Our models show that in the absence of therapy, cancer cells that haven’t evolved resistance will proliferate at the expense of the less-fit resistant cells. When a large number of sensitive cells are killed, say, by aggressive therapies, resistant types can proliferate unconstrained.
我们的模型显示在不进行任何治疗的情况下，没有抗药性的癌细胞将会战胜不那么健康的抗药细胞。但当敏感细胞被积极的治疗手段大量杀死的时候，那么抗药细胞就会不受限制地大量扩散。这意味着高剂量化疗实际可能会使进一步治疗无效的几率加大。