tumor necrosis factor-a
In the present study, our results showed that treatment with montelukast could protect DA neurons against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity and its administration significantly attenuated the production of neurotoxic cytokines such as tumor necrosis factor-a (TNFa) and interleukin-1b (IL-1b) from activated microglia in the substantia nigra (SN) and striatum following 6-OHDA treatment.