Coriandreae described as a plant genus of the family APIACEAE. The leaves are the source of cilantro and the seeds are the source of coriander, both of which are used in SPICES.\nConcepts: gstroint.tube rmvl ea.rmvl (Substance administration management)\tSupernumerary phantom limb (Phantom Limb Syndrome)\tCoriandrum L., 1753 (Plant)\tTotal Volume (Property)\tKDPI Clinical Classification Question (Clinical or Research Assessment Question)", + "output": "Coriandrum L., 1753 (Plant)" + }, + { + "input": "Definition: Nucleic Acid Biochemistry described as the branch of biochemistry that is specifically concerned with the structure, synthesis, and maintenance of RNA.\nConcepts: RNA Biochemistry (Biomedical Occupation or Discipline)\tLRMSC Grade 4, Subcutaneous Tissue (Disease Grade Qualifier)\tHSP75 (Gene or Genome)\tTin Polyphosphates (Polyphosphates)\tDelta Like Canonical Notch Ligand 3 Gene Positive (DLL3 Positive)", + "output": "RNA Biochemistry (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Organic Chemical described as a drug that is used to prevent and treat osteoporosis, and is being studied in the treatment of cancer that has spread to the bones. It belongs to the family of drugs called bisphosphonates.\nConcepts: IVD Test Reagent/Kits, Serology, Bacteria, Rickettsia rickettsii, Antibody (Medical Device)\tProduct containing ibandronate sodium (Organic Chemical)\tStage I Laryngeal Throat Cancer (Laryngeal Cancer by AJCC v8 Stage)\tAGEN-1884 (Amino Acid, Peptide, or Protein)\tper milliliter (Unit of Dose Calculation)", + "output": "Product containing ibandronate sodium (Organic Chemical)" + }, + { + "input": "Definition: Cytidine Diphosphate described as the ester of diacylglycerol with the terminal phosphate of cytidine diphosphate. It serves as an intermediate in the biosynthesis of phosphatidylethanolamine and phosphatidylserine in bacteria.\nConcepts: Performances, Athletic (Individual Behavior)\ttRNA methyltransferase activity (catalytic activity, acting on a tRNA)\tSustained Supraventricular Tachycardia by ECG Finding (Finding)\tPostsurgical Stage II (Intellectual Product)\tCytidine Diphosphodiacylglycerols (Nucleoside Diphosphate Sugars)", + "output": "Cytidine Diphosphodiacylglycerols (Nucleoside Diphosphate Sugars)" + }, + { + "input": "Definition: Polysaccharides described as family of glycoproteins with repeating disaccharide subunits, including the mucopolysaccharide glycoproteins (mucoproteins), and found in extracellular matrix.\nConcepts: proteoglycans (Proteins)\tFACT/GOG-NTX Version 4 - Enjoy Things I Usually Do for Fun (FACT/GOG-NTX Version 4 Questionnaire Question)\tGyrus parietalis medialis (Body Part, Organ, or Organ Component)\tsignal transduction involved in cell cycle checkpoint (intracellular signal transduction)\tCarpinus virginiana (Ostrya)", + "output": "proteoglycans (Proteins)" + }, + { + "input": "Definition: something described as diabetes Distress Scale for Parents of Teens with Type 1 Diabetes - During the past month, I have been: Frustrated because my teen ignores my suggestions about diabetes.\nConcepts: CTCAE Grade 4 Hemolysis (Hemolysis, CTCAE)\tcell-matrix adhesion involved in ameboidal cell migration (Cell Function)\tSymmetric mesomelic limb shortness (Short extremities)\tAG270 (Pharmacologic Substance)\tDDS0214 (Intellectual Product)", + "output": "DDS0214 (Intellectual Product)" + }, + { + "input": "Definition: Oligosaccharides described as oligosaccharide containing two monosaccharide units linked by a glycosidic bond.\nConcepts: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine (protein-DNA covalent cross-linking via peptidyl-tyrosine)\tDCL - Diffuse cutaneous leishmaniasis (Disease or Syndrome)\tmental disorder pharmacotherapy (Chemotherapy)\tdisaccharides (Carbohydrates)\tsecretory iga (Immunologic Factor)", + "output": "disaccharides (Carbohydrates)" + }, + { + "input": "Definition: Intellectual Product described as trauma Symptom Checklist for Children - Going away in my mind, trying not to think.\nConcepts: TSCC01-Going Away in My Mind (Intellectual Product)\tPandemic (Phenomenon or Process)\tExcision Repair Cross-Complementing 1 (Enzyme)\tmental deficiency-spasticity-congenital ichthyosis syndrome (Disorder of skin AND/OR subcutaneous tissue of head)\tBoston Terrier (Non-Sporting Breed)", + "output": "TSCC01-Going Away in My Mind (Intellectual Product)" + }, + { + "input": "Definition: something described as disintegrin and metalloproteinase domain-containing protein 11 (769 aa, ~83 kDa) is encoded by the human ADAM11 gene. This protein plays a role in integrin-mediated signaling.\nConcepts: Concomitant Medication Reason Not Collected (Idea or Concept)\t6 Lead NEHB-SPORI (Spatial Concept)\tErg oncogene protein, human (Biologically Active Substance)\taicardi's syndrome (Degenerative disorder of eye)\tDisintegrin and Metalloproteinase Domain-Containing Protein 11 (Amino Acid, Peptide, or Protein)", + "output": "Disintegrin and Metalloproteinase Domain-Containing Protein 11 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: cellular lipid metabolic process described as the chemical reactions and pathways involving glycerolipids, any lipid with a glycerol backbone. Diacylglycerol and phosphatidate are key lipid intermediates of glycerolipid biosynthesis.\nConcepts: Grade 1 Dry eye (Finding)\tViruses, H5N2 (Virus)\tglycerolipid metabolic process (Molecular Function)\tDensity Functional Theories (Intellectual Product)\tsulfonylurea receptor binding (Molecular Function)", + "output": "glycerolipid metabolic process (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as reagents used to resist changes in the concentration of substances during analyses performed to determine blood coagulation, usually keeping the pH of the solution as constant as possible.\nConcepts: Intravaginal (Intra-location)\tComplement Bb Measurement (Laboratory Procedure)\tINTER-ALPHA TRYPSIN INHIBITOR, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tCAP 57 (Gene or Genome)\tIVD Test Reagent/Kits, Hematology, Buffer, Coagulation (Medical Device)", + "output": "IVD Test Reagent/Kits, Hematology, Buffer, Coagulation (Medical Device)" + }, + { + "input": "Definition: Anaemias due to disorders of glutathione metabolism described as a condition associated with glucose-6-phosphate dehydrogenase deficiency, which is characterized by hemolysis.\nConcepts: Rigid bronchoscope (Medical Device)\tLocation of Chest Pain (ACC-AHA Measure)\tFavism (Disease or Syndrome)\tLatin American (Population Group)\tSpecify Therapeutic Agent (Form Directive)", + "output": "Favism (Disease or Syndrome)" + }, + { + "input": "Definition: Functional Concept described as the sequences, mRNA transcripts, protein products, or other genome encoded molecules of the cell.\nConcepts: up regulation of protein secretion (Cell Function)\tDistorted red blood cells resembling keratocytes (Finding)\tGenomic Entity (Miscellaneous Molecular Biology Terms)\tInstitutional National Research Service Award (Governmental or Regulatory Activity)\tNarrow incisura width (Abnormal incisura morphology)", + "output": "Genomic Entity (Miscellaneous Molecular Biology Terms)" + }, + { + "input": "Definition: Intellectual Product described as the Oswestry Disability Index Version 2.1a (ODI v2.1a) Section 6: Standing.\nConcepts: Cardiopulmonary Resuscitation Compression Feedback Devices (Anesthesia/Respiratory Equipment and Supplies)\tODI01-Standing (ODI v2.1a Questionnaire Question)\tMerremia Dennst. ex Endl., 1841 (Plant)\tOut-of Pocket Expenditures (Insurance and Payment Issues)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Influenza A, Avian Subtype, RNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Influenza A, RNA)", + "output": "ODI01-Standing (ODI v2.1a Questionnaire Question)" + }, + { + "input": "Definition: Homeopathic remedies letter P described as pellitory-of-the-wall.\nConcepts: EC 3.4.21.- (Amino Acid, Peptide, or Protein)\tATC (Neoplastic Syndromes, Hereditary)\tNephrotic syndrome with lesion of lobular glomerulonephritis (Disease or Syndrome)\tparietaria officinalis/pelli (Pharmacologic Substance)\tMacroblepharon, ectropion, hypertelorism, macrostomia syndrome (Orbital separation excessive)", + "output": "parietaria officinalis/pelli (Pharmacologic Substance)" + }, + { + "input": "Definition: Fungus described as a genus of mold fungi in the family Trichosphaeriaceae. Species within this genus are typically found growing on live or dead grasses in tropical, subtropical, and temperate regions, are rarely found growing indoors, and rarely pose a health hazard to humans.\nConcepts: Nigrospora, NOS (Trichosphaeriaceae)\tDISULFOTON (Acetylcholinesterase Inhibitors)\ttryptophan 5-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen)\tCentral Nervous System Angiolipoma (Neoplastic Process)\ttaxoid 7beta-hydroxylase activity (Molecular Function)", + "output": "Nigrospora, NOS (Trichosphaeriaceae)" + }, + { + "input": "Definition: something described as uridine analogs; 18F-labeled compound.\nConcepts: malignant neoplasm of sebaceous glands (Neoplastic Process)\tTris (Organic Chemical)\tCOXPD2 - combined oxidative phosphorylation defect type 2 (Mitochondrial cytopathy)\t5-fluorouridine (halocarbon compound)\tArabis L. (Brassicaceae)", + "output": "5-fluorouridine (halocarbon compound)" + }, + { + "input": "Definition: something described as a PCR technique that uses the SPF10 primer set for HPV detection. It amplifies a 65 bp region from the L1 region of the HPV genome. Genotype identification is achieved by using a reverse line probe assay (LiPA).\nConcepts: Ectodermal Dysplasia Gene Panel Reagents (Medical Device)\tpositive regulation of antigen processing and presentation of peptide antigen via MHC class Ib (positive regulation of antigen processing and presentation of peptide antigen)\tSPF10-LiPA PCR Assay (Line Probe Assay)\tFACT-C Version 4 - I Have Accepted My Illness (Intellectual Product)\tHealth Facility Administrators (Professional or Occupational Group)", + "output": "SPF10-LiPA PCR Assay (Line Probe Assay)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a therapeutic peptide vaccine containing the human telomerase reverse transcriptase catalytic subunit (hTERT)-derived universal cancer peptides 2 (UCP2) and 4 (UCP4), and combined with the immunoadjuvant Montanide ISA 51 VG, with potential immunostimulating and antineoplastic activities. Vaccination with the CD4-specific telomerase peptide vaccine UCPVax activates the immune system to mount a T-helper 1 (TH1) CD4-positive T-lymphocyte immune response against and ultimately killing telomerase-expressing cells. Telomerase, a reverse transcriptase normally repressed in healthy cells, is overexpressed in most cancer cells and plays a key role in cellular proliferation.\nConcepts: uterus large (Uterus size)\tCD4-specific Telomerase Peptide Vaccine UCPVax (Immunologic Factor)\tcellular response to tropane (response to tropane)\tTRAPEZOID BONE (Bone structure of carpus)\tI have cramps in my stomach area (Intellectual Product)", + "output": "CD4-specific Telomerase Peptide Vaccine UCPVax (Immunologic Factor)" + }, + { + "input": "Definition: Iberian Peninsula described as a country in Southwestern Europe, bordering the North Atlantic Ocean, west of Spain.\nConcepts: brainstem precerebellar neuron precursor migration (Cell Function)\tPT (Country)\tcellular creatinine homeostasis (creatinine homeostasis)\tspinal anesthesia (neurological procedures)\tIVD Panels, Human Genetics, Bone Marrow Syndrome, Dyskeratosis Congenita (IVD Panels, Human Genetics, Bone Marrow Syndrome)", + "output": "PT (Country)" + }, + { + "input": "Definition: Oropharyngeal Neoplasms described as a benign or malignant neoplasm involving the lip.\nConcepts: trichoblast fate specification (Cell Function)\tlips neoplasm (Neoplasm by anatomical site)\tTumor of Scrotum (oncologic disorders)\tsymbiotic interaction (host organism interaction)\tUndefined homeopathic remedy letter N narrative required (Pharmacologic Substance)", + "output": "lips neoplasm (Neoplasm by anatomical site)" + }, + { + "input": "Definition: Sequence Number described as an identifier that describes the relative position of food and water consumption data within a series.\nConcepts: Cardiac Study Computed Tomography Software (Software, Computed Tomography Study)\tGalline Experimental Organism Diagnosis (Experimental Organism Neoplasm by Organism)\tregulation of sulfate assimilation (Molecular Function)\tFood and Water Consumption Sequence Number (Intellectual Product)\tRecorders, Graphic, Cardiography (Medical Device)", + "output": "Food and Water Consumption Sequence Number (Intellectual Product)" + }, + { + "input": "Definition: something described as documentation of agreement to the protocol amendment by the investigator and sponsor, including signatures.\nConcepts: Amendment Signature Page (Document type)\tAntigen, 27E10 (Neural Cell Adhesion Molecules)\tBarretts esophagus with high grade dysplasia (Barretts esophagus with dysplasia)\tMUSCLE TENSION HEADACHE (Migraine and Headache Syndromes)\tNine-Hole Peg Test Functional Test Test Name (Intellectual Product)", + "output": "Amendment Signature Page (Document type)" + }, + { + "input": "Definition: Nonmembranous cytoplasmic organelle described as cell center; the centrosphere together with a pair of centrioles surrounded by a cloud of amorphous material called the pericentriolar region.\nConcepts: cell migration involved in coronary angiogenesis (Cell Function)\tlymph gland crystal cell differentiation (crystal cell differentiation)\tFacial Cleft (Abnormality of the face)\tcentrosome (Cardinal cell part)\tANTISERA, FLUORESCENT, POLIOVIRUS 1-3 (Immunologic Factor)", + "output": "centrosome (Cardinal cell part)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of esophagus and esophagogastric junction cancer, following the rules of the TNM AJCC v7 classification system as they pertain to staging of regional lymph nodes.\nConcepts: Uniform Resource Identifier (Universal ID type)\tTRANSFERRIN, RHODAMINE, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tEsophagus and Esophagogastric Junction Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Esophagus and Esophagogastric Junction Cancer Pathologic TNM Finding v7)\tRBM15 (RNA-Binding Proteins)\tWD4-Miss Work Half Day or More (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)", + "output": "Esophagus and Esophagogastric Junction Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Esophagus and Esophagogastric Junction Cancer Pathologic TNM Finding v7)" + }, + { + "input": "Definition: Unit of Dose Calculation described as a unit of concentration equal to liter per day divided by milligram per kilogram.\nConcepts: Small Cell Carcinoma, Esophagus (Digestive System Small Cell Carcinoma)\tNon-Neoplastic Respiratory Disorder (Non-Neoplastic Disorder by Site)\tBalantidiums (Ciliophora)\tGrade 3 Biliary anastomotic leak (Biliary Anastomotic Leak, CTCAE)\tLiter per Day per Milligram per Kilogram (Quantitative Concept)", + "output": "Liter per Day per Milligram per Kilogram (Quantitative Concept)" + }, + { + "input": "Definition: Diagnostic Procedure described as the use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.\nConcepts: GS 4104 (Organic Chemical)\textracellular signal regulated kinase 8 (Gene or Genome)\t1p36.12 (Chromosome band)\tNomas (Acute necrotizing stomatitis)\tDiffusion Tensor MRIs (Diagnostic Procedure)", + "output": "Diffusion Tensor MRIs (Diagnostic Procedure)" + }, + { + "input": "Definition: PODCI Adolescent Self-Reported Version Questionnaire Question described as pediatric Outcomes Data Collection Instrument, Adolescent Self-Reported Version (PODCI Adolescent Self-Reported Version) How often do you use assistive devices (such as braces, crutches, or wheelchair) for sitting and standing?\nConcepts: PODCI Adolescent Self-Reported Version - Use Assistive Devices for Sitting (PODCI Adolescent Self-Reported Version Questionnaire Question)\tSerum bilirubin total (Bilirubin, total measurement)\trectal gyrus (Body Part, Organ, or Organ Component)\tKeratoconjunctivitis (Conjunctivitis)\tDD3 LICHENS (Protista)", + "output": "PODCI Adolescent Self-Reported Version - Use Assistive Devices for Sitting (PODCI Adolescent Self-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: parent described as for animals consider ANIMAL PARENTAL BEHAVIOR.\nConcepts: Child Development: 1 Month (Infant milestone)\tfather (parent)\tFollicular Thyroid Cancer (ADENOMAS AND ADENOCARCINOMAS)\tDatabase Management Documentation (Document type)\tCongenital shortened small intestine (Abnormality of the small intestine)", + "output": "father (parent)" + }, + { + "input": "Definition: Metastatic Thyroid Gland Medullary Carcinoma described as thyroid gland medullary carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes.\nConcepts: Nuclear Matrix Protein 22 Measurement (Laboratory Procedure)\tTiv Language (Language)\tLocally Advanced Thyroid Gland Medullary Carcinoma (Neoplastic Process)\tYes, No, or Not Applicable Response (Clinical or Research Assessment Answer)\tGrade 4 Alcohol intolerance (Alcohol Intolerance, CTCAE)", + "output": "Locally Advanced Thyroid Gland Medullary Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Organic Chemical described as the hydrochloride salt form of abexinostat, an orally bioavailable hydroxamate-based pan-inhibitor of histone deacetylase (HDAC), with potential antineoplastic and radiosensitizing activities. Upon administration, abexinostat inhibits HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, abexinostat decreases the expression of the DNA-repair protein RAD51, thereby reducing the RAD51 protein, preventing repair of DNA double-strand breaks and increasing sensitivity of tumor cells to DNA damaging agents. HDAC, upregulated in many tumor types, is an enzyme that is responsible for the deacetylation of chromatin histone proteins.\nConcepts: RGS22 wt Allele (RGS22 gene)\tStage I Nasal Cavity and Paranasal Sinus Cancer (Paranasal sinus and nasal cavity neoplasms malignant and unspecified)\tFatty Acid Transport Proteins (Biologically Active Substance)\tAbexinostat Hydrochloride (Organic Chemical)\tParaspinal Region (Body Location or Region)", + "output": "Abexinostat Hydrochloride (Organic Chemical)" + }, + { + "input": "Definition: something described as sterile powder and sterile solvent intended for the preparation of a solution for injection/infusion by dissolving the powder in the solvent.\nConcepts: Powder and solvent for solution for injection/infusion (Combined Dosage Form)\tGrade 1 Chest wall pain (Finding)\tcataract; coralliform (CATARACT, MARNER TYPE)\tNF-kappa B1/p65 complex (Cell Component)\tARF (Kidney Failure)", + "output": "Powder and solvent for solution for injection/infusion (Combined Dosage Form)" + }, + { + "input": "Definition: something described as zhi zi\nConcepts: Gardeniae / zhi zi (Oriental herbs and natural substances letter G)\tAllopathic & Osteopathic Physicians; Internal Medicine, Critical Care Medicine (Professional or Occupational Group)\tbegelomab (Selective immunosuppressants)\tsuperior temporal gyrus (Body Part, Organ, or Organ Component)\tUHDR1-Perseverative Thinking: Frequency (UHDRS 1999 Version Clinical Classification Question)", + "output": "Gardeniae / zhi zi (Oriental herbs and natural substances letter G)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as nuclear receptor coactivator 2 (1464 aa, ~159 kDa) is encoded by the human NCOA2 gene. This protein plays a role in the regulation of steroid-mediated gene transcription.\nConcepts: pain in leg (Central Nervous System)\trnrx diarrhea care (Elimination Management)\tMonitor/Controllers, Oxygen (Medical Device)\tsignal transduction involved in mitotic cell cycle spindle orientation checkpoint (Cell Function)\tbHLHe75 (Amino Acid, Peptide, or Protein)", + "output": "bHLHe75 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as an assessment of the disease response to therapy within the involved spleen.\nConcepts: Product containing vancomycin (Glycopeptide antibacterials)\tStandardized Name of Procedure (Intellectual Product)\treceptor anabolism (Molecular Function)\tCompound 133314 (Pharmacologic Substance)\tSpleen Response (Disease Response)", + "output": "Spleen Response (Disease Response)" + }, + { + "input": "Definition: Student Characteristics & Academic Environment described as ability in nonlanguage areas such as spatial relations, mathematics, or music.\nConcepts: NEUREXIN IV, DROSOPHILA, HOMOLOG OF (Receptor Gene)\tNonverbal Ability (Ability)\tI've been pretty successful in life (Clinical or Research Assessment Question)\tRas Peptide PR54 (Amino Acid, Peptide, or Protein)\tBMP signaling pathway involved in mesodermal cell fate specification (BMP Receptor Signaling Pathway)", + "output": "Nonverbal Ability (Ability)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as amphoterin-induced protein 2 (522 aa, ~58 kDa) is encoded by the human AMIGO2 gene. This protein plays a role in both the negative regulation of apoptosis and the mediation of cell-cell adhesion.\nConcepts: UDPglucose:N-acetyl-D-glucosaminyldiphosphoundecaprenol 4-beta-D-glucosyltransferase activity (Molecular Function)\tmethylthiohexylmalate isomerase activity (Molecular Function)\tElevated CSF gamma-hydroxybutyric acid (Finding)\tThenylidene-Lignan-P (Topoisomerase Inhibitor [EPC])\tAmphoterin-Induced Protein 2 (Cell Adhesion Molecules)", + "output": "Amphoterin-Induced Protein 2 (Cell Adhesion Molecules)" + }, + { + "input": "Definition: Sex Chromosomes described as a sex chromosome that has been inactivated.\nConcepts: down-regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination (Cell Function)\tinactive sex chromosome (Sex Chromosomes)\tStage I Cervical Carcinoma FIGO 2018 (Neoplastic Process)\tDextrans (Organic Chemical)\tcoenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity (oxidoreductase activity, acting on the CH-NH group of donors)", + "output": "inactive sex chromosome (Sex Chromosomes)" + }, + { + "input": "Definition: Education, Professional described as advanced programs of training to meet certain professional requirements in fields other than medicine or dentistry, e.g., pharmacology, nutrition, nursing, etc.\nConcepts: Nonmedical Internship (Education, Professional)\tribosome-inactivating protein CY503 (Amino Acid, Peptide, or Protein)\tRight Lung Alveolus (Alveolus)\tAirway Clearance Units, High-Frequency Chest Wall Oscillation, Cuirass (Medical Device)\tKITLG (Hematopoietic Cell Growth Factors)", + "output": "Nonmedical Internship (Education, Professional)" + }, + { + "input": "Definition: Body organ structure described as a fibrous tissue that connects bone, muscle, and other soft body parts\nConcepts: Phalen's maneuver or Reverse Phalen's maneuver (Physical Examination)\tFascia cluster (General anatomical term)\tNPS Questionnaire Question (Clinical or Research Assessment Question)\tTULOC (Location)\tostomy irrigator (Medical Device)", + "output": "Fascia cluster (General anatomical term)" + }, + { + "input": "Definition: Antibodies described as any immunoglobulin that recognizes Tn antigen, which is comprised of N-acetylgalactosamine (GalNAc) bound to serine or threonine protein residues by O-linked glycosylation.\nConcepts: Transmembrane Protease, Serine 1 Gene (HPN gene)\tAnti-Tn Antigen Antibody (Amino Acid, Peptide, or Protein)\tJapanese Encephalitis, unspecified formulation (Viral Vaccines)\tRadioimmunoassays (Chemical procedure)\tActivity tolerance (Finding)", + "output": "Anti-Tn Antigen Antibody (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Finding described as conjunctival melanoma with no distant metastasis.\nConcepts: Conjunctival Melanoma cM0 TNM Finding v8 (Finding)\tWebbed 1st-3rd toes (Syndactyly of the toes)\tGeotrichum penicillatum (Geotrichum)\tcellular response to alcohol (cellular response to oxygen-containing compound)\tUHDRS 1999 Version - Since Last Assessment Feel (Intellectual Product)", + "output": "Conjunctival Melanoma cM0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as blood flow from lacunar networks that establishes the maternal-placental circulation approximately at the end of the third week of gestation.\nConcepts: Triangular end part of the middle bone of the middle finger (Triangular epiphyses of the 3rd finger)\tLaboratory oven (Laboratory instruments and equipment)\tPrimordial Uteroplacental Circulation (Embryonic Structure)\tbulbus arteriosus development (Organ or Tissue Function)\thindgut development (Organ or Tissue Function)", + "output": "Primordial Uteroplacental Circulation (Embryonic Structure)" + }, + { + "input": "Definition: something described as any biological process involved in the maintenance of an internal steady state of urea.\nConcepts: trachyspermum ammi (Oils, Volatile)\tInjectables (Pharmacologic Substance)\tGrade 1 Watering eyes (Watering Eyes, CTCAE)\turea homeostasis (chemical homeostasis)\tLaryngeal Carcinoma pN2b TNM Finding v8 (Laryngeal Cancer pN2 TNM Finding v8)", + "output": "urea homeostasis (chemical homeostasis)" + }, + { + "input": "Definition: something described as one of two small conical nodules of elastic cartilage which caps the apex of the arytenoid cartilages.\nConcepts: Preference for Making Decisions about Health Care (Intellectual Product)\tTumor Identifier Location (Spatial Concept)\tStructure of corniculate cartilage (Structure of half of neck lateral to midsagittal plane)\tChoroid Plexus Epithelium of the Lateral Ventricle (Subdivision of epithelium of choroid plexus)\tRegulation of Cell Shape (Cell Function)", + "output": "Structure of corniculate cartilage (Structure of half of neck lateral to midsagittal plane)" + }, + { + "input": "Definition: Finding described as hypopharyngeal cancer with moderately advanced local disease. Tumor invades thyroid/cricoid cartilage, hyoid bone, thyroid gland, or central compartment soft tissue. Central compartment soft tissue includes prelaryngeal strap muscles and subcutaneous fat.\nConcepts: Knife/Scalpel Handles, Microsurgery (Medical Device)\tIncreased circulating IgG subclass (Finding)\tactivin complex (Cell Component)\tHypopharyngeal Carcinoma pT4a TNM Finding v8 (Hypopharyngeal Cancer pT4 TNM Finding v8)\tadipose tissue myelolipoma (Adrenal Gland Diseases)", + "output": "Hypopharyngeal Carcinoma pT4a TNM Finding v8 (Hypopharyngeal Cancer pT4 TNM Finding v8)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's distress related to their physical problems with feeling swollen.\nConcepts: Manufacturing Deficiency (Device Evaluation Conclusion)\tFormaldehyde product (Anti-Infective Agents)\tenterobactin breakdown (siderophore catabolic process)\tBALLER-GEROLD SYNDROME (Dysplasia of limb)\tDistress over Physical Problem with Feeling Swollen (Findings-Based Question)", + "output": "Distress over Physical Problem with Feeling Swollen (Findings-Based Question)" + }, + { + "input": "Definition: Obstetrics closure described as a surgical procedure performed to prevent a miscarriage by stitching the opening of the cervix closed.\nConcepts: HBGCHTHB (Hemoglobin measurement)\tCervical os suture (Cervix therapeutic procedures)\tGrade 1 Skin infection (Finding)\tiron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide (peptidyl-glutamic acid modification)\tAVL01120 (ADNI-AVLT Questionnaire Question)", + "output": "Cervical os suture (Cervix therapeutic procedures)" + }, + { + "input": "Definition: Hemangioma described as a hemangioma, a benign tumor of the vascular endothelial cells, located in the airway, typically below the vocal chords, that can cause severe obstruction of the airway.\nConcepts: Angioma of the Subglottis (Larynx)\tAdult premature aging syndrome (DNA Repair-Deficiency)\tvacuole (Cytoplasmic Vesicles)\todor of breath fetor oris (Halitosis)\tmalpractice (Qualitative Concept)", + "output": "Angioma of the Subglottis (Larynx)" + }, + { + "input": "Definition: signal transduction involved in mitotic DNA damage checkpoint described as a signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.\nConcepts: Chinese Herbal Formulation PHY906 (Pharmacologic Substance)\tsignal transduction involved in mitotic G1 DNA damage checkpoint (signal transduction involved in mitotic DNA damage checkpoint)\tPseudoprogeria syndrome (Hereditary disorder of nervous system)\tchemotherapeutics growth-signaling inhibitors erdafitinib (Pharmacologic Substance)\tcytoplasmic tRNA transport into mitochondrion (tRNA transport)", + "output": "signal transduction involved in mitotic G1 DNA damage checkpoint (signal transduction involved in mitotic DNA damage checkpoint)" + }, + { + "input": "Definition: Cell Component described as a protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p.\nConcepts: autologous lymphoma cell lysate-pulsed autologous dendritic cell vaccine (Pharmacologic Substance)\ttRNA (m2G10) methyltransferase complex location (tRNA methyltransferase complex)\tBrucella canis Carmichael and Bruner 1968 (Brucella)\tproteasome (prosome, macropain) subunit, beta type, 10 (Peptidase Gene)\tEye of the tiger anomaly of globus pallidus (Finding)", + "output": "tRNA (m2G10) methyltransferase complex location (tRNA methyltransferase complex)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk and Resilience Inventory-2 (DRRI-2) During deployment, the people I worked with: touched me in a sexual way against my will.\nConcepts: {Kit} (Potency Unit)\tautologous IKDC (Cell)\tRadiolabeled Antibodies (Immunologic Factor)\tDRRI1K15 (Intellectual Product)\tReligious Missions (Religion)", + "output": "DRRI1K15 (Intellectual Product)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of a set of bone-like structures in the mouth used for biting and chewing.\nConcepts: Dentes (Organ with organ cavity)\tProduct Pre-1938 Indicator (Pre-1938 Indicator)\tCephalometric soft tissue plane (Body Location or Region)\tcomedones closed (Pathologic Function)\tMaxillary Sinus Cancer pT4a TNM Finding v7 (Finding)", + "output": "Dentes (Organ with organ cavity)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 2-hydroxy-7-hydroxymethylchromene-2-carboxylate = 2-hydroxy-4-hydroxymethylbenzalpyruvate.\nConcepts: Y-Piece Connector Device (Manufactured Object)\tProtein, Organized by Origin (Biologically Active Substance)\t2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity (Molecular Function)\tVOLPK (Volume)\tInterphalangeal Joint 5 of the Foot (Interphalangeal Joint 5)", + "output": "2-hydroxy-7-hydroxymethylchromene-2-carboxylate isomerase activity (Molecular Function)" + }, + { + "input": "Definition: Cell Function described as the specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.\nConcepts: cellular response to high light intensity (Cell Function)\tFracture of Spine Related to Birth (Finding)\testablishment of ommatidial planar polarity (Cell Function)\tWord Recognition: Word [12] (ADAS-Cog CDISC Version Questionnaire Question)\tSet of nuclei of lateral lemniscus (Set of neuraxis structures)", + "output": "establishment of ommatidial planar polarity (Cell Function)" + }, + { + "input": "Definition: something described as a standardized rating scale originally developed by Lewis-Jones and Finlay in 1995. This instrument is used to make quality of life assessment in children with skin conditions.\nConcepts: CDLQ1 (Clinical or Research Assessment Questionnaire)\tFAC018-Bothered by Treatment Side Effect (Intellectual Product)\tLubrication Problem Identified (Device Evaluation Result)\tIncreased insoluble fiber diet (High residue diet)\tResource Description Framework (Format)", + "output": "CDLQ1 (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: something described as the reemergence of skin squamous cell carcinoma after a period of remission, at or adjacent to the site of the original tumor.\nConcepts: Nigella sativa, homeopathic preparation (Pharmacologic Substance)\tLocally Recurrent Skin Squamous Cell Carcinoma (Neoplastic Process)\tUNASSIGNED (Dosage Forms)\tTbpB Transferrin Binding Protein (Receptor)\tDermoids of cornea (Limbal dermoid)", + "output": "Locally Recurrent Skin Squamous Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as an erythrocytic glucose-6-phosphate dehydrogenase assay is a device used to measure the activity of the enzyme glucose-6-phosphate dehydrogenase or of glucose-6-phosphate dehydrogenase isoenzymes. The results of this assay are used in the diagnosis and treatment of nonspherocytic congenital hemolytic anemia or drug-induced hemolytic anemia associated with a glucose-6-phosphate dehydrogenase deficiency. This generic device includes assays based on fluorescence, electrophoresis, methemoglobin reduction, catalase inhibition, and ultraviolet kinetics.\nConcepts: Regulator of G Protein Signaling 7 (Biologically Active Substance)\tBad Protein (Apoptosis Regulatory Proteins)\thusky voice (Signs and Symptoms, Respiratory)\tGLUCOSE-6-PHOSPHATE DEHYDROGENASE (ERYTHROCYTIC), U.V. KINETIC (Medical Device)\tAllopathic & Osteopathic Physicians; Preventive Medicine, Sports Medicine (Professional or Occupational Group)", + "output": "GLUCOSE-6-PHOSPHATE DEHYDROGENASE (ERYTHROCYTIC), U.V. KINETIC (Medical Device)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with any part of a U2 small nuclear ribonucleoprotein particle.\nConcepts: U2 snRNP binding (snRNP binding)\tCompressor Air Pump (pump)\t19: 52874031-52898291 (Chromosome 19 Physical Location)\tsingle-stranded DNA endodeoxyribonuclease activator activity (enzyme activator activity)\tAphasic status epilepticus (Focal non-convulsive status epilepticus without coma)", + "output": "U2 snRNP binding (snRNP binding)" + }, + { + "input": "Definition: regulation of immunoglobulin production described as any process that activates or increases the frequency, rate, or extent of immunoglobulin production.\nConcepts: extensor plantar responses (Plantar reflex)\tSlackia exigua (Bacterium)\tup-regulation of immunoglobulin production (Cell Function)\tnorleucine transaminase activity (Molecular Function)\tintravenous administration (intravenous administration)", + "output": "up-regulation of immunoglobulin production (Cell Function)" + }, + { + "input": "Definition: Limb-girdle muscle atrophy described as atrophy of the muscles of the pelvic girdle (also known as hip girdle), i.e., the gluteal muscles, the lateral rotators, the adductors, the psoas major and the iliacus muscle.\nConcepts: Oxygen Candles (Medical Device)\tPelvic girdle amyotrophy (Limb-girdle muscle atrophy)\tShields, Splash (Medical Device)\tregulation of establishment of Sertoli cell barrier (regulation of cell development)\tPolyglycolic acid suture (Sutures, Synthetic, Absorbable)", + "output": "Pelvic girdle amyotrophy (Limb-girdle muscle atrophy)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in neutrophil differentiation and is involved in inflammatory processes.\nConcepts: osteoblast proliferation (Cell Function)\tIntrahepatic Bile Duct Cancer Pathologic Regional Lymph Nodes TNM Finding v7 (Intrahepatic Bile Duct Cancer Pathologic TNM Finding v7)\tregulation of brassinosteroid biosynthetic process (regulation of steroid hormone biosynthetic process)\tcationic antimicrobial protein 37 (Gene or Genome)\tupregulation of connective tissue replacement (positive regulation of tissue remodeling)", + "output": "cationic antimicrobial protein 37 (Gene or Genome)" + }, + { + "input": "Definition: PURINES, PYRIMIDINES AND NUCLEIC ACIDS described as high molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.\nConcepts: tumor necrosis factor receptor superfamily, member 18 protein, human (Tumor Necrosis Factor Receptor)\tNucleic Acid (Organic Chemicals)\tData Collection (Research Activity)\tManaged Care Organizations; Point of Service (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tMale Contraceptive Agents (Pharmacologic Substance)", + "output": "Nucleic Acid (Organic Chemicals)" + }, + { + "input": "Definition: Stage II Contiguous Adult Indolent Non-Hodgkin Lymphoma described as stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ).\nConcepts: PAXIP1 gene (Gene or Genome)\tpositive regulation of protein transport from nucleus to cytoplasm (positive regulation of intracellular protein transport)\tregulation of phospholipid translocation (regulation of cellular component organization)\tSUMATRIPTAN (Vasoconstrictor Agents)\tContiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma (Stage II Contiguous Adult Indolent Non-Hodgkin Lymphoma)", + "output": "Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma (Stage II Contiguous Adult Indolent Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Disease or Syndrome described as a disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.\nConcepts: Phage phi X 174 (Microvirus)\tBrain Ischemia-Hypoxias (Brain Hypoxia)\tAPCH1TN (CDISC Clinical Classification Terminology)\tubiquitin-protein ligase activity involved in positive regulation of mitotic metaphase/anaphase transition (ubiquitin-protein transferase activity)\tSyndactyly, cutaneous (Syndactyly)", + "output": "Brain Ischemia-Hypoxias (Brain Hypoxia)" + }, + { + "input": "Definition: something described as organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi.\nConcepts: Slides, Microscope (Manufactured Object)\tregulation of canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation (regulation of embryonic development)\textracellular organelle (Cell Component)\tLiver infections (Classification)\tAnimal, Wild (Animals)", + "output": "extracellular organelle (Cell Component)" + }, + { + "input": "Definition: Ophthalmic Route of Drug Administration described as an ophthalmic route that begins within the cornea.\nConcepts: Intracorneal (Spatial Concept)\tBendiocarb (Pesticides)\tClostridium botulinum (Clostridium species a-f)\tSTAT inhibitor OPB-111077 (Pharmacologic Substance)\tWave Velocity, Pulse (Cardiovascular examination)", + "output": "Intracorneal (Spatial Concept)" + }, + { + "input": "Definition: Hamartoma of skin described as a benign, pigmented skin growth caused by an overgrowth of the epidermis. It is typically seen at birth, but can develop in early childhood or later in life. Most cases are sporadic, but familial patterns of inheritance have been observed.\nConcepts: Neoplasm of lymph node (Neoplastic Process)\tepidermal naevus (Non-neoplastic nevus of skin)\ttranscription protein-DNA-RNA complex disassembly (Cell Function)\tJoint movement: passive (Mobility as a finding)\tPrimary T-Cell Lymphoma of Breast (T-Cell Lymphoma)", + "output": "epidermal naevus (Non-neoplastic nevus of skin)" + }, + { + "input": "Definition: Body System described as the portion of the salivary system that conveys the saliva produced in the acinar salivary gland system to the oral cavity. The duct salivary gland system includes the ductus parotideus, ductus submandibularis, ductus sublingualis major, and ductus sublinguales minores, as well as the ducts from the minor salivary glands.\nConcepts: SCHISTOSOMA JAPONICUM (Schistosomatidae)\tstress oxidative (Cell or Molecular Dysfunction)\tFetal iodine syndrome (congenital malformation syndromes due to known exogenous causes)\tDuct Salivary Gland System (Salivary Gland Tissue)\tapocynum andros/spreading do (Pharmacologic Substance)", + "output": "Duct Salivary Gland System (Salivary Gland Tissue)" + }, + { + "input": "Definition: something described as a rare soft tissue tumor of uncertain lineage characterized by the presence of neoplastic spindle to round cells forming cords in a fibromyxoid stroma. The lesions are associated with the formation of metaplastic bone. Most patients present with painless subcutaneous masses. Recurrences have been reported in a minority of patients.\nConcepts: Acellular anatomical structure (Cell Component)\tDecreased galactosylation of N-linked protein glycosylation (Finding)\tOssifying Fibromyxoid Tumor (Myxomatous neoplasm)\tI am unable to walk (Clinical or Research Assessment Answer)\tNeuropsychiatric Inventory Questionnaire Test Name (Intellectual Product)", + "output": "Ossifying Fibromyxoid Tumor (Myxomatous neoplasm)" + }, + { + "input": "Definition: Cancer TNM Vessel Invasion Finding Category described as lymphovascular invasion is present or identified.\nConcepts: PerformedSubstanceAdministration.flowRate (Flow Rate)\tARA-C/CDDP/DM (Therapeutic or Preventive Procedure)\tLVI 1 (Finding)\tClear Cell Adenocarcinoma of the Kidney (Malignant neoplasm of kidney)\tdorsalis tabes (Neurosyphilis, Symptomatic)", + "output": "LVI 1 (Finding)" + }, + { + "input": "Definition: Cell Component described as the minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition.\nConcepts: regulation of protein heterodimerization activity (Organism Function)\tType II Hair Cells (Labyrinth)\tVaccines, Cancer (Pharmacologic Substance)\ttelomerase catalytic core complex location (DNA polymerase complex)\tTUBE, TRACHEOSTOMY (Medical Device)", + "output": "telomerase catalytic core complex location (DNA polymerase complex)" + }, + { + "input": "Definition: something described as a score indicating that a patient has 2 risk factors associated with follicular lymphoma and is considered in the intermediate risk group.\nConcepts: dysgerminoma (Neoplastic Process)\tNo Evidence of Metastatic Disease (Finding)\tintracellular receptor-mediated signaling pathway (Signal Transduction)\tB lymphocyte affinity maturation (peripheral B cell selection)\tFLIPI Score 2, Intermediate Risk (Follicular Lymphoma International Prognostic Index)", + "output": "FLIPI Score 2, Intermediate Risk (Follicular Lymphoma International Prognostic Index)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of two or more phases of which at least one is dispersed in the liquid phase, intended for administration by injection.\nConcepts: Refusals, Anesthesia (Individual Behavior)\tAdjuvant Post-operative Targeted Molecular Therapy Was Administered (CPTAC Responses)\tGatifloxacinum (Antibiotic)\tAllogeneic BK-CTLs (Pharmacologic Substance)\tDispersion for Injection Dosage Form (Biomedical or Dental Material)", + "output": "Dispersion for Injection Dosage Form (Biomedical or Dental Material)" + }, + { + "input": "Definition: Pharmacologic Substance described as soft rush.\nConcepts: MLL-PTD (KMT2A Gene Rearrangement)\tAdvanced Technology Center (Organization)\tjuncus effusus/soft rush (Homeopathic remedies letter J)\tFever, Mud (Disease or Syndrome)\tRAD140 (Organic Chemical)", + "output": "juncus effusus/soft rush (Homeopathic remedies letter J)" + }, + { + "input": "Definition: something described as a plant genus of the family ANACARDIACEAE that is the source of anacarcin forte. The nut milk extract is cytotoxic.\nConcepts: Serotonin acetylase (Acetyltransferase)\tWilms Tumor (Neoplastic Process)\tBeta Error (error)\tPupillary block (Anterior chamber structural change, deposit and degeneration)\tSemecarpus (Plant)", + "output": "Semecarpus (Plant)" + }, + { + "input": "Definition: Carrier Proteins described as proteins which bind calcium ions; can act as transport proteins, regulator proteins, or activator proteins.\nConcepts: Gene, Reiterated (Genes)\tCalcium-Binding Protein (Carrier Proteins)\tLittle Urinary Frequency or Urgency; Does not Interfere with Sleep or Other Activities (Finding)\tUnilateral Microphthalmos (Microphthalmos)\tLoss of Chromosome 12 (Chromosomal Loss)", + "output": "Calcium-Binding Protein (Carrier Proteins)" + }, + { + "input": "Definition: something described as this syndrome is characterized by bilateral moderate-to-severe sensorineural hearing loss and salivary gland insensitivity to aldosterone resulting in hyponatremia. It has been described in two brothers. Transmission appeared to be autosomal recessive.\nConcepts: syntax (grammar)\tfamilial polyposis coli (Hereditary Diseases)\tEducational Objectives (Student Characteristics & Academic Environment)\tAlzheimer's Therapeutic Area User Guide v1.0 (CDISC Therapeutic Area User Guide Name and Version)\tHearing loss and salivary gland insensitivity to aldosterone syndrome (Auditory system hereditary disorder)", + "output": "Hearing loss and salivary gland insensitivity to aldosterone syndrome (Auditory system hereditary disorder)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione.\nConcepts: chemical synaptic transmission (anterograde trans-synaptic signaling)\tDetapac (Acetates)\tpyrimidodiazepine:glutathione-disulfide oxidoreductase (oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor)\tFamily Coronaviridae (Enveloped ssRNA virus without a DNA step in life-cycle)\tUSDA (Professional Organization or Group)", + "output": "pyrimidodiazepine:glutathione-disulfide oxidoreductase (oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor)" + }, + { + "input": "Definition: Powder for reconstitution for drug product described as solid preparation consisting of one or more powders, including freeze-dried powders, intended to be dissolved in the specified liquid to obtain a cutaneous solution.\nConcepts: TRSTAT (Completion Status)\tsmooth muscle contraction involved in micturition (urinary bladder smooth muscle contraction)\t8-hydroxyquercetin 8-O-methyltransferase activity (Molecular Function)\tPowder for Topical Solution Dosage Form (Cutaneous AND/OR transdermal dosage form)\tAMLODIPINE MALEATE (Dihydropyridine derivative calcium channel blocker)", + "output": "Powder for Topical Solution Dosage Form (Cutaneous AND/OR transdermal dosage form)" + }, + { + "input": "Definition: Anti-Anxiety Agents described as a carbamate derivate with hypnotic, anti-anxiety, sedative, anticonvulsant and some indirect muscle relaxant properties. Although the exact mechanism of meprobamate is largely unknown, it appears to act as a depressant at multiple sites in the central nervous system, mostly likely through the GABAergic neurotransmitter system, including the thalamus and limbic system.\nConcepts: Pulmonary Static Compliance (Finding)\t1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate (Carbamate anxiolytics)\tRoseoloviruses (Cytomegalovirus)\tAfamelanotide (Peptide hormone-containing product)\tFAC070 (Clinical or Research Assessment Questionnaire)", + "output": "1,3-Propanediol, 2-methyl-2-propyl-, dicarbamate (Carbamate anxiolytics)" + }, + { + "input": "Definition: something described as an insertion of the amino acid sequence proline-histidine-valine between the proline at position 772 and the valine at position 774 of the epidermal growth factor receptor protein.\nConcepts: NP 005219.2:p.P772 V774insPHV (EGFR Protein Variant)\tregulation of cell cycle arrest (Cell Function)\t(5Z)-(15S)-11alpha-hydroxy-9,15-dioxoprostanoate:NAD(P)+ delta13-oxidoreductase activity (Molecular Function)\tIdiopathic Primary Ventricular Tachycardia/Ventricular Flutter by ECG Finding (Ventricular Tachycardia by ECG Finding)\tSpeckled calcifications in the end part of the big toe bone (Anatomical Abnormality)", + "output": "NP 005219.2:p.P772 V774insPHV (EGFR Protein Variant)" + }, + { + "input": "Definition: RAND-36 Questionnaire Question described as RAND 36-Item Health Survey 1.0 - How much of the time during the past 4 weeks: Have you felt downhearted and blue?\nConcepts: Extremitas posterior (Splen)(Lien) (Spleen part)\tExtra cranial suture (Abnormality of cranial sutures)\tRECEPT CATECHOLAMINES (Neurotransmitter Receptor)\tR3601-Have Felt Downhearted and Blue (RAND-36 Questionnaire Question)\t11: 44073675-44223556 (Spatial Concept)", + "output": "R3601-Have Felt Downhearted and Blue (RAND-36 Questionnaire Question)" + }, + { + "input": "Definition: Administration procedure described as administration of a pharmaceutical product by one of a variety of non-specific methods. To be used only where a more-specific term does not apply.\nConcepts: Human anti-mouse antibody (Antibodies)\tNanogels (Nanocomposites)\tAdministration (Health Care Activity)\tAbnormal Phenolsulfonphthalein Test Result (Kidney Function Tests)\tD-Glyceric aciduria (Disorder of glycerate metabolism)", + "output": "Administration (Health Care Activity)" + }, + { + "input": "Definition: something described as stage II includes: T3a, N0, M0. T3a: Tumor more than 20 mm in greatest dimension. Or, any tumor that invades adjacent ocular or orbital structures. Or, any T with perineural tumor invasion. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: Oral herbal material (Biomedical or Dental Material)\tUjoveridin (Diagnostic agents)\tadult diffuse mixed cell lymphoma, metastatic (Ann Arbor Stage IV Aggressive Adult Non-Hodgkin Lymphoma)\tStage II Eyelid Carcinoma AJCC v7 (Eyelid Carcinoma by AJCC v7 Stage)\tHammertoe Syndrome (Anatomical Abnormality)", + "output": "Stage II Eyelid Carcinoma AJCC v7 (Eyelid Carcinoma by AJCC v7 Stage)" + }, + { + "input": "Definition: Dermatologic disorders described as skin diseases involving the HANDS.\nConcepts: Dermatosis, Hand (Dermatologic disorders)\tHMPA (Biologically Active Substance)\tRespiration alteration (Ventilation or Perfusion Signs and Symptoms)\tDNA Probe (DNA)\tresponse generalization (Learning Generalization)", + "output": "Dermatosis, Hand (Dermatologic disorders)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter A described as jiu bai\nConcepts: Structure of oesophageal lymph node (Lymph Node by Anatomic Site)\tCDC HIV CLASSIFICATION FOR ADULTS AND ADOLESCENTS (Intellectual Product)\tIndemnity (Intellectual Product)\tallium macrostemona/jiu bai (Oriental herbs and natural substances letter A)\tDietician, Registered - Nutrition, Pediatric (Professional or Occupational Group)", + "output": "allium macrostemona/jiu bai (Oriental herbs and natural substances letter A)" + }, + { + "input": "Definition: Disease Stage Qualifier described as a stage defined according to St. Jude Children's Research Hospital staging system for childhood non-Hodgkin lymphoma.\nConcepts: nitrite reductase complex location [NAD(P)H] (Cell Component)\tIL-7R-Alpha Gene Mutation (Gene Mutant)\tNegative Number (Number Type)\tDiazomethane (Hydrocarbons)\tSt. Jude Stage (Classification)", + "output": "St. Jude Stage (Classification)" + }, + { + "input": "Definition: Systemic Chemotherapy Course Label described as the sixth chemotherapy course planned.\nConcepts: Immunotherapy Was Not Administered as an Additional Treatment for a New Tumor Event (Finding)\tInferior segment of hair follicle (Region of hair follicle)\tneoxanthin degradation (ether catabolic process)\tarteriography (Other diagnostic radiology and related techniques)\tChemotherapy Course 6 (Therapeutic or Preventive Procedure)", + "output": "Chemotherapy Course 6 (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Common nursing interventions described as actions performed to flush out a urinary catheter\nConcepts: urinary cath irrigation (Care of urinary catheter)\tRecurrent Malignant Endocrine Neoplasm (Malignant neoplasm of endocrine gland)\tUndiagnosed Disease (Disease Attributes)\tS Phase Kinase Associated Protein (Carrier Proteins)\tBRCA2 Syndrome (Hereditary Breast and Ovarian Cancer Syndrome)", + "output": "urinary cath irrigation (Care of urinary catheter)" + }, + { + "input": "Definition: Finding described as synovial biopsy, foreign body synovitis: In patients with silicone joint prostheses, a reactive synovitis in response to silicone particles may develop. This synovitis is seen more frequently with wrist implants than with MCP implants, perhaps due to the greater compressive loading of the wrist. Plant matter can also set up a reactive synovitis.\nConcepts: Abnormality of the superior cerebellar peduncle (Anatomical Abnormality)\tAbnormal proportion of CD19+CD38+IgM+ cells (Abnormal B cell subset distribution)\tGrasp Reflex (Observation of reflex)\tFAC04216 (Intellectual Product)\tSynovial biopsy: foreign body synovitis (Finding)", + "output": "Synovial biopsy: foreign body synovitis (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's ability to move from wheelchair to bed and back.\nConcepts: Psychosocial Support Systems (Social support)\tMoving from wheelchair to bed and return (Clinical or Research Assessment Question)\tT3 (Hormones)\tTurnera (Passifloraceae)\tCONTACT WITH TUBERCULOSIS SOURCE (Personal Attribute)", + "output": "Moving from wheelchair to bed and return (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as drug therapy aimed at forcing cancer cells to resume the process of maturation and therefore to induce tumor to a more differentiated, less aggressive state. Differentiation therapy restrains cancer cells growth and facilitates the application of more conventional therapies.\nConcepts: Kruppel-like factor 1 (Gene or Genome)\tCulture Tubes (Medical Device)\tdifferentiation therapy (Therapeutic or Preventive Procedure)\tBouin's Fluid (Indicator, Reagent, or Diagnostic Aid)\tAnimal Care Committees (Animal Welfare)", + "output": "differentiation therapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: ALDH1A2 gene described as human ALDH1A2 wild-type allele is located in the vicinity of 15q22.1 and is approximately 113 kb in length. This allele, which encodes retinal dehydrogenase 2 protein, is involved in the biosynthesis of retinoic acid, a hormonal signaling molecule.\nConcepts: retinal coloboma (Retinal defect)\tDefined Expression Variable Relationship Local Variable Name (Local Variable Name)\tRALDH-2 (ALDH1A2 gene)\tromidepsin (Enzyme Inhibitors)\tmulti-species biofilm formation on inanimate substrate (multi-species submerged biofilm formation)", + "output": "RALDH-2 (ALDH1A2 gene)" + }, + { + "input": "Definition: something described as the process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types.\nConcepts: Smith Machines (Strength exerciser)\tmonosaccharide anabolism (Molecular Function)\tsamp ntra dspnsg nc (Health Care Activity)\tPQL03-Take Long Time to Eat (Intellectual Product)\tpheromone-induced unidirectional conjugation (Cell Function)", + "output": "pheromone-induced unidirectional conjugation (Cell Function)" + }, + { + "input": "Definition: Population Group described as subgroups of AIDS patients.\nConcepts: AIDS Population (Population Group)\t15 (Natural Number)\tCyclooxygenase-2 (Amino Acid, Peptide, or Protein)\tStudy of magnetics (Physics)\tCalcium Channel Inhibition (Cell Function)", + "output": "AIDS Population (Population Group)" + }, + { + "input": "Definition: Intellectual Product described as quality Of Life Enjoyment And Satisfaction Questionnaire - During the past week how often have you: Made social plans with friends or relatives for future activities?\nConcepts: morocco (Country)\tMasaoka Stage IVa (Neoplastic Process)\tanammoxosome (Cell Component)\tQ-LES-Q - Made Social Plans With Friends (Intellectual Product)\tIntraductal Breast Papillomatosis (Breast Papillomatosis)", + "output": "Q-LES-Q - Made Social Plans With Friends (Intellectual Product)" + }, + { + "input": "Definition: small RNA loading onto RISC described as the transfer of a microRNA (miRNA) strand from a miRNA:miRNA duplex onto the RNA-initiated silencing complex (RISC).\nConcepts: microRNA loading onto RISC involved in gene silencing by microRNA (small RNA loading onto RISC)\tBrain Dead (Comatose)\tVulvar hemangioma (Hemangioma)\tTubulin, Alpha 3c wt Allele (TUBA3C gene)\tMGC20887 (KEAP1 gene)", + "output": "microRNA loading onto RISC involved in gene silencing by microRNA (small RNA loading onto RISC)" + }, + { + "input": "Definition: something described as a genus of obligately aerobic, Gram negative, rod shaped bacterium in the phylum Bacteroidetes and the family Flavobacteriaceae.\nConcepts: core of the nucleus accumbens (Body Part, Organ, or Organ Component)\tFACIT-F Version 4 - Limit Social Activity, I am Tired (Intellectual Product)\tskein-like inclusion (Inclusion Bodies)\tELIZABETHKINGIA (Flavobacteriaceae)\tresponse to pullulan (Cell Function)", + "output": "ELIZABETHKINGIA (Flavobacteriaceae)" + }, + { + "input": "Definition: something described as a protein complex that inhibits multiple events of replication initiation during one replication cycle.\nConcepts: replication inhibiting complex location (protein-containing complex)\tEPIC113D (EPIC-26 Questionnaire Question)\tAnn Arbor Stage IV B Lymphoblastic Lymphoma (Neoplastic Process)\tVaman ea.h (Medicine, Ayurvedic)\tADL0318B (Intellectual Product)", + "output": "replication inhibiting complex location (protein-containing complex)" + }, + { + "input": "Definition: Abnormal waist to hip ratio described as decreased waist-to-hip ratio (WHR) is a measurement below the average for the dimensionless ratio of the circumference of the waist to that of the hips. WHR is calculated as waist measurement divided by hip measurement.\nConcepts: Linolenic Acid (Plant derived omega 3 fatty acid)\tDecreased waist to hip ratio (Abnormal waist to hip ratio)\tPerformed Substance Administration Product Dose Description (Product Dose Description)\tmin.mol/l/g (Quantitative Concept)\tBTIC vaccine (Immunologic Factor)", + "output": "Decreased waist to hip ratio (Abnormal waist to hip ratio)" + }, + { + "input": "Definition: Skin graft material described as a graft of small pieces or strips placed apart from each other on the wound or defect.\nConcepts: Strip graft of skin (Biomedical or Dental Material)\tHK/SING Zebrafish (Fish)\tMinute Times Millimole per Milliliter (Measurement Unit Description)\tCytochrome C Oxidase Deficiency (Inborn Errors of Metabolism)\tbranched-chain-2-oxoacid decarboxylase activity (Molecular Function)", + "output": "Strip graft of skin (Biomedical or Dental Material)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cell-surface proteins that bind epinephrine and/or norepinephrine with high affinity and trigger intracellular changes. The two major classes of adrenergic receptors, alpha and beta, were originally discriminated based on their cellular actions but now are distinguished by their relative affinity for characteristic synthetic ligands. Adrenergic receptors may also be classified according to the subtypes of G-proteins with which they bind; this scheme does not respect the alpha-beta distinction.\nConcepts: Malignant mixed tumor of lacrimal gland (carcinoma of lacrimal gland)\tacute inflammatory response to non-antigenic stimulus (acute inflammatory response)\tadrenergic receptors (Neurotransmitter Receptor)\tRehabilitation, Cardiovascular (Tissue Perfusion Management)\tMortality rate (Community health status)", + "output": "adrenergic receptors (Neurotransmitter Receptor)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify mutations in the collagen, type IV, alpha 5 (COL4A5) gene, located at chromosome Xq22, which encodes for the alpha 5 (IV) chain of type IV collagen that makes up a large portion of basement membranes. Mutations at this locus have been identified in patients with diseases that include Alport's syndrome and hereditary nephritis.\nConcepts: Ventricular extrasystoles with syncope, perodactyly and Robin sequence syndrome (Multiple malformation syndrome with facial-limb defects as major feature)\tassessments dietary (Diagnostic Procedure)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL4A5 (Medical Device)\talpha-D-glucose-1-phosphate phosphohydrolase activity (Molecular Function)\tpomegranate seed oil (Organic Chemical)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL4A5 (Medical Device)" + }, + { + "input": "Definition: Prostheses and Implants described as a small device used to correct a heartbeat that is abnormal (too fast, too slow, or irregular). The device is placed by surgery in the chest or abdomen. Wires are passed through a vein to connect the device to the heart. When it detects abnormal heartbeats, it sends an electrical shock to the heart to restore the heartbeat to normal.\nConcepts: Basophil Band Form Count (White Blood Cell Count procedure)\tImplantable Cardioverter Defibrillator (Electrodes, Implanted)\tTesticular Cancer pN3 TNM Finding v7 (Testicular Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tThroat Tightening (Symptoms)\tLEIOMYOMA, MESOVARIAL, MALIGNANT (Neoplastic Process)", + "output": "Implantable Cardioverter Defibrillator (Electrodes, Implanted)" + }, + { + "input": "Definition: Cytokine Receptor Binding described as interacting selectively and non-covalently with the interleukin-23 receptor.\nConcepts: FAC06102 (Intellectual Product)\tsalutaridine reductase (NADPH) activity (Molecular Function)\tENAVATUZUMAB (Amino Acid, Peptide, or Protein)\tinterleukin-23 receptor binding activity (Molecular Function)\tTotal Plasma Cells (White blood cell analyses)", + "output": "interleukin-23 receptor binding activity (Molecular Function)" + }, + { + "input": "Definition: Malignant melanoma of ciliary body described as a ciliary body melanoma characterized by the presence of malignant large epithelioid melanocytes.\nConcepts: Rectal SSP (Neoplastic Process)\tWW Domain Containing Adaptor With Coiled-Coil (Regulatory Protein)\tCorrosion Casting (Replica Techniques)\tMucopolysaccharidosis Type IIIB (Connective Tissue Diseases)\tEpithelioid Cell Melanoma of the Ciliary Body (Neoplastic Process)", + "output": "Epithelioid Cell Melanoma of the Ciliary Body (Neoplastic Process)" + }, + { + "input": "Definition: Immunoglobulin Class Switching described as the switching of activated B cells from IgM biosynthesis to biosynthesis of an IgA isotype, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and one of the IgA constant region gene segments in the immunoglobulin heavy chain locus.\nConcepts: Random Allocation (Clinical Trials Design)\tisotype switching to IgA isotypes (Immunoglobulin Class Switching)\tFailures, Academic (Personal failure)\tHelleborus orientalis, Homeopathic preparation (Homeopathic remedies letter H)\tMeasured Tumor Identification (Diagnostic Procedure)", + "output": "isotype switching to IgA isotypes (Immunoglobulin Class Switching)" + }, + { + "input": "Definition: Parenteral Route of Drug Administration described as administration within the tubules of an organ.\nConcepts: Robbery, Grave (History of Medicine)\tIMETELSTAT SODIUM (Antisense Oligonucleotides)\tPortacaval (Spatial Concept)\tCompletely dentate teeth condition severely compromised with 4 or more in all sextants (Finding of condition of completely dentate teeth)\tINTRATUBULAR (Parenteral Route of Drug Administration)", + "output": "INTRATUBULAR (Parenteral Route of Drug Administration)" + }, + { + "input": "Definition: Disease of diaphragm described as a rare syndrome inherited in an autosomal recessive pattern. It is characterized by the presence of diaphragmatic defects, distinctive facial features (hypertelorism, low-set ears, flat nasal bridge, and micrognathia), distal digital hypoplasia, lung hypoplasia, and brain, gastrointestinal, and cardiovascular malformations.\nConcepts: down-regulation of generation of L-type calcium current (Cell Function)\tSWISS-PROT (Information Resources)\tnegative regulation of phosphate metabolic process (Cell Function)\tFryns Syndrome (Disease or Syndrome)\tGRANULIN (Protein or Enzyme Type Measurement)", + "output": "Fryns Syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as the non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other.\nConcepts: Schedules and Appointments (Organization and Administration)\tPreretinal hemorrhage [dup] (Fundus hemorrhage)\tPHOSPHOLIPASES A 02 GROUP IV (phospholipase A2-alpha)\tFinancial Pressure (Mental Process)\tcell-cell adhesion involved in galactose-specific flocculation (Molecular Function)", + "output": "cell-cell adhesion involved in galactose-specific flocculation (Molecular Function)" + }, + { + "input": "Definition: Biologically Active Substance described as stable prostaglandin formed from PGH2 or PGE2; stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction in some vessels.\nConcepts: Product containing F series prostaglandin (Prostaglandins)\tMissing Identifier Reason Code (Intellectual Product)\tCDS1 Gene Mutation (Gene mutations and other alterations NEC)\tBroccoli Sprout/Broccoli Seed Extract Supplement (Antioxidants)\tColectomy total (Colectomy)", + "output": "Product containing F series prostaglandin (Prostaglandins)" + }, + { + "input": "Definition: something described as expected function of a member of the nursing profession.\nConcepts: Inferior Internal Articular Artery (Branch of popliteal artery)\t10: 47127013-47233044 (Spatial Concept)\tPQL03-Get Sick Easily (PedsQL Neuromuscular Module Version 3.0 Teen Report Questionnaire Question)\tnurse's role (Attitude of Health Personnel)\tCusp Restricted Motion Severity (Cardiovascular finding)", + "output": "nurse's role (Attitude of Health Personnel)" + }, + { + "input": "Definition: Mechanically assisted spontaneous ventilation described as a ventilatory mode delivering CONTINUOUS POSITIVE AIRWAY PRESSURE with a time cycled change between an upper and lower airway pressure level, allowing unrestricted spontaneous breathing throughout the ventilatory cycle.\nConcepts: PQL18-Hard to Use Bathroom (Intellectual Product)\tregulation of macroautophagy (Cell Function)\tCraniosacral Flexion (Organism Function)\tMalignant - descriptor (Behavior descriptors)\tVentilation Mode, APRV (Therapeutic or Preventive Procedure)", + "output": "Ventilation Mode, APRV (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Hypocalcemia Severity described as a mental state in which one is not thinking clearly.\nConcepts: Suboptimal Debulking (Therapeutic or Preventive Procedure)\tANTISERA, FLUORESCENT, HERPESVIRUS HOMINIS 1,2 (Indicator, Reagent, or Diagnostic Aid)\tCD19-Targeted EGFRt/19-28z/4-1BBL \"Armored\" CAR Modified T Cells (therapeutic autologous lymphocytes)\tdaze (Metabolic Acidosis Severity)\tNEPHROCALCINOSIS (Abnormal renal morphology)", + "output": "daze (Metabolic Acidosis Severity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as basal segmental artery, each instance of which supplies the basal segments of the lower lobe of some right lung.\nConcepts: ADR (General clinical state)\tSulfur Mustard Compound (Mustard Agent)\tLymphoid Blood-Forming Cells (Bone marrow stem cell)\tDRRI1N01 (DRRI-2 Questionnaire Question)\tRight basal segmental artery (Basal segmental artery)", + "output": "Right basal segmental artery (Basal segmental artery)" + }, + { + "input": "Definition: Arthropathy described as painful inflammation of the bursa. It most often affects the hips, shoulders, and elbows.\nConcepts: Lateral Filing Cabinets (Manufactured Object)\tAnalyzers, Physiologic, Neuromuscular Function, Functional Age (Medical Device)\tSF36 v1.0 Standard - Question 4b (SF36 v1.0 Standard Questionnaire Question)\tregulation of D-amino-acid oxidase activity (regulation of oxidoreductase activity)\tBURSITIS (Arthritis)", + "output": "BURSITIS (Arthritis)" + }, + { + "input": "Definition: something described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory, MCI Version - Check all that were used: toaster oven.\nConcepts: ADL03-Appliance: Toaster Oven (ADCS-ADL MCI Questionnaire Question)\tStage I Carcinoma of the Ureter (Stage I Renal Pelvis and Ureter Cancer AJCC v7)\tNasolacrimal sac lymphoma (Neoplastic Process)\tEPIC1-Problem Weak Urine Stream/Emptying (EPIC-26 Questionnaire Question)\tphosphinothricin synthesis (phosphinothricin metabolic process)", + "output": "ADL03-Appliance: Toaster Oven (ADCS-ADL MCI Questionnaire Question)" + }, + { + "input": "Definition: cellular diagnosis, melanoma described as a melanoma of the skin characterized by single cell infiltration of the papillary dermis by atypical melanocytes, in a background of lentigo maligna changes.\nConcepts: ABIN2-NFKB1-TPL-1 complex location (protein-containing complex)\tMalignant Lentigo Melanoma (Malignant melanoma - category)\tBurning Waste Smoke Exposure (Finding)\t1-alpha,25-dihydroxyvitamin D3 23-hydroxylase activity (vitamin D 23-hydroxylase activity)\tDEVICE, DETECTION, SULFIDE (Medical Device)", + "output": "Malignant Lentigo Melanoma (Malignant melanoma - category)" + }, + { + "input": "Definition: Balneology described as treatment by application of hot sand.\nConcepts: h*pg/mL/(mg/kg/day) (Quantitative Concept)\tANCHOR, FASCIAL (Medical Device)\tS,S-dimethyl-beta-propiothetin catabolic process (organic substance catabolic process)\tammotherapy (Therapeutic or Preventive Procedure)\tTF2F1 (Gene or Genome)", + "output": "ammotherapy (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in genes associated with nephrogenic diabetes insipidus, a form of diabetes characterized by a defect in the kidneys that leads to excessive urine production. Genetic variants at multiple loci have been associated with nephrogenic diabetes insipidus. These reagents are intended to detect mutations in multiple nephrogenic diabetes insipidus-associated loci simultaneously.\nConcepts: L-ornithine ammonia-lyase (Molecular Function)\tMicroscopes, Inverted Stage (Laboratory microscope)\ttranslocation; balanced (Congenital chromosomal disease)\tIVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Nephrogenic Diabetes Insipidus, Mutation (Medical Device)\tProvince (Geographic Locations)", + "output": "IVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Nephrogenic Diabetes Insipidus, Mutation (Medical Device)" + }, + { + "input": "Definition: Drug allergens described as a class Ia antiarrhythmic drug that is structurally-related to PROCAINE.\nConcepts: Crystallization Purification (Purifying)\tFundulus (Fish)\tAmide, Procaine (Class Ia antiarrhythmic agent)\tPODCI112 (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tendogenous opioids (Opiates)", + "output": "Amide, Procaine (Class Ia antiarrhythmic agent)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins.\nConcepts: recycling endosome to Golgi transport (Golgi vesicle transport)\tNephritides, Lupus (Glomerular disease due to systemic lupus erythematosus)\tArchaeal Chromosomes (Chromosomes)\tWands, Smoke Evacuation, Surgical Laser Handpiece (Wands, Smoke Evacuation)\tselenocysteine synthesis (selenocysteine metabolic process)", + "output": "selenocysteine synthesis (selenocysteine metabolic process)" + }, + { + "input": "Definition: Neuropeptides described as cocaine- and amphetamine-regulated transcript protein (116 aa, ~13 kDa) is encoded by the human CARTPT gene. This protein plays a role in the inhibition of appetite.\nConcepts: Uterine Corpus Leiomyoma with Bizarre Nuclei (Bizarre leiomyoma)\tINTRAMANDIBULAR (Functional Concept)\tWnt-activated signaling pathway involved in heart development (Wnt Signaling Pathway)\tCocaine- and Amphetamine-Regulated Transcript Protein (Amino Acid, Peptide, or Protein)\t1-20 INFLAMMATORY ARTHROPATHIES (Limb structure)", + "output": "Cocaine- and Amphetamine-Regulated Transcript Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Chronic Lymphocytic Leukemia described as a mature B- or T- cell leukemia with progressive clinical course. It is characterized by the presence of medium-sized lymphocytes with visible nucleoli (prolymphocytes) in the peripheral blood, bone marrow, and spleen.\nConcepts: Digital Mammography Detectors (Detectors, X-Ray, Digital Radiography)\tstress granule assembly (Genetic Function)\tAbsorbance Unit (Optical density units)\tContinuous Distribution (Quantitative Concept)\tProlymphocytic leukemia -RETIRED- (Chronic leukemia)", + "output": "Prolymphocytic leukemia -RETIRED- (Chronic leukemia)" + }, + { + "input": "Definition: something described as a question about how long an individual could live at their current address and standard of living if they lost their income source and lived off of savings.\nConcepts: If Lose Current Income Sources and Live Off Savings, How Long Could Continue to Live at Current Address and Standard of Living (Intellectual Product)\tAutosomal recessive secondary polycythaemia not associated with VHL (Von Hippel Lindau) gene (Congenital Disorders)\tSummary (Mean) P Wave Height (Quantitative Concept)\tHBV Surface Antibody (Immunologic Factor)\tIothalamate Clearance (Laboratory Procedure)", + "output": "If Lose Current Income Sources and Live Off Savings, How Long Could Continue to Live at Current Address and Standard of Living (Intellectual Product)" + }, + { + "input": "Definition: Experimental Organism Finding described as abnormal development of the adnexal appendages of the skin.\nConcepts: Concanavalin A (Plant mutagen)\tIVD Panels, Human Genetics, Metabolic Disorder, Urea Cycle Disorder, Mutation (Medical Device)\tHigh Affinity IL-2 Receptor Subunit Beta Positive (Positive Laboratory Test Result)\tADNEXAL DYSPLASIA (Disease or Syndrome)\tpN2 Lung Cancer (Finding)", + "output": "ADNEXAL DYSPLASIA (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a disc composed of either two or three cell layers (bilaminar or trilaminar) depending on the stage of embryonic development, the second or third week respectively. This disc gives rise to germ layers that will begin to differentiate the embryo. A layer of prismatic cells that forms the floor of the amniotic cavity, and from which the embryo develops.\nConcepts: Embryonic disc (Early differentiated embryonic structure)\tcephalosporinase activity (beta-lactamase activity)\tExclusive Provider Organization (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tadenylylsulphate-ammonia adenylyltransferase activity (Molecular Function)\tQLES179 (Intellectual Product)", + "output": "Embryonic disc (Early differentiated embryonic structure)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: My child's back feels stiff.\nConcepts: Mucinous Tumor of Ovary (Neoplastic Process)\tRADIOASSAY, 17-HYDROXYCORTICOSTEROIDS (Medical Device)\tASEX-Male Version - Reach Orgasm (Intellectual Product)\tPQL1306 (Intellectual Product)\tUDPglucose:gallate beta-D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)", + "output": "PQL1306 (Intellectual Product)" + }, + { + "input": "Definition: Country described as a republic in eastern Africa bounded on the north by RWANDA and on the south by TANZANIA. Its capital is Bujumbura.\nConcepts: Republic of Burundi (Africa, Eastern)\tChristian Science support written 90 minutes (Therapeutic or Preventive Procedure)\tpeptidyl-glutamate ADP-deribosylation (protein de-ADP-ribosylation)\tFAP-specific CD8-positive T Cells (Chimeric Antigen Receptor T-cells)\tGrade 3 Edema limbs (Finding)", + "output": "Republic of Burundi (Africa, Eastern)" + }, + { + "input": "Definition: Intellectual Product described as test names of clinical classification questions associated with the Negative Symptom Assessment-16 (NSA-16) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: CDISC Clinical Classification NSA-16 Test Name Terminology (CDISC Clinical Classification Terminology)\tTumour stage T1b (Tumor stage T1)\tGrade 2 Conventional (Clear Cell) Renal Cell Carcinoma (Conventional (Clear Cell) Renal Cell Carcinoma)\tDesensitization (Therapeutic immunosuppression)\tT/G mismatch-specific endonuclease activity (Genetic Function)", + "output": "CDISC Clinical Classification NSA-16 Test Name Terminology (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Organization described as a functional structure, such as a club, sorority, fraternity, or the personnel of such a structure whose purpose is for social interactions; organizations which provide an environment encouraging social interactions through group activities or individual relationships.\nConcepts: maintenance of seed dormancy by absisic acid (maintenance of seed dormancy)\tCLFTAUW (Quantitative Concept)\tsocial organization (Organization)\tAutologous Stem Cell Transplant Recipient (Patient or Disabled Group)\tDistal 22q11.2 microduplication syndrome (Disease or Syndrome)", + "output": "social organization (Organization)" + }, + { + "input": "Definition: funding grant described as a training program designed to provide financial support for professional development in a specific field.\nConcepts: rhabdomyosarcoma, previously treated, childhood (Musculoskeletal System Finding)\tdown regulation of lung goblet cell differentiation (negative regulation of epithelial cell differentiation)\tPCNSD (Mass Measurement)\tSCYB5 (Gene or Genome)\tFellowship Programs (Governmental or Regulatory Activity)", + "output": "Fellowship Programs (Governmental or Regulatory Activity)" + }, + { + "input": "Definition: Device Component or Accessory described as a device component designed with a hemispherical shape.\nConcepts: oestrogens (Hormone)\tpbc (Liver)\tregulation of viral penetration into host cell (Cell Function)\tDome (Device Component or Accessory)\tanthramycin (Organic Chemical)", + "output": "Dome (Device Component or Accessory)" + }, + { + "input": "Definition: Diagnostic Procedure described as a procedure used to mark a small area of abnormal tissue so it can be removed by surgery. An imaging device is used to guide a thin wire with a hook at the end through a hollow needle to place the wire in or around the abnormal area. Once the wire is in the right place, the needle is removed and the wire is left in place so the doctor will know where the abnormal tissue is. The wire is removed when a biopsy is done.\nConcepts: upregulation of transferase activity (positive regulation of catalytic activity)\tQ23H (Temporal Concept)\tblastema (Histogenic Process)\tWire-Guided Localization (Diagnostic Procedure)\tPitt Hopkins-like syndrome (Hereditary disorder of nervous system)", + "output": "Wire-Guided Localization (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as the component of the plasma membrane consisting of the gene products that penetrate only the cytoplasmic side of the membrane.\nConcepts: Regulating urination (Daily or Recreational Activity)\tIntercurrent Illness (Epidemiologic Factors)\tElectrocardiography/Vital Signs Telemetric Monitors (Medical Device)\t68Ga-PSMA-11-Gadoxetate (Contrast Media)\tintegral component of the cytoplasmic side of the plasma membrane (intrinsic component of the cytoplasmic side of the plasma membrane)", + "output": "integral component of the cytoplasmic side of the plasma membrane (intrinsic component of the cytoplasmic side of the plasma membrane)" + }, + { + "input": "Definition: Polysomnography described as the total amount of sleep time from sleep onset to sleep offset, determined by summing the N1 sleep, N2 sleep, N3 sleep, and REM sleep durations.\nConcepts: CPAP oxygen nasal cannula (Oxygen nasal cannula)\tTotal Sleep Time (Polysomnography)\tAt birth (Qualitative Concept)\tGlutamic Acid Decarboxylase 2 Antibody (Protein or Enzyme Type Measurement)\t9a (area 9 of Vogts)", + "output": "Total Sleep Time (Polysomnography)" + }, + { + "input": "Definition: Genetic Function described as any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.\nConcepts: viscerosensory nuclei (Body Part, Organ, or Organ Component)\tregulation of histone ubiquitination (Ubiquitination Regulation Protein)\ttobacco abuse education (Educational Activity)\tRecombinant Attenuated Salmonella typhimurium Expressing IL-2 (Antineoplastic Biological Agent)\tPronephric Duct (Embryonic Structure)", + "output": "regulation of histone ubiquitination (Ubiquitination Regulation Protein)" + }, + { + "input": "Definition: ACE INHIBITORS, PLAIN described as a non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, moexipril is hydrolyzed into its active form moexiprilat, which competitively inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the actions of the potent vasoconstrictor angiotensin II and leads to vasodilation. It also prevents angiotensin II-induced aldosterone secretion by the adrenal cortex, thereby promoting diuresis and natriuresis.\nConcepts: moexipril (Organic Chemical)\tReferral to medical emergency team (Referral to service)\tEpstein-Barr virus antibody positive (Serology: virus identified procedure)\tDry eye syndromes (Lacrimal Apparatus Diseases)\tExtensor plantar response (Plantar reflex)", + "output": "moexipril (Organic Chemical)" + }, + { + "input": "Definition: Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7 described as stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0);. IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a (lip): Tumor invades through cortical bone, inferior alveolar nerve, floor of mouth, or skin of face, i.e., chin or nose. T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases internal carotid artery. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension; or in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension; or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in dimension. N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension. N2c: Metastasis in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. N3: Metastasis in a lymph node more than 6 cm in greatest dimension. M1: Distant metastasis.\nConcepts: Prominent digit pad (Anatomical Abnormality)\tPhysostigmas (Plant)\tStage IV Carcinoma of the Lip (Lip Carcinoma)\tAuditory Continuous Performance Test (Research or Clinical Assessment Tool)\tCyclins, Type T (Amino Acid, Peptide, or Protein)", + "output": "Stage IV Carcinoma of the Lip (Lip Carcinoma)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as betaine derivative constituent of skeletal muscle and liver; required for mitochondrial beta oxidation of fatty acids; used therapeutically to stimulate gastric and pancreatic secretions and in the treatment of hyperlipoproteinemias.\nConcepts: vascular system development (system development -- biological)\t(3-Carboxy-2-hydroxypropyl)trimethylammonium Hydroxide Inner Salt (C [Preparations])\tmilligram per hour (Unit of Mass Flow Rate)\tToxicological Concepts (Biologic Function)\tAbnormal muscle glycogen content (Anatomical Abnormality)", + "output": "(3-Carboxy-2-hydroxypropyl)trimethylammonium Hydroxide Inner Salt (C [Preparations])" + }, + { + "input": "Definition: Organic Chemical described as a vaccine containing a pancarcinoma carbohydrate antigen conjugated with keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Sialylated Tn antigen (sTn) is a monosaccharide glycan usually O-linked to serine or threonine residues of mucins found on most epithelial cancers. Conjugation with KLH, a hapten carrier and an immunostimulant, improves host immune responses. Vaccination with sTn-KLH vaccine may produce antibodies and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing sTn, resulting in decreased tumor growth.\nConcepts: tartrate epimerase activity (racemase and epimerase activity, acting on hydroxy acids and derivatives)\tSTn-KLH Vaccine (Immunologic Factor)\tIntratubular light-chain casts (Renal intratubular casts)\tFAM55A (Genes, Regulator)\tTargeted Molecular Therapy Was Not Administered as an Additional Treatment for a New Tumor Event (Finding)", + "output": "STn-KLH Vaccine (Immunologic Factor)" + }, + { + "input": "Definition: Cervical Cancer by AJCC v7 Stage described as cancer has spread to the lower third of the vagina and may have spread to the pelvic wall (the tissues that line the part of the body between the hips), and nearby lymph nodes. Stage III is divided into stages IIIA and IIIB, based on now far the cancer has spread. In stage IIIA, cancer has spread to the lower third of the vagina but not to the pelvic wall. In stage IIIB, cancer has spread to the pelvic wall and/or the tumor has become large enough to block the ureters (the tubes that connect the kidneys to the bladder). This blockage can cause the kidneys to enlarge or stop working. Cancer may also have spread to lymph nodes in the pelvis.\nConcepts: Vitiligo vulgaris (Immunology)\tMeasured intake of alpha-linoleic acid in 24 hours (Quantitative Concept)\tSabals (Plant)\t17 beta-acetoxyestra-4,9,11-trien-3-one (Organic Chemical)\tStage III Cervical Cancer (Neoplastic Process)", + "output": "Stage III Cervical Cancer (Neoplastic Process)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the minichromosome maintenance complex component 6 (MCM6) gene, located at chromosome 2q21.3, which encodes the protein DNA replication licensing factor MCM6. Mutations at this locus have been identified in patients with non-persistence of intestinal lactase (i.e., lactose intolerance).\nConcepts: grasp reflex (Reflex Motor and Equilibrium Functions)\tleukemia mast cell aleukemic (Mastocytosis, Systemic)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MCM6 (Medical Device)\tNCCN-FACT-FPSI 17 Version 2 - Content With Quality of My Life (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)\tCVA, Cerebrovascular Accident (CNS GENERAL)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MCM6 (Medical Device)" + }, + { + "input": "Definition: positive regulation of T cell activation described as any process that activates or increases the frequency, rate or extent of alpha-beta T cell activation.\nConcepts: Stage IB Pleural Malignant Mesothelioma AJCC v7 (Stage I Pleural Malignant Mesothelioma AJCC v7)\tViper retrovirus (Virus)\tpositive regulation of pancreatic juice secretion (regulation of pancreatic juice secretion)\tGrade 3 Exostosis, CTCAE (Finding)\tpositive regulation of alpha-beta T-cell activation (positive regulation of T cell activation)", + "output": "positive regulation of alpha-beta T-cell activation (positive regulation of T cell activation)" + }, + { + "input": "Definition: Occupation or Discipline described as a homemaker whose work includes caring for children.\nConcepts: Stay-at-Home Parent (Occupation or Discipline)\tDarwin tubercle of helix (Abnormality of the helix)\tComplete or partial transverse disruption (Disruption)\tUnified Huntington's Disease Rating Scale '99 Clinical Classification Test Code (CDISC Clinical Classification Terminology)\tClark Level II (Finding)", + "output": "Stay-at-Home Parent (Occupation or Discipline)" + }, + { + "input": "Definition: Finding described as a response indicating that 2 things are equally likely.\nConcepts: QLES1-Concentrated on Course Work (Q-LES-Q Questionnaire Question)\tNeobladder (Surgically-Created Structures)\tEqually Likely (Finding)\tEncephalopathy of Prematurity (Disease or Syndrome)\tPositive and Negative Syndrome Scale Clinical Classification Test Code (Intellectual Product)", + "output": "Equally Likely (Finding)" + }, + { + "input": "Definition: ACC-AHA Measure described as factors causing the chief complaint to worsen.\nConcepts: RESPIRATORY SYSTEM DIAG TECHNIQUES (Diagnosis)\tMonitor, Image Quality Poor (Improper Medical Device Output)\tStructurally Diverse Substance (Substance)\tAVL01027 (Intellectual Product)\tAggravating Factor to Chief Complaint (ACC-AHA Measure)", + "output": "Aggravating Factor to Chief Complaint (ACC-AHA Measure)" + }, + { + "input": "Definition: Lesion of neck described as a calcification of the posterior longitudinal ligament of the spinal column, usually at the level of the cervical spine. It is often associated with anterior ankylosing hyperostosis.\nConcepts: Language Translation (Publications)\tOssification post longit lig (Musculoskeletal and connective tissue disorders)\t9q33-q34 (Cell Component)\tEducation about use of supporting device (Educational process of instructing)\tMSG1-Related Gene 1 Gene (CITED2 gene)", + "output": "Ossification post longit lig (Musculoskeletal and connective tissue disorders)" + }, + { + "input": "Definition: something described as situation in which both partners or spouses in a family pursue careers.\nConcepts: Yellow Fever Virus Antibody Measurement (Viral serologic study)\tDual Careers (Thesaurus of Psychological Index Terms)\tProtein, Extracellular Matrix (Amino Acid, Peptide, or Protein)\tSH3 Domain (Protein Binding Motif)\tGlottic Cancer pT0 TNM Finding v6 and v7 (Finding)", + "output": "Dual Careers (Thesaurus of Psychological Index Terms)" + }, + { + "input": "Definition: something described as the physical restoration of oromandibular defects.\nConcepts: Reconstructions, Mandibular (Therapeutic or Preventive Procedure)\tCreatine Kinase, Macromolecular Type 2/Total Creatine Kinase (Laboratory Procedure)\tUpper motor neurone type of dysarthria (Dysarthria)\tGenomic Data Commons (Cancer Research)\tallelic gene (Genes)", + "output": "Reconstructions, Mandibular (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Medical Device described as a blood access device and accessories is a device intended to provide access to a patient's blood for hemodialysis or other chronic uses. When used in hemodialysis, it is part of an artificial kidney system for the treatment of patients with renal failure or toxemic conditions and provides access to a patient's blood for hemodialysis. The device includes implanted blood access devices, nonimplanted blood access devices, and accessories for both the implanted and nonimplanted blood access devices. (1) The implanted blood access device consists of various flexible or rigid tubes, which are surgically implanted in appropriate blood vessels, may come through the skin, and are intended to remain in the body for 30 days or more. This generic type of device includes various shunts and connectors specifically designed to provide access to blood, such as the arteriovenous (A - V) shunt cannula and vessel tip. (2) The nonimplanted blood access device consists of various flexible or rigid tubes, such as catheters, cannulae or hollow needles, which are inserted into appropriate blood vessels or a vascular graft prosthesis (Secs. 870.3450 and 870.3460), and are intended to remain in the body for less than 30 days. This generic type of device includes fistula needles, the single needle dialysis set (coaxial flow needle), and the single needle dialysis set (alternating flow needle). (3) Accessories common to either type include the shunt adaptor, cannula clamp, shunt connector, shunt stabilizer, vessel dilator, disconnect forceps, shunt guard, crimp plier, tube plier, crimp ring, joint ring, fistula adaptor, and declotting tray (including contents).\nConcepts: Progressive cone degeneration (Eye)\tN-(5-chloro-1,3-benzodioxol-4-yl)-7-(2-(4-methylpiperazin-1-yl)ethoxy)-5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine (Antineoplastic Enzyme Inhibitor)\tFascial Unwinding (Therapeutic or Preventive Procedure)\tFORCEPS, DISCONNECT (Medical Device)\tTonsillectomy, NOS (Excision of head structure)", + "output": "FORCEPS, DISCONNECT (Medical Device)" + }, + { + "input": "Definition: something described as the smaller lobe of the liver extending into the left side of the body.\nConcepts: 2 (Finding)\tD3-Type Cyclin Gene (Gene or Genome)\tLobus hepatis sinister (Body Part, Organ, or Organ Component)\tmalignant neoplasm of bone marrow (Malignant Neoplasms)\tFemale Reproductive Systems (Adult human body)", + "output": "Lobus hepatis sinister (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Plant described as the club-moss plant family of the order Lycopodiales, class Lycopodiopsida, division Lycopodiophyta, subkingdom TRACHEOPHYTA. The common name of clubmoss applies to several genera of this family. Despite the name this is not one of the true mosses (BRYOPSIDA ).\nConcepts: Mosses, Club (Embryophyta)\tcross cultural differences (Qualitative Concept)\tEpstein-Barr Early D Antigen IgG Antibody Measurement (Laboratory Procedure)\tNACA 0 (Finding)\tCapsules, Dental Amalgam, Disposable (Medical Device)", + "output": "Mosses, Club (Embryophyta)" + }, + { + "input": "Definition: Workers described as the body of teachers and administrators at a school.\nConcepts: single-stranded 3'-5' DNA helicase activity (Genetic Function)\tsemen (Body part)\tFaculty (Educational Personnel)\tHS.84084 (APPBP2 gene)\tContent Creation Date (Temporal Concept)", + "output": "Faculty (Educational Personnel)" + }, + { + "input": "Definition: Procedure Pack/Kit/Tray/Sets described as prepackaged collections of the devices and supplies (either custom or standard) needed for performing a specific clinical procedure on a patient. Items in these kits usually include most or all the instruments and supplies needed to perform the procedure. These kits are frequently supplied in supporting trays (i.e., procedure trays) consisting of a flat-bottomed receptacle with a border around the periphery supporting all the instruments and supplies needed for the procedure; the trays are usually covered or wrapped. Procedure kits and trays are mainly intended for use during diagnostic and/or therapeutic procedures. Dedicated procedure kits and trays are available for a variety of procedures, such as acupuncture, amniocentesis, anesthesia, angiography, biopsy, blood culture, and catheterization.\nConcepts: CSS0502C (Intellectual Product)\tLong rib cage (Form of thorax - finding)\tHas concentration strength numerator value (Concept model object attribute)\tProcedure Tray/Kits (Procedure Pack/Kit/Tray/Sets)\tcellular response to nitrite (cellular response to oxygen-containing compound)", + "output": "Procedure Tray/Kits (Procedure Pack/Kit/Tray/Sets)" + }, + { + "input": "Definition: Perfusion of limb described as a procedure used to deliver anticancer drugs directly to an arm or leg but not to the rest of the body. The flow of blood to and from the limb is temporarily stopped with a tourniquet (a tight band around the limb). Catheters (small, flexible tubes) attached to a pump are put into an artery and a vein in the limb so that blood can be circulated through the pump into the limb. Anticancer drugs are injected into the catheters. Wrapping the limb in a heated blanket or warming the drugs or blood may help the drugs work better.\nConcepts: ACHANG (Ethnic group)\tnuclear aberrant ncRNA catabolic process (Genetic Function)\tisolated limb infusion (Perfusion of limb)\tHigh glutamine levels in cerebrospinal fluid (Abnormal CSF glutamine concentration)\t(3'-5')d(P-thio)(T-C-G-T-C-G-T-T-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T) Tricosasodium Salt (Immunologic Adjuvants)", + "output": "isolated limb infusion (Perfusion of limb)" + }, + { + "input": "Definition: Cell septum described as a septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments.\nConcepts: Pudelpointer (Dog family)\tpost-lysosomal vacuole (Early endosome)\tOlfactory Region (Nervous System Part)\tporous cell septum (Cell septum)\tKnow Who to Contact for Questions (Clinical or Research Assessment Answer)", + "output": "porous cell septum (Cell septum)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.\nConcepts: Carbamic acid, (5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-, methyl ester (Benzimidazoles)\tregulation of double-strand break repair via homologous recombination (regulation of DNA recombination)\tCyrcadia Health Circadian Biometric Recorder (Manufactured Object)\tSensorineural hearing loss, early greying, essential tremor syndrome (Auditory system hereditary disorder)\tIncreased VLDL cholesterol concentration (Abnormal VLDL cholesterol concentration)", + "output": "regulation of double-strand break repair via homologous recombination (regulation of DNA recombination)" + }, + { + "input": "Definition: Neoplastic Process described as a neoplastic process characterized by the proliferation of spindle to cuboidal myoepithelial cells within small breast ducts.\nConcepts: Intraductal Breast Myoepitheliosis (Neoplastic Process)\thypercalcinemia (ENDOCRINE FEATURES)\t4-aminobiphenyl N-acetyltransferase activity (N-acetyltransferase activity)\tLytotoxicity (Cell or Molecular Dysfunction)\tplexiform neuromas (Benign Neoplasm)", + "output": "Intraductal Breast Myoepitheliosis (Neoplastic Process)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that something occurs, but causes little concern.\nConcepts: Penicillium chrysogenum IgE Antibody (Immunologic Tests)\tA little, but it doesn't worry me (Intellectual Product)\tN-terminal peptidyl-proline dimethylation (N-terminal peptidyl-proline methylation)\tAVLT-REY - List B Word 11 (Intellectual Product)\tGrade 2 Menorrhagia (Finding)", + "output": "A little, but it doesn't worry me (Intellectual Product)" + }, + { + "input": "Definition: Biologically Active Substance described as protein ALEX (626 aa, ~68 kDa) is encoded by the human GNAS gene. This protein plays a role in the inhibition of adenylate cyclase-stimulating G alpha proteins.\nConcepts: Catching function (Hand and arm use)\tEHF (Transcription factor genes)\tGroup; Multi-Specialty (Professional or Occupational Group)\talpha-ribazole-5'-P phosphatase activity (phosphoric monoester hydrolase activity)\tProtein ALEX (Biologically Active Substance)", + "output": "Protein ALEX (Biologically Active Substance)" + }, + { + "input": "Definition: Telomere Maintenance described as any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA.\nConcepts: Fluoren 2 ylacetamide (Organic Chemical)\tInframe Deletion (Inframe Mutation)\ttelomere maintenance via telomere lengthening (Genetic Function)\tresponse times (Psychophysiology)\tDNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activator activity (DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) regulator activity)", + "output": "telomere maintenance via telomere lengthening (Genetic Function)" + }, + { + "input": "Definition: Molecular Biology described as the study of the regulation of gene expression by nuclear receptors. Includes the mechanisms by which receptors are themselves regulated.\nConcepts: C-SSRS Since Last Visit - Description of Preparatory Acts or Behaviors Toward Suicide Attempt (Intellectual Product)\tpep (Organic Chemical)\tAlkaline Phosphatase Isoenzyme Measurement (Protein or Enzyme Type Measurement)\t(-)-1-(((6R,7R)-7-(2-(5-Amino-1,2,4-Thiadiazol-3-yl)Glyoxylamido)-2-Carboxy-8-Oxo-5-Thia-1-Azabicyclo(4.2.0)Oct-2-en-3-yl)Methyl)-1h-Imidazo(1,2-B)Pyridazin-4-Ium Hydroxide Inner Salt, 7(Sup 2)-(Z)-(O-Methyloxime), Hydrochloride (Pharmacologic Substance)\tReceptor Biology and Gene Expression (Molecular Biology)", + "output": "Receptor Biology and Gene Expression (Molecular Biology)" + }, + { + "input": "Definition: regulation of paraxial mesodermal cell fate determination described as any process that stops, prevents, or reduces the frequency, rate or extent of paraxial mesoderm cell fate determination.\nConcepts: Neuropiles (Anatomical organizational pattern)\tBACOAIND (Finding)\tHernioplasties (Reparative closure)\tWHODAS 2.0 12+24-item Version Interviewer-administered - Starting or Maintaining Conversation (Intellectual Product)\tnegative regulation of paraxial mesodermal cell fate determination (regulation of paraxial mesodermal cell fate determination)", + "output": "negative regulation of paraxial mesodermal cell fate determination (regulation of paraxial mesodermal cell fate determination)" + }, + { + "input": "Definition: Health Personnel described as occupations directed to the diagnosis, cure and prevention of disease or clinical care of children and adolescents.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, KCNQ4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tmeasle (Korean Standard Classification of Disease Version 5)\tSAP 155 Val701Xxx (Cell or Molecular Dysfunction)\tchild health care personnel (Health Personnel)\tCEREBRAL AMYLOID ANGIOPATHY FAMILIAL (Amyloidosis, Familial)", + "output": "child health care personnel (Health Personnel)" + }, + { + "input": "Definition: Genetic Diseases, X-Linked described as syndrome that is characterized by intellectual deficit, deafness, ocular anomalies, T-cell leukemia, cryptorchidism, hypospadias and spasticity. Mutations in DNA polymerase alpha, leading to increased chromosome breakage, may be responsible for the syndrome. X-linked recessive transmission has been proposed.\nConcepts: PQL1417 (PedsQL Neuromuscular Module Acute Version 3.0 Child Report Questionnaire Question)\tN syndrome (Disease or Syndrome)\tbirth control method (Contraception status)\tGeotrichum species (Form family Moniliaceae)\t1,3-Benzodioxole, 5-(2-propenyl)- (PLANT ALDEHYDE, KETONE AND PHENOL OILS)", + "output": "N syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about how frequently an individual's voice makes them feel handicapped.\nConcepts: Exercisers (Medical Devices)\tRight unicoronal synostosis (Anatomical Abnormality)\tDepot Extended Release Dosage Form (Biomedical or Dental Material)\tCorrected Age (Age)\tMy voice makes me feel handicapped (Clinical or Research Assessment Question)", + "output": "My voice makes me feel handicapped (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a decrease in the incidence and frequency of SMOKING. Smoking reduction differs from SMOKING CESSATION in that the smoker continues to smoke albeit at a lesser frequency without quitting.\nConcepts: regulation of intracellular protein transport (regulation of intracellular transport)\tresponse to glycine (Organism Function)\tSH3 Domain-Containing Protein 1A (Amino Acid, Peptide, or Protein)\tp33ING2 (Gene or Genome)\tReduction, Smoking (Smoking)", + "output": "Reduction, Smoking (Smoking)" + }, + { + "input": "Definition: Spiritual nursing care described as completing a patient's facility incident report while remaining consistent with his or her religious beliefs. Service is billed in 15-minute increments.\nConcepts: negative regulation of Th17 fate commitment (regulation of T-helper 17 cell lineage commitment)\tDecerebration (Neurosurgical Procedures)\tSpiritual nurse facility-incident report each 15 minutes (Health Care Activity)\tObservationResultActionTakenRelationship (Relationships)\tPregnancy, normal (Patient currently pregnant)", + "output": "Spiritual nurse facility-incident report each 15 minutes (Health Care Activity)" + }, + { + "input": "Definition: Ecosystem described as marine ridges composed of living CORALS, coral skeletons, calcareous algae, and other organisms, mixed with minerals and organic matter. They are found most commonly in tropical waters and support other animal and plant life.\nConcepts: Reefs, Coral (Natural Phenomenon or Process)\tBifidobacterium breve Reuter 1963 (B [Preparations])\t11\u03b2,21-dihydroxy-17\u03b1-butyryloxy-4-pregnene-3,20-dione (11-oxycorticosteroid)\tCell Pellet (Biospecimen)\tFAC00836 (Intellectual Product)", + "output": "Reefs, Coral (Natural Phenomenon or Process)" + }, + { + "input": "Definition: plastid large ribosomal subunit described as the large subunit of a ribosome contained within a chloroplast.\nConcepts: Ineffective infant feeding dynamics (Ingestion)\tCount, Bacterial (Colony Count, Microbial)\tchloroplast ribosomal LSU complex (Cell Component)\taliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming) activity (acid-D-amino acid ligase activity)\tMucoepidermoid Carcinomas (Neoplastic Process)", + "output": "chloroplast ribosomal LSU complex (Cell Component)" + }, + { + "input": "Definition: Cell Growth Processes described as the complex series of phenomena occurring after cell division and before cell death.\nConcepts: growth of cell (Growth)\ttracheoesophageal septum formation (Organ or Tissue Function)\tADENOSINE A2A RECEPTOR (Gene or Genome)\tRecurrent Lip and Oral Cavity Squamous Cell Carcinoma (Lip and Oral Cavity Squamous Cell Carcinoma)\tSensitive (Qualitative Concept)", + "output": "growth of cell (Growth)" + }, + { + "input": "Definition: Finding described as reflux that fills and grossly dilates the ureter and collecting system with blunting of the calyces. Some tortuosity of the ureter is also present.\nConcepts: Grade IV Vesicoureteral Reflux (Finding)\tSweet Verbena Oil (Organic Chemical)\tACCESSORIES, CLEANING, FOR ENDOSCOPE (Medical Device)\tRegular Smokeless Tobacco Use for Six Weeks or More Unknown (Finding)\tHemipelvectomy Type III (Hemipelvectomy)", + "output": "Grade IV Vesicoureteral Reflux (Finding)" + }, + { + "input": "Definition: something described as a joint research venture of MIT and Harvard, established in 2004 to improve human health by using genomics to advance an understanding of the biology and treatment of human disease, and to help lay the groundwork for a new generation of therapies.\nConcepts: Broad Institute of MIT and Harvard (Health Care Related Organization)\tpositive regulation by symbiont of RNA levels in host (Organism Function)\tNCOA6 wt Allele (Gene or Genome)\tmesenchymal cell differentiation involved in lung development (Cell Function)\tBLEPHAROSPASM (Vision Disorders)", + "output": "Broad Institute of MIT and Harvard (Health Care Related Organization)" + }, + { + "input": "Definition: Menopause Status described as prior to menopause.\nConcepts: Insomnia due to Organic Factor (Sleeplessness)\tPainful Ache in Mouth due Problem with Teeth, Denture or Mouth (Intellectual Product)\tPremenopausal - menopausal status (Finding)\tbeta-2 glycoprotein 1 IgM antibody measurement (Immunologic Tests)\turtica urens/stinging nettle (U [Preparations])", + "output": "Premenopausal - menopausal status (Finding)" + }, + { + "input": "Definition: Genetic Function described as a protein, or a member of a complex, or a non-coding RNA that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units.\nConcepts: Tomography, Optical (tomography)\tGel (Basic Dosage Form Category)\t(9E)-Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime] (erythromycin)\tDNA-binding transcription activator activity, RNA polymerase II-specific (Genetic Function)\tClathrin, Heavy Polypeptide (Hc) Gene (Gene or Genome)", + "output": "DNA-binding transcription activator activity, RNA polymerase II-specific (Genetic Function)" + }, + { + "input": "Definition: something described as a device with demonstrated safety in the MR environment within defined conditions. At a minimum, address the conditions of the static magnetic field, the switched gradient magnetic field and the radiofrequency fields. Additional conditions, including specific configurations of the item, may be required. See ASTM F2503.\nConcepts: Functional Activities Questionnaire-NACC Version Questionnaire Test Name (Intellectual Product)\tIVD Test Reagent/Kits, Microbiology, Buffer (Medical Device)\tTemperatures (Kind of quantity)\tMagnetic Resonance Conditional (Magnetic Resonance Imaging Safety Labeling Information)\tBody Schema (Qualitative Concept)", + "output": "Magnetic Resonance Conditional (Magnetic Resonance Imaging Safety Labeling Information)" + }, + { + "input": "Definition: Organ or Tissue Function described as a process that modulates synaptic scaling. Synaptic scaling is a form of synaptic plasticity, which entails uniform adjustments in the strength of all synapses on a cell in response to prolonged changes in the electrical activity of the cell.\nConcepts: regulation of synaptic scaling (regulation of synaptic plasticity)\tPMB Drug Company Contact (Professional or Occupational Group)\tLife Sciences Identifier (Unique Identifier)\tCDISC Integrated Occurrence Data Structure Dataset (Data Set)\tOxicodona (Phenanthrenes)", + "output": "regulation of synaptic scaling (regulation of synaptic plasticity)" + }, + { + "input": "Definition: something described as specifies wheter a subject has had prior exposure to steroids.\nConcepts: Asian-American (Asian Continental Ancestry Group)\tprotein kinase A catalytic subunit binding (Molecular Function)\tFACT-C Version 4 - Swelling/Cramps in Stomach Area (Intellectual Product)\tprior steroid exposure (Previous Exposure Indicator)\tcalcitonin receptor activity (calcitonin family receptor activity)", + "output": "prior steroid exposure (Previous Exposure Indicator)" + }, + { + "input": "Definition: Neostriatum described as nucleus in the NEOSTRIATUM of bird brains that sends signals for song production and receives auditory input. In some adult SONGBIRDS, research has shown that the size of this nucleus changes seasonally and that it exhibits neurogenesis.\nConcepts: Nausea Distress (Clinical or Research Assessment Question)\tVocal Center, High (Body Part, Organ, or Organ Component)\tupregulation of viral protein biosynthesis (Genetic Function)\tCD28 Gene (Receptor Gene)\tLymphocyte-Specific Adapter Protein Lnk (Adaptor Proteins, Signal Transducing)", + "output": "Vocal Center, High (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Abnormal oral morphology described as an abnormality of a mandible coronoid process.\nConcepts: C-SSRS Pediatric/Cognitively Impaired Lifetime/Recent - Description of Preparatory Acts or Behaviors Toward Suicide Attempt (C-SSRS Pediatric Cognitively Impaired Lifetime Recent Questionnaire Question)\tStage I Esophageal Adenocarcinoma (Neoplastic Process)\tAbnormal mandible coronoid process morphology (Abnormality of the mandible)\t12: 122642993-122630453 (Chromosome 12 Physical Location)\tacoustic nerve (Auditory pathway structure)", + "output": "Abnormal mandible coronoid process morphology (Abnormality of the mandible)" + }, + { + "input": "Definition: Congenital abnormality of skull shape described as cranial region of head appears more elevated and rounded than normal. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)\nConcepts: EC 5.3.1.9 (Aldose-Ketose Isomerases)\tINJECTION, SOLUTION, CONCENTRATE (Concentrated Solution Dosage Form)\tMelanoma of the Conjunctiva cT1d TNM Finding v7 (Finding)\tUterine Corpus Carcinoma and Carcinosarcoma pT0 TNM Finding v8 (Uterine Corpus Carcinoma and Carcinosarcoma Pathologic Primary Tumor TNM Finding v8)\tDome-Shaped Head (Other Finding)", + "output": "Dome-Shaped Head (Other Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a monoclonal antibody agonist of the cell surface receptor CD40, with potential immunostimulatory and antineoplastic activities. Similar to the endogenous CD40 ligand (CD40L or CD154), CD40 agonist monoclonal antibody RO7009789 binds to CD40 on a variety of immune cell types. This triggers the cellular proliferation and activation of antigen-presenting cells (APCs), and activates B cells and T cells, resulting in an enhanced immune response. RO7009789 also binds to and activates CD40 present on the surfaces of some solid tumor cells, leading to apoptosis and decreased tumor growth. CD40, a cell surface receptor and member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on various immune cells and certain cancer cells; it mediates both indirect tumor cell killing through the activation of the immune system and direct tumor cell apoptosis. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C119740\" active clinical trials using this agent.\nConcepts: Synthetic Melanoma-Associated Antigens Vaccine (Pharmacologic Substance)\t4-hydroxyphenylacetate metabolic process (monocarboxylic acid metabolic process)\tNon-Proliferative Fibrocystic Change (Breast Fibrocystic Disease)\tCD40 agonist monoclonal antibody RO7009789 (Amino Acid, Peptide, or Protein)\tfg/mL/m2 (Quantitative Concept)", + "output": "CD40 agonist monoclonal antibody RO7009789 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Activity described as a method whereby a subject is allowed to recover for a specific period of time after an activity before it is euthanized.\nConcepts: Non carious cervical lesion (Tooth finding)\tGastrointestinal nonspecific symptoms and therapeutic procedures (Classification)\tOrder (Property or Attribute)\tIVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Comprehensive, Mutation (IVD Panels, Human Genetics, Encephalopathy, Epilepsy/Seizure Disorder, Comprehensive)\tRECOVERY SACRIFICE (Activity)", + "output": "RECOVERY SACRIFICE (Activity)" + }, + { + "input": "Definition: Spermatozoa.abnormal head described as a rare but severe cause of male infertility. It is characterized by the presence of 100% round headed spermatozoa and lack of acrosomes.\nConcepts: Hydroponics (Agriculture)\tRound-headed spermatozoa (Sperm head anomaly)\tFocal aware sensory seizure with auditory features (Focal aware sensory seizure)\tmuscle cell apoptotic process (Apoptosis)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GALC (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "Round-headed spermatozoa (Sperm head anomaly)" + }, + { + "input": "Definition: something described as the trihydrate form of a phosphorylated aminosulfhydryl compound. After dephosphorylation of amifostine by alkaline phosphatase to an active free sulfhydryl (thiol) metabolite, the thiol metabolite binds to and detoxifies cytotoxic platinum-containing metabolites of cisplatin and scavenges free radicals induced by cisplatin and ionizing radiation. The elevated activity of this agent in normal tissues results from both the relative abundance of alkaline phosphatase in normal tissues and the greater vascularity of normal tissues compared to tumor tissues.\nConcepts: Epithelial Cells (Cytodiagnosis)\tAmifostina (Organothiophosphates)\tfms (Chronic inflammatory disorder)\tDeleterious FAH Gene Mutation (Deleterious Mutation)\tBristol Stool Type 6 (Bristol Stool Scale)", + "output": "Amifostina (Organothiophosphates)" + }, + { + "input": "Definition: Retinopathy of Prematurity described as the accumulating neovascularization thickens and manifests as a linear bump. The neovascularization remains along the surface of the retina and does not extend off the retina into the cortical vitreous.\nConcepts: ETV6/EVI1 FusionProtein (Fusion protein)\tRetinopathy of Prematurity Stage 2 (Retinopathy of Prematurity Finding)\tShipping Fever Viruses (Respirovirus)\tAJCC TUMOR GRADE (Classification)\tLymphocytes increased above normal range (Raised hematology finding)", + "output": "Retinopathy of Prematurity Stage 2 (Retinopathy of Prematurity Finding)" + }, + { + "input": "Definition: something described as a type of carcinoma that comprises a minority of renal cell carcinomas. It is characterized by loss of chromosomes 1 and Y. Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic. It has a much better prognosis than other renal cell carcinomas. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C4146\" active clinical trials using this agent.\nConcepts: chromophobe carcinoma (Adenoma AND/OR adenocarcinoma)\tLAMP (Nucleic Acid Amplification Tests)\tInsulin resistance (Abnormal glucose homeostasis)\tHypopharyngeal Cancer pT4b TNM Finding v7 (Finding)\trespiratory tract disorders (Physical & Psychosomatic Disorders)", + "output": "chromophobe carcinoma (Adenoma AND/OR adenocarcinoma)" + }, + { + "input": "Definition: Spatial Concept described as a type of graph that uses a focus node with other nodes arranged in concentric circles around the focus to illustrate the central node's degree of connectivity to the other nodes.\nConcepts: Motion Related Artifact (Finding)\tloas (Filarioidea)\tFlexure (Other Anatomic Concept)\tDNA Viruses (Virus)\tGraph Radial Layout (Spatial Concept)", + "output": "Graph Radial Layout (Spatial Concept)" + }, + { + "input": "Definition: something described as a one of two areas of granulous cortex in the portion of the superior temporal gyrus that is hidden in the wall of the lateral fissure in the macaque. The other is area Kalt of Pandya. Defined on the basis of cytomyeloarchitecture, the areas are regarded functionally as auditory cortex. Both areas are distinguished by the density of the external granular layer (II), the external pyramidal layer (III), and the internal granular layer (IV), the light internal pyramidal layer (V) and the dense multiform layer (VI). Area Kam occupies \\\"the lateral slope of a small hill of the [temporal operculum]... area Kalt occupies a flat dimple lateral to Kam.\\\" Myeloarchitectonic differences between the two areas are more pronounced ( Pandya-1973 ). See also planum temporale.\nConcepts: Medullary Thyroid Carcinoma Pathologic Primary Tumor TNM Finding v8 (Medullary Thyroid Carcinoma Pathologic TNM Finding v8)\tCCL23 wt Allele (CCL23 gene)\tmedial koniocortex (Body Part, Organ, or Organ Component)\tReplicate (General adjectival modifier)\tWas ATRX Mutation Analysis Performed (Intellectual Product)", + "output": "medial koniocortex (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Genetic Function described as the RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction.\nConcepts: Patient isolation chamber (Medical Device)\tH-lignin biosynthetic process (lignin biosynthetic process)\tRNA exon ligation (RNA metabolic process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SHOX (Medical Device)\tBenign Neoplasm of the Duodenum (Duodenal Neoplasms)", + "output": "RNA exon ligation (RNA metabolic process)" + }, + { + "input": "Definition: something described as catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH.\nConcepts: Platelet Aggregation Amplitude (Hematologic Tests)\tHas your physical condition or medical treatment caused you financial difficulties (Findings-Based Question)\toxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor (Molecular Function)\tcis-ethylbenzene glycol dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tngEq/mL/mgEq (Quantitative Concept)", + "output": "cis-ethylbenzene glycol dehydrogenase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)" + }, + { + "input": "Definition: Body Location or Region described as describes a location in the mouth that is toward or near the tongue.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MTHFR (Medical Device)\tLingual (Anatomy Qualifier)\tH2B Gene (Histone H2 Gene)\tL-aspartate oxidase activity (L-amino acid oxidase activity)\tNeurophysiological Recruitment (Nerve conduction function)", + "output": "Lingual (Anatomy Qualifier)" + }, + { + "input": "Definition: something described as the study of the energy changes involved in physical and chemical reactions within a cell.\nConcepts: Cell Energetics (Biochemistry and Cellular Biology)\tGrade 3 Suicidal ideation (Suicidal Ideation, CTCAE)\tSphenobasilar symphysis (SBS) compression (Finding)\tL Threonine (Amino Acids)\tCarney-Stratakis dyad (Neoplastic Syndromes, Hereditary)", + "output": "Cell Energetics (Biochemistry and Cellular Biology)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify Enterovirus, a genus of single-stranded RNA viruses of the family Picornaviridae that includes polio and nonpolio (e.g., coxsackieviruses and echoviruses) enteroviruses, by detecting the ribonucleic acid (RNA) of the target virus. These viruses may cause a wide range of diseases, including poliomyelitis (the etiologic agents are wild type polioviruses), aseptic meningitis, and encephalitis (caused by several types of coxsackieviruses and echoviruses), as well as chronic meningoencephalitis (caused by several types of echoviruses).\nConcepts: chloroplast accumulation movement (Cell Function)\tGlobal Medical Device Nomenclature (Intellectual Product)\tmyocardium; calcification (Abnormal cardiac ventricle morphology)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Enterovirus, RNA (Medical Device)\tL-citrulline:L-aspartate ligase (Molecular Function)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Virus, Enterovirus, RNA (Medical Device)" + }, + { + "input": "Definition: Informed Consent Date described as the date (and time) the study subject gives official consent by signing the official consent form.\nConcepts: palmitic acid catabolic process (palmitic acid metabolic process)\tm[iU]/ml/mg (Quantitative Concept)\tnew10min xofc msg ther ntak (Remote location new client without ICD diagnosis)\tVaccenic Acid (Aliphatic carboxylic acid, C14-C26)\tPerformed Study Subject Milestone Informed Consent Date (Informed Consent Date)", + "output": "Performed Study Subject Milestone Informed Consent Date (Informed Consent Date)" + }, + { + "input": "Definition: Unit of Dose Calculation described as a unit of measure expressed in milliliter(s) per animal per period of time equal to seven days.\nConcepts: protein-fructosamine 3-kinase activity (catalytic activity, acting on a protein)\tmL/{animal}/wk (Quantitative Concept)\tMarginal Zone Lymphoma of the Spleen (Lymphoma, Non-Hodgkin)\tPROTEUS SYNDROME (Rare Non-Neoplastic Disorder)\tSilver nitrate [disinfectant] (Inorganic Chemical)", + "output": "mL/{animal}/wk (Quantitative Concept)" + }, + { + "input": "Definition: Genetic Function described as interacting selectively and non-covalently with a sequence of guanine residues in an RNA molecule.\nConcepts: Template (Intellectual Product)\tpoly(G) binding, within an RNA molecule (poly-purine tract binding)\tCholesterol (food allergen)\tgalactose transmembrane transport (Cell Function)\tbutane monooxygenase activity (Molecular Function)", + "output": "poly(G) binding, within an RNA molecule (poly-purine tract binding)" + }, + { + "input": "Definition: Neurotransmitter Agents described as any drug used for its actions on cholinergic systems. Included here are agonists and antagonists, drugs that affect the life cycle of ACETYLCHOLINE, and drugs that affect the survival of cholinergic neurons. The term cholinergic agents is sometimes still used in the narrower sense of MUSCARINIC AGONISTS, although most modern texts discourage that usage.\nConcepts: referenceTypeCode (Intellectual Product)\tsibling relationship (Family dynamics)\tCholinergic Drugs (neuropharmacologic agent)\tCPNE1 wt Allele (Gene or Genome)\tAbnormal shape of thyroid gland (Anatomical Abnormality)", + "output": "Cholinergic Drugs (neuropharmacologic agent)" + }, + { + "input": "Definition: Limbal dermoid described as an exceedingly rare, benign, congenital, corneal tumor characterized by bilateral opacification of the cornea with superficial grayish layers and irregular raised whitish plaques, as well as fine blood vessels covering the central cornea, and intact peripheral corneal borders. No other ocular or systemic abnormality is noted. The pattern of inheritance described in the affected family is consistent with X-linked transmission.\nConcepts: regulation of rRNA processing (Gene Expression Regulation)\tGuizar-Vazquez Luengas-Munoz syndrome (Hereditary disorder of the visual system)\tregulation of Golgi to plasma membrane protein transport (regulation of protein transport)\tsambal (Oils, Volatile)\tBathing-hygiene deficit (Self-Care Component)", + "output": "Guizar-Vazquez Luengas-Munoz syndrome (Hereditary disorder of the visual system)" + }, + { + "input": "Definition: Medical Device described as trypanosoma spp. serological reagents are devices that consist of antigens and antisera used in serological tests to identify antibodies to Trypanosoma spp. in serum. The identification aids in the diagnosis of trypanosomiasis, a disease caused by parasitic protozoans belonging to the genus Trypanosoma. Trypanosomiasis in adults is a chronic disease characterized by fever, chills, headache, and vomiting. Central nervous system involvement produces typical sleeping sickness syndrome: physical exhaustion, inability to eat, tissue wasting, and eventual death. Chagas disease, an acute form of trypanosomiasis in children, most seriously affects the central nervous system and heart muscle.\nConcepts: ENZYME LINKED IMMUNOSORBENT ASSAY, T. CRUZI (Medical Device)\tBetula, NOS (Trees and shrubs)\tExtended spectrum beta-lactamase producing Klebsiella pneumoniae (Klebsiella pneumoniae)\tFornix, Brain (Neuroanatomy)\tSubfamily Gerbillinae (Muridae)", + "output": "ENZYME LINKED IMMUNOSORBENT ASSAY, T. CRUZI (Medical Device)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.\nConcepts: measures weight (Quantitative Concept)\tDS01 (Intellectual Product)\tChlorzoxazone/Acetaminophen (Muscle Relaxant Preparation)\tpositive regulation of non-canonical Wnt signaling pathway (regulation of non-canonical Wnt signaling pathway)\tGOSE110 (GOSE Questionnaire Question)", + "output": "positive regulation of non-canonical Wnt signaling pathway (regulation of non-canonical Wnt signaling pathway)" + }, + { + "input": "Definition: Organic Chemical described as an orally bioavailable, second-generation hydroxamic acid-based inhibitor of histone deacetylase (HDAC), with potential antineoplastic activity. HDAC inhibitor VRx-3996 targets and inhibits HDAC, resulting in an accumulation of highly acetylated histones, the induction of chromatin remodeling, and the selective transcription of tumor suppressor genes; these events result in the inhibition of tumor cell division and the induction of tumor cell apoptosis. This agent may upregulate HSP70 and downregulate anti-apoptotic Bcl-2 proteins more substantially than some first-generation HDAC inhibitors. HDACs, upregulated in many tumor cell types, are a family of metalloenzymes responsible for the deacetylation of chromatin histone proteins. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78475\" active clinical trials using this agent.\nConcepts: Binocular Loupes (Loupes)\tImaging Reconstruction Protocol Element (Intellectual Product)\tArteriography (angiogram)\tVRx3996 (Pharmacologic Substance)\tGrade 4 Cerebrospinal fluid leakage (Finding)", + "output": "VRx3996 (Pharmacologic Substance)" + }, + { + "input": "Definition: Benign epithelial tumor of ovary described as a non-metastasizing neoplasm that arises from the ovary and is characterized by the presence of neoplastic epithelial cells that resemble urothelial cells.\nConcepts: seminoma (Malignant Testicular Germ Cell Tumor)\tBenign Ovarian Transitional Cell Neoplasm (Neoplastic Process)\tIRF5 wt Allele (IRF5 gene)\tT-Box 5 Gene (Gene Mutation)\tBlindness, Word (Specific learning disability)", + "output": "Benign Ovarian Transitional Cell Neoplasm (Neoplastic Process)" + }, + { + "input": "Definition: Microsurgery described as a surgical technique used primarily in the treatment of skin neoplasms, especially basal cell or squamous cell carcinoma of the skin. This procedure is a microscopically controlled excision of cutaneous tumors either after fixation in vivo or after freezing the tissue. Serial examinations of fresh tissue specimens are most frequently done.\nConcepts: Greylag goose (Anser anser)\tFAMS01-I Am Frustrated by My Condition (Intellectual Product)\tNeglect of Child (family dysfunction)\tmohs' surgery (Surgical Procedure by Method)\tPercent Predicted Maximal Inspiratory Pressure (Diagnostic Procedure)", + "output": "mohs' surgery (Surgical Procedure by Method)" + }, + { + "input": "Definition: Skin flap and skin graft operations described as grafting skin from one site to another within an individual or between individuals of the same or different species.\nConcepts: skin graft (Skin flap and skin graft operations)\tGrade 2 Testicular disorder (Testicular Disorder, CTCAE)\tLouse-borne typhus (Bacterial Infections)\tMESDC2-SENP1 Fusion Protein (Amino Acid, Peptide, or Protein)\tdesmosome disassembly (desmosome organization)", + "output": "skin graft (Skin flap and skin graft operations)" + }, + { + "input": "Definition: Unit of Catalytic Activity Concentration described as unit of catalytic activity concentration defined as activity equal to one millionth of katal per one liter of the system volume.\nConcepts: Breast Carcinoma Metastatic to the Bone (Neoplastic Process)\tregulation of mitotic spindle elongation (Cell Function)\tgenkwanin 6-hydroxylase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tMicrokatal per Liter (Unit of Catalytic Activity Concentration)\trewards (Mental Process)", + "output": "Microkatal per Liter (Unit of Catalytic Activity Concentration)" + }, + { + "input": "Definition: Conceptual Entity described as specifies whether any pregnancies resulted in miscarriages.\nConcepts: Miscarriage Indicator (Indicator)\tentry into host through natural portals (entry into host)\tPlatelet activation, function (HEMATOPOIETIC SYSTEM: GENERAL TERMS)\ttalipes (Congenital Foot Deformity)\tEyelid Carcinoma pT2a TNM Finding v8 (Finding)", + "output": "Miscarriage Indicator (Indicator)" + }, + { + "input": "Definition: something described as a chemoimmunotherapy regimen consisting of irinotecan, panitumumab and vemurafenib that can be used for the treatment of colon cancer.\nConcepts: Irinotecan/Panitumumab/Vemurafenib Regimen (Therapeutic or Preventive Procedure)\tN1 to P1 Peak to Peak Amplitude (Diagnostic Procedure)\tpositive regulation of deubiquitinase activity (Molecular Function)\tMobility of scapula (Organism Function)\tthin skin (Thickness of skin - finding)", + "output": "Irinotecan/Panitumumab/Vemurafenib Regimen (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Mixed Salivary Gland Tumor described as a malignant tumor arising from the salivary gland. It includes the following two entities: 1. carcinoma ex pleomorphic adenoma which is defined as a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and 2. carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8025\" active clinical trials using this agent.\nConcepts: Paraesthesias (Pain / sensation finding)\tphosphorylation (Metabolism)\tMalignant Salivary Gland Mixed Cell Type Neoplasm (Mixed Salivary Gland Tumor)\tAntigenic Variation (Immunogenetics)\tcell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration (Cell Function)", + "output": "Malignant Salivary Gland Mixed Cell Type Neoplasm (Mixed Salivary Gland Tumor)" + }, + { + "input": "Definition: Syndrome described as an X-linked syndrome caused by mutations in the MID1 gene or autosomal dominant syndrome caused by changes in chromosome 22. It is characterized by ocular hypertelorism, and defects of the larynx, trachea, or esophagus. Most males have hypospadias, cryptorchidism, underdeveloped scrotum, or a scrotum divided into two lobes. Mild intellectual disability and developmental delays occur in approximately half of the affected individuals.\nConcepts: pyrimidine nucleotide salvage (pyrimidine-containing compound salvage)\tCEMENT, EAR, NOSE AND THROAT (Medical Device)\tOPITZ GBBB SYNDROME, TYPE II (Disease or Syndrome)\tInternational Network of Food Data Systems (Intellectual Product)\tresponse to sodium phosphate (response to salt)", + "output": "OPITZ GBBB SYNDROME, TYPE II (Disease or Syndrome)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity Version 4 (FACT/GOG-NTX Version 4) Physical Well-Being: I am forced to spend time in bed.\nConcepts: G-Protein Subunit Alpha-11 (Amino Acid, Peptide, or Protein)\tFAC057-I Am Forced to Spend Time in Bed (Intellectual Product)\tDefined Contingent On Relationship Pause Quantity (Pause Quantity)\teCTD Supplement Effective Date Type (Intellectual Product)\tMontanide ISA 51 VG (Pharmacologic Substance)", + "output": "FAC057-I Am Forced to Spend Time in Bed (Intellectual Product)" + }, + { + "input": "Definition: Aromatase Inhibitors described as an aromatase inhibitor with a non-steroidal structure. Non-steroidal aromatase inhibitors work by reversible competition with the enzyme.\nConcepts: Preauricular (Body part)\tNon-Steroidal Estrogen Synthetase Inhibitor (Aromatase Inhibitors)\tLaminin Staining Method (Laboratory Procedure)\tUnique Subject Identifier (Subject Identifier)\tglycerol-phosphate:inorganic phosphate antiporter activity (Molecular Function)", + "output": "Non-Steroidal Estrogen Synthetase Inhibitor (Aromatase Inhibitors)" + }, + { + "input": "Definition: Procedure on face described as soft tissue manipulative technique using passively induced jaw motion to improve drainage of middle ear structures via the Eustachian tube and lymphatics.\nConcepts: NCI CTEP Simple Disease Classification Leukemia, Miscellaneous Sub-Category Terminology (Intellectual Product)\tSevere cutaneous adverse reactions (Classification)\tWell-Being Score 9 (Intellectual Product)\tMandibular drainage technique (Therapeutic or Preventive Procedure)\tpositive regulation of histone H3-K36 trimethylation (regulation of histone H3-K36 trimethylation)", + "output": "Mandibular drainage technique (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: ATOPIC AND HYPERSENSITIVITY STATES described as an allergic reaction with strong family tendencies\nConcepts: UPD1-Activities:Falling (UPDRS Questionnaire Question)\tBreast Implant Sleeves (Medical Device)\tTLR8 signaling pathway (Molecular Function)\tbeta-2 adrenergic receptor binding (Molecular Function)\tAtopic diathesis (Allergic disposition)", + "output": "Atopic diathesis (Allergic disposition)" + }, + { + "input": "Definition: something described as elongation of a fatty acid chain into which one or more C-C double bonds have been introduced.\nConcepts: Non-Sterile Vibratory Powder Filling Method (Filling Method)\tfatty acid elongation, unsaturated fatty acid (Molecular Function)\tStaining of sputum for Pneumocystis (GENERAL MICROBIOLOGY EXAMINATION, CULTURE AND STAINING PROCEDURES)\tHibernation (Behavior, Animal)\tpositive regulation of cellular amide metabolic process (positive regulation of cellular metabolic process)", + "output": "fatty acid elongation, unsaturated fatty acid (Molecular Function)" + }, + { + "input": "Definition: negative regulation of nucleobase-containing compound metabolic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving purine nucleobases.\nConcepts: Hepatitis C Virus Antigen (Laboratory Procedure)\tregulation of response to gamma-interferon (regulation of response to cytokine stimulus)\tg/min (Unit of Dose Calculation)\tCalcium Channel Inhibition (Calcium Signaling)\tnegative regulation of purine base metabolic process (negative regulation of nucleobase-containing compound metabolic process)", + "output": "negative regulation of purine base metabolic process (negative regulation of nucleobase-containing compound metabolic process)" + }, + { + "input": "Definition: Anemia, Neonatal described as a condition which occurs in monozygotic twins in which one of the fetuses supplies the majority of the cardiac output to its co-twin through its umbilical artery. The recipient twin has only rudimentary organs and structure and is not viable.\nConcepts: Third cervical vertebra (Cervical Vertebrae)\tsenile plaque (Central Nervous System)\tTwin to twin transfusion (Finding of lesion)\tTARGETED GENOME SEQUENCING (Laboratory Procedure)\tartificial intelligence (Automation)", + "output": "Twin to twin transfusion (Finding of lesion)" + }, + { + "input": "Definition: Enterobacteriaceae described as any bacteria that is not assigned to the species level but can be assigned to the Enterobacter genus level.\nConcepts: pyrroloquinoline quinone binding (vitamin binding)\tGenus Enterobacter (Bacterium)\tSecondary caries (Caries)\tComplement Component 4B (Chido Blood Group), Copy 2 wt Allele (Gene or Genome)\tClosed Colles' fracture (Closed fracture of distal end of radius)", + "output": "Genus Enterobacter (Bacterium)" + }, + { + "input": "Definition: something described as brief Pain Inventory Short Form (BPI Short Form) Circle the one number that describes how, during the past 24 hours, pain has interfered with your general activity.\nConcepts: Mannose Binding Lectins (Lectin)\tHow Often Felt Things Going Your Way (Intellectual Product)\tMatrix, Bone (Extracellular Matrix)\tpositive regulation of TGF-beta secretion (regulation of transforming growth factor-beta secretion)\tBPI Short Form - Pain Interfered with General Activity (BPI Short Form Questionnaire Question)", + "output": "BPI Short Form - Pain Interfered with General Activity (BPI Short Form Questionnaire Question)" + }, + { + "input": "Definition: Endoscopes described as specula designed for the examination of the vagina that permit a direct view of the tissues of the vagina and cervix. Colposcopes usually include an illumination system and magnifying lenses, which allow better examination of the vagina than a common vaginal specula.\nConcepts: MEGACOLON, CONGENITAL (Colonic Diseases)\tcolposcope (Microscopes)\tTunica Vasculosa (Male Reproductive System Part)\tCandidate (Property or Attribute)\txyloglucan metabolic process (hemicellulose metabolic process)", + "output": "colposcope (Microscopes)" + }, + { + "input": "Definition: something described as functional Assessment of Chronic Illness Therapy-Dyspnea Scale 33 Item Bank - Functional Limitation: Considering your shortness of breath over the past 7 days, rate the amount of difficulty you had when doing the following activities: Lifting something weighing more than 20 lbs (about 9 kg, like a medium-sized suitcase).\nConcepts: Major Group Rhinovirus Receptor (Immunologic Factor)\tIU/mL/(kg/m2) (Quantitative Concept)\tvulval cell fate specification (cell fate specification)\tFAC100-Limit: Lifting More Than 20 Lbs (Intellectual Product)\tAutosomal dominant inheritance with paternal imprinting (Cell or Molecular Dysfunction)", + "output": "FAC100-Limit: Lifting More Than 20 Lbs (Intellectual Product)" + }, + { + "input": "Definition: something described as asymptomatic; clinical or diagnostic observations only; intervention not indicated\nConcepts: participation (Interpersonal Relations)\tNucleus tangentialis (Body Part, Organ, or Organ Component)\tGrade 1 Glossopharyngeal Nerve Disorder, CTCAE (Glossopharyngeal Nerve Disorder, CTCAE)\tInterferon Alpha-Inducible Protein 6 Measurement (Protein or Enzyme Type Measurement)\tSporadic Papillary Renal Cell Carcinoma (Papillary Renal Cell Carcinoma)", + "output": "Grade 1 Glossopharyngeal Nerve Disorder, CTCAE (Glossopharyngeal Nerve Disorder, CTCAE)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss.\nConcepts: inosinate nucleosidase activity (hydrolase activity, hydrolyzing N-glycosyl compounds)\tPackaging Materials Problem (Device Evaluation Result)\tenzymes inhibitors (Molecular Function)\tcuticle hydrocarbon formation (Anabolism)\tMuscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 2 (Disease or Syndrome)", + "output": "cuticle hydrocarbon formation (Anabolism)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of glucocorticoid mediated signaling pathway.\nConcepts: TECHNICAL PROBLEMS (Problem)\tupregulation of glucocorticoid mediated signaling pathway (positive regulation of signal transduction)\tBAY-1163877 (Pharmacologic Substance)\tasexual sporulation resulting in formation of a multicellular or syncytial spore (sporulation resulting in formation of a multicellular or syncytial spore)\tFever, Marburg Hemorrhagic (Virus Diseases)", + "output": "upregulation of glucocorticoid mediated signaling pathway (positive regulation of signal transduction)" + }, + { + "input": "Definition: Psychosocial Health described as outcomes that describe an individual's relationships with others\nConcepts: Product containing medicinal gold (third transition series)\tsocial interactions (Caregiver lifestyle disruption status)\tNative (Beginning)\tPlatelet activation (Blood coagulation)\tENDOTHELIAL DIFFERENTIATION GENE 5 (Gene or Genome)", + "output": "social interactions (Caregiver lifestyle disruption status)" + }, + { + "input": "Definition: Hemangioma of skin described as a hemangioma arising from the skin of the scrotum.\nConcepts: Abnormal cellular composition of bronchoalveolar fluid (Abnormal bronchoalveolar lavage fluid morphology)\tHemangioma of Scrotum (Benign neoplasm of scrotum)\tPPH3 (Gene or Genome)\tSpecialized Program of Research Excellence (Governmental or Regulatory Activity)\tConfusional Arousals (Mental and Behavioral Signs and Symptoms)", + "output": "Hemangioma of Scrotum (Benign neoplasm of scrotum)" + }, + { + "input": "Definition: CDISC SEND Terminology described as terminology associated with the rad/nuc agent source response codelist of the Clinical Data Interchange Standards Consortium (CDISC) Standard for the Exchange of Non-clinical Data (SEND).\nConcepts: Kinked Tail (Finding)\tRNASRC (Intellectual Product)\tarea 32 of Mauss (Body Location or Region)\tHypothalamohypophysial tract (Body Part, Organ, or Organ Component)\tVoreloxin (Quinolone Antibiotic)", + "output": "RNASRC (Intellectual Product)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: H+ + isopimaradienol + NADPH + O2 <=> isopimaradiene-diol + NADP + H2O.\nConcepts: thiamine-triphosphatase activity (nucleoside triphosphatase activity)\tc-K-ras Q61H (KRAS NP 004976.2:p.Q61X)\tInterleukin 1 Receptor-Like 1 (Laboratory Procedure)\tEGFR p.R748 P753del (EGFR Protein Variant)\tisopimaradienol hydroxylase activity (Molecular Function)", + "output": "isopimaradienol hydroxylase activity (Molecular Function)" + }, + { + "input": "Definition: medical specialty by type of problem described as the branch of medicine concerned with the evaluation and initial treatment of urgent and emergent medical problems, such as those caused by accidents, trauma, sudden illness, poisoning, or disasters. Emergency medical care can be provided at the hospital or at sites outside the medical facility.\nConcepts: EMERGENCY MED (Medical Specialities)\tPersistent Left Superior Vena Cava (Abnormal superior vena cava morphology)\tBRAINSTEM NEOPL (Infratentorial Neoplasms)\tFibular tarsal bone (Tarsal Bones)\tTeacher Effectiveness Evaluation (Intellectual Product)", + "output": "EMERGENCY MED (Medical Specialities)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of gallbladder cancer, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases. There is no pathologic M0 for gallbladder cancer.\nConcepts: Locally Advanced Unresectable Renal Cell Carcinoma (Metastatic Renal Cell Carcinoma)\tGallbladder Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)\tliver structure (Body part)\tBatrachochytrium (Chytridiomycota)\tNeurofibromatosis Type 1 Gene Product (ras GTPase-Activating Proteins)", + "output": "Gallbladder Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Isoflavones described as an isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring.\nConcepts: Abnormality of tooth pulp (Finding)\tPressure Signal (Medical Device)\tPOCF (Statistical Imputation)\tVideo Monitors (Monitor Device)\t5,7,4'-trihydroxyisoflavone (Biologically Active Substance)", + "output": "5,7,4'-trihydroxyisoflavone (Biologically Active Substance)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3.0 Parent Report for Young Adults Report (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report) In the past one month, how much of a problem has this been for your child: It is hard for my child to explain his or her illness to other people.\nConcepts: PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Hard Explain Illness to People (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report Questionnaire Question)\tI enjoyed life (Findings-Based Question)\tThai (Tai language)\tGrade 2 Pharyngitis, CTCAE (Pharyngitis, CTCAE)\tPeripheral Artery Disease (Blood, Heart and Circulation)", + "output": "PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report - Hard Explain Illness to People (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Adults Report Questionnaire Question)" + }, + { + "input": "Definition: Disturbance of growth described as a non-neoplastic hamartomatous polyp that arises from the stomach and intestinal tract. It is characterized by the presence of tortuous and cystically dilated glands, edematous changes, and inflammation.\nConcepts: United States County (County)\tPODCI154 (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tJ/cm2 (Quantitative Concept)\tPOLYPS, JUVENILE (Neoplastic Process)\tBILATERAL SEQUENTIAL (Therapeutic or Preventive Procedure)", + "output": "POLYPS, JUVENILE (Neoplastic Process)" + }, + { + "input": "Definition: Disorder of tonsil described as an abscess that develops in the space surrounding one or both palatine tonsils.\nConcepts: helicobacter (Bacterium)\tquinsy (Disease or Syndrome)\tVFQ1-Difficulty Figure Out Bill Accuracy (VFQ25-Interviewer Administered Format Questionnaire Question)\tChorioallantoic Membranes (Extraembryonic membranes)\tPeriderm (Embryonic tissue)", + "output": "quinsy (Disease or Syndrome)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Version 3 Child Parent Report - In the past one month, how much of a problem has this been for your child: I think money is a problem in our family.\nConcepts: PQL0623 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)\tNEEDLE, PNEUMOPERITONEUM, SPRING LOADED (Medical Device)\tProsocial Behaviors (Social Behavior)\tGenomePlex Whole Genome Amplification (Molecular Biology Research Technique)\tBuchnera (Bacterium)", + "output": "PQL0623 (PedsQL Neuromuscular Module Version 3.0 Parent Report for Child Questionnaire Question)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.\nConcepts: Food Energy in Kilocalories (Quantitative Concept)\tprotein phosphatase 5 binding (Molecular Function)\tneurotrophin-induced neuronal synaptic plasticity (regulation of neuronal synaptic plasticity)\tGrade 3 Pharyngeal Fistula, CTCAE (Pharyngeal Fistula, CTCAE)\tCoyote (Chordata)", + "output": "neurotrophin-induced neuronal synaptic plasticity (regulation of neuronal synaptic plasticity)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2).\nConcepts: 2-keto-4-methylthiobutyrate aminotransferase activity (aminotransferase activity)\tSYRINGE, CARTRIDGE (Medical Device)\tbehavioural defense response (Organism Function)\tglutamine breakdown to fumarate, using glutaminase (glutamate catabolic process)\tBOTULINUM NEUROTOXIN A8 (botulinum toxin type A)", + "output": "glutamine breakdown to fumarate, using glutaminase (glutamate catabolic process)" + }, + { + "input": "Definition: Gastric Soft Tissue Neoplasm described as a rare glomus tumor that arises from the stomach. It is seen in adults, especially women. The majority of cases follow a benign clinical course.\nConcepts: Gastric Glomus Tumor (Gastric Soft Tissue Neoplasm)\tEmployee Salary Type (Intellectual Product)\tchromatin silencing complex location (Cell Component)\tDistal trisomy 4p (Disease or Syndrome)\tAbsent knee jerk reflex (Finding)", + "output": "Gastric Glomus Tumor (Gastric Soft Tissue Neoplasm)" + }, + { + "input": "Definition: Punch described as punches designed to excise a segment of tissue (frequently in the form of a disc) from an anatomic structure or from a donor graft during surgical procedures. These punches are typically handheld, manual instruments with a movable, sharp mechanism (e.g., tube, jaw) at the distal end operated by squeezing a ring-shaped, two-part handle. Dedicated surgical punches are available for specific anatomic structures and/or tissue, including bone, skin, blood vessels, ear, nose, and skull.\nConcepts: Gliomatosis Peritonei (Non-Neoplastic Peritoneal Disorder)\tSurgical Punches (Punch)\tHistory of trauma (ACC-AHA Measure)\ttriglyceride catabolism (acylglycerol catabolic process)\tRegio metacarpalis (Hand)", + "output": "Surgical Punches (Punch)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in the regulation of gene expression and plays a tumor suppressor role in lung, colorectal and breast carcinomas, leukemia, medulloblastoma and glioblastoma multiforme.\nConcepts: post-embryonic camera-type eye development (post-embryonic animal organ development)\tL3 Pediatric Acute Lymphocytic Leukemia (cellular diagnosis, childhood acute lymphoblastic leukemia)\tmiRNA124-1 (MicroRNA Gene)\tPinch graft of skin (Skin graft material)\tGrade 4 Neonatal Culture Negative Sepsis, AE (Neonatal Culture Negative Sepsis, Adverse Event)", + "output": "miRNA124-1 (MicroRNA Gene)" + }, + { + "input": "Definition: something described as any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.\nConcepts: Carbide Dental Burs (Medical Device)\tkilling of cells of other organism (Organism Function)\tUHDR110 (Intellectual Product)\tReproductive System (body system)\tFig Flavor (Structured Product Labeling Flavor)", + "output": "killing of cells of other organism (Organism Function)" + }, + { + "input": "Definition: Virus described as a species of HANTAVIRUS causing nephropathia epidemica, a mild form of HEMORRHAGIC FEVER WITH RENAL SYNDROME. It is found in most of Europe and especially in Finland, along with its carrier rodent, the bank vole (Clethrionomys glareolus).\nConcepts: IL-10 (cytokine binding)\tLaurus nobilis (Organic Chemical)\tF Box (Amino Acid Sequence)\tYour level of joint stiffness is (Intellectual Product)\tPuumala virus (Hantavirus)", + "output": "Puumala virus (Hantavirus)" + }, + { + "input": "Definition: something described as a unit of concentration expressed as a number of copies per unit volume equal to one microgram.\nConcepts: Bleomycin/Cyclophosphamide/Doxorubicin/Prednisolone/Vindesine Regimen (Regimen Used to Treat Hodgkin Lymphoma)\tcopies/ug (Quantitative Concept)\tRING3-Like Protein (Regulatory Protein)\tFLUOROMETRIC METHOD, TRIGLYCERIDES (Medical Device)\tMaxillary vein (Veins)", + "output": "copies/ug (Quantitative Concept)" + }, + { + "input": "Definition: something described as a non-fucosylated monoclonal antibody directed against the ephrin receptor A3 (EphA3), with potential antineoplastic activity. Upon administration, anti-EphA3 monoclonal antibody KB004 selectively binds to tumor cells expressing EphA3. This blocks both EphA3 activation and EphA3-mediated signaling, and induces apoptosis in EphA3-expressing tumor cells. In addition, KB004 can stimulate antibody dependent cell-mediated cytotoxicity (ADCC) against EphA3-expressing tumor cells. This agent also prevents tumor cell proliferation by inhibiting both EphA3 signaling and proliferation of endothelial cells in the tumor vasculature. The cell-surface receptor EphA3, a member of the ephrin family of receptor tyrosine kinases (RTKs) that are involved in mammalian development, is overexpressed by a variety of tumor types but is not expressed in normal healthy adult tissues. It plays an important role in tumor cell proliferation. Non-fucosylation of the antibody enhances its ADCC activity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C116629\" active clinical trials using this agent.\nConcepts: COXEN Score 9 (COXEN Sensitivity Scale)\tTypus Edinburgensis (Disease or Syndrome)\t13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol (progesterone)\tKB-004 (Pharmacologic Substance)\tATPase-coupled monocarboxylic acid transmembrane transporter activity (ATPase-coupled carboxylic acid transmembrane transporter activity)", + "output": "KB-004 (Pharmacologic Substance)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as centrosomal protein of 170 kDa protein B (1589 aa, ~172 kDa) is encoded by the human CEP170B gene. This protein may be involved in microtubule dynamics.\nConcepts: Toll-Like Receptor 9 wt Allele (Gene or Genome)\tTumor Regression Score 1 (Disease Grade Qualifier)\tprimary active transmembrane transporter activity (Molecular Function)\tCep170-Related (Amino Acid, Peptide, or Protein)\tPeritoneal Surface (Body Part, Organ, or Organ Component)", + "output": "Cep170-Related (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Angiotensin Converting Enzyme Inhibitor [EPC] described as the active metabolite of benazepril, a carboxyl-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Once the prodrug benazepril is metabolized to benazeprilat in the liver, benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II, resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.\nConcepts: Urinary bladder pain (Bladder finding)\tBlasts Less than 20% of Peripheral Blood White Cells (Laboratory or Test Result)\tBenzocaine [dup] (Esters of aminobenzoic acid for local anesthesia)\tBENAZEPRILAT (B [Preparations])\theart valve formation (anatomical structure formation involved in morphogenesis)", + "output": "BENAZEPRILAT (B [Preparations])" + }, + { + "input": "Definition: Quantitative Concept described as a number representing the outer diameter of a needle.\nConcepts: Dialpack (Dose Pack)\tCNBD1 (Gene or Genome)\tMad2 Mitotic Arrest Deficient-like 1 Proteins (Amino Acid, Peptide, or Protein)\tNeedle Gauge (size)\tCorvus (Bird)", + "output": "Needle Gauge (size)" + }, + { + "input": "Definition: SUBCLASS SPIROCHETES described as a genus of Gram-negative, aerobic, flexible, spiral-shaped, spirochete with internal flagella in the phylum Spirochaetes.\nConcepts: DAVID (deficiency in anterior pituitary function, variable immunodeficiency) syndrome (Hypopituitarism)\tDermatophagoides pteronyssinus Antigen IgG Antibody Measurement (Laboratory Procedure)\tIncreased urinary sedoheptulose (Finding)\tLeptospira, NOS (BACTERIA AND RICKETTSIAE)\tFused outermost and middle bones of ring finger (Symphalangism of middle phalanx of 4th finger)", + "output": "Leptospira, NOS (BACTERIA AND RICKETTSIAE)" + }, + { + "input": "Definition: something described as the process in which a relatively unspecialized cell acquires specialized features of an epithelial cell in the urothelium. The urothelium is the epithelial tube of the ureter.\nConcepts: Grade 2 Urostomy Site Bleeding, CTCAE (Urostomy Site Bleeding, CTCAE)\tPerformed Histopathology Result (Finding)\tureter epithelial cell differentiation (Cell Function)\t2-butanone oxidase activity (Molecular Function)\thSiah2 (SIAH2 gene)", + "output": "ureter epithelial cell differentiation (Cell Function)" + }, + { + "input": "Definition: Biologically Active Substance described as the smallest of the three prokaryotic initiation factors with a molecular size of approximately 8 kD. It binds near the A-site of the 30S subunit of RIBOSOMES and may play a role in preventing premature addition of aminoacyl-tRNA-linked PEPTIDE ELONGATION FACTOR TU to the ribosome during the initiation of a peptide chain (PEPTIDE CHAIN INITIATION, TRANSLATIONAL).\nConcepts: BGJ-398 (Pharmacologic Substance)\tnegative regulation of class switch recombination to IgG isotypes (negative regulation of isotype switching)\tIL18BPa (IL18BP gene)\tMilliliter/kilogram/hour (Volume per unit mass per unit time)\tInitiation Factor IF 1 (Biologically Active Substance)", + "output": "Initiation Factor IF 1 (Biologically Active Substance)" + }, + { + "input": "Definition: Social Behavior described as the function of directing or controlling the actions or attitudes of an individual or group with more or less willing acquiescence of the followers.\nConcepts: CD38-targeting Agent (Targeted Therapy Agent)\tContracture of the distal interphalangeal joint of the 2nd finger (Flexion contracture of the 2nd finger)\tnegative regulation of stomatal complex development (negative regulation of post-embryonic development)\tleadership (Personnel Management & Professional Personnel Issues)\tFilm Digitizers (Medical Device)", + "output": "leadership (Personnel Management & Professional Personnel Issues)" + }, + { + "input": "Definition: Chromosome band described as part of the chromosome bands present on the long (q) arm of chromosome 2.\nConcepts: Blood Grouping Systems, Automated (Analyzers, Laboratory, Hematology, Blood Grouping)\t3rd trimester (Patient currently pregnant)\tNumber of Points for Lambda z (Quantitative Concept)\t2q31.2 (Cell Component)\tBody (record container)", + "output": "2q31.2 (Cell Component)" + }, + { + "input": "Definition: Classification described as excavated\nConcepts: Gamete, Plant (Plant)\ttrans-Methyl-CCNU (Pharmacologic Substance)\t9H-Fluoren-9-one, 2,7-bis(2-(diethylamino)ethoxy)- (Fluorenes)\tType 0-III (Classification)\tNeural crest head mesenchyme (Embryonic Structure)", + "output": "Type 0-III (Classification)" + }, + { + "input": "Definition: Vital signs described as a pulse that beats at irregular intervals.\nConcepts: Hemeralopias (Disease or Syndrome)\tAllorhythmic pulse (Vital signs)\tRadial Keratotomies (Surgical ocular refractive procedure)\tCommunication disorder NOS (Negative Diagnosis And Outcome)\tNervous System, Ear (Body Part, Organ, or Organ Component)", + "output": "Allorhythmic pulse (Vital signs)" + }, + { + "input": "Definition: Eutheria described as an order of wholly aquatic MAMMALS occurring in all the OCEANS and adjoining seas of the world, as well as in certain river systems. They feed generally on FISHES, cephalopods, and crustaceans. Most are gregarious and most have a relatively long period of parental care and maturation. Included are DOLPHINS; PORPOISES; and WHALES.\nConcepts: PSN (Nodule Consistency)\tHumanism, NOS (Spiritual or religious belief)\tadenocarcinoma of the prostate (Malignant neoplasm of prostate)\tcetaceans (Eutheria)\tBEBQ Retrospective Version (Intellectual Product)", + "output": "cetaceans (Eutheria)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Erysipelothrix rhusiopathiae.\nConcepts: Ophthalmic Implants, Retina (Ophthalmological implant)\tpositive regulation of nuclear cell cycle DNA replication (positive regulation of DNA-dependent DNA replication)\tCRYSTALLURIA (Finding)\tAutoimmune necrotising myopathy (Autoimmune inflammation of skeletal muscle)\tBacillus insidiosus (Erysipelothrix)", + "output": "Bacillus insidiosus (Erysipelothrix)" + }, + { + "input": "Definition: Neoplastic Process described as a term that refers to the staging of prostate carcinoma according to the Whitmore-Jewett staging system.\nConcepts: Prostate Cancer by Jewett Stage (Prostate carcinoma)\tMultifocal epithelial hyperplasia (Oral lesion)\t4,4'-Tetramethyldiaminodiphenylmethane (Organic Chemical)\tEpisodic ataxia type 7 (Cerebellar Ataxia)\tAnterior innominate rotation (Innominate rotation)", + "output": "Prostate Cancer by Jewett Stage (Prostate carcinoma)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Children's Baseline (C-SSRS Children's Baseline) Have you ever decided how or when you would make yourself not alive anymore/kill yourself? Have you ever planned out (worked out the details of) how you would do it? What was your plan? When you made this plan (or worked out these details), was any part of you thinking about actually doing it?\nConcepts: S300-II (Transcription Factors, General)\tVaginal Intraepithelial Neoplasia (Intellectual Product)\tHIV1MONA (Human immunodeficiency virus test)\tC-SSRS Children's Baseline - Active Suicidal Ideation with Specific Plan and Intent (Intellectual Product)\trifamycin-B-oxidase activity (Molecular Function)", + "output": "C-SSRS Children's Baseline - Active Suicidal Ideation with Specific Plan and Intent (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the category of the result as distinguished by anatomical or physiological system, etiology, or purpose EXAMPLE(S): Blood and lymphatic system disorders; Cardiac disorders; Congenital, familial and genetic disorders; Ear and labyrinth disorders; Endocrine disorders; Eye disorders; Gastrointestinal disorders; General disorders and administration site conditions; Hepatobiliary disorders; Immune system disorders; Infections and infestations; Injury, poisoning and procedural complications; Investigations; Metabolism and nutrition disorders; Musculoskeletal and connective tissue disorders; Neoplasms benign, malignant and unspecified (incl cysts and polyps); Nervous system disorders; Pregnancy, puerperium and perinatal conditions; Psychiatric disorders; Renal and urinary disorders; Reproductive system and breast disorders; Respiratory, thoracic and mediastinal disorders; Skin and subcutaneous tissue disorders; Social circumstances; Surgical and medical procedures; Vascular disorders OTHER NAME(S): Body System System Organ Class High Level Term High Level Group Term Low Level Term NOTE(S): Examples provided here are from the values for MedDRA System Organ Class.\nConcepts: Relapsed HER2 Negative Breast Carcinoma (Neoplastic Process)\tDaily Recommended Allowance (Intellectual Product)\tNPI - He/She is in Danger (Intellectual Product)\tResultClassification.code (Intellectual Product)\tMalignant Ovarian Sex Cord-Stromal Neoplasm (Neoplastic Process)", + "output": "ResultClassification.code (Intellectual Product)" + }, + { + "input": "Definition: something described as chemical, biochemical and/or electrochemical actions causing the degradation of the hard tissue of the tooth.\nConcepts: TYPE 5 MYOCARDIAL INFARCTION (Disease or Syndrome)\tCarcinoma, Ehrlich Tumor (Undifferentiated carcinoma)\tBacillus typhi (S [Preparations])\tBiocorrosion of tooth (Disease or Syndrome)\tLipid rescue therapy (Therapeutic or Preventive Procedure)", + "output": "Biocorrosion of tooth (Disease or Syndrome)" + }, + { + "input": "Definition: Tunica Intima described as the innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.\nConcepts: intima vascular (Tunica Intima)\tAnti-nuclear antibody positive (Immunology)\tParacentesis NOS (Aspiration-action)\tFluorine F 18-fluoroazomycin Arabinoside (Indicator, Reagent, or Diagnostic Aid)\tdown regulation of type III restriction endodeoxyribonuclease activity (negative regulation of restriction endodeoxyribonuclease activity)", + "output": "intima vascular (Tunica Intima)" + }, + { + "input": "Definition: Immune response described as renewed rapid production of an antibody on the second (or subsequent) encounter with the same antigen.\nConcepts: Neonatal electro-clinical seizure with behaviour arrest (Neonatal electro-clinical non-motor seizure)\tanamnesis (Organ or Tissue Function)\tRibes nigrum L. Juice (Juice)\tShortness of Breath Score 3 (Intellectual Product)\tdemethylmacrocin methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)", + "output": "anamnesis (Organ or Tissue Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin.\nConcepts: peptidyl-cysteine acetylation (Molecular Function)\tenucleate red blood cell differentiation (Erythropoiesis)\tGroup IB Phospholipase A2 (Amino Acid, Peptide, or Protein)\tFamilial adrenal hypoplasia miniature type (Finding of hormone level)\tarsenate reductase (thioredoxin) activity (Molecular Function)", + "output": "arsenate reductase (thioredoxin) activity (Molecular Function)" + }, + { + "input": "Definition: T [Preparations] described as an eight-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males.\nConcepts: Combined immunodeficiency due to Zeta-chain associated protein kinase 70 deficiency (Autosomal recessive SCID)\tTestosterone cipionate (Organic Chemical)\testablishment of protein localization in mitochondrial membrane (establishment of protein localization to membrane)\tneuronal dense core vesicle membrane (dense core granule membrane)\tPunding (Mental or Behavioral Dysfunction)", + "output": "Testosterone cipionate (Organic Chemical)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the CD40LG gene.\nConcepts: Supporting Cell of the Nervous System (Cell)\tfull (Behavior descriptors)\thCD40L Gene Mutation (Cell or Molecular Dysfunction)\tirRECIST Stable Disease (Immune-related Response Evaluation Criteria In Solid Tumors)\tNPI - Gained Weight (NPI Questionnaire Question)", + "output": "hCD40L Gene Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: something described as a population of cytotoxic T lymphocytes (CTLs) specifically reactive to cytomegalovirus (CMV), Epstein-Barr virus (EBV), adenovirus (ADV) and BK virus (BKV), with potential antiviral and protective activities. T cells derived from peripheral blood mononuclear cells (PBMCs) are exposed to and activated by dendritic cells (DCs) that are loaded with specific peptides from CMV, EBV, ADV and BKV. Upon infusion of the CMV/EBV/ADV/BKV-specific CTLs, these lymphocytes target and cause lysis of CMV-, EBV-, ADV- and/or BKV-infected cells and may prevent infection and complications from CMV-, EBV-, ADV- and BKV-driven viral diseases. Opportunistic infections caused by these viruses are often seen in immunosuppressed patients.\nConcepts: Chronic Cancer Pain (Sign or Symptom)\tCMV/EBV/ADV/BKV specific Cytotoxic T-lymphocytes (Cell)\tBlocking Antibody (Antibody by function)\tOvine hyaluronidase product (hyaluronidase)\tcadherin (Amino Acid, Peptide, or Protein)", + "output": "CMV/EBV/ADV/BKV specific Cytotoxic T-lymphocytes (Cell)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as mapping the practitioner type or specialty to ordering laboratory procedures. Use CPT(TM) codes to bill for laboratory procedure orders. Service is billed as a no-charge item.\nConcepts: Laboratory procedure order no charge (Therapeutic or Preventive Procedure)\tTitanium Dioxide/Zinc Oxide Sunscreen (Substance)\tglucan metabolic process (polysaccharide metabolic process)\tchlorogenic acid esterase activity (carboxylic ester hydrolase activity)\tPublic health (Medicine)", + "output": "Laboratory procedure order no charge (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Finding described as oropharyngeal (p16-negative) cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).\nConcepts: Differentiation of familiar persons (Social Behavior)\tIntersulcal connective tissue of fibrous ring of tricuspid valve (Subdivision of fibrous skeleton of heart)\tOropharyngeal (p16-Negative) Carcinoma cN2c TNM Finding v8 (Finding)\tPain Score 9 (Finding)\tEncephalomyelitis Infection, CTCAE (Finding)", + "output": "Oropharyngeal (p16-Negative) Carcinoma cN2c TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as stage 0a includes: Ta, N0, M0. Ta: Papillary noninvasive carcinoma. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: CDISC Questionnaire PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Test Code Terminology (Intellectual Product)\tKidney Bean Lectin (Plant Proteins)\tStage 0a Renal Pelvis and Ureter Urothelial Carcinoma AJCC v7 (Stage 0 Renal Pelvis and Ureter Cancer AJCC v7)\tdetection early (Diagnostic Procedure)\tOphthalmic Biopsy Brushes (Medical Device)", + "output": "Stage 0a Renal Pelvis and Ureter Urothelial Carcinoma AJCC v7 (Stage 0 Renal Pelvis and Ureter Cancer AJCC v7)" + }, + { + "input": "Definition: something described as any abnormality of the proximal epiphysis of the humerus.\nConcepts: Abnormality of the proximal humeral epiphysis (Anatomical Abnormality)\tGrade 3 Bladder anastomotic leak (Finding)\tHORIZONTAL TRANSMISSION (disease transmission)\tDyslipidaemia (Classification)\tPercent Predicted Inspiratory Reserve Volume (Pulmonary function tests)", + "output": "Abnormality of the proximal humeral epiphysis (Anatomical Abnormality)" + }, + { + "input": "Definition: Medical Device described as cavity lining dental solutions designed for use as a very thin protective coating over the surfaces of a dental cavity before placement of restorative materials. These dental materials consist of clear solutions of a resinous material or natural gum in a suitable organic solvent (e.g., ether or chloroform), that quickly evaporate and leave the resin as a very thin film over the preparation. Cavity varnish is not intended for use with composite resins since the varnish retards their set and interferes with their bonding. They are used in dentists' offices during operative dental procedures primarily to seal the dentinal tubules and to help prevent seepage of fluids, microorganisms, and/or debris between a restoration and the cavity walls (i.e., microleakage).\nConcepts: Congenital Ileal Atresia (Atresia of small intestine)\tDental Materials, Cavity Varnish (Medical Device)\tPoultice (Semi-solid dose form)\tCa heparin (Anticoagulants)\tSevere trauma other than a fall (Finding)", + "output": "Dental Materials, Cavity Varnish (Medical Device)" + }, + { + "input": "Definition: B-Cell Non-Hodgkin Lymphoma by Ann Arbor Stage described as an anatomic stage for follicular lymphoma based on the Ann Arbor classification criteria.\nConcepts: gamma-LPH (Amino Acid, Peptide, or Protein)\tExtra little finger (Congenital Abnormality)\tFollicular Lymphoma by Ann Arbor Stage (Lymphoma, Follicular)\tCollagen Fiber (Fibrillar component of intercellular matrix)\tSodium Glucose Cotransporter 1 (Sodium-Glucose Transport Proteins)", + "output": "Follicular Lymphoma by Ann Arbor Stage (Lymphoma, Follicular)" + }, + { + "input": "Definition: Bone structure of distal tibia described as zone of tibia, each instance of which is a process on the medial side of some tibia.\nConcepts: Burning Waste Smoke Exposure (Finding)\tmin*pmol/mL (Measurement Unit Description)\tMM - Medial malleolus (Prominence)\tNeonatal Lesion (Finding)\tstapes (Body Part, Organ, or Organ Component)", + "output": "MM - Medial malleolus (Prominence)" + }, + { + "input": "Definition: peptidoglycan muralytic activity described as catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan.\nConcepts: N,O-diacetylmuramidase activity (Molecular Function)\ttryptophanyl-tRNA aminoacylation (tRNA aminoacylation for protein translation)\tMyosin Type IIB, Non Muscle (Amino Acid, Peptide, or Protein)\textrinsic component of matrix side of mitochondrial inner membrane (Cell Component)\tIVD Test Reagent/Kits, Home Assay, Urine, pH (Medical Device)", + "output": "N,O-diacetylmuramidase activity (Molecular Function)" + }, + { + "input": "Definition: something described as a measurement of the efficiency of coagulation of a biological specimen. This is calculated by a mathematical formula that takes into account the R value, K value, angle and maximum amplitude of clot formation.\nConcepts: Coagulation Index Measurement (Blood coagulation tests)\tmetastatic (Complication Aspects)\tChlorination (Biochemical Processes)\tTaftsin (Immunologic Factor)\tIPAF inflammasome complex (inflammasome complex)", + "output": "Coagulation Index Measurement (Blood coagulation tests)" + }, + { + "input": "Definition: Oligosaccharides described as oligosaccharides containing various types of glycosidic linkages that yield branching or antennae. The number of antennae (such as bi-, tri-, tetra-, or penta-antennary) in the oligosaccharides on the PROTEOGLYCANS; GLYCOPROTEINS; or LIPOPOLYSACCHARIDES contribute to their biological activities, such as receptor binding and metabolism.\nConcepts: Osteomesopycnosis (Spinal Diseases)\tHNPCC1 Protein (Adenosine Triphosphatases)\tNitrosations (Biochemical Phenomena)\tBranched-Chain Oligosaccharides (Oligosaccharides)\tUBIQUITIN-SPECIFIC PROTEASE 18 (Cysteine Protease Genes)", + "output": "Branched-Chain Oligosaccharides (Oligosaccharides)" + }, + { + "input": "Definition: something described as the EuroQol (European Quality of Life) Five Dimension Five Level Scale (EQ-5D-5L) Mark an X on the scale to indicate how your health is today and write the number you marked on the scale in the box below.\nConcepts: Anterior semilunar fibrous scallop of aortic valve anulus (Body Part, Organ, or Organ Component)\tCHART, VISUAL ACUITY (Ophthalmic examination and evaluation)\tBMI < 19 (Finding)\tterpenoid biosynthetic process, mevalonate-dependent (Terpenoid Biosynthesis Pathway)\tEQ5D0206 (Intellectual Product)", + "output": "EQ5D0206 (Intellectual Product)" + }, + { + "input": "Definition: mucosal tolerance induction described as tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT).\nConcepts: IIEF Questionnaire Question (Intellectual Product)\tTsukamurella aichiensis (Rhodococcus)\tSUBLINGUAL (Administration, Oral)\ttolerance induction in mucosal-associated lymphoid tissue (mucosal tolerance induction)\tDRRI1G09 (Intellectual Product)", + "output": "tolerance induction in mucosal-associated lymphoid tissue (mucosal tolerance induction)" + }, + { + "input": "Definition: Gene Expression Regulation described as any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.\nConcepts: insulin-like growth factors (Endocrine system)\tglutamate synthesis (Molecular Function)\tDeleterious FAA Gene Mutation (FANCA Gene Mutation)\tGENE EXPRESSION REG FUNGAL (Gene Expression Regulation)\tPSA Decline 25 Percent or Greater (PSA Level Finding)", + "output": "GENE EXPRESSION REG FUNGAL (Gene Expression Regulation)" + }, + { + "input": "Definition: something described as the explanation given as to why microbiology susceptibility was not assessed.\nConcepts: ENDOSCOPE, FIBER OPTIC (Medical Device)\tFAC04208 (NCCN-FACT FKSI-19 Version 2 Questionnaire Question)\tSquamous Metaplasia (Cell or Molecular Dysfunction)\tMicrobiology Susceptibility Reason Not Done (Not-Done Reason)\tGroup, Focus (Groups)", + "output": "Microbiology Susceptibility Reason Not Done (Not-Done Reason)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.\nConcepts: community dental health (Biomedical Occupation or Discipline)\tcholinergic synapse (Synapses)\tHimalaya ProSelect(TM) Prostane 100 (Nutraceuticals)\tScratching (Action)\tprostate development (Organ or Tissue Function)", + "output": "prostate development (Organ or Tissue Function)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Mitochondrial Disorder described as molecular assay reagents intended to identify genetic variants associated with MERRF/MELAS overlap syndrome, a mitochondrial disorder exhibiting signs and symptoms characteristic of both mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) and myoclonic epilepsy with ragged-red fibers (MERRF). Genetic variants at multiple loci have been associated with MERRF/MELAS overlap syndrome. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple MERRF/MELAS overlap syndrome-associated loci simultaneously.\nConcepts: IVD Panels, Human Genetics, Mitochondrial Disorder, MERRF/MELAS Overlap Syndrome (Medical Device)\tMedian Ventricular Rate by Electrocardiogram (ECG Measurement)\tCHYMOTRYPSIN C (Peptidase Gene)\tTransducers, Pressure, Vascular Aneurysm, Ultrasound (Transducers, Pressure, Vascular Aneurysm)\tImaging Sub-Domain (Intellectual Product)", + "output": "IVD Panels, Human Genetics, Mitochondrial Disorder, MERRF/MELAS Overlap Syndrome (Medical Device)" + }, + { + "input": "Definition: Neoplastic Process described as plasma cell myeloma with beta-2-microglobulin less than 3.5 and albumin greater than or equal to 3.5 (median survival of 62 months). Note that the older Durie/Salmon staging system defines stage I quite differently.\nConcepts: APPARATUS, CAUTERY, RADIOFREQUENCY, AC-POWERED (Medical Device)\tInternational Staging System Stage I Multiple Myeloma (Neoplastic Process)\tLung Cancer pM1 TNM Finding v7 (Lung Cancer Pathologic Distant Metastasis TNM Finding v7)\tEricale (Magnoliopsida)\tMilnacipranum (M [Preparations])", + "output": "International Staging System Stage I Multiple Myeloma (Neoplastic Process)" + }, + { + "input": "Definition: COUGH AND COLD PREPARATIONS described as d-isomer of the codeine analog of levorphanol; dextromethorphan shows high affinity binding to several regions of the brain, including the medullary cough center; this compound is an NMDA receptor antagonist (n-methyl-d-aspartate receptors) and acts as a noncompetitive channel blocker; it is one of the widely used antitussives, and is also used to study the involvement of glutamate receptors in neurotoxicity.\nConcepts: inflammation; pericardium (cardiac inflammation or infection)\teCTD Submission Sub-Type (Intellectual Product)\tTAF2G (Biologically Active Substance)\tDextromethorphanum (Adjuvant Analgesic)\tregulation of histone H3-K79 methylation (Molecular Function)", + "output": "Dextromethorphanum (Adjuvant Analgesic)" + }, + { + "input": "Definition: Mastectomy described as radical mastectomy with removal of the ipsilateral half of the sternum and a portion of ribs two through five with the underlying pleura and the internal mammary lymph nodes.\nConcepts: Concomitant and Prior Medications Supplemental Qualifiers Dataset (Intellectual Product)\tendoproteinase inhibitor (Molecular Function)\tRadical Mastectomies, Extended (Halsted Mastectomy)\tJunctional rhythm (Cardiac rhythm AND/OR rate finding)\tInhibiting Protein, Liver-Enriched (Amino Acid, Peptide, or Protein)", + "output": "Radical Mastectomies, Extended (Halsted Mastectomy)" + }, + { + "input": "Definition: Organic Chemical described as alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.\nConcepts: Benzyl Alcohols (Benzyl Compounds)\tUreter Endoscopes (Endoscopes)\tMycobacterium mucogenicum Springer et al. 1995 (Nontuberculous Mycobacteria)\tExtraordinary Opportunity: Preclinical Models of Cancer (Extraordinary Opportunities for Investment)\tInjection solution (Biomedical or Dental Material)", + "output": "Benzyl Alcohols (Benzyl Compounds)" + }, + { + "input": "Definition: Disorder of the genitourinary system described as a non-neoplastic or neoplastic disorder that affects the male or female genital system. Representative examples of non-neoplastic disorders include infection, testicular torsion, endometriosis, and adenomyosis. Representative examples of neoplastic disorders include germ cell tumors, carcinoma, lymphoma, and sarcoma.\nConcepts: Very poor (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, F9 (Medical Device)\tPCL0104 (Intellectual Product)\tgenital disorder (Disease or Syndrome)\tlateral zone of cerebellum (Body Part, Organ, or Organ Component)", + "output": "genital disorder (Disease or Syndrome)" + }, + { + "input": "Definition: response to electrical stimulus described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile.\nConcepts: Lymphocyte Antigen 6 Family Member E (Protein or Enzyme Type Measurement)\tSaccular diverticulum (Gastrointestinal tract finding)\tVentricular preexcitation with multiple accessory pathways (Finding)\tresponse to immobilization stress combined with electrical stimulus (response to immobilization stress)\tOral Antioxidant Solution (Chemopreventive Agent)", + "output": "response to immobilization stress combined with electrical stimulus (response to immobilization stress)" + }, + { + "input": "Definition: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Teen Questionnaire Question described as pediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report - In the past 7 days, how much of a problem has this been for your teen: My child does not have the equipment he or she needs.\nConcepts: positive regulation of cell proliferation involved in heart morphogenesis (Cell Function)\tWhite Fiber (Skeletal Myocytes)\tC Reactive Protein (Protein analyses NEC)\tPQL13-Do Not Have Equipment Need (Intellectual Product)\tGrade 3 Vasovagal Reaction, CTCAE (Finding)", + "output": "PQL13-Do Not Have Equipment Need (Intellectual Product)" + }, + { + "input": "Definition: something described as an indication that PDGFRA mutation analysis was not performed during the study.\nConcepts: precancerous (Disease Morphology Qualifier)\tGlobal Alignment of Immunization safety Assessment in pregnancy Congenital Microcephaly Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)\tnegative regulation of microtubule polymerization or depolymerization (regulation of microtubule polymerization or depolymerization)\tOral Reconstituted Suspension (Biomedical or Dental Material)\tPDGFRA Mutation Analysis Was Not Performed (Finding)", + "output": "PDGFRA Mutation Analysis Was Not Performed (Finding)" + }, + { + "input": "Definition: something described as a branch of dentistry dealing with diseases of the oral and paraoral structures and the oral management of systemic diseases.\nConcepts: Fishing and Hunting Workers (Farming, Fishing, and Forestry Occupations)\tRegulator, Calcium-Dependent (Calcium-Binding Proteins)\tPressure half time (Temporal Concept)\tStomatology (Dentistry)\tHow much bloating did you feel because of constipation (Clinical or Research Assessment Question)", + "output": "Stomatology (Dentistry)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of nerve cell cluster or a group of nerve cell bodies located in the peripheral autonomic nervous system.\nConcepts: Berlin-Frankfurt-Munster Study Group (Health Care Related Organization)\tNanoscale Phenomena (Phenomenon or Process)\t10q25.1 (Cell Component)\tAbnormality of ganglion of peripheral nervous system (Anatomical Abnormality)\tAnalysis Subcategory (Intellectual Product)", + "output": "Abnormality of ganglion of peripheral nervous system (Anatomical Abnormality)" + }, + { + "input": "Definition: Abnormality of the epiphyses of the hallux described as the presence of abnormal punctate (speckled, dot-like) calcifications in the epiphyses of the hallux.\nConcepts: H4/RET FUSION GENE (Fusion Gene)\tSpeckled calcifications in the end part of the big toe bone (Epiphyseal stippling of toe phalanges)\tChief Complaint Present in the Evening (Finding)\tof ovulation induction (Fertility and fertilisation interventions female)\tRubidium (Metals, Heavy)", + "output": "Speckled calcifications in the end part of the big toe bone (Epiphyseal stippling of toe phalanges)" + }, + { + "input": "Definition: positive regulation by organism of nutrient release from other organism involved in symbiotic interaction described as any process in which an organism activates, maintains or increases the frequency, rate or extent of the release of nutrients from its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Grade 3 Nystagmus (Nystagmus, CTCAE 5.0)\tFixed Loop Instruments, Surgical, Cardiovascular Occlusion (Fixed Loop Instruments)\tSeborrhoeic dermatitis, unspecified (Dermatitis)\tCapmatinib Hydrochloride (Pharmacologic Substance)\tup regulation by symbiont of nutrient release from host (positive regulation by organism of nutrient release from other organism involved in symbiotic interaction)", + "output": "up regulation by symbiont of nutrient release from host (positive regulation by organism of nutrient release from other organism involved in symbiotic interaction)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues.\nConcepts: Grade 4 Asystole (Finding)\tEmulsion Dosage Form (Biomedical or Dental Material)\tganglioside degradation (ganglioside metabolic process)\tIsoetarine (Selective beta-2-adrenoreceptor agonists, systemic)\tFucose, Guanosine Diphosphate (Biologically Active Substance)", + "output": "ganglioside degradation (ganglioside metabolic process)" + }, + { + "input": "Definition: something described as collection of preserved web pages.\nConcepts: NCCN-FACT FHNSI-22 Version 2 - Had Change in the Way Food Tastes (NCCN-FACT FHNSI-22 Version 2 Questionnaire Question)\tWeb Archives (Intellectual Product)\ttebipenem pivoxil (Carbapenems)\tparasitophorous vacuole (extracellular membrane-bounded organelle)\tAlmost Always Disagree (Disagree)", + "output": "Web Archives (Intellectual Product)" + }, + { + "input": "Definition: ANTINEOPLASTIC,OTHER described as an orally available co-packaged agent combination of ribociclib, a cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6, and letrozole, a nonsteroidal inhibitor of estrogen synthesis, with antineoplastic activity. Ribociclib specifically inhibits CDK4 and CDK6, thereby inhibiting retinoblastoma (Rb) phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Letrozole selectively and reversibly inhibits aromatase, which may result in growth inhibition of estrogen-dependent cancer cells.\nConcepts: Filtration Systems, Semen (Medical Device)\tRibociclib/Letrozole (Organic Chemical)\tIVD Test Reagent/Kits, Clinical Chemistry, Electrolyte, Chloride (IVD Test Reagent/Kits, Clinical Chemistry, Electrolyte)\tCutaneous Neuroendocrine Carcinoma Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)\tDrug Testing/Development, Preclinical (Research Activity)", + "output": "Ribociclib/Letrozole (Organic Chemical)" + }, + { + "input": "Definition: something described as a non-invasive, papillary epithelial neoplasm that arises from the epithelium of the gallbladder. Intraepithelial neoplasia is present.\nConcepts: Household Management (Management procedure)\tbenign papillomatosis of gallbladder (Papillary Epithelial Neoplasm)\t1q22 (Chromosome band)\tMonogenic Diabetes (Diabetes mellitus)\tLVI 1 (Cancer TNM Vessel Invasion Finding Category)", + "output": "benign papillomatosis of gallbladder (Papillary Epithelial Neoplasm)" + }, + { + "input": "Definition: Curved middle phalanges of the hand described as curved appearance of the middle phalanx of the 5th finger.\nConcepts: Instrument Lubricants (Device Labeled for Single Use)\tCurved middle bone of pinkie finger (Abnormality of the middle phalanx of the 5th finger)\tMETATARSALGIA (Sign or Symptom)\tWere you restricted in the types of food you can eat as a result of your disease or treatment (Intellectual Product)\tnegative regulation of Ca2+-transporting ATPase activity (regulation of ATPase-coupled calcium transmembrane transporter activity)", + "output": "Curved middle bone of pinkie finger (Abnormality of the middle phalanx of the 5th finger)" + }, + { + "input": "Definition: Mesothelioma malignant advanced described as cancer has spread to the chest wall, mediastinum, heart, lining of the peritoneum, and/or beyond the diaphragm. Cancer may also have spread to lymph nodes on the other side of the chest or outside the chest. Stage III malignant mesothelioma is advanced malignant mesothelioma.\nConcepts: Membrane Metalloendopeptidase Negative (Laboratory or Test Result)\tStage III Pleural Malignant Mesothelioma AJCC v7 (Mesothelioma malignant advanced)\tVulvar Porocarcinoma (Eccrine porocarcinoma)\timidazoleacetic monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tDouble Walled Nanotube (Nanotubes, Carbon)", + "output": "Stage III Pleural Malignant Mesothelioma AJCC v7 (Mesothelioma malignant advanced)" + }, + { + "input": "Definition: Adjudication described as used for the system, discipline, or the actual process itself.\nConcepts: Single-dose container (Manufactured Object)\tCoral (Eukaryote)\tUrinary Incontinence Stimulator Programmer/Testers (Medical Device)\tcriminal justice (Justice)\tregulation of planar cell polarity pathway involved in heart morphogenesis (Molecular Function)", + "output": "criminal justice (Justice)" + }, + { + "input": "Definition: Intellectual Product described as expanded Disability Rating Scale - Postacute Interview Caregiver Version - How certain are you that [name] can be successful at work, school or in home management but with limited choices in jobs or school courses due to disabilities?\nConcepts: ED1-Successful With Limited Choices (Intellectual Product)\tPseudoepiphysis of the middle phalanx of the 2nd finger (Pseudoepiphyses of the middle phalanges of the hand)\tdevelopmental genetics (Developmental Biology)\tPHQ0304C (PHQ Screener Version Questionnaire Question)\tDecreased folic acid diet (Folic acid modified diet)", + "output": "ED1-Successful With Limited Choices (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as terminology relevant to the intended disease outcome for which the treatment is given.\nConcepts: SDTM-TRTINTNT (CDISC SDTM Terminology)\tExostoses (Multiple)-Like 3 wt Allele (EXTL3 gene)\tEndosinusial Solution Dosage Form (Nasal dosage form)\tTranslocations, Genetic (Chromosome Aberrations)\tEubacterium ventriosum (Tissier 1908) Prevot 1938 (Bacterium)", + "output": "SDTM-TRTINTNT (CDISC SDTM Terminology)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a ubiquitous target SNARE protein that interacts with SYNTAXIN and SYNAPTOBREVIN. It is a core component of the machinery for intracellular MEMBRANE FUSION. The sequence contains 2 SNARE domains, one is the prototype for the Qb-SNARES, and the other is the prototype for the Qc-SNARES.\nConcepts: cicuta maculata/spotted cowb (Pharmacologic Substance)\tSynaptosomal Associated Protein 25 (Amino Acid, Peptide, or Protein)\t(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity (Molecular Function)\tSGRQ Past 4 Weeks Version - How Many Good Days You Had (Intellectual Product)\trenal regulation of systemic arterial blood pressure (renal system process)", + "output": "Synaptosomal Associated Protein 25 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Bridged-Ring Compounds described as a tricyclo bridged hydrocarbon.\nConcepts: Analysis Metadata (Metadata)\tSilver Birch Pollen IgG Antibody RAST Score Measurement (Laboratory Procedure)\tFocal aware pedal automatism seizure (Focal aware automatism seizure)\tadamantane (Bridged-Ring Compounds)\tDNA-Binding Protein (Proteins)", + "output": "adamantane (Bridged-Ring Compounds)" + }, + { + "input": "Definition: Mineral supplementation described as providing copper based on suboptimal food or fluid intake, iatrogenic deficiency or medical diagnosis.\nConcepts: Uterine Corpus Carcinoma and Carcinosarcoma FIGO Stage IVB (Finding)\tEnd of Planned Treatment (Not-Done Reason)\tArsenobenzol (Pharmacologic Substance)\tCDISC Questionnaire HAM-D6 Self-Report Version Test Name Terminology (Intellectual Product)\tCopper supplement therapy (Health Care Activity)", + "output": "Copper supplement therapy (Health Care Activity)" + }, + { + "input": "Definition: Intellectual Product described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) During the last week, has it been easy or hard for your child to: Bend over from a standing position and pick up something off the floor?\nConcepts: amelanotic melanoma (Primary malignant neoplasm)\tHAQ02-Get In and Out of Bed (HAQ-DI Without VAS Questionnaire Question)\tNipple Duct Carcinoma (Neoplastic Process)\tprotein amino acid nucleotidylation (cellular protein modification process)\tPODCI2-Bend Over and Pick Up Something (PODCI Adolescent Parent-Reported Version Questionnaire Question)", + "output": "PODCI2-Bend Over and Pick Up Something (PODCI Adolescent Parent-Reported Version Questionnaire Question)" + }, + { + "input": "Definition: Organophosphonates described as an antiviral agent with activity against herpes simplex viruses and other members of the herpes virus family. Phosphonoacetic acid inhibits viral DNA polymerase and inhibits the synthesis of viral DNA.\nConcepts: Phosphonacetic acid (Acetic Acids)\tautologous lymphoma cell lysate-pulsed autologous dendritic cell vaccine (Pharmacologic Substance)\tregulation of duplex DNA melting (Genetic Function)\tBlue, Trypan (Azo derivative)\tdetection of ethylene stimulus (response to ethylene)", + "output": "Phosphonacetic acid (Acetic Acids)" + }, + { + "input": "Definition: Hound described as a densely coated Nordic spitz-type dog, closely associated with the Vikings, that is adept at herding and guarding. The outer coat is thick and hard, with a soft and dense under coat. Coat colors range from wheaten to black with small patches of white on the neck, chest, face, feet, and tip of tail. The average height range is 16-18.5 inches and the average weight range is 26-40 pounds.\nConcepts: Pc-4 (Photosensitizing Agents)\tAntiviral Agent (Drugs and Biologicals)\taerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism (beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, RAF1 (Medical Device)\tNorske Buhund (Canis familiaris)", + "output": "Norske Buhund (Canis familiaris)" + }, + { + "input": "Definition: Manufactured Object described as equipment required for engaging in a sport (such as balls, bats, rackets, skis, skates, ropes, weights) and devices for the protection of athletes during their performance (such as masks, gloves, mouth pieces).\nConcepts: Athletic Equipment (Manufactured Materials)\tGrade 4 Injury to superior vena cava (Injury To Superior Vena Cava, CTCAE)\tmicrotubule site clamp (protein-macromolecule adaptor activity)\tvenous thrombosis (Thrombus)\tAbsorption, Subcutaneous (Absorption, Physiological)", + "output": "Athletic Equipment (Manufactured Materials)" + }, + { + "input": "Definition: Abnormality of urine homeostasis described as an increased concentration of 5-aminolevulinic acid (CHEBI:17549) in the urine.\nConcepts: Increased Time To Concomitant Drug Peak Blood Concentration (Finding)\tano rectal (Anus)\tCSS10-Most Recent Attempt Damage (Intellectual Product)\tpositive regulation of transcription by carbon catabolites (positive regulation of transcription, DNA-templated)\tElevated urinary delta-aminolevulinic acid (LABORATORY ABNORMALITIES)", + "output": "Elevated urinary delta-aminolevulinic acid (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: kininogen binding described as interacting selectively and non-covalently with a kininogen of low molecular mass.\nConcepts: Summary (Mean) T Wave Duration (ECG Measurement)\tTyrosine-Protein Kinase Fes/Fps (Protein Tyrosine Kinase)\tElectronic Collimation (Radionuclide Imaging)\tRetractors, Surgical, Spine (Medical Device)\tLK binding (kininogen binding)", + "output": "LK binding (kininogen binding)" + }, + { + "input": "Definition: something described as the total score for myelodysplastic syndrome progression that considers the percentage of blasts in bone marrow (scored on a scale from zero to 2), chromosome abnormalities (scored from zero to 1), and the patient's blood counts (scored as zero or 0.5).\nConcepts: Intravenous (IV) insertion (Therapeutic or Preventive Procedure)\tInternational Prognostic Scoring System for Myelodysplastic Syndrome Risk Score (Research or Clinical Assessment Tool)\tcytomegalovirus retinitis (Cytomegalovirus Infections)\t/ms (Temporal Concept)\tpositive regulation of eosinophil extravasation (positive regulation of cellular extravasation)", + "output": "International Prognostic Scoring System for Myelodysplastic Syndrome Risk Score (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as a deviation from the normal discoid platelet shape.\nConcepts: Plaster Dosing Unit (Potency Unit)\tCutaneous Melanoma cM0 TNM Finding v7 (Cutaneous Melanoma Clinical Distant Metastasis TNM Finding v7)\tAbnormal platelet shape (Anatomical Abnormality)\tregulation of pH (Organism Function)\tSTAPES ANKYLOSIS WITH BROAD THUMBS AND TOES (Congenital anomaly of toe)", + "output": "Abnormal platelet shape (Anatomical Abnormality)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate, or extent of production of a neurotrophin.\nConcepts: Groups, Support (Organization administrative structures)\tsarcospan (Kras oncogene-associated gene) protein, human (Biologically Active Substance)\tHydrocystoma (Skin, Human)\textrinsic component of dense core granule membrane (extrinsic component of organelle membrane)\tregulation of neurotrophin production (Physiologic Function)", + "output": "regulation of neurotrophin production (Physiologic Function)" + }, + { + "input": "Definition: something described as a primarily uterine reaction with generally indistinct borders and two recognizable regions. These regions are an antimesometrial region containing closely packed mesenchymal cells and a mesometrial region containing mesometrial cells with long cytoplasmic processes and abundant glycogen.\nConcepts: mucosa olfactory (Structure of mucous membrane of nose)\tCD79B protein, human (Biologically Active Substance)\tExperimental Organism Decidual Reaction (Finding)\tA1MICG (Laboratory Procedure)\tGanglion, Gasser's (Structure of middle fossa of cranial cavity)", + "output": "Experimental Organism Decidual Reaction (Finding)" + }, + { + "input": "Definition: something described as a genus of root and butt rot fungi in the family Tricholomataceae that produce rhizomorphs and are facultatively parasitic. Many species are pathogenic to trees causing Armillaria root disease.\nConcepts: intermediate principal nucleus (Body Part, Organ, or Organ Component)\tX;autosome translocation (Disease or Syndrome)\tJejunum and Ileum Neuroendocrine Tumor pTX TNM Finding v8 (Finding)\tArmillaria (Physalacriaceae)\thistone serine kinase activity (histone serine kinase activity)", + "output": "Armillaria (Physalacriaceae)" + }, + { + "input": "Definition: Protein or Enzyme Type Measurement described as a measurement of the cystatin C in a biological specimen.\nConcepts: Cells, Neural Crest (Set of developmental entities)\tFailures, Medical Device (Machine Activity)\tnasogastric tubes (Feeding tube)\tADP,ATP Translocator Protein (Amino Acid, Peptide, or Protein)\tMeasurement of cystatin C (Chemical procedure)", + "output": "Measurement of cystatin C (Chemical procedure)" + }, + { + "input": "Definition: Enterobacteriaceae described as any bacterial organism that can be assigned to the species Yersinia pestis.\nConcepts: Jars, Blade (Jar - device)\tPlague bacillus (Yersinia species)\tPQL08-Hard to Breathe (PedsQL Neuromuscular Module Version 3.0 Parent Report for Young Child Questionnaire Question)\tdrug compounding (Health Care Activity)\tsuppression by virus of host DNA-dependent transcription, initiation (suppression by virus of host transcription)", + "output": "Plague bacillus (Yersinia species)" + }, + { + "input": "Definition: Disasters described as calamity caused by natural forces resulting in substantial damage, loss, and distress.\nConcepts: Increased HDL3c concentration (Finding)\tPhysical Problems Fevers (Findings-Based Question)\targinine catabolic process to ornithine (Molecular Function)\tDisaster, Natural (Natural Phenomenon or Process)\tTopical Emulsion Spray Dosage Form (Topical Spray)", + "output": "Disaster, Natural (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Corneocyte described as protoplasm of a cell exclusive of that of the nucleus; it consists of a continuous aqueous solution (cytosol) and the organelles and inclusions suspended in it (phaneroplasm), and is the site of most of the chemical activities of the cell.\nConcepts: Cytoplasms (Cellular Structures)\tHyperlipoproteinemia Type IIb (Hyperlipoproteinemias)\tRecurrent Adenocarcinoma (Recurrent Carcinoma)\tAdenocarcinoma in situ in a polyp, NOS (Neoplastic Process)\tIKAROS Family Zinc Finger 1 Protein 1 (TRANSCRIPTION FACTOR)", + "output": "Cytoplasms (Cellular Structures)" + }, + { + "input": "Definition: something described as gallbladder cancer with metastases to periaortic, pericaval, superior mesenteric artery, and/or celiac artery lymph nodes.\nConcepts: OL-EDA-ID (anhidrotic ectodermal dysplasia, immunodeficiency, osteopetrosis, lymphedema) syndrome (Milroy Disease)\tOvarian Mucinous Cystadenofibroma (Mucinous cystadenofibroma)\tTraining, Pilates (Therapeutic or Preventive Procedure)\tIntravenous Lethal Injection and Exsanguination Euthanasia (Lethal Injection and Exsanguination Euthanasia)\tGallbladder Cancer pN2 TNM Finding v7 (Finding)", + "output": "Gallbladder Cancer pN2 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Finding described as a risk group associated with a total score of 3 on the International Prognostic Index indicating that an individual has a 5 year survival prognosis of 46%.\nConcepts: 16: 88280579-88290263 (Chromosome 16 Physical Location)\tHereditary hypercarotenemia and vitamin A deficiency (Disease or Syndrome)\tStage IVA Thyroid Gland Follicular Cancer (Stage IV Thyroid Gland Follicular Carcinoma AJCC v8)\tRepeated Measures (Testing)\tIPI High-Intermediate Risk Group (Finding)", + "output": "IPI High-Intermediate Risk Group (Finding)" + }, + { + "input": "Definition: something described as a coded value specifying a classification of the adverse event.\nConcepts: Phosphatidylinositol 3-Kinase, Class I (Enzyme)\tHemophilus (Brucellaceae)\t15: 49403413-49288961 (Chromosome 15 Physical Location)\tJuvenile Secretory Carcinoma of Breast (Invasive carcinoma of breast)\tAdverse Event Category Code (Category Code)", + "output": "Adverse Event Category Code (Category Code)" + }, + { + "input": "Definition: regulation of nucleobase-containing compound transport described as any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: laminin-521 complex location (laminin complex)\tup-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport (regulation of nucleobase-containing compound transport)\tDeviation of the hand or of fingers of the hand (Anatomical Abnormality)\tClusia (Clusieae)\tChloroplasts (Organelles)", + "output": "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport (regulation of nucleobase-containing compound transport)" + }, + { + "input": "Definition: Nervous system neoplasms benign NEC described as a primary, slow growing, noninvasive neoplasm of the brain. In children, astrocytomas of the cerebellum represent relatively common benign brain neoplasms. In adults meningiomas, neurilemomas and pituitary tumors comprise the majority of benign tumors.\nConcepts: Benign brain tumor (Neoplastic Process)\tBiologic Entity Death Date Estimated Indicator (Functional Concept)\tTopoisomerase-IV Inhibitor (Pharmacologic Substance)\tdownregulation of adaptive immune memory response (negative regulation of adaptive immune response)\tCornish Giants (Chickens)", + "output": "Benign brain tumor (Neoplastic Process)" + }, + { + "input": "Definition: Case-Control Studies described as a study in which participants with known outcomes are assessed based on data collected before the study.\nConcepts: leukocyte activation involved in immune response (Cell Function)\tLeiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Distant Metastasis TNM Finding v7 (Finding)\tHydrops Fetalis (Neonatal disease due to placental transfer of antibody)\tresponse to oleic acid (response to fatty acid)\tStudies, Retrospective (Research Activity)", + "output": "Studies, Retrospective (Research Activity)" + }, + { + "input": "Definition: something described as catalysis of the reaction: ATP + N-acetyl-D-galactosamine = ADP + N-acetyl-alpha-D-galactosamine 1-phosphate.\nConcepts: Professional Autonomy (Idea or Concept)\tLYMPHOCYTE ABNORMAL (WHITE CELL AND RES DISORDERS)\tBioterrorism Preparedness (Therapeutic or Preventive Procedure)\tGK2 (phosphotransferase activity, alcohol group as acceptor)\tProstate Carcinoma cT2c TNM Finding v8 (Finding)", + "output": "GK2 (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: SIQR Questionnaire Question described as symptom Impact Questionnaire - Please rate your level of stiffness.\nConcepts: Skin Response Numeric Result in Standard Unit (Numeric Test Result)\tcell adhesive protein binding involved in atrial cardiomyocyte-AV node cell communication (protein binding involved in heterotypic cell-cell adhesion)\tSIQR0114 (Intellectual Product)\tthreonine transport (cation transport)\tactivation of gliotoxin anabolism (positive regulation of sulfur metabolic process)", + "output": "SIQR0114 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether or not an individual had any change in color of their fingernails or toenails over the past seven days.\nConcepts: Esiak (Dietary Supplements)\tIn the last 7 days, did you have any change in the color of your fingernails or toenails (Intellectual Product)\toocytes (Cell)\tdrug serotonin (Biologically Active Substance)\tBobbin Device (Manufactured Object)", + "output": "In the last 7 days, did you have any change in the color of your fingernails or toenails (Intellectual Product)" + }, + { + "input": "Definition: Cytodiagnosis described as video-microscopy procedure for the analysis of the nuclear chromatin organization status in neoplastic lesions and the detection of nuclear subpopulations on hematoxylin-eosin stained sections.\nConcepts: (2R)-hydroxy-carboxylate:acceptor oxidoreductase activity (Molecular Function)\tmexicans (Hispanics)\tDelphinium nuttallianum, Flower essence (Pharmacologic Substance)\tC4 photosynthesis (carbon fixation)\tKaryometry (Light Microscopy)", + "output": "Karyometry (Light Microscopy)" + }, + { + "input": "Definition: Epithelial cell of stomach described as a cell found in the gastric mucosa that produces and secretes digestive enzymes and acid.\nConcepts: Stage I Testicular Seminoma (Tumor stage finding)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, FUS (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tsignaling receptor binding (Molecular Function)\tOABQ0212 (Intellectual Product)\tGastric Glandular Cell (Cell)", + "output": "Gastric Glandular Cell (Cell)" + }, + { + "input": "Definition: positive regulation of amino acid transport described as any process that activates or increases the frequency, rate or extent of aspartate secretion.\nConcepts: ANTIGEN, CF, TYPHUS FEVER GROUP (Indicator, Reagent, or Diagnostic Aid)\tDilated Cardiomyopathy Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy, Dilated)\tupregulation of aspartate secretion (Molecular Function)\tMalabsorption, NOS (Disease or Syndrome)\tStrong Opioids Greater than 600 mg Oral Morphine Equivalent per Day (Finding)", + "output": "upregulation of aspartate secretion (Molecular Function)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of an oil-in-water emulsion intended to be introduced, usually in large volumes, usually into the circulating blood stream.\nConcepts: anthocyanin-containing compound metabolic process (Molecular Function)\tNon-specified HCPCS II dental service restorative reference code no charge (Tracking code use with or without ICD diagnosis)\tEmulsion for infusion (Parenteral dosage form)\tRalstonia mannitolytica (Ralstonia)\tChildhood Brain Stem Mixed Glioma (Neoplastic Process)", + "output": "Emulsion for infusion (Parenteral dosage form)" + }, + { + "input": "Definition: Gene or Genome described as methyltransferase Genes encode Methyltransferases, a subclass of transferase class enzymes that catalyze the transfer of a methyl group from one compound to another.\nConcepts: photosynthesis (Plant Physiological Phenomena)\tMethyltransferase Gene (Transferase Gene)\tYT (South east African country)\tFull Disagreement (Clinical or Research Assessment Answer)\tDrosophila Delta Homolog 3 (Amino Acid, Peptide, or Protein)", + "output": "Methyltransferase Gene (Transferase Gene)" + }, + { + "input": "Definition: something described as the relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.\nConcepts: Tretamine (Aziridines)\tHSATII DNA (Genes, Regulator)\tBase Compositions (Quantitative Concept)\tCisteina (Amino Acids, Sulfur)\tregulation of apical ectodermal ridge formation (Organ or Tissue Function)", + "output": "Base Compositions (Quantitative Concept)" + }, + { + "input": "Definition: something described as any of the terminal sacs in the lungs through which gas exchange takes place with the pulmonary capillary blood.\nConcepts: B-Cell Translocation Gene 1, Anti-Proliferative (BTG2 gene)\tEar, External (Auricle of external ear)\tPulmonary Alveolus (Lung)\tMGC133250 (Gene or Genome)\tMonieziases (Cestode Infections)", + "output": "Pulmonary Alveolus (Lung)" + }, + { + "input": "Definition: something described as version 1.0 of the Parkinson's Disease CDISC therapeutic area user guide.\nConcepts: Uterine Corpus Adenosarcoma Pathologic TNM Finding v8 (Finding)\tRBPH1 (RPN1 gene)\tUNABLE TO OBTAIN SATISFACTORY CORONARY SINUS ACCESS (Finding)\tCDISC Parkinson's Disease Therapeutic Area User Guide Version 1.0 (CDISC Therapeutic Area User Guide Name and Version)\tSPRAYS, SYNTHETIC, SMEAR (Indicator, Reagent, or Diagnostic Aid)", + "output": "CDISC Parkinson's Disease Therapeutic Area User Guide Version 1.0 (CDISC Therapeutic Area User Guide Name and Version)" + }, + { + "input": "Definition: Abnormal urine carbohydrate level described as an increase in the level of galactitol in the urine.\nConcepts: UDP-glucose:glycoprotein glucose-1-phosphotransferase activity (phosphotransferase activity, for other substituted phosphate groups)\tAUCIFPW (Area Under Curve)\tIVD Test Reagent/Kits, Cytology/Histology, Decalcifying, Light Microscopy (IVD Test Reagent/Kits, Cytology/Histology, Decalcifying)\tOxaluria, Primary (Hereditary nephropathy)\tIncreased level of galactitol in urine (Finding)", + "output": "Increased level of galactitol in urine (Finding)" + }, + { + "input": "Definition: Lesion of gallbladder described as tumors or cancer of the gallbladder.\nConcepts: Study Site Protocol Version Relationship Effective Date Range (Temporal Concept)\tGallbladder neoplasm (Hepatobiliary neoplasms malignancy unspecified)\tSheets, Patient Bed, Disposable (Bed sheets)\t7-Hydroxy-staurosporine (Organic Chemical)\tDecreased circulating copper concentration (Mineral deficiency)", + "output": "Gallbladder neoplasm (Hepatobiliary neoplasms malignancy unspecified)" + }, + { + "input": "Definition: Phosphotransferases described as phosphatidylinositol 4-kinase beta (816aa, ~91 kDa) is encoded by the human PI4KB gene. This protein plays a role in the first step of inositol-1,4,5,-trisphosphate production.\nConcepts: Phosphatidylinositol 4 Kinase (Transferase)\tEDO-S 101 (Organic Chemical)\tIVD Test Reagent/Kits, Home Assay, Urine (Medical Device)\tCells, K562 (Cell Line, Tumor)\tProstheses, Upper Limb, Wrist Component, Myoelectric (Medical Device)", + "output": "Phosphatidylinositol 4 Kinase (Transferase)" + }, + { + "input": "Definition: Autosomal dominant hereditary disorder described as an autosomally inherited (generally dominant) coagulation disorder characterized by quantitative partial deficiency of circulating von Willebrand factor (VWF) which account for 60 to 80% of cases of von Willebrand disease. It is characterized by mild to moderate quantitative deficiencies of VWF and factor VIII, which are coordinately reduced from normal plasma levels.\nConcepts: PQL09-Back Feels Stiff (PedsQL Neuromuscular Module Version 3.0 Parent of Toddler Questionnaire Question)\tvon Willebrand Disease, Type I (Autosomal dominant hereditary disorder)\tSyp1 dimer (Cell Component)\tAUH protein, human (Amino Acid, Peptide, or Protein)\tGrade 1 Colitis (Finding)", + "output": "von Willebrand Disease, Type I (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: something described as focally amplified long non-coding RNA in epithelial cancer (566 bp) is encoded by the human FALEC gene. This non-coding RNA may be involved in oncogenesis.\nConcepts: Walking within the house (Clinical or Research Assessment Question)\tExtent of Sexual Enjoyment (Clinical or Research Assessment Question)\tGCC codon-amino acid adaptor activity (Genetic Function)\tFAL1 (Pharmacologic Substance)\tRationalisation - mental defence mechanism (Mental Process)", + "output": "FAL1 (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as any process in which a transposable element is incorporated into another DNA molecule such as a chromosome.\nConcepts: transposon integration (Genetic Function)\tReadiness Score 6 (Clinical or Research Assessment Answer)\tImidazoles (Pharmacologic Substance)\tPartial/complete duplication of the distal phalanges of the hand (Foot)\tFNCLCC Sarcoma Grade 2 (Neoplastic Process)", + "output": "transposon integration (Genetic Function)" + }, + { + "input": "Definition: Device Labeled for Single Use described as inflatable, hollow rubber devices (i.e., balloons) designed to be used with balloon endoscopes intended for examination of the gastrointestinal tract, particularly the small bowel (i.e., enteroscopes). These balloons are typically single-use devices constructed of latex or silicone. Some enteroscope balloons are attached directly to the distal end of the endoscope and inflated via a dedicated balloon inflation channel in the endoscope. Alternatively, some enteroscope balloons are attached to the distal end of an air supply tube, which is passed through the working channel of the endoscope.\nConcepts: Phosphatidyl N Methylethanolamine N Methyltransferase (Amino Acid, Peptide, or Protein)\tpropionibacterium avidum (Propionibacterium)\tEnteroscope Balloons (Medical Device)\tMD (Neuromuscular Diseases)\tDevice Contaminated during manufacture or shipping (Manufacturing, Packaging or Shipping Problem)", + "output": "Enteroscope Balloons (Medical Device)" + }, + { + "input": "Definition: something described as disorders which occur in animals but not in man\nConcepts: Tripartite Motif Containing 5 wt Allele (Gene or Genome)\tLaryngeal voice function, NOS (oral function)\tGrade 1 Lipase Increased, CTCAE (Finding)\tPseudoepiphyses of the metacarpals (Finding)\tNon-human disease (Disease)", + "output": "Non-human disease (Disease)" + }, + { + "input": "Definition: Late Relapse described as clinical and/or laboratory evidence of reemergence of acute lymphoblastic leukemia greater than or equal to 18 months (extramedullary) or 36 months (marrow) from diagnosis.\nConcepts: Peripheral lymph (Body Substance)\tActinomadura (Bacterium)\tFertilization (Functions and Abnormal Functions Associated with the Reproductive State)\tLate Relapse of ALL (Late Relapse)\taralia nudicaulis/wild sarsa (Western herbs and natural substances letter A)", + "output": "Late Relapse of ALL (Late Relapse)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Version 3 Young Adult - In the past one month, how much of a problem has this been for you: I think money is a problem in our family.\nConcepts: LEU9 Negative (Expression Negative)\tUDP-glycosyltransferase activity (glycosyltransferase activity)\tPedsQL Neuromuscular Module Version 3.0 Young Adult Report - Money Problem in Our Family (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)\tJCH (Gene or Genome)\tPenile Cancer Clinical Distant Metastasis TNM Finding v7 (Penile Cancer Clinical TNM Finding v7)", + "output": "PedsQL Neuromuscular Module Version 3.0 Young Adult Report - Money Problem in Our Family (PedsQL Neuromuscular Module Version 3.0 Young Adult Report Questionnaire Question)" + }, + { + "input": "Definition: something described as echinococcus spp. serological reagents are devices that consist of Echinococcus spp. antigens and antisera used in serological tests to identify antibodies to Echinococcus spp. in serum. The identification aids in the diagnosis of echinococcosis, caused by parasitic tapeworms belonging to the genus Echinococcus and provides epidemiological information on this disease. Echinococcosis is characterized by the development of cysts in the liver, lung, kidneys, and other organs formed by the larva of the infecting organisms.\nConcepts: Size, Litter (Pregnancy, Animal)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Leptospira Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)\tANTIGEN, AGGLUTINATING, ECHINOCOCCUS SPP. (Indicator, Reagent, or Diagnostic Aid)\tProvince (Geographic Area)\tinterpersonal psychotherapy (Psychological therapies)", + "output": "ANTIGEN, AGGLUTINATING, ECHINOCOCCUS SPP. (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Pharmacologic Substance described as drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.\nConcepts: cellular response to heparin (response to heparin)\tBLOOD PLATELET AGGREGATION INHIB (Hematologic Agents)\tInterstitial Myositis (Myositis)\tMeconium Ileus (Perinatal intestinal obstruction)\t12q13.1-q13.3 (Chromosome band)", + "output": "BLOOD PLATELET AGGREGATION INHIB (Hematologic Agents)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the collagen, type IV, alpha 4 (COL4A4) gene, located at chromosome 2q35-37, which encodes for alpha 4 (IV) chain of type IV collagen. Mutations at this locus have been identified in patients with diseases that include Alport's syndrome and basement membrane nephropathy.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL4A4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tlimit setng asistnce (Psychosocial intervention strategy)\tsterol transporter activity (Molecular Function)\tBRCA-Mutated Malignant Neoplasm (Hereditary Malignant Neoplasm)\tBony callus (Morphologically abnormal structure)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL4A4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk & Resilience Inventory-2 - During deployment: I could count on my family members or friends at home for good advice.\nConcepts: Banding Artifact (Off-resonance Effect)\tCOWS101A (Intellectual Product)\tLABWARE, ASSISTED REPRODUCTION (Medical Device)\tDRRI1-I: Could Count on Family Advice (DRRI-2 Questionnaire Question)\tMacular cotton wool spot (Yellow/white lesions of the macula)", + "output": "DRRI1-I: Could Count on Family Advice (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM.\nConcepts: Isotopes, Strontium (strontium)\tmotions (Physical Phenomena)\tBase of heart (Region of surface of heart)\tbis(4-chlorophenyl)acetate decarboxylase activity (carboxy-lyase activity)\tGOITER, FAMILIAL (Thyroid disorders NEC)", + "output": "bis(4-chlorophenyl)acetate decarboxylase activity (carboxy-lyase activity)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of protein localization to phagocytic vesicle.\nConcepts: seed oil body organization (Cell Function)\tShapes, Cell (Organism Attribute)\tAtrioventricular Reentrant Tachycardia (Finding)\tFAST GREEN (Organic Chemical)\tdownregulation of protein localization to phagocytic vesicle (negative regulation of cellular protein localization)", + "output": "downregulation of protein localization to phagocytic vesicle (negative regulation of cellular protein localization)" + }, + { + "input": "Definition: something described as international Physical Activity Questionnaire (November 2002) - Long Last 7 Days Telephone Format - During the last 7 days, on how many days did you bicycle to go from place to place?\nConcepts: IPA0210 (Intellectual Product)\tSTXBP1 encephalopathy with epilepsy (X-linked infantile spasms)\tMedial mammillary nucleus, medial part (Structure of medial mammillary nucleus)\tdalotuzumab (Immunologic Factor)\tNCI CTEP Simple Disease Classification Vascular Tumor, Miscellaneous Sub-Category Terminology (NCI CTEP SDC Miscellaneous Neoplasm Category Terminology)", + "output": "IPA0210 (Intellectual Product)" + }, + { + "input": "Definition: something described as HIV mutation in the reverse transcriptase (RT) coding region\nConcepts: eighth visual area (Body Location or Region)\tmetallopanstimulin-1 protein, human (Ribosomal Proteins)\tRectal Snares (Medical Device)\tAuthoringDevice (Devices)\tK20R (Cell or Molecular Dysfunction)", + "output": "K20R (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Organic Chemical described as dye and chemical solution stains for medical purposes are mixtures of synthetic or natural dyes or nondye chemicals in solutions used in staining cells and tissues for diagnostic histopathology, cytopathology, or hematology.\nConcepts: Peptidylprolyl Isomerase (Enzyme)\tPICRO METHYL BLUE (Organic Chemical)\tendosomal lumen acidification (intracellular pH reduction)\tOxythiamine (Organic Chemical)\tSulfolobus islandicus Rod Shaped Viruses (Virus)", + "output": "PICRO METHYL BLUE (Organic Chemical)" + }, + { + "input": "Definition: developmental growth described as the increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state.\nConcepts: MMSE - What Is the State (Intellectual Product)\tMATRIX METALLOPROTEINASE 16 (Metallopeptidase Gene)\tspongiotrophoblast layer developmental growth (Organism Function)\tTranslocations (Chromosomal morphology)\tMalignant Pericytic Neoplasm (Neoplastic Process)", + "output": "spongiotrophoblast layer developmental growth (Organism Function)" + }, + { + "input": "Definition: Intellectual Product described as the Expanded Prostate Cancer Index Composite Short Form - How big a problem, if any, has each of the following been for you during the last 4 weeks? Pain or burning on urination.\nConcepts: EPIC104B (Intellectual Product)\tEnteritis caused by radiation (Intestinal Diseases)\tGLRX Gene (Oxidoreductase Gene)\th.pmol/l/kg (Measurement Unit Description)\tAmendmentChangeSummaryVersion (Intellectual Product)", + "output": "EPIC104B (Intellectual Product)" + }, + { + "input": "Definition: Measurement of substance described as a quantitative measurement of the amount of an electrolyte present in a sample.\nConcepts: purine nucleoside diphosphate metabolic process (Molecular Function)\tDistal Ureter (Body Part, Organ, or Organ Component)\tAURCPEP (Quantitative Concept)\tElectrolytes measurement, NOS (Laboratory Procedure)\tLBREASEX (Idea or Concept)", + "output": "Electrolytes measurement, NOS (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a term that refers to the staging of appendiceal carcinoma according to the American Joint Committee on Cancer, 7th edition. Carcinoid tumors are staged separately.\nConcepts: Mean P Wave Duration (ECG Measurement)\tActivities involving wrestling (Daily or Recreational Activity)\tchromosomes x (Cell Component)\tAppendiceal Carcinoma by AJCC v7 Stage (Carcinoma of the Appendix)\tThematic Apperception Test (Projective Techniques)", + "output": "Appendiceal Carcinoma by AJCC v7 Stage (Carcinoma of the Appendix)" + }, + { + "input": "Definition: Disorder of nasal cavity described as catarrhal disorder of the upper respiratory tract, which may be viral or a mixed infection; marked by acute coryza, slight rise in temperature, chilly sensations, and general indisposition.\nConcepts: mannitol degradation (Molecular Function)\tTwin Type (Organism Attribute)\tHLA-DR13 antigen (HLA-DRw antigen)\tcatarrh; nasal, acute (Virus Diseases)\tArthrogryposis, Distal, Type IIb (Arthrogryposis)", + "output": "catarrh; nasal, acute (Virus Diseases)" + }, + { + "input": "Definition: Laboratory Procedure described as a relative measurement (ratio) of the total apolipoprotein A to apolipoprotein B in a biological specimen.\nConcepts: External Occlusion Clamps (Clamp)\tDistention (Dilatation, Distention and Diverticulum)\tMeasurement of ratio of apolipoprotein A to apolipoprotein B (Protein or Enzyme Type Measurement)\tPlanned Trial Duration (Planned Duration)\tIn eye (Ophthalmic Route of Drug Administration)", + "output": "Measurement of ratio of apolipoprotein A to apolipoprotein B (Protein or Enzyme Type Measurement)" + }, + { + "input": "Definition: Benign neuroendocrine tumor described as a benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to or in the bifurcation of the common carotid artery. Most patients present with a slow growing, painless mass in the neck.\nConcepts: C165892 (Laboratory Procedure)\tDIDEOXYCYTIDINE 002 003 (Transferase inhibitor)\tHypothalamohypophyseal Portal System (Body System)\tglia cell migration (Cell Function)\tParagangliomas, Carotid Body (Neck Neoplasms)", + "output": "Paragangliomas, Carotid Body (Neck Neoplasms)" + }, + { + "input": "Definition: regulation of multicellular organismal process described as any process that modulates the frequency, rate or extent of epithelial cell migration.\nConcepts: regulation of epithelial cell migration (Cell Function)\tcalf of leg (Structure of subregion of lower limb)\tCannula Guide Device (Guide device)\tSTREPTOMYCES PARAGUAYENSIS (Bacterium)\tIn Vitro Route of Administration (Functional Concept)", + "output": "regulation of epithelial cell migration (Cell Function)" + }, + { + "input": "Definition: Organic Chemical described as cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.\nConcepts: Blue-green Algae Supplement (Food)\tbeta-Cyclodextrins (Organic Chemical)\tdwarf mistletoes (Plant)\tCongenital trigeminal anaesthesia (Fifth cranial nerve finding)\tneoplasm of bone marrow (Hematologic Neoplasms)", + "output": "beta-Cyclodextrins (Organic Chemical)" + }, + { + "input": "Definition: Format described as a format that does not specify any text properties and does not require pre-established arrangement or organization of data.\nConcepts: hemangiosarcomas (Neoplasms, Connective Tissue)\tFree Text Format (Format)\tMLA1 (CD63 gene)\tsynaptic vesicle lumen (cytoplasmic vesicle lumen)\tAbnormality of middle finger phalanges (Anatomical Abnormality)", + "output": "Free Text Format (Format)" + }, + { + "input": "Definition: Medical Device described as instruments designed to cut and remove circular sections of an object or anatomic structure when driven by a rotary force (i.e., torque). Trephines may consist of a manual, handheld instrument with a blade and an integral handle or, more frequently, of detachable blades and a rotary manual or power (e.g., electrical, pneumatic) drill or handpiece. Trephine blades are usually hollow cylinders with a circular-saw-like beveled working edge that may include a coaxial piece at the center for guiding purposes. Dedicated trephines are available for cutting and removing sections of tissue for examination (i.e., biopsy) and for use in surgical procedures of the skull, eyes, and other tissue and organs.\nConcepts: anti-MAGE-A3 HLA-A*01-restricted TCR-gene engineered lymphocytes (Antineoplastic Immune Cell)\tAmniocentesis Procedure Kit/Trays (Medical Device)\tendolysosomal membrane (Membrane of lysosome)\tTREPHINE (ORTHOPEDIC DEVICES AND HARDWARE)\tMitochondrial PTENalpha (Enzyme)", + "output": "TREPHINE (ORTHOPEDIC DEVICES AND HARDWARE)" + }, + { + "input": "Definition: Identifier type described as the numerical identifier of the visit.\nConcepts: crotonyl-CoA hydratase activity (Molecular Function)\tSprouty (Drosophila) Homolog 1 (Amino Acid, Peptide, or Protein)\tVISITNUM (Identifier type)\tAdrenal Cortical Carcinoma pT1 TNM Finding v8 (Adrenal Cortical Carcinoma Pathologic Primary Tumor TNM Finding v8)\tPhysical Comfort Promotion (Health Care Activity)", + "output": "VISITNUM (Identifier type)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version Phase 1 Study 1/14/09 (C-SSRS Baseline/Screening Version Phase 1 Study 1/14/09) Have you actually had any thoughts of killing yourself? (Lifetime).\nConcepts: CSS0302A (Intellectual Product)\tACI (Mammal)\tMatrix Metalloproteinase Inhibitor MMI270 (Pharmacologic Substance)\tMitochondria RNA (RNA)\tGenetic Reference Sequence Identifier (Intellectual Product)", + "output": "CSS0302A (Intellectual Product)" + }, + { + "input": "Definition: something described as this gene plays a role in the hydrolysis of oxidized nucleotides.\nConcepts: histone deacetylase binding (Molecular Function)\tnudix hydrolase 1 (Gene or Genome)\tWD4D5 2 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tIf you had pain did it increase with activity (Intellectual Product)\tAspartate Beta-Hydroxylase Positive (Positive Laboratory Test Result)", + "output": "nudix hydrolase 1 (Gene or Genome)" + }, + { + "input": "Definition: Peptides described as a group of peptides characterized by length of 1-2 dozen residues with a high proportion of them being non-proteinogenic, notably alpha-aminoisobutyric acid (Aib) and isovaline, and have a C-terminal amino alcohol and N terminal alkyl group. They are found in FUNGI and some are ANTI-INFECTIVE AGENTS. They form channels or pores in target organisms. The term is a contraction of peptide-Aib-alcohol.\nConcepts: NOTCH1 p.Gln2503Ter (NOTCH1 Protein Variant)\tbacterial-type flagellum secretion apparatus (cellular anatomical entity)\tpituitary hemorrhage (Nervous system haemorrhagic disorders)\tPeptaibol (Peptides)\tcounseling about abortion (Family Planning)", + "output": "Peptaibol (Peptides)" + }, + { + "input": "Definition: Liver and Intrahepatic Bile Duct Epithelial Neoplasm described as a premalignant neoplastic lesion of the liver. It is characterized by the presence of hepatocytes with decreased cell volume, increased nuclear/cytoplasmic ratio, basophilia, mild nuclear pleomorphism, and hyperchromasia.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Control, Anemia Test (Medical Device)\tDosing Frequency (Functional Concept)\tTrochlear Nerve Diseases (Cranial nerve diseases)\tSmall Cell Dysplasia (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)\tX ray emission spectrometry (Spectrometry)", + "output": "Small Cell Dysplasia (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)" + }, + { + "input": "Definition: Research Activity described as a technique for measuring microscopic optical density on exposed film or photographic images through the detection of faint spectral lines.\nConcepts: 20q12-q13.11 (Chromosome band)\tProximity (Property or Attribute)\tMicrodensitometry (Densitometry)\tNomenclature (Intellectual Product)\tThromboxane Activity Induction (Cell Function)", + "output": "Microdensitometry (Densitometry)" + }, + { + "input": "Definition: something described as a single citation covering papers or abstracts presented at a meeting. The publication type may be used for a single citation with or without the additional indexing or cataloging of individual papers. The individual papers, however, are not labeled OVERALL.\nConcepts: triglyceride biosynthesis (acylglycerol biosynthetic process)\tbutanedioic acid compound with 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenol (1:1), monohydrate (Organic Chemical)\tOverall (Congresses)\tactivation of DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis (Cell Function)\tprimary somatosensory cortex, trunk region (primary somatosensory cortex)", + "output": "Overall (Congresses)" + }, + { + "input": "Definition: Malignant squamous tumor described as a malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.\nConcepts: Lymphatic chain (Subdivision of lymphatic tree)\tviroplasm viral factory (Cell Component)\tMatricaria recutita / Roman camomile (Pharmacologic Substance)\tpapillary carcinoma (Neoplastic Process)\tDental-Enamel Junction (Body Part, Organ, or Organ Component)", + "output": "papillary carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as athamanta.\nConcepts: NXPE1 Gene (Genes, Regulator)\tEarly onset petit mal seizures (Absence Epilepsy)\tSeverity of Symptom Score 4 (Finding)\tathamanta oreoselium/peuceda (Homeopathic remedies letter A)\tGPCR150 (GPR160 gene)", + "output": "athamanta oreoselium/peuceda (Homeopathic remedies letter A)" + }, + { + "input": "Definition: Cell Adhesion Molecule Gene described as this gene is involved in cell-matrix adhesion-dependent signaling.\nConcepts: The Oswestry Disability Index Version 2.1a Questionnaire Test Name (CDISC Questionnaire Terminology)\tProduct containing methoxamine (Adrenergic Agents)\tob services artificial rupture of membranes (Therapeutic or Preventive Procedure)\tALPHA RELATED TO THE DEVELOPMENT OF LUNG CANCER (Gene or Genome)\tGenus Vibrio (Vibrio)", + "output": "ALPHA RELATED TO THE DEVELOPMENT OF LUNG CANCER (Gene or Genome)" + }, + { + "input": "Definition: Helicobacter pylori antibody Test described as the determination of the amount of the Helicobacter pylori IgG antibody in a sample.\nConcepts: Helicobacter pylori IgG Antibody (Helicobacter pylori antibody Test)\tmodulation by symbiont of defense-related host calcium-dependent protein kinase pathway (modulation by symbiont of host defense response)\tInfraclavicul lymph node group (Lymph node group)\tIVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification, Two Cell Screening (IVD Test Reagent/Kits, Immunohematology, Antibody Detection/Identification)\tPropoxyphene-containing product (Propionates)", + "output": "Helicobacter pylori IgG Antibody (Helicobacter pylori antibody Test)" + }, + { + "input": "Definition: Duplicate concept described as a malignant cartilaginous matrix-producing mesenchymal neoplasm arising from the bone and soft tissue. It usually affects middle-aged to elderly adults. The pelvic bones, ribs, shoulder girdle, and long bones are the most common sites of involvement. Most chondrosarcomas arise de novo, but some may develop in a preexisting benign cartilaginous lesion.\nConcepts: cyanogenic glycoside formation (glycoside biosynthetic process)\tcmpndng homeo rmds ea.5min (Therapeutic or Preventive Procedure)\tBioelectric Field Imaging (Diagnostic Procedure)\tCHONDROSARCOMA, MALIGNANT (Malignant Neoplasms)\tAbnormal proportion of CD4-positive helper T cells (Abnormal T cell subset distribution)", + "output": "CHONDROSARCOMA, MALIGNANT (Malignant Neoplasms)" + }, + { + "input": "Definition: something described as the absence or restriction of the usual external sensory stimuli to which the individual responds.\nConcepts: Colorectal (Colon or Rectal) Gastrointestinal Stromal Tumor (Colorectal Neoplasms)\tNEVI MELANOMAS (Nevus AND/OR melanoma)\tNorthwest Territories of Canada (Northern Territories of Canada)\tdownregulation of activated T cell autonomous cell death (negative regulation of T cell apoptotic process)\tSensory deprivation isolation (Perception)", + "output": "Sensory deprivation isolation (Perception)" + }, + { + "input": "Definition: Cell Component described as a structure or space in a prokaryotic cell.\nConcepts: ketorolac (Cyclooxygenase 2 Inhibitors)\tHysterical disorder, NOS (other psychiatric disorders)\tTurbines, Whirlpool Bath (Medical Device)\tPercent Change Baseline in Sum of PPD (Mass Measurement)\tPROKARYOTIC CELL COMPONENTS (Cells)", + "output": "PROKARYOTIC CELL COMPONENTS (Cells)" + }, + { + "input": "Definition: Qualitative Concept described as the distribution and abundance of taxa in a biological or ecological community.\nConcepts: Hyperhidrosis symptom (skin moisture)\tHerpetiform (Spatial Concept)\tDifficult Some of the Time (Clinical or Research Assessment Answer)\tecliptae/han lian cao (Plant)\tCommunity Compositions, Ecological (Qualitative Concept)", + "output": "Community Compositions, Ecological (Qualitative Concept)" + }, + { + "input": "Definition: positive regulation of mitotic cell cycle described as any process that activates or increases the frequency, rate or extent of mitotic spindle organization.\nConcepts: positive regulation of mitotic spindle organization (positive regulation of mitotic cell cycle)\tnitrobenzene 1,2-dioxygenase activity (Molecular Function)\tinpatient care (Institutionalization)\tRobbery, Grave (Crime Act)\tCotton Gauze Dressings (Dressings, Nonimpregnated, Natural Fiber)", + "output": "positive regulation of mitotic spindle organization (positive regulation of mitotic cell cycle)" + }, + { + "input": "Definition: Physiologic Function described as a reproductive process occurring in the mother that allows an embryo or fetus to develop within it.\nConcepts: DIFFER FACTOR B CELL (Amino Acid, Peptide, or Protein)\tStage IV Fallopian Tube Cancer (Neoplastic Process)\tmaternal process involved in female pregnancy (Physiologic Function)\tNeonatal multifocal clonic seizure (Neonatal electro-clinical clonic seizure)\tQS-PROSQOLI TESTCD (Intellectual Product)", + "output": "maternal process involved in female pregnancy (Physiologic Function)" + }, + { + "input": "Definition: Molecular Function described as a constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan.\nConcepts: extracellular matrix structural constituent conferring compression resistance (Molecular Function)\tHyperfibrinogenemia (Fibrinogen abnormality)\tClumber Spaniel (Mammal)\tIVD Test Reagent/Kits, Immunoassay, Gastrointestinal Hormone, Gastric Inhibitory Polypeptide (Medical Device)\tFAC028-I Have Nausea (Intellectual Product)", + "output": "extracellular matrix structural constituent conferring compression resistance (Molecular Function)" + }, + { + "input": "Definition: Confidentiality Code described as a coded value specifying the degree of privacy applicable for the observation result.\nConcepts: NPI1D04 (Intellectual Product)\tPerformedObservationResult.confidentialityCode (Intellectual Product)\tPSYCHOPHARMACOL (Behavioral Sciences)\tpositive regulation of ethylene biosynthetic process (positive regulation of olefin biosynthetic process)\tDual Cholate Test (Liver Function Tests)", + "output": "PerformedObservationResult.confidentialityCode (Intellectual Product)" + }, + { + "input": "Definition: Mechanical Phenomena described as evaluation of mechanical properties of material or a device.\nConcepts: Feel Overwhelmed by Condition (Intellectual Product)\tmethotrexate binding (amide binding)\tTests, Mechanical (Materials Testing)\tAUDIT-C - How Often Have Alcohol Drink (Intellectual Product)\tdyslipidemia (LABORATORY ABNORMALITIES)", + "output": "Tests, Mechanical (Materials Testing)" + }, + { + "input": "Definition: Pharmacologic Substance described as brand name of a high blood pressure medication\nConcepts: Fossil Fuel (Substance)\tDiovan (Pharmacologic Substance)\ttrivalent inorganic cation transmembrane transporter activity (Molecular Function)\tsedimentation (Physical Phenomenon or Property)\tAlpha Glutathione-S-Transferase Measurement (Laboratory Procedure)", + "output": "Diovan (Pharmacologic Substance)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the cadherin-related 23 (CDH23) gene, located at chromosome 10q22.1, which encodes the protein cadherin-23. Genetic variants at this locus have been associated with autosomal recessive deafness 12 and Usher syndrome, type 1D.\nConcepts: OVARY, TERATOMA (cellular diagnosis, ovarian germ cell tumor)\tDiscordant atrioventricular connexion (Abnormal atrioventricular connection - biventricular)\tCDR-H3 (Amino Acid Sequence)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CDH23 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tregulation of exonuclease activity (Molecular Function)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CDH23 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Medical Device described as a partial denture intended for short-term use in a temporary or emergency situation.\nConcepts: perception of bacteria (detection of other organism)\tDenture, Partial, Temporary (Denture, Partial)\tClostridium difficile A/B Toxin (Clinical Attribute)\twheelchair pads (Durable Medical Equipment)\tDiphylline (Antispasmodics)", + "output": "Denture, Partial, Temporary (Denture, Partial)" + }, + { + "input": "Definition: Diagnostic Procedure described as an imaging procedure that combines C-11 choline PET with an MRI scan to overlay activity data onto detailed anatomic images.\nConcepts: Transdermal spray, solution (Solution Dosage Form)\tcognitive disorder (Cognitive and attention disorders and disturbances NEC)\tPI3K Gene Mutation (Cell or Molecular Dysfunction)\tElder Nutritional Physiological Phenomena (Nutritional Physiological Phenomena)\tC-11 Choline PET/MRI (Diagnostic Procedure)", + "output": "C-11 Choline PET/MRI (Diagnostic Procedure)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of two subdivisions of the dentate nucleus of the cerebellar nuclei. Identified by its population of small neurons, it is found in the human ( Voogd-1990 ), the macaque ( Paxinos-2009a ), the rat ( Swanson-2004 ) and the mouse ( Franklin-2008 ). The other subdivision is the magnocellular part of the dentate nucleus.\\r\\n\nConcepts: CETP (Carrier Proteins)\tlateral cerebellar nucleus, parvicellular part (Body Part, Organ, or Organ Component)\tSilver Birch Pollen IgA (Laboratory Procedure)\tOcular infections (Classification)\tPenis Erectile Tissue (Tissue)", + "output": "lateral cerebellar nucleus, parvicellular part (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that 5 to 19 minutes were spent on an activity.\nConcepts: thiamine:hydrogen symporter activity (solute:proton symporter activity)\tterminal cisterna lumen (Cell Component)\tFive to Nineteen Active Minutes (Clinical or Research Assessment Answer)\tglycyl-tRNA synthetase 1 (Ligase Gene)\tTyrosine hydroxylase (Enzymes)", + "output": "Five to Nineteen Active Minutes (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Chromosome band described as a chromosome band present on 5q\nConcepts: Millimole/minute (Moles per unit time)\tAbnormal meniscus morphology (Abnormality of the knee)\tNF-AT3 (TRANSCRIPTION FACTOR)\tFLT1 Gene Mutation (Gene Mutant)\t5q11.2 (Cell Component)", + "output": "5q11.2 (Cell Component)" + }, + { + "input": "Definition: Paranasal Sinus Neoplasms described as a benign or malignant neoplasm that affects the maxillary sinus. Representative examples of benign neoplasms include Schneiderian papilloma and salivary gland-type adenoma. Representative examples of malignant neoplasms include carcinoma and lymphoma.\nConcepts: Hernia Trusses, Infant (Trusses)\tTumour of maxillary antrum (Neoplastic Process)\tRCPCIFOS (Quantitative Concept)\tLocally extensive (Disease Clinical Qualifier)\tELECTROMYOGRAPH, DIAGNOSTIC (Myograph)", + "output": "Tumour of maxillary antrum (Neoplastic Process)" + }, + { + "input": "Definition: Malignant neoplasm of urinary bladder described as stage II includes: (T2a, N0, M0); (T2b, N0, M0). T2a: Tumor invades superficial muscle (inner half). T2b: Tumor invades deep muscle (outer half). N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: dJ576K7.1 (FK506 Binding Protein 12-Rapamycin Associated Protein 1) Gene (MTOR gene)\tJewett-Marshall Stage B Bladder Carcinoma (stage, bladder cancer)\tAPC (cullin-RING ubiquitin ligase complex)\tregulation of growth plate cartilage chondrocyte differentiation (regulation of chondrocyte differentiation involved in endochondral bone morphogenesis)\tStage IVB Colorectal Cancer AJCC v7 (Neoplastic Process)", + "output": "Jewett-Marshall Stage B Bladder Carcinoma (stage, bladder cancer)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways resulting in the formation of alpha-copaene.\nConcepts: liposaccharide metabolism (carbohydrate derivative metabolic process)\tPerformed Lesion Description (Performed Clinical Study Activity)\tColloid, body substance (Body Substance)\tLate onset immunoglobulin deficiency (Immunologic Deficiency Syndromes)\talpha-copaene anabolism (Molecular Function)", + "output": "alpha-copaene anabolism (Molecular Function)" + }, + { + "input": "Definition: drug catabolic process described as the chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid.\nConcepts: Minor Salivary Gland Carcinoma (Salivary gland carcinoma)\tCADUSAFOS (Acetylcholinesterase Inhibitors)\tTFIIF-class transcription factor complex binding (protein-containing complex binding)\tpropionate catabolism (Molecular Function)\tdown regulation of melanization defense response (negative regulation of innate immune response)", + "output": "propionate catabolism (Molecular Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.\nConcepts: 5q11-q12 (Cell Component)\tmitomycin C formation (organic cyclic compound biosynthetic process)\tspongiotrophoblast cell proliferation (Cell Function)\tWnt Protein (Amino Acid, Peptide, or Protein)\tTransmittal (Techniques M-Z)", + "output": "Wnt Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's agreement concerning not being able to plan for the future because cancer is unpredictable.\nConcepts: down-regulation of high voltage-dependent calcium channel activity (regulation of high voltage-gated calcium channel activity)\tCannot Plan for the Future Because Cancer is Unpredictable (Clinical or Research Assessment Question)\tPersonnel, Laboratory (Workers)\tCynomolgus Maritius Monkey (Mammal)\tAQ20 - Worry About Long Term Effects of Drugs for Chest Trouble (AQ20 Questionnaire Question)", + "output": "Cannot Plan for the Future Because Cancer is Unpredictable (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as a neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.\nConcepts: Galanin (Amino Acid, Peptide, or Protein)\tDiaphragmatic hernia, NOS (Diaphragmatic Hernia)\tAVL01126 (ADNI-AVLT Questionnaire Question)\taccessory outer segment (Neurites)\tOTITIS (Disease or Syndrome)", + "output": "Galanin (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Health Care Related Organization described as an institute within the National Institutes of Health that supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases, the training of basic and clinical scientists to carry out this research, and the dissemination of information on research progress in these diseases.\nConcepts: Recurrent Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (Recurrent Hematologic Malignancy)\tResidue on Ignition (Qualitative Concept)\tNational Institute of Arthritis and Musculoskeletal and Skin Diseases (United States National Institutes of Health)\tAlcohol Use Disorder Identification Test Alcohol Consumption Questions Questionnaire (Clinical or Research Assessment Questionnaire)\tCortical Congenital Hyperostoses (Hyperostosis)", + "output": "National Institute of Arthritis and Musculoskeletal and Skin Diseases (United States National Institutes of Health)" + }, + { + "input": "Definition: Unknown Primary Tumor cN3 TNM Finding v8 described as unknown primary tumor with metastasis in any cervical node(s) with clinically overt ENE(+) (ENEc). ENEc is defined as invasion of skin, infiltration of musculature, dense tethering or fixation to adjacent structures, or cranial nerve, brachial plexus, sympathetic trunk, or phrenic nerve invasion with dysfunction.\nConcepts: Microcephalus microcornea syndrome of Seemanova type (Microcephaly)\tUnknown Primary Tumor cN3b TNM Finding v8 (Unknown Primary Tumor cN3 TNM Finding v8)\tMicrospheres, Embolization (Medical Device)\tSuperior part of fibrous pericardium (Subdivision of fibrous pericardium)\tblood testis barrier (Biological Transport)", + "output": "Unknown Primary Tumor cN3b TNM Finding v8 (Unknown Primary Tumor cN3 TNM Finding v8)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a contrast agent composed of hyperpolarized xenon Xe 129 gas (HP129Xe), with potential usage in diagnostic nuclear magnetic resonance (NMR)-based imaging (MRI). Upon inhalation, the hyperpolarized xenon 129 gas is distributed throughout the lungs. MRI, immediately following HP129Xe administration, allows for the visualization of lung structures based on the distribution pattern of the gas. This may aid in the diagnosis of certain lung abnormalities. Hyperpolarization of Xe 129 enhances NMR signals and thus improves imaging and assessment of lung function.\nConcepts: Congenital Arthromyodysplasias (Congenital anomaly of bone and joint)\tMICRO RNA 150 (Gene or Genome)\tAKAP 100 (Adaptor Proteins, Signal Transducing)\thyperpolarized xenon-129 (Indicator, Reagent, or Diagnostic Aid)\tIgM receptor activity (immunoglobulin receptor activity)", + "output": "hyperpolarized xenon-129 (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: something described as discrete mass(es) without leptomeningeal and/or CSF involvement.\nConcepts: IGG, FITC, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tRhodesia, Northern (Africa, Southern)\tSuppuration (Infection)\tvirility (Organism Attribute)\tRetinoblastoma pM1d TNM Finding v7 (Finding)", + "output": "Retinoblastoma pM1d TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as process involving the binding of antisera to a matrix, washing, and release of purified antibodies for use in blood donor screening or in vitro diagnostics.\nConcepts: Selective Washing (Irrigation)\tchemoprevention (Therapeutic or Preventive Procedure)\tGlutamic Acid Decarboxylase 1 (Laboratory Procedure)\tsodium/excitatory glutamate symporter activity (amino acid:sodium symporter activity)\tPolyclonal Antisera Purification (Laboratory Procedure)", + "output": "Polyclonal Antisera Purification (Laboratory Procedure)" + }, + { + "input": "Definition: cough quality described as a cough that does not produce phlegm or mucus. []\nConcepts: antibody Borrelia burgdorferi IgG (Lyme IgG Test)\tNonproductive cough (Lung)\tBromoviridae (Bacterial, insect, plant AND/OR other virus)\tSynthetic Vaccines (Pharmacologic Substance)\tPerinuclear Halo Present (Finding)", + "output": "Nonproductive cough (Lung)" + }, + { + "input": "Definition: Phenomenon or Process described as undesired sound, especially a random mix of different frequencies.\nConcepts: regulation of system process (Biologic Function)\tnegative regulation of endothelial cell chemotaxis (negative regulation of chemotaxis)\tPancreatic Elastase 1 (Protein or Enzyme Type Measurement)\tNOISE (Phenomenon or Process)\tupregulation of cyanophore differentiation (positive regulation of pigment cell differentiation)", + "output": "NOISE (Phenomenon or Process)" + }, + { + "input": "Definition: R [Preparations] described as a pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.\nConcepts: Decreased adenosylcobalamin (Finding)\tAcido risedronico (R [Preparations])\tHydrate, Silica (Acids, Noncarboxylic)\tAbnormal feet morphology (Deformity of limb)\tnarcissism (Mental or Behavioral Dysfunction)", + "output": "Acido risedronico (R [Preparations])" + }, + { + "input": "Definition: Tuberculosis described as tuberculosis disease that is caused by a pre-extensively drug-resistant strain of Mycobacterium tuberculosis.\nConcepts: POSTERIOR FOSSA NEOPL (Neoplastic Process)\tProtein Kinase C, Iota wt Allele (PRKCI gene)\tGLOBULE (Potency Unit)\tFoetal tachycardia (Rate and rhythm disorders NEC)\tPre-XDR-TB (Tuberculosis)", + "output": "Pre-XDR-TB (Tuberculosis)" + }, + { + "input": "Definition: Event described as a situation when a procedure or operation involving use of medical device is performed without required level of care, supervision, or constant observation by a person who is qualified and knowledgeable regarding the device operation and safety procedures.\nConcepts: pN1 Rectal Cancer v6 (Colorectal Cancer Pathologic Regional Lymph Nodes TNM Finding v6)\tORAL LYOPHILISATE (Solid Dose Form)\tFACT-Taxane Version 4 - I Am Able to Work (FACT-Taxane Version 4 Questionnaire Question)\tDay Times mole Per Liter Per Milligram Per Gram (Quantitative Concept)\tDevice Operation Unattended (Event)", + "output": "Device Operation Unattended (Event)" + }, + { + "input": "Definition: soft tissue described as membranous layer which consists of collagenous bundles and fibroblasts that are arranged in multiple sheets or lamellae. Eaxmples: aponeurosis of nasalis, palatine aponeurosis, bicipital aponeurosis.\nConcepts: regulation of filamentous growth of a population of unicellular organisms in response to starvation (regulation of filamentous growth of a population of unicellular organisms)\tWD4D2 4 (WHODAS 2.0 12 24-item Version Interviewer-administered Questionnaire Question)\tendocardial endothelium development (endothelium development)\tNoc2p-Noc3p complex location (Cell Component)\taponeurosis (Membranous layer)", + "output": "aponeurosis (Membranous layer)" + }, + { + "input": "Definition: Ear, nose and throat disorder described as pathological processes that affect voice production, usually involving VOCAL CORDS and the LARYNGEAL MUCOSA. Voice disorders can be caused by organic (anatomical), or functional (emotional or psychological) factors leading to DYSPHONIA; APHONIA; and defects in VOICE QUALITY, loudness, and pitch.\nConcepts: carboxylic acid transmembrane transporter activity (organic anion transmembrane transporter activity)\t10^6U/mL (Quantitative Concept)\tpenetration of cumulus mass (multicellular organismal reproductive process)\tSyndromes, Aortic Arch (Disease or Syndrome)\tSECTION 2-9 VOICE DISORDERS (Neurologic Manifestations)", + "output": "SECTION 2-9 VOICE DISORDERS (Neurologic Manifestations)" + }, + { + "input": "Definition: something described as melanoma of the conjunctiva with local invasion.\nConcepts: JAW RELAT RECORD (Laboratory or Test Result)\tMelanoma of the Conjunctiva cT3 TNM Finding v7 (Finding)\tAbnormality of pancreas physiology (Abnormality of the pancreas)\t11C-Acetate (Radioconjugate)\tCollection Time (Specimen characteristics)", + "output": "Melanoma of the Conjunctiva cT3 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Type of graft described as transplant comprised of an individual's own tissue, transferred from one part of the body to another.\nConcepts: Neuropiles (Cell Component)\tfirst aids (Crisis Management)\tHave Problem with Sleep (Clinical or Research Assessment Question)\tAutograft -RETIRED- (Tissue Grafts)\tAgenesis of the cerebral white matter (Aplasia/Hypoplasia of the cerebral white matter)", + "output": "Autograft -RETIRED- (Tissue Grafts)" + }, + { + "input": "Definition: Oncology drugs described as a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.\nConcepts: 2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl- (Pharmacologic Substance)\tseed development (reproductive structure development)\tExcimer phototherapeutic keratectomy (Refractive keratoplasty)\tDrugs, Histaminergic (Neurotransmitter Agents)\tBladder Cancer pT2a TNM Finding v7 (Bladder Cancer pT2 TNM Finding v7)", + "output": "2-Pyridinecarboxamide, 4-(4-((((4-chloro-3-(trifluoromethyl)phenyl)amino)carbonyl)amino)phenoxy)-N-methyl- (Pharmacologic Substance)" + }, + { + "input": "Definition: Pulmonary function tests described as the energy dissipated relative to the elastic energy stored in the tissue in a P-V cycle. Fredberg, J.J., Stamenovic, D. (1 December 1989). On the Imperfect Elasticity of Lung Tissue. Journal of Applied Physiology, Vol. 67. Retrieved from https://owl.english.purdue.edu/owl/resource/560/10/\nConcepts: AIDS-Related Retinopathy (Disease or Syndrome)\thost organelle outer membrane (host outer membrane)\tESCRT III complex (Cell Component)\tTissue Hysteresivity (Diagnostic Procedure)\tTablet with Sensor (Tablet Dosage Form)", + "output": "Tissue Hysteresivity (Diagnostic Procedure)" + }, + { + "input": "Definition: Auditory system hereditary disorder described as a rare genetic developmental defect during embryogenesis with characteristics of various ophthalmic anomalies (including congenital microphthalmia, microcornea, cataract, anterior segment dysgenesis, ocular coloboma and early onset rod-cone dystrophy) and abnormal external ears (low-set pinna with crumpled helix, narrow intertragic incisure, abnormal bridge connecting the crus of the helix and the anthelix, narrow external acoustic meatus and lobule aplasia). There is evidence the disease is caused by homozygous mutation in the HMX1 gene on chromosome 4p16.\nConcepts: oculoauricular syndrome, Schorderet type (Auditory system hereditary disorder)\tGrade 5 Neonatal Sinus Bradycardia (Finding)\tWaterproof Cloth Tapes (Medical Device)\tPituitary Gland Surgery Scissors (Medical Device)\tMALDI-MS (Laboratory Procedure)", + "output": "oculoauricular syndrome, Schorderet type (Auditory system hereditary disorder)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of parathyroid carcinoma, following the rules of the TNM AJCC v8 classification system as they pertain to distant metastases.\nConcepts: Parathyroid Carcinoma Clinical Distant Metastasis TNM Finding v8 (Finding)\tAbnormal urine output (Abnormality of renal excretion)\tbiotin synthase activity (sulfurtransferase activity)\tLBR Saliva Substitute (Pharmacologic Substance)\tVulval (External genitalia)", + "output": "Parathyroid Carcinoma Clinical Distant Metastasis TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as insulin-like growth factor-binding protein 6 (240 aa, ~25 kDa) is encoded by the human IGFBP6 gene. This protein plays a role in insulin-like growth factor binding.\nConcepts: Study of Osteoporotic Fractures [SOF] Index (Intellectual Product)\trRNA methylation (Genetic Function)\tagent units of measure (Quantitative Concept)\tURI1, Prefoldin Like Chaperone Gene (Gene or Genome)\tInsulin-Like Growth Factor-Binding Protein 6 (Biologically Active Substance)", + "output": "Insulin-Like Growth Factor-Binding Protein 6 (Biologically Active Substance)" + }, + { + "input": "Definition: heterocycle biosynthetic process described as the chemical reactions and pathways resulting in the formation of (-)-pinoresinol.\nConcepts: Deficiency of glucose-6-phosphate dehydrogenase (Disease or Syndrome)\t(-)-pinoresinol formation ((-)-pinoresinol metabolic process)\tt(16;21)(q24;q22) (Cell or Molecular Dysfunction)\tPain associated with defaecation (Feces/motions - symptoms)\twar/peace (Idea or Concept)", + "output": "(-)-pinoresinol formation ((-)-pinoresinol metabolic process)" + }, + { + "input": "Definition: Endocrine gland operation described as surgical removal or chemical destruction of the hypophysis, or pituitary gland.\nConcepts: Fatigue Subordinate Domain (Intellectual Product)\tindole and derivative metabolism (Molecular Function)\tMK-8242 (MDM2 Inhibitor)\tRemoval;pituitary gland (Operations on other endocrine glands)\tbillion organisms/gram (Unit of Arbitrary Substance Concentration)", + "output": "Removal;pituitary gland (Operations on other endocrine glands)" + }, + { + "input": "Definition: something described as any elsewhere undefined Oriental therapy, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Undefined Oriental therapy narrative required (Therapeutic or Preventive Procedure)\tMacrophage, Bone Marrow-Derived (HEMATOPOIETIC AND RETICULOENDOTHELIAL SYSTEMS: GENERAL TERMS)\tNon-Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma (Neoplastic Process)\toxidoreductase activity, oxidizing metal ions with flavin as acceptor (oxidoreductase activity, oxidizing metal ions)\tJejunums (Body Part, Organ, or Organ Component)", + "output": "Undefined Oriental therapy narrative required (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Human leukocyte antigen phenotyping described as the identification of the type of human leukocyte antigen, class II, antigen-D-related (HLA-DR), in a biological specimen.\nConcepts: HLADRAGT (Human leukocyte antigen phenotyping)\ttumor testicular (Neoplasm of the male external genitalia)\tCerebrospinal fluid shunt operation (surgery for shunting cerebrospinal fluid)\tmucinous (Disease Morphology Qualifier)\tFurosemide product (Sulfonamide diuretic)", + "output": "HLADRAGT (Human leukocyte antigen phenotyping)" + }, + { + "input": "Definition: something described as membrane cofactor protein (392 aa, ~44 kDa) is encoded by the human CD46 gene. This protein is involved in the classical complementation pathway, pathogen binding, fertilization and T-cell differentiation.\nConcepts: Measurement of methaemoglobin (Protein measurement)\tAntigen Defined By Monoclonal Antibody TRA-2-10 (Binding Proteins)\tAdrenergic beta Agonist (Adrenergic Antagonists)\timmune complex hemolytic anemia (Disease or Syndrome)\tDecreased protein levels in blood (Serum/plasma protein finding)", + "output": "Antigen Defined By Monoclonal Antibody TRA-2-10 (Binding Proteins)" + }, + { + "input": "Definition: Medical Device described as auditory stimulators designed to apply mechanical (i.e., vibratory) stimuli containing sound information to the middle ear structures. These devices consist of a fully implantable device which includes a processor that obtains the sound signal, transduces it into electrical signals and, after processing the signal, turns it back into vibrations that are delivered to the middle ear ossicles. Two types of vibratory stimulators are available: (1) Stimulators that pick the natural vibrations of the incus (i.e., without any microphone) resulting from external sound and reintroduce them after processing on the stapes while surgically disarticulating the natural chain of sound transmission in the ossicles; and (2) stimulators that include a microphone that is implanted close to the skin to pick up the external sounds and convert them into electrical signals; after processing the electrical signals they are turned back into vibrations which are delivered to the ossicles. Middle-ear auditory mechanical stimulators are intended for patients suffering from a moderate to severe deafness (typically 40 to 90 dB hearing loss).\nConcepts: Alpha tumour necrosis factor (Laboratory Procedure)\tMucin 4 (Intracellular Signaling Peptides and Proteins)\tChecklist (List)\tVibration Auditory Stimulators (Stimulators, Mechanical)\tPolydactyly (disorder) [Ambiguous] (Perodactylia)", + "output": "Vibration Auditory Stimulators (Stimulators, Mechanical)" + }, + { + "input": "Definition: something described as sounds having similar characteristics and functional properties of natural speech but which are made by means other than natural vocalization mechanisms (e.g., computer-generated speech sounds).\nConcepts: nematoblast (spermatogenesis stage I)\tCardiac rhythm (Tissue Perfusion: Cellular)\tSurvey, Library (Library Science)\t11p12-p11.2 (Chromosome band)\tSynthetic Speech (Mechanical Speech Processing)", + "output": "Synthetic Speech (Mechanical Speech Processing)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 865 of the coding sequence of the EGFR gene where guanine has been mutated to adenine.\nConcepts: NM 005228.3:c.865G>A (Cell or Molecular Dysfunction)\tLeft Renal Artery (Body Part, Organ, or Organ Component)\tEpithelial reticular cell of thymus (Cell)\tPlace Identifier (Intellectual Product)\tALL, L3 pediatric (Childhood Leukemia)", + "output": "NM 005228.3:c.865G>A (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Flexion contracture of proximal interphalangeal joint of finger described as chronic loss of joint motion of the proximal interphalangeal joint of the 3rd finger due to structural changes in non-bony tissue.\nConcepts: Ventilation Monitors (Monitors, Physiologic, Respiration)\tAnalyzers, Physiologic, Vascular Function (Analyzers, Physiologic)\tElectronic System Deployment (Deploy)\tCamptodactyly of the 3rd finger (Anatomical Abnormality)\tacetaminophen/caffeine/pyrilamine (acetaminophen / caffeine)", + "output": "Camptodactyly of the 3rd finger (Anatomical Abnormality)" + }, + { + "input": "Definition: Abnormal ejaculation described as the emission of semen and seminal fluid into the bladder instead of through the penis during orgasm.\nConcepts: aurum iodatum/gold iodide (Homeopathic remedies letter A)\tsperm plasma membrane breakdown (membrane disassembly)\tENZYME IMMUNOASSAY, CANNABINOIDS (Medical Device)\tRetrograde ejaculation (Orgasmic Disorder)\tmcg/mg (Mass per unit mass)", + "output": "Retrograde ejaculation (Orgasmic Disorder)" + }, + { + "input": "Definition: Neoplastic Process described as a malignant neoplasm that arises from a site other than the bone marrow and lymphoid tissue.\nConcepts: Heart Rate, Decreased (Finding)\tmercury poison (Mercury Poisoning)\tControlled Hypotension (Therapeutic or Preventive Procedure)\tNon-Hematologic Malignancy (Malignant Neoplasms)\tWheelchair Tire Device (Manufactured Object)", + "output": "Non-Hematologic Malignancy (Malignant Neoplasms)" + }, + { + "input": "Definition: Adverse Event by Type described as an adverse reaction, whose nature, severity, specificity, or outcome is not consistent with the term or description used in the applicable product information. [ICH E2] See also adverse drug reaction.\nConcepts: UAE (Finding)\tGlycols (Glycol and glycol derivative)\tIn-facility simple subsequent nutrition intake 10 minutes (Health Care Activity)\tAVRT- AV re-entrant tachy (AV nodal tachycardia)\tMidshaft hypospadias (Anatomical Abnormality)", + "output": "UAE (Finding)" + }, + { + "input": "Definition: Organic Chemical described as a glyceryl guaiacolate with expectorant effects. Guaifenesin increases respiratory tract mucus secretions, acts as an irritant to gastric vagal receptors and recruits efferent parasympathetic reflexes that cause glandular exocytosis. This agent reduces the viscosity of mucus secretion by reducing adhesiveness and surface tension as well as increasing hydration of mucus. Guaifenesin promotes the efficiency of the mucociliary mechanism important in removing accumulated secretions from the upper and lower airway.\nConcepts: Cooperation, International (social cooperation)\talpha-Glyceryl guaiacol ether (narcotic antitussives)\tFree upper limb (Free limb)\tLipaemia (Finding)\tQS-HAQ-DI TESTCD (Intellectual Product)", + "output": "alpha-Glyceryl guaiacol ether (narcotic antitussives)" + }, + { + "input": "Definition: Disease or Syndrome described as herniation of spinal cord tissue and meninges through a defect in the sacral region of the vertebral column. The protrusion of the tissue is flush with the level of the skin surface.\nConcepts: Orientation (Property or Attribute)\tSacral Myelocele (Disease or Syndrome)\tbiosynthesis of protein-protein cross-link via L-lysine 5-imidazolinone glycine (peptidyl-lysine modification)\tNon-material physical anatomical entity (Physical anatomical entity)\tHaemophilus parainfluenzae (Hemophilus)", + "output": "Sacral Myelocele (Disease or Syndrome)" + }, + { + "input": "Definition: Premenstrual Syndrome (PMS) Severity described as an unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the back. []\nConcepts: Myeloid Proliferation Index (Laboratory Procedure)\tranitidin (R [Preparations])\tLISTERIA IVANOVII (Bacterium)\tbackpain (Chest Pain)\tBone Marrow Core Biopsy Sample (Biopsy sample)", + "output": "backpain (Chest Pain)" + }, + { + "input": "Definition: something described as urethral cancer with no regional lymph node metastasis.\nConcepts: E-mail (Telecommunication Address)\tGlobal Response Score (Research or Clinical Assessment Tool)\tEQ-5D-3L Questionnaire Question (Clinical or Research Assessment Question)\tUrethral Carcinoma pN0 TNM Finding v8 (Urethral Cancer Pathologic Regional Lymph Nodes TNM Finding v8)\tProgressive myoclonus epilepsy type 3 (Myoclonic Epilepsies, Progressive)", + "output": "Urethral Carcinoma pN0 TNM Finding v8 (Urethral Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: positive regulation of MAP kinase activity described as the initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK).\nConcepts: Unit/Square Meter/Minute (Arbitrary Unit of Substance Rate)\tASEX-Female Version - Sex Drive (ASEX-Female Version Questionnaire Question)\tShort innermost 2nd toe bone (Short phalanx of the 2nd toe)\tactivation of MAP2K activity (activation of protein kinase activity)\tOther Toxicity Studies: Dependence (Toxicology: Other Toxicity Studies)", + "output": "activation of MAP2K activity (activation of protein kinase activity)" + }, + { + "input": "Definition: something described as a pathologic finding about one or more characteristics of nasopharyngeal cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.\nConcepts: Number of Days from Date of Initial Cancer Diagnosis to Date of New Tumor Event after Initial Treatment (Numbers)\tintercalated periaqueductal gray (Body Part, Organ, or Organ Component)\tNasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8 (Finding)\tmandatoryIndicator (Indicator)\tInterslice Distance Measurement (Quantitative Concept)", + "output": "Nasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Finding described as the maximum volume of air that can be exhaled after slow maximum inhalation.\nConcepts: Duodenal Extraskeletal Osteosarcoma (Malignant neoplasm of duodenum)\tmutL (E. coli) homolog 3 (DNA Repair Gene)\tDiaphyseal medullary stenosis with malignant fibrous histiocytoma (Disease or Syndrome)\tProstate Phyllodes Neoplasm (Prostatic Neoplasms)\tslow vital capacity (Pulmonary function tests)", + "output": "slow vital capacity (Pulmonary function tests)" + }, + { + "input": "Definition: something described as gastric cancer without regional lymph node metastasis. Note: A designation of pN0 should be used if all examined lymph nodes are negative, regardless of the total number removed and examined.\nConcepts: GTF2E2 (Gene or Genome)\tGastric Cancer pN0 TNM Finding v7 (Finding)\ttotal artificial organ (Therapeutic or Preventive Procedure)\tUKR (USSR)\tSphygmomanometers, Electronic, Automatic, Auscultatory (Medical Device)", + "output": "Gastric Cancer pN0 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as merino sheep breed group\nConcepts: hydroxylysine metabolic process (cellular modified amino acid metabolic process)\tMerino (Domestic Sheep)\tresponse to signal involved in mitotic cell cycle spindle assembly checkpoint (Cell Function)\tSite Personnel Supporting Information (Intellectual Product)\tprofessional development (Development)", + "output": "Merino (Domestic Sheep)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of synaptic vesicle uncoating.\nConcepts: Matthiola graeca / giliflower (Pharmacologic Substance)\tEicosadienoic Acid (Very long chain fatty acid)\tupregulation of synaptic vesicle coat depolymerization (regulation of synaptic vesicle uncoating)\tColorectal High Grade B-Cell Lymphoma, Not Otherwise Specified (Colorectal Diffuse Large B-Cell Lymphoma)\tPacked Erythrocyte Volume (Complete Blood Count)", + "output": "upregulation of synaptic vesicle coat depolymerization (regulation of synaptic vesicle uncoating)" + }, + { + "input": "Definition: something described as specifies whether the laboratory test result values should be excluded from the statistical analysis.\nConcepts: Exclude Laboratory Test Data From Statistics Indicator (Finding)\tvitamin B6 biosynthetic process from pyridoxamine (Molecular Function)\tStromelysin-1 (Matrix Metalloproteinases)\tMeningeal Cell Count (Cell Count)\t20q11.2 (Cell Component)", + "output": "Exclude Laboratory Test Data From Statistics Indicator (Finding)" + }, + { + "input": "Definition: something described as psoriasis Area and Severity Index - Trunk (T): Sum = E + I + D.\nConcepts: FIQR01-Change Bed Sheets (FIQR Questionnaire Question)\t3 Plus Score (WHO Mycobacterium Quantitation Scheme)\tfamilial hypoplastic anemia (Genetic Diseases, Inborn)\tHereditary fibrosing poikiloderma, tendon contractures, myopathy, pulmonary fibrosis syndrome (Hereditary Connective Tissue Disorder)\tPASI0111 (PASI Clinical Classification Question)", + "output": "PASI0111 (PASI Clinical Classification Question)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a chemotherapy regimen consisting of melphalan that may be used in the treatment of ovarian, fallopian tube and primary peritoneal cancers.\nConcepts: Alkeran Regimen (Regimen Used to Treat Malignant Peritoneal Neoplasm)\tProstate Carcinoma cT3 TNM Finding v8 (Prostate Cancer Clinical Primary Tumor TNM Finding v8)\tDAD - Dress Himself/Herself Completely (DAD Questionnaire Question)\tVisfatin (Enzyme)\tSIQ - Thought Life Was Not Worth Living (SIQ Questionnaire Question)", + "output": "Alkeran Regimen (Regimen Used to Treat Malignant Peritoneal Neoplasm)" + }, + { + "input": "Definition: General adjectival modifier described as morphologic changes that are persistent or long standing, superimposed with areas of acute change.\nConcepts: alpha-TEA cpd (ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS)\tSOAPR124 (SOAPP-R Questionnaire Question)\tMATERIAL, EXTERNAL AESTHETIC RESTORATION, NO ADHESIVE (Medical Device)\tChronic Active (General adjectival modifier)\tchemotherapies (Antineoplastic Agents)", + "output": "Chronic Active (General adjectival modifier)" + }, + { + "input": "Definition: Hydrops Fetalis described as fluid accumulation in multiple fetal anatomic cavities attributable to a maternal immune response against fetal blood cell antigens.\nConcepts: Hydrops fetalis due to isoimmunisation (Hydrops Fetalis)\tMyelin protein (Nerve Tissue Proteins)\tSumatriptan succinate [dup] (Organic Chemical)\tpositive regulation of interleukin-7 secretion (Cell Function)\tNeurexin IV Gene (CNTNAP1 gene)", + "output": "Hydrops fetalis due to isoimmunisation (Hydrops Fetalis)" + }, + { + "input": "Definition: Subdivision of fibrous skeleton of heart described as subdivision of fibrous skeleton of heart which connects the anterior filum coronarium to the posterior filum coronarium of tricuspid valve anulus.\nConcepts: Lumbosacral nerve plexus (Structure of non-autonomic peripheral nerve of the trunk)\tTFIID (Protein or Riboprotein Complex)\tcentrosomal protein 350 (Gene or Genome)\tInterfilar connective tissue of tricuspid valve (Tissue)\t((3R)-3-((2-amino-6-oxo-3H-purin-9-yl)methyl)-4-hydroxy-butyl) (2S)-2-amino-3-methyl-butanoate (DNA Polymerase Inhibitors)", + "output": "Interfilar connective tissue of tricuspid valve (Tissue)" + }, + { + "input": "Definition: Fallopian Tube Cancer pT2 TNM Finding v7 described as fallopian tube cancer with extension and/or metastasis to the uterus and/or ovaries.\nConcepts: PDQUALIF - Parkinson's Symptoms (PDQUALIF Questionnaire Question)\tFallopian Tube Cancer pT2a TNM Finding v7 (Finding)\tSpondylocostal dysostosis, hypospadias, intellectual disability syndrome (Hereditary disorder of musculoskeletal system)\tUnclassified (General adjectival modifier)\tBRCA2 Mutation Carrier (Mutation Carrier)", + "output": "Fallopian Tube Cancer pT2a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as a term that refers to the staging of penile carcinoma according to the American Joint Committee on Cancer, 6th edition.\nConcepts: Bone Caps (Medical Device)\tColorimetry (Laboratory Procedure)\tDNA analysis (Cytogenetic procedure)\tPenile Carcinoma by AJCC v6 Stage (Neoplastic Process)\tRamus superficialis (Structure of cervical artery)", + "output": "Penile Carcinoma by AJCC v6 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Sterilization Process Challenge Packs described as devices consisting of a chemical sterilization process indicator contained within packaging that functions as a barrier to penetration of the sterilizing agent. Chemical process challenge packs may be supplied commercially or prepared at the healthcare facility. Chemical process challenge pack packaging is typically designed to provide a challenge to sterilizing agent penetration equal to or greater than the challenge posed by the most difficult item routinely processed at the facility.\nConcepts: PMMSA (Protozoan Proteins)\tupregulation of interleukin-5 production (positive regulation of cytokine production)\t2-oxoglutarate decarboxylase activity (Molecular Function)\tSterilization Process Challenge Packs, Chemical (Manufactured Object)\tXilamide (Pharmacologic Substance)", + "output": "Sterilization Process Challenge Packs, Chemical (Manufactured Object)" + }, + { + "input": "Definition: transmembrane signaling receptor activity described as combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.\nConcepts: Deviation of the hallux (Anatomical Abnormality)\topsonin receptor activity (Molecular Function)\tMonoterpenes, Acyclic (Monoterpenes)\tasparagine transmembrane import into vacuole (Cell Function)\tPGH 02 (Biologically Active Substance)", + "output": "opsonin receptor activity (Molecular Function)" + }, + { + "input": "Definition: Abnormal renal function described as an abnormally increased or reduced amount of fluid filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time.\nConcepts: MUC1 Peptide-Poly-ICLC Vaccine (Pharmacologic Substance)\tPicibanil (Chemo Immunostimulant Adjuvant)\tED208 6 (Expanded DRS-PI Survivor Version Questionnaire Question)\tFocal bilateral motor seizure (Epilepsy, Partial, Motor)\tGlomerular filtration rate abnormal (Kidney Function Tests)", + "output": "Glomerular filtration rate abnormal (Kidney Function Tests)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a type of breast reconstruction in which blood vessels called deep inferior epigastric perforators (DIEP), and the skin and fat connected to them are removed from the lower abdomen and used for reconstruction. Muscle is left in place.\nConcepts: Barcelona Clinic Liver Cancer Stage 0 Adult Hepatocellular Carcinoma (Adult Hepatocellular Carcinoma)\tAdult-onset immunodeficiency with acquired anti-interferon-gamma autoantibodies (Adult-onset immunodeficiency)\tDIEP Flap (Therapeutic or Preventive Procedure)\tatypical glandular cells of undetermined significance (Cell or Molecular Dysfunction)\tPowder and solvent for injection suspension (Type of drug preparation)", + "output": "DIEP Flap (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: something described as devices in which blood and oxygen are separated by a semipermeable membrane, generally of Teflon or polypropylene, across which gas exchange occurs. The membrane may be arranged as a series of parallel plates or as a number of hollow fibers; in the latter arrangement, the blood may flow inside the fibers, which are surrounded by gas, or the blood may flow outside the fibers and the gas inside the fibers.\nConcepts: Liquid Chromatography Mass Spectrometry (Liquid Chromatography)\tMembrane Oxygenators (Medical Device)\t17q22-qter (Chromosome band)\tCHEBI ID (Conceptual Entity)\tpositive regulation of beta 2 integrin biosynthesis (Cell Function)", + "output": "Membrane Oxygenators (Medical Device)" + }, + { + "input": "Definition: Computational Technique described as a process of finding model parameters that give a best fit of the model to the data points from a system.\nConcepts: antimicrotubule agent (Pharmacologic Substance)\tRibociclib/Fulvestrant Regimen (Regimen Used to Treat Breast Carcinoma)\tBreast Carcinoma pTis (DCIS) TNM Finding v8 (Breast Cancer Pathologic Primary Tumor TNM Finding v8)\tNonabsorbable Periodontal Regeneration Membrane Implants (Medical Device)\tParameter Identification (Computational Technique)", + "output": "Parameter Identification (Computational Technique)" + }, + { + "input": "Definition: Acute Myeloid Leukemia, M1 described as an acute myeloid leukemia without maturation occurring in children.\nConcepts: IA-2 (Protein Tyrosine Phosphatase)\tQT Interval, Aggregate (Quantitative Concept)\tPediatric Acute Myeloblastic Leukemia without Maturation (Neoplastic Process)\tTPOR c.1543 1544TGG>AAA (Cell or Molecular Dysfunction)\tsolute carrier family 5 member 2 (Transport Protein Gene)", + "output": "Pediatric Acute Myeloblastic Leukemia without Maturation (Neoplastic Process)" + }, + { + "input": "Definition: Gene or Genome described as human PPID wild-type allele is located in the vicinity of 4q31.3 and is approximately 14 kb in length. This allele, which encodes peptidyl-prolyl cis-trans isomerase D protein, is involved in protein folding.\nConcepts: CYPD (Gene or Genome)\tGrade 3 Forced expiratory volume decreased (Forced Expiratory Volume Decreased, CTCAE)\tdexanabinol (Pharmacologic Substance)\tMotivation Score 6 (Intellectual Product)\tSmoothened, Frizzled Class Receptor Gene Mutation (Cell or Molecular Dysfunction)", + "output": "CYPD (Gene or Genome)" + }, + { + "input": "Definition: Non-site specific procedural complications described as an immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.\nConcepts: Welander distal myopathy, Swedish type (Autosomal dominant hereditary disorder)\tRefractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified (Neoplastic Process)\tCTRAG (Microbiology procedure)\tProstate Cancer Pathologic Distant Metastasis TNM Finding v6 (Finding)\tRejection, Transplant (Immune disorders NEC)", + "output": "Rejection, Transplant (Immune disorders NEC)" + }, + { + "input": "Definition: something described as a recombinant form of neurotrophic growth factor that regulates the development and maintenance of motor neurons expressing trk B receptor tyrosine kinase, with potential use in neurodegenerative disorders.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II, DQ Loci (IVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class II)\tPaired Box Gene 8 Gene (Gene or Genome)\tmethionyl human brain-derived neurotrophic factor, recombinant (Amino Acid, Peptide, or Protein)\twing disc pattern formation (imaginal disc pattern formation)\tVectibix Regimen (Therapeutic or Preventive Procedure)", + "output": "methionyl human brain-derived neurotrophic factor, recombinant (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Tumor stage finding described as clinical stage 0 is used to record the tumor stage based on clinical assessment (not pathological assessment). A patient with stage 0 would not have invasive cancer.\nConcepts: Early Post-Partum Recovery (Organism Function)\tUNHCR (Organization)\tClinical stage 0 (Tumor stage finding)\tLactobacillus GG (Bacterium)\tschinopsis balansaei/red que (Organic Chemical)", + "output": "Clinical stage 0 (Tumor stage finding)" + }, + { + "input": "Definition: salivary nucleus development described as the process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure.\nConcepts: inferior salivary nucleus development (salivary nucleus development)\tpositive regulation of actin filament bundle convergence involved in mitotic contractile ring assembly (Cell Function)\tWD Repeat Domain 22 Gene (DCAF5 gene)\theptadec-1-ene anabolism (Molecular Function)\teffector-mediated modulation of host defenses by symbiont (Organism Function)", + "output": "inferior salivary nucleus development (salivary nucleus development)" + }, + { + "input": "Definition: Other Diagnostic Nuclear Medicine Procedures described as an imaging technique for measuring the gamma radiation produced by collisions of electrons and positrons (anti-electrons) within living tissue. In positron emission tomography (PET), a subject is given a dose of a positron-emitting radionuclide attached to a metabolically active substance. A scanner reveals the tissue location of the metabolically-active substance administered.\nConcepts: regulation of heme formation (Molecular Function)\tantipodal cell differentiation (Cell Differentiation process)\tPOSITRON EMISS TOMOGR (Imaging procedures NEC)\tPODCI257 (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tup-regulation of ornithine degradation (positive regulation of cellular catabolic process)", + "output": "POSITRON EMISS TOMOGR (Imaging procedures NEC)" + }, + { + "input": "Definition: something described as any process involved in the carrying out of an immune response by a basophil.\nConcepts: basophil mediated immunity (myeloid leukocyte mediated immunity)\tsepiapterin reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tHIV and HIV Genome (Classification)\torganizational behavior (Organizations & Organizational Behavior)\tProlapse of intestinal stoma (Ptosis)", + "output": "basophil mediated immunity (myeloid leukocyte mediated immunity)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Word recall task word average score of trials 1, 2, 3.\nConcepts: Meningitis due to E. coli (Bacterial meningitis due to Gram-negative bacteria)\tADCRL (Intellectual Product)\tRGD Domain (Amino Acid, Peptide, or Protein)\tglyoxysome (peroxisome)\tGrade 1 Anorexia (Anorexia, CTCAE)", + "output": "ADCRL (Intellectual Product)" + }, + { + "input": "Definition: something described as a response indicating that an individual's pattern of bowel movements occasionally causes or caused them some discomfort.\nConcepts: Grade 2 Intraoperative Splenic Injury, CTCAE (Finding)\tPerformedClinicalResult (Finding)\tdendrite extension (Cell Function)\tFIHPT - familial isolated hyperparathyroidism (Hereditary Diseases)\tBowel Pattern Occasionally Causes Some Discomfort (Intellectual Product)", + "output": "Bowel Pattern Occasionally Causes Some Discomfort (Intellectual Product)" + }, + { + "input": "Definition: something described as a medulloblastoma composed of sheets of large cells mixed with cells characterized by marked nuclear pleomorphism and high mitotic activity.\nConcepts: Large Cell/Anaplastic Medulloblastoma (Neoplastic Process)\tPain Relief (Therapeutic or Preventive Procedure)\tSorting Nexin-Associated Golgi Protein 1 (Carrier Proteins)\tMorvan Choreas (Neuromuscular Manifestations)\tBlood Pheresis Sets, Closed (Medical Device)", + "output": "Large Cell/Anaplastic Medulloblastoma (Neoplastic Process)" + }, + { + "input": "Definition: Spatial Concept described as a setting outside the clinic or a comparable health care facility, e.g. a doctor's office, the subject's home or workplace, a school, a public park, or a restaurant.\nConcepts: Inhibitors, Glycoside Hydrolase (Enzyme Inhibitors)\tCTDSP2 gene (Protein Serine/Threonine Phosphatase Gene)\tRete Ovarii Neoplasm (Neoplastic Process)\t4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)- (Penicillanic Acid)\tFIELD (Location)", + "output": "FIELD (Location)" + }, + { + "input": "Definition: something described as a device designed to open an electrical circuit when it becomes overloaded.\nConcepts: congenital poikiloderma (Disease or Syndrome)\tEmbryonic stage (Temporal Concept)\tcell proliferation involved in heart valve morphogenesis (cell proliferation involved in heart morphogenesis)\tCircuit Breaker Device (Device Component or Accessory)\tSyndromic recessive X-linked ichthyosis (Disease or Syndrome)", + "output": "Circuit Breaker Device (Device Component or Accessory)" + }, + { + "input": "Definition: drug catabolic process described as the chemical reactions and pathways resulting in the breakdown of cordyol C.\nConcepts: Troche Dosing Unit (Quantitative Concept)\tHave you received adequate support from your health care professionals (Intellectual Product)\tIndenes (Organic Chemical)\tCLL Stage IV (Neoplastic Process)\tcordyol C breakdown (secondary metabolite catabolic process)", + "output": "cordyol C breakdown (secondary metabolite catabolic process)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question associated with the FBRSI questionnaire.\nConcepts: Xp22.1 (Cell Component)\tNUT Midline Carcinoma, Family Member 1 Gene Translocation (Cell or Molecular Dysfunction)\thypotonic response (Cell Function)\tFBRSI Questionnaire Question (Clinical or Research Assessment Question)\tAnalytical Procedure Range (Measurement)", + "output": "FBRSI Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Cervix carcinoma described as a carcinoma that arises from the cervix and is caused by human papillomavirus infection.\nConcepts: AVL01036 (Intellectual Product)\tHuman Papilloma Virus Related Cervical Carcinoma (Neoplastic Process)\tGlucose Transport Facilitators (Monosaccharide Transport Proteins)\tActivation, Difficult /Delayed (Finding)\tPatchy sclerosis of 3rd finger phalanx (Patchy sclerosis of finger phalanx)", + "output": "Human Papilloma Virus Related Cervical Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Acinetobacter described as any bacterial organism that can be assigned to the species Acinetobacter junii.\nConcepts: ACINETOBACTER JUNII (Bacterium)\tpeptide pheromone transmembrane export involved in positive regulation of conjugation with cellular fusion (peptide pheromone export by transmembrane transport)\tGrade 4 Pelvic infection (Pelvic Infection, CTCAE)\tMedical Homes (Health Care Activity)\tregulation of cell-cell adhesion involved in gastrulation (regulation of gastrulation)", + "output": "ACINETOBACTER JUNII (Bacterium)" + }, + { + "input": "Definition: Psychosis with origin in childhood described as a neurodevelopmental disorder presenting in early childhood that is characterized by impaired communication, difficulty in social interactions, stereotypic behaviors, and a limited range of interests and activities.\nConcepts: Deletion 7q11.23 (Anomaly of chromosome pair 7)\tAnnuloplasty Ring/Band Implants (Non-Active Implantable Devices)\tHerpes Zoster Ophthalmicus (Trigeminal nerve inflammation)\tKanners Syndrome (Behavioral/psychiatric manifestations)\tPTPT (PTPN2 gene)", + "output": "Kanners Syndrome (Behavioral/psychiatric manifestations)" + }, + { + "input": "Definition: something described as a description of the clinical change to the subject after a non-invasive imaging procedure.\nConcepts: Non-Invasive Imaging Change (Test Result)\tJQ791014 (Intellectual Product)\tinfectious meningitis (Disease or Syndrome)\tmmol/mol creat (Miscellaneous Concentration Unit)\tDETECTOR, LEAK, BLOOD (Detectors, Blood Leakage)", + "output": "Non-Invasive Imaging Change (Test Result)" + }, + { + "input": "Definition: something described as the directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose.\nConcepts: Optic Fissure (Embryonic Structure)\tRecording, Tape (Manufactured Object)\tUDP acetylglucosamine epimerase activity (Molecular Function)\tglucitol transport (polyol transport)\tCSS04-Number of Actual Attempts-P Y (Intellectual Product)", + "output": "glucitol transport (polyol transport)" + }, + { + "input": "Definition: Finding described as a cyst located at the periphery of the meniscus.\nConcepts: ornithine carbamoyltransferase inhibitor activity (Molecular Function)\tHAQ-DI Without VAS - Aid: Wheelchair (HAQ-DI Without VAS Questionnaire Question)\t11q24 (Cell Component)\tcumulus cell differentiation (epithelial cell differentiation)\tMeniscal Cyst (Finding)", + "output": "Meniscal Cyst (Finding)" + }, + { + "input": "Definition: Transcription Regulatory Protein described as POU domain class 2-associating factor 1 (256 aa, ~27 kDa) is encoded by the human POU2AF1 gene. This protein is involved in both the modulation of transcription and humoral immunity.\nConcepts: POU2AF1 protein, human (Transcription Regulatory Protein)\tUDP-Urid diphosphgalact-4-epim (Enzymes)\tcellular response to rotenone (cellular response to drug)\tmitochondrial inner membrane protein insertion complex location (Cell Component)\tDUCTOGRAPHY (Mammography)", + "output": "POU2AF1 protein, human (Transcription Regulatory Protein)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy described as molecular assay reagents intended to identify gene variants associated with dilated cardiomyopathy, a form of cardiomyopathy characterized by ventricular dilation. Genetic variants at multiple loci have been associated with dilated cardiomyopathy. These reagents are intended to detect various types of genetic changes (e.g., deletions, duplications, insertions, single nucleotide polymorphisms) in multiple dilated cardiomyopathy-associated loci simultaneously.