 In the ensuing years, other patients with similar levels of hippocampal damage and amnesia (caused by accident or disease) have also been studied, and thousands of experiments have studied the physiology of activity-driven changes in synaptic connections in the hippocampus.There is now universal agreement that the hippocampi play some sort of important role in memory; however, the precise nature of this role remains widely debated.The third important theory of hippocampal function relates the hippocampus to space.