Mezue ahịrịokwu na-esonụ: E hiwere San Francisco na June 29, 1776, mgbe ndị si Spain bịa biri n'ebe ahụ guzobere ebe a na-akpọ Presidio nke San Francisco n'ọnụ ụzọ ámá Golden Gate nakwa ebe a na-akpọ Mission San Francisco de Asís, bụ́ nke dị kilomita ole na ole site n'ebe ahụ, ha abụọ kpọkwara aha Francis nke Assisi. Oké Ọkụ Ọlaedo nke California nke 1849 wetara uto ngwa ngwa, na-eme ka ọ bụrụ obodo kasị ukwuu n'Ebe Ọdịda Anyanwụ Coast n'oge ahụ. San Francisco ghọrọ obodo-county n'afọ 1856. Ọnọdụ San Francisco dị ka obodo kachasị ukwuu na West Coast ruru n'etiti 1870 na 1900, mgbe ihe dị ka 25% nke ndị bi na California bi n'obodo ahụ. Mgbe atọ n'ime ụzọ anọ nke obodo ahụ bibiri site na
Site na ala ọma jijiji na ọkụ nke 1906, e wughachiri San Francisco ngwa ngwa, na-akwado Panama-Pacific International Exposition afọ itoolu ka e mesịrị. Na Agha Worldwa nke Abụọ, San Francisco bụ ọdụ ụgbọ mmiri bụ isi maka ndị ọrụ ụgbọ mmiri na-aga Pacific Theater. Ọ ghọrọ ebe e guzobere òtù Mba Ndị Dị n'Otu na 1945. Mgbe agha ahụ gasịrị, njikọta nke ndị agha na-alọghachi, mbata na ọpụpụ dị ukwuu, omume nnwere onwe, yana ịrị elu nke "beatnik" na "hippie" countercultures, mgbanwe mmekọahụ, Ngagharị Udo na-eto site na mmegide megide itinye aka na United States na Agha Vietnam, na ihe ndị ọzọ dugara Summer of Love na mmegharị ndị nwoke nwere mmasị nwoke, na-eme ka San Francisco bụrụ ebe etiti nke mmegide na-emesapụ aka na United States. N'ihe gbasara ndọrọndọrọ ọchịchị, obodo ahụ na-eme ntuliaka nke ọma n'akụkụ ndị otu Democratic Party.