heart failure
The combination of ACE inhibitor and ARB, independently of the hypotensive effect, improved LV phenotypic change and increased LV endothelin-1 production and collagen accumulation, diastolic dysfunction, and survival in a rat heart failure model more effectively than either agent alone, thereby providing solid experimental evidence that the combination of these 2 agents is more beneficial than monotherapy for treatment of heart failure.
The combination of ACE inhibitor and ARB, independently of the hypotensive effect, improved LV phenotypic change and increased LV <span class="gene" id="11136700-7-130-142">endothelin-1</span> production and collagen accumulation, diastolic dysfunction, and survival in a rat <span class="disease" id="11136700-7-226-239">heart failure</span> model more effectively than either agent alone, thereby providing solid experimental evidence that the combination of these 2 agents is more beneficial than monotherapy for treatment of <span class="disease" id="11136700-7-426-439">heart failure</span>.