 It has also been suggested that hippocampal dysfunction might account for the disturbances in long-term memory frequently observed.MRI studies have found a smaller brain volume and larger ventricles in people with schizophrenia–however researchers do not know if the shrinkage is from the schizophrenia or from the medication.The hippocampus and thalamus have been shown to be reduced in volume; and the volume of the globus pallidus is increased.