 Due to severe population losses from infectious disease and warfare with northern Indian tribes and the English from South Carolina, the Mocama polity disintegrated in the 17th century.After that, the Spanish and later settlers used the term "Mocama" to refer to the land where the chiefdoms had been.Between 1675 and 1680, the Westo tribe, backed by the English colonies of South Carolina and Virginia, along with attacks by English-supported pirates, destroyed the Spanish mission system in Mocama.