Noonan syndrome
Increased RAS signaling owing to PTPN11, SOS1 and KRAS mutations causes approximately 60% of Noonan syndrome cases, and PTPN11 mutations cause 90% of LEOPARD syndrome cases.
Increased RAS signaling owing to PTPN11, SOS1 and <span class="gene" id="17603483-2-50-54">KRAS</span> mutations causes approximately 60% of <span class="disease" id="17603483-2-93-108">Noonan syndrome</span> cases, and PTPN11 mutations cause 90% of LEOPARD syndrome cases.