 PA 49 begins at an intersection with PA 44 north of the borough of Coudersport in Eulalia Township, Potter County, heading east on a two-lane undivided road.The route heads through forested areas of hills with some farm fields and homes to the north of the Allegheny River, turning northeast and crossing into Hebron Township.The road curves east and enters Allegany Township, curving back to the northeast and turning east again at Colesburg.