 In 1883 he succeeded Friedreich at the University of Heidelberg, where he worked until his retirement in 1907.Psychiatrist Emil Kraepelin (1856-1926) and neurologists Ernst Julius Remak (1849-1911), Max Nonne (1861-1959) and Paul Julius Möbius (1853–1907)  were among his better known students and assistants.Up until his death in 1921, he served as honorary president of the "Gesellschaft Deutscher Nervenärzte" (Society of German Neurologists).