 SR 180 splits from US 13 by turning east and US 13 continues north-northeast through woods alongside the inactive railroad tracks.The road intersects SR 1420, which leads west to the Accomack County Airport, before it passes to the east of Eastern Shore Community College, which is accessed by SR 389.The route runs through more woods before it reaches the town of Melfa, where it becomes a five-lane road with a center left-turn lane and passes a mix of homes and businesses, crossing SR 626.