Caffeine nwekwara ike na-etinye obi gị dum rectally, gosiri site suppositories nke ergotamine tartrate na caffeine (maka enyemaka nke migraine) na chlorobutanol na caffeine (n'ihi na ọgwụgwọ nke hyperemesis). Otú ọ dị, rectal absorption bụ obere oru oma karịa ọnụ: kacha ịta (Cmax) na ngụkọta etinye obi gị dum ego (AUC) na-ma banyere 30% (i.e., 1/3.5) nke ọnụ ego.Coffeine si ndu ọkara ndụ <unk> oge a chọrọ maka ahụ iji kpochapụ ọkara awa nke ọ bụla oge dịgasị n'etiti 1<unk>2 awa. Ọ na-ewepụ site mbụ n'usoro kinetics. Caffeine nwekwara ike na-etinye obi gị dum rectally, gosiri site suppositories nke ergotamine tartrate na caffeine (maka enyemaka nke migraine) na chlorobutanol na caffeine (maka ọgwụgwọ nke hyperemesis). Otú ọ dị, rectal absorption bụ obere oru oma karịa ọnụ: kacha ịta (Cmax) na ngụkọta absorbed ego (AUC) bụ ma banyere 30% (i
n'agbata awa 3<unk>7