N'afọ 1543, Andreas Vesalius bidoro usoro ọgwụgwọ ọdịda anyanwụ nke oge a site na akwụkwọ ya nke anụ ahụ mmadụ De humani corporis fabrica, nke dabere na nyocha nke ozu. Vesalius bụ onye mbụ n'ime usoro nke ndị na-ahụ maka ahụ mmadụ nke ji nwayọọ nwayọọ dochie anya agụmakwụkwọ na ahụmịhe na ahụike, na-adabere na ahụmịhe mbụ kama ịbụ ikike na arụmụka nkịtị. Site na herbalism, ọgwụ bụkwa isi iyi nke mmeghari ohuru nke ahụmịhe na ọmụmụ nke osisi. Otto Brunfels, Hieronymus Bock na Leonhart Fuchs dere ọtụtụ ihe banyere osisi, mmalite nke usoro okike nke dabeere na okike na ndụ osisi.
osisi ọhịa