N'ozuzu, ion hydride bụ otu na-ahapụ ogbenye ma na-eme naanị na ole na ole heterocyclic mmeghachi omume. Ha na-agụnye mmeghachi omume Chichibabin, nke na-enye pyridine derivatives aminated na 2-position. N'ebe a, sodium amide na-eji dị ka nucleophile na-enye 2-opyrine. The ion hydride tọhapụrụ na mmeghachi omume a na-ejikọta ya na proton nke amino benzene, na-ahapụ otu proton nke benzene, na-aghọ otu ìgwè na-ahapụ.
nucleophile na-enye 2-aminopyridine