Other substances from tobacco smoke – such as monoamine oxidase inhibitors, which have antidepressant effects –reinforce tobacco dependence, but are absent from vaporized nicotine. That may be why PNV user surveys suggest that nicotine is less addictive in its vaporized form.
但尼古丁只是烟草依赖的原因之一。其他烟草烟雾中的物质&mdash;&mdash;比如具有抗抑郁效果的单胺氧化酶抑制物&mdash;&mdash;会加强烟草依赖，但它们在蒸馏尼古丁中是不存在的。这也许就是PNV使用者调查表明蒸馏形式尼古丁致瘾性较低的原因。