ovarian tumors
We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene SMARCA4 in 75% (9/12) of SCCOHT cases in addition to SMARCA4 protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary ovarian tumors.
We identified germline and somatic inactivating mutations in the SWI/SNF chromatin-remodeling gene <span class="gene" id="24658001-2-99-106">SMARCA4</span> in 75% (9/12) of SCCOHT cases in addition to <span class="gene" id="24658001-2-152-159">SMARCA4</span> protein loss in 82% (14/17) of SCCOHT tumors but in only 0.4% (2/485) of other primary <span class="disease" id="24658001-2-247-261">ovarian tumors</span>.