 Through the 2010s, "25 or 6 to 4" continued to be a staple in Chicago's live concert set list and in Peter Cetera's solo concert set list.In 2016, the group's former drummer Danny Seraphine reunited on stage with Chicago to perform "25 or 6 to 4" and two other songs at their induction ceremony for the Rock and Roll Hall of Fame.According to composer Robert Lamm, the song is about trying to write a song in the middle of the night.