 Ferrara grew into a cultural center renowned especially for music; Josquin des Prez worked for Duke Ercole, Jacob Obrecht came to Ferrara twice, and Antoine Brumel served as principal musician from 1505.Ercole's daughter Beatrice (1475–1497) married Ludovico Sforza, Duke of Milan; another daughter, Isabella (1474–1539), married Francesco Gonzaga, Marquess of Mantua.Ercole I's successor was his son Alfonso I (1476–1534), third husband of Lucrezia Borgia, daughter of Pope Alexander VI, sister to Cesare Borgia.