HCC
We further show that deletion of a single retinoic acid receptor alpha (Rara) allele in a Trim24-null background suppresses HCC development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background Rara expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway.
We further show that deletion of a single <span class="gene" id="18026104-5-42-70">retinoic acid receptor alpha</span> (<span class="gene" id="18026104-5-72-76">Rara</span>) allele in a Trim24-null background suppresses <span class="disease" id="18026104-5-124-127">HCC</span> development and restores wild-type expression of retinoic acid-responsive genes in the liver, thus demonstrating that in this genetic background <span class="gene" id="18026104-5-273-277">Rara</span> expresses an oncogenic activity correlating with a dysregulation of the retinoic acid signaling pathway.