 Set in New York City after a virus, which was originally created to cure cancer, has wiped out most of mankind, leaving Neville as the last human in New York, other than nocturnal mutants.Neville is immune to the virus and he works to develop a cure while defending himself against the hostile mutants.It is the third feature-film adaptation of Richard Matheson's 1954 novel "I Am Legend", following 1964's "The Last Man on Earth" and 1971's "The Omega Man".