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Please login or sign up for a free trial to access the full content.18.8.22.6.1.3 Method 3: From Carbonyl Compounds, Cyanide Salts, and Ammonium Carbonate (Bucherer–Bergs Synthesis)
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Kubik, S., Science of Synthesis Knowledge Updates, (2013) 3, 271.
The Bucherer–Bergs synthesis provides one of the most direct methods for the preparation of hydantoins. It involves the reaction of a ketone or aldehyde with a cyanide salt, ammonia, and carbon dioxide (conveniently generated from ammonium carbonate) and directly produces the hydantoin via an imine (Scheme 84). It is highly practical and new applications of this reaction continue to be developed.[230–233]
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References
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