CPVT
Isolated murine ventricular myocytes harbouring a human RyR2 mutation (RyR2(R4496C+/-)) associated with CPVT were investigated in the absence and presence of 1 micromol/L JTV-519 (RyR2 stabilizer) followed by 100 micromol/L ouabain intervention to increase cytosolic [Na(+)] and SR Ca(2+) load.
Isolated murine ventricular myocytes harbouring a human <span class="gene" id="20080988-4-56-60">RyR2</span> mutation (<span class="gene" id="20080988-4-71-75">RyR2</span>(R4496C+/-)) associated with <span class="disease" id="20080988-4-104-108">CPVT</span> were investigated in the absence and presence of 1 micromol/L JTV-519 (<span class="gene" id="20080988-4-180-184">RyR2</span> stabilizer) followed by 100 micromol/L ouabain intervention to increase cytosolic [Na(+)] and SR Ca(2+) load.