pain
Furthermore we studied effects of histamine H1 and H2 receptor antagonists on orexin A-produced antinociception in C57BL/6 mice.The antinociceptive effects of i.c.v. orexin A were greater in histamine H1 receptor or H2 receptor knockout mice than in the wild-type mice in all four assays of pain.
Furthermore we studied effects of histamine H1 and H2 receptor antagonists on <span class="gene" id="16202530-6-78-84">orexin</span> A-produced antinociception in C57BL/6 mice.The antinociceptive effects of i.c.v. <span class="gene" id="16202530-6-166-172">orexin</span> A were greater in histamine H1 receptor or H2 receptor knockout mice than in the wild-type mice in all four assays of <span class="disease" id="16202530-6-291-295">pain</span>.