atopic dermatitis
On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with atopic dermatitis and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 × 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 × 10(-20)), OR10A3-NLRP10 (P = 1.54 × 10(-22)), GLB1 (P = 2.77 × 10(-16)), CCDC80 (P = 1.56 × 10(-19)), CARD11 (P = 7.83 × 10(-9)), ZNF365 (P = 5.85 × 10(-20)) and CYP24A1-PFDN4 (P = 1.65 × 10(-8)).
On the basis of data from a genome-wide association study (GWAS) and a validation study comprising a total of 3,328 subjects with <span class="disease" id="23042114-2-130-147">atopic dermatitis</span> and 14,992 controls in the Japanese population, we report here 8 new susceptibility loci: IL1RL1-IL18R1-IL18RAP (P(combined) = 8.36 &times; 10(-18)), the major histocompatibility complex (MHC) region (P = 8.38 &times; 10(-20)), OR10A3-NLRP10 (P = 1.54 &times; 10(-22)), GLB1 (P = 2.77 &times; 10(-16)), CCDC80 (P = 1.56 &times; 10(-19)), CARD11 (P = 7.83 &times; 10(-9)), <span class="gene" id="23042114-2-484-490">ZNF365</span> (P = 5.85 &times; 10(-20)) and CYP24A1-PFDN4 (P = 1.65 &times; 10(-8)).