Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Ịgafe: Ọtụtụ nnọchi nke nucleophilic na-adị mfe karị ọ bụghị site na pyridine nkịtị kama site na pyridine gbanwere na bromine, chlorine, fluorine, ma ọ bụ iberibe sulfonic acid nke na-aghọzi otu na-apụ apụ. Ya mere, fluorine bụ ihe kasị mma na-ahapụ otu maka nnọchi na organolithium ogige. Ndị nucleophilic mwakpo ogige nwere ike ịbụ alkoxides, thiolates, amines, na amonia (na elu nrụgide). N'ozuzu, ndị hydride ion bụ ogbenye na-ahapụ otu na-eme nanị na ole na ole heterocyclic mmeghachi omume. Ha na-agụnye mmeghachi omume Chichibabin, nke na-ewepụta pyridine derivatives aminated na 2-ọnọdụ. N'ebe a, a na-eji sodium amide eme ihe dị ka nucleophile na-enye 2-aminopyridine. Hydride ion a tọhapụrụ na mmeghachi omume a na-ejikọta ya na proton nke otu amino dịnụ, na-akpụ mkpụrụ ndụ hydrogen. N'otu aka ahụ na benzene, nnọchi nke nucleophilic na pyridine nwere ike ịkpata nhazi nke pyridyne dị ka heteroaryne. Maka ebumnuche a, enwere ike iwepu ihe ndị sitere na pyridine na ndị na-ahapụ ezi ihe site na iji ntọala siri ike dị ka sodium na potassium tert-butoxide. Mgbakwunye nke nucleophile na njikọ atọ nwere obere nhọrọ, na nsonaazụ ya bụ ngwakọta nke ihe abụọ nwere ike ịme.  Ajụjụ: Gịnị ka e ji sodium eme?
nucleophile na-enye 2-aminopyridine