 Lord Abercorn died in his forties, unmarried, about 1680, in Padua, Veneto, Italy, on his way to Rome,

With his death the senior line of the Abercorns failed.The title passed to the nearest cadet branch which was that of the barons Hamilton of Strabane, who descended from his uncle Claud.The representative of this line, Claud's grandson, Claud Hamilton, 5th Baron Hamilton of Strabane, therefore became the 4th Earl of Abercorn.