N'oge mmepe, anụmanụ extracellular matriks na-etolite a dịtụ mgbanwe kpuchie nke mkpụrụ ndụ nwere ike ịkwaga na-reorganized, na-eme ka e guzobere mgbagwoju owuwu kwere omume. Nke a nwere ike calcified, na-akpụ owuwu dị ka shells, ọkpụkpụ, na spicules. N'ụzọ dị iche, mkpụrụ ndụ nke ndị ọzọ multicellular organisms (tumadi algae, osisi, na fungi) na-ẹkenịmde ke ebe site cell mgbidi, na otú ịzụlite site na-aga n'ihu na-eto eto. Animal cell nanị nwere junctions akpọ tight junctions, ọdịiche junctions, na desmosomes.
collagen na glycoproteins na-agbanwe agbanwe