N'afọ 1920, Michael Heidelberger na Oswald Avery chọpụtara na antibodies nwere ike ịdọrọ site antibodies wee gaa n'ihu na-egosi na antibodies na-mere nke protein. Ndị a biochemical Njirimara nke antigen-antibody-ejikọta mmekọrịta e nyochara n'ụzọ zuru ezu ná ngwụsị afọ ndị 1930 site John Marrack. The ọzọ isi ọganihu bụ na 1940, mgbe Linus Pauling kwadoro mkpọchi-na-mkpịsị ugodi tiori chọrọ site Ehrlich site n'igosi na mmekọrịta n'etiti antibodies na antibodies na-adabere na ha udi karịa ha chemical mejupụtara. Na 1948, Astrid Fagreaus chọpụtara na B mkpụrụ ndụ, n'ụdị plasma mkpụrụ ndụ, ndị na-ahụ maka amịpụta antibodies.
na- akọwapụta ihe ndị mejupụtara protein ndị ahụ na- alụso nje ọgụ.