Ọkà mmụta ahụike bụ Johannes Müller (1801<unk>1858) kọwara fibrin, ihe dị na thrombus. Ihe na-edozi ahụ ya, fibrinogen, bụ nke Rudolf Virchow (1821<unk>1902), na nke dịpụrụ adịpụ site na kemịkal site na Prosper Sylvain Denis (1799<unk>1863). Alexander Schmidt tụrụ aro na ntụgharị site na fibrinogen na fibrin bụ nsonaazụ nke usoro enzymatic, wee kpọọ enzyme hypothetical "thrombin" na onye bu ya ụzọ "prothrombin". Arthus chọpụtara na 1890 na calcium dị mkpa na coagulation. E gosipụtara Platelets na 1865, Giulio Bizzo chọpụtara ọrụ ha na 1882.
1801<unk>1858