 On 16 October 2017, Takam was made a late replacement to fight Anthony Joshua on 28 October at the Principality Stadium, Cardiff, after Joshua's opponent Kubrat Pulev pulled out of their fight with a shoulder injury.Takam gave a brave performance and took Joshua 10 rounds before the referee stepped in and waved the fight off after Joshua landed a flurry of punches.On 15 June 2018, it was confirmed that Takam would face Dereck Chisora on 28 July at The O2 Arena, London, England, on the undercard of Dillian Whyte vs Joseph Parker.