In healthy male volunteers and postmenopausal women, intravenous administration of ranitidine caused an increase in ibandronic acid bioavailability of about 20%, probably as a result of reduced gastric acidity.
Tervetel meessoost vabatahtlikel ja menopausijärgses eas naistel põhjustas ranitidiini intravenoosne manustamine ibandroonhappe biosaadavuse suurenemist ligikaudu 20%, seda tõenäoliselt maohappesuse vähenemise tõttu.