 Within the Portuguese territory of Brazil, and even beyond its original borders, the enslavement of Native Americans was carried out by the Bandeirantes.Among many other European slave markets, Genoa, and Venice were some well-known markets, their importance and demand growing after the great plague of the 14th century which decimated much of the European workforce.The maritime town of Lagos, Portugal, was the first slave market created in Portugal for the sale of imported African slaves, the "Mercado de Escravos", which opened in 1444.