APL
Induction of apoptosis was seen also in the PML-RARalpha-expressing APL cell line NB4, and in several other atRA-sensitive leukemia cell lines, demonstrating that this effect is limited neither to the monocyte lineage nor to the rare NPM-RARalpha fusion variant.
Induction of apoptosis was seen also in the PML-RARalpha-expressing <span class="disease" id="14508522-7-68-71">APL</span> cell line NB4, and in several other atRA-sensitive leukemia cell lines, demonstrating that this effect is limited neither to the monocyte lineage nor to the rare <span class="gene" id="14508522-7-234-237">NPM</span>-RARalpha fusion variant.