 In the 12th century it was known as "Vicus pecudis", and was connected to the commune of Tortona, sending relief troops to that city during the siege laid by Frederick Barbarossa in 1155.In 1347 Tortona was annexed by the Visconti of Milan who, in 1412, gave Volpedo as a fief to the condottiero Piero Cameri.The latter ceded the town to the Cathedral of Milan.