 It has also been suggested that leptin secretion also plays a role in the release of GH from periventricular nucleus and that this hormone interacts with both somatostatin and growth hormone-releasing hormone (GHRH) in the GH release pathway.This is further supported by the presence of leptin receptors in neurons of the periventricular nucleus.GH may also be able to provide regulatory feedback on the periventricular nucleus by increasing cytokine signaling to the hypothalamus which inhibits the GH release pathway.