Steady state volume of distribution is about 35 l and plasma protein binding is 95% irrespective of the concentration and is not modified with age and in patients with renal impairment but the free fraction is doubled in patients with hepatic impairment.
Seda ei mõjuta iga ega neerukahjustus, kuid vaba fraktsioon kahekordistub maksakahjustusega patsientidel.