HCC
To address the role of IKK2-mediated NF-?B activation in hepatocytes in the pathogenesis of liver disease and HCC in Mdr2(-/-) mice, we generated Mdr2-deficient animals lacking IKK2 specifically in hepatocytes using the Cre-loxP system.
To address the role of IKK2-mediated NF-&kappa;B activation in hepatocytes in the pathogenesis of liver disease and <span class="disease" id="22022477-4-110-113">HCC</span> in <span class="gene" id="22022477-4-117-121">Mdr2</span>(-/-) mice, we generated <span class="gene" id="22022477-4-146-150">Mdr2</span>-deficient animals lacking IKK2 specifically in hepatocytes using the Cre-loxP system.