 The family contains about 13,500 species in 611 genera, which makes it the fourth-largest angiosperm family.Rubiaceae has a cosmopolitan distribution; however, the largest species diversity is concentrated in the (sub)tropics.Economically important species include "Coffea", the source of coffee, "Cinchona", the source of the antimalarial alkaloid quinine, some dye plants ("e.g.