SCC
Some of these EGFR-mutated PDXs do not respond to erlotinib: LU1868 containing L858R/T790M mutations, and LU0858 having L858R mutation as well as c-MET gene amplification, both squamous cell carcinoma (SCC).
Some of these EGFR-mutated PDXs do not respond to erlotinib: LU1868 containing L858R/T790M mutations, and LU0858 having L858R mutation as well as <span class="gene" id="22948846-4-146-151">c-MET</span> gene amplification, both <span class="disease" id="22948846-4-177-200">squamous cell carcinoma</span> (<span class="disease" id="22948846-4-202-205">SCC</span>).