Association between mitral valve prolapse and open-angle glaucoma
Shuo Ju Chiang, Masao Daimon, Li Hsuan Wang, Ming Jui Hung, Nen Chung Chang, Hsiu Chen Lin
Objective Proteoglycans and glycosoaminoglycans play many roles in connective tissue formation, their accumulation in myxomatous tissues may influence the associated mechanical behaviour of the mitral valve, as well as the extracellular matrix of the eye. Open-angle glaucoma (OAG) and mitral valve prolapse (MVP) may share similar phathophysiology. We hypothesised that MVP increased the risk of developing glaucoma. Methods The research was a retrospective cohort study using a longitudinal health insurance database from the National Health Insurance programme. The database was a randomly sampled population of 1 073 891 followed for 13 years from 1996 to 2008. There were 21 677 subjects with MVP, and 86 708 subjects without MVP were propensity score matched and served as a comparison group. Cox proportional hazards analysis was performed and adjusted for several comorbidities to evaluate the adjusted HR for OAG in the MVP group. Results The incidence rate of OAG in patients in the non-MVP and MVP groups were 10.17 and 16.05 per 10 000 person-years, respectively. The adjusted HR for OAG in the MVP group was 1.88 (95% CI 1.58 to 2.23). A significantly elevated risk of OAG in patients with MVP was also identified in the four stratified age groups. The cumulative incidence of OAG was assessed by Kaplan-Meier analysis. The analysis revealed that the MVP group had a higher incidence of OAG than the comparison group during the follow-up period (p
https://doi.org/10.1136/heartjnl-2014-306198
National Health Programs
Propensity Score
Proteoglycans
Chiang, S. J., Daimon, M., Wang, L. H., Hung, M. J., Chang, N. C., & Lin, H. C. (2015). Association between mitral valve prolapse and open-angle glaucoma. Heart, 101(8), 609-615. https://doi.org/10.1136/heartjnl-2014-306198
Association between mitral valve prolapse and open-angle glaucoma. / Chiang, Shuo Ju; Daimon, Masao; Wang, Li Hsuan; Hung, Ming Jui; Chang, Nen Chung; Lin, Hsiu Chen.
In: Heart, Vol. 101, No. 8, 01.04.2015, p. 609-615.
Chiang, SJ, Daimon, M, Wang, LH, Hung, MJ, Chang, NC & Lin, HC 2015, 'Association between mitral valve prolapse and open-angle glaucoma', Heart, vol. 101, no. 8, pp. 609-615. https://doi.org/10.1136/heartjnl-2014-306198
Chiang SJ, Daimon M, Wang LH, Hung MJ, Chang NC, Lin HC. Association between mitral valve prolapse and open-angle glaucoma. Heart. 2015 Apr 1;101(8):609-615. https://doi.org/10.1136/heartjnl-2014-306198
Chiang, Shuo Ju ; Daimon, Masao ; Wang, Li Hsuan ; Hung, Ming Jui ; Chang, Nen Chung ; Lin, Hsiu Chen. / Association between mitral valve prolapse and open-angle glaucoma. In: Heart. 2015 ; Vol. 101, No. 8. pp. 609-615.
