Dosage increase and long-term use of meperidine with APTIVUS co-administered with low dose ritonavir are not recommended due to the increased concentrations of the metabolite normeperidine which has both analgesic activity and CNS stimulant activity (eg seizures).
11 analgeetilist kui KNS stimuleerivat toimet (nt krambid) omava metaboliit normeperidiini kontsentratsioon tõuseb.