Serious adverse reactions have been reported with the concomitant use of selective serotonin reuptake inhibitors (SSRIs), tricyclic, tetracylic antidepressants and MAO inhibitors as well as with another selective MAO-B inhibitor.
Selektiivsete serotoniini tagasihaarde inhibiitorite (SSRI- de), tritsükliliste ja tetratsükliliste antidepressantide, samuti teise MAO- B inhibiitori samaaegsel kasutamisel MAO inhibiitoritega võivad tekkida ohtlikud kõrvaltoimed.