Dee ihe na-aga n'ihu maka paragraf a - Site na 1493, mgbe ndị Spain biri n'àgwàetiti ahụ, na gọọmentị site na 5 August 1498, Santo Domingo ghọrọ obodo Europe kacha ochie na America. Bartholomew Columbus guzobere obodo ahụ ma kpọọ ya La Nueva Isabela, n'ihi obodo mbụ dị n'ebe ugwu nke a kpọrọ aha Eze Nwanyị Spain bụ́ Isabella nke Mbụ. N'afọ 1495, a gụgharịrị ya "Santo Domingo", iji sọpụrụ Saint Dominic. A bịara mara Santo Domingo dị ka "Ọnụ Ụzọ Ámá nke Ebe Ndị Caribbean" na isi obodo Hispaniola site n'oge ahụ gaa n'ihu. Njem ndị dugara ná nnupụisi nke Ponce de León nke Puerto Rico, nnupụisi nke Diego Velázquez de Cuéllar nke Cuba, mmeri nke Hernando Cortes nke Mexico
, na Vasco Núñez de Balboa hụrụ Oké Osimiri Pacific niile si na Santo Domingo.