APL
These findings reveal a novel ATRA signaling on APL cell differentiation, in which ATRA coordinates G1 arrest and transition into differentiation by inducing MAT1 degradation and PML/RARalpha hypophosphorylation through disrupting PML/RARalpha binding and phosphorylation by CAK.
These findings reveal a novel ATRA signaling on <span class="disease" id="16935935-9-48-51">APL</span> cell differentiation, in which ATRA coordinates G1 arrest and transition into differentiation by inducing MAT1 degradation and <span class="gene" id="16935935-9-179-182">PML</span>/RARalpha hypophosphorylation through disrupting <span class="gene" id="16935935-9-231-234">PML</span>/RARalpha binding and phosphorylation by CAK.