pain
We also verified that L-NAME (50 mg/kg i.c.) reduced the BK-, but not the CAP- and/or RCM-induced pain responses which suggests that an L-arginine-derived NO or related compound is involved in BK activation of perivascular nociceptors.Indeed, we found that i.c. injection of 20 mg of S-nitrosocysteine, a putative EDRF, caused BK-like responses.
We also verified that L-NAME (50 mg/kg i.c.) reduced the <span class="gene" id="1281941-5-57-59">BK</span>-, but not the CAP- and/or RCM-induced <span class="disease" id="1281941-5-98-102">pain</span> responses which suggests that an L-arginine-derived NO or related compound is involved in <span class="gene" id="1281941-5-193-195">BK</span> activation of perivascular nociceptors.Indeed, we found that i.c. injection of 20 mg of S-nitrosocysteine, a putative EDRF, caused <span class="gene" id="1281941-5-327-329">BK</span>-like responses.