na mbụ, naive B mkpụrụ ndụ na-egosipụta naanị cell-elu IgM na IgD na yiri antigen nkekọ mpaghara. Onye ọ bụla isotype na-emegharị maka a dị iche iche ọrụ; Ya mere, mgbe ebighị, ihe antibody na IgG, IgA, ma ọ bụ IgE effector ọrụ nwere ike a chọrọ iji n'ụzọ dị irè kpochapụ ihe antigen. Class switching na-enye ohere dị iche iche nwa mkpụrụ ndụ site na otu B cell na-emepụta dị iche iche antibodies. Naanị mpaghara nke antibody na-agbanwe agbanwe n'oge ọ bụla na-agbanwe agbanwe mpaghara, na ya mere ndị na-agbanwe agbanwe na-arụ ọrụ, na-adabere na otu enzyme nke na-emepụta ihe na-agbanwe agbanwe site na mpaghara mgbochi mgbochi mgbochi nke a na-akpọ DNA. Nke a na-eme site na otu enzyme na-agbanwe agbanwe nke na-emepụta ihe na-agbanwe agbanwe site na mpaghara mgbochi mgbochi nke na-agbanwe agbanwe. Nke a na-adabere na usoro nke na-agbanwe agbanwe site na mpaghara mgbochi mgbochi nke na-agbanwe agbanwe nke a na-akpọ
ihe ndị e chebere na nucleotide