 The most widely known dependovirus is adeno-associated virus (AAV) which was originally discovered as a contaminant in a sample of simian adenovirus.Though AAV is considered to be dependent on adenovirus, it is able to replicate in the presence of herpesvirus as well as certain cytotoxic events such as UV irradiation or some carcinogens During the course of a natural dependovirus infection, if the helper virus is not present, the dependovirus is often capable of integrating into the host genome and going into a latent phase of its life cycle—effectively waiting for the next helper virus infection.For gene therapy uses, the vector is stripped of its ability to integrate.