But the sequence of amino acids that make up the protein chains in these orthologs can vary significantly. Sometimes the extent of sequence identity between two orthologs can be as low as 25-30%, and yet their folds remain strikingly similar, attesting to the robustness of function to evolutionary change.
但组成这些同源体的蛋白质链的氨基酸序列可以大相径庭。有时，两种同源体的序列一致性程度可以低至只有25—30%，与此同时，它们的折叠却仍保持着极大的相似性，这证明蛋白质功能对进化是鲁棒的。