Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Ihe na-eme: A chọpụtawo ọrịa Alzheimer dị ka ọrịa nke na-eme ka protein na-agbakọ agbakọ (proteopathy), nke na-akpata mkpụkọ nke protein amyloid beta na protein tau na ụbụrụ. A na-eji obere peptides, 39<unk>43 amino acids n'ogologo, nke a na-akpọ amyloid beta (Aβ) eme ihe. Aβ bụ akụkụ nke nnukwu protein amyloid precursor (APP). APP bụ protein na-esi n'akpụkpọ ahụ banye n'akpụkpọ ahụ nke mkpụrụ ndụ akwara. APP dị oké mkpa maka uto nke mkpụrụ ndụ akwara, nlanarị, na mmezi mgbe mmerụ ahụ gasịrị. N'ọrịa Alzheimer, gamma secretase na beta secretase na-arụkọ ọrụ ọnụ n'ime usoro proteolytic nke na-eme ka APP kewaa n'ime obere iberibe. Otu n'ime iberibe ndị a na-ebute fibrils nke amyloid beta, nke na-emezi ụyọkọ nke na-etinye n'èzí neurons n'ime ihe ndị siri ike a maara dị ka plaques senile. A na-ewerekwa AD dị ka tauopathy n'ihi mkpokọta na-adịghị mma nke protein tau. N'ime mkpụrụ ndụ akwara nke ọ bụla, e nwere ihe a na-akpọ cytoskeleton, nke bụ́ ihe na-akwado ya n'ime ahụ́, nke e ji ihe ndị a na-akpọ microtubules mee. Microtubules ndị a na-arụ ọrụ dị ka okporo ụzọ, na-eduzi ihe ndị na-edozi ahụ na ụmụ irighiri ihe ndị dị n'ime mkpụrụ ndụ gaa ná nsọtụ nke axon ma laghachi azụ. Protein a na-akpọ tau na-eme ka microtubules kwụsie ike mgbe a na-eme phosphorylated, ya mere a na-akpọ ya protein metụtara microtubule. Na AD, tau na-enwe mgbanwe kemịkal, na-aghọ hyperphosphorylated; ọ na-amalitezie ijikọta ya na eriri ndị ọzọ, na-emepụta ụdọ ụbụrụ na-eme ka usoro njem nke neuron mebie. Pathogenic tau nwekwara ike ịkpata ọnwụ neuronal site na transposable element dysregulation.  Ajụjụ: olee aha ọzọ a na-akpọ protein nke a na-akpọ phosphorylated?
protein jikọtara na microtubule