 Ample research on the cycad hypothesis found a component of the seeds, cycasin, was a potent toxin; it was discovered in the 1950s.As toxic as it was, it would not be the cause of the symptoms of lytico-bodig.Not only that, after nearly two decades of NIH-funded researches, animal models failed to reproduce the chronic Lytico-Bodig and the hypothesis was rejected for the first time.