Cofactors nwere ike ịbụ ma inorganic (e.g., metal ions na ígwè-sulfur ụyọkọ) ma ọ bụ organic ogige (e.g., flavin na heme). Ndị a cofactors na-eje ozi ọtụtụ nzube; n'ihi na ihe atụ, metal ions nwere ike inyere kwụsie ike nucleophilic umu n'ime nọ n'ọrụ na saịtị. Organic cofactors nwere ike ịbụ ma coenzymes, nke na-tọhapụrụ site enzyme si nọ n'ọrụ na saịtị n'oge mmeghachi omume, ma ọ bụ prosthetic iche iche, nke na-ike agbụ enzyme. Organic prosthetic iche iche nwere ike ịbụ covalently (e.g., biotin na enzymes dị ka carboxylase). Ihe atụ nke enzyme na bụ a na-abụghị protein cofactor, nke a na-akpọ carbon hydroxide na ígwè-sulfur ụyọkọ) ma ọ bụ organic ogige (e.g., flavin na heme). Ndị a cofactors nwere ike ijere ọtụtụ nzube; n'ihi na ihe atụ, metal ions nwere ike inyere kwụsie ike nucleophi
organic ogige