keratoconus
We further showed that 2 CCT-associated loci, FOXO1 and FNDC3B, conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 × 10(-10), and rs4894535 in FNDC3B had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 × 10(-9)).
We further showed that 2 CCT-associated loci, FOXO1 and <span class="gene" id="23291589-3-56-62">FNDC3B</span>, conferred relatively large risks for <span class="disease" id="23291589-3-101-112">keratoconus</span> in 2 cohorts with 874 cases and 6,085 controls (rs2721051 near FOXO1 had odds ratio (OR) = 1.62, 95% confidence interval (CI) = 1.4-1.88, P = 2.7 &times; 10(-10), and rs4894535 in <span class="gene" id="23291589-3-287-293">FNDC3B</span> had OR = 1.47, 95% CI = 1.29-1.68, P = 4.9 &times; 10(-9)).