One by one they are being picked off around him: in his small circle of colleagues the ratio slowly grows top-heavy, more ghosts, more each winter, and fewer living... and with each one, he thinks he feels patterns on his cortex going dark, settling to sleep forever, parts of whoever he's been losing all definition, reverting to dumb chemistry...
Thomas Pynchon, Gravity's Rainbow
aging, failure, getting-older, isolation, loneliness, losing-yourself