 Different thalamic nuclei, (from the anterior and midline groups), the medial septal nucleus, the supramammillary nucleus of the hypothalamus, and the raphe nuclei and locus coeruleus of the brainstem all send axons to the EC, so that it serves as the interface between the neocortex and the other connections, and the hippocampus.The EC is located in the parahippocampal gyrus, a cortical region adjacent to the hippocampus.This gyrus conceals the hippocampus.