Around the turn of the century, the first sequencing of the human genome led to “reverse vaccinology.” This approach, whereby computational analysis of a pathogen’s genome enables identification and screening of a great many more potential vaccine targets than was previously possible, was used in the successful development of a vaccine against meningitis B.
在世纪之交，人类基因组的首次测序带来了“逆向疫苗学”（reverse vaccinology）。这一方法——对病原体基因组进行计算机分析以识别和筛选潜在疫苗目标，数量之大远远超过了以前的可坑范围——被用于乙脑疫苗的成功开发。