hyperalgesia
In wild-type mice, activation of PKRs by the PKR agonist Bv8 caused hyperalgesia and sensitized to the actions of capsaicin. pkr1-null mice exhibited impaired responses to Bv8 but showed normal hyperalgesic responses to bradykinin and PGE2 (prostaglandin E2).
In wild-type mice, activation of PKRs by the PKR agonist Bv8 caused <span class="disease" id="16793879-5-68-80">hyperalgesia</span> and sensitized to the actions of capsaicin. <span class="gene" id="16793879-5-125-129">pkr1</span>-null mice exhibited impaired responses to Bv8 but showed normal hyperalgesic responses to bradykinin and PGE2 (prostaglandin E2).