HCM
Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric septal hypertrophy and is often caused by mutations in MYBPC3 gene encoding cardiac myosin-binding protein C. In contrast to humans, who are already affected at the heterozygous state, mouse models develop the phenotype mainly at the homozygous state.
<span class="disease" id="22076249-1-0-27">Hypertrophic cardiomyopathy</span> (<span class="disease" id="22076249-1-29-32">HCM</span>) is characterized by asymmetric septal hypertrophy and is often caused by mutations in <span class="gene" id="22076249-1-120-126">MYBPC3</span> gene encoding cardiac myosin-binding protein C. In contrast to humans, who are already affected at the heterozygous state, mouse models develop the phenotype mainly at the homozygous state.