Still, one of the problems with many of the current medications is that, even with treatment, the recurrence of major depression is very high - around 70-80%. This suggests that physiological processes underlying depression - the ones that may also lead to structural changes in the brain - are not being completely arrested, and thus that a new generation of anti-depressant medications is urgently needed.
而当前许多药物的问题之一是，即使伴随着治疗，主导型抑郁症复发的几率仍非常高--大约70-80%。这意味着抑郁症背后的生理过程--那些可能同时引起大脑组织变化的生理过程--没有被完全抑制，因此，我们急需新一代的抗抑郁药。