Boutros Boutros-Ghali a mụrụ na Cairo, Egypt, na 14 November 1922 n'ime ezinụlọ Coptic Christian. Nna ya Yusuf Butros Ghali bụ nwa Boutros Ghali Bey mgbe ahụ Pasha (nwekwara aha ya), onye bụ Prime Minister nke Egypt site na 1908 ruo mgbe e gburu ya na 1910. Nne ya Safela Mikhail Sharubim bụ nwa nwanyị nke Mikhail Sharubim (1861<unk>1920), onye ọrụ ọha na eze a ma ama na ọkọ akụkọ ihe mere eme.Boutros-Ghali gụsịrị akwụkwọ na Mahadum Cairo na 1946. Ọ natara PhD na iwu mba ụwa site na Mahadum Paris na diplọma na mmekọrịta mba ụwa site na Sciences Po na 1949. N'oge 1949<unk>1979, a họpụtara ya Onye isi oche nke Iwu Iwu na Mmekọrịta Mba Nile na Cairo. Ọ ghọrọ Onye isi oche nke Center for Political Studies na Strategic Studies na 1975 na Onye isi oche nke African Political Studies Society na 1980.
Yusuf Butros Ghali