Dee ihe na-aga n'ihu maka paragraf a - Na Ọktọba 22, 2018 nke "Raw", Reigns kwupụtara na a chọpụtara ya ọzọ na ọrịa leukemia mgbe afọ iri na otu gachara ma na ọ ga-ewe oge iji gwọọ ya. N'ihi nke a, ọ hapụrụ asọmpi Universal Championship, na-akwụsị ọchịchị ya nke were ụbọchị 64. Reigns nwetara nzaghachi dịgasị iche mgbe ọ banyere n'ọgbọ egwuregwu ahụ, mana a nabatara ya nke ọma yana abụ nke "Daalụ, Roman!" mgbe ekwuputara ọkwa ọrịa leukemia ya. Reigns mere nlọghachi ya na February 25, 2019 nke "Raw" iji kwupụta na ọrịa leukemia ya na-alaghachi, ebe ọ natara nnukwu obi ụtọ site n'aka ìgwè mmadụ ahụ. N'ime usoro nke "Raw" na-esote, Reigns ga-ejikọghachi ya na Ọta ahụ, na-eduga n'egwuregwu n'etiti Drew McIntyre, Bobby Lashley na Baron Corbin na Fastlane
, nke The Shield ga-emeri na egwuregwu mbụ nke Reigns kemgbe a chọpụtara ya na ọ na-arịa ọrịa leukemia. N'oge abụọ ahụ, a na-eji olu ụtọ anabata Reigns. Na WrestleMania 35, Reigns meriri Drew McIntyre na egwuregwu mbụ ya kemgbe Ọktọba 2018. Agbanyeghị, ọ ga-ezute mmeghachi omume dịgasị iche site n'aka igwe mmadụ ahụ, ebe onye edemede "Pro Wrestling Dot Net" bụ Jason Powell na-ekwu na ihe dịka "pasent 70 nke ndị na-akwado Reigns na-eme mkpọtụ mgbe naanị pasent 30 na-akwado ya tupu egwuregwu ahụ". Ọ ga-akọwakwa egwuregwu ahụ dị ka "ihe na-akụda mmụọ".