dementia
Genetic studies show that a simple duplication of the A? precursor (APP) gene, as occurs in Down syndrome (trisomy 21), with a 1.5-fold increase in expression, can cause dementia with the complete AD associated neuropathology.
Genetic studies show that a simple duplication of the A&beta; precursor (<span class="gene" id="22300406-4-68-71">APP</span>) gene, as occurs in Down syndrome (trisomy 21), with a 1.5-fold increase in expression, can cause <span class="disease" id="22300406-4-170-178">dementia</span> with the complete AD associated neuropathology.