Mezue ahịrịokwu na-esonụ: N'afọ 2011, ọrụ Grilli bidoro dịka onye na-agbatị bọọlụ na Pittsburgh Pirates. N'afọ ahụ, o nwere 2.48 nkezi ọsọ ọsọ (ERA) na 10.2 strikeouts kwa innings itoolu (K/9) na 32 innings pitched (IP), ma nwekwuo ọganihu na 2012, mgbe ọnụego ya na-arịgo na 13.8. Na 2013, Grilli mere nke mbụ ya
Ọ bụ onye otu All-Star ma bụrụ onye na-emechi Pittsburgh mgbe ọ dị afọ 36. Site na 2011 ruo 2014, o chịkọtara 3.09 ERA na 11.9 K/9, 3.3 BB/9 na 34.2 pasent nke ala-bọl na IP.