hepatomas
Here, we show that the Wnt/beta-catenin pathway is also involved in the transcriptional regulation of GSTs: GSTm2, GSTm3, and GSTm6 are overexpressed in mouse hepatomas with activating Ctnnb1 (encoding beta-catenin) mutations and in transgenic hepatocytes expressing activated beta-catenin.
Here, we show that the Wnt/beta-catenin pathway is also involved in the transcriptional regulation of GSTs: GSTm2, GSTm3, and GSTm6 are overexpressed in mouse <span class="disease" id="20118494-3-159-168">hepatomas</span> with activating <span class="gene" id="20118494-3-185-191">Ctnnb1</span> (encoding beta-catenin) mutations and in transgenic hepatocytes expressing activated beta-catenin.