Mezue ahịrịokwu na-esonụ: Na Rio de Janeiro, Adrian nwetara ihe nrite anọ. O nwetara ihe nrite mbụ ya dị ka arịlịka maka 4 × 100 mita freestyle relay n'akụkụ Caeleb Dressel, Michael Phelps, na Ryan Held. Ndị America, na Dressel na Held dị ka ndị asọmpi Olimpik nke mbụ, kwụsịrị na oge 3:09.92, nke France na Australia sochiri. Oge ikpeazụ Adrian gbara bụ sekọnd 46.97, nke kachasị ọsọ n'ọhịa. N'asọmpi nke mbụ ya,
Na 100 mita freestyle, Adrian enweghị ike ịgbachitere aha Olimpik ya, na-emetụ nke atọ n'azụ Kyle Chalmers na Pieter Timmers na 47.85 sekọnd. Adrian nwetakwara ọla nchara ọzọ n'ọsọ mita 50 n'ụdị ịgba ọsọ n'efu, na-agba ọsọ n'ihe dị ka sekọnd 21.49. Onye America ọzọ, Anthony Ervin, meriri na 21.40 sekọnd ma onye na-agbachitere Olympic Florent Manadou wee bụrụ onye nke abụọ. O ji ọlaedo ọzọ merie asọmpi Olimpik ya n'ọsọ 4x100-meter medley relay n'ụbọchị ikpeazụ nke asọmpi ahụ, na-egwu mmiri n'akụkụ Ryan Murphy, Cody Miller, na Michael Phelps. O ji 46.74 kewaa oge ya wee nweta ọla edo n'oge 3:27.95, nke bụ ihe ndekọ ọhụrụ n'egwuregwu Olimpik.