carcinogenesis
METHODS: Both BRCA2 alleles were conditionally deleted during development within the pancreatic epithelium by generating Pdx1-Cre; BRCA2(f/f) ("CB") mice; in addition, triple transgenic Pdx1-Cre; BRCA2(f/f); LSL-Trp53(R172H) ("CBP") mice were generated, in order to determine the impact of p53 deregulation on BRCA2-deficient carcinogenesis.