Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  Passage: Acetanilide bụ nke mbụ aniline derivative serendipitously hụrụ nwere analgesic nakwa dị ka antipyretic Njirimara, na ngwa ngwa ẹkenam n'ime ọgwụ omume n'okpuru aha nke Antifebrin site Cahn & Hepp na 1886. Ma nsonaazụ ya na-adịghị mma - nke kachasị njọ bụ cyanosis n'ihi methemoglobinemia - kpaliri ịchọ ihe ndị na-adịghị egbu egbu nke aniline. Harmon Northrop Morse emepụtaworị paracetamol na Mahadum Johns Hopkins site na mbelata nke p-nitrophenol na tin na glacial acetic acid na 1877, mana ọ bụ rue 1887 ka onye na-ahụ maka ọgwụ ọgwụ Joseph von Mering nwalere paracetamol na ụmụ mmadụ. N'afọ 1893, von Mering bipụtara akwụkwọ na-akọ banyere nsonaazụ ahụike nke paracetamol na phenacetin, ihe ọzọ sitere na aniline. Von Mering kwuru na, n'adịghị ka phenacetin, paracetamol nwere obere ọchịchọ imepụta methemoglobinemia. A tụfuru paracetamol ngwa ngwa n'ihi phenacetin. Ahịa nke phenacetin mere ka Bayer bụrụ ụlọ ọrụ na-emepụta ọgwụ na-eduga. N'ịbụ nke ọgwụ aspirin, nke Heinrich Dreser webatara na ọgwụ na 1899, mere ka ọ bụrụ ihe a ma ama ruo ọtụtụ iri afọ, ọkachasị na "mgwakọta isi ọwụwa" nke a na-akpọsa nke ọma, nke na-enwekarị phenacetin, ihe mgbochi aminopyrine nke aspirin, caffeine, na mgbe ụfọdụ barbiturate. Paracetamol bụ metabolite na-arụ ọrụ nke phenacetin na acetanilide, ha abụọ na-ewu ewu dị ka ndị na-egbu mgbu na ndị na-egbochi ọkụ n'onwe ha. Otú ọ dị, n'adịghị ka phenacetin, acetanilide na ngwakọta ha, a naghị ewere paracetamol dị ka carcinogenic na ọgwụgwọ ọgwụ. Nkwupụta nke Von Mering nọgidere na-enweghị mgbagha ruo ọkara narị afọ, ruo mgbe ìgwè abụọ nke ndị nchọpụta si United States nyochara metabolism nke acetanilide na paracetamol. N'afọ 1947, David Lester na Leon Greenberg hụrụ ihe akaebe siri ike na paracetamol bụ isi metabolite nke acetanilide n'ọbara mmadụ, na n'ọmụmụ ihe na-esote ha kọrọ na nnukwu ọgwụ paracetamol e nyere ụmụ oke albino emeghị ka methemoglobinemia. N'ime...  Ajụjụ: Olee mgbe e tinyere paracetamol n'akwụkwọ bụ́ British Pharmacopoeia?
Afọ 1963