N'agbanyeghi nchoputa a, mgbalị nyocha mba ụwa iji chọpụta nje ahụ, nke a na-akpọ na-abụghị A, na-abụghị B hepatitis (NANBH), dara na afọ iri sochirinụ. N'afọ 1987, Michael Houghton, Qui-Lim Choo, na George Kuo na Chiron Corporation, na-arụkọ ọrụ na Daniel W. Bradley na Centers for Disease Control and Prevention, jiri usoro mmepụta mkpụrụ ndụ ihe ọhụrụ iji chọpụta ihe a na-amaghị ama na nyocha nyocha. N'afọ 1970, Alter gosipụtara site na nyocha nke NANBH na nyocha nyocha. N'April 1989, Alter bipụtara nchoputa nke HCV. N'afọ 1998, Bradley tụbara ihe nchoputa ahụ site na nchọpụta nchoputa na nchọpụta nchoputa na nchoputa nchoputa na nchoputa nchoputa nchoputa nchoputa na nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nchoputa nch
Afọ 1987