During continuous treatment with methylprednisolone, the AUC of methylprednisolone may decrease at later time points within 2 weeks following initiation of dosing with EMEND, due to the inducing effect of aprepitant on CYP3A4.
Pideva ravi puhul metüülprednisolooniga võib selle AUC väheneda edasise 2 nädala jooksul pärast EMEND- ravi alustamist aprepitandi CYP3A4 indutseeriva toime tõttu.