@article{f2f20d0abb3e46b584de31df18af1ef1,
title = "Association between mitral valve prolapse and open-angle glaucoma",
abstract = "Objective Proteoglycans and glycosoaminoglycans play many roles in connective tissue formation, their accumulation in myxomatous tissues may influence the associated mechanical behaviour of the mitral valve, as well as the extracellular matrix of the eye. Open-angle glaucoma (OAG) and mitral valve prolapse (MVP) may share similar phathophysiology. We hypothesised that MVP increased the risk of developing glaucoma. Methods The research was a retrospective cohort study using a longitudinal health insurance database from the National Health Insurance programme. The database was a randomly sampled population of 1 073 891 followed for 13 years from 1996 to 2008. There were 21 677 subjects with MVP, and 86 708 subjects without MVP were propensity score matched and served as a comparison group. Cox proportional hazards analysis was performed and adjusted for several comorbidities to evaluate the adjusted HR for OAG in the MVP group. Results The incidence rate of OAG in patients in the non-MVP and MVP groups were 10.17 and 16.05 per 10 000 person-years, respectively. The adjusted HR for OAG in the MVP group was 1.88 (95{\%} CI 1.58 to 2.23). A significantly elevated risk of OAG in patients with MVP was also identified in the four stratified age groups. The cumulative incidence of OAG was assessed by Kaplan-Meier analysis. The analysis revealed that the MVP group had a higher incidence of OAG than the comparison group during the follow-up period (p",
author = "Chiang, {Shuo Ju} and Masao Daimon and Wang, {Li Hsuan} and Hung, {Ming Jui} and Chang, {Nen Chung} and Lin, {Hsiu Chen}",
doi = "10.1136/heartjnl-2014-306198",
journal = "Heart",
T1 - Association between mitral valve prolapse and open-angle glaucoma
AU - Chiang, Shuo Ju
AU - Daimon, Masao
AU - Wang, Li Hsuan
AU - Hung, Ming Jui
N2 - Objective Proteoglycans and glycosoaminoglycans play many roles in connective tissue formation, their accumulation in myxomatous tissues may influence the associated mechanical behaviour of the mitral valve, as well as the extracellular matrix of the eye. Open-angle glaucoma (OAG) and mitral valve prolapse (MVP) may share similar phathophysiology. We hypothesised that MVP increased the risk of developing glaucoma. Methods The research was a retrospective cohort study using a longitudinal health insurance database from the National Health Insurance programme. The database was a randomly sampled population of 1 073 891 followed for 13 years from 1996 to 2008. There were 21 677 subjects with MVP, and 86 708 subjects without MVP were propensity score matched and served as a comparison group. Cox proportional hazards analysis was performed and adjusted for several comorbidities to evaluate the adjusted HR for OAG in the MVP group. Results The incidence rate of OAG in patients in the non-MVP and MVP groups were 10.17 and 16.05 per 10 000 person-years, respectively. The adjusted HR for OAG in the MVP group was 1.88 (95% CI 1.58 to 2.23). A significantly elevated risk of OAG in patients with MVP was also identified in the four stratified age groups. The cumulative incidence of OAG was assessed by Kaplan-Meier analysis. The analysis revealed that the MVP group had a higher incidence of OAG than the comparison group during the follow-up period (p
AB - Objective Proteoglycans and glycosoaminoglycans play many roles in connective tissue formation, their accumulation in myxomatous tissues may influence the associated mechanical behaviour of the mitral valve, as well as the extracellular matrix of the eye. Open-angle glaucoma (OAG) and mitral valve prolapse (MVP) may share similar phathophysiology. We hypothesised that MVP increased the risk of developing glaucoma. Methods The research was a retrospective cohort study using a longitudinal health insurance database from the National Health Insurance programme. The database was a randomly sampled population of 1 073 891 followed for 13 years from 1996 to 2008. There were 21 677 subjects with MVP, and 86 708 subjects without MVP were propensity score matched and served as a comparison group. Cox proportional hazards analysis was performed and adjusted for several comorbidities to evaluate the adjusted HR for OAG in the MVP group. Results The incidence rate of OAG in patients in the non-MVP and MVP groups were 10.17 and 16.05 per 10 000 person-years, respectively. The adjusted HR for OAG in the MVP group was 1.88 (95% CI 1.58 to 2.23). A significantly elevated risk of OAG in patients with MVP was also identified in the four stratified age groups. The cumulative incidence of OAG was assessed by Kaplan-Meier analysis. The analysis revealed that the MVP group had a higher incidence of OAG than the comparison group during the follow-up period (p
U2 - 10.1136/heartjnl-2014-306198
DO - 10.1136/heartjnl-2014-306198
JO - Heart
JF - Heart
10.1136/heartjnl-2014-306198