neuroblastoma
Crizotinib is a dual-specific inhibitor of ALK/Met and inhibits proliferation of neuroblastoma cells harboring R1275Q-mutated ALK or amplified wild-type ALK, but not cells harboring F1174L.
Crizotinib is a dual-specific inhibitor of <span class="gene" id="22588779-10-43-46">ALK</span>/Met and inhibits proliferation of <span class="disease" id="22588779-10-81-94">neuroblastoma</span> cells harboring R1275Q-mutated <span class="gene" id="22588779-10-126-129">ALK</span> or amplified wild-type <span class="gene" id="22588779-10-153-156">ALK</span>, but not cells harboring F1174L.