QUADRAMET has an affinity for skeletal tissue and concentrates in areas of bone turnover in intimate association with hydroxyapatite; studies in rats have demonstrated that QUADRAMET is cleared rapidly from the blood and localises to growing areas of bone matrix, specifically the layer of osteoid undergoing mineralisation.
QUADRAMET on afiinne luukoe suhtes ning ta kontsentreerub luupähikute piirkonnas, seondudes kõvasti hüdroksüapatiidiga; uuringud rottidel on näidanud, et QUADRAMET eemaldub kiiresti verest ja lokaliseerub luude kasvupiirkondades, eriti luukoe mineraliseerumise kihis.