No dose adjustment is needed for warfarin and similar oral anticoagulant agents when bosentan is initiated but intensified monitoring of INR is recommended, especially during bosentan initiation and the up-titration period.
Bosentaanravi alustamisel pole vajalik varfariini ja muude sarnaste suukaudselt manustatavate antikoagulantide annuste korrigeerimine, kuid siiski soovitatakse hoolikalt jälgida INR- i taset (eriti bosentaanravi alustamisel ja tiitrimisperioodil).