After a single dose of rotigotine, binding to melanin-containing tissues (i. e., eyes) in the pigmented rat and monkey was evident, but was slowly cleared over the 14-day observation period.
Ühekordse rotigotiiniannuse järel ilmnes pigmenteeritud rottidel ja ahvidel seondumine melaniini sisaldavate kudedega (st silmadega), mis aga 14- päevase vaatlusperioodi jooksul aeglaselt kadus.