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Please login or sign up for a free trial to access the full content.1.2.1.1 Third Component 1,3-Dicarbonyl Compound (with Ureas: Biginelli Reaction)
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Chebanov, V. A.; Gorobets, N. Yu.; Sedash, Yu. V., Science of Synthesis: Multicomponent Reactions, (2014) 1, 29.
General Introduction
The three-component Biginelli[1] condensation is today one of the most studied multicomponent reactions and is widely used for the construction of diverse molecules containing 3,4-dihydropyrimidin-2(1H)-one and 3,4-dihydropyrimidine-2(1H)-thione heterocycles [DHPMs; alternative names: 3,4-dihydro-2(1H)-pyrimidin(ethi)ones, 2-(thi)oxo-1,2,3,4-tetrahydropyrimidines]. To date there are more than 1000 publications on the Biginelli reaction and the number of reviews concerning this multicomponent reaction is approaching 100. Such high research interest is explained by the simple methodology and efficiency of this multicomponent reaction for diversity-oriented and focused synthesis. Furthermore, this reaction and its products are often used as models for testing novel catalytic systems,[2,3] process-intensification techniques,[4–9] methods for separation of enantiomers,[10,11] and other newly introduced chemical technologies.[12,13]
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Me e eeeeeee eeeeeee ee e Meeeeeeee eeeeeeee, eee eee-eee, eeeee-eeeeeeeee eeeeeeeeeeee ee eeeeeeeeeeee, eeeee eeeeeeeeeeee, eee eeee ee eeeeeeeee eeeeeee eeeeeeee 8,8-eeeeeeeeeeeeeeee-8(8M)-eee 8, eeeee eeeeeeeeeeee eeee eee eeeeeeee eeeeeee eee ee eeeeeeee ee eeeeeeeeeeeeeeeee eeee eeeeeee (Meeeee 8).[88]
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Me eee eeeee ee eeeee eeee,[88] eee eeeeeeee eeeee eeeeeeeeeeeee eeeeee ee eee eeeeeee ee eeee eee eeee eeeeeeee eeee eeeee eeeeee eeee ee eeeeeeee; eeeeeee, eee eeeeeeeeeee ee eeeeeeeeeeee eeeeeeeeeeee eeee eeeeeeee 88.8% eeeee ee eeeee 8-eeeeee-8-eee-8-eeeeee-8,8,8,8-eeeeeeeeeeeeeeeeeeee-8-eeeeeeeeeee (8).
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References
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