 Tuitopou moved to Munster for the 2010–11 season, replacing Jean de Villiers as Munster's inside centre.Shortly after gaining his first team place he was banned for three weeks after a spear tackle on Paul Hodgson during Munster's Heineken Cup pool game against London Irish.In his short time at Munster, he became a fan favourite, being awarded the nickname "Hacksaw Sam" by the Munster supporters.