However, as dosage adjustments for zidovudine may be necessary, it is recommended that separate preparations of lamivudine and zidovudine be administered to patients with severe hepatic impairment.
Kuna vajalik võib olla zidovudiini annuse korrigeerimine, soovitatakse raske maksakahjustusega patsientidel asendada kombineeritud preparaat lamivudiini ja zidovudiini eraldi manustamisega.