 The word "bitch" during the twenties meant "malicious or consciously attempting to harm", "difficult, annoying, or interfering", and "sexually brazen or overly vulgar".In modern usage, the slang term bitch has different meanings depending largely on social context and may vary from very offensive to endearing, and as with many slang terms, its meaning and nuances can vary depending on the region in which it is used.The term "bitch" can refer to a person or thing that is very difficult, as in "Life's a bitch" or "He sure got the bitch end of that deal".