 It is located in the Brewers Hill Historic District.The National Brewing Company site was first used in beer production in the 1850s, when brewer John Baier rented land at O'Donnell and Conklin Streets in Lager Beer Hill into which beer storage cellars were dug.After Baier's death in 1866, his widow Anna Maria Baier continued to operate his brewery, which was located on Canton Avenue.