HDR-syndrome
Based on observations that mutations of GATA-3 are responsible for the HDR-syndrome (hypoparathyroidism, deafness, renal defects) and that GATA-transcription factors have an important role to play in inner ear development, we hypothesized that these transcription factors may be involved in regulatory changes of prestin transcription.
Based on observations that mutations of <span class="gene" id="20006695-1-40-46">GATA-3</span> are responsible for the <span class="disease" id="20006695-1-71-83">HDR-syndrome</span> (hypoparathyroidism, deafness, renal defects) and that GATA-transcription factors have an important role to play in inner ear development, we hypothesized that these transcription factors may be involved in regulatory changes of prestin transcription.