MFS
Mice that harbor both a mutant Marfan syndrome (MFS) allele (Fbn1(C1039G/+)) and Tgfb2 haploinsufficiency show increased TGF-? signaling and phenotypic worsening in association with normalization of TGF-?2 expression and high expression of TGF-?1.
Mice that harbor both a mutant <span class="disease" id="22772368-4-31-46">Marfan syndrome</span> (<span class="disease" id="22772368-4-48-51">MFS</span>) allele (<span class="gene" id="22772368-4-61-65">Fbn1</span>(C1039G/+)) and Tgfb2 haploinsufficiency show increased TGF-&beta; signaling and phenotypic worsening in association with normalization of TGF-&beta;2 expression and high expression of TGF-&beta;1.