emphysema
Here we report that Itgb6-null mice develop age-related emphysema that is completely abrogated either by transgenic expression of versions of the beta6 integrin subunit that support TGF-beta activation, or by the loss of Mmp12.
Here we report that <span class="gene" id="12634787-4-20-25">Itgb6</span>-null mice develop age-related <span class="disease" id="12634787-4-56-65">emphysema</span> that is completely abrogated either by transgenic expression of versions of the beta6 integrin subunit that support TGF-beta activation, or by the loss of Mmp12.