Mezue ahịrịokwu na-esonụ: Assertio Therapeutics nwere Nucynta ER na Nucynta IR. Na Jenụwarị 15, 2015, Depomed kwupụtara nnweta nke Tapentadol ((Nucynta) franchise site na Janssen Pharmaceutica maka ego. Nkwekọrịta ahụ mechiri na Eprel 2, 2015, a maliteghachikwara ngwaahịa ndị ahụ na June 2015 mgbe nnukwu mgbasawanye ahịa ahịa. Mgbe
Hurricane Maria na 2017 ụlọ ọrụ ahụ chere nnukwu ụkọ ọgwụ ahụ n'ihi ebe nrụpụta nrụpụta na Puerto Rico. Na Jenụwarị 2018, mgbe ihe na-erughị afọ atọ, e rere ikike mmepụta nke Nucynta maka naanị $ 10 nde n'ihu na $ 135 nde na ikike maka afọ 4 mbụ. A na-emepụta Tapentadol ugbu a maka ahịa US na Canada site na Collegium Pharmaceutical.