breast tumors
We conducted a comprehensive genetic analysis of two independent cohorts of metastatic ER-positive breast tumors and identified mutations in ESR1 affecting the ligand-binding domain (LBD) in 14 of 80 cases.
We conducted a comprehensive genetic analysis of two independent cohorts of metastatic <span class="gene" id="24185512-3-87-89">ER</span>-positive <span class="disease" id="24185512-3-99-112">breast tumors</span> and identified mutations in <span class="gene" id="24185512-3-141-145">ESR1</span> affecting the ligand-binding domain (LBD) in 14 of 80 cases.