DLBCL
We have reported that ON 01910.Na (rigosertib), a multikinase inhibitor, is selectively cytotoxic for DLBCL and induces more hyperphosphorylation and sumoylation of Ran GTPase-activating protein 1 (RanGAP1) in DLBCL cells than in non-neoplastic lymphoblastoid cell line.
We have reported that ON 01910.Na (rigosertib), a multikinase inhibitor, is selectively cytotoxic for <span class="disease" id="27150054-2-102-107">DLBCL</span> and induces more hyperphosphorylation and sumoylation of <span class="gene" id="27150054-2-165-196">Ran GTPase-activating protein 1</span> (<span class="gene" id="27150054-2-198-205">RanGAP1</span>) in <span class="disease" id="27150054-2-210-215">DLBCL</span> cells than in non-neoplastic lymphoblastoid cell line.