 The 5α-reduced metabolite of ethisterone, 5α-dihydroethisterone, has been found to show reduced androgenic activity relative to ethisterone.Interestingly, ethisterone showed antiandrogenic activity when co-administered with dihydrotestosterone (DHT) in animals, whereas 5α-dihydroethisterone did not.Testosterone is aromatized into estradiol, and norethisterone, the 19-nortestosterone analogue of ethisterone, has similarly been shown to be aromatized into ethinylestradiol.