alopecia
METHODS: First line MCRC patients received every two weeks simplified LV5FU regimen combined with CPT11 at 180 mg/m(2) at C1, increased to 220 mg/m(2) at C2 and to 260 mg/m(2) at C3 and subsequent cycles in the absence of NCI-CTC gr3-4 toxicities other than alopecia or neutropenia.