Meyers sonyeere Saturday Night Live cast na 2001. N'afọ 2005, a kwalitere ya ka ọ bụrụ onye na-ahụ maka ide ihe, na Jenụwarị 2006 ọ ghọrọ onye isi edemede, na-ekerịta ọrụ ya na Tina Fey na Andrew Steele. N'afọ 2004, ọ gbara ule iji soro Fey kwado Weekend Update, mana ọ furu efu Amy Poehler. Site na ọpụpụ Fey, Meyers ghọrọ onye isi edemede maka oge 2006-2007 ma were ọrụ nke Weekend Update na Amy Poehler. Mgbe Poehler hapụsịrị, Meyers gbara n'etiti 2008 na 2013. N'oge 2013-2014 oge, Cecily Strong sonyeere Meyers dị ka onye na-akwado ihe nkiri. N'oge mgbụsị akwụkwọ 2009, Meyers sooro abụọ nke Saturday Night Live Weekend Night with Tina Fey. Na SNL, Meyers na-eme ka ndị na-eme ihe nkiri dị ka John Carroll, Michael Carrot, David Anderson, Donald Kerry, Brian Peele, John McCarthy, John McCarthy, John McCarthy, John McCarthy, John McCarthy, John McCarthy, John McCarthy, John McCarthy, John
Afọ 2013