 Neuronal and glial cells migrate through the weakened barrier resulting in the accumulation of neural tissue in the subarachnoid space.This abnormal migration, known as cortical dysplasia, is theorized to be one of the primary causes for FCMD.It has been demonstrated that the clinical signs of experimental autoimmune encephalomyelitis (EAE) are only evident after the penetration of inflammatory cells across the glia limitans and upon entrance into the CNS parenchyma.