Mezue ahịrịokwu na-esonụ: Mgbe oge 2011 gasịrị, ndị Giants bịanyere aka na López na nkwekọrịta afọ abụọ, $ 8.5 nde. Na July 6, 2012, López hapụrụ ụlọ mbụ ya ebe ọ bụ na ọ sonyeere ndị Giants na 2010 mgbe o kwere ka ụlọ obibi 457-ụkwụ gaa Pedro Álvarez na mmeri 6 na 5 na Pirates. Nke ahụ wetara ERA ya na 4.00, mana o dere 1.00 ERA n'egwuregwu 32 ikpeazụ ya. Mgbe mgba nke Santiago Casilla (onye dochiri Wilson merụrụ ahụ dị ka onye na-emechi ndị Giants), onye njikwa Giants bụ Bruce Bochy kwupụtara na August 7 na ndị Giants ga-aga na atụmatụ "bullpen site na kọmitii", na López, Sergio Romo, na Jeremy Affeldt na-atụgharị n'egwuregwu abụọ ikpeazụ nke egwuregwu dị nso, dabere na ndị na-eti ihe ha ga-eche ihu. Romo na López nwetara ọtụtụ ohere nchekwa; Affeldt nwere naanị otu nchekwa mgbe nke ahụ gasịrị. López natara ohere nchekwa isii mgbe Ọgọstụ 7 ma gbanwee nke ọ bụla n'ime ha. N'egwuregwu 70, López nwere ndekọ 3<unk>0, 2.50 ERA, na 28 strikeouts na 36 innings ka ọ na-agbanwe asaa n'ime ohere itoolu. O meriri 87.9% nke ndị na-agba ọsọ ketara eketa, akara nke atọ kachasị mma na NL. López pụtara ugboro ise na NLDS na
NLCS, na-enye ohere ọ bụla ka ndị Giants meriri usoro abụọ ahụ. Ọ gbabeghị na World Series mana ọ meriri mgbaaka World Series nke atọ ya ka ndị Giants kpochapụrụ ndị Detroit Tigers.