\nConcepts: QLES1-Enjoyed Course/Class Work (Intellectual Product)\tIVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy, Dilated (IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy)\tBRACHYTELEPHALANGIC CHONDRODYSPLASIA PUNCTATA (Disease or Syndrome)\tnegative regulation of corticosteroid hormone secretion (Cell Function)\tStage II Appendix Carcinoid Tumor (Neoplastic Process)", + "output": "IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy, Dilated (IVD Panels, Human Genetics, Cardiac Disorder, Cardiomyopathy)" + }, + { + "input": "Definition: Molecular Function described as phenomena and pharmaceutics of compounds that inhibit the function of agonists (DRUG AGONISM) and inverse agonists (DRUG INVERSE AGONISM) for a specific receptor. On their own, antagonists produce no effect by themselves to a receptor, and are said to have neither intrinsic activity nor efficacy.\nConcepts: Hydrolyzers (Embolectomy/thrombectomy catheter)\tIntralobular stroma of lactiferous gland (Right breast)\tbeta-1,6 glucan biosynthesis (Molecular Function)\tLaboratory Shipment Record (Records)\tDRUG ANTAG (Drug Interactions)", + "output": "DRUG ANTAG (Drug Interactions)" + }, + { + "input": "Definition: something described as administration of a pharmaceutical product by atomising or otherwise dissipating it into a fine dispersion of particles in air, directing it such that it comes into contact with the affected area.\nConcepts: regulation of corticotropin secretion (Cell Function)\tSUPPDD (Supplemental Qualifiers Tabulation Dataset)\tCEREBELLAR NEOPL BENIGN (Cerebellar Neoplasms)\tspraying (MOTOR BEHAVIOR AND DISTURBANCES)\tI don't look like myself (Clinical or Research Assessment Question)", + "output": "spraying (MOTOR BEHAVIOR AND DISTURBANCES)" + }, + { + "input": "Definition: something described as a unit of force defined as the force that accelerates a mass of one gram at the rate of one centimeter per second squared. One dyne is equal to 1E-5 Newton and 2.248E-6 pounds of force.\nConcepts: WD6-Care of Household Responsibilities (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)\tSpecify Other MET Intron 13 Mutation (Specify Other MET Mutation)\tDyne (Quantitative Concept)\tAdjacency Matrix (Matrix Array)\tIntralobar nephrogenic rests (Nephrogenic rest)", + "output": "Dyne (Quantitative Concept)" + }, + { + "input": "Definition: Circulation status described as the force of a heart contraction measured by the difference between the diastolic and systolic blood pressure measurements.\nConcepts: IMA201 (Antineoplastic Immune Cell)\tFLJ26216 (EZR gene)\tIPA0219B (Intellectual Product)\tpulse pressure (Vital signs)\tresponse to DDT (response to insecticide)", + "output": "pulse pressure (Vital signs)" + }, + { + "input": "Definition: Cognitive function observations described as process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.\nConcepts: Gleason pattern.primary (Gleason pattern)\tAmputation NOS (removal technique)\tStage IVB Thyroid Gland Undifferentiated (Anaplastic) Carcinoma AJCC v8 (Thyroid Gland Anaplastic Carcinoma by AJCC v8 Stage)\tFAC061-I Have Trouble With My Bowels (Intellectual Product)\tDecision making behaviour (Cognitive function observations)", + "output": "Decision making behaviour (Cognitive function observations)" + }, + { + "input": "Definition: GAD-7 Version 2 Questionnaire Question described as generalized Anxiety Disorder - 7 Version 2 - Feeling afraid as if something awful might happen.\nConcepts: Gene Product Is Element In Pathway (Idea or Concept)\tFormal relationships (Social Behavior)\tGAD02-Feel Afraid/Something Awful Happen (Intellectual Product)\tUnresectable Lung Small Cell Carcinoma (Small cell carcinoma of lung)\tPhosphorothioate Oligonucleotides (Pharmacologic Substance)", + "output": "GAD02-Feel Afraid/Something Awful Happen (Intellectual Product)" + }, + { + "input": "Definition: Lactobacillus described as any bacterial organism that can be assigned to the species Lactobacillus paracasei.\nConcepts: Lactobacillus Paracasei (Lactobacillus casei group)\tLactobacillus casei subsp rhamnosus (L [Preparations])\tMBSEQ (Intellectual Product)\tresponse to serotonin (response to oxygen-containing compound)\tFIQR0113 (FIQR Questionnaire Question)", + "output": "Lactobacillus Paracasei (Lactobacillus casei group)" + }, + { + "input": "Definition: Hydrolase described as serine proteases that are found in many different tissues and fluids in the body. The kallikrein protease family is comprised of potent vasodilators and hypotensives agents, thus they play important roles in inflammation and blood pressure. These enzymes normally reside in the body as inactive prekallikreins, which are activated by Hageman factor.\nConcepts: Kininogenin (Mediator of immune response)\tenterobacterial common antigen biosynthesis (Molecular Function)\t1F4 GARDNERELLA (Bifidobacteriaceae)\tCongenital hypogonadotropic hypogonadism (Congenital Disorders)\tMeningohydroencephalocele (Neural Tube Defects)", + "output": "Kininogenin (Mediator of immune response)" + }, + { + "input": "Definition: Mammal described as developed by Dr. Carl Hansen at the NIH, this strain was derived from a cross between NIH Swiss and C57BL/6N mice. The Black Swiss mouse has genotype Tyrp1B, (a) and is homozygous for the rd1 mutation of the Pde6b gene.\nConcepts: FARNESYLTRANSFERASE, CAAX BOX, ALPHA (Gene or Genome)\tRhamnogalacturonans (Pectins)\tLeiomyosarcoma - uterus (leiomyosarcoma)\tBlack Swiss Mouse (Mammal)\tAUMCIFO (Quantitative Concept)", + "output": "Black Swiss Mouse (Mammal)" + }, + { + "input": "Definition: something described as the nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo.\nConcepts: megagametophyte egg cell nucleus (megasporocyte nucleus)\tKnown History of Acute Rheumatic Fever or Rheumatic Heart Disease (Medical History)\tIVD Test Reagent/Kits, Serology, Virus, Saint Louis Encephalitis, IgM Antibody (IVD Test Reagent/Kits, Serology, Virus, Saint Louis Encephalitis, Antibody)\tCatfishes (Characiphysae)\tregulation of 18-methylnonadec-1-ene biosynthesis (Molecular Function)", + "output": "megagametophyte egg cell nucleus (megasporocyte nucleus)" + }, + { + "input": "Definition: AVLT-REY Functional Test Question described as auditory Verbal Learning Test - List A, Word 12.\nConcepts: Fatty Acid 23:1 (Organic Chemical)\tlateral line nerve glial cell development (glial cell development)\tcatalase-negative or weak group of campylobacteria (Bacterium)\tAVLT-REY - List A Word 12 (AVLT-REY Functional Test Question)\tpT2a Cancer of the Prostate (Prostate Cancer pT2 TNM Finding v6 and v7)", + "output": "AVLT-REY - List A Word 12 (AVLT-REY Functional Test Question)" + }, + { + "input": "Definition: Nose described as subdivision of surface of viscerocranial mucosa in the middle meatus. Examples: There are only two canonical instances, right and left agger nasi.\nConcepts: aryl-alcohol:NAD+ oxidoreductase activity (Molecular Function)\tCapsule, hard + tablet (Biomedical or Dental Material)\tCalcineurin Inhibitor - Induced Nephropathy (Disease or Syndrome)\tAgger nasi (Region of surface of viscerocranial mucosa)\tCuffs, Pneumatic Tourniquet, Double Bladder, Contoured, Reusable (Medical Device)", + "output": "Agger nasi (Region of surface of viscerocranial mucosa)" + }, + { + "input": "Definition: something described as using personal training assessment methods in a usual, 30-minute, out-of-office meeting to assess the health status of a new client to develop a personal training plan.\nConcepts: Krukenberg Carcinoma (Secondary malignant neoplasm of intra-abdominal organs)\tThe Overactive Bladder Questionnaire Short Form (Clinical or Research Assessment Questionnaire)\tnew30min xofc ptrn ntak (Remote location new client without ICD diagnosis)\tSum of Diameters (Quantitative Concept)\tpoorly differentiated carcinoma, salivary gland (squamous cell carcinoma of salivary gland)", + "output": "new30min xofc ptrn ntak (Remote location new client without ICD diagnosis)" + }, + { + "input": "Definition: something described as epilepsy triggered by an external stimulus or an internal mental process. Photosensitive epilepsy is the most common form of reflex epilepsy.\nConcepts: Adverse Event Classification (Classification)\tReflex epilepsy (Disease or Syndrome)\tKaposi's sarcoma of extrahepatic bile duct (Kaposi Sarcoma)\tNervous System Findings Domain (Intellectual Product)\tCommunication enhancement: hearing deficit (Otorhinolaryngologic service or procedure)", + "output": "Reflex epilepsy (Disease or Syndrome)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a condyloid synovial joint within the first digit of the hand articulating the metacarpal to the proximal phalanx.\nConcepts: D-lysine degradation (D-lysine metabolic process)\tregulation of innate immune response (regulation of response to external stimulus)\tSplenic vein (Structure of tributary of portal vein)\tMetacarpophalangeal Joint 1 (Body Part, Organ, or Organ Component)\tdiabetes; neonatal (ENDOCRINE FEATURES)", + "output": "Metacarpophalangeal Joint 1 (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Agenesis of corpus callosum described as a very rare congenital syndrome characterized by hypoplasia of the optic nerve, impaired vision, absence of the septum pellucidum and hypopituitarism.\nConcepts: Baths, Steam (Baths)\tCompleting my usual duties at work (Clinical or Research Assessment Question)\tdysplasia; septo-optic (Eye Abnormalities)\tregulation of xenobiotic detoxification by transmembrane export across the plasma membrane (regulation of transmembrane transport)\tdownregulation of sodium:hydrogen antiporter activity (regulation of sodium:proton antiporter activity)", + "output": "dysplasia; septo-optic (Eye Abnormalities)" + }, + { + "input": "Definition: General health described as a feeling of general discomfort or uneasiness, an out-of-sorts feeling.\nConcepts: Feels unwell (Disorders, General, Functional and NEC)\ttapasin binding (Molecular Function)\tPick-Niemann (Autosomal recessive hereditary disorder)\tupregulation of endosome to plasma membrane protein transport (positive regulation of intracellular protein transport)\tinfection; dialysis catheter (Disease or Syndrome)", + "output": "Feels unwell (Disorders, General, Functional and NEC)" + }, + { + "input": "Definition: examination of umbilical cord described as excessive granulation tissue at the base of the umbilicus after separation.\nConcepts: micromanipulation (Laboratory Procedure)\thypothalamus - not otherwise specified (Hypothalamic structure)\tUMBILICAL GRANULOMA (Granulomatous and deep cutaneous inflammatory conditions)\tPrevotellaceae Krieg 2012 (Bacteroidetes)\tIonising radiation steriliser (Sterilizing Units)", + "output": "UMBILICAL GRANULOMA (Granulomatous and deep cutaneous inflammatory conditions)" + }, + { + "input": "Definition: Skin, Human described as loose, wrinkled skin of hands and feet.\nConcepts: Status Date (Temporal Concept)\tolive (Flower Essences)\tExcessive skin wrinkling of palms and soles (Excessive wrinkling of palmar skin)\tClopamide [ingred see bdek.] (Thiazide Diuretics)\tcardiopulmonary resuscitation management (Therapeutic or Preventive Procedure)", + "output": "Excessive skin wrinkling of palms and soles (Excessive wrinkling of palmar skin)" + }, + { + "input": "Definition: Tumor Markers described as an antigenic epitope that is a 20 amino acid sequence from the extracellular portion of the transmembrane protein mucin-1 (MUC1). Overexpression of MUC1 induces the shedding of its extracellular domain into the bloodstream. Increased MUC1 in the blood may be a marker for breast cancer.\nConcepts: iAMP21 (Cell or Molecular Dysfunction)\tregulation of cell morphogenesis involved in differentiation (regulation of cell morphogenesis)\tCA27.29 (Immunologic Factor)\tpositive regulation of multi-organism process (regulation of multi-organism process)\tGrave Robbing (Individual Behavior)", + "output": "CA27.29 (Immunologic Factor)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as a very rare inborn error of metabolism disorder with a highly variable phenotype. Typical characteristics are neonatal to infancy-onset of seizures, psychomotor delay and abnormal muscle tone that may include hypo and/or hypertonia, resulting in generalised weakness, dystonic movements, and/or progressive respiratory distress, associated with severe lactic acidosis and elevated lactate, ketoglutarate and 2-oxoacids in urine. Additional manifestations may include dehydration, vomiting, signs of liver dysfunction, extrapyramidal signs, spastic tetraparesis, brisk deep tendon reflexes, speech impairment, swallowing difficulties and pulmonary hypertension. There is evidence the disease is caused by compound heterozygous mutation in the LIPT1 gene on chromosome 2q11.\nConcepts: Grade 2 Proctitis (Proctitis, CTCAE)\tTranslucent (Physical shape)\tLipoyl transferase 1 deficiency (Autosomal recessive hereditary disorder)\tCARBONIC ANHYDRASE INHIBITORS (Ophthalmic Agents)\tData Interface Units, Physiologic Monitor/Information System (Data Interface Units)", + "output": "Lipoyl transferase 1 deficiency (Autosomal recessive hereditary disorder)" + }, + { + "input": "Definition: something described as a groove on the surface of each frontal lobe of the brain that separates the superior frontal gyrus from the middle frontal gyrus.\nConcepts: sfrs (frontal lobe)\tPathway, Autonomic (Autonomic nervous system)\tNCCN-FACT FHNSI-22 Version 2 (Clinical or Research Assessment Questionnaire)\tImpaired Health Maintenance (Finding)\t13b (Body Location or Region)", + "output": "sfrs (frontal lobe)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a member of the IL-8 superfamily of cytokines and released from platelets and activated T-cells, RANTES is a selective chemoattractant for eosinophils, monocytes, and T-lymphocytes. RANTES is one of the ligands for chemokine receptor CCR5. RANTES expression in peripheral lymphocytes increases exponentially following mitogenic or antigenic stimulation. RANTES is one of the major HIV-suppressive factors produced by CD8-positive T-cells.\nConcepts: Aplasia/Hypoplasia of the mandible (Aplasia/Hypoplasia involving bones of the skull)\tRegulated on Activation, Normal T Expressed and Secreted (Recombinant Beta Chemokine)\tMUC1-targeted Peptide GO-203-2C (Amino Acid, Peptide, or Protein)\tPODCI124 (Intellectual Product)\taminolevulinic acid (Medicinal product categorized by structure)", + "output": "Regulated on Activation, Normal T Expressed and Secreted (Recombinant Beta Chemokine)" + }, + { + "input": "Definition: Cardiovascular system alteration described as state of increased caliber of the blood vessels.\nConcepts: response to starvation (biological adaptation to stress)\tPeripheral vascular dilatation (positive regulation of blood vessel diameter)\tPatient Care Continuity (Primary Health Care)\tInvertebrate Photoreceptor Cell (Photoreceptors)\tFAC10058 (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "Peripheral vascular dilatation (positive regulation of blood vessel diameter)" + }, + { + "input": "Definition: Quantitative Concept described as picomoles per liter (concentration), divided by milligrams per day (daily dose).\nConcepts: Picomole per Liter per Milligram per Day (Quantitative Concept)\tGenital Edema (Finding)\tDyskeratosis Congenita Gene Deletion/Duplication Panel Reagents (IVD Panels, Human Genetics, Bone Marrow Syndrome, Dyskeratosis Congenita)\tNodular subcortical heterotopia in peritrigonal regions (Finding)\tRadiographic Image Not Correlated with Tumor Pathology Finding (Status of correlation between radiographic image and pathologic finding)", + "output": "Picomole per Liter per Milligram per Day (Quantitative Concept)" + }, + { + "input": "Definition: Cytoskeletal Gene described as this gene plays a role in muscle filament movement.\nConcepts: CALASPARGASE PEGOL-MKNL (Antineoplastic Agents)\tCATHETER,INTRAVASCULAR,THERAPEUTIC,SHORT-TERM LESS THAN 30 DAYS (Medical Device)\tQuickDASH Outcome Measure (Intellectual Product)\tSPAG11 (SPAG11B gene)\ttroponin T type 2 (Gene Mutation)", + "output": "troponin T type 2 (Gene Mutation)" + }, + { + "input": "Definition: something described as uterine endometrium biopsy curettes designed to remove tissue from the internal lining of the cervical canal. These curettes are typically single-use synthetic (e.g., nylon), handheld, manual instruments that can remove superficial cells with minimal damage to the tissue. Uterine cervix biopsy curettes are used to obtain histologic tissue samples from the endocervical canal for early detection of endocervical carcinoma (e.g., cervical cancer screening tests).\nConcepts: Degradation (Material Integrity Problem)\tCurettes, Biopsy, Uterine, Endometrium, Cervical Canal (Curettes, Biopsy, Uterine, Endometrium)\tSpring-Loaded Orthopedic Shoes (Medical Device)\tEndonexin II (Biologically Active Substance)\tMIRN106B (MIR106B gene)", + "output": "Curettes, Biopsy, Uterine, Endometrium, Cervical Canal (Curettes, Biopsy, Uterine, Endometrium)" + }, + { + "input": "Definition: Bottle, device described as a bottle that is used by the pharmacist to dispense the prescribed medication. It includes preparations for which a dropper accompanies the bottle.\nConcepts: olfactory areas (Body Location or Region)\tGastric foveolar (Neoplastic Process)\tD-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, Sodium Salt (ampicillins)\tfibroblast cell migration (Cell Function)\tBottle, Dispensing (Bottle, device)", + "output": "Bottle, Dispensing (Bottle, device)" + }, + { + "input": "Definition: something described as a relative measurement (ratio or percentage) of the malignant lymphocytes to all leukocytes in a biological specimen.\nConcepts: Study Date (Temporal Concept)\tLymphoma Cells/Leukocytes (Blood Cell Count Ratio Measurement)\tRecurrent Primary Peritoneal Endometrioid Adenocarcinoma (Recurrent Primary Peritoneal Carcinoma)\tTriaminic Syrup (Clinical Drug)\tBET inhibitor RO6870810 (BET Inhibitor)", + "output": "Lymphoma Cells/Leukocytes (Blood Cell Count Ratio Measurement)" + }, + { + "input": "Definition: DNA strand elongation involved in cell cycle DNA replication described as any DNA strand elongation that is involved in nuclear cell cycle DNA replication.\nConcepts: inhibition of gluconeogenesis (Physiologic Function)\tActin Capping Protein (Amino Acid, Peptide, or Protein)\tNon-Target Non-Enhancing Lesion Response (Finding)\tDNA strand elongation involved in DNA replication involved in S phase (Genetic Function)\tPaced Ventricular Rhythm (Finding)", + "output": "DNA strand elongation involved in DNA replication involved in S phase (Genetic Function)" + }, + { + "input": "Definition: Neurological surgical device described as a neurosurgical suture needle is a needle used in suturing during neurosurgical procedures or in the repair of nervous tissue.\nConcepts: Maxilla residual ridge morphology (Maxilla residual ridge finding)\tB-1 B lymphocyte homeostasis (Cell Function)\tPrimary Mediastinal Precursor T-Lymphoblastic Lymphoma (Precursor T-cell lymphoblastic lymphoma)\tNeurosurgical suturing needle (Neurological surgical device)\tReduced factor XIII, subunit B (Reduced factor XIII activity)", + "output": "Neurosurgical suturing needle (Neurological surgical device)" + }, + { + "input": "Definition: Age described as the age at which the first hospitalization event occurred.\nConcepts: RDQ01-Trouble Putting on Socks/Stockings (Intellectual Product)\tneuroepithelial tumor (Neoplasms)\tAGEHOSP1 (Age)\tMattresses, Alternating-Pressure (Mattress Systems)\tPhysiatry (Medical Specialities)", + "output": "AGEHOSP1 (Age)" + }, + { + "input": "Definition: Clinical actions A - G described as removal of the contents of a body cavity or container\nConcepts: Term Birth (Normal pregnancy, labour and delivery)\tevacuations (Clinical actions A - G)\tWinkia neuii (Funke et al. 1994) Nouioui et al. 2018 (Aerotolerant Actinomyces species)\tMetastatic carcinoid tumor (Metastatic Well Differentiated Neuroendocrine Neoplasm)\tEsophageal lymph node (Lymph node group)", + "output": "evacuations (Clinical actions A - G)" + }, + { + "input": "Definition: Pelvic Bones described as the largest of three bones that make up each half of the pelvic girdle.\nConcepts: 28 LUNGS (Pulmonary structure including vessels and lymphoid tissue)\tNegative Cell Enrichment (Laboratory Procedure)\tregulation of stem cell renewal (Cell Function)\tBone structure of ilium (Hip Bone)\tintegral to MOM (integral component of cell outer membrane)", + "output": "Bone structure of ilium (Hip Bone)" + }, + { + "input": "Definition: something described as intracorporeal lithotripters that use plasma-induced shock waves to fracture stones. A generator-powered probe fires energy pulses at the stone, while the probe is irrigated with a saline solution. The collapse of the resulting plasma bubble causes a hydraulic shock that fragments the stone into several pieces that can then be removed using a grasper or stone basket.\nConcepts: MUSCTS (Intellectual Product)\tADP-dependent medium-chain hydrolase activity (Molecular Function)\tKlebsiella Trevisan 1885 (Approved Lists 1980) emend. Carter et al. 1999 (Bacterium)\tLithotripters, Intracorporeal, Electrohydraulic (Medical Device)\tpositive regulation of protein localization to meiotic spindle pole body (Cell Function)", + "output": "Lithotripters, Intracorporeal, Electrohydraulic (Medical Device)" + }, + { + "input": "Definition: something described as a unit of measure of quantity of substance per unit mass, expressed in terms of international units per milligram.\nConcepts: Comprehensive Ectodermal Dysplasia Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Multisystem Disorder, Ectodermal Dysplasia)\tadenosylcobalamin-dependent D-lysine 5,6-aminomutase activity (Molecular Function)\tMethylprednisolone-21-acetate (Hormonal Agents, Stimulant/ Replacement/ Modifying)\tchemotherapy intrathecal (Therapeutic or Preventive Procedure)\tInternational Unit/Milligram (IU per unit mass)", + "output": "International Unit/Milligram (IU per unit mass)" + }, + { + "input": "Definition: Neoplastic Process described as cancer that is growing, spreading, or getting worse.\nConcepts: StudySiteProtocolVersionRelationship.effectiveDateRange (Effective Date Range)\tYEATS1 (Gene or Genome)\talpha (1,3) galactosyltransferase tumor vaccine (Allogeneic Tumor Cell Vaccine)\tProgressive Neoplastic Disease (Progressive Disease)\tPerception, Temporal (Thesaurus of Psychological Index Terms)", + "output": "Progressive Neoplastic Disease (Progressive Disease)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Orientation task for knowing the current year.\nConcepts: Microfibril Collagen Hemostat (Amino Acid, Peptide, or Protein)\tFAC018-Bothered by Lumps or Swelling (FACT-LYM Version 4 Questionnaire Question)\tOrientation: Year (Intellectual Product)\tCHEM WATER POLLUTANTS (Hazardous or Poisonous Substance)\tPRSCAT (Subcategory)", + "output": "Orientation: Year (Intellectual Product)" + }, + { + "input": "Definition: Adrenal Gland Diseases described as an autoimmune diseases affecting multiple endocrine organs\nConcepts: syndrome; autoimmune polyglandular (Autoimmune endocrine disease)\tFunctional Gastrointestinal Disorders (Disease or Syndrome)\tCLOSTRIDIUM SEPTICUM (Clostridium species q-z)\tP-Phi-B synthase activity (oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor)\tJoint fluid (Synovial joint structure)", + "output": "syndrome; autoimmune polyglandular (Autoimmune endocrine disease)" + }, + { + "input": "Definition: Laboratory microscope described as microscopes designed to magnify an image using an electron beam instead of light, which allows greater magnification (500,000x is typical) and resolution than a light microscope. The images are usually observed on a fluorescent screen or through photographs. There are two basic types of electron microscopes: the transmission electron microscope (TEM), which basically operates like a light microscope but uses an electron beam, and scanning electron microscopes (SEM), which provide a three-dimensional image of the surface of the examined object; some electron microscopes combine both techniques. TEMs intended for clinical use permit highly detailed visualization of tissue, individual cells, and cell structures; SEMs are intended mainly for research and, less frequently, for clinical applications.\nConcepts: EARLY INTRAUTERINE DEATH (Cessation of life)\ttetanus toxoid vaccine, inactivated (VaccineType)\tUndifferentiated epithelioid sarcoma (undifferentiated sarcoma of soft tissue)\tDepleted blood volume (Metabolic Diseases)\tElectron Microscopes (Microscopes)", + "output": "Electron Microscopes (Microscopes)" + }, + { + "input": "Definition: something described as stage I includes: (T1, N0, M0). T1: Tumor confined to vagina. N0: No regional lymph node metastasis. M0: No distant metastasis.\nConcepts: INTERFERON, GAMMA (Signaling Pathway Gene)\tFIGO Stage I Vagina Carcinoma (Neoplastic Process)\tPhysical Removal Decontaminants (Decontaminants)\tPQL18-Get Hurt Accidentally (Intellectual Product)\thyperlipoproteinaemias (Abnormality of lipoprotein cholesterol concentration)", + "output": "FIGO Stage I Vagina Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: GNAS Protein Variant described as a change in the amino acid residue at position 201 in the guanine nucleotide-binding protein G(s) subunit alpha isoforms short protein where arginine has been replaced by serine.\nConcepts: nucleoside diphosphate biosynthetic process (Molecular Function)\tGuanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short Arg201Ser (GNAS Protein Variant)\tallodepleted haploidentical T cells expressing inducible Caspase 9 (Genetically-engineered Immune Cell)\toral dosage form (Type of drug preparation)\tPremature calcification of mitral annulus (Calcification of mitral valve)", + "output": "Guanine Nucleotide-Binding Protein G(s) Subunit Alpha Isoforms Short Arg201Ser (GNAS Protein Variant)" + }, + { + "input": "Definition: regulation of cellular metabolic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.\nConcepts: OAB-q Short Form - Affected Your Relationships with Family and Friends (OAB-q Short Form Questionnaire Question)\tUndersurface of the Temporal Lobe (Body Location or Region)\tDocument Version Relationship (Qualitative Concept)\tregulation of pteridine metabolism (Cell Function)\tcornified envelope formation (Cell Function)", + "output": "regulation of pteridine metabolism (Cell Function)" + }, + { + "input": "Definition: Fallopian Tube Endometrioid Tumor described as a carcinosarcoma that arises from the fallopian tube. It usually affects postmenopausal women and presents with abdominal pain, abdominal distension or genital bleeding. The prognosis is usually poor.\nConcepts: CR Tab (Oral Dosage Form)\tFallopian Tube Malignant Mixed Mesodermal (M\u00fcllerian) Tumor (Malignant neoplasm of fallopian tube)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Neurologic, Antiganglioside Antibody, GM1 (Medical Device)\taleurone grain membrane (Cytoplasmic vesicle membrane)\tnegative regulation of Wnt receptor signaling pathway through beta-catenin involved in neural plate anterior/posterior pattern formation (negative regulation of canonical Wnt signaling pathway)", + "output": "Fallopian Tube Malignant Mixed Mesodermal (M\u00fcllerian) Tumor (Malignant neoplasm of fallopian tube)" + }, + { + "input": "Definition: Finding described as a finding that indicates the amount of total bilirubin in a sample.\nConcepts: Total Bilirubin Level Finding (Finding)\tcuvettes (Medical Device)\tNCI CTEP Simple Disease Classification Head and Neck Neoplasm, Miscellaneous Sub-Category Terminology (NCI CTEP SDC Head and Neck Neoplasm Category Terminology)\tcardiac computerized tomographic angiography (Diagnostic Procedure)\tAmpulla of Vater Cancer Pathologic Distant Metastasis TNM Finding v7 (Ampulla of Vater Cancer Pathologic TNM Finding v7)", + "output": "Total Bilirubin Level Finding (Finding)" + }, + { + "input": "Definition: something described as a system of physical units in which the fundamental quantities are length, time, mass, electric current, temperature, luminous intensity, and amount of substance, and the corresponding units are the meter, second, kilogram, ampere, kelvin, candela, and mole. The system has been given official status and recommended for universal use by the General Conference on Weights and Measures.\nConcepts: Follicular cholangitis and pancreatitis (Pancreatitis)\tEducation about use of covering device (Educational Activity)\tSI (Intellectual Product)\tLOCF (Quantitative Concept)\tPUL0205 (PUL 2.0 Functional Test Question)", + "output": "SI (Intellectual Product)" + }, + { + "input": "Definition: area 19 of Vogts described as one of two parts of area 19 of Vogts based on cytoarchitecture and myeloarchitecture in the guenon. The authors regarded it as topologically homologous to area 19 of Mauss , but not to area 19 of Brodmann (guenon). The other part is area 19b of Vogts ( Vogts-1919 ).\nConcepts: crisis management (Therapeutic or Preventive Procedure)\tearly stripe melanocyte differentiation (Cell Function)\tarea 19a of Vogts (Body Part, Organ, or Organ Component)\tRET Inhibitor LOXO-292 (Pharmacologic Substance)\tIVD Panels, Human Genetics, Rasopathies, Multiple Lentigines Syndrome (Medical Device)", + "output": "area 19a of Vogts (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a response indicating that something is extremely interfering.\nConcepts: Microenterprises (Quantitative Concept)\tlinoleic acid binding (long-chain fatty acid binding)\tmL/24.h (Quantitative Concept)\tMental Health @ None @ Hypnosis @ None @ None @ None @ None (Psychotherapy)\tExtremely (Finding)", + "output": "Extremely (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as heparin-binding proteins which exhibit inflammatory and immunoregulatory activities; they are produced by a variety of cell types including neutrophils, fibroblasts, and epithelial cells; they most likely play a significant role in respiratory tract defenses.\nConcepts: mip (Immunologic Factor)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, HSD17B4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tgamete intrafallopian transfer (Procedures on the fallopian tube)\tContracture of the distal interphalangeal joint of the second toe (Flexion contracture of the 2nd toe)\tpeptide transmembrane transporter activity (Molecular Function)", + "output": "mip (Immunologic Factor)" + }, + { + "input": "Definition: something described as a proprietary separation column manufactured by New Objective.\nConcepts: Hydrocarbons, Fluorinated (Organic Chemical)\tDoes a hearing problem cause you to avoid groups of people (Intellectual Product)\t3-phosphoglyceric acid kinase activity (Molecular Function)\tNew Objective Column (Separation Column)\ttri-O-acetyluridine (Genetic or Enzyme or Protein Disorder: Replacement, Modifiers, Treatment)", + "output": "New Objective Column (Separation Column)" + }, + { + "input": "Definition: Penile hypospadias described as a severe form of hypospadias in which the urethral opening is located at the junction of the penis and scrotum.\nConcepts: Bromhexine metabolite vIII (mucolytic agents)\tHypospadias, penoscrotal (Posterior hypospadias)\t10: 95507668-95547906 (Chromosome 10 Physical Location)\tED2-Use Toilet Independently (Expanded DRS-PI Survivor Version Questionnaire Question)\tmiRNA221 (MIR221 gene)", + "output": "Hypospadias, penoscrotal (Posterior hypospadias)" + }, + { + "input": "Definition: EYES AND EYE APPENDAGES described as the part of the conjunctiva, a thin transparent mucous membrane, that is loosely attached the orbital septum and covers the anterior surface of the sclera.\nConcepts: Dicarboxylic Acid (Organic Chemical)\tfruit ripening, climacteric (ripening)\tInternational Cancer Research Portfolio Database (Databases)\tBulbar conjunctiva (EYES AND EYE APPENDAGES)\tMENTAL RETARDATION, X-LINKED 32 (Disease or Syndrome)", + "output": "Bulbar conjunctiva (EYES AND EYE APPENDAGES)" + }, + { + "input": "Definition: Activities described as performance of physical exertion for improvement of health or correction of physical deformity.\nConcepts: Zafirlukast (Leukotriene receptor antagonists for obstructive airway diseases)\tStage IVC Lip and Oral Cavity Cancer AJCC v6 (Stage IV Lip and Oral Cavity Cancer AJCC v6 and v7)\tThrombocyte count abnormal (Abnormal blood cell count)\tSpeech Amplifiers (Medical Device)\tPhysical Activity (Activities)", + "output": "Physical Activity (Activities)" + }, + { + "input": "Definition: Adrenal Cortex Hormones described as a synthetic steroid with anabolic and androgenic properties.\nConcepts: SDTMIG Version 3.1.1 (Study Data Tabulation Model Implementation Guide Version)\tAcid, Piperamic (Organic Chemical)\tMethandriol-containing product (Androgens, Synthetic)\tTGF-beta receptor complex assembly (Molecular Function)\tAnti-HER2 Antibody Expressing Pluripotent Killer T-Cells (Antineoplastic Immune Cell)", + "output": "Methandriol-containing product (Androgens, Synthetic)" + }, + { + "input": "Definition: Hereditary nephritis described as hereditary disorder characterized by progressive sensorineural hearing loss, progressive pyelonephritis or glomerulonephritis, and, occasionally, ocular defects; transmitted as an autosomal dominant or X-linked trait.\nConcepts: Syndrome, Hematuria-Nephropathy-Deafness (Sensorineural Hearing Loss)\tAROM (Cytochrome P450 Family 19)\tSTAIN, PONCEAU (Organic Chemical)\t1-carbamoylmethyl-3-carbamoyl-1,4-dihydropyridine/5-(aziridin-1-yl)-2,4-dinitrobenzamide (Antineoplastic Agents)\tHigh Resolution Anoscopy with Biopsy (Diagnostic Endoscopic Procedure)", + "output": "Syndrome, Hematuria-Nephropathy-Deafness (Sensorineural Hearing Loss)" + }, + { + "input": "Definition: Head described as a head tremor of moderate speed (3 to 4 Hz) in the anterior-posterior direction.\nConcepts: mastitis (Inflammation of specific body organs)\tCarnitine palmitoyl transferase 2 deficiency (Disorder of fatty acid metabolism)\tSOLUTION, HELLY (Indicator, Reagent, or Diagnostic Aid)\tHead titubation (Head tremor)\tOssifying fibroma (Degenerative disorder of bone)", + "output": "Head titubation (Head tremor)" + }, + { + "input": "Definition: Temporal Concept described as the 24 hour period occurring just before the present time.\nConcepts: Tractus cerebello-thalamo-cerebralis (Body Part, Organ, or Organ Component)\tspondyloepiphyseal dysplasias (Collagen-vascular disease)\tDRS01-Employability (Intellectual Product)\tBermuda Grass Pollen IgE Measurement (Immunoglobulin measurement)\tLast 24 Hours (Period)", + "output": "Last 24 Hours (Period)" + }, + { + "input": "Definition: Descriptors described as a state of connectedness between people, objects, or events; to be associated or connected with something.\nConcepts: enterobactin transport (Cell Function)\tsmall molecule metabolic process (Organism Function)\tASEX02-Sexually Aroused (Intellectual Product)\trelationship (HL7 Vocabulary Version 2.5)\ttransmembrane receptor protein serine/threonine kinase signalling pathway (enzyme linked receptor protein signaling pathway)", + "output": "relationship (HL7 Vocabulary Version 2.5)" + }, + { + "input": "Definition: Metallopeptidase Gene described as this gene plays a role in cell migration, inflammation and the regulation of extracellular matrix remodeling.\nConcepts: MIRN125A (Gene or Genome)\tCOLLAGENASE, INTERSTITIAL (Gene or Genome)\thydroxycineol metabolic process (Molecular Function)\tNeuroblastoma Children's Cancer Society (Health Care Related Organization)\tTele-Imaging Systems (Medical Device)", + "output": "COLLAGENASE, INTERSTITIAL (Gene or Genome)" + }, + { + "input": "Definition: something described as trauma Symptom Checklist for Young Children - Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Spacing out.\nConcepts: Allyl cinerin (Pyrethroids)\tTSCYC1-Spacing Out (TSCYC Questionnaire Question)\ttRNA wobble guanine modification (Genetic Function)\tsyndecan (Proteoglycan)\tTitanium Metallicum (Element, Ion, or Isotope)", + "output": "TSCYC1-Spacing Out (TSCYC Questionnaire Question)" + }, + { + "input": "Definition: something described as a question about how satisfied or dissatisfied an individual is or was with how naturally their reconstructed breasts sits and hangs.\nConcepts: Satisfaction with How Naturally Your Reconstructed Breasts Sits and Hangs (Clinical or Research Assessment Question)\tMale Erectile Disorder (Autonomic nervous system disorders)\tComprehensive Health Care (patient care)\tCusp Tethering Indicator (Indicator)\tAplasia of the fifth metatarsal bone (Foot)", + "output": "Satisfaction with How Naturally Your Reconstructed Breasts Sits and Hangs (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the determination of the amount of CCL8, chemokine (C-C motif) ligand 8, present in a sample.\nConcepts: TPIV-200 (Vaccines, Peptide)\tBethlem sign (Finding)\tCCL8 (Chemokine Measurement)\tPODCI Adolescent Parent-Reported Version - Outdoor Limited by: Instructions (Intellectual Product)\tIVD Panels, Human Genetics, Metabolic Disorder, Lysosomal Storage Disease, Lipidosis (Medical Device)", + "output": "CCL8 (Chemokine Measurement)" + }, + { + "input": "Definition: cyclin-dependent protein kinase holoenzyme complex location described as cyclin-dependent protein kinase (CDK) complex found in the cytoplasm.\nConcepts: Plexiform Neurofibroma (Benign Neoplasm)\tAutosomal recessive cerebellar ataxia with saccadic intrusion syndrome (Abnormal saccadic eye movement)\tCatheters, Spinal, Intervertebral Disc, Radiofrequency Ablation, Lumbar (Catheters, Spinal, Intervertebral Disc, Radiofrequency Ablation)\tcytoplasmic cyclin-dependent protein kinase holoenzyme complex location (cyclin-dependent protein kinase holoenzyme complex location)\tCXCL12-Abundant Reticular Cell (Reticulum cell)", + "output": "cytoplasmic cyclin-dependent protein kinase holoenzyme complex location (cyclin-dependent protein kinase holoenzyme complex location)" + }, + { + "input": "Definition: Disorder of eye described as an abnormality resulting from a lesion of the sympathetic nervous system characterized by a combination of unilateral ptosis, miosis, and often ipsilateral hypohidrosis and conjunctival injection.\nConcepts: Oculosympathetic palsy (Blepharoptosis)\tobesity-mental retardation-delayed puberty-macroorchidism-acanthosis nigricans-hyperinsulinemia syndrome (Disease or Syndrome)\tNursing & Custodial Care Facilities; Skilled Nursing Facility, \"Nursing Care, Pediatric\" (Manufactured Object)\tPeroxysoma (Membranous cytoplasmic organelle)\tpseudophakia (Finding)", + "output": "Oculosympathetic palsy (Blepharoptosis)" + }, + { + "input": "Definition: negative regulation of leukocyte apoptotic process described as any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte death by apoptotic process.\nConcepts: OLANZapine (dibenzodiazepines)\tSebaceous Adenocarcinoma (Primary malignant neoplasm of skin)\tLymphocyte Destruction Inhibition (negative regulation of leukocyte apoptotic process)\tTriweekly (Intervals of weeks and months)\tSocial Insurance (Public Assistance)", + "output": "Lymphocyte Destruction Inhibition (negative regulation of leukocyte apoptotic process)" + }, + { + "input": "Definition: Finding described as a score developed by Allred et al. (1998) and assigned based on the average staining intensity of cells for a particular protein (Allred DC, Harvey JM, Berardo M, Clark GM. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod Pathol. 1998 Feb;11(2):155-68).\nConcepts: ALLRED STAINING INTENSITY SCORE (Other Finding)\tthoracic meningomyelocele (Thoracic myelocele)\tFIQR - Anxiety (Intellectual Product)\tGamma-Aminobutyric Acid Receptor Subunit Alpha-3 (Amino Acid, Peptide, or Protein)\tpregenual area (Body Location or Region)", + "output": "ALLRED STAINING INTENSITY SCORE (Other Finding)" + }, + { + "input": "Definition: something described as a measurement of the type II secretory phospholipase A2 in a biological specimen.\nConcepts: 3.3 (Study Data Tabulation Model Implementation Guide Version)\tNon-synonymous RAF Family Gene Mutation (RAF Family Gene Mutation)\tFAC023-I Get Support From My Friends (FACT-P Version 4 Questionnaire Question)\tVLERS (Intellectual Product)\tType II Secretory Phospholipase A2 (Laboratory Procedure)", + "output": "Type II Secretory Phospholipase A2 (Laboratory Procedure)" + }, + { + "input": "Definition: Fetal finding described as the first part of the fetus that is visible at the cervical opening during delivery.\nConcepts: hypnotics zolpidem (Pharmacologic Substance)\tFoetal presentation, NOS (Finding)\tTelencephalon medium (Body Part, Organ, or Organ Component)\tUSDA (Professional Organization or Group)\t9,12-epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)- (Antineoplastic Enzyme Inhibitor)", + "output": "Foetal presentation, NOS (Finding)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Heavy Chain described as immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically serum, but also urine) to determine alpha heavy chain fragments of monoclonal immunoglobulins (paraproteins). Alpha heavy chain diseases are associated with lymphoid infiltration, typically causing severe malabsorption in the intestines.\nConcepts: IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Heavy Chain, Alpha (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Heavy Chain)\tCriminal Justice (Legal Issues)\tantigen presentation, peptide antigen (Antigen Presentation)\tIVD Test Reagent/Kits, Microbiology, Buffer, Fungi/Yeast Test (Medical Device)\tParent Report (Intellectual Product)", + "output": "IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Heavy Chain, Alpha (IVD Test Reagent/Kits, Immunoassay, Tumor Marker, Protein, Monoclonal Ig, Heavy Chain)" + }, + { + "input": "Definition: something described as a rare genetic intellectual disability syndrome with characteristics of macrocephaly, hypotonia, dysmorphic facial features (wide forehead, ptosis, downslanting palpebral fissures, enlarged and calcified external ears, large jaw), sparse body hair and tall stature. Hearing loss, insulin-resistant diabetes, and progressive distal muscle wasting (leading to joint contractures) have also been reported in adulthood. Rare manifestations include hypothyroidism, cerebral calcification, ataxia and peripheral neuropathy. There is evidence this disease is caused by heterozygous mutation in the ZBTB20 gene on chromosome 3q13.\nConcepts: Bioactive substance (Substance)\tregulation of stationary phase (Cell Cycle Control)\tIntraretinal exudate (Retinal exudates)\tChemical Synapse Component (Cell Component)\tPRIMS (Disease or Syndrome)", + "output": "PRIMS (Disease or Syndrome)" + }, + { + "input": "Definition: something described as x-linked agammaglobulinemia. An immunodeficiency state characterized (usually) by profoundly low concentrations of serum immunoglobulins of all classes, although occasionally significant amounts of one or more isotypes can be found. The fundamental defect in XLA affects early lineage B cells.\nConcepts: Bruton's agammaglobulinemia (Congenital Immunodeficiency Diseases)\tRb (Rubidium and rubidium compound)\tGenus Acinetobacter (Non-fermentative Gram-negative bacillus)\tmin*mg/mL/m2 (Measurement Unit Description)\tN-glycolylneuraminic acid (Neu5Gc) cytidylyltransferase activity (cytidylyltransferase activity)", + "output": "Bruton's agammaglobulinemia (Congenital Immunodeficiency Diseases)" + }, + { + "input": "Definition: mental health counseling described as using family counseling techniques to assist a family member(s) in coping with their societal and/or environmental stressors. Service is billed in 15-minute increments.\nConcepts: Pseudostratified Columnar Ciliated Epithelium (Pseudostratified columnar epithelium)\tSocietal and/or environmental coping assistance family each 15 minutes (mental health counseling)\tIncomplete; narrow column air/contrast in laryngeal vestibule (Impairment of Laryngeal Vestibular Closure, Height of Swallow)\tLocation of Chest Pain (Body Location or Region)\tanterior basal cistern (Body Space or Junction)", + "output": "Societal and/or environmental coping assistance family each 15 minutes (mental health counseling)" + }, + { + "input": "Definition: something described as represents a fiber pathway connecting the thalamus to the parietal lobe of the cerebral cortex. It is not readily distinguished in myelin-stained histological cross-sections ( Carpenter-1983 ).\nConcepts: Set of thalamoparietal fibers (Set of neuraxis fibers)\tDistress over Emotional Problem with Nervousness (Findings-Based Question)\tcalcium carbonate (Allergen class)\tIVD Test Reagent/Kits, Immunoassay, Tumor Marker, Hormone Metabolite (Medical Device)\tPUL02-Flexion Above Shoulder Height 500g (PUL 2.0 Functional Test Question)", + "output": "Set of thalamoparietal fibers (Set of neuraxis fibers)" + }, + { + "input": "Definition: Finding described as a disorder characterized by an individual seeing spots before their eyes. The spots are shadows of opaque cell fragments in the vitreous humor or lens.\nConcepts: CHSF2-Occupation of Paid Work (CHART-SF Paper Version Questionnaire Question)\tdehydroabietadienol hydroxylase activity (Molecular Function)\tHaemoglobin uria (Red blood cell destruction finding)\tFloaters, CTCAE (Finding)\tSuperiors, Gyrus Temporalis (Cerebral dorsum structure)", + "output": "Floaters, CTCAE (Finding)" + }, + { + "input": "Definition: something described as books used for sex education and procedural instruction.\nConcepts: GP40 (Gene or Genome)\tProduct containing phenylalanine (Amino Acids, Cyclic)\thuman stomach cancer, transforming factor from FGF-related oncogene (Fibroblast Growth Factor Gene Family)\tSex Manuals (Intellectual Product)\tneurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration (Cell Function)", + "output": "Sex Manuals (Intellectual Product)" + }, + { + "input": "Definition: something described as a microtubule structure that forms during CELL DIVISION. It consists of two SPINDLE POLES, and sets of MICROTUBULES that may include the astral microtubules, the polar microtubules, and the kinetochore microtubules.\nConcepts: rnax perform ambulation therapy (Client satisfaction: physical care)\tInflammatory Liposarcoma (Liposarcoma, well differentiated)\tSpindle (Cytoskeleton)\tElectrical Fire Smoke Exposure (Fire Smoke Exposure)\tDCS1 decapping scavenger complex (phosphatase complex)", + "output": "Spindle (Cytoskeleton)" + }, + { + "input": "Definition: regulation of rRNA processing described as any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing.\nConcepts: negative regulation of rRNA processing (Genetic Function)\tPJRT - Permanent junctional reciprocating tachycardia (Atrioventricular junctional rhythm)\toxygenation (Metabolism)\tED1-Understand/Follow Directions (Intellectual Product)\tForebrain (nervous system divisions)", + "output": "negative regulation of rRNA processing (Genetic Function)" + }, + { + "input": "Definition: Effective Date Range described as the date and time span for when the product relationship is active.\nConcepts: Z-360 (Pharmacologic Substance)\tProductRelationship.effectiveDateRange (Temporal Concept)\tFull Body Weight Lifting Machines (Manufactured Object)\tcalcium-dependent protein serine/threonine phosphatase regulator activity (Molecular Function)\tNaming Objects and Fingers: 1 (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "ProductRelationship.effectiveDateRange (Temporal Concept)" + }, + { + "input": "Definition: Hereditary degenerative disease of central nervous system described as inherited or familial Creutzfeldt-Jakob disease (fCJD) is a very rare form of genetic prion disease characterized by typical CJD features (rapidly progressive dementia, personality/behavioral changes, psychiatric disorders, myoclonus, and ataxia) with a genetic cause and sometimes a family history of dementia.\nConcepts: Pectus excavatum inferiorly (Pectus excavatum)\tNeurosciences Research (Research Activity)\tFamilial Creutzfeldt-Jakob (Hereditary disorder of nervous system)\tmacrophage colony-stimulating factor receptor binding (Molecular Function)\ttendon sheath development (connective tissue development)", + "output": "Familial Creutzfeldt-Jakob (Hereditary disorder of nervous system)" + }, + { + "input": "Definition: regulation of glucosylceramidase activity described as any process that activates or increases the frequency, rate or extent of glucosylceramidase activity.\nConcepts: up regulation of glucocerebrosidase activity (positive regulation of hydrolase activity)\tCurly hair-acral keratoderma-caries syndrome (Hereditary disorder of the integument)\tAbortion induced illegally (Abortion, Criminal)\tBONERESP (Finding)\tPerformedMedicalConditionResult (Finding)", + "output": "up regulation of glucocerebrosidase activity (positive regulation of hydrolase activity)" + }, + { + "input": "Definition: something described as a nuclear imaging procedure which is performed to identify hyperparathyroidism. Sestamibi is a nuclear radiopharmaceutical which is bound to the radioactive isotope Tc99m. Tc99m-Sestamibi is taken up by both the thyroid gland and the parathyroid gland, and is also used in Nuclear Myocardial Perfusion Imaging.\nConcepts: sestamibi scan (Diagnostic Procedure)\tregulation of protein catabolic process at presynapse, modulating synaptic transmission (Cell Function)\tPeritoneal and Retroperitoneal Hemorrhage (Disease or Syndrome)\tLENS, CONTACT, FOR COLOR VISION DEFICIENCY (Medical Device)\tLipoma of the Internal Auditory Canal (Neoplasm of the inner ear)", + "output": "sestamibi scan (Diagnostic Procedure)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as irradiation of one half or both halves of the body in the treatment of disseminated cancer or widespread metastases. It is used to treat diffuse metastases in one session as opposed to multiple fields over an extended period. The more frequent treatment modalities are upper hemibody irradiation (UHBI) or lower hemibody irradiation (LHBI). Less common is mid-body irradiation (MBI). In the treatment of both halves of the body sequentially, hemibody irradiation permits radiotherapy of the whole body with larger doses of radiation than could be accomplished with WHOLE-BODY IRRADIATION. It is sometimes called \"systemic\" hemibody irradiation with reference to its use in widespread cancer or metastases.\nConcepts: Hemi body irradiation (irradiation site)\tChromatin extended (Cell Component)\tThis decision is easy for me to make (Clinical or Research Assessment Question)\tCSS0719A (C-SSRS Children's Baseline/Screening Questionnaire Question)\tArg binding (Molecular Function)", + "output": "Hemi body irradiation (irradiation site)" + }, + { + "input": "Definition: Qualitative Concept described as specifies the link between an adverse event causal assessment and the activity evaluated as a possible cause. EXAMPLE(S): Administration of cold medicine may be evaluated as a cause of an adverse event.\nConcepts: Evaluated Activity Relationship (Qualitative Concept)\tsignal transduction involved in mitotic cell cycle G1/S transition size control checkpoint (Cell Function)\testablishment of protein localisation to chloroplast (Cell Function)\tcentral nucleus of amygdala capsular part (Body Part, Organ, or Organ Component)\tMycobacterium avium-intracellulare Complex (Mycobacterium avium Complex)", + "output": "Evaluated Activity Relationship (Qualitative Concept)" + }, + { + "input": "Definition: Molecular Function described as the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein.\nConcepts: Cardiac Valves, Mechanical (Medical Device)\tGSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine (peptidyl-serine modification)\tnitrilotriacetate dehydrogenase activity (Molecular Function)\tC165936 (Laboratory Procedure)\textrinsic component of postsynaptic endosome membrane (Cell Component)", + "output": "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine (peptidyl-serine modification)" + }, + { + "input": "Definition: Barbiturates measurement described as a measurement of the butalbital present in a biological specimen.\nConcepts: Receptor Tyrosine-Protein Kinase erbB-1 H773 V774insGH (Cell or Molecular Dysfunction)\tButalbital measurement (Barbiturates measurement)\tSafe Mtng Matl (Intellectual Product)\tFAC042-I Am Able to Work (Intellectual Product)\tdistraction (Pain Management Method)", + "output": "Butalbital measurement (Barbiturates measurement)" + }, + { + "input": "Definition: Medicine Services and Procedures described as intravenous administration of a photosensitizing agent which selectively concentrates in cancer cells, followed by exposure of the tumor to laser light of a specific wavelength; the resulting cytotoxic free radicals destroy the tumor.\nConcepts: Feeding Pumps (Medical Device)\tViruses, SSPE (Defective Viruses)\tprotein localization to kinetochore (Cell Function)\tPhotochemotherapies (Special Dermatological Procedures)\tglycocyaminase activity (Molecular Function)", + "output": "Photochemotherapies (Special Dermatological Procedures)" + }, + { + "input": "Definition: something described as an emission spectrometer that generates a high-energy spark across an argon-filled gap between an electrode and a solid sample, causing emission of radiation from the excited sample surface and resulting in wavelengths characteristic of the elemental composition.\nConcepts: lymphedemas (Disorder characterized by edema)\tBiopsy Trephines (Medical Device)\tSurface of groove for superior sagittal sinus (Subdivision of surface of skull)\tOE Spectrometer (Research Device)\tRefractory Liver Carcinoma (Neoplastic Process)", + "output": "OE Spectrometer (Research Device)" + }, + { + "input": "Definition: Human herpes simplex virus described as a species in the genus RHADINOVIRUS, subfamily GAMMAHERPESVIRINAE, isolated from patients with AIDS-related and \"classical\" Kaposi sarcoma.\nConcepts: hydrogencarbonate binding (anion binding)\tKaposi's sarcoma-associated herpesvirus (Virus)\tAnaerobic Gram-negative Rod (Microorganism)\tTwin pregnancy, monochorionic/monoamniotic (Monochorionic twin pregnancy)\tselenium-containing prosthetic group metabolic process (prosthetic group metabolic process)", + "output": "Kaposi's sarcoma-associated herpesvirus (Virus)" + }, + { + "input": "Definition: something described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated\nConcepts: MSIS-29 V1 (Intellectual Product)\tComplete or near-complete absence of isohemagglutinins (Finding)\t150-225 (Gene or Genome)\tGrade 3 Tracheitis, CTCAE (Tracheitis, CTCAE)\tGrade 3 Pelvic pain (Finding)", + "output": "Grade 3 Tracheitis, CTCAE (Tracheitis, CTCAE)" + }, + { + "input": "Definition: something described as a finding of aviremia at a specified timepoint, early during the treatment period.\nConcepts: RAPID VIROLOGIC RESPONSE (Virologic Response)\tExtent of menstrual bleeding (Menstruation)\tCaspase 12 (Caspases, Initiator)\tpositive regulation of neutrophil activation (Physiologic Function)\tnegative regulation of auxin mediated signaling pathway (Molecular Function)", + "output": "RAPID VIROLOGIC RESPONSE (Virologic Response)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Pulmonary Disorder, Fibrosis/Hermansky-Pudlak Syndrome described as molecular assay reagents intended to identify deletions and duplications in genes associated with pulmonary fibrosis and Hermansky-Pudlak syndrome, a genetic disorder that leads to signs and symptoms in multiple body systems including high rates of pulmonary fibrosis. Genetic variants at multiple loci have been associated with pulmonary fibrosis and Hermansky-Pudlak syndrome. These reagents are intended to detect deletions and duplications in multiple primary pulmonary fibrosis/Hermansky-Pudlak syndrome-associated loci simultaneously.\nConcepts: Undesired Sedation Score 7 (Intellectual Product)\tAntimalarial Drugs (Medicinal product categorized by disposition)\tHIV tat (Genes, Viral)\tKB004 monoclonal antibody (Pharmacologic Substance)\tPulmonary Fibrosis/Hermansky-Pudlak Syndrome Gene Deletion/Duplication Panel Reagents (Medical Device)", + "output": "Pulmonary Fibrosis/Hermansky-Pudlak Syndrome Gene Deletion/Duplication Panel Reagents (Medical Device)" + }, + { + "input": "Definition: something described as nasal cavity and paranasal sinuses cancer with no metastasis to regional lymph nodes.\nConcepts: Atypical choroid plexus papilloma (Glioma, uncertain whether benign or malignant)\tpositive regulation of monocyte chemotactic protein-1 production (Molecular Function)\tNasal Cavity and Paranasal Sinuses Carcinoma cN0 TNM Finding v8 (Finding)\tNephrotic Syndrome - WT1 Associated (Nephrotic Syndrome)\tIncreased collagen crosslinked N-telopeptide [Moles/volume] in 24 hour urine (Finding)", + "output": "Nasal Cavity and Paranasal Sinuses Carcinoma cN0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Organic Chemical described as an aryloxyisobutyric acid derivate with antihyperlipidemic activity. Although the exact mechanism of action has not been fully characterized, clofibrate may enhance the conversion of very-low-density lipoprotein (VLDL) to low-density lipoprotein (LDL), decreasing the production of hepatic VLDL, inhibiting cholesterol production, and increasing fecal excretion of neutral sterols. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C378\" active clinical trials using this agent.\nConcepts: clofibrate (chlorobenzene)\tanterograde dendritic transport of mRNA RNP complex (protein localization to postsynapse)\tErbovirus (Virus)\tGanglioside, GM2 (Gangliosides)\tHumeral Component Trial Prostheses (Medical Device)", + "output": "clofibrate (chlorobenzene)" + }, + { + "input": "Definition: Statistical Theory & Experimentation described as form of research methodology in which experimental variables and relationships are assigned numerical value. Used only when the methodology or research itself is the focus of discussion.\nConcepts: Clinical Faculty (Health Personnel)\tfield (Conceptual Entity)\tQuantitative Methods (Methodology)\tTRYPSIN INHIB BOWMAN (Pharmacologic Substance)\tBlasts Expressing B-Lymphoid and T-Lymphoid Markers Present (Blasts of Mixed Phenotype Present)", + "output": "Quantitative Methods (Methodology)" + }, + { + "input": "Definition: Finding described as IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated\nConcepts: Plumeria L., 1753 (Plumeriinae)\tInterspecific Recombination (Genetic Function)\tBiologic Entity Group Identifier (Intellectual Product)\tGrade 3 Endocarditis Infective, CTCAE (Endocarditis Infective, CTCAE)\tnegative regulation of telomere maintenance via telomerase (negative regulation of DNA biosynthetic process)", + "output": "Grade 3 Endocarditis Infective, CTCAE (Endocarditis Infective, CTCAE)" + }, + { + "input": "Definition: Circulatory Process described as the flow of lymph from an area of tissue into a particular lymph node.\nConcepts: GDS01-Avoid Social Gatherings (Intellectual Product)\tlymph node drainage (Organ or Tissue Function)\tVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (Receptor Tyrosine Kinase Gene)\tDemeclocycline Hydrochloride (Organic Chemical)\tMETACARPAL BONE 3 (Body Part, Organ, or Organ Component)", + "output": "lymph node drainage (Organ or Tissue Function)" + }, + { + "input": "Definition: steroid dehydrogenase activity, acting on the CH-CH group of donors described as catalysis of the reaction: a 3-oxosteroid + acceptor = a 3-oxo-D1-steroid + reduced acceptor.\nConcepts: cellotriose transport (Cell Function)\tAbnormality of the end part of the innermost bone of the big toe (Anatomical Abnormality)\tstuttered (Speech finding)\t3-ketosteroid-delta1-dehydrogenase activity (steroid dehydrogenase activity, acting on the CH-CH group of donors)\tGrade 1 White Blood Cell Decreased, CTCAE (Finding)", + "output": "3-ketosteroid-delta1-dehydrogenase activity (steroid dehydrogenase activity, acting on the CH-CH group of donors)" + }, + { + "input": "Definition: Specialized physician described as a doctor concerned with the diagnosis and treatment of skin conditions.\nConcepts: MoAb HD37-SMPT-dgA Immunotoxin (Amino Acid, Peptide, or Protein)\tMicrotias, Congenital (Congenital Abnormality)\tvitamin D response element binding (Genetic Function)\tChill(s) NOS (Transfusion Reaction)\tDermatologist (Physicians)", + "output": "Dermatologist (Physicians)" + }, + { + "input": "Definition: chemical reaction described as addition of or hydrolytic removal of an amide group.\nConcepts: Third Line Treatment (Procedure by intent)\tAmidation/Deamidation (Phenomenon or Process)\tCommon law marriage (Married)\tretrospective cohort study (Research Activity)\tDuct adenoma (Neoplastic Process)", + "output": "Amidation/Deamidation (Phenomenon or Process)" + }, + { + "input": "Definition: vasoactive agent described as a polyphenolic flavonoid with potential chemopreventive activity. Quercetin, ubiquitous in plant food sources and a major bioflavonoid in the human diet, may produce antiproliferative effects resulting from the modulation of either EGFR or estrogen-receptor mediated signal transduction pathways. Although the mechanism of action of action is not fully known, the following effects have been described with this agent in vitro: decreased expression of mutant p53 protein and p21-ras oncogene, induction of cell cycle arrest at the G1 phase and inhibition of heat shock protein synthesis. This compound also demonstrates synergy and reversal of the multidrug resistance phenotype, when combined with chemotherapeutic drugs, in vitro. Quercetin also produces anti-inflammatory and anti-allergy effects mediated through the inhibition of the lipoxygenase and cyclooxygenase pathways, thereby preventing the production of pro-inflammatory mediators.\nConcepts: Lin-54 Homolog (Biologically Active Substance)\t3''-deamino-3''-oxonicotianamine reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tQuercetin product (Vitamin)\tMalignant Urethra Tumor (Urethral Neoplasms)\tPenicillium, NOS (Form family Moniliaceae)", + "output": "Quercetin product (Vitamin)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of alpha fetoprotein L1 present in a sample.\nConcepts: Air-purifying respirator (Protective Devices)\tAlpha Fetoprotein L1 Measurement (Laboratory Procedure)\tUnaligned Reads (Sequence Analysis)\tarea 9 of Brodmann (Body Location or Region)\tPatient Oriented Research (Clinical Research)", + "output": "Alpha Fetoprotein L1 Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Intellectual Product described as a subjective score of 60% on a scale that ranges from 0%: No Relief to 100%: Complete Relief.\nConcepts: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor (Molecular Function)\tGSE - Gluten-sensitive enteropathy (Abnormality of the small intestine)\tBPI Percentage Relief From Pain Treatment or Medication Score 60 (Intellectual Product)\tIntravenous Peripheral Route of Administration (Intravenous Route of Drug Administration)\tsyndrome; XXXXX (Female with more than three X chromosomes)", + "output": "BPI Percentage Relief From Pain Treatment or Medication Score 60 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Constructional praxis task for copying a cube.\nConcepts: BOTHROPS ATROX REAGENT (Medical Device)\tFactor Maf, Transcription (Biologically Active Substance)\tConstructional Praxis: Cube (ADAS-Cog CDISC Version Questionnaire Question)\tParonychia (Infections and Infestations, CTCAE)\tTaste Bud (Tongue)", + "output": "Constructional Praxis: Cube (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: cytarabine described as an orally-active pyrimidine analogue of an aza-substituted cytidine in which the ribose moiety is replaced by an arabinose sugar. Similar in action to cytarabine, fazarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; its incorporation into DNA inhibits DNA synthesis, resulting in tumor cell death and tumor necrosis. The presence of deoxycytidine kinase in a tumor is a determinant of tumor sensitivity to this drug. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1096\" active clinical trials using this agent.\nConcepts: QS-FACT-LYM Version 4 TESTCD (Intellectual Product)\tPNEUMONOL (Biomedical Occupation or Discipline)\tCardiovascular injury (Injuries NEC)\tMollicutales (Tenericutes)\tKymarabine (Antineoplastic Agents)", + "output": "Kymarabine (Antineoplastic Agents)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Telephone Format - How much time did you usually spend doing moderate physical activities on one of those days?: Minutes per day.\nConcepts: cinnamaldehyde:oxygen oxidoreductase activity (Molecular Function)\tcongenital neuromuscular disorder (Congenital neurologic anomalies)\tCONTROLLER, ABORTION UNIT, VACUUM (Medical Device)\tIPAQ Short Last 7 Days Telephone Format Version - Moderate Physical Minutes per Day (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)\tpositive regulation of enzyme activity (Molecular Function)", + "output": "IPAQ Short Last 7 Days Telephone Format Version - Moderate Physical Minutes per Day (IPAQ Short Last 7 Days Telephone Format Version Questionnaire Question)" + }, + { + "input": "Definition: something described as an infectious disorder of newborn infants that is characterized by a systemic inflammatory response within 72 hours of life and is most commonly caused by bacteria.\nConcepts: VALG0101 (Intellectual Product)\tsepticemia of newborn early-onset (Inflammatory disorder)\tventrolateral division of the lateral nucleus of the amygdala (Body Part, Organ, or Organ Component)\tFOLFOX-6 Regimen (FOLFOX Regimen)\tIncreased G6PD level in red blood cells (Finding)", + "output": "septicemia of newborn early-onset (Inflammatory disorder)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the amino acid residue at position 545 in the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform protein where glutamic acid has been replaced by glycine.\nConcepts: Medical (General Qualifier)\tExternal Otitis (Inflammatory dermatosis)\tHanukah Factor Serine Protease (Enzyme)\tCardiac Biphasic Synovial Sarcoma (Cardiac Synovial Sarcoma)\tPIK3CA NP 006209.2:p.Glu545Gly (PIK3CA NP 006209.2:p.E545X)", + "output": "PIK3CA NP 006209.2:p.Glu545Gly (PIK3CA NP 006209.2:p.E545X)" + }, + { + "input": "Definition: regulation of nitrogen compound metabolic process described as any process that modulates the frequency, rate or extent of N',N'',N'''-triacetylfusarinine C biosynthetic process.\nConcepts: Syndrome, Omenn's (Immune system disorders congenital)\textracellular matrix protein production (Gene Expression)\tHathewaya limosa (Andre 1948) Lawson and Rainey 2016 (Clostridium)\tDENTURE ADHESIVE, CARBOXYMETHYLCELLULOSE SODIUM (Medical Device)\tregulation of N',N'',N'''-triacetylfusarinine C biosynthetic process (regulation of nitrogen compound metabolic process)", + "output": "regulation of N',N'',N'''-triacetylfusarinine C biosynthetic process (regulation of nitrogen compound metabolic process)" + }, + { + "input": "Definition: Clinical Enzyme Tests described as the determination of the amount of ceruloplasmin present in a sample.\nConcepts: tetrapyrrole anabolism (cellular nitrogen compound biosynthetic process)\tMeasurement of ceruloplasmin (Laboratory Procedure)\tHormonal therapy/ (Hormonal therapeutic procedures NEC)\tADNI AVLT - List B Recall Word 15 (Intellectual Product)\tSalmonella IV (Bacterium)", + "output": "Measurement of ceruloplasmin (Laboratory Procedure)" + }, + { + "input": "Definition: cellular diagnosis, vaginal cancer described as an adenocarcinoma arising from the vagina. Morphologic variants include the clear cell, endometrioid, mesonephric, and mucinous adenocarcinoma.\nConcepts: Average Education Level (Socioeconomic Indicator)\tInterim Analysis Datasets (Intellectual Product)\tPleural Mesothelioma pT4 TNM Finding v7 (Pleural Mesothelioma Pathologic Primary Tumor TNM Finding v7)\tNORMAN-ROBERTS SYNDROME (Classical Lissencephaly)\tvaginal adenocarcinoma (Vaginal Glandular Neoplasm)", + "output": "vaginal adenocarcinoma (Vaginal Glandular Neoplasm)" + }, + { + "input": "Definition: something described as a marked decrease in contrast enhancement that is not due to actual tumor shrinkage, but that may be due to anti-angiogenic therapy or an increase in steroid dosage.\nConcepts: d.ug/ml/(mg/g) (Quantitative Concept)\tnegative regulation of monocyte extravasation (regulation of monocyte extravasation)\tPseudoresponse (Radiologic finding)\tINTRAUTERINE DIAG (Diagnosis)\tmitotic cell cycle checkpoint (mitotic cell cycle process)", + "output": "Pseudoresponse (Radiologic finding)" + }, + { + "input": "Definition: Diagnosis described as techniques or procedures used to detect or identify specific abnormalities or characteristics of the fetus.\nConcepts: Antenatal Diagnosis (Diagnosis)\tCerebral Cortical Thinning (Pathological Conditions, Anatomical)\tpT2b TNM Finding (Finding)\tTumour of pyriform fossa (Neoplastic Process)\tCatheters, Urinary, Ureteral, Retrieval (Medical Device)", + "output": "Antenatal Diagnosis (Diagnosis)" + }, + { + "input": "Definition: Organism Function described as the behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.\nConcepts: Services, Family Planning (Midwifery)\tmating behaviour (Reproductive Behavior)\tpositive regulation of centriole-centriole cohesion (positive regulation of centrosome cycle)\tPropantheline-containing product (Medicinal product categorized by structure)\tHospital (Qualitative Concept)", + "output": "mating behaviour (Reproductive Behavior)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Proxy-administered (WHODAS 2.0 36-item Version Proxy-administered) Because of their health condition, in the past 30 days, how much difficulty did your relative have in: Getting dressed?\nConcepts: Anti-ds DNA Antibody (Antibodies, Anti-DNA)\tanatomy/physiology (Biologic Function)\tMenstrual cramps (Uterus finding)\tShock, Hemorrhagic (GENERAL VASCULAR DISORDERS)\tWD6D3 2 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)", + "output": "WD6D3 2 (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the total non-esterified fatty acids in a biological specimen.\nConcepts: FATACFR (Laboratory Procedure)\tProduct containing caspofungin (C [Preparations])\tIPA0326A (Intellectual Product)\tContent with Quality of Life (Findings-Based Question)\tDialysis Method of Administration (Agent Administration)", + "output": "FATACFR (Laboratory Procedure)" + }, + { + "input": "Definition: Organic Chemical described as a naturally occurring capsaicin analog found in the latex of the cactus Euphorbia resinifera with analgesic activity. Resiniferatoxin (RTX) binds to and activates the transient receptor potential vanilloid 1 (TRPV1), a non-selective cation channel in the plasma membrane of primary afferent sensory neurons. This increases the permeability to cations, and leads to an influx of calcium and sodium ions. This results in membrane depolarization, causing an irritant effect, followed by desensitization of the sensory neurons thereby inhibiting signal conduction in afferent pain pathways and causing analgesia. TRPV1, a member of the transient receptor potential channel (TRP) superfamily, is a heat- and chemo-sensitive calcium/sodium ion channel that is selectively expressed in a subpopulation of pain-sensing primary afferent neurons. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1214\" active clinical trials using this agent.\nConcepts: Light Sources, Photographic Station (Lights, manufactured)\tflucytosina (Other antimycotics for systemic use in ATC)\tresiniferatoxin (Organic Chemical)\tSunset Syndrome (Syndrome)\tJoint Vendor Oversight Plan (Intellectual Product)", + "output": "resiniferatoxin (Organic Chemical)" + }, + { + "input": "Definition: Molecular Function described as the act of ligating UBIQUITINS to PROTEINS to form ubiquitin-protein ligase complexes to label proteins for transport to the PROTEASOME ENDOPEPTIDASE COMPLEX where proteolysis occurs.\nConcepts: D70 FAMILY LINACEAE (Malpighiales)\tAmputation - action (removal technique)\tprotein ubiquitylation (Post-Translational Protein Processing)\tOxylipin Metabolome (Metabolic marker)\tregulation of meiotic metaphase/anaphase transition (Molecular Function)", + "output": "protein ubiquitylation (Post-Translational Protein Processing)" + }, + { + "input": "Definition: something described as surface tension of the surfaces at the boundary between two immiscible liquids.\nConcepts: Neuronal Acetylcholine Receptor Subunit Alpha-5 (Receptor)\teukaryotic translation initiation factor 3 complex, eIF3m (eukaryotic translation initiation factor 3 complex location)\tInterfacial Force (Natural Phenomenon or Process)\td4T (Pharmacologic Substance)\tmucoepidermoid carcinoma of lung (Carcinoma of lung)", + "output": "Interfacial Force (Natural Phenomenon or Process)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as killer cell immunoglobulin-like receptor 2DL3 (341 aa, ~38 kDa) is encoded by the human KIR2DL3 gene. This protein is involved in the modulation of natural killer cell-mediated immunity.\nConcepts: CD158 Antigen-Like Family Member B2 (Receptor)\tFLJ10520 (FA Complementation Group Gene)\tPerineal structure (Specific site descriptor)\tADAMTS Protease (ADAM Proteins)\ttriglyceride-rich lipoprotein particle clearance (plasma lipoprotein particle clearance)", + "output": "CD158 Antigen-Like Family Member B2 (Receptor)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as RNA molecules found in the nucleus either associated with chromosomes or in the nucleoplasm.\nConcepts: PPBP Gene Product (Immunologic Factor)\tMycobacterium tuberculosis IgE Antibody Measurement (Laboratory Procedure)\t43 (Body Location or Region)\tSeminal Vesicle Adenocarcinoma (Neoplastic Process)\tNuclear RNA (Biologically Active Substance)", + "output": "Nuclear RNA (Biologically Active Substance)" + }, + { + "input": "Definition: Mental Processes described as temporal duration of concentration or amount of material grasped during exposure to stimuli or information. Compare ATTENTION.\nConcepts: TUBE, SINGLE LUMEN, W MERCURY WT BALLOON FOR INTES. INTUB. &/OR DECOMPRESSION (Medical Device)\tSpecificity, Antibody (Immune System Phenomena)\tVacuuming Carpets 5 Minutes Nonstop (Clinical or Research Assessment Question)\tDiseases, Coronary (Myocardial Ischemia)\tAttention Span (Sustained attention)", + "output": "Attention Span (Sustained attention)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with glucomannan.\nConcepts: Graves Disease (Thyroid hyperfunction disorders)\tglucomannan binding (drug binding)\tALK Rearrangement (Gene Rearrangement)\tBRAF Protein (Biologically Active Substance)\tImmature Retinopathy of Prematurity (Finding)", + "output": "glucomannan binding (drug binding)" + }, + { + "input": "Definition: something described as asymmetries in the topography and refractive index of the corneal surface that affect visual acuity.\nConcepts: Corneal Wavefront Aberrations (Corneal Diseases)\tRAD50 Homolog (S. cerevisiae) Gene Mutation (Cell or Molecular Dysfunction)\tmethionine transport (cation transport)\tIncubator, infant (Incubators)\tRanunculales (Plant)", + "output": "Corneal Wavefront Aberrations (Corneal Diseases)" + }, + { + "input": "Definition: Molecular Function described as a series of actions among molecules in a cell that leads to a certain end point or cell function.\nConcepts: Exposure as Collected Sequence Number (Sequence Number)\tDiscrimination (Social Behavior)\t327 DIVERTICULA (Other Finding)\tDisease, Cerebellar (Spinocerebellar Degeneration)\tPathway (Molecular Function)", + "output": "Pathway (Molecular Function)" + }, + { + "input": "Definition: something described as fetal heart detectors that use ultrasonic waves to provide audible and/or visual information. They consist of an ultrasound-frequency electrical generator and appropriate ultrasound transducers housed in a probe that is placed on the maternal abdomen. Ultrasonic heartbeat detectors amplify the audible frequency shift (i.e., Doppler effect) signal of the returned ultrasonic waves and deliver it to speakers or headphones; the heart rate is determined either by measuring the timing of the peaks in the Doppler signal or, more accurately, by using automated autocorrelation procedures. These devices can detect fetal heart activity as soon as 10 weeks after conception.\nConcepts: age cells (cell life cycle)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CHRNB2 (Medical Device)\tInformal relationships with neighbours (Social Behavior)\tFetal heart detector, ultrasonic (Medical Device)\tmol*h/mL (Quantitative Concept)", + "output": "Fetal heart detector, ultrasonic (Medical Device)" + }, + { + "input": "Definition: CDISC Standard described as an implementation of the CDISC SDTM standard for the collection and storage of nonclinical study data.\nConcepts: Forssman synthase activity (acetylgalactosaminyltransferase activity)\tONCHOCERCA VOLVULUS (Onchocerca)\tblood stasis (Finding)\tNursing & Custodial Care Facilities; Assisted Living Facility, \"Assisted Living, Behavioral Disturbances\" (Manufactured Object)\tSEND (CDISC Standard)", + "output": "SEND (CDISC Standard)" + }, + { + "input": "Definition: something described as a long-acting loop diuretic. Etozolin appears to be rapidly metabolized to its active metabolite ozolinone.\nConcepts: Not applicable; I have not smoked cigarettes since my diagnosis (Finding)\tmulticellular organismal signaling (multicellular organismal process)\tETOZOLIN (Other high-ceiling diuretics in ATC)\tNCCN-FACT FBRSI-24 Version 2 - I Need Help in Caring for Myself (Intellectual Product)\tleaf senescence (Organism Function)", + "output": "ETOZOLIN (Other high-ceiling diuretics in ATC)" + }, + { + "input": "Definition: Bovine papillomavirus group, NOS described as a virus that infects some types of monkeys. It may also infect humans, and was found in some polio vaccines tested in the early 1960s. Although the virus has been shown to cause cancer in laboratory animals, there is no evidence that it causes cancer in people.\nConcepts: Collaborative Cross Mice (Mice, Inbred Strains)\tCRQ0109 (Intellectual Product)\tSEACIT complex location (protein-containing complex)\tRibosomal Protein L13a Gene (Gene or Genome)\tSV 40 Virus (Virus)", + "output": "SV 40 Virus (Virus)" + }, + { + "input": "Definition: something described as a finding in an esophageal biopsy specimen indicating the diagnosis of Barrett esophagus associated with the presence of metaplastic non-goblet cell columnar epithelium.\nConcepts: Full Body Flexibility Exercisers (Manufactured Object)\tPrephase Chemotherapy Treatment (Chemotherapy)\tAbnormal GPRT level (Finding)\tBarrett Esophagus With Metaplastic Non-Goblet Cell Columnar Epithelium (Abnormal Tissue Present)\tEstrone Measurement (17-Ketosteroids measurement)", + "output": "Barrett Esophagus With Metaplastic Non-Goblet Cell Columnar Epithelium (Abnormal Tissue Present)" + }, + { + "input": "Definition: something described as expanded Disability Rating Scale - Postacute Interview Caregiver Version - How certain are you that [name] can perform in a wide variety of jobs of [his/her] choosing or manage a home independently or participate in school full-time?\nConcepts: Spherophorus necroticus (Genus Fusobacterium)\tMatrix Metalloprotease 13 (Amino Acid, Peptide, or Protein)\tregulation of glutamate secretion, neurotransmission (regulation of neurotransmitter secretion)\tED108 4 (Expanded DRS-PI Caregiver Version Questionnaire Question)\tvomits (Clinical or Research Assessment Question)", + "output": "ED108 4 (Expanded DRS-PI Caregiver Version Questionnaire Question)" + }, + { + "input": "Definition: Computer Software Problem described as problem associated with the deviations from documented system specifications that affects overall system performance and/or the performance of an individual device connected to that system.\nConcepts: Testosterone Less than or Equal to 50 ng/dL (Testosterone Level Finding)\tCranial base width (Fiat anatomical line of head)\tRicinus Lectin (Albumins)\tApplication Network Problem (Finding)\tPODCI Adolescent Self-Reported Version - Outdoor Limited by: Health (PODCI Adolescent Self-Reported Version Questionnaire Question)", + "output": "Application Network Problem (Finding)" + }, + { + "input": "Definition: Angular described as position of the X-ray beam about the patient from the RAO to LAO direction where movement from RAO to vertical is positive.\nConcepts: Apicoposterior segmental vein (Pulmonary veins)\tPBD3B (Peroxisome biogenesis disorders)\tselenite:reduced acceptor oxidoreductase activity (Molecular Function)\tPositioner Primary Angle (Angular)\tOxidase, Dihydro-Orotate (Amino Acid, Peptide, or Protein)", + "output": "Positioner Primary Angle (Angular)" + }, + { + "input": "Definition: DNA-templated transcription, termination described as the process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.\nConcepts: Transmembrane Protein 127 (Biologically Active Substance)\tDecolorization, Water (Water Purification)\tMethylobacterium Patt et al. 1976 (Approved Lists 1980) emend. Green and Bousfield 1983 (Methylobacterium)\tRNA polymerase II transcription termination (DNA-templated transcription, termination)\tAnkyloglossia congenital (Frenulum of tongue finding)", + "output": "RNA polymerase II transcription termination (DNA-templated transcription, termination)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a portion of the pontine nuclei located in the midline between the medial lemniscus of the two sides in the basal pons of the mouse ( Paxinos-2001 ).\nConcepts: dorsomedial pontine nucleus (Body Part, Organ, or Organ Component)\tplasma membrane-derived chromatophore (Cell Component)\tSegmental demyelination/remyelination (Peripheral Nervous System)\tProstheses, Dental, Fixed, Partial (Prostheses, Dental, Fixed)\tdownregulation of light-activated channel activity (negative regulation of ion transmembrane transporter activity)", + "output": "dorsomedial pontine nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Multiple malformation syndrome with facial defects as major feature described as an ectodermal dysplasia syndrome with characteristics of severe arthrogryposis, multiple ectodermal dysplasia features, cleft lip/palate, facial dysmorphism, growth deficiency and a moderate delay of psychomotor development. Ectodermal dysplasia manifestations include sparse, brittle and hypopigmented hair, xerosis, multiple naevi, small conical shaped teeth and hypodontia, and facial dysmorphism with blepharophimosis, deep-set eyes and micrognathia.\nConcepts: Congenital contractures, ectodermal dysplasia, cleft lip-palate, and developmental impairment (Multiple malformation syndrome with facial defects as major feature)\tCYP2E1 Inhibitors, P450 (Cytochrome P-450 Enzyme Inhibitors)\tAphysiostroma (Ascomycota)\tCirculating Clonotypic B-Lymphocyte (Neoplastic B-Lymphocyte)\tImmediate Release Tablet Dosage Form (Biomedical or Dental Material)", + "output": "Congenital contractures, ectodermal dysplasia, cleft lip-palate, and developmental impairment (Multiple malformation syndrome with facial defects as major feature)" + }, + { + "input": "Definition: Genetic Diseases, Inborn described as immunodeficiency disease that arises independent of another pathologic process, disease, or injury.\nConcepts: Primary immunodeficiency syndrome (Disease or Syndrome)\tgallium Ga 68-NODAGA-E(c[RGDyK])2 (Indicator, Reagent, or Diagnostic Aid)\trubella vaccination (human vaccination)\tP190A (Gene or Genome)\tcysteine-type endopeptidase activity involved in apoptotic process (cysteine-type endopeptidase activity)", + "output": "Primary immunodeficiency syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: something described as treatment Satisfaction Questionnaire for Medication Version 1.4 test code.\nConcepts: CDISC Questionnaire TSQM Version 1.4 Test Code Terminology (Intellectual Product)\tPerformed Observation Target Anatomic Site Laterality Code (Target Anatomic Site Laterality Code)\tBPI Percentage Relief From Pain Treatment or Medication Likert Scale (Research or Clinical Assessment Tool)\tmodification by virus of host protein function (Cell Function)\tFowlpox virus antibody (Immunologic Factor)", + "output": "CDISC Questionnaire TSQM Version 1.4 Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: Indolequinones described as any of a class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis.\nConcepts: Hemiplegia (CNS GENERAL)\tregulation of endothelial cell migration (Cell Function)\tPenile Cancer pT4 TNM Finding v8 (Finding)\tmitomycin (Azirines)\tAcute monoblastic/monocytic leukemia, in relapse (Recurrent Acute Myeloid Leukemia Not Otherwise Specified)", + "output": "mitomycin (Azirines)" + }, + { + "input": "Definition: Nonverbal Communication described as an involuntary expression of merriment and pleasure; it includes the patterned motor responses as well as the inarticulate vocalization.\nConcepts: Distal Bile Duct Cancer pT2 TNM Finding v7 (Finding)\tLAUGHING (Social Behavior)\tlarval turning behaviour (Individual Behavior)\tNevus Syndrome, Basal Cell (Skin and subcutaneous tissue disorders congenital NEC)\tQ-LES-Q - Felt Well Coordinated (Q-LES-Q Questionnaire Question)", + "output": "LAUGHING (Social Behavior)" + }, + { + "input": "Definition: Piperazine and derivatives, antinematodal agents described as a cyclic organic compound possessing two nitrogen atoms in opposite positions within a 6-member heterocyclic ring that serves as a backbone for piperazine derivatives and acts as a gamma-amino-butyric acid (GABA) receptor agonist in nematodes, with potential anti-helminthic activity. Upon administration, piperazine binds to the GABA inhibitory receptors in susceptible nematodes, thereby inducing chloride channel opening and hyperpolarization. This results in paralysis of the worm musculature and allows normal peristalsis to dislodge the worm from the intestinal lumen, which causes the worm to be expelled from the body. Unlike vertebrates where GABA is restricted to the central nervous system (CNS), the GABA receptors in helminths are also expressed in the peripheral nervous system.\nConcepts: RS (Yugoslavia)\tProbable Phospholipid-Transporting ATPase ID (Translocase)\tpiperazine preparations (Piperazine derivative)\tPKM2 (Laboratory Procedure)\tResults Submission Date (Temporal Concept)", + "output": "piperazine preparations (Piperazine derivative)" + }, + { + "input": "Definition: something described as a protein complex that contains ezrin, Na+/H+ exchanger regulatory factor (NHERF, also called EBP50), and two copies of the cystic fibrosis transmembrane conductance regulator (CFTR). The CFTR molecules interact with NHERF via their cytoplasmic tail domains; the complex is thought to link the CFTR channel to the actin cytoskeleton and contribute to the regulation of channel activity.\nConcepts: VIROL (Science of Microbiology)\tdown-regulation of antiviral response (regulation of defense response to virus)\tCFTR-NHERF-ezrin complex location (Cell Component)\tPostal code (Code)\tAbsence of Bowel Movement (Disturbance in Bowel Function)", + "output": "CFTR-NHERF-ezrin complex location (Cell Component)" + }, + { + "input": "Definition: something described as clinical chemistry reagents consisting of serum pooled either from donors with normal levels of lipoproteins or from disease-state donors with above-normal concentrations of total lipoproteins or of some specific lipoproteins; less frequently, they are obtained by extracting some lipoproteins from normal donor serum (i.e., lipoprotein-deficient serum). Lipoprotein control reagents are mostly used for quality control of specific lipoprotein assays performed in a sample of a body fluid.\nConcepts: Ovarian Carcinoma by AJCC v6 and v7 Stage (Carcinoma, Ovarian Epithelial)\tinterstitial myositis (Myositis)\tPolyelectrolytes (Electrolytes)\tIVD Test Reagent/Kits, Clinical Chemistry, Control, Serum, Lipoprotein (Medical Device)\tAPTTLAAC (Laboratory Procedure)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Control, Serum, Lipoprotein (Medical Device)" + }, + { + "input": "Definition: something described as unified Parkinson's Disease Rating Scale - Modified Hoehn and Yahr Staging.\nConcepts: tigapotide (Antineoplastic Agents)\tClinical Batch (Manufactured Object)\tInterferon Gamma Receptor Complex (Receptor)\tOral/rectal solution (Oral Solution)\tUPDRS - Modified Hoehn and Yahr Staging (UPDRS Questionnaire Question)", + "output": "UPDRS - Modified Hoehn and Yahr Staging (UPDRS Questionnaire Question)" + }, + { + "input": "Definition: Immunology described as a protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). Each antibody can bind to only one specific antigen. The purpose of this binding is to help destroy the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.\nConcepts: Antibody, NOS (Immunology)\tUndifferentiated Carcinoma of Urethra (Undifferentiated carcinoma)\tLumbosacral Spine Neoplasm (Neoplastic Process)\tIntravesical suspension (Biomedical or Dental Material)\tExtent Have Trouble Having Social Contact with Family (Intellectual Product)", + "output": "Antibody, NOS (Immunology)" + }, + { + "input": "Definition: Intellectual Product described as quality of Life Enjoyment and Satisfaction Questionnaire-Short Form (Q-LES-Q-SF) Taking everything into consideration, during the past week how satisfied have you been with your: economic status?\nConcepts: Bowman Membranes (Corneal membrane)\tglyco hemoglobin (Laboratory Procedure)\tEmployed (Personal Attribute)\tI worry that getting pregnant (again) would take too much time and effort (Clinical or Research Assessment Question)\tQLES2-Economic Status (Q-LES-Q-SF Questionnaire Question)", + "output": "QLES2-Economic Status (Q-LES-Q-SF Questionnaire Question)" + }, + { + "input": "Definition: Organ component of esophagus described as the layer of muscularis mucosa in the esophageal wall. It is thicker than the muscularis mucosa of the stomach and intestine. It is composed of longitudinal muscle fibers.\nConcepts: Lamina muscularis of oesophageal mucous membrane (Esophageal mucous membrane)\tPQL1803 (Intellectual Product)\tNeedle (Shapes)\tOocyte Maturation Pathway (Organ or Tissue Function)\tRondonia (Geographic Area)", + "output": "Lamina muscularis of oesophageal mucous membrane (Esophageal mucous membrane)" + }, + { + "input": "Definition: Manufactured Object described as any device made from a fiber with a hollow center, particularly those for cell propagation in culture.\nConcepts: WHODAS 2.0 12-item Version Interviewer-administered - Walking a Long Distance (WHODAS 2.0 12-item Version Interviewer-administered Questionnaire Question)\tHollow Fiber Device (Manufactured Object)\tIVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis B, Antigen (IVD Test Reagent/Kits, Serology, Bacteria, Neisseria meningitidis, Antigen)\tLiter/Day (SI units of volume per unit time)\tNon-Neoplastic Intestinal Disorder (Non-Neoplastic Digestive System Disorder)", + "output": "Hollow Fiber Device (Manufactured Object)" + }, + { + "input": "Definition: something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version - Naming task for fingers of the dominant hand, little finger or pinky.\nConcepts: CSS0514A (Intellectual Product)\tADCOFF05 (ADAS-Cog CDISC Version Questionnaire Question)\tSteel, Stainless (Preformed crown material)\tregulation of thymic lymphocyte migration (regulation of T cell migration)\tWater retention (Fluid Balance)", + "output": "ADCOFF05 (ADAS-Cog CDISC Version Questionnaire Question)" + }, + { + "input": "Definition: something described as connected_to relation which holds between each anatomical entity of type A and some anatomical entity of type B such that there is no bona fide boundary between their contiguous constitutional parts.\nConcepts: Leg Extension Pneumatic Exercisers (Exercisers, Muscle Strength, Pneumatic, Lower Limb)\tAnatomical continuity (Connected to relation)\tblood disorder pharmacotherapy (Therapeutic or Preventive Procedure)\tStabyhoun (Sporting Breed)\tOther ambulatory visit (Finding)", + "output": "Anatomical continuity (Connected to relation)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 6p\nConcepts: beta-L-rhamnosidase activity (Molecular Function)\t6p12-p11.1 (Chromosome band)\tcellular response to latrunculin B (cellular response to alcohol)\tscreen failure (Trial Screening)\tinhibition of neuroepithelial cell differentiation (regulation of embryonic development)", + "output": "6p12-p11.1 (Chromosome band)" + }, + { + "input": "Definition: something described as duplication of all or part of the first ray.\nConcepts: Stewart-Morel-Morgagni syndrome (Hyperostosis)\tFACIT-Dyspnea 10 Item Short Form - Part II: Lifting 10-20 Lbs (Intellectual Product)\trRNA transcription (ncRNA transcription)\tpT3 Carcinoma of the Stomach v6 (Finding)\tPreaxial foot polydactyly (Polydactyly of toes)", + "output": "Preaxial foot polydactyly (Polydactyly of toes)" + }, + { + "input": "Definition: Pharmacologic Substance described as subtype 4 of botulinum neurotoxin serotype E.\nConcepts: BPI - Things that Make your Pain Worse (BPI Questionnaire Question)\tMHBODSYS (Body System)\tSubmission.statusCode (Code)\tRiboprinting (Molecular Biology Research Technique)\tBOTULINUM NEUROTOXIN E4 (Pharmacologic Substance)", + "output": "BOTULINUM NEUROTOXIN E4 (Pharmacologic Substance)" + }, + { + "input": "Definition: cytosolic tricarboxylic acid cycle enzyme complex described as cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity.\nConcepts: regulation of interleukin-8 production (Organism Function)\torganic cyclic compound metabolic process (organic substance metabolic process)\t5: 135259415-135255834 (Chromosome 5 Physical Location)\tMouflon (UNGULATES - HOOFED MAMMALS)\tcytosolic isocitrate dehydrogenase complex (Cell Component)", + "output": "cytosolic isocitrate dehydrogenase complex (Cell Component)" + }, + { + "input": "Definition: Antineoplastic Agents described as a very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.\nConcepts: Recurrent Oral Cavity Adenoid Cystic Carcinoma (Adenoid cystic carcinoma of the oral cavity)\t(8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-\u03b1-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione (Anthracycline Topoisomerase Inhibitor [EPC])\tUrethral Cancer TNM Finding v7 (Genitourinary System Cancer TNM Finding v7)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, FGF23 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tHistory, Medieval (Temporal Concept)", + "output": "(8S-cis)-8-acetyl-10-((3-amino-2,3,6-trideoxy-\u03b1-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione (Anthracycline Topoisomerase Inhibitor [EPC])" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is or was bothered by lumps or swelling in certain parts of their body.\nConcepts: Bothered by Lumps or Swelling in Certain Parts of My Body (Clinical or Research Assessment Question)\tEosinophilia Greater than 1500 cells/ul (Laboratory or Test Result)\ttertiary prevention (Public Health Practice)\tFTOC (Research Activity)\tQLES105 (Intellectual Product)", + "output": "Bothered by Lumps or Swelling in Certain Parts of My Body (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Immunoconjugates described as an antibody-drug conjugate (ADC) composed of a monoclonal antibody directed against an as of yet undisclosed tumor-associated antigen (TAA) linked to an undisclosed cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, the monoclonal antibody moiety of ABBV-011 targets and binds to the TAA expressed on tumor cells. Upon binding and internalization, the cytotoxic agent is released and kills tumor cells expressing this particular TAA through an as of yet undisclosed mechanism.\nConcepts: Adriamycin/Solu-Medrol/High-dose Ara-C/Platinol/Methotrexate/Bleomycin/Cyclophosphamide/Oncovin (Regimen Used to Treat Non-Hodgkin Lymphoma)\tABBV 011 (Immunologic Factor)\tCombretastatin A-4 phosphate (Colchicine-Site Binding Agent)\tCongenital pes valgo planus (Congenital flat foot)\tabscess rectal (Lesion of rectum)", + "output": "ABBV 011 (Immunologic Factor)" + }, + { + "input": "Definition: Dental Diseases described as a pocket of pus located within a region of a tooth.\nConcepts: Caput of sperm (cellular anatomical entity)\tabscessed tooth (Mass of oral cavity)\tSertoli cell fate commitment (epithelial cell fate commitment)\tP2Y6 nucleotide receptor binding (Molecular Function)\tp78-Related Protein (Amino Acid, Peptide, or Protein)", + "output": "abscessed tooth (Mass of oral cavity)" + }, + { + "input": "Definition: Intellectual Product described as deployment Risk & Resilience Inventory-2 - During deployment, the people I worked with: questioned my abilities or commitment to perform my job effectively.\nConcepts: Holotricha (Ciliophora)\tProprioceptive-induced seizure (Reflex seizure)\tAltretamine/Cisplatin/Cyclophosphamide/Fluorouracil (Therapeutic or Preventive Procedure)\tDRRI1-K: Questioned My Abilities Perform (DRRI-2 Questionnaire Question)\tDymenorrhea [dup] (Female Reproductive System)", + "output": "DRRI1-K: Questioned My Abilities Perform (DRRI-2 Questionnaire Question)" + }, + { + "input": "Definition: Neuropathy described as damage to the optic nerve.\nConcepts: Optic neuropathy (Disorder of visual pathways)\tPASAT1-Total Correct in Second Half (PASAT Functional Test Question)\tkymography (Diagnostic Techniques and Procedures)\tregulation of septum digestion after cytokinesis (regulation of cell division)\tindoleacetic acid formation via tryptophan (indoleacetic acid biosynthetic process)", + "output": "Optic neuropathy (Disorder of visual pathways)" + }, + { + "input": "Definition: Non-Manometric Unit of Pressure described as a unit of resistance equal to the number of kilopascals per unit of volume equal to one liter per unit of time equal to one second.\nConcepts: FNTB wt Allele (Gene or Genome)\tPurple Grape Juice (Fruit Juices)\tKilopascals/liter/second (Non-Manometric Unit of Pressure)\tMyocardium of wall of outflow part of left atrium (Set of organ components of heart)\tup-regulation of UDPGT activity (positive regulation of transferase activity)", + "output": "Kilopascals/liter/second (Non-Manometric Unit of Pressure)" + }, + { + "input": "Definition: Quantitative Concept described as physically available beds = Staffed + Unstaffed beds Beds that are licensed, physically set up, and available for use. These are beds regularly maintained in the hospital for the use of patients, which furnish accommodations with supporting services (such as food, laundry, and housekeeping). These beds may or may not be staffed but are physically available.\nConcepts: Physically available beds (Quantitative Concept)\tRat Anatomy (Classification)\tColumbia-Suicide Severity Rating Scale Children's Since Last Visit Questionnaire Test Name (Intellectual Product)\tadult non-Hodgkin's lymphoma, stage I (Adult Non-Hodgkin's Lymphoma Stage)\tEthanaminium, 2,2',2''-(1,2,3-benzenetriyltris(oxy))tris(N,N,N-triethyl)-, triiodide (Nondepolarizing neuromuscular blocker product)", + "output": "Physically available beds (Quantitative Concept)" + }, + { + "input": "Definition: Congenital Abnormality described as incisor that has marked lateral borders occurring lingually.\nConcepts: PASI0110 (Intellectual Product)\tlactose unit(s) (Quantitative Concept)\tSINODONTY (Congenital Abnormality)\tTextus (body fluid, tissue)\tmin*mg/mL/(kg/m2) (Quantitative Concept)", + "output": "SINODONTY (Congenital Abnormality)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of myotube cell migration.\nConcepts: NEUROFIBROMATOSIS (Hereditary Diseases)\tTrial Operations Subcategory (Document type)\tAutoinflammatory Disease due to Interleukin-1 Receptor Antagonist Deficiency (Autoinflammatory Syndrome)\tHypopharyngeal Cancer pT4a TNM Finding V6 (Hypopharyngeal Cancer Pathologic Primary Tumor TNM Finding v6)\tregulation of myotube cell migration (regulation of cell migration)", + "output": "regulation of myotube cell migration (regulation of cell migration)" + }, + { + "input": "Definition: something described as a process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism.\nConcepts: envenomation resulting in cytolysis in other organism (envenomation resulting in modulation of process in other organism)\tUltrasound Mode (Functional Concept)\tSafety and Clinical Database Reconciliation Document (Document type)\tPituitary Agent (Hormone)\tClass I Histocompatibility Antigen-Like Protein (Immunologic Factor)", + "output": "envenomation resulting in cytolysis in other organism (envenomation resulting in modulation of process in other organism)" + }, + { + "input": "Definition: Organization described as an educational institution for children that precedes kindergarten.\nConcepts: Clavicep (Clavicipitaceae)\tu[IU]/ml/(mg/m2) (Unit of concentration)\tPreschool (Manufactured Object)\tTransmembrane Protein 74B wt Allele (Gene or Genome)\tcitronellyl-CoA ligase activity (Molecular Function)", + "output": "Preschool (Manufactured Object)" + }, + { + "input": "Definition: something described as single term to describe two or more medicinal products that are packaged together and marketed under a single license, and which are intended to be administered independently, as separate pharmaceutical products.\nConcepts: GTP (nucleoside triphosphate)\tEuropean Directorate for the Quality of Medicines and HealthCare Combined Pack (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CTNS (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tsedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity (transferase activity, transferring aldehyde or ketonic groups)\tNeedles, Suture, Ophthalmic (Ophthalmic device)", + "output": "European Directorate for the Quality of Medicines and HealthCare Combined Pack (Intellectual Product)" + }, + { + "input": "Definition: something described as a measurement of the tissue plasminogen activator antigen in a biological specimen.\nConcepts: INSULINR (Mixed Category Laboratory Procedure)\tRhizopus (Mucorales)\tguanosine-triphosphate guanylyltransferase activity (guanylyltransferase activity)\tGTF3C1 Gene (Gene or Genome)\tTissue Plasminogen Activator Antigen (Laboratory Procedure)", + "output": "Tissue Plasminogen Activator Antigen (Laboratory Procedure)" + }, + { + "input": "Definition: Mental Process described as general mental functions, as they develop over the life span, required to understand and constructively integrate the mental functions that lead to the formation of the interpersonal skills needed to establish reciprocal social interactions, in terms of both meaning and purpose.\nConcepts: G Antigen 5 wt Allele (Gene or Genome)\tOval pupil (Deformed Pupil)\tanastomosis (Operative Surgical Procedures)\tVena cephalica antebrachii (Upper arm)\tGlobal psychosocial functions (Global mental functions)", + "output": "Global psychosocial functions (Global mental functions)" + }, + { + "input": "Definition: 10 Meter Walk/Run Functional Test Question described as ten Meter Walk/Run - Time to walk or run 10 meters.\nConcepts: Insula posterior (Body Location or Region)\trela (Idea or Concept)\tXLCART001 (Cell)\tVDCC, T-Type (Biologically Active Substance)\tTENMW1-Time to Walk/Run 10 Meters (10 Meter Walk/Run Functional Test Question)", + "output": "TENMW1-Time to Walk/Run 10 Meters (10 Meter Walk/Run Functional Test Question)" + }, + { + "input": "Definition: something described as the parts of a macromolecule that directly participate in its specific combination with another molecule.\nConcepts: Platelet Derived Growth Factor IsoformAB (Laboratory Procedure)\tstage tumor (Disease Qualifier)\treceptor sites (RECEPTOR SITES: GENERAL TERMS)\ttooth germ (Tooth Components)\tHAQ-DI With VAS - Able to Cut Meat (Intellectual Product)", + "output": "receptor sites (RECEPTOR SITES: GENERAL TERMS)" + }, + { + "input": "Definition: Radiosurgery described as a treatment using gamma rays, a type of high-energy radiation that can be tightly focused on small tumors or other lesions in the head or neck, so very little normal tissue receives radiation. The gamma rays are aimed at the tumor from many different angles at once, and deliver a large dose of radiation exactly to the tumor in one treatment session. This procedure is a type of stereotactic radiosurgery. Gamma Knife therapy is not a knife and is not surgery. Gamma Knife is a registered trademark of Elekta Instruments, Inc.\nConcepts: Pagets Disease, Breast (Neoplasms, Ductal, Lobular, and Medullary)\tphycobilin (Organic Chemical)\tGamma Knife (Radiosurgery)\tEvaporation Purification (Laboratory Procedure)\tchlorate transmembrane transporter activity (inorganic anion transmembrane transporter activity)", + "output": "Gamma Knife (Radiosurgery)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a cyclin A subtype primarily found in male GERM CELLS. It may play a role in the passage of SPERMATOCYTES into meiosis I.\nConcepts: BPI2-Treatments Receiving for Pain (Intellectual Product)\tCyclin A1 (Amino Acid, Peptide, or Protein)\tGrade 4 Pancreatic Duct Stenosis, CTCAE (Pancreatic Duct Stenosis, CTCAE)\tAbsent without Leave (Hospitalization Event)\tThickened helix (Finding)", + "output": "Cyclin A1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of alkane biosynthetic process.\nConcepts: up-regulation of alkane biosynthesis (positive regulation of cellular biosynthetic process)\thistone cluster 1, H2bd (Gene or Genome)\tisopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine (Molecular Function)\tencephalomyocarditis virus (Non human viruses)\tLarge cell medulloblastoma (Primary malignant neoplasm)", + "output": "up-regulation of alkane biosynthesis (positive regulation of cellular biosynthetic process)" + }, + { + "input": "Definition: something described as apoptosis-stimulating of p53 protein 2 (1128 aa, ~126 kDa) is encoded by the human TP53BP2 gene. This protein plays a role in cell cycle arrest and the regulation of cellular tumor antigen p53-dependent apoptosis.\nConcepts: Lazy eye (Vision Disorders)\ttonometers (Ophthalmological equipment)\theterochromatin maintenance (heterochromatin organization involved in chromatin silencing)\tFetal virilism (Reproductive tract disorders congenital NEC)\tp53-Binding Protein 2 (Biologically Active Substance)", + "output": "p53-Binding Protein 2 (Biologically Active Substance)" + }, + { + "input": "Definition: Rash Pustular, CTCAE described as localized; local intervention indicated\nConcepts: Ezetimibe/Simvastatin (HMG CoA reductase inhibitors in combination with other lipid modifying agents)\tGrade 2 Rash pustular (Rash Pustular, CTCAE)\tGovernment Publications as Topic (Intellectual Product)\tINDONESIAN (Malayo-Polynesian language)\tC3 Glomerulopathy with Monoclonal Gammopathy (Disease or Syndrome)", + "output": "Grade 2 Rash pustular (Rash Pustular, CTCAE)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the World Health Organization Disability Assessment Schedule 2.0 12-item Version Interviewer-administered (WHODAS 2.0 12-item Version Interviewer-administered) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: serum tumor marker test (Biomarker Analysis)\tGrade 1 Shingles, CTCAE (Finding)\t1 OF 5 (Finding)\tenvironmental carcinogenesis (Carcinogenesis Mechanism)\tCDISC Questionnaire WHODAS 2.0 12-item Version Interviewer-administered Test Name Terminology (CDISC Questionnaire Terminology)", + "output": "CDISC Questionnaire WHODAS 2.0 12-item Version Interviewer-administered Test Name Terminology (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as perque(TM) Magnesium Plus 650 mg each 180 caplets. UPC Code 791760029102.\nConcepts: Perque(TM) Magnesium Plus 650 mg each 180 caplets (Clinical Drug)\tTombusviridae (Positive-Strand RNA Viruses)\tHAMD 24 - Weight Loss (Intellectual Product)\tVideo Digitizers (Digitizers)\tHONDURAS (Central America)", + "output": "Perque(TM) Magnesium Plus 650 mg each 180 caplets (Clinical Drug)" + }, + { + "input": "Definition: something described as a type of epidermal acanthosis characterized by a jagged (sawtooth) appearance of the rete ridges of the epidermis.\nConcepts: arterial morphogenesis (Organ or Tissue Function)\tSawtooth acanthosis (Acanthosis)\tDogs, Working (Animals, Domestic)\tCSR Synopsis (Intellectual Product)\tCutaneous Neurocristic Hamartoma (Hamartoma)", + "output": "Sawtooth acanthosis (Acanthosis)" + }, + { + "input": "Definition: FACIT-F Version 4 Questionnaire Question described as functional Assessment of Chronic Illness Therapy-Fatigue Version 4 (FACIT-F Version 4) Additional Concerns: I feel listless ('washed out').\nConcepts: Congenital atresia of trachea (Congenital Abnormality)\tFAC071-I Feel Listless (FACIT-F Version 4 Questionnaire Question)\tCumulative Accrual (Quantitative Concept)\tMyrtus communis (Oils, Volatile)\tup regulation of mitotic sister chromatid arm separation (Cell Function)", + "output": "FAC071-I Feel Listless (FACIT-F Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Acid-base balance regulation described as promotion of acid-base balance and prevention of complications resulting from serum PaCO2 levels higher than desired or serum hydrogen ion levels higher than desired\nConcepts: Chronic sleeping sickness (African Trypanosomiasis)\tAcid-base regulation: respiratory acidosis (Electrolyte and Acid-Base Management)\tB-2M - Beta-2 microglobulin (Biologically Active Substance)\tGrade 1 Vertigo (Finding)\tEQ5D02 (Intellectual Product)", + "output": "Acid-base regulation: respiratory acidosis (Electrolyte and Acid-Base Management)" + }, + { + "input": "Definition: Class Ascomycetes described as a mitosporic fungal genus. Phialophora verrucosa is a cause of chromomycosis (CHROMOBLASTOMYCOSIS). Ophiobolus is the teleomorph of Phialophora.\nConcepts: Flour, Flaxseed (Dietary Supplements)\tPhialophora species (Form family Dematiaceae)\tCENTRIFUGATION (field separation method)\tSUBSTANCE ABUSE MENTAL HEALTH SERV ADMIN (United States Public Health Service)\tBcr-Abl (b2a2)-Derived Peptide Vaccine (Pharmacologic Substance)", + "output": "Phialophora species (Form family Dematiaceae)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in protein folding and glycosylation.\nConcepts: Recurrent T-Cell Prolymphocytic Leukemia (T-Cell Prolymphocytic Leukemia)\tChoriomeningitis lymphocytic (Disease or Syndrome)\tIdentification/Tracking/Security Systems, Asset (Identification/Tracking/Security Systems)\tUpper GI (Other x-ray of digestive system)\tUDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 2 (Gene or Genome)", + "output": "UDP-GLUCOSE:GLYCOPROTEIN GLUCOSYLTRANSFERASE 2 (Gene or Genome)" + }, + { + "input": "Definition: something described as this gene plays a role in B-cell regulation and intercellular interactions.\nConcepts: Reduced lactate dehydrogenase B level (Abnormal lactate dehydrogenase level)\tpositive regulation of toluene catabolism (positive regulation of toluene metabolic process)\tLung Inflammations (Pneumonia)\tflavin (Coenzymes)\tC-X-C motif chemokine ligand 13 (CXC Cytokine Gene)", + "output": "C-X-C motif chemokine ligand 13 (CXC Cytokine Gene)" + }, + { + "input": "Definition: something described as a protein complex of actin and MYOSINS occurring in muscle. It is the essential contractile substance of muscle.\nConcepts: coagulation factor XII (Gene or Genome)\tactomyosin (Muscle Proteins)\tnegative regulation of necroptosis (negative regulation of cellular process)\tSecretory adrenocortical adenoma (Neoplastic Process)\tRollinias (Annoneae)", + "output": "actomyosin (Muscle Proteins)" + }, + { + "input": "Definition: 2-oxoglutarate-dependent dioxygenase activity described as catalysis of the reaction: 2'-deoxyuridine + 2-oxoglutarate + O(2) = 2-deoxy-D-ribono-1,4-lactone + CO(2) + succinate + uracil.\nConcepts: PQL0103 (Intellectual Product)\tNight Sweating (Symptom severity level: perimenopause)\tHAMD1-Retardation (HAMD-17 Questionnaire Question)\tVQ - Ventilation perfusion scan (Radionuclide study of lung)\t2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2-oxoglutarate-dependent dioxygenase activity)", + "output": "2'-deoxyuridine,2-oxoglutarate:oxygen oxidoreductase (2-oxoglutarate-dependent dioxygenase activity)" + }, + { + "input": "Definition: iron transport described as a process in which an iron ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.\nConcepts: HER2Bi-armed activated T cells (Allogeneic Lymphocyte)\tInterleukin-18 Receptors (Receptor)\tiron ion membrane transport (iron transport)\tIsoprenylation Inhibition (Isoprenylation)\tCaretaking/parenting (PSYCHOSOCIAL DOMAIN)", + "output": "iron ion membrane transport (iron transport)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the estrone sulfate in a biological specimen.\nConcepts: Estrone Sulfate Measurement (17-Ketosteroids measurement)\tFocal cognitive seizure with dyslexia/alexia (Cognitive seizure)\tProstate Cancer Will Spread in One of Three Patients Within Ten Years Without Treatment (Clinical or Research Assessment Question)\tGrade 3 Stroke, CTCAE (Stroke, CTCAE)\tOrder Sordariales (Fungus)", + "output": "Estrone Sulfate Measurement (17-Ketosteroids measurement)" + }, + { + "input": "Definition: Tissue described as the deepest layer of the epidermis, which is adjacent to the dermis, and which is the primary location of mitotically active cells of the epidermis.\nConcepts: MKREFID (Reference ID)\tStratum basale of epidermis (Skin)\tM1 Adult Acute Myeloid Leukemia (Acute Myeloid Leukemia, M1)\tQLES131 (Intellectual Product)\tHemodialysis Chairs (Chairs)", + "output": "Stratum basale of epidermis (Skin)" + }, + { + "input": "Definition: Linear Analogue Self-Assessment described as a six-item, self-reported questionnaire designed to measure general well-being and the major domains of quality of life (mental, physical, emotional, social, and spiritual well-being) using a linear analogue scale to describe the assessment responses.\nConcepts: PARP inhibitor CEP-9722 (Pharmacologic Substance)\tDihydrocortisone (ADRENAL AND GONADAL HORMONES)\tLinear Analogue Self-Assessment-6 (Intellectual Product)\tphosphothreonine lyase activity (carbon-oxygen lyase activity, acting on phosphates)\tIL-5 receptor complex location (plasma membrane signaling receptor complex)", + "output": "Linear Analogue Self-Assessment-6 (Intellectual Product)" + }, + { + "input": "Definition: Physiology described as tendency of an organism to maintain a state of physiological equilibrium and the processes by which such a stable internal environment is maintained.\nConcepts: 2 OF 5 (Clinical or Research Assessment Answer)\treplication of plastid DNA (plastid DNA metabolic process)\thomeostasis- body function that maintain internal balance by adjusting its physiological processes. (Physiological Processes)\tAtypical dentin dysplasia due to SMOC2 deficiency (Autosomal recessive hereditary disorder)\tVitamin E Topical (Clinical Drug)", + "output": "homeostasis- body function that maintain internal balance by adjusting its physiological processes. (Physiological Processes)" + }, + { + "input": "Definition: something described as craniofacial anomalies, including those that involve the pinna, ear canal, ear tags, ear pits, and temporal bone anomalies.\nConcepts: Provision of bedtime routine (Therapeutic procedure)\tKiSS-1 metastasis-suppressor protein, human (KISS1 Gene Product)\tabnormalities craniofacial (Genetics/Birth Defects)\tV(V) (Element, Ion, or Isotope)\tTourniquets, Pneumatic (Tourniquets)", + "output": "abnormalities craniofacial (Genetics/Birth Defects)" + }, + { + "input": "Definition: Histone deacetylase inhibitor described as a broad-spectrum phenyl hydroxamic acid inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. In addition, this agent has been shown to inhibit homologous recombination (HR) activity by inhibiting the expression of RAD51. RAD51, a homologue of bacterial RecA, assists in the repair of DNA double-strand breaks (DSBs). Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68920\" active clinical trials using this agent.\nConcepts: STCG01-STC ARC Grade (ARC STC Grade Clinical Classification Question)\tPhenoxazole (Azoles)\tProtein, Ribosomal (Translation Process Protein)\tRatio AUC Infinity Obs (Area Under the Curve Ratio)\tABEXINOSTAT (Histone deacetylase inhibitor)", + "output": "ABEXINOSTAT (Histone deacetylase inhibitor)" + }, + { + "input": "Definition: Cell Function described as uptake of D-glucose into the blood by absorption from the small intestine.\nConcepts: intestinal D-glucose absorption (intestinal hexose absorption)\tFebrile convulsion NOS (Convulsions, not elsewhere classified)\tAttached earlobes (Abnormality of earlobe)\tAbnormality of urine catecholamine concentration (Abnormality of urine homeostasis)\tWolinella Tanner et al. 1981 (Epsilonproteobacteria)", + "output": "intestinal D-glucose absorption (intestinal hexose absorption)" + }, + { + "input": "Definition: Tissue described as a gelatinous type of connective tissue that is found in the umbilical cord.\nConcepts: TDG (DNA Repair Gene)\tMucous tissue (Loose connective tissue)\tVirus Structure (German translation of the Medical Subject Headings)\tsbsqnt30+min out-ofc Ayvdcm (Health Care Activity)\torganic acid binding (Molecular Function)", + "output": "Mucous tissue (Loose connective tissue)" + }, + { + "input": "Definition: Disease or Syndrome described as diseases that do not exhibit symptoms.\nConcepts: Conditions, Asymptomatic (Disease Attributes)\tCuphea (Lythraceae)\tAUDIOL (Paramedical Sciences)\tBreast Cancer Treatment Outcomes Scale (BCTOS) - Cosmetic Status (Intellectual Product)\tphenylenediamines (Pharmacologic Substance)", + "output": "Conditions, Asymptomatic (Disease Attributes)" + }, + { + "input": "Definition: Finding described as extent of healing of a burn site\nConcepts: Envir (Environment or geographical location)\tretinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning (retinoic acid receptor signaling pathway)\t8 (Body Location or Region)\tBurn Healing (Actual Effective Body Tissue Integrity)\tTRIFUNCTIONAL PROTEIN DEFICIENCY (Lipid Metabolism Disorders)", + "output": "Burn Healing (Actual Effective Body Tissue Integrity)" + }, + { + "input": "Definition: something described as a rare movement disorder developed during PREGNANCY, characterized by involuntary jerky motion (CHOREA) and inability to maintain stable position of body parts (ATHETOSIS). RHEUMATIC FEVER and collagen vascular disorders are frequently associated with this disease. Chorea may vary from mild to severe and occurs in approximately 1 per 2,000 to 3,000 pregnancies. (From Md Med J 1997 Sep;46(8):436-9)\nConcepts: Ddb1-Ckn1 complex (nucleotide-excision repair complex location)\tPregnancy-Induced Chorea (Complication occurring during pregnancy)\tIs Another NRAS Mutation Present (Presence of Another Mutation)\toncolytic measles virus encoding thyroidal sodium iodide symporter (Oncolytic Viruses)\tPP2A Subunit B Isoform Alpha (Amino Acid, Peptide, or Protein)", + "output": "Pregnancy-Induced Chorea (Complication occurring during pregnancy)" + }, + { + "input": "Definition: Molecular Function described as combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity.\nConcepts: Peroneal veins (Posterior tibial vein and its tributaries)\tDecreased activity of mitochondrial complex II (Finding)\tregulation of isotype switch recombination to IgE isotypes (Genetic Function)\tAnosmia eunuchoidism (Endocrine Syndrome)\tneurotransmitter receptor activity (Molecular Function)", + "output": "neurotransmitter receptor activity (Molecular Function)" + }, + { + "input": "Definition: cellulose biosynthetic process described as the chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria.\nConcepts: SF-36 v2.0 Standard - Question 11c (Intellectual Product)\tATLAS Score Clinical Classification (Clinical Classification)\tWalking 30 yards (Intellectual Product)\tIleum fistula (Gastrointestinal Fistula, CTCAE 3.0)\tbacterial cellulose biosynthesis (Molecular Function)", + "output": "bacterial cellulose biosynthesis (Molecular Function)" + }, + { + "input": "Definition: something described as the process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Hepatitis A, Antibody (Medical Device)\tintolerance exercise (pulmonary stress testing six-minute walk test)\tStyrax L., 1753 (Plant)\tglossopharyngeal nerve formation (cranial nerve formation)\tFSFI (Intellectual Product)", + "output": "glossopharyngeal nerve formation (cranial nerve formation)" + }, + { + "input": "Definition: Cell Function described as the directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions.\nConcepts: Bad memory (Impaired cognition)\tSCOTOMATA (Disorder of refraction AND/OR accommodation)\tsubstrate-bound cell migration, adhesion receptor recycling (Cell Function)\tGenus Caulobacter (Bacterium)\tnegative regulation of apoptotic signaling pathway (negative regulation of signal transduction)", + "output": "substrate-bound cell migration, adhesion receptor recycling (Cell Function)" + }, + { + "input": "Definition: something described as national Comprehensive Cancer Network/Functional Assessment of Cancer Therapy-Bladder Symptom Index-18 Version 2 - I have nausea.\nConcepts: H1 Histone Family, Member 1 Gene (Gene or Genome)\tbismuthum/bismuth sub-nitrat (Homeopathic remedies letter B)\tFAC02812 (Intellectual Product)\tLEC01-Sudden Violent Death: Learned (LEC-5 Standard Version Questionnaire Question)\tFAC02806 (NCCN-FACT FBLSI-18 Version 2 Questionnaire Question)", + "output": "FAC02812 (Intellectual Product)" + }, + { + "input": "Definition: Female genital implant described as a fallopian tube prosthesis is a device designed to maintain the patency (openness) of the fallopian tube and is used after reconstructive surgery.\nConcepts: Prostheses, Fallopian Tube (Prosthesis)\tPuerto Rican infant hypotonia syndrome (Hereditary Connective Tissue Disorder)\tAdenosine, 2',3'-dideoxy- (Pharmacologic Substance)\tEDUC PERSONNEL (Workers)\tArginine Test (SPECIFIC SUBSTANCE CHEMISTRY TESTS)", + "output": "Prostheses, Fallopian Tube (Prosthesis)" + }, + { + "input": "Definition: Medical Device described as a cardiopulmonary bypass intracardiac suction control is a device which provides the vacuum and control for a cardiotomy return sucker.\nConcepts: Sputum Cytology (Cytodiagnosis)\tSUCTION CONTROL, INTRACARDIAC, CARDIOPULMONARY BYPASS (Medical Device)\tDART Nausea Score 8 (Nausea Visual Analogue Scale)\tpositive regulation of positive chemotaxis to cAMP (regulation of positive chemotaxis to cAMP)\trenal sinus (Anatomical compartment space)", + "output": "SUCTION CONTROL, INTRACARDIAC, CARDIOPULMONARY BYPASS (Medical Device)" + }, + { + "input": "Definition: response to cytokine described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.\nConcepts: Transient decreased circulating total IgG (Decreased circulating total IgG)\tFACT-Taxane Version 4 - I Feel Nervous (FACT-Taxane Version 4 Questionnaire Question)\tresponse to granulocyte macrophage colony-stimulating factor (Cell Function)\tnuclear pre-replicative complex assembly involved in meiotic cell cycle (pre-replicative complex assembly involved in nuclear cell cycle DNA replication)\texternal hordeolum (Inflammatory disorder of head)", + "output": "response to granulocyte macrophage colony-stimulating factor (Cell Function)" + }, + { + "input": "Definition: Examination of reflexes described as complex involuntary response to an unexpected strong stimulus usually auditory in nature.\nConcepts: Anti-CEA/Anti-HSG Bispecific Monoclonal Antibody TF2 (Monoclonal Antibodies)\tPROSTHESIS, FALLOPIAN TUBE (Prosthesis)\tMUSCULAR DYSTROPHY, DISTAL, LATE-ONSET, AUTOSOMAL RECESSIVE (Disease or Syndrome)\tStartle Reaction (Organism Function)\tresponse to gravity (Cell Function)", + "output": "Startle Reaction (Organism Function)" + }, + { + "input": "Definition: HEMATOPOIETIC SYSTEM: GENERAL TERMS described as a hematopoietic process that refers to the production of erythrocytes.\nConcepts: hepatoblast differentiation (Stem Cell Differentiation)\tphosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity (phosphotransferase activity, for other substituted phosphate groups)\tErythropoiesis, NOS (Myelopoiesis)\tLeukaemia plasmacytic (Multiple Myeloma)\tcation:acetate symporter activity (solute:cation symporter activity)", + "output": "Erythropoiesis, NOS (Myelopoiesis)" + }, + { + "input": "Definition: something described as a chemoimmunotherapy regimen consisting of capecitabine and bevacizumab that is used for the treatment of colon cancer.\nConcepts: Structure of endocardium of right ventricle (Endocardium)\tdisease coxsackie (Enterovirus Infections)\tmolecular/cellular imaging (Diagnostic Procedure)\tCapecitabine-Bevacizumab (Regimen Used to Treat Colorectal Carcinoma)\tBiologicEntityPart.anatomicSiteLateralityCode (Anatomic Site Laterality Code)", + "output": "Capecitabine-Bevacizumab (Regimen Used to Treat Colorectal Carcinoma)" + }, + { + "input": "Definition: orbit described as abnormal recession of the eyeball within the eye socket.\nConcepts: Anti-Siglec-15 Monoclonal Antibody NC318 (Immunologic Factor)\tN-acyl-D-mannosamine dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tup-regulation of hair follicle maturation (regulation of hair follicle maturation)\tData Interface Systems (Information/Telecommunications Systems)\tEnophthalmos, NOS (Displacement of eye)", + "output": "Enophthalmos, NOS (Displacement of eye)" + }, + { + "input": "Definition: detection of external stimulus described as the series of events in which a gravitational stimulus is received and converted into a molecular signal.\nConcepts: noninvasive (Qualitative Concept)\tperception of gravity (detection of external stimulus)\tIB (Body Part, Organ, or Organ Component)\tMalignant Potential (Qualitative Concept)\tcarbohydrate kinase activity (kinase activity)", + "output": "perception of gravity (detection of external stimulus)" + }, + { + "input": "Definition: Inorganic Chemical described as a whitish, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Cadmium chloride is used in electroplating, printing, photocopying, dyeing, mirrors, vacuum tubes, lubricants, analytical chemistry and as a chemical intermediate to produce cadmium containing pigments and stabilizers. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Cadmium chloride is a known carcinogen and is associated with an elevated risk of developing lung cancer.\nConcepts: Dichloride, Cadmium (Metallic compound patch test product)\tspindle biosynthesis (spindle organization)\tHPIV1AG (Microbiology procedure)\tMVA-MUC1-IL2 vaccine (Vaccinia Vaccine)\ttachypnoea (Lung)", + "output": "Dichloride, Cadmium (Metallic compound patch test product)" + }, + { + "input": "Definition: SEM1 gene described as human SEM1 wild-type allele is located in the vicinity of 7q21.3 and is approximately 228 kb in length. This allele, which encodes 26 proteasome complex subunit SEM1 protein, is involved in the mediation of protein degradation. The gene may play a role in split hand/split foot malformation.\nConcepts: Telomere (Chromosomes)\tAplasia of patella (Absence of lower limb)\tChromosome 14 Proximal Arm (Arm of chromosome)\tChromosome 7 Open Reading Frame 76 Gene (Gene or Genome)\tThoracic NUT Carcinoma (Neoplastic Process)", + "output": "Chromosome 7 Open Reading Frame 76 Gene (Gene or Genome)" + }, + { + "input": "Definition: something described as determination of the presence of an infectious disease(s) or condition or the distinguishing of one disease or condition from another.\nConcepts: FAMS01-My Family Has Accepted My Illness (FAMS Questionnaire Question)\tcommunicable disease diagnosis (Diagnostic Procedure)\tAdHer2/DC (Immunologic Factor)\ttrans spliceosomal complex location (Cell Component)\t3: 133518957-133560302 (Chromosome 3 Physical Location)", + "output": "communicable disease diagnosis (Diagnostic Procedure)" + }, + { + "input": "Definition: Streptomyces described as an actinomycete best known as the producer of the commercially important antibiotic OXYTETRACYCLINE.\nConcepts: Soluble Tumor Necrosis Factor Receptor (Protein or Enzyme Type Measurement)\tStreptomyces rimosus Sobin et al. 1953 (Bacterium)\tformation by symbiont of arbuscule for nutrient acquisition from host (formation of specialized structure for nutrient acquisition from host)\tventral aorta morphogenesis (aorta morphogenesis)\tTwenty Pack (Quantitative Concept)", + "output": "Streptomyces rimosus Sobin et al. 1953 (Bacterium)" + }, + { + "input": "Definition: Xanthomatosis described as the presence of multiple xanthomas (xanthomata) in the skin distributed in the creases of the palm of the hand. Xanthomas are yellowish, firm, lipid-laden nodules in the skin. []\nConcepts: superior olivary nucleus maturation (anatomical structure maturation)\tA27 CORPUS CALLOSUM (CEREBRAL HEMISPHERES, CORPUS CALLOSUM AND RHINENCEPHALON)\tXanthoma palmare striatum (Finding)\tdiadenosyl hexaphosphate metabolic process (diadenosine polyphosphate metabolic process)\tAxonal Fasciculation (neuron recognition)", + "output": "Xanthoma palmare striatum (Finding)" + }, + { + "input": "Definition: something described as any endocannabinoid signaling pathway that is involved in trans-synaptic signaling by endocannabinoid.\nConcepts: Pancreatic Intraductal Papillary-Mucinous Tumor (cellular diagnosis, pancreatic cancer)\tPFRK Gene Mutation (Cell or Molecular Dysfunction)\tStammering (Special Education)\tinitiation of acetate breakdown by acetate (Cell Function)\tendocannabinoid signaling pathway involved in trans-synaptic signaling (endocannabinoid signaling pathway)", + "output": "endocannabinoid signaling pathway involved in trans-synaptic signaling (endocannabinoid signaling pathway)" + }, + { + "input": "Definition: Research Techniques described as the use of controlled observations and measurements to test hypotheses.\nConcepts: autologous AML-specific CTL (therapeutic autologous lymphocytes)\tchlorexolone (Pharmacologic Substance)\t2-hydroxyisoflavanone synthase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tEEG with centrotemporal focal spike waves (Finding)\tExperimental Method (Research Techniques)", + "output": "Experimental Method (Research Techniques)" + }, + { + "input": "Definition: something described as multipotent stem cells of mesenchymal origin isolated from umbilical cord blood. Umbilical cord blood-derived mesenchymal stem cells can differentiate into a variety of cell types including fibroblasts, osteoblasts, chondrocytes, myocytes, adipocytes, and endothelial cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82688\" active clinical trials using this agent.\nConcepts: umbilical cord blood-derived MSCs (Non-Tumor Cell Derivative Vaccine)\tCDISC ADAS-Cog - Word Recognition: Word 5 (ADAS-Cog CDISC Version Questionnaire Question)\tdefence response to pathogenic bacteria, incompatible interaction (defense response to bacterium)\tMediastinal Cancer (Intellectual Product)\tvenous (Anatomy Qualifier)", + "output": "umbilical cord blood-derived MSCs (Non-Tumor Cell Derivative Vaccine)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of transdifferentiation.\nConcepts: Family (Biological Taxon)\tRECEPT EPOPROSTENOL (Receptor)\tWD6-Concentrating for Ten Minutes (Intellectual Product)\tAdnexa (Body Part, Organ, or Organ Component)\tregulation of transdifferentiation (Cell Function)", + "output": "regulation of transdifferentiation (Cell Function)" + }, + { + "input": "Definition: Assessment scales described as a set of criteria used to determine the activity of vasculitis.\nConcepts: Tetralogy of Fallot with pulmonary atresia and major aortopulmonary collateral arteries (Congenital Abnormality)\tMH (Ethnic group)\tBVAS - Birmingham Vasculitis Activity Score (Research or Clinical Assessment Tool)\tCorneal intraepithelial dyskeratosis, palmoplantar hyperkeratosis, laryngeal dyskeratosis syndrome (Inherited disorder of keratinization)\tFatigable weakness of chewing muscles (Fatigable weakness of bulbar muscles)", + "output": "BVAS - Birmingham Vasculitis Activity Score (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: something described as human EBF1 wild-type allele is located in the vicinity of 5q34 and is approximately 401 kb in length. This allele, which encodes transcription factor COE1 protein, is involved in the modulation of transcription. Genetic variation may be associated with both the occurrence and relapse of acute lymphoblastic leukemia.\nConcepts: OLF1 (Gene or Genome)\tTestosterone enanthate product (Testosterone and testosterone derivative)\t(-)-reserpine (Alkaloids)\t\"Respiratory, Developmental, Rehabilitative and Restorative Service Providers\"; \"Respiratory Therapist, Registered\", Pulmonary Function Technologist (Professional or Occupational Group)\tPhagosomes (Early endosome)", + "output": "OLF1 (Gene or Genome)" + }, + { + "input": "Definition: Gene or Genome described as human SMIM24 wild-type allele is located in the vicinity of 19p13.3 and is approximately 7 kb in length. This allele, which encodes small integral membrane protein 24, has no known function.\nConcepts: tRNA, Glycine-Specific (RNA, Transfer, Amino Acid-Specific)\tStage IVB Nasopharynx Keratinizing Epidermoid Carcinoma (Neoplastic Process)\tVoltage-Gated Sodium Channel beta-4 Subunit (Biologically Active Substance)\tSmall Integral Membrane Protein 24 wt Allele (Gene or Genome)\tPL Extract (Pharmacologic Substance)", + "output": "Small Integral Membrane Protein 24 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual has or had trouble controlling their blood sugar.\nConcepts: Have you had trouble controlling your blood sugars (Clinical or Research Assessment Question)\tgrowth cone (site of polarized growth)\tdynein arm assembly (Molecular Function)\tstools (Body Substance)\tSEND-COUNTRY (Intellectual Product)", + "output": "Have you had trouble controlling your blood sugars (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving octopine, (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine.\nConcepts: chronic phase CGL (Chronic leukemia)\toctopine metabolism (dicarboxylic acid metabolic process)\tReferenceToStudyResults.publicationName (Publication Name)\tDental Prostheses Pontics (Dentures and Denture Products)\tpharmaceutical economics (Medical Economics)", + "output": "octopine metabolism (dicarboxylic acid metabolic process)" + }, + { + "input": "Definition: Protein Metabolism Process described as the chemical reactions and pathways resulting in the formation of TRAIL-R2 (TNF-related apoptosis inducing ligand receptor 2), which engages a caspase-dependent apoptotic pathway and mediates apoptosis via the intracellular adaptor molecule FADD/MORT1.\nConcepts: Mediastinal Mixed Non-Seminomatous Germ Cell Tumor (Malignant Mixed Tumor)\tHistone Cluster 2, H3c Pseudogene Gene (Gene or Genome)\ttumor necrosis factor receptor superfamily member 10B biosynthetic process (TRAIL receptor biosynthetic process)\tVasculitides (Disease or Syndrome)\trevisionReasonCode (Reason Code)", + "output": "tumor necrosis factor receptor superfamily member 10B biosynthetic process (TRAIL receptor biosynthetic process)" + }, + { + "input": "Definition: ADCS-ADL Questionnaire Question described as alzheimer's Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) Which pastimes did he/she perform: sewing.\nConcepts: ADL01-Pastime: Sewing (ADCS-ADL Questionnaire Question)\tTotal Clearance Observed for Unbound Drug (Total Clearance Observed)\tBlocker, Potassium Channel (Central Nervous System Agents)\tdetection of dietary excess (nervous system process)\tMulti-subtype Natural Human Leukocyte Interferon Alpha (Pharmacologic Substance)", + "output": "ADL01-Pastime: Sewing (ADCS-ADL Questionnaire Question)" + }, + { + "input": "Definition: Artificial Intelligence described as a computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.\nConcepts: mg/mL/(mg/m2/day) (Measurement Unit Description)\tnetworks neural (Computer Applications)\tDriving Units, Gantry/Table (Medical Device)\tcooling (Temperature change)\tpp125FAK (Amino Acid, Peptide, or Protein)", + "output": "networks neural (Computer Applications)" + }, + { + "input": "Definition: something described as ying su ke\nConcepts: 13: 27967232-27773790 (Chromosome 13 Physical Location)\tPapaveris / ying su ke (Oriental herbs and natural substances letter P)\tCRQ-SAS Follow-Up Administration Version - Participate in Social Activities (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\tglomerular parietal epithelial cell differentiation (Cell Function)\tUnit device (Medical Device)", + "output": "Papaveris / ying su ke (Oriental herbs and natural substances letter P)" + }, + { + "input": "Definition: Abnormal breathing described as any anomaly measure by pulmonary function testing, which includes spirometry, measures of diffusing capacity, and plethysmography.\nConcepts: Lung function testing abnormal (Lung function testing abnormal)\tug/ml/(kg/m2) (Unit of concentration)\tAdenoviruses, Human (Adenoviruses)\tCDISC SDTM Observational Study Sampling Method Terminology (CDISC SDTM Terminology)\tPlatelet-Derived Growth Factor Receptor Beta Homodimeric Complex (Amino Acid, Peptide, or Protein)", + "output": "Lung function testing abnormal (Lung function testing abnormal)" + }, + { + "input": "Definition: something described as an intratumor route that begins within a tumor cavity.\nConcepts: IPI Risk Group (Research or Clinical Assessment Tool)\tRefractory Biliary Tract Carcinoma (Refractory Digestive System Carcinoma)\tFT-PUL 2.0 TESTCD (CDISC Functional Test Terminology)\tmethylthiopropylmalate dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tTumour cavity (Intracavernous Route of Drug Administration)", + "output": "Tumour cavity (Intracavernous Route of Drug Administration)" + }, + { + "input": "Definition: Immunoconjugates described as a soluble fusion protein composed of the extracellular domain of the activin receptor type IIA (ActRIIA) linked to the Fc portion of human IgG1 with anabolic bone activity. Sotatercept selectively binds to activin, inhibiting its binding to ActRIIA and ActRIIA signaling, resulting in the stimulation of osteoblast activity and the inhibition of osteoclast activity and so normal bone formation and increased bone mineral density and strength. The Fc moiety of this fusion protein binds to the salvage receptor FcRN, preventing its lysosomal degradation and so extending its half-life in the circulatory system. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C80038\" active clinical trials using this agent.\nConcepts: Carcinoma of the External Ear (Ear carcinoma)\tup-regulation of homofermentation (positive regulation of catabolic process)\tAbsent end part of the outermost bone of the index finger (Absent epiphyses of the 2nd finger)\tsotatercept (Pharmacologic Substance)\toxalate transmembrane transporter activity (dicarboxylic acid transmembrane transporter activity)", + "output": "sotatercept (Pharmacologic Substance)" + }, + { + "input": "Definition: Q-LES-Q Questionnaire Question described as quality Of Life Enjoyment And Satisfaction Questionnaire (Q-LES-Q) How often did you enjoy the leisure activities?\nConcepts: regulation of inhibitory postsynaptic potential (regulation of membrane potential)\tZNF40A (Gene or Genome)\tQLES165 (Q-LES-Q Questionnaire Question)\tEncapsulated Variant Thyroid Gland Papillary Carcinoma (Tumor contained within organ capsule)\tSachet Dosing Unit (Unit dose)", + "output": "QLES165 (Q-LES-Q Questionnaire Question)" + }, + { + "input": "Definition: Poisoning described as disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails.\nConcepts: Arsenical Neurotoxicity Syndrome (Toxic effect of chiefly nonmedicinal substance)\tHAMD2-Depersonalization/Derealization (HAMD 21 Questionnaire Question)\tRisk Control: Infectious Process (Risk control behavior)\tLEPRECHAUNISM (Disease or Syndrome)\tabattoir (Manufacturing and Industrial Facilities)", + "output": "Arsenical Neurotoxicity Syndrome (Toxic effect of chiefly nonmedicinal substance)" + }, + { + "input": "Definition: Protein Tyrosine Kinase described as a protein encoded by the ALK gene.\nConcepts: diverticula (Mechanical abnormality)\tALK Gene Product (Protein Tyrosine Kinase)\tColostomy Procedure (Repair of large intestine)\tClinical modifier (All)\tOSTEOSARCOMA, LIMB ANOMALIES, AND ERYTHROID MACROCYTOSIS WITH MEGALOBLASTIC MARROW (Multiple malformation syndrome with limb defect as major feature)", + "output": "ALK Gene Product (Protein Tyrosine Kinase)" + }, + { + "input": "Definition: Hematoma described as a subperiosteal hemorrhage limited to the surface of one cranial bone. It is seen in the newborn and often related to the birthing process.\nConcepts: Metastatic Cervical Adenocarcinoma (Metastatic Cervical Carcinoma)\tAnn Arbor Stage II Mixed Cellularity Classic Hodgkin Lymphoma (Stage II Hodgkin Lymphoma)\tForced Expiratory Volume 1 Test (Diagnostic Procedure)\tCephalohematoma (Perinatal hemorrhage)\tprotein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity (Molecular Function)", + "output": "Cephalohematoma (Perinatal hemorrhage)" + }, + { + "input": "Definition: Diagnostic Procedure described as visual display of structural or functional patterns of the lungs or lung tissues for diagnostic evaluation or imaging of anatomical structures; includes measuring physiologic and metabolic responses to physical and chemical stimuli.\nConcepts: Pancreatic Small Cell Carcinoma (Neoplastic Process)\tlung imaging/visualization/scanning (Diagnostic Procedure)\tGrade 4 Neonatal Respiratory Distress Syndrome (Finding)\tFor-Profit Insurance Plans (Health Insurance)\tCredential letter (Document type)", + "output": "lung imaging/visualization/scanning (Diagnostic Procedure)" + }, + { + "input": "Definition: something described as round cell liposarcoma that does not respond to treatment.\nConcepts: Moist Desquamation (Sign or Symptom)\tphosphonate dehydrogenase activity (Molecular Function)\tSMOKE STICK (Biomedical or Dental Material)\tHour Times Nanomole per Liter per Meter Squared (Measurement Unit Description)\tRefractory Round Cell Liposarcoma (Neoplastic Process)", + "output": "Refractory Round Cell Liposarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Organic Chemical described as an orally active inhibitor of coagulation factor Xa (activated factor X) with anticoagulant activity. Otamixaban has a short half-life of 1.5 to 3 hours.\nConcepts: Thermotoga maritima (Gram-Negative Anaerobic Straight, Curved, and Helical Rods)\totamixaban (Anticoagulants)\tpancreatic alpha cell development (Cell Function)\tnucleate red blood cell maturation (Cell Function)\tendospore formation (asexual sporulation resulting in formation of a cellular spore)", + "output": "otamixaban (Anticoagulants)" + }, + { + "input": "Definition: Conceptual Entity described as specifies whether any pregnancies resulted in miscarriages.