autism
As predicted, Caucasian-American and not Italian families display a significant association between autism and PON1 variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P<0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P<0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P<0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P<0.025).
As predicted, Caucasian-American and not Italian families display a significant association between <span class="disease" id="16027737-6-100-106">autism</span> and <span class="gene" id="16027737-6-111-115">PON1</span> variants less active in vitro on the OP diazinon (R192), according to case-control contrasts (Q192R: chi2=6.33, 1 df, P&lt;0.025), transmission/disequilibrium tests (Q192R: TDT chi2=5.26, 1 df, P&lt;0.025), family-based association tests (Q192R and L55M: FBAT Z=2.291 and 2.435 respectively, P&lt;0.025), and haplotype-based association tests (L55/R192: HBAT Z=2.430, P&lt;0.025).