For example, when the new class of painkillers called Cox-2 inhibitors was introduced, regulators, physicians, and patients were unaware that these drugs could cause heart attacks and strokes. Tens of thousands of innocent patients – perhaps more – suffered such ADR’s before the first two drugs of this class were withdrawn.
例如，在名叫Cox-2的新一类的止痛药被引进之时，监管部门、内科医生和病人都没有意识到这些药品会引发心脏病发作和中风。成千上万的无辜病人——也许还有更多——在这种新一代的两种新药被召回之前承受了ADR’s的痛苦。