 There is an example of an insertional mutagenesis event caused by a retrotransposon in the human genome where it causes Fukuyama-type muscular dystrophy.Insertional inactivation is a technique used in recombinant DNA engineering where a plasmid (such as pBR322) is used to disable expression of a gene.The inactivation of a gene by inserting a fragment of DNA into the middle of its coding sequence.