In the late 1990s, anti-vaccine sentiment manifested itself in a backlash against the measles, mumps, and rubella vaccine. Similarly, a 2004 New York Academy of Medicine survey indicated that twice as many people were worried about the side effects of the well-established smallpox vaccine as were concerned about the disease itself.
公众对疫苗的不信任也在很大程度上促成了疫苗生产的衰退。20世纪90年代后期反麻疹、腮腺炎和风疹疫苗情绪甚嚣尘上就是一例。同样，2004年纽约医学科学院一项调查显示担心早已被证明行之有效的天花疫苗副作用的民众是担心疾病本身者的两倍。