Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Nkọwa: Ozizi banyere mkpụkọ ọbara adịwo kemgbe oge ochie. Ọkà mmụta ahụ ike bụ́ Johannes Müller (1801<unk>1858) kọwara fibrin, ihe mejupụtara ụbụrụ. N'ihi ya, Rudolf Virchow (1821<unk>1902) kpọrọ ihe na-ebute ya ụzọ, bụ fibrinogen, ma Prosper Sylvain Denis (1799<unk>1863) kewapụrụ ya. Alexander Schmidt tụrụ aro na ntụgharị site na fibrinogen gaa na fibrin bụ nsonaazụ nke usoro enzymatic, wee kpọọ enzyme hypothetical "thrombin" na onye bu ya ụzọ "prothrombin". N'afọ 1890, Arthus chọpụtara na calcium dị oké mkpa maka mkpụkọ ọbara. A chọpụtara platelet n'afọ 1865, Giulio Bizzozero kọwakwara ọrụ ha n'afọ 1882. Paul Morawitz kwadoro na ọ bụ n'afọ 1905 ka a chọpụtara na e nwere ihe na-eme ka ọbara na-agbasa n'ahụ́. N'oge a, a maara na a na-ewepụta thrombokinase/thromboplastin (factor III) site na anụ ahụ mebiri emebi, na-emeghachi omume na prothrombin (II), nke, ya na calcium (IV), na-etolite thrombin, nke na-agbanwe fibrinogen n'ime fibrin (I).  Ajụjụ: Olee mgbe Muller dịrị ndụ?
1801<unk>1858