MOTA
Recessive mutations in the FRAS1-related extracellular matrix 1 (FREM1) gene have been shown to cause bifid nose with or without anorectal and renal anomalies (BNAR) syndrome and Manitoba oculotrichoanal (MOTA) syndrome, but have not been previously implicated in the development of CDH.
Recessive mutations in the <span class="gene" id="23221805-2-27-63">FRAS1-related extracellular matrix 1</span> (<span class="gene" id="23221805-2-65-70">FREM1</span>) gene have been shown to cause bifid nose with or without anorectal and renal anomalies (BNAR) syndrome and Manitoba oculotrichoanal (<span class="disease" id="23221805-2-205-209">MOTA</span>) syndrome, but have not been previously implicated in the development of CDH.