As with other NSAIDs, the use of piroxicam in combination with protective agents (e. g. misoprostol or proton pump inhibitors) must be considered for these at- risk patients.
Sarnaselt teiste MSPVA- tega tuleb ka piroksikaami manustamist riskigrupi patsientidele kaaluda koos seedetrakti protekteerivate ravimitega (nt misoprostool või prootonpumba inhibiitorid).