Brugada syndrome
Loss-of-function mutations in SCN5A, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and Brugada syndrome, which both exhibit variable phenotypic penetrance of conduction defects.
Loss-of-function mutations in <span class="gene" id="20174578-1-30-35">SCN5A</span>, the gene encoding Na(v)1.5 Na+ channel, are associated with inherited cardiac conduction defects and <span class="disease" id="20174578-1-138-154">Brugada syndrome</span>, which both exhibit variable phenotypic penetrance of conduction defects.