Isi obodo na obodo kachasị ukwuu bụ Panama City, nke obodo ukwu ya bụ ebe ihe fọrọ nke nta ka ọ bụrụ ọkara nke mba ahụ nde mmadụ anọ. Panama bụ ebe ndị agbụrụ obodo biri tupu ndị Spanish colonialists bịarutere na narị afọ nke 16. Ọ kewapụrụ na Nueva Spain na 1821 ma sonye na Republic of Gran Colombia, njikọ nke Granada, Ecuador, na Venezuela. Mgbe Gran Colombia gbasasịrị na 1831, Panama na Granada mechara ghọọ Republic of Colombia. Mgbe United States kewapụrụ na Panama site na Colombia na 1999, na-enye ohere maka owuwu nke Canal Canal na ọdịda anyanwụ, Colombia na ndịda ọwụwa anyanwụ, Oké Osimiri Caribbean n'ebe ugwu, na Oke Osimiri Pacific na ndịda.
Afọ 1821