Rịba ama amaokwu a dị n'okpuru ma zaa ajụjụ ahụ mgbe e mesịrị n'otu asụsụ ahụ dị ka amaokwu ahụ:  N'ụzọ: TRIPS e kwurịtara n'oge Uruguay Round nke General Agreement on Tariffs and Trade (GATT) na 1984-1994. Nsonye ya bụ njedebe nke usoro ihe omume nke United States ji arụsi ọrụ ike, nke ndị European Union, Japan na mba ndị ọzọ mepere emepe kwadoro. Mgbasa ozi nke agbamume akụ na ụba otu akụkụ n'okpuru Usoro Mmasị na ịmanye n'okpuru Nkebi nke 301 nke Iwu Azụmaahịa rụrụ ọrụ dị mkpa n'imeri ọnọdụ iwu na-asọ mpi nke mba ndị na-emepe emepe dịka Brazil kwadoro, kamakwa gụnyere Thailand, India na Caribbean Basin States. N'aka nke ya, atụmatụ United States nke ijikọta iwu azụmaahịa na ụkpụrụ nke ihe ọgụgụ isi nwere ike ịgbaso azụmaahịa nke ndị isi nchịkwa na Pfizer na mbido afọ 1980, bụ ndị kpọkọtara ụlọ ọrụ na United States ma mee ka ịbawanye ihe ùgwù nke ihe ọgụgụ isi bụrụ ihe kacha mkpa na iwu azụmaahịa na United States (Braithwaite na Drahos, 2000, Isi nke 7).  Ajụjụ: Olee mba ndị kwadoro TRIPS na nsonye?
United States, nke European Union, Japan na mba ndị ọzọ mepere emepe kwadoro