Mezue ahịrịokwu na-esonụ: Cavani gbara goolu n'asọmpi mbụ ya na Uruguay megide Colombia na 6 Febụwarị 2008, kemgbe ahụ ọ nwetala egwuregwu 123 ma gbaa goolu mba ụwa 53, naanị n'azụ onye na-akụ aka Luis Suárez n'etiti mba ụwa Uruguay. O sonyere na asọmpi mba ụwa itoolu: FIFA World Cup na 2010, 2014 na 2018, Copa América na 2011, 2015,
2016, 2019 na 2021, na FIFA Confederations Cup na 2013. O nyere otu goolu na 2010 World Cup iji nyere Uruguay aka n'ọnọdụ nke anọ na asọmpi ahụ, na 2011 bụ akụkụ nke ndị otu Uruguay nke meriri aha iri na ise nke Copa América. O mechiri dị ka CONMEBOL 2018 World Cup qualification top scorer na ihe mgbaru ọsọ iri.