type 2 diabetes mellitus
We document here that leptin replacement therapy in leptin-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of type 2 diabetes mellitus and hypogonadism, and beneficial effects on ingestive and noningestive behavior.
We document here that <span class="gene" id="15070752-8-22-28">leptin</span> replacement therapy in <span class="gene" id="15070752-8-52-58">leptin</span>-deficient adults with established morbid obesity results in profound weight loss, increased physical activity, changes in endocrine function and metabolism, including resolution of <span class="disease" id="15070752-8-240-264">type 2 diabetes mellitus</span> and hypogonadism, and beneficial effects on ingestive and noningestive behavior.