The effect of hallucinogenic mushrooms on the user's experience and behavior depends in part on his or her personality and genetic predisposition, which can vary to a great extent from person to person. As symptoms of psychiatric disorders can sometimes be elicited after one-off use, people with a genetic tendency to depression or psychosis should be discouraged from using psychoactive mushrooms.
John Rush, Entheogens and the Development of Culture: The Anthropology and Neurobiology of Ecstatic Experience
culture, entheogen, hallucinogenic