Although no clinical trials have been performed evaluating Enbrel therapy in patients with multiple sclerosis, clinical trials of other TNF antagonists in patients with multiple sclerosis have shown increases in disease activity.
Kuigi kliinilised uuringud Enbreliga ei ole hõlmanud sclerosis multiplex’ iga haigeid, on vastavad uuringud teiste TNF antagonistidega näidanud haiguse ägenemist.