 TAL effector nucleases (TALENs) are particularly interesting because TAL effectors appear to be very simple to engineer

and TALENs can be used to target endogenous loci in human cells.But to date no one has reported the isolation of clonal cell lines or transgenic organisms using such reagents.One type of ZFN, known as SB-728-T, has been tested for potential application in the treatment of HIV.