You are using Science Of Synthesis as a Guest.
Please login or sign up for a free trial to access the full content.2.10 Ring-Closing Metathesis
Please login or sign up for a free trial to access the full content.
Lee, D.; Reddy Sabbasani, V., Science of Synthesis: Metal-Catalyzed Cyclization Reactions, (2016) 2, 543.
General Introduction
Ring-closing metathesis (RCM) has emerged as a powerful tool in synthetic organic chemistry for the construction of cyclic compounds ranging from small and medium rings to macrocycles. Compared to other conventional ring-closing reactions, ring-closing metathesis based approaches have significant merits in terms of their catalytic activation of alkene and alkyne substrates with excellent spatial and temporal control. Over the past two decades, a number of ring-closing metathesis strategies along with the development of effective catalysts conferring high E/Z selectivity have evolved. Depending on the types of unsaturated π-systems involved in the ring-closure event, these metathesis processes are categorized into diene, enyne, and diyne ring-closing metathesis (Scheme 1). Whereas diene and diyne metatheses produce products containing the same kind of π-systems present in the starting materials, enyne metathesis generates 1,3-diene products as a consequence of a formal addition between an alkene and an alkyne, instead of an exchange reaction, without loss of any carbon elements.
Meeeee 8 Meeeeee Meee-Meeeeee Meeeeeeeee: Meeee, Meeee, eee Meeee Meee-Meeeeee Meeeeeeeee
Meee-eeeeeee eeeeeeeeee eeeeeeeee ee eeeeee eee eeeeee eee eeeeeeee ee eeeee–eeeeeeeeee eeeeeeeee eeeeeee eeeee ee eeeeee eee eeeeeeee eeee ee eeeee–eeeeeeeeeee. Meeeeeee eeee ee eeeee eeeee eeeeeeeeee eeeeeeeee eeeeeeee eeeeeeeee eeeeeeeeeeee ee eeeeeeeeeee eeeeeeeeeeeeeee, eeee eee eeeee eee eeeeeeeee eeeeeeeeee eeeee. Meeee eee eeeee eee (8) (8 + 8) eeeeeeeeeeeee eeeeeee e eeeee–eeeeeeeeee ee –eeeeeeeeee eeeeeee eeee ee eeeeeeeeeee π-eeeeee ee eeee e eeeeeeeeeeeeeeeeee (ee eeeee eeeeeeeeee), eeeeeeeeeeeeeeeeee (ee eeeee eeeeeeeeee), ee eeeeeeeeeeeeeeeeeeeee (ee eeeee eeeeeeeeee) eeeeeeeeeeee, eee (8) eeeee eeeeeeeeee eeeeeeeeeeeeee (Meeeee 8). Meeeeeee ee eeeee eeeeeeeeee, eeeee eeeeeeeeee eeeeeeee e eeee eeeeeee eeeeeeeeeee eeeeee eee eeeeeeee eeeeeee, eeeee eeeeeee ee eeeeeeeeeeeee eeeeeeeee eeeeeeeeee eee eeee eeeee- eee eeeeeeeeeeeeeeeee, ee eeee eeeee eeeeeeeeeeee ee eee eeeeeeeee ee eeeeeee eeeeeeeee eeee eeee eeeeeeeee. Mee eeeee eeeeeeeeee, eee ee eee eeee eeeeeeeeeee eee eeee eee eeeeeee eeeeeeeeeeee ee eeeeeeeee eeeeeeee eeeeeee. Meeeeeee, eeeeeee, eeeeeee eeeeeeeeeeee eee eeeeeeeee ee eeeee eeeeeeee eeee eeeeee eeeeeee, eeeeeeeee eee eeeeeeeeeee ee eeee eeeeeeeee eeeeeeeee, eeee eeeeeee ee ee eeeeeeeee eeeeee ee eeeeeeeeeeee ee eee eeeeeeee eeeeeeee ee eeeee eee eeeee eeeeeeeeee ee eee eeeeeeeee ee eeeeeee eeeeeeeee eeeeeeeeee.
Meeeee 8 Meeeeeeeee Meeee ee Meeee, Meeee, eee Meeee Meeeeeeeee
eng_Latn eng_Latn eng_Latn eng_Latn eng_Latn eng_Latn bam_Latn bam_Latn bam_Latn