medulloblastoma
To study the role of Ptc1 in cerebellar tumor development and to create a preclinical therapeutic platform, we have generated a conditional Ptc1 haploinsufficiency model of medulloblastoma by inactivating Ptc1 in Pax7-expressing cells of the cerebellum.
To study the role of <span class="gene" id="19213072-3-21-25">Ptc1</span> in cerebellar tumor development and to create a preclinical therapeutic platform, we have generated a conditional <span class="gene" id="19213072-3-140-144">Ptc1</span> haploinsufficiency model of <span class="disease" id="19213072-3-173-188">medulloblastoma</span> by inactivating <span class="gene" id="19213072-3-205-209">Ptc1</span> in Pax7-expressing cells of the cerebellum.