\nConcepts: MSCRGIND (Indicator)\tStructure of sternohyoid muscle (Muscle)\tIntracarotid (Anatomy Qualifier)\tAbdominal Surgery Patient (Surgery Patient)\tChloroplast RNA (RNA)", + "output": "MSCRGIND (Indicator)" + }, + { + "input": "Definition: Cellular Structures described as biological membranes; do not confuse with ARTIFICIAL MEMBRANE.\nConcepts: Ganglion Cells (Ganglion cell)\tplastid mRNA editing complex (mRNA editing complex)\tmembrane (Cellular Structures)\tBACTEROIDES FAECIS (Bacteroides)\tBone Retractors (Medical Device)", + "output": "membrane (Cellular Structures)" + }, + { + "input": "Definition: Urolithiasis described as the presence of a calculus in the ureter of the kidney; this is most often composed of mineral salts and proteins.\nConcepts: gp209-2M Antigen (Vaccine Antigen)\tO-succinyltransferase activity (O-acyltransferase activity)\tstone ureter (Calculus of upper urinary tract)\tMOAB D6.12 (Monoclonal Antibodies)\tHIV-1 p24 Antigen (Human immunodeficiency virus test)", + "output": "stone ureter (Calculus of upper urinary tract)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the kind of result value.\nConcepts: ascospore wall chitin metabolic process (fungal-type cell wall polysaccharide metabolic process)\tValue Type Code (Type Code)\tPITUITARY FORKHEAD FACTOR, MOUSE, HOMOLOG OF (Gene or Genome)\tCarbohydrate (Chondroitin 6) Sulfotransferase 3 wt Allele (CHST3 gene)\tfemale gametophyte central cell differentiation (Cell Differentiation process)", + "output": "Value Type Code (Type Code)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier.\nConcepts: Wrist-Hand-Finger Orthoses (Orthoses, Upper Limb)\tAtg8-specific protease activity (ubiquitin-like protein-specific protease activity)\tUNIV MED CENTER (Health care facility)\tBIIB022 (Monoclonal Antibodies)\tCD80 Breast Cancer Vaccine (Allogeneic Tumor Cell Vaccine)", + "output": "Atg8-specific protease activity (ubiquitin-like protein-specific protease activity)" + }, + { + "input": "Definition: regulation of behavior described as any process that modulates the frequency, rate or extent of foraging behavior.\nConcepts: phosphatidate binding (Phospholipid Binding)\tMOLAR ROOTS, PYRAMIDAL, WITH JUVENILE GLAUCOMA AND UNUSUAL UPPER LIP (Congenital anomaly of tooth)\tE3 Ubiquitin Protein Ligase, HECT Domain Containing, 1 Gene (UBR5 gene)\thh signaling pathway involved in spinal cord motor neuron cell fate specification (Molecular Function)\tregulation of foraging behavior (Individual Behavior)", + "output": "regulation of foraging behavior (Individual Behavior)" + }, + { + "input": "Definition: Cell Component described as actin-based structures involved in establishing close contact between mature spermatids and Sertoli cells at the luminal end of the Sertoli cell.\nConcepts: apical tubulobulbar complex location (tubulobulbar complex)\tAlert Verbal Painful Unresponsive Scale Clinical Classification Test Code (Intellectual Product)\t3-carboxy-2-quinoxalinylpenicillanic acid (penicillins)\tSpouse (Immediate family member)\tTympanic thermometer (Medical Device)", + "output": "apical tubulobulbar complex location (tubulobulbar complex)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as an ethosuximide test system is a device intended to measure ethosuximide, an antiepileptic drug, in human specimens. Measurements obtained by this device are used in the diagnosis and treatment of ethosuximide overdose and in monitoring levels of ethosuximide to ensure appropriate therapy.\nConcepts: Digital Radiography Detectors (Medical Device)\tactivation of tyrosine hydroxylase activity (regulation of tyrosine 3-monooxygenase activity)\tRADIOIMMUNOASSAY, ETHOSUXIMIDE (Indicator, Reagent, or Diagnostic Aid)\tcasbene synthetase activity (Molecular Function)\t1-(2-Amino-2-oxoethyl)-1,4-dihydropyridine-3-carboxamide (Pharmaceutical Adjuvants)", + "output": "RADIOIMMUNOASSAY, ETHOSUXIMIDE (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Chemistry, Pharmaceutical described as the entire process of bringing a new drug to the market. It includes both preclinical and clinical testing, and regulatory approval.\nConcepts: ADCRGW23 (Intellectual Product)\tDevelopment, Pharmaceutical (Biomedical Occupation or Discipline)\tCFHL (Gene or Genome)\tProstate Capsule (Prostate and seminal vesicle)\tPaced Tapping Functional Test Question (Intellectual Product)", + "output": "Development, Pharmaceutical (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Cell Component described as a complex of collagen trimers such as a fibril or collagen network.\nConcepts: Grade 3 Movements Involuntary, CTCAE (Movements Involuntary, CTCAE)\tACID, VANILMANDELIC, ELECTROPHORETIC SEPARATION (Medical Device)\tcomplex location of collagen trimers (supramolecular complex)\tRAB12 (Gene or Genome)\tConjunctival Melanoma pT1 TNM Finding v8 (Conjunctival Melanoma Pathologic Primary Tumor TNM Finding v8)", + "output": "complex location of collagen trimers (supramolecular complex)" + }, + { + "input": "Definition: Adrenal Cortex Diseases described as an autosomal dominant syndrome caused by dysregulation of the amiloride-sensitive sodium channel, which is characterized by early onset hypertension, hypokalemia, metabolic alkalosis, low plasma renin, and hypoaldosteronism.\nConcepts: Duplication of the renal pelvis (Accessory kidney)\tExocrine system (Set of heterogeneous anatomical structures)\tUnresectable Malignant Mesothelioma (Unresectable Malignant Neoplasm)\tPseudoprimary aldosteronism (Hereditary disorder of endocrine system)\tRetention Balloon Catheters (Medical Device)", + "output": "Pseudoprimary aldosteronism (Hereditary disorder of endocrine system)" + }, + { + "input": "Definition: Disease or Syndrome described as a non-neoplastic disorder that affects the fallopian tube. Representative examples include acute and chronic salpingitis, salpingitis isthmica nodosa, and endometriosis.\nConcepts: PODCI280 (Intellectual Product)\tColony counter, manual (Devices)\tup regulation of sensory perception of sweet taste (positive regulation of nervous system process)\tNon-Prostatic Acid Phosphatase (Laboratory Procedure)\tFallopian Tube Non-Neoplastic Disorder (Disease or Syndrome)", + "output": "Fallopian Tube Non-Neoplastic Disorder (Disease or Syndrome)" + }, + { + "input": "Definition: Tubule of testis described as zone of testis located at the superior end. Examples: There is only one upper pole of testis.\nConcepts: HALLUCINATIONS (PERCEPTION AND PERCEPTION DISTURBANCES)\tsynthesis of RNA primer involved in bacterial-type DNA replication (Genetic Function)\tPolus superior (Pole)\tDNA-REAGENTS, LEGIONELLA (Indicator, Reagent, or Diagnostic Aid)\tlung papilloma (Disease due to Papilloma virus)", + "output": "Polus superior (Pole)" + }, + { + "input": "Definition: Industrial Aid described as a strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.\nConcepts: Sensory Rhodopsin (Biologically Active Substance)\tInterference with Family Life due to Physical Condition or Medical Treatment (Findings-Based Question)\tOxalic acid (Organic Chemical)\tNephrotic syn, prolifer (Disease or Syndrome)\tPotassium Large Conductance Calcium-Activated Channel, Subfamily M, Alpha Member 1 Gene (Ion Channel Protein Gene)", + "output": "Oxalic acid (Organic Chemical)" + }, + { + "input": "Definition: Chemical categorised functionally described as a xanthine oxidase inhibitor.\nConcepts: Episiotomies (Operation to facilitate delivery)\tBngn occ ep of chdhd-early ons (Benign Occipital Epilepsy)\tOxoallopurinol (Pyrazoles)\tSupervisors of Installation, Maintenance, and Repair Workers (Miscellaneous Occupation)\tVasa deferentia (Set of organ regions)", + "output": "Oxoallopurinol (Pyrazoles)" + }, + { + "input": "Definition: Cell Function described as any process that stops, prevents or reduces the frequency, rate or extent of histamine secretion by mast cell.\nConcepts: negative regulation of histamine secretion by mast cell (Cell Function)\tType of Stem Cell Transplant Conditioning (Intellectual Product)\tGastric Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v8 (Finding)\tproteolysis (Protein Degradation, Regulatory)\tReservation (Geographic Locations)", + "output": "negative regulation of histamine secretion by mast cell (Cell Function)" + }, + { + "input": "Definition: CDISC Questionnaire Terminology described as test codes of questionnaire questions associated with the Roland Morris disability questionnaire for the Clinical Data Interchange Standards Consortium (CDISC) Standard Data Tabulation Model (SDTM).\nConcepts: 6p22.2-p21.3 (Chromosome band)\tRoland Morris Disability Questionnaire Questionnaire Test Code (Intellectual Product)\tacetoacetyl-CoA hydrolase activity (CoA hydrolase activity)\tGLRX5 (glutaredoxin 5) related sideroblastic anemia (Autosomal recessive hereditary disorder)\tbenzothiazole-2-sulfonate hydrolase activity (hydrolase activity, acting on carbon-sulfur bonds)", + "output": "Roland Morris Disability Questionnaire Questionnaire Test Code (Intellectual Product)" + }, + { + "input": "Definition: Congenital hypoplasia of cerebrum described as a rare non-syndromic cerebellar malformation with characteristics of loss of volume in the right or left cerebellar hemisphere, with intact vermis and no other neurological anomalies (normal cerebral hemispheres, fourth ventricle, pons, medulla and midbrain). Patients may be asymptomatic or may present developmental and speech delay, hypotonia, abnormal ocular movements, persistent headaches and/or peripheral vertigo and ataxia. Neurological examination is otherwise normal.\nConcepts: Pipette (Device Component or Accessory)\tIsolated unilateral hemispheric cerebellar hypoplasia (Congenital hypoplasia of cerebrum)\tN2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)\t5Alpha Reductase, Steroid (Steroid metabolism disorder marker)\tSuture Dose Form (Solid Dose Form)", + "output": "Isolated unilateral hemispheric cerebellar hypoplasia (Congenital hypoplasia of cerebrum)" + }, + { + "input": "Definition: something described as an activity that is successfully or unsuccessfully completed. EXAMPLE(S): CBC performed on a specific StudySubject on a given day. A scheduled blood draw that is missed by a specific ExperimentalUnit on a given day. Generating an Anatomic Pathology Structured Report Taking a history and physical Performing surgery Doing a biopsy Diagnosing a disease Administering a drug Making an entry in a patient diary OTHER NAME(S): NOTE(S):\nConcepts: CS-1000 (Indicator, Reagent, or Diagnostic Aid)\tPhosphofructokinase Deficiencies, Muscle (Congenital anomaly of the hematopoietic system)\tperformed activity (Research Activity)\tOropharyngeal (p16-Negative) Carcinoma pM1 TNM Finding v8 (Oropharyngeal (p16-Negative) Cancer Pathologic Distant Metastasis TNM Finding v8)\tC-SSRS Baseline - Number of Actual Suicide Attempts (C-SSRS Baseline Questionnaire Question)", + "output": "performed activity (Research Activity)" + }, + { + "input": "Definition: cholic acid described as a bile salt formed in the liver by conjugation of deoxycholate with glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as a cholagogue and choleretic.\nConcepts: Evaluated Activity Relationship Probability (Quantitative Concept)\tmicrotubule polymerization (Microtubule alteration)\tBlasts 50 Percent or Less of Bone Marrow Nucleated Cells (Finding)\tGlycodeoxycholic Acid (Pharmacologic Substance)\tTriploid Syndrome (Polyploidy)", + "output": "Glycodeoxycholic Acid (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a person having origins in any of the original peoples of the Maldives.\nConcepts: MALDIVIAN (Asians)\tSpecify Other Spinal/Epidural Anesthesia Agents Administered (Intellectual Product)\tASCVD1TN (CDISC Clinical Classification Terminology)\tcomplement binding (Protein Binding)\tThymus Gland Hyperplasias (Abnormality of the thymus)", + "output": "MALDIVIAN (Asians)" + }, + { + "input": "Definition: Diagnostic Reagent described as the hydrochloride salt form of betazole, a histamine H2 receptor agonist with diagnostic application. Betazole selectively targets and binds to the H2 receptor, thereby mimicking the effect of histamine on these receptors. This may lead to an increase in gastric secretions. Betazole can be used in gastric function tests.\nConcepts: Betazole Hydrochloride (Pharmacologic Substance)\tPancreatic Tissue Extract (Tissue Extracts)\tmitochondrial mRNA catabolic process (Genetic Function)\tGAIA Level 4 Second Trimester Spontaneous Abortion (Intellectual Product)\tPRKACA protein, human (Protein-Serine-Threonine Kinases)", + "output": "Betazole Hydrochloride (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as functions and activities of the cardiovascular system as a whole or of any of its parts.\nConcepts: Cardiovascular Physiology (CARDIOVASCULAR FUNCTIONS: GENERAL TERMS)\t3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin (Organic Chemical)\tZirconium Zr 89 Trastuzumab (Radioimmunoconjugates)\tIncreased lactate dehydrogenase level (Abnormal lactate dehydrogenase level)\tSubdural space (Compartment of head)", + "output": "Cardiovascular Physiology (CARDIOVASCULAR FUNCTIONS: GENERAL TERMS)" + }, + { + "input": "Definition: Asteraceae described as a genus of ornamental plants in the family ASTERACEAE, often found near water.\nConcepts: Ligularia (Plant)\torganelle localization by membrane tethering (organelle localization)\t4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol Glucuronide (Organic Chemical)\tBDR2 (HPCA gene)\tPheresis Filters (Filter - medical device)", + "output": "Ligularia (Plant)" + }, + { + "input": "Definition: Samplers, Laboratory described as laboratory samplers designed to take samples using manual methods usually for testing procedures. Many manual samplers consist of tubes with some mechanism (e.g., a check valve) to prevent accidental spills and/or loss of liquid samples; others are configured to obtain samples of particulate materials. Samplers manufactured especially for manipulation of strong acids, viscous liquids, and other uses are also available. Manual samplers are available either as disposable plastic devices or reusable devices (which are typically made of stainless steel); some are supplied sterile. Specially designed scoops, ladles, spatulas, and other devices are also used to obtain samples in the clinical laboratory.\nConcepts: adult grade III meningioma (Grade III Meningioma)\tNutritional Component (Intervention regimes)\tSamplers, Laboratory, Manual (Samplers, Laboratory)\tubiquitin-protein transferase regulator activity (enzyme regulator activity)\tBCL1 (CCND1 gene)", + "output": "Samplers, Laboratory, Manual (Samplers, Laboratory)" + }, + { + "input": "Definition: Disease or Syndrome described as inflammation of the muscular walls of the heart.\nConcepts: Blood group antigen O (ABO blood grouping)\tSeminal Fluid (Body Substance)\tutilization (Functional Concept)\t3-26-27 MYOCARDITIDES (Vasculitis)\tStage IB Bone Cancer AJCC v8 (Stage I Bone Cancer AJCC v8)", + "output": "3-26-27 MYOCARDITIDES (Vasculitis)" + }, + { + "input": "Definition: Intellectual Product described as the automatic nature of accessing word meaning.\nConcepts: Repeat, WD40 (Amino Acid Sequence)\tStroop Paradigm (Intellectual Product)\ttransition mutation (Cell or Molecular Dysfunction)\tacetyl-CoA:corrinoid protein O-acetyltransferase activity (Molecular Function)\tbody discomfort (SENSORY FUNCTIONS AND DYSFUNCTIONS)", + "output": "Stroop Paradigm (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as human SLAMF1 wild-type allele is located in the vicinity of 1q23.3 and is approximately 39 kb in length. This allele, which encodes signaling lymphocytic activation molecule protein, plays a role in initiating signal transduction networks in immune cells.\nConcepts: SLAMF1 wt Allele (SLAMF1 gene)\tPlanned Activity Repeat Quantity Range (Quantitative Concept)\tMethylglyoxalase (Lyase)\tPKPARMCD (CDISC SDTM Terminology)\tRefractory B-Cell Prolymphocytic Leukemia (Neoplastic Process)", + "output": "SLAMF1 wt Allele (SLAMF1 gene)" + }, + { + "input": "Definition: HumanSubstanceAdministrationSite described as the distal half of the left upper limb between the elbow and the wrist.\nConcepts: elbows skin (Skin of part of upper limb)\tprotein localization to plasma membrane raft (Cell Function)\tEPHA2 (Gene or Genome)\tleft lower forearm (Body Location or Region)\tmeat (Food)", + "output": "left lower forearm (Body Location or Region)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent DNA helicase activity.\nConcepts: PUL 2.0 - Flexion Shoulder Height No Weights (Intellectual Product)\tIDSC109B (IDS-C Clinical Classification Question)\tDietary Folate Equivalent (Quantitative Concept)\tnegative regulation of ATP-dependent DNA helicase activity (negative regulation of DNA duplex unwinding)\t1-butanol anabolism (Molecular Function)", + "output": "negative regulation of ATP-dependent DNA helicase activity (negative regulation of DNA duplex unwinding)" + }, + { + "input": "Definition: Immunologic Tests described as a measurement of the human anti-sheep IgG antibodies in a biological specimen.\nConcepts: Well marginated (Finding)\tClark staging levels (Clark's melanoma level)\tKCS - Keratoconjunctivitis sicca (Diseases and Syndromes of Conjunctiva, Cornea and Sclera)\tMND - Motor neurone disease (Anterior Horn Cell Disease)\tHuman Anti-Sheep IgG Antibody Measurement (Laboratory Procedure)", + "output": "Human Anti-Sheep IgG Antibody Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as treatment Satisfaction Questionnaire for Medication - How easy or difficult is it to plan when you will use the medication each time?\nConcepts: OMC Profile (Microbiome)\tTSQM0110 (TSQM Version 1.4 Questionnaire Question)\tTr1 Cell (Cell)\tAELOC (Location)\tCriminal Injury (Injury or Poisoning)", + "output": "TSQM0110 (TSQM Version 1.4 Questionnaire Question)" + }, + { + "input": "Definition: Anatomical Abnormality described as underdevelopment of the anterior nasal spine of maxilla.\nConcepts: FAC005-I Am Bothered by Change in Weight (FACT-B Version 4 Questionnaire Question)\tSmall anterior nasal spine (Hypoplasia of the maxilla)\tPsychological fixation (psychosexual theory of personality development)\tUPD146 (UPDRS Questionnaire Question)\tGranules for oral suspension (Granule for Suspension Dosage Form)", + "output": "Small anterior nasal spine (Hypoplasia of the maxilla)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in both protein phosphorylation and signal transduction.\nConcepts: Recurrent joint dislocations (DISLOCATIONS AND ANKYLOSES)\tHuang Lian (Antineoplastic Plant Product)\tMEK2 (Signaling Pathway Gene)\tTherapeutic Results, Unexpected (Incorrect, Inadequate or Imprecise Result or Readings)\tActin Like 6B wt Allele (Gene or Genome)", + "output": "MEK2 (Signaling Pathway Gene)" + }, + { + "input": "Definition: Radioactive Diagnostic Agent described as a radiopharmaceutical containing flutemetamol, a thioflavin derivative of Pittsburgh compound B (PiB) labeled with the radioisotope fluorine F18 that can be used to detect beta-amyloid deposition upon positron emission tomography (PET). After intravenous administration of flutemetamol F 18, the flutemetamol moiety selectively accumulates in and binds to cerebral fibrillar amyloid-beta in the brain. The fluorine F18 radioisotope moiety is detected using PET, which allows imaging and quantification of amyloid-beta density. Amyloid plaque deposition is linked to cognitive decline, including Alzheimer's disease, and may be linked to chemotherapy-induced cognitive impairment (CICI).\nConcepts: anti-GD2 monoclonal antibody hu14.18K322A (Antineoplastic Antibody)\tdisturbances visuals (Nursing Assessment Entity)\tGastro-resistant granules (Delayed Release Dosage Form)\tregulation of kidney development (Organ or Tissue Function)\tFlutemetamol (18-F) (Element, Ion, or Isotope)", + "output": "Flutemetamol (18-F) (Element, Ion, or Isotope)" + }, + { + "input": "Definition: something described as nodal homolog (347 aa, ~40 kDa) is encoded by the human NODAL gene. This protein is involved in mesoderm formation and axial patterning.\nConcepts: Manages the length of operative or invasive procedure by planning care (Behavioral Responses: Patient and Family - Rights/Ethics/Competency)\tIntracystic papillary adenoca (Noninfiltrating intraductal papillary adenocarcinoma)\tup-regulation of branching involved in blood vessel morphogenesis (Positive Regulation of Angiogenesis)\tNODAL (Transforming Growth Factor beta)\tMetallic Object (Physical Object)", + "output": "NODAL (Transforming Growth Factor beta)" + }, + { + "input": "Definition: Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs Pathologic Primary Tumor TNM Finding v8 described as soft tissue sarcoma of the abdomen and thoracic visceral organs with tumor extending into tissue beyond organ.\nConcepts: lactotroph development (Cell development)\tPatchy sclerosis of the distal phalanx of the thumb (Patchy sclerosis of thumb phalanx)\tEC 2.7.11.22 (Enzyme)\tSoft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT2 TNM Finding v8 (Finding)\tIRF3:IRF3 complex location (Cell Component)", + "output": "Soft Tissue Sarcoma of the Abdomen and Thoracic Visceral Organs pT2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Medical Device described as insulin syringes, including a male fitting (Luer lock), designed to provide a locked, secure connection with a needle. Luer-lock tapers include an internally threaded skirt or other structure around the taper, adding additional strength to the connection with a female Luer taper.\nConcepts: Compression Units, Sequential (Medical Device)\tCommunication, Privileged (Thesaurus of Psychological Index Terms)\tSyringes, Plunger, Insulin, Luer Lock (Syringes, Plunger, Insulin)\tIVD Test Reagent/Kits, Immunoassay, Standard, Endocrine Hormone (Medical Device)\tChiropractic medicine (Specialty Type)", + "output": "Syringes, Plunger, Insulin, Luer Lock (Syringes, Plunger, Insulin)" + }, + { + "input": "Definition: Data described as data as originally collected. Distinct from derived. Raw data includes records of original observations, measurements, and activities (such as laboratory notes, evaluations, data recorded by automated instruments) without conclusions or interpretations. Researcher's records of subjects/patients, such as patient medical charts, hospital records, X-rays, and attending physician's notes. NOTE: These records may or may not accompany an application to a Regulatory authority, but must be kept in the researcher's file. See also eSource, source data, source documents.\nConcepts: Enlarged end part of the outermost bone of pinkie finger (Abnormality of the epiphysis of the distal phalanx of the 5th finger)\tExposure Location (Location)\t3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen)\tNAA10 wt Allele (Gene or Genome)\traw data (Intellectual Product)", + "output": "raw data (Intellectual Product)" + }, + { + "input": "Definition: Laboratory or Test Result described as a laboratory finding indicating that the subject expresses abnormal hemoglobin containing 2 variant forms of the hemoglobin subunit beta protein (HBB). One HBB protein variant has the amino acid substitution glutamic acid to valine at residue 6, which is associated with the formation of hemoglobin S (HbS), while the other variant has a glutamic acid to lysine substitution at residue 121, which is associated with the formation of hemoglobin O-Arab (HbO(Arab)). Subjects expressing this compound heterozygous HBB genotype may have severe sickling hemoglobinopathy with clinical manifestations similar to those of homozygous sickle cell anemia.\nConcepts: Hb S/O Arab (Abnormal Blood Chemistry and Hematology Test Result)\tCabinets, Storage, Instrument, Stand-Alone (Instrument storage cabinet)\tIVD Panels, Human Genetics, Metabolic Disorder, Diabetes, Diabetes Mellitus Type 2 (Medical Device)\tCaries Removal (Therapeutic or Preventive Procedure)\tProstate Acinar Adenocarcinoma, Atrophic Variant (Neoplastic Process)", + "output": "Hb S/O Arab (Abnormal Blood Chemistry and Hematology Test Result)" + }, + { + "input": "Definition: something described as a rare acquired localized lipodystrophy disorder characterized by the eruption of tender occasionally painful, erythematous nodules and plaques, which enlarge radially and resolve into lipoatrophic lesions, often located in the upper and lower limbs. Histologically lesions are characterized by lipophagic lobular panniculitis and absence of vasculitis.\nConcepts: Grade 2 Muscle Cramp, CTCAE (Finding)\tLocally Advanced Breast Carcinoma (Metastatic Breast Carcinoma)\tcyst dandy walkers (Cerebellar vermis hypoplasia)\tNeoplasm of Maxillofacial Sinus (location of neoplasm of sinus)\tPanniculitis induced localised lipodystrophy (Panniculitis)", + "output": "Panniculitis induced localised lipodystrophy (Panniculitis)" + }, + { + "input": "Definition: Syndrome described as a rare degenerative genetic disorder with an autosomal recessive pattern of inheritance that primarily affects the central nervous system. It is caused in some cases by mutations in the Cockayne syndrome group B gene, CSB/ERCC6, or the xeroderma pigmentosum genes: XPD/ERCC2, XPG/ERCC5, XPF/ERCC1, which are all involved in the transcription-coupled nucleotide excision repair pathway of DNA repair. It is currently thought to be part of the spectrum of disorders within Cockayne syndrome. Clinical signs at birth include microcephaly, hypotonia, abnormal reflexes and involuntary eye movements. The clinical prognosis is fatal with survivability beyond 5 years unlikely.\nConcepts: Surefire Antireflux Microcatheter (Arterial catheter)\tcongenital malformations nervous system cerebro-oculo-facio-skeletal syndrome (Rare Non-Neoplastic Disorder)\tTargeted Molecular Therapy Was Administered as an Additional Treatment for a New Tumor Event (Finding)\tSulfur product (Pharmacologic Substance)\tIdiopathic cutaneous hyperchromia at the orbital region (Skin, Human)", + "output": "congenital malformations nervous system cerebro-oculo-facio-skeletal syndrome (Rare Non-Neoplastic Disorder)" + }, + { + "input": "Definition: Classification described as the general substance class of the test article, based on physical, biochemical, and/or other composition of matter properties.\nConcepts: cis-hexadecenoic acid (Organic Chemical)\tmyoblast fusion involved in skeletal muscle regeneration (myoblast fusion)\t6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex (Cell Component)\tTest Article Physical Substance Classification (Class)\tIVD Test Reagent/Kits, Serology, Virus, Epidemic Parotitis (Medical Device)", + "output": "Test Article Physical Substance Classification (Class)" + }, + { + "input": "Definition: something described as the set of characteristics by which a thing or person is recognized or known and that constitutes it's individuality or set inclusion.\nConcepts: peptidyl-serine racemization (peptidyl-L-amino acid racemization)\tmice (Rodent)\tIVD Test Reagent/Kits, Serology, Virus, Parainfluenza 3, IgG Antibody (IVD Test Reagent/Kits, Serology, Virus, Parainfluenza, Antibody)\tSwine (Mammal)\tidentities (Psychology)", + "output": "identities (Psychology)" + }, + { + "input": "Definition: Quantitative Concept described as the first aortic systolic pressure peak, also referred to as a forward wave, used to calculate the aortic augmentation index.\nConcepts: Thorium dioxide (Oxides)\tFeature Dimension (Conceptual Entity)\tGrade 2 Neonatal Bradyarrhythmia, AE (Finding)\tAAUGPRP1 (Physical Phenomenon or Property)\tPharyngoesophageal Segment Opening (Finding)", + "output": "AAUGPRP1 (Physical Phenomenon or Property)" + }, + { + "input": "Definition: Immunoglobulin measurement described as a measurement of the Bermuda grass (Cynodon dactylon) pollen IgG in a biological specimen.\nConcepts: Bermuda Grass Pollen IgG Measurement (Laboratory Procedure)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly)\tage-related resistance (Immunity, Innate)\tFibuloulnar hypoplasia with renal abnormalities (Autosomal recessive hereditary disorder)\tprotein localisation to kinetochore (Cell Function)", + "output": "Bermuda Grass Pollen IgG Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: regulation of signal transduction described as any process that modulates the frequency, rate or extent of the torso signaling pathway.\nConcepts: monoclonal antibody CTLA-4 (Antibodies, Neoplasm)\tCutaneous gonorrhoea (Gonococcemia)\tTriamterene product (Pteridines)\tIncreased urinary sulfite (LABORATORY ABNORMALITIES)\tregulation of torso signaling pathway (regulation of signal transduction)", + "output": "regulation of torso signaling pathway (regulation of signal transduction)" + }, + { + "input": "Definition: Temporal Concept described as a period of time consisting of the 28 days before the present.\nConcepts: TSQM Version 1.4 - Satisfied or Dissatisfied With Medication (TSQM Version 1.4 Questionnaire Question)\tPursuits, Smooth (Nystagmus)\tSnores (Lungs and Breathing)\tLast 4 Weeks (Period)\tbromeliad family (Poales)", + "output": "Last 4 Weeks (Period)" + }, + { + "input": "Definition: Sites of Care Delivery described as temporary housing for displaced or at-risk persons.\nConcepts: Shelter facility (Sites of Care Delivery)\tupregulation of chanoclavine-I anabolism (Molecular Function)\tManufacturing, Packaging or Shipping Problem (Finding)\tDental Amalgam Condensers (Dental equipment and devices)\tCalcium gluconate (Calcium supplement agent)", + "output": "Shelter facility (Sites of Care Delivery)" + }, + { + "input": "Definition: something described as a partial duplication, depending on severity leading to a broad or bifid appearance, affecting one or more of the distal phalanges of the hand. As opposed to a complete duplication there is still a variable degree of fusion between the duplicated bones.\nConcepts: Aquifex (Bacterium)\tRhodococcus species (Subclass Nocardioform Actinomycetes)\tBifid terminal phalanges of the hand (Partial duplication of the phalanx of hand)\tCNS Involvement Criteria (criteria)\tNCCN-FACT FBRSI-24 Version 2 - I Need Help in Caring for Myself (Intellectual Product)", + "output": "Bifid terminal phalanges of the hand (Partial duplication of the phalanx of hand)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation described as molecular assay reagents intended to identify mutations in the glycyl-tRNA synthetase (GARS) gene, located at chromosome 7p15, which encodes the protein glycine-tRNA ligase. Genetic variants at this locus have been associated with distal hereditary motor neuronopathy and Charcot-Marie-Tooth disease.\nConcepts: Weight Distribution Analyzers, Patient (Analyzers, Physiologic, Neuromuscular Function)\tShortness of Breath Score 3 (Intellectual Product)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GARS (Medical Device)\tHAQ0136 (HAQ-DI Questionnaire Question)\tFree and Sovereign State of Michoacan (Geographic Area)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GARS (Medical Device)" + }, + { + "input": "Definition: something described as any elsewhere undefined Oriental herb and natural substance, letter N, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: Weak frontalis muscle (Face)\tCapacitor (Manufactured Object)\tAnesthesia ventilator (Anesthesia and respiratory device)\tUndefined Oriental herb and natural substance letter N narrative required (Plant)\touter layer of an organ (Body Part, Organ, or Organ Component)", + "output": "Undefined Oriental herb and natural substance letter N narrative required (Plant)" + }, + { + "input": "Definition: Biologically Active Substance described as all homeodomain proteins contain the homeodomain, a region of structural similarity present in certain prokaryotic and eukaryotic DNA-binding proteins. Eukaryotic homeodomain proteins are encoded by homeobox genes and typically control gene expression during morphogenesis and development.\nConcepts: Undertaking a complex task (Functional Concept)\tHomeodomain Protein (Amino Acid, Peptide, or Protein)\tEsophageal Motility Analyzers (Analyzers, Physiologic, Peristaltic Motility)\tCompounding Sterile Product (Activity)\tpositive regulation of cell fate determination (Cell Function)", + "output": "Homeodomain Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Arterial Occlusive Diseases described as blocking or clogging of the renal artery, which is the branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.\nConcepts: Hyperlipoproteinemia (Disease or Syndrome)\tERBB2-EGFR signalling pathway (Molecular Function)\tPRESENILIN 02 (Presenilins)\tRenal artery obstruction (Kidney Diseases)\tcerebellar granule cell precursor tangential migration (Cell Function)", + "output": "Renal artery obstruction (Kidney Diseases)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of vesicle docking.\nConcepts: Shock Syndrome (TSS), Toxic (Staphylococcal Infections)\tregulation of vesicle to membrane docking (regulation of cellular localization)\tMicroscopist 2 (Professional or Occupational Group)\tBeam Hardening Artifact (CT Image Artifact)\tMRI, Diffusion Weighted (Magnetic Resonance Imaging)", + "output": "regulation of vesicle to membrane docking (regulation of cellular localization)" + }, + { + "input": "Definition: Finding described as JFK Coma Recovery Scale-Revised - Total score.\nConcepts: LmddA-LLO-chHER2 Fusion Protein-secreting Live-attenuated Listeria Cancer Vaccine ADXS31-164 (Cancer Vaccines)\t2-oxo-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo[a]quinolizine (Vesicular monoamine transporter 2 inhibitor)\tCRSR0111 (CRS-R Clinical Classification Question)\tRho GTPase-Binding Protein 1 (Signaling Protein)\tCordonnier Grade 3 Parasitic Complication, Pneumocystis jiroveci Pneumonia (Intellectual Product)", + "output": "CRSR0111 (CRS-R Clinical Classification Question)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+).\nConcepts: Grade 3 Neonatal Constipation, Adverse Event (Finding)\t3,7-dimethylquercetin 4'-O-methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)\tRight Posterior Apical Transition Zone of Prostate (Transition zone of prostate)\tpositive regulation of DNA formation (positive regulation of macromolecule biosynthetic process)\tPicogram per Milliliter per Microgram per Meter Squared per Day (Quantitative Concept)", + "output": "3,7-dimethylquercetin 4'-O-methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)" + }, + { + "input": "Definition: Area Under First Moment Curve described as the area under the first moment curve (AUMC) for the defined interval between doses (TAU) divided by the body mass index.\nConcepts: AUMCTAUB (Area Under First Moment Curve)\tBeam - rays of radiation or stream of particles (Physical Phenomenon or Property)\tupregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation (positive regulation of regulatory T cell differentiation)\tEstimated Creatinine Clearance (Laboratory Procedure)\tConcurrent Chemoradiation (Chemoradiotherapy)", + "output": "AUMCTAUB (Area Under First Moment Curve)" + }, + { + "input": "Definition: Cell Function described as the directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.\nConcepts: Tokelauan (Ethnicity / related nationality data - finding)\tThymic Germ Cell Tumor T1 TNM Finding (Mediastinal Germ Cell Tumor Primary Tumor TNM Finding)\tSoft Tissue Sarcoma of the Trunk and Extremities cM0 TNM Finding v8 (Soft Tissue Sarcoma of the Trunk and Extremities Clinical Distant Metastasis TNM Finding v8)\tendosome transport via MVB sorting pathway (Cell Function)\tnegative regulation of hippocampal neuron apoptotic process (negative regulation of neuron apoptotic process)", + "output": "endosome transport via MVB sorting pathway (Cell Function)" + }, + { + "input": "Definition: Dementia described as a neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)\nConcepts: AIDS Related Dementia Complex (Acquired Immunodeficiency Syndrome)\tCerebral malaria (Brain Diseases)\tPhysicians; Physician/Osteopath; Neurology, Child (Physicians; Physician/Osteopath)\tTuberculosis luposa cutis (Tuberculosis)\tmitotic telomere clustering and tethering at nuclear periphery (Genetic Function)", + "output": "AIDS Related Dementia Complex (Acquired Immunodeficiency Syndrome)" + }, + { + "input": "Definition: something described as the series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.\nConcepts: Platelet Factor 4 (Amino Acid, Peptide, or Protein)\tNSAA1-Stands on Heels (NSAA Clinical Classification Question)\tEmbryonic Ventricle (Embryonic Structure)\tsalty taste perception (Taste Perception)\tAnnual Reports (Intellectual Product)", + "output": "salty taste perception (Taste Perception)" + }, + { + "input": "Definition: Triglyceride Metabolism described as the chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol.\nConcepts: Lung Inflammation, Experimental (Experimental Model of Disease)\tribonucleoprotein complex subunit organisation (protein-containing complex subunit organization)\tConcentrated Solution Dosage Form (Concentrate Dosage Form)\tREFLEX LOSS (Reflex Motor and Equilibrium Functions)\ttriglyceride catabolism (Triglyceride Metabolism)", + "output": "triglyceride catabolism (Triglyceride Metabolism)" + }, + { + "input": "Definition: something described as an alteration of the septum from the midline. This is typically seen in the nasal cavity.\nConcepts: Interrupted Family Process (Finding of role relationship pattern)\tadult nasal type extranodal natural killer/T-cell lymphoma (Adult Non-Hodgkin Lymphoma)\tCAS Registry (NCI Thesaurus Property)\tdeflected septum (Nose)\tESCRT IV complex location (ATPase complex)", + "output": "deflected septum (Nose)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.\nConcepts: upregulation of cardiac muscle fiber development (regulation of cardiac muscle fiber development)\tSUPPOSITORY (Solid Dose Form)\tQ-LES-Q - Felt Clearheaded (Intellectual Product)\tblood vessel development (Organ or Tissue Function)\tAtracurium-containing product (Pharmacologic Substance)", + "output": "blood vessel development (Organ or Tissue Function)" + }, + { + "input": "Definition: Neoplastic Process described as a Hodgkin lymphoma with unfavorable prognosis.\nConcepts: Unfavorable Hodgkin Lymphoma (Neoplastic Process)\tLab Manual (Manuals as Topic)\tSelf-care assistance: bathing/hygiene (Therapeutic or Preventive Procedure)\tdry hair (Texture of hair - finding)\tMachiavellianism (Mental Process)", + "output": "Unfavorable Hodgkin Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare form of hereditary optic atrophy seen in only 4 families to date. With onset in early childhood the disease has characteristics of progressive loss of visual acuity, significant optic nerve pallor and occasionally additional neurological manifestations, with females being unaffected.\nConcepts: carcinoma of the uterus, clearcell (Malignant neoplasm of endometrium)\tNon-Leber type optic atrophy with early-onset (Congenital atrophy of optic nerve)\tVascular Sequential Compression Devices (Medical Device)\tPeripheral vitreoretinal degeneration (Finding)\tnegative regulation of erythrocyte enucleation (negative regulation of cell maturation)", + "output": "Non-Leber type optic atrophy with early-onset (Congenital atrophy of optic nerve)" + }, + { + "input": "Definition: something described as an abnormal purple color of the urine. []\nConcepts: maltose metabolic process (Molecular Function)\tcell polarity (Cytology)\tOrbicular ligament of radius (Body Part, Organ, or Organ Component)\tPurple urine (Urine Discoloration)\tstimulus sensitivity (Conceptual Entity)", + "output": "Purple urine (Urine Discoloration)" + }, + { + "input": "Definition: something described as damage to the jugular vein from traumatic or pathologic processes.\nConcepts: Wound stick (Stick Dosage Form)\trenal vesicle morphogenesis (morphogenesis of an epithelium)\tplay (Behavior)\tIntervention for Kawasaki Disease, Medications (Therapeutic or Preventive Procedure)\tInjury to jugular vein (Injury or Poisoning)", + "output": "Injury to jugular vein (Injury or Poisoning)" + }, + { + "input": "Definition: Abnormal T cell activation described as any abnormality in the upregulation of CD25 on T cells after activation via the T cell receptor (TCR). CD25 is the alpha chain of the IL2 receptor. Ligation of the T cell antigen receptor leads to the induction of CD25 expression.\nConcepts: formylaminopyrimidine deformylase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tEpidural Hematoma, Intracranial (Pathologic Function)\tPARTNER-DDS - More I Try The Worse Things Get (PARTNER-DDS Questionnaire Question)\tAbnormal CD25 upregulation upon TCR activation (Abnormal T cell activation)\tLow maternal serum alpha-fetoprotein (Finding)", + "output": "Abnormal CD25 upregulation upon TCR activation (Abnormal T cell activation)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as methionine synthase (1265 aa, ~141 kDa) is encoded by the human MTR gene. This protein plays a role in the methylation of homocysteine.\nConcepts: Normal sleep (Intellectual Product)\tUnspecified Type Delusional Disorder (Mental or Behavioral Dysfunction)\tVitamin-B12 Dependent Methionine Synthase (Enzyme)\tODI v2.1a Questionnaire Question (Clinical or Research Assessment Question)\tAbdominal structure (Region of trunk)", + "output": "Vitamin-B12 Dependent Methionine Synthase (Enzyme)" + }, + { + "input": "Definition: something described as catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP.\nConcepts: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor (oxidoreductase activity, acting on NAD(P)H)\tWARFARIN SODIUM (Coumarin Compound)\tVAS (Intellectual Product)\tBase Pair Miscoding (Genetic Function)\tMercurius cyanatus / mercury cyanide (Homeopathic remedies letter M)", + "output": "oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor (oxidoreductase activity, acting on NAD(P)H)" + }, + { + "input": "Definition: Gene or Genome described as human MCC wild-type allele is located in the vicinity of 5q21-q22 and is approximately 360 kb in length. This allele, which encodes colorectal mutant cancer protein, may play a role in tumor suppression. MCC wild-type allele is a candidate colorectal tumor suppressor gene.\nConcepts: Acetyl-CoA:orthophosphate acetyltransferase (Acetyltransferase)\tAbutment tooth condition substantially compromised, 3 sextants (Abutment tooth condition finding)\tMCC wt Allele (Gene or Genome)\tTuning Forks (Medical Devices)\tU251 (NCI-60 Cell Line)", + "output": "MCC wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Neoplastic Process described as a term that refers to the staging of rectosigmoid carcinoma according to the American Joint Committee on Cancer, 6th edition.\nConcepts: Colchicaceae DC., 1804 (Plant)\tIlex aquifolium preparation (Organic Chemical)\tRectosigmoid Cancer by AJCC v6 Stage (Colorectal Cancer by AJCC v6 Stage)\t3p24.1-p22 (Cell Component)\tCu+ (Element, Ion, or Isotope)", + "output": "Rectosigmoid Cancer by AJCC v6 Stage (Colorectal Cancer by AJCC v6 Stage)" + }, + { + "input": "Definition: something described as an International Prognostic Scoring System for Myelodysplastic Syndrome risk score of 0, corresponding to low risk.\nConcepts: Multicatalytic Endopeptidase Complex Subunit MECl-1 (Enzyme)\tprorubricyte (Cell)\tNumber of Moderate Episodes (Quantitative Concept)\tMixed Embryonal Carcinoma and Teratoma (Primary malignant neoplasm)\tIPSS Risk Score 0 (IPSS Risk Score)", + "output": "IPSS Risk Score 0 (IPSS Risk Score)" + }, + { + "input": "Definition: something described as the heavy chain of the immunoglobulin, IgD, is defective. This multiple myeloma subtype is very rare (~1%).\nConcepts: Grade 1 Weight gain (Finding)\tLifting Wheelchairs (Medical Device)\tFibroblast Growth Factor-9 Gene Amplification (Cell or Molecular Dysfunction)\tMultiple Myeloma-IgD (Finding)\tSECRET RATE (Quantitative Concept)", + "output": "Multiple Myeloma-IgD (Finding)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a procedure in which tissue is broken up into small fragments by ultrasound and then removed by aspiration.\nConcepts: Defect Type Code (Intellectual Product)\tMalignant lymphomatous polypos (Diffuse low grade B-cell lymphoma)\tAnatomic region (Latvian translation of the Medical Subject Headings)\tultrasonic surgical aspiration (Aspiration-action)\tFILE, PULP CANAL, ENDODONTIC (Medical Device)", + "output": "ultrasonic surgical aspiration (Aspiration-action)" + }, + { + "input": "Definition: cellular response to organic cyclic compound described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 2,3,7,8-tetrachlorodibenzodioxine stimulus.\nConcepts: Hyperinsulin-panc islet B cell (Hyperinsulinism)\tdutasteride (5-alpha Reductase Inhibitors)\tAlcohol cirrhosis liver (Hepatic fibrosis and cirrhosis)\tcellular response to TCDD (Cell Function)\tMalignant Neoplasm of Lower Jaw Bone (Mandibular Neoplasms)", + "output": "cellular response to TCDD (Cell Function)" + }, + { + "input": "Definition: something described as minutes times moles per liter (area under the curve), divided by meters squared (surface area).\nConcepts: Galactose-1-Phosphate Uridylyltransferase (Enzyme)\tFAC016-I Have Nausea (Intellectual Product)\tHAQ-DI Without VAS - Help: Eating (HAQ-DI Without VAS Questionnaire Question)\tmin.mol/L/m2 (Measurement Unit Description)\tPerformed Medical Record Abstraction (Chart Abstraction)", + "output": "min.mol/L/m2 (Measurement Unit Description)" + }, + { + "input": "Definition: something described as a clinical finding about one or more characteristics of vaginal cancer, following the rules of the TNM AJCC v7 classification system.\nConcepts: SLC12A7 wt Allele (SLC12A7 gene)\tVaginal Cancer Clinical TNM Finding v7 (Vaginal Cancer TNM Finding v7)\tEstimated complex carbohydrate intake in 24 hours (Nutrient Intake)\tBeta Interferon (Immunologic Factor)\tPlasminogen Activator Inhibitor-1 AG (Immunologic Tests)", + "output": "Vaginal Cancer Clinical TNM Finding v7 (Vaginal Cancer TNM Finding v7)" + }, + { + "input": "Definition: Finding described as problem associated with a partial linking of the device whereby the device may appear to be connected however only a partial, intermittent or no transfer of liquid, gas, electricity, or information can be accomplished.\nConcepts: Intermediate Grade (Histopathologic Grade)\tgibberellic acid mediated signaling pathway, G-alpha-independent (gibberellic acid mediated signaling pathway)\teupatolide synthase activity (monooxygenase activity)\tIncomplete or Inadequate Connection (Connection Problem)\ttyrosine-ester sulfotransferase activity (sulfotransferase activity)", + "output": "Incomplete or Inadequate Connection (Connection Problem)" + }, + { + "input": "Definition: Protein Tyrosine Kinase described as a protein tyrosine kinase that is required for T-CELL development and T-CELL ANTIGEN RECEPTOR function.\nConcepts: cellubrevin-VAMP4-endobrevin-syntaxin-6 complex (Cell Component)\tZAP-70 Protein (Enzyme)\tC5 Inhibitor RA101495 (Organic Chemical)\tSubstance with proteasome inhibitor mechanism of action (Protease Inhibitors)\tManagement of thrombolytic therapy (Therapeutic or Preventive Procedure)", + "output": "ZAP-70 Protein (Enzyme)" + }, + { + "input": "Definition: something described as a species of MORBILLIVIRUS causing cattle plague, a disease with high mortality. Sheep, goats, pigs, and other animals of the order Artiodactyla can also be infected.\nConcepts: integral component of plastid membrane (Cell Component)\trinderpest virus RV (Virus)\tC130071 (Immunoglobulin measurement)\tregulation of plus-end F-actin capping activity (regulation of actin filament depolymerization)\tapazone (A [Preparations])", + "output": "rinderpest virus RV (Virus)" + }, + { + "input": "Definition: Medical Device described as trend graphic recorders used to record the patient's temperature.\nConcepts: response to leptomycin B (response to fatty acid)\tnegative regulation of brassinosteroid biosynthetic process (regulation of brassinosteroid biosynthetic process)\tTemperature Trend Physiologic Recorders (Medical Device)\tpositive regulation of proline metabolic process (positive regulation of cellular amino acid metabolic process)\tPAR-6 (Gene or Genome)", + "output": "Temperature Trend Physiologic Recorders (Medical Device)" + }, + { + "input": "Definition: Family Group described as any individual related biologically or legally to another individual and residing in the same residence.\nConcepts: Palliative Care (Hospice and Palliative Care Nursing)\tstatu (Linkage concept)\tcystic; mastopathy (Disease or Syndrome)\ta-GalCer (Organic Chemical)\tHousehold Relative (Relative)", + "output": "Household Relative (Relative)" + }, + { + "input": "Definition: Pharmacologic Substance described as acridines which are substituted in any position by one or more amino groups or substituted amino groups.\nConcepts: Performed Protocol Deviation Subcategory Code (Subcategory Code)\tstem (Intellectual Product)\tAminoacridines (Pharmacologic Substance)\tEnteral Tube Irrigation (Maintenance of gastrointestinal tract tube)\tBFD (Gene or Genome)", + "output": "Aminoacridines (Pharmacologic Substance)" + }, + { + "input": "Definition: Pharmacologic Substance described as opium, dried latex of poppy.\nConcepts: K188R (Finding)\tA-kinase anchoring protein 2 (Gene or Genome)\tperipheral B-cell tolerance induction (B cell tolerance induction)\tCommunication Aids, Voice Synthesizer (Technical Aids for the Disabled)\tpapapver somniferum/opium/dr (Homeopathic remedies letter P)", + "output": "papapver somniferum/opium/dr (Homeopathic remedies letter P)" + }, + { + "input": "Definition: Histoplasmosis described as histoplasmosis is caused by the fungus Histoplasma capsulatum and is consider to be an opportunistic infection in immunosuppressed persons.\nConcepts: alpha-2-HS-glycoprotein, human (Regulatory Protein)\tVery Well (Finding)\tosteoclast fusion (syncytium formation by plasma membrane fusion)\tteratoma extragonadal (Neoplastic Process)\tHistoplasma infections (Infection)", + "output": "Histoplasma infections (Infection)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the ratio of clefted lymphocytes compared to leukocytes present in a sample. The measurement may be expressed as a ratio or percentage.\nConcepts: Likert Score 5 (Clinical or Research Assessment Answer)\tClefted Lymphocytes to Leukocytes Ratio Measurement (Laboratory Procedure)\tGynatresias (Female Genital Diseases)\tbone plates (ORTHOPEDIC DEVICES AND HARDWARE)\tPOLIOVIRUS (P [Preparations])", + "output": "Clefted Lymphocytes to Leukocytes Ratio Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as human CFTR wild-type allele is located in the vicinity of 7q31.2 and is approximately 203 kb in length. This allele, which encodes cystic fibrosis transmembrane conductance regulator protein, plays a role in the transport of chloride ions. Mutation of the gene is associated with cystic fibrosis and congenital bilateral absence of the vas deferens.\nConcepts: CCL22, Chemokine (Immunologic Factor)\tData Collection Instrument (Intellectual Product)\tCanine Prostate Carcinoma (Neoplastic Process)\tABC35 (CFTR gene)\tHodgkin's disease, stage IV, adult (stage, adult Hodgkin lymphoma)", + "output": "ABC35 (CFTR gene)" + }, + { + "input": "Definition: something described as radiographic/tomographic systems that use a pattern of x-ray tube movement (e.g., spiral, elliptical, circular) that provides blurring in both directions of the plane. These systems are mostly used to examine the lungs and other soft tissue having little natural contrast, particularly using narrow-angle tomography (i.e., zonography).\nConcepts: NAD+ ADP ribosyltransferase 1 (Enzyme)\tRadiographic/Tomographic Systems, Multidirectional (Medical Device)\tregulation of mRNA 3'-end processing (Genetic Function)\tmodulation of transmission of nerve impulse in other organism (modulation of process of other organism)\tStethescope (Medical Devices)", + "output": "Radiographic/Tomographic Systems, Multidirectional (Medical Device)" + }, + { + "input": "Definition: something described as a mixed backbone oligonucleotide exhibiting antitumor activity. GEM-231 is complementary to the RI alpha subunit of Protein Kinase A (PKA), resulting in downregulation of PKA expression and ultimately tumor growth.\nConcepts: GEM 231 (Nucleic Acid, Nucleoside, or Nucleotide)\tregulation of pseudohyphal septin ring assembly (regulation of cytoskeleton organization)\tSebaceous Gland Alteration (Organ or Tissue Function)\tUDP-glucose: 9-methylthiononylhydroximate S-glucosyltransferase activity (Molecular Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SMAD4 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)", + "output": "GEM 231 (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Vaginal Cancer Pathologic Primary Tumor TNM Finding v7 described as vaginal cancer extending to the pelvic wall. Pelvic wall is defined as muscle, fascia, neurovascular structures, or skeletal portions of the bony pelvis.\nConcepts: Carboplatin Regimen (Regimen Used to Treat Merkel Cell Carcinoma)\tradotinib hydrochloride (Protein-tyrosine kinase inhibitor)\tHodgkin's disease, stage III, childhood (stage, childhood Hodgkin lymphoma)\tVaginal Cancer pT3 TNM Finding v7 (Finding)\tAnhydrous, Thioguanine (Antimetabolite [EPC])", + "output": "Vaginal Cancer pT3 TNM Finding v7 (Finding)" + }, + { + "input": "Definition: something described as cyclohexanes which contain two double bonds in the ring.\nConcepts: Arthrodesis of joint, NOS (Fusion procedure)\tCyclohexadienes (Organic Chemical)\tHistone H4 (Histones)\tCRYSTALLOGR (Chemistry, Physical)\tImmunohistochemistry Was Not Performed (Testing Was Not Preformed)", + "output": "Cyclohexadienes (Organic Chemical)" + }, + { + "input": "Definition: something described as a focal cognitive seizure with dysgraphia / agraphia characterized by impairment of awareness at some point during the seizure.\nConcepts: Access Control Keypads (Keypads)\tGreat Pyrenee dog (Dog family)\tTime Activity Curve (Quantitative Concept)\tFocal impaired awareness cognitive seizure with dysgraphia/agraphia (Disease or Syndrome)\tGastric xanthelasma (Xanthomatosis)", + "output": "Focal impaired awareness cognitive seizure with dysgraphia/agraphia (Disease or Syndrome)" + }, + { + "input": "Definition: C-SSRS Since Last Visit Questionnaire Question described as columbia-Suicide Severity Rating Scale Since Last Visit - Description of active suicidal ideation with specific plan and intent.\nConcepts: X-Linked Genetic Diseases (Disease or Syndrome)\tmesonephric extraglomerular mesangial cell proliferation involved in mesonephros development (extraglomerular mesangial cell proliferation)\tSpontaneous hematomas (Skin, Human)\tphosphatidate kinase activity (phosphotransferase activity, phosphate group as acceptor)\tCSS02-Ideation With Plan/Intent, Descr (Intellectual Product)", + "output": "CSS02-Ideation With Plan/Intent, Descr (Intellectual Product)" + }, + { + "input": "Definition: Organic Chemical described as substituted derivatives of hydrazine (formula H2N-NH2).\nConcepts: adrenodoxin (Iron-Sulfur Proteins)\tTARP Antibody (Amino Acid, Peptide, or Protein)\tModular Medical Facilities (Protective Devices)\tColumbia-Suicide Severity Rating Scale Baseline Questionnaire (Clinical or Research Assessment Questionnaire)\thydrazines (Organic Chemical)", + "output": "hydrazines (Organic Chemical)" + }, + { + "input": "Definition: Healthcare Issues for Children and Teenagers described as subtype of diabetes mellitus that is characterized by insulin deficiency; it is manifested by the sudden onset of severe hyperglycemia, rapid progression to diabetic ketoacidosis, and death unless treated with insulin; the disease may occur at any age, but is most common in childhood or adolescence.\nConcepts: juvenile-onset diabetes mellitus (Korean Standard Classification of Disease Version 5)\tArchive (Intellectual Product)\tShip (Manufactured Object)\tUDP-N-acetyl-alpha-D-quinovosamine dehydrogenase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tImpaired von Willibrand factor collagen binding activity (Finding)", + "output": "juvenile-onset diabetes mellitus (Korean Standard Classification of Disease Version 5)" + }, + { + "input": "Definition: something described as the device does not collect or transfer the sample as intended.\nConcepts: Grass Mix Pollen Antigen IgE Antibody Measurement (Laboratory Procedure)\tFailure to Obtain Sample (Medical Device Operates Differently Than Expected)\tExperimental Sarcomas (Experimental Model of Disease)\ttraining program (vocational and professional education)\ttRNA adenosine deamination to inosine (Genetic Function)", + "output": "Failure to Obtain Sample (Medical Device Operates Differently Than Expected)" + }, + { + "input": "Definition: Genetic Function described as the set of processes involved in identifying and degrading defective or aberrant RNAs.\nConcepts: RNA surveillance (Genetic Function)\taccessory olfactory bulb, granular layer (Body Part, Organ, or Organ Component)\tMaintaining vocational training program (Educational Activity)\tcity of boston (Cities)\tVictimization (Human-caused Phenomenon or Process)", + "output": "RNA surveillance (Genetic Function)" + }, + { + "input": "Definition: something described as iodine-induced hypothyroidism.\nConcepts: Wolff-Chaikoff Phenomenon (Disease or Syndrome)\tnucleus migration to megagametophyte poles (Cell Function)\tNanomoles per milliliter (Quantitative Concept)\tpicokatal (SI unit of catalytic amount)\tCAMEROON (Geographic Area)", + "output": "Wolff-Chaikoff Phenomenon (Disease or Syndrome)" + }, + { + "input": "Definition: Clinical or Research Facility described as the Genomics and Proteomics Shared Resource is an integrated resource that provides genomic and proteomic technologies to the Cancer Center investigators for basic and clinical research applications including DNA and RNA isolation, DNA sequencing, serial analysis of gene expression library production, SNP genotyping, STRP genotyping, microarray analysis, quantitative RT-PCR, protein identification and sequencing and profiling.\nConcepts: Heterozygous (Genotype)\tPravastatina (Naphthalenes)\tFailure of urine formation (Urinary system finding)\tJoint Deformities, Acquired (Arthropathy)\tGenomics and Proteomics Shared Resource (Clinical or Research Facility)", + "output": "Genomics and Proteomics Shared Resource (Clinical or Research Facility)" + }, + { + "input": "Definition: Thoracic Diseases described as mirror-image transposition of the abdominal and/or thoracic viscera. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)\nConcepts: Malignant Breast Spiradenoma (Neoplastic Process)\tCircumferential Endothelial Hyperplasia (Pathologic Function)\tNCI-Navy Medical Oncology Branch (Organization)\tSITUS INVERSUS (Disorder by body site)\tMOSAICISM (Chromosomal abnormalities NEC)", + "output": "SITUS INVERSUS (Disorder by body site)" + }, + { + "input": "Definition: Molecular Function described as the modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone.\nConcepts: Bleeding Reduction: Gastrointestinal (Procedure on gastrointestinal tract)\tTLR9 Receptor (DNA-Binding Proteins)\thistone H3-S28 phosphorylation (histone-serine phosphorylation)\tMucosal Melanoma of the Head and Neck Clinical Distant Metastasis TNM Finding v7 (Mucosal Melanoma of the Head and Neck Clinical TNM Finding v7)\tacrylonitrile catabolism (xenobiotic catabolic process)", + "output": "histone H3-S28 phosphorylation (histone-serine phosphorylation)" + }, + { + "input": "Definition: Molecular Function described as combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity.\nConcepts: external iliac artery (Structure of iliac artery)\tcalcitonin gene-related peptide receptor activity (calcitonin family receptor activity)\t3-(1H-indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4- yl)-1H-pyrrole-2,5-dione acetate (Protein Kinase C Inhibitor)\tb3 vitamins (Laboratory Procedure)\tINTERLOCUTORY (Finding)", + "output": "calcitonin gene-related peptide receptor activity (calcitonin family receptor activity)" + }, + { + "input": "Definition: FDA Technical Specification Name and Version described as version 4.3 of the FDA Study Data Technical Conformance Guide.\nConcepts: Tunica fibrosa hepatis (Dense irregular connective tissue)\tEtioplasts (Plastids)\tthrombocytopenic; purpura, idiopathic (Autoimmune thrombocytopenia)\tFDA Study Data Technical Conformance Guide v4.3 (Intellectual Product)\tPALM2 (Structural gene)", + "output": "FDA Study Data Technical Conformance Guide v4.3 (Intellectual Product)" + }, + { + "input": "Definition: Reconstructive Surgical Procedures described as restoring, to the extent possible, the natural anatomical structure\nConcepts: ATP Binding Cassette Transporter, Sub-Family D, Member 1 (ATP Binding Cassette Transporter, Subfamily D)\tDevice Carcinogenic Problem (Finding)\trepair (Surgical repair)\tCyclonic Storms (Environmental event)\tGliocladium species (Mitosporic Fungi)", + "output": "repair (Surgical repair)" + }, + { + "input": "Definition: CCAAT-Enhancer-Binding Proteins described as a CCAAT-enhancer-binding protein found in LIVER; ADIPOSE TISSUE; INTESTINES; LUNG; ADRENAL GLANDS; PLACENTA; OVARY and peripheral blood mononuclear cells (LEUKOCYTES, MONONUCLEAR). Experiments with knock-out mice have demonstrated that CCAAT-enhancer binding protein-alpha is essential for the functioning and differentiation of HEPATOCYTES and ADIPOCYTES.\nConcepts: C EBP alpha (CCAAT-Enhancer-Binding Proteins)\tADCS-ADL - Number of 'Don't Know' Responses (ADCS-ADL Questionnaire Question)\tPTEN Tyrosine Phosphatase L182* (PTEN Protein Variant)\tTraining Program (Educational Activities)\tanther wall tapetum cell differentiation (Cell Function)", + "output": "C EBP alpha (CCAAT-Enhancer-Binding Proteins)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a radioimmunoconjugate composed of a monoclonal antibody that targets an antigen overexpressed in pancreatic and ovarian cancer and labeled with the radioisotope zirconium Zr 89, with potential use for assessing tumor antigen expression using positron emission tomography (PET). Upon administration of zirconium Zr 89-labeled monoclonal antibody MMOT0530A, this agent targets an antigen expressed on certain tumor cells and is internalized. Following tumor cell uptake, the radioisotope moiety can be visualized using PET imaging. This may result in both the quantification of tumor antigen expression and an assessment of the response to treatment with therapeutics targeting the antigen.\nConcepts: 89Zr-MMOT0530A (Radioimmunoconjugates)\tGastric perforation (Gastrointestinal Disorders, CTCAE)\tBSE (Examination of breast)\tHemangiopericytoma, NOS (Hemangiopericytic Neoplasm)\tnf 1 Gene (Signaling Pathway Gene)", + "output": "89Zr-MMOT0530A (Radioimmunoconjugates)" + }, + { + "input": "Definition: something described as happening at least once during a week.\nConcepts: cellobiose permease activity (Molecular Function)\tAt least once a week (Frequencies)\tcolony-form units/milliliter (Unit of Arbitrary Substance Concentration)\tSarcomere (Cellular Structures)\tnegative regulation of telium development (Biologic Function)", + "output": "At least once a week (Frequencies)" + }, + { + "input": "Definition: alcohol use test described as questionnaire designed to test drinking problem\nConcepts: regulation of gamma-delta T-cell proliferation (regulation of T cell proliferation)\tTemptation and Restraint Inventory (Intellectual Product)\tacepromazine (A [Preparations])\tXq21.33-q23 (Chromosome band)\thepoxilin metabolic process (unsaturated fatty acid metabolic process)", + "output": "Temptation and Restraint Inventory (Intellectual Product)" + }, + { + "input": "Definition: something described as this gene plays a role in both transcriptional regulation and RNA interference.\nConcepts: Retinoblastoma cT2b TNM Finding v7 (Retinoblastoma cT2 TNM Finding v7)\tComprehensive Pulmonary Disorder Gene Deletion/Duplication Panel Reagents (Medical Device)\tNfdA (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tclostridium organisms (Clostridiaceae)\tSTAPHYLOCOCCAL NUCLEASE DOMAIN- AND TUDOR DOMAIN-CONTAINING PROTEIN 1 (Transcription Regulation Gene)", + "output": "STAPHYLOCOCCAL NUCLEASE DOMAIN- AND TUDOR DOMAIN-CONTAINING PROTEIN 1 (Transcription Regulation Gene)" + }, + { + "input": "Definition: Ear structure described as portion of the ear between the tympanic membrane and the cochlea, containing the tympanic cavity and its bones, the malleus, incus, and stapes.\nConcepts: Stage IA3 Lung Cancer (Stage I Lung Cancer AJCC v8)\tpsychological suppression (Repression, Psychology)\torthopedic surgery (Specialties, Surgical)\tMiddle ear (middle ear)\tdown-regulation of trophoblast cell migration (negative regulation of developmental process)", + "output": "Middle ear (middle ear)" + }, + { + "input": "Definition: Intellectual Product described as columbia-Suicidality Severity Rating Scale Baseline/Screening Version Phase 1 Study 1/14/09 (C-SSRS Baseline/Screening Version Phase 1 Study 1/14/09) How many times have you had these thoughts? (Lifetime).\nConcepts: GUT-ASSOCIATED LYMPHOID TISSUE (DIGESTIVE SYSTEM: GENERAL TERMS)\tCSS03-Most Severe Idea, Frequency-Life (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tCatalog (reference work)\tulcer; bowel, intestine, marginal (Ulcer)\tHealth Knowledge & Behavior (Intellectual Product)", + "output": "CSS03-Most Severe Idea, Frequency-Life (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)" + }, + { + "input": "Definition: something described as an inpatient encounter for short-term treatment of a severe injury or episode of illness, or other urgent medical condition.\nConcepts: FUNGI - MYCETAE (Eukaryota)\tMycobacterium diphtheriae (Corynebacterium species)\tInpatient Acute Care (Health Care Activity)\tprotein-pyridoxal-5-phosphate linkage (Molecular Function)\tregulation of conidiophore stalk development (regulation of conidiophore development)", + "output": "Inpatient Acute Care (Health Care Activity)" + }, + { + "input": "Definition: something described as a creatinine test system is a device intended to measure creatinine levels in plasma and urine. Creatinine measurements are used in the diagnosis and treatment of renal diseases, in monitoring renal dialysis, and as a calculation basis for measuring other urine analytes.\nConcepts: Treatment Cessation (patient care)\tvascular dementia multi-infarct (Dementia, Vascular)\tDEAFNESS, AUTOSOMAL RECESSIVE 39 (Rare Non-Neoplastic Disorder)\tcentral nervous system gray matter (CNS tissue)\tTEST, CYSTATIN C (Medical Device)", + "output": "TEST, CYSTATIN C (Medical Device)" + }, + { + "input": "Definition: something described as stage I is divided into stages IA and IB. In stage IA, the tumor is low-grade (likely to grow and spread slowly) and 5 centimeters or smaller. It may be either superficial (in subcutaneous tissue with no spread into connective tissue or muscle below) or deep (in the muscle and may be in connective or subcutaneous tissue).\nConcepts: Stage IA Soft Tissue Sarcoma AJCC v7 (Stage I Soft Tissue Sarcoma AJCC v7)\tAdrenal Cancer pN0 TNM Finding v7 (Finding)\tClonal Anergies (Immune Tolerance)\tUyghur Language (Turkic language)\tSchwann cell chemotaxis (cell chemotaxis)", + "output": "Stage IA Soft Tissue Sarcoma AJCC v7 (Stage I Soft Tissue Sarcoma AJCC v7)" + }, + { + "input": "Definition: something described as expanded Disability Rating Scale - Postacute Interview Caregiver Version (Expanded DRS-PI Caregiver Version) Does [s/he] require assistance from another person in tasks that require thinking abilities?\nConcepts: regulation of protein localisation to microtubule (Physiologic Function)\tC-SSRS Baseline/Screening Version Phase 1 Study - Active Suicidal Ideation with Any Methods (Not Plan) without Intent to Act (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tExpanded DRS-PI Caregiver Version - Require Assistance Thinking Tasks (Expanded DRS-PI Caregiver Version Questionnaire Question)\tcooking (Food Handling)\tsulfite:oxygen oxidoreductase activity (Molecular Function)", + "output": "Expanded DRS-PI Caregiver Version - Require Assistance Thinking Tasks (Expanded DRS-PI Caregiver Version Questionnaire Question)" + }, + { + "input": "Definition: Cell Component described as a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.\nConcepts: CD4 Lymphocytes Decreased, CTCAE (Investigations, CTCAE)\tpresynaptic active zone (Cell Component)\tFAC09901 (Peds-FACIT-F Questionnaire Question)\tmonoblasts count (Laboratory Procedure)\twart; senility (Keratoderma)", + "output": "presynaptic active zone (Cell Component)" + }, + { + "input": "Definition: EGF Family of Proteins described as an EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as a transmembrane protein which is cleaved by proteases to produce the secreted form of the protein which has specificity for the EGF RECEPTOR and the ERBB-4 RECEPTOR. The membrane-bound form of the protein has been identified as the receptor which binds to and allows DIPHTHERIA TOXIN to enter cells.\nConcepts: Bioconductor caAffy Contrasts Normalization (Statistical Technique)\tHeparin binding EGF like Growth Factor (EGF Family of Proteins)\tCentrifuges, Floor, Low-Speed (Centrifuges, Floor)\tUnresectable Osteosarcoma (Unresectable Sarcoma)\tLEC01-Combat/Exp to War-Zone: Witnessed (LEC-5 Standard Version Questionnaire Question)", + "output": "Heparin binding EGF like Growth Factor (EGF Family of Proteins)" + }, + { + "input": "Definition: Pharmacologic Substance described as an orally available antagonist of the glucocorticoid receptor (GR), with potential antineoplastic activity. Upon administration, relacorilant competitively binds to and blocks GRs. This inhibits the activity of GRs, and prevents both the translocation of the ligand-GR complexes to the nucleus and gene expression of GR-associated genes. This decreases the negative effects that result from excess levels of endogenous glucocorticoids, like those seen when tumors overproduce glucocorticoids. In addition, by binding to GRs and preventing their activity, inhibition with CORT125134 also inhibits the proliferation of GR-overexpressing cancer cells. GRs are overexpressed in certain tumor cell types and promote tumor cell proliferation.\nConcepts: Marker, Surrogate (Clinical Attribute)\tinterferon alfa-n1 (Interferon-alpha)\tmethanone, ((4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4aH-pyrazolo(3,4-g)isoquinolin-4a-yl)(4-(trifluoromethyl)-2-pyridinyl)- (Pharmacologic Substance)\t11p15.4 microduplication syndrome (Intellectual Disability)\tposterior pretectal nucleus (Pretectal region)", + "output": "methanone, ((4aR)-1-(4-fluorophenyl)-1,4,5,6,7,8-hexahydro-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4aH-pyrazolo(3,4-g)isoquinolin-4a-yl)(4-(trifluoromethyl)-2-pyridinyl)- (Pharmacologic Substance)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a blood vessel that is the terminal branch of the posterior inferior cerebellar artery supplying the inferior vermis.\nConcepts: MHV-JHM (Virus)\tHAMD2-Depressed Mood (HAMD 21 Questionnaire Question)\tNEISSERIA (Gram-negative coccus)\tTILORONE (Antineoplastic Agents)\tInferior Vermian Artery (Body Part, Organ, or Organ Component)", + "output": "Inferior Vermian Artery (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Absent epiphyses of the phalanges of the hand described as absence of one or more epiphyses of the 5th finger.\nConcepts: Abnormal reproductive system morphology (Anatomical Abnormality)\tActinium, NOS (Metals, Heavy)\tUsually Need Help from Another Person for Dressing and Grooming (Clinical or Research Assessment Answer)\tAbsent end part of little finger bone (Abnormality of the epiphyses of the 5th finger)\tcyclophosphamide/epirubicin/fluorouracil (Regimen Used to Treat Breast Carcinoma)", + "output": "Absent end part of little finger bone (Abnormality of the epiphyses of the 5th finger)" + }, + { + "input": "Definition: something described as the process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity.\nConcepts: infantile salaam (Central Nervous System)\tStage IVB Appendix Cancer (Stage IV Appendix Carcinoma AJCC v8)\tZNFN3A1 (Methyltransferase Gene)\tmodulation by virus of host protein phosphorylation (Biologic Function)\tsusceptibility to NK cell mediated cell killing (positive regulation of natural killer cell mediated cytotoxicity)", + "output": "susceptibility to NK cell mediated cell killing (positive regulation of natural killer cell mediated cytotoxicity)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as plasmids encoding COLICINS.\nConcepts: Cultural Competency (Anthropological Culture)\tlinoleic acid omega6-lipoxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tMedian Baseline Removal Method (Baseline Removal Method)\tPerphenazine [CNS] (1st Generation/Typical)\tFactor, Col (Biologically Active Substance)", + "output": "Factor, Col (Biologically Active Substance)" + }, + { + "input": "Definition: DataType described as a data type comprised of an integer or pointer that uniquely identifies an object.\nConcepts: Absent FHR Variability (Fetal heart rate variability - finding)\tSevere T-cell immunodeficiency (Cellular immunodeficiency)\tPrimary Treatment CAS Registry Number (Numbers)\tacetolactate synthase regulator activity (Molecular Function)\tObject Identifier Data Type (Intellectual Product)", + "output": "Object Identifier Data Type (Intellectual Product)" + }, + { + "input": "Definition: something described as a subjective score of 0 on a scale that ranges from 0: None to 10: The worst you can think of.\nConcepts: Nausea Score 0 (Nausea Scale)\tBlood culture analyzer, device (MISCELLANEOUS MEDICAL EQUIPMENT)\tregulation of timing of subpallium neuron differentiation (regulation of timing of neuron differentiation)\tWater Purification Systems, Reverse Osmosis, Hemodialysis, Mobile/Portable (Medical Device)\tent-pimara-9(11),15-diene synthase activity (carbon-oxygen lyase activity, acting on phosphates)", + "output": "Nausea Score 0 (Nausea Scale)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in transcription and may play a role in cell cycle progression.\nConcepts: Betula Pollen IgE Antibody RAST Score Measurement (Laboratory Procedure)\tPyruvate Kinase Isozyme M2 Measurement (Pyruvate kinase measurement)\tparafibromin (Transcription Regulation Gene)\tface flush (Pallor and flushing)\tThyroid Hormone Receptor alpha-1 (Amino Acid, Peptide, or Protein)", + "output": "parafibromin (Transcription Regulation Gene)" + }, + { + "input": "Definition: something described as the portion of the genome that is characterized by exon sequences, which represent the genetic template for the synthesis of proteins and other functional gene products.\nConcepts: KIAA0401 (TET3 gene)\tExome (Miscellaneous Molecular Biology Terms)\tST Elevated Myocardial Infarction (Myocardial Infarction)\tbenzo(a)anthracene (Hazardous or Poisonous Substance)\tAVL01TC (CDISC Functional Test Terminology)", + "output": "Exome (Miscellaneous Molecular Biology Terms)" + }, + { + "input": "Definition: Malignant neoplasm of retina described as a malignant neoplasm that has spread to the retina from another anatomic site.\nConcepts: Pulmono-ventricular junction (Zone of continuity)\tintercollicular gray (Body Part, Organ, or Organ Component)\tSensory perception (Esthesia)\tTubes, Esophageal, Decompression, Infant (Medical Device)\tMetastatic Tumor to the Retina (Neoplastic Process)", + "output": "Metastatic Tumor to the Retina (Neoplastic Process)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic dentin dysplasia disease with characteristics of extreme microdontia, oligodontia and abnormal tooth shape (including globular teeth, incisal notches and double tooth formation). Short roots with a variable pulp phenotype (including taurodontia and flame-shaped pulp) enamel hypoplasia and anterior open bite may also be associated. Caused by homozygous mutation in the SMOC2 gene on chromosome 6q27.\nConcepts: upregulation of cell organization (Cell Function)\tDentin dysplasia type 1 with microdontia and shape anomalies (Disease or Syndrome)\ttherapist (Professional Personnel)\tdruggist (Pharmacist)\tCATMTHID (Diagnostic Procedure)", + "output": "Dentin dysplasia type 1 with microdontia and shape anomalies (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as geriatric Depression Scale Short Form - Have you dropped many of your activities and interests?\nConcepts: Efalizumab product (Pharmacologic Substance)\tGDS02-Dropped Activities and Interests (Intellectual Product)\tMycoplasma pneumoniae (Microbiology procedure)\tAutologous Tumor Infiltrating Lymphocytes MDA-TIL (Cell)\tInflatable Bone Tamps (Medical Device)", + "output": "GDS02-Dropped Activities and Interests (Intellectual Product)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare genetic neurological disorder characterized by early-onset progressive ataxia associated with myoclonic seizures, generalized tonic-clonic seizures (which are often sleep-related) and normal to mild intellectual disability. Dysarthria, upward gaze palsy, sensory neuropathy, developmental delay and autistic disorder have also been associated.\nConcepts: PME type 5 - progressive myoclonic epilepsy type 5 (Myoclonic Epilepsies, Progressive)\tAbsent/small spleen (Abnormal spleen morphology)\tBaths (Electromechanical Devices)\tdefense response to other organism (Organism Function)\tHAMD-21 - Feelings of Guilt (Intellectual Product)", + "output": "PME type 5 - progressive myoclonic epilepsy type 5 (Myoclonic Epilepsies, Progressive)" + }, + { + "input": "Definition: Gene or Genome described as bone Morphogenetic Protein Genes (TGF Beta Superfamily) encode 9 structurally related Bone Morphogenetic Proteins, non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis.\nConcepts: CHINESE SYRIAN (Hamsters)\tSPMAGGLU (Laboratory Procedure)\tI need help in caring for myself (Findings-Based Question)\tC-SSRS Already Enrolled Subjects - Reasons For Most Severe Ideation (C-SSRS Already Enrolled Subjects Questionnaire Question)\tBone Morphogenetic Protein Gene (Transforming Growth Factor-Beta Family Gene)", + "output": "Bone Morphogenetic Protein Gene (Transforming Growth Factor-Beta Family Gene)" + }, + { + "input": "Definition: oxidoreductase complex described as a protein complex which is capable of superoxide dismutase activity.\nConcepts: Ragged cuticle (Nail abnormality)\tsuperoxide dismutase complex (oxidoreductase complex)\tMSK39 (NCAM1 gene)\thistory of life science (biology)\tarea 3 of Peele (Body Part, Organ, or Organ Component)", + "output": "superoxide dismutase complex (oxidoreductase complex)" + }, + { + "input": "Definition: something described as this SMQ is a sub-SMQ of Bradyarrhythmias (incl conduction defects and disorders of sinus node function) (SMQ), which is itself a sub-SMQ of Cardiac arrhythmia terms (incl bradyarrhythmias and tachyarrhythmias) (SMQ). For detailed description, please refer to the one in Cardiac arrhythmias (SMQ).\nConcepts: (R)-malate hydro-lyase activity (Molecular Function)\tresponse to butyrate (response to fatty acid)\tDisorders of sinus node function (Classification)\troof plate (Body Part, Organ, or Organ Component)\tEC 3.5.4.- (Amino Acid, Peptide, or Protein)", + "output": "Disorders of sinus node function (Classification)" + }, + { + "input": "Definition: Experimental Model of Disease described as the use of special strains of mice to study a human disease or condition, and how to prevent and treat it.\nConcepts: Mouse Model (Rodent Model of Disease)\tStage 0 Oropharyngeal Throat Cancer (Malignant neoplasm of mouth)\tApical-Like Protein (Regulatory Protein)\tNeonatal bilateral asymmetric myoclonic seizure (Disease or Syndrome)\tsporopollenin biosynthesis (aromatic compound biosynthetic process)", + "output": "Mouse Model (Rodent Model of Disease)" + }, + { + "input": "Definition: something described as actions performed to provide advice or instruction by a respiratory therapist\nConcepts: Bag (ParameterizedDataType - CodeSystem)\tDefinedStudyAgentTransfer (Defined Clinical Study Activity)\tKYMOGR RADIOGR (Radiographic imaging procedure)\tRespiratory Therapist Service (Professional/Ancillary Services)\tZFP42 gene (Transcription Regulation Gene)", + "output": "Respiratory Therapist Service (Professional/Ancillary Services)" + }, + { + "input": "Definition: Biologically Active Substance described as promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.\nConcepts: Person.initials (Initial)\tSuspension for injection in multidose container (Dosage Form and Package Type)\tSpecificity Protein 1 Transcription Factor (Amino Acid, Peptide, or Protein)\tHuman Chorionic Gonadotropin Measurement (Laboratory Procedure)\tEsophagus and Esophagogastric Junction Cancer pT4b TNM Finding v7 (Finding)", + "output": "Specificity Protein 1 Transcription Factor (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: O-acyltransferase activity described as catalysis of the reaction: sn-3-D-galactosyl-sn-2-acylglycerol + acyl-[acyl-carrier protein] = D-galactosyldiacylglycerol + [acyl-carrier protein].\nConcepts: Magnesium sulphate (magnesium)\tgp100 Adenovirus Vaccine (Immunologic Factor)\tJAK-2 c.1848 1849delTGinsCT (Cell or Molecular Dysfunction)\tacyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity (O-acyltransferase activity)\tProteobacteria delta subdivision (Bacterium)", + "output": "acyl-acyl-carrier-protein:D-galactosylacylglycerol O-acyltransferase activity (O-acyltransferase activity)" + }, + { + "input": "Definition: Protein Complex Subunit Gene described as this gene plays a role in immunity/defense.\nConcepts: RLF wt Allele (RLF gene)\tcellular response to adenine starvation (Cell Function)\tCD247 antigen (Gene or Genome)\tCXCR4 inhibitor POL6326 (Pharmacologic Substance)\tarea 7 of Brodmann (Body Location or Region)", + "output": "CD247 antigen (Gene or Genome)" + }, + { + "input": "Definition: something described as a specialized, self-renewing cell in the bone marrow that has the capacity to differentiate into a cell with a particular function.\nConcepts: amphiphilicity (chemical properties)\tE/A skrn'g nvrnmntl chem.bl (Laboratory Procedure)\tMultipotent Bone Marrow Stem Cell (Cell)\textraorganismal space (Cell Component)\tEndoplasmic Reticulum Degradation Pathway (Degradation Pathway)", + "output": "Multipotent Bone Marrow Stem Cell (Cell)" + }, + { + "input": "Definition: Population Database described as an archive that stores a wide variety of specific information on cancer patients that can later be leveraged and analyzed by researchers to identify health disparity trends in cancer incidence, mortality and patient survival, and/or that can be submitted to a central repository for similar purposes. EXAMPLE(S): Alaska Native Tumor Registry, Utah Cancer Registry OTHER NAME(S): NOTE(S):\nConcepts: Lymphocyte-Associated Receptor of Death (Receptor)\tcancer registries (Intellectual Product)\tStage III Cutaneous (Skin) Melanoma (Cutaneous Melanoma by AJCC v7 Stage)\tEccrine angiomatous hamartoma (Eccrine Sweat Gland Hamartoma)\tTubulointerstitial Nephritis Antigen-Related Protein (Regulatory Protein)", + "output": "cancer registries (Intellectual Product)" + }, + { + "input": "Definition: lactate biosynthetic process described as the chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde.\nConcepts: Biocompatibility Problem (Device Ingredient or Reagent Problem)\tD-lactate synthesis from methylglyoxal via (R)-lactaldehyde (methylglyoxal catabolic process to lactate)\tIndian Ocean Islands (Islands)\tPHQ0307A (PHQ Screener Version Questionnaire Question)\tSecond finger ulnar deviation (Hand)", + "output": "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde (methylglyoxal catabolic process to lactate)" + }, + { + "input": "Definition: Pharmacologic Substance described as a butyrophenone that has been investigated for antineoplastic activity.\nConcepts: 1-Butanone, 1-(4-fluorophenyl)-4-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidi nyl]- (Pharmacologic Substance)\tpositive regulation of long-chain fatty acid import into cell (positive regulation of fatty acid transport)\tMicromelic Dwarfism With Vertebral and Metaphyseal Abnormalities and Advanced Carpotarsal Ossification Gene (Gene or Genome)\tArtery Diseases, Carotid (Central nervous system vascular disorders NEC)\tSafety Tracking Document (Document type)", + "output": "1-Butanone, 1-(4-fluorophenyl)-4-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidi nyl]- (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O.\nConcepts: Go, Ichi, Ni and San complex (Cell Component)\t7-deoxyloganin,NADPH:oxygen oxidoreductase (Molecular Function)\tWD7-Problem Living with Dignity (Intellectual Product)\tLogotherapy (Psychotherapy Procedures)\tNSAA104 (NSAA Clinical Classification Question)", + "output": "7-deoxyloganin,NADPH:oxygen oxidoreductase (Molecular Function)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation.\nConcepts: FD Summary (Intellectual Product)\trhi (Body Location or Region)\tSpontaneous pain sensation (Abnormality of pain sensation)\tacids chain fatty long (Dietary Fatty Acid)\tresponse to pheromone regulating pheromone-induced unidirectional conjugation (response to pheromone)", + "output": "response to pheromone regulating pheromone-induced unidirectional conjugation (response to pheromone)" + }, + { + "input": "Definition: something described as human BCL9L wild-type allele is located in the vicinity of 11q23.3 and is approximately 32 kb in length. This allele, which encodes B-cell CLL/lymphoma 9-like protein, is involved in transcriptional activation.\nConcepts: primary meristem histogenesis (Organism Function)\tNon-specified HCPCS II external counter pulsation service reference code no charge (Tracking code use with or without ICD diagnosis)\tBiologically Based Therapy (Therapeutic or Preventive Procedure)\tWheal Size (Quantitative Concept)\tBCL9L wt Allele (BCL9L gene)", + "output": "BCL9L wt Allele (BCL9L gene)" + }, + { + "input": "Definition: protein-containing complex described as a heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome.\nConcepts: 20 (Natural Number)\tEpididymis Secretory Sperm Binding Protein Li 69p (Isomerase)\tpositive regulation of myofibroblast contraction (Cell Function)\tTERTIARY CARE CENTER (Hospitals)\tnascent polypeptide-associated complex location (Cell Component)", + "output": "nascent polypeptide-associated complex location (Cell Component)" + }, + { + "input": "Definition: something described as a question about whether an individual is or has been bothered by a change in weight.\nConcepts: Smoked Cigarettes Since Last Visit to This Clinic (Intellectual Product)\tRed Blood Cell Structure/Function/Metabolism (Biomedical Occupation or Discipline)\tChrysanthemum / ju hua (Plant)\tBothered by Change in Weight (Intellectual Product)\tIsoniazid Methanesulfonate (Antitubercular Agents)", + "output": "Bothered by Change in Weight (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as international Physical Activity Questionnaire (August 2002) - Short Last 7 Days Telephone Format - During the last 7 days, on how many days did you do moderate physical activities?\nConcepts: Acids, Sulfenic (Organic Chemical)\tANTIPARASITICS (Anti-Infective Agents)\tIPA01-Days Moderate Physical Activities (Intellectual Product)\tmitochondrial mRNA catabolic process (Genetic Function)\tInformatics, Public Health (Informatics)", + "output": "IPA01-Days Moderate Physical Activities (Intellectual Product)" + }, + { + "input": "Definition: something described as a protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes.\nConcepts: Visceral Crisis (Disease or Syndrome)\tCMG complex location (DNA replication preinitiation complex)\trepressor ecdysone receptor complex location (Cell Component)\tGleason Grade 3 (Gleason Grading System)\tStudySitePersonnel.telecomAddress (Intellectual Product)", + "output": "repressor ecdysone receptor complex location (Cell Component)" + }, + { + "input": "Definition: Pharmacologic Substance described as any substance used in the treatment of hypotension. A vasopressor agent increases reduced blood pressure.\nConcepts: Haemorrhage of vagina (Impaired circulatory system function)\tAgenesis of cerebellum and hydrocephalus syndrome (Genetic Diseases, X-Linked)\tVasoactive Agonists (Eye, ear, nose and throat preparation, NOS)\tAbnormal rectus muscle physiology (Abnormal extraocular muscle physiology)\troot cap mucilage anabolism (Molecular Function)", + "output": "Vasoactive Agonists (Eye, ear, nose and throat preparation, NOS)" + }, + { + "input": "Definition: something described as morphological and other aspects of diseases of the nervous system.\nConcepts: How Often Felt Nervous and Stressed in the Last Month (Intellectual Product)\tneuropathology disease (Pathologic Function)\tenzyme active site formation via S-phospho-L-cysteine (peptidyl-cysteine phosphorylation)\tGAS CHROMATOGR (Chemical procedure)\tLip and Oral Cavity Cancer pTis TNM Finding v6 (Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "neuropathology disease (Pathologic Function)" + }, + { + "input": "Definition: something described as an assessment of a wide range of cutaneous manifestations reflecting activity and damage from idiopathic inflammatory myopathy in children and adults.\nConcepts: Plant genetics (Occupation or Discipline)\t13-CRA (Retinoids for treatment of acne)\tCutaneous Assessment Tool (Symptom Specific Assessment Tool)\tautomobile accident (Phenomenon or Process)\tMaximal Expiratory Flow Volume Curves (Pulmonary Ventilation)", + "output": "Cutaneous Assessment Tool (Symptom Specific Assessment Tool)" + }, + { + "input": "Definition: Finding described as increased amplitude of the U wave, defined as an amplitude grerater than 1-2mm or 25 percent of the height of the T wave. []\nConcepts: Chelating agent (Qualitative Concept)\tProminent U wave (Finding)\thouttuynia (Family Davaineidae)\tscintillation counter (Medical Device)\tCleansing, Ethnic (Ethnic Violence)", + "output": "Prominent U wave (Finding)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as terminology associated with the Canadian Cardiovascular Society classification codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Extraordinary Opportunity: Molecular Targets of Prevention and Treatment (Extraordinary Opportunities for Investment)\tSalivary serous gland (Salivary gland part)\tregulation of CCL2 secretion (Cell Function)\tMILAT (Organism Attribute)\tCanadian Cardiovascular Society Classification (Intellectual Product)", + "output": "Canadian Cardiovascular Society Classification (Intellectual Product)" + }, + { + "input": "Definition: Professional or Occupational Group described as a person practiced in using computers, databases, and math to organize and analyze biological, medical, and health information.\nConcepts: Epididymis Secretory Protein Li 71 (Ubiquitin-Conjugating Enzymes)\tTARGETED GENOME SEQUENCING (Nucleic acid sequencing)\tCHO1 (KIF23 gene)\tBioinformatics Specialist (Professional or Occupational Group)\thistone H4-R3 demethylation (Molecular Function)", + "output": "Bioinformatics Specialist (Professional or Occupational Group)" + }, + { + "input": "Definition: Microanatomic Structure described as a region within a nucleic acid sequence that is specified using the microscopically visible transverse lines. These lines appear when differential staining techniques are applied to a metaphase chromosome. EXAMPLE(S): \"1q2.3-1q2.4\", where \"1\" indicates the chromosome, \"q\" indicates the arm, and the start and end bands are specified as \"2.3\" and \"2.4\" respectively OTHER NAME(S): NOTE(S):\nConcepts: Biopsy Procedure Kit/Trays (Procedure Kit/Trays)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(1;19)(q23;p13) PBX1/E2A (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)\tCytobandRange (Intellectual Product)\tIrinotecan/Panitumumab (Regimen Used to Treat Colorectal Carcinoma)\t2-halocarboxylic acid dehalogenase II activity (Molecular Function)", + "output": "CytobandRange (Intellectual Product)" + }, + { + "input": "Definition: actin cortical patch organization described as assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells.\nConcepts: Abnormality of the elbows (Anatomical Abnormality)\tactin cortical patch assembly (Cell Function)\tFlat-Coated Retriever (Sporting Breed)\tfunction joint (Joint function)\tU2 snRNP Auxiliary Factor Small Subunit Q157X (Cell or Molecular Dysfunction)", + "output": "actin cortical patch assembly (Cell Function)" + }, + { + "input": "Definition: Finding described as suspected seizures controlled with 1 anti-seizure drug (no recurrence within 3 days after treatment).\nConcepts: Antisense Oligonucleotide GTI-2040 (Antisense Oligonucleotides)\tGrade 2 Neonatal Convulsion (Finding)\tLee Lung Cancer 2011 Oncology Response Criteria (Tumor Response Criterion)\tFertilised ovum (Embryo)\tSprinkle Capsule Dosage Form (Biomedical or Dental Material)", + "output": "Grade 2 Neonatal Convulsion (Finding)" + }, + { + "input": "Definition: Neoplastic Process described as a basal cell carcinoma arising from the perianal skin. Local excision is the treatment of choice. Metastases are extremely rare.\nConcepts: Saccharomyces fermentati (Saito) Lodder & Kreger-van Rij 1952 (Candida)\tpeer influence (Social Behavior)\tAnal Margin Basal Cell Carcinoma (malignant neoplasm of anal margin)\tmicroRNA 27a (MicroRNA Gene)\tmalate-lactate transhydrogenase activity (oxidoreductase activity, acting on CH-OH group of donors)", + "output": "Anal Margin Basal Cell Carcinoma (malignant neoplasm of anal margin)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate or extent of tongue muscle cell differentiation.\nConcepts: independent (Finding)\tCHAPTER 2 DISEASES OF THE RESPIRATORY SYSTEM (PULMONARY DISORDERS: GENERAL)\tpositive regulation of tongue muscle cell differentiation (Cell Function)\tStanding flexion test (Flexion test)\tIntratubular erythrocyte cast (Finding)", + "output": "positive regulation of tongue muscle cell differentiation (Cell Function)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as management of symptoms and related conditions associated with an increase in body temperature resulting from thermoregulation dysfunction\nConcepts: Hyperthermia Treatment -- nursing care (Thermoregulation intervention)\tPower of isolated muscles and muscle groups (Organism Function)\tCongenital cerebral meningocele (Congenital malformation of the meninges)\tarteries anatomy (Body Part, Organ, or Organ Component)\tactivation of diorcinol biosynthesis (positive regulation of secondary metabolite biosynthetic process)", + "output": "Hyperthermia Treatment -- nursing care (Thermoregulation intervention)" + }, + { + "input": "Definition: multi-organism reproductive process described as the process in which a new plantlet develops from a meristem on the plant body. As part of this process, when the plantlet is large enough to live independently, the physical connection between the new plantlet and the main plant is severed.\nConcepts: Denture Base (Dentures and Denture Products)\tvegetative vivipary (multi-multicellular organism process)\tNutrition Physiologies, Animal (Organism Function)\tPQL1518 (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Child Questionnaire Question)\tpositive regulation of microtubule motor activity (regulation of microtubule motor activity)", + "output": "vegetative vivipary (multi-multicellular organism process)" + }, + { + "input": "Definition: Lymphohistiocytosis, Hemophagocytic described as hemophagocytic lymphohistiocytosis due to infections, autoimmune disorders, or underlying malignancies. Signs and symptoms include fever, lymphadenopathy, hepatomegaly, splenomegaly, and pancytopenia.\nConcepts: Rinsing/washing (Agent Administration)\tSecondary hemophagocytic lymphohistiocytosis (Disease or Syndrome)\tMitral E/A Ratio (Finding)\tGrade 4 Laryngeal Stenosis, CTCAE (Finding)\t367 MUROMEGALOVIRUS (Virus)", + "output": "Secondary hemophagocytic lymphohistiocytosis (Disease or Syndrome)" + }, + { + "input": "Definition: something described as specifies whether the adverse event or reaction term is a major concern or reason for reporting the adverse event. EXAMPLE(S): OTHER NAME(S): NOTE(S):\nConcepts: Respiratory Distress Syndromes (Disease or Syndrome)\tfamily with sequence similarity 49, member B (Gene or Genome)\tBCA-1 (Amino Acid, Peptide, or Protein)\tAbility to Go Up and Down Stairs at a Normal Pace (Clinical or Research Assessment Question)\tAdverse Event Highlighted Indicator (Highlighted Indicator)", + "output": "Adverse Event Highlighted Indicator (Highlighted Indicator)" + }, + { + "input": "Definition: Molecular Biology Research Technique described as a type of high-throughput, multiplex PCR method that uses a single pair of PCR primers to amplify multiple targets and to determine changes in complex genomes.\nConcepts: MIR196A1 wt Allele (Gene or Genome)\tMULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION (Polymerase Chain Reaction)\tDREAM Complex (Amino Acid, Peptide, or Protein)\tAIDS, Infant Mortality (Research Activity)\tMethylphenylethylhydantoin (M [Preparations])", + "output": "MULTIPLEX LIGATION-DEPENDENT PROBE AMPLIFICATION (Polymerase Chain Reaction)" + }, + { + "input": "Definition: Intellectual Product described as emotion Recognition - Total number of stimuli (face images) for which the participant's response was incorrect.\nConcepts: Placental Villous Dysmaturity (Finding)\tERT - Total Stimuli Response Incorrect (Intellectual Product)\tRefractory Thyroid Gland Hurthle Cell Carcinoma (Neoplastic Process)\tDefinedOptionRelationship.priorityNumber (Priority Number)\teflornithine HCl (Ornithine Decarboxylase Inhibitors)", + "output": "ERT - Total Stimuli Response Incorrect (Intellectual Product)" + }, + { + "input": "Definition: Mexican State described as a state in south eastern Mexico on the Yucatan Peninsula. Its capital is San Francisco de Campeche.\nConcepts: Free and Sovereign State of Campeche (Geographic Area)\ttenia solium (Class Cestoda)\tCraig Handicap Assessment and Reporting Technique - Short Form Interview Version Questionnaire Test Code (Intellectual Product)\tState Machine (algorithm)\tmelatonin metabolism (Molecular Function)", + "output": "Free and Sovereign State of Campeche (Geographic Area)" + }, + { + "input": "Definition: Finding described as <500-200/mm3; <0.5-0.2 x 10e9/L\nConcepts: Grade 2 Malabsorption (Finding)\tAntibody Production (Immune System Phenomena)\tEpidemiology, Race/Ethnic Origin (Functional Concept)\tLADIRUBICIN (Antibiotic)\tGrade 3 Lymphocyte count decreased (Lymphocyte Count Decreased, CTCAE 5)", + "output": "Grade 3 Lymphocyte count decreased (Lymphocyte Count Decreased, CTCAE 5)" + }, + { + "input": "Definition: something described as an abnormally increased width of the cranial fontanelles and sutures.\nConcepts: Vena media superficialis cerebri (Tributary of cavernous sinus)\tWidely patent fontanels and sutures (Large fontanelle)\tcardiac neural crest cell delamination involved in outflow tract morphogenesis (Cell Function)\tadrenarche (Puberty)\tGrade 2 Immune system disorders - Other, specify (Immune System Disorders - Other, Specify, CTCAE)", + "output": "Widely patent fontanels and sutures (Large fontanelle)" + }, + { + "input": "Definition: Pediatrics described as a branch of neurology that focuses on diseases of children.\nConcepts: DRRI1-D: Search/Disarm Potential Enemy (Intellectual Product)\tATIC-ALK Fusion Gene (Gene or Genome)\tPediatric Neurology (Neurology speciality)\tUTERINE CERVIX (Body Part, Organ, or Organ Component)\tubiquitin-dependent protein binding (Molecular Function)", + "output": "Pediatric Neurology (Neurology speciality)" + }, + { + "input": "Definition: something described as human WAS wild-type allele is located within Xp11.4-p11.21 and is approximately 8 kb in length. This allele, which encodes Wiskott-Aldrich syndrome protein, plays a role in actin cytoskeletal organization. Mutations in this gene are the cause of Wiskott-Aldrich syndrome an X-linked disease characterized by eczema, immune deficiencies and thrombocytopenia.\nConcepts: WASP (WAS gene)\tTricuspid Valve Regurgitant Jet Area (Cardiovascular finding)\tMucors (Mucorales)\tMuscle fiber (Myogenesis)\tEJACULATION RETROGRADE (Male sexual finding)", + "output": "WASP (WAS gene)" + }, + { + "input": "Definition: Excision of pelvis described as surgery to remove part or all of the fallopian tube(s).\nConcepts: Spiny Cocklebur (Plant)\tBack (Chest Pain)\tFallopian tube excision (Removal of ligature from fallopian tube)\tConstipated (Intestinal Diseases)\tPhosphorylations, Photosynthetic (Photosynthesis)", + "output": "Fallopian tube excision (Removal of ligature from fallopian tube)" + }, + { + "input": "Definition: something described as an indicator of the conclusion of a clinical event in relation to a specific point in time.\nConcepts: up-regulation of root hair elongation (positive regulation of plant epidermal cell differentiation)\tFANCD1 Gene Mutation (Fanconi Anemia Complementation Group Gene Mutation)\tindoxyl-UDPG glucosyltransferase activity (Molecular Function)\tJAK2 inhibitor BMS-911543 (Antineoplastic Enzyme Inhibitor)\tCEENRTPT (End Relative to Reference Period)", + "output": "CEENRTPT (End Relative to Reference Period)" + }, + { + "input": "Definition: Protein Cleavage Reagent described as a protein cleavage reagent comprised of the serine proteinase chymotrypsin that cleaves proteins into peptides at the C-terminal side of a phenylalanine, tyrosine, tryptophan or leucine residue unless that residue is followed by a proline.\nConcepts: Presbycusis, unspecified ear (Sensorineural Hearing Loss)\tpositive regulation of chromatin assembly/disassembly (regulation of chromatin assembly or disassembly)\tregulation of Ral protein signal transduction (regulation of Ras protein signal transduction)\tChymotrypsin Protein Cleavage Reagent (Indicator, Reagent, or Diagnostic Aid)\tScottish deerhound (Dog family)", + "output": "Chymotrypsin Protein Cleavage Reagent (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Bacterium described as a species of facultatively anaerobic, Gram-negative, rod shaped bacteria assigned to the phylum Proteobacteria. This species is non-spore forming, non-encapsulated, oxidase and indole negative, catalase positive, reduces nitrates, hydrolyzes urea, but not esculin and is motile using a peritrichous flagella however, some strains can be nonmotile. B. aquatica is found in water and small mammals and is pathogenic to humans.\nConcepts: negative regulation of IL-3 production (regulation of interleukin-3 production)\tBudvicia aquatica Aldov et al. 1985 (Bacterium)\tPI3K inhibitor GDC-0084 (Phosphatidylinositide 3-Kinase Inhibitor)\tFerula foetida (Bunge) Regel (Plant)\tTechnetium Tc-99m Pentetate (technetium 99m)", + "output": "Budvicia aquatica Aldov et al. 1985 (Bacterium)" + }, + { + "input": "Definition: Acetates described as the acetate salt form of potassium, an essential macromineral. Potassium maintains intracellular tonicity, is required for nerve conduction, cardiac, skeletal and smooth muscle contraction, production of energy, the synthesis of nucleic acids, maintenance of blood pressure and normal renal function. This agent has potential antihypertensive effects and when taken as a nutritional supplement may prevent hypokalemia.\nConcepts: Pseudo-obstruction intestine (Autonomic nervous system disorders)\tTables, Downflow (Manufactured Object)\tCase Comprehensive Cancer Center (NCI-Designated Comprehensive Cancer Center)\tAcetate, Potassium (P [Preparations])\tMETBRESP (Disease Response)", + "output": "Acetate, Potassium (P [Preparations])" + }, + { + "input": "Definition: Structure of ossicular muscle described as one of the muscles of the middle ear, and the smallest muscle in the body, which takes its origin from the wall of the pyramidal eminence on the posterior wall of the tympanic cavity, and inserts on the posterior surface of the neck of the stapes; it functions to dampen excessive sound vibrations.\nConcepts: Achilles tendon calcifications (Abnormality of the Achilles tendon)\tM. stapedius (Muscle of the Tympanum)\tNumber of Events (Quantitative Concept)\tFamily History Domain (Domain)\tEctopic thyroid gland (Thyroid Dysgenesis)", + "output": "M. stapedius (Muscle of the Tympanum)" + }, + { + "input": "Definition: Health Personnel described as physicians or other qualified individuals responsible for implementing and overseeing the policies and procedures followed by a health care facility to reduce the risk of infection to patients and staff.\nConcepts: Practitioner, Infection Control (Health Personnel)\tinitial mitotic spindle pole body separation (Cell Function)\tSignal Transduction, Light (Ocular Physiological Processes)\tPedsQL Neuromuscular Module Version 3.0 Parent Report for Child - Hard to Breathe (Intellectual Product)\tTotal Scale Score (Research or Clinical Assessment Tool)", + "output": "Practitioner, Infection Control (Health Personnel)" + }, + { + "input": "Definition: Medical Device described as a manual surgical instrument for general use is a nonpowered, hand-held, or hand-manipulated device, either reusable or disposable, intended to be used in various general surgical procedures. The device includes the applicator, clip applier, biopsy brush, manual dermabrasion brush, scrub brush, cannula, ligature carrier, chisel, clamp, contractor, curette, cutter, dissector, elevator, skin graft expander, file, forceps, gouge, instrument guide, needle guide, hammer, hemostat, amputation hook, ligature passing and knot-tying instrument, knife, blood lancet, mallet, disposable or reusable aspiration and injection needle, disposable or reusable suturing needle, osteotome, pliers, rasp, retainer, retractor, saw, scalpel blade, scalpel handle, one-piece scalpel, snare, spatula, stapler, disposable or reusable stripper, stylet, suturing apparatus for the stomach and intestine, measuring tape, and calipers. A surgical instrument that has specialized uses in a specific medical specialty is classified in separate regulations in Parts 868 through 892.\nConcepts: regulation of cell adhesion involved in sprouting angiogenesis (Cell Function)\tELTM (Temporal Concept)\tMallets (Reusable Devices)\tPathologic Stage IIA Neuroendocrine Carcinoma of the Skin AJCC v8 (Stage II Merkel Cell Carcinoma AJCC v7)\tAutologous EGFR806 Specific CAR T Cells (therapeutic autologous lymphocytes)", + "output": "Mallets (Reusable Devices)" + }, + { + "input": "Definition: something described as stage IV includes: (Any T, N1, M0, Any G); (Any T, Any N, M1, Any G). N1: Regional lymph node metastasis. M0: No distant metastasis. M1: Distant metastasis.\nConcepts: Pistil (Plant)\tStage IV Soft Tissue Sarcoma of the Trunk and Extremities (Neoplastic Process)\tVFQ2-Difficulty Shaving or Styling Hair (VFQ25-Self Administered Format Questionnaire Question)\tProbable Protein E4 (Papillomavirus Protein E4)\tspermium (Definitive germ cell)", + "output": "Stage IV Soft Tissue Sarcoma of the Trunk and Extremities (Neoplastic Process)" + }, + { + "input": "Definition: Medical Device described as bacteria culture media that include a solidifying agent derived from red seaweeds (i.e., agar) and that are available in ready-to-use bottles. These media may need supplementation with other reagents before use.\nConcepts: IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Bottle, Agar (Medical Device)\turoporphyrinogen III decarboxylase activity (carboxy-lyase activity)\tSIQ0105 (Intellectual Product)\tDevice Reprocessed Code (Reprocessed Code)\tCAST (Biospecimen)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Culture Media, Bottle, Agar (Medical Device)" + }, + { + "input": "Definition: plasma membrane protein complex described as a protein complex that consists of an alpha2-beta1 integrin complex bound to the cartilage matrix protein chondroadherin.\nConcepts: alpha2-beta1 integrin-chondroadherin complex location (Cell Component)\tAnaplasma species (Bacterium)\tEthmoidal Artery (Structure of artery of head, neck AND/OR brain)\tSNCB protein, human (Amino Acid, Peptide, or Protein)\tLaboratory Refrigerators (Manufactured Object)", + "output": "alpha2-beta1 integrin-chondroadherin complex location (Cell Component)" + }, + { + "input": "Definition: something described as subjective Opiate Withdrawal Scale - I am shaking.\nConcepts: CORYNEBACTERIUM SIMULANS (Bacterium)\tTEMPLE SYNDROME (Disease or Syndrome)\tClostridium oceanicum (Clostridium species g-p)\tOsteochondromuscular dystrophy (Inappropriate ADH Syndrome)\tSOWS Subjective (Handelsman) - I Am Shaking (SOWS Subjective Questionnaire Question)", + "output": "SOWS Subjective (Handelsman) - I Am Shaking (SOWS Subjective Questionnaire Question)" + }, + { + "input": "Definition: something described as the process in which a relatively unspecialized cell acquires specialized structural and/or functional features of a corticotropic hormone secreting cell. An corticotropic hormone secreting cell is a basophil cell of the anterior pituitary that produces corticotropin.\nConcepts: Oxygen reservoir cannula (Medical Device)\tADCS-ADL MCI - Perform Pastime, Hobby or Game: Fishing (ADCS-ADL MCI Questionnaire Question)\tMetal Artifact (CT Image Artifact)\tcorticotrophin hormone secreting cell differentiation (Cell Function)\tBoric acidum / boric acid (Pharmacologic Substance)", + "output": "corticotrophin hormone secreting cell differentiation (Cell Function)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as platelet-activating factor acetylhydrolase IB subunit beta (229 aa, ~26 kDa) is encoded by the human PAFAH1B2 gene. This protein is involved in the mediation of catabolism of platelet-activating factor.\nConcepts: CSS0524A (C-SSRS Already Enrolled Subjects Questionnaire Question)\tPAFAHB (Esterases)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, COL2A1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tCD4LY (Blood Cell Count Ratio Measurement)\tfemale gametophyte nucleus migration (Cell Function)", + "output": "PAFAHB (Esterases)" + }, + { + "input": "Definition: Professional or Occupational Group described as an emergency physician focuses on the immediate decision making and action necessary to prevent death or any further disability both in the pre-hospital setting by directing emergency medical technicians and in the emergency department. The emergency physician provides immediate recognition, evaluation, care, stabilization and disposition of a generally diversified population of adult and pediatric patients in response to acute illness and injury.\nConcepts: Never, Under Any Circumstances Leak Urine or Lose Bladder Control (Finding)\tUnable to Draw Blood (Finding)\tAllopathic & Osteopathic Physicians - Emergency Medicine (Professional or Occupational Group)\tPerceived Constipation (Constipation)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant, Ethosuximide (IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Anticonvulsant)", + "output": "Allopathic & Osteopathic Physicians - Emergency Medicine (Professional or Occupational Group)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as an insertion of the amino acid sequence asparagine-proline-histidine between the histidine at position 773 and the valine at position 774 of the epidermal growth factor receptor protein.\nConcepts: EGFR H773 V774insNPH (Cell or Molecular Dysfunction)\trostral orbital cortex (Body Part, Organ, or Organ Component)\tTSCYC - Upset When Reminded Bad Happened (TSCYC Questionnaire Question)\tRh-Hr Blood-Group System (Blood Group Antigens)\tMental health counseling individual each 15 minutes (mental health counseling)", + "output": "EGFR H773 V774insNPH (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Chest Pain described as an unpleasant sensation of tightness or pressure in the chest.\nConcepts: I am bothered by the change in my personality (Findings-Based Question)\tSoftware, Image Digitization System (Intellectual Product)\tBarrett Esophagus-Negative for Dysplasia (Barretts esophagus with dysplasia)\tHydrochloride, Rimantadine (Antiviral Agents)\tChest tightness of (Pain and Sensation Related to the Thoracic Organs)", + "output": "Chest tightness of (Pain and Sensation Related to the Thoracic Organs)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with double-stranded DNA containing a C/T mispair.\nConcepts: stomatal lineage progression (Cell Function)\tMaxillary Sinus Cancer pT3 TNM Finding v6 (Finding)\tUpper Limit of Quantitation (Numerical value)\tParotid gland carcinoma (Malignant tumour of parotid gland)\tthymine/cytosine mispair binding (mismatched DNA binding)", + "output": "thymine/cytosine mispair binding (mismatched DNA binding)" + }, + { + "input": "Definition: Laboratory Procedure described as a measurement of the Dohle bodies (blue-gray, basophilic, leukocyte inclusions located in the peripheral cytoplasm of neutrophils) in a biological specimen.\nConcepts: human population genetics (Occupation or Discipline)\tDRRI-2 - C: Not Have Adequate Shelter (Intellectual Product)\tDohle Bodies (Hematologic Tests)\tAbnormal HDL3c concentration (Finding)\tSafranine O (Tissue Stains)", + "output": "Dohle Bodies (Hematologic Tests)" + }, + { + "input": "Definition: something described as the target group that is chosen via a sampling methodology created to provide an equal probability of being chosen.\nConcepts: Burns second degree (Burn of skin of body region)\tUPD2-Clinical State on Meds (Intellectual Product)\trandom sample (Population Group)\tamputation procedure (removal technique)\tTSCYC - Arguing (Intellectual Product)", + "output": "random sample (Population Group)" + }, + { + "input": "Definition: Cell Component described as distinctive, unmyelinated axons produced by granule cells.\nConcepts: PerformedActivity (Component of Study Protocol)\tAbnormal renal morphology (Kidney)\tNanoimprinting (Non-Clinical Nanoparticle Application)\tBody-mind clearing each 15 minutes (Therapeutic or Preventive Procedure)\tdentate gyrus mossy fibre (Cell Component)", + "output": "dentate gyrus mossy fibre (Cell Component)" + }, + { + "input": "Definition: Gene or Genome described as a family of genes that is comprised of 13 nearly identical loci that are clustered in the vicinity of Xq24.\nConcepts: Lymphoid and Plasma Cell Tumour (Hematopoietic Neoplasms)\tEnglish race (Caucasians)\tRegulatoryAuthority.jurisdictionTerritoryCode (Intellectual Product)\tCancer/Testis Antigen Family 47 (Gene or Genome)\tregulation of telium development (Biologic Function)", + "output": "Cancer/Testis Antigen Family 47 (Gene or Genome)" + }, + { + "input": "Definition: something described as using an automated device to measure and/or evaluate a client's ability to contract his or her muscle(s) and exert force at a controlled speed in a particular region of his or her body. Service is billed per test.\nConcepts: Isokinetic testing one region each test (Electronic muscle testing)\tAbdomino-Perineal Rectum Excision (Therapeutic or Preventive Procedure)\tELECTROPHYSIOLOGY (Biophysics)\tEarly onset sarcoidosis (Disease or Syndrome)\tDetailed existing in-facility 30 minutes (Existing client in-facility with or without ICD diagnosis)", + "output": "Isokinetic testing one region each test (Electronic muscle testing)" + }, + { + "input": "Definition: Canine Neoplasm described as langerhans cell histiocytosis occurring in a dog.\nConcepts: GAIA Congenital Microcephaly Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)\tregulation of lateral attachment of mitotic spindle microtubules to kinetochore (Cell Function)\tCanine Langerhans Cell Histiocytosis (Canine Neoplasm)\tBCR-ABL1 E255V Mutation (Amino Acid, Peptide, or Protein)\tOsteoporosis/osteopenia (Classification)", + "output": "Canine Langerhans Cell Histiocytosis (Canine Neoplasm)" + }, + { + "input": "Definition: Gastrointestinal Hemorrhage described as bleeding originating in the retroperitoneal area.\nConcepts: HER2/Neu Positive by Immunohistochemistry 91-100 Percent (HER2/Neu Positive by Immunohistochemistry)\tPericanalicular fibroadenoma (Neoplasms, Fibroepithelial)\tPREGNANCY PARTNER (Population Group)\tmacimorelin (Medicinal product categorized by disposition)\tbleeding retroperitoneal (Disorder of retroperitoneal region, excluding major organs)", + "output": "bleeding retroperitoneal (Disorder of retroperitoneal region, excluding major organs)" + }, + { + "input": "Definition: Medical Device described as a uroporphyrin test system is a device intended to measure uroporphyrin in urine. Measurements obtained by this device are used in the diagnosis and treatment of porphyrias (primarily inherited diseases associated with disturbed porphyrin metabolism), lead poisoning, and other diseases characterized by alterations in the heme pathway.\nConcepts: MSRESCAT (Result Category)\tRelaxation abnormality (Cardiovascular finding)\tFertilized Egg (Embryo)\tTents, Laminaria (Pharmacologic Substance)\tFLUOROMETRIC, UROPORPHYRIN (Medical Device)", + "output": "FLUOROMETRIC, UROPORPHYRIN (Medical Device)" + }, + { + "input": "Definition: Finding described as prostate cancer in which the tumor is palpable and confined within the prostate.\nConcepts: Galloway syndrome (Hereditary disorder of nervous system)\tAVL0209 (Intellectual Product)\tEpithelioid sarcomas (Sarcoma, Epithelioid)\tProstate Carcinoma cT2 TNM Finding v8 (Finding)\tTakotsubo cardiomyopathy (Disease or Syndrome)", + "output": "Prostate Carcinoma cT2 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Finding described as the distance around an individual's chest.\nConcepts: anthocyanin 5-O-glucoside-4'''-O-malonyltransferase activity (Molecular Function)\tFACT-BMT Version 4 - Illness Is Hardship for My Family (FACT-BMT Version 4 Questionnaire Question)\tDoppler Ultrasonography, Pulsed (Imaging Techniques)\tChest Circumference (examination of chest)\tNanoparticle Paclitaxel (Organic Chemical)", + "output": "Chest Circumference (examination of chest)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a human monoclonal antibody directed against the human inhibitory killer IgG-like receptor (KIR) with potential immunostimulating and antineoplastic activities. Anti-KIR monoclonal antibody IPH 2101 binds to the KIR receptor expressed on human natural killer (NK) cells, which may prevent KIR-mediated inhibition of NK cells and permit NK cell-mediated anti-tumor cytotoxicity. KIRs are surface glycoproteins that bind to major histocompatibility complex (MHC)/human leukocyte antigen (HLA) class I subtypes on target cells; binding of KIRs inhibits NK cell-mediated cytotoxicity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78464\" active clinical trials using this agent.\nConcepts: regulation of system process (Biologic Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CYP3A5 (Medical Device)\t2OHOA (Antineoplastic Agents)\tIPH 2101 (Amino Acid, Peptide, or Protein)\tManometer (Medical Device)", + "output": "IPH 2101 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Palliative Care Version 1.0 test code.\nConcepts: Consolidated Budget Request (Intellectual Product)\tacetylcholine receptors (Muscle Tissue)\tquestionnaires hospital anxiety and depression scale (Assessment scales Ge-Iz)\tperception of virus (Antiviral Response)\tEuropean Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Palliative Care Version 1.0 Questionnaire Test Code (CDISC Questionnaire Terminology)", + "output": "European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Palliative Care Version 1.0 Questionnaire Test Code (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: something described as a chromosome band present on 13q\nConcepts: Porcine Lymphoma (Experimental Organism Neoplasm by Organism)\t1: 16228780-16196139 (Spatial Concept)\tUntreated Glioblastoma (Childhood Glioblastoma)\t13q14.2 (Cell Component)\tLung Cancer pM1 TNM Finding v8 (Finding)", + "output": "13q14.2 (Cell Component)" + }, + { + "input": "Definition: something described as the more ventral of two subdivisions of the agranular insula. Identified by multiple stains, it is found in the human ( Morel-2013 ) and the macaque ( Gallay-2012 ). The other is area Ia2.\nConcepts: Ia1 (Body Location or Region)\tKG (Population Group)\tFLJ11190 (TMEM74B gene)\tIntraperitoneal (Parenteral)\tVimentin Antibody (Immunologic Factor)", + "output": "Ia1 (Body Location or Region)" + }, + { + "input": "Definition: IVD Panels, Human Genetics, Metabolic Disorder, Epilepsy described as molecular assay reagents intended to identify mutations in genes associated with forms of epilepsy related to a metabolic disorder. Genetic variants at multiple loci have been associated with forms of epilepsy related to a metabolic disorder. These reagents are intended to detect mutations in multiple metabolic epilepsy-associated loci simultaneously.\nConcepts: Melanoma Cell Adhesion Molecule wt Allele (MCAM gene)\tEOR02-Have You Felt Weak (EORTC QLQ-C15-PAL Version 1 Questionnaire Question)\tMetabolic Epilepsy Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Epilepsy)\tFamily Percidae - perch (Suborder Percoidei)\tGlucosamine Phosphate Acetyltransferase (Acetyltransferase)", + "output": "Metabolic Epilepsy Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Metabolic Disorder, Epilepsy)" + }, + { + "input": "Definition: something described as a nucleotide comprised of either a purine or pyrimidine nitrogenous base bound to a deoxyribose sugar esterified with three phosphate groups. These molecules are essential for DNA synthesis.\nConcepts: CP-609754 (Farnesyl Transferase Inhibitor)\tExpanded Prostate Cancer Index Composite, Sexual Medications/Devices Supplement (Intellectual Product)\tPulmonary Aspergilloses, Invasive (Aspergillosis)\tDeoxyribonucleotide Triphosphate (Nucleic Acid, Nucleoside, or Nucleotide)\tAsthma COPD Overlap Syndrome (Disease or Syndrome)", + "output": "Deoxyribonucleotide Triphosphate (Nucleic Acid, Nucleoside, or Nucleotide)" + }, + { + "input": "Definition: Spinal nerve structure described as trunk of brachial nerve pelxus, each instance of which is formed by the anterior rami of some eight cervical and first thoracic spinal nerves; its anterior division becomes the medial cord of some plexus, and its posterior division helps form some posterior cord.\nConcepts: Covers, Clamp (Covers)\tCeliac disease (Disorder of small intestine)\tInfererior trunk of brachial plexus (Spinal nerve structure)\tHAQ0212 (HAQ-DI Without VAS Questionnaire Question)\tProduct containing beta-galactosidase (Enzyme)", + "output": "Infererior trunk of brachial plexus (Spinal nerve structure)" + }, + { + "input": "Definition: Adrenergic Agonists described as the hydrochloride salt form of dexmedetomidine, an imidazole derivate and active d-isomer of medetomidine with analgesic, anxiolytic and sedative activities. Dexmedetomidine selectively binds to and activates presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibits sympathetic activity, thereby leading to analgesia, sedation and anxiolysis.\nConcepts: dexmedetomidine (Analgesics)\tMutL, E. COLI, HOMOLOG OF, 1 (Gene or Genome)\tSurgical Shock (Postoperative Complications)\tComputed Tomography without Contrast (X-Ray Computed Tomography)\tHeart Leiomyosarcoma (Cardiac Sarcoma)", + "output": "dexmedetomidine (Analgesics)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as subdivision of respiratory system which consists of the nose, nasopharynx, oropharynx and larynx\nConcepts: ATP-dependent xenobiotic transmembrane transporter activity (ATPase-coupled transmembrane transporter activity)\tUpper respiratory tract structure (RESPIRATORY SYSTEM: GENERAL TERMS)\tPeriosteal osteosarcoma (Primary malignant neoplasm)\thypersensitivity reactions (acute inflammatory response to antigenic stimulus)\tFLJ35036 (ZBTB38 gene)", + "output": "Upper respiratory tract structure (RESPIRATORY SYSTEM: GENERAL TERMS)" + }, + { + "input": "Definition: something described as a non-metastasizing soft tissue neoplasm characterized by the presence of a neoplastic stroma containing spindle cells, dilated thin-walled vessels lined by fibrin, and a chronic inflammatory infiltrate. The majority of cases develop in the subcutaneous tissues usually in the lower extremities and present as slow growing masses. Recurrences occur in approximately half of the cases.\nConcepts: Time patient sent for (Temporal Concept)\tC-acetyltransferase activity (C-acyltransferase activity)\t5-FU/epi gel (Clinical Drug)\tPleomorphic hyalinising angiectatic neoplasm of soft parts (Neoplasm of uncertain behavior of soft tissues)\tDUX10 (Genes, Regulator)", + "output": "Pleomorphic hyalinising angiectatic neoplasm of soft parts (Neoplasm of uncertain behavior of soft tissues)" + }, + { + "input": "Definition: something described as extremely large amounts of data which require rapid and often complex computational analyses to reveal patterns, trends, and associations, relating to various facets of human and non-human entities.\nConcepts: Big Data (Information Systems)\tXMT1536 (Immunoconjugates)\taverantin formation (averantin metabolic process)\tPancreatic sarcoma (Malignant neoplasm of pancreas)\tROCK01-Time To Complete One Mile Walk (Intellectual Product)", + "output": "Big Data (Information Systems)" + }, + { + "input": "Definition: something described as a fusion gene that results from a chromosomal translocation t(3;12)(q26;p13) which exon 2 of the ETV6 gene with exon 2 of the MECOM gene. This rearrangement is associated with myeloproliferative disorders, myelodysplastic syndromes and acute myelogenous leukemia.\nConcepts: 10E6/uL (Unit of Number Concentration)\tETV6-MECOM Fusion Gene (Gene or Genome)\tCHILOMASTIX MESNILI (Chilomastix)\tOAB-q Short Form - Caused You Embarrassment (OAB-q Short Form Questionnaire Question)\tPastille (Basic Dosage Form Category)", + "output": "ETV6-MECOM Fusion Gene (Gene or Genome)" + }, + { + "input": "Definition: Rhythm of respiration described as an involuntary or voluntary pause in breathing, sometimes accompanied by loss of consciousness.\nConcepts: In-facility detailed new 45 minutes (Therapeutic or Preventive Procedure)\tAcquired Neurogenic Bladder (Disease or Syndrome)\tbreath holding (Respiration)\tLEC01-Other Stressful Event: Not Apply (LEC-5 Standard Version Questionnaire Question)\tK Homology Domain (RNA Recognition Motif)", + "output": "breath holding (Respiration)" + }, + { + "input": "Definition: cellular response to nitrosative stress described as any process in which a symbiont modulates the frequency, rate or extent of the production of nitric oxide as part of the innate immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Intraocular (Spatial Concept)\tMyeloid Cell Leukemia Sequence 1 (Amino Acid, Peptide, or Protein)\tMacroscopic Findings Specimen Condition (Qualitative Concept)\tmodulation by organism of defense-related host NO production (Organism Function)\tPA pressure - Pulmon art press (Feature of pulmonary arterial pressure)", + "output": "modulation by organism of defense-related host NO production (Organism Function)" + }, + { + "input": "Definition: cellular diagnosis, oropharyngeal cancer described as a non-keratinizing carcinoma arising from the oropharynx. It is characterized by the presence of large malignant cells with vesicular nuclei, prominent nucleoli, syncytial growth pattern, and a lymphoplasmacytic infiltrate. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68610\" active clinical trials using this agent.\nConcepts: leptin-mediated signalling pathway (cytokine-mediated signaling pathway)\tColon or Rectum Neuroendocrine Tumor Pathologic Regional Lymph Nodes TNM Finding v7 (Finding)\tOropharyngeal lymphoepithelioma (Malignant neoplasm of mouth)\tRed Tomato Juice (Food)\tether (Reagents)", + "output": "Oropharyngeal lymphoepithelioma (Malignant neoplasm of mouth)" + }, + { + "input": "Definition: something described as planned or occurring every evening.\nConcepts: Lipidemias (Finding)\tEsophageal Squamous Intraepithelial Neoplasia (Squamous intraepithelial lesion)\tEthnic groups (Ethnic group)\tCalculosis, NOS (Pathologic Function)\tEvery evening (Qualitative Concept)", + "output": "Every evening (Qualitative Concept)" + }, + { + "input": "Definition: Health Care Related Organization described as health product manufacturer\nConcepts: Mycobacterium abscessus (Moore and Frerichs 1953) Kusunoki and Ezaki 1992 emend. Leao et al. 2011 (Rapid growing mycobacteria)\tUmbilical cord cyst (Reproductive neoplasms female benign NEC)\tJohnson & Johnson Ltd (LIST OF PHARMACEUTICAL COMPANIES)\tBrushing your teeth (Clinical or Research Assessment Question)\tEtilefrin (E [Preparations])", + "output": "Johnson & Johnson Ltd (LIST OF PHARMACEUTICAL COMPANIES)" + }, + { + "input": "Definition: ECG Measurement described as the minimum time between the recording of a Q wave on ECG and the onset of the aortic blood pressure pulse.\nConcepts: regulation of maintenance of meiotic sister chromatin cohesion along arms (Cell Function)\tNKSF1 (Biologically Active Substance)\tMinimum QA Interval (ECG Measurement)\tER inheritance (endoplasmic reticulum organization)\tExistentialism (Philosophy)", + "output": "Minimum QA Interval (ECG Measurement)" + }, + { + "input": "Definition: Normal weight described as body mass index 5 percentile to less than 85 percentile\nConcepts: Normal weight in childhood (Finding)\tAcuity Card Grating Frequency (Quantitative Concept)\tNon-Neoplastic Finding (Other Finding)\tRecurrent Childhood Malignant Neoplasm (Recurrent Malignant Neoplasm)\tFACT-C Version 4 - I Feel Close to My Friends (Intellectual Product)", + "output": "Normal weight in childhood (Finding)" + }, + { + "input": "Definition: Thyroid Gland Follicular Adenoma described as a thyroid gland adenoma affecting predominantly children and adolescents. It is composed of branching papillary structures and follicles.\nConcepts: Megakaryocyte Count (Laboratory Procedure)\tPapillary Variant Thyroid Gland Follicular Adenoma (Neoplastic Process)\tantigen processing and presentation initiated by TLR mediated phagocytosis of antigen (antigen processing and presentation following phagocytosis)\tH2OSUPPR (Functional Concept)\tTAE (Therapeutic or Preventive Procedure)", + "output": "Papillary Variant Thyroid Gland Follicular Adenoma (Neoplastic Process)" + }, + { + "input": "Definition: kinase activity described as catalysis of the reaction: ATP + NADH = ADP + 2 H(+) + NADPH.\nConcepts: cullin 3 (Gene or Genome)\tQLES1-Been Interested in Your Work (Q-LES-Q Questionnaire Question)\treduced nicotinamide adenine dinucleotide kinase (phosphotransferase activity, alcohol group as acceptor)\tCD4+ NY-ESO-1-specific T Cells (Cell)\tPremature pubarche (Disorder of perineum)", + "output": "reduced nicotinamide adenine dinucleotide kinase (phosphotransferase activity, alcohol group as acceptor)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 36-item Version Interviewer-administered (WHODAS 2.0 36-item Version Interviewer-administered) In the past 30 days, how much difficulty did you have in: Starting and maintaining a conversation?\nConcepts: Inferior oblique muscle underaction (Finding)\tLysine N-Methyltransferase 6 (Amino Acid, Peptide, or Protein)\tCurtains, Cubicle, Reusable, Antimicrobial (Medical Device)\tAnterior chamber cleavage disorder (Disorder of anterior segment of eye)\tWD5-Starting/Maintaining Conversation (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)", + "output": "WD5-Starting/Maintaining Conversation (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)" + }, + { + "input": "Definition: Intellectual Product described as a coded value specifying the anatomic location that is the focus of the observation. EXAMPLE(S): Lower intestine for a colonoscopy observation OTHER NAME(S): NOTE(S): The target site of the result may be different than the target site of the activity (PerformedObservation) that generated it. For example, a chest x-ray (observation) has the target site of chest while the result might show an infiltration in the left lower lobe of the lung (target site of result), or a dermatological exam may check the skin across the whole body (target site of observation) while the result might identify a rash on the right leg (target site of result). Neither target anatomic site nor approach anatomic site is necessarily required or relevant for certain observations, however if either or both are present then the distinction between them is that the approach site is where the measurement or observation is performed and the target site is what is ultimately being evaluated. The target site is often implicit in the definition of the observation itself. Sources that capture anatomic site and laterality separately should map both to this attribute. For implementation models based on BRIDG where site and laterality are captured separately, you may wish to capture both concepts as a post-coordinated code structure or as multiple code repetitions\nConcepts: Dolphins (Toothed whale)\tPerformed Observation Target Anatomic Site Code (Intellectual Product)\tt(4;19)(q35;q13) (Cell or Molecular Dysfunction)\tmitochondrion DNA recombination (Recombination, Genetic)\tNEOPL UROL (Neoplastic Process)", + "output": "Performed Observation Target Anatomic Site Code (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a sex cord-stromal tumor that arises from the ovary or the testis. Representative examples include fibroma, fibrosarcoma, and thecoma.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, SERPINA1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tTransformational Leadership (Leadership)\tCarboplatin-Cyclophosphamide-Etoposide (Regimen Used to Treat Hodgkin Lymphoma)\tTumor of the Thecoma/Fibroma Group (Neoplastic Process)\tBiomechanics (Biomedical Occupation or Discipline)", + "output": "Tumor of the Thecoma/Fibroma Group (Neoplastic Process)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed.\nConcepts: MAOI - Isocarboxazid (Isoxazoles)\tFAMS01-Trouble Understanding Worsening (FAMS Questionnaire Question)\tSelf-Management: Known Allergy (Finding)\tGLAND, CLITORAL (Body Part, Organ, or Organ Component)\tskeletal muscle satellite cell fate determination (stem cell fate determination)", + "output": "skeletal muscle satellite cell fate determination (stem cell fate determination)" + }, + { + "input": "Definition: Malignant Female Reproductive System Neoplasm described as the reemergence of a malignant female reproductive system neoplasm after a period of remission.\nConcepts: undef.manl mscl tst narr req (Manual muscle testing)\tRecurrent Malignant Female Reproductive System Neoplasm (Malignant Female Reproductive System Neoplasm)\tLLOQ (Quantitative Concept)\tRepeating dressing (Common nursing interventions)\tHarderian gland (Non-human body structure)", + "output": "Recurrent Malignant Female Reproductive System Neoplasm (Malignant Female Reproductive System Neoplasm)" + }, + { + "input": "Definition: something described as removal of an autonomic or sensory ganglion by any means.\nConcepts: Tumor Suppressor p53 Arg273Ser (TP53 Protein Variant)\tProstatic Extramedullary Myeloid Neoplasm (Malignant neoplasm of prostate)\tGanglionectomies (Denervation)\tdownregulation of TRAIL-activated apoptotic signaling pathway (Molecular Function)\tElbow Therapeutic Orthoses (Orthoses, Upper Limb, Elbow)", + "output": "Ganglionectomies (Denervation)" + }, + { + "input": "Definition: something described as the series of events in which high humidity is detected and converted into a molecular signal.\nConcepts: (L/min)/kg (Volume per unit mass per unit time)\tdetection of high humidity (Cell Function)\tSite Management Communications and Tracking Subcategory (Document type)\tChondrosarcomas, Mesenchymal (Osseous AND/OR chondromatous neoplasm)\t1-18:2-2-18:1-phosphatidylcholine desaturase activity (oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water)", + "output": "detection of high humidity (Cell Function)" + }, + { + "input": "Definition: Membrane Microdomains described as small pit, depression, or invagination, such as any of the minute pits or incuppings of the cell membrane formed during pinocytosis, which close and then pinch off to form small, free, fluid filled vesicles or pinosomes in the cytoplasm.\nConcepts: Fenbenicillin (penicillins)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, ACADVL (Medical Device)\tCaveolas (Cell surface AND/OR associated structure)\tOropharyngeal (p16-Negative) Carcinoma pT3 TNM Finding v8 (Finding)\tEnglish Plantain Pollen IgG Measurement (Immunoglobulin measurement)", + "output": "Caveolas (Cell surface AND/OR associated structure)" + }, + { + "input": "Definition: Hafniaceae described as any bacteria that is not assigned to the species level but can be assigned to the Edwardsiella genus level.\nConcepts: Edwardsiella Ewing and McWhorter 1965 (Enterobacteriaceae)\tdental (Clinical NEC)\tBasil (Oils, Volatile)\tseptum nasal (Body part)\tMacular Dystrophy, Best (Disorders of choroid and retina)", + "output": "Edwardsiella Ewing and McWhorter 1965 (Enterobacteriaceae)" + }, + { + "input": "Definition: Virus described as a genus of the family POXVIRIDAE, subfamily CHORDOPOXVIRINAE, comprising many species infecting mammals. Viruses of this genus cause generalized infections and a rash in some hosts. The type species is VACCINIA VIRUS.\nConcepts: Orthopoxvirus (Virus)\tcharacteristicModifiedIndicator (Functional Concept)\tAnnual Reports as Topic (Intellectual Product)\tRespiratory, Rehabilitative & Restorative; Art Therapist (HealthcareProviderTaxonomyHIPAA - CodeSystem)\tEstimated total intake of monounsaturated fat in 24 hours (Quantitative Concept)", + "output": "Orthopoxvirus (Virus)" + }, + { + "input": "Definition: Diagnostic Techniques, Obstetrical and Gynecological described as methods used for the assessment of placental function.\nConcepts: VALTORCITABINE DIHYDROCHLORIDE (Pharmacologic Substance)\tVertebral Arch Pedicles (Body Part, Organ, or Organ Component)\tChest X-ray: pulmonary interstitial disease (Pulmonary)\tSphing-4-Enine 1-Phosphate (Sphingolipids)\tPlacental function test (Diagnostic Techniques, Obstetrical and Gynecological)", + "output": "Placental function test (Diagnostic Techniques, Obstetrical and Gynecological)" + }, + { + "input": "Definition: Occipital lobe described as a horizontal groove on the lateral aspect of the occipital lobe of human cerebral cortex. It separates the middle occipital gyrus into superior and inferior parts. In some cases it intersects the lunate sulcus of the human caudally ( Duvernoy-1992 ). Some authors regard the lunate sulcus to be part of the the lateral occipital sulcus ( Van Essen Lab-2002 ).\\r\\nEquivalent structures are not found in the macaque or in the smooth cerebral cortex of the rat and mouse ( NeuroNames ).\nConcepts: Lateral occipital sulcus (Cortex of occipital lobe)\tUrinary System Disorder (Genitourinary system)\tLimb girdle muscular dystrophy due to beta-sarcoglycan deficiency (Disease or Syndrome)\tOleates (Fatty Acids, Unsaturated)\tLEPR Protein (Receptor)", + "output": "Lateral occipital sulcus (Cortex of occipital lobe)" + }, + { + "input": "Definition: ADRENAL AND GONADAL HORMONES described as a 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation.\nConcepts: biotechnologies (technology/technique)\tcytokine inducible SH2-containing protein (Suppressor of Cytokine Signaling Family Gene)\tamiloride transport (nitrogen compound transport)\tASEX02-Reach Orgasm (Intellectual Product)\t3 alpha Hydroxy 5 beta Androstan 17 One (Hormone)", + "output": "3 alpha Hydroxy 5 beta Androstan 17 One (Hormone)" + }, + { + "input": "Definition: something described as contrast material enhancement of the pia mater or enhancement that extends into the subarachnoid spaces of the sulci and cisterns is leptomeningeal enhancement. Leptomeningeal enhancement is usually associated with meningitis, which may be bacterial, viral, or fungal. The primary mechanism of this enhancement is breakdown of the blood-brain barrier without angiogenesis.\nConcepts: Osteopathic manipulation, inhibitory pressure technique (Indirect Treatment)\tBiliary Stasis (Abnormality of the biliary system)\tLeptomeningeal enhancement (Abnormal meningeal morphology)\tDuodenoscopes (Endoscopes, Gastrointestinal)\timmunotoxin CMD-193 (Pharmacologic Substance)", + "output": "Leptomeningeal enhancement (Abnormal meningeal morphology)" + }, + { + "input": "Definition: negative regulation of transferase activity described as any process that stops, prevents or reduces the frequency, rate or extent of RNA polymerase III activity.\nConcepts: Autologous Dendritic Cell Adenovirus Type 5-Survivin Vaccine (Immunologic Factor)\tEGFR NP 005219.2:p.S768I (EGFR Protein Variant)\tnegative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter (negative regulation of transferase activity)\t4: 186122364-186051899 (Spatial Concept)\tFitzpatrick Skin Type II (Fitzpatrick Classification Scale)", + "output": "negative regulation of DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter (negative regulation of transferase activity)" + }, + { + "input": "Definition: regulation of glucose transmembrane transport described as any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: CSS0507A (Intellectual Product)\tnegative regulation of glucose transmembrane transport (regulation of glucose transmembrane transport)\tLeft lateral decubitus position (MUSCULOSKELETAL FUNCTIONS: GENERAL TERMS)\tBIRINAPANT (Amino Acid, Peptide, or Protein)\tAIDS/HIV neuropathy (HIV Infections)", + "output": "negative regulation of glucose transmembrane transport (regulation of glucose transmembrane transport)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a fiber tract of reptiles and birds that is probably homologous to the ansa lenticularis and field H2 of mammals ( Carpenter-1983, Crosby-1962 ).\nConcepts: Biologics licensing application (Intellectual Product)\tPUL02-Hands to Table From Lap (PUL 2.0 Functional Test Question)\tFagopyrii / qiao mai (Oriental herbs and natural substances letter F)\tNeurofibromin 2 Gene (Gene Mutation)\tbasal forebrain bundle (Body Part, Organ, or Organ Component)", + "output": "basal forebrain bundle (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Anatomical Abnormality described as an abnormality of the superior crus of the antihelix is the upper cartilaginous ridge arising at the bifurcation of the antihelix that ends beneath the fold of the ascending helix, and separates the concha from the triangular fossa.