 PA 25 intersects PA 225 in Berrysburg, PA 125 in Hegins, and Interstate 81 (I-81) in Frailey Township.PA 25 was designated in 1928 to run from US 209 in Millersburg east to PA 443 in Pine Grove, running east to Hegins before heading southeast to Tremont and south to Pine Grove.The road between Hegins and Newtown was designated as PA 125.