N'afọ 1885, Wilhelm Roux wepụrụ akụkụ nke medullary plate nke nwa ọkụkọ ma debe ya na ngwọta saline dị ọkụ ruo ọtụtụ ụbọchị, na-eguzobe ụkpụrụ nke ọdịbendị anụ ahụ. Ross Granville Harrison, na-arụ ọrụ na Johns Hopkins Medical School na mgbe ahụ na Mahadum Yale, bipụtara nsonaazụ nke nnwale ya site na 1907 ruo 1910, na-eguzobe usoro nke ọdịbendị anụ ahụ. Usoro ọdịbendị sel dị elu nke ukwuu na 1940s na 1950s iji kwado nyocha na virology. Na-eto eto na mkpụrụ ndụ mkpụrụ ndụ na-ekwe ka nkwadebe nke mkpụrụ ndụ dị ọcha maka mmepụta nke ọgwụ mgbochi.
afọ 1940 na 1950