hepatic steatosis
These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress.
These studies indicate that <span class="gene" id="21321189-8-28-33">SIRT1</span> serves as a negative regulator of UPR signaling in T2DM and that <span class="gene" id="21321189-8-99-104">SIRT1</span> attenuates <span class="disease" id="21321189-8-116-133">hepatic steatosis</span>, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress.