Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Oge: Na mbido afọ 1980s, Cruise nwere mmekọrịta ya na ụmụ nwanyị ndị okenye, gụnyere Rebecca De Mornay, afọ atọ ya; Patti Scialfa, afọ itoolu ya; na Cher, afọ 16 ya. Cruise lụrụ onye na-eme ihe nkiri Mimi Rogers na Mee 9, 1987. Ha gbara alụkwaghịm na February 4, 1990. Rogers mere ka Cruise mata Chọọchị Scientology. O zutere nwunye ya nke abụọ, onye na-eme ihe nkiri Nicole Kidman, na ntinye nke ihe nkiri ha Days of Thunder (1990). Di na nwunye ahụ lụrụ na December 24, 1990. Cruise na Kidman kuchiri ụmụ abụọ, Isabella Jane (amụrụ 1992) na Connor Antony (amụrụ 1995). Na February 2001, Cruise gbara akwụkwọ ịgba alụkwaghịm site na Kidman mgbe ọ dị ime n'amaghị ama. Ọ tụụrụ ime. N'afọ 2007, Kidman mere ka a mata nke ọma banyere asịrị nke ite ime n'oge alụmdi na nwunye ya na Cruise, na-ekwu na N'ajụjụ ọnụ, "A kọọrọ ya n'ụzọ na-ezighi ezi, " ma kọwaa na ọ nwere n'ezie ime ime. Tupu alụmdi na nwunye ọzọ nke Kidman na Keith Urban, o kwuru banyere etu o si hụ Cruise n'anya, na-ekwu na 2006: "Ọ bụ nnukwu; ka dị. Nye m, ọ bụ nanị Tom, ma nye onye ọ bụla ọzọ, ọ bụ nnukwu mmadụ. Ma, o meere m ihe ọma. Ahụrụ m ya n'anya. M ka hụrụ ya n'anya".  Ajụjụ: Olee mgbe Tom Cruise gbara akwụkwọ ịgba Nicole Kidman alụkwaghịm?
February 2001