\nConcepts: Abnormality of posterior crus of antihelix (Anatomical Abnormality)\tAggregates (Spatial Distribution)\tANTISERUM, FLUORESCENT, C. DIPHTHERIAE (Indicator, Reagent, or Diagnostic Aid)\tC6orf134 (Gene or Genome)\tTAFII-15 (TAF12 Gene Product)", + "output": "Abnormality of posterior crus of antihelix (Anatomical Abnormality)" + }, + { + "input": "Definition: Biologically Active Substance described as cyclic AMP-responsive element-binding protein 5 (508 aa, ~57 kDa) is encoded by the human CREB5 gene. This protein is involved in transcriptional regulation.\nConcepts: Reduced O-mannosyl glycans on alpha-dystroglycan (MUSCLE SOFT, TISSUE)\tpositive regulation of motoneuron apoptosis (Cell Function)\tXIST Gene (Gene or Genome)\tIntraarticular Route of Administration (RouteBySite)\tcAMP Responsive Element Binding Protein 5 (Amino Acid, Peptide, or Protein)", + "output": "cAMP Responsive Element Binding Protein 5 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: TXLNA gene described as human TXLNA wild-type allele is located in the vicinity of 1p35.1 and is approximately 19 kb in length. This allele, which encodes alpha-taxilin protein, plays a role in the regulation of vesicle traffic.\nConcepts: vacuole, cell cycle-correlated morphology (storage vacuole)\tHigh fecal coproporphyrin 1 (Increased fecal porphyrin)\tN-(N-(N-(N(2)-L-Arginyl-L-Lysyl)-L-alpha-Aspartyl)-L-Valyl)-L-Tyrosine (Biologically Active Substance)\tTXLNA wt Allele (Gene or Genome)\tBiggest Problem (Phenomenon or Process)", + "output": "TXLNA wt Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as with respect to a drug, information derived from a clinical trial, an adverse event report, a post-approval study, or peer-reviewed biomedical literature; data derived from the post-market risk identification and analysis system (REMS); or other scientific data regarding: (a) a serious risk or unexpected serious risk associated with use of the drug since the drug was approved, since the REMS was required or last assessed (b) the effectiveness of the approved REMS for the drug obtained since the last assessment of such strategy.\nConcepts: new safety information (Information)\tAbnormal interventricular septum morphology (Heart Septal Defects)\tLymphatic System Therapeutic Procedure (Therapeutic procedure)\tFAP-specific CD8-positive T cells (Antineoplastic Immune Cell)\tEQUIPMENT, PHOTOGRAPHIC, FOR PHYSIOLOGIC FUNCTION MONITOR (Medical Device)", + "output": "new safety information (Information)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - In the opinion of the examiner, is a clinical evaluation or follow up warranted for possible pharmacotherapy of depression?\nConcepts: BD2-selective BET Inhibitor ABBV-744 (Organic Chemical)\tUHDR139 (UHDRS 1999 Version Clinical Classification Question)\tHOME, HOSPICE (hospice environment)\tlipoteichoic acid binding (Molecular Function)\tNCMH (Mesenchymal hamartoma)", + "output": "UHDR139 (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: something described as catalysis of the reaction: sn-glycerol 3-phosphate + UDP-D-galactose = 1-O-alpha-D-galactosyl-sn-glycerol 3-phosphate + H(+) + UDP.\nConcepts: aryl-aldehyde dehydrogenase (NAD) activity (aldehyde dehydrogenase (NAD+) activity)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, FAH (Medical Device)\tglycerol 3-phosphate 1alpha-galactosyltransferase activity (UDP-galactosyltransferase activity)\tfollicular mucinosis type mycosis fungoides (mycosis fungoides of skin)\tAbsent fingernails (ANONYCHIA)", + "output": "glycerol 3-phosphate 1alpha-galactosyltransferase activity (UDP-galactosyltransferase activity)" + }, + { + "input": "Definition: something described as columbia-Suicide Severity Rating Scale Lifetime/Recent Version (C-SSRS Lifetime/Recent Version) How many times have you had these thoughts? (Past 1 Month).\nConcepts: Osteocartilaginous Exostosis (Benign tumor of bone and articular cartilage)\tCYP27 Family (Enzyme)\tWeight increased (Weight gain)\tCSS11-Most Severe Idea, Frequency-P1M (Intellectual Product)\tCardiac output alteration (Finding)", + "output": "CSS11-Most Severe Idea, Frequency-P1M (Intellectual Product)" + }, + { + "input": "Definition: Neoplastic Process described as a polyp that arises from the surface of the cervix.\nConcepts: chitin anabolism (Molecular Function)\tIRB-IEC Subm (Intellectual Product)\tPolyp of the Uterine Cervix (Benign neoplasm of uterus)\tCD158e (receptor)\tregulation of maltoheptaose transport (regulation of heptasaccharide transport)", + "output": "Polyp of the Uterine Cervix (Benign neoplasm of uterus)" + }, + { + "input": "Definition: phosphotransferase activity, alcohol group as acceptor described as catalysis of the reaction: 2 D-glucose 1-phosphate = D-glucose + D-glucose 1,6-bisphosphate.\nConcepts: glucose 1-phosphate transphosphorylase activity (kinase activity)\tBrevibacterium casei (Bacterium)\tConsumer Health Informatics (Informatics)\treinsertion (Implantation procedure)\tWater Traps (Device Labeled for Single Use)", + "output": "glucose 1-phosphate transphosphorylase activity (kinase activity)" + }, + { + "input": "Definition: DRS Questionnaire Question described as disability Rating Scale - Motor response.\nConcepts: Dyskinesia (Classification)\tpositive regulation of protein localization to endosome (regulation of protein localization to endosome)\tpNGVL4a-CRT/E7(detox) DNA vaccine (Cancer Vaccines)\tAsterococcus hyorhinis (Mycoplasma)\tDRS01-Motor Response (Intellectual Product)", + "output": "DRS01-Motor Response (Intellectual Product)" + }, + { + "input": "Definition: something described as a collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers.\nConcepts: Alkyl-Guanine Transferase Inhibitor (Pharmacologic Substance)\tSmall intestine bacterial overgrowth breath test each test (Laboratory Procedure)\tIVD Test Reagent/Kits, Clinical Chemistry, Enzyme, Creatine Kinase, Isoenzyme (IVD Test Reagent/Kits, Clinical Chemistry, Enzyme)\tHISTOL TYPE NEOPL (Neoplastic Process)\tEar Pain (Pain of head and neck region)", + "output": "HISTOL TYPE NEOPL (Neoplastic Process)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: 24-methylenelophenol + O2 + NADH + H+ <=> 4alpha-hydroxymethyl-ergosta-7,24(241)-dien-3beta-ol + NAD + H2O.\nConcepts: 24-methylenelophenol methyl oxidase activity (Molecular Function)\taxon collateral (Axon)\tPVRGVOL (Quantitative Concept)\tLimitations in the use of hands or fingers, required the help of another person for all tasks (Finding)\tOAB-q Short Form - Locate Closest Restroom as Soon as You Arrive (Intellectual Product)", + "output": "24-methylenelophenol methyl oxidase activity (Molecular Function)" + }, + { + "input": "Definition: Urethral Anastomotic Leak, CTCAE described as asymptomatic diagnostic finding; intervention not indicated\nConcepts: Grade 1 Urethral Anastomotic Leak, CTCAE (Urethral Anastomotic Leak, CTCAE)\tIVD Test Reagent/Kits, Immunoassay, Standard, Neuroendocrine Hormone (Medical Device)\tDIPG (Neoplastic Process)\tsedoheptulose-bisphosphatase activity (phosphoric monoester hydrolase activity)\tEIEE19 (Disease or Syndrome)", + "output": "Grade 1 Urethral Anastomotic Leak, CTCAE (Urethral Anastomotic Leak, CTCAE)" + }, + { + "input": "Definition: something described as retrospective studies.\nConcepts: Level of Evidence III (Level of Evidence)\tBuckwheat Hull Garments (Reusable Devices)\tIncrease in tryptophan content of the diet compared to the assessed baseline intake of tryptophan for the individual. (Therapeutic or Preventive Procedure)\tBladder Carcinosarcoma (Infiltrating Bladder Urothelial Carcinoma)\tbenzene breakdown (benzene metabolic process)", + "output": "Level of Evidence III (Level of Evidence)" + }, + { + "input": "Definition: Intellectual Product described as child-Pugh Classification (Child-Pugh) Serum bilirubin, mg/dL.\nConcepts: Wilms tumor, epithelial predominant (Neoplastic Process)\tCLINICAL STUDY (Study)\tCPS0103 (Child-Pugh Clinical Classification Question)\tGrade 1 Arterial Injury, CTCAE (Arterial Injury, CTCAE)\tAtypical Adenomatous Hyperplasia (Pathologic Function)", + "output": "CPS0103 (Child-Pugh Clinical Classification Question)" + }, + { + "input": "Definition: Factor V deficiency described as an autosomal recessive, inherited coagulation disorder characterized by the partial or complete absence of factor V activity in the blood.\nConcepts: AC globulin deficiency (Blood Coagulation Disorders, Inherited)\tClinical ENSAT Staging Finding v7 (ENSAT Staging Finding v7)\tECTODERMAL DYSPLASIA ANHIDROTIC 03 (Ectodermal Dysplasia)\tOMORRESU (Quantitative Concept)\tTNF superfamily member 1 (tumor necrosis factor family gene)", + "output": "AC globulin deficiency (Blood Coagulation Disorders, Inherited)" + }, + { + "input": "Definition: CDISC Clinical Classification Terminology described as emory Treatment Resistance Interview for PTSD test code.\nConcepts: Oenothera biennis / evening primrose (Plant)\tVincristine Liposome Regimen (Regimen Used to Treat Acute Lymphoblastic Leukemia)\tEmory Treatment Resistance Interview for PTSD Clinical Classification Test Code (Intellectual Product)\tGrade 4 Vaginal Inflammation, CTCAE (Vaginal Inflammation, CTCAE)\tInclusion Cyst (Epithelial inclusion cyst)", + "output": "Emory Treatment Resistance Interview for PTSD Clinical Classification Test Code (Intellectual Product)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration.\nConcepts: Minimal Residual Disease Method (Methods)\tProtein L-Myc-1 (TRANSCRIPTION FACTOR)\tAphasmidia (Nematodes)\theteroduplex DNA loop binding (DNA secondary structure binding)\tIVD Test Reagent/Kits, Serology, Virus, Rotavirus, Antigen (Medical Device)", + "output": "heteroduplex DNA loop binding (DNA secondary structure binding)" + }, + { + "input": "Definition: Whole Blood Cell Test described as the number of RED BLOOD CELLS per unit volume in a sample of venous BLOOD.\nConcepts: PARACAVAL LYMPH NODE (Body Part, Organ, or Organ Component)\tErythrocyte Number (Whole Blood Cell Test)\tFrequency of Feeling Nervous (Clinical or Research Assessment Question)\tBone of tarsus (Bone structure of lower limb)\tGrade 3 Cholecystitis (Finding)", + "output": "Erythrocyte Number (Whole Blood Cell Test)" + }, + { + "input": "Definition: Structure of cranial nerve nucleus described as a collection of neurons of cranial nerve III located in the rostral half of the midbrain at the level of the superior colliculus, which contain somatic efferent motor neurons that innervate all the extraocular muscles except the superior oblique and lateral rectus.\nConcepts: Rickettsiaceae Pinkerton 1936 (Approved Lists 1980) emend. Brenner et al. 1993 (Gram-negative bacillus)\tOculomotorii, Nucleus Nervi (Midbrain nucleus)\tCareLex electronic Trial Master File Terminology (Terminology Subset)\tregulation of interferon-gamma secretion (regulation of interferon-gamma production)\tINFILTRATOR (Medical Device)", + "output": "Oculomotorii, Nucleus Nervi (Midbrain nucleus)" + }, + { + "input": "Definition: Antineoplastic Plant Product described as an extract derived from the mushroom Coriolus versicolor, containing polysaccharide K (PSK) and polysaccharide-peptide (PSP), with potential immunomodulating and antineoplastic activities. Coriolus versicolor extract has been shown to stimulate the production of lymphocytes and cytokines, such as interferons and interleukins, and may exhibit antioxidant activities. However, the precise mechanism of action(s) of this agent is unknown. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C78184\" active clinical trials using this agent.\nConcepts: HNPCC Gene Mutation (Cell or Molecular Dysfunction)\tPSEUDOMONAS ALCALIGENES (Pseudomonas, nonfluorescent group)\tFlemming body (cellular anatomical entity)\tCoriolus versicolor extract (Pharmacologic Substance)\tCytochrome P450 Family 8 Subfamily B Polypeptide 1 (Amino Acid, Peptide, or Protein)", + "output": "Coriolus versicolor extract (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as any process in which a symbiont modulates the frequency, rate or extent of systemic acquired resistance in the host organism; systemic acquired resistance is a salicylic acid-mediated response that confers broad spectrum systemic resistance. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: Conjugated Linoleic Acid n-7 (Conjugated Linoleic Acid)\tBladder Carcinoma TNM Finding v8 (Urinary Tract Cancer TNM Finding v8)\tStage 0 Colorectal (Colon or Rectal) Cancer (Neoplastic Process)\tmodulation by symbiont of host systemic acquired resistance (Organism Function)\tRHAMM protein, human (receptor)", + "output": "modulation by symbiont of host systemic acquired resistance (Organism Function)" + }, + { + "input": "Definition: Disease or Syndrome described as a rare life-threatening non-inflammatory vasculopathy disorder characterized by diffuse precipitation of calcium in viscera (mainly in the heart or lungs, but also in the stomach or kidneys) leading to fibrosis and thrombosis, which eventually cause necrotic ulcerations of the tissue. Patients may present with dyspnea, cough and respiratory failure or acute heart block and subsequent sudden cardiac death, depending on the affected organ. The disease mainly affects patients on dialysis or patients having undergone renal transplantation.\nConcepts: Recombinant Vaccinia-NY-ESO-1 Vaccine (Vaccinia Vaccine)\tOseltamivirum (Glycosidase inhibitor)\tProteoglycans (Proteins)\tVisceral calciphylaxis (Disease or Syndrome)\ttype b blood (Laboratory or Test Result)", + "output": "Visceral calciphylaxis (Disease or Syndrome)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G protein-coupled receptors.\nConcepts: arrestin family protein binding (Molecular Function)\tfatty-acyl-[acp] elongase/decarboxylase activity (Molecular Function)\tRCAMINT (Quantitative Concept)\tGPX150 (Organic Chemical)\t6: 114398967-114368621 (Chromosome 6 Physical Location)", + "output": "arrestin family protein binding (Molecular Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 17(E)-cheilanthenediol <=> all-trans-geranylfarnesol + H2O.\nConcepts: caring patient (Therapeutic procedure)\tsubclavian artery stenosis (Stricture of artery)\tFluoro-L-Thymidine-Positron Emission Tomography (Diagnostic Procedure)\t17(E)-cheilanthenediol synthase activity (hydro-lyase activity)\tcellular response to hydrocortisone stimulus (cellular response to ketone)", + "output": "17(E)-cheilanthenediol synthase activity (hydro-lyase activity)" + }, + { + "input": "Definition: Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 described as stage IVA includes: (T1-4a, N2, M0); (T4b, N0-2, M0); (Any T, N3, M0). T1: Tumor invades the lamina propria, muscularis mucosae, or submucosa. T2: Tumor invades the muscularis propria. T3: Tumor invades adventitia. T4a: Tumor invades the pleura, pericardium, azygos vein, diaphragm, or peritoneum. T4b: Tumor invades other adjacent structures, such as the aorta, vertebral body, or airway. N0: No regional lymph node metastasis. N1: Tumor with metastasis in one or two regional lymph nodes. N2: Tumor with metastasis in three to six regional lymph nodes. N3: Tumor with metastasis in seven or more regional lymph nodes. M0: No distant metastasis.\nConcepts: Nerves, Peroneal (Structure of sciatic nerve)\tMyodystrophy (Rare Non-Neoplastic Disorder)\tdynein light intermediate chain binding (Protein Binding)\tSolute Carrier Family 7 (Amino Acid Transporter, L-Type), Member 8 Gene (Gene or Genome)\tClinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8 (Neoplastic Process)", + "output": "Clinical Stage IVA Gastroesophageal Junction Adenocarcinoma AJCC v8 (Neoplastic Process)" + }, + { + "input": "Definition: Gene or Genome described as human GSTA4 wild-type allele is located in the vicinity of 6p12.1 and is approximately 17 kb in length. This allele, which encodes glutathione S-transferase A4 protein, plays a role in the metabolism of endogenous and exogenous small hydrophobic molecules.\nConcepts: DEXTROAMPHETAMINE SACCHARATE (Pharmacologic Substance)\tLocalized Bone Ewing Sarcoma (Ewing's sarcoma of bone)\tKnowledge level: postpartum maternal health (Finding)\tBilirubinometers, Cutaneous (Bilirubinometer)\tRP1-214M20.1 (Gene or Genome)", + "output": "RP1-214M20.1 (Gene or Genome)" + }, + { + "input": "Definition: Finding described as a subjective answer of very strong agreement regarding the importance of something.\nConcepts: BPRS-A - Blunted Affect (BPRS-A Clinical Classification Question)\tGrade 1 Thyroid Stimulating Hormone Increased, CTCAE (Finding)\tRAND Social Support Survey - Confide in or Talk to About Yourself (RAND Social Support Survey Questionnaire Question)\tVery important (Finding)\tWaste-Disposal Units (Medical Device)", + "output": "Very important (Finding)" + }, + { + "input": "Definition: something described as mental retardation in association with conjunctival telangiectasia and characteristic flat facies with small mouth and thin prolabia.\nConcepts: COXEN Score 32 (Finding)\tRedness Indicator (Finding)\tPremolars (Structure of permanent tooth)\tre-entry into mitotic cell cycle after pheromone arrest (Cell Function)\tCianchetti syndrome (Disease or Syndrome)", + "output": "Cianchetti syndrome (Disease or Syndrome)" + }, + { + "input": "Definition: Ureteric Anastomotic Leak, CTCAE described as severe symptoms; invasive intervention indicated\nConcepts: Cutaneous Apudoma (Malignant tumor of dermis)\tFoetal descent (Finding of arrangement of fetus)\tcryofibrinogen test (Chemical procedure)\tdown-regulation of retinal programmed cell death (negative regulation of programmed cell death)\tGrade 3 Ureteric Anastomotic Leak, CTCAE (Finding)", + "output": "Grade 3 Ureteric Anastomotic Leak, CTCAE (Finding)" + }, + { + "input": "Definition: Immunologic Factor described as a human monoclonal antibody directed against the negative immunoregulatory human cell surface receptor programmed cell death 1 (PD-1, PCD-1) protein, with potential immune checkpoint inhibitory and antineoplastic activity. Upon administration, cemiplimab-rwlc binds to PD-1, inhibits its binding to the PD-1 ligand programmed cell death-1 ligand 1 (PD-L1), and prevents the activation of its downstream signaling pathways. This may restore immune function through the activation of cytotoxic T cells. PD-1, a transmembrane protein in the immunoglobulin superfamily expressed on activated T cells, negatively regulates T-cell activation and effector function when activated by its ligand; it plays an important role in tumor evasion from host immunity. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C121540\" active clinical trials using this agent.\nConcepts: cemiplimab-RWLC (Immunologic Factor)\tbreast; carcinoma in situ, lobular with intraductal (Stage 0 Breast Carcinoma)\tPiedraia hortae (Fungus)\tTearing Pain (Tearing Pain)\tAlbendazole-containing product (benzimidazole)", + "output": "cemiplimab-RWLC (Immunologic Factor)" + }, + { + "input": "Definition: Disorder of glycoprotein metabolism described as a form of congenital disorders of N-linked glycosylation with characteristics of distal arthrogryposis (mild flexion contractures of the fingers, deviation of the distal phalanges, swan-neck deformity), retro-micrognathia, general muscle hypotonia, delayed psychomotor development, autism spectrum disorder (speech delay, abnormal use of speech, difficulties in initiating, understanding and maintaining social interaction, limited non-verbal communication), seizures, microcephaly and mild to moderate intellectual disability that becomes apparent with age. The disease is caused by mutations in the gene SLC35A3 (1p21).\nConcepts: Simulators, Training, Intravenous Insertion (Simulators, Training)\tSLC35A3-CDG - solute carrier family 35 member A3 congenital disorder of glycosylation (Distal arthrogryposis syndrome)\tCRSR01TC (CDISC Clinical Classification Terminology)\tReception of language (Mental functions of language)\tpulmo vulpis/fox's lung (Organic Chemical)", + "output": "SLC35A3-CDG - solute carrier family 35 member A3 congenital disorder of glycosylation (Distal arthrogryposis syndrome)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of the serine hydrolase monoacylglycerol lipase (MGLL), with potential use for the treatment of various central nervous system (CNS) diseases and with potential analgesic and anti-neuroinflammatory activities. Upon oral administration, MGLL inhibitor ABX-1431 targets and binds to MGLL, thereby inhibiting MGLL activity and preventing the breakdown and inactivation of endogenous 2-arachidonoylglycerol (2-AG). Increased 2-AG levels results in enhanced activation of the cannabinoid receptor 1 (CB1) in the CNS and enhanced CB1 endocannabinoid signaling in active neural circuits. Activation of CB1 helps modulate the endocannabinoid system and reduce neurotransmitter release, thereby decreasing overactive neural signaling. This induces analgesic, anti-inflammatory and various neurological effects that are caused by dysregulation of the endocannabinoid system and overactive neural signaling, including anxiolytic effects, reduced spasticity and decreased neurodegenerative effects. In addition, MGLL inhibition by ABX-1431 depletes the supply of the inflammatory signaling molecule arachidonic acid, thereby further alleviating pain and inflammation. CB1 plays a key role in the regulation of neurotransmission; increased CB1 activation decreases overactive neural signaling. MGLL, an enzyme that catalyzes the breakdown of 2-AG, regulates the activation of CB1 and CB2 to modulate neurotransmission and inflammatory signaling, respectively. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C148538\" active clinical trials using this agent.\nConcepts: pore biosynthesis in other organism (membrane disruption in other organism)\tvirus (German translation of the Medical Subject Headings)\tC-C motif chemokine 5 receptor activity (Molecular Function)\tserine hydrolase monoacylglycerol lipase inhibitor ABX-1431 (Pharmacologic Substance)\tVocational rehabilitation (regime/therapy)(procedure) (Other physical therapy therapeutic procedures)", + "output": "serine hydrolase monoacylglycerol lipase inhibitor ABX-1431 (Pharmacologic Substance)" + }, + { + "input": "Definition: Mediastinum described as the angled junction where the diaphragm meets the chest wall.\nConcepts: Recessus costodiaphragmaticus (Structure of pleural recess)\tBehavior management (Therapeutic or Preventive Procedure)\tatrial septum primum morphogenesis (Organ or Tissue Function)\tRosette Formations (Laboratory Procedure)\tAromanian Language (Language)", + "output": "Recessus costodiaphragmaticus (Structure of pleural recess)" + }, + { + "input": "Definition: Fusion Gene described as a fusion gene that results from a chromosomal translocation t(3;11)(q25;q23) which fuses either exon 7 or 8 of the MLL gene to nucleotide 150 of the GMPS gene. This rearrangement is associated with treatment-related acute myeloid leukemia.\nConcepts: MAEVAL (Professional or Occupational Group)\tMLL-GMPS Fusion Gene (Fusion Gene)\tooplasm (Cytoplasm)\tSecondary Clinical Study Sponsor (Organization)\tactivation of immune response by cell surface receptor signaling pathway (immune response-regulating cell surface receptor signaling pathway)", + "output": "MLL-GMPS Fusion Gene (Fusion Gene)" + }, + { + "input": "Definition: Mutated Ras Peptide described as a synthetic form of the Ras peptide containing a point mutation at position 12 (glycine to cysteine) with potential antineoplastic activity. Vaccination with this peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this Ras mutation, resulting in decreased tumor growth.\nConcepts: aerococcus (Bacterium)\tBermuda Grass Pollen IgG Antibody RAST Score Measurement (Laboratory Procedure)\tRas Peptide CYS (Amino Acid, Peptide, or Protein)\tPressure on spinal cord (Abnormality of the spinal cord)\tWilms Tumor on the X Gene (AMER1 gene)", + "output": "Ras Peptide CYS (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cutaneous Melanoma Pathologic Regional Lymph Nodes TNM Finding v6 described as cutaneous melanoma in which the regional lymph nodes cannot be assessed.\nConcepts: pNX Cutaneous Melanoma v6 (Finding)\tnutraceutical (Food)\tnuclear hormone receptor binding (RNA polymerase II-specific DNA-binding transcription factor binding)\tbemiparin sodium (Pharmacologic Substance)\tPITX2 gene (Transcription factor genes)", + "output": "pNX Cutaneous Melanoma v6 (Finding)" + }, + { + "input": "Definition: something described as the essential oil of the nutmeg (Myristica fragrans). Mace oil is used as a flavoring and in pharmaceuticals for its analgesic, antispasmodic, laxative, and stimulant activities.\nConcepts: Clearing Agent (Chemical Viewed Functionally)\tMace Essential Oil (Natural Products)\tdownregulation of lipid transport across blood brain barrier (negative regulation of transport across blood-brain barrier)\tregulation of exocyst assembly (regulation of vesicle docking)\tAdverse Event Seriousness Code (Intellectual Product)", + "output": "Mace Essential Oil (Natural Products)" + }, + { + "input": "Definition: CDISC SDTM Terminology described as terminology associated with the physical properties test name codelist of the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Melanoma of the Skin pM1b(0) TNM Finding v8 (Cutaneous Melanoma pM1b TNM Finding v8)\t1-deoxy-D-xylulose kinase activity (phosphotransferase activity, alcohol group as acceptor)\tPHSPRP (CDISC SEND Terminology)\tALDH2 (Amino Acid, Peptide, or Protein)\tFLOWMETER, NONBACK-PRESSURE COMPENSATED, BOURDON GAUGE (Medical Device)", + "output": "PHSPRP (CDISC SEND Terminology)" + }, + { + "input": "Definition: Intellectual Product described as GAIA Level 4 Prenatally Diagnosed Congenital Microcephaly is defined by three criteria: first, the fetus is at least 24 weeks gestational age (GA), with GA based on certain last menstrual period (LMP) date with confirmatory first or second trimester ultrasound (US) scan, OR uncertain LMP with second trimester ultrasound, intrauterine insemination (IUI), OR embryo transfer, OR certain or uncertain LMP with fundal height and no confirmatory first or second trimester scan; second, HC 2 SD below mean or less than 3 percentile according to fetal US scan using appropriate standardized reference charts according to GA and gender for the population (e.g., WHO growth reference charts if GA greater than or equal to 37 weeks and Intergrowth-21st reference charts for GA 24-36 weeks); third, HC at birth or autopsy is in the normal range using appropriate standardized reference charts according to GA and gender for the population, which means that this is NOT a case of prenatally diagnosed congenital microcephaly.\nConcepts: Viburnum prunifolium / black haw (Homeopathic remedies letter V)\tTADALAFIL (Coronary vasodialator)\tGlobal Alignment of Immunization safety Assessment in pregnancy Level 4 Prenatally Diagnosed Congenital Microcephaly (Intellectual Product)\tAbnormality of the wrist (Abnormality of upper limb joint)\tmicturition (Urinary Tract Physiological Processes)", + "output": "Global Alignment of Immunization safety Assessment in pregnancy Level 4 Prenatally Diagnosed Congenital Microcephaly (Intellectual Product)" + }, + { + "input": "Definition: Receptor described as members of a family of highly conserved proteins which are all cis-trans peptidyl-prolyl isomerases (PEPTIDYLPROLYL ISOMERASE). They bind the immunosuppressant drugs CYCLOSPORINE; TACROLIMUS and SIROLIMUS. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.\nConcepts: Stage IVC Oral Cavity Mucoepidermoid Carcinoma AJCC v6 and v7 (Stage IVC Oral Cavity Cancer AJCC v6 and v7)\tImmunophilins (Amino Acid, Peptide, or Protein)\tirritation; skin (Dermatologic disorders)\tLuteinization (Organ or Tissue Function)\tanorexia; nervosa (Anorexia Nervosa)", + "output": "Immunophilins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as a group of recordings taken during sleep that shows brain wave changes, eye movements, breathing rate, blood pressure, heart rate, and the electrical activity of the heart and other muscles. A polysomnogram may be used to help diagnose sleep disorders.\nConcepts: Haemolysis Hb-uria, ext.cause (Disease or Syndrome)\tSOAPP-R - How Often Taken More Pain Medication (Intellectual Product)\tFEV(1) (Adverse Event Associated with Pulmonary and Upper Respiratory Systems)\tpolysomnogram (Medical Image)\tSecondary syringomyelia (Central nervous system complication)", + "output": "polysomnogram (Medical Image)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 8p\nConcepts: 8p23-p22 (Chromosome band)\tregulation of collagen catabolic process (regulation of collagen metabolic process)\tMammalian Pathway for Cysteine Biosynthesis (Functional Concept)\tSUMO transferase activity (Molecular Function)\tOvarian, Fallopian Tube, and Primary Peritoneal Carcinoma TNM Finding v8 (Finding)", + "output": "8p23-p22 (Chromosome band)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a fiber pathway from the cerebral cortex to the striatum that is not readily distinguished in myelin-stained histological cross-sections ( Carpenter-1983 ).\nConcepts: Milliliter per Minute per Microgram per Meter Squared per Day (Quantitative Concept)\tVascular malformation of the lip (Anatomical Abnormality)\tchaperone-mediated protein transport (Cell Function)\tMyelocytes (granulocyte)\tcorticostriate fibers (Body Part, Organ, or Organ Component)", + "output": "corticostriate fibers (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: site, metastatic cancer described as a condition in which fluid containing cancer cells collects in the abdomen.\nConcepts: Ability to Write (Intellectual Product)\tDate Value (DataType)\tascites; malignant (Malignant tumor of peritoneum)\tIVD Test Reagent/Kits, Hematology, Control (IVD Test Reagent/Kits, Hematology)\tinfectious disease transmission (Diagnosis)", + "output": "ascites; malignant (Malignant tumor of peritoneum)" + }, + { + "input": "Definition: something described as compounds and drugs that react with CYSTINE and convert it into a compound that can be more easily metabolized or intracellularly transported. Drugs in this class have been used to treat CYSTINOSIS.\nConcepts: Repositioning of transposed great vessels (Congenital cardiovascular anomaly therapeutic procedures)\tB lymphoblastic leukemia/lymphoma, NOS (Precursor B-lymphoblastic lymphoma/leukemia)\tlipoyl synthase activity (acting on 2-oxoglutarate-dehydrogenase E2 protein (sulfurtransferase activity)\tfirst-line therapy (Line of Therapy)\tAgents, Cystine Depleting (Pharmacologic Substance)", + "output": "Agents, Cystine Depleting (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as additional description of the observation result. EXAMPLE(S): Comments from the investigator regarding the condition of the specimen or any other observation. Comments in addition to the specimen condition from the central or performing laboratory describing the specimen. OTHER NAME(S): NOTE(S):\nConcepts: Torturing Pain (Pain)\tCongenital Atresia of the larynx (Larynx)\tRUBIVIRUS (Togaviridae)\tResidential Treatment Facility, Mental Retardation and/or Developmental Disabilities (Health Care Related Organization)\tPerformedObservationResult.comment (Published Comment)", + "output": "PerformedObservationResult.comment (Published Comment)" + }, + { + "input": "Definition: detection of hydrogen ion described as the process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors.\nConcepts: detection of pH by chemoreceptor signaling (detection of hydrogen ion)\tHandle Your Money (Findings-Based Question)\tNon-Proliferative Fibrocystic Change (Breast Fibrocystic Disease)\tMesna-Ifosfamide-Mitoxantrone-Etoposide-Etoposide-Methylprednisolone-Cytarabine-Cisplatin (Regimen Used to Treat Hodgkin Lymphoma)\tprecorrin-8X 11,12-methylmutase activity (intramolecular transferase activity, transferring acyl groups)", + "output": "detection of pH by chemoreceptor signaling (detection of hydrogen ion)" + }, + { + "input": "Definition: regulation of systemic arterial blood pressure by hormone described as the process in which renin-angiotensin modulates the force with which blood passes through the circulatory system.\nConcepts: mottled (Discoloration of skin)\tElevated faecal pH (Abnormal fecal pH)\tETS Domain-Containing Protein Elk-4 (TRANSCRIPTION FACTOR)\tADMIN PUBLIC HEALTH (Administrative Activity)\tregulation of systemic arterial blood pressure by renin-angiotensin (regulation of systemic arterial blood pressure by hormone)", + "output": "regulation of systemic arterial blood pressure by renin-angiotensin (regulation of systemic arterial blood pressure by hormone)" + }, + { + "input": "Definition: starch grain described as plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped.\nConcepts: ADL0215A (ADCS-ADL Severe Dementia Questionnaire Question)\tamyloplast starch grain (starch grain)\tlipopolysaccharide core region biosynthesis (oligosaccharide biosynthetic process)\tHow much of the time did your caregiving responsibilities make it difficult for you to get going easily at the beginning of your workday (Intellectual Product)\tInfection;kidney (Upper urinary tract infection)", + "output": "amyloplast starch grain (starch grain)" + }, + { + "input": "Definition: something described as techniques used to measure velocity and amount of blood flow and circulation in the living system.\nConcepts: embryonic brain development (embryonic organ development)\tCirculatory function tests (Cardiovascular measure)\tUterine Corpus Carcinoma and Carcinosarcoma Clinical Distant Metastasis TNM Finding v8 (Finding)\tSetaria (Poaceae)\tRoland Morris Disability Questionnaire Questionnaire Test Name (CDISC Questionnaire Terminology)", + "output": "Circulatory function tests (Cardiovascular measure)" + }, + { + "input": "Definition: Magnetic Phenomena described as characteristics of ELECTRICITY and magnetism such as charged particles and the properties and behavior of charged particles, and other phenomena related to or associated with electromagnetism.\nConcepts: Electromagnetic Phenomenon (Magnetic Phenomena)\t1H-Indazole-3-carboxamide, 1-methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-, endo- (5-HT>3< receptor antagonist)\tLipemic Index (Specimen characteristics)\t16p12 (Cell Component)\tHypopharyngeal Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)", + "output": "Electromagnetic Phenomenon (Magnetic Phenomena)" + }, + { + "input": "Definition: Cell Component described as the membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus.\nConcepts: Walker-Warburg Syndrome Gene Mutation Panel Reagents (IVD Panels, Human Genetics, Neuromuscular Disorder, Muscular Dystrophy, Walker-Warburg Syndrome)\tL-lysine carboxy-lyase (Molecular Function)\tHealthcare Proxy (Advance Directives)\tperinuclear ER membrane (Membrane)\tMATEST (Intellectual Product)", + "output": "perinuclear ER membrane (Membrane)" + }, + { + "input": "Definition: something described as this gene plays a role in enzyme metabolism.\nConcepts: Encephalitis, Tick-borne (Encephalitis due to tick-borne encephalitis virus subgroup)\tHuman Papillomavirus 11 Antibody (Immunologic Tests)\tCPA1 gene (Metallopeptidase Gene)\tmitochondrial valyl-tRNA aminoacylation (valyl-tRNA aminoacylation)\tAsclepias incarnata / swamp milkweed (Pharmacologic Substance)", + "output": "CPA1 gene (Metallopeptidase Gene)" + }, + { + "input": "Definition: Inflammatory dermatosis described as a recurrent contact dermatitis caused by substances found in the work place.\nConcepts: Periostitis at sites of tendon insertions present (Finding)\tPRKCD Gene (Serine/Threonine Protein Kinase Gene)\tclathrin-coated endocytic vesicle (Early endosome)\toccupational dermatitis (Dermatitis)\tSENP1/MESDC2 Fusion Gene (Gene or Genome)", + "output": "occupational dermatitis (Dermatitis)" + }, + { + "input": "Definition: Intellectual Product described as a question about how often an individual experienced abdominal bulging.\nConcepts: Radical Tympanomastoidectomy (Therapeutic or Preventive Procedure)\tDiestrus (estrous cycle phase)\tCSS0803A (Intellectual Product)\tAkt (Proto-Oncogene Proteins)\tAbdominal bulging (Intellectual Product)", + "output": "Abdominal bulging (Intellectual Product)" + }, + { + "input": "Definition: Structure of apicoposterior branch of superior left pulmonary vein described as posterior segmental vein, each instance of which drains the posterior segment of the upper lobe (superior) lobe of some left lung.\nConcepts: N3 Lymph Node Stage (N Stage)\tLeft posterior segmental vein (Body Part, Organ, or Organ Component)\tcellular component movement (cellular process)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, ACTC1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication)\tAng-2 Measurement (Protein or Enzyme Type Measurement)", + "output": "Left posterior segmental vein (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: sociocultural discrimination concepts described as group behavior toward others by virtue of their group membership.\nConcepts: Transfer (Learning)\ttransfection (genetic manipulation)\tLENS (Device Component or Accessory)\tSocial Discrimination (Social issues)\tPLAG1/CTNNB1 FUSION GENE (Fusion Gene)", + "output": "Social Discrimination (Social issues)" + }, + { + "input": "Definition: CPTAC Questions described as a question about whether another form of birth control was ever used.\nConcepts: 1: 109942484-109948409 (Spatial Concept)\tVascular Coronary Artery Stylets (Medical Device)\tReynolds CVD 10-Year Risk Score Clinical Classification Question (Intellectual Product)\tdata quality/integrity (Data Collection)\tWas another Form of Birth Control Ever Used (Intellectual Product)", + "output": "Was another Form of Birth Control Ever Used (Intellectual Product)" + }, + { + "input": "Definition: neoplasm/cancer type described as a neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.\nConcepts: Benign adenoma (Adenoma)\tWar, Gulf (Activity)\tPROSTHESIS, WRIST, CONSTRAINED, METAL (Medical Device)\tRudivirus (Virus)\tGolgi to plasma membrane transport (post-Golgi vesicle-mediated transport)", + "output": "Benign adenoma (Adenoma)" + }, + { + "input": "Definition: Disease or Syndrome described as a morphologic finding indicating the presence of mild dysplastic cellular changes and mild architectural changes in the glandular epithelium of the rectal mucosa. There is no evidence of invasion.\nConcepts: Non-Neoplastic Pituitary Gland Disorder (Disease or Syndrome)\tMild Dysplasia of the Rectum (Dysplasia of rectum)\tdown regulation of filamentous growth of a population of unicellular organisms in response to neutral pH (regulation of filamentous growth of a population of unicellular organisms in response to neutral pH)\tCheckpoint Blockade Immunotherapy (Immunotherapy for cancer)\tiliac fossa (General anatomical term)", + "output": "Mild Dysplasia of the Rectum (Dysplasia of rectum)" + }, + { + "input": "Definition: Lead Event Finding described as the cardiac lead has been left in situ but is not in use.\nConcepts: Abandoned Lead (Lead Event Finding)\tsphing-4-enine metabolic process (Molecular Function)\tIPA0310B (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tIncreased pigmentation around the mouth (Finding)\tDerealization (Mental or Behavioral Dysfunction)", + "output": "Abandoned Lead (Lead Event Finding)" + }, + { + "input": "Definition: Cell Function described as the disaggregation of a protein-DNA-RNA complex into its constituent components.\nConcepts: Chest-Wall Compression Units, Vest (Airway Clearance Units, High-Frequency Chest Wall Oscillation)\tPapillomas, Choroid Plexus (Neoplastic Process)\tprotein-DNA-RNA complex disassembly (protein-containing complex disassembly)\tDeath Certificates (health records)\thepatocellular carcinoma-associated protein p28-II, human (Structural protein)", + "output": "protein-DNA-RNA complex disassembly (protein-containing complex disassembly)" + }, + { + "input": "Definition: mineral analysis described as a measurement of the arsenic in a biological specimen.\nConcepts: Dysgraphia (Speech Disorders)\tPatchy sclerosis of 5th finger phalanx (Sclerosis of 5th finger phalanx)\t9H-Purin-6-amine, 9-(5-O-phosphono-beta-D-arabinofuranosyl)- (Nucleic Acid, Nucleoside, or Nucleotide)\tMeasurement of arsenic (SPECIFIC DRUG AND TOXICOLOGY TESTS)\tReproductive System Neoplasm, Female (NCI CTEP Simplified Disease Classification Terminology)", + "output": "Measurement of arsenic (SPECIFIC DRUG AND TOXICOLOGY TESTS)" + }, + { + "input": "Definition: something described as baby Eating Behaviour Questionnaire Retrospective Version (BEBQ Retrospective Version) My baby had a big appetite.\nConcepts: down regulation of endothelial cell proliferation (negative regulation of epithelial cell proliferation)\tBlasts 20-30 Percent of Bone Marrow Nucleated Cells (Finding)\tGlyceraldehyde-3-Phosphate Dehydrogenases (Amino Acid, Peptide, or Protein)\tP2Y4 nucleotide receptor binding (G protein-coupled nucleotide receptor binding)\tBEBQ02-Baby Had a Big Appetite (Intellectual Product)", + "output": "BEBQ02-Baby Had a Big Appetite (Intellectual Product)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a humanized monoclonal antibody directed against parathyroid hormone-related protein (PTH-rP). As a poly-hormone with diverse biological roles, PTH-rP is expressed by normal tissues, acting in local tissue environments in a variety of ways; it is commonly overexpressed by breast, prostate, and other cancers, acting systemically by promoting bone resorption, inhibiting calcium excretion from the kidney, inducing hypercalcemia, and possibly playing a role in the formation of bony metastases. By blocking the effects of PTH-rP on calcium metabolism, monoclonal antibody CAL may inhibit cancer-related hypercalcemia. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2659\" active clinical trials using this agent.\nConcepts: Gastric Neuroendocrine Tumor cM1b TNM Finding v8 (Gastric Neuroendocrine Tumor cM1 TNM Finding v8)\tGenus Caldicellulosiruptor (Firmicutes)\tMonoclonal Antibody CAL (Antineoplastic Antibody)\tT\u00e9mozolomide (Pharmacologic Substance)\tguanylate cyclase 1 soluble subunit beta (Protein Complex Subunit Gene)", + "output": "Monoclonal Antibody CAL (Antineoplastic Antibody)" + }, + { + "input": "Definition: Chemical Moiety described as a chemical fragment that represents a single repeating structure in a polymer.\nConcepts: L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity (S-adenosylmethionine-dependent methyltransferase activity)\tLaboratory Specimen Type (Biospecimen Type)\tcarcinoma in situ of cecum (Carcinoma in situ of intestinal tract)\tspine fracture (Spinal Diseases)\tStructural Repeat Unit (Functional Concept)", + "output": "Structural Repeat Unit (Functional Concept)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity Version 4 (FACT/GOG-NTX Version 4) Emotional Well-Being: I feel sad.\nConcepts: interleukin-7-mediated signalling pathway (cytokine-mediated signaling pathway)\talpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol (Antibiotics, Antifungal)\tFAC05715 (Intellectual Product)\tNumber of Other Lymph Nodes Positive for Tumor by IHC staining only (Numbers)\tStaphylococcus equorum (Bacterium)", + "output": "FAC05715 (Intellectual Product)" + }, + { + "input": "Definition: something described as this virus is a spontaneous mutant of SV7, a molecular clone of MoMuSV124. Like SV7, R7 induces subcutaneous fibrosarcomas, spleen tumors, and mesentery tumors infiltrated by proliferating vessels lined by transformed endothelial cells. However, it also induces brain lesions. (from Virology. 1997 Sep 15;236(1):213-8)\nConcepts: melatonin receptor binding (Molecular Function)\tgenital disc sexually dimorphic development (developmental process involved in reproduction)\trvaccinia-prostate-specific antigen-TRICOM vaccine (Pharmacologic Substance)\tMUNC13 (UNC13B gene)\tRecombinant 7 (Virus)", + "output": "Recombinant 7 (Virus)" + }, + { + "input": "Definition: Intellectual Product described as alcohol Use Disorder Identification Test Self-Report Version (AUDIT) Total.\nConcepts: assisted reproductive technology (Fertility and fertilisation interventions female)\tADT01-Total (AUDIT Questionnaire Question)\tmorphogenesis of follicular epithelium (morphogenesis of an epithelium)\tConcept, Cardiovascular Physiological (General Cardiovascular Functions)\tanimation (Intellectual Product)", + "output": "ADT01-Total (AUDIT Questionnaire Question)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as interleukin enhancer-binding factor 2 (390 aa, ~43 kDa) is encoded by the human ILF2 gene. This protein plays a role in the regulation of IL2 gene transcription, nonhomologous end joining DNA repair and mRNA export.\nConcepts: SRC Tyrosine Kinase Activation Pathway (Molecular Function)\tILF2 protein, human (Biologically Active Substance)\tGAIA Level 2 Vasa Previa (GAIA Antenatal Bleeding Level of Diagnostic Certainty)\tAnatomical orifice (Body Space or Junction)\tSelect Exposure Types (Form Directive)", + "output": "ILF2 protein, human (Biologically Active Substance)" + }, + { + "input": "Definition: Organism Function described as establishment of the epithelial barrier, the functional barrier in the skin that limits its permeability.\nConcepts: IVD Panels, Human Genetics, Encephalopathy, Autism Spectrum Disorder, Del/Dup (Medical Device)\tskin barrier development (Organism Function)\tFriendly (General Qualifier)\tPSEC0087 (GPRC5C gene)\tmediator complex assembly (cellular protein-containing complex assembly)", + "output": "skin barrier development (Organism Function)" + }, + { + "input": "Definition: something described as linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.\nConcepts: Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) Gene (Gene or Genome)\tAbsent middle bone of the 3rd toe (Aplasia of the middle phalanges of the toes)\ttestosterone cypionate (Androstanes)\tProduct containing protein (Biologically Active Substance)\tciliary orbiculus (Body Part, Organ, or Organ Component)", + "output": "Product containing protein (Biologically Active Substance)" + }, + { + "input": "Definition: Epithelioid sarcoma metastatic described as epithelioid sarcoma that has spread from its original site of growth to nearby tissues or lymph nodes.\nConcepts: Sparsomycin (Pyrimidinones)\tLocally Advanced Epithelioid Sarcoma (Locally Advanced Soft Tissue Sarcoma)\tOpenness to Experience (Temperament and personality functions)\tFisher Scientific (Company)\tHow much of the time did your caregiving responsibilities make it difficult for you to keep your mind on your work (Intellectual Product)", + "output": "Locally Advanced Epithelioid Sarcoma (Locally Advanced Soft Tissue Sarcoma)" + }, + { + "input": "Definition: bounding membrane of organelle described as the lipid bilayer surrounding the smooth endoplasmic reticulum.\nConcepts: Smooth endoplasmic reticulum wall (Cell Component)\tdays of the week (Time descriptors of days, weeks and years)\tOMACICLOVIR (Antiviral Agents)\tImage Plane (Anatomic Plane)\tCompensatory head tilt to the left shoulder (Finding)", + "output": "Smooth endoplasmic reticulum wall (Cell Component)" + }, + { + "input": "Definition: something described as HPV-mediated (p16-positive) oropharyngeal cancer in which the regional lymph nodes cannot be assessed.\nConcepts: Heart--Transplantation (HEART: TRANSPLANTATIONS AND TRANSPOSITIONS)\tTaking a bath (Intellectual Product)\tHPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pNX TNM Finding v8 (Finding)\tRetinoic Acid Agent (Targeted Therapy Agent)\tregulation of contractile ring contraction involved in cell cycle cytokinesis (cytokinetic process)", + "output": "HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma pNX TNM Finding v8 (Finding)" + }, + { + "input": "Definition: something described as hyperlinks in documents.\nConcepts: Nebulisation use (Functional Concept)\tHyperlink (List)\tAIDS Study (Clinical Study by Targeted Disease or Condition)\tDefined Notification Delivery Mechanism Code (Intellectual Product)\tBiogenic Monoamines (Biologically Active Substance)", + "output": "Hyperlink (List)" + }, + { + "input": "Definition: COXEN Sensitivity Scale described as a score of 35 on the COXEN Sensitivity Scale.\nConcepts: Exocrine gland (General anatomical term)\tNociceptive Pain (Sign or Symptom)\tCOXEN Score 35 (COXEN Sensitivity Scale)\tlymphoma, non-hodgkin's, colon (Colorectal Non-Hodgkin Lymphoma)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, FCMD (Medical Device)", + "output": "COXEN Score 35 (COXEN Sensitivity Scale)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a therapy designed to induce changes in a patient's immune status.\nConcepts: regulation of late stripe melanocyte differentiation (regulation of melanocyte differentiation)\tImmunological care (Therapeutic procedure)\ttriploidy syndrome (Karyotype morphology)\tFollow-Up Outcome Expectations Questionnaire (Intellectual Product)\tPhysical Conditionings, Animal (Biologic Function)", + "output": "Immunological care (Therapeutic procedure)" + }, + { + "input": "Definition: something described as focal (localized) slow activity reflects focal dysfunction, not diffuse dysfunction (i.e., encephalopathy).\nConcepts: tRNA modification (RNA modification)\tLess than 1 year (Intellectual Product)\tBlood Flow Detectors (Detectors)\tEEG: localised slow activity (EEG with abnormally slow frequencies)\tTesticular Sertoli Cell Tumor, Lipid Rich Variant (Neoplastic Process)", + "output": "EEG: localised slow activity (EEG with abnormally slow frequencies)" + }, + { + "input": "Definition: something described as substances, usually endogenous, that act as inhibitors of blood coagulation. They may affect one or multiple enzymes throughout the process. As a group, they also inhibit enzymes involved in processes other than blood coagulation, such as those from the complement system, fibrinolytic enzyme system, blood cells, and bacteria.\nConcepts: PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child - Hard to Use Hands (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question)\tARHGAP14 (SRGAP3 gene)\tHPV-Mediated (p16-Positive) Oropharyngeal Cancer cN1 TNM Finding v8 (Finding)\tINHIB COAG FACTORS BLOOD (Biologically Active Substance)\tpositive regulation of macrophage cytokine production (regulation of macrophage cytokine production)", + "output": "INHIB COAG FACTORS BLOOD (Biologically Active Substance)" + }, + { + "input": "Definition: Renal cortical cysts described as cysts of microscopic size confined to the cortex of the kidney.\nConcepts: laryngectomee (Patient or Disabled Group)\tcnstxnl hydrothrp W/Osne wve (Hydrotherapy)\tMacroglobulinaemia, Familial Waldenstrom's (Waldenstrom Macroglobulinemia)\tMultiple small renal cortical cysts (Finding)\tpyrrolidone (Organic Chemical)", + "output": "Multiple small renal cortical cysts (Finding)" + }, + { + "input": "Definition: Intellectual Product described as inventory of Depressive Symptomatology Clinician-Rated Version (IDS-C) Please circle one response to each item that best describes the patient for the last seven days: Weight (increase) within the last two weeks.\nConcepts: IDSC1-Weight (IDS-C Clinical Classification Question)\tPERICARDIOCENTESIS (Drainage of heart)\tautologous human anti-CD19CAR-4-1BB-CD3zeta-EGFRt-expressing CD4+/CD8+ T lymphocytes (Cell)\tSuture Units, Endoscopic, Lower Esophageal Sphincter (Medical Device)\tPredictor (Diagnostic or Prognostic Factor)", + "output": "IDSC1-Weight (IDS-C Clinical Classification Question)" + }, + { + "input": "Definition: Ear structure described as benign congenital lesion of the supraauricular soft tissue consisting of a blind-ending narrow tube or pit.\nConcepts: EORTC QLQ-C30 Version 3 - Rate Your Overall Quality of Life (EORTC QLQ-C30 Version 3 Questionnaire Question)\tEAST ASIAN (Population Group)\tSupraauricular sinus (Ear structure)\tOccasional Urinary Accident (Clinical or Research Assessment Answer)\tPhlebotomy: Cannulated Vessel (Laboratory Procedure)", + "output": "Supraauricular sinus (Ear structure)" + }, + { + "input": "Definition: Allergy testing described as performing an allergy profile on a client/patient for up to eight allergy antigens to assess his or her allergic response(s). Service is billed per test.\nConcepts: GERMANY (Historical Geographic Locations)\talrg prfle 1-8 Itms ea.tst (Laboratory Procedure)\teye patch@@MISCELL@EACH (Ophthalmic device)\tEchocardiographic Recorders (Medical Device)\tBacteroides aerofaciens (Collinsella)", + "output": "alrg prfle 1-8 Itms ea.tst (Laboratory Procedure)" + }, + { + "input": "Definition: Molecular Function described as combining with the C1q complex, a component of the classical complement cascade, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.\nConcepts: complement component C1q receptor activity (Molecular Function)\tupregulation of protein localization to cilium (positive regulation of cellular protein localization)\turidine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity (Molecular Function)\tsubstrate-independent telencephalic tangential migration (Cell Function)\tAdvanced Pancreatic Carcinoma (Advanced Digestive System Carcinoma)", + "output": "complement component C1q receptor activity (Molecular Function)" + }, + { + "input": "Definition: Intellectual Product described as an identifier that is marked directly on the medical device and is different than the Primary DI; only applicable to devices subject to Direct Marking requirements under 21 CFR 801.50.\nConcepts: DM DI Number (Intellectual Product)\tglutathione disulphide oxidoreductase activity (Molecular Function)\theart; stoppage (Heart disease other)\tGuanidine, N''-Cyano-N-Methyl-N'-(2-(((5-Methyl-1H-Imidazol-4-yl)Methyl)Thio)Ethyl)- (Drug allergens)\tSpino-olivary tract structure (Central nervous system tract structure)", + "output": "DM DI Number (Intellectual Product)" + }, + { + "input": "Definition: Peripheral T-cell lymphomas NEC described as a group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. They include a broad spectrum of lymphocyte morphology, but in all instances express T-cell markers admixed with epithelioid histiocytes, plasma cells, and eosinophils. Although markedly similar to large-cell immunoblastic lymphoma (LYMPHOMA, LARGE-CELL, IMMUNOBLASTIC), this group's unique features warrant separate treatment.\nConcepts: epithelial cell differentiation involved in embryonic placenta development (epithelial cell differentiation)\tcapsular-polysaccharide 3-deoxy-D-manno-2-octulosonohydrolase activity (Molecular Function)\tlymphoma; T-cell, peripheral (Neoplastic Process)\tED107 6B (Expanded DRS-PI Caregiver Version Questionnaire Question)\tConvergence excess esotropia (Esotropia)", + "output": "lymphoma; T-cell, peripheral (Neoplastic Process)" + }, + { + "input": "Definition: something described as a question about an individual's ability to run or jog 1 mile.\nConcepts: Running or jogging 1 mile (Clinical or Research Assessment Question)\tAvailabilities, Biological (Quantitative Concept)\toxidoreductase activity, acting on CH or CH2 groups (oxidoreductase activity)\tOlfactory Tubercle (Cerebral basal surface structure)\tTubular adenocarcinoma gastric (Gastric Adenocarcinoma)", + "output": "Running or jogging 1 mile (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Country described as a country in Central Europe, east of Germany.\nConcepts: Escape Progressing to Mid-Chin (Impairment of Lip Closure)\tChad (Geographic Area)\tCountry of Poland (Country)\tback injuries (Bones, Joints and Muscles)\tGenus Aeromonas (Aeromonadaceae)", + "output": "Country of Poland (Country)" + }, + { + "input": "Definition: Qualitative Concept described as a descriptive characterization of the size of the left cardiac ventricle.\nConcepts: obstruction; artery, retina, transient (Occlusion of artery)\tLeft Ventricle Size, Qualitative (Qualitative Concept)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Child Questionnaire Question (Intellectual Product)\tLEUKOTRIENE B 04 (Leukotrienes)\tELA4 Gene Mutation (Cell or Molecular Dysfunction)", + "output": "Left Ventricle Size, Qualitative (Qualitative Concept)" + }, + { + "input": "Definition: Disease or Syndrome described as an acquired form of intestinal lymphangiectasia manifesting as a protein-losing enteropathy. May be due to another disorder such as Crohn's disease, congestive heart failure, sarcoidosis, Turner syndrome or in patients who have undergone a Fontan operation.\nConcepts: Risk control behavior: drug use (Individual Behavior)\tSecondary intestinal lymphangiectasis (Disease or Syndrome)\tVulvar Cloacogenic Adenocarcinoma (Adenocarcinoma, intestinal type)\tNot More Than (RelationalOperator - CodeSystem)\tInterferometry (Laboratory Procedure)", + "output": "Secondary intestinal lymphangiectasis (Disease or Syndrome)" + }, + { + "input": "Definition: Bladder and bladder neck disorders described as tumors or cancer of the URINARY BLADDER.\nConcepts: Neoplasm of Bladder (Malignant Neoplasms)\tSurgical Casts (Orthopedic Fixation Devices)\tStability Container Type Terminology (FDA Stability Data Standards Terminology)\tdelta7-sterol 5-desaturase activity (sterol desaturase activity)\tTingling sensation (\"pins and needles\") in the underarm, arm or hand (Intellectual Product)", + "output": "Neoplasm of Bladder (Malignant Neoplasms)" + }, + { + "input": "Definition: Immunologic Tests described as the determination of the amount of microfilaria present in a sample.\nConcepts: Reduced beta/alpha synthesis ratio (Imbalanced hemoglobin synthesis)\tGrade 2 Bone Pain, CTCAE (Finding)\tMicrofilaria (Immunologic Tests)\tStoma site, NOS (Stoma AND/OR site of stoma)\tGowers disease (Autosomal dominant hereditary disorder)", + "output": "Microfilaria (Immunologic Tests)" + }, + { + "input": "Definition: Skin, Human described as a dimpled condition of the skin of the breast, resembling the skin of an orange, sometimes found in inflammatory breast cancer.\nConcepts: Business Operation (FDA Structured Product Labeling Terminology)\tCYP2C19, c.1297C>T (CYP2C19 gene)\tpsychometric Minnesota Multiphasic Personality Inventory (MMPI) (Personality inventories)\tInfection of digestive system (Communicable Diseases)\tskin texture peau d'orange (Appearance of breast)", + "output": "skin texture peau d'orange (Appearance of breast)" + }, + { + "input": "Definition: Sequela of disorder described as a disorder that follows infection but is distinct from the infection itself and its usual manifestations\nConcepts: beta-carotene anabolism (carotene biosynthetic process)\tKIAA1968 (AKNA gene)\tPostinfectious disorder (Pathologic Function)\tOverall Grade 1 (Nottingham Grade)\tCraniotomy Patient (Patient or Disabled Group)", + "output": "Postinfectious disorder (Pathologic Function)" + }, + { + "input": "Definition: Medical Device described as proximal inter-phalangeal (PIP) orthoses that are dynamic splints designed to provide external forces that produce flexion to the PIP joint during therapeutic treatment. These orthoses typically consist of a padded splint with a strap encircling the hand while the splint extends along the affected finger. The splint includes elastic bands from the hand strap that are attached to a cuff placed around the finger. Dynamic splints are used for therapy after surgical correction of IP deformities.\nConcepts: Rounds, Teaching (Health Care Activity)\tOrthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic, Dynamic Splint (Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic)\tLCM virus infection (Viral meningitis)\tleaf phyllotactic patterning (Organ or Tissue Function)\tConjunctival Carcinoma pT2 TNM Finding v8 (Conjunctival Carcinoma Pathologic Primary Tumor TNM Finding v8)", + "output": "Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic, Dynamic Splint (Orthoses, Upper Limb, Finger, Inter-Phalangeal Joint, Proximal, Therapeutic)" + }, + { + "input": "Definition: something described as framingham Heart Study Cardiovascular Disease 10-Year Risk Score (FCVD1-Framingham CVD 10-Year Risk Score) Risk score.\nConcepts: Leukotriene Degradation (Molecular Function)\tFCVD101 (Finding)\tMSQL1-Phys Health: Accomplish Less (Intellectual Product)\tNAD(P)H:sulfur oxidoreductase activity (Molecular Function)\tMannosidase (Hydrolase)", + "output": "FCVD101 (Finding)" + }, + { + "input": "Definition: Inflammatory disorder described as any disorder that results from the consumption of food contaminated with an infectious agent or toxin.\nConcepts: related RAS viral (r-ras) oncogene homolog protein, human (Amino Acid, Peptide, or Protein)\tPOIS FOOD (Digestive System Disorders)\tstage IV marginal zone lymphoma (Stage IV Indolent Adult Non-Hodgkin Lymphoma)\tGnathostoma spinigerum (Thelazioidea)\tleukemia, hairy cell, untreated (Finding)", + "output": "POIS FOOD (Digestive System Disorders)" + }, + { + "input": "Definition: something described as clone negative. Note: A T-cell clone is defined by PCR or Southern blot analysis of the T-cell receptor gene.\nConcepts: Session (Activity Session)\tarea TAa of Seltzer-1978 (Body Part, Organ, or Organ Component)\tcerv.pillow THERAP.ea.Itm (Materials and/or supplies)\tPhosphorous 5+ (Dietary Phosphorus)\tMycosis Fungoides and S\u00e9zary Syndrome N1a TNM Finding v7 (Mycosis Fungoides and Sezary Syndrome N1 TNM Finding v7)", + "output": "Mycosis Fungoides and S\u00e9zary Syndrome N1a TNM Finding v7 (Mycosis Fungoides and Sezary Syndrome N1 TNM Finding v7)" + }, + { + "input": "Definition: Type of drug preparation described as solid, semi-solid or liquid preparation to be added to the bath water.\nConcepts: Bath additive (Biomedical or Dental Material)\tHumeral Component Trial Prostheses (Medical Device)\tTarget Anatomic Site Laterality Code (Code)\tBenign Tumor of Hard Palate (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE DIGESTIVE SYSTEM)\tRecurrent Childhood Optic Tract Astrocytoma (Neoplastic Process)", + "output": "Bath additive (Biomedical or Dental Material)" + }, + { + "input": "Definition: Finding described as an assessment of the diffusion capacity of the lungs for carbon monoxide adjusted for hemoglobin concentration.\nConcepts: Manual (Books)\tS. pneumonia Sero 1 IgG AB (Laboratory Procedure)\tHGB Corrected DLCO (Finding)\tLaparoscopic Radical Prostatectomy without Robotics (Therapeutic or Preventive Procedure)\tUterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma pT0 TNM Finding v8 (Uterine Corpus Leiomyosarcoma and Endometrial Stromal Sarcoma Pathologic Primary Tumor TNM Finding v8)", + "output": "HGB Corrected DLCO (Finding)" + }, + { + "input": "Definition: something described as a subjective score of 2 on a scale that ranges from 0: Does Not Interfere to 10: Completely Interferes.\nConcepts: ANTIGENS, CF, ALL, MYCOPLASMA SPP. (Indicator, Reagent, or Diagnostic Aid)\tMilitary Nuclear Weapon (Manufactured Object)\tGeographic Mapping (Epidemiologic Methods)\tBPI Pain Interference Score 2 (Clinical or Research Assessment Answer)\tLow Voltage in Limb Leads Only by ECG Finding (Finding)", + "output": "BPI Pain Interference Score 2 (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as a collaborative effort to develop a common exchange format for biological pathways data.\nConcepts: BioPAX (Professional Organization or Group)\tPacific Ocean (Oceans and Seas)\tNeoplasm of respiratory system (Abnormality of the respiratory system)\tsteroid hormone mediated signalling (Molecular Function)\tneurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration (motogenic signaling initiating cell movement in cerebral cortex)", + "output": "BioPAX (Professional Organization or Group)" + }, + { + "input": "Definition: Eukaryota described as a genus of protozoan parasites found in the intestines of birds, amphibians, reptiles, and mammals, including man. The oocysts produce two sporocysts, each with four sporozoites. Many species are parasitic in wild and domestic animals.\nConcepts: Georgian S.S.R. (Commonwealth of Independent States)\tHow Often Thinking Has Been Slow (Clinical or Research Assessment Question)\tISOSPORA (Eimeriidae)\tKI (Country)\tC165920 (Immunoglobulin G measurement)", + "output": "ISOSPORA (Eimeriidae)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the EPCAM gene.\nConcepts: host cell centrosome (Cell Component)\tConcentrate for concentrate for oral spray, suspension (Concentrated Solution Dosage Form)\tHNPCC8 Gene Mutation (Gene Mutant)\tConveyors (Healthcare facility device and adaptation)\tbeta-sitosterol UDP-glucosyltransferase activity (Molecular Function)", + "output": "HNPCC8 Gene Mutation (Gene Mutant)" + }, + { + "input": "Definition: something described as a measurement of the Chlamydia trachomatis IgA antibody in a biological specimen.\nConcepts: CTRIGAAB (Immunologic Tests)\tMaxillary Sinus Cancer pT4a TNM Finding v7 (Maxillary Sinus Cancer Pathologic Primary Tumor TNM Finding v7)\tCongenitally corrected transposition of the great arteries with ventricular septal defect (Congenitally Corrected Transposition of the Great Arteries)\tTeach individual safety (Procedure with a procedure focus)\tGrade 3 Esophageal Stenosis, CTCAE (Finding)", + "output": "CTRIGAAB (Immunologic Tests)" + }, + { + "input": "Definition: something described as a selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.\nConcepts: Terbutaline (Sympathomimetics)\thereditary papillary renal cell carcinoma (Malignant neoplasm of kidney)\tAntirheumatic Drug, Disease-Modifying (Pharmacologic Substance)\tAppendiceal Carcinoma Pathologic TNM Finding v8 (Appendiceal Carcinoma TNM Finding v8)\tfruit (Plant Part)", + "output": "Terbutaline (Sympathomimetics)" + }, + { + "input": "Definition: Biologic Function described as the process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue.\nConcepts: sporocyte differentiation (Cell Differentiation process)\tantigen sampling in mucosal-associated lymphoid tissue (Biologic Function)\tkiller cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3 protein, human (receptor)\tSERD LSZ102 (Selective Estrogen Receptor Down Regulator)\tGrade III (Tumor finding)", + "output": "antigen sampling in mucosal-associated lymphoid tissue (Biologic Function)" + }, + { + "input": "Definition: plasma membrane protein complex described as a protein complex that consists of an alphaIIb-beta3 integrin complex bound to the cell surface antigen CD47 and the kinase FAK.\nConcepts: doubling time (Temporal Concept)\tPACK, HOT OR COLD, REUSEABLE (Medical Device)\tFalls on stairs, steps or curbs (Finding)\tITGA2b-ITGB3-CD47-FAK complex (Cell Component)\tGet Anxious About Having Needle Sticks (Clinical or Research Assessment Question)", + "output": "ITGA2b-ITGB3-CD47-FAK complex (Cell Component)" + }, + { + "input": "Definition: something described as a nucleotide substitution at position 37 of the coding sequence of the KRAS gene where guanine has been mutated to cytosine.\nConcepts: KRAS NM 004985.3:c.37G>C (KRAS Exon 2 Mutation)\tproton-transporting ATP synthase, stator stalk (membrane protein complex)\tS1 (Heart Sounds)\tB6C3F1 (Mammal)\tBNIP3 (Gene or Genome)", + "output": "KRAS NM 004985.3:c.37G>C (KRAS Exon 2 Mutation)" + }, + { + "input": "Definition: something described as a fluorescence imaging agent composed of a fluorescent agent linked, via a human neutrophil elastase (HNE) cleavable peptide, to a dequencher molecule, with imaging activity for diagnostic purposes. Upon local administration, the neutrophil activation probe (NAP) imaging agent, initially quenched, is quickly taken up by activated neutrophils. In turn, the HNE expressed by these cells specifically cleaves the linker and dequenches the fluorescent agent. The activated fluorescent moiety allows for visualization of activated neutrophils and HNE activity upon using a fluorescence imaging device. Activated neutrophils are upregulated at sites of inflammation and in inflammation-induced cancers, and express high levels of HNE. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C126277\" active clinical trials using this agent.\nConcepts: United Kingdom English (Language)\tHospital Units; Epilepsy Unit (Manufactured Object)\tneutrophil activation probe imaging agent (Medicinal product acting as imaging agent)\tEOR01-Have You Vomited (EORTC QLQ-C30 Version 3 Questionnaire Question)\tAcral (Spatial pattern)", + "output": "neutrophil activation probe imaging agent (Medicinal product acting as imaging agent)" + }, + { + "input": "Definition: Neoplastic Process described as cancer has spread either (1) to the layer of fat outside the renal pelvis and/or ureter; or (2) into the wall of the kidney.\nConcepts: Material Description (Description)\tGrant Proposal (Application)\tBiological Rhythm and Oscillation (Physiological Processes)\t6 Minute Walk Functional Test Test Code (Intellectual Product)\tStage III Renal Pelvis and Ureter Carcinoma AJCC v7 (Renal Pelvis and Ureter Cancer by AJCC v7 Stage)", + "output": "Stage III Renal Pelvis and Ureter Carcinoma AJCC v7 (Renal Pelvis and Ureter Cancer by AJCC v7 Stage)" + }, + { + "input": "Definition: Structure of posterior lamella of eyelid described as the part of the conjunctiva that covers the inner surface of the eyelid.\nConcepts: ASSAY, PORPHYRIN, SPECTROPHOTOMETRY, LITHIUM (Medical Device)\tIVD Test Reagent/Kits, Clinical Chemistry, Protein, Total, Serum (IVD Test Reagent/Kits, Clinical Chemistry, Protein, Total)\tKinectin 1 (Kinesin Receptor) Gene (Gene or Genome)\tEuropean Union Drug Regulating Authorities Clinical Trials (Intellectual Product)\tTunica conjunctiva palpebrarum (Structure of conjunctival zone)", + "output": "Tunica conjunctiva palpebrarum (Structure of conjunctival zone)" + }, + { + "input": "Definition: Neoplastic disease described as a benign tumor derived from striated muscle. It is extremely rare, generally occurring in the tongue, neck muscles, larynx, uvula, nasal cavity, axilla, vulva, and heart. These tumors are treated by simple excision.\nConcepts: 45 (Brodmann area)\tRhabdomyoma, no ICD-O subtype (Myomatous neoplasm)\tPULMONARY EMPHYSEMAS (Diagnosis/Diseases Component)\tclustering of voltage-dependent sodium channels (Cell Function)\tbody physical activity (Organism Function)", + "output": "Rhabdomyoma, no ICD-O subtype (Myomatous neoplasm)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual vomited during the specified time period.\nConcepts: General Transcription Factor IIH Polypeptide 5 (Amino Acid, Peptide, or Protein)\tMPAI-4 - Adjustment: Sensitivity to Mild Symptoms (MPAI-4 Questionnaire Question)\tProminent frontal ridges (Congenital Abnormality)\tVomiting During This Period (Findings-Based Question)\tSore Throat brand (Organic Chemical)", + "output": "Vomiting During This Period (Findings-Based Question)" + }, + { + "input": "Definition: Carcinoma, Signet Ring Cell described as an invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate.\nConcepts: PWS (Laboratory Procedures)\tEssential Fatty Acid (Dietary Fats)\tSlender long bones with narrow shaft (Limb structure)\tCare coordinator (Administrative AND/OR managerial worker)\tColorectal Signet Ring Cell Carcinoma (Adenocarcinoma of large intestine)", + "output": "Colorectal Signet Ring Cell Carcinoma (Adenocarcinoma of large intestine)" + }, + { + "input": "Definition: Diagnostic Procedure described as screening is the process by which substances are evaluated in a battery of tests or assays (screens) designed to detect a specific biological property or activity. It can be conducted on a random basis in which substances are tested without any preselection criteria or on a targeted basis in which information on a substance with known activity and structure is used as a basis for selecting other similar substances on which to run the battery of tests.\nConcepts: N-terminal peptidyl-lysine N2-acetylation (N-terminal peptidyl-lysine acetylation)\tSomatotropin releasing factor-containing product (Hypothalamic Hormones)\tEccentric muscle contraction (Lengthening muscle contraction)\tThiethylperazine Maleate (Propylpiperazine derivative of phenothiazine)\tscreen/screening (Diagnostic Procedure)", + "output": "screen/screening (Diagnostic Procedure)" + }, + { + "input": "Definition: Cloaca Chamber described as the ventral compartment of the cloaca following its division from the urogenital septum; it will ultimately form the majority of the bladder, the entire urethra in females, part of the urethra in males, and the vestibule of the vagina in females.\nConcepts: UDP-glucose:trans-2-hydroxycinnamate O-beta-D-glucosyltransferase activity (phenol beta-glucosyltransferase activity)\tERT - Disgust Responded as Anger (Intellectual Product)\tUrogenital Sinus (Other Embryologic Structure)\tNITROSALICYLATE REDUCTION, AMYLASE (Indicator, Reagent, or Diagnostic Aid)\tPeptidyl Prolyl Cis Trans Isomerase C (Cyclophilins)", + "output": "Urogenital Sinus (Other Embryologic Structure)" + }, + { + "input": "Definition: something described as a general term for grouping human age group terms; prefer NTs.\nConcepts: AMYLASE (Hydrolase)\ttrabeculation (Organ or Tissue Function)\tage group (Persons)\tZinc Finger Protein Gli2 (Trans-Activators)\tScaphoid-Lunate-Capitate Joint (Wrist joint)", + "output": "age group (Persons)" + }, + { + "input": "Definition: Intellectual Product described as test names of questionnaire questions associated with the Pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Glove Boxes, Isolation/Containment (Glove Boxes)\tSloan Letter Eye Chart 100 Percent (Diagnostic Procedure)\tCDISC SDTM Device Events Action Taken with Device Terminology (CDISC SDTM Terminology)\tPediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version Questionnaire Test Name (CDISC Questionnaire Terminology)\tcyanate transmembrane transporter activity (Molecular Function)", + "output": "Pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version Questionnaire Test Name (CDISC Questionnaire Terminology)" + }, + { + "input": "Definition: Meningeal bacterial infections described as infections of the nervous system caused by bacteria of the genus HAEMOPHILUS, and marked by prominent inflammation of the MENINGES. HAEMOPHILUS INFLUENZAE TYPE B is the most common causative organism. The condition primarily affects children under 6 years of age but may occur in adults.\nConcepts: Grade 4 Treatment Related Secondary Malignancy, CTCAE (Treatment Related Secondary Malignancy, CTCAE)\tHaemophilus Meningitis (Disease or Syndrome)\tDNA hairpin binding (DNA secondary structure binding)\tSperm Aggregation (Laboratory Procedure)\tWnt signaling pathway, calcium modulating pathway (Molecular Function)", + "output": "Haemophilus Meningitis (Disease or Syndrome)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a non-specified caregiver other than nurse or physician service or procedure code. Use associated HCPCS II codes to bill for caregiver service(s). This code is used for scope-of-practice mapping, not for billing.\nConcepts: chalcone-flavanone isomerase activity (intramolecular lyase activity)\tPersonality Test (Diagnostic Procedure)\tdirty necrosis (Necrotic changes)\tNon-specified HCPCS II caregiver other than nurse or physician service or procedure reference code no charge (Tracking code use with or without ICD diagnosis)\tLatrodectus hasselti / black spider (Pharmacologic Substance)", + "output": "Non-specified HCPCS II caregiver other than nurse or physician service or procedure reference code no charge (Tracking code use with or without ICD diagnosis)" + }, + { + "input": "Definition: Finding During Childbirth Labor described as breaking or tearing of the amniotic membranes during childbirth leading to the leakage of amniotic fluid and the progression of labor.\nConcepts: Natural Rubber Latex Allergy (Immune system)\tregulation of L-methionine import across plasma membrane (Cell Function)\tRupture of fetal membranes (Finding During Childbirth Labor)\tTextus epithelialis (Epithelium)\tCSS03-Idea, Intent, No Plan-Life (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)", + "output": "Rupture of fetal membranes (Finding During Childbirth Labor)" + }, + { + "input": "Definition: Heart described as a ventricular septal defect that is confluent with and involves the membranous septum and is bordered by an atrioventricular valve, not including the type 3 VSDs.\nConcepts: Conoventricular ventricular septal defect (Ventricular Septal Defects)\tCampylobacter mustelae (Bacterium)\tNear point ruler (Medical Device)\tLoofah (Cucurbitaceae)\tLignans (Benzyl Compounds)", + "output": "Conoventricular ventricular septal defect (Ventricular Septal Defects)" + }, + { + "input": "Definition: something described as a type of clinical outcome assessment. A measurement based on a report that comes directly from the patient (i.e., study subject) about the status of a patient's health condition without amendment or interpretation of the patient's response by a clinician or anyone else. NOTE: A PRO can be measured by self-report or by interview provided that the interviewer records only the patient's response. Symptoms or other unobservable concepts known only to the patient can only be measured by PRO measures. PROs can also assess the patient perspective on functioning or activities that may also be observable by others.\nConcepts: More than 3 months ago (Temporal Concept)\tDressings, Impregnated, Petrolatum (Impregnated dressing)\tPatient-Reported Outcome (Self-Report)\tdental implant (Prosthesis)\tResponse, Adaptive Immune (Immune response)", + "output": "Patient-Reported Outcome (Self-Report)" + }, + { + "input": "Definition: something described as symptomatic; moderate decrease in visual acuity\nConcepts: {Cigar} (Potency Unit)\tGrade 2 Papilledema (Papilledema, CTCAE 5)\tSevere mental retardation (I.Q. 20-34) (Intellectual Disabilities)\tConfidence intervals (Statistics as Topic)\tLinea pectinata canalis analis (Anatomical line of anal canal)", + "output": "Grade 2 Papilledema (Papilledema, CTCAE 5)" + }, + { + "input": "Definition: Intellectual Product described as short-Form McGill Pain Questionnaire-2 test code.\nConcepts: trigeminal ganglia maturation (Organ or Tissue Function)\tresponse to p-xylene (response to xylene)\tCdc48p-Npl4p-Vms1p complex (outer mitochondrial membrane protein complex)\tCDISC Questionnaire Short-Form MPQ-2 Test Code Terminology (Intellectual Product)\tADCS-ADL MCI - Description of Usual Performance of Cleaning Room (ADCS-ADL MCI Questionnaire Question)", + "output": "CDISC Questionnaire Short-Form MPQ-2 Test Code Terminology (Intellectual Product)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a blood cell diluent is a device used to dilute blood for further testing, such as blood cell counting.\nConcepts: DILUENT, BLOOD CELL (Indicator, Reagent, or Diagnostic Aid)\tcerebellar molecular layer development (Organ or Tissue Function)\tHand Digit 3 Middle Phalanx (Body Part, Organ, or Organ Component)\tDelayed Release Granule for Suspension Dose Form (GRANULES, DELAYED RELEASE)\tcorticosteroid hormone secretion (steroid hormone secretion)", + "output": "DILUENT, BLOOD CELL (Indicator, Reagent, or Diagnostic Aid)" + }, + { + "input": "Definition: Liver and Intrahepatic Bile Duct Epithelial Neoplasm described as a non-metastasizing neoplasm that arises from the hepatocytes or intrahepatic bile ducts. Representative examples include hepatocellular adenoma and bile duct adenoma.\nConcepts: Hereditary anetoderma (Hereditary disorder of the integument)\tContracture of the metatarsophalangeal joint of the 3rd toe (Anatomical Abnormality)\tU4 snRNA 3' end processing (Genetic Function)\tDEVICE, VEIN STABILIZATION (Medical Device)\tBenign Liver and Intrahepatic Bile Duct Epithelial Neoplasm (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)", + "output": "Benign Liver and Intrahepatic Bile Duct Epithelial Neoplasm (Liver and Intrahepatic Bile Duct Epithelial Neoplasm)" + }, + { + "input": "Definition: Molecular Function described as any process that activates or increases the frequency, rate or extent of Fas signaling pathway.\nConcepts: LTZ/RAD (Regimen Used to Treat Endometrial Carcinoma)\tSCAR2 (Gene or Genome)\tlymphocyte migration into lymphoid organs (lymphocyte migration)\tmetanephric glomerular endothelium development (glomerular endothelium development)\tup regulation of Apo-1 signaling pathway (positive regulation of signal transduction)", + "output": "up regulation of Apo-1 signaling pathway (positive regulation of signal transduction)" + }, + { + "input": "Definition: Organic Chemical described as a methyl ester of methacrylic acid. Methyl methacrylate is a reactive resin, and the polymerized form is used as cement in dentistry, orthopaedic surgery and ophthalmology. The monomer form of this agent has relaxation effect on smooth muscle systemically, which might be a result of nitric oxide-mediated response.\nConcepts: Nasal Cavity and Ethmoid Sinus Cancer Pathologic Distant Metastasis TNM Finding v7 (Nasal Cavity and Ethmoid Sinus Cancer Pathologic TNM Finding v7)\tRIPK1 protein, human (Protein-Serine-Threonine Kinases)\tAdaptation (Adaptation)\tMethyl methacrylate-containing product (Acrylate and methacrylate patch test series - printing)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, DMPK (Medical Device)", + "output": "Methyl methacrylate-containing product (Acrylate and methacrylate patch test series - printing)" + }, + { + "input": "Definition: something described as represents a subdivision of the substantia nigra based on an alternate segmentation of that structure ( Francois-1984 ).\nConcepts: Ph Negative/BCR Positive (Laboratory or Test Result)\tNSAA107 (Intellectual Product)\tSubstantia nigra, pars reticulata (Body Part, Organ, or Organ Component)\tSubcortical heterotopia (Finding)\tUnknown Primary Tumor cN2 TNM Finding v8 (Finding)", + "output": "Substantia nigra, pars reticulata (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as a rare variant of mycosis fungoides, characterized by the development of folds of lax skin in the axillae or groins. It has been reported in association with Hodgkin lymphoma. Morphologically, there is a dense granulomatous dermal atypical lymphocytic infiltrate, often associated with multinucleated giant cells. Destruction of elastic tissue is present. Most cases have an indolent clinical course.\nConcepts: upregulation of epithelial cell proliferation (Stimulation of Cell Proliferation)\tHigh Shear Wet Milling Mixing (Mix)\tnegative regulation of triacylglycerol catabolic process (negative regulation of cellular catabolic process)\tGranulomatous slack skin disease (Atrophic condition of skin)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CLN3 (Medical Device)", + "output": "Granulomatous slack skin disease (Atrophic condition of skin)" + }, + { + "input": "Definition: Medical Device described as surgical calipers designed to measure the distance between two points of the eye during ophthalmic surgery procedures. These instruments are typically handheld, metallic, compasslike instruments with two adjustable, centrally hinged legs and either straight, angled, or curved sharp, rigid tips; the proximal end (i.e., the handle) usually includes a calibrated scale and a screw to adjust the separation of the legs (i.e., Castroviejo calipers, also used in other surgical procedures). Dedicated ophthalmic calipers are available that are articulated at the proximal end with a scale at the working end intended for cataract incision measurement (i.e., Osher calipers).\nConcepts: Intraductal Prostate Adenocarcinoma (Prostate cancer pathology)\tVol Dist Steady State Pred Norm by BMI (Predicted Steady State Volume of Distribution)\tOphthalmic Calipers, Surgical (Calipers, Surgical)\tPedsQL Neuromuscular Module Version 3.0 Child Report - Take Long Time to Eat (PedsQL Neuromuscular Module Version 3.0 Child Report Questionnaire Question)\tFeedback, Psychological (Psychological adjustment)", + "output": "Ophthalmic Calipers, Surgical (Calipers, Surgical)" + }, + { + "input": "Definition: CONSCIOUSNESS AND RELATED DISTURBANCES described as a state of depressed CENTRAL NERVOUS SYSTEM marked by stupor or insensibility.\nConcepts: Growth Factor, Fibroblast (Biologically Active Substance)\tnarcosis (Mental or Behavioral Dysfunction)\tMDA Autologous TILs (therapeutic autologous lymphocytes)\tUnresectable Rhabdomyosarcoma (Neoplastic Process)\tCorvus (Bird)", + "output": "narcosis (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: something described as this gene plays a role in proteasome assembly and localization.\nConcepts: Device Incorrectly Disinfected/Sterilized During Reprocessing (Functional Concept)\tProcessing Equipment (Instrument - device)\trecurrent adult diffuse small cleaved cell lymphoma (Neoplastic Process)\tECPAS Gene (Structural gene)\tInfantile Botulism (Congenital digestive system anomalies)", + "output": "ECPAS Gene (Structural gene)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of 18-methylnonadec-1-ene biosynthetic process.\nConcepts: ileum; fistula (Small bowel fistula)\tStudy Day of Food and Water Consumption (Study Day)\tregulation of 18-methylnonadec-1-ene anabolism (regulation of 18-methylnonadec-1-ene metabolic process)\tNonlytic Metastatic Lesion (Metastatic Lesion)\t6-benzyl-1-ethoxymethyl-5-isopropyluracil (Organic Chemical)", + "output": "regulation of 18-methylnonadec-1-ene anabolism (regulation of 18-methylnonadec-1-ene metabolic process)" + }, + { + "input": "Definition: Analgesics described as drugs used in combination with other pain drugs to assist or enhance their action.\nConcepts: Dextromethorphan product (ethyl ether)\tcoenzyme gamma-F420-2 biosynthesis (coenzyme gamma-F420-2 metabolic process)\tAdjuvant Medication (Pharmacologic Substance)\thistone demethylase activity (histone demethylase activity)\tAxis, Cervical Vertebra (Cervical spine)", + "output": "Adjuvant Medication (Pharmacologic Substance)" + }, + { + "input": "Definition: Hazardous or Poisonous Substance described as hydrazines substituted with two methyl groups in any position.\nConcepts: AV Block Second Degree M\u00f6bitz Type II (Disease or Syndrome)\tSulfone - chemical (Chemical categorized by structure)\tdown-regulation of antimicrobial peptide production (regulation of antimicrobial peptide production)\tDimethylhydrazines (Nitrogen Compounds, Unspecified)\tDry Powder Convection Mixing (Mix)", + "output": "Dimethylhydrazines (Nitrogen Compounds, Unspecified)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as left cardiac chamber which is continuous with the pulmonary venous trunk.\nConcepts: Surgical Retractor Kits, Spine, Cervical (Surgical Retractor Kits, Spine)\tCardiomyocyte mitochondrial proliferation (Abnormal cardiomyocyte morphology)\t2: 127581094-127521837 (Chromosome 2 Physical Location)\tLeft Atrium (Left atrial structure)\tData Defs Subcat (Intellectual Product)", + "output": "Left Atrium (Left atrial structure)" + }, + { + "input": "Definition: Cytoplasmic Vesicles described as a vesicle derived via budding from a mitochondrion. These vesicles often contain inner membrane and, much more rarely, cristae.\nConcepts: MDV (Cytoplasmic Vesicles)\tnegative regulation of plasma lipoprotein oxidation (regulation of plasma lipoprotein oxidation)\tGLMN Gene Product (Signaling Protein)\tanimal colony (Group)\tRespiratory System Findings Character Result in Standard Format (Character Result or Finding in Standard Format)", + "output": "MDV (Cytoplasmic Vesicles)" + }, + { + "input": "Definition: something described as depressors designed to displace the tongue by compression, facilitating the examination of the surrounding tissue in the oral cavity during examination. These instruments are typically handheld, slender and straight sticks or blades inserted in the mouth. Tongue examination depressors are usually disposable (i.e., single use) wooden or plastic sticks; less frequently, metal devices (blades) are available for repeated use after sterilization. Disposable sticks may also be used with specially designed stick holders that facilitate their manipulation without directly touching the stick; those holders may include an ejecting mechanism.\nConcepts: upregulation of mitotic DNA damage checkpoint (positive regulation of DNA damage checkpoint)\tCycloSPORINE (Amino Acid, Peptide, or Protein)\tOxidative Stress (Physiological Stress)\tTongue Sticks (Non-Measuring Instruments)\tcellular response to reactive nitrogen species (Cell Function)", + "output": "Tongue Sticks (Non-Measuring Instruments)" + }, + { + "input": "Definition: Beam modifier described as a diaphragm or system of diaphragms made of an absorbing material, designed to define and restrict the dimensions and direction of a beam of radiation.\nConcepts: Retinoblastoma H1 Finding v8 (Retinoblastoma Heritable Trait (H) Finding v8)\tinhibition of glutamate signalling pathway (Molecular Function)\tIVD Test Reagent/Kits, Serology, Virus, Parvovirus B19, IgM Antibody (Medical Device)\tHOXC Cluster Antisense RNA 4 (Non-Protein Coding) Gene (HOTAIR gene)\tCollimator (Device Component or Accessory)", + "output": "Collimator (Device Component or Accessory)" + }, + { + "input": "Definition: Cell described as an epithelial cell line initiated from a human bone metastasis of a grade IV prostatic ADENOCARCINOMA.\nConcepts: Anatomical point of head (Body Location or Region)\tPC-3 Cell (Epithelial Cells)\tLymphatic chain (Body Part, Organ, or Organ Component)\tsuprachiasmatic nucleus, ventrolateral region (Body Part, Organ, or Organ Component)\tHemolysis (Finding)", + "output": "PC-3 Cell (Epithelial Cells)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as a treatment being studied to improve brain function in certain brain disorders and in patients treated with chemotherapy for breast cancer. Sensors are placed on a person's head, which allows brain activity to be shown as patterns on a computer screen. A beep or a tone may be used as a reward to a person for changing certain brain activities. Neurofeedback may help cancer patients deal with the stress and mental side effects of chemotherapy.\nConcepts: biofeedback eeg (Therapeutic or Preventive Procedure)\tregulation of cyclic nucleotide gated ion channel activity (Biologic Function)\tHealth Care Provider Telecom Address (Intellectual Product)\tGrade 4 Constipation, CTCAE (Constipation, CTCAE)\taranea ixobola/cross spider (Pharmacologic Substance)", + "output": "biofeedback eeg (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Proxy - In the past 30 days, how much difficulty did your relative have in: Doing his or her most important work/school tasks well?\nConcepts: NTB-A (SLAMF6 gene)\tNeopulmonary valve regurgitation (Disease or Syndrome)\tWD6D5 6 (Intellectual Product)\tCell Differentiation Process (cell growth and differentiation)\tIncreased incisura length (Finding)", + "output": "WD6D5 6 (Intellectual Product)" + }, + { + "input": "Definition: Plasma membrane described as functionally and structurally differentiated, purple-pigmented regions of the cytoplasmic membrane of some strains of Halobacterium halobium. The membrane develops under anaerobic conditions and is made almost entirely of the purple pigment BACTERIORHODOPSINS.\nConcepts: Phosphoenolpyruvate Sugar Phosphotransferase System (Multienzyme Complexes)\tPurple Membranes (Plasma membrane)\tHeart Failure New/Worsening Lab Findings (Laboratory test finding)\tNasal Cavity and Ethmoid Sinus Cancer Pathologic Primary Tumor TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Pathologic TNM Finding v8)\tspray (Unit dose)", + "output": "Purple Membranes (Plasma membrane)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: a C-20 gibberellin + 2-oxoglutarate + O2 = a C-20 2-beta-hydroxygibberellin + succinate + CO2. C-20 gibberellin refers to a gibberellin with twenty carbons.\nConcepts: ADORA1 gene (G Protein-Coupled Receptor Genes)\tC-20 gibberellin 2-beta-hydroxylase activity (gibberellin 2-beta-dioxygenase activity)\tMo-molybdopterin cofactor catabolism (Molecular Function)\tput - instruction imperative (Instruction Imperative)\taethiops antimonialis/mercur (Homeopathic remedies letter A)", + "output": "C-20 gibberellin 2-beta-hydroxylase activity (gibberellin 2-beta-dioxygenase activity)" + }, + { + "input": "Definition: something described as renal segment supplied by the superior segmental branch of left renal artery.\nConcepts: Superior segment of left kidney (Body Part, Organ, or Organ Component)\tNOTCH, DROSOPHILA, HOMOLOG OF, 1 (Gene or Genome)\tCyclin-B2 (Amino Acid, Peptide, or Protein)\tAutosomal dominant Charcot-Marie-Tooth disease type 2Q (Autosomal dominant hereditary disorder)\tMethyltransferases (Enzyme)", + "output": "Superior segment of left kidney (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as unified Huntington's Disease Rating Scale '99 - Rigidity-arms, right.\nConcepts: Prolactin 16-kD Fragment (Endothelial Cell Inhibitor)\tCTA (Amino Acid, Peptide, or Protein)\tSuppliers; Medical Foods Supplier (Health Care Related Organization)\tIL-2 binding (Growth Factor Binding)\tUHDR109A (UHDRS 1999 Version Clinical Classification Question)", + "output": "UHDR109A (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: Cyst described as a cyst that is attached to the fallopian tube and originates from the remnants of the Mullerian duct.\nConcepts: Bending of the arm (Deformity of upper limb)\tIron-56 Ion Irradiation (high-LET heavy ion therapy)\tHealth Care Activity (Health)\tHydatid Cyst of Morgagni (Congenital Abnormality)\tlog10 PFU per Dose (Quantitative Concept)", + "output": "Hydatid Cyst of Morgagni (Congenital Abnormality)" + }, + { + "input": "Definition: Disorder of blood / lymphatics / immune system described as hemorrhagic and thrombotic disorders that occur as a consequence of abnormalities in blood coagulation due to a variety of factors such as COAGULATION PROTEIN DISORDERS; BLOOD PLATELET DISORDERS; BLOOD PROTEIN DISORDERS or nutritional conditions.\nConcepts: protein targeting to vacuolar membrane (Vacuolar Protein Sorting)\tCoagulation Disorders, Blood (CLOTTING DECREASED)\tEducation Level (Education and schooling detail)\tcardiac muscle hypertrophy in response to stress (muscle hypertrophy in response to stress)\tCD16 (Receptor Gene)", + "output": "Coagulation Disorders, Blood (CLOTTING DECREASED)" + }, + { + "input": "Definition: Finding described as esophagus and esophagogastric junction cancer with distant metastasis.\nConcepts: Small Cell Sarcomas (Sarcoma)\tEsophagus and Esophagogastric Junction Cancer cM1 TNM Finding v8 (Esophagus and Esophagogastric Junction Cancer Clinical Distant Metastasis TNM Finding v8)\tresponse to borneol (Organism Function)\tRetinoschisin Protein (Regulatory Protein)\tparsatuzumab (Antineoplastic Antibody)", + "output": "Esophagus and Esophagogastric Junction Cancer cM1 TNM Finding v8 (Esophagus and Esophagogastric Junction Cancer Clinical Distant Metastasis TNM Finding v8)" + }, + { + "input": "Definition: E [Preparations] described as a spironolactone derivative and selective ALDOSTERONE RECEPTOR antagonist that is used in the management of HYPERTENSION and CONGESTIVE HEART FAILURE, post-MYOCARDIAL INFARCTION.\nConcepts: 9,11alpha-epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester (E [Preparations])\tHyperostosis of craniofacial bones (Cranial hyperostosis)\tDilators, Lacrimal (Medical Device)\tFructosamine Corrected for Total Protein Measurement (Fructosamine measurement)\tLip and Oral Cavity Cancer cM0 TNM Finding v8 (Lip and Oral Cavity Cancer Clinical Distant Metastasis TNM Finding v8)", + "output": "9,11alpha-epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester (E [Preparations])" + }, + { + "input": "Definition: Bleeding tendency described as this term refers to an abnormally increased susceptibility to bruising (purpura, petechiae, or ecchymoses).\nConcepts: Bone Conduction (Musculoskeletal Physiological Processes)\tAnalyzers, Physiologic, Temperature/Base Screening (Medical Device)\themorrhage subcutaneous (Skin Diseases, Vascular)\tT cell receptor V(D)J joining (Genetic Function)\tEphedra sinica (Ephedra)", + "output": "hemorrhage subcutaneous (Skin Diseases, Vascular)" + }, + { + "input": "Definition: Yugoslavia described as created 7 April 1992 as a result of the division of Yugoslavia.\nConcepts: Dermatophytosis (Skin and subcutaneous tissue fungal infections)\tSLOVENIA (Yugoslavia)\tCatheter Related Infection (Infection associated with device)\tnegative regulation of axon regeneration (negative regulation of response to external stimulus)\tAbnormal osteoclast count (Anatomical Abnormality)", + "output": "SLOVENIA (Yugoslavia)" + }, + { + "input": "Definition: Intellectual Product described as european Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire - Core 30 Version 3.0 (EORTC QLQ-C30 Version 3) During the past week: Have you had diarrhea?\nConcepts: Used Quit Cigarette Smoking Books and/or Pamphlets (Finding)\tProstate Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma)\tBone Marrow Smear (Laboratory Procedure)\tDuchenne myodystrophy (Muscular Dystrophy)\tEOR0117 (Intellectual Product)", + "output": "EOR0117 (Intellectual Product)" + }, + { + "input": "Definition: something described as controllers designed to regulate high-pressure (e.g., up to several hundred psi/several thousand kPa) output of air and/or nitrogen gas lines from a single point. These controllers typically include one or more pressure gauges, a pressure regulator, valves, and a diameter indexed safety system (DISS) outlet, all enclosed in a cabinet-like container. An external panel with control knobs for the valves and pressure is attached to the container. The whole controller is either recessed in or mounted on a wall. Air/nitrogen pressure controllers are used for remote control of turbine-driven surgical tools and/or ceiling-mounted equipment (e.g., gas tracks, columns) in surgical rooms. They permit the user to make and break equipment connections at zero level pressure.\nConcepts: Nitrogen Control Cabinets (Controllers)\tAttribute in group cardinality (Cardinality - Reference set attribute)\tanti-FLT3 monoclonal antibody IMC-EB10 (Monoclonal Antibodies)\tthreonine-type peptidase activity (peptidase activity, acting on L-amino acid peptides)\tPrimary immune deficiency disorder, NOS (Genetic Diseases, Inborn)", + "output": "Nitrogen Control Cabinets (Controllers)" + }, + { + "input": "Definition: Virus Diseases described as an infection that is caused by one of two viruses: Variola major or Variola minor, both of which are transmitted via inhalation of droplets. A vaccine was developed, and smallpox was declared eradicated by the WHO in 1979.\nConcepts: Variola (Disease or Syndrome)\t2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase activity (Molecular Function)\tI 131 Lipiodol (ANTINEOPLASTIC RADIOPHARMACEUTICALS)\tsyringes (Equipment and Supplies)\tHyperactive (Chest Pain)", + "output": "Variola (Disease or Syndrome)" + }, + { + "input": "Definition: Population Group described as a healthy person volunteering to participate as a subject in a clinical study. NOTE: This is often a healthy person agreeing to participate in a Phase 1 trial. See also Phase 1.\nConcepts: Hydrochloride, Vancomycin (Amino Acid, Peptide, or Protein)\tAbnormal cardiomyocyte plakoglobin staining (Abnormal cardiomyocyte morphology)\tCK-20 (KRT20 gene)\tCytochrome P450, Family 2, Subfamily D, Polypeptide 6*17 Allele (CYP2D6 gene)\thealthy volunteer (Population Group)", + "output": "healthy volunteer (Population Group)" + }, + { + "input": "Definition: regulation of morphogenesis of an epithelium described as any process that modulates the frequency, rate or extent of imaginal disc-derived leg joint morphogenesis, the process in which the anatomical structure of the imaginal disc-derived leg joint is generated and organized.\nConcepts: Preneoplastic Conditions (Malignant Neoplasms)\tC3PAse (Enzyme)\tregulation of imaginal disc-derived leg joint morphogenesis (regulation of animal organ morphogenesis)\tComprehensive Dementia Gene Mutation Panel Reagents (Medical Device)\tTandem Repeat Variation (Mutation Abnormality)", + "output": "regulation of imaginal disc-derived leg joint morphogenesis (regulation of animal organ morphogenesis)" + }, + { + "input": "Definition: Adductor of hip joint described as a muscle in the lower extremity that adducts, flexes, and helps to rotate the thigh. It originates on the external surface of body of pubis and the anterior surface of the inferior pubic ramus and inserts in the pectineal line and the medial lip of the linea aspera. It is innervated by the anterior or posterior division of the obturator nerve and is supplied by the obturator and medial circumflex femoral arteries.\nConcepts: Nuclear Hormone Receptor NOR 1 (Orphan Nuclear Receptors)\trubrospinal tract of the hindbrain (Body Part, Organ, or Organ Component)\tAdductor brevis (Muscle of medial compartment of thigh)\tOvarian Endometrioid Stromal and Related Neoplasms (Neoplastic Process)\tAbnormality of the carotid arteries (Abnormal systemic arterial morphology)", + "output": "Adductor brevis (Muscle of medial compartment of thigh)" + }, + { + "input": "Definition: Animal oil described as an oily substance taken from sheep's wool. Lanolin is used in moisturizing creams and lotions to treat dry, itchy skin.\nConcepts: 10: 203334234-203329343 (Spatial Concept)\tnew hmvst 20min (Therapeutic or Preventive Procedure)\tVascular Endothelial Growth Factor, Endocrine Gland Derived (Vascular Endothelial Growth Factors)\tRefractory Malignant Thymoma (Malignant Thymoma)\tWool oil (Organic Chemical)", + "output": "Wool oil (Organic Chemical)" + }, + { + "input": "Definition: Neoplastic Process described as a carcinoma that arises from a pleomorphic adenoma in the salivary glands. It usually originates in the parotid gland. Patients usually present with a history of a long-standing tumor mass which grew rapidly in the past few months. Patients with non-invasive or minimally invasive carcinoma have an excellent prognosis. In cases where there is invasion of the surrounding tissues, the clinical course is aggressive.\nConcepts: CANNULA,OPHTHALMIC,POSTERIOR CAPSULAR POLISHING,POLYVINYL ACETAL (Medical Device)\tFAM135B (Gene or Genome)\tSalivary Gland Carcinoma ex Pleomorphic Adenoma (Carcinoma ex pleomorphic adenoma)\tdCDP anabolism (dCDP metabolic process)\tPharmaceutical Product Characteristics (Medical Product Characteristics)", + "output": "Salivary Gland Carcinoma ex Pleomorphic Adenoma (Carcinoma ex pleomorphic adenoma)" + }, + { + "input": "Definition: something described as cartridge syringes that are designed to resemble a standard ball-point pen and are used to inject insulin from prefilled disposable cartridges (e.g., 1 to 3 mL capacity). These syringes are typically reusable metallic devices that include a dial for accurate selection of the appropriate dose and a button for injection.\nConcepts: Jaw hyporeflexia (Decreased tendon reflex)\tSyringes, Cartridge, Insulin, Penlike (Syringes, Cartridge, Insulin)\tMedical Information Exchanges (Health Care Activity)\tECGELCTN (Numbers)\tMoraxella kingae (Moraxella )", + "output": "Syringes, Cartridge, Insulin, Penlike (Syringes, Cartridge, Insulin)" + }, + { + "input": "Definition: Device Component or Accessory described as a device designed to hold something in place.\nConcepts: Monitors, Physiologic, Respiration, Ventilation/Apnea, Bedside/Intraoperative (Medical Device)\tParticipating Country Code (Intellectual Product)\tMetastatic Squamous Cell Breast Carcinoma (Squamous cell carcinoma, metastatic)\tFastener Device (Manufactured Object)\tMIZ1 (Transcription Regulation Gene)", + "output": "Fastener Device (Manufactured Object)" + }, + { + "input": "Definition: something described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Self - Because of your health condition, in the past 30 days, how much difficulty did you have in: Getting all the work done that you need to do?\nConcepts: geriatric dentistry (Dentistry)\tinositol-1-kinase (kinase activity)\tFc receptor-like 1, human (Receptor)\tcarbon C 11 N-desmethyl-loperamide (Indicator, Reagent, or Diagnostic Aid)\tWHODAS 2.0 36-item Version Self-administered - Getting All Work Done You Need (Intellectual Product)", + "output": "WHODAS 2.0 36-item Version Self-administered - Getting All Work Done You Need (Intellectual Product)" + }, + { + "input": "Definition: Drugs used to treat addiction described as group of agents used as alcoholism deterrents, either by causing unpleasant symptoms when ethanol is ingested or as aids in withdrawal or maintenance of abstinence.\nConcepts: Stage IVB Lip and Oral Cavity Cancer (Neoplastic Process)\tAlcohol Deterrents (antagonists & inhibitors)\tCDISC Questionnaire C-SSRS Lifetime/Recent Version Test Code Terminology (Intellectual Product)\tHow Often Have Sexual Thoughts or Fantasies While Awake (Clinical or Research Assessment Question)\tBRCA Mutation Status (Laboratory Procedure)", + "output": "Alcohol Deterrents (antagonists & inhibitors)" + }, + { + "input": "Definition: Physical activity described as the act of raising something.\nConcepts: IPA0323B (Intellectual Product)\tLifting (General purpose physical activity)\tNecrosis, Avascular, of Bone (non-articular bone disorders)\tENTACTIN (NID1 gene)\tSpecimen treatments (Health Care Activity)", + "output": "Lifting (General purpose physical activity)" + }, + { + "input": "Definition: Fatigable weakness of bulbar muscles described as a type of weakness of the muscles involved in chewing that occurs after a muscle group is used and lessens if the muscle group has some rest. That is, there is diminution of strength with repetitive muscle actions.\nConcepts: lacosamide (Acetamides)\tFatigable weakness of chewing muscles (Finding)\tVesical trigone (Body Location or Region)\tdorsomedial periaqueductal gray (Central gray substance of midbrain)\tup-regulation of pentadecane metabolic process (regulation of pentadecane metabolic process)", + "output": "Fatigable weakness of chewing muscles (Finding)" + }, + { + "input": "Definition: Mycosis fungoides/Sezary syndrome stage IV described as stage IV includes: IVA1 (T1-4, N0-2, M0, B2); IVA2 (T1-4, N3, M0, B0-2); IVB (T1-4, N0-3, M1, B0-2). T1: Limited patches, papules, and/or plaques covering less than 10% of the skin surface. May further stratify into T1a (patch only) vs. T1b (plaque +/- patch). T2: Patches, papules, or plaques covering 10% or more of the skin surface. May further stratify into T2a (patch only) vs. T2b (plaque +/- patch). T3: One or more tumors (equal or greater than 1 cm diameter). T4: Confluence of erythema covering 80% or more of body surface area. N0: No clinically abnormal peripheral lymph nodes; biopsy not required. N1: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 1 or NCI LN0-2. N2: Clinically abnormal peripheral lymph nodes; histopathology Dutch grade 2 or NCI LN3. N3: Clinically abnormal peripheral lymph nodes; histopathology Dutch grades 3-4 or NCI LN4; clone positive or negative. M0: No visceral organ involvement. M1: Visceral involvement (must have pathology confirmation and organ involved should be specified). B0: Absence of significant blood involvement: 5% or less of peripheral blood lymphocytes are atypical (Sezary cells). B1: Low blood tumor burden: more than 5% of peripheral blood lymphocytes are atypical (Sezary cells) but does not meet the criteria of B2. B2: High blood tumor burden: 1000/microL Sezary cells or more with positive clone.\nConcepts: Interleukin-11 Receptors (Receptor)\traisin flavor (Structured Product Labeling Flavor)\tPREAMPLIFIER, AC-POWERED, OPHTHALMIC (Medical Device)\tDOPAC (Laboratory Procedure)\tMycosis Fungoides Stage IV (Neoplastic Process)", + "output": "Mycosis Fungoides Stage IV (Neoplastic Process)" + }, + { + "input": "Definition: Fracture Fixation described as immobilization of a dislocated lower extremity.\nConcepts: Stabilize Lower Extremity Fracture (Fracture Fixation)\t(ml/d)/(ug/kg) (Unit of Dose Calculation)\tSGRQ02-Unpleasant Side Effect From Med (Intellectual Product)\texocytic vesicle membrane (Cell Component)\tBioterrorism (Biological Warfare)", + "output": "Stabilize Lower Extremity Fracture (Fracture Fixation)" + }, + { + "input": "Definition: Social Behavior described as organizations and individuals cooperating together toward a common goal at the local or grassroots level.\nConcepts: (3S)-(+)-asterisca-2(9),6-diene synthase activity (sesquiterpene synthase activity)\tIntergroup Rhabdomyosarcoma Clinical Grouping System (Intellectual Product)\tPerformed Activity Study Day Range (Study Day Range)\tCommunity Network (Community Health Services)\tTuberculum quadrigeminus (Body Part, Organ, or Organ Component)", + "output": "Community Network (Community Health Services)" + }, + { + "input": "Definition: Phenanthrenes described as narcotic analgesic related to CODEINE, but more potent and more addicting by weight. It is used also as cough suppressant.\nConcepts: Cortexolone (Steroids)\tBlood-Aqueous Barriers (Cardiovascular system)\tCYP1A2, wild-type (Gene or Genome)\tHidrocodona (Opium alkaloids and derivatives, cough suppressants)\tReceive Counseling (Risk Evaluation and Mitigation Strategies Requirement)", + "output": "Hidrocodona (Opium alkaloids and derivatives, cough suppressants)" + }, + { + "input": "Definition: creating order described as a cognitive process involving the formation of ideas generalized from the knowledge of qualities, aspects, and relations of objects.\nConcepts: Blind--Education (Educational Activity)\tDominant beta-thalassemia (Autosomal dominant hereditary disorder)\tLactose, Unspecified form (Sugars/Sugar metabolism)\tLANOLIN (Organic Chemical)\tConcept Formation (Cognitive functions)", + "output": "Concept Formation (Cognitive functions)" + }, + { + "input": "Definition: Cell Function described as any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.\nConcepts: Segmenta coccygea (Segment of spinal cord)\tpositive regulation of cell morphogenesis involved in differentiation (Cell Function)\tresponse to starvation (response to nutrient levels)\tCRUSHER, SPUR, COLOSTOMY (Medical Device)\tNeonatal bilateral symmetric epileptic spasm (Neonatal epileptic spasm)", + "output": "positive regulation of cell morphogenesis involved in differentiation (Cell Function)" + }, + { + "input": "Definition: Finding described as EEG shows spikes (<80 ms) and waves, which are recorded over the entire scalp and do not have a specific frequency.\nConcepts: Alcohol Drinking Habit (Level of fear: child)\tPDA synthase activity (Molecular Function)\tR-linalool synthase activity (Molecular Function)\tEEG with irregular generalized spike and wave complexes (Finding)\tBehavior modification assist (mental health counseling)", + "output": "EEG with irregular generalized spike and wave complexes (Finding)" + }, + { + "input": "Definition: Finding described as a pattern or manner of running, walking, or moving on foot.\nConcepts: Palsy, Dejerine-Klumpke (Lower Brachial Plexus Neuropathy)\tFree and Sovereign State of Sinaloa (Mexican State)\tPLCA1 (Gene or Genome)\tRIalpha, cAMP Protein Kinase (Cyclic AMP-Dependent Protein Kinase Type I)\tManner of walking (chordate locomotion)", + "output": "Manner of walking (chordate locomotion)" + }, + { + "input": "Definition: something described as receptor-type tyrosine-protein phosphatase T (1441 aa, ~162 kDa) is encoded by the human PTPRT gene. This protein is involved in cell-cell adhesion, signal transduction and protein dephosphorylation.\nConcepts: sensory system development (system development -- biological)\tLPS Adsorbers, Extracorporeal (Device Labeled for Single Use)\tc-erbB1 Gene Amplification (Receptor Tyrosine Kinase Gene Amplification)\tSouthwest (Spatial Concept)\tReceptor-Type Tyrosine-Protein Phosphatase T (Protein Tyrosine Phosphatase)", + "output": "Receptor-Type Tyrosine-Protein Phosphatase T (Protein Tyrosine Phosphatase)" + }, + { + "input": "Definition: something described as RAPID3 weighted score = 1.3-2.0\nConcepts: CSS02-Number of Interrupted Attempts (C-SSRS Since Last Visit Questionnaire Question)\tbutyryl-CoA synthetase activity (Molecular Function)\tLow severity (Finding)\tOptic Atrophy Gene Mutation Panel Reagents (Medical Device)\tbenzil reductase [(S)-benzoin-forming] activity (Molecular Function)", + "output": "Low severity (Finding)" + }, + { + "input": "Definition: Laboratory Procedure described as method of preferential labeling of specific binding molecules or sites in a mixture by coupling the label to the corresponding ligand; e.g., enzyme labeling by reactive dyes coupled to substrate.\nConcepts: affinity labeling (Laboratory Procedure)\tCell-Matrix Adherens Junction (Focal Adhesions)\tCranberry Flavor (Food)\tIVD Test Reagent/Kits, Serology, Virus, Hepatitis A, Antibody (IVD Test Reagent/Kits, Serology, Virus, Hepatitis A)\tIntraocular Fluid (Body Substance)", + "output": "affinity labeling (Laboratory Procedure)" + }, + { + "input": "Definition: something described as automation systems designed to control multiple operating-room devices via a common interface. These systems typically consist of a combination of hardware and software that includes a networked computerized control system through which information and images can be directed, a user interface (e.g., touchscreens, voice control) to perform functions (e.g., issuing commands, routing data and video), surgical and ancillary devices (e.g., electrosurgical units, lights, endoscopic devices) that share a common communication protocol and that are integrated into the system, and local endoscopic and operating-room video systems. Some systems only network devices located within the operating room (i.e., stand-alone systems); other systems can communicate with information and image systems outside the operating room (e.g., hospital and/or radiology information systems). Operating-room automation systems are intended to improve the ergonomy, safety, and efficiency of surgical procedures, particularly during minimally invasive surgery; they are usually configured according to particular surgical requirements.\nConcepts: Trephines, Surgical, Eye, Lacrimal (Medical Device)\tLactobacillus sakei (Lactobacillus)\tSurgical Automation Systems (Medical Device)\tpositive regulation of optic nerve formation (regulation of optic nerve formation)\tHOSP SPECIAL (Hospitals)", + "output": "Surgical Automation Systems (Medical Device)" + }, + { + "input": "Definition: Central Nervous System described as intermittent pain, i.e., pain that occurs occasionally and at irregular intervals. []\nConcepts: TSCYC1-Not Noticing What He or She Doing (TSCYC Questionnaire Question)\tNor\u00e9pin\u00e9phrine (Pharmacologic Substance)\tGrade 3 Gastric Perforation, CTCAE (Gastric Perforation, CTCAE 5)\tExhibition Booths (Casework and Furniture)\tEpisodic pain (Central Nervous System)", + "output": "Episodic pain (Central Nervous System)" + }, + { + "input": "Definition: Fruit, Citrus described as the sour to semi-sweet fruit of Citrus x paradisi. Grapefruit can have interactions with drugs, often increasing the effective potency of compounds.\nConcepts: grapefruit (Fruit, Citrus)\tCCQ0205 (Intellectual Product)\tCyclin E Destruction Pathway (Degradation Pathway)\thydroxymethylmethylsilanediol oxidase activity (oxidoreductase activity, acting on CH-OH group of donors)\tMottled coloration (Color finding)", + "output": "grapefruit (Fruit, Citrus)" + }, + { + "input": "Definition: Gene or Genome described as this gene may play a role in the negative regulation of gene transcription.\nConcepts: urine (metabolic aspects)\tGON4L gene (Gene or Genome)\tcarrageenan (Plant Extracts)\tFocal impaired awareness perseverative automatism seizure (Disease or Syndrome)\tL-ornithine transmembrane transport (L-alpha-amino acid transmembrane transport)", + "output": "GON4L gene (Gene or Genome)" + }, + { + "input": "Definition: Pharmacologic Substance described as the 11-residue peptide that is fully amidated.\nConcepts: Bilayer, Lipid (Membranes, Artificial)\tgamma1-MSH (Pharmacologic Substance)\tUterine Corpus Endometrial Stromal and Related Tumors (Uterine Corpus Soft Tissue Neoplasm)\tCSS05-Most Lethal Attempt Date (C-SSRS Already Enrolled Subjects Questionnaire Question)\tStructured Product Labeling Potency Terminology (Intellectual Product)", + "output": "gamma1-MSH (Pharmacologic Substance)" + }, + { + "input": "Definition: Naevi, hamartomas and developmental anomalies described as a common hemangioma characterized by the presence of capillary-sized vascular channels without prominent epithelioid endothelial cells.\nConcepts: counseling about nutrition using relapse prevention strategy (Therapeutic or Preventive Procedure)\tMark;strawberry (Mass of body structure)\tTc99m MOAB 170 (Amino Acid, Peptide, or Protein)\tTrichoblastic Carcinosarcoma (Neoplastic Process)\tVAS (Intellectual Product)", + "output": "Mark;strawberry (Mass of body structure)" + }, + { + "input": "Definition: SGRQ-C Questionnaire Question described as st. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) We would like to know how your respiratory problems usually affect your daily life: I cannot play sports or do other physical activities.\nConcepts: Ulcerative Colitis-Associated Colorectal Carcinoma (Neoplastic Process)\tSGRQC136 (SGRQ-C Questionnaire Question)\tTumor of Skin Appendage (Disorder of integument)\tcellular response to interleukin-8 (cellular response to cytokine stimulus)\tAbandoned children (Persons)", + "output": "SGRQC136 (SGRQ-C Questionnaire Question)" + }, + { + "input": "Definition: Mental or Behavioral Dysfunction described as a reduced ability to participate in the back and forth flow of social interaction, which is normally characterized by an influence of the behavior of one person on the behavior of another person who is in conversation with the first.\nConcepts: 3-Dimensional Ultrasound Mode (Ultrasound Mode)\tPosterior Innominate Rotation (Pathologic Function)\tImpaired social reciprocity (Mental or Behavioral Dysfunction)\tRegular Smokeless Tobacco Use for Six Weeks or More (CPTAC Questions)\tVANDORTUZUMAB VEDOTIN (Immunotoxins)", + "output": "Impaired social reciprocity (Mental or Behavioral Dysfunction)" + }, + { + "input": "Definition: Hormonal Change described as any process in which the monoamine neurohormone dopamine is released from the arcuate nucleus of the hypothalamus and binds to receptors in the anterior pituitary, resulting in inhibition of secretion of prolactin. This process is involved in terminating the production of milk once lactation is complete.\nConcepts: TRANSMEMBRANE AND COILED-COIL DOMAIN FAMILY, MEMBER 1 (Genes, Regulator)\tGrade 2 Uterine anastomotic leak (Finding)\tAbnormal morphology of the great vessels (Anatomical Abnormality)\tAxitinib Regimen (Therapeutic or Preventive Procedure)\tProlactin Inhibiting Factor Activity Alteration (Physiologic Function)", + "output": "Prolactin Inhibiting Factor Activity Alteration (Physiologic Function)" + }, + { + "input": "Definition: Laboratory and/or office procedures described as branch of medicine that deals with the use of radiant energy including X rays, gamma rays, radiowaves, high frequency sound waves in the diagnosis and treatment of disease; for thorough searching see RT's.\nConcepts: medial preoptic area proper (Body Location or Region)\tAppendix (abdominal organ)\tpyogenes s. (Streptococcus)\tRADIOL (Biomedical Occupation or Discipline)\tgp100-Fowlpox Vaccine (Immunologic Factor)", + "output": "RADIOL (Biomedical Occupation or Discipline)" + }, + { + "input": "Definition: Regimen Used to Treat Colorectal Carcinoma described as a chemoimmunotherapy regimen consisting of irinotecan and ramucirumab that is used for the treatment of colon cancer.\nConcepts: PUL01-Stacking Heavy Cans (PUL 1.2 Functional Test Question)\tIrinotecan-Ramucirumab (Regimen Used to Treat Colorectal Carcinoma)\tIncreased level of N-benzoylglycine in blood (Abnormal circulating carboxylic acid concentration)\tCandida boidinii C. Ramirez, 1953 (Fungus)\tVFQ114 (VFQ25-Interviewer Administered Format Questionnaire Question)", + "output": "Irinotecan-Ramucirumab (Regimen Used to Treat Colorectal Carcinoma)" + }, + { + "input": "Definition: Enzymes, antithrombotic described as a tissue plasminogen activator enzyme that acts as a fibrinolytic agent; it is used for the dissolution of blood clots, such as those that occur in acute MYOCARDIAL INFARCTION.\nConcepts: Omotracheal triangle (Anterior triangle of neck)\tAlternate Protocol Identifier (Intellectual Product)\t3 OF 4 (Clinical or Research Assessment Answer)\tTenecteplase-containing product (Enzymes, antithrombotic)\t1-Naphthacenecarboxylic acid, 4-[[O-2,6-dideoxy-.alpha.-L-lyxo-hexopyranosyl-(1.fwdarw.4)-O-2, 6-dideoxy-.alpha.-L-lyxo-hexopyranosyl-(1.fwdarw.4)-2,3, 6-trideoxy-3-(dimethylamino)-.alpha.-L-lyxo-hexopyranosyl]oxy]-2-e thyl-1,2,3,4,6,11-hexahydro-2,5,7,10-tetrahydroxy-6,11-dioxo-, methyl ester, (1R-(1.alpha.,2.beta.,4.beta.))- (Antibiotic)", + "output": "Tenecteplase-containing product (Enzymes, antithrombotic)" + }, + { + "input": "Definition: something described as a series of sequential, propagated action potentials occurring in a single cell.\nConcepts: burst of action potentials (regulation of membrane potential)\tMRS - Modified Rankin Scale Score (MRS Questionnaire Question)\tStudy Protocol Version Amendment Grace Period (Temporal Concept)\tGrade 3 (Finding)\tacetyl-CoA:corrinoid protein O-acetyltransferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)", + "output": "burst of action potentials (regulation of membrane potential)" + }, + { + "input": "Definition: something described as smallest unit of information in a transaction. [From body and glossary of FDA Final Guidance on eSource] See also eXtensible markup language (XML) data element, common data element, clinical study data element.\nConcepts: Behavioral Health & Social Service; Psychologist; Forensic (Professional or Occupational Group)\tData Element (Intellectual Product)\tExpanded DRS-PI Survivor Version - Successful With Accommodations (Intellectual Product)\tStage III Grade II Follicular Lymphoma (Stage III Indolent Adult Non-Hodgkin Lymphoma)\tMulticentric Papillary Thyroid Gland Carcinoma (Neoplastic Process)", + "output": "Data Element (Intellectual Product)" + }, + { + "input": "Definition: something described as a form of beta-thalassemia characterized by splenomegaly and petechiae, moderate thrombocytopenia, prolonged bleeding time due to platelet dysfunction, reticulocytosis and mild beta-thalassemia. Prevalence of this form is not known. The disorder is not associated with mutations in the HBB gene (11p15.5), but with mutations in the gene encoding GATA-binding protein-1 (GATA1; Xp11.23) that result in reduced expression of the beta-globin genes. Transmission is X-linked.\nConcepts: Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 (Neoplastic Process)\tVasodilator-Stimulated Phosphoprotein wt Allele (VASP gene)\tBeta thalassaemia X-linked thrombocytopenia syndrome (beta Thalassemia)\tRare Disease Indicator (Indicator)\tNCCN-FACT FBLSI-18 Version 2 - I Feel Weak All Over (Intellectual Product)", + "output": "Beta thalassaemia X-linked thrombocytopenia syndrome (beta Thalassemia)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in transcriptional regulation.\nConcepts: activates (Action)\tEOR0104 (EORTC QLQ-C30 Version 3 Questionnaire Question)\tCYCLIN-DEPENDENT KINASE 8 (Mediator Complex Component Gene)\tiPSC-derived NK Cells FT500 (Allogeneic Lymphocyte)\tCarbon-sulfur lyase (Molecular Function)", + "output": "CYCLIN-DEPENDENT KINASE 8 (Mediator Complex Component Gene)" + }, + { + "input": "Definition: Finding described as bending or curvature of a thumb towards the ulnar side (towards the ring finger).\nConcepts: Ulnar deviation of thumb (Ulnar deviation of the fingers)\tCDC37 homolog protein (Molecular Chaperones)\tDigital Content (Contents)\tBlood Viscosity (Physiologic Function)\tIntraocular Route of Administration (RouteBySite)", + "output": "Ulnar deviation of thumb (Ulnar deviation of the fingers)" + }, + { + "input": "Definition: therapeutic autologous lymphocytes described as a preparation of autologous T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR autologous T-lymphocytes specifically target and bind to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed in normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation.\nConcepts: Soft Tissue Sarcoma by AJCC v7 Stage (Neoplastic Process)\tAnimal.strain (Organism)\tGPC3-targeted CAR Autologous T Cells (Antineoplastic Immune Cell)\tcough symptoms (Respiration Disorders)\tMoloney murine sarcoma virus MuSV (Murine leukemia virus)", + "output": "GPC3-targeted CAR Autologous T Cells (Antineoplastic Immune Cell)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 4-hydroxy-L-threonine <=> glycolaldehyde + glycine.\nConcepts: 4-hydroxy-L-threonine aldolase activity (aldehyde-lyase activity)\tFAC036-I Am Sleeping Well (Intellectual Product)\tFrontal fibrosing alopecia (Eczema of scalp)\tNucleotide Deaminases (Aminohydrolases)\tBreath Holding (Respiration Alteration)", + "output": "4-hydroxy-L-threonine aldolase activity (aldehyde-lyase activity)" + }, + { + "input": "Definition: Gene or Genome described as human FCHSD1 wild-type allele is located in the vicinity of 5q31.3 and is approximately 12 kb in length. This allele, which encodes F-BAR and double SH3 domains protein 1, may play a role in signaling.\nConcepts: Diphosphokinases, Nucleoside (Amino Acid, Peptide, or Protein)\tVicodin (Organic Chemical)\tEthics, Clinical (Ethics, Professional)\tNervous Wreck Homolog 2 Gene (FCHSD1 gene)\tmemory intervention (Health Care Activity)", + "output": "Nervous Wreck Homolog 2 Gene (FCHSD1 gene)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as cysteinyl-tRNA synthetase, cytoplasmic (748 aa, ~85 kDa) is encoded by the human CARS1 gene. This protein is involved in tRNA aminoacylation.\nConcepts: desiccated thyroid gland (Animal-based Natural Product)\tGuanylate Binding Protein 2 Measurement (Protein or Enzyme Type Measurement)\tColon Kaposi Sarcoma (Colorectal Kaposi Sarcoma)\tCerebellar hemisphere, NOS (Body Part, Organ, or Organ Component)\tCysteinyl-tRNA Synthetase, Cytoplasmic (Ligase)", + "output": "Cysteinyl-tRNA Synthetase, Cytoplasmic (Ligase)" + }, + { + "input": "Definition: Protein Kinase Inhibitors described as a synthetic small molecule inhibitor of checkpoint kinases (Chks) with potential chemosensitizing activity. AZD7762 binds to and inhibits Chks, which may prevent cell cycle arrest and subsequent nucleotide excision repair in DNA-damaged tumor cells, resulting in tumor cell apoptosis. This agent may enhance the cytotoxicity of DNA-damaging agents. Chks are protein kinases that regulate either G1/S or G2/M transitions in the cell cycle. In the presence of DNA damage or incomplete DNA replication, Chks become activated and initiate cell cycle arrest to allow DNA repair or the completion of DNA replication.\nConcepts: Prominence of the primary palate bone (Finding)\tDendritic Cells (Epithelial Cells)\tdynein complex binding (Molecular Function)\tAZD7762 (Organic Chemical)\tSelf-Esteem (Intellectual Product)", + "output": "AZD7762 (Organic Chemical)" + }, + { + "input": "Definition: Neoplastic Process described as tumors of bone tissue or synovial or other soft tissue characterized by the presence of giant cells. The most common are giant cell tumor of tendon sheath and GIANT CELL TUMOR OF BONE.\nConcepts: RP3-468K18.1 (Gene or Genome)\toligodendrocyte cell fate commitment (oligodendrocyte differentiation)\trRNA transcription from plastid promoter (rRNA transcription)\tGiant cell tumor NOS (Neoplasms, Connective Tissue)\tBenign Neoplasm of the Maxillofacial Sinus (Maxillary Sinus Neoplasms)", + "output": "Giant cell tumor NOS (Neoplasms, Connective Tissue)" + }, + { + "input": "Definition: something described as some matter, situation, or event that is thought about, written about, or discussed.\nConcepts: Subject - topic (Conceptual Entity)\tKi (Quantitative Concept)\tPedsQL Neuromuscular Module Acute Version 3.0 Teen Report - Do Not Have Equipment Need (PedsQL Neuromuscular Module Acute Version 3.0 Teen Report Questionnaire Question)\tMelphalan Hydrochloride (Carcinogens)\tUterine Corpus Adenosarcoma FIGO Stage IA (Uterine Corpus Adenosarcoma pT1 TNM Finding v8)", + "output": "Subject - topic (Conceptual Entity)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a fiber pathway from the cerebral cortex to the spinal cord. Its fibers originate from pyramidal neurons of the precentral gyrus, and on their way to the spinal cord, pass through parts of the cerebral white matter (including the posterior limb of the internal capsule), the crus cerebri, the longitudinal pontine fibers, the pyramid of the medulla (where they are known as the pyramidal tract) and the pyramidal decussation. In the ducussation, some fibers cross to the other side of the brainstem to form the lateral corticospinal tract. Those fibers that do not cross split to form the anterolateral corticospinal tract and the anterior corticospinal tract ( Carpenter-1983 ). Some parts of the tract are not readily distinguished in myelin stained cross-sections.\nConcepts: G protein-coupled nucleotide receptor binding (Molecular Function)\tCorticospinal Tracts (lateral forebrain bundle system)\tHead and Neck Cancer pN3a TNM Finding v8 (Head and Neck Cancer pN3 TNM Finding v8)\tCDHP (Pharmacologic Substance)\tPKM wt Allele (PKM gene)", + "output": "Corticospinal Tracts (lateral forebrain bundle system)" + }, + { + "input": "Definition: Round Cell Liposarcoma described as round cell liposarcoma that has spread to other anatomic sites.\nConcepts: Follicular Lymphoma International Prognostic Index Score 2 (Follicular Lymphoma International Prognostic Index)\tMetastatic Round Cell Liposarcoma (Neoplastic Process)\tConditioned stimulus, function (Conditioning and Stimulus Functions and Disorders)\tCCR6 Receptors (CCR Receptors)\tregulation of microvillus organisation (Cell Function)", + "output": "Metastatic Round Cell Liposarcoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as a sports chiropractor is uniquely trained to provide care and treatment of injuries or illness resulting from sports and physical fitness activities. Doctors of Chiropractic with the Diplomate American Chiropractic Board of Sports Physicians (DACBSP) or the Certified Chiropractic Sports Physician (CCSP), sport specialty certifications from the American Chiropractic Board of Sports Physicians, have advanced training in the assessment, management and rehabilitation of sports related injuries. Extremity care, rehabilitation and soft tissue procedures are common skills utilized by these doctors. The specialty training covers a broad spectrum from the pediatric athlete to professional and Olympic athletes, and everything in between, using a variety of techniques and modalities.\nConcepts: COSTOCHONDRAL JUNCTION ENLARGEMENT (Finding)\tpyridine nucleoside synthesis (pyridine nucleoside metabolic process)\tIPAQ Long Last 7 Days Self-Administered Format Version - No Vigorous Job-related Activity (Intellectual Product)\tChiropracters; Chiropractor; Sports Physician (Professional or Occupational Group)\tBacillus Calmette-Guerin Tokyo-172 Strain Solution (Pharmacologic Substance)", + "output": "Chiropracters; Chiropractor; Sports Physician (Professional or Occupational Group)" + }, + { + "input": "Definition: Guidelines described as a modified guide to the fundamental elements of data integrity originally described by the US Food and Drug Administration; this acronym stands for attributable, legible, contemporaneous, original, and accurate, as well as the additional elements of complete, consistent, enduring, and available.\nConcepts: Product containing glycopyrrolate (Quaternary Ammonium Compounds)\tALCOA+ (Intellectual Product)\tAcute Intrapartum Hypoxia (Finding)\tTACE (Enzyme)\tDNA Synthesis Induction (Genetic Function)", + "output": "ALCOA+ (Intellectual Product)" + }, + { + "input": "Definition: Geographic Area described as a country in northern North America, comprised of islands in the North Atlantic Ocean, south of Newfoundland (Canada).\nConcepts: Superior carotid triangle (Head and neck structure)\tinterleukin-2 production (cytokine production)\tSt Pierre and Miquelon (Geographic Area)\tglucose-6-phosphate isomerase (Signaling Pathway Gene)\tPerformedImagingStudy.dicomStudyID (Intellectual Product)", + "output": "St Pierre and Miquelon (Geographic Area)" + }, + { + "input": "Definition: Spinal adjustments described as applying force by hand to four of a client's spinal regions that may include cervical, thoracic, lumbar, sacral and/or sacroiliac osseous and/or connective tissue to restore normal anatomical and/or physiological structure and function. Service is billed for four adjustments.\nConcepts: regulation of follicle cell microvillus length (regulation of microvillus length)\tDegree Per Millimeter (Degree Unit of Plane Angle)\tSpinal adjustment four regions each adjustment (Therapeutic or Preventive Procedure)\tRisk for corneal injury (Physical injury)\tpart of folium-tuber vermis (Body Part, Organ, or Organ Component)", + "output": "Spinal adjustment four regions each adjustment (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: nucleotide-sugar biosynthetic process described as the chemical reactions and pathways resulting in the formation of a UDP-4-deoxy-4-formamido-beta-L-arabinopyranose.\nConcepts: Psychic auras (Focal Sensory Seizure)\tUDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process (nucleotide-sugar biosynthetic process)\tMitogen-Activated protein kinase 9 (Amino Acid, Peptide, or Protein)\tSteroid Measurement (Drug measurement)\tSNDV (Virus)", + "output": "UDP-4-deoxy-4-formamido-beta-L-arabinopyranose biosynthetic process (nucleotide-sugar biosynthetic process)" + }, + { + "input": "Definition: Deformity of penis described as ventral, lateral, or ventrolateral bowing of the shaft and glans penis of more than 30 degrees.\nConcepts: Amiodarone (Antiarrythmic drugs)\tdonepezil HCl (Enzyme Inhibitors)\tmyelodysplastic syndrome (Leukocyte Disorders)\tBED, HYDRAULIC, ADJUSTABLE HOSPITAL (Beds)\tChordee of penis (Penile disorders NEC)", + "output": "Chordee of penis (Penile disorders NEC)" + }, + { + "input": "Definition: Ocular neoplasms malignancy unspecified described as tumors of the choroid; most common intraocular tumors are malignant melanomas of the choroid. These usually occur after puberty and increase in incidence with advancing age. Most malignant melanomas of the uveal tract develop from benign melanomas (nevi).\nConcepts: FOSI - I Have Swelling in Stomach Area (FOSI Questionnaire Question)\tTetraodon rubripes (Fish)\tChoroid Tumor (Disorder of choroid of eye)\tSplenomegaly (Other abdominal and pelvic symptoms)\turate metabolic process (organic acid metabolic process)", + "output": "Choroid Tumor (Disorder of choroid of eye)" + }, + { + "input": "Definition: Status described as an indication or description that the planned amount of medication was taken by the subject.\nConcepts: SMA MODIFIER 1 (Genes, Regulator)\tScleranthus annuus / scleranthus (Pharmacologic Substance)\tCDISC Questionnaire Borg CR10 Test Code Terminology (Intellectual Product)\tStudy Medication Completed (Status)\tTVA (Laboratory Procedure)", + "output": "Study Medication Completed (Status)" + }, + { + "input": "Definition: Intellectual Product described as a question associated with the HAQ-DI questionnaire.\nConcepts: abc transporters (Membrane Transport Proteins)\tCongenital Quadricuspid Aortic Valve (Congenital Heart Defects)\tHAQ-DI Questionnaire Question (Clinical or Research Assessment Question)\tH3 Protein Variant (Gene Product Sequence Variation)\tIntrastitial space (Body Space or Junction)", + "output": "HAQ-DI Questionnaire Question (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Medical Device described as apheresis units primarily designed to automate the removal of a pathologic component or toxin from the blood of a patient and/or its exchange with a replacement fluid. Typically, one or more pathologic components (e.g., antibodies, sickle cells) and/or toxins are removed and the rest of the blood is automatically reinfused. These units usually consist of a disposable pheresis set (i.e., a tubing set that connects the patient to the apheresis unit); pumps (e.g., rotary peristaltic pumps); a centrifugation chamber; bowls; filters; clamps; controls (e.g., centrifuge and pump speed, volume of solution added); alarms; and bubble detectors. Some therapeutic apheresis units use special affinity columns which contain adsorbents. These adsorbents selectively remove a pathogenic substance by chemical or antigen-antibody reactions as the plasma is pumped through the column rather than centrifugation.\nConcepts: RNA, 7SK, Nuclear (Biologically Active Substance)\tSmoothened Homolog (Drosophila) Gene Mutation (Gene Mutant)\tArm heaviness (Clinical or Research Assessment Question)\tregulation of stem cell renewal (regulation of cell division)\tTherapeutic Apheresis Units (Apheresis Units)", + "output": "Therapeutic Apheresis Units (Apheresis Units)" + }, + { + "input": "Definition: Nitrogen Mustard Antineoplastic Compounds described as a form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.\nConcepts: Liberian race (African race)\tUDP-L-rhamnose:quercetin 3-O-rhamnosyltransferase activity (Molecular Function)\tWeight loss (BODY WEIGHT AND GROWTH PROBLEMS)\tOmodysplasia 2 (Autosomal dominant hereditary disorder)\tMAFOSFAMIDE (Organic Chemical)", + "output": "MAFOSFAMIDE (Organic Chemical)" + }, + { + "input": "Definition: Childhood Astrocytoma described as a glioma affecting the optic tract and occurring in childhood.\nConcepts: optic tract glioma, childhood (Visual Pathway Glioma)\tsweet taste receptor complex (taste receptor complex)\tautologous WT1-transduced CD8-positive Tcm/Tn lymphocytes (therapeutic autologous lymphocytes)\tLPO (Organization)\tDevices, Safety (Manufactured Materials)", + "output": "optic tract glioma, childhood (Visual Pathway Glioma)" + }, + { + "input": "Definition: General treatment described as intentionally manipulating body temperature to balance heat production and loss.\nConcepts: thiamine diphosphate transporter activity (organophosphate ester transmembrane transporter activity)\tGSK 461364 (Antineoplastic Enzyme Inhibitor)\tCEMADOTIN (Vinca-Domain Binding Agent)\tGolgi to secretory granule transport (Intracellular Transport)\tImplements thermoregulation measures (Multisystem procedure)", + "output": "Implements thermoregulation measures (Multisystem procedure)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of axo-dendritic protein transport.\nConcepts: phosphatase binding (Molecular Function)\tStage IA2 Cervical Cancer FIGO 2018 (Neoplastic Process)\tregulation of axo-dendritic protein transport (regulation of intracellular protein transport)\tbradykinin catabolic process (drug catabolic process)\tQTc Correction Method Unspecified (Quantitative Concept)", + "output": "regulation of axo-dendritic protein transport (regulation of intracellular protein transport)" + }, + { + "input": "Definition: something described as a pump designed to adminster chemotherapy directly to the liver via the hepatic artery.\nConcepts: SF-36 v2.0 Standard - Question 4a (SF36 v2 0 Standard Questionnaire Question)\t2,4,4-trimethylpentanoyl-CoA dehydrogenase activity (Molecular Function)\tHAIP (Medical Device)\tSplicing (Genetic Function)\tPlatelet Activating Factor Degradation (Physiologic Function)", + "output": "HAIP (Medical Device)" + }, + { + "input": "Definition: Skull described as an abnormally increased head circumference in a growing child. Head circumference is measured with a nonelastic tape and comprises the distance from above the eyebrows and ears and around the back of the head. The measured HC is then plotted on an appropriate growth chart. []\nConcepts: Anomalous origin of coronary artery from the pulmonary artery (Anatomical Abnormality)\turidine diphospho-4-amino-2-acetamido-2,4,6-trideoxyglucose aminotransferase activity (aminotransferase activity)\thead size large (Skull)\tCDISC SDTM Relationship Type Terminology (CDISC SEND Terminology)\tosteogenic sarcoma, recurrent (Osteosarcoma)", + "output": "head size large (Skull)" + }, + { + "input": "Definition: Hamamelidaceae described as a plant genus of the family Hamamelidaceae, order Hamamelidales. It is known for the astringent (ASTRINGENTS) extract of leaves and bark used in over the counter preparations. This should not be confused with the similar named Hamelia genus (RUBIACEAE).\nConcepts: resiquimod topical gel (Pharmacologic Substance)\tEpimedium L. (Berberidoideae)\tHamamelis (Hamamelidaceae)\t4p16.3-p16.1 (Chromosome band)\tWhat was the severity of your cough at its worst (Intellectual Product)", + "output": "Hamamelis (Hamamelidaceae)" + }, + { + "input": "Definition: monocarboxylic acid biosynthetic process described as the chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid.\nConcepts: phenylpropenoic acid biosynthetic process (monocarboxylic acid biosynthetic process)\tuterus absent (Finding)\tcerebral artery (Arteries)\tEPIC1-Problem Breast Tender/Enlargement (EPIC-26 Questionnaire Question)\tPerforms as an advocate to protect the patient from incompetent, unethical, or illegal practices (Health Care Activity)", + "output": "phenylpropenoic acid biosynthetic process (monocarboxylic acid biosynthetic process)" + }, + { + "input": "Definition: Other Anatomic Concept described as a small protruding portion of tissue.\nConcepts: TGF Beta Signaling Pathway BioCarta (Signal Transduction Pathways)\tWheal Mean Diameter (Quantitative Concept)\tHAM-D6 - Clinician Version - Tiredness and Pains (Intellectual Product)\tPapilla (Body Part, Organ, or Organ Component)\tNottingham Overall Grade 2 (Intellectual Product)", + "output": "Papilla (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Hydrogen Disorders described as pathological condition that removes acid or adds base to the body fluids.\nConcepts: ALKALOSIS (Metabolic alkalosis)\tcytidine monophosphosialate hydrolase activity (Molecular Function)\tcell nucleus inheritance (nucleus organization)\tALN-TTR02 (Organic Chemical)\tCMS1A (CHAT gene)", + "output": "ALKALOSIS (Metabolic alkalosis)" + }, + { + "input": "Definition: something described as any action that results in intimidation, harm, damage, or destruction of someone or something.\nConcepts: SF3B1 D781X (SF3B1 Protein Variant)\tPlanned Number of Male Subjects (Planned Subject Number)\tviolent behavior (Level of fear: child)\tAnti-CD3 Monoclonal Antibody (Pharmacologic Substance)\tHydrolase Gene (Enzyme Gene)", + "output": "violent behavior (Level of fear: child)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a type 5 somatostatin receptor.\nConcepts: L-glutamate transmembrane transport (Cell Function)\tRabbit [dup] (Lagomorpha)\tautologous MART-1 (26-35) peptide pulsed dendritic cell vaccine (Cell)\ttype 5 somatostatin receptor binding (Molecular Function)\tmitotic chromosome segregation (mitotic cell cycle process)", + "output": "type 5 somatostatin receptor binding (Molecular Function)" + }, + { + "input": "Definition: response to organonitrogen compound described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-phenylalanine derivative stimulus.