 To be active orally (like in ayahuasca) it must be combined with a monoamine oxidase inhibitor such as Syrian Rue ("Peganum harmala"), which grows throughout the Mediterranean.Alternatively, J. Nigro Sansonese (1994), using the mythography supplied by Mylonas, hypothesizes that the Mysteries of Eleusis were a series of practical initiations into trance involving proprioception of the human nervous system induced by breath control (similar to samyama in yoga).Sansonese speculates that the "kisté", a box holding sacred objects opened by the hierophant, is actually an esoteric reference to the initiate's skull, within which is seen a sacred light and are heard sacred sounds, but only "after" instruction in trance practice.