"Toxic" meriri Spears mbụ ya na naanị Grammy Award na 2005 ememe na udi nke Best Dance Recording. "Toxic" nwetara ihe ịga nke ọma n'ụwa nile, na-eru n'elu ise na mba 15, mgbe na-eduga chaatị dị na Australia, Canada, Hungary, Ireland, Norway na United Kingdom. Na United States, ọ ghọrọ nke anọ ya n'elu iri, na-eru na nọmba 9. The esonyere music video maka song na-eduzi Joseph Kahn na atụmatụ zoro aka na Blade Runner, The Seven Year Itch na fim nke John Woo. Ọ na-egosiputa Spears dị ka a nzuzo gị n'ụlọnga na-achọ a vial nke green mmiri mmiri. Mgbe ọ na-ezu ohi ya, ọ na-abanye a ulo na-ekwesịghị ntụkwasị obi enyi ya nwoke kwagara na video na-agụnye ihe nkiri nke Janet Jackson na-egbu egbu egbu na-egbu egbu na-egbu egbu na-egbu egbu na-egbu egbu.
enyi ya nwoke na-anaghị ekwesị ntụkwasị obi