 In order to attain a gaseous sample for GC-MS, the products of hydrolysis are extracted, dissolved in methanol and derivatised to form volatile trimethylsilyl (TMS) esters by adding "N"-methyl-"N"-trimethylsilyl-trifluoroacetamide (MSTFA) and trimethylsilylimidazole (TMSImi).Fluoxymesterone was first described in 1956 and was introduced for medical use in the United States in 1957.Over time the use of fluoxymesterone has become increasingly controversial and limited.