 In 1666, Isaac Newton fled London from the plague.Isolated, he applied rigorous experimentation and mathematics, including development of calculus, and reduced both terrestrial motion and celestial motion—that is, both physics and astronomy—to one theory stating Newton's laws of motion, several corollary principles, and law of universal gravitation, set in a framework of postulated absolute space and absolute time.Newton's unification of celestial and terrestrial phenomena overthrew vestiges of Aristotelian physics, and disconnected physics from chemistry, which each then followed its own course.