The concomitant systemic administration of phenytoin to patients receiving high-dose busulfan has been reported to increase busulfan clearance, due to induction of glutathion-S-transferase.
On teatatud, et fenütoiini samaaegne süstemaatiline manustamine suures annuses busulfaani saavatele patsientidele suurendas glutatioon- S- transferaasi tekke tõttu busulfaani kliirensit.