We have one real candidate for changing the rules; this is string theory. In string theory the one-dimensional trajectory of a particle in spacetime is replaced by a two-dimensional orbit of a string. Such strings can be of any size, but under ordinary circumstances they are quite tiny, ... a value determined by comparing the predictions of the theory for Newton's constant and the fine structure constant to experimental values.
Edward Witten
constants-of-nature, fine-structure-constant, physics, string-theory