 When the estimated daily intake (EDI) is compared to the intake at which adverse effects are seen (known as the "highest no-effects limit", or HNEL at 1500 mg/kg BW/day, a large margin of safety exists.The bulk of sucralose ingested is not absorbed by the gastrointestinal tract (gut) and is directly excreted in the feces, while 11–27% of it is absorbed.The amount absorbed from the gut is largely removed from the blood stream by the kidneys and eliminated in the urine, with 20–30% of the absorbed sucralose being metabolized.