RCC
By comparison to much lower reported VHL mutation frequencies of 33-55% in TRI-unexposed RCC patients, these results indicate a specifically high mutation frequency at the VHL gene in TRI-exposed RCC patients; four of these aberrations have thus far been confirmed as VHL mutations by sequence analysis.
By comparison to much lower reported VHL mutation frequencies of 33-55% in TRI-unexposed <span class="disease" id="9137812-6-89-92">RCC</span> patients, these results indicate a specifically high mutation frequency at the <span class="gene" id="9137812-6-172-175">VHL</span> gene in TRI-exposed <span class="disease" id="9137812-6-196-199">RCC</span> patients; four of these aberrations have thus far been confirmed as VHL mutations by sequence analysis.