 It received a Dutch patent for lynestrenol in 1957, and lynestrenol subsequently became a component of "Lyndiol", the first Dutch contraceptive pill, in 1962.Around this time, pre- and post-marketing clinical trials of lynestrenol were conducted, and in 1965, a study consisting of 200 Dutch women was published.Lynestrenol was approved, in the United Kingdom, in combination with mestranol in 1963 and in combination with ethinylestradiol in 1969.