...[R]eason of itself, independent on all experience, ordains what ought to take place, that accordingly actions of which perhaps the world has hitherto never given an example, the feasibility even if which might be very much doubted by one who founds everything on experience, are nevertheless inflexibly commanded by reason; that, for example, even though there might never yet have been a sincere friend, yet not a whit the less is pure sincerity in friendship required of every man...
Immanuel Kant, Fundamental Principles of the Metaphysic of Morals
example, fate, reason, responsibility, science