N'ihe dị ka n'etiti afọ 1980, Cruise nwere mmekọrịta ya na ụmụ nwanyị ndị okenye, gụnyere Rebecca De Mornay, afọ atọ okenye ya; Patti Scialfa, afọ itoolu okenye ya; na Cher, afọ 16 okenye ya. Cruise lụrụ omee Mimi Rogers na Mee 9, 1987. Ha gbara alụkwaghịm na February 4, 1990. Rogers mere ka Cruise mata Chọọchị Scientology. O zutere nwunye ya nke abụọ, omee Nicole Kidman, na set nke ihe nkiri ha Days of Thunder (1990). Di na nwunye ahụ lụrụ na Disemba 24, 1990. Cruise na Kidman kuchiri ụmụ abụọ, Isabella Jane (amụrụ 1992) na Connor Antony (amụrụ 1995). Na February 2001, Cruise gbara akwụkwọ maka ịgba alụkwaghịm site n'aka Kidman mgbe ọ dị ime. Ime ahụ kwụsịrị na ime ọpụpụ. N'afọ 2007, Kidman mere ka a mata nke ọma na ọ bụ ime ọpụpụ n'oge alụmdi na nwunye ya na Cruise, na-ekwu na N'ajụjụ ọnụ, "Ọ bụ akụkọ na-ezighi ezi", na-akọwa na ọ nwere ime ime Urban.
February 2001