 The few remaining "refugee missions" were destroyed by South Carolina's invasion of Spanish Florida in 1702 during Queen Anne's War.By 1733, the Mocama and Guale chiefdoms had become too depopulated and helpless to resist James Oglethorpe's founding of the English colony of Georgia.In their colonial period, the Spanish established a missionary province at the Guale chiefdom just north of Mocama, on the Georgia coast between the Altamaha River and the Savannah River.