myositis
Because IL-1alpha and IL-1beta, and the anti-inflammatory competitive inhibitor, IL-1 receptor antagonist (IL-1Ra), have been implicated in the pathogenesis of myositis, we assessed the role of variable number tandem repeat (VNTR) polymorphisms of the IL-1Ra gene (IL-1RN) in the aetiology of JIIM: IL-1RN VNTR polymorphisms were performed on 250 JIIM patients and 471 race-matched controls and were correlated with clinical characteristics.
Because IL-1alpha and IL-1beta, and the anti-inflammatory competitive inhibitor, IL-1 receptor antagonist (<span class="gene" id="10886238-2-107-113">IL-1Ra</span>), have been implicated in the pathogenesis of <span class="disease" id="10886238-2-160-168">myositis</span>, we assessed the role of variable number tandem repeat (VNTR) polymorphisms of the <span class="gene" id="10886238-2-252-258">IL-1Ra</span> gene (<span class="gene" id="10886238-2-265-271">IL-1RN</span>) in the aetiology of JIIM: <span class="gene" id="10886238-2-299-305">IL-1RN</span> VNTR polymorphisms were performed on 250 JIIM patients and 471 race-matched controls and were correlated with clinical characteristics.