Starting dose of 50 IU/ kg 3 times per week by the intravenous route, followed if necessary by a dose increase with 25 IU/ kg increments (3 times per week) until the desired goal is achieved (this should be done in steps of at least four weeks).
Kui on vajalik annuse kohandamine, tuleb seda teha vähemalt 4- nädalaste intervallidega; annust tuleb kohandada igal etapil 25 RÜ/ kg kaupa, 3 korda nädalas kuni soovitud ravivastuse saavutamiseni.