The addition of this inhibitor to intensive chemotherapy has dramatically improved the outlook for these children, increasing the rate of three-year event-free survival from 35% to 80%. The development of targeted new agents is likely to affect outcomes for other subtypes of childhood cancer, including anaplastic large-cell lymphoma and other types of leukemias.
在高剂量化疗中添加这种抑制剂已经让患儿的治疗前景显著改善，并将三年无并发症存活率从35%提高到80%。针对性的新药研发可能影响其他儿童癌症亚型的治疗效果，包括间变性大细胞淋巴瘤和其他类型的白血病。