 The 5' and 3' ends of the genome segments match up, creating a panhandle structure.This base pairing occurs in all hantavirus species, with the panhandle structure and sequence being unique to each particular species, of course with some similarities and overlap between species, including an eight nucleotide consensus sequence.There are four major viral proteins, the two surface glycoproteins (Gn and Gc), the nucleocapsid protein (N), and the viral polymerase (L).