Mgbe ọ dị afọ iri na isii, Barrymore wepụtara akwụkwọ akụkọ ndụ ya, Little Girl Lost, na 1991. Ọ gara n'ihu na-apụta na ọtụtụ ihe nkiri na-aga nke ọma n'ime afọ iri ahụ, gụnyere Poison Ivy (1992), Boys on the Side (1995), Mad Love (1995), Scream (1996), Ever After (1998) na The Wedding Singer (1998). Nke ikpeazụ bụ mmekorita mbụ ya na Adam Sandler; ha esonyelarị na 50 First Dates (2004) na Blended (2014). Ajụjụ: N'ọnọdụ dị aṅaa ka Drew Barrymore wepụtara akwụkwọ akụkọ ndụ ya mgbe ọ dị afọ iri na isii?
N'ịgbaso oge ọ bụ nwata nke ọgwụ ọjọọ na ịṅụbiga mmanya ókè mara nke ọma,