 The eastern terminus is at PA 287 in Lawrenceville less than south of the New York-Pennsylvania border.PA 49 serves as North Street, North Main Street, and Northern Potter Road in Ulysses, as Cowanesque Street in Lawrenceville, and as both East and West Main Street for Harrison Valley, Westfield, Knoxville, and Elkland.It is concurrent with PA 249 for between Cowanesque and Knoxville.