 During her term as senator from 1968 to 1972, Antonino worked for the passage of laws including Republic Act 6124 (Providing for the Fixing of the Maximum Selling Prices of Essential Articles or Commodities and Creating the Price Control Council); RA 6235 (Prohibiting Explosives and Flammables, Corrosive or Poisonous Substances or Material in Passenger Aircraft and Regulating the Loading thereof in Cargo Aircraft); and RA 6395 which consolidated and revised the Charter of the National Power Corporation.She also helped enact laws that benefited women and children, farmers through increased production of rice and corn, and people from the government and education sectors.She was treasurer of the Antonino Construction Enterprises (1946–1953); secretary-treasurer, then manager, Western Mindanao Lumber Co.; general manager, G. E. Antonio, Inc., treasurer, Polytechnic Colleges of the Philippines; director, Philippine Commercial and Industrial Bank and Luzon Cement Corporation.