hyperglycemia
Since hyperglycemia-induced mitochondrial superoxide overproduction increases O-linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the transcription factor Sp1, the effect of hyperglycemia and the hexosamine pathway on eNOS was evaluated.
Since <span class="disease" id="11696579-2-6-19">hyperglycemia</span>-induced mitochondrial superoxide overproduction increases O-linked N-acetylglucosamine modification and decreases O-linked phosphorylation of the <span class="gene" id="11696579-2-166-190">transcription factor Sp1</span>, the effect of <span class="disease" id="11696579-2-206-219">hyperglycemia</span> and the hexosamine pathway on eNOS was evaluated.