\nConcepts: Species, Threatened (Population Group)\tCOMPLEMENT C1S, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tThoracic 8 zone of esophagus (Body Location or Region)\tdetoxification of cadmium ion (Pathologic Function)\tresponse to L-phenylalanine derivative (response to organonitrogen compound)", + "output": "response to L-phenylalanine derivative (response to organonitrogen compound)" + }, + { + "input": "Definition: Cathartics described as natural or synthetic compounds usually administered orally, Antiflatulent Agents relieve or prevent flatulence, excess gas in the stomach and intestines, by adsorbing the gas, stimulating intestinal elimination of gas, or preventing gas formation. Alpha-galactosidase and activated charcoal are used against flatulence.\nConcepts: PIF1 Gene (Gene or Genome)\tNeuroaxonal dystrophy (Peripheral Nervous System)\tMedicinal product acting as antiflatulent agent (digestive aid mixtures)\tciliary vesicle (Cell Component)\tergosteryl 3-beta-D-glucoside catabolism (ergosteryl 3-beta-D-glucoside metabolic process)", + "output": "Medicinal product acting as antiflatulent agent (digestive aid mixtures)" + }, + { + "input": "Definition: something described as the series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception.\nConcepts: SPECULUM, NON-ILLUMINATED (Medical Device)\tregulation of establishment of mitochondrion localisation involved in mitochondrial fission (regulation of mitochondrial fission)\tBRAF NM 004333.4:c.1396G>C (Cell or Molecular Dysfunction)\tsensory transduction of chemical stimulus during sensory perception (detection of chemical stimulus)\tBilane (Intermediary product of metabolism)", + "output": "sensory transduction of chemical stimulus during sensory perception (detection of chemical stimulus)" + }, + { + "input": "Definition: Nail abnormality described as nail that appears thick when viewed on end.\nConcepts: Cytokine Receptor Crl2 Gene Mutation (Gene Mutant)\tONYCHOGRYPHOSIS (Disease or Syndrome)\tLocalised severe acute periodontitis (Disease or Syndrome)\tColiphage phiX174 (Sinsheimervirus)\t18q12-q21 (Chromosome band)", + "output": "ONYCHOGRYPHOSIS (Disease or Syndrome)" + }, + { + "input": "Definition: something described as a constant of proportionality that exists between electric displacement and electric field intensity in a vacuum. This constant is equal to approximately 8.854187817x10E-12 farad per meter (F/m).\nConcepts: Germicides, Liquid, Ortho-phthalaldehyde (Medical Device)\tMalagasy Republic (Country)\tRelating with subordinates (Formal relationships)\tElectric Constant (Quantitative Concept)\t5'-dephosphopolynucleotide kinase activity (phosphotransferase activity, alcohol group as acceptor)", + "output": "Electric Constant (Quantitative Concept)" + }, + { + "input": "Definition: Autosomal recessive hereditary disorder described as an autosomal recessive inherited type of glycogen storage disease. It is characterized by a deficiency of the enzyme glucose-6-phosphatase, resulting in the inability of the liver to produce free glucose causing severe hypoglycemia. There is abnormal accumulation of glycogen in the liver and kidneys.\nConcepts: Glycogen storage disease type Ia (Congenital digestive system anomalies)\tPAPS:psychosine sulphotransferase activity (Molecular Function)\tNPI - Aberrant Motor Behavior Distress (Intellectual Product)\tFixed Loop Instruments, Ear Canal (Medical Device)\tcellular nitrogen compound metabolic process (Organism Function)", + "output": "Glycogen storage disease type Ia (Congenital digestive system anomalies)" + }, + { + "input": "Definition: something described as technique for the isolation of genomic or cDNAs on the basis of their biological activity in vivo; DNA expressing activity of interest transfected into cells, DNA then isolated by selection and cloning; requires no prior knowledge of DNA sequence or location.\nConcepts: I've been pretty successful in life (Intellectual Product)\tfatty-acyl-[acp] elongase/decarboxylase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tR Wave Abnormality by ECG Finding (Laboratory or Test Result)\texpression cloning (Molecular Biology Research Technique)\tENDOCERVICAL (Intracavitary Route of Drug Administration)", + "output": "expression cloning (Molecular Biology Research Technique)" + }, + { + "input": "Definition: Finding described as problem associated with suction equipment, which may be a manual, electrical, vacuum or pressure source operated to evacuate and remove undesired substances (air, gas, fluid, or particulates) via tubing and collection bag.\nConcepts: EN.ON (DataType)\tMetastases to pharynx (Malignant neoplasm of pharynx)\tDrug.actionModeCode (Intellectual Product)\tSuction Problem (Finding)\tInterprofessional relations (Social Behavior)", + "output": "Suction Problem (Finding)" + }, + { + "input": "Definition: something described as saw blades designed for use as the cutting component of a manually operated oscillating electric or pneumatic saw used to cut materials, objects, or anatomic structures. These devices typically consist of a detachable, toothed, circular or semicircular flat blade that is attached to a saw that includes a mechanism that oscillates at a very high speed perpendicular to the axis of the machine without full rotation. Oscillating electric/pneumatic blades are mainly used in orthopedic surgery (e.g., to cut bones) and postmortem procedures; dedicated blades are also available for saws used for cutting cast.\nConcepts: protein localization to ciliary membrane (protein localization to cilium)\tBlades, Electric/Pneumatic Saw, Oscillating (Medical Device)\tCleft upper lip, upper jaw, and palate (Congenital Abnormality)\tSCF-Met30/Pof1 ubiquitin ligase complex location (Cell Component)\tHereditary Thrombophilia Due To Protein C Deficiency (Hematology)", + "output": "Blades, Electric/Pneumatic Saw, Oscillating (Medical Device)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as any elsewhere undefined body composition test, narrative required. To help develop more comprehensive coding, please submit an ABC Terminology and Code Request Form, which is available in the back of all ABC coding publications and at www.ABCcodes.com.\nConcepts: UCTD (Disease or Syndrome)\timageTypeCode (Type Code)\tNonhematic Cells to Leukocytes Ratio Measurement (Laboratory Procedure)\tundef.bdy compn.tst narr req (Therapeutic or Preventive Procedure)\tSuberoylanilide Hydroxamic Acid (Carboxylic Acids)", + "output": "undef.bdy compn.tst narr req (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Intellectual Product described as hamilton Depression Rating Scale 24 Item - Sexual disturbances.\nConcepts: HAMD314 (HAMD 24 Clinical Classification Question)\tUndefined, narrative required - christian science (Christian Science care)\tMSQL1-Did You Feel Tired (Intellectual Product)\tInterleukin-1 Gamma Gene (Gene or Genome)\t11: 125438397-125335784 (Spatial Concept)", + "output": "HAMD314 (HAMD 24 Clinical Classification Question)" + }, + { + "input": "Definition: something described as abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.\nConcepts: 1q31-q32 (Cell Component)\tthyroid hormone metabolic process (Molecular Function)\tGraefe-Usher Syndrome (Disease or Syndrome)\tosmoses (Biochemical Processes)\tTHER HYPERTHERMIA (Physical therapy)", + "output": "THER HYPERTHERMIA (Physical therapy)" + }, + { + "input": "Definition: Research Activity described as experiment in which assignment of patients to the intervention groups is at the convenience of the investigator or according to a pre-set plan that does not conform to the definition of RANDOM.\nConcepts: thermocoagulation (Electrolysis)\tNONRANDOMIZED CONTROL TRIALS (Research Activity)\tpositive regulation of Wnt-activated signaling pathway by BMP signaling pathway (Cell Function)\tHypopharyngeal Cancer TNM Finding v7 (Pharyngeal Cancer TNM Finding v7)\tHypopharyngeal Carcinoma cN3b TNM Finding v8 (Finding)", + "output": "NONRANDOMIZED CONTROL TRIALS (Research Activity)" + }, + { + "input": "Definition: mitochondrial transmembrane transport described as the process in which 3'-phospho-5'-adenylyl sulfate is transported across a mitochondrial membrane, into or out of the mitochondrion.\nConcepts: Product containing fluoromisonidazole (Fluorine Radioisotopes)\tETV6-RUNX1 Fusion Protein Expression (Cell or Molecular Dysfunction)\tacrylate:acyl-coA CoA transferase activity (transferase activity, transferring acyl groups other than amino-acyl groups)\tUNASSIGNED (Drug Administration Routes)\tmitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport (Cell Function)", + "output": "mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport (Cell Function)" + }, + { + "input": "Definition: intermediate gray column described as the portion of the intermediate gray column not occupied by the central cervical nucleus or the thoracic column in the rat ( Swanson-2004 ).\nConcepts: intermediate gray of the spinal cord proper (Body Part, Organ, or Organ Component)\tPituitary spindle cell oncocytoma (Neoplastic Process)\tPUL02-Flexion Above Shoulder Height 500g (Intellectual Product)\tcarbon utilization (Biological Processes)\tPLCD3 wt Allele (PLCD3 gene)", + "output": "intermediate gray of the spinal cord proper (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salt stimulus.\nConcepts: AURC % Extrapolation Pred (Quantitative Concept)\tPHENO (P [Preparations])\tresponse to salt (Cell Function)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, TGFBR1 (Medical Device)\tsource (Finding)", + "output": "response to salt (Cell Function)" + }, + { + "input": "Definition: something described as tender erythema covering 10-30% BSA\nConcepts: Unusual protozoan infection (Unusual infection)\tGrade 2 Photosensitivity (Photosensitivity, CTCAE)\tSmall male external genitalia (Male external genitalia structure)\tNursing, Private Duty (Discipline of Nursing)\tarteriovenous haemangioma (Distention of blood vessel)", + "output": "Grade 2 Photosensitivity (Photosensitivity, CTCAE)" + }, + { + "input": "Definition: Climatic Processes described as sudden onset water phenomena with different speed of occurrence. These include flash floods, seasonal river floods, and coastal floods, associated with CYCLONIC STORMS; TIDALWAVES; and storm surges.\nConcepts: Bilirubin Crystal Measurement (Crystal Growth Measurement)\tGAIA Preterm Labor Levels of Diagnostic Certainty (GAIA Pathways to Preterm Birth Level of Diagnostic Certainty)\timmune tolerance/unresponsiveness (Immune status)\tflood (Non-occupational and unspecified environmental problems)\tanchored component of neuronal dense core vesicle membrane (anchored component of membrane)", + "output": "flood (Non-occupational and unspecified environmental problems)" + }, + { + "input": "Definition: Neoplastic Process described as an epithelioid hemangioendothelioma that has spread from its original site of growth to nearby tissues or lymph nodes.\nConcepts: 2-phenyl-1,3-propanediol dicarbamate (Organic Chemical)\tVastus intermedius (Skeletal muscle structure of hip and/or thigh)\tcell surface receptor signaling pathway involved in heart development (Molecular Function)\tLocally Advanced Epithelioid Hemangioendothelioma (Metastatic Epithelioid Hemangioendothelioma)\tmesodermal cell fate determination (cell fate determination)", + "output": "Locally Advanced Epithelioid Hemangioendothelioma (Metastatic Epithelioid Hemangioendothelioma)" + }, + { + "input": "Definition: something described as <1000/mm3; <1.0 x 10e9/L\nConcepts: Grade 4 White Blood Cell Decreased, CTCAE (White Blood Cell Decreased, CTCAE)\tMIR510 wt Allele (Gene or Genome)\tKallikrein Kinin System (Metabolic Networks and Pathways)\tIVD Test Reagent/Kits, Home Assay, Urine, Nitrate (Medical Device)\tinterleukin-1 binding activity (cytokine binding)", + "output": "Grade 4 White Blood Cell Decreased, CTCAE (White Blood Cell Decreased, CTCAE)" + }, + { + "input": "Definition: Finding described as a disorder characterized by laboratory test results that indicate an increased number of white blood cells in the blood.\nConcepts: 2-methylbutanoyl-CoA:acceptor oxidoreductase activity (acyl-CoA dehydrogenase activity)\tADCS-ADL Severe Dementia - Description of Usual Performance of Finding Personal Belonging at Home (Intellectual Product)\tHPV L1 VLP vaccine V504 (Human Papilloma Virus Vaccine)\ttype 2 neuromedin U receptor binding (Molecular Function)\tLeukocytosis, CTCAE (Finding)", + "output": "Leukocytosis, CTCAE (Finding)" + }, + { + "input": "Definition: something described as microscopes and accessories are optical instruments used to enlarge images of specimens, preparations, and cultures for medical purposes. Variations of microscopes and accessories (through a change in the light source) used for medical purposes include the following: (1) Phase contrast microscopes, which permit visualization of unstained preparations by altering the phase relationship of light that passes around the object and through the object. (2) Fluorescense microscopes, which permit examination of specimens stained with fluorochromes that fluoresce under ultraviolet light. (3) Inverted stage microscopes, which permit examination of tissue cultures or other biological specimens contained in bottles or tubes with the light source mounted above the specimen.\nConcepts: Grade 4 Serum Amylase Increased, CTCAE (Serum Amylase Increased, CTCAE)\tgastrointestinal function (Chemical procedure)\tThymic Tumor pT2 TNM Finding v8 (Thymic Tumor Pathologic Primary Tumor TNM Finding v8)\tMICROSCOPE, INVERTED STAGE, TISSUE CULTURE (Medical Device)\tBacterial DNA (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "MICROSCOPE, INVERTED STAGE, TISSUE CULTURE (Medical Device)" + }, + { + "input": "Definition: something described as molecular assay reagents intended to identify mutations in the cytochrome P450 family 11 subfamily B member 1 (CYP11B1) gene, located at chromosome 8q21, which encodes the mitochondrial protein cytochrome P450 11B1. Genetic variants at this locus have been associated with familial hyperaldosteronism type 1 and deficiency of steroid 11-beta-monooxygenase.\nConcepts: Product containing quazepam (Hypnotics)\tLiliales Perleb, 1826 (Plant)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CYP11B1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tregulation of rate of heart contraction (regulation of blood circulation)\tPeculiar (General Qualifier)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, CYP11B1 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)" + }, + { + "input": "Definition: Hematologic Tests described as an average of the measurements of the magnitude of the platelet aggregation in a biological specimen.\nConcepts: Plasmacytoma-like PTLD (Plasma Cell Post-Transplant Lymphoproliferative Disorder)\tRelevantRegulation (Intellectual Product)\tPlatelet Aggregometry Mean Amplitude (Laboratory Procedure)\tGAIA Stillbirth Level of Diagnostic Certainty (GAIA Neonatal Case Definitions)\tTransurethral biopsy prostate (Operations by approach)", + "output": "Platelet Aggregometry Mean Amplitude (Laboratory Procedure)" + }, + { + "input": "Definition: something described as heterocyclic compounds in which an oxygen is attached to a cyclic nitrogen.\nConcepts: quinone metabolism (Metabolic Detoxication, Drug)\timaging techniques (Natural Science Disciplines)\tMORT1 protein, human (Adaptor Proteins, Signal Transducing)\tCyclic N Oxides (Heterocyclic Oxides)\tAEE788 (Protein-tyrosine kinase inhibitor)", + "output": "Cyclic N Oxides (Heterocyclic Oxides)" + }, + { + "input": "Definition: something described as branch of developmental psychology devoted to the study and treatment of adolescents. Use a more specific term if possible.\nConcepts: Spinal cord sulcus (Body Space or Junction)\tadolescent psychology (Psychology)\tPhenotypic Multiple Antigen Bead-based Multiplex Assay (Laboratory Procedure)\tMMSE-2 Standard Version - Point to the Circle (Intellectual Product)\tauxin:hydrogen symporter activity (auxin transmembrane transporter activity)", + "output": "adolescent psychology (Psychology)" + }, + { + "input": "Definition: Neuroblastoma described as a neuroblastoma that occurs during childhood.\nConcepts: n-dodecanoic acid metabolic process (antibiotic metabolic process)\tGrade 2 Chylothorax, CTCAE (Chylothorax, CTCAE)\tChildhood Neuroblastoma (Neuroblastoma)\tChemokine receptor antagonist-containing product (Substance with receptor antagonist mechanism of action)\tAbnormality of muscle size (Finding)", + "output": "Childhood Neuroblastoma (Neuroblastoma)" + }, + { + "input": "Definition: positive regulation of DNA-templated transcription, initiation described as any process that increases the rate, frequency or extent of a process involved in starting transcription from an RNA polymerase II promoter.\nConcepts: Inferior rectus muscle of eye (Skeletal muscle structure of head)\tHyperaldosteronemia (Finding)\tSkull Postmortem Chisels (Chisels, Postmortem)\tHAQ01-Aid: Devices Used for Dressing (HAQ-DI Questionnaire Question)\tpositive regulation of transcription initiation from RNA polymerase II promoter (positive regulation of DNA-templated transcription, initiation)", + "output": "positive regulation of transcription initiation from RNA polymerase II promoter (positive regulation of DNA-templated transcription, initiation)" + }, + { + "input": "Definition: protein phosphatase activity described as catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate.\nConcepts: Expiratory Muscle Strength Training (Therapeutic or Preventive Procedure)\tfecal DNA test (DNA analysis)\tprotein tyrosine/serine/threonine phosphatase activity (Molecular Function)\tNiraparib Regimen (Regimen Used to Treat Malignant Peritoneal Neoplasm)\tCHROMOSOME 15q11-q13 DUPLICATION SYNDROME (Disease or Syndrome)", + "output": "protein tyrosine/serine/threonine phosphatase activity (Molecular Function)" + }, + { + "input": "Definition: something described as simultaneous administration of multiple medications to treat the same illness.\nConcepts: Refluxing Non-Obstructed Megaureter (Finding)\tAr (Non-SI unit of area)\tSecond Cancers (Malignant Neoplasms)\tFatty Acid 16:3 n-4 (Organic Chemical)\tPolymedication (Pharmacotherapy)", + "output": "Polymedication (Pharmacotherapy)" + }, + { + "input": "Definition: Neoplastic Process described as a leiomyosarcoma that has spread to other anatomical sites.\nConcepts: How much of the time did your caregiving responsibilities make it difficult for you to think clearly when working (Clinical or Research Assessment Question)\tbiological evolution (Population Process)\tMetastatic Leiomyosarcoma (leiomyosarcoma)\tt(X;17)(p11.2;q25) (Cell or Molecular Dysfunction)\tNPS01-Tell Us How Itchy Your Pain Feels (NPS Questionnaire Question)", + "output": "Metastatic Leiomyosarcoma (leiomyosarcoma)" + }, + { + "input": "Definition: something described as the determination of the amount of free triiodothyronine present in a sample.\nConcepts: Right olfactory bulb (Body Part, Organ, or Organ Component)\tPHQ-9 Questionnaire Question (Intellectual Product)\tCongenital Hyperthyroidism (Thyroid hyperfunction disorders)\tCoronal plane (Image View)\tFT3 - Free triiodothyronine level (Hormone measurement)", + "output": "FT3 - Free triiodothyronine level (Hormone measurement)" + }, + { + "input": "Definition: Congenital Disorders described as biallelic mutation carriers have a mutation (not necessarily the same mutation) in both copies of a particular gene (a paternal and a maternal mutation). The RPE65 gene provides instructions for making an enzyme that is essential for normal vision and mutations in this gene result in reduced or absent levels of RPE65 activity, blocking the visual cycle and resulting in impaired vision. Almost all patients eventually progress to complete blindness.\nConcepts: Market Withdrawal (Regulation or Law)\tTranscription Factor MafG (Amino Acid, Peptide, or Protein)\testablishment of floral organ orientation (developmental process involved in reproduction)\tBiallelic RPE65 mutation associated retinal dystrophy (Congenital Disorders)\tImmunoglobulin G1, Anti-(Human/Macaca irus/Rattus/Mus musculus Interleukin 22) (Human Monoclonal Heavy Chain), Disulfide with Human Monoclonal Lambda-Chain, Dimer (Pharmacologic Substance)", + "output": "Biallelic RPE65 mutation associated retinal dystrophy (Congenital Disorders)" + }, + { + "input": "Definition: something described as the process in which a capsid acquires another membrane envelope, subsequent to acquiring an initial membrane envelope.\nConcepts: Electrocardiography Tape Recording Processors (Data Processors, Tape Recording)\tSquamous Cell Carcinoma of Prostate (Neoplastic Process)\tK0706 (Organic Chemical)\tISBT system 003 (Blood group system OR collection)\tviral budding from inner nuclear membrane during viral capsid re-envelopment (viral process)", + "output": "viral budding from inner nuclear membrane during viral capsid re-envelopment (viral process)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as ablation of an area of the heart that the source of a dysrhythmia via the insertion of a catheter placed in the pericardial space.\nConcepts: MPAP (Pulmonary function tests)\tinhibitor of growth family, member 1-like (Apoptosis Regulation Gene)\tEpicardial Ablation (Therapeutic or Preventive Procedure)\tFemininity (Sex Behavior)\tmyopathy-lactic acidosis-sideroblastic anemia syndrome (Disease or Syndrome)", + "output": "Epicardial Ablation (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Neonatal disorder described as a self-limited inflammatory disorder of unknown etiology found in infants that causes swelling of the soft tissue, changes to bone, and irritability.\nConcepts: a brake extension for a wheelchair (Wheelchair accessory)\tDresden Prostate Carcinoma Protein 2 (Regulatory Protein)\tADRA2C protein, human (alpha-adrenergic receptor)\tCortical Congenital Hyperostoses (Hyperostosis)\t4-O-(2,6-Diamino-2,6-dideoxy-alpha-D-glucopyranosyl)-2-deoxy-D-streptamine (neomycin)", + "output": "Cortical Congenital Hyperostoses (Hyperostosis)" + }, + { + "input": "Definition: Head described as the area above or over the sella turcica.\nConcepts: HER-2 (Immunologic Factor)\tFYN gene (Genes, src)\tReading (Data)\tAURC Infinity Pred (Quantitative Concept)\tSuprasellar region (Structure of organ cavity subdivision)", + "output": "Suprasellar region (Structure of organ cavity subdivision)" + }, + { + "input": "Definition: Pesticides described as a synthetic organic thiophosphate compound and organophosphate acetylcholinesterase inhibitor and neurotoxin that is used as a pesticide. It is characterized as a volatile colorless or off-white crystalline solid with a pungent odor, and exposure occurs by inhalation, ingestion, or contact.\nConcepts: Eyelid Carcinoma pT4a TNM Finding v8 (Eyelid Carcinoma pT4 TNM Finding v8)\tmethamidophos (Acetylcholinesterase Inhibitors)\tglutamate synthase complex location (Cell Component)\tLugano Lymphoma Response Classification Complete Remission by CT (Lugano Lymphoma Response Classification)\tFamilial type 5 hyperlipoproteinemia (Hypertriglyceridemia)", + "output": "methamidophos (Acetylcholinesterase Inhibitors)" + }, + { + "input": "Definition: Abnormal carotid artery morphology described as a dilatation (balooning or bulging out of the vessel wall) of a carotid artery.\nConcepts: Syndromes, Chromosome 5p- (Autosomal Chromosome Disorders)\tCarotid artery dilatation (Anatomical Abnormality)\tLymphatic Metastasis (Neoplasm Metastasis)\tAnaerobic Coccus (Bacterium)\tNasopharyngeal Cancer pT3 TNM Finding v7 (Nasopharyngeal Cancer Pathologic Primary Tumor TNM Finding v7)", + "output": "Carotid artery dilatation (Anatomical Abnormality)" + }, + { + "input": "Definition: Positive Laboratory Test Result described as an indication that antibodies that recognize the CMV 65 kDa phosphoprotein have been detected in a sample.\nConcepts: 5-fluorocytosine deaminase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)\thippocampal formation development (Organ or Tissue Function)\tresponse to beta-amyloids (Cell Function)\tPhosphoprotein UL83 Antibody Positive (Positive Laboratory Test Result)\tRefractory Cutaneous T-Cell Non-Hodgkin Lymphoma (Neoplastic Process)", + "output": "Phosphoprotein UL83 Antibody Positive (Positive Laboratory Test Result)" + }, + { + "input": "Definition: something described as plethysmographs designed for non-invasive measuring and recording data and graphics (i.e., a plethysmogram) of the volume and variations in volume of the lower limbs due to the presence and flow of blood in the vascular system based on the measurement of the volume waveform and amplitude. This technique is also known as segmental plethysmography, pulse volume recording (PVR) plethysmography, and pneumo plethysmography. These devices typically consist of a unit that measures, records, and displays the results (usually in graphic format) and compression cuffs, sensors (e.g., pressure, volume), transducers, and signal amplifiers. The sensors are applied to several points (e.g., thigh, calf, ankle) to measure pressure changes in the bladder of the cuff wrapped around the limb. These changes reflect changes in the cuff volume, which is a direct reflection of changes within the limb volume. Lower limb segmental plethysmographs are used to assess peripheral circulation and to assist in diagnosing diseases/disorders related to venous blood flow (e.g., deep venous thrombosis).\nConcepts: Startle Reaction (Examination of reflexes)\tKaraya (Plant)\tmitotic spindle checkpoint (spindle checkpoint activity)\tPhleborheographs (Plethysmographs, Lower Limb)\tTFIIIC63 (TFIIIC Subunit Gene)", + "output": "Phleborheographs (Plethysmographs, Lower Limb)" + }, + { + "input": "Definition: something described as an adverse event in a newborn characterized by hemorrhagic secretion in an endotracheal (ET) tube; with relevant increase in partial pressure of carbon dioxide (pCO2) or decrease in oxygenation; requiring major change in ventilatory support or transfusion.\nConcepts: acyl-carrier-protein acetyltransferase activity (S-acetyltransferase activity)\tGrade 3 Neonatal Pulmonary Hemorrhage, AE (Neonatal Pulmonary Hemorrhage, Adverse Event)\tHAQ01-Get In and Out of Bed (HAQ-DI Questionnaire Question)\tGastrointestinal nonspecific dysfunction (Classification)\tepithelial cell differentiation involved in embryonic placenta development (cell differentiation involved in embryonic placenta development)", + "output": "Grade 3 Neonatal Pulmonary Hemorrhage, AE (Neonatal Pulmonary Hemorrhage, Adverse Event)" + }, + { + "input": "Definition: something described as life-threatening consequences (e.g. shock); requiring urgent major care changes.\nConcepts: ORTHOSTATIC HYPOTENSION (Cardiovascular Diseases)\tFemara/Lupron (Regimen Used to Treat Breast Carcinoma)\tCOMM101 (Intellectual Product)\tGrade 4 Neonatal Bradyarrhythmia (Neonatal Bradyarrhythmia, Adverse Event)\tZinc Finger Protein SALL4 (Amino Acid, Peptide, or Protein)", + "output": "Grade 4 Neonatal Bradyarrhythmia (Neonatal Bradyarrhythmia, Adverse Event)" + }, + { + "input": "Definition: Research Activity described as method of data collection and a qualitative research tool in which a small group of individuals are brought together and allowed to interact in a discussion of their opinions about topics, issues, or questions.\nConcepts: Chudley Rozdilsky syndrome (Intellectual Disability)\tAmendment Change Summary Version Document (Document type)\tglycopeptide (Amino Acid, Peptide, or Protein)\tNuclear Pore Complex (Cell protein complex)\tFocus Groups (Interview)", + "output": "Focus Groups (Interview)" + }, + { + "input": "Definition: something described as the name of the chemical challenge agent used in the study.\nConcepts: AUT (Country)\tMYXOSARCOMA, MALIGNANT (Sarcoma)\tChemical Challenge Agent Name (Intellectual Product)\tsucrose transport (Cell Function)\tBrucella melitensis abortus (Brucella species)", + "output": "Chemical Challenge Agent Name (Intellectual Product)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation.\nConcepts: induction of conjugation upon nitrogen starvation (cellular response to nitrogen starvation)\tMRS (nuclear spectroscopy)\tMODELS CHEM (Study models)\tVestibular fistula (Rectal Fistula)\tground meristem histogenesis (Organism Function)", + "output": "induction of conjugation upon nitrogen starvation (cellular response to nitrogen starvation)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum described as serology reagents intended to detect antibodies to Histoplasma capsulatum, a yeast-like species of imperfect fungi of the family Moniliaceae. Histoplasma capsulatum infection (histoplasmosis) is frequently asymptomatic, but can cause an influenza-like illness or pneumonia. These fungi can affect the lungs, meninges, heart, and other organs in immunocompromised patients.\nConcepts: ANTISERA, NEUTRALIZATION, COXSACKIEVIRUS A 1-24, B 1-6 (Immunologic Factor)\tRemoval of necrotic bone fragment (Other excision procedures on bone of other musculoskeletal sites)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum, Antibody (IVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum)\tEffusion;pleural (Edema)\tDisorder by Site (Disease)", + "output": "IVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum, Antibody (IVD Test Reagent/Kits, Serology, Fungi/Yeast, Histoplasma capsulatum)" + }, + { + "input": "Definition: neutral lipid catabolic process described as the chemical reactions and pathways resulting in the breakdown of acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids.\nConcepts: Grade 4 Vascular Disorders - Other, Specify, CTCAE (Finding)\tacylglycerol breakdown (acylglycerol metabolic process)\tK14R (Cell or Molecular Dysfunction)\tinternuclear area of the periventricular region (Body Location or Region)\tsynaptic membrane adhesion to extracellular matrix (Cell-Matrix Junction)", + "output": "acylglycerol breakdown (acylglycerol metabolic process)" + }, + { + "input": "Definition: T-Cell Leukemia Viruses, Human described as a human deltaretrovirus related to HTLV-1. Although human T-lymphotropic virus-2 (HTVL-2) has been isolated in association with specific diseases it has not been shown to have a causal relationship with any disease.\nConcepts: hypoglossal nucleus (Medulla oblongata part)\tHuman T-lymphotropic virus, type II (T-Cell Leukemia Viruses, Human)\tpeptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine (peptidyl-isoleucine modification)\tthymic lymphocyte migration (Cell Function)\t15 trisomy (Autosomal Chromosome Disorders)", + "output": "Human T-lymphotropic virus, type II (T-Cell Leukemia Viruses, Human)" + }, + { + "input": "Definition: something described as the change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.\nConcepts: GCS NINDS Version - Confounder: GCS Accurate (GCS NINDS Version Clinical Classification Question)\tskeletal muscle satellite cell activation (cell activation)\tdiadenosine polyphosphate catabolic process (Molecular Function)\tsmoking (Tobacco use)\t2-methyl-3-phytyl-1,4-naphthoquinone:oxidized-dithiothreitol oxidoreductase activity (Molecular Function)", + "output": "skeletal muscle satellite cell activation (cell activation)" + }, + { + "input": "Definition: Other Finding described as muscular dystrophy secondary to a mitochondrial disorder.\nConcepts: GAGED3 Gene (Gene or Genome)\tMitochondrial (Disease or Syndrome)\tHLA Class II Antibody Measurement (Immunologic Tests)\tImmune Cell Destruction Induction (Cell Function)\tFIQR - Balance Problems (FIQR Questionnaire Question)", + "output": "Mitochondrial (Disease or Syndrome)" + }, + { + "input": "Definition: negative regulation of sprouting of injured axon described as any process that stops, prevents or reduces the frequency, rate or extent of formation of growth cone in injured axon.\nConcepts: C11orf95 wt Allele (C11orf95 gene)\tRadiation Therapist (Clinical oncologist)\tAUGMENTATION OF ORAL DIURETIC THERAPY (Therapeutic or Preventive Procedure)\tnegative regulation of formation of growth cone in injured axon (Cell Function)\tThelazioidea (Eukaryote)", + "output": "negative regulation of formation of growth cone in injured axon (Cell Function)" + }, + { + "input": "Definition: Enzyme described as eosinophil lysophospholipase (142 aa, ~16 kDa) is encoded by the human CLC gene. This protein is involved in phospholipid metabolism.\nConcepts: CEDECEA DAVISAE (Cedecea)\tADCRLT02 (ADAS-Cog CDISC Version Questionnaire Question)\tBacteroides intestinalis (Bacterium)\tAcral keratosis (Skin, Human)\tLysolecithin Acylhydrolase (Phospholipase)", + "output": "Lysolecithin Acylhydrolase (Phospholipase)" + }, + { + "input": "Definition: Study Characteristics described as comparison of outcomes, results, responses, etc for different techniques, therapeutic approaches or other inputs.\nConcepts: Comparative Studies (Intellectual Product)\tnr-axSpA - non-radiographic axial spondylitis (Disease or Syndrome)\tSoftware, Physiologic Analysis, Neuromuscular Function, Body Motion (Software, Physiologic Analysis)\tHemodialysis Catheter-Associated Bacteremia (Infection of hemodialysis catheter)\tinotropes milrinone lactate (milrinone)", + "output": "Comparative Studies (Intellectual Product)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of tetrapyrrole biosynthetic process.\nConcepts: C-SSRS Lifetime/Recent Version - Description of Preparatory Acts or Behaviors Toward Suicide Attempt (C-SSRS Lifetime/Recent Version Questionnaire Question)\tType A Cyclin (Amino Acid, Peptide, or Protein)\tChill (Body Temperature States and Skin Functions)\tASEX-Male Version - Sex Drive (ASEX-Male Version Questionnaire Question)\tregulation of tetrapyrrole biosynthetic process (regulation of cellular biosynthetic process)", + "output": "regulation of tetrapyrrole biosynthetic process (regulation of cellular biosynthetic process)" + }, + { + "input": "Definition: Clinical or Research Assessment Question described as a question about an individual's agreement that they would not have confidence in a medical test or treatment if experts had conflicting opinions about it.\nConcepts: Left Lung (Structure of half of thoracic cavity lateral to midsagittal plane)\tWould Not Have Confidence in a Medical Test or Treatment if Experts Had Conflicting Opinions (Clinical or Research Assessment Question)\t17-Beta-HSD 3 (Amino Acid, Peptide, or Protein)\tStage II Vulvar Cancer (Vulvar Cancer by AJCC v6 Stage)\tPectus excavatum inferiorly (Pectus excavatum)", + "output": "Would Not Have Confidence in a Medical Test or Treatment if Experts Had Conflicting Opinions (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Intellectual Product described as a worldwide unique identifier allocated to a medicinal product that is supplementary to any existing identifier approved by a regulatory authority in the country of authorization.\nConcepts: medicinal product identifier (Product Identifier)\tDisease Outcome (CDISC SDTM Terminology)\tneuroendocrinology (Neuroscience discipline)\tBronchus Endoscopic Dilators (Medical Device)\tfragilitans; osteitis (Hereditary disorder of musculoskeletal system)", + "output": "medicinal product identifier (Product Identifier)" + }, + { + "input": "Definition: something described as workers who perform a variety of customer service, food preparation, and cleaning duties in restaurants, cafeterias, and other eating and drinking establishments.\nConcepts: Hallucination, Gustatory (Hallucinations)\tnegative regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator (regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)\tPars cardiaca (Zone of stomach)\tIntegumentary System Signs and Symptoms (Sign or Symptom)\tFood and Beverage Serving Workers (Professional or Occupational Group)", + "output": "Food and Beverage Serving Workers (Professional or Occupational Group)" + }, + { + "input": "Definition: something described as a breast fibroadenoma characterized by a very large size. This term has also been used as a synonym for juvenile fibroadenoma by some authors. The latter is characterized by epithelial hyperplasia and an increased stromal cellularity.\nConcepts: Native Mussel (Eukaryote)\tMurine TYRP2 Plasmid DNA Vaccine (Pharmacologic Substance)\tBlood cell (Entire cell)\tCardiolipin IgA Antibody Measurement (Immunologic Tests)\tGiant Fibroadenoma of the Breast (Fibroadenosis of breast)", + "output": "Giant Fibroadenoma of the Breast (Fibroadenosis of breast)" + }, + { + "input": "Definition: something described as leukocyte immunoglobulin-like receptor subfamily B member 2 (598 aa, ~65 kDa) is encoded by the human LILRB2 gene. This protein is involved in the regulation of class I MHC antigen responses.\nConcepts: Maxillary Sinus Cancer pT4b TNM Finding v6 (Finding)\tImmunoglobulin-Like Transcript 4 (receptor)\tGlycinamide ribonucleotide formyltransferase (Transferase Gene)\t4-hydroxyproline transport (amino acid transport)\tBlastocyst Transfer (Therapeutic or Preventive Procedure)", + "output": "Immunoglobulin-Like Transcript 4 (receptor)" + }, + { + "input": "Definition: Intellectual Product described as a question about how often a person thought about increasing their volunteer work to help others in the community.\nConcepts: Garcinia L., 1753 (Clusiaceae)\tHow often did you experience discomfort or pain following vaginal penetration (Clinical or Research Assessment Question)\tCardiobacterium, NOS (Fermentative Gram-negative bacillus)\tacne; vulgaris (Disease or Syndrome)\tIncrease Volunteer Work to Help Others in Community (Clinical or Research Assessment Question)", + "output": "Increase Volunteer Work to Help Others in Community (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: Antibiotics described as a 1-beta-methyl carbapenem and broad-spectrum beta-lactam antibiotic with bactericidal property. Ertapenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, in particular PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and subsequent lysis of the cell wall leading to cell death of Gram-positive and Gram-negative aerobic and anaerobic pathogens. This agent is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, cephalosporinases and extended-spectrum beta-lactamases.\nConcepts: Prostate Cancer Pathologic Distant Metastasis TNM Finding v7 (Finding)\tInterleukin 1 Receptor-Like 1 (Protein or Enzyme Type Measurement)\tErtapenem-containing product (Monobactams)\tEGFR T790M inhibitor PF-06747775 (Organic Chemical)\temericellamide A metabolic process (emericellamide metabolic process)", + "output": "Ertapenem-containing product (Monobactams)" + }, + { + "input": "Definition: Qualitative Concept described as a benefit, consideration, or positive motivational influence, financial or otherwise, given to induce a specific action.\nConcepts: Basilic vein (Upper arm)\tFormaldeh\u00eddo (Aldehydes)\tinsulary cortex (Insula and opercula)\tIncentives (Motivation)\tsnoRNP assembly (ribonucleoprotein complex assembly)", + "output": "Incentives (Motivation)" + }, + { + "input": "Definition: Component of the National Institutes of Health described as the Office for Protection from Research Risks (OPRR) is organizationally located in the Office of the Director, NIH. OPRR is charged with interpreting and overseeing implementation of the regulations regarding the Protection of Human Subjects codified at Title 45, Part 46, of the Code of Federal Regulations. Also, OPRR is responsible for providing guidance on ethical issues in biomedical and behavioral research.\nConcepts: MLL/AF15q14 Fusion Protein (Biologically Active Substance)\tRPN-I (glycosyltransferase)\tOPRR (Health Care Related Organization)\tregulation of cellular component biogenesis (regulation of cellular process)\tBilateral Sacral Flexion (Sacral flexion)", + "output": "OPRR (Health Care Related Organization)" + }, + { + "input": "Definition: Iron Metabolism Disorders described as an idiopathic form of neonatal hemochromatosis, characterized by liver failure and iron accumulation in the tissues.\nConcepts: Allopathic & Osteopathic Physicians; Psychiatry & Neurology, Vascular Neurology (Professional or Occupational Group)\tCMD193 (Immunotoxins)\tNeonatal hemochromatosis (Neonatal hepatobiliary disorders)\tGlycoprotein (Chemo Immunostimulant Adjuvant)\tTreatment, Tocolytic (Medical procedure AND/OR service related to reproduction)", + "output": "Neonatal hemochromatosis (Neonatal hepatobiliary disorders)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as PR domain zinc finger protein 4 (801 aa, ~88 kDa) is encoded by the human PRDM4 gene. This protein plays a role in transcriptional regulation, cell cycle progression, cell proliferation and signal transduction.\nConcepts: Lissencephaly co-occurrent with congenital cerebellar hypoplasia type E (Hereditary Diseases)\tAIMS01-Tongue (AIMS Clinical Classification Question)\tPRDM4 (TRANSCRIPTION FACTOR)\tSpleen Trabecular Vein (Anatomical Structure)\tDiscrimination, Speech (Mental Process)", + "output": "PRDM4 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as treatment that is given after initial therapy to kill any remaining cancer cells.\nConcepts: 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride (D [Preparations])\tConsolidation Therapy (Chemotherapy)\tSUBCUTANEOUS (Parenteral Route of Drug Administration)\tpositive regulation of muscle cell apoptosis (Positive Regulation of Apoptosis)\tElevated urinary norepinephrine (Elevated urinary catecholamines)", + "output": "Consolidation Therapy (Chemotherapy)" + }, + { + "input": "Definition: Population Group described as individuals whose day-to-day life is influenced by people in positions of authority in work, school or other settings, such as students, workers and members of a religious group.\nConcepts: People in subordinate positions (CHAPTER 3 SUPPORT AND RELATIONSHIPS)\tA1 adenosine receptor binding (adenosine receptor binding)\tUnresectable Renal Cell Carcinoma (Unresectable Carcinoma)\tPROSTHESIS, HIP, FEMORAL, RESURFACING (Medical Device)\tsampled (Observation - action)", + "output": "People in subordinate positions (CHAPTER 3 SUPPORT AND RELATIONSHIPS)" + }, + { + "input": "Definition: Parasympathomimetic Agents described as a natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent, pilocarpine predominantly binds to muscarinic receptors, thereby inducing exocrine gland secretion and stimulating smooth muscle in the bronchi, urinary tract, biliary tract, and intestinal tract. When applied topically to eyes, this agent stimulates the sphincter pupillae to contract, resulting in miosis; stimulates the ciliary muscle to contract, resulting in spasm of accommodation; and may cause a transitory rise in intraocular pressure followed by a more persistent fall due to opening of the trabecular meshwork and an increase in the outflow of aqueous humor.\nConcepts: Cross-Over Studies (Epidemiologic Research Design)\tdownregulation of protein kinase B signaling cascade (Molecular Function)\tdIDP phosphorylation (nucleoside diphosphate phosphorylation)\tS100A2 wt Allele (Gene or Genome)\tPilocarpine-containing product (Parasympathomimetic Agents)", + "output": "Pilocarpine-containing product (Parasympathomimetic Agents)" + }, + { + "input": "Definition: EEG with generalized epileptiform discharges described as the burst suppression pattern in electroencephalography refers to a characteristic periodic pattern of low voltage (<10 microvolts) suppressed background and a relatively shorter pattern of higher amplitude slow, sharp, and spiking complexes.\nConcepts: Coccolithophorid (Haptista)\tEEG with burst suppression (Finding)\tDNA Methylase, Cytosine-Specific (Amino Acid, Peptide, or Protein)\tAnalyzers, Physiologic, Extracellular Limb Fluid, Electrical Impedance (Analyzers, Physiologic)\tSertraline (Measurement of substance)", + "output": "EEG with burst suppression (Finding)" + }, + { + "input": "Definition: C-SSRS Already Enrolled Subjects Questionnaire Question described as columbia-Suicide Severity Rating Scale Already Enrolled Subjects - Have you been thinking about how you might do this? (Prior to Study Entry).\nConcepts: CSS0503A (Intellectual Product)\tC-45 EOSINOPHILIAS (Disorder characterized by eosinophilia)\tAllogeneic EBV-Specific CTL (Allogeneic Lymphocyte)\tPQL18-Feel Tired (PedsQL Neuromuscular Module Acute Version 3.0 Parent of Toddler Questionnaire Question)\tenzyme-directed rRNA 2'-O-methylation (rRNA 2'-O-methylation)", + "output": "CSS0503A (Intellectual Product)" + }, + { + "input": "Definition: Organism Function described as the process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions.\nConcepts: Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-, (2S-(1(R*(R*)), 2alpha, 3abeta, 7abeta))- (Isoquinolines)\tprincipal sensory nucleus of trigeminal nerve development (Organ or Tissue Function)\treflexed (Psychophysiology)\tcranial nerve morphogenesis (Organism Function)\tStructure of immune system, unspecified (body system)", + "output": "cranial nerve morphogenesis (Organism Function)" + }, + { + "input": "Definition: hexosyltransferase activity described as catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O.\nConcepts: WD1-Living Situation at Interview (Intellectual Product)\tSynthase, PGH (Mixed Function Oxygenases)\tphenanthrol glycosyltransferase activity (Molecular Function)\tburning disorders (Traumatic injury)\tCD8 Antigen Positive Neoplastic Cells Present (CD8 Positive)", + "output": "phenanthrol glycosyltransferase activity (Molecular Function)" + }, + { + "input": "Definition: Cell Component described as a conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.\nConcepts: IVD Test Reagent/Kits, Home Assay, Urine, Chloride (IVD Test Reagent/Kits, Home Assay, Urine)\tgravis (QUALIFIERS FOR SEVERITY OF ILLNESS)\ttaurultame (Organic Chemical)\tSARCOIDOSIS (Rheumatic illness with extraarticular and/or constitutional features (fever, rash, pleurisy,etc) OR Systemic illness with rheumatic manifestation)\tN-terminal acetyltransferase A complex location (N-terminal protein acetyltransferase complex)", + "output": "N-terminal acetyltransferase A complex location (N-terminal protein acetyltransferase complex)" + }, + { + "input": "Definition: something described as ovarian failure, the cause of which is not present at birth.\nConcepts: mitochondrial alpha-ketoglutarate transmembrane transport (alpha-ketoglutarate transport)\tYEAST (Cell Count)\tIslet cell adenocarcinoma (ADENOMAS AND ADENOCARCINOMAS)\tBiological Oxygen Demand Analyses (Laboratory Procedure)\tAcquired Ovarian Failure (Disease or Syndrome)", + "output": "Acquired Ovarian Failure (Disease or Syndrome)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ecdysone 22-phosphate + H2O <=> ecdysone + hydrogenphosphate.\nConcepts: Dasatinib-containing product (D [Preparations])\tBasa (Niger-Congo language)\tTIMP Metallopeptidase Inhibitor 4 wt Allele (Gene or Genome)\tpMX Cancer of the Thyroid v6 (Finding)\tecdysone-phosphate phosphatase activity (phosphoric monoester hydrolase activity)", + "output": "ecdysone-phosphate phosphatase activity (phosphoric monoester hydrolase activity)" + }, + { + "input": "Definition: something described as procedures by which a group of individuals approach and solve their common objectives.\nConcepts: demethylation (Metabolism)\tsocial group process (Social Behavior)\tNeuro QoL Cognitive Function Subdomain (Intellectual Product)\tChondro-4-Sulfatase (Sulfatases)\tStage IVB Hilar Cholangiocarcinoma (Neoplastic Process)", + "output": "social group process (Social Behavior)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as abnormal globulins with unusual thermosolubility characteristics that are found in the urine of patients with multiple myeloma.\nConcepts: INTERFERON-INDUCED PROTEIN 44 (Genes, Regulator)\tCoated Pit, Cell-Membrane (Cell Component)\tmallory tears weiss (Injury of stomach)\tgeraniol:NADP+ oxidoreductase activity (Molecular Function)\tmyeloma globulin (Globulins)", + "output": "myeloma globulin (Globulins)" + }, + { + "input": "Definition: Neonatal Adverse Event described as an adverse event in a newborn characterized by progressive alveolar atelectasis from birth due to an abnormality of synthesis, function or metabolism of surfactant, characterized by respiratory failure and an abnormal chest radiograph showing diffuse reticulogranular densities and air bronchograms.\nConcepts: 1,2-diaminomethylcyclobutane-platinum(II) lactate (Platinum Antineoplastic Compound)\tGPS2 wt Allele (Gene or Genome)\tP53 Gene Inactivation (TP53 Gene Mutation)\tNeonatal Respiratory Distress Syndrome, AE (Finding)\tVitamin B12 Binding Proteins (Amino Acid, Peptide, or Protein)", + "output": "Neonatal Respiratory Distress Syndrome, AE (Finding)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as tyrosine-protein kinase transmembrane receptor ROR1 (937 aa, ~104 kDa) is encoded by the human ROR1 gene. This protein plays a role in receptor type tyrosine kinase-mediated signaling.\nConcepts: Grade 4 Hemorrhoidal hemorrhage (Finding)\tNeurotrophic tyrosine kinase, receptor-related 1 protein, human (Amino Acid, Peptide, or Protein)\tStaging, TNM (Classification)\ttrue cholinesterase activity (Molecular Function)\tAbnormal rhythmic movements of ankle (Finding)", + "output": "Neurotrophic tyrosine kinase, receptor-related 1 protein, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the process of introducing a phosphate group into dCDP to produce a dCTP.\nConcepts: Stage IIIA (Classification)\tCatabolic Pathways for Arginine, Histidine, Glutamate, Glutamine, and Proline (Amino Acid Metabolism Pathway)\tS pombe Proteins (Fungal Proteins)\tGrade 3 Psychosis, CTCAE (Finding)\tdCDP phosphorylation (Molecular Function)", + "output": "dCDP phosphorylation (Molecular Function)" + }, + { + "input": "Definition: Oxidoreductase described as an oxidoreductase that catalyzes the oxidative DEAMINATION of GLYCINE to glyoxylate and AMMONIA in the presence of NAD. In BACTERIA lacking transaminating pathways the enzyme can act in the reverse direction to synthesize glycine from glyoxylate and ammonia and NADH.\nConcepts: lactoperoxidase (Amino Acid, Peptide, or Protein)\tDehydrogenase, Glycine (Amino Acid, Peptide, or Protein)\tBEBQ0210 (Intellectual Product)\tEnhancer of Zeste (Drosophila) Homolog 2 Gene (Gene or Genome)\tquetelet index (Body weight measure)", + "output": "Dehydrogenase, Glycine (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Neoplastic Process described as an atypical teratoid/rhabdoid tumor occurring in children. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C68634\" active clinical trials using this agent.\nConcepts: Alarm, Delayed (Improper Alarm Medical Device Problem)\tPitx2 Transcription Regulation Pathway (Regulatory Pathway)\tN-Myristoylation (Molecular Function)\tChildhood Atypical Teratoid/Rhabdoid Tumor (Neoplastic Process)\thypertrophic scars (Reactive fibrous tissue proliferation)", + "output": "Childhood Atypical Teratoid/Rhabdoid Tumor (Neoplastic Process)" + }, + { + "input": "Definition: DLG1 gene described as human DLG1 wild-type allele is located within 3q29 and is approximately 254 kb in length. This allele, which encodes disks large homolog 1 protein, is involved in both organization of the actin cytoskeleton and coupling of this structure to the cell membrane.\nConcepts: Residual Solvents (Laboratory Procedure)\tMy pet wants to play (Clinical or Research Assessment Question)\tDLG1 wt Allele (Gene or Genome)\tPCM1-JAK2 Fusion Protein Positive (Cell or Molecular Dysfunction)\tPostepileptic confusion (Seizures)", + "output": "DLG1 wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Enzyme described as ATPase WRNIP1 (665 aa, ~72 kDa) is encoded by the human WRNIP1 gene. This protein is involved in both ATP hydrolysis and DNA replication.\nConcepts: Neoplasm, Experimental (In Vitro Model)\tWRNIP1 (Amino Acid, Peptide, or Protein)\tFIGO Stage IIIC (FIGO Stage III)\tAnalyzers, Laboratory, Microbiology (Analyzers, Laboratory)\tAPCH106A (APACHE II Clinical Classification Question)", + "output": "WRNIP1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Molecular Function described as any process that modulates the frequency, rate or extent of 1-deoxy-D-xylulose-5-phosphate synthase activity.\nConcepts: ventricular system development (system development -- biological)\tregulation of 1-deoxyxylulose-5-phosphate synthase activity (regulation of transferase activity)\tMYO1F wt Allele (Gene or Genome)\tBI 754091 (Anti-PD1 Monoclonal Antibody)\tMicrospironema (Treponema)", + "output": "regulation of 1-deoxyxylulose-5-phosphate synthase activity (regulation of transferase activity)" + }, + { + "input": "Definition: Adenocarcinoma of small intestine described as an adenocarcinoma that arises from the duodenum. Histologic variants include mucinous adenocarcinoma and signet ring cell carcinoma.\nConcepts: Urinary Collection Bags, Infant (Medical Device)\texcisional biopsy (Surgical biopsy)\tadenocarcinoma of the duodenum (Adenocarcinoma of small intestine)\t12-methoxyibogamine (Pharmacologic Substance)\tneoplasm - soft tissue blood vessel hemangioendothelioma retiform (locally aggressive or borderline adult vascular tumor)", + "output": "adenocarcinoma of the duodenum (Adenocarcinoma of small intestine)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Rhodococcus equi.\nConcepts: Labor Dystocia (Maternal complications of labour NEC)\thearing loss (Hearing Loss)\tERA (Disease or Syndrome)\tCorynebacterium equi (Rhodococcus species)\tFem stress incontinence (Disease or Syndrome)", + "output": "Corynebacterium equi (Rhodococcus species)" + }, + { + "input": "Definition: something described as a DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.\nConcepts: Rad51B-Rad51C-Rad51D-XRCC2 complex location (DNA recombinase mediator complex)\tMUCL1 gene (Gene or Genome)\twalking behavior (Organism Function)\tMyeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2 (Neoplastic Process)\tstep aerobics grp ea.h (Exercise activity)", + "output": "Rad51B-Rad51C-Rad51D-XRCC2 complex location (DNA recombinase mediator complex)" + }, + { + "input": "Definition: Disease or Syndrome described as condition in which there is a deviation from or interruption of the normal structure or function of the first part of the small intestine extending from the pylorus to the jejunum, the duodenum.\nConcepts: Angiotensin-converting enzyme inhibitor agent (Enzyme Inhibitors)\tGL-R (Amino Acid, Peptide, or Protein)\tSTHAG8 (WNT10B gene)\tduodenal diseases (Diseases of esophagus, stomach and duodenum)\tlowers (Spatial Qualifier)", + "output": "duodenal diseases (Diseases of esophagus, stomach and duodenum)" + }, + { + "input": "Definition: Urate level - finding described as a laboratory test result indicating abnormally high concentration of uric acid in the blood.\nConcepts: Bile Duct Stenosis (Hepatobiliary Disorders, CTCAE)\tPODCI Pediatric Parent-Reported Version - Run Short Distances (PODCI Pediatric Parent-Reported Version Questionnaire Question)\tHeart Murmur Categorized by Phase or Timing (Classification)\televated uric acid (LABORATORY ABNORMALITIES)\taerobic respiration, using ferrous ions as electron donor (Cell Respiration)", + "output": "elevated uric acid (LABORATORY ABNORMALITIES)" + }, + { + "input": "Definition: Homo sapiens described as denotes a person from any of the over 1,000 islands in the central and southern Pacific Ocean bounded by a triangle with its three corners at Hawaii, New Zealand, and Easter Island or a person of that ancestry.\nConcepts: malignant hemangiopericytoma, adult (Hemangiopericytoma, Malignant)\tangiogenin-placental ribonuclease inhibitor complex (protein-containing complex)\tSyringe-Exchange Program (Preventive Health Services)\tchemotherapeutics doxorubicin HCl (Antineoplastic Agents)\tPolynesian, NOS (Oceanian)", + "output": "Polynesian, NOS (Oceanian)" + }, + { + "input": "Definition: Guanine Nucleotide Exchange Factors described as guanine nucleotide exchange factor VAV2 (878 aa, ~101 kDa) is encoded by the human VAV2 gene. This protein plays a role in guanine nucleotide exchange factor activity for Rho family GTPases.\nConcepts: CD19R(EQ)28zeta/EGFRt+ TCM (therapeutic autologous lymphocytes)\talphaPDGF receptor signaling pathway (platelet-derived growth factor receptor signaling pathway)\tDelayed Graft Function (Pathologic Processes)\tVAV-2 (Amino Acid, Peptide, or Protein)\t(2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol transmembrane transport (Cell Function)", + "output": "VAV-2 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Biologically Active Substance described as a subclass of karyopherins that function specifically to import molecules into the nucleus.\nConcepts: regulation of blood coagulation (Organism Function)\tMel-1B-R (Receptor)\tdistal arthrogryposis-mental retardation-characteristic facies syndrome (Disease or Syndrome)\tDid you become confused and start several actions at a time (Intellectual Product)\tImportin (Biologically Active Substance)", + "output": "Importin (Biologically Active Substance)" + }, + { + "input": "Definition: Enediyne Antineoplastic Antibiotic described as an oligosaccharide enediyne antitumor antibiotic isolated from Micromonospora echinospora ssp. Calichensis. Calicheamicin Gamma 1I binds to the minor groove of DNA, resulting in site-specific double-strand breaks and apoptosis.\nConcepts: ESCRT II complex location (Endosomal Sorting Complex Required for Transport Location)\tGrade 1 Immune System Disorders - Other, Specify, CTCAE (Finding)\tHave Lack of Confidence in Insurance Provider (Clinical or Research Assessment Question)\tCalicheamicin Gamma 1I (Antibiotic)\tinternal auditory canal (Structure of petrous part of temporal bone)", + "output": "Calicheamicin Gamma 1I (Antibiotic)" + }, + { + "input": "Definition: Chemo/immuno/hormone Therapy Regimen described as any regimen that can be used for the treatment of melanoma.\nConcepts: Regimen Used to Treat Melanoma (Therapeutic or Preventive Procedure)\tColliculus Inferiors (Segment of midbrain tectum)\tCranial adjustment each adju (Therapeutic or Preventive Procedure)\tnl (SI-derived unit of volume)\tIonization Chambers (Medical Device)", + "output": "Regimen Used to Treat Melanoma (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Oils, Volatile described as spruce.\nConcepts: black spruce (Picea)\tVFQ2A11A (VFQ25-Self Administered Format Questionnaire Question)\tNitrergic Neuron (Neurons)\tTissue Donors (tissue resource/registry)\tanastomotic leak pharynx (Finding of head and neck region)", + "output": "black spruce (Picea)" + }, + { + "input": "Definition: Quantitative Concept described as the highest value in a standard range of pharmacokinetic concentration values.\nConcepts: Aurora B/C kinase inhibitor GSK1070916A (Aurora Kinase Inhibitor)\tPCULOQ (Quantitative Concept)\tTranscription Factor STAT4 (TRANSCRIPTION FACTOR)\tSRp20 (SRSF3 gene)\tMitral valve E-wave deceleration time (Mitral valve feature)", + "output": "PCULOQ (Quantitative Concept)" + }, + { + "input": "Definition: something described as a measurement of the C-terminal fibroblast growth factor 23 in a biological specimen.\nConcepts: Spemann organizer formation at the dorsal lip of the blastopore (Organism Function)\tANSD V1.0 (Clinical or Research Assessment Questionnaire)\tFGF23C (Laboratory Procedure)\tMyeloid Neoplasms with Germline ANKRD26 Mutation (Neoplastic Process)\tSoluble Interleukin-2 Receptor Subunit Alpha Assay (Immunologic Tests)", + "output": "FGF23C (Laboratory Procedure)" + }, + { + "input": "Definition: epithelial cell morphogenesis described as the change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.\nConcepts: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity (racemase and epimerase activity, acting on carbohydrates and derivatives)\tLaryngeal Carcinoma pN2b TNM Finding v8 (Laryngeal Cancer pN2 TNM Finding v8)\tInsulin resistance syndrome (Endocrine Syndrome)\tDMF (Intellectual Product)\tendothelial cell morphogenesis (Cell Function)", + "output": "endothelial cell morphogenesis (Cell Function)" + }, + { + "input": "Definition: Finding described as normal or abnormal findings related to physical, emotional, behavioral, or social development.\nConcepts: regulation of protein localization to non-growing cell tip (Cell Function)\tCRENOLANIB BESYLATE (Organic Chemical)\ttransforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry (Molecular Function)\tHeat-Stress Responses (Cellular Stress Response)\tDevelopmental Finding (Finding)", + "output": "Developmental Finding (Finding)" + }, + { + "input": "Definition: Chlorobenzenes described as a stable, white, crystalline chlorinated hydrocarbon that emits very toxic fumes of carbon monoxide, carbon dioxide, hydrochloric acid and other chlorinated compounds when heated to decomposition. Hexachlorobenzene was used as a fungicide and was also used as a chemical intermediate in the manufacture of dyes, synthesis of organic chemicals, rubber and in wood preservation. Prolonged oral exposure to this substance results in a liver disease with associated skin lesions. Hexachlorobenzene is reasonably anticipated to be a human carcinogen based on association between thyroid, liver and kidney cancer and oral exposure in animals.\nConcepts: Systems, Computer (Manufactured Object)\tLymphoma of Sternum (Neoplastic Process)\tBiopolymer (Polymers)\thcb (Chlorobenzenes)\tUromucoid protein (URINARY PROTEINS AND PROTEINURIAS)", + "output": "hcb (Chlorobenzenes)" + }, + { + "input": "Definition: something described as a measurement of the CXCL9, chemokine (C-X-C motif) ligand 9, in a biological specimen.\nConcepts: Respiratory Secretion Viscosity Alteration (Organ or Tissue Function)\tDiabetic high calorie high protein enteral formula with fiber (Food)\tSCYB9 (Chemokine Measurement)\turanyl nitrate (Uranium and uranium compound)\tsodium ion homeostasis (monovalent inorganic cation homeostasis)", + "output": "SCYB9 (Chemokine Measurement)" + }, + { + "input": "Definition: Allogeneic Lymphocyte described as a population of off the shelf, closely human leukocyte antigen (HLA)-matched allogeneic, ex vivo-expanded cytotoxic T-lymphocytes (CTLs) specifically reactive to human adenovirus (Ad), with potential immunomodulating and anti-adenoviral activities. Upon administration, the allogeneic most closely HLA-matched Ad-specific CTLs may reconstitute Ad-specific CTL responses in patients at risk of developing Ad infections either following allogeneic stem cell transplantation or in Ad-infected immunocompromised hosts. The anti-adenoviral CTLs are provided by a third party donor and not by the allogeneic stem cell transplant donor.\nConcepts: low platelet (Laboratory test result abnormal)\tLeft Lumbar Region (Back)\tMost Closely HLA Matched Third-Party Donor Adenovirus Specific CTLs (Cell)\tDetector Device (Medical Device)\tPrenatal Care brand (Vitamin)", + "output": "Most Closely HLA Matched Third-Party Donor Adenovirus Specific CTLs (Cell)" + }, + { + "input": "Definition: Organic Chemical described as the mesylate salt form of eprosartan, a non-biphenyl, non-tetrazole, nonpeptide angiotensin II antagonist with antihypertensive activity. Eprosartan mesylate antagonizes angiotensin II type I receptors in tissues such as vascular smooth muscle and the adrenal gland. This prevents angiotensin II-induced vasoconstriction and prevents angiotensin II-mediated stimulation of aldosterone secretion by the adrenal cortex, which decreases the excretion of sodium and water and increases the excretion of potassium.\nConcepts: Eprosartan Mesylate (Pharmacologic Substance)\tMSWS-12 (Clinical or Research Assessment Questionnaire)\tlateral area 29a-c (Body Location or Region)\tmonoclonal antibody ABX-EGF (Amino Acid, Peptide, or Protein)\tTemazepam (Benzodiazepines Assay)", + "output": "Eprosartan Mesylate (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as molecular assay reagents intended for use in identifying the acquired presence of three copies of chromosome 8 in a patient sample, rather than the normal two (i.e., trisomy 8). Acquired trisomy 8 is associated with chronic myelogenous leukemia and other chronic myeloproliferative diseases (e.g., polycythemia vera, idiopathic myelofibrosis), myelodysplastic syndromes, and acute nonlymphocytic leukemias.\nConcepts: 14q11-q12 (Cell Component)\tneck edema (Edema)\tCutaneous Apudoma (Skin lesion)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Trisomy 8, Acquired (Medical Device)\tStage IIB (Stage level 2)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Trisomy 8, Acquired (Medical Device)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech.\nConcepts: fear symptoms (Self Concept)\tVacuum Cleaner Artifact (Finding)\ttongue development (sensory organ development)\tPSA Less Than or Equal to 0.2 ng/mL (PSA Level Finding)\tMesodermal mixed tumor (Malignant Mixed Tumor)", + "output": "tongue development (sensory organ development)" + }, + { + "input": "Definition: FACT-P Version 4 Questionnaire Question described as functional Assessment of Cancer Therapy-Prostate Version 4 (FACT-P Version 4) Additional Concerns: I have aches and pains that bother me.\nConcepts: Thais (Mongoloid population)\tNCCN-FACT-FPSI 17 Version 2 - I Have a Lack of Energy (NCCN-FACT-FPSI 17 Version 2 Questionnaire Question)\tanti-CD20-engineered toxin body MT-3724 (CD20-targeting Agent)\tFAC02330 (Intellectual Product)\tComamonas terrigena (ex Hugh 1962) De Vos et al. 1985 emend. Wauters et al. 2003 (Comamonas)", + "output": "FAC02330 (Intellectual Product)" + }, + { + "input": "Definition: Congenital Abnormality described as a developmental abnormality characterized by the complex protrusion of viscera outside the abdominal wall.\nConcepts: Tension Pneumothorax Training Simulators (Simulators, Training)\tCELOSOMY (Congenital Abnormality)\tFIP1L1 cleavage and polyadenylation specific factor subunit (Genes, Regulator)\tpolyol transmembrane transporter activity (Molecular Function)\tMRTIVIFO (Temporal Concept)", + "output": "CELOSOMY (Congenital Abnormality)" + }, + { + "input": "Definition: Nitroso Compounds described as a class of compounds in which the core molecule is R-NO, where R is UREA.\nConcepts: I can think of many ways to get the things in life that are important to me (Intellectual Product)\tAplysias (Aplysiidae)\tCDISC Questionnaire MMRC Test Name Terminology (CDISC Questionnaire Terminology)\tcellulose metabolic process (Molecular Function)\tnitrosoureas (Alkylating Agents)", + "output": "nitrosoureas (Alkylating Agents)" + }, + { + "input": "Definition: Biologically Active Substance described as insulin-like growth factor-binding protein 5 (272 aa, ~31 kDa) is encoded by the human IGFBP5 gene. This protein is involved in promoting increased half-life of and modulating receptor binding by insulin-like growth factors.\nConcepts: Canister Dosing Unit (Quantitative Concept)\tWhole-Body Gamma Camera Systems (Scanning Systems, Gamma Camera)\tPhenotype - finding (Science of genetics)\tOtospongiosis syndrome (Disease or Syndrome)\tIGF-Binding Protein 5 (Insulin-Like Growth-Factor-Binding Proteins)", + "output": "IGF-Binding Protein 5 (Insulin-Like Growth-Factor-Binding Proteins)" + }, + { + "input": "Definition: something described as analyzing the position of a client's body with respect to surrounding space to determine his or her postural flaws that may be affecting muscles that move limbs and maintain balance. Service is billed in 15-minute increments.\nConcepts: T-Cell Leukemia/Lymphoma 6 Long Non-Coding RNA (Amino Acid, Peptide, or Protein)\tdata monitoring (Functional Concept)\tommaya reservoir (Ventricular reservoir)\tMirror movements disorder (Central Nervous System)\tPostural analysis test each 15 minutes (Therapeutic or Preventive Procedure)", + "output": "Postural analysis test each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Cell Function described as the process by which a virion attaches to a host cell by binding to a receptor on the host cell surface that does not mediate or trigger entry into the host cell. This binding is typically reversible and enhances significantly infectivity by concentrating the virus in the vicinity of its entry receptors, or bringing it to an organ in which its target cells are located.\nConcepts: viral attachment to host adhesion receptor (receptor-mediated virion attachment to host cell)\tZinc Protoporphyrin (Protoporphyrin measurement)\tANTISERUM, HAI, RUBEOLA (Indicator, Reagent, or Diagnostic Aid)\tCardiac Pacemaker Undersensing (Pacing Inadequately)\tTrial Statistician (Statistician)", + "output": "viral attachment to host adhesion receptor (receptor-mediated virion attachment to host cell)" + }, + { + "input": "Definition: Health Care Activity described as the act of presenting a survey, questionnaire, or similar item to a person to obtain their responses.\nConcepts: 2-acetylamino-2-deoxy-D-glucose kinase activity (carbohydrate kinase activity)\tClinical Trial Monitoring Plan (Intellectual Product)\tstreptoccocal; pneumonia (Pneumonia caused by Gram positive bacteria)\tExemestane/Trastuzumab/Lapatinib (Regimen Used to Treat Breast Carcinoma)\tSurvey Administration (Health Care Activity)", + "output": "Survey Administration (Health Care Activity)" + }, + { + "input": "Definition: Organ component described as organ component constituted by specialized tissues which are organized into acini, lobules, segments, and lobes, or corticomedullary units and supported by stroma. Examples: lung parenchyma, liver parenchyma, parenchyma of kidney.\nConcepts: Severe feeding difficulties, failure to thrive, microcephaly due to ASXL3 deficiency syndrome (Autosomal dominant hereditary disorder)\tArformoterol tartrate (Bronchodilators, Sympathomimetic)\tnegative regulation of epinephrine uptake (negative regulation of transport)\tclavicle resection (Procedure on clavicle)\tparenchyma (Organ component)", + "output": "parenchyma (Organ component)" + }, + { + "input": "Definition: Acidosis, Respiratory described as abnormally elevated blood carbon dioxide (CO2) level.\nConcepts: BLOOD CO2 INCREASED (Measurement finding above reference range)\tPowder for conventional release cutaneous solution (Topical Powder)\tGI (Nutritive Value)\tCongenital onset (Age of Onset)\tDevice.reprocessedDeviceCode (Reprocessed Code)", + "output": "BLOOD CO2 INCREASED (Measurement finding above reference range)" + }, + { + "input": "Definition: something described as catalysis of the reaction: vanillate + ATP + amino acid = vanillate amino acid conjugate + AMP + diphosphate.\nConcepts: Full-time work (Employed)\tGrade 3 Ear pain (Finding)\tPortuguese Sheepdog (Mammal)\tvanillate amino acid synthetase activity (acid-D-amino acid ligase activity)\tPackageIdentifier.typeCode (Type Code)", + "output": "vanillate amino acid synthetase activity (acid-D-amino acid ligase activity)" + }, + { + "input": "Definition: Stage IV Liver Cancer described as stage IVA carcinoma of the liver according to the American Joint Committee on Cancer, 7th and 8th editions.\nConcepts: Chemical Structure as SMILES String (Intellectual Product)\tNurse comprehensive new home-visit 60 minutes (Health Care Activity)\tStage IVA Liver Cancer (Stage IV Liver Cancer)\tBony metastasis (Secondary malignant neoplasm of bone)\tActivation Problem (Finding)", + "output": "Stage IVA Liver Cancer (Stage IV Liver Cancer)" + }, + { + "input": "Definition: Recurrent infections described as increased susceptibility to protozoan infections, as manifested by recurrent episodes of protozoan infection.\nConcepts: down regulation of epidermal growth factor receptor signalling pathway involved in heart process (negative regulation of epidermal growth factor receptor signaling pathway)\tAcute Illnesses Nursing (Biomedical Occupation or Discipline)\tBrodmann area (Brain region)\tEvery six weeks (Temporal Concept)\tRecurrent protozoan infections (Recurrent infections)", + "output": "Recurrent protozoan infections (Recurrent infections)" + }, + { + "input": "Definition: Intellectual Product described as st. George's Respiratory Questionnaire for COPD Patients (SGRQ-C) (Jones PW, Quirk FH, Baveystock CM, and Littlejohns PA. Self-complete measure of health status for chronic airflow limitation. The St. George's Respiratory Questionnaire. Am Rev Respir Dis. 1992 Jun; 145(6):1321-7).\nConcepts: Blades, Electric/Pneumatic Saw, Reciprocating (Medical Device)\tmolecular diagnostic method (Molecular Biology Research Technique)\tSt. George's Respiratory Questionnaire for Chronic Obstructive Pulmonary Disease Patients (Clinical or Research Assessment Questionnaire)\tStage IVA Rectal Cancer (Neoplastic Process)\tMesonephric structure (embryo and fetus)", + "output": "St. George's Respiratory Questionnaire for Chronic Obstructive Pulmonary Disease Patients (Clinical or Research Assessment Questionnaire)" + }, + { + "input": "Definition: Manufactured Object described as electric cords designed for temporarily powering devices used at a distance beyond the reach of their own power cords. These devices typically consist of a flexible cable with a plug for connection to the main power receptacle and one or more sockets (female connectors) at the other end for insertion of the devices to be powered. Electrical extension cords may include safety improving capabilities such as inclusion of fuses, polarized plugs and sockets, and ground-fault circuit interrupters. The cords are available for indoor or outdoor and wet conditions use.\nConcepts: MOH (Language)\tCHART-SF Interview Version - Hours Out of Bed per Day (CHART-SF Interview Version Questionnaire Question)\tCurettes, Surgical, Uterine, Placenta/Ovum (Curettes, Surgical, Uterine)\tExtension Cords (Manufactured Object)\tEZN 3042 (Antisense Oligonucleotides)", + "output": "Extension Cords (Manufactured Object)" + }, + { + "input": "Definition: something described as a chromosome band present on 11q\nConcepts: Prostate Cancer cM1a TNM Finding v8 (Finding)\tAlcohol Drinking Attitudes (Finding relating to alcohol drinking behavior)\tpotassium ion import across plasma membrane (potassium ion transmembrane transport)\tSpiritual nurse religious practice facilitation individual each 15 minutes (Health Care Activity)\t11q13.3 (Chromosome band)", + "output": "11q13.3 (Chromosome band)" + }, + { + "input": "Definition: GGT Increased, CTCAE described as >2.5-5.0 x ULN if baseline was normal; >2.5-5.0 x baseline if baseline was abnormal\nConcepts: up-regulation of potassium ion transmembrane transporter activity (positive regulation of potassium ion transmembrane transport)\t(R)-mevalonate:NAD+ oxidoreductase (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tleaf vascular tissue pattern formation (Organism Function)\tGrade 2 GGT increased (Finding)\tDecreased plasma free carnitine (LABORATORY ABNORMALITIES)", + "output": "Grade 2 GGT increased (Finding)" + }, + { + "input": "Definition: something described as this gene plays a role in transcriptional activation in response to cytoskeletal changes and inhibits cellular proliferation.\nConcepts: Acylglycine (Laboratory Procedure)\tZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 17 (Transcription Regulation Gene)\tRectum protrudes through anus (Anorectal Diseases)\tIntracorneal (RouteBySite)\tLower Lobe of the Lung (Structure of lobe of lung)", + "output": "ZINC FINGER- AND BTB DOMAIN-CONTAINING PROTEIN 17 (Transcription Regulation Gene)" + }, + { + "input": "Definition: something described as the determination of the amount of complement required to lyse 100 percent of red blood cells in a biological specimen.\nConcepts: Complement CH100 Measurement (Laboratory Procedure)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, HSD17B4 (Medical Device)\tEndometrial neoplasia (location of neoplasm of uterus)\tGrade 4 Bullous dermatitis (Bullous Dermatitis, CTCAE)\tColorectal MVHP (Colorectal hyperplastic polyp)", + "output": "Complement CH100 Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: something described as mitochondria participate in apoptotic signaling pathways through the release of mitochondrial proteins into the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase pathway. Smac/DIABLO is released from mitochondria and inhibits IAP proteins that normally interact with caspase-9 to inhibit apoptosis. Apoptosis regulation by Bcl-2 family proteins occurs as family members form complexes that enter the mitochondrial membrane, regulating the release of cytochrome c and other proteins. TNF family receptors that cause apoptosis directly activate the caspase cascade, but can also activate Bid, a Bcl-2 family member, which activates mitochondria-mediated apoptosis. Bax, another Bcl-2 family member, is activated by this pathway to localize to the mitochondrial membrane and increase its permeability, releasing cytochrome c and other mitochondrial proteins. Bcl-2 and Bcl-xL prevent pore formation, blocking apoptosis. AIF (apoptosis inducing factor) is another mitochondrial factor that is released into the cytoplasm to induce apoptosis. AIF-induced apoptosis is important during development but is not caspase dependent.\nConcepts: Ventricle, Left (Heart)\tArch Tracing Units (Medical Device)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, MEFV (Medical Device)\tmilliequivalent per kilogram (Equivalents per unit mass)\tRole of Mitochondria in Apoptotic Signaling (Apoptosis Regulation Pathway)", + "output": "Role of Mitochondria in Apoptotic Signaling (Apoptosis Regulation Pathway)" + }, + { + "input": "Definition: Retinopathy of Prematurity described as retinopathy which extends centrifugally from the edge of zone I to the nasal ora serrata.\nConcepts: ROP zone II (Disease or Syndrome)\tkidney anlage formation (Organ or Tissue Function)\tdysautonomia (Autonomic nervous system disorders)\tpositive regulation of uracil import across plasma membrane (positive regulation of response to drug)\tcellular divalent inorganic anion homeostasis (cellular anion homeostasis)", + "output": "ROP zone II (Disease or Syndrome)" + }, + { + "input": "Definition: Pharmacologic Substance described as a broad-acting, apoptosis-inducing, small molecule with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, apoptosis inducer MPC-2130 exhibits proapoptotic activities in tumor cells, including membrane phosphatidylserine externalization, release of cytochrome C from mitochondria, caspase activation, cell condensation, and DNA fragmentation. In addition, because this agent is not a substrate for several types of multidrug resistance (MDR) ABC superfamily transporters, such as P-glycoprotein 1 (MDR-1), multidrug resistance-associated protein 1 (MRP1), and breast cancer resistance protein 1 (BCRP1/ABCG2), it may be useful in treating MDR tumors that express these particular MDR efflux pumps.\nConcepts: apoptosis inducer MPC-2130 (Pharmacologic Substance)\tManagement of concentration of enteral nutrition (Enteral feeding management)\tCnidarian Venom (Venoms)\tCytometers, Automated, Flow, Sorting (Medical Device)\tGrade 2 Neonatal Sinus Tachycardia, AE (Finding)", + "output": "apoptosis inducer MPC-2130 (Pharmacologic Substance)" + }, + { + "input": "Definition: CPTAC Responses described as a response that radiation was not administered as an additional treatment for a new tumor event.\nConcepts: 4-amino-4-deoxy-beta-L-arabinose-lipid A biosynthesis (Molecular Function)\tSDTM-VSTESTCD (Intellectual Product)\tSmoothing (Research Activity)\tMITOGEN-ACTIVATED PROTEIN KINASE KINASE 4 (Gene or Genome)\tRadiation Was Not Administered as an Additional Treatment for a New Tumor Event (Finding)", + "output": "Radiation Was Not Administered as an Additional Treatment for a New Tumor Event (Finding)" + }, + { + "input": "Definition: intrauterine disorder described as expulsion of the product of FERTILIZATION before completing the term of GESTATION and without deliberate interference.\nConcepts: Product containing dimethyl sulfoxide (Organic Chemical)\tepithelial keratitis punctate (epithelial keratitis)\taesculus hippocastanum/white (Flower Essences)\tIncrease or decrease in manganese content of the diet. (Therapeutic or Preventive Procedure)\tspontaneous abortion (Pregnancy Complications)", + "output": "spontaneous abortion (Pregnancy Complications)" + }, + { + "input": "Definition: Population Group described as denotes the inhabitants of the Marshall Islands, a person from there, or their descendants elsewhere.\nConcepts: Hernia, Abdominal Wall (Hernia of abdominal cavity)\tDisassembly (Activity)\tMarshallese race (Oceanian)\tcarmegliptin (Dipeptidyl Peptidase-4 Inhibitor)\tAbility to Tie a Tie or Bow at the Neck of a Blouse (Intellectual Product)", + "output": "Marshallese race (Oceanian)" + }, + { + "input": "Definition: Personality Processes described as unconscious process used by an individual or a group of individuals in order to cope with impulses, feelings or ideas which are not acceptable at their conscious level; various types include reaction formation, projection and self reversal.\nConcepts: Intracellular Communication Induction (Cell Function)\tPODCI Adolescent Parent-Reported Version - Outdoor Limited by: Dislike (Intellectual Product)\tMechanisms, Defense (Behavior and Behavior Mechanisms)\tSeverity Score 7 (Clinical or Research Assessment Answer)\tMeristems (Plant)", + "output": "Mechanisms, Defense (Behavior and Behavior Mechanisms)" + }, + { + "input": "Definition: Methods described as techniques, procedures, and routes (e.g., oral, intravenous) of administration of drugs (in experimental or therapeutic contexts) including dosage forms (e.g., liquids, tablets), frequency, and duration of drug administration. Used only when methodological aspects of administering drugs are discussed.\nConcepts: upregulation of xylose catabolism to ethanol (positive regulation of pentose catabolic process to ethanol)\tZigadenus, NOS (Plant)\tD77 FAMILY RUTACEAE (Angiosperm)\tliposomal eribulin mesylate (Pharmacologic Substance)\tdrug administration method (Functional Concept)", + "output": "drug administration method (Functional Concept)" + }, + { + "input": "Definition: Biologically Active Substance described as hepatocyte nuclear factor 1-beta (557 aa, ~61 kDa) is encoded by the human HNF1B gene. This protein is a liver-specific transcription factor. Truncated forms of the protein are involved in the pathology of maturity-onset of diabetes, type 5.\nConcepts: Hour Times Picogram per Milliliter per Milligram (Measurement Unit Description)\tNanograms per milliliter per hour (Unit of Dose Calculation)\tTCF-2 (TRANSCRIPTION FACTOR)\tGrowth Factor Receptor-Bound Protein-2 (Biologically Active Substance)\tCLAW, FOREIGN BODY, BRONCHOSCOPE (Medical Device)", + "output": "TCF-2 (TRANSCRIPTION FACTOR)" + }, + { + "input": "Definition: something described as greyleg goose species\nConcepts: Device Tracking and Disposition (Intellectual Product)\tgraylag goose (Geese)\tFAC100-Limit: Walking Up 10 Stairs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)\t6\u03b1-Methyl-17-acetoxy progesterone (Drug allergens)\tGalega officinalis / goat's rue (Organic Chemical)", + "output": "graylag goose (Geese)" + }, + { + "input": "Definition: something described as an acute form of rhabdomyolysis.\nConcepts: Gastric Adenoma (Neoplastic Process)\tmegaspore mother cell differentiation (Cell Function)\tRhabdomyolysis, acute (Rhabdomyolysis)\t22: 40341854-40384543 (Chromosome 22 Physical Location)\tRuth L. Kirschstein National Research Service Awards for Individual Predoctoral Fellows (Individual National Research Service Award)", + "output": "Rhabdomyolysis, acute (Rhabdomyolysis)" + }, + { + "input": "Definition: Low grade glioma described as low grade glioma that is not amenable to surgical removal.\nConcepts: FLJ38614 (CHD2 gene)\tUnresectable Low-Grade Glioma (Neoplastic Process)\t(L/day)/m2 (Quantitative Concept)\tTEMPERATURE BODY DECREASE (NUTRITIONAL-METABOLIC PATTERNS)\tTSCYC - Acting Like He or She Was in Trance (TSCYC Questionnaire Question)", + "output": "Unresectable Low-Grade Glioma (Neoplastic Process)" + }, + { + "input": "Definition: Oxides described as an oxide of aluminum, occurring in nature as various minerals such as bauxite, corundum, etc. It is used as an adsorbent, desiccating agent, and catalyst, and in the manufacture of dental cements and refractories.\nConcepts: Anti-L-Plastin (Antibodies)\tAluminum oxide-containing product (metal oxide)\tmotoneuron axon guidance (Cell Function)\tCunninghamella species (Cunninghamellaceae)\tICREV (Pulmonary function tests)", + "output": "Aluminum oxide-containing product (metal oxide)" + }, + { + "input": "Definition: something described as human TP53BP1 wild-type allele is located within 15q15-q21 and is approximately 103 kb in length. This allele, which encodes tumor suppressor p53-binding protein 1, may be involved in the regulation of both mitosis and nonhomologous end joining after DNA damage.\nConcepts: Cardiotocographs, Intrapartum (Medical Device)\tFlat nasal root (Malformation of the nose)\tactin filament bundle of filopodium (Cell Component)\tFLJ41424 (Gene or Genome)\tProviruses (Nucleic Acid, Nucleoside, or Nucleotide)", + "output": "FLJ41424 (Gene or Genome)" + }, + { + "input": "Definition: something described as an abnormality of the morphology of the epidermis.\nConcepts: Crotylaldehyde (Organic Chemical)\tViscosities, Blood (Cardiovascular Physiological Phenomena)\tantigen transport by M cells in MALT (Transcytosis)\tIGKV1D-13 wt Allele (Gene or Genome)\tAbnormality of epidermal morphology (Abnormality of skin morphology)", + "output": "Abnormality of epidermal morphology (Abnormality of skin morphology)" + }, + { + "input": "Definition: Cell Viability Process described as processes that promote, sustain, and preserve cell viability.\nConcepts: Ginseng, asian (Pharmacologic Substance)\tPostneoadjuvant Therapy Stage I Esophageal Squamous Cell Carcinoma AJCC v8 (Esophageal Squamous Cell Carcinoma by AJCC v8 Postneoadjuvant Therapy Stage)\tDactinomycinum (Antibiotics, Antineoplastic)\tSpindle Assembly Interaction (Binding)\tCell Maintenance (Cell Function)", + "output": "Cell Maintenance (Cell Function)" + }, + { + "input": "Definition: Eutheria described as the taxonomic order of mammals which include hares, rabbits and pikas.\nConcepts: NAD(H) phosphate (high energy compound)\tHAMD-17 - Insight (Intellectual Product)\tLagomorphs (Lagomorpha)\tNeuromuscular (Anatomy Qualifier)\tAdvanced Practice Nurse (Professional or Occupational Group)", + "output": "Lagomorphs (Lagomorpha)" + }, + { + "input": "Definition: positive regulation of multicellular organismal process described as any process that activates or increases the frequency, rate or extent of the regulated release of juvenile hormone.\nConcepts: Focal T2 hypointense brainstem lesion (Abnormal brainstem MRI signal intensity)\tHigh glycine levels in cerebrospinal fluid (Abnormal CSF glycine concentration)\tSwallowing status: esophageal phase (Swallowing status)\tup regulation of juvenile hormone secretion (positive regulation of multicellular organismal process)\tAldolase, patient value (Laboratory: muscle and liver enzymes)", + "output": "up regulation of juvenile hormone secretion (positive regulation of multicellular organismal process)" + }, + { + "input": "Definition: Geographic Area described as a country in central Asia, northwest of China. The capital is Astana.\nConcepts: CRISIS HYPERTENSIVE (Hypertensive disease)\tBloom (Multiple congenital anomalies)\tPneumo Secretory Protein 2 (Amino Acid, Peptide, or Protein)\tEsophagostomy route (Spatial Concept)\tKazakh SSR (USSR)", + "output": "Kazakh SSR (USSR)" + }, + { + "input": "Definition: Metabolic Diseases described as abnormally high level of calcium in the urine.\nConcepts: FAC07541 (FACT-COG Version 3 Questionnaire Question)\tOrganization Identifier Primary Indicator (Qualitative Concept)\tElevated urine calcium levels (Disorder calcium)\tlarval burrowing behavior (Individual Behavior)\tAnnotated Tissue (Annotation)", + "output": "Elevated urine calcium levels (Disorder calcium)" + }, + { + "input": "Definition: something described as the generation of offspring by living organisms.\nConcepts: ovary development (Organ or Tissue Function)\treproductions (Reproductive process)\tSealant matrix (Biomedical or Dental Material)\tGrade 1 Pelvic Pain, CTCAE (Finding)\tRETRIEVING (Health Care Activity)", + "output": "reproductions (Reproductive process)" + }, + { + "input": "Definition: Organic Chemical described as a class of dietary steroids having a hydrocarbon side-chain of 8-10 carbons at the 17-beta position and a hydroxyl group (-OH) at the 3-beta position.\nConcepts: Advair HFA (Pharmacologic Substance)\tMAGE-A3 (Immunologic Factor)\tDietary Sterol (Dietary Steroid)\tOsteogenic sarcoma, NOS (Sarcoma - category)\tProstaglandin PGF2 alpha tromethamine (Prostaglandins F)", + "output": "Dietary Sterol (Dietary Steroid)" + }, + { + "input": "Definition: something described as a microscopy staining method that utilizes lead citrate, a mixture of lead nitrate and sodium citrate, and has applications for electron microscopy staining.\nConcepts: Neuroectodermal Tumors, Primitive (Malignant neuroendocrine neoplasm, neural)\tLEAD CITRATE STAIN (Laboratory Procedure)\tNaevus syringocystadenomatosus papilliferus (Neoplasms)\tKILOGRAM (Quantitative Concept)\tLIC-2 (Gene or Genome)", + "output": "LEAD CITRATE STAIN (Laboratory Procedure)" + }, + { + "input": "Definition: Procedure on intestine described as procedures performed on the intestines, used in the treatment of disease, injuries, or deformities; includes excision of all or portions of the intestines.\nConcepts: surgery intestine (Operation on abdominal region)\tembolism (Thromboembolism)\tOil, NOS (Substance)\tRB transcriptional corepressor like 2 (Transcription factor genes)\tDara-Vd (Therapeutic or Preventive Procedure)", + "output": "surgery intestine (Operation on abdominal region)" + }, + { + "input": "Definition: Visual Cortex - rodent described as one of ten visual areas in the rat ( Swanson-2004 ). See visual cortex (rodent).\nConcepts: Quadrantectomy (Excision or destruction of breast tissue, not otherwise specified)\tALDOSTERONISM (Aldosterone disorder)\tautoimmune antibody (Functional Immunologic Units)\tProtomer (Amino Acid, Peptide, or Protein)\trostrolateral visual area (Body Part, Organ, or Organ Component)", + "output": "rostrolateral visual area (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor.\nConcepts: Persistence (Dispositions and intra-personal functions)\tStents, Pancreatic, Metallic, Balloon-Expandable (Stents, Pancreatic, Metallic)\tfatty acid homeostasis (anion homeostasis)\tTFIIA-class transcription factor binding (RNA polymerase II general transcription initiation factor binding)\tDefibrillator/Pacemaker/Physiologic Monitors (Defibrillators)", + "output": "TFIIA-class transcription factor binding (RNA polymerase II general transcription initiation factor binding)" + }, + { + "input": "Definition: something described as more than two clockwise hair whorls.\nConcepts: Dilated semicircular canal (Morphological abnormality of the semicircular canal)\tSupernumary hair swirls (Finding)\tAcetylcholine Receptor, Nicotinic (Amino Acid, Peptide, or Protein)\tX-linked mental retardation 27 (Disease or Syndrome)\tEarly Term (Finding)", + "output": "Supernumary hair swirls (Finding)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in cell-cell adhesion and cellular differentiation in the nervous system.\nConcepts: alpha-N-catenin (Gene or Genome)\tPDGF receptor-ligand complex location (Cell Component)\tintermediolateral visual area (Visual Cortex - rodent)\tHypoplastic Congenital Anemia (Red blood cell disorder)\tAmino Acids, Branched Chain (Biologically Active Substance)", + "output": "alpha-N-catenin (Gene or Genome)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate.\nConcepts: atrial heart myofibril development (Organ or Tissue Function)\tLugano Classification Stage IIE Childhood Hodgkin Lymphoma AJCC v8 (Neoplastic Process)\tIL122340 (Laboratory Procedure)\tMice, Knock out (Mice, Mutant Strains)\tDoxD (oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor)", + "output": "DoxD (oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the removal of a methyl group from a substrate.\nConcepts: FOCAL ADHESION KINASE 1 (Non-Receptor Tyrosine Kinase Gene)\tdemethylase activity (enzyme activity)\tchaenomelis/mu gua (Plant)\t7: 150215599-150211356 (Chromosome 7 Physical Location)\tsulfate transporting ATPase activity (ATPase-coupled inorganic anion transmembrane transporter activity)", + "output": "demethylase activity (enzyme activity)" + }, + { + "input": "Definition: something described as integrin beta-1 (798 aa, ~88 kDa) is encoded by the human ITGB1 gene. This protein plays a role in leukocyte migration, signal transduction, ligand binding and cell adhesion.\nConcepts: Lung Mucinous Adenocarcinoma In Situ (Lung Adenocarcinoma In Situ)\tADCCPS (Intellectual Product)\tIron Regulatory Protein (Proteins)\tPQL0522 (Intellectual Product)\tAntigen CD29 (Amino Acid, Peptide, or Protein)", + "output": "Antigen CD29 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Intraabdominal hemorrhage described as bleeding from the gastric wall.\nConcepts: COUNTER (BETA, GAMMA) FOR CLINICAL USE (Medical Device)\tEmbryonic Lethal, Abnormal Vision, Drosophila, Homolog-Like 1 (RNA-Binding Proteins)\tAbnormal proportion of marginal zone B cells (Abnormal proportion of memory B cells)\tHAEMORRHAGE GASTRIC (Gastrointestinal Hemorrhage)\tDecigram (Quantitative Concept)", + "output": "HAEMORRHAGE GASTRIC (Gastrointestinal Hemorrhage)" + }, + { + "input": "Definition: MAP Kinase Cascade described as any MAPK cascade that is involved in ascospore formation.\nConcepts: Brand (Name)\tmitogen-activated protein kinase cascade involved in ascospore biosynthesis (MAP Kinase Cascade)\tDelayed Release Dose Form (Modified Release Dosage Form)\tGDS0106 (GDS Questionnaire Question)\tCarcinoma of sebaceous gland (Carcinoma, Skin Appendage)", + "output": "mitogen-activated protein kinase cascade involved in ascospore biosynthesis (MAP Kinase Cascade)" + }, + { + "input": "Definition: Connective tissue by site described as lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.\nConcepts: Azathioprine Sodium (A [Preparations])\t'' (Unit of Plane Angle Measurement)\tCORNEAL STROMA (Structure of soft tissues of head)\tsesquisabinene synthase activity (Molecular Function)\tC-SSRS Children's Since Last Visit - Description of Non-Specific Active Suicidal Thoughts (Intellectual Product)", + "output": "CORNEAL STROMA (Structure of soft tissues of head)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Clinical Chemistry, Calibration described as clinical chemistry reagents intended to establish points of reference (i.e., calibrate) in chemical and/or enzymatic assays used in the determination of enzyme (e.g., aldolase, creatine kinase) content in a sample of a body fluid.\nConcepts: Software, Laboratory Analysis (Intellectual Product)\tIVD Test Reagent/Kits, Clinical Chemistry, Calibration, Enzyme Test (IVD Test Reagent/Kits, Clinical Chemistry, Calibration)\tImmature Lymphocytes (Laboratory Procedure)\tCRQ02-Feeling Emotional (CRQ-SAS Follow-Up Administration Version Questionnaire Question)\t3-hydroxyphenylacetate breakdown (3-hydroxyphenylacetate metabolic process)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Calibration, Enzyme Test (IVD Test Reagent/Kits, Clinical Chemistry, Calibration)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as one of two potential parts of the trapezoid nucleus in the human. Separated by an indistinct boundary, the other is the lateral trapezoid nucleus ( Crosby-1962 ). The existence of the trapezoid nucleus in the human is disputed ( Bazwinsky-2003 ).\\r\\n\nConcepts: SF-36 v2.0 Standard - Question 3b (SF36 v2 0 Standard Questionnaire Question)\tmedial trapezoid nucleus (Body Part, Organ, or Organ Component)\tMalate (Organic Chemical)\tcombined oxidative phosphorylation defect type 9 (Autosomal recessive hereditary disorder)\tCaveolae (Membrane invagination, labile)", + "output": "medial trapezoid nucleus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Neoplastic Process described as a leiomyosarcoma that arises from the bladder. It is the most common type of bladder sarcoma in adults.\nConcepts: Alpha-2C Adrenergic Receptor (Amino Acid, Peptide, or Protein)\tUHDR1-Since Last Assessment Opinion (Intellectual Product)\tcollagen type I, alpha 1 chain (Biologically Active Substance)\tBladder Leiomyosarcoma (Neoplastic Process)\tInjectors, Contrast Media, Angiography (Injectors, Contrast Media)", + "output": "Bladder Leiomyosarcoma (Neoplastic Process)" + }, + { + "input": "Definition: Structure of culmen described as one of two parts of the culmen in an alternate segmentation of the vermis of the cerebellum; the other is lobule IV ( Carpenter-1983, Swanson-1998 ).\nConcepts: Systemic chondromalacia -RETIRED- (Disease or Syndrome)\tFlood Source (Instrument - device)\tHistory of stillbirth (Pregnancy History)\tV (Structure of culmen)\tfractured leg (Injury of unspecified body region)", + "output": "V (Structure of culmen)" + }, + { + "input": "Definition: Congenital Abnormality described as an inherited syndrome of skeletal and retinal malformations with early blindness as well as cataracts and retinal detachment.\nConcepts: Recurrent Primary Vitreoretinal Diffuse Large B-Cell Lymphoma (Recurrent Primary Diffuse Large B-Cell Lymphoma of the Central Nervous System)\tRAB5C, member of RAS oncogene family (Gene or Genome)\tRotavirus Vaccines (Viral Vaccines)\tOSD - Ocular skeletal dysplasia (Congenital anomaly of skeletal bone)\tFatty Acid 12:1 (Organic Chemical)", + "output": "OSD - Ocular skeletal dysplasia (Congenital anomaly of skeletal bone)" + }, + { + "input": "Definition: RNA surveillance described as the set of processes involved in identifying and degrading defective or aberrant RNAs within the nucleus.\nConcepts: nuclear aberrant RNA catabolic process (RNA surveillance)\taracepril (Organic Chemical)\tMFILARIA (Laboratory Procedure)\tNeoplastic Plasma Cells Greater than 30 Percent of Bone Marrow Nucleated Cells (Laboratory or Test Result)\tD-mannitol:ferricytochrome-c 2-oxidoreductase activity (Molecular Function)", + "output": "nuclear aberrant RNA catabolic process (RNA surveillance)" + }, + { + "input": "Definition: Keratosis described as a form of hyperkeratosis characterized by thickening of the cornified layer without retained nuclei. []\nConcepts: Vicias (Vicia)\t1,2,3-tribromopropane metabolism (halogenated hydrocarbon metabolic process)\tConsciousness (Cognition)\tZanthosoma (Araceae)\tOrthokeratotic hyperkeratosis (Hyperkeratosis)", + "output": "Orthokeratotic hyperkeratosis (Hyperkeratosis)" + }, + { + "input": "Definition: something described as this gene plays a role in signal transduction, apoptosis and regulation of cell growth.\nConcepts: transmethylation (Methylation)\ttRNA-specific 2-thiouridylase activity (Molecular Function)\tcaveolin 1, caveolae protein, 22kDa (Structural gene)\tpositive regulation of mitotic spindle elongation (Cell Function)\tFACT-LYM Version 4 - I Have Trouble Sleeping at Night (FACT-LYM Version 4 Questionnaire Question)", + "output": "caveolin 1, caveolae protein, 22kDa (Structural gene)" + }, + { + "input": "Definition: Atrophic described as an autosomal recessive syndrome occurring principally in females, characterized by the presence of reticulated, atrophic, hyperpigmented, telangiectatic cutaneous plaques, often accompanied by juvenile cataracts, saddle nose, congenital bone defects, disturbances in the growth of HAIR; NAILS; and TEETH; and HYPOGONADISM.\nConcepts: corticosterone secretion (glucocorticoid secretion)\thigh-dose radiation (Local Therapy)\tOABQ0113 (OAB-q Questionnaire Question)\tQS-WPAI-SHP TESTCD (Intellectual Product)\tRothmund-Thomson syndrome (Neonatal disorder)", + "output": "Rothmund-Thomson syndrome (Neonatal disorder)" + }, + { + "input": "Definition: Intellectual Product described as asthma Daytime Symptom Diary v1.0 - Please rate your cough at its worst since you got up this morning.\nConcepts: Articulatio coxofemoralis (Joint structure of pelvis)\tHYPOCHOLESTEROLAEMIA (Disease or Syndrome)\tADSD0106 (ADSD Version 1.0 Questionnaire Question)\tElevated left atrial pressure (Finding)\tAT-Hook Transcription Factor wt Allele (Gene or Genome)", + "output": "ADSD0106 (ADSD Version 1.0 Questionnaire Question)" + }, + { + "input": "Definition: Cancer TNM Vessel Invasion Finding Category described as presence of lymphovascular invasion unknown or indeterminate.\nConcepts: ADHESIVE, DENTURE, KARAYA (Medical Device)\tAbnormal bone structure (Abnormality of skeletal morphology)\taloe gel vera (Clinical Drug)\tLVI 9 (Cancer TNM Vessel Invasion Finding Category)\tSemi-solid dose form (Dosage Forms)", + "output": "LVI 9 (Cancer TNM Vessel Invasion Finding Category)" + }, + { + "input": "Definition: something described as excessive eyelid tissue laxity, typically affecting both upper eyelids and associated with spontanteous tarsal eversion during sleep. It is more common in the obese, it may be associated with obstructive sleep apnea and it may result in corneal exposure or chronic papillary conjunctivitis.\nConcepts: human T lymphotropic virus II (T-Cell Leukemia Viruses, Human)\tPhosphoprotein phosphohydrolase (Hydrolase)\tAPHTHOVIRUS (Foot-and-Mouth Disease Virus)\tIntraventricular route (Anatomy Qualifier)\tFloppy eyelid (Eyelid laxity)", + "output": "Floppy eyelid (Eyelid laxity)" + }, + { + "input": "Definition: Medical Device described as serology reagents intended to detect and/or identify antigens or serum antibody titers to hepatitis C virus, an RNA virus of the genus Flavivirus family Flaviviridae. Hepatitis C virus may cause hepatitis, a disease characterized by jaundice and the increase of some enzymes in serum (e.g., aspartate aminotransferase); this virus is transmitted frequently parenterally and possibly by intimate (e.g., sexual) contact.\nConcepts: IVD Test Reagent/Kits, Serology, Virus, Hepatitis C (IVD Test Reagent/Kits, Serology, Virus, Hepatitis)\tINGAPAB (Immunologic Tests)\tbromium/bromine (Pharmacologic Substance)\thelichrysum angustifolia (Oils, Volatile)\tRespiratory Therapist, Registered - Palliative/Hospice (Professional or Occupational Group)", + "output": "IVD Test Reagent/Kits, Serology, Virus, Hepatitis C (IVD Test Reagent/Kits, Serology, Virus, Hepatitis)" + }, + { + "input": "Definition: EEG with constitutional variants described as EEG with an amplitude less than 30 microvolts without observable occipital alpha rhythm (8-13 Hz).\nConcepts: EEGL (Finding)\tNumber of Prostate Cores Positive for Carcinoma (Finding)\tClinical Unit (Potency Unit)\tPoppyseed Oil (Food Oil)\tSWLS0102 (Intellectual Product)", + "output": "EEGL (Finding)" + }, + { + "input": "Definition: Merkel Cell Carcinoma Clinical TNM Finding v7 described as a clinical finding about one or more characteristics of Merkel cell carcinoma, following the rules of the TNM AJCC v7 classification system as they pertain to distant metastases.\nConcepts: FAC07536 (Intellectual Product)\tmastoids (Parameningeal structure in the context of malignancy)\tTransient neonatal glutaric acidaemia type 2 (Neonatal disorder)\tIsoforms, Protein (Proteins)\tMerkel Cell Carcinoma Clinical Distant Metastasis TNM Finding v7 (Merkel Cell Carcinoma Clinical TNM Finding v7)", + "output": "Merkel Cell Carcinoma Clinical Distant Metastasis TNM Finding v7 (Merkel Cell Carcinoma Clinical TNM Finding v7)" + }, + { + "input": "Definition: contractile actin filament bundle described as a contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber.\nConcepts: TAIL (Body Part, Organ, or Organ Component)\tcalcitriol binding (hormone binding)\tPHYSIS THICKNESS, DECREASED (Musculoskeletal System Finding)\tpositive regulation of interleukin-1-mediated signaling pathway (Molecular Function)\tstress fiber (Cell Component)", + "output": "stress fiber (Cell Component)" + }, + { + "input": "Definition: Receptor Gene described as this gene is involved in binding to class I MHC antigens.\nConcepts: Abnormal salivary gland morphology (Anatomical Abnormality)\tNatural Killer Cell Lymphoblastic Leukemia/Lymphoma (Precursor Lymphoid Neoplasm)\tTorulopsis rubra (Rhodotorula)\tneuroblast proliferation (Organ or Tissue Function)\tLEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR 1 (Gene or Genome)", + "output": "LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR 1 (Gene or Genome)" + }, + { + "input": "Definition: Disease or Syndrome described as transient cyanotic discoloration of the hands and feet, especially fingers and toes, in a newborn.\nConcepts: Pars parasympathica divisionis autonomici systematis nervosi (Neuroanatomy)\tinterleukin-18 secretion (Cell Function)\tNeonatal Acrocyanosis (Vascular Diseases)\tdownregulation of T cell homeostatic proliferation (negative regulation of T cell proliferation)\tIVD Test Reagent/Kits, Molecular Assay, RNA Expression, Cancer, Unknown Primary (Medical Device)", + "output": "Neonatal Acrocyanosis (Vascular Diseases)" + }, + { + "input": "Definition: Bacterium described as a species of anaerobic, Gram negative, rod shaped bacterium assigned to the phylum Proteobacteria. This species is motile, catalase positive, oxidase, urease and indole negative, produces hydrogen sulfide and is asaccharolytic. D. fairfieldensis is a commensal organism of the intestinal tract and is rarely seen to cause clinical disease.\nConcepts: Absent left hemidiaphragm (Respiratory Diaphragm)\ttreatment benefit (Benefit)\tMicroRNA Expression (Molecular Biology Research Technique)\tDesulfovibrio fairfieldensis (Desulfovibrio)\tresponse to external biotic stimulus (response to external stimulus)", + "output": "Desulfovibrio fairfieldensis (Desulfovibrio)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the execution phase of apoptosis and is involved in DNA repair.\nConcepts: Supplemental Qualifiers for Biospecimen Findings (Supplemental Qualifiers Tabulation Dataset)\tConnector Device (Device Component or Accessory)\tDigitizers, Document (Digitizers)\tDysphagia to Solids and Liquids (Finding)\tCPP32 (Gene or Genome)", + "output": "CPP32 (Gene or Genome)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.\nConcepts: Mitogen-Activated Protein Kinase Kinase Kinase 3 wt Allele (MAP3K3 gene)\tregulation of floral organ abscission (Organ or Tissue Function)\trndx tissue perfusion (Finding)\tresponse to gravity (Cell Function)\tSystem Motion, Unintended (Unintended Movement Medical Device Problem)", + "output": "response to gravity (Cell Function)" + }, + { + "input": "Definition: Immunologic Factor described as an antibody-drug conjugate (ADC) composed of an antibody against a structural homolog of the urokinase-type plasminogen activator receptor (uPAR) and tumor-associated antigen, C4.4a, and conjugated with a cytotoxic agent, with potential antineoplastic activity. Upon intravenous administration, lupartumab amadotin targets and binds to C4.4a-expressing tumor cells. Upon binding and cell entry, the cytotoxic agent kills the tumor cell. C4.4a, a glycolipid-anchored membrane protein and a member of the Ly-6 family, is overexpressed by a variety of cancer cell types whereas it is minimally expressed on healthy cells.\nConcepts: SPONDYLOMETAPHYSEAL DYSPLASIA, X-LINKED (Genetic Diseases, X-Linked)\tLUPARTUMAB AMADOTIN (Amino Acid, Peptide, or Protein)\tinactivation of paternal X chromosome (Genetic Function)\tbacillus pumilus (Bacterium)\tMicrococcus pyogenes (Mold singles)", + "output": "LUPARTUMAB AMADOTIN (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium ion stimulus.\nConcepts: Duboisinum / corkwood tree alkaloid (Homeopathic remedies letter D)\tresponse to ammonium ion (Cell Function)\tGated Protein Transport (Cell Function)\tPlanned Option Relationship (Relationships)\tEMO1TN (CDISC Functional Test Terminology)", + "output": "response to ammonium ion (Cell Function)" + }, + { + "input": "Definition: Abnormal CNS myelination described as leukodystrophy refers to deterioration of white matter of the brain resulting from degeneration of myelin sheaths in the CNS. Their basic defect is directly related to the synthesis and maintenance of myelin membranes.\nConcepts: Leukodystrophy NOS (Degenerative disorder)\tMedium Growth Rate (Property or Attribute)\tGrade 4 Neonatal Culture Positive Sepsis, AE (Finding)\tBiomedical equipment, device (Medical Devices)\tWD5-Days Unable to Carry Out Activities (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)", + "output": "Leukodystrophy NOS (Degenerative disorder)" + }, + { + "input": "Definition: Receptors, Drug described as receptors of CLONIDINE and other IMIDAZOLINES. Activity of the ligands was earlier attributed to ADRENERGIC ALPHA-2 RECEPTORS. Endogenous ligands include AGMATINE, imidazoleacetic acid ribotide, and harman.\nConcepts: canis streptococcus (Streptococcus)\tAntibacterial Agent [TC] (Anti-Bacterial Agents)\tImidazoline Receptor (Receptors, Drug)\tDentifrice associated slough (Disorder of oral mucous membrane)\tScalene Muscle (Lateral vertebral muscle of neck)", + "output": "Imidazoline Receptor (Receptors, Drug)" + }, + { + "input": "Definition: Organ or Tissue Function described as the process in which any suture between cranial and/or facial bones is generated and organized.\nConcepts: Hypoproconvertinemias (Hemorrhagic Disorders)\tcraniofacial suture morphogenesis (Organ or Tissue Function)\tArcuate vein of kidney (Body Part, Organ, or Organ Component)\tCarcinomas, Intraductal (Ductal carcinoma in situ - category)\tsuccinylornithine transaminase activity (aminotransferase activity)", + "output": "craniofacial suture morphogenesis (Organ or Tissue Function)" + }, + { + "input": "Definition: peripheral blood smear for RBC morphology described as an irreversible distortion of the morphology of an erythrocyte such that the cells are elongated and curved, resembling the blade of a sickle (the hand-held agricultural tool traditionally used to harvest grains). []\nConcepts: Textus muscularis striatus (Body part)\tEnkephalin convertase (Enzyme)\tAnterior segment ischemia (Disease or Syndrome)\tsickled erythrocytes (Poikilocytosis)\tCandida albicans skin test reagent (Indicator, Reagent, or Diagnostic Aid)", + "output": "sickled erythrocytes (Poikilocytosis)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: gamma-aminobutyric acid + 2-oxo monocarboxylic acid anion = 4-oxobutanoate + glycine.\nConcepts: Small bowel agenesis (Abnormality of the small intestine)\tgamma-aminobutyrate transaminase (glyoxylate dependent) activity (Molecular Function)\tContainer.capTypeCode (Code)\tmedicine chest (Equipment and Supplies)\tLATE INTRAUTERINE DEATH (Cessation of life)", + "output": "gamma-aminobutyrate transaminase (glyoxylate dependent) activity (Molecular Function)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as the combination of the lateral tuberal nuclei and the tuberomammillary nucleus, both of which are in the lateral hypothalamic area. They are found in the human ( Carpenter-1983 ) and the macaque ( Martin-2000 ). See also: tuberal nucleus.\nConcepts: SCALE, SPONGE, SURGICAL, ELECTRICALLY-POWERED (Medical Device)\tAdvanced Favorable Hodgkin Lymphoma (Neoplastic Process)\tIntensive Phase (Clinical Trial Epoch)\tSIQ-JR - I Thought About People Dying (Intellectual Product)\tNuclei tuberales (Body Part, Organ, or Organ Component)", + "output": "Nuclei tuberales (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Intellectual Product described as terminology used for representation of the information on pharmaceutical product contributing factors in the framework of the Structured Product Labeling documents.\nConcepts: SPL Contributing Factor-General Terminology (FDA Structured Product Labeling Terminology)\tTRH Gene Product (Amino Acid, Peptide, or Protein)\tDehydratase Inhibitor, Carbonate (ophthalmic preparation)\tIncreased bone density of end part of the 1st long bone of foot (Ivory epiphyses of the hallux)\tHas loud snoring (Sign or Symptom)", + "output": "SPL Contributing Factor-General Terminology (FDA Structured Product Labeling Terminology)" + }, + { + "input": "Definition: Gene or Genome described as human TOX wild-type allele is located in the vicinity of 8q12.1 and is approximately 314 kb in length. This allele, which encodes thymocyte selection-associated high mobility group box protein TOX, is involved in DNA binding and T-cell development.\nConcepts: Powder for dispersion for infusion (Biomedical or Dental Material)\tBiliary tract abnormality (Abnormality of the biliary system)\tRefrain from Smoking when Nervous (Intellectual Product)\tKIT Mutation Analysis Testing Method (Specify Mutation Analysis Method)\tTOX wt Allele (Gene or Genome)", + "output": "TOX wt Allele (Gene or Genome)" + }, + { + "input": "Definition: Biomedical or Dental Material described as liquid sterile preparation consisting of an aqueous solution of electrolytes typically at a concentration close to the intracellular electrolyte composition, intended for inducing cardiac arrest during heart surgery, and for storage, protection and/or perfusion of mammalian body organs that are in particular destined for transplantation.\nConcepts: Solution for Cardioplegia/Organ Preservation Dosage Form (Solution Dosage Form)\tCC5-targeting RNAi therapeutic ALN-CC5 (Pharmacologic Substance)\tSebaceous Gland Carcinoma of the Eyelid (Neoplastic Process)\tSeed Dispersal (Natural Phenomenon or Process)\tGrade 1 Dehydration (Finding)", + "output": "Solution for Cardioplegia/Organ Preservation Dosage Form (Solution Dosage Form)" + }, + { + "input": "Definition: something described as uterine corpus adenosarcoma without evidence of distant metastasis.\nConcepts: BPI - Miserable (BPI Questionnaire Question)\tUterine Corpus Adenosarcoma cM0 TNM Finding v8 (Finding)\tPharmacopoeias as Topic (Reference Books)\tanhydrotetracycline monooxygenase activity (Molecular Function)\tNeuropathy, hereditary motor and sensory, Okinawa type (Disease or Syndrome)", + "output": "Uterine Corpus Adenosarcoma cM0 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Geographic Area described as a country in Central Asia, west of China.\nConcepts: Kirghiz S.S.R. (USSR)\tSAHs (Central nervous system haemorrhages and cerebrovascular accidents)\tPDGFR-2 Exon 14 Mutation (PDGFRA Gene Mutation)\tdUMP synthesis (pyrimidine deoxyribonucleoside monophosphate biosynthetic process)\tGrade 4 Endophthalmitis (Endophthalmitis, CTCAE)", + "output": "Kirghiz S.S.R. (USSR)" + }, + { + "input": "Definition: Stereotactic Systems, Image-Guided described as image-guided computer-aided stereotactic surgical systems designed to aid in the performance of minimally invasive biopsy procedures by combining medical imaging, dedicated computer software, and surgical instrument tracking systems for guidance. The systems provide surgeons with real-time, three-dimensional (3-D) positioning and orientation of surgical instruments relative to the patient's anatomy on a video display during the biopsy without the use of an endoscope. Biopsy image-guided stereotactic systems provide medical images that show the location of the instruments in real time during the biopsy. One or more imaging modalities, such as computed tomography (CT) and/or magnetic resonance imaging (MRI), may be used in the procedure. Dedicated image-guided stereotactic systems intended for particular procedures such as breast, bronchi, and prostate biopsies are available.\nConcepts: supratrigeminal nucleus (Body Part, Organ, or Organ Component)\tAVL01-List A Recall 1 Word 6 (Intellectual Product)\tStereotactic Systems, Image-Guided, Biopsy (Medical Device)\tfracture; skull, base (Fracture of skull and facial bones)\tphosphoinositide-3-kinase, regulatory subunit 1 (Genes, Regulator)", + "output": "Stereotactic Systems, Image-Guided, Biopsy (Medical Device)" + }, + { + "input": "Definition: something described as increased size of the basal ganglia.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Staphylococcus Species (Medical Device)\tLarge basal ganglia (Central Nervous System)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, GBA (Medical Device)\textra-adrenal paraganglioma (Paraganglioma AND/OR glomus tumor)\tmaintenance of sister chromatin cohesion along arms at mitosis (Cell Function)", + "output": "Large basal ganglia (Central Nervous System)" + }, + { + "input": "Definition: Rhodobacteraceae described as gram-negative non-motile bacteria found in soil or brines.\nConcepts: Dynamic Orthoses (Medical Device)\tFP-R01-MG-F2 (Radioconjugate)\tLead Site V6 (Body Location or Region)\tParacoccus (Paracoccus bacteria)\tDistal duplication 6q (6q+ Syndrome, Partial)", + "output": "Paracoccus (Paracoccus bacteria)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether health care is less personal these days, but a small price to pay for medical advances.\nConcepts: Sensation seeking (Individual Behavior)\tPP (PPY gene)\tADCS-ADL Severe Dementia - Turn On Faucet to Wash Without Help (ADCS-ADL Severe Dementia Questionnaire Question)\tBLEO/5-FU/MTX/VCR (Therapeutic or Preventive Procedure)\tHealth Care is Less Personal but Pays for Medical Advances (Intellectual Product)", + "output": "Health Care is Less Personal but Pays for Medical Advances (Intellectual Product)" + }, + { + "input": "Definition: Antilipidemic Agent described as a highly purified omega-3 fatty acid that can decrease serum triglyceride levels. Icosapent ethyl reduces serum triglycerides without an increase in LDL cholesterol, but increases the cholesterol and triglyceride content in skeletal muscle.\nConcepts: (all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester (Pharmacologic Substance)\tCyclin B3 Gene (Gene or Genome)\tThrill (Finding by palpation)\torganelle outer membrane (Cell Component)\to-xylene degradation (xylene catabolic process)", + "output": "(all-Z)-5,8,11,14,17-Eicosapentaenoic acid ethyl ester (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as an indication or description that the conditions required by a specific protocol have been completed.\nConcepts: COND (Component of Study Protocol)\tDeformity of nose (Musculoskeletal and connective tissue deformities of skull, face and buccal cavity)\tDocetaxel-loaded Nanopharmaceutical CRLX301 (Taxane-Pocket Binding Agent)\toligopeptides binding involved in non-ribosomal peptide formation (Molecular Function)\tresponse to crowding (Physiologic Function)", + "output": "COND (Component of Study Protocol)" + }, + { + "input": "Definition: Tissue fluke described as a genus of trematode liver flukes of the family Dicrocoeliidae which includes the species dendriticum and hospes. It occurs in the biliary passages or liver of many vertebrates including man. The intermediate hosts are mainly mollusks but occasionally ants.\nConcepts: Dicrocoeliums (Dicrocoeliidae)\tDOUBLE CORTEX SYNDROME (Congenital disease of brain)\tMicrofluorometries, Flow (Laboratory procedure categorized by method)\tVINTAFOLIDE (Organic Chemical)\tetirinotecan pegol (Pharmacologic Substance)", + "output": "Dicrocoeliums (Dicrocoeliidae)" + }, + { + "input": "Definition: something described as a unique symbol that establishes identity of the donor registry. EXAMPLE(S): patient number 7 on a study OTHER NAME(S): NOTE(S):\nConcepts: Submucosa of organ (Organ component layer)\tDonor Registry Identifier (Identifier)\timmunoglobulins e (Amino Acid, Peptide, or Protein)\tClathrin Assembly Lymphoid Myeloid Leukemia Protein (Structural protein)\tblood vessel (Segment of blood vessel tree organ)", + "output": "Donor Registry Identifier (Identifier)" + }, + { + "input": "Definition: something described as a species of NAIROVIRUS, transmitted by the ixodid ticks and producing a lethal gastroenteritis in sheep and goats. Though a major veterinary pathogen, its effect on humans has not been firmly established.\nConcepts: v-akt Murine Thymoma Viral Oncogene Homolog 1 wt Allele (Gene or Genome)\tNairobi sheep disease virus (Virus)\tImportance 1 (Finding)\tMGC126766 (NSD3 gene)\tlinderae strychnifolia/wu ya (Oriental herbs and natural substances letter L)", + "output": "Nairobi sheep disease virus (Virus)" + }, + { + "input": "Definition: Organism Function described as any process that activates or increases the frequency, rate, or extent of interleukin-3 production.\nConcepts: MutY, E. COLI, HOMOLOG OF (Gene or Genome)\tBACILLUS ANTHRACIS (Bacillus species)\tAutomations, Office (Management Information Systems)\tupregulation of interleukin-3 production (positive regulation of cytokine production)\tbasal proximal dendrite (Cell Component)", + "output": "upregulation of interleukin-3 production (positive regulation of cytokine production)" + }, + { + "input": "Definition: something described as north Star Ambulatory Assessment (NSAA) Run as fast as you can to...(give point).\nConcepts: pentose transmembrane transport (monosaccharide transmembrane transport)\tMIR155 Pre-miRNA (pre-miRNA)\tNSAA1-Run (Intellectual Product)\tretrograde dendritic transport (dendritic transport)\tcurcumin-4'-O-beta-D-gentiobioside 1,6-glucosyltransferase activity (hexosyltransferase activity)", + "output": "NSAA1-Run (Intellectual Product)" + }, + { + "input": "Definition: Report described as a process that captures details such as additions, deletions, or alterations of information in an electronic record without obliterating the original record. An audit trail facilitates the reconstruction of the history of such actions relating to the electronic record.\nConcepts: antimicrobial humoral response (Humoral immune response)\tContact With Medical Risk Factor (Contagion Contact)\tAudit Trail (obligation policy)\tarabinose-5-phosphate isomerase activity (intramolecular oxidoreductase activity, interconverting aldoses and ketoses)\tASCVD1 (Clinical Classification)", + "output": "Audit Trail (obligation policy)" + }, + { + "input": "Definition: Spatial Concept described as physical location of INHBB_Gene\nConcepts: Cabinets, Storage, Desiccating (Manufactured Object)\t2: 120819229-120825204 (Spatial Concept)\tHot flushes menopausal (Sign or Symptom)\tEpendymoma NOS (Nervous system neoplasms unspecified malignancy NEC)\tpituitary hyperfunction (other endocrine disorders)", + "output": "2: 120819229-120825204 (Spatial Concept)" + }, + { + "input": "Definition: dermatological antifungal agents described as a triglyceride that is used as an antifungal agent.\nConcepts: FREE RADICAL ASSAY, COCAINE (Indicator, Reagent, or Diagnostic Aid)\tphenethyl isothiocyanate-containing watercress juice (Pharmacologic Substance)\tTriacetylglycerol (dermatological antifungal agents)\tMyosin III (Myosin ATPase)\tEarly onset sarcoidosis (Inflammatory dermatosis)", + "output": "Triacetylglycerol (dermatological antifungal agents)" + }, + { + "input": "Definition: Hydrocarbons, Chlorinated described as derivative of acetic acid which increases the activity of pyruvate dehydrogenase and rate of lipogenesis; it is used in organic synthesis, pharmaceuticals, and medicine.\nConcepts: Ethylchlorformate (Vaccine Adjuvant)\tDichloroacetate (acetate)\tMGC117328 (CST3 gene)\tperoxisome (Endoplasm)\tassisted death (Suicide)", + "output": "Dichloroacetate (acetate)" + }, + { + "input": "Definition: hearing impairment described as partial or complete loss of the ability to detect or understand sounds present in an infant within its first month after birth.\nConcepts: negative regulation of chondrocyte development (negative regulation of cell development)\tSF-36 v2.0 Acute - Question 9b (SF36 v2 0 Acute Questionnaire Question)\tHuman Rhinovirus B (Virus)\tNeonatal hearing loss (Hearing Loss)\tDextroamphetamine Saccharate (Amphetamines)", + "output": "Neonatal hearing loss (Hearing Loss)" + }, + { + "input": "Definition: Benign myoepithelioma described as a rare, well circumscribed, non-encapsulated tumor that arises in the oral cavity, most often the anterior tongue. It is characterized by the presence of round to spindle cells in a chondromyxoid or hyalinized stroma. Recurrences have been observed in a minority of patients.\nConcepts: ROS1 Rearrangement Analysis Was Not Performed (Testing Was Not Preformed)\tUDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity (UDP-galactosyltransferase activity)\tECT (Neoplastic Process)\tSOY PROTEIN (Amino Acid, Peptide, or Protein)\tEVERY AFTERNOON (Temporal Concept)", + "output": "ECT (Neoplastic Process)" + }, + { + "input": "Definition: Intellectual Product described as expanded Prostate Cancer Index Composite for Clinical Practice (EPIC-CP) Which of the following best describes your urinary control?\nConcepts: largetrifoliolious bugbane rhizome supplement (Dietary Supplements)\tWavy collarbone (Anatomical Abnormality)\tG-protein coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium levels (G protein-coupled neurotransmitter receptor activity)\tundef.bdy-mind prac narr req (Therapeutic or Preventive Procedure)\tEPIC202 (Intellectual Product)", + "output": "EPIC202 (Intellectual Product)" + }, + { + "input": "Definition: negative regulation of cell migration described as any process that stops, prevents, or reduces the frequency, rate or extent of myotube cell migration.\nConcepts: c-FMS (Gene or Genome)\tPerirenal fascia (Body Part, Organ, or Organ Component)\tHad a Little Difficulty When Trying to Think and Solve Day-to-day Problems (Clinical or Research Assessment Answer)\tTorsion of testis NOS (Testicular and epididymal disorders NEC)\tnegative regulation of myotube cell migration (negative regulation of cell migration)", + "output": "negative regulation of myotube cell migration (negative regulation of cell migration)" + }, + { + "input": "Definition: something described as the determination of the amount of 25-hydroxyvitamin D2 present in a sample.\nConcepts: Toll 4 Receptor (Amino Acid, Peptide, or Protein)\tV25HD2 (Vitamin D, 25-hydroxy measurement)\tCRR9p (Amino Acid, Peptide, or Protein)\tVibrio furnissii (Vibrio)\tNeurenteric Canal (Early differentiated embryonic structure)", + "output": "V25HD2 (Vitamin D, 25-hydroxy measurement)" + }, + { + "input": "Definition: something described as the older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking.\nConcepts: phagocytic cup base (Cell Component)\tMyelin-dependent gliosis (Gliosis)\thead kidney morphogenesis (Organ or Tissue Function)\tlanguage development (intellectual development)\tserum immunofixation electrophoresis (Laboratory Procedure)", + "output": "phagocytic cup base (Cell Component)" + }, + { + "input": "Definition: Education, Pharmacy described as educational programs designed to inform graduate pharmacists of recent advances in their particular field.\nConcepts: regulation of histone H2A-H2B dimer displacement (Cell Function)\tRed Meat Consumption (Individual Behavior)\tDisproportionately long ulnae (Abnormality of the ulna)\tPharmaceutical Education, Continuing (Educational Activity)\tpositive regulation of mitochondrial membrane permeability involved in programmed cell death (Cell Function)", + "output": "Pharmaceutical Education, Continuing (Educational Activity)" + }, + { + "input": "Definition: something described as catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase.\nConcepts: Allopathic & Osteopathic Physicians; Preventive Medicine, Addiction Medicine (Professional or Occupational Group)\tHeart Sound Auscultation at Left Lung Field (Heart Sounds)\t2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity (Molecular Function)\tCHIHERB (Antineoplastic Plant Product)\tLOWER EXTREMITY PAIN MUSCULOSKELETAL (SIGNS, SYMPTOMS AND MANEUVERS RELATED TO THE ENTIRE LOWER EXTREMITY)", + "output": "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo-citrate lyase activity (Molecular Function)" + }, + { + "input": "Definition: Nucleic Acid, Nucleoside, or Nucleotide described as MIR34B is an oligoribonucleotide that is encoded by the human MIR34B gene and has a role in the regulation of gene expression.\nConcepts: Lamin B1 wt Allele (Gene or Genome)\tGrade 2 Hypoalbuminemia (Finding)\tMIR34B Pre-miRNA (pre-miRNA)\tATR Kinase Inhibitor BAY1895344 (Pharmacologic Substance)\tBlood cell count, NOS (Blood cell analysis)", + "output": "MIR34B Pre-miRNA (pre-miRNA)" + }, + { + "input": "Definition: Intellectual Product described as an assessment of the Adaptive Behavior Assessment System where skills needed for successful functioning and holding a job in a work setting are evaluated.\nConcepts: Bone Staple Drivers (Surgical Instruments)\tPapio cynocephalus (Mammal)\tMitochondria in Apoptotic Signaling Pathway (Apoptosis Regulation Pathway)\tWork Skills (Intellectual Product)\tL-methionine synthesis from L-homoserine via cystathionine (Molecular Function)", + "output": "Work Skills (Intellectual Product)" + }, + { + "input": "Definition: Quantitative Concept described as ratio of radiation dosages required to produce identical change based on a formula comparing other types of radiation with that of gamma or roentgen rays.\nConcepts: Nasal Septum Surgery Scissors (Medical Device)\tAcute lymphoblastic leukaemia recurrent (Recurrent Acute Leukemia)\tFWSTRESN (Numeric Test Result)\tEffectiveness, Relative Biological (Radiation Dosage)\t2-amino-4-(S-butylsulfonimidoyl) butanoic acid (Amino Acid, Peptide, or Protein)", + "output": "Effectiveness, Relative Biological (Radiation Dosage)" + }, + { + "input": "Definition: GAIA Major Congenital Anomalies Level of Diagnostic Certainty described as level 4 Major Functional Defect is defined by two criteria: first, at least one of the following requirements must be met: a) For live births, there must be alterations in the functioning of one or more organs or body parts that are not due to a structural defect, that are present at the time of live birth (or propensity to develop alteration present at live birth), and that persist beyond the immediate peripartum period, unless treated through gene therapy or stem cell transplantation; OR b) For stillbirths or spontaneous or therapeutic abortions, there must be alterations in the function of one or more organs or body parts that are not due to a structural defect; second, at least one of the following requirements must be met: a) Documented confirmation in the medical record that the anomaly was present at the time of live birth or at the time of fetal demise, and that the anomaly was diagnosed by a trained maternal or child health care provider who is not a qualified geneticist, neonatologist, pathologist, subspecialist, paediatrician, obstetrician, or family medicine practitioner; OR b) Confirmation by claims data (ICD-9/ICD-10 diagnoses).\nConcepts: negative regulation of parathormone secretion (negative regulation of multicellular organismal process)\t2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase activity (Molecular Function)\tGAIA Level 4 Major Functional Defect (Intellectual Product)\tProduct containing elotuzumab (Monoclonal Antibody/Antibody-Drug Conjugate)\tKIAA1034 (Gene or Genome)", + "output": "GAIA Level 4 Major Functional Defect (Intellectual Product)" + }, + { + "input": "Definition: Genus Mycobacterium described as any bacterial organism that can be assigned to the species Mycobacterium intracellulare.\nConcepts: MSLOINC (Intellectual Product)\tMitogen-Activated Protein Kinase 13 (Amino Acid, Peptide, or Protein)\tAllogeneic Large Multivalent Immunogen Melanoma Vaccine LP2307 (Immunologic Factor)\tornithine biosynthetic process (Molecular Function)\tMYCOBACTERIUM INTRACELLULARE (Mycobacterium avium-intracellulare)", + "output": "MYCOBACTERIUM INTRACELLULARE (Mycobacterium avium-intracellulare)" + }, + { + "input": "Definition: Structure of inferior renal segment described as renal segment supplied by the inferior segmental branch of left renal artery.\nConcepts: Habenular trigone (Zone of diencephalon)\tUndesired Appetite Increase Score 0 (Undesired Appetite Increase Scale)\tFrequency of Loss of Control of Bowel Movements Past Seven Days (Clinical or Research Assessment Question)\tInferior vascular renal segment of left kidney (Parenchyma of left kidney)\tvegetative to reproductive phase transition of meristem (Organ or Tissue Function)", + "output": "Inferior vascular renal segment of left kidney (Parenchyma of left kidney)" + }, + { + "input": "Definition: Neoplastic Process described as ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, lungs (other than by direct extension from another site), or cerebrospinal fluid.\nConcepts: Current Medical Status (Intellectual Product)\tAnti-K-RAS G12D mTCR-transduced Autologous Peripheral Blood Lymphocytes (T-cell Receptor-engineered T-cells)\tHyponatremias (Disease or Syndrome)\tobsolete monounsaturated fatty acid biosynthetic process (Molecular Function)\tindolent stage IV adult non-Hodgkin's lymphoma (Neoplastic Process)", + "output": "indolent stage IV adult non-Hodgkin's lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Permanence described as not permanent; not lasting; lacking continuity or regularity.\nConcepts: temporary (Permanence)\tDiffusion Capacity of Lung for CO (Pulmonary function tests)\tcystadenoma of salivary gland (Cystadenoma)\tT Cytotoxic Cell Surface Molecules (Functional Concept)\tStilbamidines (Pharmacologic Substance)", + "output": "temporary (Permanence)" + }, + { + "input": "Definition: Chromosome 1 Physical Location described as physical location of EXTL2_Gene\nConcepts: Grade 2 Delayed orgasm (Delayed Orgasm, CTCAE)\t1: 101072389-101049965 (Chromosome 1 Physical Location)\ttype II activin receptor binding (Molecular Function)\tParamecium aurelias (Eukaryote)\tStage II Contiguous Adult Diffuse Mixed Cell Lymphoma (Neoplastic Process)", + "output": "1: 101072389-101049965 (Chromosome 1 Physical Location)" + }, + { + "input": "Definition: Paraprofessional Personnel described as unlicensed individual who may have training or certification and performs routine care activities for a patent in the home and may assist with activities of daily living.\nConcepts: sanguinaria canadensis/blood (Organic Chemical)\tCSS02-Ideation With Plan/Intent (C-SSRS Since Last Visit Questionnaire Question)\thome health aides (Supporting services personnel)\tpsi,psi-Carotene (L [Preparations])\tFACIAL (Head part)", + "output": "home health aides (Supporting services personnel)" + }, + { + "input": "Definition: Hematology described as an abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment.\nConcepts: FLT3 Inhibitor FF-10101 Succinate (Pharmacologic Substance)\tN-terminal protein amino acid acetylation (N-terminal protein amino acid modification)\taPTT prolonged (Hematology)\tToken economy (Therapeutic or Preventive Procedure)\tmental retardation-absent nails of hallux and pollex syndrome (Disease or Syndrome)", + "output": "aPTT prolonged (Hematology)" + }, + { + "input": "Definition: Medical Device described as vascular surgical clamps designed for the atraumatic compression of veins or arteries during microsurgical vascular procedures in infants/neonates, usually to cause total or partial occlusion (i.e., coarctation). These clamps are typically handheld, manual instruments including two parts pivoted at the center; dedicated microclamps of appropriate sizes and configurations are available for performing specific surgical procedures on infants.\nConcepts: TRH activity (Molecular Function)\tBioactive Enzymes-based Mouthwash (Pharmacologic Substance)\tpertussin/whooping cough nos (Pharmacologic Substance)\tClamps, Surgical, Vascular, Microsurgery, Infant (Clamps, Surgical, Vascular, Microsurgery)\tRectum fistula (Gastrointestinal Fistula, CTCAE 3.0)", + "output": "Clamps, Surgical, Vascular, Microsurgery, Infant (Clamps, Surgical, Vascular, Microsurgery)" + }, + { + "input": "Definition: Manufactured Object described as power systems designed for use as a source of electric and/or mechanical power to handpieces and/or other powered devices; the systems may also include ultrasonic and/or irrigation capabilities. These systems usually consist of a main unit that provides electrical and/or mechanical power using a motor to detachable handpieces (e.g., rotatory, oscillatory, reciprocating) that can drive dedicated instruments such as saws, burs, and blades, and a power switch (e.g., a hand or foot pedal). The systems also include a line cord and a cradle or rack for the handpieces. Electromechanical power systems may also include pumps used for irrigation, cooling, and/or other purposes and transducers to provide ultrasonic power; the systems are used in a variety of procedures (e.g., surgical, dental, otolaryngology).\nConcepts: Tunica media (Tissue)\tornithine decarboxylase (ODC) protein (Carboxy-Lyases)\t9: 131642479-131481711 (Chromosome 9 Physical Location)\tElectromechanical Power Systems (Power Systems)\tLunula (Integumentary system part)", + "output": "Electromechanical Power Systems (Power Systems)" + }, + { + "input": "Definition: psychopharmacologic agent described as a drug that calms and soothes, and reduces stress and tension. Tranquilizers are used to treat anxiety and insomnia.\nConcepts: Coumarin Compound (Organic Chemical)\tHypnotics and Sedatives (Central Nervous System Agents)\tHNF-1A (TRANSCRIPTION FACTOR)\tLeft atrioventricular junction (Body Space or Junction)\tAbnormal erythroid lineage cell morphology (Finding)", + "output": "Hypnotics and Sedatives (Central Nervous System Agents)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a subfamily of small heat-shock proteins found in a wide variety of organisms.\nConcepts: Lissauer marginal zone (Body Part, Organ, or Organ Component)\tSDTM-DRSTAT (CDISC SDTM Terminology)\tProbucolum (Substance with phenol structure)\tTumor of Meningothelial Cells (Neoplasm by Morphology)\tHSP30 Heat Shock Proteins (Amino Acid, Peptide, or Protein)", + "output": "HSP30 Heat Shock Proteins (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Colorectal Cancer Clinical Distant Metastasis TNM Finding v7 described as colorectal cancer with metastasis confined to one organ or site (e.g., liver, lung, ovary, nonregional node).\nConcepts: UAE inhibitor MLN7243 (Pharmacologic Substance)\tActive Pharmaceutical Ingredients Manufacturing (Manufacture)\tTT (Intellectual Product)\tTSC cpd (Vitamin)\tColorectal Cancer cM1a TNM Finding v7 (Finding)", + "output": "Colorectal Cancer cM1a TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Gel described as a combination of a dentifrice (formulation intended to clean and/or polish the teeth, and which may contain certain additional agents), and a gel. It is used with a toothbrush for the purpose of cleaning and polishing the teeth.\nConcepts: NK Cell-enriched Allogeneic Lymphocytes (Cell)\tDental gel (Gel)\tN-terminal peptidyl-methionine acetylation (N-terminal protein amino acid acetylation)\tTosoh Bioscience (Company)\tHuman Herpesvirus 5 Positive (Positive Laboratory Test Result)", + "output": "Dental gel (Gel)" + }, + { + "input": "Definition: Gene or Genome described as CC Cytokine Genes encode Beta Chemokines, CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils.\nConcepts: Abnormality of the thumbs (Abnormality of finger)\tUmbilical Cord Blood Stem Cell (Stem cells)\tCC Cytokine Gene (Cytokine Gene)\tDysplasias, Campomelic (Disorder of right lower extremity)\tSOLUTION, DECALCIFIER, ELECTROLYTIC (Indicator, Reagent, or Diagnostic Aid)", + "output": "CC Cytokine Gene (Cytokine Gene)" + }, + { + "input": "Definition: something described as the determination of the amount of Hepatitis E virus IgM antibody present in a sample.\nConcepts: CYST NOS (Mechanical lesion)\tPro-netupitant/Palonosetron (Antiemetics)\tnails (Integumentary system part)\tHEIGMAB (Laboratory Procedure)\tHM95573 (Organic Chemical)", + "output": "HEIGMAB (Laboratory Procedure)" + }, + { + "input": "Definition: Cell Function described as any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a laminar fluid shear stress stimulus. Laminar fluid flow is the force acting on an object in a system where the fluid is moving across a solid surface in parallel layers.\nConcepts: cellular response to laminar fluid shear stress (response to laminar fluid shear stress)\tureteric bud invasion (Organ or Tissue Function)\tInfection caused by Rickettsia felis (Disease or Syndrome)\texpectorate (Action)\tQLES154 (Intellectual Product)", + "output": "cellular response to laminar fluid shear stress (response to laminar fluid shear stress)" + }, + { + "input": "Definition: UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale 1999 Version (UHDRS 1999 Version) Saccade velocity, vertical.\nConcepts: OPCA, X-LINKED (Disease or Syndrome)\tUHDR103B (Intellectual Product)\tinterleukin-15 receptor binding (Molecular Function)\tNeoplasm of Peripheral Nervous System (Peripheral Nervous System Diseases)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria, Treponema Species (IVD Test Reagent/Kits, Molecular Assay, Infection, Bacteria)", + "output": "UHDR103B (Intellectual Product)" + }, + { + "input": "Definition: Driver/Extractors described as surgical driver/extractors designed to insert and extract bone plates into or from the surface of bones by applying linear force during orthopedic procedures. These instruments are typically manual, handheld devices with a working end that fits the plate (e.g., by threading to it) and a handle for manipulation. Bone plate driver/extractors are used mainly for temporary insertion of templates in orthopedic procedures (e.g., femur, knee prostheses implantation); dedicated instruments are available for particular plates used in specialized prostheses (e.g., patella templates).\nConcepts: Uptake Inhibitors, Adrenergic (Neurotransmitter Uptake Inhibitors)\tregulation of silent mating-type cassette heterochromatin assembly (Genetic Function)\tDriver/Extractors, Bone Plate (Driver/Extractors)\tChlorophycota (Green Plants)\tCap, Cervical (Medical Device)", + "output": "Driver/Extractors, Bone Plate (Driver/Extractors)" + }, + { + "input": "Definition: Common nursing interventions described as assessing a patient's excess fluid within his or her tissue.\nConcepts: Capnocytophaga gingivalis Leadbetter et al. 1982 emend. London et al. 1985 (CDC group DF-1)\tp-(N, N-Di-2-chloroethyl)aminophenyl butyric acid (Antineoplastic Agents)\tmicroRNA 155 (Gene or Genome)\tHeavy chain disease, IgG type (Heavy Chain Disease)\tEdema control assessment (Care regimes assessment)", + "output": "Edema control assessment (Care regimes assessment)" + }, + { + "input": "Definition: Impairment of Laryngeal Elevation described as a finding of no superior movement of thyroid cartilage during swallowing.