hepatocellular carcinomas
We have therefore generated 'knock-in' mouse embryonic stem (ES) cells to investigate the effects of expressing a commonly found hot-spot p53 mutant, R246S -- the mouse equivalent of human R249S, which is associated with hepatocellular carcinomas.
We have therefore generated 'knock-in' mouse embryonic stem (ES) cells to investigate the effects of expressing a commonly found hot-spot <span class="gene" id="18477611-4-138-141">p53</span> mutant, R246S -- the mouse equivalent of human R249S, which is associated with <span class="disease" id="18477611-4-221-246">hepatocellular carcinomas</span>.