When nitric oxide is released in response to sexual stimulation, inhibition of PDE5 by vardenafil results in increased corpus cavernosum levels of cGMP.
Kui lämmastikoksiid vabaneb vastuseks seksuaalsele stimulatsioonile, viib PDE5 inhibeerimine vardenafiili toimel cGMP taseme tõusuni kavernooskehas.