\nConcepts: No Superior Movement of Thyroid Cartilage During Swallowing (Impairment of Laryngeal Elevation)\tGrade 2 Paroxysmal atrial tachycardia (Finding)\tSelf-Management: Anticoagulation Therapy (Finding)\tcuphea viscosissima/flux wee (Organic Chemical)\tLaser acupuncture (Acupuncture and allied techniques)", + "output": "No Superior Movement of Thyroid Cartilage During Swallowing (Impairment of Laryngeal Elevation)" + }, + { + "input": "Definition: Cell Growth described as the process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth.\nConcepts: WD5D2 2 (WHODAS 2.0 36-item Version Interviewer-administered Questionnaire Question)\tEMG: impaired neuromuscular transmission (Electromyogram abnormal)\tisotropic cell growth (Cell Function)\tpneumococcal, unspecified formulation (Bacterial Vaccines)\tLarge Unstained Cells to Leukocytes Ratio Measurement (Laboratory Procedure)", + "output": "isotropic cell growth (Cell Function)" + }, + { + "input": "Definition: Salvage Surgery described as a surgical technique that uses a specially designed robotic system to aid removal of pelvic lymph nodes after failure of initial surgery or other treatment modalities.\nConcepts: Grade 1 Edema face (Edema Face, CTCAE)\tHistidine (Amino acids measurement)\tciliary body morphogenesis (Organism Function)\tRobot-assisted Salvage Pelvic Lymph Node Dissection (Pelvic lymphadenectomy)\tlying (Spatial Concept)", + "output": "Robot-assisted Salvage Pelvic Lymph Node Dissection (Pelvic lymphadenectomy)" + }, + { + "input": "Definition: Disease or Syndrome described as a form of hereditary spastic paraplegia presenting with either a pure spastic paraplegia phenotype, usually in the first or second decade of life, with spastic lower extremities, unsteady spastic gait, hyperreflexia and extensor plantar responses, or as a complicated phenotype with the additional manifestations of distal wasting, saccadic ocular movements, mild cerebellar ataxia and mild, distal, axonal neuropathy.\nConcepts: Dose-dense Adriamycin/Cytoxan (Regimen Used to Treat Breast Carcinoma)\tBlasts Greater than or Equal to 10 Percent of Peripheral Blood White Cells (Blasts More Than 5 Percent of Peripheral Blood White Cells)\tElevated blood parathyroid hormone level (Endocrine System Diseases)\tAutosomal spastic paraplegia type 30 (Disease or Syndrome)\tCigarette Vapor, Electronic (Aerosol Dose Form)", + "output": "Autosomal spastic paraplegia type 30 (Disease or Syndrome)" + }, + { + "input": "Definition: Pelvic Cancer described as the spread of a malignant neoplasm from a primary site to the pelvic cavity.\nConcepts: Kallikreins, Tissue (Enzyme)\t15q22.33 (Chromosome band)\tRadiologic Imaging Procedure (Imaging Techniques)\tConclusion Not Yet Available (Device Evaluation Conclusion)\tMetastatic Malignant Neoplasm in the Pelvic Cavity (Secondary Neoplasm)", + "output": "Metastatic Malignant Neoplasm in the Pelvic Cavity (Secondary Neoplasm)" + }, + { + "input": "Definition: MUSCLE SOFT, TISSUE described as underdevelopment of the serratus anterior muscle, which is involved in abduction, upward Rotation, and elevation of the scapula.\nConcepts: Hypoplasia of serratus anterior muscle (Finding)\tSSD (Country)\tEGFR A289D (EGFR Protein Variant)\tRoots of brachial plexus (Brachial plexus structure)\tdiacetylchitobiose metabolic process (amino disaccharide metabolic process)", + "output": "Hypoplasia of serratus anterior muscle (Finding)" + }, + { + "input": "Definition: something described as human PTPRC wild-type allele is located in the vicinity of 1q31-q32 and is approximately 118 kb in length. This allele, which encodes receptor-type tyrosine-protein phosphatase C protein, plays a role in T-cell activation through the antigen receptor. Defects in the PTPRC gene are a cause of autosomal recessive severe combined immunodeficiency (SCID).\nConcepts: Assamese (Indo-Aryan Language)\tL-CA (Gene or Genome)\t3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea (Organic Chemical)\tVz Obs by F Norm by SA (Quantitative Concept)\tProstato- (Prostate part)", + "output": "L-CA (Gene or Genome)" + }, + { + "input": "Definition: Disease or Syndrome described as disorders caused by nutritional imbalance, either overnutrition or undernutrition, occurring in infants ages 1 month to 24 months.\nConcepts: Nutrition Disorder, Infant (Nutrition Disorders)\tInterstitial Pneumonia, Usual (Lung Diseases, Interstitial)\tproton transmembrane transporter activity (Molecular Function)\tWhile in the process of this bowel movement (Temporal Concept)\tregulation of chemokine secretion (regulation of cytokine secretion)", + "output": "Nutrition Disorder, Infant (Nutrition Disorders)" + }, + { + "input": "Definition: something described as this gene is involved in both signal transduction and apoptosis regulation.\nConcepts: quercetin-3,4'-O-glucosyltransferase activity (hexosyltransferase activity)\tTNF RECEPTOR-ASSOCIATED FACTOR 3 (Gene or Genome)\tEORTC Olsen Mycosis Fungoides And Sezary Syndrome 2011 Oncology Response Criteria (Intellectual Product)\tchildhood brain tumor, supratentorial ependymoma (Neoplastic Process)\tfacioacoustic ganglion development (Organ or Tissue Function)", + "output": "TNF RECEPTOR-ASSOCIATED FACTOR 3 (Gene or Genome)" + }, + { + "input": "Definition: something described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins.\nConcepts: response to somatocrinin (Cell Function)\tBartholin's Gland Adenoma (Benign neoplasm of Bartholin's gland)\tPosterior Wall of the Tympanum (Body Part, Organ, or Organ Component)\tRacks, Storage (Rack)\tConcatenation Character (UML Entity)", + "output": "response to somatocrinin (Cell Function)" + }, + { + "input": "Definition: Medical Device described as a syringe that lacks a conventional plunger, resembles a writing pen, and is designed to dispense a pre-loaded dose of a drug. It may be designed to deliver a single dose or be designed for repeated use.\nConcepts: Malformed tear ducts (Anatomical Abnormality)\tdrug serotonin (Pharmacologic Substance)\tL Antigen Family Member 1 (Amino Acid, Peptide, or Protein)\tDGR - Duodenogastric reflux (Finding of small intestine)\tPre-filled pen (Pre-filled Syringe)", + "output": "Pre-filled pen (Pre-filled Syringe)" + }, + { + "input": "Definition: pyridine nucleotide metabolic process described as the chemical reactions and pathways involving nicotinamide nucleotides, any nucleotide that contains combined nicotinamide.\nConcepts: histochemistry/cytochemistry (Histology)\talpha6-beta1 integrin complex location (Cell Component)\tnegative regulation of histidyl-aspartyl phosphorelay (regulation of phosphorelay signal transduction system)\tnicotinamide nucleotide metabolism (Molecular Function)\tIrregular end part of the middle bone of the pinkie finger (Irregular epiphyses of the 5th finger)", + "output": "nicotinamide nucleotide metabolism (Molecular Function)" + }, + { + "input": "Definition: Medical Device described as implants designed for plastic repair of a cardiac valve by restoring its anatomic shape and size, usually by shortening the circumference of its annulus. These implants typically consist of a rigid, semirigid, or flexible metal (e.g., titanium alloy) or synthetic (e.g., silicone elastomer, polyethylene) ring that is inserted around the natural annular structure of a cardiac valve; sometimes an incomplete ring, known as a \"C-ring,\" or band, is used. Dedicated annuloplasty ring and band implants are used to restore mitral (e.g., to prevent regurgitation) and/or tricuspid (e.g., to treat insufficiency) valves.\nConcepts: Annuloplasty Ring/Band Implants (Medical Device)\tMEK Inhibitor AZD8330 (Organic Chemical)\tregulation of female gametophyte central cell differentiation (regulation of multicellular organismal development)\tmillilitre/day (Unit of Dose Calculation)\tAMYLOSE (Organic Chemical)", + "output": "Annuloplasty Ring/Band Implants (Medical Device)" + }, + { + "input": "Definition: Cell Proliferation described as epithelial Cell Proliferation involves multiplication or reproduction through cell division of joined cells covering of internal and external surfaces of the body, including the lining of vessels and other small cavities.\nConcepts: ADL0122A (Intellectual Product)\tGUCA2A (Amino Acid, Peptide, or Protein)\tphotosystem II (Cell Component)\tEpithelial Cell Proliferation (cell population proliferation)\tmacula (Anatomical landmark)", + "output": "Epithelial Cell Proliferation (cell population proliferation)" + }, + { + "input": "Definition: something described as abnormally heavy or prolonged loss of blood.\nConcepts: excessive bleeding (hematologic symptoms)\tGastrointestinal Neuroendocrine Tumor Clinical TNM Finding v7 (Gastrointestinal Neuroendocrine Tumor TNM Finding v7)\tCSWBC (Urine Sediment Analysis Measurement)\tChemical/Occupational Exposure Type Unknown (Chemical/Occupational Exposure History)\tdystonic disorders (Dystonia Disorders)", + "output": "excessive bleeding (hematologic symptoms)" + }, + { + "input": "Definition: Colon Cancer by AJCC v7 Stage described as stage III includes: IIIA (T1-T2, N1/N1c, M0); (T1, N2a, M0); IIIB (T3-T4a, N1/N1c, M0); (T2-T3, N2a, M0); (T1-T2, N2b, M0); IIIC (T4a, N2a, M0); (T3-T4a, N2b, M0); (T4b, N1-N2, M0). T1: Tumor invades submucosa. T2: Tumor invades muscularis propria. T3: Tumor invades through the muscularis propria into pericolorectal tissues. T4a: Tumor penetrates to the surface of the visceral peritoneum. T4b: Tumor directly invades or is adherent to other organs or structures. N0: No regional lymph node metastasis. N1: Metastasis in 1-3 regional lymph nodes. N1c: Tumor deposit(s) in the subserosa, mesentery, or nonperitonealized pericolic or perirectal tissues without regional lymph node metastasis. N2: Metastasis in four or more regional lymph nodes. N2a: Metastasis in 4-6 regional lymph nodes. N2b: Metastasis in seven or more regional lymph nodes. M0: No distant metastasis.\nConcepts: response to ultraviolet radiation stimulus (response to light stimulus)\tFenfluraminum (Amphetamines)\tH2A Histone Family, Member Y Gene (MACROH2A1 gene)\tStage III Colon Cancer AJCC v7 (Neoplastic Process)\tAnti-OX40 Monoclonal Antibody INCAGN0194 (Immunologic Factor)", + "output": "Stage III Colon Cancer AJCC v7 (Neoplastic Process)" + }, + { + "input": "Definition: something described as a cervical squamous cell carcinoma with minimal stromal invasion. The risk of lymph node metastasis is low.\nConcepts: Microinvasive Cervical Squamous Cell Carcinoma (Neoplastic Process)\tConjunctival Melanoma Pathologic TNM Finding v8 (Finding)\tAnalyzers, Point-of-Care, Whole Blood, Hematology, Hemoglobin (Medical Device)\tRefractory Malignant Thyroid Gland Neoplasm (Refractory Malignant Head and Neck Neoplasm)\tInhibin (Glycoproteins)", + "output": "Microinvasive Cervical Squamous Cell Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Acute Erythroblastic Leukemia described as an acute erythroid leukemia occurring in children. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C9164\" active clinical trials using this agent.\nConcepts: chronic active (Functional Concept)\tAcute Erythroid Leukemia (Acute Erythroblastic Leukemia)\tAnalysis, Regression (Statistics as Topic)\tarachidonic acid binding (Molecular Function)\tCDISC Questionnaire GMSS Version Type 1 Diabetes Test Name Terminology (CDISC Questionnaire Terminology)", + "output": "Acute Erythroid Leukemia (Acute Erythroblastic Leukemia)" + }, + { + "input": "Definition: Sociology described as the business of attempting to influence or persuade individuals or the public to have an understanding or concern for, or positive disposition toward, a particular person, organization, idea, policy, practice, or activity.\nConcepts: leech therapy (Skin/Wound Management)\tRefractory Medulloblastoma (Refractory Malignant Brain Neoplasm)\tDissatisfaction with Appearance When Dressed (Findings-Based Question)\tVector Electrocardiography (Diagnostic Procedure)\tpublic relations (Career Areas)", + "output": "public relations (Career Areas)" + }, + { + "input": "Definition: Qualitative Concept described as supplying or being a probable or reasonable settlement or result.\nConcepts: Presumptive (Qualitative Concept)\tpositive regulation by symbiont of jasmonic acid levels in host (positive regulation by symbiont of hormone or growth regulator levels in host)\tCGI - Severity of Illness (CGI Questionnaire Question)\tphosphocreatine biosynthetic process (phosphocreatine metabolic process)\tNucleus pulvinaris medialis ventralis (Body Part, Organ, or Organ Component)", + "output": "Presumptive (Qualitative Concept)" + }, + { + "input": "Definition: Finding described as an abnormal decrease of the C-reactive protein level in serum.\nConcepts: Reduced C-reactive protein level (Finding)\tJV4-1 (Gene or Genome)\tIMPDH1 gene (Oxidoreductase Gene)\tKIAA1063 (Cysteine Protease Genes)\tInvestment, Dental Casting (Dental Materials)", + "output": "Reduced C-reactive protein level (Finding)" + }, + { + "input": "Definition: negative regulation of cellular carbohydrate metabolic process described as any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription.\nConcepts: Refractory Kidney Medullary Carcinoma (Renal medullary carcinoma)\tnegative regulation of cellular carbohydrate metabolic process by repression of transcription (negative regulation of transcription, DNA-templated)\tCalculus, mixed (Mixed calculus)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SNRPN (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tESRSA108 (ESRS-A Clinical Classification Question)", + "output": "negative regulation of cellular carbohydrate metabolic process by repression of transcription (negative regulation of transcription, DNA-templated)" + }, + { + "input": "Definition: negative regulation of pigment cell differentiation described as any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation.\nConcepts: down-regulation of iridophore differentiation (regulation of iridophore differentiation)\tacetaminophen, caffeine, paracetamol drug combination (acetaminophen / caffeine)\tmetestrus (Stage of estrous cycle)\tFGFR1 Gene Alteration (Laboratory or Test Result)\tVascular Calcifications (Disease or Syndrome)", + "output": "down-regulation of iridophore differentiation (regulation of iridophore differentiation)" + }, + { + "input": "Definition: something described as a protein encoded by the HLA-B gene.\nConcepts: 10q11-p12 (Cell Component)\t6: 24883143-24894257 (Chromosome 6 Physical Location)\tmaltose:phosphate 1-beta-D-glucosyltransferase activity (Molecular Function)\tHLA-B Gene Product (Histocompatibility Antigens Class I)\tTriangular shaped phalanges of the 2nd finger (Anatomical Abnormality)", + "output": "HLA-B Gene Product (Histocompatibility Antigens Class I)" + }, + { + "input": "Definition: Cell Function described as a protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells.\nConcepts: Agammaglobulinemia (Immunology)\tEcho Viruses (Virus)\tinheritance of oxidatively modified proteins involved in replicative cell aging (Cell Function)\tkm/h (Unit of linear velocity)\tNUP98-TOP1 Fusion Gene (Gene or Genome)", + "output": "inheritance of oxidatively modified proteins involved in replicative cell aging (Cell Function)" + }, + { + "input": "Definition: Measurement described as the act of measuring or estimating a quantity resulting from a laboratory test or analysis of the biological activity of a substance performed by studying its effect on an organism or in a test tube under controlled conditions.\nConcepts: hyposecretion; salivary gland (Salivary Gland Diseases)\tMedially deviated second toe (Deviation of the 2nd toe)\tBioassay Measurement (Laboratory Procedure)\tGender (Personal Attribute)\tNAIL CHANGES (Nail finding)", + "output": "Bioassay Measurement (Laboratory Procedure)" + }, + { + "input": "Definition: Disease or Syndrome described as an X-linked recessive condition caused by mutations(s) in the CUL4B gene on chromosome Xq23, encoding a core component of the E3 ubiquitin ligase complex. It is characterized by short stature, hypogonadism, and abnormal gait.\nConcepts: MRXS15 (x-linked intellectual disability)\tIL-1ra type II (interleukin-1 receptor antagonist activity)\tNM 000518.4:c.20A>T (Cell or Molecular Dysfunction)\tChest Pain Along Right Lower Sternal Border (Sign or Symptom)\tLaminin (Extracellular Matrix Proteins)", + "output": "MRXS15 (x-linked intellectual disability)" + }, + { + "input": "Definition: Hyperplasia described as intraluminal hyperplasia of endothelial cells, encircling the entire lumen.\nConcepts: Hepatitis B Virus Antigen Peptides/Hepatitis G2 Cell Protein Lysate-activated Dendritic Cells (Antineoplastic Immune Cell)\tCircumferential Endothelial Hyperplasia (Hyperplasia)\tcellular response to corticosterone stimulus (cellular response to ketone)\tPersistent Mullerian Duct Syndrome Type I (Persistent Mullerian duct syndrome)\tAcute Synovitis (Disease or Syndrome)", + "output": "Circumferential Endothelial Hyperplasia (Hyperplasia)" + }, + { + "input": "Definition: Protein Binding Motif described as a consensus tripeptide that is recognized by and for binding to proteins of the integrin family, including many cell adhesion molecules. The one-letter codes for arginine - glycine - aspartic acid. This motif can be found in proteins of the extracellular matrix and it is recognized by different members of the integrin family. The structure of the tenth type III module of fibronectin has shown that the RGD motif lies on a flexible loop.\nConcepts: PODCI317 (PODCI Adolescent Self-Reported Version Questionnaire Question)\tRGD Peptide (Biologically Active Substance)\tCytidylic acid (Cytosine Nucleotides)\tAble with difficulty (Finding)\tCoumarin, 7-Hydroxy-6-Methoxy- (Biologically Active Substance)", + "output": "RGD Peptide (Biologically Active Substance)" + }, + { + "input": "Definition: Intellectual Product described as a response indicating that it is or was almost impossible for an individual to get a decent night's sleep.\nConcepts: It is almost impossible for me to get a decent night's sleep (Clinical or Research Assessment Answer)\tGlottic Cancer cM0 TNM Finding v7 (Finding)\tHLA Class I Histocompatibility Antigen, Cw-1 Alpha Chain Protein (Amino Acid, Peptide, or Protein)\tsyringetin 7-O-methyltransferase activity (Molecular Function)\tInfantile apnea (Neonatal Adverse Event)", + "output": "It is almost impossible for me to get a decent night's sleep (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Dental impression material described as a mixture of several dental waxes, usually containing paraffin wax, ceresin, beeswax, resins, and other natural and synthetic waxes. It is used for making patterns to determine the shape of the metallic framework and other parts of removable partial dentures.\nConcepts: RCPCTAUB (Percent Recovered Over Dosing Interval)\tsense organ boundary specification (Organism Function)\tPharmacokinetic Concentration Subcategory (Classification)\tARTISTIC ANAT (Medical Illustration)\tCasting Wax, Inlay (Biomedical or Dental Material)", + "output": "Casting Wax, Inlay (Biomedical or Dental Material)" + }, + { + "input": "Definition: MYO ENDO PERICARDIAL & VALVE DISORDERS described as blood flows backward because the mitral valve closes improperly\nConcepts: Oversensing cardiac pacemaker (Cardiac pacemaker sensitivity problem)\tHYPERTHYROIDISM (Thyroid Diseases)\tValve Regurgitation, Mitral (Pathologic Function)\tDIBD (Temporal Concept)\t8th (Disease Stage Qualifier)", + "output": "Valve Regurgitation, Mitral (Pathologic Function)" + }, + { + "input": "Definition: Sense of identity finding described as imbalance in the ability to distinguish between the self and the non-self\nConcepts: Character Set (Intellectual Product)\tMammalian Orthoreovirus (Virus)\tAngioma serpentinum (Congenital Abnormality)\tPersonal identity disturbance (Sense of identity finding)\tSuprarenal medulla (Layer of adrenal gland)", + "output": "Personal identity disturbance (Sense of identity finding)" + }, + { + "input": "Definition: something described as liquid, usually multidose preparation consisting of an emulsion intended for inhalation use. The preparation is presented in a pressurized container fitted with a metering dose valve.\nConcepts: Kidney Scarring (Kidney)\tUntreated Gliomatosis Cerebri (Neoplastic Process)\tUterine Corpus Carcinoma pT1a TNM Finding v7 (Finding)\tPressurized emulsion for inhalation (Pulmonary dose form)\tSurgical Procedure, Arthroscopic (Arthroscopy)", + "output": "Pressurized emulsion for inhalation (Pulmonary dose form)" + }, + { + "input": "Definition: Medical Device described as microbiology reagents intended to identify Aeromonas, a genus of bacteria of the family Vibrionaceae, by detecting the target bacteria, usually through tests performed on bacteria cultures. Some species of these bacteria may infect humans, causing furunculosis or ulcer disease.\nConcepts: hPAK3 (Serine/Threonine Protein Kinase Gene)\tselective IgA deficiency (Humoral immune defect)\twms-iv subtests designs i (Intellectual Product)\tFinding of condition of completely dentate teeth (Finding of dentition)\tIVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Aeromonas Species (Medical Device)", + "output": "IVD Test Reagent/Kits, Microbiology, Bacteria, Identification, Aeromonas Species (Medical Device)" + }, + { + "input": "Definition: Molecular Function described as interacting selectively and non-covalently with a CRD (context dependent regulatory) domain, a domain of about 130 residues that is the most divergent region among the LEF/TCF proteins.\nConcepts: regulation of ER stress response (Cell Function)\tcontext dependent regulatory domain binding (protein domain specific binding)\tMISTRESC (Finding)\tAdjuvant Post-operative Chemotherapy Was Administered (CPTAC Responses)\tMountaineering (Outdoor pursuit)", + "output": "context dependent regulatory domain binding (protein domain specific binding)" + }, + { + "input": "Definition: Finding described as an indication that the patient was unwell at the time the chief complaint was manifested.\nConcepts: X-linked intellectual disability, nail dystrophy, seizures syndrome (Multiple malformation syndrome with facial defects as major feature)\tMounts, Monitor (Manufactured Object)\tIntercurrent Illness is Present at Onset of Chief Complaint (Other Finding)\tChemoradiotherapy (Therapeutic radiology procedure)\tBlast to Leukocyte Ratio Measurement (Blood Cell Count Ratio Measurement)", + "output": "Intercurrent Illness is Present at Onset of Chief Complaint (Other Finding)" + }, + { + "input": "Definition: Flavoproteins described as low molecular weight iron-free flavoprotein containing one molecule of flavin mononucleotide and isolated from bacteria grown on an iron-deficient medium; can replace ferredoxin in all the electron-transfer functions in which the latter is known to serve in bacterial cells.\nConcepts: flavodoxin (Proteins)\tmovement involuntary (motor exam)\tEOR01-Have You Vomited (Intellectual Product)\tRREB1 Gene (Gene or Genome)\tTremor by anatomical site (Tremor)", + "output": "flavodoxin (Proteins)" + }, + { + "input": "Definition: something described as human CYP2C8*6 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*6 protein. The CYP2C8*6 allele exhibits a SNP (c.511G>A) in exon 4 that results in a G171S coding change. However, this alteration in protein sequence has no effect on the enzymatic activity of the cytochrome P450 2C8*6 protein.\nConcepts: Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*6 Allele (Gene or Genome)\tleaf morphogenesis (plant organ morphogenesis)\tStage II Hepatocellular Carcinoma AJCC v6 (Hepatocellular Carcinoma by AJCC v6 Stage)\tRectal gel (Biomedical or Dental Material)\tAbsence of intermediate von Willibrand factor multimers (Finding)", + "output": "Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*6 Allele (Gene or Genome)" + }, + { + "input": "Definition: something described as the process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function.\nConcepts: forebrain astrocyte development (astrocyte development)\tTumor Necrosis Factor Decoy Receptors (Biologically Active Substance)\t1q21.1 microduplication syndrome (Disease or Syndrome)\tIron Staining Method (Laboratory Procedure)\tpositive regulation of alkaline phosphatase activity (positive regulation of phosphatase activity)", + "output": "forebrain astrocyte development (astrocyte development)" + }, + { + "input": "Definition: Experimental Organism Finding described as a single giant cell that is created from the fusion of mononuclear cells, or a network of cells that serve a particular purpose.\nConcepts: Iron Urine Excretion Rate (Excretion Rate)\tSyncytia (Finding)\tClosure atrial septal defect (Heart - Septum: Repair)\tGrade 2 Bronchopulmonary Dysplasia, Adverse Event (Finding)\tLocalized Bone Ewing's Sarcoma (Localized Ewing Sarcoma)", + "output": "Syncytia (Finding)" + }, + { + "input": "Definition: Parenteral feeding management described as change in time(s) of day for delivery of parenteral (PN) formula\nConcepts: AMPUTATION THRU METATARSAL (Amputation of lower limb)\tmitotic spindle midzone formation (spindle midzone assembly)\tpn mgmt/cntrl ea.addtl 15min (Therapeutic or Preventive Procedure)\tManagement of schedule of parenteral nutrition (Parenteral feeding management)\tGrade 1 Scoliosis, CTCAE (Finding)", + "output": "Management of schedule of parenteral nutrition (Parenteral feeding management)" + }, + { + "input": "Definition: Obstetric Delivery described as delivery of an infant through the vagina in a female who has had a prior cesarean section.\nConcepts: somatotype (Organism Attribute)\tIn situ hybridization (Molecular Biology Research Technique)\tSYSTEM, RADIATION THERAPY, RADIONUCLIDE (Medical Device)\t1: 67485068-67574604 (Spatial Concept)\tVaginal Birth after Caesarean (Vaginal delivery procedure)", + "output": "Vaginal Birth after Caesarean (Vaginal delivery procedure)" + }, + { + "input": "Definition: something described as a cone-shaped appearance of the epiphyses of the thumb, producing a 'ball-in-a-socket' appearance. The related entity 'angel-shaped' epiphysis refers to a pronounced cone-shaped epiphysis in combination with a pseudoepiphysis at the distal end of a phalanx.\nConcepts: Cone-shaped epiphyses of the thumb (Abnormality of thumb epiphysis)\tInsertion Difficulties (Finding)\tCTTN (Structural gene)\tBenign neoplasm of bone of skull, NOS (Benign tumor of head and neck)\tNickel compound (Nickel and nickel compound)", + "output": "Cone-shaped epiphyses of the thumb (Abnormality of thumb epiphysis)" + }, + { + "input": "Definition: Clinical or Research Assessment Questionnaire described as a standardized rating scale developed by Juniper et al in 1999, which is used to assess both the adequacy of and change in asthma control. This questionnaire contains 7 items using a 7-point scale.\nConcepts: Double-Unit Umbilical Cord Blood Transplantation (Therapeutic or Preventive Procedure)\ttrans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity (Molecular Function)\tPUL02-Flexion Shoulder Height No Weights (Intellectual Product)\tACQ (Intellectual Product)\tEuglena gracilis bacillaris (Eukaryote)", + "output": "ACQ (Intellectual Product)" + }, + { + "input": "Definition: something described as engaging in organized religious ceremonies, activities and events.\nConcepts: Organized religion (Religion and Spirituality)\tProduct containing beta-2 adrenergic receptor antagonist (Adrenergic beta-Antagonists)\tMy mind is as sharp as it has always been (Clinical or Research Assessment Question)\tphospholipase C-activating G protein-coupled glutamate receptor signaling pathway (Molecular Function)\tEpicardium of right atrium (Body Part, Organ, or Organ Component)", + "output": "Organized religion (Religion and Spirituality)" + }, + { + "input": "Definition: Oral cavity described as posterior displacement of the TONGUE toward the PHARYNX. It is often a feature in syndromes such as in PIERRE ROBIN SYNDROME and DOWN SYNDROME and associated with AIRWAY OBSTRUCTION during sleep (OBSTRUCTIVE SLEEP APNEAS).\nConcepts: FACT-HEP Version 4 - I Can Digest My Food Well (FACT-HEP Version 4 Questionnaire Question)\tSentrin/SUMO-Specific Protease SENP6 (Enzyme)\tglossoptosis (Disease or Syndrome)\tPrimary Irritant Dermatitides (Dermatitis, Irritant)\tcellular glucose metabolic process (Carbohydrate Metabolism)", + "output": "glossoptosis (Disease or Syndrome)" + }, + { + "input": "Definition: Chemical procedure described as a measurement of the glucagon hormone in a biological specimen.\nConcepts: Aromatic L-Amino Acid Decarboxylase (Enzyme)\tHumero-scapulo synostosis (Synostosis involving bones of the upper limbs)\tFeer disease (Injury or Poisoning)\tGlucagon Measurement (Chemical procedure)\tregulation of serotonin biosynthesis (regulation of cellular biosynthetic process)", + "output": "Glucagon Measurement (Chemical procedure)" + }, + { + "input": "Definition: Cooking Practices described as cooking of meats over an open flame. A cooking practice associated with increased risk of breast cancer.\nConcepts: Flame-Broiling (Human-caused Phenomenon or Process)\tpositive regulation of granuloma formation (regulation of granuloma formation)\tDose Denominator Individual Case Safety Report Terminology (Intellectual Product)\thousework (Occupational Activity)\tMDS-UPDRS - Posture (MDS-UPDRS Questionnaire Question)", + "output": "Flame-Broiling (Human-caused Phenomenon or Process)" + }, + { + "input": "Definition: Character Result or Finding in Standard Format described as the standard character or string for representation and reporting of disease response data.\nConcepts: 1,2-dihydrovomilenine reductase activity (oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor)\tHypoplastic areola (Abnormal areolar morphology)\tFocal cortical dysplasia type Ic (Focal cortical dysplasia type Ib)\tRSSTRESC (Quantitative Concept)\tNon-Steroidal Estrogen Synthase Inhibitor (Pharmacologic Substance)", + "output": "RSSTRESC (Quantitative Concept)" + }, + { + "input": "Definition: Neoplastic Process described as stage IV: Disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ) Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C8485\" active clinical trials using this agent.\nConcepts: heparan sulfate proteoglycan catabolism (heparan sulfate proteoglycan metabolic process)\tN-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide (Cyclin-Dependent Kinase Inhibitor Agents)\tGonadal Agenesis (Non-Neoplastic Endocrine Disorder)\tAnn Arbor Stage IV Indolent Adult Non-Hodgkin Lymphoma (Neoplastic Process)\tprefrontal lobe (Body Part, Organ, or Organ Component)", + "output": "Ann Arbor Stage IV Indolent Adult Non-Hodgkin Lymphoma (Neoplastic Process)" + }, + { + "input": "Definition: Tracheophyta described as a genus of slow-growing perennial plants with fleshy roots of the family Araliaceae native to the Northern Hemisphere.\nConcepts: Stents, Eye, Glaucoma Drainage (Medical Device)\t5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)- (Antibiotic)\tPain in stomach or abdomen (Sign or Symptom)\ttarget population (Population Group)\tRenshens (Plant)", + "output": "Renshens (Plant)" + }, + { + "input": "Definition: something described as catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative.\nConcepts: Metastatic Thymic Neuroendocrine Neoplasm (Neoplastic Process)\tBenign Paranasal Sinus Tumor (Paranasal Sinus Neoplasms)\tautologous human OC-IgT cells (Cell)\tglucosidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)\tFractional Flow Reserve (Clinical Attribute)", + "output": "glucosidase activity (hydrolase activity, hydrolyzing O-glycosyl compounds)" + }, + { + "input": "Definition: Disease or Syndrome described as transient hypoglycemia that occurs in the infant of a diabetic mother due to increased postnatal insulin release as a result of in utero exposure to maternal hyperglycemia.\nConcepts: Betacoccus (BACTERIA AND RICKETTSIAE)\tplannedInvestigationalExposureQuotient (Quotient)\tHyperinsulinism in the Infant of a Diabetic Mother (Disease or Syndrome)\tTrigeminal Nucleus, Spinal (somatosensory system)\tHEP (Gene or Genome)", + "output": "Hyperinsulinism in the Infant of a Diabetic Mother (Disease or Syndrome)" + }, + { + "input": "Definition: Organic Chemical described as an agent targeting the phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. Upon intravenous administration, gedatolisib inhibits both PI3K and mTOR kinases, which may result in apoptosis and growth inhibition of cancer cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy; mTOR, a serine/threonine kinase downstream of PI3K, may also be activated independent of PI3K. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C91732\" active clinical trials using this agent.\nConcepts: Orthoses, Upper Limb, Wrist-Hand, Functional, Ratchet Mechanism (Orthoses, Upper Limb, Wrist-Hand, Functional)\tCancer screening (patient screening)\tup regulation of immune response (positive regulation of immune system process)\tGEDATOLISIB (Pharmacologic Substance)\tMicroalbumin 1+ (Finding)", + "output": "GEDATOLISIB (Pharmacologic Substance)" + }, + { + "input": "Definition: Medical Device described as atherectomy angioplasty catheters that cut or shave atheroma and directly remove the excised material from the vessel using a collection chamber or suction port. These catheters typically consist either of a semiflexible catheter which includes a cup-shaped cutter that slices atheroma at the center of a nonflexible housing, and an opposing dilated balloon that forces the plaque through a window into the metal housing during each cut (directional atherectomy); or of a semiflexible, torque-controlled, hollow catheter that includes an introducer sheath over a central guide wire for proper alignment with the atherosclerotic lesion, a rotating cone-shaped cutter in a housing unit to shave the plaque, and a collecting vacuum bottle situated at the proximal end of the catheter (transluminal extraction catheters). Extirpative atherectomy catheters are mostly used for treating short, discrete, eccentrically placed atheroma, including calcific eccentric stenoses not normally amenable to balloon dilatation.\nConcepts: Real-Time Polymerase Chain Reaction (Molecular Biology Research Technique)\tregulation of neuron apoptosis (regulation of neuron death)\tZimmermannella bifida (Bacterium)\tPsychotic disorder caused by substance (Schizophrenia and other psychotic disorders)\tCatheters, Vascular, Angioplasty, Atherectomy, Extirpative (Catheters, Vascular, Angioplasty, Atherectomy)", + "output": "Catheters, Vascular, Angioplasty, Atherectomy, Extirpative (Catheters, Vascular, Angioplasty, Atherectomy)" + }, + { + "input": "Definition: Immunologic Factor described as carcinoembryonic antigen-related cell adhesion molecule 1 (526 aa, ~58 kDa) is encoded by the human CEACAM1 gene. This protein is involved in differentiation, angiogenesis, apoptosis, immune response, and tumorigenesis.\nConcepts: RAL Guanine Nucleotide Dissociation Stimulator Gene (Signaling Pathway Gene)\tDesign, construction and building products and technology for entering and exiting of buildings for private use (Design, construction and building products and technology of buildings for private use)\tCEACAM1 (Immunologic Factor)\tLEC01-Assault With a Weapon: Not Sure (Intellectual Product)\tarea Iam of Carmichael (area 10 of Walker)", + "output": "CEACAM1 (Immunologic Factor)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in transcriptional regulation.\nConcepts: prostanoid metabolic process (eicosanoid metabolism)\tGTF3C3 Gene (Gene or Genome)\tColesevelam Hydrochloride (Pharmacologic Substance)\tmidwifery (Discipline of obstetrics)\tup regulation of red blood cell apoptotic process (Cell Function)", + "output": "GTF3C3 Gene (Gene or Genome)" + }, + { + "input": "Definition: Population Group described as a person having origins in any of the original peoples of Trinidad.\nConcepts: \"Speech, Language and Hearing Service Providers\"; Audiologist (Health Personnel)\tTRINIDADIAN (Black Caribbean)\tRSRPENUM (Numbers)\tVolume of Distribution for Dosing Interval by Fraction (Quantitative Concept)\tStomach atony (gastric and duodenal disorders)", + "output": "TRINIDADIAN (Black Caribbean)" + }, + { + "input": "Definition: something described as catalysis of the reaction: (S)-naringenin(1-) + S-adenosyl-L-methionine <=> sakuranetin + S-adenosyl-L-homocysteine + H+.\nConcepts: naringenin 7-O-methyltransferase activity (methyltransferase activity)\tMONTMKNM (Intellectual Product)\tResults Knowledge (Statistical Theory & Experimentation)\tANALYZER, CHEMISTRY (PHOTOMETRIC, DISCRETE), FOR CLINICAL USE (Medical Device)\tMetaplasia, NOS (abnormal growth and differentiation)", + "output": "naringenin 7-O-methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: Biologically Active Substance described as histone H2A type 1-H (128 aa, ~14 kDa) is encoded by the human H2AC12 gene. This protein is involved in nucleosome assembly.\nConcepts: Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma (Neoplastic Process)\t258 TISSIERELLA (Anaerobic Gram-negative bacillus)\tAlpha4/Beta1 (Amino Acid, Peptide, or Protein)\tIONM (Health Care Activity)\tHIST1H2AH (Biologically Active Substance)", + "output": "HIST1H2AH (Biologically Active Substance)" + }, + { + "input": "Definition: trisaccharide transport described as the directed movement of a xylotrioseacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: MAGE-A1, MAGE-A3, NY-ESO-1 peptides vaccine (Vaccines, Peptide)\txylotriose transport (Cell Function)\tiberdomide (Biological Response Modifiers)\tlimonene 3-hydroxylase activity (Molecular Function)\tMalignancies (Classification)", + "output": "xylotriose transport (Cell Function)" + }, + { + "input": "Definition: Indicator, Reagent, or Diagnostic Aid described as a lipid peroxidation disease marker detected in the serum, biological fluids, and cell cultures using ELISA immunoassay kits. It is increased in patients with non-insulin dependent diabetes mellitus, coronary heart disease, and hypertension.\nConcepts: 8-iso Prostaglandin F2alpha (Isoprostanes)\tAdenocarcinoma of the Gallbladder (Gallbladder Carcinoma)\tMED RECORDS (HL7PublishingDomain)\tChristian Science support in-office 40 minutes (Christian Science care)\tkeratin filament binding (intermediate filament binding)", + "output": "8-iso Prostaglandin F2alpha (Isoprostanes)" + }, + { + "input": "Definition: Organism Function described as the process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate.\nConcepts: substrate mycelium formation (anatomical structure development)\tOvarian Dermoid Cyst with Melanocytic Nevus (Neoplastic Process)\tregulation of p97-Ufd1-Npl4 complex assembly (Cell Function)\tprogesterone metabolism (Molecular Function)\tGrade 4 HIE, AE (Hypoxic Ischemic Encephalopathy, Adverse Event)", + "output": "substrate mycelium formation (anatomical structure development)" + }, + { + "input": "Definition: Disorder of soft tissue of upper limb described as the term rotator cuff describes the tendons connecting the infraspinatus, supraspinatus, teres minor, and subscapularis muscles to the humeral head.Traumatic tears of the rotator cuff tend to occur at the tendon-bone junction of the supraspinatus and greater tuberosity of the humerus whereas degenerative tears tend to be seen posteriorly at the junction of the supraspinatus and infraspinatu A rotator cuff tear is when one or more of these tendons tears or detaches from the humerus.\nConcepts: electron carrier, chlorophyll electron transport system (Molecular Function)\tregulation of behavioral fear response (regulation of fear response)\tROTATOR CUFF RUPTURE (Arthropathy)\tCYP2C8, c.792C>G (Gene or Genome)\tBfa1-Bub2 complex location (GTPase activator complex)", + "output": "ROTATOR CUFF RUPTURE (Arthropathy)" + }, + { + "input": "Definition: Antiviral Agents described as an alkoxyalkyl ester prodrug containing the synthetic, acyclic nucleoside monophosphate analog cidofovir linked, through its phosphonate group, to a lipid, 3-hexadecyloxy-1-propanol, with antiviral activity against double-stranded DNA viruses. Upon oral administration, brincidofovir crosses the intestinal wall and penetrates target viral-infected cells before being cleaved to the free antiviral agent cidofovir. In turn, cidofovir is phosphorylated by pyruvate kinases to its active metabolite cidofovir diphosphate. Cidofovir diphosphate, bearing structural similarity to nucleotides, competes with deoxycytosine-5-triphosphate (dCTP) for viral DNA polymerase and gets incorporated into the growing viral DNA strands. As a result, it prevents further DNA polymerization and disrupts DNA replication of viruses. Compared to cidofovir, which is given intravenously, hexadecyloxypropyl-cidofovir shows better oral bioavailability, less toxicity and enhanced cellular penetration. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C90587\" active clinical trials using this agent.\nConcepts: Narrow column of contrast or air between TB and PW (Finding)\tLysine (K)-Specific Demethylase 1A wt Allele (KDM1A gene)\tInfluenza Type A (Influenzavirus A)\tNo risk (Finding)\tcidofovir hexadecyloxypropyl ester (Antiviral Agents)", + "output": "cidofovir hexadecyloxypropyl ester (Antiviral Agents)" + }, + { + "input": "Definition: something described as test names of clinical classification questions associated with the West Haven Hepatic Encephalopathy Grade (West Haven Criteria) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Negative-Pressure Respirator (Ventilator - respiratory equipment)\tIntracranial Extension (Pathologic Function)\tCC-West Haven Criteria TEST (CDISC Clinical Classification Terminology)\tCGI - Severity of Illness (Intellectual Product)\tCapsule of kidney (Zone of dense endoabdominal fascia)", + "output": "CC-West Haven Criteria TEST (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Neoplastic Process described as a meningioma that affects the ventricles of the brain.\nConcepts: Polygala (Plant)\trecurrent childhood grade III angiocentric immunoproliferative lesions (Recurrent Grade III Lymphomatoid Granulomatosis)\tMeningioma, Intraventricular (Intracranial Meningioma)\tp-hydroxybenzoic acid-polyprenyl transferase activity (polyprenyltransferase activity)\tSuspension Dosage Form Category (Basic Dosage Form Category)", + "output": "Meningioma, Intraventricular (Intracranial Meningioma)" + }, + { + "input": "Definition: Disease or Syndrome described as igA nephropathy secondary to a genetic mutation that is transmitted from parents to offspring.\nConcepts: FACIT-F Version 4 - I Have Accepted My Illness (Intellectual Product)\tIgA Nephropathy, Familal (Primary immunoglobulin A nephropathy)\tCuffs, Pneumatic Tourniquet, Single Bladder, Contoured, Reusable (Cuffs, Pneumatic Tourniquet, Single Bladder, Contoured)\thistidine:histamine antiporter activity (cation:cation antiporter activity)\tcoix seed extract (Antineoplastic Agents)", + "output": "IgA Nephropathy, Familal (Primary immunoglobulin A nephropathy)" + }, + { + "input": "Definition: something described as the phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition.\nConcepts: Anesthesia ventilator (Device associated with anaesthesia systems)\tIsomerisms (Organic Chemistry Phenomena)\tGLI3 Protein (TRANSCRIPTION FACTOR)\tnucleoside diphosphate biosynthesis (Molecular Function)\tExcision of thyroid gland (Thyroidectomy)", + "output": "Isomerisms (Organic Chemistry Phenomena)" + }, + { + "input": "Definition: SIQ-JR Questionnaire Question described as suicidal Ideation Questionnaire-Junior (SIQ-JR) I thought about how I would kill myself.\nConcepts: Size (Quantitative Concept)\tCSS0304A (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tDural tail sign (Abnormal spinal meningeal morphology)\tRefractory Desmoplastic Small Round Cell Tumor (Neoplastic Process)\tSIQ-JR - I Thought How I Would Kill Myself (SIQ-JR Questionnaire Question)", + "output": "SIQ-JR - I Thought How I Would Kill Myself (SIQ-JR Questionnaire Question)" + }, + { + "input": "Definition: something described as the progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus.\nConcepts: Substantia intermedia centralis medullae spinalis (Body Part, Organ, or Organ Component)\tPIG19 (Gene or Genome)\tMN1 GENE (Gene or Genome)\tAdult Diffuse Small Non-Cleaved Cell Lymphoma Stage II (Ann Arbor Stage II Aggressive Adult Non-Hodgkin Lymphoma)\tanterior pituitary gland development (Organ or Tissue Function)", + "output": "anterior pituitary gland development (Organ or Tissue Function)" + }, + { + "input": "Definition: something described as any process that modulates the frequency, rate or extent of viral release from host cell.\nConcepts: FIQR01-Lift/Carry Bag Full of Groceries (Intellectual Product)\tMAb cA2 (Serology)\tVulvar Trichoepithelioma (Vulvar Neoplasm of Skin Appendage Origin)\tregulation of release of virus from host (Biologic Function)\tLugano Classification Stage II Adult Lymphoma AJCC v8 (Lugano Classification Limited Stage Adult Lymphoma AJCC v8)", + "output": "regulation of release of virus from host (Biologic Function)" + }, + { + "input": "Definition: Finding described as a molecular finding indicating that the mutation rate is higher than 10 mutations per megabase (Mb) in a tissue sample.\nConcepts: Hypermutated Sample (Finding)\tnuclear proteasome complex (proteasome complex location)\tThread (Computer software)\tLacrimal Gland Carcinoma TNM Finding v8 (Ophthalmic Sites Cancer TNM Finding v8)\tKYMOGR (Plain X-ray techniques)", + "output": "Hypermutated Sample (Finding)" + }, + { + "input": "Definition: something described as interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.\nConcepts: phosphatidylinositol 3-phosphate binding (phosphatidylinositol phosphate binding)\tMale pubertal stage (Pubertal stage)\tAntiestrogen Therapy Agent (Hormones and their metabolites and precursors)\tMIR382 wt Allele (MIR382 gene)\tImmune Costimulatory Protein B7-H4 (B7 Antigens)", + "output": "phosphatidylinositol 3-phosphate binding (phosphatidylinositol phosphate binding)" + }, + { + "input": "Definition: something described as the protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell.\nConcepts: auxin efflux carrier complex location (Cell Component)\tParallel Trial (Research Activity)\tC-SSRS Lifetime/Recent Version - Frequency of Most Severe Ideation (C-SSRS Lifetime/Recent Version Questionnaire Question)\tendodontic files (Dental equipment and devices)\tKarnofsky 80-90 (Zubrod Performance Status)", + "output": "auxin efflux carrier complex location (Cell Component)" + }, + { + "input": "Definition: Organism Function described as any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.\nConcepts: A4STR1-Time to Ascend 4 Stairs (4 Stair Ascend Functional Test Question)\tresponse to abiotic stimulus (Organism Function)\tPacemaker Lead Adapters, Implantable (Leads)\tprotein a (Amino Acid, Peptide, or Protein)\tPolyneuropathy, intellectual disability, acromicria, premature menopause syndrome (Multiple malformation syndrome with limb defect as major feature)", + "output": "response to abiotic stimulus (Organism Function)" + }, + { + "input": "Definition: Tissue described as the tissue that forms the wall of the small and large intestine. It consists of mucosa, submucosa, muscular coat, and serosal surface.\nConcepts: Intestinal Wall Tissue (Body tissue)\tLeucine-Rich Repeats and Immunoglobulin-Like Domains 3 Gene (Genes, Regulator)\tOMAN (Arabian Peninsula)\tVFQ207 (VFQ25-Self Administered Format Questionnaire Question)\tMacrophage Antigen Alpha Polypeptide (Amino Acid, Peptide, or Protein)", + "output": "Intestinal Wall Tissue (Body tissue)" + }, + { + "input": "Definition: Chlorides described as a salt of lithium that has been used experimentally as an immunomodulator.\nConcepts: frizzled signalling pathway involved in mDA neuron differentiation (Wnt Signaling Pathway)\tIntersex Person (Population Group)\tIncreased width of permanent upper central incisor (Incisor macrodontia)\tLITHIUM CHLORIDE (Antidepressive Agents)\tcross presentation (Cell Function)", + "output": "LITHIUM CHLORIDE (Antidepressive Agents)" + }, + { + "input": "Definition: something described as an abnormal communication between the rectum, bladder, and vagina.\nConcepts: Carcinomatous ascites (Neoplastic Process)\tAplasia of the olfactory tract (Abnormality of forebrain morphology)\tImmunization Schedules (Immunization)\tDNA double-strand break processing involved in repair via synthesis-dependent strand annealing (Genetic Function)\tRecto-Vesico-Vaginal Fistula (Disease or Syndrome)", + "output": "Recto-Vesico-Vaginal Fistula (Disease or Syndrome)" + }, + { + "input": "Definition: MACC1 gene described as human MACC1 wild-type allele is located in the vicinity of 7p21.1 and is approximately 83 kb in length. This allele, which encodes metastasis-associated in colon cancer protein 1, is involved in promoting both cell motility and cell proliferation. Expression of this gene in colon cancers is a prognostic indicator for metastasis formation.\nConcepts: Grade 1 Muscle Weakness Right-Sided, CTCAE (Muscle Weakness Right-Sided, CTCAE)\tDrug Delivery System Category (Biomedical or Dental Material)\tPML wt Allele (PML gene)\tSH3BP4L (Gene or Genome)\tThird Ventricle Germinoma (Neoplastic Process)", + "output": "SH3BP4L (Gene or Genome)" + }, + { + "input": "Definition: congenital conditions described as a deformity of the foot which occurs at birth in which one or both feet are twisted\nConcepts: glycerol-3-phosphate 2-O-acyltransferase activity (O-acyltransferase activity)\tneurotransmitter receptor biosynthetic process (neurotransmitter receptor metabolic process)\tCongenital talipes equinovarus (Congenital clubfoot)\tCortical actin cytoskeleton (Cortical cytoskeleton)\tmelanoma, stage I (stage, melanoma)", + "output": "Congenital talipes equinovarus (Congenital clubfoot)" + }, + { + "input": "Definition: something described as a genetic finding indicating that codon 600 of the BRAF gene encodes the wild type amino acid, valine.\nConcepts: Yucatan Minature pig breed (Mammal)\tHaemophilus haemolyticus, Beta-Lactamase Positive (Haemophilus haemolyticus)\tVZFPB (Quantitative Concept)\tBRAF V600 Wildtype (BRAF Gene Mutation Negative)\tAncriviroc (Pharmacologic Substance)", + "output": "BRAF V600 Wildtype (BRAF Gene Mutation Negative)" + }, + { + "input": "Definition: Glycerophospholipid metabolic process described as the chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.\nConcepts: p44MAPK protein, human (Amino Acid, Peptide, or Protein)\tphosphatidylcholine metabolic process (Molecular Function)\ttrinitrotoluene metabolic process (Molecular Function)\tCarbohydrate Conformations (Molecular Conformation)\tcell motility involved in camera-type eye morphogenesis (cell motility)", + "output": "phosphatidylcholine metabolic process (Molecular Function)" + }, + { + "input": "Definition: Cell Component described as the component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.\nConcepts: ICC (Enteric Nervous System)\tcares, Informal (Health Care Activity)\tnegative regulation of nematode male tail tip morphogenesis (negative regulation of reproductive process)\textrinsic to endosome membrane (extrinsic component of organelle membrane)\tSubstance with serine proteinase inhibitor mechanism of action (Pharmacologic Substance)", + "output": "extrinsic to endosome membrane (extrinsic component of organelle membrane)" + }, + { + "input": "Definition: something described as the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell and contributing to the commitment of a cell to an arterial endothelial cell fate.\nConcepts: Notch signalling pathway involved in arterial endothelial cell fate commitment (Molecular Function)\tautologous anti-CD33 CAR-T cells (Antineoplastic Immune Cell)\ttherapeutic leukopheresis (BLOOD PROCEDURES AND TRANSFUSIONS)\tSpina bifida occulta at L5 (Congenital Abnormality)\tIndian rhubarb (Fruit or Vegetable)", + "output": "Notch signalling pathway involved in arterial endothelial cell fate commitment (Molecular Function)" + }, + { + "input": "Definition: something described as a response indicating that an individual is or was bothered some, enough to notice.\nConcepts: CDISC Questionnaire GAD-7 Test Name Terminology (CDISC Questionnaire Terminology)\tBothered some, enough to notice (Clinical or Research Assessment Answer)\tPyrexia postprocedure (Other specified fever)\tdinucleotide repeat insertion binding (Genetic Function)\thydroxycinnamoyltransferase activity (Molecular Function)", + "output": "Bothered some, enough to notice (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: something described as a hyperplasia of the squamous epithelial cells.\nConcepts: Squamous Hyperplasia (Hyperplasia)\tEXPORTIN 1 (Gene or Genome)\tCOVER, SHOE, OPERATING-ROOM (Medical Device)\tRefractory Langerhans Cell Histiocytosis (Neoplastic Process)\tComputed Tomography (Image Interpretation, Computer-Assisted)", + "output": "Squamous Hyperplasia (Hyperplasia)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Actinomyces turicensis.\nConcepts: Incompetence;mitral (MYO ENDO PERICARDIAL & VALVE DISORDERS)\thycanthone (Thioxanthenes)\t2-deoxystreptamine breakdown (antibiotic catabolic process)\tACTINOMYCES TURICENSIS (Aerotolerant Actinomyces species)\tGallbladder Cancer pM1 TNM Finding v8 (Gallbladder Cancer Pathologic Distant Metastasis TNM Finding v8)", + "output": "ACTINOMYCES TURICENSIS (Aerotolerant Actinomyces species)" + }, + { + "input": "Definition: Seafood causing toxic effect described as a condition caused by ingestion of shellfish contaminated by domoic acid-producing diatoms of the genus Pseudo-nitzschia.\nConcepts: URINARY HOMOCYSTINE (NONQUANTITATIVE) TEST SYSTEM (Medical Device)\tBeta thalassaemia X-linked thrombocytopenia syndrome (Congenital anemia)\tShellfish Poisonings, Amnesic (POISONING BY ARTHROPODS AND OTHER ANIMALS)\tgentian family (Plant)\tLoss of Mitochondrial Complex II Expression (Protein Deregulation)", + "output": "Shellfish Poisonings, Amnesic (POISONING BY ARTHROPODS AND OTHER ANIMALS)" + }, + { + "input": "Definition: Rare Non-Neoplastic Disorder described as a chronic, benign, inflammatory condition that is characterized by the swelling of lymph node in the head and neck.\nConcepts: Administration of medication, therapeutic (Introduction procedure)\tHypertensive Crisis (Hypertensive diseases)\tobsolete juvenile hormone binding (Molecular Function)\tSerum serotonin increased (Finding)\tKimura's Disease (Salivary Gland Diseases)", + "output": "Kimura's Disease (Salivary Gland Diseases)" + }, + { + "input": "Definition: Medical Device described as a cardiopulmonary bypass pulsatile flow generator is an electrically and pneumatically operated device used to create pulsatile blood flow. The device is placed in a cardiopulmonary bypass circuit downstream from the oxygenator.\nConcepts: Abdominal reflex absent (Integumentary System Finding)\tPHOTODYNAMIC THER (neoplasm/cancer radiation therapy)\tGENERATOR, PULSATILE FLOW, CARDIOPULMONARY BYPASS (Medical Device)\tFrequent menses (Abnormality of the menstrual cycle)\turine tests nonspecific abnormal findings hypocitraturia (Urine screening abnormal)", + "output": "GENERATOR, PULSATILE FLOW, CARDIOPULMONARY BYPASS (Medical Device)" + }, + { + "input": "Definition: Gene or Genome described as human UNC45A wild-type allele is located in the vicinity of 15q26.1 and is approximately 24 kb in length. This allele, which encodes protein unc-45 homolog A, is involved in both cell differentiation and muscle development.\nConcepts: chloroplast avoidance movement (chloroplast relocation)\tAbnormality of citric acid cycle (Finding)\tGCUNC45 (UNC45A gene)\tcabiralizumab (Monoclonal Antibodies)\tVopratelimab (Pharmacologic Substance)", + "output": "GCUNC45 (UNC45A gene)" + }, + { + "input": "Definition: Pain of digestive structure described as a painful sensation in the liver.\nConcepts: Mcl-1 Inhibitor (Antineoplastic Agents)\tmodulation of preblastoderm mitotic cell cycle progression (Cell Function)\tprotein-macromolecule adaptor activity (molecular adaptor activity)\tLiver pain (Pain)\tBasal segment of circumflex branch of left coronary artery (Body Location or Region)", + "output": "Liver pain (Pain)" + }, + { + "input": "Definition: something described as mild symptoms; intervention not indicated\nConcepts: Grade 1 Testes hemorrhage (Testicular Hemorrhage, CTCAE)\tDistended (General Qualifier)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG, ATXN2 Gene (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Trinucleotide Repeats, CAG)\tactivation of MAPKK activity (positive regulation of MAP kinase activity)\tClonorchis sinensis infection (Parasite infestation)", + "output": "Grade 1 Testes hemorrhage (Testicular Hemorrhage, CTCAE)" + }, + { + "input": "Definition: something described as breast cancer in which there is more than one tumor, all of which have formed separately from one another. The tumors are likely to be in different quadrants (sections) of the breast. Multicentric breast cancers are rare.\nConcepts: frank breech presentation (Breech Presentation)\tfragile skin (Disease of Skin and Appendages)\tMulticentric Breast Carcinoma (Neoplastic Process)\tManden Language (Mande language)\tgastrointestinal pharmacology (Pharmacology)", + "output": "Multicentric Breast Carcinoma (Neoplastic Process)" + }, + { + "input": "Definition: Sarcoma of soft tissue described as a malignant soft tissue neoplasm that arises from the structures of the orbit. The majority of the cases are rhabdomyosarcomas.\nConcepts: Columnar epithelium with microvilli (Simple columnar epithelium)\tINFECT ENCEPH VIRAL (Encephalitis of viral origin)\tautologous anti-HLA-A*0201/AFP CAR-T cells ET1402L1 (Antineoplastic Immune Cell)\tSarcoma of Orbit (Malignant tumor of orbit)\tKi-Ras Q61E (Cell or Molecular Dysfunction)", + "output": "Sarcoma of Orbit (Malignant tumor of orbit)" + }, + { + "input": "Definition: Anxiety disorders NEC in MDR described as psychoanalytic term referring to mental conditions characterized primarily by anxiety, fears, obsessive thoughts, compulsions, dissociation, and depression. Neuroses have no organic origins and are believed to be a product of unconscious processes resulting from internal conflicts. Compare PSYCHOSIS.\nConcepts: Tyrosine-Protein Kinase JAK1 Inhibitor (Protein-tyrosine kinase inhibitor)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, DSG2 (Medical Device)\tNEUROSIS (Anxiety neurosis)\ttesticular cancer, embryonal carcinoma and yolk sac tumor with seminoma (Neoplastic Process)\tintegrin alpha10, human (Cell Adhesion Molecules)", + "output": "NEUROSIS (Anxiety neurosis)" + }, + { + "input": "Definition: something described as the cuneate nucleus of the medulla and the gracile nucleus located in the spinomedullary junction at the rostral end of each posterior white column ( Carpenter-1983 ).\nConcepts: Sulfonamides (ANTI-INFECTIVE AGENTS FOR BACTERIA, VIRUSES AND FUNGI)\tPositioning Therapy (Neurodevelopmental techniques)\tchromosome-kinetochore attachment (cellular protein-containing complex assembly)\tposterior column medullary relay nuclei (Body Part, Organ, or Organ Component)\tComplement C5, Free (Complement C5 Measurement)", + "output": "posterior column medullary relay nuclei (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Cell Function described as the controlled release of octopamine by a cell, in which the octopamine acts as a neurotransmitter.\nConcepts: Exacerbated by smoking (Finding)\tN Nitrosodimethylamine (Carcinogenic Nitrosamine)\toctopamine secretion, neurotransmission (neurotransmitter release)\tSlurry (Mixture)\tWedge Resection (Surgical incisions)", + "output": "octopamine secretion, neurotransmission (neurotransmitter release)" + }, + { + "input": "Definition: Organic Chemical described as snap dragon.\nConcepts: Genomic Islands (Interspersed Repetitive Sequences)\tHistory of recent animal bite (Finding)\tLinaria vulgaris / snap dragon (Pharmacologic Substance)\tScanning Systems, Laser, Mammographic (Scanning Systems, Laser)\tEast Asia (Asia)", + "output": "Linaria vulgaris / snap dragon (Pharmacologic Substance)" + }, + { + "input": "Definition: Medical & Physical Treatment described as branch of psychiatry concerned with the provision and delivery of a coordinated program of mental health care to a specified population. The foci included in this concept are: all social, psychological and physical factors related to etiology, prevention, and maintaining positive mental health in the community.\nConcepts: Community Psychiatry (Treatment (General))\tSample Purification from Cell Culture (Biospecimen Collection Method)\tAntigen, Carcinoembryonic (Cell Adhesion Molecules)\tAzelains\u00e4ure (Other anti-acne preparations for topical use in ATC)\tSystemic part relation (Intellectual Product)", + "output": "Community Psychiatry (Treatment (General))" + }, + { + "input": "Definition: Guanidines described as a biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent.\nConcepts: Nasobuccal fissure (Body Space or Junction)\tMarfan's Syndrome (Musculoskeletal and connective tissue disorders of limbs congenital)\tspurious pregnancy (Female reproductive finding)\tpopulationScopeCode (Code)\tProduct containing chlorhexidine (Anti-Infective Agents, Local)", + "output": "Product containing chlorhexidine (Anti-Infective Agents, Local)" + }, + { + "input": "Definition: Other blood glucose lowering drugs, excl. insulins in ATC described as a succinic acid derivative with hypoglycemic activity. Like other meglitinide-type compounds, mitiglinide has a high affinity for SUR1 subunits.\nConcepts: LIBYA (Africa, Northern)\tMitiglinide (Organic Chemical)\tButirosin Sulfate (Antibiotics, Aminoglycoside)\tComplement C1q Antibody Measurement (Complement Measurement)\tADL0202 (Intellectual Product)", + "output": "Mitiglinide (Organic Chemical)" + }, + { + "input": "Definition: something described as a fusion protein containing a modified form of human T-cell receptor (TCR) specific for the gp100 antigen and fused to an anti-CD3 single-chain antibody fragment, with potential antineoplastic activity. Upon direct intratumoral administration of IMCgp100 into the melanoma lesion, the TCR moiety of this agent targets and binds to the tumor associated antigen (TAA) gp100 presented on the melanoma tumor cell; the anti-CD3 fragment moiety binds to CD3- expressing T lymphocytes, thereby selectively cross-linking tumor cells and T-lymphocytes. This may lead to the recruitment of cytotoxic T lymphocytes (CTL) to the T lymphocyte/tumor cell aggregates and result in CTL-mediated death of gp100-expressing melanoma cancer cells.\nConcepts: ImmTAC-gp100 (Immunologic Factor)\tCitrate (si)-Synthase (Amino Acid, Peptide, or Protein)\tLead Placement Bipolar Uncorrected XYZ (Conceptual Entity)\tregulation of fatty acid beta-oxidation (regulation of fatty acid oxidation)\trelaxation therapies (Behavior Therapy)", + "output": "ImmTAC-gp100 (Immunologic Factor)" + }, + { + "input": "Definition: something described as life Events Checklist for DSM-5 Standard Version (LEC-5 Standard Version) Exposure to toxic substance (for example, dangerous chemicals, radiation): Learned about it.\nConcepts: FACT-LYM Version 4 - Bothered by Lumps or Swelling (Intellectual Product)\tMicrovessels (Blood Vessel)\tLEC0105C (Intellectual Product)\tchlorhexidine (Biguanides)\tPineal Body Neoplasm (Nervous system neoplasms malignant and unspecified NEC)", + "output": "LEC0105C (Intellectual Product)" + }, + { + "input": "Definition: Chromatography, Affinity described as a method to purify proteins or peptides from a mixture that leverages their affinity to positively charged ions immobilized on NTA-agarose beads.\nConcepts: occupational counseling (Counseling)\tInfiltrating Prostate Carcinoma (Invasive Carcinoma)\tIMAC (Laboratory Procedure)\tOcular pain, unspecified eye (Eye)\tregulation of dopamine receptor signalling pathway (regulation of signal transduction)", + "output": "IMAC (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a cancer vaccine containing xenogenic DNA from rhesus macaque (Macaca mulatta) that encodes prostate specific antigen (PSA) with potential immunostimulating and antineoplastic activities. Upon repeated intradermal administration via electroporation, pVAXrcPSAv53l vaccine may induce a cytotoxic T-lymphocyte (CTL) response against PSA-expressing prostate cancer cells. Rhesus PSA is 89% homologous to human PSA. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C82352\" active clinical trials using this agent.\nConcepts: Operating Microscopes (Medical Device)\tlateral plate mesodermal cell differentiation (mesodermal cell differentiation)\tNEXT (Study Activity)\tCatheter Ablation (interventional cardiac catheterization)\tpVAXrcPSAv53l vaccine (Pharmacologic Substance)", + "output": "pVAXrcPSAv53l vaccine (Pharmacologic Substance)" + }, + { + "input": "Definition: something described as a test result indicating the presence of red cells of various sizes and shapes in the peripheral blood.\nConcepts: AVL0203 (Intellectual Product)\tTHCKN (Qualitative Concept)\tAnisopoikilocytosis (Poikilocytosis)\tMonoclonal Antibody COL-6 (Immunologic Factor)\tELISA/ACT(R) Diagnostic Candida Albicans Test Block each test (Allergy testing)", + "output": "Anisopoikilocytosis (Poikilocytosis)" + }, + { + "input": "Definition: Organic acid and organic acid derivative described as the hydrochloride salt form of hexaminolevulinate, a hexyl ester of the heme precursor 5-aminolevulinic acid (ALA) with potential photosensitizing activity. Hexaminolevulinate serves as a precursor of photoactive porphyrins (PAPs), particularly protoporphyrin IX (PpIX), which selectively accumulate in rapidly proliferating cells, such as those seen in tumor tissue. When exposed to blue light, PAPs are activated and emit red light thereby allowing tumor imaging.\nConcepts: bicuspid valve (Left side of heart)\tantimonite transport (Cell Function)\tHexaminolevulinate Hydrochloride (Organic acid and organic acid derivative)\tRash;nappy (Disorder of skin of trunk)\tZone 18 of left marginal artery (Zone of left marginal artery)", + "output": "Hexaminolevulinate Hydrochloride (Organic acid and organic acid derivative)" + }, + { + "input": "Definition: tamoxifen described as a tamoxifen metabolite with both estrogenic and anti-estrogenic effects. Afimoxifene has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C975\" active clinical trials using this agent.\nConcepts: protein-lipid complex assembly (protein-containing complex assembly)\tSGRQ Past 4 Weeks Version - Breathing Makes Difficult to Do Heavy Manual Work (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)\tOther Problem Visual Analogue Scale (Research or Clinical Assessment Tool)\t4OH-tamoxifen (tamoxifen)\tLimb salvage (Orthopedic Procedures)", + "output": "4OH-tamoxifen (tamoxifen)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Cognitive Function Version 3 (FACT-COG Version 3) Perceived Cognitive Impairments: I have had trouble recalling the name of an object while talking to someone.\nConcepts: FAC075-Trouble Recalling Name of Object (Intellectual Product)\tFreezers, Food, Walk-In (Manufactured Object)\tThymolum / thyme camphor (Organic Chemical)\tLevel 1 Dysfunctional Second Stage of Labor (GAIA Dysfunctional Labor Level of Diagnostic Certainty)\tORAL ERYTHROPLASIA (Disease or Syndrome)", + "output": "FAC075-Trouble Recalling Name of Object (Intellectual Product)" + }, + { + "input": "Definition: Racial group described as denotes the inhabitants of any of the countries of Europe, a person from there, or their descendants elsewhere.\nConcepts: Bioassay Measurement (Laboratory Procedure)\tmodulation of peptidase activity in other organism involved in symbiotic interaction (Molecular Function)\tCSS05-Suicidal Behavior-Prior (Intellectual Product)\tEuropean race (living organism) (Homo sapiens)\tfibrillin 5 (Gene or Genome)", + "output": "European race (living organism) (Homo sapiens)" + }, + { + "input": "Definition: Bones, Joints and Muscles described as calcium compounds used as food supplements or in food to supply the body with calcium; dietary calcium is needed during growth for bone development and for maintenance of skeletal integrity later in life to prevent osteoporosis.\nConcepts: Lower Gastrointestinal Therapeutic Surgical Procedure (Therapeutic or Preventive Procedure)\tdietary calcium (dietary mineral)\tfrizzled binding (G protein-coupled receptor binding)\tUTP biosynthetic process (Molecular Function)\tTubular Sweat Gland Adenomas (Adenoma, Sweat Gland)", + "output": "dietary calcium (dietary mineral)" + }, + { + "input": "Definition: Set of subarachnoid sulci described as a depression in the precentral gyrus of the macaque ( Krieg-1975 ). While some authors refer to it as the anterior subcentral sulcus ( Szabo-1984; Martin-2000 ), it differs from that sulcus in the human by lack of connection to the lateral fissure. The structure in the macaque is in closer proximity to the central sulcus than to the lateral fissure.\\r\\nEquivalent features are not seen in the smooth cerebral cortex of the rat or mouse ( NeuroNames ).\nConcepts: ethology (behavioral/social science)\tAlpha2 (Qualitative Concept)\tsubcentral dimple (Body Space or Junction)\tBody temperature, decreased (Symptomatology)\tNCCN-FACT FOSI-18 Version 2 - I Am Able to Get Around by Myself (NCCN-FACT FOSI-18 Version 2 Questionnaire Question)", + "output": "subcentral dimple (Body Space or Junction)" + }, + { + "input": "Definition: Organism Function described as the process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure.\nConcepts: excitation of vasomotor center by chemoreceptor signalling (Organism Function)\tAbnormality of the shoulder (Abnormality of the thorax)\tNon-esterified Fatty Acid, Unsaturated (Fatty acid measurement)\tRECORDER, EXTERNAL, PRESSURE, AMPLIFIER & TRANSDUCER (Medical Device)\tIxodes species (Ixodinae)", + "output": "excitation of vasomotor center by chemoreceptor signalling (Organism Function)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: (3R)-3-hydroxy-L-aspartate = glycine + glyoxylate.\nConcepts: Structure of cerebral vein (Body Part, Organ, or Organ Component)\t15min sprtl care prvdr phn c (Health Care Activity)\tBulb Squeeze Dynamometers (Medical Device)\terythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity (oxo-acid-lyase activity)\tNeonatal Abstinence Syndrome Assessment (Research or Clinical Assessment Tool)", + "output": "erythro-3-hydroxy-L(s)-aspartate glyoxylate-lyase activity (oxo-acid-lyase activity)" + }, + { + "input": "Definition: Western herbs and natural substances letter A described as mugwort herb.\nConcepts: positive regulation of DNA-templated transcription, termination (regulation of DNA-templated transcription, termination)\tartemisia vulgaris/mugwort h (Plant)\tAcademic Research Council Subacute Stent Thrombosis (Academic Research Council Coronary Stent Thrombosis Timing)\tlevobetaxolol hydrochloride (Pharmacologic Substance)\tProximal Left Anterior Descending Coronary Artery Stenosis, Percentage (Finding)", + "output": "artemisia vulgaris/mugwort h (Plant)" + }, + { + "input": "Definition: PHQ Screener Version Questionnaire Question described as patient Health Questionnaire Screener Version - Over the last 4 weeks, how often have you been bothered by getting tired very easily?\nConcepts: IDSC1-Pleasure/Enjoyment (IDS-C Clinical Classification Question)\tPHQ Screener Version - Getting Tired Easily (Intellectual Product)\tVenoms, Bee (Amino Acid, Peptide, or Protein)\tLevel 1 Neonatal Blood Stream Infection (GAIA Neonatal Infections Level of Diagnostic Certainty)\tcellular response to lipid (cellular response to organic substance)", + "output": "PHQ Screener Version - Getting Tired Easily (Intellectual Product)" + }, + { + "input": "Definition: cell migration involved in heart development described as the coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart.\nConcepts: rum flavor (Structured Product Labeling Flavor)\tproepicardium cell migration involved in pericardium morphogenesis (cell migration involved in heart development)\tNSCLC-SAQ Version 1.0 - How Often Poor Appetite (NSCLC-SAQ Version 1.0 Questionnaire Question)\tBladder Cancer pN0 TNM Finding v8 (Finding)\tEnamelysin (Matrix Metalloproteinases, Secreted)", + "output": "proepicardium cell migration involved in pericardium morphogenesis (cell migration involved in heart development)" + }, + { + "input": "Definition: something described as breast cancer with pN1a or pN2a in the presence of cN2b (positive internal mammary nodes by imaging); or pN2a in the presence of pN1b.\nConcepts: ARTHUS PHENOMENON (Immune complex urticaria)\tBreast Carcinoma pN3b TNM Finding v8 (Breast Cancer pN3 TNM Finding v8)\tSplenic Lymphoblastic Lymphoma (Neoplastic Process)\tamnionitis (Disease or Syndrome)\tCS-1003 (Anti-PD1 Monoclonal Antibody)", + "output": "Breast Carcinoma pN3b TNM Finding v8 (Breast Cancer pN3 TNM Finding v8)" + }, + { + "input": "Definition: GTF2A1 Gene Product described as transcription initiation factor IIA subunit 1 (376 aa, ~42 kDa) is encoded by the human GTF2A1 gene. This protein plays a role in transcriptional activation.\nConcepts: GITR agonist BMS-986156 (Amino Acid, Peptide, or Protein)\tTranscription Initiation Factor IIA Subunit 1 (Amino Acid, Peptide, or Protein)\tAgave tequilana / blue agave homeopathic preparation (Organic Chemical)\tRadiofrequency/Infrared/Massage Therapy Units, Cellulite (Electromechanical Devices)\tMuscle, Neck (Set of muscles)", + "output": "Transcription Initiation Factor IIA Subunit 1 (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the MET oncogene is derived from a chromosomal rearrangement involving the MET and TPR (translocated promoter region) loci and is a cloned gene for Hereditary Papillary Renal Carcinoma. The MET proto-oncogene encodes hepatocyte growth factor receptor, a disulfide-linked two subunit receptor protein tyrosine kinase. The human gene is located at 7q31.\nConcepts: EYDCOMGR (Intellectual Product)\tREADER, ZONE, AUTOMATED (Medical Device)\tMesomelic dysplasia with acral synostoses Verloes David Pfeiffer type (Hereditary Connective Tissue Disorder)\tMaintenance, Telomere Length (Genetic Function)\tMET gene (Gene Mutation)", + "output": "MET gene (Gene Mutation)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a palatal muscle with origin on the palatine aponeurosis and insertion on the tongue, serving to elevate the tongue and close the oropharyngeal isthmus, which aids in swallowing.\nConcepts: Inflammatory infiltrate (Finding)\tCMV DNA (Nucleic Acid, Nucleoside, or Nucleotide)\tGirdlestone resection arthroplasty of hip (Removal of prosthesis of joint structures of hip)\tMusculus palatoglossus (Set of extrinsic muscles of tongue)\tLow Affinity Immunoglobulin Epsilon Fc Receptor Negative (Laboratory or Test Result)", + "output": "Musculus palatoglossus (Set of extrinsic muscles of tongue)" + }, + { + "input": "Definition: Inorganic Chemical described as water from Adelheidsquelle mineral springs.\nConcepts: adelheidsquelle aqua/H2O ade (Pharmacologic Substance)\tpramlintide acetate (Amino Acid, Peptide, or Protein)\tAutologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine (Dendritic Cell Vaccine)\tbeta-hydroxybutyryl acyl carrier protein dehydrase activity (Molecular Function)\tTesla (Derived Unit of International System of Units)", + "output": "adelheidsquelle aqua/H2O ade (Pharmacologic Substance)" + }, + { + "input": "Definition: Angiogenic Process described as the process that gives rise to a glomerular capillary. This process pertains to the initial formation of a structure from unspecified parts.\nConcepts: Eclampsia 1s, Preeclampsia (Renal hypertension and related conditions)\tAntigen-specific T cell proliferation defect (Finding)\tProstate Carcinoma Metastatic to the Lung (Neoplastic Process)\t(S)-(-)-Perillyl Alcohol (Pharmacologic Substance)\tglomerular capillary formation (Angiogenic Process)", + "output": "glomerular capillary formation (Angiogenic Process)" + }, + { + "input": "Definition: something described as a congenital anomaly of the hand or foot, marked by the presence of supernumerary digits.\nConcepts: ACTL6 (Transcription Regulation Gene)\tpending (normal Entity Status)\tRegulation of Exocytosis (Exocytosis)\tINCLUSION CELL DISEASE (LABORATORY ABNORMALITIES)\tPolydactyly (disorder) [Ambiguous] (Limb structure)", + "output": "Polydactyly (disorder) [Ambiguous] (Limb structure)" + }, + { + "input": "Definition: something described as surgical instrument motors and accessories are AC-powered, battery-powered, or air-powered devices intended for use during surgical procedures to provide power to operate various accessories or attachments to cut hard tissue or bone and soft tissue. Accessories or attachments may include a bur, chisel (osteotome), dermabrasion brush, dermatome, drill bit, hammerhead, pin driver, and saw blade.\nConcepts: fecal fat anal.24 /48 / 72 h (Fecal analysis procedure)\tScheduledSubstanceAdministration.activeIngredientDose (Active Ingredient Dose)\tOvarian infection (Finding)\tSomewhat less limited than others (Intellectual Product)\tSAW, POWERED, AND ACCESSORIES (Medical Device)", + "output": "SAW, POWERED, AND ACCESSORIES (Medical Device)" + }, + { + "input": "Definition: Organism Function described as any process in which a symbiont modulates the frequency, rate or extent of the production of reactive oxygen species as part of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.\nConcepts: autonomic reflex (Organ or Tissue Function)\tPRAP (Gene or Genome)\tProne Positions (MOTOR FUNCTIONS AND DYSFUNCTIONS)\tFever, American Hemorrhagic (Disease or Syndrome)\tmodulation by organism of defense-related host respiratory burst (Immune Evasion)", + "output": "modulation by organism of defense-related host respiratory burst (Immune Evasion)" + }, + { + "input": "Definition: something described as infectious diseases originating in one geographically delineated ecosystem that are carried (by travel or immigration) to another geographically delineated ecosystem by an infected individual, animal, or disease vector.\nConcepts: negative regulation of glycerol transport (negative regulation of transport)\tMedullary Thyroid Carcinoma Clinical TNM Finding v8 (Finding)\tGastric Retention Polyp (Disease or Syndrome)\tmotor cell (Neuroanatomy)\tDisease, Infectious Imported (Communicable Diseases)", + "output": "Disease, Infectious Imported (Communicable Diseases)" + }, + { + "input": "Definition: Area Under Curve described as the area under the curve (AUC) from the time of dosing to the time of the last observation, regardless of whether the last concentration is measurable or not.\nConcepts: Nasopharyngeal Carcinoma pT0 TNM Finding v8 (Finding)\tToken Economy Programs (Therapeutic or Preventive Procedure)\tArea Under the Curve All (Quantitative Concept)\tGrade 4 Gastric fistula (Gastric Fistula, CTCAE 5)\tresponse to interleukin-12 (response to cytokine)", + "output": "Area Under the Curve All (Quantitative Concept)" + }, + { + "input": "Definition: Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage described as stage IVC includes: T0, Any N, M1. T0: No evidence of primary tumor. M1: Distant metastasis.\nConcepts: Grade 2 Lipase increased (Lipase Increased, CTCAE)\tMoving into preschool educational programme or across levels (Preschool education)\tRectal Carcinoma by AJCC v7 Stage (Colorectal Cancer by AJCC v7 Stage)\tAnomalous origin of the left common carotid artery from the brachiocephalic trunk (Abnormality of aortic arch branch)\tStage IVC Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8 (Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage)", + "output": "Stage IVC Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy AJCC v8 (Unknown Primary Tumor (Except for EBV-Related and HPV-Related Tumors) and Metastatic Cervical Adenopathy by AJCC v8 Stage)" + }, + { + "input": "Definition: Primary hypogonadism described as syndrome with the association of congenital hydrocephalus, centripetal obesity, hypogonadism, intellectual deficit and short stature. It has been described in two males from one family. An X-linked recessive mode of inheritance was suggested.\nConcepts: Prophyllin CCC (Pharmacologic Substance)\tSOST (Disease or Syndrome)\tLigature Passers, Endoscopic (Passer/Knot Tiers, Ligature)\tHydrocephalus with obesity and hypogonadism syndrome (Primary hypogonadism)\tneon (N [Preparations])", + "output": "Hydrocephalus with obesity and hypogonadism syndrome (Primary hypogonadism)" + }, + { + "input": "Definition: something described as a representation of the location of the place.\nConcepts: Occlusal scheme (Dental Occlusion)\thydrochloride pioglitazone (Thiazolidinedione Antidiabetic Agent)\tSodium-Iodide Symporter (Carrier Proteins)\tCyst of anterior chamber, NOS (Disorder of anterior chamber of eye)\tPlace.physicalAddress (Intellectual Product)", + "output": "Place.physicalAddress (Intellectual Product)" + }, + { + "input": "Definition: Manufactured Object described as testers designed to assess the main characteristics of an isolated power system. These testers typically consist of an electronic measuring unit including a display, a current generator, controls to select the test, and appropriate leads. Most isolated power system testers can test line voltage, line isolation current, and line isolation monitor and ground-fault circuit interrupter operation and trip current; they are used after installation, in preventive maintenance procedures, and after power system modification or repair.\nConcepts: Isolated Power System Testers (Tester device)\tRenal Tubular Acidosis (MISCELLANEOUS METABOLIC DISORDERS OF TRANSPORT, NEC)\tLinkage (Thesaurus of Psychological Index Terms)\tGlobohexaosylceramide (Organic Chemical)\tInterventionalStudyProtocolVersion.interventionDescription (Intellectual Product)", + "output": "Isolated Power System Testers (Tester device)" + }, + { + "input": "Definition: Dwarfism described as a rare genetic adrenal disorder with characteristics of congenital bronzed hyperpigmentation, cutis laxa of the hands and feet, body disproportion (comprising large hands, feet, nose and ears), hirsutism and severe intellectual disability. Patients additionally present hyperadrenocorticism, cushingoid features, premature adrenarche and diabetes mellitus, as well as skeletal deformities (not present at birth and which progress with age). There have been no further descriptions in the literature since 1981.\nConcepts: estrogen binding (Molecular Function)\tDecreased width of nasal base (Abnormal nasal base)\tBilateral Acoustic Neurofibromatoses (Neoplasm of uncertain behavior of acoustic nerve)\tPatterson's leprechaunoid syndrome (Adrenal hyperfunction)\tTreatment Effectiveness Evaluation (Occupational Activity)", + "output": "Patterson's leprechaunoid syndrome (Adrenal hyperfunction)" + }, + { + "input": "Definition: Drug allergens described as essential oil extracted from MELALEUCA ALTERNIFOLIA (tea tree). It is used as a topical antimicrobial due to the presence of terpineol.\nConcepts: Melaleuca alternifolia Oil (Organic Chemical)\tXylan Hydrolases (Glycoside Hydrolases)\tTUSPLIT (Finding)\tregulation of mesenchymal stem cell apoptotic process involved in metanephric nephron morphogenesis (Biologic Function)\tpositive regulation of amide metabolism (regulation of cellular amide metabolic process)", + "output": "Melaleuca alternifolia Oil (Organic Chemical)" + }, + { + "input": "Definition: something described as the process whose specific outcome is the progression of the metanephric proximal tubule over time, from its formation to the mature structure. The metanephric proximal tubule is a metanephric nephron tubule that connects Bowman's capsule to the descending thin limb of the loop of Henle in the metanephros. It has a brush border epithelial morphology.\nConcepts: Amino Acid Test Clinical Chemistry Reagents (Medical Device)\tmetanephric proximal tubule development (metanephric nephron tubule development)\tNIV (Virus)\tquestionnaires Center For Epidemiologic Studies Depression Scale (depression scale)\tOccupational Fire Fighting Smoke Exposure (Finding)", + "output": "metanephric proximal tubule development (metanephric nephron tubule development)" + }, + { + "input": "Definition: something described as lipoma-preferred partner (612 aa, ~66 kDa) is encoded by the human LPP gene. This protein may be involved in cell motility or cell shape.\nConcepts: Data Management Convention (Policy)\tlight-activated ion channel activity (ion channel activity)\tTachyarrhythmia, NOS (Cardiac Arrhythmia)\tBiodynamic Imaging (Diagnostic Procedure)\tLIM Domain-Containing Preferred Translocation Partner in Lipoma (Biologically Active Substance)", + "output": "LIM Domain-Containing Preferred Translocation Partner in Lipoma (Biologically Active Substance)" + }, + { + "input": "Definition: Miscellaneous Molecular Biology Terms described as any variance from the expected 1:1 ratio for the expression of the two inherited parental alleles for the same gene.\nConcepts: Allele Imbalance (Cell or Molecular Dysfunction)\tStage II Testicular Yolk Sac Tumor AJCC v6 (Testicular and epididymal neoplasms)\tChronic Lymphoid Leukemia in Remission (CLINICAL CLASSIFICATION OF NEOPLASMS OF THE HEMATOPOIETIC AND IMMUNE SYSTEMS)\tmolecular function regulator (Molecular Function)\tCyclic citrullinated peptide antibody measurement (Laboratory Procedure)", + "output": "Allele Imbalance (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Paraspinal Muscles described as a group of three paired epaxial muscle bundles (iliocostalis, longissimus, and spinalis) extending along and lateral to the spinous processes of the cervical, thoracic, and lumbar vertebrae; primary function is extension and rotation of the spine.\nConcepts: Myotonia, Chondrodystrophic (Spondyloepiphyseal dysplasia, congenita)\tBiophysics, Other (Biomedical Occupation or Discipline)\tVZFOW (Observed Volume of Distribution of Absorbed Fraction)\tMUSCLE, ERECTOR SPINAE (Set of postvertebral muscles)\tBenign Non-Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm (Neoplastic Process)", + "output": "MUSCLE, ERECTOR SPINAE (Set of postvertebral muscles)" + }, + { + "input": "Definition: Mediastinal Diseases described as a malignant neoplasm of the thymus, originating from epithelial thymus cells.\nConcepts: suppression by virus of host molecular function (Organism Function)\tSodio acetato (acetate)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SLC12A6 (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tthymoma (Neoplastic Process)\tPopulation Attributable Risk (Risk Estimate)", + "output": "thymoma (Neoplastic Process)" + }, + { + "input": "Definition: something described as single-bladder cuffs intended for a single-use (i.e., disposable) including an inflatable bladder and a standard (typically cylindrical or rectangular) shape that are designed to exert a pressure on the circumference of an extremity by means of a compressed gas delivered by a pneumatic tourniquet. These devices usually include one bladder within the cuff that is inflated through tubes (e.g., hoses) that run from the bladder connectors to the source of compressed air located in the control unit of the tourniquet. The cuff is fastened to the extremity using contact mechanisms (e.g., clips) and frequently secured with an external ribbon. Disposable single-bladder standard cuffs are usually supplied sterile in individual pouches for only one use and are not intended for sterilization processes at the healthcare facility; they are usually made of one integral unit with components (e.g., bladder) that cannot be replaced. The cuffs are used mainly during surgical procedures in the extremities using general anesthesia that need a completely sterile operating field. Disposable standard single-bladder cuffs are intended for use in specific extremity areas (e.g., arm, thigh, wrist, ankle) are available. Dedicated disposable non-standard cuffs with a smaller diameter distally than proximal when wrapped (i.e., contoured cuffs) are also available.\nConcepts: Fc fragment of IgG, low affinity IIb, receptor for (Gene or Genome)\tBenzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))) (Organic Chemical)\tbasolateral plasma membrane (Region of plasma membrane)\tterpene metabolic process (Molecular Function)\tCuffs, Pneumatic Tourniquet, Single Bladder, Standard, Disposable (Medical Device)", + "output": "Cuffs, Pneumatic Tourniquet, Single Bladder, Standard, Disposable (Medical Device)" + }, + { + "input": "Definition: Cell Component described as a chromosome band present on 11q\nConcepts: Sexual Function (Findings-Based Question)\tEyeglass Lens Edgers (Ophthalmological Equipment and Supplies)\tplatelet dense granule membrane (Secretory granule membrane)\t11q23.3 (Cell Component)\tCullin 2 wt Allele (Gene or Genome)", + "output": "11q23.3 (Cell Component)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity. Upon oral administration, sotagliflozin binds to and blocks both SGLT1 in the gastrointestinal (GI) tract and SGLT2 in the kidneys, thereby suppressing the absorption of glucose from the GI tract and the reabsorption of glucose by the proximal tubule into the bloodstream, respectively. This decreases glucose uptake and enhances the urinary excretion of glucose, which lowers and/or normalizes blood glucose levels. SGLT1 is the primary transporter responsible for glucose absorption from the GI tract. SGLT2, a transport protein exclusively expressed in the proximal renal tubules, mediates approximately 90% of renal glucose reabsorption from tubular fluid.\nConcepts: Bladder Adenocarcinoma, Recurrent (Bladder Neoplasm)\tCentroblastic lymphoma recurrent (Malignant lymphoma centroblastic, diffuse)\tPerinatal intracranial hemorrhage (Fetal &/or neonatal hemorrhage)\tHelio fast rubin BBL (Anthraquinones)\tBeta-l-Xylopyranoside, methyl 5-C-(4-chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-thio-, (5S)- (Sodium-glucose co-transporter 2 (SGLT2) inhibitors)", + "output": "Beta-l-Xylopyranoside, methyl 5-C-(4-chloro-3-((4-ethoxyphenyl)methyl)phenyl)-1-thio-, (5S)- (Sodium-glucose co-transporter 2 (SGLT2) inhibitors)" + }, + { + "input": "Definition: Molecular Function described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement.\nConcepts: Stage IVB Mouth Squamous Cell Carcinoma (Stage IVB Lip and Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7)\tpeptide:proton symporter activity (Molecular Function)\tIMP salvage (Molecular Function)\tNucleotidyltransferase -RETIRED- (Transferase)\tExcessive growth rate (Finding)", + "output": "peptide:proton symporter activity (Molecular Function)" + }, + { + "input": "Definition: Biologically Active Substance described as insulin-like growth factor 2 mRNA-binding protein 2 (599 aa, ~66 kDa) is encoded by the human IGF2BP2 gene. This protein plays a role in the translation, localization and stability of mRNA.\nConcepts: regulation of ureidospore formation (regulation of asexual sporulation resulting in formation of a cellular spore)\tClostridium oedematens beta- and gamma-toxins (Enzyme)\tThis doctor can take care of almost any medical problem I might have (Intellectual Product)\tabsorbable fibrin sealant patch (Hemostatic Agents)\tinsulin-like growth factor 2 mRNA binding protein 2, human (RNA-Binding Proteins)", + "output": "insulin-like growth factor 2 mRNA binding protein 2, human (RNA-Binding Proteins)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels.\nConcepts: Dornase Alfa Inhalation Solution (Clinical Drug)\tethylbenzene metabolic process (Molecular Function)\tFAC084-Part II: Lifting 10-20 Lbs (Intellectual Product)\tcarnitine transmembrane transport (Cell Function)\t2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine (Antiprotozoal Agents)", + "output": "ethylbenzene metabolic process (Molecular Function)" + }, + { + "input": "Definition: cytoskeletal protein binding described as interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules.\nConcepts: tubulin binding (Binding)\t5,10-Methylenetetrahydrofolate reductase (reduced flavin adenine dinucleotide) (Oxidoreductase)\tFAC06208 (Intellectual Product)\tNo Steady Place to Sleep at Night (Living quarters)\tFinger Ring Remover/Cutters (Medical Device)", + "output": "tubulin binding (Binding)" + }, + { + "input": "Definition: Laurence-Moon Syndrome described as an autosomal recessive condition characterized by hypogonadism; spinocerebellar degeneration; MENTAL RETARDATION; RETINITIS PIGMENTOSA; and OBESITY. This syndrome was previously referred to as Laurence-Moon-Biedl syndrome until BARDET-BIEDL SYNDROME was identified as a distinct entity. (From N Engl J Med. 1989 Oct 12;321(15):1002-9)\nConcepts: laurence moon biedl syndrome (Syndrome)\tHEMATOXYLIN WEIGERT'S (Organic Chemical)\tUterine Corpus Adenosarcoma pNX TNM Finding v8 (Uterine Corpus Adenosarcoma Pathologic Regional Lymph Nodes TNM Finding v8)\tANGIOLIPOMA MICROTHROMBOTICUM (Familial neoplastic disease)\tPhysiology, Bacterial (Microbiological Phenomena)", + "output": "laurence moon biedl syndrome (Syndrome)" + }, + { + "input": "Definition: Finding described as gastrointestinal stromal tumor with distant metastasis.\nConcepts: VFQ2A11A (VFQ25-Self Administered Format Questionnaire Question)\tDakins Fluid (Pharmacologic Substance)\tAbsent in Melanoma 1 (Biologically Active Substance)\tGIST cM1 TNM Finding v8 (Finding)\tPars lateralis fasciculi dorsalis (Spinal cord, roots and ganglia structure)", + "output": "GIST cM1 TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Pharmacologic Substance described as a substance that is being studied in the treatment of cancer. It belongs to the families of drugs called synthetic retinoids and angiogenesis inhibitors.\nConcepts: axonal transport (Cytoplasmic streaming)\tamsilarotene (Retinoids)\tC-SSRS Children's Baseline - Active Suicidal Ideation with Some Intent to Act, without Specific Plan (Intellectual Product)\tbody fluid viscosity (Viscosity)\tBETA HYDROXYSTEROID DEHYDROGENASE A 11 TYPE 2 (11-beta-Hydroxysteroid Dehydrogenases)", + "output": "amsilarotene (Retinoids)" + }, + { + "input": "Definition: something described as combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.\nConcepts: CENTRIFUGES (MICRO, ULTRA, REFRIGERATED) FOR CLINICAL USE (Medical Device)\tpolysaccharide immune receptor activity (Molecular Function)\tShort distal phalanx of the 2nd toe (Anatomical Abnormality)\tAorto-ventricular junction (Body Location or Region)\tPhenmetrazine product (Appetite Depressants)", + "output": "polysaccharide immune receptor activity (Molecular Function)" + }, + { + "input": "Definition: Fusion protein described as a fusion protein encoded by the EML4/ALK fusion gene. This protein is comprised of the N-terminal portion of the echinoderm microtubule-associated protein-like 4 fused to the C-terminus of the ALK tyrosine kinase receptor protein including the entire cytoplasmic portion with the tyrosine kinase domain.\nConcepts: Republic of Djibouti (Geographic Area)\tHAMD-21 - Anxiety Somatic (HAMD 21 Questionnaire Question)\tEML4-ALK Fusion Protein (Fusion protein)\tcut-like 1 protein, human (TRANSCRIPTION FACTOR)\tLMM - Lentigo maligna melanoma (Cutaneous Melanoma)", + "output": "EML4-ALK Fusion Protein (Fusion protein)" + }, + { + "input": "Definition: Cell Function described as the process that results in the loss of attachments of a cell in the ventricular zone.\nConcepts: Unit of Volume Fraction (Quantitative Concept)\tRegulator of Calcineurin 1 Gene (Gene or Genome)\tdown-regulation of cell adhesion in ventricular zone (Cell Function)\t8: 143542379-143623370 (Spatial Concept)\tPolysaccharide Hydrolase (Hydrolase)", + "output": "down-regulation of cell adhesion in ventricular zone (Cell Function)" + }, + { + "input": "Definition: calcium salts described as the gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C336\" active clinical trials using this agent.\nConcepts: FIGO Stage IIA2 Cervical Carcinoma (Neoplastic Process)\tStudyProtocolDocumentVersionPublicTitle.typeCode (Type Code)\tCalcii gluconas (Replacement preparation)\tIFNG (Laboratory Procedure)\tSpherosome (Cell Component)", + "output": "Calcii gluconas (Replacement preparation)" + }, + { + "input": "Definition: something described as a measurement of the human leukocyte antigen A23 (HLA-A23) antibody in a biological specimen.\nConcepts: Anti-Thomsen-Friedenreich Antigen Antibody (Antibodies)\tparamyosin filament assembly or disassembly (actin cytoskeleton organization)\tup-regulation of FACT complex assembly (regulation of FACT complex assembly)\tHLA-A23 Antibody (Laboratory Procedure)\tGrade 1 Psychosis, CTCAE (Finding)", + "output": "HLA-A23 Antibody (Laboratory Procedure)" + }, + { + "input": "Definition: something described as a plant genus of Xanthorrhoeaceae.\nConcepts: X-ACT Autologous Lymph Node Lymphocytes (therapeutic autologous lymphocytes)\tBulbine (Plant)\tBHLHB24 (ID1 gene)\tIdeational Praxis: Stamp (Intellectual Product)\tmesonephric nephron morphogenesis (nephron morphogenesis)", + "output": "Bulbine (Plant)" + }, + { + "input": "Definition: something described as pediatric Outcomes Data Collection Instrument, Adolescent Parent-Reported Version (PODCI Adolescent Parent-Reported Version) If you answered \"sometimes\" or \"never or rarely\" to Question 66 above, was your child's activity limited by: General health?\nConcepts: APT1LG1 (Gene or Genome)\trenal vesicle morphogenesis (morphogenesis of an epithelium)\tNon-Protocol (Functional Concept)\tPODCI2-Gym Limited by: Health (Intellectual Product)\tUterine Corpus Adenosarcoma pN0 TNM Finding v8 (Finding)", + "output": "PODCI2-Gym Limited by: Health (Intellectual Product)" + }, + { + "input": "Definition: t-lymphotropic virus described as a lentivirus causing acquired immunodeficiency in cats. The FIV virus is transmitted in the saliva or blood, commonly through the bite wound from an infected cat. Strictly a feline disease, FIV cannot be transmitted to humans.\nConcepts: Abnormal level of phospholipids (Finding)\tFeline T-Lymphotropic Virus (Subfamily lentivirinae)\tPaced Tapping - Reciprocal Interval Self All (Paced Tapping Functional Test Question)\tVACUOLATION, EXTRACELLULAR (Finding)\tpeptide receptor activity (signaling receptor activity)", + "output": "Feline T-Lymphotropic Virus (Subfamily lentivirinae)" + }, + { + "input": "Definition: something described as the healthcare provider or setting must cooperate with audits of their activities conducted by the REMS program.\nConcepts: stem cell fate commitment (Cell Function)\tCloze Testing (Intellectual Product)\tCooperate with REMS Audits (Health Care Activity)\tFLJ16788 (NRK gene)\testhetic (Thesaurus of Psychological Index Terms)", + "output": "Cooperate with REMS Audits (Health Care Activity)" + }, + { + "input": "Definition: something described as an orally bioavailable inhibitor of histone deacetylase (HDAC) type 6 (HDAC6; HDAC-6), with potential antineoplastic activity. Upon administration, KA2507 targets, binds to and inhibits the activity of HDAC6. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. Specifically, inhibition of HDAC6 prevents STAT3 activity, which leads to a reduction in programmed death-1 (PD-1) expression. Eventually, this results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC6. HDAC6, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins.\nConcepts: HBP Gene (Gene or Genome)\tFAC100-Limit: Walking Up 5 Stairs (Intellectual Product)\tAnalysis, Dental Stress (Dentistry)\tHDAC6 Inhibitor KA2507 (Chemical Viewed Functionally)\tSYSTEM, DIALYSATE DELIVERY, RECIRCULATING (Medical Device)", + "output": "HDAC6 Inhibitor KA2507 (Chemical Viewed Functionally)" + }, + { + "input": "Definition: something described as a term that refers to the staging of small intestinal cancer according to the American Joint Committee on Cancer, 7th edition.\nConcepts: Delivery of Healthcare (health care delivery and administration)\ta (Body Space or Junction)\tTrisomy 18 (Disease or Syndrome)\tSmall Intestinal Carcinoma by AJCC v7 Stage (Neoplastic Process)\tTesticular Cancer Clinical TNM Finding v7 (Testicular Cancer TNM Finding v7)", + "output": "Small Intestinal Carcinoma by AJCC v7 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Immunologic Factor described as suppressor T-lymphocyte marker that functions as a receptor for MHC class I antigen.\nConcepts: CDISC SEND Pre-Clinical Units of Measure Terminology (Intellectual Product)\tUPDRS - Motor Examination: Tremor at Rest, Hands, Right (UPDRS Questionnaire Question)\tHLA - class 1 human leucocyte antigen receptor (Cell positive for CD8 antigen)\tDKK-4 (DKK4 gene)\tRadiology - speciality (medical specialty by technique)", + "output": "HLA - class 1 human leucocyte antigen receptor (Cell positive for CD8 antigen)" + }, + { + "input": "Definition: ATPase-coupled inorganic anion transmembrane transporter activity described as enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out).\nConcepts: RDQ0121 (RDQ Questionnaire Question)\tATP-dependent antimonite transporter activity (ATPase-coupled inorganic anion transmembrane transporter activity)\tquinone-dependent pyranose dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor)\tregulation of Ras protein signal transduction (Cell Function)\tintraconoid microtubule (Microtubules)", + "output": "ATP-dependent antimonite transporter activity (ATPase-coupled inorganic anion transmembrane transporter activity)" + }, + { + "input": "Definition: something described as tables and platforms designed to provide isolation and/or cancellation on their surface from floor vibrations. The devices are intended for use while performing tests using equipment that is sensitive to motion and vibration. These tables and platforms include one of a variety of passive or, less frequently, active isolation systems. Passive systems may include pneumatic, honeycomb or other type of isolators while active systems use semiconductors and are based on feedback techniques that may provide better vibration isolation or cancellation that is not possible with passive systems. Floor vibration tables and platforms are used for delicate measurements and/or in other delicate procedures such as those performed using microtomes, cell injection, and optical and electronic microscopy, including scanning tunnel and confocal laser scanning microscopy.\nConcepts: 131I-omburtamab (ANTINEOPLASTIC RADIOPHARMACEUTICALS)\tPROPOX (Laboratory Procedure)\tInpatient management not required (Finding)\tergothioneine catabolism (Molecular Function)\tFloor Vibration Isolation Tables (Table - furniture)", + "output": "Floor Vibration Isolation Tables (Table - furniture)" + }, + { + "input": "Definition: Virus described as a member of the herpes family of viruses.\nConcepts: Moderate oesophageal dysplasia (Esophageal dysplasia)\ttrehalose synthase activity (Molecular Function)\tMDS-UPDRS - Sleep Problems (Intellectual Product)\tHerpesviruses (Herpesvirales)\tCentral Stimulants (Stimulant)", + "output": "Herpesviruses (Herpesvirales)" + }, + { + "input": "Definition: Glycosaminoglycan [EPC] described as a drug used to relieve pain or discomfort associated with chronic inflammation of the bladder. It is also being evaluated for its protective effects on the gastrointestinal tract in people undergoing radiation therapy.\nConcepts: Ostomy Self-Care (Personal health management behavior)\tCharts, Flow (Document type)\tpentosan polysulphate (Direct acting anticoagulant)\tIK calcium-activated potassium channel activity (Molecular Function)\tProstaglandin Measurement (Fatty acid measurement)", + "output": "pentosan polysulphate (Direct acting anticoagulant)" + }, + { + "input": "Definition: TGFA Gene Product described as transforming growth factor alpha (50 aa, ~6 kDa) is encoded by the human TGFA gene. This protein is involved in both epidermal growth factor receptor signaling and the positive regulation of cell proliferation.\nConcepts: Specify Other Histologic Type (CPTAC Responses)\tTGF Type 1 (TGFA Gene Product)\tCoproporphyrinogens (Organic Chemical)\tlipid oxidation (Molecular Function)\tBiologic Markers (Thesaurus of Psychological Index Terms)", + "output": "TGF Type 1 (TGFA Gene Product)" + }, + { + "input": "Definition: something described as the determination of the amount of urea nitrogen present in a sample.\nConcepts: National Eye Institute Visual Functioning Questionnaire - 25 Version 2000 Interviewer-Administered Format Questionnaire Test Name (CDISC Questionnaire Terminology)\tUrea Nitrogen Measurement (Urine protein test)\terigeron canadense/fleabane (Pharmacologic Substance)\ttype i diabetes (ENDOCRINE FEATURES)\tregulation of T cell mediated immunity (regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains)", + "output": "Urea Nitrogen Measurement (Urine protein test)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a chromosomal abnormality consisting of the absence of a copy (homolog) of chromosome 13.\nConcepts: Monosomy 13 (Chromosome 13 Abnormality)\tnecrosis of abdominal soft tissue (Disease or Syndrome)\tLedum latifolium (Western herbs and natural substances letter L)\tsoluble NSF attachment protein activity (Molecular Function)\tLevosalbutamol (Ethanolamine and ethanolamine derivative-containing product)", + "output": "Monosomy 13 (Chromosome 13 Abnormality)" + }, + { + "input": "Definition: Cell Function described as the process in which a relatively unspecialized cell acquires specialized features of a mesenchymal stem cell that contributes to the shaping of a nephronin the mesonephros. A mesenchymal stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.\nConcepts: cyst; spinal meninges (Mass of body region)\tLaboratory studies (Laboratory Procedures)\tresponse to vitamin B6 (Cell Function)\tDCIS (Neoplasms, Ductal, Lobular, and Medullary)\tmesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis (Cell Function)", + "output": "mesenchymal stem cell differentiation involved in mesonephric nephron morphogenesis (Cell Function)" + }, + { + "input": "Definition: Therapeutic procedure described as providing experimental therapies to very sick individuals even though they don't meet the critera for inclusion in a trial.\nConcepts: Radiographic imaging procedure (Neuroimaging)\tCongenital or infantile constriction of pylorus (Gastrointestinal obstruction)\tLaryngeal Carcinoma Clinical Regional Lymph Nodes TNM Finding v8 (Finding)\tsepantronium bromide (Organic Chemical)\tTrial, Compassionate Use (Therapeutic procedure)", + "output": "Trial, Compassionate Use (Therapeutic procedure)" + }, + { + "input": "Definition: something described as cancer is found in the lining of the chest wall and the lymph nodes on the same side of the chest. Cancer may also be found in the lining of the lung, the lining of the diaphragm (the thin muscle below the lungs and heart that separates the chest from the abdomen), or the lining of the sac that covers the heart on the same side of the chest. Stage II malignant mesothelioma is advanced malignant mesothelioma.\nConcepts: up-regulation of monophenol oxygenase activity (positive regulation of monooxygenase activity)\tNasal Surgery Punches (Surgical punch)\tshikimate kinase II (Molecular Function)\tRADIOIMMUNOASSAY, GENTAMICIN (125-I), SECOND ANTIBODY SEP. (Indicator, Reagent, or Diagnostic Aid)\tStage II Mesothelioma of Pleura (Neoplastic Process)", + "output": "Stage II Mesothelioma of Pleura (Neoplastic Process)" + }, + { + "input": "Definition: Neurologic Oncology described as a branch of neurologic oncology that focuses on cancers in children.\nConcepts: ral A GTP-Binding Protein (Enzyme)\tPediatric neurology oncology (Pediatric neurology)\tHemoglobin Variant Measurement (Laboratory Procedure)\tAbnormal cellular physiology (Abnormality of metabolism/homeostasis)\tdorsal root ganglion development (Organ or Tissue Function)", + "output": "Pediatric neurology oncology (Pediatric neurology)" + }, + { + "input": "Definition: Vitamin D measurement described as the determination of the amount of Vitamin D3 present in a sample.\nConcepts: octanoyl transferase activity (Molecular Function)\tReceptors, Transferrin (Carrier Proteins)\tVitamin D3 Measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)\tRoniciclib (Pharmacologic Substance)\t3D1 CARLAVIRUS (BACTERIAL, INSECT, PLANT AND OTHER VIRUSES)", + "output": "Vitamin D3 Measurement (SPECIFIC SUBSTANCE CHEMISTRY TESTS)" + }, + { + "input": "Definition: General Body Topography described as the edge or border of the tissue removed in cancer surgery. The margin is described as negative or clean when the pathologist finds no cancer cells at the edge of the tissue, suggesting that all of the cancer has been removed. The margin is described as positive or involved when the pathologist finds cancer cells at the edge of the tissue, suggesting that all of the cancer has not been removed.\nConcepts: Diluters (Medical Device)\tAlkaline Phosphatase/Creatinine (Urine protein test)\tPDZK1 gene (Gene or Genome)\tlive freeze-dried lactic acid bacteria probiotic (Pharmacologic Substance)\tMargin of excision (Diagnostic or Prognostic Factor)", + "output": "Margin of excision (Diagnostic or Prognostic Factor)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as an NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. It plays a role in the degradation of VALINE; LEUCINE; and ISOLEUCINE.\nConcepts: 2-oxoisovalerate dehydrogenase (acylating) (Enzyme)\tALVAC(2) melanoma multi-antigen therapeutic vaccine (ALVAC vaccine)\tIVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation, SCNN1G (IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Mutation)\tSappey ligament (Body Part, Organ, or Organ Component)\tSDA (Laboratory Procedure)", + "output": "2-oxoisovalerate dehydrogenase (acylating) (Enzyme)" + }, + { + "input": "Definition: Scrophulariaceae described as a plant genus of the order Lamiales, family Linderniaceae.\nConcepts: IVD Test Reagent/Kits, Molecular Assay, Gene Anomaly, Deletion/Duplication, HTT (Medical Device)\tPlants, Resurrection (Scrophulariaceae)\tTOP3B protein, human (Amino Acid, Peptide, or Protein)\tt(11;19)(q23;p13.1) (Cell or Molecular Dysfunction)\tAccessory lacrimal glands set (Gland)", + "output": "Plants, Resurrection (Scrophulariaceae)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a fusion protein encoded by the TCF3/PBX1 fusion gene. This protein is comprised of the N-terminal transactivation domains of the transcription factor E2-alpha protein fused to the C-terminal DNA binding homeodomain of the pre-B-cell leukemia transcription factor 1 protein.\nConcepts: Neuropathy, distal hereditary motor, Jerash type (Distal Spinal Muscular Atrophy)\tretinoschises (Retinal Degeneration)\tanti-FAP/interleukin-2 fusion protein RO6874281 (Pharmacologic Substance)\tbiomagnetism measurement (Measurement)\tE2A-Pbx1 oncogene protein, fusion (Amino Acid, Peptide, or Protein)", + "output": "E2A-Pbx1 oncogene protein, fusion (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Medical Device described as an electrosurgical cutting and coagulation device and accessories is a device intended to remove tissue and control bleeding by use of high-frequency electrical current.\nConcepts: 19: 45483036-45431556 (Chromosome 19 Physical Location)\tInaccurate Delivery (Improper Flow or Infusion)\tRecurrent Renal Pelvis Urothelial Carcinoma (Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter)\tDEVICE, ELECTROSURGICAL, CUTTING & COAGULATION & ACCESSORIES (Medical Device)\tCylinder Valve (Valve Device)", + "output": "DEVICE, ELECTROSURGICAL, CUTTING & COAGULATION & ACCESSORIES (Medical Device)" + }, + { + "input": "Definition: Anthracycline Antibiotics described as a lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and repair as well as inhibiting RNA and protein synthesis. This agent appears to not be a substrate for the p-glycoprotein associated multidrug-resistance (MDR) transporter; therefore, overcoming the resistance pattern seen with other anthracycline compounds.\nConcepts: Renal papillary necrosis due to sickle cell disease (Kidney Papillary Necrosis)\tHomeobox Protein DLX-5 (Amino Acid, Peptide, or Protein)\tarea p24b' (area p24)\tAnnamycin (Pharmacologic Substance)\tnursing faculty (Nurses)", + "output": "Annamycin (Pharmacologic Substance)" + }, + { + "input": "Definition: Intellectual Product described as a diagnostic instrument for assessing DSM-IV syndromes in children aged 6 years or younger, administered as an interview for their caregivers.\nConcepts: Biopsy Guns, Side-Notch (Medical Device)\tTPRP Isoform Alpha (Amino Acid, Peptide, or Protein)\tOpening (Spatial Concept)\tlaryngeal oedema (Pathologic Function)\tDiagnostic Infant and Preschool Assessment (Research or Clinical Assessment Tool)", + "output": "Diagnostic Infant and Preschool Assessment (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Pharmacologic Substance described as electricity.\nConcepts: Electricity, Homeopathic preparation (Homeopathic remedies letter E)\tMesocarp (Plant)\tHAMD2-Suicide (HAMD 21 Questionnaire Question)\tErythrocytes sedimentation rate decreased (Haematological analyses NEC)\tup regulation of epithelial tube formation (regulation of epithelial tube formation)", + "output": "Electricity, Homeopathic preparation (Homeopathic remedies letter E)" + }, + { + "input": "Definition: Disorder of palate described as a neoplasm that affects the hard palate, soft palate, or uvula.\nConcepts: Level (Property or Attribute)\tSKB1 Homolog (S. pombe) Gene (Gene or Genome)\tTumor of Palate (Jaw Neoplasms)\tLow Risk HPV (Other Virus Grouping)\tapud cells (Neuroendocrine Cells)", + "output": "Tumor of Palate (Jaw Neoplasms)" + }, + { + "input": "Definition: Intellectual Product described as world Health Organization Disability Assessment Schedule 2.0 - 36-Item Proxy - I am the (Fill in the Blank) of this person.\nConcepts: TUBG2 (TUBG2 gene)\tpalmitoleic acid (Aliphatic carboxylic acid, C14-C26)\tWD6-I Am (Fill in Blank) of This Person (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)\tpositive regulation of branching involved in blood vessel morphogenesis (positive regulation of morphogenesis of an epithelium)\tReduced plasminogen activator inhibitor 1 antigen (Abnormality of fibrinolysis)", + "output": "WD6-I Am (Fill in Blank) of This Person (WHODAS 2.0 36-item Version Proxy-administered Questionnaire Question)" + }, + { + "input": "Definition: Special Histology Staining Method described as immunohistochemical or enzyme cytochemical staining method to detect myeloperoxidase, a lysosomal protein that has peroxidase enzyme activity and is present in granulocytic and monocytic cells, but absent in lymphocytes.\nConcepts: CDISC CDASH Concomitant Medication Dosing Frequency per Interval Terminology (Intellectual Product)\tR-Banding (Chromosome Banding)\tMyeloperoxidase stain (Special Histology Staining Method)\tChlamydia trachomatis (Busacca 1935) Rake 1957 (Approved Lists 1980) emend. Everett et al. 1999 (Chlamydia)\tFacilitated Oscillatory Release Treatment (Osteopathic manipulation)", + "output": "Myeloperoxidase stain (Special Histology Staining Method)" + }, + { + "input": "Definition: something described as a leukemia arising as a result of the mutagenic effect of chemotherapy agents that are used for the treatment of a malignant tumor or exposure to ionizing radiation.\nConcepts: ANTISERUM, FLUORESCENT, RUBEOLA (Indicator, Reagent, or Diagnostic Aid)\tCutis laxa (Dermal and epidermal conditions NEC)\tSU (Domain)\tTreatment Induced Leukemia (Treatment related secondary malignancy)\tnuclear migration along microfilament (nuclear migration)", + "output": "Treatment Induced Leukemia (Treatment related secondary malignancy)" + }, + { + "input": "Definition: Hereditary disorder of musculoskeletal system described as an extremely rare lethal form of chondrodysplasia with characteristics of severe micromelic dwarfism, short and incurved limbs with normal hands and feet, facial dysmorphism (disproportionately large skull, frontal prominence, slightly flattened nasal bridge and short neck), muscular hypotonia, hyperlaxity of the extremities, and a narrow thorax. Most patients die of respiratory distress during the first hours or weeks of life. There have been no further descriptions in the literature since 1988.\nConcepts: Maroteaux Stanescu Cousin syndrome (Hereditary disorder of musculoskeletal system)\tregulation of photorespiration (regulation of cellular metabolic process)\tMPAI1-Other Physical Cond-Pre-Injury (MPAI-4 Questionnaire Question)\tregulation of locomotion involved in locomotory behavior (regulation of behavior)\tStage IIIC Appendix Carcinoma AJCC v7 (Appendix Carcinoma by AJCC v7 Stage)", + "output": "Maroteaux Stanescu Cousin syndrome (Hereditary disorder of musculoskeletal system)" + }, + { + "input": "Definition: something described as catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide.\nConcepts: autologous PRAME-targeting T cell receptor-modified T cells MDG1011 (Cell)\t1-haloalkane halidohydrolase activity (Molecular Function)\tpositive regulation of Fcgamma receptor-mediated phagocytosis (regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)\tLow-Risk Human Papilloma Virus (Virus)\tIntralesional Injection (Injection of substance)", + "output": "1-haloalkane halidohydrolase activity (Molecular Function)" + }, + { + "input": "Definition: MED14 gene described as human MED14 wild-type allele is located within Xp11.4-p11.2 and is approximately 87 kb in length. This allele, which encodes mediator of RNA polymerase II transcription subunit 14 protein, is involved in transcriptional induction.\nConcepts: CXORF4 (Gene or Genome)\tIcebox, device (Household appliance)\tCystadenofibromas (Clear cell (mesonephroid) neoplasm - category)\tIllustration Graphic Art Publication and Audiovisual Service Shared Resource (Health Care Related Organization)\t5'-AMP-Activated Protein Kinase Catalytic Subunit Alpha-1 (Enzyme)", + "output": "CXORF4 (Gene or Genome)" + }, + { + "input": "Definition: Aplasia of the vermis described as rhombencephalosynapsis is a rare brain malformation defined by midline fusion of the cerebellar hemispheres with partial or complete loss of the intervening vermis.\nConcepts: Clostridium sordellii (Clostridium species q-z)\t16S rRNA (guanine(1516)-N(2))-methyltransferase activity (Genetic Function)\tMost or Almost All of the Time (Finding)\tRhombencephalosynapsis (Aplasia of the vermis)\tundef.misc.repro srvc narr r (Therapeutic or Preventive Procedure)", + "output": "Rhombencephalosynapsis (Aplasia of the vermis)" + }, + { + "input": "Definition: something described as a disorder characterized by an enduring pattern of inflexibility, extreme orderliness, and perfectionism which interfere with efficiency and which may manifest in many different contexts, including work and leisure activities, financial matters, and issues of morality or ethics.\nConcepts: Daughter Nuclides, Radon (Element, Ion, or Isotope)\tbacteriocins (Bacterial Toxins)\tacyl coenzyme A thioesterase activity (Molecular Function)\tpersonality disorder; anankastic (Obsessive-Compulsive Disorder)\tSimulators, Bone Sound Conduction, Mastoid (Medical Device)", + "output": "personality disorder; anankastic (Obsessive-Compulsive Disorder)" + }, + { + "input": "Definition: Biologically Active Substance described as a highly conserved complex comprised of small nuclear RNA and protein that plays a role in pre-rRNA processing in the nucleolus and both splicing and 3'-end processing of pre-mRNA in the nucleoplasm.\nConcepts: Vaccine Therapy (Therapeutic or Preventive Procedure)\th*ng/L (Quantitative Concept)\tIncidences (Morbidity - disease rate)\tSmall Nuclear Ribonucleoprotein (Ribonucleoproteins)\tCiliary Body Mixed Cell Melanoma (Neoplastic Process)", + "output": "Small Nuclear Ribonucleoprotein (Ribonucleoproteins)" + }, + { + "input": "Definition: Genetic Function described as catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon.\nConcepts: first spliceosomal transesterification activity (catalytic activity, acting on RNA)\tAbsent biceps (Aplasia of the musculature)\tFLJ20055 (MBTD1 gene)\tVacuolated Lymphocytes/Leukocytes (Blood Cell Count Ratio Measurement)\tcellular amide catabolic process (cellular nitrogen compound catabolic process)", + "output": "first spliceosomal transesterification activity (catalytic activity, acting on RNA)" + }, + { + "input": "Definition: Intellectual Product described as a set of models, implementation guides, controlled vocabularies, and exchange formats developed by the Clinical Data Interchange Standards Consortium (CDISC), which are intended to provide for consistent use of common representations of data, terms and specifications. NOTE: These standards apply to translational research, electronic submission of clinical data, and the life-cycle of clinical product development, which includes protocol representation, data collection, aggregation, tabulation, and analysis and unambiguous information exchange across disparate systems. [After https://www.ncbi.nlm.nih.gov]. See also standard, data standards, Study Data Standardization Plan, and Standards Development Organization.\nConcepts: CDISC Standard (Standard)\tStage II Bone Cancer AJCC v7 (Bone Cancer by AJCC v7 Stage)\tPea Protein (Amino Acid, Peptide, or Protein)\tMusculoskeletal Findings, Connective and Soft Tissue Findings Link Identifier (Intellectual Product)\tI just forget to take my medicines some of the time (Intellectual Product)", + "output": "CDISC Standard (Standard)" + }, + { + "input": "Definition: Odontogenic tumor, benign described as the most common odontogenic tumor, arising from the epithelial component of the embryonic tooth and usually affecting the molar-ramus region of the mandible or maxilla. Although most ameloblastomas are morphologically and clinically benign, they may cause extensive local destruction, recur, or metastasize.\nConcepts: Fish tapeworm (Eukaryote)\tAmeloblastoma NOS (Odontogenic tumor, benign)\tCone-shaped end part of the outermost bone of the index finger (Abnormality of the epiphysis of the distal phalanx of the 2nd finger)\tLeptospira (ORDER SPIROCHAETALES)\tHomosynaptic Depression (Organ or Tissue Function)", + "output": "Ameloblastoma NOS (Odontogenic tumor, benign)" + }, + { + "input": "Definition: Cell Function described as the process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth.\nConcepts: Maternal Death Level of Diagnostic Certainty (GAIA Obstetric Case Definitions)\tHDLCLDLC (LDL Cholesterol Lipoproteins)\tSpoken Word Recognition Deficit (Language Disorders)\tACHNAD (Changing)\tisotropic cell growth (Cell Function)", + "output": "isotropic cell growth (Cell Function)" + }, + { + "input": "Definition: urinary tract antibacterial agents described as a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para amino benzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.\nConcepts: Study Oversight Entity Type (Type - attribute)\tchild mental disorders (Developmental mental disorder)\tProduct containing sulfadiazine (Sulfonamides, ophthalmologic antiinfectives)\tDDMP (Pharmacologic Substance)\tEWI-F (Gene or Genome)", + "output": "Product containing sulfadiazine (Sulfonamides, ophthalmologic antiinfectives)" + }, + { + "input": "Definition: something described as this gene may play a role in transcriptional regulation.\nConcepts: CCND1 Gene Product (Biologically Active Substance)\tSarcomatous Glioma (Primary malignant neoplasm)\tNOCA-LIKE ZINC FINGER 1 (Transcription Regulation Gene)\tempowerment (Physical and psychosocial approaches)\tFatal (General Qualifier)", + "output": "NOCA-LIKE ZINC FINGER 1 (Transcription Regulation Gene)" + }, + { + "input": "Definition: RESPIRATORY SOUNDS, SIGNS AND MECHANISMS OF SOUND PRODUCTION described as crackles that are heard during the inspiratory phase.\nConcepts: RDQ - Try Not to Bend or Kneel (Intellectual Product)\tchemokine production (Organism Function)\tmilliliter/square cm (Quantitative Concept)\tinspiratory crackles (Lung)\tlung lobe formation (Organ or Tissue Function)", + "output": "inspiratory crackles (Lung)" + }, + { + "input": "Definition: St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question described as st. George's Respiratory Questionnaire Past 4 Weeks Version (SGRQ Past 4 Weeks Version) These are questions about what activities usually make you feel short of breath these days: Walking outside on level ground.\nConcepts: SGRQ02-Walking Outside on Level Ground (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)\tocclusal (General site descriptor)\tPUT1 (Oxidoreductase)\tEGFR inhibitor ABT-414 (Pharmacologic Substance)\tbeta-1,6 glucan biosynthesis (beta-glucan biosynthetic process)", + "output": "SGRQ02-Walking Outside on Level Ground (St George's Respiratory Questionnaire Past 4 Weeks Version Questionnaire Question)" + }, + { + "input": "Definition: Lisfranc ligament described as right Lisfranc ligament\nConcepts: BACS1-Number of Items Recalled Total (Intellectual Product)\t2-Pyrazinamine, 3-(3-(4-((Methylamino)methyl)phenyl)-5-isoxazolyl)-5-(4-((1-methylethyl)sulfonyl)phenyl)- (Antineoplastic Enzyme Inhibitor)\tRight Lisfranc ligament (Body Part, Organ, or Organ Component)\tHybrid Modeling (Research Activity)\tvistamycin synthesis (vistamycin metabolic process)", + "output": "Right Lisfranc ligament (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: something described as the directed movement of mitochondria to the correct region of the cell that contributes to the process of mitochondrial fission.\nConcepts: establishment of mitochondrion localisation involved in mitochondrial fission (establishment of mitochondrion localization)\tcibarial fish-trap bristle morphogenesis (Organ or Tissue Function)\tVirus, Transfusion-Transmitted (unclassified Anelloviridae)\tHEAVY CHAIN DIS (Malignant immunoproliferative disease)\tBacterial Adhesion (Organism Function)", + "output": "establishment of mitochondrion localisation involved in mitochondrial fission (establishment of mitochondrion localization)" + }, + { + "input": "Definition: something described as an ethacrynic acid derivative with diuretic activity.\nConcepts: RELATIVE (Family member)\tregulation of male mating behavior (Biologic Function)\tDryers, Lyophilization (Manufactured Object)\tAbnormal portal venous system morphology (Anatomical Abnormality)\tBrocrinat (Pharmacologic Substance)", + "output": "Brocrinat (Pharmacologic Substance)" + }, + { + "input": "Definition: Transient organic psychotic conditions described as a mental disorder caused by intrinsic disease which is characterized by persistent or recurrent irrational beliefs. Consciousness and memory are not affected. It may be broadly classified as a psychotic disorder due to a general medical condition.\nConcepts: Hermaphroditic Organisms (Organism Forms)\tdetection of stimulus involved in mitotic spindle checkpoint (detection of stimulus involved in mitotic cell cycle checkpoint)\t(90Y-DOTA(0),Tyr(3))octreotide (Biologically Active Substance)\tdisorder; organic, delusional (Other mental disorders due to brain damage and dysfunction and to physical disease)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation, t(11;14)(q13;q32) (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Translocation)", + "output": "disorder; organic, delusional (Other mental disorders due to brain damage and dysfunction and to physical disease)" + }, + { + "input": "Definition: deoxyribonucleotide catabolic process described as the chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.\nConcepts: Transfer of patient procedure (Hospitalization)\tpyrimidine deoxyribonucleotide catabolism (deoxyribonucleotide catabolic process)\tDobutamine Tartrate (Pharmacologic Substance)\tMicro-International Units per Milliliter per Microgram per Meter Squared per Day (Quantitative Concept)\tBody length (Length)", + "output": "pyrimidine deoxyribonucleotide catabolism (deoxyribonucleotide catabolic process)" + }, + { + "input": "Definition: Heavy metal screen described as the determination of the amount of gold present in a sample.\nConcepts: Trial Separation (Sexuality Related Social States and Problems)\tEnd Point (Qualitative Concept)\tgases (Physical State)\tINSTRUMENT, DOWEL CUTTING (Medical Device)\tGold (SPECIFIC DRUG AND TOXICOLOGY TESTS)", + "output": "Gold (SPECIFIC DRUG AND TOXICOLOGY TESTS)" + }, + { + "input": "Definition: IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question described as international Physical Activity Questionnaire (August 2002) Long Last 7 Days Self-Administered Format (IPAQ Long Last 7 Days Self-Administered Format Version) How much time did you usually spend on one of those days walking from place to place?: hours per day.\nConcepts: Study Personnel Primary Indicator (Qualitative Concept)\tIPA0313A (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)\tFAC01506 (Intellectual Product)\talpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide Phosphate(1:1) (Drug allergens)\tanti-CD20 monoclonal antibody-interferon alpha fusion protein IGN002 (Antineoplastic Antibody)", + "output": "IPA0313A (IPAQ Long Last 7 Days Self-Administered Format Version Questionnaire Question)" + }, + { + "input": "Definition: Angiogenesis Inhibitors described as any substance that inhibits vascular endothelial growth factor receptor, a family of tyrosine kinase receptors involved in the formation of blood vessels.\nConcepts: VEGFR tyrosine kinase inhibitor (Angiogenesis Inhibitors)\tAMY1 complex (Cell Component)\tDrug Finished Identifier (Identifier)\tTHORACOSCOPIC WEDGE RESECTION (Therapeutic or Preventive Procedure)\tregulation of aeciospore formation (regulation of asexual sporulation resulting in formation of a cellular spore)", + "output": "VEGFR tyrosine kinase inhibitor (Angiogenesis Inhibitors)" + }, + { + "input": "Definition: something described as a term that refers to the staging of penile cancer according to the American Joint Committee on Cancer, 8th edition. This staging system applies to penile squamous cell carcinoma and associated histologic subtypes. It does not apply to urethral carcinomas, sarcomas, and melanomas.\nConcepts: memory T cell activation (T-Cell Activation)\tWhole Body Low Dose Computed Tomography (X-Ray Computed Tomography)\tplastid to vacuole vesicle-mediated transport (vacuolar transport)\tFGF2 (FGF13 gene)\tPenile Cancer by AJCC v8 Stage (Neoplastic Process)", + "output": "Penile Cancer by AJCC v8 Stage (Neoplastic Process)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: UDP-glucose + a flavonol = UDP + a flavonol 3-O-D-glucoside.\nConcepts: HAQ0113 (HAQ-DI Questionnaire Question)\t13q14.2 (Chromosome band)\tAbnormality of ductus venosus blood flow (Finding)\tNEOPLASM (Intellectual Product)\tGTI (Molecular Function)", + "output": "GTI (Molecular Function)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in DNA unwinding and the promotion of DNA strand annealing.\nConcepts: sensory dendrite (Cell Component)\t17: 39556512-39509647 (Chromosome 17 Physical Location)\tRECQL1 (Gene or Genome)\tEscitalopram product (E [Preparations])\t3,5-Pyridinedicarboxylic acid, 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester (Antihypertensive Agents)", + "output": "RECQL1 (Gene or Genome)" + }, + { + "input": "Definition: Leiomyoma, Epithelioid described as an epithelioid cell type gastrointestinal stromal tumor with an indolent clinical course.\nConcepts: Dutogliptin Tartrate (Dipeptidyl Peptidase-4 Inhibitor)\tElaeagnaceae Juss., 1789 (Plant)\tLEIOMYOBLASTOMA, BENIGN (Leiomyoma, Epithelioid)\tJCHAIN wt Allele (Gene or Genome)\tBroad metatarsal (Finding)", + "output": "LEIOMYOBLASTOMA, BENIGN (Leiomyoma, Epithelioid)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating than an individual has or had mild dementia or depression.\nConcepts: sensory perception, sensory detection of thermal stimulus (Biologic Function)\tMild dementia or depression (Clinical or Research Assessment Answer)\tpicokatal (Quantitative Concept)\tvery long-chain fatty acid-CoA ligase activity (Molecular Function)\tSPN wt Allele (Gene or Genome)", + "output": "Mild dementia or depression (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Hemp family described as a plant genus in the CANNABACEAE family. Best known for the buds of Humulus lupulus L. used in BEER.\nConcepts: grooved pegboard test (Diagnostic Procedure)\tMPAI123 (MPAI-4 Questionnaire Question)\tCurcumin stain (Diarylheptanoids)\tHumulus, NOS (Hemp family)\tLA Grade D (Los Angeles Classification System)", + "output": "Humulus, NOS (Hemp family)" + }, + { + "input": "Definition: Bile Acids described as a bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.\nConcepts: PODCI2-Pour a Half Gallon of Milk (PODCI Adolescent Parent-Reported Version Questionnaire Question)\tRDQ0103 (RDQ Questionnaire Question)\tChenodeoxycholylglycine (chenodeoxycholic acid)\tlaryngomalacia (Degenerative disorder)\tNon-specified HCPCS II mobility equipment, device or accessory reference code no charge (Tracking code use with or without ICD diagnosis)", + "output": "Chenodeoxycholylglycine (chenodeoxycholic acid)" + }, + { + "input": "Definition: Gastrointestinal disorders NEC described as trauma to the gastrointestinal tract or accessory organs of digestions.\nConcepts: Downs syndrome (Hereditary Diseases)\tglutarate-semialdehyde dehydrogenase (NADP+) activity (Molecular Function)\tDC-OVA (Dendritic Cell Vaccine)\tInjury -gastrointestinal tract (Peritoneal and retroperitoneal disorders)\tKeratitis herpetic (Keratitis, Herpetic)", + "output": "Injury -gastrointestinal tract (Peritoneal and retroperitoneal disorders)" + }, + { + "input": "Definition: something described as any process that stops, prevents or reduces the frequency, rate or extent of amylopectin metabolic process.\nConcepts: Moderate Cardiac Valve Stenosis (Valvular stenosis)\tMasaoka Stage III (Thymoma by Masaoka-Koga Stage)\tnegative regulation of amylopectin metabolic process (regulation of amylopectin metabolic process)\tBendamustine/Obinutuzumab (Therapeutic or Preventive Procedure)\t(Coagulation defects) or (bleeding disorders) (Hemic and Lymphatic System)", + "output": "negative regulation of amylopectin metabolic process (regulation of amylopectin metabolic process)" + }, + { + "input": "Definition: something described as a non-taxonomic grouping of viruses that infect and lyse certain bacteria and archaea.\nConcepts: Iai (orbito-insular area)\tEPIC1-Problem Urgency of Bowel Movement (Intellectual Product)\tYip2e (Genes)\tbacterial virus (Virus)\tpositive regulation of oligopeptide transport (regulation of oligopeptide transport)", + "output": "bacterial virus (Virus)" + }, + { + "input": "Definition: something described as the third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.\nConcepts: Lymphatic (Qualitative Concept)\tlysophospholipid translocation (phospholipid translocation)\tGitter cell (Cell)\tSerous sac structure (Body Part, Organ, or Organ Component)\tSCF-YDR131C ubiquitin ligase complex location (SCF ubiquitin ligase complex)", + "output": "Gitter cell (Cell)" + }, + { + "input": "Definition: Cell Function described as a transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.\nConcepts: MET V1070E (Cell or Molecular Dysfunction)\tcardiac epithelial to mesenchymal transition (Cell Function)\tUnable to hear what was said even with a hearing aid (Finding)\tECG ACQUIRED WITH PRECORDIAL ELECTRODES PLACED ON RIGHT CHEST (Qualitative Concept)\tRecombinant Parathyroid Hormone-Related Protein (Recombinant Growth Factor)", + "output": "cardiac epithelial to mesenchymal transition (Cell Function)" + }, + { + "input": "Definition: something described as deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes.\nConcepts: Adenylyl Sulfate (Nucleic Acid, Nucleoside, or Nucleotide)\tCotton wool plaques (Acquired Abnormality)\tsargramostim plasmid DNA pancreatic tumor cell vaccine (Pharmacologic Substance)\tnegative regulation of IL-35 biosynthetic process (negative regulation of cytokine biosynthetic process)\tlight microscope (Microscopes)", + "output": "Cotton wool plaques (Acquired Abnormality)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O.\nConcepts: Treacle (TCOF1 gene)\t4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity (Molecular Function)\tGP (Gene or Genome)\tPacific Ocean (Geographic Area)\tAbnormality of the neck (Congenital Abnormality)", + "output": "4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity (Molecular Function)" + }, + { + "input": "Definition: Thesaurus of Psychological Index Terms described as the reciprocal interaction of two or more persons.\nConcepts: Interpersonal Relations (Psychology, Social)\tRight auricle wall (Anterior wall of right atrium)\tIVD Test Reagent/Kits, Molecular Assay, Immunology, Tissue Typing, Human Leukocyte Antigen, Class I, B Loci (Medical Device)\tTubing, Vinyl (Tubing, Synthetic Polymer)\tsurgery material/equipment (clinical biomedical equipment)", + "output": "Interpersonal Relations (Psychology, Social)" + }, + { + "input": "Definition: something described as human CFH wild-type allele is located in the vicinity of 1q32 and is approximately 96 kb in length. This allele, which encodes complement factor H protein, plays a role in the regulation of complement-mediated immunity. Mutation of the gene is associated with basal laminar drusen, complement factor H deficiency, hemolytic uremic syndrome atypical type 1, and age-related macular degeneration type 4.\nConcepts: EC (South America)\t44 PULMONARY ARTERIES (Thoracic Arteries)\tLamiales (Plant)\ttozuleristide (Pharmacologic Substance)\tHF1 (Gene or Genome)", + "output": "HF1 (Gene or Genome)" + }, + { + "input": "Definition: Molecular Function described as catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.\nConcepts: variability of individual responses (Thesaurus of Psychological Index Terms)\tSanfilippo Syndrome A (Disease or Syndrome)\tAnterior Pituitary Glycoprotein Hormones Common Alpha Subunit (G [Preparations])\t(R)-pantoate:beta-alanine ligase (Molecular Function)\tPerformedActivity.dateRange (Date Range)", + "output": "(R)-pantoate:beta-alanine ligase (Molecular Function)" + }, + { + "input": "Definition: Concept Attribute described as condition of the client in relation to objective and subjective defining characteristics\nConcepts: CDISC SEND Death Diagnosis Object of Measurement Terminology (Intellectual Product)\tIntra-aortic balloon pump [IABP] (Procedure on mediastinum)\tEndoribonucleases (Amino Acid, Peptide, or Protein)\tTurkmenistan (USSR)\tStatus (Qualitative Concept)", + "output": "Status (Qualitative Concept)" + }, + { + "input": "Definition: something described as any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport.\nConcepts: Image Display Error/Artifact (Display or Visual Feedback Problem)\tpositive regulation of DNA strand elongation (regulation of DNA strand elongation)\tKnowledge Engineering (Artificial Intelligence)\tpositive regulation of sodium-dependent phosphate transport (regulation of sodium-dependent phosphate transport)\tPrimary Mental Health Prevention (Treatment (General))", + "output": "positive regulation of sodium-dependent phosphate transport (regulation of sodium-dependent phosphate transport)" + }, + { + "input": "Definition: Topical Spray described as liquid preparation, usually multidose, consisting of an emulsion in a pressurized container with a spray valve or in a container equipped with a spray pump, intended for cutaneous use.\nConcepts: Distance Source to Detector (Quantitative Concept)\tTopical Emulsion Spray Dosage Form (Topical Spray)\tNCCN-FACT-FPSI 17 Version 2 - I Have Pain (Intellectual Product)\tHPV 16 E6 peptides vaccine/candida albicans extract (Immunologic Factor)\tGP130-RAPS (IL6ST gene)", + "output": "Topical Emulsion Spray Dosage Form (Topical Spray)" + }, + { + "input": "Definition: something described as the value of the current measurement minus the lowest value previously recorded.\nConcepts: Adults, Young (Age Group)\tACHNAD (Changing)\tAbsent leukocyte ALP (Finding)\tStem Cell, Pluripotent (Cell)\tgroin pains (Soft tissue disorders NEC in MDR)", + "output": "ACHNAD (Changing)" + }, + { + "input": "Definition: something described as records that describe the notification to investigators of all findings related to the safety of a clinical trial. This may contain important information on serious adverse events and/or safety concerns that could adversely affect the safety of subjects, impact the conduct of the trial, or alter the approval/favorable opinion of the institutional review board (IRB)/independent ethics committee (IEC) to continue the trial.\nConcepts: Zirconium Zr 89-DFO-REGN3504 (Indicator, Reagent, or Diagnostic Aid)\tage menarche (Adolescent Development)\tClinical Trial Notification to Investigators of Safety Information Document (Document type)\t6: 12398645-12404771 (Spatial Concept)\tKilogram per Square Centimeter (Quantitative Concept)", + "output": "Clinical Trial Notification to Investigators of Safety Information Document (Document type)" + }, + { + "input": "Definition: Central neurocytoma of brain described as a rare, WHO grade II cerebellar neoplasm which shows consistent neuronal, variable astrocytic and focal lipomatous differentiation. It occurs in adults, has a low proliferative potential and usually has a favorable prognosis.\nConcepts: Magnetic field (Natural Phenomenon or Process)\tArthropod Proteins (Amino Acid, Peptide, or Protein)\tcerebellar liponeurocytoma (Central neurocytoma of brain)\tMucor racemosus IgG Antibody RAST Score Measurement (Laboratory Procedure)\tCDRS117 (CDRS-R Clinical Classification Question)", + "output": "cerebellar liponeurocytoma (Central neurocytoma of brain)" + }, + { + "input": "Definition: something described as any bacterial species identified as Haemophilus haemolyticus that does not produce the enzyme beta-lactamase.\nConcepts: integrin alpha8-beta1 complex location (integrin complex)\tQS-FACT-LEU Version 4 TESTCD (CDISC Questionnaire Terminology)\tHaemophilus haemolyticus, Beta-Lactamase Negative (Bacterium)\tConnective-Tissue-Activating Peptide III (Immunologic Factor)\tLEGIONELLA PNEUMOPHILA SEROGROUP 7 (Legionella)", + "output": "Haemophilus haemolyticus, Beta-Lactamase Negative (Bacterium)" + }, + { + "input": "Definition: something described as a question about whether an individual is or was bothered by muscle stiffness.\nConcepts: invertebrate locomotion (Organism Function)\tN-ribosylpyrimidine nucleosidase activity (Molecular Function)\tPatent Foramen Ovale (Congenital abnormality of atrial septum)\tMuscle stiffness (Clinical or Research Assessment Question)\tmethylacetylene (CARBOXYLIC ACIDS AND SALTS)", + "output": "Muscle stiffness (Clinical or Research Assessment Question)" + }, + { + "input": "Definition: voltage-gated chloride channel activity described as enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane.