alcoholic liver disease
Osteopontin (OPN) up-regulation is known to mediate hepatic inflammation in a rodent model of alcoholic liver disease (ALD) and alcohol ingestion is reported to inhibit hepatic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activity leading to hepatic steatosis and inflammation.
<span class="gene" id="18703563-1-0-11">Osteopontin</span> (<span class="gene" id="18703563-1-13-16">OPN</span>) up-regulation is known to mediate hepatic inflammation in a rodent model of <span class="disease" id="18703563-1-94-117">alcoholic liver disease</span> (ALD) and alcohol ingestion is reported to inhibit hepatic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activity leading to hepatic steatosis and inflammation.