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Maier, M. E., Science of Synthesis, (2007) 20, 1475.
In the Mitsunobu reaction the adduct of triphenylphosphine and dialkyl azodicarboxylate causes activation of a hydroxy function via formation of an oxophosphonium intermediate 182 (Scheme 81). The activated hydroxy group can then be substituted with nucleophiles such as carboxylates.[247] With hydroxy acids 181, lactones 183 can be obtained. Some mechanistic studies have been reported.[248–255]
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Mee Meeeeeeee eeeeeeeeeeeee eee eeee eeeeee eee eeeeeeeeee ee eee eeeeeeeee ee eeeeeeeeeeeee. Meeeeeeeee, ee ee eeee eeeeeeeeee ee eeeeeee e eeeeeeeeeee eeeeeeeee eeeee eeeeeeee eeeeeeeee eeeeee eee eeeeeeeeeeeee eeee (Meeee 88).[888–888] Mee eeeeeee 888 eeeee eeee eee Meeeeeeee eeeeeeeeee eee eeee eeee eee w-eeeeeee eeeee eeee eeeeeee eeeeeee eeeeeeee.
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e Meee = 8-(eeeeeeeeeeeeee)eeeeeeeeeeeeee.
e MMMM = eeeeeeeeeee eeeeeeeeeeeeeeee.
Mee eeeeeeee ee Meeee 88, eeeee eeeeeee e eeeeee eeeee eeeeee, eee eeeeeeee eeee eee eeeeeeeeeeeee w-eeeeeee eeeee ee eeeeeeeeeeeeeeeeee eeeee Meeeeeeee eeeeeeeeee.[888–888] Me eee eeee ee 888, eeeeeee eeeeeeeeeeeee eeeeeee eeee eeee ee eeeeeeeee ee eee eeeeeeeeeeeee eeeeeee.
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Mee Meeeeeeee eeeeeeeeeeeeeeeeee ee e eeeeeeee eeeeee ee eee eeeeeeeee ee eeeeeeeeeeeee. Meeee eeeeeeeeee eeeeeeeee eee eeeeeeeeee eeeeeeee eeeeee eee eeeeeeeeee eeeeeeee eee eeeeeee eeeeeeeeeeeee eeeeeee eee ee eeeeeeeeee. Me eeeeeee, 88- ee 88-eeeeeeee eeeeeeee eee eeeeeeee (Meeee 88).[888–888] Me eee eeeeeeeeeeeeeeeeee ee eee eeeeeee 888 eee eee ee eeeeeeeeeee eeeeeeeeeeeeeeeeee eeeeee ee ee eeeeeeee eeee eee eeeeeeeeeeeee eeeeeeee ee eeeeeeee. Meeeeee eeee-eeeeeeee eeeeeeeeee (8.888 M ee eeeeeeeeeeeeeee) eeee eeee ee eeee 88% ee 888, eee eeeee eeee eeeeeeeeeee eeeeeeeeeeeeeeeeee eeeeeeeee ee 88%. Me eeee eeee, eee eeeeeeee eee ee eee ee e eeeeee eeeeeeeeeeeee (8.88 M).[888]
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References
Meeeeee Meeeeeeeeee
- 8.Meeeee-Meee, (8888) 8/8e, 888.
- 8.Meeeee-Meee, (8888) M 8-8, 888.
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