N'ọnwa Nọvemba afọ 2004, Clinton kwupụtara na ọ ga-achọ ọkwa Senate nke abụọ. Clinton meriri nhọpụta ndị Democrats n'ụzọ dị mfe n'ihi mmegide sitere n'aka onye na-emegide agha agha Jonathan Tasini. Onye isi mmalite nke ndị Republican, Westchester County District Attorney Jeanine Pirro, kwụsịrị asọmpi ahụ mgbe ọnwa ole na ole nke mkpọsa ọjọọ. Onye na-emegide Clinton na ntuli aka nke Republican bụ John Spencer, onye bụbu Mayor nke Yonkers. Clinton meriri ntuli aka na November 7, 2006, na pasent 67 nke votu na pasent 31 nke Spencer, na-eburu ihe niile ma anọ nke New York si iri isii na abụọ.
Afọ 2008