 Jackson played in NFL Europa for the Rhein Fire in 2006, leading the team with 731 rushing yards.Jackson was invited to training camp with the Buffalo Bills in 2006 by Bills general manager Marv Levy, a Coe College alumnus himself.He made his first career start against the Washington Redskins in 2007, rushing for 82 yards while catching four passes for 69 yards in a Bills victory.