Mezue ahịrịokwu na-esonụ: Ka ọ na-erule afọ 1937, Moorehead sonyeere Orson Welles' Mercury Players, dịka otu n'ime ndị isi ya na-eme ihe nkiri ya na Joseph Cotten. (N'ihe ngosi ya na "The Dick Cavett Show" na February 19, 1973, ọ kpughere na, na 1922, ọ zutere Welles (afọ iri na ise na-eto eto) mgbe ọ dị naanị afọ asaa na Waldorf-Astoria Hotel na New York City.) Ọ rụrụ na redio ya "The Mercury Theatre on the Air", ma nwee ọrụ na-aga n'ihu na Welles na usoro "The Shadow" dị ka Margo Lane. Na 1939, Welles kwagara Mercury Theatre na Hollywood, ebe ọ malitere ịrụ ọrụ maka RKO Pictures. Ọtụtụ n'ime ndị na-eme ihe nkiri redio ya sonyeere ya, Moorehead mekwara ihe nkiri mbụ ya dị ka nne nke agwa ya, Charles Foster Kane, na "Citizen Kane" (1941), nke ọtụtụ ndị na-akatọ ihe nkiri na-ewere dị ka otu n'ime ihe nkiri kachasị mma e mepụtara. E gosipụtara Moorehead na fim nke abụọ Welles, "The Magnificent Ambersons" (1942), wee nata New York Film Critics Award na
Nhoputa Academy Award maka arụmọrụ ya. Ọ pụtakwara na "Journey Into Fear" (1943), ihe nkiri Mercury.