 Additional protection with progestogens is therefore important in patients with an intact uterus who receive estrogen therapy.Dydrogesterone counters the proliferative effect of estrogens on the endometrium and ensures the transition to a secretory pattern and cyclical shedding of the endometrium in serial menopausal hormone therapy regimes.Dydrogesterone effectively protects against the ontogenesis of endometrial hyperplasia.