glucose intolerance
Following HFHS diet, WT mice displayed moderate increases in 4-hydroxynonenal (HNE)-adducts and carbonyl stress, and a 1.5-fold increase in GPx4 enzyme in both liver and heart, while gpx4 haploinsufficient (GPx4(+/-)) mice had marked carbonyl stress in these organs accompanied by exacerbated glucose intolerance, dyslipidemia, and liver steatosis.
Following HFHS diet, WT mice displayed moderate increases in 4-hydroxynonenal (HNE)-adducts and carbonyl stress, and a 1.5-fold increase in <span class="gene" id="26042203-7-140-144">GPx4</span> enzyme in both liver and heart, while <span class="gene" id="26042203-7-183-187">gpx4</span> haploinsufficient (<span class="gene" id="26042203-7-207-211">GPx4</span>(+/-)) mice had marked carbonyl stress in these organs accompanied by exacerbated <span class="disease" id="26042203-7-293-312">glucose intolerance</span>, dyslipidemia, and liver steatosis.