 February 3, 1829 von Pfeilitzer-Franck was made official for important missions ("чиновник для особых поручений") by the Governor-General of Novorossiysk and Bessarabia.This was the time of a plague epidemic in the South of Russia, and Baron was charged with the mission of preventing its further spread and complete extinction.In 1830 he was awarded with an Order of St. Stanislaus of 1st degree for success in fighting the epidemic, and in 1830 - 1831 he was the president of the preventive committee in Kherson and Odessa, fighting the cholera epidemic.