* ASH1L* DOT1L* EHMT1, EHMT2, EZH1, EZH2* MLL, MLL2, MLL3, MLL4, MLL5* NSD1* PRDM2* SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2* SETMAR, SMYD1, SMYD2, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, SUV420H1, SUV420H2* GeneReviews/NCBI/NIH/UW entry on Kleefstra Syndrome
Human genes encoding proteins with histone methyltransferase activity include:* ASH1L* DOT1L* EHMT1, EHMT2, EZH1, EZH2* MLL, MLL2, MLL3, MLL4, MLL5* NSD1* PRDM2* SET, SETBP1, SETD1A, SETD1B, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2* SETMAR, SMYD1, SMYD2, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, SUV420H1, SUV420H2=== SET domain-containing lysine-specific ======= Structure ====The structures involved in methyltransferase activity are the SET domain (composed of approximately 130 amino acids), the pre-SET, and the post-SET domains.