 The drug is described as a relatively weak androgen with partial activity and is rarely used for the purpose of androgen replacement therapy, but is still widely used in medicine.Mesterolone is used in androgen replacement therapy at a dosage of 50 to 100 mg 2 to 3 times per day.Mesterolone has been used for physique- and performance-enhancing purposes by competitive athletes, bodybuilders, and powerlifters.