metastasized
In a nude mouse model of bone metastasis, the MDA-MB-231 human breast cancer cells showed no COX-2 expression at orthotopic sites, whereas these cells, when metastasized to bone, intensely expressed COX-2, suggesting that the bone microenvironment induced COX-2 expression.
In a nude mouse model of bone metastasis, the MDA-MB-231 human breast cancer cells showed no <span class="gene" id="16489006-5-93-98">COX-2</span> expression at orthotopic sites, whereas these cells, when <span class="disease" id="16489006-5-157-169">metastasized</span> to bone, intensely expressed <span class="gene" id="16489006-5-199-204">COX-2</span>, suggesting that the bone microenvironment induced <span class="gene" id="16489006-5-256-261">COX-2</span> expression.