 These span the four technology domains of Advanced Manufacturing and Engineering (AME), Health and Biomedical Sciences (HBMS), Urban Solutions and Sustainability (USS), and Services and Digital Economy (SDE) set out under the nation's five-year R&D plan (RIE2020).The agency's research institutes are located mostly in Biopolis and Fusionopolis.The total strength of the A*STAR community, including scientists and researchers, technical and non-technical staff, and industry development and commercialization staff was 5,400.