ankylosing spondylitis
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with ankylosing spondylitis (P < 5 × 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, TBKBP1, ANTXR2 and CARD9 that show strong association across all our datasets (P < 5 × 10(-6) overall, with support in each of the three datasets studied).
Here we report the identification of three variants in the RUNX3, LTBR-TNFRSF1A and IL12B regions convincingly associated with <span class="disease" id="21743469-2-127-149">ankylosing spondylitis</span> (P &lt; 5 &times; 10(-8) in the combined discovery and replication datasets) and a further four loci at PTGER4, <span class="gene" id="21743469-2-253-259">TBKBP1</span>, ANTXR2 and CARD9 that show strong association across all our datasets (P &lt; 5 &times; 10(-6) overall, with support in each of the three datasets studied).