The chemical inhibitors used in this treatment target the enzyme polymerase (PARP1), which is normally involved in the repair of DNA single-strand breaks – a common form of spontaneous DNA lesions. Chemical inhibition of the PARP1 protein results in reduced occurrence of these single-strand break repairs.
使用于这种治疗手段的化学抑制剂主要针对聚合酶（PARP1），PARP1通常用于修补DNA的单个碱基断裂——一种常见的自发性DNA损伤。PARP1蛋白质所产生的化学抑制能够减少这些单个碱基断开的发生。