Wilson disease
The Long-Evans cinnamon (LEC) rat, an authentic model for Wilson disease, is characterized by a mutation in the Atp7b gene leading to a defective copper excretion and, as a consequence, to an accumulation of the metal in the liver and copper-associated hepatotoxicity.
The Long-Evans cinnamon (LEC) rat, an authentic model for <span class="disease" id="14574444-1-58-72">Wilson disease</span>, is characterized by a mutation in the <span class="gene" id="14574444-1-112-117">Atp7b</span> gene leading to a defective copper excretion and, as a consequence, to an accumulation of the metal in the liver and copper-associated hepatotoxicity.