acute promyelocytic leukemia
Expression of PML-RAR? fusion proteins disrupted PML-NB structure and reduced HRR by up to 10-fold, raising the possibility that defective HRR and resulting genomic instability may figure in the pathogenesis, progression and relapse of acute promyelocytic leukemia.
Expression of <span class="gene" id="22213200-10-14-17">PML</span>-RAR&alpha; fusion proteins disrupted <span class="gene" id="22213200-10-49-52">PML</span>-NB structure and reduced HRR by up to 10-fold, raising the possibility that defective HRR and resulting genomic instability may figure in the pathogenesis, progression and relapse of <span class="disease" id="22213200-10-236-264">acute promyelocytic leukemia</span>.