TRIPS bụ mkparịta ụka nke Uruguay Round nke General Agreement on Tariffs and Trade (GATT) na 1984-1994. Ntinye ya bụ njedebe nke mmemme nke nrụgide siri ike nke United States, nke European Union, Japan na mba ndị ọzọ mepere emepe kwadoro. Mgbasa ozi nke agbamume akụ na ụba otu akụkụ n'okpuru Usoro Mmasị na ịmanye iwu n'okpuru Nkebi nke 301 nke Iwu Azụmaahịa rụrụ ọrụ dị mkpa n'imeri ọnọdụ iwu na-asọ mpi nke mba ndị na-emepe emepe dịka Brazil kwadoro, kamakwa gụnyere Thailand, India na Caribbean Basin States. N'aka nke ya, atụmatụ United States nke ijikọta iwu azụmaahịa na ụkpụrụ ọgụgụ isi nke ọgụgụ isi na Pfizer na mmalite afọ 1980, bụ ndị kpọkọtara ụlọ ọrụ na United States ma mee ka ihe ùgwù ọgụgụ isi nke ọgụgụ isi bụrụ ihe kacha mkpa na United States.
United States, nke European Union, Japan na mba ndị ọzọ mepere emepe kwadoro