TNBS damage
In Caco2 cell monolayers, we provided mechanistic evidence that SJZDS-induced increased TEER and decreased permeability after TNBS damage, which were mediated through claudin-2 and NF-kB pathway, including the upregulation of claudin-2, decreased activity of NF-kB p65, reduced level of NF-kB p65 and MLCK.