MI
Real time reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that the expression of mineralocorticoid receptor (MR) mRNA and that of 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) mRNA, which is known to confer aldosterone selectivity on MR, were upregulated in the untreated MI group, and that spironolactone significantly suppressed the expression of these genes.
Real time reverse transcription-polymerase chain reaction (RT-PCR) analysis showed that the expression of <span class="gene" id="17587755-9-106-132">mineralocorticoid receptor</span> (<span class="gene" id="17587755-9-134-136">MR</span>) mRNA and that of 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) mRNA, which is known to confer aldosterone selectivity on <span class="gene" id="17587755-9-265-267">MR</span>, were upregulated in the untreated <span class="disease" id="17587755-9-303-305">MI</span> group, and that spironolactone significantly suppressed the expression of these genes.