dilated cardiomyopathy
Because a common finding in dilated cardiomyopathy is a reduction in the myofilament-Ca<sup>2</sup><sup>+</sup>response, we hypothesized that b-arrestin signaling would increase myofilament-Ca<sup>2</sup><sup>+</sup>responsiveness in a model of familial dilated cardiomyopathy and improve cardiac function and morphology.