 The highway's interchange with US 50 opened in the early 1950s when the U.S. Highway was relocated between Bowie and Annapolis.MD 424 temporarily extended south to MD 2 in the early to mid-1950s and north to the Little Patuxent River in the 1970s and early 1980s.MD 424 begins at an intersection with MD 214 (Central Avenue) within the Davidsonville Historic District.