When initiating posaconazole treatment in patients already receiving tacrolimus, the dose of tacrolimus should be reduced (e. g. to about one third of the current dose).
Patsientidel, kes posakonasoolravi alustamisel juba saavad takroliimust, tuleb takroliimuse annust vähendada (nt ühe kolmandiku võrra hetkel manustatavast annusest).