T-ALL
We and others have shown that Notch1 directly regulates c-Myc, a known regulator of quiescence in stem and progenitor populations, leading us to examine whether c-Myc inhibition results in efficient targeting of T-ALL-initiating cells.
We and others have shown that <span class="gene" id="24394663-3-30-36">Notch1</span> directly regulates c-Myc, a known regulator of quiescence in stem and progenitor populations, leading us to examine whether c-Myc inhibition results in efficient targeting of <span class="disease" id="24394663-3-212-217">T-ALL</span>-initiating cells.