\nConcepts: organellar voltage-dependent chloride channel activity (Molecular Function)\tLabd-13(16),14-diene-9-ol synthase activity (carbon-oxygen lyase activity, acting on phosphates)\td.mol/L/(kg/m2) (Quantitative Concept)\tlong-chain acyl coenzyme A hydrolase activity (acyl-CoA hydrolase activity)\tABT - Autologous blood transfusion (Therapeutic or Preventive Procedure)", + "output": "organellar voltage-dependent chloride channel activity (Molecular Function)" + }, + { + "input": "Definition: Respiratory signs and symptoms NEC described as discomfort felt in the upper abdomen, thorax, neck, or shoulders.\nConcepts: ROBO signaling pathway (cell surface receptor signaling pathway)\tiridocyclitis; hypopyon (examination of anterior chamber of eye)\tCordyceps / dong chong xiao cao (Plant)\tAbdominal cavity (Body cavities)\tthoracodynia (Ischaemic coronary artery disorders)", + "output": "thoracodynia (Ischaemic coronary artery disorders)" + }, + { + "input": "Definition: organic cyclic compound metabolic process described as the chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant.\nConcepts: 5: 126140732-126200608 (Spatial Concept)\tpg*h/mL/(mg/kg/day) (Measurement Unit Description)\tNon-specified HCPCS II wound care device, equipment or supply reference code no charge (Health Care Activity)\tRADIOLOGIST 1 (radiologist)\tvitamin E metabolic process (Molecular Function)", + "output": "vitamin E metabolic process (Molecular Function)" + }, + { + "input": "Definition: something described as a cytoarchitecturally defined term that refers to cerebral cortex in which the six layered composition is distinguished by a thick internal pyramidal layer (V) and external pyramidal layer (III) containing well developed pyramidal neurons ( Carpenter-1983 ).\nConcepts: Pharmaceutical Dosage Form (Intellectual Product)\tsqualene synthase activity (farnesyltranstransferase activity)\tOLAO (Health Care Related Organization)\ttype 2 of von Economo (Body Part, Organ, or Organ Component)\thutchinson-gilford syndrome (Laminopathies)", + "output": "type 2 of von Economo (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Regimen Used to Treat Acute Myeloid Leukemia described as a chemotherapy regimen consisting of cytarabine, daunorubicin, mercaptopurine, and prednisolone that may be used in the treatment of acute myeloid leukemia (AML).\nConcepts: FIBRINOGEN AND FIBRIN SPLIT PRODUCTS, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tAtypical Breast Papilloma (Intraductal papilloma of breast)\tDisease Has Molecular Abnormality (NCI Thesaurus Role)\tCytarabine-Daunorubicin-Mercaptopurine-Prednisolone (Regimen Used to Treat Acute Myeloid Leukemia)\tretinal cone cell fate determination (Cell Function)", + "output": "Cytarabine-Daunorubicin-Mercaptopurine-Prednisolone (Regimen Used to Treat Acute Myeloid Leukemia)" + }, + { + "input": "Definition: Tissue described as a single layer of specialized, flat, mitochondria-rich cells that line the posterior surface of the cornea, which govern fluid and solute transport across the posterior surface of the cornea.\nConcepts: Cancer Cell Growth (Neoplastic Cell Transformation)\tCorneal Endothelium (Body tissue)\tRegistry Protocol Identifier (Intellectual Product)\tWorst Severity Past Seven Days Acne or Pimples on the Face or Chest (Intellectual Product)\tNeoplasm of the inner ear (Abnormality of the inner ear)", + "output": "Corneal Endothelium (Body tissue)" + }, + { + "input": "Definition: Spatial Concept described as the stylized shape, of clover, having three or four leaves with or without the stem.\nConcepts: chloride methyl (M [Preparations])\tKeratins, Type II (Cytokeratin filaments)\tClover (Spatial Concept)\tGoniothalamus (Annonaceae)\tSulcus postpontinus (hindbrain)", + "output": "Clover (Spatial Concept)" + }, + { + "input": "Definition: Vagus Nerve Disorder described as a non-neoplastic or neoplastic disorder affecting the vagus nerve (tenth cranial nerve).\nConcepts: Prenatal doula services each 60 minutes (Prenatal care)\tVagus Nerve Disease (FUNCTIONS AND DYSFUNCTIONS OF THE CRANIAL NERVES)\tregulation of ATP:pyruvate 2-O-phosphotransferase activity (Molecular Function)\tLow serum 1,25-dihydroxycholecalciferol (Abnormality of vitamin D metabolism)\tMicronucleus - abnormality (Nuclear size alteration)", + "output": "Vagus Nerve Disease (FUNCTIONS AND DYSFUNCTIONS OF THE CRANIAL NERVES)" + }, + { + "input": "Definition: Lipid Metabolism described as the chemical reactions and pathways involving lipids, as carried out by individual cells.\nConcepts: PerformedProtocolDeviation.deviationCategoryCode (Intellectual Product)\tDefinedSubstanceAdministration.doseRegimen (Dose Regimen)\tMPO (Protein or Enzyme Type Measurement)\tcellular lipid metabolic process (Metabolic Process, Cellular)\tConsecutive esotropia (Esotropia)", + "output": "cellular lipid metabolic process (Metabolic Process, Cellular)" + }, + { + "input": "Definition: Musculoskeletal Diseases described as a subtype of a family of genetic disorders known as acrocephalopolysyndactyly (ACPS) disorders. It is a very rare disease; approximately 40 cases have been described in the literature. It is determined by acrocephaly, peculiar facies, brachydactyly and syndactyly in the hands, and preaxial polydactyly and syndactyly of the toes. Marked intrafamilial variability is possible. Inherited as an autosomal recessive trait.\nConcepts: Retinoblastoma pM1b TNM Finding v7 (Retinoblastoma Pathologic Distant Metastasis TNM Finding v7)\tAnalytical Balances (Balance, device)\tC14orf66 (DEGS2 gene)\tSMAC mimetic BI 891065 (Organic Chemical)\tAcrocephalopolysyndactyly type II (Acrocephalopolysyndactyly)", + "output": "Acrocephalopolysyndactyly type II (Acrocephalopolysyndactyly)" + }, + { + "input": "Definition: Intellectual Product described as negative Symptom Assessment-16 - Affect: Reduced modulation of intensity.\nConcepts: NSA01-Affect Reduce Modulation Intensity (Intellectual Product)\tDrug Dictionary (Intellectual Product)\tPolyps (Proliferation)\tmevaldate reductase (NAD+) activity (Molecular Function)\tpurine nucleotide binding (Molecular Function)", + "output": "NSA01-Affect Reduce Modulation Intensity (Intellectual Product)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid single-dose preparation with a gum-like consistency, intended to be sucked or chewed before being swallowed. Medicated chewing gum is excluded.\nConcepts: EUKARYOTIC TRANSLATION INITIATION FACTOR 5 (Translation Process Gene)\tOral gum (Chewing Gum)\tExtrapulmonary sequestrum (Bronchopulmonary Sequestration)\tPatient transfer to coronary care unit (Health Care Activity)\tup regulation of mesenchymal cell proliferation (Cell Function)", + "output": "Oral gum (Chewing Gum)" + }, + { + "input": "Definition: Geographic Locations described as a country in which a study takes or took place.\nConcepts: Study Country (Geographic Area)\tFilling, Powder, Nonsterile, Vibratory (Laboratory Procedure)\tRecurrent Cancer of the Rectum (Neoplastic Process)\tFamilial Adenomatous Polyposis Associated Medulloblastoma (Medulloblastoma)\tBortezomib/Liposomal Doxorubicin Regimen (Regimen Used to Treat Plasma Cell Myeloma)", + "output": "Study Country (Geographic Area)" + }, + { + "input": "Definition: Unusual skin infection described as a common, benign, usually self-limited viral infection of the skin and occasionally the conjunctivae by a poxvirus (MOLLUSCUM CONTAGIOSUM VIRUS).\nConcepts: Molluscum contagiosum infection (SECONDARY TERMS)\tMSUD Gene Panel Reagents (Medical Device)\tSubdivision of femoral artery (Non-coronary non-aorta systemic artery structure)\t(Hypothermia) or (Cryotherapy)\tAbnormality of endocrine pancreas physiology (Pathologic Function)", + "output": "Molluscum contagiosum infection (SECONDARY TERMS)" + }, + { + "input": "Definition: Benign neoplasm of lung described as a benign smooth muscle neoplasm arising from the lung. It is characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.\nConcepts: ubiquitin-dependent protein breakdown via the N-end rule pathway (proteasome-mediated ubiquitin-dependent protein catabolic process)\tLeiomyoma of Lung (Uterine Fibroids)\tSpeed of onset (Clinical course)\tHereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency (Congenital Disorders)\tmental disorder pharmacotherapy (Chemotherapy)", + "output": "Leiomyoma of Lung (Uterine Fibroids)" + }, + { + "input": "Definition: something described as functional Activities Questionnaire (FAQ) Preparing a balanced meal.\nConcepts: FAQ01-Preparing a Balanced Meal (Intellectual Product)\tGDP-mannose transmembrane transporter activity (purine nucleotide-sugar transmembrane transporter activity)\tEsophagus and Esophagogastric Junction Cancer Pathologic Distant Metastasis TNM Finding v8 (Esophagus and Esophagogastric Junction Cancer Pathologic TNM Finding v8)\tup-regulation of N-methyl-D-aspartate selective glutamate receptor activity (Cell Function)\tglycerol channel activity (channel activity)", + "output": "FAQ01-Preparing a Balanced Meal (Intellectual Product)" + }, + { + "input": "Definition: Extent described as an assessment of the amount, duration, and number of individuals affected by an exposure.\nConcepts: Strongly Agree (Agree)\tCD8 Positive (Laboratory or Test Result)\tExtent of Exposure (Quantitative Concept)\tC3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 7 (Amino Acid, Peptide, or Protein)\tinternet (Telecommunications)", + "output": "Extent of Exposure (Quantitative Concept)" + }, + { + "input": "Definition: Finding described as a finding about one or more characteristics of uterine corpus cancer, following the rules of the TNM AJCC v7 classification system. The TNM findings for uterine corpus carcinomas and sarcomas are not the same.\nConcepts: LOW CAD RISK (Quantitative Concept)\tallogeneic most closely HLA-matched adenovirus-specific cytotoxic T lymphocytes (Allogeneic Lymphocyte)\tUterine Corpus Cancer TNM Finding v7 (Finding)\tVery Severe Exertion (Intellectual Product)\tMICROSCOPE, SURGICAL, GENERAL & PLASTIC SURGERY (Medical Device)", + "output": "Uterine Corpus Cancer TNM Finding v7 (Finding)" + }, + { + "input": "Definition: Finding described as moderate symptoms; limiting instrumental ADL\nConcepts: miRNA-mediated inhibition of transcription by RNA polymerase II (negative regulation of transcription by RNA polymerase II)\tregulation of establishment or maintenance of bipolar cell polarity regulating cell shape (regulation of establishment or maintenance of bipolar cell polarity)\tHypoplasia of the thymus (Aplasia/Hypoplasia of the thymus)\tAbductor Hallucis Muscle (Abductor of metatarsophalangeal joint)\tGrade 2 Trochlear Nerve Disorder, CTCAE (Finding)", + "output": "Grade 2 Trochlear Nerve Disorder, CTCAE (Finding)" + }, + { + "input": "Definition: Clinical or Research Assessment Answer described as a response indicating that an individual is able to do something for the smallest amount of effort or duration of time.\nConcepts: CTL Differentiation Factor (Amino Acid, Peptide, or Protein)\trecombinant adenovirus-p53 SCH-58500 (Gene Therapy Agent)\tRADIOIMMUNOASSAY, DIGOXIN (125-I), RABBIT ANTIBODY, POLYETHYLENE GLYCOL (Indicator, Reagent, or Diagnostic Aid)\tCan Do Very Little (Clinical or Research Assessment Answer)\tpainful mouth (ORAL CAVITY AND ESOPHAGEAL FUNCTIONS)", + "output": "Can Do Very Little (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Finding described as symptomatic; medical intervention indicated (e.g., fat-restricted diet); paracentesis or tube drainage indicated\nConcepts: upregulation of macromitophagy (Cell Function)\tGrade 2 Chylous ascites (Chylous Ascites, CTCAE)\tBECKWITH-WIEDEMANN SYNDROME CHROMOSOME REGION 1, CANDIDATE A (Gene or Genome)\tMetaphase Spread (Laboratory Procedure)\tPDLIM4 Gene (Gene or Genome)", + "output": "Grade 2 Chylous ascites (Chylous Ascites, CTCAE)" + }, + { + "input": "Definition: Neoplasms described as a benign tumor of the parathyroid gland that can cause hyperparathyroidism.\nConcepts: RDOMAIN (Abbreviations)\tparathyroid adenoma (ENDOCRINE FEATURES)\tFalcivibrio vaginalis Hammann et al. 1984 (Bacterium)\tIVD Test Reagent/Kits, Serology, Virus, Rotavirus, Antigen (IVD Test Reagent/Kits, Serology, Virus)\tNational Coordinating Investigator (Professional or Occupational Group)", + "output": "parathyroid adenoma (ENDOCRINE FEATURES)" + }, + { + "input": "Definition: UHDRS 1999 Version Clinical Classification Question described as unified Huntington's Disease Rating Scale '99 - Disruptive or aggressive behavior: Frequency: Within the past month, how often have you had emotional or temper outbursts? How often have you had times when you lost control of yourself?\nConcepts: Thiamine Metabolism (Cofactors and Vitamins Metabolism Pathway)\tdrainage action (Clinical actions A - G)\t5q23-q31 (Cell Component)\tUHDRS 1999 Version - Disruptive Behavior: Frequency (UHDRS 1999 Version Clinical Classification Question)\tVoltage-Gated Sodium Ion Channel Activation (Phenomenon or Process)", + "output": "UHDRS 1999 Version - Disruptive Behavior: Frequency (UHDRS 1999 Version Clinical Classification Question)" + }, + { + "input": "Definition: TSCYC Questionnaire Question described as trauma Symptom Checklist for Young Children - Please indicate how often he or she has done, felt, or experienced each of the following things in the last month: Not wanting to talk about something that happened to him or her.\nConcepts: TSCYC1-Not Wanting to Talk (Intellectual Product)\tType I Hemipelvectomy (Therapeutic or Preventive Procedure)\tALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, CHROMOSOME 16-RELATED (Intellectual Disability)\tintracellular chloride channel activity (Molecular Function)\tnon-glycolytic fermentation (Molecular Function)", + "output": "TSCYC1-Not Wanting to Talk (Intellectual Product)" + }, + { + "input": "Definition: Gene or Genome described as this gene is involved in antigen processing by the proteasome.\nConcepts: Mineral Oil/Petrolatum-containing Eye Ointment (Pharmacologic Substance)\tleg disc anterior/posterior pattern formation (leg disc pattern formation)\tPROTEASOME SUBUNIT, BETA-TYPE, 10 (Peptidase Gene)\tOrder (Qualitative Concept)\talpha-ketoglutaric dehydrogenase activity (oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor)", + "output": "PROTEASOME SUBUNIT, BETA-TYPE, 10 (Peptidase Gene)" + }, + { + "input": "Definition: Intellectual Product described as a question about an individual's pain at its worst.\nConcepts: Your pain at its WORST (Findings-Based Question)\tmeiotic strand displacement involved in double-strand break repair via SDSA (meiotic strand displacement)\tBAD-BCL-2 complex (Cell Component)\tMAPKinase Signaling Pathway (Signal Transduction Pathways)\tchinese (Language)", + "output": "Your pain at its WORST (Findings-Based Question)" + }, + { + "input": "Definition: Cell Function described as a series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.\nConcepts: mitochondrial signaling pathway (Signal Transduction)\tGrade 4 Head Soft Tissue Necrosis, CTCAE (Head Soft Tissue Necrosis, CTCAE)\tGrade 4 Arteritis Infective, CTCAE (Finding)\tBenign Neoplasm of Glottis (Benign neoplasm of upper respiratory tract)\tgestational trophoblastic tumor, poor prognosis, metastatic (Gestational Trophoblastic Neoplasms)", + "output": "mitochondrial signaling pathway (Signal Transduction)" + }, + { + "input": "Definition: Finding described as the device fails to emit an audible alarm.\nConcepts: No Audible Alarm (Improper Alarm Medical Device Problem)\tAdult elemental anti-inflammatory GI intolerance critical care specialty formula (Adult critical care formula)\tSystem for Public Use (Manufactured Object)\tliver disorder chemotherapy (Therapeutic or Preventive Procedure)\tCYTOKERATINS (Medical Device)", + "output": "No Audible Alarm (Improper Alarm Medical Device Problem)" + }, + { + "input": "Definition: nucleoside triphosphate biosynthetic process described as the chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar.\nConcepts: QLES128B (Q-LES-Q Questionnaire Question)\tribonucleoside triphosphate biosynthetic process (nucleoside triphosphate biosynthetic process)\tDigitizers, Document (Medical Device)\t1-NITROSO-2-NAPHTHOL (FLUOROMETRIC), FREE TYROSINE (Indicator, Reagent, or Diagnostic Aid)\tLyophilisate for Emulsion for Injection (Solid Dose Form)", + "output": "ribonucleoside triphosphate biosynthetic process (nucleoside triphosphate biosynthetic process)" + }, + { + "input": "Definition: Organism Function described as the process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye.\nConcepts: Incubators (Medical Device)\tCN VI formation (cranial nerve formation)\twest virginia (Region of United States of America)\tEnvironmental Exposure (Environmental Health)\tregulation of auxin polar transport (regulation of hormone levels)", + "output": "CN VI formation (cranial nerve formation)" + }, + { + "input": "Definition: something described as a thymus-dependent nonapeptide found in normal blood. Stimulates the formation of E rosettes and is believed to be involved in T-cell differentiation.\nConcepts: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity (Molecular Function)\tTrial Visits Domain (Domain)\tE/A dx pkwd mtogn tst bloc e (Allergy testing)\tLEC0114F (LEC-5 Standard Version Questionnaire Question)\tSerum Factor, Thymic (Oligopeptides)", + "output": "Serum Factor, Thymic (Oligopeptides)" + }, + { + "input": "Definition: FGFR Family Alteration Negative described as a genetic finding indicating that FGFR2 gene mutations have not been detected in a sample.\nConcepts: immunophenotype (Immunologic Techniques)\tFGFR2 Wildtype (Laboratory or Test Result)\tKaurane (Diterpenes)\tanterior/posterior pattern specification involved in ureteric bud development (anterior/posterior pattern specification involved in kidney development)\tglucocorticoid-induced TNF-related ligand, human (Biologically Active Substance)", + "output": "FGFR2 Wildtype (Laboratory or Test Result)" + }, + { + "input": "Definition: Wrist Joint Implantable Prostheses described as implantable prostheses designed for total replacement of the wrist joint. These prostheses usually have two components: a radial component (consisting of two pieces, a flat metal device with a long stem at one end that anchors the prosthesis into the hollow center of the bottom of the radius and a very hard, slick plastic cup attached at the other end forming a socket for the wrist joint) and a distal component (consisting of two metal stems that are placed in the hollow bone marrow cavities of the carpal and metacarpal bones, respectively, with the opposite end shaped as a metallic ball that fits into the socket at the end of the radius). Both parts are metal; a high-density, tough, slick plastic (e.g., polyethylene) spacer between the two components enables the two components of the new joint to glide easily against each other, permitting movement of the wrist in all directions. Less frequently, a total prosthesis with a single across-the-joint component (usually made of a silicone elastomer) is used. Total wrist joint prostheses are used to stop bones from rubbing against each other; they may be used to restore wrist motion and/or strength in patients who suffer from osteoarthritis or rheumatoid arthritis, as well as after trauma (e.g., fracture).\nConcepts: Esophageal reflux (Abnormality of the stomach)\tTotal Wrist Prostheses (Medical Device)\tL5 vertebra (BONES OF VERTEBRAL COLUMN)\tNSPH (Hyperparathyroidism, Primary)\tPOUCH, COLOSTOMY (Stoma bag)", + "output": "Total Wrist Prostheses (Medical Device)" + }, + { + "input": "Definition: Description described as a comprehensive narrated account of a document.\nConcepts: Level 2a Assessment of Prematurity and Gestational Age (Intellectual Product)\t1,3-dichloro-2-propanol synthesis (Molecular Function)\tNeriums (Neriinae)\tDocument Detailed Description (Description)\tcost shared (Insurance)", + "output": "Document Detailed Description (Description)" + }, + { + "input": "Definition: Genetic Function described as any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III.\nConcepts: negative regulation of transcription by RNA polymerase III (negative regulation of transcription, DNA-templated)\tArizona Sexual Experiences Scale - Female Questionnaire Test Name (Intellectual Product)\tHydrocarbon (Organic Chemical)\tIVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Uniparental Disomy 14, Paternal (IVD Test Reagent/Kits, Molecular Assay, Chromosome Anomaly, Uniparental Disomy)\tProduct containing diazepam (Gamma-aminobutyric Acid (GABA) Augmenting Agents)", + "output": "negative regulation of transcription by RNA polymerase III (negative regulation of transcription, DNA-templated)" + }, + { + "input": "Definition: intracellularly ATP-gated ion channel activity described as enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane.\nConcepts: fibroadenoma breast (Benign neoplasm of thorax)\tATP-binding and phosphorylation-dependent chloride channel activity (chloride channel activity)\tNeonatal Bradyarrhythmia, Adverse Event (Finding)\tHuman Papilloma Virus-18 Positive (Human Papillomavirus Positive)\tneuron projection arborization (neuron projection morphogenesis)", + "output": "ATP-binding and phosphorylation-dependent chloride channel activity (chloride channel activity)" + }, + { + "input": "Definition: Mass of abdominal cavity structure described as cyst-like space not lined by EPITHELIUM and contained within the PANCREAS. Pancreatic pseudocysts account for most of the cystic collections in the pancreas and are often associated with chronic PANCREATITIS.\nConcepts: PANCREATIC PSEUDOCYST (Pancreatic Cyst)\tInflux Constant (Constant Data Value)\tBischloroethylsulfide (Hazardous or Poisonous Substance)\tcaspase complex (endopeptidase complex)\tnegative regulation of interleukin-18 biosynthetic process (Cell Function)", + "output": "PANCREATIC PSEUDOCYST (Pancreatic Cyst)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a change in the nucleotide sequence of the ERBB2 gene that either inhibits expression of the receptor tyrosine-protein kinase erbB-2 protein or results in the translation of an inactive receptor tyrosine-protein kinase erbB-2 protein.\nConcepts: metanephric nephron epithelium development (nephron epithelium development)\tFAC00604 (FACT-BL Version 4 Questionnaire Question)\tSmall Intestinal Anastomotic Leak, CTCAE (Finding)\tCoulometric Electrolyte Analyzers (Analyzers, Laboratory, Body Fluid, Electrolyte)\tHER-2 Inactivating Mutation (Cell or Molecular Dysfunction)", + "output": "HER-2 Inactivating Mutation (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as part of the ventral posterior nuclei of the thalamus, which relays sensory input from the body.\nConcepts: MAFG (MAFG gene)\tVentroposterior Lateral Nucleus of the Thalamus (Nucleus of brain)\tlymphocyte disorder CD4 t deficiency idiopathic (Disease or Syndrome)\tAJCCGRD (CDISC SDTM Terminology)\tpolarized epithelial cell differentiation (Cell Function)", + "output": "Ventroposterior Lateral Nucleus of the Thalamus (Nucleus of brain)" + }, + { + "input": "Definition: 5' Flank Mutation described as any mutation in a gene occurring in the 5' end which contains sequences which may regulate the transcription or translation of the message. 5' UTR mutations are found only outside of open-reading frames.\nConcepts: Ileus, GI (Adverse Event Associated with the Gastrointestinal System)\tMPAI1-Alcohol Use-Pre-Injury (MPAI-4 Questionnaire Question)\tMMS1-Repeat What I Say (Intellectual Product)\t5' UTR Mutation (5' Flank Mutation)\tblood vessel endothelial cell fate specification (endothelial cell fate specification)", + "output": "5' UTR Mutation (5' Flank Mutation)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in the formation of basement membrane collagen structures.\nConcepts: Mycobacterium bovis (Mycobacterium tuberculosis complex)\tParvorder (Classification)\tIncreased blood leukocyte number (WHITE CELL AND RES DISORDERS)\tReceptor Overall Status (Receptor status)\tCOLLAGEN OF BASEMENT MEMBRANE, ALPHA-2 CHAIN (Collagen Gene)", + "output": "COLLAGEN OF BASEMENT MEMBRANE, ALPHA-2 CHAIN (Collagen Gene)" + }, + { + "input": "Definition: something described as a family of naturally occurring polyketides that consist of C32 or C34 long chain fatty acids and combined with a propan-2-ol unit at C-2 to form a gamma-lactone, which are isolated from various species of the plant family Annonaceae, with potential antineoplastic and antimicrobial activity. Annonaceous acetogenins bind to the ubiquinone catalytic site(s) within the mitochondrial NADH:ubiquinone oxidoreductase (complex I), and block the electron transport chain in mitochondria. In addition, the acetogenins bind to and block the activity of ubiquinone-linked NADH oxidase, an enzyme overexpressed in the plasma membranes of cancer cells. This inhibits adenosine triphosphate (ATP) production, decreases intracellular ATP levels, and induces tumor cell apoptosis. Compared to normal cells, cancer cells have higher ATP demands. The Annonaceous acetogenins also inhibit microbial glucose dehydrogenase 6. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C118972\" active clinical trials using this agent.\nConcepts: pTX Cancer of the Bladder TNM Finding (Finding)\tNormal Bone Marrow Test Result (Normal Laboratory Test Result)\tCongenital megacalycosis (Caliectasis)\tElectrophoresis Systems, Capillary (Medical Device)\tAnnonaceous acetogenins (Antineoplastic Plant Product)", + "output": "Annonaceous acetogenins (Antineoplastic Plant Product)" + }, + { + "input": "Definition: Medical Device described as molecular assay reagents intended to identify Trypanosoma brucei, a species of flagellated protozoon, by detecting specific genetic information of the deoxyribonucleic acid (DNA) of the target parasite. These parasites are the etiologic agent of trypanosomosis (sleeping sickness) and Chagas' disease; they are transmitted via the bites of tsetse flies.\nConcepts: Long lashes (Finding)\tIVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Trypanosoma brucei, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Trypanosoma Species)\tSoft calvaria (Defect of skull ossification)\t2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\tdisorders skeletal (Arthropathy)", + "output": "IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Trypanosoma brucei, DNA (IVD Test Reagent/Kits, Molecular Assay, Infection, Parasite, Trypanosoma Species)" + }, + { + "input": "Definition: Structure of vein of upper extremity described as a large blood vessel which returns blood to the heart from the lateral thorax, axilla and upper limb. Each side of the body contains one axillary vein.\nConcepts: axillary veins (Axilla)\tregulation of methanofuran metabolism (Molecular Function)\tTransportation systems (Governmental or Regulatory Activity)\tregulation of filamentous growth of a population of unicellular organisms in response to neutral pH (Physiologic Function)\tFACIT-Dyspnea Scale 33 Item Bank Version - Limit: Carrying 5-10 Lbs (FACIT-Dyspnea Scale 33 Item Bank Version Questionnaire Question)", + "output": "axillary veins (Axilla)" + }, + { + "input": "Definition: Pharmacologic Substance described as a substance being studied in the treatment of cancer. It blocks proteins needed for cancer growth. It is a type of transcriptional inhibitor.\nConcepts: Terameprocol (DNA Groove Binding Agent)\tHAQ0142 (HAQ-DI Questionnaire Question)\tnewborns (Infant)\tSuperior vestibular nucleus (Entire vestibular nucleus)\tArtificial saliva agent (Medicinal product categorized by therapeutic role)", + "output": "Terameprocol (DNA Groove Binding Agent)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular described as immunoassay reagents intended to perform quantitative analyses on a body fluid sample (e.g., serum, plasma) to measure levels of digoxin (a cardiotonic glycoside that has positive inotropic and negative chronotropic activity and is used to control ventricular rate in atrial fibrillation as well as in the management of congestive heart failure) present in the sample. These reagents are used in tests intended to measure digoxin drug levels in patients undergoing treatment to determine the adequacy of digoxin dosages or to diagnose a drug overdose or drug-related toxicity.\nConcepts: Pace of thought (Mental Process)\tLipolyses (Biochemical Processes)\tIVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Digoxin (Medical Device)\tOABQ0102 (Intellectual Product)\tnot asked (Expanded yes/no indicator)", + "output": "IVD Test Reagent/Kits, Immunoassay, Therapeutic Drug, Cardiovascular, Digoxin (Medical Device)" + }, + { + "input": "Definition: Bacterium described as any bacterial organism that can be assigned to the species Prevotella buccalis.\nConcepts: Trimipramine maleate (Organic Chemical)\tbronchus circulation (Organ or Tissue Function)\tcytoskeleton-dependent intracellular transport (Intracellular Transport)\tHOXC13/NUP98 Fusion Gene (Fusion Gene)\tPrevotella buccalis (Bacterium)", + "output": "Prevotella buccalis (Bacterium)" + }, + { + "input": "Definition: something described as apolipoprotein L1 (398 aa, ~44 kDa) is encoded by the human APOL1 gene. This protein is involved in lipid transport and metabolism.\nConcepts: apolipoprotein L, human (Amino Acid, Peptide, or Protein)\ttelephone number type (DataType)\tactiveIngredientIndicator (Qualitative Concept)\tSevere adenovirus infection (Disease or Syndrome)\tConformations, Protein (Molecular Conformation)", + "output": "apolipoprotein L, human (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: something described as the chemical reactions and pathways involving any halogen, elements of Group VII; includes metabolism of halogen-containing compounds.\nConcepts: Anterior semilunar fibrous scallop of aortic valve anulus (Body Part, Organ, or Organ Component)\tleukocyte count (White blood cell test)\thalogen metabolism (Organism Function)\tprolactin induced protein (Ligand Binding Protein Gene)\tConventional release transdermal ointment (Biomedical or Dental Material)", + "output": "halogen metabolism (Organism Function)" + }, + { + "input": "Definition: Enteral+supplement feeds described as brand name of a nutritional supplement\nConcepts: Resource brand (Enteral+supplement feeds)\tGrade 3 Arterial injury (Finding)\tCerebellar falx (Brain part)\tNSAA117 (NSAA Clinical Classification Question)\tAdvanced Melanoma (Advanced cancer)", + "output": "Resource brand (Enteral+supplement feeds)" + }, + { + "input": "Definition: Chief complaint described as the latter part of the day and early part of the night; the period from sunset to bedtime.\nConcepts: bicyclogermacrene metabolic process (sesquiterpene metabolic process)\tBlue, Niagara (Diagnostic dye preparation used in the eye)\tChief Complaint Present in the Evening (Finding)\tSermons (Intellectual Product)\tFusion protein product (Amino Acid, Peptide, or Protein)", + "output": "Chief Complaint Present in the Evening (Finding)" + }, + { + "input": "Definition: Finding described as a pathologic finding about one or more characteristics of lip and oral cavity cancer, following the rules of the TNM AJCC v8 classification system as they pertain to staging of the primary tumor.\nConcepts: chenodeoxycholoyltaurine hydrolase activity (Molecular Function)\tConcentrated Solution Dosage Form Category (Biomedical or Dental Material)\tLobe of the Left Lung (Body Part, Organ, or Organ Component)\tLip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8 (Lip and Oral Cavity Cancer Pathologic TNM Finding v8)\tATTACHMENT, TEACHING, FOR ENDOSCOPE (Medical Device)", + "output": "Lip and Oral Cavity Cancer Pathologic Primary Tumor TNM Finding v8 (Lip and Oral Cavity Cancer Pathologic TNM Finding v8)" + }, + { + "input": "Definition: Body Space or Junction described as gonion is the most posterior inferior point on the outline of the angle of the mandible.\nConcepts: Central Nervous System Langerhans Cell Histiocytosis (Histiocytosis, Langerhans-Cell)\tprotein phosphatase 5 binding (protein phosphatase binding)\tButanoic acid, 2-(4-((4-chlorophenyl)methyl)phenoxy)-2-methyl-, ethyl ester, (+-)- (Organic Chemical)\tBETA-GLOBULIN, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)\tInferior angle point of mandible (Anatomical point)", + "output": "Inferior angle point of mandible (Anatomical point)" + }, + { + "input": "Definition: cellular protein modification process described as the protein modification process in which the translation-initiating methionine or formylmethionine residue is removed from a protein.\nConcepts: protein initiator methionine removal (Molecular Function)\tGoserelin Acetate Extended-release Microspheres (Luteinizing Hormone-releasing Hormone Agonist)\tVZTAUD (Quantitative Concept)\tselenate adenylyltransferase activity (Molecular Function)\tStaphylococcus cohnii subsp. urealyticus (Staphylococcus cohnii)", + "output": "protein initiator methionine removal (Molecular Function)" + }, + { + "input": "Definition: NPI Questionnaire Question described as neuropsychiatric Inventory - Frequency of the irritability/lability.\nConcepts: Laboratory Dialyzers (Laboratory instruments and equipment)\tNPI1-Irritability/Lability Frequency (NPI Questionnaire Question)\tHEARING-AID, BONE-CONDUCTION (Medical Device)\tGAGE6 (Gene or Genome)\tregulation of white fat cell proliferation (Cell Function)", + "output": "NPI1-Irritability/Lability Frequency (NPI Questionnaire Question)" + }, + { + "input": "Definition: something described as a malignant lymphoproliferative disorder that affects dogs. It is characterized by the clonal proliferation of B- or T-lymphocytes in the lymph nodes, bone marrow, and/or extranodal sites.\nConcepts: PARK7 Protein (Enzyme)\tOral Gavage Route of Administration (Drug Administration Routes)\tCanine Lymphoma (Disease or Syndrome)\tkaposi's lung sarcoma (Malignant neoplasm of lung)\tnegative regulation of macromolecule metabolic process (regulation of macromolecule metabolic process)", + "output": "Canine Lymphoma (Disease or Syndrome)" + }, + { + "input": "Definition: Biologically Active Substance described as programmed cell death protein 1 (288 aa, ~32 kDa) is encoded by the human PDCD1 gene. This protein is involved in the regulation of apoptosis.\nConcepts: Abdominal Binder (Medical Device)\tParatesticular Leiomyoma (Benign male reproductive tract neoplasm)\tprogrammed death protein 1, human (Apoptosis Regulatory Proteins)\tGD2-CAR-expressing Autologous Natural Killer T-Cells (Antineoplastic Immune Cell)\tdel(12q) (Cell or Molecular Dysfunction)", + "output": "programmed death protein 1, human (Apoptosis Regulatory Proteins)" + }, + { + "input": "Definition: Intellectual Product described as a FIGO stage term that applies to gynecologic cancers. There is no FIGO stage IIIC for cervical cancer; for endometrial cancer, FIGO stage IIIC is subdivided into stages IIIC1 and IIIC2; in FIGO stage IIIC1, there is regional metastasis to pelvic lymph nodes; for FIGO stage IIIC2, there is regional metastasis to para-aortic lymph nodes with or without metastasis to pelvic lymph nodes.\nConcepts: Ureteroscopes, Flexible (Medical Device)\tThyroid Cancer Pathologic TNM Finding v7 (Thyroid Cancer TNM Finding v7)\tSurface of groove for superior sagittal sinus (Body Location or Region)\tStage IIIC (Intellectual Product)\tpositive regulation by symbiont of ethylene levels in host (positive regulation by symbiont of hormone or growth regulator levels in host)", + "output": "Stage IIIC (Intellectual Product)" + }, + { + "input": "Definition: something described as single-bladder cuffs intended for a single-use (i.e., disposable) including an inflatable bladder and a standard (typically cylindrical or rectangular) shape that are designed to exert a pressure on the circumference of an extremity by means of a compressed gas delivered by a pneumatic tourniquet. These devices usually include one bladder within the cuff that is inflated through tubes (e.g., hoses) that run from the bladder connectors to the source of compressed air located in the control unit of the tourniquet. The cuff is fastened to the extremity using contact mechanisms (e.g., clips) and frequently secured with an external ribbon. Disposable single-bladder standard cuffs are usually supplied sterile in individual pouches for only one use and are not intended for sterilization processes at the healthcare facility; they are usually made of one integral unit with components (e.g., bladder) that cannot be replaced. The cuffs are used mainly during surgical procedures in the extremities using general anesthesia that need a completely sterile operating field. Disposable standard single-bladder cuffs are intended for use in specific extremity areas (e.g., arm, thigh, wrist, ankle) are available. Dedicated disposable non-standard cuffs with a smaller diameter distally than proximal when wrapped (i.e., contoured cuffs) are also available.\nConcepts: Cuffs, Pneumatic Tourniquet, Single Bladder, Standard, Disposable (Medical Device)\tRADIOIMMUNOASSAY, C-PEPTIDES OF PROINSULIN (Medical Device)\tDPP9 (Gene or Genome)\tADENOSINE A 02A RECEPTOR (Receptor)\tNuclear Factor E2-Related Factor 2 (Amino Acid, Peptide, or Protein)", + "output": "Cuffs, Pneumatic Tourniquet, Single Bladder, Standard, Disposable (Medical Device)" + }, + { + "input": "Definition: something described as a plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.\nConcepts: Rat Plasma Cell Myeloma (Rat Neoplasms by Morphology)\tX-linked intellectual disability Pai type (Mental Retardation)\tHLA-A*2402-restricted KOC1-TTK-CO16-DEPDC1-MPHOSPH1 multipeptide vaccine (Pharmacologic Substance)\tmalig neoplasm tnm staging primary tumor (t) t2b (Finding)\tFlaxseed (Linaceae)", + "output": "Flaxseed (Linaceae)" + }, + { + "input": "Definition: Body Part, Organ, or Organ Component described as a subdivision of the thalamus. It, the Nucleus zentrolateralis caudalis internus (Hassler) and the Nucleus ventrocaudalis anterior externus (Hassler) constitute the caudal part of the ventral posterolateral nucleus ( Macchi-1997 ).\nConcepts: EGFR Gene Alteration Positive (Laboratory or Test Result)\t5fC dioxygenase (Molecular Function)\tbenzene catabolism (Molecular Function)\tIgG immunoglobulin complex location (Cell Component)\tNucleus zentrolateralis caudalis externus (Body Part, Organ, or Organ Component)", + "output": "Nucleus zentrolateralis caudalis externus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Fungal eye infections described as keratitis caused by fungi.\nConcepts: chiles (Geographic Area)\tFungal Keratitis (Keratitis caused by infection)\tPostmastectomy extremity angiosarcoma (Lymphangioma)\tLinear Accelerator Radiotherapy System Software (Intellectual Product)\tSevere varicella zoster infection (Disease or Syndrome)", + "output": "Fungal Keratitis (Keratitis caused by infection)" + }, + { + "input": "Definition: General finding of soft tissue described as fasciculations or fibrillation affecting the tongue muscle.\nConcepts: zibotentan (Organic Chemical)\tInfection by Microsporidia (Protozoan Infections)\tNon-Citizen National (Persons)\tTongue Fasciculation (Motor function of tongue)\tmaintenance of alignment of postsynaptic density and presynaptic active zone (maintenance of synapse structure)", + "output": "Tongue Fasciculation (Motor function of tongue)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in immune function and mediates T-cell responses.\nConcepts: Sexual preference, NOS (Detail of sexuality and sexual activity)\tHLA Class IC Antigen (Immunologic Tests)\tINTERLEUKIN RECEPTOR, GAMMA-C (Cytokine Receptor Gene)\tAntisense Technology (Molecular Biology Research Technique)\tAsthma Nighttime Symptom Diary v1.0 Questionnaire Test Name (Intellectual Product)", + "output": "INTERLEUKIN RECEPTOR, GAMMA-C (Cytokine Receptor Gene)" + }, + { + "input": "Definition: PPP6C gene described as human PPP6C wild-type allele is located in the vicinity of 9q33.3 and is approximately 43 kb in length. This allele, which encodes serine/threonine-protein phosphatase 6 catalytic subunit protein, is involved in protein dephosphorylation, signal transduction and cell cycle regulation.\nConcepts: E-407 HISTOPLASMOSIS (Infection)\tCALNA3 (PPP3CC gene)\tregulations (Document type)\tnegative regulation of mating-type specific transcription, DNA-dependent (regulation of mating-type specific transcription, DNA-templated)\tPPP6C wt Allele (PPP6C gene)", + "output": "PPP6C wt Allele (PPP6C gene)" + }, + { + "input": "Definition: something described as using counseling techniques to assist a client in identifying and managing compulsive religious behavior and to initiate religious balance in his or her life. Service is billed in 15-minute increments.\nConcepts: Religious Addiction Prevention (Therapeutic or Preventive Procedure)\tGrade 2 Pancreatic anastomotic leak (Pancreatic Anastomotic Leak, CTCAE)\tHypersplenism syndrome (Spleen)\tSol (Nucleus of brain)\tFirst Use Syndrome (Disease or Syndrome)", + "output": "Religious Addiction Prevention (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: Ocular Physiological Phenomena described as processes and properties of the EYE as a whole or of any of its parts.\nConcepts: JAK2 Gene Variant (JAK Family Gene Mutation)\teye functions (Czech translation of the Medical Subject Headings)\tNP (Advanced Practice Nurse)\tDiktyoma (Embryonal neuroepithelial tumor)\tAblation, Catheter (Therapeutic or Preventive Procedure)", + "output": "eye functions (Czech translation of the Medical Subject Headings)" + }, + { + "input": "Definition: establishment of protein localization to membrane described as the directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.\nConcepts: SEPARATOR, AUTOMATED, BLOOD CELL, DIAGNOSTIC (Medical Device)\tprotein translocation into membrane raft (establishment of protein localization to membrane)\tSpontaneously Regressing Retinoblastoma (Neoplasms, Neuroepithelial)\tTracheal Cleft (Congenital Abnormality)\tJR 6 (Medical Device)", + "output": "protein translocation into membrane raft (establishment of protein localization to membrane)" + }, + { + "input": "Definition: Intellectual Product described as a rating scale included in the Behavior Rating Inventory of Executive Function that assesses work-checking habits and interpersonal awareness. The task monitoring portion of the scale captures whether a child assesses his or her own performance during or shortly after finishing a task to ensure accuracy or appropriate attainment of a goal. The self-monitoring portion of the scale evaluates whether a child keeps track of the effect that his or her behavior has on others.\nConcepts: myotube cell development involved in skeletal muscle regeneration (Cell Function)\tBiopsy Punches (Biopsy Instruments)\tVial, Dispensing (Manufactured Object)\tMonitor Scale (Research or Clinical Assessment Tool)\tRNA-Binding Protein EWS/Transcription Factor Sp3 Fusion Protein (Amino Acid, Peptide, or Protein)", + "output": "Monitor Scale (Research or Clinical Assessment Tool)" + }, + { + "input": "Definition: Congenital vascular anomaly of eye described as an abnormal connection between arteries and veins, occurring within the retinal vasculature, which can result in visual changes, and blindness.\nConcepts: Musculus flexor hallucis brevis (Foot)\tCongenital arteriovenous malformation of retina (Congenital vascular anomaly of eye)\tCognitive Aging (Aging)\tWarming Units, Microscope Slide (In Vitro Diagnostics and Laboratory Equipment)\tcarotid internal artery (Internal carotid artery and its branches)", + "output": "Congenital arteriovenous malformation of retina (Congenital vascular anomaly of eye)" + }, + { + "input": "Definition: Intellectual Product described as a response indicating that an individual has been somewhat more socially active than before.\nConcepts: SCF Ubiquitin Ligase (Enzyme)\tSomewhat more socially active as before (Clinical or Research Assessment Answer)\tCRSR01-Visual Function Scale (Intellectual Product)\tUndifferentiated Carcinoma of Gallbladder (Gallbladder Carcinoma)\tPoly(A)-Binding Protein II (Biologically Active Substance)", + "output": "Somewhat more socially active as before (Clinical or Research Assessment Answer)" + }, + { + "input": "Definition: Genes described as this gene is involved in DNA replication and repair.\nConcepts: TYMS (Genes)\tDehydration Polycythemia (Secondary polycythemia)\tOsteosclerotic Lesion (Finding)\tMNSI105 (MNSI Questionnaire Question)\tterrorism (Criminal Offenses)", + "output": "TYMS (Genes)" + }, + { + "input": "Definition: Anti-Infective Agents described as permanganate of potassium.\nConcepts: potassium permanganate (permanganic acid)\tUDPglucose:sinapic acid glucosyltransferase activity (Molecular Function)\tadenine nucleotide transmembrane transporter activity (Molecular Function)\tCDC48 protein, human (Esterases)\tprotein localisation to horsetail-astral microtubule array (protein localization to cortical microtubule cytoskeleton)", + "output": "potassium permanganate (permanganic acid)" + }, + { + "input": "Definition: Primary malignant neoplasm described as a very rare, locally aggressive, malignant neoplasm of the hair follicle. The majority of the cases arise de novo, however malignant transformation from a pre-existing pilomatricoma has been reported. It usually presents as a solitary nodule in the head and neck, upper extremities, or buttocks. Morphologically, it is characterized by the presence of aggregates of basaloid cells infiltrating the dermis. Masses of ghost cells are present in the cellular aggregates. Complete surgical excision is the treatment of choice. If it is not completely removed, it usually recurs, but it rarely metastasizes to distant anatomic sites.\nConcepts: Standard Toxicity Grade 4 (Adverse Event by CTCAE v3 Severity Grade)\tMalignant pilomatrixoma (Carcinoma, Skin Appendage)\tMURF2 (Gene or Genome)\tElement, Genetic Enhancer (Nucleic Acid, Nucleoside, or Nucleotide)\tHypermobility of interphalangeal joints (Anatomical Abnormality)", + "output": "Malignant pilomatrixoma (Carcinoma, Skin Appendage)" + }, + { + "input": "Definition: something described as any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: Sterilization Packaging (Diagnostic, Therapeutic, and Research Equipment)\tNevus of Female Genitalia (Neoplastic Process)\tpositive regulation of glucose transmembrane transport (regulation of glucose transmembrane transport)\tblood pressure regulation by capillary fluid shift (Organism Function)\tIntrahepatic Choledochal Cysts (Congenital Abnormality)", + "output": "positive regulation of glucose transmembrane transport (regulation of glucose transmembrane transport)" + }, + { + "input": "Definition: something described as an infection of the lung caused by environmental mycobacteria. Such infections can occur in individuals with predisposing lung disease or immune disease.\nConcepts: Absent distal interphalangeal creases (Hand)\tARE (Response Elements)\tNeuroendocrine Carcinoma of the Skin cN0 TNM Finding v8 (Finding)\tanimals models (Investigative Techniques)\tNontuberculous mycobacterial pulmonary infection (Opportunistic bacterial infection)", + "output": "Nontuberculous mycobacterial pulmonary infection (Opportunistic bacterial infection)" + }, + { + "input": "Definition: something described as pediatric Quality of Life Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults (PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults) In the past 7 days, how much of a problem has this been for your child: It is hard for my child to ask the doctors and nurses questions.\nConcepts: NASAL CAVITY (Respiratory region of nose)\tPedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults - Hard Ask Doctors and Nurses Questions (Intellectual Product)\ttRNA-intron endonuclease complex location (Cell Component)\tHIL (Language)\tIllness Behavior (Behavior)", + "output": "PedsQL Neuromuscular Module Acute Version 3.0 Parent Report for Young Adults - Hard Ask Doctors and Nurses Questions (Intellectual Product)" + }, + { + "input": "Definition: Cell or Molecular Dysfunction described as a cytogenic abnormality that refers to loss of all or part of chromosome 5.\nConcepts: AVL01-List A Recall 1 Word 8 (ADNI-AVLT Questionnaire Question)\t-5 (Cell or Molecular Dysfunction)\tMalignant Mixed Tumor of the Major Salivary Gland (Neoplastic Process)\tcarboxyspermidine dehydrogenase II activity (oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor)\tParasellar Cistern (Body Part, Organ, or Organ Component)", + "output": "-5 (Cell or Molecular Dysfunction)" + }, + { + "input": "Definition: Oriental herbs and natural substances letter S described as wu wei zi\nConcepts: ADL0113 (ADCS-ADL Questionnaire Question)\tWu wei zi (Plant)\tpeptidyl-cysteine acetylation (peptidyl-cysteine modification)\tHypokalemia (Finding)\tautologous bone marrow transplantation (Therapeutic or Preventive Procedure)", + "output": "Wu wei zi (Plant)" + }, + { + "input": "Definition: Antibiotics described as semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections.\nConcepts: Roxithromycine (Antibiotics)\tPast Seven Days Decreased Appetite Interfering with Usual or Daily Activities (Findings-Based Question)\tachromobactin degradation (carboxylic acid catabolic process)\tDrug Combination, Emtricitabine-Rilpivirine-Tenofovir (Pharmacologic Substance)\tregulation of apolipoprotein binding (Molecular Function)", + "output": "Roxithromycine (Antibiotics)" + }, + { + "input": "Definition: Form family Cryptococcaceae described as any fungal organism that can be assigned to the species Guehomyces pullulans.\nConcepts: FAC008-FACT-G Total Score (FACT-C Version 4 Questionnaire Question)\tup regulation of glucocorticoid metabolic process (Molecular Function)\tBone structure shaft of ulna (Part of diaphysis of bone)\tOospora pullulans (Form family Cryptococcaceae)\tWound irrigation (Common nursing interventions II)", + "output": "Oospora pullulans (Form family Cryptococcaceae)" + }, + { + "input": "Definition: Abnormal inferior vena cava morphology described as interrupted inferior vena cava with azygous continuation is the result of connection failure between the right subcardinal vein and the right vitelline vein. Consequently, venous blood from the caudal part of the body reaches the heart via the azygous vein and superior vena cava.\nConcepts: Interrupted inferior vena cava with azygous continuation (Abnormal inferior vena cava morphology)\tadministrative information regarding test substance egg protein (egg)\tLights, Surgical, Wall-Mounted, Single-Head (Lights, Surgical, Wall-Mounted)\t2 Aminonaphthalene (Carcinogenic Aromatic Amine)\tCD314 (Gene or Genome)", + "output": "Interrupted inferior vena cava with azygous continuation (Abnormal inferior vena cava morphology)" + }, + { + "input": "Definition: something described as best corrected visual acuity of 20/200 or worse in the affected eye\nConcepts: Muscle Tension (Musculoskeletal Physiological Phenomena)\tendoderm development (Organ or Tissue Function)\tGrade 4 Vision Decreased, CTCAE (Vision Decreased, CTCAE)\ttungsten incorporation into metallo-sulphur cluster (Molecular Function)\tFactors, Transforming Growth (Amino Acid, Peptide, or Protein)", + "output": "Grade 4 Vision Decreased, CTCAE (Vision Decreased, CTCAE)" + }, + { + "input": "Definition: sulfur compound binding described as interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.\nConcepts: Sulfate, Dermatan (Biologically Active Substance)\taneurine pyrophosphate binding (Molecular Function)\tType II alveolar cell (Cell)\tApocrine sweat gland structure (Sweat Glands)\tOrgan Measurements Biospecimen Usability (Biospecimen Usability)", + "output": "aneurine pyrophosphate binding (Molecular Function)" + }, + { + "input": "Definition: Gastrointestinal Absorption described as uptake of substances from the RECTUM.\nConcepts: Aryepiglottic Folds (Structure of half of head lateral to midsagittal plane)\tAnonychia of toenails (Aplastic/hypoplastic toenail)\tBladder Tumor Antigen Stat (Laboratory Procedure)\tAbsorption, Rectal (Gastrointestinal Absorption)\tCryosurgery - action (Operative Surgical Procedures)", + "output": "Absorption, Rectal (Gastrointestinal Absorption)" + }, + { + "input": "Definition: Intellectual Product described as test names of clinical classification questions associated with the Covi Anxiety Scale (COVI) for the Clinical Data Interchange Standards Consortium (CDISC) Study Data Tabulation Model (SDTM).\nConcepts: Emergency Power Failure (Electrical Power Problem)\tClinical Preventive Practices (Lifestyle and Disease Prevention)\tRNA, Ribosomal, 5S (Nucleic Acid, Nucleoside, or Nucleotide)\tCovi Anxiety Scale Clinical Classification Test Name (CDISC Clinical Classification Terminology)\tstage IIIA cervical cancer (Neoplastic Process)", + "output": "Covi Anxiety Scale Clinical Classification Test Name (CDISC Clinical Classification Terminology)" + }, + { + "input": "Definition: Raised biochemistry finding described as a laboratory test indicating increased levels of amylase in the serum.\nConcepts: Lewis blood group system (Classification)\tmetabolic tests serum amylase increased (Abnormal circulating amylase level)\t-FPI-1434 (Immunologic Factor)\tCOMPARATIVE ANAT (Science of Anatomy)\tHypotensive technique (Anesthesia and Analgesia)", + "output": "metabolic tests serum amylase increased (Abnormal circulating amylase level)" + }, + { + "input": "Definition: something described as an alveolar soft part sarcoma which has spread to another anatomic site.\nConcepts: INFECT OXYURIDA (Secernentea Infections)\tEruption, Tooth (Physiological Processes)\tAlveolar Soft Part Sarcoma Metastatic (Alveolar Soft Part Sarcoma)\tMAOB Gene (Gene or Genome)\tEGFR NM 005228.3:c.2239 2247delTTAAGAGAA (Cell or Molecular Dysfunction)", + "output": "Alveolar Soft Part Sarcoma Metastatic (Alveolar Soft Part Sarcoma)" + }, + { + "input": "Definition: Nasal Cavity and Paranasal Sinuses Cancer pN2 TNM Finding v8 described as nasal cavity and paranasal sinuses cancer with metastases in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension and ENE(-).\nConcepts: Exocrine Pancreatic Carcinoma Clinical Distant Metastasis TNM Finding v8 (Finding)\tCefradine product (Antibiotic)\tnegative regulation of cellulose catabolic process (regulation of cellulose catabolic process)\tNasal Cavity and Paranasal Sinuses Cancer pN2c TNM Finding v8 (Finding)\tmonosaccharide binding (small molecule binding)", + "output": "Nasal Cavity and Paranasal Sinuses Cancer pN2c TNM Finding v8 (Finding)" + }, + { + "input": "Definition: Hodgkin's disease nodular sclerosis type described as ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE).\nConcepts: Stage I Small Cell Lung Carcinoma (Lung Small Cell Carcinoma by AJCC v7 Stage)\tSSDI (Population Database)\tGeneralized onset epileptic spasm (Disease or Syndrome)\tNodular Sclerosis Hodgkin's Disease Stage II (Hodgkin's disease nodular sclerosis type)\tF and A (Financial cost)", + "output": "Nodular Sclerosis Hodgkin's Disease Stage II (Hodgkin's disease nodular sclerosis type)" + }, + { + "input": "Definition: Conceptual Entity described as an indication as to whether there is a prolapsing cardiac valve cusp.\nConcepts: intracellular skeleton (intracellular non-membrane-bounded organelle)\tCusp Prolapse Indicator (Indicator)\tglucuronoxylan 4-O-methyltransferase activity (Molecular Function)\tAbsent/small diaprhagm (Abnormality of the diaphragm)\tRap protein signal transduction (Ras protein signal transduction)", + "output": "Cusp Prolapse Indicator (Indicator)" + }, + { + "input": "Definition: Intellectual Product described as an integer specifying the relative sequential or temporal ordering of this relationship among other similar relationships having the same source.\nConcepts: sexual dysfunction (Sexual Dysfunction and Infertility)\tPARTNER-DDS - Hypoglycemia: Moderate (PARTNER-DDS Questionnaire Question)\tBreathing bag, device (Anesthesia/Respiratory Equipment and Supplies)\tcofilin-actin rod (Cell Component)\tDefined Criterion Group Composition Relationship Sequence Number (Intellectual Product)", + "output": "Defined Criterion Group Composition Relationship Sequence Number (Intellectual Product)" + }, + { + "input": "Definition: Health Services Misuse described as excessive or unnecessary utilization of health services by patients or physicians.\nConcepts: Fusion of middle ear ossicles (Abnormality of the middle ear ossicles)\tAdrenal Cortex Sex Cord-Stromal Tumor (Tumors of Adrenal Cortex)\tOveruses, Health Services (Health Care Activity)\tMucosal Melanoma of the Head and Neck TNM Finding v7 (Finding)\tsuppression of tumorigenicity 6 (Gene or Genome)", + "output": "Overuses, Health Services (Health Care Activity)" + }, + { + "input": "Definition: something described as rRNA-processing protein UTP23 homolog (249 aa, ~28 kDa) is encoded by the human UTP23 gene. This protein is involved in rRNA-processing and ribosome biogenesis.\nConcepts: Colorectal Neuroendocrine Tumor pM1 TNM Finding v8 (Finding)\tC8orf53 (Regulatory Protein)\tSet of vessels of nerves (Body Part, Organ, or Organ Component)\tGammaGlutamyl Transferase Excretion Rate (Laboratory Procedure)\tVisitation Facilitation (Health Care Activity)", + "output": "C8orf53 (Regulatory Protein)" + }, + { + "input": "Definition: Organic Chemical described as a second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, glisoxepide exerts greater binding affinity than the first-generation compounds. Glisoxepide shows peroxisome proliferator-activated receptor (PPAR) gamma agonistic activity, has a short half-life and is excreted in both the bile and urine. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C72801\" active clinical trials using this agent.\nConcepts: Prosthetic Material Dental Scissors (Scissors, Dental)\tpostsynaptic neurotransmitter receptor cycle (neurotransmitter receptor cycle)\tGlisoxepide (Pharmacologic Substance)\tEffervescent granules + film-coated tablet (Combined Dosage Form)\tLeiomyosarcoma of the Vagina (sarcoma of vagina)", + "output": "Glisoxepide (Pharmacologic Substance)" + }, + { + "input": "Definition: Congenital malformation of upper alimentary tract described as fissure or split of the palate. (Makris S, Solomon HM, Clark R, Shiota K, Barbellion S, Buschmann J, Ema M, Fujiwara M, Grote K, Hazelden KP, Hew KW, Horimoto M, Ooshima Y, Parkinson M, Wise LD. Terminology of developmental abnormalities in common laboratory mammals (Version 2). Part B. Birth Defects Res B Dev Reprod Toxicol. 2009 Aug;86(4):227-327.)\nConcepts: Lysostaphin (Anti-Bacterial Agents)\tACUTE LEUKEMIA (Myeloproliferative disease)\tGeneral anaesthesia (Anaesthesia and allied procedures)\tCleft palate, unspecified (Oral cavity)\thalf bridge of mitotic spindle pole body (half bridge of spindle pole body)", + "output": "Cleft palate, unspecified (Oral cavity)" + }, + { + "input": "Definition: something described as units designed to warm or cool a patient by circulating liquid. These units consist of a central device including a cooling system (similar to a household refrigerator), a heating element, and pumps for circulating liquid; a specially designed reusable or disposable blanket with appropriate channels for liquid circulation; controls; and alarms. Patient temperature is typically monitored with a thermometer. Circulating-liquid patient warming/cooling units are used for rewarming patients on postanesthesia care units, to help prevent intraoperative hypothermia or to induce hypothermia in the operating room, and to cool feverish patients.\nConcepts: State, Prediabetic (Endocrine finding)\tA. alternata IgE AB RAST Score (Immunoglobulin E measurement)\tMicrophthalmia, retinitis pigmentosa, foveoschisis, optic disc drusen syndrome (Disorder of macula of retina)\tWarming/Cooling Units, Patient, Circulating-Liquid (Warming/Cooling Units, Patient)\t15: 64781738-64861380 (Chromosome 15 Physical Location)", + "output": "Warming/Cooling Units, Patient, Circulating-Liquid (Warming/Cooling Units, Patient)" + }, + { + "input": "Definition: antibiotic biosynthetic process described as the chemical reactions and pathways resulting in the formation of phenol, a compound that consists of a benzene ring with one attached hydroxyl group.\nConcepts: L-arginine carboxy-lyase (Molecular Function)\tphenol biosynthetic process (Molecular Function)\tMicroanatomy (Biological Science Disciplines)\tComprehensive melatonin profile each test (Laboratory Procedure)\tcyclitis (Disorder of ciliary body)", + "output": "phenol biosynthetic process (Molecular Function)" + }, + { + "input": "Definition: Duplication of the proximal phalanx of hand described as partial or complete duplication of the fifth proximal phalanx of hand.\nConcepts: RCPCTAUW (Percent Recovered Over Dosing Interval)\tMAP kinase kinase 3, human (Enzyme)\tPartial/complete duplication of the proximal phalanx of the 5th finger (Duplication of phalanx of 5th finger)\tXenygloxal (Antiviral Agents)\tEC 2.4.1.198 (glycosyltransferase)", + "output": "Partial/complete duplication of the proximal phalanx of the 5th finger (Duplication of phalanx of 5th finger)" + }, + { + "input": "Definition: Finding described as a subjective score of 8 on a difficulty falling asleep scale that ranges from 0: No difficulty to 10: Didn't fall asleep.\nConcepts: Abnormal uridine diphosphate glucose-4-epimerase level in red blood cells (Finding)\tdown-regulation of autophagic cell death (negative regulation of programmed cell death)\tDifficulty Falling Asleep Score 8 (Finding)\tCorrespondence (Study Material)\tReceptor Tyrosine-Protein Kinase erbB-1 L792F (Cell or Molecular Dysfunction)", + "output": "Difficulty Falling Asleep Score 8 (Finding)" + }, + { + "input": "Definition: something described as surgical clamps designed for the atraumatic grasping and/or compression of the meatus and polypoid growths (i.e., caruncles) in the urinary membrane of the meatus in women. These clamps are typically handheld, manual instruments including two parts pivoted at the center with two straight, tapering, distal jaws and a ratchet handle. Urethral meatus/caruncle surgical clamps are used in meatotomy and in the excision of caruncles.\nConcepts: Non-plaque induced gingival disease (Gingival Diseases)\tGvHD Lung Obstructive Function Score (Research or Clinical Assessment Tool)\tClamps, Surgical, Urethral Meatus/Caruncle (Medical Device)\tthird eyelid (Animal Structures)\tFactor VIII (Laboratory Procedure)", + "output": "Clamps, Surgical, Urethral Meatus/Caruncle (Medical Device)" + }, + { + "input": "Definition: RICKETTSIOSES AND OTHER ARTHROPOD-BORNE DISEASES described as an infection that is caused by Rickettsia prowazekii, which is transmitted to humans from infected lice; manifestations include sudden headache, generalized muscle pain, malaise, macular skin lesions, and encephalitis.\nConcepts: throat carcinoma (Malignant Neoplasms)\tethylene binding (alkene binding)\tInfection, Rickettsia prowazekii (TYPHUS)\tHAQ01-Reach-Get Down 5 Lb Obj Above Head (HAQ-DI Questionnaire Question)\tMalassezia ovale (Form family Cryptococcaceae)", + "output": "Infection, Rickettsia prowazekii (TYPHUS)" + }, + { + "input": "Definition: Cell Component described as a protein complex that comprises one integrin alphav subunit, one integrin beta5 subunit, and vitronectin.\nConcepts: Deuteranomaly (Congenital color blindness)\tcohort dose (Dosage)\t13: 50925135-50837364 (Spatial Concept)\tFACT-BL Version 4 - Enjoy Things I Usually Do for Fun (FACT-BL Version 4 Questionnaire Question)\talphav-beta5 integrin-vitronectin complex (plasma membrane protein complex)", + "output": "alphav-beta5 integrin-vitronectin complex (plasma membrane protein complex)" + }, + { + "input": "Definition: MALE REPRODUCTIVE FUNCTIONS AND SYMPTOMS described as the maturation and propagation of spermatozoa. The process consists of three phases, mitosis, meiosis, and spermiogenesis. This results in a specialized cell that is capable of traversing the male and female reproductive tracts, and has the capability of fertilizing an egg.\nConcepts: Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype (Ki-1+ Anaplastic Large Cell Lymphoma)\tUneven increase in bone density in the middle bone of the little finger (Anatomical Abnormality)\tspermatogenesis (Gametogenesis)\tgene conversion at mating-type locus, DNA double-strand break processing (Reproductive process)\tStructure of interfoveolar ligament (Body Part, Organ, or Organ Component)", + "output": "spermatogenesis (Gametogenesis)" + }, + { + "input": "Definition: Multidenominational care described as assisting a client in activities that enhance his or her sense of purpose, meaning and/or hope. Service is billed in 15-minute increments.\nConcepts: Fowl Pox Virus (Virus)\tSpiritual growth facilitation (Coping Assistance)\tGrade 4 Joint Infection, CTCAE (Joint Infection, CTCAE)\tchondrocyte differentiation involved in endochondral bone morphogenesis (Cell Function)\tCollaborating in fluid and electrolyte management (Health Care Activity)", + "output": "Spiritual growth facilitation (Coping Assistance)" + }, + { + "input": "Definition: something described as descriptive of a condition that may or is likely to become cancerous.\nConcepts: Precancerous (Disease Morphology Qualifier)\tGrade 4 Pregnancy loss (Finding)\tsystemic mastocytosis w/ assoc clonal hematologic non-mast cell lineage disease (Malignant tumor of lymphoid hemopoietic and related tissue)\tHMG2A (Gene or Genome)\tLactobacillus brevis CD2 Lozenge (Biological Response Modifiers)", + "output": "Precancerous (Disease Morphology Qualifier)" + }, + { + "input": "Definition: carboxylic acid metabolic process described as the chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids.\nConcepts: icosanoid metabolic process (fatty acid derivative metabolic process)\tHydronephrosis NOS (Kidney finding)\tIntellectual disability, enteropathy, deafness, peripheral neuropathy, ichthyosis, keratoderma syndrome (Erythrokeratoderma)\tnegative regulation of cell adhesion involved in sprouting angiogenesis (negative regulation of cell adhesion)\ttrans-docosan-2-enoyl-CoA reductase activity (Molecular Function)", + "output": "icosanoid metabolic process (fatty acid derivative metabolic process)" + }, + { + "input": "Definition: Intellectual Product described as functional Assessment of Cancer Therapy-Lung Symptom Index (FLSI) I have been short of breath.\nConcepts: juniperus (Plant)\tinterferon beta-secreting mesenchymal stem cells (Antineoplastic Immune Cell)\tAvian tuberculosis (Disease or Syndrome)\tFAC04301 (FLSI Questionnaire Question)\tAsterococcus fermentans (Mycoplasma species)", + "output": "FAC04301 (FLSI Questionnaire Question)" + }, + { + "input": "Definition: Quantitative Concept described as gigabecquerel per microliter.\nConcepts: Remedial Reading (Teaching & Teaching Methods)\tgigabecquerel/microlitre (Radioactivity Concentration Unit)\tTKF (Gene or Genome)\tprecorrin-2 C20-methyltransferase activity (Molecular Function)\tNumerical Ability (Cognition)", + "output": "gigabecquerel/microlitre (Radioactivity Concentration Unit)" + }, + { + "input": "Definition: Histogenic Process described as a process of blood formation and more specifically formation of blood cells that are all derived from hematopoietic stem cells.\nConcepts: mADPr binding (ADP-D-ribose binding)\tblood cell formation (Histogenic Process)\tCDISC SDTM Biospecimen Events Dictionary Derived Term Terminology (Intellectual Product)\tHomozygous (Zygosity)\tACER3 gene (Gene or Genome)", + "output": "blood cell formation (Histogenic Process)" + }, + { + "input": "Definition: Congenital Abnormality described as piebaldism is a rare congenital pigmentation skin disorder with characteristic of the presence of hypopigmented and depigmented skin areas (leukoderma) on various parts of the body, preferentially on the forehead, chest, abdomen, upper arms, and lower extremities, that are associated with a white forelock (poliosis), and in some cases with hypopigmented and depigmented eyebrows and eyelashes.\nConcepts: p-nitrophenol metabolism (nitrogen compound metabolic process)\tAntibody test; Epstein-Barr (EB) virus, nuclear antigen (Laboratory Procedure)\taffinity labeling (Laboratory Procedure)\t2,3,5-Tris(ethyleneimine)benzoquinone (Pharmacologic Substance)\tpartial albinism (Congenital Abnormality)", + "output": "partial albinism (Congenital Abnormality)" + }, + { + "input": "Definition: something described as a dose form that displays properties of a solid.\nConcepts: NON-TARGET ENHANCING (Lesion Identification)\tpentachlorophenol (Organochlorine insecticide)\tBasic dose form with solid state of matter (Basic Dose Form)\tImmunoglobulin G measurement (IgG synthesis rate measurement)\tMinimum Time Allowed in Planned Assessment Interval (Temporal Concept)", + "output": "Basic dose form with solid state of matter (Basic Dose Form)" + }, + { + "input": "Definition: BEBQ Concurrent Version Questionnaire Question described as baby Eating Behaviour Questionnaire Concurrent Version (BEBQ Concurrent Version) My baby seems contented while feeding.\nConcepts: 1,3-Oxazole (Heterocyclic Compounds, 1-Ring)\tShigella biogroup C (Bacterium)\tBEBQ0101 (Intellectual Product)\tClinic/Center - Augmentative Communication (Manufactured Object)\tCapsulitides (Arthritis)", + "output": "BEBQ0101 (Intellectual Product)" + }, + { + "input": "Definition: Non-site specific necrosis and vascular insufficiency NEC described as pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.\nConcepts: development of secondary female sexual characteristics (Organism Function)\tnausea symptoms (gastrointestinal function)\tTIMI Flow-1 (Thrombolysis in Myocardial Infarction Flow)\tGAUGE, MEASURING (Medical Device)\tARTERIAL OCCLUSIVE DIS (Vascular Diseases)", + "output": "ARTERIAL OCCLUSIVE DIS (Vascular Diseases)" + }, + { + "input": "Definition: something described as human HLA-DOB wild-type allele is located in the vicinity of 6p21.3 and is approximately 4 kb in length. This allele, which encodes HLA class II histocompatibility antigen, DO beta chain protein, is involved in the regulation of presentation of exogenous peptides.\nConcepts: PHQ-9 - Feeling Down, Depressed, or Hopeless (PHQ-9 Questionnaire Question)\tglial cell migration in posterior lateral line nerve (lateral line nerve glial cell migration)\tmicrovillus organization (plasma membrane bounded cell projection organization)\tDOB (Gene or Genome)\tDocetaxel-loaded PMs (Pharmacologic Substance)", + "output": "DOB (Gene or Genome)" + }, + { + "input": "Definition: something described as amniotic constriction rings affecting the arms.\nConcepts: Analogs, Prostaglandin A (Prostaglandins, Synthetic)\t15q23-q24 (Chromosome band)\tmast cell homeostasis (Cell Function)\tAmniotic constriction rings of arms (Abnormality of the upper limb)\tK(Lysine) Acetyltransferase 2B wt Allele (KAT2B gene)", + "output": "Amniotic constriction rings of arms (Abnormality of the upper limb)" + }, + { + "input": "Definition: something described as microscopic hematuria; minimal increase in frequency, urgency, dysuria, or nocturia; new onset of incontinence\nConcepts: Orodispersion (Therapeutic or Preventive Procedure)\tASIP (Adaptor Proteins, Signal Transducing)\tFibroblast Growth Factor-19 Positive (Laboratory or Test Result)\tGrade 1 Cystitis Noninfective, CTCAE (Cystitis Noninfective, CTCAE)\tRegulatory Authority Jurisdiction Authority Code (Intellectual Product)", + "output": "Grade 1 Cystitis Noninfective, CTCAE (Cystitis Noninfective, CTCAE)" + }, + { + "input": "Definition: Elements described as metals with low specific gravity, typically smaller than 5, characterized by a single valence (1, 2, or 3), a simple spectrum, strong electromotive force (positive), and colorless compounds.\nConcepts: Minute Times Nanogram Per Milliliter Per Milligram Per Gram (Measurement Unit Description)\tAlpha-Smooth Muscle Actin Measurement (Laboratory Procedure)\tLight Metals (Metals)\tLigamentum venosum of liver (Transformed vein)\tUterine Corpus Carcinoma and Carcinosarcoma Clinical TNM Finding v8 (Uterine Corpus Carcinoma and Carcinosarcoma TNM Finding v8)", + "output": "Light Metals (Metals)" + }, + { + "input": "Definition: neuron projection membrane described as the portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness.\nConcepts: Viable Cells/Femur (Unit of Cell Concentration)\tAVLT-REY - Recognition Intrusions (AVLT-REY Functional Test Question)\tAxolemma (neuron projection membrane)\tMps1 Inhibitor BAY 1217389 (Serine/Threonine Kinase Inhibitor)\tMalignant peripheral nerve sheath tumor, epithelioid (Primary malignant neoplasm of peripheral nerve)", + "output": "Axolemma (neuron projection membrane)" + }, + { + "input": "Definition: Lithotripter described as mobile modular medical facilities typically divided into a patient treatment area, an operator room that may include a console, and an auxiliary equipment (e.g., electric generator, air conditioning) room. These facilities include a lithotripter (e.g., ultrasonic, electrohydraulic), a urological table, and endoscopic devices.\nConcepts: Lithotripsy mobile medical facility (Lithotripter)\tVisceral nervous system (Peripheral Nervous System)\tIPI (Assessment scales)\tADL0317E (ADCS-ADL MCI Questionnaire Question)\tAntrum (Body Part, Organ, or Organ Component)", + "output": "Lithotripsy mobile medical facility (Lithotripter)" + }, + { + "input": "Definition: Biologic Function described as any process that regulates the frequency of action potentials in a spike train.\nConcepts: Wide nasal base (Abnormal nasal base)\tTubular Adenoma of the Extrahepatic Bile Duct (Benign neoplasm of extrahepatic bile ducts)\tECSTDY (Temporal Concept)\tOsteonecrosis, CTCAE (Musculoskeletal and Connective Tissue Disorders, CTCAE)\tregulation of action potential firing rate (regulation of action potential)", + "output": "regulation of action potential firing rate (regulation of action potential)" + }, + { + "input": "Definition: Antibody described as a measurement of the Epstein-Barr nuclear antigen in a biological specimen.\nConcepts: Reductases, Nitrite (Enzyme)\tAntibody test; Epstein-Barr (EB) virus, nuclear antigen (Laboratory Procedure)\tNEOMYCIN (Otic preparation)\tBiological Process Has Result Chemical Or Drug (Idea or Concept)\tmethylation dependent binding protein, human (Amino Acid, Peptide, or Protein)", + "output": "Antibody test; Epstein-Barr (EB) virus, nuclear antigen (Laboratory Procedure)" + }, + { + "input": "Definition: Orphan Nuclear Receptors described as nuclear receptor subfamily 2 group C member 2 (596 aa, ~65 kDa) is encoded by the human NR2C2 gene. This protein is involved in both hormone binding and transcriptional regulation.\nConcepts: Antigen Presentations (Immune System Processes)\tStructure of posterior auricular vein (Posterior auricular vein and its tributaries)\tOrphan Nuclear Receptor TAK1 (Receptors, Nuclear)\tregulation of cap-dependent translational initiation (regulation of cytoplasmic translational initiation)\thomodimeric serine palmitoyltransferase complex location (Cell Component)", + "output": "Orphan Nuclear Receptor TAK1 (Receptors, Nuclear)" + }, + { + "input": "Definition: leiomyosarcoma described as a leiomyosarcoma that arises from the paratesticular region.\nConcepts: Benign Appendix Neoplasm (Appendiceal Neoplasms)\tTesticular Cancer pN3 TNM Finding v7 (Testicular Cancer Pathologic Regional Lymph Nodes TNM Finding v7)\tmRNA 3'-UTR binding (mRNA binding)\tParatesticular Leiomyosarcoma (leiomyosarcoma)\tFixed Cryogenic Vessel (Medical Devices)", + "output": "Paratesticular Leiomyosarcoma (leiomyosarcoma)" + }, + { + "input": "Definition: Epidermal growth factor receptor inhibitor described as an orally available third-generation, selective inhibitor of certain forms of the epidermal growth factor receptor (EGFR) with activating mutations, including the resistance mutation T790M, exon 19 deletions (Del19), and the L858R mutation, with potential antineoplastic activity. Upon administration, lazertinib specifically and irreversibly binds to and inhibits selective EGFR mutants, which prevents EGFR mutant-mediated signaling and leads to cell death in EGFR mutant-expressing tumor cells. Lazertinib may inhibit programmed cell death-1 ligand 1 (PD-L1) and inflammatory cytokines in specific cancer cells harboring certain EGFR mutations. Compared to some other EGFR inhibitors, lazertinib may have therapeutic benefits in tumors with T790M- or L858R-mediated drug resistance. In addition, lazertinib penetrates the blood-brain barrier (BBB). This agent shows minimal activity against wild-type EGFR (wtEGFR), and does not cause dose-limiting toxicities, which occur during the use of non-selective EGFR inhibitors and inhibit wtEGFR. EGFR, a receptor tyrosine kinase (RTK) mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.\nConcepts: EORTC QLQ-C30 Version 3 - Need Help Eating, Dressing, Washing (Intellectual Product)\tdefects in the complement system (Immune system disorders congenital)\tUpper Jaw Tooth (Tooth structure)\tAPOBAPA1 (Laboratory Procedure)\tLazertinib (Epidermal growth factor receptor inhibitor)", + "output": "Lazertinib (Epidermal growth factor receptor inhibitor)" + }, + { + "input": "Definition: MRCM reference set described as MRCM reference set that associates attributes with a valid range of values.\nConcepts: CVTPT (Planned Time Point Name)\tmetabolism methionine (Molecular Function)\tv-ets erythroblastosis virus E26 oncogene homolog 2 (Gene or Genome)\tMRCM attribute range reference set (MRCM reference set)\tATP:[glutamate-ammonia-ligase] adenylyltransferase activity (adenylyltransferase activity)", + "output": "MRCM attribute range reference set (MRCM reference set)" + }, + { + "input": "Definition: something described as a long-acting recombinant fusion protein incorporating human serum albumin (HSA)-derived and human granulocyte colony stimulating factor (G-CSF)-derived moieties with potential granulopoietic activity. G-CSF, a naturally occurring cytokine, stimulates the production of granulocytes and stem cells in the bone marrow and their release into the blood; it also stimulates the differentiation, function, and survival of neutrophil precursors and mature neutrophils. Albumin fusion may promote an increased serum half-life and bioavailability of the G-CSF moiety of this fusion protein.\nConcepts: Perinatal death grief assist (mental health counseling)\tRecombinant Human Albumin-Human Granulocyte Colony-Stimulating Factor (Pharmacologic Substance)\tLEC (Chemokine Measurement)\tIndividual attitudes of people in positions of authority (CHAPTER 4 ATTITUDES)\tHETYPE (Qualitative Concept)", + "output": "Recombinant Human Albumin-Human Granulocyte Colony-Stimulating Factor (Pharmacologic Substance)" + }, + { + "input": "Definition: IVD Test Reagent/Kits, Clinical Chemistry described as clinical chemistry reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (typically urine) to determine dehydroepiandrosterone (DHEA) and/or DHEA-sulfate metabolites, including 17-ketosteroid sulfate and 17-ketosteroid glucoronides (17-KS-G). Determination of DHEA metabolites in urine is used to assess the health status of patients (both physical and mental), especially under stress conditions.\nConcepts: Conversing with one person (conversation)\tIVD Test Reagent/Kits, Clinical Chemistry, Dehydroepiandrosterone Metabolite (IVD Test Reagent/Kits, Clinical Chemistry)\tHistone Cluster 1 H1 Family Member C Gene (Gene or Genome)\tPhysical Regulation Component (Diagnosis)\tComplete duplication of the proximal phalanges of the hand (Anatomical Abnormality)", + "output": "IVD Test Reagent/Kits, Clinical Chemistry, Dehydroepiandrosterone Metabolite (IVD Test Reagent/Kits, Clinical Chemistry)" + }, + { + "input": "Definition: Methods described as modality used to determine minimal residual disease.\nConcepts: VACTOSERTIB (Organic Chemical)\tMy Clothes Do Not Fit (Clinical or Research Assessment Question)\tNucleus pulvinaris inferior thalami (Thalamic Nuclei)\tMinimal Residual Disease Method (Methods)\tHPV 16 L1-VLP (Human Papilloma Virus Vaccine)", + "output": "Minimal Residual Disease Method (Methods)" + }, + { + "input": "Definition: something described as catalysis of the reaction: laricitrin(1-) + S-adenosyl-L-methionine <=> H+ + 3',4'-dimethylmyricetin + S-adenosyl-L-homocysteine.\nConcepts: LEC0104C (Intellectual Product)\tlaricitrin 4'-O-methyltransferase activity (methyltransferase activity)\ttesticular fusome organization (Cell Function)\tPeriosteal Desmoid Tumor (Disease or Syndrome)\tInsulator Elements (Genome Components)", + "output": "laricitrin 4'-O-methyltransferase activity (methyltransferase activity)" + }, + { + "input": "Definition: regulation of nitrogen compound metabolic process described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.\nConcepts: positive regulation of transcription from Pol I promoter (positive regulation of transcription, DNA-templated)\tIFL-FOLFIRI Regimen (Therapeutic or Preventive Procedure)\tregulation of protein metabolic process (regulation of nitrogen compound metabolic process)\tAppendiceal Carcinoma TNM Finding v8 (Finding)\tTest Article Physical Substance Classification (Classification)", + "output": "regulation of protein metabolic process (regulation of nitrogen compound metabolic process)" + }, + { + "input": "Definition: ergot alkaloid metabolic process described as the chemical reactions and pathways involving chanoclavine-I.\nConcepts: Special Histology Staining (Laboratory Procedure)\tSINODONTY (Congenital anomaly of tooth)\tchanoclavine-I metabolism (primary alcohol metabolic process)\t-deoxyhypusine synthase (transferase activity, transferring alkyl or aryl (other than methyl) groups)\tEBV Related Non-Hodgkin's Lymphoma (Neoplastic Process)", + "output": "chanoclavine-I metabolism (primary alcohol metabolic process)" + }, + { + "input": "Definition: Unit of mass described as the metric unit of mass equal to one billionth of a gram (10E-9 gram) or one thousandth of a milligram.\nConcepts: Barriers, Blood-Retinal (Retina)\tUnidentified Immunodeficiency (Disease or Syndrome)\tHIV-1 Group M and O Nucleic Acid (Human immunodeficiency virus test)\tHygiene (Clinical or Research Assessment Answer)\tNANOGRAM (SI unit of mass)", + "output": "NANOGRAM (SI unit of mass)" + }, + { + "input": "Definition: something described as a phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another.\nConcepts: deoxyribose phosphate catabolism (organophosphate catabolic process)\tBile Duct Mucinous Cystic Neoplasm with Intermediate Grade Intraepithelial Neoplasia (Hepatobiliary Precancerous Condition)\tamyloid-beta clearance by transcytosis (Cell Function)\treversible differentiation (phenotypic switching)\tLeft Cardiac Ventricular Systolic Dysfunction (Myocardial dysfunction)", + "output": "reversible differentiation (phenotypic switching)" + }, + { + "input": "Definition: dopaminergic cell groups described as a small group of cells fluorescent for dopamine in the human ( Halliday-2012 ), macaque ( Felten-1983 ), rat ( Dahlstrom-1964 ) and mouse ( Franklin-2008 ). It is located in the midbrain reticular formation dorsolateral to the substantia nigra at the level of the red nucleus and caudally. It overlaps the classically defined retrorubral area and, in the human, the midbrain reticular field ( Halliday-2012 ).\nConcepts: Irisin Gene (Gene or Genome)\thexabrachion (Biologically Active Substance)\tA8 cell group (Cell)\tERBB1 c.2572 2573CT>AA (Cell or Molecular Dysfunction)\tMICROSCOPE, OPERATING, NON-ELECTRIC, OPHTHALMIC (Medical Device)", + "output": "A8 cell group (Cell)" + }, + { + "input": "Definition: Conotoxins described as a 13-amino acid alpha-conotoxin that is isolated from the venom of the cone snail Conus geographus. It is a competitive antagonist of the muscle-type nicotinic acetylcholine receptors, blocking synaptic transmission at the neuromuscular junction. Alpha-conotoxins are identified by a characteristic arrangement of four-cysteine residues (-CC-C-C-) and disulfide bonding of Cys1-Cys3 and Cys2-Cys4.\nConcepts: BRN (Asia, Southeastern)\tTobacco Induced Hyperparakeratosis (Disease or Syndrome)\tAlpha-GI (Amino Acid, Peptide, or Protein)\tThoracic duct (Lymphatic vessel)\tIVD Test Reagent/Kits, Serology, Fungi/Yeast, Cryptococcus neoformans (Medical Device)", + "output": "Alpha-GI (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Cell Function described as any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production.\nConcepts: up regulation of plasmacytoid dendritic cell cytokine production (regulation of plasmacytoid dendritic cell cytokine production)\tHermit Crab (Eukaryote)\tprotein cis-autophosphorylation (protein autophosphorylation)\tMedroxyprogest acetate [progestogen oral contraceptive] (Hormone)\tsubarachnoid hemorrhages (Subarachnoid Hemorrhage)", + "output": "up regulation of plasmacytoid dendritic cell cytokine production (regulation of plasmacytoid dendritic cell cytokine production)" + }, + { + "input": "Definition: Quantitative Concept described as a constant of proportionality that exists between electric displacement and electric field intensity in a vacuum. This constant is equal to approximately 8.854187817x10E-12 farad per meter (F/m).\nConcepts: non-adjuvanted A(H1N1) influenza vaccine (Viral Vaccines)\tPermittivity of Free Space (Fundamental Physical Constant)\tcell wall polysaccharide synthesis (Molecular Function)\tliposomal MUC1/PET-lipid A vaccine (Immunologic Factor)\tCarcinoma Arising in Nasal Papillomatosis (Nasal cavity carcinoma)", + "output": "Permittivity of Free Space (Fundamental Physical Constant)" + }, + { + "input": "Definition: Immunoglobulin Light Chain Measurement described as a measurement of the total free immunoglobulin (kappa and lambda) light chains in a biological specimen.\nConcepts: IMMGLCFR (Laboratory Procedure)\tReplication-Associated Process (Genetic Function)\tText Structure (Functional Concept)\tRecurrent joint dislocations (Recurrent disease)\tnodule hyperpigmented (Finding)", + "output": "IMMGLCFR (Laboratory Procedure)" + }, + { + "input": "Definition: Secondary malignant neoplasm of bone described as cancer that has spread from the original (primary) tumor to the bone.\nConcepts: Secondary malig neo bone (Malignant musculoskeletal and connective tissue neoplasms)\tAnsamycin Antineoplastic Antibiotic (Heat Shock Protein Inhibitor)\tPolycyclic (Spatial Concept)\tInfantile spasms, broad thumbs syndrome (Epilepsy)\tStem Cell Transplantation, Syngenic (Therapeutic or Preventive Procedure)", + "output": "Secondary malig neo bone (Malignant musculoskeletal and connective tissue neoplasms)" + }, + { + "input": "Definition: Rehabilitative treatments and/or training described as training a client to perform activities of daily living (for example, to sit, stand, transfer from one position to another, feed and groom himself or herself and manage bodily functions). Service is billed in 15-minute increments.\nConcepts: Human Umbilical Cord Perivascular Cell (Mesenchymal Stem Cells)\tSelf-care training individual each 15 minutes (Therapeutic or Preventive Procedure)\tmenstruations (Organism Function)\tPhysician Support (health system management)\tDose Length Product (Derived Unit of International System of Units)", + "output": "Self-care training individual each 15 minutes (Therapeutic or Preventive Procedure)" + }, + { + "input": "Definition: regulation of cap-dependent translational initiation described as any process that activates or increases the frequency, rate or extent of cap-dependent translational initiation.\nConcepts: PQL1710 (Intellectual Product)\tup regulation of cap-dependent translational initiation (regulation of cap-dependent translational initiation)\tAnti-PD-L1/4-1BB Bispecific Antibody MCLA-145 (Immune Checkpoint Inhibitors)\tpNX Colorectal Carcinoma (Finding)\tWalking 30 Yards (Clinical or Research Assessment Question)", + "output": "up regulation of cap-dependent translational initiation (regulation of cap-dependent translational initiation)" + }, + { + "input": "Definition: something described as functions associated with the onset of puberty and manifestations of primary and secondary sexual characteristics.\nConcepts: Pubertal functions (Endocrine gland functions)\tRefractory Malignant Peripheral Nerve Sheath Tumor (Malignant Peripheral Nerve Sheath Tumor)\tPeroxidase, Chloride (Peroxidases)\tTherapeutic apheresis, NOS (Procedures on veins)\tanti-VEGF/ANG2 nanobody BI 836880 (Pharmacologic Substance)", + "output": "Pubertal functions (Endocrine gland functions)" + }, + { + "input": "Definition: Peptidylprolyl Isomerase described as a highly-conserved peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated SERINE- or THREONINE-PROLINE (pSer/Thr-Pro) motifs and causes conformational changes in certain proteins associated with the CELL CYCLE. It displays a preference for an acidic residue N-terminal to the isomerized proline bond and regulates MITOSIS, possibly by attenuating the mitosis-promoting activity of NIMA-RELATED KINASE 1.\nConcepts: DNA replication involved in S phase (Genetic Function)\tEicosanoid Metabolism Pathway (Lipid Metabolism Pathway)\tPeptidyl Prolyl Cis Trans Isomerase Pin1 (Peptidylprolyl Isomerase)\tFetal heart finding (Fetal finding)\tNephroblastomatosis (Kidney)", + "output": "Peptidyl Prolyl Cis Trans Isomerase Pin1 (Peptidylprolyl Isomerase)" + }, + { + "input": "Definition: Bacterium described as a species of gram-negative, fluorescent, phytopathogenic bacteria in the genus PSEUDOMONAS. It is differentiated into approximately 50 pathovars with different plant pathogenicities and host specificities.\nConcepts: three dimensional imaging/topography (imaging/visualization/scanning)\ttermination of signal transduction (Physiologic Function)\tPseudomonas syringae van Hall 1902 (Pseudomonas syringae group)\tSubstance Administration Individual Case Safety Report Terminology (FDA Individual Case Safety Report Terminology)\tThrombus of right atrium (Pathologic Function)", + "output": "Pseudomonas syringae van Hall 1902 (Pseudomonas syringae group)" + }, + { + "input": "Definition: Vertebral column described as anterior tongue-like protrusions of the vertebral bodies.\nConcepts: Bandages, Retention, Non-Elastic, Cotton/Gauze (Medical Device)\tDisease in remission (Severity of illness)\tGestational Trophoblastic Neoplasm Clinical Distant Metastasis TNM Finding v8 (Finding)\tAnterior beaking of vertebral bodies (Finding)\tGranules in Sachet (Biomedical or Dental Material)", + "output": "Anterior beaking of vertebral bodies (Finding)" + }, + { + "input": "Definition: Functional Concept described as force applied by the masticatory muscles in dental occlusion.\nConcepts: Occlusal Forces (Functional Concept)\tBond, Failure To (Finding)\tcysteine rich hydrophobic domain 2 (Gene Mutation)\tBCR-ABL L384M Mutation (Amino Acid, Peptide, or Protein)\tendobronchial ultrasonography (Endoscopic Ultrasound)", + "output": "Occlusal Forces (Functional Concept)" + }, + { + "input": "Definition: Peptides described as a 39 amino acid peptide and synthetic version of exendin-4, a hormone found in the saliva of the venomous lizard Gila monster, with insulin secretagogue and antihyperglycemic activity. Exenatide is administered subcutaneously and mimics human glucagon-like peptide-1 (GLP-1). Compared to GLP-1, exenatide has a longer half-life of 2.4 hours.\nConcepts: Clinical Trial Startup Material (Intellectual Product)\tgranzyme-mediated apoptotic signaling pathway (apoptotic signaling pathway)\tProtein Kinase Protein Phosphorylation (Protein phosphorylation)\tdown-regulation of transcription from RNA polymerase II promoter by glucose (negative regulation of transcription from RNA polymerase II promoter by glucose)\tExenatida (Glucagon-like peptide-1 (GLP-1) analogues)", + "output": "Exenatida (Glucagon-like peptide-1 (GLP-1) analogues)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar.\nConcepts: nucleoside diphosphate metabolic process (nucleoside phosphate metabolic process)\tparticipatingLocationCode (Code)\tArsenic Measurement (Chemical procedure)\tType 1 Secretion Systems (Amino Acid, Peptide, or Protein)\tChildhood Pilomyxoid Astrocytoma (Neoplastic Process)", + "output": "nucleoside diphosphate metabolic process (nucleoside phosphate metabolic process)" + }, + { + "input": "Definition: protein localization to synapse described as any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.\nConcepts: Ornithinemia with Gyrate Atrophy (Hereditary disorder of the visual system)\tNCI Tissue Expediter (Biomedical Occupation or Discipline)\tCMP degradation (pyrimidine ribonucleotide catabolic process)\treceptor localisation to synapse (protein-containing complex localization)\tTests, Genotoxicity (Laboratory Procedure)", + "output": "receptor localisation to synapse (protein-containing complex localization)" + }, + { + "input": "Definition: M [Preparations] described as a synthetic steroid with anabolic and androgenic properties.\nConcepts: PANSS Clinical Classification Question (Intellectual Product)\tregulation of pyrimidine nucleotide synthesis (regulation of nucleotide biosynthetic process)\tHIGH PRESSURE LIQUID CHROMATOGRAPHY, BARBITURATE (Medical Device)\tAssesses baseline musculoskeletal status (Physiologic Responses)\tMethandriol (Adrenal Cortex Hormones)", + "output": "Methandriol (Adrenal Cortex Hormones)" + }, + { + "input": "Definition: something described as the Doctor of Philosophy in Human Services is a postgraduate degree in areas of specialization addressing social challenges within the health care field.\nConcepts: Pneumonectomy (Pneumonectomy)\tDoctor of Philosophy in Human Services (Doctor of Philosophy)\tTLL (Metallopeptidase Gene)\tInfusion Systems, Insulin, Closed-Loop (Medical Device)\tMixed Tumors, Malignant (Mixed Neoplasm)", + "output": "Doctor of Philosophy in Human Services (Doctor of Philosophy)" + }, + { + "input": "Definition: Allergen class described as class of antihypertensive agents which act by inhibiting the proteolytic activation of angiotensin.\nConcepts: Soy Isoflavone (Herbal medicine)\tANGIOTENSIN CONVERTING ENZYME ANTAG (Protease Inhibitors)\tPainful noncancerous fat tissue tumor under the skin (Subcutaneous lipoma)\tDisintegration Constant (Constant Data Value)\tAutologous Ovarian Tumor Cell Lysate-Pulsed Dendritic Cell Vaccine (Pharmacologic Substance)", + "output": "ANGIOTENSIN CONVERTING ENZYME ANTAG (Protease Inhibitors)" + }, + { + "input": "Definition: Organic Chemical described as cyclized forms of acylated HOMOSERINE. Members are involved in bacterial QUORUM SENSING.\nConcepts: acyl-CoA:dolichol acyltransferase activity (O-acyltransferase activity)\tAcyl-Homoserine Lactones (Organic Chemical)\tExtra hair swirls (Abnormal hair whorl)\tMelanoma Antigen Family A 12 (Immunologic Factor)\tS-methylmethionine cycle (Molecular Function)", + "output": "Acyl-Homoserine Lactones (Organic Chemical)" + }, + { + "input": "Definition: Cell described as neuroectodermal cells of the neural crest. They differentiate into various cell types during EMBRYOGENESIS including craniofacial MESENCHYME; ENDOCRINE CELLS; MELANOCYTES and PERIPHERAL NERVOUS SYSTEM.\nConcepts: Anterior Longitudinal Ligament (Structure of ligament of neck)\tproteoglycan sulphotransferase activity (Molecular Function)\tLeuprolide acetate (Gonad regulating hormone agent)\tcells crest neural (Embryonic Cell)\tOverall Quality of Life (Intellectual Product)", + "output": "cells crest neural (Embryonic Cell)" + }, + { + "input": "Definition: Infant Care described as continuous care and monitoring of newborn infants with life-threatening conditions, in any setting.\nConcepts: Low Grade Penile Intraepithelial Neoplasia (Penile intraepithelial neoplasia)\tsyndecan-syntenin-ALIX complex location (extracellular exosome complex)\tCare, Neonatal Intensive (intensive care)\tHistone deacetylase (Amino Acid, Peptide, or Protein)\tEWS-FLI-1 (Fusion protein)", + "output": "Care, Neonatal Intensive (intensive care)" + }, + { + "input": "Definition: Health System described as family members, professionals, or paraprofessionals who provide care to children or to the mentally or physically disabled.\nConcepts: Care Giver (Person in the healthcare environment)\tGAIA Fetal Growth Restriction Level of Diagnostic Certainty Terminology (Intellectual Product)\tMarburg Disease (Filovirus viral infections)\tType IV Hypersensitivities (T cell mediated immunity)\tInjury to Jugular Vein (Injury or Poisoning)", + "output": "Care Giver (Person in the healthcare environment)" + }, + { + "input": "Definition: tRNA methylation described as the process whereby a guanine in a tRNA is methylated at the N2 position of guanine.\nConcepts: tRNA N2-guanine methylation (Genetic Function)\tPast 6 Months (Period)\tVessel Failure Indicator (Indicator)\tFIQR - Symptoms Sub-Total (FIQR Questionnaire Question)\tPolysaccharide Preparation from Bacterial Cells (Laboratory Procedure)", + "output": "tRNA N2-guanine methylation (Genetic Function)" + }, + { + "input": "Definition: something described as an inherited retinal dystrophy characterised by delayed dark adaptation and nyctalopia and drusen deposits presenting in adulthood, followed by cone and rod degeneration that presents in the sixth decade of life, which leads to central vision loss. Anterior segment features such as peripupillary iris transillumination defects and abnormally long anterior zonular insertions are also observed. Choroidal neovascularisation and glaucoma may occur in the late stages of the disease.\nConcepts: Radioimmune Chemistry (Occupation or Discipline)\tPsychotic Paranoia (Psychological Disorders)\tpropanediol catabolism (glycol catabolic process)\tBeds, Electric, Rotation/Rocking (Medical Device)\tAutosomal dominant late-onset retinal degeneration (Autosomal dominant hereditary disorder)", + "output": "Autosomal dominant late-onset retinal degeneration (Autosomal dominant hereditary disorder)" + }, + { + "input": "Definition: something described as hamilton Depression Rating Scale 6 Self-Report Version (HAM-D6 Self-Report Version) (6)=Tiredness and pains per clinician version: How you have been feeling over the past three days, including today.\nConcepts: Zinc Finger and BTB Domain-Containing Protein 46 (Amino Acid, Peptide, or Protein)\tvegetative growth of a single-celled organism (biological phase)\tFactor, Biological (Italian translation of Medical Subject Headings)\tHAMDS106 (Intellectual Product)\tGrade 3 Dermatitis Radiation, CTCAE (Finding)", + "output": "HAMDS106 (Intellectual Product)" + }, + { + "input": "Definition: Disorder of endocrine pancreas described as abnormal increase in the number of otherwise normal cells in the pancreatic islet without tumor formation; it differs from hypertrophy, which is an increase in bulk without an increase in the number of cells.\nConcepts: somatic muscle development (muscle structure development)\tIslet of Langerhans hyperplasia (Abnormality of the pancreatic islet cells)\tMNSI135 (Intellectual Product)\tSynarthrosis (Joints)\tBallast (Device Component or Accessory)", + "output": "Islet of Langerhans hyperplasia (Abnormality of the pancreatic islet cells)" + }, + { + "input": "Definition: something described as tetracycline controlled transactivator (tTA). The original description of a tetracycline-regulated gene expression system is based on two plasmids, one of which constitutively expresses a tetracycline-controlled transactivator protein (tTA), a fusion protein between the tetracycline repressor of E. coli and the transcriptional activation domain of the VP16 protein of herpes simplex virus. The second plasmid contains the gene to be regulated by tTA under the control of an inducible promoter which consists of seven copies of the tetracycline resistance operator (tetO). Since this original description, many modifications have been described.\nConcepts: netupitant and palonosetron hydrochloride (Pharmacologic Substance)\tTTA System (Molecular Biology Research Technique)\tCone-shaped end part of the middle bone of the middle finger (Cone-shaped epiphyses of the middle phalanges of the hand)\tdental technology (Biomedical Occupation or Discipline)\tregulation of protein localization to cell division site involved in mitotic actomyosin contractile ring assembly (regulation of mitotic actomyosin contractile ring assembly)", + "output": "TTA System (Molecular Biology Research Technique)" + }, + { + "input": "Definition: something described as a testicular mixed germ cell-sex cord-stromal tumor. It is usually associated with mixed gonadal dysgenesis and ambiguous genitalia. It is characterized by the presence of nests of large neoplastic germ cells and immature cells that resemble Sertoli cells.\nConcepts: Agglutination Viewers (In Vitro Diagnostics and Laboratory Equipment)\tcancers female reproductive (Genital Neoplasms, Female)\tNeuropeptide Gene (Gene or Genome)\tCSS10-First Attempt Damage (Intellectual Product)\tGonadoblastoma, male (Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified)", + "output": "Gonadoblastoma, male (Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified)" + }, + { + "input": "Definition: Amino acid - dietary described as amino acid which can be readily made by the human body in sufficient amounts.\nConcepts: nonessential amino acid (Amino Acids)\tNeuroscience, Cognitive (Neuroscience discipline)\tmature B cell differentiation involved in immune response (mature B cell differentiation)\tRadiotherapies, Adjuvant (Adjuvant therapy)\tStreptococcus difficilis corrig. Eldar et al. 1995 (Streptococcus agalactiae)", + "output": "nonessential amino acid (Amino Acids)" + }, + { + "input": "Definition: something described as a rare indolent B-cell non-Hodgkin lymphoma characterised by abnormal clonal proliferation of mature B-lymphocytes with involvement in the spleen, bone marrow and, frequently, the blood. It usually presents with splenomegaly, lymphocytosis, anaemia and/or thrombocytopenia. Hepatitis C virus and autoimmune manifestations, such as autoimmune haemolytic anaemia and autoimmune thrombocytopenia could be associated.\nConcepts: National Nanotechnology Initiative Project Component Area 6 (Functional Concept)\tRTA II-Tpe II ren tub acidosis (METABOLIC FEATURES)\tMarginal zone lymphoma of spleen (Indolent Adult Non-Hodgkin Lymphoma)\tLYT10 (NFKB2 gene)\tAutism Spectrum Disorder Gene Mutation Reagents (IVD Panels, Human Genetics, Encephalopathy, Autism Spectrum Disorder)", + "output": "Marginal zone lymphoma of spleen (Indolent Adult Non-Hodgkin Lymphoma)" + }, + { + "input": "Definition: Finding described as life-threatening consequences; urgent intervention indicated\nConcepts: Cardiovascular Function Physiologic Analysis Software (Software, Physiologic Analysis)\tPropenoic Acid Amide (A [Preparations])\tSimultaneously with (Temporal Concept)\tGrade 4 Anorectal Infection, CTCAE (Anorectal Infection, CTCAE)\tPicrolemma Hook.f. (Simaroubaceae)", + "output": "Grade 4 Anorectal Infection, CTCAE (Anorectal Infection, CTCAE)" + }, + { + "input": "Definition: Laboratory Procedure described as the determination of the amount of Hepatitis A virus IgG antibody present in a sample.\nConcepts: Old Age Assistance (Public Assistance)\tlysylprotocollagen dioxygenase activity (Molecular Function)\tHepatitis A Virus IgG Antibody Measurement (Hepatitis A Antibody Measurement)\tesophagus ulceration (Lesion of esophagus)\tkaempferol 4'-O-methyltransferase activity (O-methyltransferase activity)", + "output": "Hepatitis A Virus IgG Antibody Measurement (Hepatitis A Antibody Measurement)" + }, + { + "input": "Definition: Chromosome 2 Physical Location described as physical location of ATF2_Gene\nConcepts: min.ng/ml/g (Quantitative Concept)\t2: 175858404-175763515 (Chromosome 2 Physical Location)\tUterine Corpus Carcinoma pT3b TNM Finding v7 (Uterine Corpus Carcinoma pT3 TNM Finding v7)\tBandage (Biomedical or Dental Material)\tPacemaker or ICD Lead Extraction (Therapeutic or Preventive Procedure)", + "output": "2: 175858404-175763515 (Chromosome 2 Physical Location)" + }, + { + "input": "Definition: something described as a subscale complement to the FACT-G developed specifically for evaluating the quality of life of patients with cancer of the cervix.\nConcepts: soblidotin (Dolastatin Compound)\tHermissendas (Eukaryote)\tFACT-Cx Questionnaire (Intellectual Product)\tLevel 2 Placenta Previa (Intellectual Product)\tSex Differences (Organism Attribute)", + "output": "FACT-Cx Questionnaire (Intellectual Product)" + }, + { + "input": "Definition: Ocular adnexal part described as the section of skin, containing muscle and conjunctiva, that covers and protects the eye.\nConcepts: Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 (Stage IV Pharynx Carcinoma)\tEyelid structure (Set of subdivisions of head)\tGrade 1 Dehydration (Finding)\tDisease, Thomsen (Myotonic Disorders)\tplasma membrane fusion (Cell Function)", + "output": "Eyelid structure (Set of subdivisions of head)" + }, + { + "input": "Definition: ligase activity, forming carbon-nitrogen bonds described as catalysis of the reaction: L-valine + ATP(4-) + a jasmonic acid <=> AMP(2-) + diphosphoric acid + a jasmonoyl-valine.\nConcepts: Were you limited in pursuing your hobbies or other leisure time activities (Findings-Based Question)\tC-SSRS Baseline/Screening Version Phase 1 Study - Active Suicidal Ideation with Some Intent to Act, without Specific Plan (C-SSRS Baseline/Screening Version Phase 1 Study Version 1/14/09 Questionnaire Question)\tPlatelet-Type Bleeding Disorder Gene Mutation Panel Reagents (Medical Device)\tAcidosis NOS (Disorder of fluid AND/OR electrolyte)\tjasmonoyl-valine synthetase activity (ligase activity, forming carbon-nitrogen bonds)", + "output": "jasmonoyl-valine synthetase activity (ligase activity, forming carbon-nitrogen bonds)" + }, + { + "input": "Definition: something described as problem associated with the device insufficiently cooled in device active (working) or/and non-active (nonworking) state.\nConcepts: glycine amidinotransferase activity (amidinotransferase activity)\tCooling, Inadequate (Finding)\tPaired Box Protein Pax-8 (Specific antigen)\tantifungal peptide biosynthetic process (Molecular Function)\tPremature thelarche (Breast)", + "output": "Cooling, Inadequate (Finding)" + }, + { + "input": "Definition: Cerebral Palsy described as a form of spastic cerebral palsy affecting only one limb\nConcepts: Oligonucleotides, Antisense (Biologically Active Substance)\tBAPA (arginine)\tCongenital monoplegia (Disease or Syndrome)\tAbnormal response to endocrine stimulation test (Abnormal endocrine physiology)\tIVD Test Reagent/Kits, Serology, Virus, Retrovirus, HIV-1/2 (IVD Test Reagent/Kits, Serology, Virus, Retrovirus)", + "output": "Congenital monoplegia (Disease or Syndrome)" + }, + { + "input": "Definition: Intellectual Product described as patient Health Questionnaire - 15 (PHQ-15) Menstrual cramps or other problems with your periods [Women only].\nConcepts: GTF2H4 (Gene or Genome)\tFeeling cranky or angry (Clinical or Research Assessment Question)\tdown-regulation of transcription from RNA polymerase II promoter (negative regulation of transcription, DNA-templated)\tPHQ0204 (Intellectual Product)\tOpen Partial Nephrectomy (Partial nephrectomy)", + "output": "PHQ0204 (Intellectual Product)" + }, + { + "input": "Definition: Intellectual Product described as a question about whether an individual is or was bothered by skin problems.\nConcepts: Phycoerythrins, R- (Biologically Active Substance)\tMSQOL-54 - Health a Worry in Life (MSQOL-54 Questionnaire Question)\tSaikos (Plant)\tdown regulation of butyryl-CoA biosynthetic process from acetyl-CoA (negative regulation of purine nucleotide biosynthetic process)\tBothered By Skin Problems (Intellectual Product)", + "output": "Bothered By Skin Problems (Intellectual Product)" + }, + { + "input": "Definition: something described as catalysis of the reactions: a flavanone + NADPH + H+ + O2 = a 3'-hydroxyflavanone + NADP+ + H2O, and a 3'-hydroxyflavanone + NADPH + H+ + O2 = a 3',5'-dihydroxyflavanone + NADP+ + H2O.\nConcepts: F3',5'H (Molecular Function)\tClass Cephalochordata (Chordata, Nonvertebrate)\tPerifollicular erythema (Abnormal perifollicular morphology)\ttumor; placental site trophoblastic (Trophoblastic Neoplasms)\tpositive regulation of intracellular protein transport (positive regulation of intracellular transport)", + "output": "F3',5'H (Molecular Function)" + }, + { + "input": "Definition: Convulsive therapy described as a procedure in which a series of short duration electric currents are passed via electrodes through the brain to cause a controlled seizure for the purpose of treating severe, intractable forms of mental illness, including depression, mania, and catatonia.\nConcepts: pneumonia; aspiration (Aspiration pneumonitis)\tNeurobehavioral stress (Mental Process)\tElectric Convulsive Therapy (Electroconvulsive Therapy)\tGrade 3 Cranial nerve infection (Cranial Nerve Infection, CTCAE)\tLET7, C. ELEGANS, HOMOLOG OF, I (Gene or Genome)", + "output": "Electric Convulsive Therapy (Electroconvulsive Therapy)" + }, + { + "input": "Definition: renal system process involved in regulation of blood volume described as the process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus.\nConcepts: Retreatment of Progressive Local Disease with Cryotherapy and HIFU (Therapeutic or Preventive Procedure)\tMilk Acid (lactate)\tEDC (Conceptual Entity)\ttubuloglomerular feedback (Physiologic Function)\tKIAA1626 (ARHGEF10L gene)", + "output": "tubuloglomerular feedback (Physiologic Function)" + }, + { + "input": "Definition: Device associated with osteotomes described as surgical instruments designed to cut and/or shape bone. These devices are typically handheld chisel-like instruments with a sharp distal end that is often beveled on both sides; they are usually stronger than surgical chisels. Dedicated osteotomes are available for several orthopedic, plastic (e.g., nasal), spinal, and oral surgery procedures; they are also used in dentistry.\nConcepts: labradimil (Pharmaceutical Adjuvants)\tIDA assembly (Molecular Function)\tprothylakoid membrane (plastid thylakoid membrane)\tOsteotome (Surgical Instruments)\tGranulin E (Amino Acid, Peptide, or Protein)", + "output": "Osteotome (Surgical Instruments)" + }, + { + "input": "Definition: Molecular Function described as the chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2.\nConcepts: Gastric Neuroendocrine Tumor pNX TNM Finding v8 (Finding)\tOcular Adnexal Lymphoma pT2b TNM Finding v7 (Ocular Adnexal Lymphoma pT2 TNM Finding v7)\tUnit of energy (Quantitative Concept)\tcyclooxygenase pathway (arachidonic acid metabolic process)\tPlexus vesicalis (Autonomic nervous system)", + "output": "cyclooxygenase pathway (arachidonic acid metabolic process)" + }, + { + "input": "Definition: Mass of digestive structure described as a polyp that arises from the stomach. This category includes neoplastic polyps (intestinal-type adenomatous polyps, gastric-type adenomas, and fundic gland polyps), and non-neoplastic polyps (hyperplastic polyps and hamartomatous polyps).\nConcepts: lateral posterior thalamic nucleus (Thalamic Nuclei)\tAnterior staphyloma (Disease or Syndrome)\tGastric polyp (Polyposis, Gastric)\tPhosphorous Acids (Chemical Viewed Structurally)\tOrexin Receptor Antagonists (Pharmacologic Substance)", + "output": "Gastric polyp (Polyposis, Gastric)" + }, + { + "input": "Definition: Pharmacologic Substance described as a dopamine agonist and serotonin antagonist. It has been used similarly to BROMOCRIPTINE as a dopamine agonist and also for MIGRAINE DISORDERS therapy.\nConcepts: ncam (Cell Adhesion Molecules)\tDorsolateral Prostate Gland (Experimental Organism Anatomical Concept)\tMycoplasma salivarium Edward 1955 (Mycoplasma)\tKemerovo Virus (Kemerovo virus subgroup)\tMETERGOLINE (Pharmacologic Substance)", + "output": "METERGOLINE (Pharmacologic Substance)" + }, + { + "input": "Definition: Habit and impulse disorder described as a disorder characterized by the recurrent failure to resist the impulse to steal items of little intrinsic value; the individual experiences a rising subjective sense of tension before the theft and a sense of gratification or relief during the theft.\nConcepts: physiology (Thesaurus of Psychological Index Terms)\tepigen protein, human (Amino Acid, Peptide, or Protein)\tAutoimmune Adrenalitis (Disease or Syndrome)\tnegative regulation of fever generation (Organism Function)\tPathological stealing (Habit and impulse disorder)", + "output": "Pathological stealing (Habit and impulse disorder)" + }, + { + "input": "Definition: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen described as catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene.\nConcepts: negative regulation of adenosine 3',5'-cyclophosphate-dependent protein kinase activity (Cell Function)\tReligious Philosophy (Religion)\tDifluoromethylornithine (Other agents against leishmaniasis and trypanosomiasis in ATC)\tD-lactate dehydrogenase (cytochrome c-553) activity (oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor)\tlimonene monooxygenase activity (Molecular Function)", + "output": "limonene monooxygenase activity (Molecular Function)" + }, + { + "input": "Definition: Pharmacologic Substance described as a nutritional supplement comprised of prebiotic and probiotic ingredients, with potential immunomodulating and gastrointestinal (GI) flora-restoring activity. Upon ingestion of the synbiotic supplement, the prebiotics and probiotics work synergistically in the GI tract, thereby modulating the GI flora ecosystem and may improve the functions of the intestinal barrier. In addition, synbiotics may have a beneficial effect on the immune system. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C99230\" active clinical trials using this agent.\nConcepts: FAC04205 (Intellectual Product)\tDisorder, Colony Collapse (Pathologic Function)\tup-regulation of cellular alcohol catabolic process (regulation of cellular alcohol catabolic process)\tSynbiotic Supplement (Pharmacologic Substance)\tsnRNP, U7 (Amino Acid, Peptide, or Protein)", + "output": "Synbiotic Supplement (Pharmacologic Substance)" + }, + { + "input": "Definition: unclassified Siluriformes described as common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.\nConcepts: 5'-Chloro-2-(p-((5-isobutyl-2-pyrimidinyl)sulfamoyl)phenyl)-o-acetanisidide Monosodium Salt (Pharmacologic Substance)\tWD40 and FYVE Domain Containing 2 (Amino Acid, Peptide, or Protein)\tIPSS High Risk (IPSS Risk Category)\tconfined space (Physical Object)\tcatfish (Class osteichthyes - bony fish)", + "output": "catfish (Class osteichthyes - bony fish)" + }, + { + "input": "Definition: Arbitrary Unit of Substance Rate described as a unit of substance (biologic activity) flow rate equal to one international unit per day.\nConcepts: mTOR Kinase Inhibitor OSI-027 (Pharmacologic Substance)\tTranslational Research (Research Activities)\tPlanned Activity Blinded Description (Blinded Description)\tinternational unit/day (Quantitative Concept)\ttopical vitamin E (Clinical Drug)", + "output": "international unit/day (Quantitative Concept)" + }, + { + "input": "Definition: Knowledge acquisition described as to form by instruction, discipline, or drill; to teach so as to make fit, qualified, proficient or prepared.\nConcepts: Functional training (healthcare operations)\tDLQI110 (Intellectual Product)\tColoAd1 oncolytic virus (Oncolytic Viruses)\tNerve of pharyngeal arch (Embryonic Structure)\ttransforming growth factor beta receptor signaling pathway involved in primitive streak formation (TGF-Beta Receptor Signaling Pathway)", + "output": "Functional training (healthcare operations)" + }, + { + "input": "Definition: G protein-coupled nucleotide receptor binding described as interacting selectively and non-covalently with a P2Y8 nucleotide receptor.\nConcepts: 11q22.2-q22.3 (Chromosome band)\tPerformed Administrative Activity Variance Type Code (Intellectual Product)\tPerformed Observation Result Comment (Published Comment)\tP2Y8 nucleotide receptor binding (Molecular Function)\tDiabetes risk (Disease susceptibility)", + "output": "P2Y8 nucleotide receptor binding (Molecular Function)" + }, + { + "input": "Definition: something described as any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.\nConcepts: down regulation of histone deacetylation (Molecular Function)\tMedicinal gas (Basic Dosage Form Category)\tSoft Tissue Sarcoma of the Retroperitoneum pT3 TNM Finding v8 (Soft Tissue Sarcoma of the Retroperitoneum Pathologic Primary Tumor TNM Finding v8)\tichthyosis-characteristic appearance-mental retardation syndrome (Disease or Syndrome)\tphosphatidylinositol-mediated signaling (Molecular Function)", + "output": "down regulation of histone deacetylation (Molecular Function)" + }, + { + "input": "Definition: Lungs and Breathing described as the significant impairment of gas exchange resulting in hypoxia and/or hypercarbia, to the extent that tissue oxygenation is severely compromised.\nConcepts: diphtheria, pertussis, tetanus/Bacille Calmette-Guerin/measles/Serratia/pneumococcus vaccine (Immunologic Factor)\tphrenic nerves (Mediastinum)\tregulation of ascospore wall beta-glucan biosynthetic process (regulation of ascospore formation)\tStructure of pelvic blood vessel (Abdominal blood vessel)\tFailure respiratory (Dyspnea)", + "output": "Failure respiratory (Dyspnea)" + }, + { + "input": "Definition: Cell Function described as any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL.\nConcepts: specialties medical (Medicine)\tUse Aid or Device for Activity (Clinical or Research Assessment Question)\tIntracorneal use (Ophthalmic Route of Drug Administration)\tliterature survey (Publications)\tregulation of FasL synthesis (regulation of glycoprotein biosynthetic process)", + "output": "regulation of FasL synthesis (regulation of glycoprotein biosynthetic process)" + }, + { + "input": "Definition: something described as a specific inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta, with potential antineoplastic and chemo/radiosensitizing activities. Upon oral administration, Hsp90alpha/beta inhibitor TAS-116 specifically binds to and inhibits the activity of Hsp90 alpha and beta; this results in the proteasomal degradation of oncogenic client proteins, which inhibits client protein dependent-signaling, induces apoptosis, and inhibits the proliferation of cells overexpressing HSP90alpha/beta. Hsp90, a family of molecular chaperone proteins that are upregulated in a variety of tumor cells, plays a key role in the conformational maturation, stability, and function of \"client\" proteins within the cell,; many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, cell-cycle regulators, transcription factors and hormone receptors. As TAS-116 selectively inhibits cytosolic HSP90alpha and beta only and does not inhibit HSP90 paralogs, such as endoplasmic reticulum GRP94 or mitochondrial TRAP1, this agent may have less off-target toxicity as compared to non-selective HSP90 inhibitors. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C134448\" active clinical trials using this agent.\nConcepts: Stage II Intrahepatic Bile Duct Cancer (Neoplastic Process)\taddiction psychological (Alcohol or other drugs dependence)\tLaurencia Lamouroux, 1813: 130 (Rhodophyta)\tTAS-116 (Organic Chemical)\tBreeding, Selective (Genetic Function)", + "output": "TAS-116 (Organic Chemical)" + }, + { + "input": "Definition: Disease or Syndrome described as inflammation of the liver resulting from ingestion of alcohol.\nConcepts: Hepatitis, Alcoholic (Disease of liver and bile duct)\tFunction, Atrial (Organ or Tissue Function)\tnucleolar exosome (nuclear exosome)\tMSQL110 (Intellectual Product)\tCD354 Antigen (Membrane Glycoproteins)", + "output": "Hepatitis, Alcoholic (Disease of liver and bile duct)" + }, + { + "input": "Definition: Amino Acid, Peptide, or Protein described as a protein encoded by the ARHGEF5 gene.\nConcepts: ASSG0101 (ASSIGN Score Clinical Classification Question)\tTreponema Pallidum Associated Congenital Nephrotic Syndrome (Nephrosis, congenital)\tARHGEF5 Gene Product (Amino Acid, Peptide, or Protein)\tdTDP-4-dehydro-6-deoxyglucose reductase activity (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)\tCLIP, IRIS RETRACTOR (Medical Device)", + "output": "ARHGEF5 Gene Product (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: Tracking code use with or without ICD diagnosis described as mapping the practitioner type or specialty to a cancer, oncology or brachytherapy service or procedure code. Use associated HCPCS II codes to bill for cancer, oncology or brachytherapy service(s). This code is used for scope-of-practice mapping, not for billing.\nConcepts: Smoker's melanosis (Melanosis of mucosa of body orifice)\tUnderdeveloped crus of the ear (Abnormality of the crus of the helix)\tPredictive Value, Negative (Quantitative Concept)\tIVD Test Reagent/Kits, Immunohematology, Blood Grouping, ABO Typing, Sera (IVD Test Reagent/Kits, Immunohematology, Blood Grouping, ABO Typing)\tNnspcfd HCPCS cancer/onc/brc (Health Care Activity)", + "output": "Nnspcfd HCPCS cancer/onc/brc (Health Care Activity)" + }, + { + "input": "Definition: something described as a portion of the superior temporal gyrus near the temporal pole in the human. It is located in the temporal bank of the lateral fissure rostral to the transverse temporal gyrus ( Szikla-1977 ).\nConcepts: Planum Polare (Body Part, Organ, or Organ Component)\tCK2-targeting synthetic peptide CIGB-300 (Amino Acid, Peptide, or Protein)\tOxygen Canister/IV Pole Holders, Wheelchair (Bag, device)\tnegative regulation of protein S-nitrosylation (Molecular Function)\tBladder Cancer pT3 TNM Finding v6 and v7 (Finding)", + "output": "Planum Polare (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Gene or Genome described as this gene plays a role in RAC1 activation.\nConcepts: Localised slight acute periodontitis (Oral lesion)\tDNF15S2 (Gene or Genome)\tIVL wt Allele (IVL gene)\tRHO GTPase-ACTIVATING PROTEIN 22 (Gene or Genome)\tMGST2 (Transferase Gene)", + "output": "RHO GTPase-ACTIVATING PROTEIN 22 (Gene or Genome)" + }, + { + "input": "Definition: something described as nasal cavity and paranasal sinuses cancer with metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-).\nConcepts: budding cell bud growth (Reproductive process)\tCell Division Cycle Genes (Genes)\tceramidase activity (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides)\tGrade 2 Vasculitis (Vasculitis, CTCAE)\tNasal Cavity and Paranasal Sinuses Cancer pN1 TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Pathologic Regional Lymph Nodes TNM Finding v8)", + "output": "Nasal Cavity and Paranasal Sinuses Cancer pN1 TNM Finding v8 (Nasal Cavity and Paranasal Sinuses Cancer Pathologic Regional Lymph Nodes TNM Finding v8)" + }, + { + "input": "Definition: Phenylpiperazine antidepressant described as a kind of depression treatment drug\nConcepts: trazodone (Organic Chemical)\tManufacture, Recombinant Protein (Laboratory Procedure)\tTombusviridae (Plant Viruses)\tPHQ0307C (PHQ Screener Version Questionnaire Question)\tisradipine (Dihydropyridine Calcium Channel Blocker [EPC])", + "output": "trazodone (Organic Chemical)" + }, + { + "input": "Definition: Therapeutic or Preventive Procedure described as surgical incision made in the esophageal sphincter to allow easier passage of food and liquids into the stomach.\nConcepts: Heller's Myotomy (Digestive System Surgical Procedures)\tHave Pins and Needles in Your Arm (Intellectual Product)\tPeritoneal Surface Disease (Other Finding)\tSGRQ Past 3 Months Version - How Many Good Days You Had (St George's Respiratory Questionnaire Past 3 Months Version Questionnaire Question)\tPAN3 (Gene or Genome)", + "output": "Heller's Myotomy (Digestive System Surgical Procedures)" + }, + { + "input": "Definition: Neoplastic Process described as a rare undifferentiated pleomorphic sarcoma that occurs in the penis.\nConcepts: AIDS-Related Kaposi Sarcoma I1 (AIDS-Related Kaposi Sarcoma I (Immune System) Status)\tCalendula Ointment (Pharmacologic Substance)\tCell Response Index (Research Activity)\tleft main stem (Coronary artery)\tPenile Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma)", + "output": "Penile Undifferentiated Pleomorphic Sarcoma (Malignant Fibrous Histiocytoma)" + }, + { + "input": "Definition: Postoperative Complications described as pain during the period after surgery.\nConcepts: Neuroblastoma RAS Viral (v-ras) Oncogene Homolog c.181 182CA>AG (Cell or Molecular Dysfunction)\tsteroid delta-isomerase activity (Molecular Function)\tNetrin (Amino Acid, Peptide, or Protein)\tpost-operative pain (Persistent pain following procedure)\tlung pattern specification process (Organ or Tissue Function)", + "output": "post-operative pain (Persistent pain following procedure)" + }, + { + "input": "Definition: Psychology, Social described as the separation of individuals or groups resulting in the lack of or minimizing of social contact and/or communication; this separation may be accomplished by physical separation, by social barriers or by psychological mechanisms; in the latter, there may be interaction but no real communication.\nConcepts: type II TGF-beta receptor activity (Molecular Function)\tVentilators, Intensive Care, Neonatal/Pediatric, High-Frequency (Ventilators, Intensive Care, Neonatal/Pediatric)\tTelephone Number Type (DataType)\tInterventional Study Design (Research Activity)\tisolation/deprivation (Psychology, Social)", + "output": "isolation/deprivation (Psychology, Social)" + }, + { + "input": "Definition: Benign neoplasm of intra-abdominal organs described as a non-metastasizing neoplasm that arises from the prostate. Representative examples include benign phyllodes tumor, leiomyoma, and fibroma.\nConcepts: Postpartum Recovery (Reproductive process)\tEuropean Directorate for the Quality of Medicines and HealthCare Pharmaceutical Dosage Form (EDQM Health Care Terminology)\tBenign neoplasm prostate (Benign neoplasm of intra-abdominal organs)\tHAMD3TC (Intellectual Product)\tsomatic dysfunction of cervical region (Somatic dysfunction)", + "output": "Benign neoplasm prostate (Benign neoplasm of intra-abdominal organs)" + }, + { + "input": "Definition: something described as a group of East Low Franconian language varieties spoken in the Belgian and Dutch provinces both named Limburg and some neighboring areas of Germany.\nConcepts: Constant Time Delay (Teaching & Teaching Methods)\thippocampal mossy fiber to CA3 synapse (Body Space or Junction)\tSomatolactotropinoma (Neoplastic Process)\tHamster Uterine Leiomyosarcoma (Hamster Neoplasm)\tLimburgish (West Germanic Language)", + "output": "Limburgish (West Germanic Language)" + }, + { + "input": "Definition: Microbiology procedure described as the determination of the amount of Neisseria gonorrhoeae present in a sample.\nConcepts: Benign Tumor of the Adult Brain (Neoplastic Process)\tASP4132 (Antineoplastic Agents)\tAurum muriaticum natronatum / double chloride of gold and sodium / sodium chloroaurate (Inorganic Chemical)\tNGO (Laboratory Procedure)\tDNA Synthesis Induction (Genetic Function)", + "output": "NGO (Laboratory Procedure)" + }, + { + "input": "Definition: Biologically Active Substance described as microsomal triglyceride transfer protein large subunit (894 aa, ~99 kDa) is encoded by the human MTTP gene. This protein plays a role in the targeting of triglycerides, cholesteryl esters, and phospholipids to membranes or vesicles.\nConcepts: Staphylococcus caprae (Staphylococcus, coagulase negative)\t1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl- (Drug allergens)\tMicrosomal Triglyceride Transfer Protein Large Subunit (Biologically Active Substance)\tDRRI-2 - L: Unable to Help Family If Crisis (Intellectual Product)\tPachygyria with cortical thickness > 10 mm perisylvian predominant (Congenital Abnormality)", + "output": "Microsomal Triglyceride Transfer Protein Large Subunit (Biologically Active Substance)" + }, + { + "input": "Definition: something described as a substructure of the thalamus. It, the Nucleus pulvinaris ventralis (Hassler) and the Nucleus pulvinaris suprabrachialis (Hassler) constitute the inferior pulvinar nucleus ( Mai-1997 ).\nConcepts: ECV - Ext cephalic version (Therapeutic or Preventive Procedure)\tHyperamylasaemia (Pathologic Processes)\tNucleus pulvinaris intergeniculatus (Body Part, Organ, or Organ Component)\tpost-embryonic forelimb morphogenesis (forelimb morphogenesis)\tGLUCPE (Laboratory Procedure)", + "output": "Nucleus pulvinaris intergeniculatus (Body Part, Organ, or Organ Component)" + }, + { + "input": "Definition: Experimental Organism Anatomical Concept described as the largest of the ethmoidal nasal turbinates, extending from the ethmoidal crest into the middle of the nasal cavity.\nConcepts: canavanase activity (Molecular Function)\tIntraocular instillation solution (Biomedical or Dental Material)\tHGFR c.1915A>C (Cell or Molecular Dysfunction)\tloop of Henle development (Organ or Tissue Function)\tMedial Nasal Turbinate (Experimental Organism Anatomical Concept)", + "output": "Medial Nasal Turbinate (Experimental Organism Anatomical Concept)" + }, + { + "input": "Definition: something described as a chromosome band present on 7q\nConcepts: 7q21.3 (Cell Component)\tupregulation of peripheral T cell tolerance induction (positive regulation of peripheral tolerance induction)\tRNA polymerase V core binding (RNA polymerase core enzyme binding)\tNational Center for Health Statistics, U.S. (Centers for Disease Control and Prevention)\tcoronary aneurysm (Chronic myocardial ischemia)", + "output": "7q21.3 (Cell Component)" + }, + { + "input": "Definition: something described as functional Assessment of Cancer Therapy-Bone Marrow Transplant Version 4 - I am satisfied with my sex life.\nConcepts: Q-LES-Q-SF - Sex Drive, Interest, Performance (Q-LES-Q-SF Questionnaire Question)\tGrief Work Facilitation: Perinatal Death (mental health counseling)\tFAC061-I Am Satisfied With My Sex Life (FACT-BMT Version 4 Questionnaire Question)\tNHL, lymphoblastic metastatic childhood (stage III and IV childhood lymphoblastic lymphoma)\tSecondary Ion Mass Spectrometry (Mass Spectrometry)", + "output": "FAC061-I Am Satisfied With My Sex Life (FACT-BMT Version 4 Questionnaire Question)" + }, + { + "input": "Definition: Anatomical Abnormality described as abnormally anterior positioning of the infraorbital and perialar regions, or increased convexity of the face, or increased nasolabial angle. The midface includes the maxilla, the cheeks, the zygomas, and the infraorbital and perialar regions of the face\nConcepts: Neurotransmitter Reuptake Inhibitors (Pharmacologic Substance)\tIDH1 NP 005887.2:p.R119Q (IDH1 Protein Variant)\tMidfacial excess (Abnormality of the midface)\tPediatric Quality of Life Neuromuscular Module Acute Version 3 Teen Parent Report Questionnaire Test Code (CDISC Questionnaire Terminology)\tPHQ02-Trouble Sleeping (PHQ-15 Questionnaire Question)", + "output": "Midfacial excess (Abnormality of the midface)" + }, + { + "input": "Definition: Cell Function described as the directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.\nConcepts: Have Skin Tightness (Intellectual Product)\tfluid transport (Cell Function)\tSecondary Hypoadrenalism (Anterior hypopituitarism)\tarea 24 of Brodmann (Brodmann area)\tNote (Document type)", + "output": "fluid transport (Cell Function)" + }, + { + "input": "Definition: regulation of melanin biosynthetic process described as any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of melanin.\nConcepts: negative regulation of melanin formation (Molecular Function)\tFAC075TC (CDISC Questionnaire Terminology)\tHRQOL (Perceived quality of life)\tGrade 1 Intraoperative ocular injury (Finding)\tGrade 3 Hiccups (Hiccups, CTCAE)", + "output": "negative regulation of melanin formation (Molecular Function)" + }, + { + "input": "Definition: something described as repeating a prior procedure to correct or improve the results\nConcepts: AML with t(5;11)(q35;p15); NUP98-NSD1 (Neoplastic Process)\tIDL Cholesterol and VLDL Cholesterol Subtype 3 Measurement (Lipids measurement)\tDynein arms (ATPases Associated with Diverse Cellular Activities)\tRevision, NOS (Surgical revision)\tPresume (Qualitative Concept)", + "output": "Revision, NOS (Surgical revision)" + }, + { + "input": "Definition: Renal parenchyma described as the basic structural and functioning unit of the kidney. It is composed of the glomerulus, where waste products are filtered from the blood, the proximal and distal tubules, the loop of Henle, and the collecting ducts, where urine is produced for excretion from the body.\nConcepts: adenocarcinomas (Glandular cell neoplasm)\tfunctional unit of the kidney (Renal Tissue)\tData Interface Units (Information/Telecommunications Systems)\tDeviation of the ring finger (Abnormal 4th finger morphology)\tD/KM-1, ANTIGEN, ANTISERUM, CONTROL (Indicator, Reagent, or Diagnostic Aid)", + "output": "functional unit of the kidney (Renal Tissue)" + }, + { + "input": "Definition: Enterobacteriaceae described as a genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that utilizes citrate as a sole carbon source. It is pathogenic for humans, causing enteric fevers, gastroenteritis, and bacteremia. Food poisoning is the most common clinical manifestation. Organisms within this genus are separated on the basis of antigenic characteristics, sugar fermentation patterns, and bacteriophage susceptibility.\nConcepts: Antipyretic (Anti-Inflammatory Agents)\tregulation of cell-substrate junction assembly (regulation of cell-substrate junction organization)\tair cleaner (Device Component or Accessory)\tsalmonella (Enterobacteriaceae)\taugmentation procedure (Clinical actions A - G)", + "output": "salmonella (Enterobacteriaceae)" + }, + { + "input": "Definition: Cation Transport Proteins described as a zinc efflux transporter highly expressed by ISLET CELLS of the pancreas. It functions in the accumulation of zinc in intracellular vesicles and may be involved in INSULIN maturation and storage processes. Variations in the SLC30A8 gene are associated with susceptibility to DIABETES MELLITUS, TYPE 2.\nConcepts: Grade 2 Sinusoidal obstruction syndrome (Sinusoidal Obstruction Syndrome, CTCAE)\tNon-negative Integer to Non-negative Integer Ratio Data Type (Intellectual Product)\tSIB - Self-injurious behavior (Behavior)\tZnT 8 Protein (Amino Acid, Peptide, or Protein)\tDistal trisomy 8q (Disease or Syndrome)", + "output": "ZnT 8 Protein (Amino Acid, Peptide, or Protein)" + }, + { + "input": "Definition: CRQ-SAS First Administration Version Questionnaire Question described as chronic Respiratory Questionnaire Self-Administered Standardized Format First Administration Version Questionnaire (CRQ-SAS First Administration Version) In general, how much of the time during the last 2 weeks have you felt frustrated or impatient?\nConcepts: Fixed Cryogenic Vessel (Medical Devices)\tCRQ0106 (CRQ-SAS First Administration Version Questionnaire Question)\tBuy (Activity)\tGrade 3 Esophagitis, CTCAE (Esophagitis, CTCAE)\tCBX5 Gene (Gene or Genome)", + "output": "CRQ0106 (CRQ-SAS First Administration Version Questionnaire Question)" + }, + { + "input": "Definition: Drying Method described as any drying operation not elsewhere described.\nConcepts: Moderately Differentiated Colorectal Adenocarcinoma (Neoplastic Process)\tAnejaculation (Male coital disorder)\tHHLA2 wt Allele (HHLA2 gene)\tSTIMPARM (electrode)\tDrying Method, Not Otherwise Specified (Laboratory Procedure)", + "output": "Drying Method, Not Otherwise Specified (Laboratory Procedure)" + }, + { + "input": "Definition: Histone Deacetylase Complexes described as a histone deacetylase complex that contains a core of four proteins -- Clr1, Clr2, Clr3, and Mit1 in fission yeast -- and localizes to all heterochromatic regions in the genome as well as some euchromatic sites. The complex is involved in regulating nucleosome positioning to assemble higher-order chromatin structures.\nConcepts: SHREC complex location (transcription repressor complex)\tFAT3 wt Allele (Gene or Genome)\tSolid adenocarcinoma with mucin formation (Primary malignant neoplasm)\tPOSTANESTHESIA NURS (Biomedical Occupation or Discipline)\tHypoascorbemia (Vascular Hemostatic Disorders)", + "output": "SHREC complex location (transcription repressor complex)" + }, + { + "input": "Definition: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen described as catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.\nConcepts: MESDC2/SENP1 Fusion Gene (Gene or Genome)\tFAC030-Worry My Condition Will Get Worse (Intellectual Product)\tarachidonate omega6 lipoxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)\ttechnetium Tc 99m-3PRGD2 (Indicator, Reagent, or Diagnostic Aid)\tVocational Training (Educational process of instructing)", + "output": "arachidonate omega6 lipoxygenase activity (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)" + }, + { + "input": "Definition: Biomedical or Dental Material described as solid preparation for veterinary use consisting of one or more powders intended to be dissolved in the specified liquid to obtain a dip solution.\nConcepts: Powder for dip solution (Biomedical or Dental Material)\tLYMCLF (Cell Count)\tmagnetoception, sensory transduction of electrical stimulus (detection of electrical stimulus involved in sensory perception)\tIMD3 (tumor necrosis factor family gene)\tCNS, glioblastoma (Malignant Glioma)", + "output": "Powder for dip solution (Biomedical or Dental Material)" + }, + { + "input": "Definition: positive regulation of metanephros development described as any process that activates or increases the frequency, rate or extent of mesenchymal cell apoptotic process involved in metanephros development.\nConcepts: positive regulation of mesenchymal cell apoptotic process involved in metanephros development (Cell Function)\tNM 005228.3:c.2298 2299insGCCATA (EGFR Exon 20 Insertion Mutation)\tGrade 2 Exostosis (Exostosis, CTCAE 3.0)\tDIFFER SEMANTIC (Thesaurus of Psychological Index Terms)\tAtrium of the Middle Ear (Ear part)", + "output": "positive regulation of mesenchymal cell apoptotic process involved in metanephros development (Cell Function)" + }, + { + "input": "Definition: something described as a spoon-shaped instrument with a sharp edge.\nConcepts: interleukin-11 receptor binding (Cytokine Receptor Binding)\tAKAP8 in Mitosis Pathway (Cell Cycle Regulation Pathway)\tVFQ25-Self Administered Format - Difficulty Shaving or Styling Hair or Putting On Makeup (VFQ25-Self Administered Format Questionnaire Question)\tRegulatory Subunit RIbeta, Cyclic-AMP-Dependent Protein Kinase (Cyclic AMP-Dependent Protein Kinase Type I)\tcurette (Reusable Devices)", + "output": "curette (Reusable Devices)" + }, + { + "input": "Definition: something described as a result that determining if ulceration exists is not possible.\nConcepts: Electrochemical Technic (Laboratory Procedure)\tComputer-Aided Design/Manufacturing Systems, Orthopedic (Manufactured Object)\tNK1R (G Protein-Coupled Receptor Genes)\tIndeterminate Ulceration (CPTAC Responses)\tcyclic di-GMP signaling (Intercellular Communication Process)", + "output": "Indeterminate Ulceration (CPTAC Responses)" + }, + { + "input": "Definition: Quantitative Concept described as a unit of energy expenditure equal to the ratio of the metabolic rate during physical activity in comparison to a reference metabolic rate.\nConcepts: Clinical Events Domain (Domain)\tMixed hepatic porphyria (Porphyrias, Hepatic)\tPetalum (Plant)\tMetabolic Equivalent of Task (Quantitative Concept)\tPinellia Ten. (Arisaemateae)", + "output": "Metabolic Equivalent of Task (Quantitative Concept)" + }, + { + "input": "Definition: regulation of viral process described as any process that modulates the frequency, rate or extent of viral DNA genome packaging via site-specific sequence recognition.\nConcepts: 4-OHE1 (Steroidal Estrogen)\tAgrobacterium Conn 1942 (Bacterium)\tRAG-1 (Amino Acid, Peptide, or Protein)\tIVD Test Reagent/Kits, Immunoassay, Autoimmune, Thyroid (IVD Test Reagent/Kits, Immunoassay, Autoimmune)\tregulation of viral DNA genome packaging via site-specific sequence recognition (regulation of viral process)", + "output": "regulation of viral DNA genome packaging via site-specific sequence recognition (regulation of viral process)" + }, + { + "input": "Definition: Compensatory head posture described as a tendency to tilt the head towards the right shoulder to compensate for a limitation of eye movement. []\nConcepts: Peroneal Neuropathy (Mononeuropathies)\tAbnormality of anterior ethmoidal artery (Finding)\tHyperventilation (Finding)\tCompensatory head tilt to the right shoulder (Compensatory head posture)\tSmall end part of the index finger (Small epiphyses of the phalanges of the hand)", + "output": "Compensatory head tilt to the right shoulder (Compensatory head posture)" + }, + { + "input": "Definition: something described as a small molecule and prodrug of CWP232204 targeting Src associated in mitosis, of 68 kDa (Sam68 or KHDRBS1), with potential antineoplastic activity. CWP232291 is converted in serum into its active form CWP232204 which binds to Sam68, thereby resulting in the induction of apoptosis in selective cancer cells. Due to the multimodular structure of Sam68, the apoptosis mediated by CWP232204-Sam68 interaction can be attributed to 1) activation of transcription factor NF-kB induced by tumor necrosis factor alpha signaling, 2) alternative splicing of BCL-2 apoptosis gene, driving the balance towards pro-apoptotic as opposed to anti-apoptotic isoforms, 3) down-regulation of the anti-apoptotic protein survivin via Want signaling. Sam68, a KH domain RNA-binding protein belonging to the signal transduction and activation of RNA (STAR) family, plays a key role in various cellular processes including cell cycle progression and apoptosis; it is upregulated in many types of cancer cells and its expression is associated with increased cell proliferation and survival. Check for \"https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C97663\" active clinical trials using this agent.\nConcepts: clinical outcome assessment (Study Outcome Measurement)\tAbout The Same (Disease Qualifier)\tAVLT-REY - List B Word 1 (AVLT-REY Functional Test Question)\tp250 (Gene or Genome)\tSam68 Modulator CWP232291 (Organic Chemical)", + "output": "Sam68 Modulator CWP232291 (Organic Chemical)" + }, + { + "input": "Definition: something described as alzheimer's Disease Assessment Scale-Cognitive CDISC Version (ADAS-Cog CDISC Version) Word recall task word 4 for trial 1, 2, 3.\nConcepts: Teleconferencing (Thesaurus of Psychological Index Terms)\tBehavioral Test (Diagnostic Procedure)\t5% Dexpanthenol Mouthwash (Clinical Drug)\tFryer Oil Filtration Machines (Manufactured Object)\tWord Recall: Word [4] (ADAS-Cog CDISC Version Questionnaire Question)", + "output": "Word Recall: Word [4] (ADAS-Cog CDISC Version Questionnaire Question)" + } + ] +} \ No newline at end of file