In patients with chronic hepatitis C that were on stable methadone maintenance therapy and naïve to peginterferon alfa-2b, addition of 1.5 microgram/kg/week of ViraferonPeg subcutaneously for 4 weeks increased R-methadone AUC by approximately 15% (95% Cl for AUC ratio estimate 103 – 128%).
Patsientidel kroonilise C hepatiidiga, kes olid pideval metadooni asendusravil ja polnud varem kasutanud peginterferoon alfa- 2b, tõusis pärast ViraferonPegi nahaalust manustamist 1. 5 mikrogramm/ kg/ nädalas, neljaks nädalaks R- metadooni AUC umbes 15% (95% Cl AUC prognoositava vahemiku 103 - 128% jaoks).