 The arcuate nucleus and the periventricular nucleus of the hypothalamus have dopamine neurons that form an important projection—the "tuberoinfundibular pathway" which goes to the pituitary gland, where it influences the secretion of the hormone prolactin.Dopamine is the primary neuroendocrine inhibitor of the secretion of prolactin from the anterior pituitary gland.Dopamine produced by neurons in the arcuate nucleus is secreted into the hypophyseal portal system of the median eminence, which supplies the pituitary gland.