 The northern terminus is at the Bradford Bypass, carrying U.S. Route 219 (US 219) and PA 346, in Bradford roughly two miles south of the New York-Pennsylvania border.PA 46 was first signed in 1927, extending from U.S. Route 6 in Smethport north to US 219 in Bradford.The route was extended southward to Emporium in 1928 when the eastern segment of Pennsylvania Route 47, which ran along present-day PA 46 from PA 120 in Emporium to US 6 in Smethport, was decommissioned after only one year of service.