Mezue ahịrịokwu na-esonụ: Na Septemba 21, 2016, Santana kụrụ aka ya nke 150th na-arụ ọrụ, na-eme ya megide Kansas City Royals. N'oge oge a, Santana batara.259, 34 home runs, 87 RBI na.865 OPS. O mepụtara 30 home runs na 68 RBI mgbe ọ na-akụ aka ekpe. Santana gbara homerụ ugboro abụọ na 2016 American League Championship Series megide Toronto Blue Jays. O dekwara ikpeazụ nke Series site na ijide Troy Tulowitzki pop-elu na mpaghara ọjọọ, na-eziga ndị India na
Mkpokọta World Series. Chicago Cubs meriri Cleveland na World Series n'egwuregwu asaa. Ndị India jiri nhọrọ $12 nde ha maka afọ 2017.