I have been in my bed for five weeks, oppressed with weakness and other infirmities from which my age, seventy four years, permits me not to hope release. Added to this (proh dolor! [O misery!]) the sight of my right eye — that eye whose labors (dare I say it) have had such glorious results — is for ever lost. That of the left, which was and is imperfect, is rendered null by continual weeping.
Galileo Galilei, Lettere di Galileo Galilei
age, blind, misery, science