 Leading nutrition companies such as Nestlé (Nestle Research Centre) and Danone (Nutricia Research) have either established new facilities or expanded existing ones in Biopolis, and are working closely with A*STAR to conduct R&D to develop healthier and safer products.Singapore's first publicly funded drug candidate, ETC-159, which was discovered and developed through a collaboration with Duke-NUS Graduate Medical School, advanced into Phase 1 clinical trials in July 2015.This drug targets a number of cancers, including colorectal, ovarian and pancreatic cancers, which contribute to a significant proportion of Singapore's cancer burden.