Hyperalgesia
Hyperalgesia induced by prostaglandin E2 remained unaffected by FR173657.5.Blood pressure reflexes following i.p. instillation of bradykinin in anaesthetized rats were inhibited by FR173657 s.c. with an ID50 of 1.1 micromol kg(-1), while the peptidic B2 antagonist icatibant (Hoe-140; D-Arg0-[Hyp3, Thi5, D-Tic7, Oic8]-bradykinin) caused inhibition at significantly lower doses (ID50 8.5 nmol kg(-1) P < 0.001).Responses to hydrochloric acid i.p. remained unaffected by FR173657.6.
<span class="disease" id="9720808-7-0-12">Hyperalgesia</span> induced by prostaglandin E2 remained unaffected by FR173657.5.Blood pressure reflexes following i.p. instillation of <span class="gene" id="9720808-7-130-140">bradykinin</span> in anaesthetized rats were inhibited by FR173657 s.c. with an ID50 of 1.1 micromol kg(-1), while the peptidic B2 antagonist icatibant (Hoe-140; D-Arg0-[Hyp3, Thi5, D-Tic7, Oic8]-<span class="gene" id="9720808-7-319-329">bradykinin</span>) caused inhibition at significantly lower doses (ID50 8.5 nmol kg(-1) P &lt; 0.001).Responses to hydrochloric acid i.p. remained unaffected by FR173657.6.