N'afọ 1966, Tony lụrụ onye na-elekọta ụlọ nke ezinụlọ Joan Gustafson. Ha mụrụ ụmụ abụọ, Jennifer na Mario. Madonna were iwe na nna ya maka ịlụ di ọzọ, wee malite inupụrụ ya isi, nke mere ka mmekọrịta ha sie ike ruo ọtụtụ afọ mgbe nke ahụ gasịrị. Ọ gara St. Frederick na St. Andrew's Catholic Elementary Schools, na West Middle School. A maara Madonna maka akara ugo mmụta ya dị elu, wee nweta aha ọjọọ maka omume ya na-adịghị mma. Ọ ga-eme cartwheels na handstands na paseji n'etiti klaasị, na-adabere n'ikpere ya site na ogwe osisi na-egbuke egbuke n'oge ezumike, ma na-adọpụ uwe mwụda ya n'oge klas ka ụmụ nwoke wee hụ uwe ime ya. Nna Madonna tinyere ya na obere piano, ma o mechara mee ka ya kwenye ka ọ ghara ikwe ka ya nwee obere ballet. Onye nkuzi ballet ya, Christopher Flynn, kwụsịrị, wee malite inupụrụ ya, nke mere ka mmekọrịta ha sie ike ruo ọtụtụ afọ mgbe nke ahụ gasịrị. Ọ gara ụlọ akwụkwọ St. Frederick na St. Andrew's Catholic Element
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