['A', 'significant', 'drawback', ',', 'for', 'either', 'approach', ',', 'is', 'a', 'dependence', 'on', 'a', 'supply', 'of', 'enantiopure', 'reagents', 'or', 'substrates', '–', 'synthesis', 'routes', 'generally', 'utilise', 'chiral', 'building', 'blocks', 'or', 'enantioselective', 'catalysts', '[', '7,8', ']', ',', 'while', 'enantiomer', 'separation', 'techniques', 'typically', 'incorporate', 'chiral', 'selector', 'molecules', 'to', 'form', 'chemically', 'distinct', 'and', 'distinguishable', 'diastereomeric', 'complexes', '[', '8,9', ']', '.']