Hfe
The iron burden in Bmp6 mutant mice is significantly greater than that in mice deficient in the gene associated with classical hemochromatosis (Hfe), suggesting that mutations in BMP6 might cause iron overload in humans with severe juvenile hemochromatosis for which the genetic basis has not yet been characterized.
The iron burden in <span class="gene" id="19252488-8-19-23">Bmp6</span> mutant mice is significantly greater than that in mice deficient in the gene associated with classical <span class="disease" id="19252488-8-127-142">hemochromatosis</span> (<span class="disease" id="19252488-8-144-147">Hfe</span>), suggesting that mutations in <span class="gene" id="19252488-8-179-183">BMP6</span> might cause iron overload in humans with severe juvenile hemochromatosis for which the genetic basis has not yet been characterized.