 Gene silencing at this location depends on components of the RNAi pathway.Double-stranded RNA is believed to result in silencing of the region through a series of steps.In the fission yeast "Schizosaccharomyces pombe", two RNAi complexes, the RITS complex and the RNA-directed RNA polymerase complex (RDRC), are part of an RNAi machinery involved in the initiation, propagation and maintenance of heterochromatin assembly.