cholestasis
Our findings show that proinflammatory cytokines stimulate the biliary epithelium to generate NO, via NOS2 induction, and that NO causes ductular cholestasis by a RNOS-mediated inhibition of AC and of cAMP-dependent HCO(3)(-) and Cl(-) secretory mechanisms.
Our findings show that proinflammatory cytokines stimulate the biliary epithelium to generate NO, via <span class="gene" id="12612912-5-102-106">NOS2</span> induction, and that NO causes ductular <span class="disease" id="12612912-5-146-157">cholestasis</span> by a RNOS-mediated inhibition of AC and of cAMP-dependent HCO(3)(-) and Cl(-) secretory mechanisms.