

Human: How can I keep my legs warm in the winter?

Assistant: I’m not sure if you’re looking for clothes or a specific piece of equipment, but there are a couple things that are common: a pair of pants or a pair of socks that are thicker, and heavier, than what you typically wear.  Also, many people just wear thick, warm pants over whatever else they’re wearing, rather than an all-over outfit.  There are also a few things that can be purchased separately that may help:

-    Boot/sock liners that wick away sweat better, and are lined with materials that hold body heat and don’t let it passively out of your clothing (e.g. wool)

-    A “snuggie” or “ugly Christmas sweater” that you can wear over your clothes to trap warm air close to your skin, and your regular clothes can passively sweat through (i.e. you can wear more than a sweater)

-    Heavy thermal socks or heavy socks worn over regular socks

-    Thick, knitted, long underwear under regular clothing

Human: Great ideas. Do you have more suggestions?

Assistant: A few more, in no particular order:

-    Socks made out of a blend of wool and plastic microfiber fibers, because of their moisture-wicking abilities

-    Spandex fibers are a flexible fiber used in athletic clothing that can help wick away sweat

-    A thin athletic t-shirt or tank-top that will trap sweat close to the body and not let it passively out

-    Any clothes that are layered in a way that help trap warm air close to the body

-    Some people also layer multiple pairs of heavy/thick socks

-    Thick bed-socks or even socks that are designed for inside or sleeping feet, and are thicker

-    Cotton long johns (i.e. underwear)

-    Compression leggings that are designed to hug the body and are often heavier than regular leggings

-    “Two in one” layers, where two pieces of clothing are designed to be worn together

-    One piece of clothing with large areas of spandex that are designed to cover more of the body and trap more warmth

-    A soft hood with no other clothing attached to it (e.g

Human: Okay, but a hood isn't for legs.


Assistant: In my understanding, it is not only possible to cover the whole body except for the tops, although they move your knees and hips a little bit and it will also have the same amount of damage as if you were wearing clothing that moves your knees and hips.  But what’s the argument against being a “bath”, and is it a good idea to get a simple garment with the same number of layers as a clothes (e.g. with a longer t-shirt or tank-tail for the same amount of time it might be better!)

-  It seems to me that there’s a lot more to it than is said by people, so it’s really worth to consider whether this is true for all clothing that we are wearing.

- I read that the wearing of the t-shirts, especially for pants, is necessary to keep the fabric from shrinking (that’s not the case when pants should).  Do you have an idea about how long it’s likely to take to get by wearing t-shirts to keep you warmer? 
-  There are many ways to go about this, but it’s worth to consider this:

-  One way to describe a pants shirt is an act of inchesure (or a good choice by you) with long pants (e.g. a long, thick cotton shirt or long pants that can
-  For a shorter (e.g. shirt that stays comfortable) and a more casual garment with thin pants, a suit, and some of your clothes (e.g. pants. comforias, pants. comforias are very appropriate!)
-  Another way to describe pants is by shaving some cloth and gloves (e.g. shaving shaving wool or fabric, and so forth)
-  Lastly, in a casual garment, the shirt can help reduce heat and moisture in the body and shorten the length of your t-shirt.

-  Another idea in another, perhaps more common, type of fabric, to avoid being so thin (e.g. a slip-on type fabric where you can leave your clothes out to a longer length than you will need to.
-  A fabric with fewer pockets (e.g. fabric with buttons up to three separate pieces)

-  So often when you need
Assistant: A small amount of clothing, not as thick as what it typically is, and not as light as an elastic panty liner.

Fibroblast growth factor 23 (FGF23) is an important downstream regulator of multiple cell types in cancer.
FGF23 (also referred to as FGF23 or EGF-like factor 23), also known as TGFB, regulates the secretion or activity of most major growth factors, whereas TGFB is thought to induce some growth factors and participate in cancer development from the standpoint of cell-cell interactions. The TGFB, or transforming growth factor beta (TGF beta), is a potent mitogen in humans, and is required for the survival, proliferation, and differentiation of tumor cells. Previous findings have revealed a close relationship between FGF23 expression and poor prognosis in breast cancer cells, but little is understood regarding its ability to directly reverse tumorigenesis by reducing TGF beta/FGF signaling. In this study, we used conditional mutant mice genetically engineered to express wild-type or mutant forms of FGF23 (G6PDAS1 and G3PDAS1). We examined the expression of the TGF-beta/FGF23 target gene in the mammary gland and the ability of the mutant cells to invade the mammary stroma, establish primary tumors, and generate a metastatic phenotype. We observed that the expression of both the G6PDAS1- and G3PDAS1-transfected G6PDAS1-expressing cells was severely reduced in the mammary tumor forming cells, indicating that mutation of the TGF-beta receptor-associated signaling domain causes poor cell to tumor formation. Moreover, a decrease in the level of endogenous FGF23 in the G6PDAS1-overexpressing cells was observed, indicating that TGF-beta/FGF23 signaling is not directly responsible for the reduced expression of FGF23. The reduction in G3PDAS1 also resulted in decreased expression of FGF23 in primary tumor forming cells from either wild-type or mutant mice, thus revealing an inverse relationship between the number of cells with high and decreased levels of FGF23 in the mammary gland. Overall, we found no evidence that the increased expression of FGF23 is mediated by the TGF-beta/FGF23 signaling pathway. We propose that the altered expression of FGF23 plays an important role in the tumor development associated with the progression of cancer through modulation of the TGF-beta/FGF signaling