leukemia
Our results clarify the relationship between Noonan syndrome and leukemia and show that a single Ptpn11 gain-of-function mutation evokes all major features of Noonan syndrome by acting on multiple developmental lineages in a gene dosage-dependent and pathway-selective manner.
Our results clarify the relationship between Noonan syndrome and <span class="disease" id="15273746-8-65-73">leukemia</span> and show that a single <span class="gene" id="15273746-8-97-103">Ptpn11</span> gain-of-function mutation evokes all major features of Noonan syndrome by acting on multiple developmental lineages in a gene dosage-dependent and pathway-selective manner.