And yet, while this strategy has indeed resulted in better outcomes, the acute and long-term morbidity of therapy has been substantial. Children with high-risk cancers who receive dose-intensive chemotherapy have a greater than 80% chance of experiencing at least one severe, life-threatening, or fatal drug-related toxic event over the course of their treatment.
尽管上述策略的确改善了治疗效果，但治疗所引发的急性及长期发病率一直居高不下。罹患高风险癌症并接受高剂量化疗的儿童在治疗期间有超过80%概率会遭受一次以上危及生命或致命的严重药物毒性损伤。