Nkọwa: Proteasomes bụ akụkụ nke usoro dị mkpa nke mkpụrụ ndụ na-achịkwa nchịkọta nke protein ụfọdụ ma mebie protein ndị a na-akpọ ubiquitin. A na-eji enzymes a na-akpọ ubiquitin ligases eme ka mmeghachi omume mkpado. Ozugbo a na-eji protein na-akpọ otu mkpụrụ ndụ ubiquitin, nke a bụ ihe mgbaàmà nye ligases ndị ọzọ iji jikọta mkpụrụ ndụ ubiquitin ndị ọzọ. Ihe na-esi na ya pụta bụ agbụ polyubiquitin nke na-ejikọta na proteasome, na-enye ya ohere imebi protein ahụ. Usoro mmebi ahụ na-enye peptides nke ihe dị ka asaa ruo asatọ amino acid ogologo, nke nwere ike mebie n'ime usoro amino acid dị mkpirikpi ma jiri ya na-emepụta protein ọhụrụ. A na-ahụ protein niile n'ime eukotes na archaea, na ụfọdụ nje bacteria. Ajụjụ: Kedu ụdị enzyme na-eme ka mmeghachi omume mkpado?
ubiquitin ligases