A na-achọpụta ọrịa Alzheimer dị ka ọrịa protein na-adịghị mma (proteopathy), nke a na-akpata site na nchịkọta nke protein amyloid beta na protein tau na ụbụrụ. Ejiri obere peptides, 39 <unk> 43 amino acids n'ogologo, nke a na-akpọ amyloid beta (Aβ). Aβ bụ akụkụ nke protein amyloid precursor protein (APP) buru ibu. APP bụ protein transmembrane nke na-abanye n'ime akpụkpọ ahụ nke neuron. APP dị oke mkpa maka uto neuron, nlanarị, na mmezi post-injury. Na ọrịa Alzheimer, gamma secretase na beta secretase na-arụkọ ọrụ ọnụ na usoro protein nke APP na-ekewa n'ime obere iberibe. Otu n'ime iberibe ndị a na-enye ohere ka mkpokọta nke amyloid beta clumps, nke na-eme ka mkpokọta nke neuronal na-akpọ amyloid beta (Aβ). Aβ bụ akụkụ sitere na protein amyloid precursor protein (APP) buru ibu.
protein jikọtara na microtubule