In an embryotoxicity study in the rabbit, a higher incidence of cardiovascular and skeletal malformations was observed at systemic exposure levels below the maximun clinical exposure (AUC).
Jäneste embrüotoksilistes uuringutes ilmnes kardiovaskulaarsete ja skeleti arenguhäirete suurenenud esinemisagedus allpool kliiniliselt maksimaalset annust.