RA
Concurrent with evidence of an immune-activation gene signature in MTX-naive RA patients, significant up-regulation of the folate-metabolizing enzymes ?-glutamyl hydrolase and dihydrofolate reductase, as well as the MTX/folate efflux transporters ABCC2 and ABCC5, was observed in the MTX-naive RA group compared to healthy controls.
Concurrent with evidence of an immune-activation gene signature in MTX-naive <span class="disease" id="23897011-6-77-79">RA</span> patients, significant up-regulation of the folate-metabolizing enzymes &gamma;-glutamyl hydrolase and <span class="gene" id="23897011-6-176-199">dihydrofolate reductase</span>, as well as the MTX/folate efflux transporters ABCC2 and ABCC5, was observed in the MTX-naive <span class="disease" id="23897011-6-294-296">RA</span> group compared to healthy controls.