Mezue ahịrịokwu na-esonụ: Mgbe Charles nke Ise na-eduzi Diet nke Worms, Francis nke Mbụ nke France zigara onye ọchịagha ya Robert de la Marck ka ọ wakpo Burgundian Low Countries ma kwado Henry nke Abụọ nke Navarre na mkpọsa iji nwetaghachi Navarre Iberia. Eze ukwu ahụ zaghachiri site n'ikwu na a napụrụ Francis Milan ma mepụta njikọ aka megide ndị France na Pope Leo X (8 Mee 1521), bụ onye nwere mmasị na ijikọta ókèala dị mkpa nke Parma na Piacenza, ha abụọ bụ akụkụ nke Milan nke ndị France. N'ụzọ dị otú a, Agha Afọ Anọ malitere. Ka ọ dịgodị, Cortés nọchibidoro (May 26) ma weghara (August 13)
Tenochtictlan, na-emezu mmeri nke Alaeze Ukwu Aztec. Ụgbọ mmiri bu nnukwu akụ nke eze ukwu Cuauhtémoc bụ nke onye France na-agba ụgbọ mmiri Jean Fleury jidere, mana ọla edo ruru 120,00 ducats ruru ụlọ akụ Imperial n'oge esemokwu Italy. Mercurino di Gattinara kọwara Renaissance Italy dị ka "isi ntọala nke alaeze ukwu" na ma Francis nke Mbụ na Charles nke Ise, bụ ndị a na-ewere dị ka ndị eze Europe kachasị ike n'oge ahụ, na-achọ ịdị elu na peninsula bara ọgaranya. Dị ka ọkọ akụkọ ihe mere eme nke oge Renaissance bụ́ Francesco Guicciardini kọwara: