ISH
Finally, and possibly providing insight into the pathophysiology of these diseases, analysis of fibroblasts derived from patients with JHF or ISH suggests that CMG2 mutations abrogate normal cell interactions with the extracellular matrix.
Finally, and possibly providing insight into the pathophysiology of these diseases, analysis of fibroblasts derived from patients with <span class="disease" id="12973667-8-135-138">JHF</span> or <span class="disease" id="12973667-8-142-145">ISH</span> suggests that <span class="gene" id="12973667-8-160-164">CMG2</span> mutations abrogate normal cell interactions with the extracellular matrix.