autosomal dominantly inherited skin disorder
Darier's disease (DD) is an autosomal dominantly inherited skin disorder caused by mutations in sarco/endoplasmic reticulum Ca<sup>2+</sup>-ATPase 2 (SERCA2), a Ca<sup>2+</sup>pump that transports Ca<sup>2+</sup>from the cytosol to the endoplasmic reticulum (ER).