As with any therapeutic intervention, the most convincing and direct proof of the preventive efficacy of antioxidant supplements requires randomized, controlled clinical trials. Such trials eliminate the problems of participants’ dietary record and controls the effects of both known and unknown confounding factors.
在任何干预研究中，对于补充抗氧化剂的防治效果最有说服力和最直接的证据需要尽心随机和受控的临床试验。这种试验会排除参与者饮食记录上的问题，并且控制所有已知和未知的复杂因素的影响。