HCC
The overall commonality of expression between AOX-/- and ciprofibrate-induced liver tumors but not with DENA-induced tumors strongly implicates the activation of PPARalpha and PPARalpha-regulated genes in liver, including those participating in lipid catabolism, as key factors in the development of HCC in AOX-/- and in ciprofibrate-treated mice.
The overall commonality of expression between <span class="gene" id="12771043-5-46-49">AOX</span>-/- and ciprofibrate-induced liver tumors but not with DENA-induced tumors strongly implicates the activation of PPARalpha and PPARalpha-regulated genes in liver, including those participating in lipid catabolism, as key factors in the development of <span class="disease" id="12771043-5-300-303">HCC</span> in <span class="gene" id="12771043-5-307-310">AOX</span>-/- and in ciprofibrate-treated mice.