 The catalytic triad has been identified as Ser122, His269, and Asp239.Monoacylglycerol lipase catalyzes a chemical reaction that uses water molecules to break the glycerol monoesters of long-chain fatty acids.It functions together with hormone-sensitive lipase (LIPE) to hydrolyze intracellular triglyceride stores in adipocytes and other cells to fatty acids and glycerol.