alcohol dependence
The hypothesized mechanism underlying the associations of the ADH1B and ALDH2 polymorphisms with alcohol dependence is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism.
The hypothesized mechanism underlying the associations of the <span class="gene" id="16404797-5-62-67">ADH1B</span> and ALDH2 polymorphisms with <span class="disease" id="16404797-5-97-115">alcohol dependence</span> is that the isoenzymes encoded by these alleles lead to an accumulation of acetaldehyde during alcohol metabolism.